<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="http://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CB90</accession>
    <name>A0A398CB90_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Creatininase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_28815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the creatininase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00416">
        <property type="protein sequence ID" value="RIE00416"/>
        <property type="gene ID" value="D3H35_28815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="293" mass="32782" checksum="FFE033A9C8A3AA5D" modified="2018-12-05" version="1">MKPNIGDKTLWAELLPFEFNRRLAENPVVYLPLGICEPHGQVSAFGLDTFKAEWLCTEAAKRMGGIVAPSLGYHIHETGYHARWLQDEIGEEKAPMTAMPPDVFLLFFLYQLRAFVNSGFRTIVVVSGHSGGNQRDLRLAADIFMKYVPVQVWVCSDPELVEDLFEGDHAGKYEISQLMYIKPPFIDMALQRLEKAPGSGGRLALGLDASEANEALGKEIMEACLARLCDEISRLQAACLDQAAKKITPAQMEVIRGEVLASVSKWVTTKPWPEQQAVGKESQWKPFEYYSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBW7</accession>
    <name>A0A398CBW7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00273">
        <property type="protein sequence ID" value="RIE00273"/>
        <property type="gene ID" value="D3H35_29575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039650">
        <property type="entry name" value="HdrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498">
        <property type="entry name" value="PTHR43498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="463" mass="50048" checksum="429AF6C34E2FC435" modified="2018-12-05" version="1">MSEHIDYKVSIPVIAQVDVLVIGGGPAGIGAAIAAARAGATTAIVERYGFLGGNATAGLVGPFMTSYSDDGETQLVKGVFDELVVRMEKIGGAMHPENVAAGSSFSGFFIKGHDHVTPFDPEAVKLVAAEMMVESGVQMFLHSFFMDTIVEDGCVKGGIILNKSGPQAIHAKVTIDCSADGDVAYKAGSAMEVGRKSDGMTQPMTMFFRVAGVDDEKIERYVEEHPEEQHMLFHTLIEEKRKTGEWQVKKNHLGVYRTTQPGVYRVNTSRIQGLDGTNVADLTNAEIEGRKQVFELIAFFRKYFPGFENATLIDTAAQIGIRETRRLVGEYVLTADDIVTGRDFDDVIALYGYPIDIHSPNEVTTEFDAAYHTANIYQLPYRILVPAETDGLLLAGRCVSATHEALGAIRVMPCAFALGQAAGAGAALASRNGVQPRHVNTAQLQKLLHEQGVVLPRDLKTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CC42</accession>
    <name>A0A398CC42_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkaline shock response membrane anchor protein AmaP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">amaP</name>
        <name evidence="3" type="ORF">D3H35_26385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00726">
        <property type="protein sequence ID" value="RIE00726"/>
        <property type="gene ID" value="D3H35_26385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="187" mass="20133" checksum="A535D3BB217F61C9" modified="2018-12-05" version="1">MIRMLDRLLLFLYSIAIGAASVIAIAAACGAFQTSFLKNAVSDFTGESRSIQGTVIGVGIVLFLVSLRFFIVSVRRTGASAPTINQRTEHGDIRISVETVENLALKAASRTKGVKDLRARVRIAESGLEITIRAFIEGEGSIPAMSEDMQRTVSQQIEEATGIPVAEVSVFIANVTQSPTTFKSRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCQ3</accession>
    <name>A0A398CCQ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_28150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000054">
        <property type="protein sequence ID" value="RIE00490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00490">
        <property type="protein sequence ID" value="RIE00490"/>
        <property type="gene ID" value="D3H35_28150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="64" mass="7192" checksum="7B0FD2592A146262" modified="2018-12-05" version="1">MWQLVRYLSFIPLRLTHTEFIDKLKTGDEKFTGEIGMKAANLLSTLGKAGISKKASAAWIIRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCZ8</accession>
    <name>A0A398CCZ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_28015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00583">
        <property type="protein sequence ID" value="RIE00583"/>
        <property type="gene ID" value="D3H35_28015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="46"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE00583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="436" mass="46719" checksum="32A78C115A16419F" modified="2018-12-05" version="1">MATAKSRPNLRIGSQEKDSSRSSRPTANPKTSNKGASTGRGSRIWEYIALASVPVVLVLGNSMLVPILPTLKRQFGISQFQTSLVISLFSVAAGLIIPVAGYLSDRYSRKKVMIPALILYGGAGILAGFGAVWESYPVLMGARILQGVGAAGTAPIAMALVGDMYKDGEESQALGLIEAANGSGKVISPILGALLALVIWYAAFFAFPVFCALSVVAVIFLIKEPKRKEEPKPLREYVKAIGTLFRKNGRWLLASFFGGSLALFILFGVLFYLSDILEQKPYSIDGVRKGFVLAIPLFGMVVTAYVTGSVIRKNGVLIRLLMNVGLALMVVSLALAIWLNANLYVFIGLLTVSSVGTGLLLPCLNTMITGAVEKAERGMITSLYSSLRFLGVAFGPPLFGWMMGISHRTVFISVSALSFVALCLVFFMVKPGKQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDH6</accession>
    <name>A0A398CDH6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="14">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="14">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">metG</name>
        <name evidence="19" type="ORF">D3H35_26535</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 14">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="14"/>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00753">
        <property type="protein sequence ID" value="RIE00753"/>
        <property type="gene ID" value="D3H35_26535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02800">
        <property type="entry name" value="tRNA_bind_EcMetRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01228">
        <property type="entry name" value="Met_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004495">
        <property type="entry name" value="Met-tRNA-synth_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="PTHR43326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00399">
        <property type="entry name" value="metG_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14 16" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="18">
        <location>
            <begin position="569"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="530"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="14">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="14">
        <location>
            <begin position="300"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RIE00753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="669" mass="74773" checksum="50ED4A7B2180FB69" modified="2018-12-05" version="1">MSESKKSFYLTTPIYYPSAKLHIGHAYSTVAGDAMARYKRLRGYDVRYLTGTDEHGQKIERKALEAGKTPQQFVDDIVVGIKDLWKKLDISNDDFIRTTEARHKQSVEKIFTRLVQQDDIYKGSYEGWYCTSDESFFLERQLVDGKCPDCGASVEWVQEESYFFRMSKYADRLLAYYEEHPDFIQPESRKTEMINNFIKPGLEDLAVSRTTFDWGIPVPGDPKHVIYVWIDALSNYITALGYASDDDSLFRQYWPADVHLMSKEIVRFHTIYWPIMLMALELPLPKKVFAHGWLLMKDGKMSKSKGNVVDPVTLIDRYGLDALRYYLMREVPFGADGTFTPDSFVERINYDLANDLGNLLNRTVAMIDKYFGGEVPAIVPGSTAFDDALAETAAQAVDKVETALENMEFSVALTAIWTLVSRTNKYIDETQPWALARSEANINTLGSVMGHLAESLRIVSVLIRPFLTQTPARIWAQLGIAEGEATSWESIGAFGGFPARTKVSKGDPIFPRLDMAEEVAWIAQAMTGGTAASEPQAKAQEPSEKAAAPEGASGQAEEIERKDEINIDDFAKVELRVAQVVACEPVPKADKLLKLQLDLGFEQRQVVSGIAKHYKPEELVGRKVICVTNLKPVKLRGETSQGMILAASEGDSLTLATVPDSMPNGAIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDJ4</accession>
    <name>A0A398CDJ4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_22985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01256">
        <property type="protein sequence ID" value="RIE01256"/>
        <property type="gene ID" value="D3H35_22985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="10"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="315"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="349"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="566" mass="62285" checksum="4688890D69D61C78" modified="2018-12-05" version="1">MEGSLRMARMECRNLTFTYAQADRPALQGISLTVARGEFVVLSGPSGSGKSTLLRLLKREVSPGGTLHGSILLEGRPLQDWDDREAAAAVGLVMQHPDNQLVVDRVEHELAFGMENFGLSRGEMKRRMAEMAGFFGLEPLLARRTDELSGGQKQTVNLAAVLMMQPSVLLLDEPLAQLDPLAARDLLGMIKRLNEEWGITVILSEHRIDDLLPLADRIVRLEHGEIAFQGPPREFASEAWARGGDEWAASLPAVTSWALNRGENREGLPPLLPPLTVKEARAWLSSDSLSERGITAGGAQEEEAKRTSRDEPILLGASGLYFSYDPRTPAVIRGLEWDVRLGDWISLFGGNGSGKSTLLQLMAGLRKPQRGEVKLSGERLKKIPETARYARIGYLAQNPLLHYAHETLEEDLRHAALRAGLPEPTEEARGLARRFGIEQLMDRHPHDLSGGERQLGALAMTLASRPELLLLDEPTKGLDPMAKRRLAGHLAEAHRLGTAIVMATHDVEFAAAYATRCSLLFRGEIVADDRPEAFFRGNLFYATALHRLFASTRPVANSVGEEPIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDL6</accession>
    <name>A0A398CDL6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01276">
        <property type="protein sequence ID" value="RIE01276"/>
        <property type="gene ID" value="D3H35_23090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="91" mass="10428" checksum="4D9E7CE74E44F2C3" modified="2018-12-05" version="1">MKKFIVSLLGTLVVFIAIVWTSKTTMTGEIVKIKEINNEKVTIENLNGRVAAIEAPKTILNLIAVDKQYYFEYKKYRWRGPKLTNIQPIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDQ6</accession>
    <name>A0A398CDQ6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pyrimidine-nucleoside phosphorylase</fullName>
            <ecNumber evidence="8">2.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D3H35_27910</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2'-deoxyuridine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:22824"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + thymine</text>
            <dbReference type="Rhea" id="RHEA:16037"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:17821"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>phosphate + uridine = alpha-D-ribose 1-phosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:24388"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.2" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00565">
        <property type="protein sequence ID" value="RIE00565"/>
        <property type="gene ID" value="D3H35_27910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047847">
        <property type="term" value="F:deoxyuridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016154">
        <property type="term" value="F:pyrimidine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009032">
        <property type="term" value="F:thymidine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006213">
        <property type="term" value="P:pyrimidine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013102">
        <property type="entry name" value="PYNP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018090">
        <property type="entry name" value="Pyrmidine_PPas_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017872">
        <property type="entry name" value="Pyrmidine_PPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="PTHR10515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07831">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000478">
        <property type="entry name" value="TP_PyNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00941">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54680">
        <property type="entry name" value="SSF54680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02644">
        <property type="entry name" value="Y_phosphoryl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00647">
        <property type="entry name" value="THYMID_PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PYNP_C" evidence="12">
        <location>
            <begin position="345"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00011889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00014680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE00565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="433" mass="45645" checksum="00DB345D5649C93B" modified="2018-12-05" version="1">MRTVDLIAKKRDGEPLTREEIEFLIQGYTAGTIPDYQMSALAMAIYFNGMTSQERADLTLAMVNSGEVIDLSAIAGIKVDKHSTGGVGDTTTLVVAPLVASVGVPVAKMSGRGLGHTGGTVDKLESIPGFHVEIENDSFHELVNRNGIAIIGQSANLTPADKKLYALRDVTATVESIPLIASSIMSKKIASGADAIVLDVKTGDGAFMKQMSETKDLAACMVDIGNRVGRRTIAVISDMNQPLGFAIGNALEVKEAIDTLKGEGPEDLYELSLTLGSHMVVLAGKASELVEARAMLEHSVKSGRALEKFKQFLAAQGGDATVVDEPHRLSAAPYLIDVPARKEGFVSAIAAERIGLAAMKLGAGRATKEASIDLAVGIVLRKKIGDAVAEGESVATIHSSTEQAAEVLDLIYESIAIQPGQVERPPLIYEVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDV7</accession>
    <name>A0A398CDV7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactonase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01366">
        <property type="protein sequence ID" value="RIE01366"/>
        <property type="gene ID" value="D3H35_23640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="366" mass="39775" checksum="1D12D3AF77C8EDCF" modified="2018-12-05" version="1">MTTPENSQASAFEIWIGAYGAKDEVTLTRLQLFSDTAELVKAAEYAGIEDASFLRMNRSGTRLYAVSETLETDGEEGGQLASFPIEPDTLKLGPVQFHRTYGAHPCHLSLAPEEDWLAVSNYNGASVTLFMITPDSRPSPAVIRLCHTGSGPNEQRQEAPHPHAAVFSPDGNYMFVPDLGLDRVMVYARGPEANEWSGHEAISMAPGDGPRHFAFHPSGRAAFVVNELSCTVTRFTYDEKEGALGRQESITTLPSSFKGDNTCAEIVVSPDGRFVYASNRGHDSIAIFRIDDATGRIEAAGHVSTRGSNPRNFALTPDGCWLIAANQDSDNVVLYRIEPNSGLPIFAGTEIAVRKPVCVLIREART</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE79</accession>
    <name>A0A398CE79_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphocarrier protein HPr</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_21405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01013">
        <property type="protein sequence ID" value="RIE01013"/>
        <property type="gene ID" value="D3H35_21405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001020">
        <property type="entry name" value="PTS_HPr_His_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002114">
        <property type="entry name" value="PTS_HPr_Ser_P_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00369">
        <property type="entry name" value="PTS_HPR_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00589">
        <property type="entry name" value="PTS_HPR_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPr" evidence="6">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="89" mass="9546" checksum="073CF20697B69826" modified="2018-12-05" version="1">MTKQPVVVRLKTGLHARPAALFVQEANKFSSDVFVEKDEKKVNAKSIMGIMSLAISSGTEVAISAEGSDAEQAVTALVQLVSKEELENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEE7</accession>
    <name>A0A398CEE7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_24660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01546">
        <property type="protein sequence ID" value="RIE01546"/>
        <property type="gene ID" value="D3H35_24660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="281" mass="30924" checksum="26A859271A3194A4" modified="2018-12-05" version="1">MHHLRRAAYRYRERRTDSRIFPKRRRILFARNFARKERGRMIAQLSYLTGEELRKLLRGGKLKVLLLLAFLIGVFLVFIGDRIGLDDNLPSTALELLLAIVFPLFMASLGSDLMVGEFKDRTIKHALKLPVSRESLFMGKMLAGWTAGALIVLSVFVPTLIGSLVLQGVPALSELGANLAELGAAILFCGLLVVLANCVALWTGSGGVGLTVSVVLWMAMGVVGLLEPQSSRFLVTEFTDWVRPLLYAGDAGASISTLLFIIAYYIIGTILGLLSFQRKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF18</accession>
    <name>A0A398CF18_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01323">
        <property type="protein sequence ID" value="RIE01323"/>
        <property type="gene ID" value="D3H35_23375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025275">
        <property type="entry name" value="DUF4015"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13200">
        <property type="entry name" value="DUF4015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4015" evidence="1">
        <location>
            <begin position="75"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="397" mass="44206" checksum="92996B542D8197A4" modified="2018-12-05" version="1">MNGHRLAPRCSFFKSIFVLNLAMVLMFMSGCGNEQEQRLPLPKSMETRENLRVLKLSSGKPPAPVFQPLGQPVRAVYVSSFAALSGRMDKLIELVNETELNALVIDVNSGARLTGLSRPAGSQSYPMAQTRSVSSMSRLVKKLKENHIYLIARIVTFKDAALADSNPRWAIRSKEGKVWKDRGGNAWIDPFREEAWAYPIALAEQASSMGFDEVQFDYVRFPENGSKVDREVQYANKHGWSKSEAISRFLRAATDKVHAKGAKISADVFGLVTSTADMGIGQRWGAISSEVDVISPMIYPSHYSNGMWGIRHPDLTPGLVVSRALADATRENAKLLSAGKHAARVRPWLQGFTAGWVRPHQTYGKDQIQEQIRAARKAGYSSYMLWNSASRYPIFHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFD7</accession>
    <name>A0A398CFD7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_24005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01433">
        <property type="protein sequence ID" value="RIE01433"/>
        <property type="gene ID" value="D3H35_24005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005085">
        <property type="entry name" value="CBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007541">
        <property type="entry name" value="Uncharacterised_BSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321">
        <property type="entry name" value="PTHR33321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04450">
        <property type="entry name" value="BSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03423">
        <property type="entry name" value="CBM_25"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01066">
        <property type="entry name" value="CBM_25"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="180"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="560"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="744"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="923" mass="100598" checksum="B1BD9CD050824C8A" modified="2018-12-05" version="1">MEWRETGEKGALPRGRASIARWIVVVMAVILLTGTWGGALPKAEASGTPTAYPLNRATGGTVTASGEYAIAGEVKENAFDNNLYAKWLVNSSTAWIEYHFPGAAAYAINSYTLTSANDYSERDPKNWTLKGSNDGTNWTLLDTRTNENFSRRFDTRTYEFTNATSYKHYRFDFENHSGGALQVAEIKLFDGSTRTYSAIQPTVTVSGENTPNEGKGNLTDDNSRTKWLTFSATGWVRLDYGQAITLDGYALISGNDAPERDPKSWTLKGSNDGSTWTTIDSQSNVTFLYRHQRNHFLVLNNTTAYRYYQFDFQSNGASILQLSDIDLSYQEDMWHEVNPIVEFQVQDTIGYGYLFEQAIPHPVENIQAIIREVCAQLYDNPGEMLRGPRKVKVTVVDSGVAGTSGTGSEALVAFGAGYMRDYTNNSGKPLREELFAVLYHELTHVYQYDDQRYGQIGYMIEGMASAMTYKAGIYDRYSYPTGGTWQDGYGNTANFFRWVDEHRHPGFLRELNASLNPFDGVDWTPSAIEQITGVDVTTLWNEYQSRLPELRDYDIVPPTVPAGLAYTSKTSTSVSLSWGASTDNFNVAGYTIYRDGAKVGTTTSTSYTATGLSSSTAYSFTVKAFDTEGLFSAASSALSVTTDSGNTVTVYYKQGYSTPYIHYRPAGGSWTTVPGVAMPASEVSGYNKITINIGTATQLEACFNNGSGTWDSNNGNNYFFPVGTSTYNAGTIVSGAPDSQAPTAPTNLTSTAKTDTTVSLSWTASTDNVGVTGYDIYQGTTKIGTSTTTSYTATGLSGNTAYSFTVKARDAAGNVSAASSALSVTTNPSVGNTVTIYYKRGFSTPYIHYRQANNAWTTTPGVAMSTSEVSGYNKITINIGSLTQLEACFNDGNGNWDSNYGSNYFFSTGTWTYNAGSITAGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFM5</accession>
    <name>A0A398CFM5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-siderophore ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00702">
        <property type="protein sequence ID" value="RIE00702"/>
        <property type="gene ID" value="D3H35_26245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="18"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="241" mass="26213" checksum="7318524B9BB72071" modified="2018-12-05" version="1">MTIAHALGTATIKETPKRIVYLYQGALDMSAALGVKPVGAVESTDQKPWFAYLGDMNGVENLGDEGQPNVEAIVALKPDLIVATKVRHEKIYAQLEAIAPTIVTEDLADWKTSLPIVAKALGKVSEANALLEDWNGRVAEFKKKMGDKLASTTVSLIRVQRDGSVKVYLKGFPGLMMQELGLAPPKSQQVEFSGSGLDITSKEHIPQFDADYIFDLTTVLPGQESIPDLYKEWTSHLSGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG36</accession>
    <name>A0A398CG36_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pilus assembly protein TadB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_25350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00902">
        <property type="protein sequence ID" value="RIE00902"/>
        <property type="gene ID" value="D3H35_25350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="73"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="246" mass="27853" checksum="9AA3F0A3DAE8F54D" modified="2018-12-05" version="1">MTDYRSYTLSRRERAFGVALGCFACFTAIWLLYQNFWIATIGSSAGLFYPRLLKKRLCRNRQERLRLHFKEALQGLSSLLAAGRSVESAFALLERDLAYLLGEGTSDLLKELRTIANRMHNGEPLEQPLRDLAVRSGVEDIANFAEVFVVCKRSGGDMVEVIRRTSQLIGEKLEVELEMTVLMAQKRFESKFLMAMPFAFVGLLGFFAPEYMAALRQGMGWVLLTGGLALLGFCCWWIARIMAIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG41</accession>
    <name>A0A398CG41_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplI</name>
        <name evidence="11" type="ORF">D3H35_24250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01470">
        <property type="protein sequence ID" value="RIE01470"/>
        <property type="gene ID" value="D3H35_24250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L9_C" evidence="10">
        <location>
            <begin position="63"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE01470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="147" mass="16055" checksum="ED06EF88A07A401C" modified="2018-12-05" version="1">MKVIFLQDVKGQGKRGEVKDLSEGYVRNFLLPKGLVQVATEGAQKSIDQINAAAQKRKDKEKEDAKALAAKLSELTVVIKAKAGEGGRLFGAITSKQIAEALEKLKIVVDKRKIEMDEPIRTLGVTKVPVKLYPDVKGTLNVQVAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG63</accession>
    <name>A0A398CG63_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01490">
        <property type="protein sequence ID" value="RIE01490"/>
        <property type="gene ID" value="D3H35_24360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="82" mass="8744" checksum="B7CE9AF47082659B" modified="2018-12-05" version="1">MTGVWLAIAAFGLLLAIGFRSIWRNGRKREALLYAAVVVWCAFIAVPGIAGHKPLMSPVAASIAIFSPIGKLMYQLLGSSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGB9</accession>
    <name>A0A398CGB9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lasso peptide biosynthesis B2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01773">
        <property type="protein sequence ID" value="RIE01773"/>
        <property type="gene ID" value="D3H35_13300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032708">
        <property type="entry name" value="McjB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13471">
        <property type="entry name" value="Transglut_core3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglut_core3" evidence="1">
        <location>
            <begin position="50"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="171" mass="19569" checksum="D75B34A40D1B33D4" modified="2018-12-05" version="1">MRARSGGIRGADGKSGNYCCRAMRRVWRSLHHKQVALEALCLMATARFCMLFIPFRRLAPHLGTIHTDTLMDPRSQGNPQLIEIKRTVHRIGKKTWWKSECFVRASAIAWMLRRRGRGYTIYLGVAKDEAQQLIAHAWIRSGAQWMSGAGQRDRYTVVATFSAQPRRKDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGK9</accession>
    <name>A0A398CGK9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_25085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01620">
        <property type="protein sequence ID" value="RIE01620"/>
        <property type="gene ID" value="D3H35_25085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026876">
        <property type="entry name" value="Fn3_assoc_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13287">
        <property type="entry name" value="Fn3_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017380551" description="SLH domain-containing protein" evidence="2">
        <location>
            <begin position="51"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="119"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="804" mass="83258" checksum="88A4514DFD5475A1" modified="2018-12-05" version="1">MLSPDVVLCRKMMNFAYEGTNPMKRKLSGLALAVLVGFNAAACYPNTAAAKTSADFTDLKDLDAATKAKFDALISAGVFDGVSDTKFGLKDEMNRAQFAKVAALITGIEVNKDLKTSSFSDVQADDAANGYALPYIEALKTAGITAGYGEGTYNPAGKVTKEQLAAFLVRVLGKDADAKAMTGDDTTVSNWAQGYVAAALELKLLDNGADGKFGGKANATRDLLLTGAYEAKQQYVPPGKVSVAGATQVGVRKISVSFNKAVDSSQITLSVKKGGSAAGGANVAWAADYRSATLTFNEDLKEEQIEIAVTGFDPSVWERTSATVTATPEKIVKIEFTSAGDTIARARAVAIPFKATNQFGETPQDSTKFKFSVSSGVSATIASNTMAVEVNTLSKETGDRISVSVTEQVSGVQVTRVYTVGAASEEPPVIISTPSAVAKPTADVASGAVAIGTSVTLSAASGATIYYTTDGSTPSASGGTEYNEPIPVTHAMTIKAIAVKSGMTNSGVLTLSYTILSQTETPTANVASGAVAIGTSVTLSAASGATIYYTTDGSTPSASGGTEYNEPIPVTHAMTIKAIAVKSGMTNSNVLTLSYTILLQAAMPTADVASGEIGYGTYVHLSAASGATIRYTLNGSTPTDEIMDMNSFTYNEGSPIYVVNNMTLKAVAFQAGVAASEVLTLNYTINPNAQPIAVTGLTYIGESEEKSLLKVTFSKAVASTSAAESANYEVWQGMGISMMPVSVISATRGGVGHENEVTLEVDSLTGLGPGTPIRVVVSSVQSADDSSDTIQNGNHTSEFYWSYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGP0</accession>
    <name>A0A398CGP0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01122">
        <property type="protein sequence ID" value="RIE01122"/>
        <property type="gene ID" value="D3H35_22150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="207" mass="23893" checksum="6177665068443042" modified="2018-12-05" version="1">MTISQTSGLSQERRERAFQEAVSFAKFVEEAQVNQRTLTANYEAYAPEERQLDFLNDRQEPVDVLVLAHDWCGDVVANLPLFGKIADRTDKLRLHILNRDPDNQDIADLYKHADGRSHIPTYVFFDQSGQELGVFIERPAEITALLGQWIESFWNEHPELEGRGKPISELGESEKKELLRYLKLRRTEVIGQEQEAILREIQSIVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGZ2</accession>
    <name>A0A398CGZ2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyl-accepting transducer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_29495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00178">
        <property type="protein sequence ID" value="RIE00178"/>
        <property type="gene ID" value="D3H35_29495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="2">
        <location>
            <begin position="80"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="498" mass="55078" checksum="1CB30203A8E1A7A9" modified="2018-12-05" version="1">MKVTHMFKITSRSHTEIAAQLQRFADGDFTAVASPVAAKRKNDSLLFTLRRSSNSLRTLLRLVFRSSRELGDRLDSVTQRSEIISGQAATVTNTIQEVTLGVQEAAENVQRMSEEIAVIHGNLQELQLHSDDISASSSTYRSTVEQGLEAMGRLTGTLETMVGDSEEMTAEMREFREAFVMIANMSKLIDDIASQTQLLALNANIEAARAGDHGTGFAVVAQEVSKLALQTRESAVRITEQMTAATRRSGRLEEAVERMKASVLESSSAMEETTERFKGFAKFIADTDGQLQRMNGNLRAVTDSTSSLSEAVMSTSAMVEQMAAGTEEALASVDVQQHNILSMNESVRQAVSTGMSLRSAVSQFKLPAENGMTPLSSAIESWMEGALGVRAIMLSMIECRAPEDIRAWNERKLAMEQQLEQRFEELAVHCADSRDSRCLAELREAWESFHRTKDRNAGYMLNGEYEKARQGLTQQGRQLFKAALDHAIQWMEDEPIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH41</accession>
    <name>A0A398CH41_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02526">
        <property type="protein sequence ID" value="RIE02526"/>
        <property type="gene ID" value="D3H35_17705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="284" mass="31494" checksum="F5AE487DE5489AE2" modified="2018-12-05" version="1">MSRKGSPIISIRHKPIYLNPEGGKRLKRLILAPTAALLASVMIMTACTETKKRSRTEPAEVHFQSLFPETANDDPYVKVLLNAVAHFNELNSDIKVVVDYMPAGTTMVTEQDIFKLLRSDKAPDIIGFPVSQVQVAGQENLLFDLRRVSDKKALDIPERVLDLASIDGKLLALPYAAYPSIVMYNKETFDAANLTYPQGEWTWEQFQDIAEKINKDGGSLLPYDIEALDLLAGSAGQGLLSPDGETAVGYLDSPEAIKALRWMNETYRKGSDDASKSRKTEWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH91</accession>
    <name>A0A398CH91_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PIN/TRAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_30020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ycf81 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00268">
        <property type="protein sequence ID" value="RIE00268"/>
        <property type="gene ID" value="D3H35_30020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="3">
        <location>
            <begin position="292"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="363" mass="39018" checksum="E5C636C688EA0135" modified="2018-12-05" version="1">MVMKRVIQAIGLLLGSLMGQEWSSWRGTGGAAWMDPLLGGSQGTGGTYGAIVGAFIGLLIATTAAGPLSRSLQNGVDRLAAFPMADLMFGLAGLTSGLALSALMYPFLSDVPRFGSMVAACTALTFGYAGLRIGIQRKDELGEWLRSRRAAEQAKEEGSWFEEHKILDTSVIIDGRIADICKTGFIEGTLVIPEFVLEELQHIADSSDLLKRNRGRRGLDILNKIQKELDVKVLICEDAVEEAVEVDSKLVKLAKAMRGKVVTNDFNLNKVCELQGVSVLNINDLANAVKPVVLPGEEIVVQVIKDGKEHGQGVAYLDDGTMIVVEGGRDFIGTTMEVLVTSVLQTSAGRMIFAKPKLLEKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH98</accession>
    <name>A0A398CH98_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II secretion system protein GspE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_23560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01352">
        <property type="protein sequence ID" value="RIE01352"/>
        <property type="gene ID" value="D3H35_23560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="556" mass="62305" checksum="456617B2F24CBFEE" modified="2018-12-05" version="1">MLPRKKLGDLLIEAGLLTEEQLQSALEEQGKSKLRLGDVLISKNYVTEQQVIDVLVHQLGIPYVQVHELPIDSQVISLVPQKLAERQKVLPVSREGNKLVVAMNNPLDYFAIDELRMTTGMQIVPVITSKEELERSISRFYGFQESVDQIAKRLEQNEIVDANSMLQDDIYSPVIKTVNQIIEQAVQVGASDIHFDPQEDGLRIRYRVDGVLRSEKKLPIHMQKVISARVKIMAQLDIAERRLPHDGRLELTIDRRKIDIRISTLPTMFGEKIVMRILDSKNKNNKLSNLGFAESNLSRFEEGIHSPYGMVVIAGPTGSGKTTTLYSAIQQLNSDDVNILTIEDPVEYQLQGINQVQVNPGPGLSFAKGLRSMLRQDPDIVMVGEMRDLETAEISVRAAMTGHLVLSTLHANNSVNAITRLLDMGVEPFLLSSSLNCVVAQRLVRCVCKGCAEKYKPSLEERKWFEMQGIKVEEMQRGTGCLQCSQTGYKGRVAIHEVLLLDDTLRSMIINRRSDADYREHAVKQGLLSLLHDGLQKAAAGLTTLQEVLRVTSRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHQ8</accession>
    <name>A0A398CHQ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00659">
        <property type="protein sequence ID" value="RIE00659"/>
        <property type="gene ID" value="D3H35_27230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="406" mass="43689" checksum="EA5D3AF27110C7CC" modified="2018-12-05" version="1">MPQAVKVRKADEESTRSRSHSREESEQEEQSEEAEQSPDKAATMERLKAEGAVRVFPGMDAGPKPEAPEATEAPTAPQAATAPSAEVEASEGESEGVGTGISQDFHDRVKRETDAANNPKWYNLPQHISNARHGEWDLSKSRERSGNRKQDVNLEEDVRTNQIEKRILPGKFDIKQKAKNAVNDVIQNPGQTAAGMIPLVGKGIQQKMAEKYDVKERDLMRGIAATSTDESIQSSAASQAKALGTKITTGRVKAGIGTVTGIAGNIIPGAGQVAGAVGTAAGMIGDIATSGAQTQVKKARAREEARRAMGKKEFAGYENIDEFIGLEQQRHALVDAGKGKAGAAAPAIDGQDQVKRLTAHARGETEHHKHYKRRAKEVEQERAAAAKPKEEGTGLMSRMKKFFGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHT6</accession>
    <name>A0A398CHT6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01895">
        <property type="protein sequence ID" value="RIE01895"/>
        <property type="gene ID" value="D3H35_14030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="237" mass="27094" checksum="D01F7CD6390C5DFF" modified="2018-12-05" version="1">MLKWFKRLFSTPSGSGSYDRTRKFAYGYRIPAGLGVRQELTGHASGLLTGLEAALTEPYLRQVKSRVIAAHPEISNAQYGWMELEMKRFFALTAIVRNVPMYSDDADLVWHEMLMFTREYQQFCDSFAGFYIHHQPNVAPAPKARALNWTTEPHSSSSMLRYSTCRQRISDCSALSINGKFSWSSWMSCSRQTIAGCAPRFVFAIRRILTFKPCRTASWRRFAAVRLKPIPSITRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHU3</accession>
    <name>A0A398CHU3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02363">
        <property type="protein sequence ID" value="RIE02363"/>
        <property type="gene ID" value="D3H35_16750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="315" mass="35053" checksum="5064DC73E0EBD83E" modified="2018-12-05" version="1">MRSAMQMTKKTTLRDVAKEAGVSVATASYVLNNVTNQTIPTETKKRVYEAAEKLQYVQNLTARALSLGRTNLLGVLLVGDESDLISKHISYGKFIDRLERLSLEQNYHLIVARIDPRQPNFDIILERKLDGAFVIDAAESSFYAVSEKFKFGSPVVLVDSAIADPLFRHVTPDFGQLFGIISQLCGDQPYVIAHEKYHNQTLTDSLYAASGVGSDRVYAIARDSGSLTAFAREHRNKPLVVFNEFLALHLMKDCDPSNMVVVCTSDCPDFLPRSVRRIVPMADKAKTTFELMHALLGEPFSASDRMLPFAAMDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIH5</accession>
    <name>A0A398CIH5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01862">
        <property type="protein sequence ID" value="RIE01862"/>
        <property type="gene ID" value="D3H35_13835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="40"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="229" mass="25698" checksum="F4E7E4496A365969" modified="2018-12-05" version="1">MPDHAKIYLEEAEKYARLIASQPPLDGVIEEIRPFEGLDIVDIGAGTGRLSAVLAPRAKSLVALDASQAMLNETARQLSEAKLSNWRTEVADHRRLPLEDGCADLVVAGWSVCYLASADAPDWEDNLRIVMSELKRIVRSKGTIILFETMGTGVETPAPPDFLLPYYAQLANLYGFAHRWIRTDYLFESTKEAEEMTRFFFGDELGDRVAREELLRVPECGGVWWLHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIJ5</accession>
    <name>A0A398CIJ5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Histidinol-phosphatase</fullName>
            <shortName evidence="7">HolPase</shortName>
            <ecNumber evidence="4 7">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hisJ</name>
        <name evidence="9" type="ORF">D3H35_21445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="4 7"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01019">
        <property type="protein sequence ID" value="RIE01019"/>
        <property type="gene ID" value="D3H35_21445"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="PTHR21039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="8">
        <location>
            <begin position="4"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="268" mass="30579" checksum="2A7B0862AD67509D" modified="2018-12-05" version="1">MRIDYHTHNVRCGHAVGTLPEYIESAIEKGMEEIGLSDHMPLLHVDPATYYPEMAMPMDELPRYVEECLTLKERYKNRIKVKVGLEGDFIEGYEEPISRIIEAYPWDYVIGSVHFLGTWDITDFRQVHNWEGKRAIEVYERYYDAVRKAAATGLYDYIGHIDAIKRFGFRPEEDVSTLEDAALETVAKHGLAIELNAAGIHTAAKEMYPSFRMLERAKAYHIPVTFGSDAHHPGKVGQKGAEAQTMLKNVGYSHLATFEGRKRTLIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIU4</accession>
    <name>A0A398CIU4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Ribonuclease H</fullName>
            <shortName evidence="5">RNase H</shortName>
            <ecNumber evidence="4 5">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rnhA</name>
        <name evidence="7" type="ORF">D3H35_16415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4 5"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02305">
        <property type="protein sequence ID" value="RIE02305"/>
        <property type="gene ID" value="D3H35_16415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09278">
        <property type="entry name" value="RNase_HI_prokaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00042">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022892">
        <property type="entry name" value="RNaseHI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="148" mass="16814" checksum="D150D46DE304FF45" modified="2018-12-05" version="1">MKEVTIYTDGACSGNPGPGGWGAVLMFGEHRKDLSGAEKMTTNNRMELLAAIEALSILKEPCKVKLHSDSAYLVNCFQQGWMKGWIRNGWRNSKGQPVENRDLWERLAELMKNHQVEYVKVKGHSDNELNNWCDQMAREAVARLRNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJH4</accession>
    <name>A0A398CJH4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_17600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02505">
        <property type="protein sequence ID" value="RIE02505"/>
        <property type="gene ID" value="D3H35_17600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032812">
        <property type="entry name" value="SbsA_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13205">
        <property type="entry name" value="Big_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017314011" description="SLH domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="76"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="688" mass="73799" checksum="2E00861AD7FA06C6" modified="2018-12-05" version="1">MKKFALAILALSLLLGAAIPAAWAAELTTEQKFEALKKQGILVGMGDGNPRLYELMTREQFAQVLHRLLELPNATGKPTYSDVLKGRWSFDEIEAVTEAGLMVGTAPRKFSPAATVTVEQLASVLVRAYGSPAGAATVSGKVSNWARMSVGAALNNGFIASRSDYTAGATRGVLVDAVYAYFVKTQQSPLNVRSVEPITNQAVKINLLQRAETVDASLFLLQDSQGTSIPVYQAMLGGDGMYVILTTGTQAEARKHYVYVGGKAWEFTSTRSDTAKPLITGLTKSANRTYVLTFSEQLDQASAANPSNYSLSNGLKLKTLQLSADKMSVVFTTTTQSEGVRYYLTVKNVKDAAGNAMDTRSDLSFNGTNDDTKPKVSSVQINPSATLSVRFSEKVDPQLAIQTGRYKIDKGLSVLKAVIDGEGRTVTLTTSAQKDATVYTLTVSGIPDAAGNVMDTQTNLLFGGIANPVLPIRLQSISAIDENTVEIVFADRALTDSDIAKLNFVVLQDNGANISMSGWSRYVQRKAGSDRTVTVQIRTSGEANPRLFSPGHYYLGRVTGVESLLTDEGKNDMKFGGTVTSNEAPFVTKAVALSRSSVKVFFSEPVKNVNETSFAIQEQEGPAVAIDYDELNNTGAVVTEVILRLKDSLSPGKVYAMTFKQGVTDAAGWNGLKLKNGGSDFNVLFTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJM1</accession>
    <name>A0A398CJM1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_17805</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02545">
        <property type="protein sequence ID" value="RIE02545"/>
        <property type="gene ID" value="D3H35_17805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07473">
        <property type="entry name" value="Peptidases_S8_Subtilisin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045351">
        <property type="entry name" value="DUF6531"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034204">
        <property type="entry name" value="PfSUB1-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20148">
        <property type="entry name" value="DUF6531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017289492" evidence="6">
        <location>
            <begin position="32"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="171"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6531" evidence="8">
        <location>
            <begin position="494"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="705" mass="73665" checksum="5BCF1FDF462EB282" modified="2018-12-05" version="1">MEDSMKAPLKALTKLALSALIASTAAYDWSAATAVAQAAAPAAPAPRHKTELIVKYKNGGNSQTAQTNVKKKLKLNKMNVKKKSKRARLEVLQIGENDSLDQTIAEMNNDPNVEYAQPNYKLYVSALPQDEHFDEQWGIANSGQKIGSQVGIPGVDIDAVRAWDVTEGSPSVLVGVLDTGMDVSHPDLAANVFTNSAEIPDNGIDDDGNGYVDDVHGYDFAGGDASVFDSASSDKHGTHVAGIIAAQADAAGIRGVAPQTKLLPLKFISDGAGYTSDAIEAIEYAQQMGASIVNMSFGGPDNNPALQDAMTASGMLFVAAAGNHGASVDAQPIYPASLRLPNLLSVTAIDNKGELASFSGYGSTVDIAAPGVGIVSTVPGGGYAALSGTSMAAPFVTGTAALLKSLYPDLSSAELAARLKATVKPVAGLASKVATQGIVSAAGSLAGTYTEPAVASDPAASPKPGAASGDSAVVALAEEVSPELLEQIHYGEEGVNVATGNYGKSVTDLSVTAPGFVVNISRTYNSKDDRTTSSLGRGWTFGFEGSLKDDTKNSKLKVAKLPSGGAQVFVKNGNAYTANDSRSTLEKQADGSHLLTTKDQYRYGFNPSGYLAWMEDRSGNRLTIETDAVGKARKITDTVGRIFQLTYNASGYLQTVKDPIGQTITYEYDASNRLKQVKDQTGQVTAIYDYDSSHYLNVIKDGQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK59</accession>
    <name>A0A398CK59_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4430 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_22995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01258">
        <property type="protein sequence ID" value="RIE01258"/>
        <property type="gene ID" value="D3H35_22995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027954">
        <property type="entry name" value="DUF4430"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14478">
        <property type="entry name" value="DUF4430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017415094" evidence="2">
        <location>
            <begin position="29"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4430" evidence="3">
        <location>
            <begin position="162"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="251" mass="25852" checksum="C5B5F37A37D22083" modified="2018-12-05" version="1">MKKWWRKRLWAGLFAAILLTASVGCAESATNGTPPSSPASVAPSSPLSQPETKDATDTEASAGPADASASASSSPQAADASSKASAAPSEEPSNGSKPSDEAASSSKPSPNAGDKKPRGAKPVESPSPSPSAETANAATLTIVGNKEWGIVLAPEEVSLKKGDTAASVLKRAGKAHRLVVDARGSGSLTYIEGIDGLYEFDDGPLSGWKYRVNGVVMGVGAGAYEMKPGDRVEWYYVSEDEEAKEEKEKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK93</accession>
    <name>A0A398CK93_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_25080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01619">
        <property type="protein sequence ID" value="RIE01619"/>
        <property type="gene ID" value="D3H35_25080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041617">
        <property type="entry name" value="TPR_MalT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17874">
        <property type="entry name" value="TPR_MalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="796"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="BTAD" evidence="5">
        <location>
            <begin position="879"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1018" mass="116590" checksum="AEE1AF75DC0BD152" modified="2018-12-05" version="1">MIVQTKIHIPQVRHALVVRPELLRLLDEGMHAKLTLVSAPSGYGKSTALSEWALQKGKLVAWVSLSKQDDDWIAFWEAAVESIRNRVDGFGRTVFPLLAEGPSSSSVSREPAMTALLNELERLPEELVILFDDFHLVTVPAIHDSMSYLIEHLPNSIHLYIASRNDLPFPTTKWFAQGELRLIMTEQLRFRPEEAADFFRETTELRLTVDQLDLLYGQTEGWITGLRLAALSMRRSGDVAESIRRFSGHQQHIADYLLQEVIRDLPEAIRDFLLQTCMLSQMNYALCEAVTGMAGAQRQLEQLEKLQLFIVPLDEQREWYRYHHLLSDFLQAMLARNAPELWERANVRAAQWFENQGFVQEAAEHYLAGRQYEDVVRLIETHLNEFLSGGKNVALARWAMQVPGPYLSDRPLVELFYLYAMVGTRQFEDVPDRAERLRIRFEALADRMDAAVWRGMMGEIYYICATAAYIAKDLAGTADYFIRGDAYARENSFFLQGGNNKHYSVEEFNDHLSYVNDYNGAALFLTRMIDHWRGHANHPFATPMYASYAKLLYEWNRLDEAEEWINRIMHADRFAPITSNRFQLVVAASRIQQAKGNGREAASMLERLKLMIDSPDYAIFMRKIEAEQASLAIRQGDLESARRWSTECGLSHEDEAALGKVSEQLALVRVLAADGLLEPALSLGERLYRMLTKEDRLRDRIHVLILLSMTLHKAGRREQALEKLGIALRLSEPQGFVRSFADEGSAMAELLSTIGESTANEARYARQVLRAFPVGRSSSRTKIRCFGRLRVETKSGETPKWRTSKTEELMALLLHHRGEAVSRDRILDTLWSEVDVERAGGQFHTTTHYLRKALQRIGLEGLVQHAKGGYRIEMSRLDCDLDEWDRLRTSAIQAEDNEVSQEAAELIDLYGEGYLAGHSYSWAEPMRIRIQSEYVGLLIDLQEREEKRGRYDAAAELLRQALSHDPLNERLHERLIRVLVLADDRVSAMKQYETLRTMLQAEFGMGPKEAVRRLLELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKB9</accession>
    <name>A0A398CKB9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal-independent alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_28295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00337">
        <property type="protein sequence ID" value="RIE00337"/>
        <property type="gene ID" value="D3H35_28295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901575">
        <property type="term" value="P:organic substance catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="PTHR31047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="108" mass="12224" checksum="1681A7358AF61682" modified="2018-12-05" version="1" fragment="single">MTATTFVLTGDIPAMWLRTRSSRSFTTFRLRPAIRGLQRIIGGLIKRHMACILIDPYANAFNETANDLALERSGRTDMGPWVWERKFELDSMCFSSGLLICIGRKPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKF1</accession>
    <name>A0A398CKF1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lasso peptide biosynthesis PqqD family chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03786">
        <property type="protein sequence ID" value="RIE03786"/>
        <property type="gene ID" value="D3H35_09540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="102" mass="11252" checksum="FA02E8CBE1CCA903" modified="2018-12-05" version="1">MATDTKLNATNYVLQGEGNVVSDMDGEKVMLSVSNGKYYNLGEIGGRIWDLIASPISIGQVVNLLLEEFSVDRAECERHVLVFLEQLSAEKLIHVGETVKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKT8</accession>
    <name>A0A398CKT8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1273 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_20550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02995">
        <property type="protein sequence ID" value="RIE02995"/>
        <property type="gene ID" value="D3H35_20550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010697">
        <property type="entry name" value="YspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38440">
        <property type="entry name" value="PTHR38440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06908">
        <property type="entry name" value="YpsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021290">
        <property type="entry name" value="DUF1273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="185" mass="21407" checksum="4897C9B1FDEF07CB" modified="2018-12-05" version="1">MKNLLVTGYRAHELGIFNRKHPGIGYIKKAITAKLVPLVEEGVEWVITPGQYGVDWWACEAVIELKKRYPQLKLSILTAFSNPEEKWNEDKQEHYREILRDVDYYGTVSKQPYSGVWQFTARDDLLLRKTDGILLVYDEDAGEGSPKYFKEKALRKNANGEYRYIGIGSEEIQSIADEHEYPAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKX8</accession>
    <name>A0A398CKX8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_Tnp_IS1595 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01879">
        <property type="protein sequence ID" value="RIE01879"/>
        <property type="gene ID" value="D3H35_13940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS1595" evidence="1">
        <location>
            <begin position="18"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="132" mass="14835" checksum="5AB69340337D7766" modified="2018-12-05" version="1">MNGVMRRLHTLSQIKTKSLEGIVEADETYVLYSEKGKRKLPRKTHKRGGVAKKRGISAEQVCILFARDRTKHTVAEVATFVRLSTATLDQLLSSRLQSGVILCIDEKPTFRKYAGERKLPPRSAPTVRENNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL52</accession>
    <name>A0A398CL52_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1146 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03135">
        <property type="protein sequence ID" value="RIE03135"/>
        <property type="gene ID" value="D3H35_14685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009526">
        <property type="entry name" value="DUF1146"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06612">
        <property type="entry name" value="DUF1146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="76" mass="8757" checksum="13C0845FBD5EFFE7" modified="2018-12-05" version="1">MGLNGLFAIFVTLGCIALAWILLQEVKWDAFVRNPRSPRARMIQVVLAVIVGHLMSRFFLDYWEWAGAMKWLFQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLQ3</accession>
    <name>A0A398CLQ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell division protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_11840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03365">
        <property type="protein sequence ID" value="RIE03365"/>
        <property type="gene ID" value="D3H35_11840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="151" mass="17772" checksum="7C491D1801B3C788" modified="2018-12-05" version="1">MVTVRTEMIIDAPIQVCFDLARNIDVHTQTVWRHTKERAVAGTINGLINEGETVTFQATHFFIRQKLTSKITEMKSPYYFIDEMMNGAFKSLRHEHLFEERNGMTLMKDILVFEAPFGMIGKVAERFVLKKYMKRFLEHRNFRLKILAENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLU5</accession>
    <name>A0A398CLU5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000034">
        <property type="protein sequence ID" value="RIE03623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03623">
        <property type="protein sequence ID" value="RIE03623"/>
        <property type="gene ID" value="D3H35_10635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="232" mass="24815" checksum="B6A2AE5A427532A9" modified="2018-12-05" version="1">MGNDRHLQRNDADYVLLSQIHKENQVLIRDGRNDSIIYLSTEDNLAIGEGTEFGGSHDEAYLYAEQVAVSGTFRLSHGIVSASRMSTLGEATFDLQGKPGLTPVEGADGTDGEDGGDFSLFIETAAADSPHFQMNASGGKGGDGKAGLSSDTKGGDGGNGGCGGNVKLLYGHPYLKLVAELRNIYQDEDEDDKVKKLIGILEENPDVALLEPFRQKLKDSASPETAMSSYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLU9</accession>
    <name>A0A398CLU9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01838">
        <property type="protein sequence ID" value="RIE01838"/>
        <property type="gene ID" value="D3H35_13695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="153" mass="16734" checksum="FF59CDD1E368E282" modified="2018-12-05" version="1">MGNQTEKEATAASLKLFVVLSKAYKAVMDHAVKDMKQHGLSPSEFTVLELLYHKGKFPLQQIGEKILVTSGSVTYNIDKLEKKGYLKRIPCDDDRRVTFAGITEAGQQLFDRIFPDHAAAIHSVMRGLSSEEKETAASLLKKLGLGVAKGDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLV4</accession>
    <name>A0A398CLV4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen-III synthase</fullName>
            <ecNumber evidence="2">4.2.1.75</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.75" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02199">
        <property type="protein sequence ID" value="RIE02199"/>
        <property type="gene ID" value="D3H35_15780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40082">
        <property type="entry name" value="PTHR40082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEM4" evidence="1">
        <location>
            <begin position="22"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="287" mass="31377" checksum="47CC4753DA7B9026" modified="2018-12-05" version="1">MGKLDGKHIAVTGPRCAEEFTRMVVKMGGQPFIYPAQGTVYSDDRMLEEQIRELTVKPVDWLVLTTGIGTEALVNKAEELGLRSELLAVMSSTRIAARGYKTVNALRKLDIAPTVKADDGTTDGVYRELAEFPLEGARIALQLYGDPSPKISVRLREAGAECVELMPYIHVMPDTGPLDELISRCIAGSLNAVVFTSTVQARCVFHRARETGQDELLLRAFEDGVVAVAVGKVTAEALFEEKVVRVLYPEEERLGPSLVGVGRWFEDNDAEQSVELDAAPLINTVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMB7</accession>
    <name>A0A398CMB7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_21435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01017">
        <property type="protein sequence ID" value="RIE01017"/>
        <property type="gene ID" value="D3H35_21435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="189"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="293"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="579" mass="67007" checksum="CA9D1668A8942D25" modified="2018-12-05" version="1">MSQRKRAASSRRSKVIPMRLDATFFFERAVQSLDRYHYDKALKYFRRAVEYEPENPVNHCNMAGILSEMGRYEESNVILRSVIDQIDPAMTECYYYLANNYANMEQYEAAEEALVHYLEHDEEGQFLDEADELLDLLGYELNRPTKLSTIKSRENLYAHDKARELLEAGRFAEAVRMLEEILVRQPDFVAVRNNLGLAYYYMGLFDKAISTISEVLEAEPGNLHALCNMAIFYQHGNQESPLRELLEKLRKTVPFHPEHVFKLATTLGIIGDHREAYRHFRRLIRTGELANEPSLHHFAAVAAVNLGRYNEAERHWNQAQKLDPNSSVAAFHLRRLPQVRSGEEKPPVHYHYHLPFEEQFRQWETKPGLVSEALKQDPLIRSSFFWALRHGDRKTKVQVIQALGLVADEEVIESLKAFLVDPKEEDELKRVAVLVLRSIGVQDSLSVTFGGRPLTLEARRKSERLPVWDSSWQIVLEQALEGMSGRYDVVQQHDMMTLWVDYLSRVYPEVPKLHKSSGWAAALEYWTAKMHRRTVTYSDLVDRYGASQASISRYANRIDEACGIREKLDLTSPSFRGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMR1</accession>
    <name>A0A398CMR1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 13">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="8">GluTR</shortName>
            <ecNumber evidence="4 8 13">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemA</name>
        <name evidence="17" type="ORF">D3H35_07950</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 13">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 13">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 13">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4 8 13"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03893">
        <property type="protein sequence ID" value="RIE03893"/>
        <property type="gene ID" value="D3H35_07950"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="16">
        <location>
            <begin position="6"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="15">
        <location>
            <begin position="171"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="GlutR_dimer" evidence="14">
        <location>
            <begin position="321"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="114"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="189"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="8 12">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RIE03893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="470" mass="52810" checksum="80408E8B747604E5" modified="2018-12-05" version="1">MHLIVVGLNYRTAPVEVREKFALSDSDMPAALKGLKQTPGILEGVIVATCNRTEIYAVVDRQQLCGHFIRSFMEQWFKLPRQQFNPHLYMYEDDRAVEHLFSVTCGLDSMILGETQILGQVRDAFLLAQEERATGTMFNRLFKQAVTLAKRAHSETSIGEKAVSVSYAAVELGKRIFGRFDDKTVMILGAGKMSELTAQHLHANGAKKVLVVNRTVARAEELAVKFQGTALGLEEALDRLNETDIIISSTGAQRFVLDRKTVEAAMARRKKKPLFLIDIAVPRDIDPACGDIPNVFLYDIDDLEGIVETNLSQRRKEASIIEDMIVVEQEAYRQWFATLGVSPLIRALQEKAAAVHENTMESLFRKLPELDERQAKVIRKLTKSIVTQVIHDPILRIKELAAEKRGDEAMSLFVDLFSLEEDVDRLRTEAKAEELARKESVVAVKAEEKHSSSVLRDVEHLLNQLAGAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMT6</accession>
    <name>A0A398CMT6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YheC/YheD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03923">
        <property type="protein sequence ID" value="RIE03923"/>
        <property type="gene ID" value="D3H35_08130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026838">
        <property type="entry name" value="YheC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38437">
        <property type="entry name" value="PTHR38437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14398">
        <property type="entry name" value="ATPgrasp_YheCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="410" mass="46332" checksum="43007E009C60947E" modified="2018-12-05" version="1">MALPSTPVLGILTLYLTDEGRLEERSVYEKMIAAGKRLGMTVFVFTPRDVDDRNGRISALVYRTDTKKWSRKWMKFPHVIYDRCRIQKSVRFQELLAFRKKYSHLTFLNRPLRNKWTVYRTLGNVSSFRSHLPSTRLFQSSDDVADMLKRFSTVYFKPINGTGGRGILRIDKERRGTLLLQGRNHSRSIVQAKRIQPGMLSAALRSWDKRGDRYIVQQGLNIKLPNGRVHDYRMLVQKNGRGEWEVTGCAGRIGPSQSITSNLHGGGQAASMNSLLRHWVGSEAKISQIRETAESFSISVARHLESTYSDLCELALDLAIDRNGRVWLLEVNPKPSREVFLKAGETDVYRKAIVRPIEYALWVYQQKRGSKSSHRSPSVASIRSVGGGGSYAAGFTGQNGDSAMAEGYPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMW9</accession>
    <name>A0A398CMW9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2500 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04696">
        <property type="protein sequence ID" value="RIE04696"/>
        <property type="gene ID" value="D3H35_04205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019635">
        <property type="entry name" value="DUF2500"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10694">
        <property type="entry name" value="DUF2500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="131" mass="14665" checksum="082079A0A8BEBB16" modified="2018-12-05" version="1">MGTGFSDMSGFGAMGGLFTVFFVVVIGFVAFRMIRGVAQWQRNNDSPQLSVDARIVSKRTNVNHHHHAGDAAHHSTTTSYYVTFEVESGDRMEFHVNGQEFGMLAEGDFGKLSFQGTRYLGFMRNRRAEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN15</accession>
    <name>A0A398CN15_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_08595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04003">
        <property type="protein sequence ID" value="RIE04003"/>
        <property type="gene ID" value="D3H35_08595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="5">
        <location>
            <begin position="131"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="199" mass="22239" checksum="5E9F92B7EFB8A0D4" modified="2018-12-05" version="1">MIRIVIAEDQRMLLGAFASLLNLEADMEVVGQAGNGEEAVALVHRHKPDICMMDIEMPVKNGLEAAEELRDFDCKVIILTTFARSGYFERALKGGVSGYLLKDSPIEELADSIRSVMAGRRIFAAELVDEAYREDNPLTEREKEVLGLMADGKNTKEIAGKLFITTGTVRNYISIILDKLKVSNRIEATMRVKEKGWFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN31</accession>
    <name>A0A398CN31_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000058">
        <property type="protein sequence ID" value="RIE00324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00324">
        <property type="protein sequence ID" value="RIE00324"/>
        <property type="gene ID" value="D3H35_29230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="291" mass="31210" checksum="1B0C3975F7B173D6" modified="2018-12-05" version="1">MGTKLGGRCGRSGSAAARLHRPVQSSRYRTRGRVLQGAGHSSVRAIAPADAGALPGRLLAAGKAVRRKARGMRLFERHDAGGNEILGRRYPVEGEGSGARPGRHSVLPRFVPVVAPTEREAREKFESYLEQVSTEGTLALLSSWSGIDFSAFGRDELLAFIERKGNGSQYIADYLSRASAERPLTVPDLAKLYAFGGIENVAVGSAEQIAERMIAFADATGIDGFNVAYAIRPASVRDFADLVVPELQRLGRVQSEYEAGSLRGKLFGHGDRLKPGHPGTRTELNANAPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN77</accession>
    <name>A0A398CN77_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RHS repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03935">
        <property type="protein sequence ID" value="RIE03935"/>
        <property type="gene ID" value="D3H35_08195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017353828" evidence="1">
        <location>
            <begin position="30"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="904" mass="102232" checksum="58920B793BA54297" modified="2018-12-05" version="1">MIRNVKKTFFSSILAIAMFLAFSGGSVQAAVNIQGLEGVLNNIASKQNNENQKPFLADRNSTEELIDPITGSLTLKQTDIVLPGKDGLDLSIARIYNSSMSEGATKKVTVTSSSSSSTTYSTLGWYVEVTRCYPGSTCSTFYLGPYTSESAAWLVENDYNYSTTNTSYIDFASRFYGQVQTTYSTYTVKTSNIPDKNNYLRSRYDLGTGWFLAFPSVQKEKYSGKTYLTFHDGTGASYSVEFTPDTSDSNLANYEGKDAEFRQIQTNDPVYGFNNSQVSAAYVFVSSDKRRTYFADDGRLVGIQDRFGNQITFKHTNRTVFGNTYPFISEIIDSVGRTVTFTYEDTINATNFNGENIDVLVKDPDNPSHTVSVRYIKDRRNVALLDSNDNVIETFFIPTLWQVVDRAGLVNSFSYQSPSQKVRFMFHTKSLNPSAYTFAILLAEARYPHSRSMYEYGATIRNLGPDGATDAYRVARRYDEVRRYNPNTATSYYTGNDPASNAKINDTSYAYTNDLTGYPTYSSTEVLPTSYLFSSEYMLGSGQKVKRTYNKKMQMVTAEVTTSSNEKKRVTYQEFDSNFKTKPTKLKIEDITSGGTAYNTQYIGQTYTDWGGLQSITQPLTSTQYQNAATKALYTTSFTYEPTYKMLTQKQWYQKAATLLTESYTFDTLGRILTYTNAANETTQYVYAQGPEGFRIEVTKPLENNKQAKSVRIYGPDGKFAFPTISKEYYTDSNNNLVESTSTKTYDLLLGLVRTDTNSEGATTTYSYDDLGRVTSIALPAYTGEDGNDYTMTQKYQYFPYRYSNYYDANNTQIINTVLESYIELQKVGESFGTTYNLQNQIYDGFGNPRQVQTYDDDNGWAITDYRYDKVNRPIYVKDAESNVATYSYDPWESWRKLSMLTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNH8</accession>
    <name>A0A398CNH8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03790">
        <property type="protein sequence ID" value="RIE03790"/>
        <property type="gene ID" value="D3H35_09560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="171" mass="18510" checksum="6A9386803268695C" modified="2018-12-05" version="1">MLKSKILLQLLRPGFWKFTIISLLKRYDEHSVAITKLGAYNGAIIDSTVSLKQPEQIYLGRNVHIGHGCVLWPGTGKITVSDDVLLGPYVQLFASNHGIRKDLLIERQEQHAKDVSVESDCWLGAGVIVVPGVTISRGTVVAAGAVVTKDTPPYSIVAGVPAKVISLRAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNK1</accession>
    <name>A0A398CNK1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pirin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_24395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01497">
        <property type="protein sequence ID" value="RIE01497"/>
        <property type="gene ID" value="D3H35_24395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041602">
        <property type="entry name" value="Quercetinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="PTHR43212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17954">
        <property type="entry name" value="Pirin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="15"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C_2" evidence="4">
        <location>
            <begin position="159"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="236" mass="25680" checksum="218942B777682FEA" modified="2018-12-05" version="1">MIKIYPAESTFSADLGWLKSRPSFSFGAYQDPDNSEFGVMRVCNDDEVAPGKGFGAHPHSDMEIVSIVLSGQIRHEDNLGNVAVSEPGEVQRMSAGTGVIHTEFNPSPDEWLRLLQLWFMPVKRGLPPSYETAAYDISGTVNALLPVVSGQGFEKPGSVASLQQDLTVYLGRLETGRELSFAQAEGRRIYVYVIEGVLDVAGGTELKVLDSARIDETPELAIAAKADAFFMLIDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNM3</accession>
    <name>A0A398CNM3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nodulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_03245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NodU/CmcH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04966">
        <property type="protein sequence ID" value="RIE04966"/>
        <property type="gene ID" value="D3H35_03245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031730">
        <property type="entry name" value="Carbam_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038152">
        <property type="entry name" value="Carbam_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003696">
        <property type="entry name" value="Carbtransf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16861">
        <property type="entry name" value="Carbam_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02543">
        <property type="entry name" value="Carbam_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbam_trans_N" evidence="2">
        <location>
            <begin position="25"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Carbam_trans_C" evidence="3">
        <location>
            <begin position="287"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="562" mass="64258" checksum="23284C5EC7615473" modified="2018-12-05" version="1">MDRDIKSYIQRLIFEEFQYLFELGKIVFVDHHLSHAVSAYSLSGFNSSLVLTIDGTGEGISGTVWSGNANRLELLQSYSDSNSLGFYYKEVIRFLGYEMFDEYKVMGLAPYGDPRRYRRFFKKFYTLLPEGQYEIHFENIYYLSNILSPRKKSEPFAQVHKDVAASLQESLEVIVSHILNYFKQKSGHQKLCLAGGVAQNCTLNGKILYSNLFEELFVQPAAHDAGCALGAALYIHDSVVPQEKTNKLEHLYWGSDIGEPEAIEKTLKEWSSWLEFKKEDHIEKKTATLLSEGKVIGWVQGRSEFGPRALGNRSILADPRPPENREVINAMVKLREGYRPFAPSVLEEYAPQFYEIPPGQNMFPHMIIVLRVKEEKRTLLGAVTHVDGSARVQTVNRHTNPKYWGLIHAFKELTDTPILLNTSFNNNVEPIVDSVYDAIICFLTTKIHFLVIGDFLISKIEADAKRFLPMRISLSPYATITQSKRHVSEKSESIFHEIGVVYSDKYTIPLSSELYRILLLSDGKRTLHSCLQEISPCDVTNEELVEEIQELWSRRLIVLYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNX1</accession>
    <name>A0A398CNX1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PhoH family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_06180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04205">
        <property type="protein sequence ID" value="RIE04205"/>
        <property type="gene ID" value="D3H35_06180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="3">
        <location>
            <begin position="113"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="323" mass="36060" checksum="EF7517A4F8D8FEEA" modified="2018-12-05" version="1">MSEQQISVTIPLQSAAEGLALFGPQDKFLRLIEKDAISLIRSREAEIFIEGPEKEVRSLEQLFETLQQLVRSGLQLSERDVRYAWELAREMKADALLALFKGEITTTYRGKPIVPKTLGQRHYVTTIRKKDIVFGIGPAGTGKTYLAVVLAVAALKEGRVKRILLTRPAVEAGENLGFLPGDLQEKVDPYLRPLYDALNDVLGADGVAKALERGMIEIAPLAYMRGRTLDDSFIILDEAQNTTPEQMKMFLTRLGFGSHMVITGDVTQIDLPKGKKSGLIEAQRILRNIEEIGIVYFSEQDVVRHALVQKIIVAYNQDNEQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP19</accession>
    <name>A0A398CP19_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 15" type="primary">rpe</name>
        <name evidence="15" type="ORF">D3H35_25125</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01627">
        <property type="protein sequence ID" value="RIE01627"/>
        <property type="gene ID" value="D3H35_25125"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE01627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="221" mass="24561" checksum="E9DFF0AA2732CC65" modified="2018-12-05" version="1">MVTIGPSLMCADLGRLIENIHQLDSAEVDFYHFDIMDGNFVPNITLGPDLIRSLRPYSNKPFDAHLMVEEPERFIDPIAKAGANMISVHAESKVHLERALQQIRSHGLKAGVALNPSTPLCELDYIMDSLDYVCLMTVNPGFAGQKFIPRTLRKIKDLKAKFEQEGLDISIEVDGNISNAIIPEVIKNGADMLVCGTSSIFIPKEPLEYSVAQVKQLINQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP51</accession>
    <name>A0A398CP51_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF58 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04152">
        <property type="protein sequence ID" value="RIE04152"/>
        <property type="gene ID" value="D3H35_05865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="1">
        <location>
            <begin position="68"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="175" mass="19710" checksum="5965D77E05BA0780" modified="2018-12-05" version="1">MLDERYIRAFRAPGLLRAAGRCHRHASYYRVEGMAAVSPFGQRNVSADVFLALGQGDDANRRSAGIHPRDRFSRIHWNATAKTGQWKSKEYEREALPRVVFVLDRNAASYRTPELFELALSTAASLVELSQQKGMQIGFVSAGRIASYFGSGHAGYRARRCCTIWSMPKRTARRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPA9</accession>
    <name>A0A398CPA9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DsbA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_06280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04222">
        <property type="protein sequence ID" value="RIE04222"/>
        <property type="gene ID" value="D3H35_06280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="2">
        <location>
            <begin position="72"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="250" mass="28037" checksum="9DEB9C81788DF0EF" modified="2018-12-05" version="1">MEKIERGRVNLAQKSQQKATVKQIKQQQQQKKQKRMRVLIWGIVVCFIALIAAAIILKPKAGVVDIAYDKVPTLGSVEAPVKIAEFGDFKCPTCQYFSKDILSQIKKDYVDTGKASFSFLNFTIIAQDSYTAALAGQSIYHQNKDEFWKFYDALYENQQADEQAAWATPDFLTELAKSNGVNVDYDKLRKDIDEGTYSGEIDKQNALARKKNFTGTPTVLINGKVLDSSVSLDYSKLKVELDKAVEEAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPI5</accession>
    <name>A0A398CPI5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000012">
        <property type="protein sequence ID" value="RIE05306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05306">
        <property type="protein sequence ID" value="RIE05306"/>
        <property type="gene ID" value="D3H35_01275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="84" mass="9125" checksum="813984C5FDF97F9B" modified="2018-12-05" version="1">MEKFRRKLFLDHSATLDAGFGPASVITVKFSRSASDCGFSTGSRITLTGWPFAFIVPIGTEFSIPCSWLAISPAFACDAFTLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPL7</accession>
    <name>A0A398CPL7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04352">
        <property type="protein sequence ID" value="RIE04352"/>
        <property type="gene ID" value="D3H35_07075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="127" mass="13765" checksum="51D24F5D78C316CC" modified="2018-12-05" version="1">MDLVLRNVIFAKKVNISNVPVLSCDSCGRNEVYPSVKADVGKLVGDLGSKPSTGTIPFDQVHEWAGVLSNALAEARTLQAAAIARASEERVNQLLDLWLIASSLGDEAWKSELKQRLSQLSAPYITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPN6</accession>
    <name>A0A398CPN6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="15">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D3H35_13740</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 15">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 16">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 13">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="15"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01847">
        <property type="protein sequence ID" value="RIE01847"/>
        <property type="gene ID" value="D3H35_13740"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050048">
        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="PTHR11825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 15 17" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15 17" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RIE01847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="358" mass="39583" checksum="A10D2E298EE441C9" modified="2018-12-05" version="1">MNTPIIVNESTDKKAKPSADQLGFGKYFTDHMFIMDYDSGLGWHDPRIVPYQPIVLDPAAKVFHYGQTVFEGMKAFVASDGRILLFRPEKNLRRLNFSNHRMSIPQLDEEVALEAIRQLVLLERDWIPAEPGTSLYVRPFVIATQPALGVAPSEQYRFIVILSPVGAYYAEGINPVSIYVEPEFVRAVAGGVGNAKTAGNYAAGLIAQQEASRQGYSQVLWLDGVHRTYIEEVGSMNVFFKVGDTVLTPELNGSILDGVTRDSVIRLLKHWGIAVEQRRISIAELVEAQRNGSLTEAFGTGTAAVISPIGELYWQGEKFSVNEGRTGDLSAKIYDALTGIQRGTEPDPFGWMLELSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPQ7</accession>
    <name>A0A398CPQ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_00770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05396">
        <property type="protein sequence ID" value="RIE05396"/>
        <property type="gene ID" value="D3H35_00770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="3">
        <location>
            <begin position="24"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="218" mass="24774" checksum="FB1F9A02688EB174" modified="2018-12-05" version="1">MVEFEAKRLAAQSGSHRTFYAPAKRAMDFMGALCGLILLSPVFAVVAALVKLEAPRAPVLFYQTRIGKHAKPFRMIKFRSMVPDAEQKLGELLGKNEIKGAMFKMKEDPRITRIGKFIRKTSIDELPQLINVLKGEMSLVGPRPPLPREVAQYSEYDKLRLTVNSGCTGLWQVNGRNRLSFEQMVELDLEYIRQRSIRGDLKIIFRTFKLLLGAKDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPT5</accession>
    <name>A0A398CPT5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Small acid-soluble spore protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02748">
        <property type="protein sequence ID" value="RIE02748"/>
        <property type="gene ID" value="D3H35_19075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001448">
        <property type="entry name" value="SASP_alpha/beta-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038300">
        <property type="entry name" value="SASP_sf_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00269">
        <property type="entry name" value="SASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="68" mass="7037" checksum="4F971826F0877A5F" modified="2018-12-05" version="1">MAGNNQVLVPQAKAALNSMKTEAAQSLGVQIPADGYYGNVTSRDAGSLGGYITKKLVQIAEQQLSGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPU7</accession>
    <name>A0A398CPU7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">recO</name>
        <name evidence="9" type="ORF">D3H35_06215</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the RecO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04210">
        <property type="protein sequence ID" value="RIE04210"/>
        <property type="gene ID" value="D3H35_06215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042242">
        <property type="entry name" value="RecO_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_rep/recomb_RecO_N" evidence="8">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="279" mass="31264" checksum="6E45C006F682E367" modified="2018-12-05" version="1">MLYRVEGIVIRSTDYGEGNKIVTLLTSTHGKQGVIVRGARKPKSRFGAAAQLFTCGDFSFYKTGSLGTLNNVEVLEPFRQLRQGLEGPAYAAYACELTDRAVDEEEAGEYIYYQLKACLAALAEGKDPQVVLRVYEMKMSSAAGYMPILTECAGCGRRDVPFRFSPAVGGALCGNCRHRDPYALELDEPVWKLLRLFAALDMRRLGGVELKESSKRQLQFAMRRWMDAHLSLNLKSRGFLDQLERHGEMLGLKQEPGFDTAVRPPETTMRVIDIRRAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPU9</accession>
    <name>A0A398CPU9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dxr</name>
        <name evidence="11" type="ORF">D3H35_11565</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03319">
        <property type="protein sequence ID" value="RIE03319"/>
        <property type="gene ID" value="D3H35_11565"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="8">
        <location>
            <begin position="4"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="9">
        <location>
            <begin position="143"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="DXPR_C" evidence="10">
        <location>
            <begin position="258"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE03319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="380" mass="40514" checksum="5D14A768F7928875" modified="2018-12-05" version="1">MKKVSVLGSTGSIGTQTLDVISRDPDSYEVVGLAAGSNIELLLEQARAFKPKLVSIATKELAERIRGELPPGVRVVYGEDGLNEVAAGVGADYVACALVGSLGLTSTLAAIEAGATIGLANKETLVTAGHIVMKRAADKGVAIVPVDSEHSALFQCLNGERLRDVKRLVLTASGGSFRDRSRDELGGVTVADALRHPNWSMGAKVTIDSATMANKGLEVIEAHWLFDMPYDRIDVLIHPESIVHSMVEFEDTSVMAQLGNPDMRVPIQYALTYPERRSSPASALDLLAKGTLHFRPMDFSRYPCLRLAYEAGKAGGTAPTVFNAANEIAVSRFLKGETAFLAIDEIVESVLASHSVLASPDLETILATDAWARSEASRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ12</accession>
    <name>A0A398CQ12_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">(S)-benzoin forming benzil reductase</fullName>
            <ecNumber evidence="1">1.1.1.320</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_11985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.320" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03389">
        <property type="protein sequence ID" value="RIE03389"/>
        <property type="gene ID" value="D3H35_11985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102306">
        <property type="term" value="F:benzil reductase [(S)-benzoin-forming] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="251" mass="27454" checksum="A304BDE2964E6D3C" modified="2018-12-05" version="1">MKYYIVTGTSRGLGEAIAEKLIASGNHITCISRGANERLVKLAEDRGAELNYISFDLSRSNEIEAVMRAIFAKIDKENAEAVILINNAGILAPIKPIESCSSEEIILNNQINLVAPMILSSSFIALAADIRADKQIVHISSGAGKKPYFGWSSYCSAKAGLDMYTRCAAVEQQDKEYPVRVVSFAPGVVDTAMQQEIRSTGKEYFRDIERFIALKEEGVLLTPEYAADKLLSVIASSDIENGAILHISQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ52</accession>
    <name>A0A398CQ52_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF664 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DinB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01561">
        <property type="protein sequence ID" value="RIE01561"/>
        <property type="gene ID" value="D3H35_24750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007837">
        <property type="entry name" value="DinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37302">
        <property type="entry name" value="PTHR37302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05163">
        <property type="entry name" value="DinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="151" mass="17511" checksum="624ED4F2AE0CF783" modified="2018-12-05" version="1">MKTIKCMMEHMYWADERILDALKESGTKDKDLLKLVRHVAAAERVWLSRLQGKGSAPYSLWEEAEDLTAIRTMFEENAEQYRVYIEGLEESELDEMVDYANQSGVPFRTSVRDILSQVLLHGQYHRGQINRGLRIESAEPAQVDYITFARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ86</accession>
    <name>A0A398CQ86_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_20175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02928">
        <property type="protein sequence ID" value="RIE02928"/>
        <property type="gene ID" value="D3H35_20175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="175" mass="19853" checksum="A24F6FBA552C689F" modified="2018-12-05" version="1">MSAQSVHMKQFEEAKILHYKGVDGDKKAVIKANEMLLKLREAEPDNAQIEAYYGSTLVLLGRDAVKVLDRADKAEEGLDALNRAVSLDSNHKEIRLLRGNICLRLPESFFHCSETAIEDFTFLLDRYKENSGYLTPKQVREVLRNLAAAYQNAGKPDKADTVLQRIVEFERKKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQD1</accession>
    <name>A0A398CQD1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_04485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04745">
        <property type="protein sequence ID" value="RIE04745"/>
        <property type="gene ID" value="D3H35_04485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017357665" evidence="1">
        <location>
            <begin position="29"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="25"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="140"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="253" mass="28190" checksum="927DF27F863BECCC" modified="2018-12-05" version="1">MKAMKKLVASLMMFTVIFGISFVGSAFASGNEVKLIDSTVFTYKYGYVSFNGNVEVENLGYSKQVTIHYTTDNVTWYDTSASYVGPTDGTHEKWSFNISTSSFTTDHPELKTLTFIKFAVKYEVNGNTYWDNNGGSDYYNEPYSFGSTSLILAKPNLLGNYGELTSSGTFVGNVYVKDLSPSKTVKVRYSTDNWATYTEGYATYTSDVNNFGSVELWSFSFSVPGATHLEYAFAVTVGSTTYWDNNYGNNYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQI1</accession>
    <name>A0A398CQI1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_07495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04420">
        <property type="protein sequence ID" value="RIE04420"/>
        <property type="gene ID" value="D3H35_07495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="188" mass="20352" checksum="45F5A817918CE46C" modified="2018-12-05" version="1">MAIGVAAALLFHLVPWLKAAFAPLIVISQNIPVVAIGPLLIVWFGFGLTPKLILLVLVCFFPIVMSMMTGLSRSEPHLREYLAMIGASRMELLRRLELPASLPHFFTGLKITATYSVSTAVVVEWLGGSKGIGKYMLLKKASYDAAGVFASVIWVVALSLAVYGLVLLAERLVVRWTPRTGNQGGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQV6</accession>
    <name>A0A398CQV6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D3H35_17765</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03178">
        <property type="protein sequence ID" value="RIE03178"/>
        <property type="gene ID" value="D3H35_17765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="291"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="450"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE03178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="564" mass="64066" checksum="B48242547D85F701" modified="2018-12-05" version="1">MTVLVVFFVSAVLYDKFNQTAENNTSLANQQVIYQVAINLDSYIRSLTITFNAIESKIQNADGEFQGLKLTEQLDTIFSTREDLVTVAVFTEDGERLGALPAADMRTNTHLTSQSWFRSAVENPNHLSFSVPHVQNLFKDRYKWVVSMSKGIKLNIDGVEKNAVLLVDANFKRIDDLSRSVKLGQKGYAYIIDESAGNIIYHPQQQLIYAGLKYENVEQALSFSFGSFFDNSTGVDRLITIQTVGNVGWKIVGVSYMDEIVTTRKEITSFLGWLLGAVMIFVLLITWYMSAKISQPIKRLEKSMQLVERGNFDITIPIRRDDEVGRLSRRFNLMVTRIRELMGQNIQEQEAKRKSELEVLQSQIHPHFLYNTLNSVVRLAGTGKTDEVIRMITSLSKFFRISLSRGQHIIPVADELEHIRNYLIIQSMRYKNKFDYTIEAEEEALECRTMKLVLQPIVENAIYHGIEPGADDGHIFITASIVDGKLRMRVRDDGIGMAQNKLASLLAQDAGGKVSEGSGIGLRNVHERIRLHFGEEYGLRIESEREEGTTVDIWLPCLKEEMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR28</accession>
    <name>A0A398CR28_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsK</name>
        <name evidence="9" type="ORF">D3H35_02375</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05015">
        <property type="protein sequence ID" value="RIE05015"/>
        <property type="gene ID" value="D3H35_02375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE05015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="132" mass="14242" checksum="5B3A5BAFB3366020" modified="2018-12-05" version="1">MAQKGKKVVRTKRRDRKNIDTGVAHIRSTFNNTIVTITDPHGNAISWASSGNLGFKGSRKSTPFAAQMAAETAARAAMEHGMRVVEVMVKGPGAGREAAIRSLQAAGLEVSMIKDVTPIPHNGCRPPKRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR33</accession>
    <name>A0A398CR33_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE04982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04982">
        <property type="protein sequence ID" value="RIE04982"/>
        <property type="gene ID" value="D3H35_02200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="88" mass="10250" checksum="AC08C9C95D88CD60" modified="2018-12-05" version="1">MRALIVYQLKHYIRSYRYFPPLLLYIVSIVFIYGIVPNPVMESYSLTSAVLFLFSAWLGFSYIDSEHEIQQMIASSHAATSLNIIWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRI1</accession>
    <name>A0A398CRI1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phage_base_V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02437">
        <property type="protein sequence ID" value="RIE02437"/>
        <property type="gene ID" value="D3H35_17180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="1">
        <location>
            <begin position="54"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="232" mass="24052" checksum="CD000DCF3B4F484B" modified="2018-12-05" version="1">MSDLVALLRQLIRAELSRHTPSHIGIVEAVKDHAGPEDSVNYSCDVRLRESNVVLGEVPMASPLLGSVSPPAVGDLVLVHFVGGNPDFPIIGGRLYSDALRPPKYAQGQSVLSLPPAAADGARIDMLLQGGTEGSRSLSIKLPDKISVTISDQTISLATDSLKLTLDSDGKKASIETGAASISADADGNVVVQGSSSVQIKTDGNLEIKSNGNLTLNAVGEVQIQGAAIKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRI8</accession>
    <name>A0A398CRI8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_17230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02447">
        <property type="protein sequence ID" value="RIE02447"/>
        <property type="gene ID" value="D3H35_17230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="7">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="224" mass="25599" checksum="54F91D5080A8BF0E" modified="2018-12-05" version="1">MSPSILIVDDEVDILNMLRDYFELTGYRVMTAAGGREAVRQAEKQPDLILLDIHMPDFDGLQVCGQIRHFVSCPILFLTARVEDSDKIKGFGVGGDDYIVKPFSIDELGARVAAHLRRERRHYESSKVKFDSDLVIDYSERLLYFRGETVSLAKKEFGIIELLSQHAGQIFDKERIYERLWDFDNGGSSSVVAEHIRRIRAKFASSGMKPYIETVWGVGYKWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRR0</accession>
    <name>A0A398CRR0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_01785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05275">
        <property type="protein sequence ID" value="RIE05275"/>
        <property type="gene ID" value="D3H35_01785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="345" mass="38856" checksum="E571B58F370E69BD" modified="2018-12-05" version="1">MTKQDDKYAALTLDELFSKRDNPAAEPIPPREDEHEFVFEGSPKFETSCESDGSQIRIRGTGDLNLVEPLALVGDTLSIEELIQFSEKVSTPKAFRPNWLDVMTAPRIRPRFLDINIPGVIKPLIFESTGTEWPWSAIGKVFVTRRGKPTMVGSGVLVGPRLLLTASHVMPWDTKDSSIRFVPGYRNGNDPRFGHAYVDEWRGVRNTDSVTGLDYVICKLNWRIGERTGWLGSEWHSDEDWYYDNAWISVGYPTSEPNGGERPSIEIPVWVRDIDNESDGLEIETHKFALGGWSGGPLWGWRGGDPKVVGIESGYEKDFLDPTRTVFAGGQHLVNLVKYGWANWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRR7</accession>
    <name>A0A398CRR7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03488">
        <property type="protein sequence ID" value="RIE03488"/>
        <property type="gene ID" value="D3H35_12635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="168" mass="18054" checksum="B3F574F23A06B542" modified="2018-12-05" version="1">MLATGGVEWPEEACRPAALNANGYAGIRFLLRLSLEGAQFMKELLVRDTWPVRAQAELELTGIAPRLPVKIAFDPPLLHRLLAELCDESGLVSRSALVQFFSKEPAAIGLTLDGEPGSSGELAETLADWVRSRYGSFAAAPLADGLGYLALNLPNEGSGGWNGIYRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRT6</accession>
    <name>A0A398CRT6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Flagellar biosynthetic protein FliR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">fliR</name>
        <name evidence="11" type="ORF">D3H35_11455</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Role in flagellar biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the FliR/MopE/SpaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03508">
        <property type="protein sequence ID" value="RIE03508"/>
        <property type="gene ID" value="D3H35_11455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006303">
        <property type="entry name" value="FliR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002010">
        <property type="entry name" value="T3SS_IM_R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30065">
        <property type="entry name" value="PTHR30065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01311">
        <property type="entry name" value="Bac_export_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00953">
        <property type="entry name" value="TYPE3IMRPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01400">
        <property type="entry name" value="fliR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0969">Cilium</keyword>
    <keyword evidence="11" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE03508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="261" mass="28689" checksum="EAA0E55955BEBDFD" modified="2018-12-05" version="1">MDIVMQLIPAFMLVFCRITSFFVVAPVFSTKTVPAVFKIGLAFFVSIIVFLTVGFDSKVPTDATYIMAVMKEVLAGLVIGYVTYLFFTIVQTSGAIIDMQMGLGIANIVDPISGVSVPMTGNLKYMIMLLVFLSINGHHYLLSAIMDSYRWLPLDNNLFHTVSEGGLAEFLARTFADTFMLALQISAPLVVAMFLTDVGLALLARTAPQYNVFVIGVPLKILVGLAMLVLLLPGFGVLFQMIFDHMFQALDKLFVVFQKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRW1</accession>
    <name>A0A398CRW1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000013">
        <property type="protein sequence ID" value="RIE05293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05293">
        <property type="protein sequence ID" value="RIE05293"/>
        <property type="gene ID" value="D3H35_01320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="189" mass="21320" checksum="6F21E675BE43E0AD" modified="2018-12-05" version="1" fragment="single">MNKALPILIEMFKEQYPNVEFRLFGMGTNNEDLLQDLASFGVHADIVIMNDGDMQRLPLDKFLTLEDIVPEQGMTQDKLFQIFGHPTGQYAIPLTYSPVFLACNPHLFETSGLHIPQISWNWEQFCRSGQVDHKRFERRRPTTSTASVCPRRCIAGRARPQAQLSDAAGAVRHAEYRGAGGFFGLHPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS00</accession>
    <name>A0A398CS00_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family DNA-binding transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_12960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01714">
        <property type="protein sequence ID" value="RIE01714"/>
        <property type="gene ID" value="D3H35_12960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="344" mass="39305" checksum="E2341910FAE51047" modified="2018-12-05" version="1">MDQSKRLTVKELARQIGVSVATLDRVLNNRGNVKPDTYRMVMEKIKEMNYTPNKSASFLSRKNEYVMAIVFPELPEYFWNQVERGVQTAIDEFRDYGLHVHIIRSEKYDLDRQKAIFMELIESGKYDAIAISPNDPQEFADIIDHGVDRGVAICTFNSDSPLSKRLFYVGCDYRVAGRLAADVLCKLIGSKTRVGLIMSYTNFQMQQKVTGFREVVGEYDHIELIGPLKLQQEDYDSLDTFIDYFRQVDGIYVSSAKLDRVAKHLADANLSKPIALIGHDMTEEIYGHLRKGVVTATICQDPVNQGYLTVKSMFDYLVSGEKANEKENITKLELVTKENARYYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS78</accession>
    <name>A0A398CS78_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000004">
        <property type="protein sequence ID" value="RIE05455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05455">
        <property type="protein sequence ID" value="RIE05455"/>
        <property type="gene ID" value="D3H35_00380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="124" mass="13834" checksum="E53525E41AE4F88B" modified="2018-12-05" version="1">MNSWFTERRETRELIWIPHLVLTGAQLGRSAESTGSRVDPASREGSERDEAASLIGETDSVTSQERSLSDSVAGGRSSRRNAGIGSRHRTQRQGKRHLPFRFEFARLSPIRLGGFRASNGVIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSD6</accession>
    <name>A0A398CSD6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02707">
        <property type="protein sequence ID" value="RIE02707"/>
        <property type="gene ID" value="D3H35_18825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="79" mass="8434" checksum="133873B4129A3155" modified="2018-12-05" version="1">MPFATQKPQEKLAEASLASFTDAVSRAGDGPRERCETVVAAGIQAWDGSGRLNPGGYATRAQAPRIAVERLLQKLGFMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CST1</accession>
    <name>A0A398CST1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MBOAT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_16845</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02381">
        <property type="protein sequence ID" value="RIE02381"/>
        <property type="gene ID" value="D3H35_16845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024194">
        <property type="entry name" value="Ac/AlaTfrase_AlgI/DltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028362">
        <property type="entry name" value="AlgI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500217">
        <property type="entry name" value="AlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016636">
        <property type="entry name" value="AlgI_DltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE02381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="466" mass="53650" checksum="E1C10BBF71566651" modified="2018-12-05" version="1">MVFSSILFLYFFFPVLLLAYFVVKNTKFRNWILIVFSFAFYAWGEPVWVFLLVAASLLGYLASLYVDKHRGTRKGKLVFIVSICLIIGMLGYFKYTGFLIDNVNELLGLEVARPNIALPIGISFFTFEIICYMSDVYKGAIRAPRSPMKMFLYVSFFPHLIAGPIIRFTDIEAQMDNRKISLANFSSGVNRFVIGLGKKVILANSVGEIVPNLLGPNGSDSFLGVWFGVCLYALQIYFDFSGYSDMAIGLGKMFGFTLNENFNYPYISKSAGEFWRRWNMSLGGFFRDYVYIPLGGNRKRYIRNVTVVWFLTGLWHGASWNFIIWGLYFGLLIVLERYFLLKWFSKLPAFFSNLYFLGAMLVGWVWFYFTDIHEALMTLRIMFFLEERPIVSTQAFLFFRENMFLFFLAAISCTPLMKNAVSYLAGNRRTSPLVNTIGPVYNLAVLALCTILLVGSTYNPFLYFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTG0</accession>
    <name>A0A398CTG0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Alanine dehydrogenase</fullName>
            <ecNumber evidence="3 6">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ald</name>
        <name evidence="12" type="ORF">D3H35_05500</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18405"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="1.4.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="3 6"/>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04549">
        <property type="protein sequence ID" value="RIE04549"/>
        <property type="gene ID" value="D3H35_05500"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00527">
        <property type="reaction ID" value="UER00585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05305">
        <property type="entry name" value="L-AlaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008141">
        <property type="entry name" value="Ala_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795">
        <property type="entry name" value="PTHR42795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000183">
        <property type="entry name" value="Alanine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00518">
        <property type="entry name" value="alaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="10">
        <location>
            <begin position="149"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="299"/>
            <end position="302"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE04549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="371" mass="39097" checksum="3DFD11E263B9D03E" modified="2018-12-05" version="1">MIVGLPKEIKKQEYRVALTPAGAGMLARQGHEVIVQEGAGVGSGFADEEYAQAGATLVAGPEAVWEKAELIVKVKEPLPEEFGFFRAGQLLFTYLHLAAAVPLAKALTERQVTAIAYETMQAPNGTLPLLTPMSEVAGRMSVQEGAKYLEAFHGGRGVLLGGVPGVPPADVIIIGGGIVGTNAAKMAIGLGANVVVLEKNGDRMRYLDDVFQGRLRTLTSNPHNIASAVRKADLLIGAVLVPGARAPRLVTEEMVKTMKKGAVIVDVAIDQGGSIETIDRVTTHENPVYEKHGVIHYAVANMPGAVPRTSTLALTNVTIDFVLLLAANGFRKAVEASPMLGLGVNVHRGAVTHRQVAEAVGFPYTPLDGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTS7</accession>
    <name>A0A398CTS7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD_binding_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03267">
        <property type="protein sequence ID" value="RIE03267"/>
        <property type="gene ID" value="D3H35_11240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_5" evidence="1">
        <location>
            <begin position="14"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="118" mass="12853" checksum="051D0F0DD2E983B9" modified="2018-12-05" version="1">MSNIHGSSFRYPEVWRPADPAEAWQWKRRFGAEAAFAAGATWLRTQWEAGSLPMPSYLIDLSAVKELTGIKVKHNRLTIGALTSLAQVRSSAEVLANAPALTAAAAAIAAHSIRQLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUP7</accession>
    <name>A0A398CUP7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03587">
        <property type="protein sequence ID" value="RIE03587"/>
        <property type="gene ID" value="D3H35_10935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="131" mass="14487" checksum="A48A3D081FE58B7D" modified="2018-12-05" version="1">MPPKKNGERETLKFSELYGEMTVRGMKLSDKVNRLNGQQVEMTGFMAPPLSATVRFFVLTKVALAICPFCSTDADWPTDIVVVFMPDGKELTPTEHQVKVTGTLSVGSQTDDETGFVSLIRIMADKTEVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUU4</accession>
    <name>A0A398CUU4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">metE</name>
        <name evidence="13" type="ORF">D3H35_10065</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21196"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58140"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
            <dbReference type="EC" id="2.1.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="10"/>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03637">
        <property type="protein sequence ID" value="RIE03637"/>
        <property type="gene ID" value="D3H35_10065"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 10 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Meth_synt_1" evidence="12">
        <location>
            <begin position="8"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Meth_synt_2" evidence="11">
        <location>
            <begin position="433"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-methyltetrahydropteroyltri-L-glutamate binding" evidence="10">
        <location>
            <begin position="18"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-homocysteine binding" evidence="10">
        <location>
            <begin position="438"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-methionine binding" evidence="10">
        <location>
            <begin position="438"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-methyltetrahydropteroyltri-L-glutamate binding" evidence="10">
        <location>
            <begin position="522"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="701"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="568"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="606"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="648"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="650"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="672"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="733"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE03637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="762" mass="84304" checksum="2164D18AF62036BE" modified="2018-12-05" version="1">MANVLTAGLGYPRIGEQREWKKGLEQFWAGKQDEEAFRKEMRELRIRRLLRMKESGVALLPSGDFTLYDSMLDHIAAFDLVPERFRKFGASDSLAVYFAMARGKEGAPACEMTKWFDTNYHYLVPELASKPQPRLAFNPWRDAFLEAKEEAGLTTRPVLIGPYTFVRLAKGVAKGEFANVVRSYIAVYNAVLAELAQAGAEWAQLDEPSLVTDVPEEHLALLHEIYDGLKTANPGLKLHLQTYFGSVEHAESVFALPVDGIGLDFVRGGEENLKAVKTVGWSTGKKLGAGVVDGRGIWRVDPDRALTVLEALAALVPAGDLIVQPSCSLLHVPVTSKVETSGDPVVRESLAFADEKLQEIVSLAEAFEARLSGNGAAALPARLEENRTALEALRNHPGRQRAAQAATADASSARAAFAQRHVLQRERFKLPLLPTTTIGSLPQTAEVRKARLDWRRGKLSENDYRSLINGLIETWIRRQEELGIDVLVHGEFERTDMVEHFAHLLDGYYFTSNGWVQSYGSRCVKPPVIFGDVVDRGPMTVAETVYAQSLTDRPVKGMLTGPITMLAWSFYRDDLSRREIAEQIARALDAEVLRLEAAGIGMIQVDEPALREIAPLKKSEWPAYLDWAVEAFRTSVSGVRNETQIHTHMCYCDYHEIIDAVEAMDADVISLETSRSHGSLITALHDQPYGNGIGLGVYDIHSPVVPEVSTMLDVIRDSLAVVPADRLWVNPDCGLKTRGEPETIAALQRMTEAAALARQSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW38</accession>
    <name>A0A398CW38_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)H:quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_12200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03421">
        <property type="protein sequence ID" value="RIE03421"/>
        <property type="gene ID" value="D3H35_12200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="204" mass="21513" checksum="D71526CA8007021D" modified="2018-12-05" version="1">MANVKLAVIYYSSTGTNYQLAQWASDGAKETGAEVKVLKVPELAPESAIAGNPAWKAHVDATKDVPTVTLVDLEWADAIIFSVPTRFGNIPAQMKQFLDTTGGLWFQGKLANKVVSAMSSTSNLHGGHEATILALYTTMYHWGAIVAAPGYTDPVTFAAGGNPYGTSVTVGQDGKMTEDVQAAVKHQAKRTVTVAGWVKQGSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW48</accession>
    <name>A0A398CW48_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LexA repressor</fullName>
            <ecNumber evidence="12">3.4.21.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 16" type="primary">lexA</name>
        <name evidence="16" type="ORF">D3H35_04630</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of Ala-|-Gly bond in repressor LexA.</text>
            <dbReference type="EC" id="3.4.21.88"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the peptidase S24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="12"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04768">
        <property type="protein sequence ID" value="RIE04768"/>
        <property type="gene ID" value="D3H35_04630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00015">
        <property type="entry name" value="LexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 12" id="KW-0742">SOS response</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="LexA_DNA_bind" evidence="15">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="14">
        <location>
            <begin position="86"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="12">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="12">
        <location>
            <begin position="93"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RIE04768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="206" mass="22938" checksum="5C629BCDDAA08010" modified="2018-12-05" version="1">MSKMSNRQNAILEFIKTEVREKGYPPSVREIGEAVGLASSSTVHGHLDRLEKKGLIRRDPTKPRAIEILDDDVVAPYFTSNVRQIPVVGKVTAGVPITATENIEEYFPLPVHMVGDQTVFMLSVRGDSMIEAGIHDGDFVIVRQQPTATNGEIVVAMTEENEATVKTFYKERDHIRLQPENESMQPIRLKNVSILGKVIGLIRSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWA9</accession>
    <name>A0A398CWA9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chemotaxis protein CheA</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D3H35_11485</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03304">
        <property type="protein sequence ID" value="RIE03304"/>
        <property type="gene ID" value="D3H35_11485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037052">
        <property type="entry name" value="CheA-like_P2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010808">
        <property type="entry name" value="CheA_P2-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035891">
        <property type="entry name" value="CheY-binding_CheA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02895">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07194">
        <property type="entry name" value="P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01231">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55052">
        <property type="entry name" value="SSF55052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HPt" evidence="14">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="302"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="13">
        <location>
            <begin position="554"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="10">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE03304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="685" mass="74589" checksum="2375E900EE627231" modified="2018-12-05" version="1">MEMNQYLSIFIDESNDHLQALNENMLKLEQQPQDISIVQVIFRSAHTLKGMSATMGFEDLASLTHEMENVLDLVRNEKLSMNEAIFDTLFKGLDALEGMVQDIIGGGTGKADVSELVSRLKAIVKGDIGGSSSPAKTTGANVGVPHSLVLDQFQQSVLEQSLESGHRAYHLEVTVNEDCLLKAARAYMVFDVLERNGEVIKSSPSVQEIEQEQFDRSFSVYYISQAEEKSLLDEVSRVSEIESVKLTAIDKAYLNDLNKASGTAAAAAKQAQKETAAASAAPAQPENAAPRPPQQAAASGSAAPRTIRVDIDRLDTLMNLFSELLIDRVRLEQLASEVKRNDLTETVEHMARVSADLQNIVLKLRMVPIDNVFNRFPRMVRDLAKSLDKKVDLVITGAETELDRTVIDEIGDPLVHLLRNSVDHGVESISDRVAAGKREVGTVNLRAYHSGNHVFIEIEDDGKGINRPKVLEIAIKRGVVKPEEAAKLSDDEANMLLFAPGFSTADKVSDISGRGVGLDVVKTKIESLGGHVTVTSVIGAGTKFSIQLPLTLSIIAAMLIKLGSEKYAFPLSSIVETAAIRREQIRSLHGQRVIDYRNSIIPVLSLAELVESPDYRDSDEEETEVLVIRKGDKLAAVLVDEFIGQNEIVLKALGGYLTGLDIISGATILGDGQVALIIDPNALIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWI8</accession>
    <name>A0A398CWI8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_03490</name>
        <name evidence="2" type="ORF">D3H35_13175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000021">
        <property type="protein sequence ID" value="RIE04928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01751">
        <property type="protein sequence ID" value="RIE01751"/>
        <property type="gene ID" value="D3H35_13175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04928">
        <property type="protein sequence ID" value="RIE04928"/>
        <property type="gene ID" value="D3H35_03490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="189"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="273" mass="31021" checksum="D24AEF9D734624EC" modified="2018-12-05" version="1">MRSGYQPIQSPRFQRNLQHSGYKYREYAPSESLASHVACYWTMDFHAGDGNQVHRILPDGCVDIIIDLRSPSCRKAAFVAGLMAQYEVMTLTEAQSSFGIRFFIESAQTVLKFPVSAFIGSPIFLEDIWGEEGLFIVEEILAADTASEIVEIVERRLNLLFSCNVVSSSSLLHASMQYMYAFKGSISPSELAEKLSFSERHLRRIFDRELGMSPKEMLGIVRFQSMLQELHSGVHSSFTDIAMKYGYYDQSHFIKSFKRYYGLLPKQLGKIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWK4</accession>
    <name>A0A398CWK4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000035">
        <property type="protein sequence ID" value="RIE03591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03591">
        <property type="protein sequence ID" value="RIE03591"/>
        <property type="gene ID" value="D3H35_10655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="247" mass="27656" checksum="3C824A28ECDDA321" modified="2018-12-05" version="1">MTGEVEVGLDDEHNRSAEKVPFTARMTDLAGETFEYRHSFDPAKGGYRVSLRNSIESPLRIERLGIQLTADGNETAFELRDAVFPVERLASGEELVFHDCSADGCGGSKPGRHCYRSRGRRHGNADREAIWNAIQESYTAQYLQIIKVKTLPAIFQLPEGRPEAERLSEIVVELKRDGERSVSVSLNPESLEVEASLPFPIGDVILRREDSGEYSCKVTAIRLSGETVKDWKKKTGDRLFILQDDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXG2</accession>
    <name>A0A398CXG2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03674">
        <property type="protein sequence ID" value="RIE03674"/>
        <property type="gene ID" value="D3H35_10265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="149" mass="17157" checksum="EAD5FFE5DCA5CA59" modified="2018-12-05" version="1">MPLIRWKQPGDVKAIVRLVRTQLVPLSPWQHPRDGRLHGEIVKRLRQGSTLVAARSPRSVPFGFLHLIVQDRVLFIDMLAVDASQQGRHWGTYLLARAEEHGRKKGCADARLFVDDTNQSGLRFYERRGYRVLNHLKALLCFELTKPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYB0</accession>
    <name>A0A398CYB0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04787">
        <property type="protein sequence ID" value="RIE04787"/>
        <property type="gene ID" value="D3H35_04750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="226" mass="25383" checksum="6308B60851CB1B0B" modified="2018-12-05" version="1">MFKRLFVTDGVRMVPAVIRSYGFEDFEGLIDVQAKSFPPPYPSELWWNEKQLAEHVQRFPEGALCVEIGGAIVGSMTGLRLTMTDGDEHDWATVSDDGYIRNHEPDGDTLYVIDICVVPEYRKFGLGKWLMQSMYETVVHVGCRRLLGGGRMPGYSRAASELTPEQYVAQVTAGERTDPVLTFLLRCGRVPVGVVANYLDDEQSCGYAALMEWRNPFIDNDNEEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYH6</accession>
    <name>A0A398CYH6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04877">
        <property type="protein sequence ID" value="RIE04877"/>
        <property type="gene ID" value="D3H35_05285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="183" mass="21375" checksum="54D956BA3FA4A235" modified="2018-12-05" version="1">MSNINLLMVKYSRMESERILLRPVLLDDAEDMYEYTSDEETTRFIYDQHTDLNRTKNLIANYFMKEPIGKYAILLKESNKMIGTIEFRIHEHNKSGELGYTLNRHFWGRGYMTEAGNLILQLAFNTLDLERVFAEHDVRNSASGKVLSRLGMTYEGTRRRNHIVKGVLADSAHYSILKEEYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYS2</accession>
    <name>A0A398CYS2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_07275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04381">
        <property type="protein sequence ID" value="RIE04381"/>
        <property type="gene ID" value="D3H35_07275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="202" mass="22868" checksum="9366F261D4786C69" modified="2018-12-05" version="1">MLREARKNELKEKLFRTAVELFREKGYENVTVDEITSACGVAKGTFFNHFAKKDHVLLYLGRSQVERMEEIAIKLRQISDPKERVRSLFRSLLSRYENEGHLLRVVMAETVRSALLLSEEEKLAGELRKVLAELLEEAAEDGRLTKRFGLPVLASALCALYFQAMMMTASGDKEAQKLLDEQLDAVWDGFGGAERTDGGTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D028</accession>
    <name>A0A398D028_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sensor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_05840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000026">
        <property type="protein sequence ID" value="RIE04524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04524">
        <property type="protein sequence ID" value="RIE04524"/>
        <property type="gene ID" value="D3H35_05840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Sensor" evidence="2">
        <location>
            <begin position="3"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="221" mass="24133" checksum="6ADA0CB2959AD05C" modified="2018-12-05" version="1">MMVTSLPRGIAVFVIAIVGVCVGLPLAPFIIGLPILAATLKACERLMSGERKLAATWDRGEAHDPEHWEAQAAQSNDSERAATGWRSWIATLGRVQNYRGLLFGVAQLPATISAFTLAIVIPATFAGIALTPLAYLVSDRVFSFELFGDDWLLNRVFTNLTPENYSYIIGGIGLVLLLLTPYLIRRLGRMYAAWIRWIAGEEKAIDVSEPHGSAGLAESYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D089</accession>
    <name>A0A398D089_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04584">
        <property type="protein sequence ID" value="RIE04584"/>
        <property type="gene ID" value="D3H35_05545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="157" mass="18089" checksum="55B1655CEDF983FE" modified="2018-12-05" version="1">MDELERDRVMRLDNQICFAIYACSREINKLYYPLLKEINLTYTQYITMLALWEKDRVSVKELGTRLYLDSGTLTPLLKKLEQMGFVTRVRDKNDERIVLIELTEAGAALKESAAAIPEKLFCNSGLSSDEALAALRQTTDLLHKLQHQYDKEENSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1E3</accession>
    <name>A0A398D1E3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsS</name>
        <name evidence="8" type="ORF">D3H35_02260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE04994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04994">
        <property type="protein sequence ID" value="RIE04994"/>
        <property type="gene ID" value="D3H35_02260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="93" mass="10560" checksum="D75C222B6AAF7B39" modified="2018-12-05" version="1">MGRSLKKGPFVDGYLLKKVDELTASSKKTVIKTWSRRSTIFPQFVGHTFAVYDGRKHVPVYVTEDMVGHKLGEFAPTRTYKGHSDDDKKTGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBV8</accession>
    <name>A0A398CBV8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">DNA repair protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">radA</name>
        <name evidence="8" type="ORF">D3H35_29990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00263">
        <property type="protein sequence ID" value="RIE00263"/>
        <property type="gene ID" value="D3H35_29990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01121">
        <property type="entry name" value="Sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01498">
        <property type="entry name" value="RadA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
        <property type="entry name" value="DNA_repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00416">
        <property type="entry name" value="sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RECA_2" evidence="7">
        <location>
            <begin position="67"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Lon-protease-like" evidence="5">
        <location>
            <begin position="352"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RadA KNRFG motif" evidence="5">
        <location>
            <begin position="253"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="96"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="455" mass="49145" checksum="4CCF442703A2A11F" modified="2018-12-05" version="1">MAKVKVKFVCTECGTESPKWMGKCPGCNAWSTMVEETESVVKAPVGRTEANRTKEKARSIIDIESGREPRILTGLEELNRVLGGGLVPGSLLLVGGDPGIGKSTLLLQTASKLAAQGLKVLYVSGEESVRQTKLRADRLGALSDNLFVLCETNLDHVEEAIADVGPDFLVIDSIQTVYRPDVQSAPGSVAQVRECTAHFMRISKGNGVATVLVGHVTKEGAIAGPRLLEHMVDCVLYFEGERHHTYRLLRAVKNRFGSTNEIGIFDMTEDGLREVANPSELFLSERPTGVSGSTVVASMEGTRPVLVELQALVTPTHFPSPRRMTSGIDNQRVSLVVAVLEKRMGMFFQNQDSYVNVAGGIKLDEPATDLAAAVSLASSFKDLPTRPFDVVFGEVGLTGEVRAVSRAEQRVKEAHKLGFKRVILPETSMKGWQPPAGIQVIGVRTVAEALKAALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCE9</accession>
    <name>A0A398CCE9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_28745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00403">
        <property type="protein sequence ID" value="RIE00403"/>
        <property type="gene ID" value="D3H35_28745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="429"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="530" mass="61070" checksum="85C3CB8A3D26C5E3" modified="2018-12-05" version="1">MLSLLIVDDEKLLTESLKEDIDWAKLGIGSVYTAYNSHQAKQMFERASIDLMLCDIEMPQGNGLELLAWVKEHYPLTESVFMTCHAEFKLAQRAMQLGSFDYLLKPVPADELCQVVGKIANKIKKDNEIKQYSRIGQYWSRHQPLLAERFWMDIINHTIPSSLDLIQKEASERSITFDVNLRIVPLLIVIKRYHKTFSPRDEKIIEYALKNSSEELLGLQGNGLLFRLEDRKLLALIPIEQDAPELREALRERGSVLISSVADYFYCDVSIYVGNEVYSHELSEAVRWLTDWDKSNVAVTNKVFIWVDRNYRQELVDFPDMNLWSVMLKEGRGNDVMAQAETFLNSLIGSAHINAEILYRFHHNFLQMVFYVLKLNGIDAHLLFDNHASADLFQHAVRSVTDMIDWMKHTISKSLEYAGTVQQSESFMVRVNAYVTQNLENDGLTREDVASHVFLNPDYLDRLCKKETGCSVTEYIARMRMQLAKELLLKTNMPVGTIAAQVGYSNLAHFSRKFKRFEGTNPNAFRKLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCF6</accession>
    <name>A0A398CCF6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="3">2.7.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Flavin transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_25980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000045">
        <property type="protein sequence ID" value="RIE00866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00866">
        <property type="protein sequence ID" value="RIE00866"/>
        <property type="gene ID" value="D3H35_25980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE00866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="162" mass="17629" checksum="D0501777874CC3FC" modified="2018-12-05" version="1" fragment="single">NQSCRNRTKSSPDGARGWQLFPRAGLVRLRRGTRLDLGGIAKGWTVDRVSEGLIGRRIRAGQLNAGGDLRVWSEPGLPAWEIEAALPDGFASNAPSFRFALRNGAAATSSTLRRQWATPGGNRHHLIDPRSGLPAASDTVQCTVVERRQRSRNSCQDGAFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCQ5</accession>
    <name>A0A398CCQ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-layer homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00185">
        <property type="protein sequence ID" value="RIE00185"/>
        <property type="gene ID" value="D3H35_29540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="19"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="126" mass="13811" checksum="7EF4B4695EA12C64" modified="2018-12-05" version="1">MIARAIAYANPSLQASSGELRPTDSDHISSWAEDAVNQALELGIIKGDQTGNFKPKAEATRAEMVTLLSCMLQNNAYIVPSATSPFSEVGSNWLANEICAFADGTVRRQGNHEYVRTDHCKNERLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDI6</accession>
    <name>A0A398CDI6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc-ribbon domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_26590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00763">
        <property type="protein sequence ID" value="RIE00763"/>
        <property type="gene ID" value="D3H35_26590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DZANK-type" evidence="5">
        <location>
            <begin position="101"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="183" mass="19910" checksum="A22EF2740AAFDE4B" modified="2018-12-05" version="1">MSLFKKITESVSKGVSSATEKAQQTVEITRLYTQISGKRKEIDKLYAAIGELVYEAYEEDGGASSDARVDSICKDIAALRGEIDALDDRMKELRNEKDCVCARRVPYDTKFCPSCGHRFPEPPAPPVAASEPEAEEGEELPAVVAAEEAKEEAEPVICFSCGLSVEADARFCPACGHPADRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDS1</accession>
    <name>A0A398CDS1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type III pantothenate kinase</fullName>
            <ecNumber evidence="6">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaX</name>
        <name evidence="7" type="ORF">D3H35_23465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01336">
        <property type="protein sequence ID" value="RIE01336"/>
        <property type="gene ID" value="D3H35_23465"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="107"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="254" mass="27307" checksum="F4F1BC61F45A78B4" modified="2018-12-05" version="1">MILVVDVGNTNIVLGLYEGRTLTHHWRLSTNRSSTVDEYGVLIFNLFQIAGVRSSQIEGVILSCVVPPIMNTLEQLSVKYVGKQPLVVGPGIKTGLNIRYENPREVGADRIVNAVAGIEQYGTPLVVVDFGTATTFDYIDATGAYIGGAIVPGIGISAEALYQRAAKLPRIELARPRTVIGRNTVAAMQAGIIFGYAGQVDGIVRRIGKEFGVKPRVIATGGLAELISAESETIEKVDPLLTLEGLRIVYERNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDY1</accession>
    <name>A0A398CDY1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_27150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00645">
        <property type="protein sequence ID" value="RIE00645"/>
        <property type="gene ID" value="D3H35_27150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="396" mass="46231" checksum="5F0EC50993AAF971" modified="2018-12-05" version="1">MTTIPENMLNDLFENLVTQFVKQNIETIMRAEIKHMLEEQEEHQRNSRNGYYTRTLHTKYGHIEDLQVPRDRNGQFQTSVFEPYQRRDGWLEEAVIQMYKSGMGTRDVARFIESMFGSQYSPTTVSNITATVLEDIQIWLQRPLKKRYSVIYLDGLYVKLKRGTVSGEVVYFAMGIDEDGHRQILGFYIGGQESSNGWREVLKDLYKRGATDVLLGVFDGLTGLEAAFRETYPKADVQHCVVHKVRATFPKIRVQHRTEVIEDIKTVYTAEDKDLALAAFDTVYAKWGKLYPKEMELWKEQLPTLLTFYKFPSLIKEAIYTSNPIERMNKEIRKRLKPMNSLTNMDAAEKIVYLQAIDYNERNESRAIRGFADPEVKKRLTEMFEARYSDKITSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDZ2</accession>
    <name>A0A398CDZ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_26110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000047">
        <property type="protein sequence ID" value="RIE00850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00850">
        <property type="protein sequence ID" value="RIE00850"/>
        <property type="gene ID" value="D3H35_26110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="105" mass="11716" checksum="3E543A8DE84FC8A6" modified="2018-12-05" version="1">MMIDGAGKWKTFIHLTLPMIAPGITVNVLIGLANGLRIFDLPFALRRRAGRGERDAVGQNLPLRLLLDRAVPRAVGFVHFDADRARRYLLLHCAVQKIRKGTMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE11</accession>
    <name>A0A398CE11_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_26010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000045">
        <property type="protein sequence ID" value="RIE00870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00870">
        <property type="protein sequence ID" value="RIE00870"/>
        <property type="gene ID" value="D3H35_26010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="283" mass="32586" checksum="E23BDA48D16AC716" modified="2018-12-05" version="1">MTGEGLKPVQDKKRTILEAAIRCFSRKGFHATSIQEIAREIGMAKGSMYFYFNSKDELYLSVLEYYTDMLFRCMEELPEDRELSSRDKLRVLIERQFRFFREHLHFMRMLFLEPATGLNPQVQNLLMRTRARSAVWTLSHISAIYGNRAARYVTDAATMFEGMTGRYLEKLFFDDAELDEGRVSRFLINRIDHLMKGLLLTGEEPILPAPDMNALREKAGWPLEAEAQQRNGQLEELKRLVSAIPDSVPPAVRTEAASALERLESEWAKLVPDKLLAKGCLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE99</accession>
    <name>A0A398CE99_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01033">
        <property type="protein sequence ID" value="RIE01033"/>
        <property type="gene ID" value="D3H35_21520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039650">
        <property type="entry name" value="HdrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498">
        <property type="entry name" value="PTHR43498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="456" mass="50218" checksum="126AF70BE80E5637" modified="2018-12-05" version="1">MRRRLRRHRHWRRSGGVAAAVSSARNGAKTLLVEKRNGLGGLLTFGMLNFLDIKHGSDGKSINKGLFTEWHKLVGGDSAFDIELGKAAFYKMVADEKNLTLSLSTQLVSAQLGADGSTVEGVKLRNKNGEFSVSGKRFIDATIDADFAAMSGAPFFIGGEDIFDKSRLMSVTPVIHLKGIDWAKLKKASKASGWKFGKVDFNDTTAWGFAELFTLYKPVENNTRLRGLNLVRIRQSDGDHFYINALQIFGVNGLNENEKKTALEVGRRETDHIVEYLRKEMAGFEKATVASDATELYVRETRHLKALYQLPMSDVWRNQDHWDSIGHGGYPVDIQGTSLKDLGTVVSNPKTYAIPLRSLIPQKLTNMLVVGRAAGYSSIAAGSARVVPTGMTTGEAAGAAAAQSIKSNVNFHKFSADEKLVETLRTTLEKQGALVKHFNSKYPYQGNGTIMQLRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF82</accession>
    <name>A0A398CF82_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Urea ABC transporter permease subunit UrtC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">urtC</name>
        <name evidence="7" type="ORF">D3H35_23735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01383">
        <property type="protein sequence ID" value="RIE01383"/>
        <property type="gene ID" value="D3H35_23735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017778">
        <property type="entry name" value="ABC_transptr_urea_perm_UrtC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482:SF4">
        <property type="entry name" value="PTHR30482:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03408">
        <property type="entry name" value="urea_trans_UrtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="367" mass="40040" checksum="D057B00F9867A63E" modified="2018-12-05" version="1">MLQAIPFSRRTWMLIGYAAAAAVLFCAPLYLSDFRLNLLAKFLAFAIVAMGLDLIWGYTGILSLGHGVFFGLGAYAMAMHLKLTASGGRLPDFMDWSGLTQLPWFWEPFKYFGIAVAMGIVIPAALALFLGFFTFRNRIRGVYFTILTQALVIITVTLFIGQQAYTGGTNGLTGYTTLFGYSLKSSSTKTGLYLATVVILILAFLVCRYLVKSRFGKVLRAIRDGENRVRFLGFDPAMYQMAAFAISAGLAGLAGMLFVLHVGIISPSMMAIVPSIEMVLWVAIGGRGTVIGAVIGAVVMNSAKSGLSESYPDIWTFFLGALFIVVTVFLPGGIVGLFRSLSERMTRRRDSHEFIGHSVLRKSNRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGN9</accession>
    <name>A0A398CGN9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01625">
        <property type="protein sequence ID" value="RIE01625"/>
        <property type="gene ID" value="D3H35_25115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="131" mass="15045" checksum="DEC3758B3313B90A" modified="2018-12-05" version="1">MTGQRTEERRNKALTVTMTGKWSEARRNKAPTVTMTGKWSEARRNKAPTVTMTGQRTEERRNKAPTVTMTGQWSEARRNKALTVTMAGQWTGVRRNKVPTVTMTDEWSEERRNKALTVTMTGRRMYGISSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGR6</accession>
    <name>A0A398CGR6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="8">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gltX</name>
        <name evidence="12" type="ORF">D3H35_30035</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00269">
        <property type="protein sequence ID" value="RIE00269"/>
        <property type="gene ID" value="D3H35_30035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="10">
        <location>
            <begin position="4"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="11">
        <location>
            <begin position="358"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="252"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE00269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="490" mass="55784" checksum="9DEE5694813E603E" modified="2018-12-05" version="1">MSTKVRVRYAPSPTGHLHIGNARTAIFNYLFARRHGGDFIIRIEDTDVKRNVAGGEENQLTYLKWLGVDWDESIDRHGEYGPYRQTERLDIYAAYTKELLDKGLAYRCYCTEEELEREREEQLARGETPSYSGKHRQLTAEQEAAYVAEGRVPSVRFRVPDDRTYTFDDLVKGEISFKSEDFGDFVIVKKDGIPTYNYAVAVDDHTMAISHVLRGEDHITNTPRQLMIYEAFGWTPPQFGHMTLIVNENRKKLSKRDESIVQFIEQYDELGYLPEALFNFITLLGWSPEGEEEIFSRERFIEIFDSNRLSKSPAVFDTAKLNWLNQHYLKAADAERVIELCLVHLKKAERLPENPSEEQLVWAAGLVTLFRDHLRFGAEIVPLSDMFFRNEAPELDEEAGAVLAEPSVPTVLGAFRRSVEAAGIEGFTVDGIKAMIKGVQGETGVKGKGLFMPIRVALTGQTHGPDLNGTIWLLGRDKVLKRLEETLQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGV4</accession>
    <name>A0A398CGV4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000059">
        <property type="protein sequence ID" value="RIE00309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00309">
        <property type="protein sequence ID" value="RIE00309"/>
        <property type="gene ID" value="D3H35_29260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="161" mass="18029" checksum="766806D010FC3EA2" modified="2018-12-05" version="1">MRQLRLRYTKIIGYYDTIPNDFLATYASPFRDYKEITYVGGANGLPPKVMSRIRAFPTDGHNERALHTTLTLTLLQAIPLLFASTALQKAQFCGTSTSRIPSGWAITEISDHIFPEKDRCGSCELIKELQVSGMSSPFAPTGAEGFSLFSFRPYRNLILNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH29</accession>
    <name>A0A398CH29_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_23065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01272">
        <property type="protein sequence ID" value="RIE01272"/>
        <property type="gene ID" value="D3H35_23065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="229" mass="25190" checksum="05A7D4A7BE0F171B" modified="2018-12-05" version="1">MNVIQVDGLNKTYGKGSTQVSALQNVSFSIKQGEFVAVIGASGSGKSTLLHMLGGLDKPSGGHVHIDGEDLYGLKEKERAVFRRRKIGFIFQSYNLIPVLNVEENIQLPLLLDHRQPDKSYINDLIRTLGLEERRKHLPSELSGGQQQRVAIGRALAYRPAIVLADEPTGNLDSASGREVLELLKLAVRQFHQTVIIISHDMNIAAEADRVLRIQDGRLVSDTYGGKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH70</accession>
    <name>A0A398CH70_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_28950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00439">
        <property type="protein sequence ID" value="RIE00439"/>
        <property type="gene ID" value="D3H35_28950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="256" mass="28942" checksum="57857CE8DA21D563" modified="2018-12-05" version="1">MSTALLQVNNVSKSFRSAGKAAPVLERLQLTVNRGEIVSVIGPSGCGKSTLLKIVAGLDVDFEGEVLLEGTRITRASREKGFIFQEHRLFPWLTVEGNIAADLSLRDPDVRLRVNELIELVKLKGFEKAYPRQLSGGMSQRVAIARALLRNPKVLLLDEPFGALDAFTRSHLQEALLDIWREHRTTMLFVTHDIDEALFLSNRVVIMDSRPGRIKQIVPVELLIPRDRSSVAFQHLRTHVLRTLEHKEPEEDDWEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHB2</accession>
    <name>A0A398CHB2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding protein S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_23615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01362">
        <property type="protein sequence ID" value="RIE01362"/>
        <property type="gene ID" value="D3H35_23615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="144" mass="15736" checksum="C26ABD0493FF7620" modified="2018-12-05" version="1">MAIEVGTKLEGKVTGITHFGAFVDLSGGVTGLVHISEIADSYVKDVNEHLKIADVVTVKVINVDKDGKIGLSIRQAVDKPPEQQQQQQQNRGPRDRGGRPFKPGPGRATFEDKVSRFLKDSEERISNLKKSTESKRGGRGGRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHB8</accession>
    <name>A0A398CHB8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">QacE family quaternary ammonium compound efflux SMR transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_13880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01870">
        <property type="protein sequence ID" value="RIE01870"/>
        <property type="gene ID" value="D3H35_13880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="104" mass="11177" checksum="5672AD2309ED26CF" modified="2018-12-05" version="1">MAWVYLIIAGMLEVVGVIGIKRTAVKNNWTNNLLLIGGFVISFQFLLQALDEIALSTAYAVWTGIGSVGAAVVGMLFFKESKSRLRMLCIAGVIGCVVGLKLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHH7</accession>
    <name>A0A398CHH7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4446 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01442">
        <property type="protein sequence ID" value="RIE01442"/>
        <property type="gene ID" value="D3H35_24065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027981">
        <property type="entry name" value="DUF4446"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14584">
        <property type="entry name" value="DUF4446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="163" mass="17820" checksum="867D9E1E6985163F" modified="2018-12-05" version="1">MNGWSDQIAIAVAAGEGVVLVVLLVWIMALTSKLGKLNRAHQKLMGETGVANLEDAMGALHDRMSQVGARQSEQQERLDHQERRLTTMKGRIGVHRFNAFSDSGSDLSFSVAFVNDEQDGVVITGIHGREQTFLYAKPIDKGQSAYMLTPEEKIAISQASHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI70</accession>
    <name>A0A398CI70_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01722">
        <property type="protein sequence ID" value="RIE01722"/>
        <property type="gene ID" value="D3H35_13005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="128" mass="14775" checksum="AAC4A9BFB9F8E50B" modified="2018-12-05" version="1">MYTISEVAKSLGVTTHTLRYYEKEEIIAPKRNANGERMYDETHLAWLQFVMRLKQTQMPISQIRKYAQLYLEGEHTAQARLNLLEDHRSSLQNQISNLATTEKMLKDKIAGYKDLISRAATSNGARKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIE1</accession>
    <name>A0A398CIE1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type 1 glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02135">
        <property type="protein sequence ID" value="RIE02135"/>
        <property type="gene ID" value="D3H35_15375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="PTHR42695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="234" mass="26498" checksum="0BCC6DBA1DE030CB" modified="2018-12-05" version="1">MNIKVFKHFSFDDTGAFERWASHNGHTLDILDPAEGVRAEWLDGLDLLIILGGPMSVYEEELYPWLIEEKRFVGQAIELEKKILGICLGAQMLADVLGSKVYRHPCKEIGWHPINRSEDRHPWLAGLPERFHSFQWHGDTFELPTGATRLAGSDACSQQAFAYGDRVLGLQFHLETSPACMEVMLDRWADQLTDEPCIQSAERIRAETARSDASLRMLHGILDRIALQSESPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIG5</accession>
    <name>A0A398CIG5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_17740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02533">
        <property type="protein sequence ID" value="RIE02533"/>
        <property type="gene ID" value="D3H35_17740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="510"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="616" mass="67764" checksum="D542E31B7AD7723D" modified="2018-12-05" version="1">MLAFAVEGLIISGAALAIGPFLGMALAQALGTSNGFLEFVQRSSMNVHLNSKAYAYGGIAAAVSFGMMLIPVLLATRTSIVGHKQQLARMTKTPLWHKMFLDVLLLGVSIYGLYEFRSRLKDVTSLGLNADDLQIGSLQFVIPALFIVGSGLLLLRLYPYLLSLIYYIGRKWWAPAWYATLIQVGRSIAQYQFLMVFLIITIATGVFSAGAARTINNNIEERIRYAAGADISLNSVWQSDATPISASSGPTMAFAQTKTTETASAIKIIHYLEPPFDPYRNLPGVEEAAKVFVNDSATFTAGESKGFAKLIGIDTYDFGMTSWFKDYLNGYPLYEYMNLMAADPRAVLISRTLADTMKVKQGDTILVGWNEVNEKPFVVYGIVDYFPTFNPNPPLGSVSAADPNAKDGKPMLIVGHLSRIQMQLALEPYQVWLKMKPGFSTTQLYEGIEKSKLSVIDIVNSKENLVLAKRDPFLMALNGILTLGFLISIIITFFGFLLYWMLSLKGRTLQNGIMRAIGLSLRQLLGMLALEQLLTSGVAIMIGAIVGNVTGRLFVPNFQIAFNPSTLVPPFRVVFAQIDFVRLYIIVGIMLLLGLGILGYMLSRIRIHQALKLGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIH3</accession>
    <name>A0A398CIH3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_14700</name>
        <name evidence="8" type="ORF">D3H35_15650</name>
        <name evidence="9" type="ORF">D3H35_16815</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02012">
        <property type="protein sequence ID" value="RIE02012"/>
        <property type="gene ID" value="D3H35_14700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02175">
        <property type="protein sequence ID" value="RIE02175"/>
        <property type="gene ID" value="D3H35_15650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02376">
        <property type="protein sequence ID" value="RIE02376"/>
        <property type="gene ID" value="D3H35_16815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="396" mass="46231" checksum="4621CEA4ECF1234A" modified="2018-12-05" version="1">MTTIPENMLNDLFENLVTQFVKQNIETIMRAEIKHMLEEQEEHQRNSRNGYYTRTLHTKYGHIEDLQVPRDRNGQFQTSVFEPYQRRDGWLEEAVIQMYKSGMGTRDVARFIESMFGSQYSPTTVSNITATVLEDIQIWLQRPLKKRYSVIYLDGLYVKLKRGTVSGEVVYFAMGIDEDGHRQILGFYIGGQESSNGWREVLKDLYKRGATDVLLGVFDGLTGLEVAFRETYPKADVQHCVVHKVRATFPKIRVQHRTEVIEDIKTVYTAEDKDLALAAFDTVYAKWGKLYPKEMELWKEQLPTLLTFYKFPSLIKEAIYTSNPIERMNKEIRKRLKPMNSLTNMDAAEKIVYLQAIDYNERNESRAIRGFADPEVKKKLTEMFEARYSDKITSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIJ1</accession>
    <name>A0A398CIJ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage tail protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00668">
        <property type="protein sequence ID" value="RIE00668"/>
        <property type="gene ID" value="D3H35_27285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011083">
        <property type="entry name" value="Phage_tail_collar_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037053">
        <property type="entry name" value="Phage_tail_collar_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07484">
        <property type="entry name" value="Collar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Collar" evidence="1">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="167" mass="17430" checksum="8EF8F90349265E1B" modified="2018-12-05" version="1">MSDQYVGEIRIFSGNYAPQGWAMCNGQLLPVSGNELLFAVIGAKYGGDGKTTFALPDLRGRLPIHMSSAYAFASKGGTETVTLDLAALPAHTHVVNANSLPGTSDSPSNAFWAGSTLNQYSTAGSNGTMDSLTVSSAGGNQAHNNVMPYSVLTFIIALQGIYPQHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIL0</accession>
    <name>A0A398CIL0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent helicase HrpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hrpB</name>
        <name evidence="4" type="ORF">D3H35_17975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02573">
        <property type="protein sequence ID" value="RIE02573"/>
        <property type="gene ID" value="D3H35_17975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010225">
        <property type="entry name" value="HrpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013689">
        <property type="entry name" value="RNA_helicase_ATP-dep_HrpB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08482">
        <property type="entry name" value="HrpB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005496">
        <property type="entry name" value="ATP_hel_hrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01970">
        <property type="entry name" value="DEAH_box_HrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="14"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="205"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="840" mass="92414" checksum="7D468B43860542F9" modified="2018-12-05" version="1">MSSLPIEQALPSLKEALERHNGAVLVAAPGAGKTTRVPLALMDELWLGGRKMIMLEPRRLAARSAANYMARQLGEPVGRTVGYRVRMDSKVGPETRIEVVTEGVLTRMLQEDQALEGVGLVIFDEYHERSLQADLGLALSLQTQALLRDDLRLLIMSATLEAEPVARLLGDAPVVVSEGRSFPVDTFYRPVPKKWQDRAEGIARVIREAMARHDGDALVFVPGMSEIRAVERIVRGGSFGLPSGTEVHLLHGSLPPEAQDRAIAPPLTGIRKIVLSTSVAETSLTVEGVTIVVDSGLARVSRFSPRTGMSRLETVPVSSASADQRRGRAGRVKPGVCYRMWSEEEQGHLPSRSAPEITEADLAPLLLELAVWGVNDPAELEWLDAPPKPAVQQARELLVRLGALASDGTVTGHGRRMAEASVHPRLAHMILAAEPLGLGGLACELAALLGERDLFAGGGGRQASSDMRLRVEALRGIPSSGTVVDDATRKRISQEIGRLRRELGIGGDGKVRVSPYAADTDACGLLLAFAYPDRIARRRESGAYLFSGGRGAELREGQALAREEWLVAADVDDVGADSRIRLAAPVQWAELAEHCGEQIAEEKIVFWDRESQSVRARSRRMFGALLLEETPLQNPPPELVRDKLLEAIRQEGLDMLPWSKAARQLQERIVFMARHDTSWPDASDETLAESLEHWLAPYVDKMKSRGDLQRLHLKDILEAMLSWNKKRELDEEAPTHWNVPSGSRIPIDYSDPEAPALAVRLQELFGLPESPRIGGGRVALTLHLLSPAQRPVQVTRDLASFWRNTYFEVRKDLKGRYPKHYWPDNPLEAQATRRAKPPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIN3</accession>
    <name>A0A398CIN3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">High-affinity heme uptake system protein IsdE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Iron-regulated surface determinant protein E</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Staphylococcal iron-regulated protein F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">isdE</name>
        <name evidence="10" type="ORF">D3H35_16020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02240">
        <property type="protein sequence ID" value="RIE02240"/>
        <property type="gene ID" value="D3H35_16020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015886">
        <property type="term" value="P:heme transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019957">
        <property type="entry name" value="ABC_transptr_haem-bd_IsdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03659">
        <property type="entry name" value="IsdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017383674" description="High-affinity heme uptake system protein IsdE" evidence="8">
        <location>
            <begin position="26"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="9">
        <location>
            <begin position="55"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE02240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="308" mass="33185" checksum="9B77DA14A8A8D6C8" modified="2018-12-05" version="1">MVKKLKGPAALVAALLFCLTGCGGAQSGSNADAPTASAPTAKATEAAAEGTKEHRIVSTTVALTQIMDRLEIDLVGVPKSVKTLPKRYDGVTKVGNPMSPDMELVKSLKPTEVLSVTTLQYDLEPVFVNARIDATFVDLTSLDSMKTAIAKLGEKYDRQEKAAEIIGEYDKVLSDIREASAGKKAPTVLILLGVPGSYLVATEHSYIGDLVHLLGGVNIVQGEKVEFLASNTEYLQQANPDVILRAAHGMPEEVVKMFDEEFKKNDIWKHFSAVQTGRVFDLDEKLFGTTGNLAVDEALHALLPMLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIZ3</accession>
    <name>A0A398CIZ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02703">
        <property type="protein sequence ID" value="RIE02703"/>
        <property type="gene ID" value="D3H35_18785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="120" mass="13481" checksum="5202DFFBDD87EA26" modified="2018-12-05" version="1">MIRPYSCSISPNRARDPFSRLVEALIMEITFEALREAGVRLAQQVARHVSTSRQIRGYISTANCRDDILPLSIIANTFCLRSCPRVKRLPESAGFVSVVQIGERRKTSFSSRTSSGYSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ03</accession>
    <name>A0A398CJ03_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO</fullName>
            <ecNumber evidence="10">2.1.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Folate-dependent tRNA (uracil-5-)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Folate-dependent tRNA(M-5-U54)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">trmFO</name>
        <name evidence="12" type="ORF">D3H35_11330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:16873"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.74"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:62372"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.74"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MnmG family. TrmFO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.74" evidence="10"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03276">
        <property type="protein sequence ID" value="RIE03276"/>
        <property type="gene ID" value="D3H35_11330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030698">
        <property type="term" value="F:5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047151">
        <property type="term" value="F:methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01037">
        <property type="entry name" value="TrmFO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004417">
        <property type="entry name" value="TrmFO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF2">
        <property type="entry name" value="PTHR11806:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00137">
        <property type="entry name" value="gid_trmFO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 10 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0520">NAD</keyword>
    <keyword evidence="8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GIDA" evidence="11">
        <location>
            <begin position="7"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE03276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="438" mass="48272" checksum="4EAF87FFAF5058EA" modified="2018-12-05" version="1">MTEIRSVTVIGAGLAGSEAAWQIASQGVPVTLYEMRPVRRTPAHHTDRFAELVCSNSLRANGLTNAVGVLKEEMRRLGSLILSSADKHAVPAGGALAVDREGFSGEVTSHLREHPLVTVVNEELPVIPDDGIVVVATGPLTSPDLSSQIKELLGEEYFYFYDAAAPIIEKDSIDLEKVFLASRYDKGEAAYLNCPMNPEQFEAFYEALITAETAEIKEFEKEMYFEGCMPIEVMAKRGKQTMLFGPMKPVGLDDPKTGRWPHAVVQLRQDNAAGTLYNLVGFQTHLKWGEQKRVFSLIPGLENAEFVRYGVMHRNTFINSPKLLKPTYQFAKRETLFFAGQMTGVEGYVESAASGLLAGLNAGRLARGLEPVVLPAHTTLGSMANYITTADFRHFQPMNANFGLFPPMENRIRGKKERNEAIAARALEEIDTFVKSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJQ1</accession>
    <name>A0A398CJQ1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pur operon repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_23815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01399">
        <property type="protein sequence ID" value="RIE01399"/>
        <property type="gene ID" value="D3H35_23815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045982">
        <property type="term" value="P:negative regulation of purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015265">
        <property type="entry name" value="PuR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010078">
        <property type="entry name" value="PurR_Bsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43864:SF2">
        <property type="entry name" value="PTHR43864:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09182">
        <property type="entry name" value="PuR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01743">
        <property type="entry name" value="purR_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="PuR_N" evidence="6">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="113"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="276" mass="30633" checksum="000DD899E5A53149" modified="2018-12-05" version="1">MKKLKRSARLVEMTQYLLSRPHTLISLTAFAERYQSAKSSISEDLAIIKEVFEDEGVGELHTLAGAAGGVRFVPKVRKDIALGKIVDICRELEQPDRLLPGGYLYMTDLLGVPGMMQEVGRMFASAFANRNIDVIMTVETKGIPLAHATAHYLNLPVVIVRRDHKVTEGSAVSINYVSGSTKRIQTMSLARRALKEESRVLIIDDFMKAGGTIQGMVDLLHEFRALVAGVGVFVESGEIESDERLLHDYVSLARLTEVDLKSRHITVQPGNFFHNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJU5</accession>
    <name>A0A398CJU5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02580">
        <property type="protein sequence ID" value="RIE02580"/>
        <property type="gene ID" value="D3H35_18015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="284" mass="30535" checksum="F84CD27006E0BFDE" modified="2018-12-05" version="1">MTRAERTFVTRCSLAVRPIDSWTGRPPGGSSLTVRLLETGRKPVQTSDGSYAFLDFADSACTLVIGSPTYLEVRRTLDLTRLDPRMPTVTVSMLPNRAYPPPAASTGLVFTVCNPAGDAVPGAEVSAYIDDEAAIRGRVAEEKTERGAQAVLVAPGGVRLSSGDSFVLRERTGTAEEWGFVDGIDGSGNRLLLGGRYPAYGAGVRSCSGRKNPQRRERTRYRSFSRTASADLSGSRGNLFGRQALYGRMDDGSGQCNEAPSRPTVSIIHCALRRLDDGPVFLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJX8</accession>
    <name>A0A398CJX8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_29555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00187">
        <property type="protein sequence ID" value="RIE00187"/>
        <property type="gene ID" value="D3H35_29555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017235065" evidence="2">
        <location>
            <begin position="46"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="452" mass="49722" checksum="7040E27EAA08D251" modified="2018-12-05" version="1">MIAATNLINKGITKLKKTGLIAFALLMAFTLALTGCASSNNSSKATDSGTTAPSGATTKPSGETGKKEKIKAVYWTWLSAQQAAVDKYNSMQDEVEIELVQMSHTDIQQKLLIALASGTGAPDMFQQPQRTFSNISRTGKLMDVTSYLEGSLDKFSPAVTSLLSYDGKYYGMAPDVSPGVLWYRKDVFEENGIGEIKTWNEFLAAGEKLKKKGLYIMPIFNPAGTWGANEVAMFLQSRGGNFFTEDGKVIKNNAELEYVLNWFNDVYKSGISEGIKFFTPEFWGEFKAGKIVAWPMNIAEGSNLKTNAPELAGKWDVMPFPKWDDKDEQLTGYWGGTAIGIPDMSPAKEAVVKYAQWLSTTTEGQQAMYSSWGSVPSNLEAIKDPVFTKGDDYFSGSSPISKINDVKPFYYFDFSKVEAIVGEQIDLMFTGKQDAAATARNIENWIAKDTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK08</accession>
    <name>A0A398CK08_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidoglycan endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_18620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02675">
        <property type="protein sequence ID" value="RIE02675"/>
        <property type="gene ID" value="D3H35_18620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017318656" evidence="3">
        <location>
            <begin position="29"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="100"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="245" mass="26057" checksum="3B300DBA9DDE349F" modified="2018-12-05" version="1">MRKQAGWLLAAGIMMLGSSAWLAPQASAAAPIAGKQTVQAKSWPQNPEWNWSGSGNNNESDQNSGSGSEGGSDSGVVSEGGSDSGSGNSGSSGEQTGGSSTAIEKIIKAGMDYWGTPYEFGSDRDTDKTFDCSDFVKWIFKHAADVTLPSDSRKQGAFVKEHGNAQTDWHKLKRGDLMFFMSYEGSNASDYSKASKSSERITHVGVYLGDGKILHTYSKASGGVQTTDIEGTTWEYRFLFGGSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK81</accession>
    <name>A0A398CK81_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2500 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03716">
        <property type="protein sequence ID" value="RIE03716"/>
        <property type="gene ID" value="D3H35_10495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019635">
        <property type="entry name" value="DUF2500"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10694">
        <property type="entry name" value="DUF2500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="127" mass="13909" checksum="2B5687B565110374" modified="2018-12-05" version="1">MNPYAEPDGFFGFMSELPLFFKIFGGIVVALVAGTFLYVIVKGLSIWSSNNAASIQVRKAKVVDKRTEVWGGSGDSSANTNYYVTFEFEDGTRVELPVATKHYGLIAAGDQGTLTHQGTRFKGFDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKB0</accession>
    <name>A0A398CKB0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative baseplate assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_18080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02592">
        <property type="protein sequence ID" value="RIE02592"/>
        <property type="gene ID" value="D3H35_18080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006949">
        <property type="entry name" value="Baseplate_J-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011749">
        <property type="entry name" value="CHP02243"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04865">
        <property type="entry name" value="Baseplate_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02243">
        <property type="entry name" value="TIGR02243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Baseplate_J" evidence="2">
        <location>
            <begin position="183"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="462" mass="50717" checksum="8DF41BAD233FC433" modified="2018-12-05" version="1">MLNTVNATQQDTLSEQESYDSPGTPSFSLVADSWLARYGQLRVQVLGQDGRWREWRETASWDGAGPDDRLYRVERPDADGPQTVRFGDGVRGAIPREGTGTVRIIRHTMEFASVAMIGRSNGLPLQTIRLYDLPCRRADGMRLQVGAFDESAGELVWEDWEAVADFDRSGPLDRHFVFDTESGELRFGNDESGAIPAAYEYSNVVLTTCVVGGGERGNIKPDLLTEWVSPVQRALGISVTNTAYASGGEEGESLGECLERAQAEWQKPYCAVTNDDYRAIAMETPGLKVARAHVIPGFAPGKPDSPGAVTVVVVPQGLDETPQPSVGFLGTVARHLDERRLLTTEVHVIAPEYVRVTVHATVVVEPHFMEEARRIVAELNRLLTPLGRSGSSEGWPFGRTVHKGDIFGVISRMNGVAYVQDLWLDSEGRYVRKNAGGDILLPPNGLAYSGEHRIELISRTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKB8</accession>
    <name>A0A398CKB8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2019 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03746">
        <property type="protein sequence ID" value="RIE03746"/>
        <property type="gene ID" value="D3H35_09315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018568">
        <property type="entry name" value="DUF2019"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09450">
        <property type="entry name" value="DUF2019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2019" evidence="1">
        <location>
            <begin position="16"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="122" mass="13731" checksum="000D0090BB5D3797" modified="2018-12-05" version="1">MRVIGADTLELVQKQINDFIDAAIQHGECTEIGNSKLGNKFYKKIMMSSEVIKSSEKGKEVFLELMKHPNISVRLWSASFAYQNNPIEAEQVLQDIIGIKKSLVSFTAEITLNELKSGRLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKD9</accession>
    <name>A0A398CKD9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfbG</name>
        <name evidence="2" type="ORF">D3H35_19525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.45" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02825">
        <property type="protein sequence ID" value="RIE02825"/>
        <property type="gene ID" value="D3H35_19525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047733">
        <property type="term" value="F:CDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05252">
        <property type="entry name" value="CDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013445">
        <property type="entry name" value="CDP_4_6_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02622">
        <property type="entry name" value="CDP_4_6_dhtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="15"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="372" mass="41595" checksum="83DB4AD231C2C727" modified="2018-12-05" version="1">MSVNPSFWRGKKVFMTGHTGFKGAWLAVWLRRMGADVTGYALRPPAASNLFELCNLDELVPTVFGDVRDSQSLEKAVGQADPDVVFHLAARPLVRASYDKPRETFEVNVVGTVNMLEALRLAAGTRAVSRPRAFVNVTTDKVYDNRDWAWGYRENDALGGYDPYSGSKACSELVTASYRSSFWNPSSYSEHLTSLATARAGNVIGGGDWAADRLVPDAVRALQSGKAMKVRYPMAIRPWQHVLEPLSGYLMLAERLVEDGPRFGESWNFGPDSSDVRTVKEVLGLMGDCIGSHSFYELEPSNANPHEAGLLKLDCSKANRQLRWTSKWSLDTTVRKVLDWYDAYERQEVMLAFCERQIDEYLNGWRDPVCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKR4</accession>
    <name>A0A398CKR4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable GTP-binding protein EngB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">engB</name>
        <name evidence="10" type="ORF">D3H35_07965</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for normal cell division and for the maintenance of normal septation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03896">
        <property type="protein sequence ID" value="RIE03896"/>
        <property type="gene ID" value="D3H35_07965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0717">Septation</keyword>
    <feature type="domain" description="EngB-type G" evidence="9">
        <location>
            <begin position="22"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="214" mass="24050" checksum="0AE3FF91E474A750" modified="2018-12-05" version="1">MKIKTSEFVISAVGEDQCPVDGLPEICLAGRSNVGKSSLINKLLLRRNLARTSAQPGKTQTLNYYRINGEMYFVDFPGYGYAKVSKSQRQSWGKMVERFLRERKPLRLVLQLVDLRHPPSAEDCAMYEWLAHYGFPMCVVATKADKISKSQWPKHAKIIRTGLRMPGHVPLVLFSSETGMGRDELWSIIAQACGIETESPSEPAKVMQETEDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL83</accession>
    <name>A0A398CL83_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000051">
        <property type="protein sequence ID" value="RIE00607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00607">
        <property type="protein sequence ID" value="RIE00607"/>
        <property type="gene ID" value="D3H35_27495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="62" mass="6540" checksum="72A8450B3AEA3A9D" modified="2018-12-05" version="1">MLRALDLIPDLLQHVGIDSQVDIEIEEAAAVWPAPKLDDLKLGKETPVCSSVTSVSLGGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLD2</accession>
    <name>A0A398CLD2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">M6 family metalloprotease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_12525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03473">
        <property type="protein sequence ID" value="RIE03473"/>
        <property type="gene ID" value="D3H35_12525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005085">
        <property type="entry name" value="CBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM_fam20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03423">
        <property type="entry name" value="CBM_25"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05547">
        <property type="entry name" value="Peptidase_M6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01066">
        <property type="entry name" value="CBM_25"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="561"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="746"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="931"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="3">
        <location>
            <begin position="1107"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1214" mass="129418" checksum="C81EB36ED072DF68" modified="2018-12-05" version="1">MLFWKQQMRKRLHTKNRGVDERMKRHYRLLYLFSFLLLAALAIGGLASASPARTDLQTFTQPSGVTFQAKLQGDENLNWATTPTGDILIKDNQKYWNYAEIGSNAPKASGRKYGIDVRPSSAIDQADLQQLNELHPEAFEAPAPAPGISLKSSESQSGGSPSINGISATGTQRILVLLVQFSNVSILNSDADWSNQFFGTTGKTVRTYYNDISGGNLTFLPATESSGTANDGVVKVTLSYAHANKETSDTGRTITKDALTAANPYIDYASYDTNGDGYIANDELQIVTILAGKEESYGDTGTNPSVWGHKTFLYGSLSPTLDGKVLCSYIVDAGYTQQGEMHGSHMATIGILAHELGHMLGLPDLYDTDGSSYGIGTLSLMAHGSWGSLPGEFSGTTPSQMDAWSKVKLGFVQPTVVKPSTSTAYTLKSLLAGGYNVLKLPTAVPEQYFLVENRQLEGYDASISAASGGIAIWQIDDSRSSNSDDNRRWVELKIGQFFDPLYHSGSATQFGPTTTPNSDRFRELNGYAKKYTGVRVNVNSSSSQSMVVNVYGDYDNTAPAAPSGLTSTFQTASSVALSWNPSTQPDFDHYVIYQDGYYMDAQETTTAKYVMLNTSTSYTFSVKEVDLSGNESPASAITVSTTSGPDQIIVYYKRGLSNPILHYNSYYKDAIWYSTTMLQSEIAGYSKAIIPVGDIPNGIQAKITDGLGNWDDRGGSNYYFTSGINVLDNGVIYTELPETDTQAPTAPTNLASTGKTDTTVGLSWTASTDNVGVTGYDIYRGTTKVGTTASTSYTVTGLSPSTAYTFTVKAKDAAANESAASGAITVTTNAATGNVVTIYYKQGFTAPYIHYKLNGTWTSLPGVAIPAAEVTGYNKITINIGTATQLEACFNNGSGTWDSNNGANYFFPVGTSTYNAGTIVSGAPDTEPPTAPTNLASTGKTDTTVSLSWTASTDNVGVTSYEIYQGSSLLGTSTTTSYTATGLTANTAYTFTVKAKDAKNNVSSASNAITVTTNPSTGNTATIYYKRGYATPYIHYQPDSGSWTTAPGVAMTSSEFAGYSKITIQLGSASALSVAFNDGNGNWDNNGGSNYHFYAGTSTFVNGTITGGLPQADSLTIVVTAPSNTPSNADLYLASSLNGWSTNDSAYKLTKNTNGTYSITLYIASGTSFDFKVTKGSWAGVEANSNGTDISNRTFTTSGGAQTLNITVQRWKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLR3</accession>
    <name>A0A398CLR3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_15535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02159">
        <property type="protein sequence ID" value="RIE02159"/>
        <property type="gene ID" value="D3H35_15535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="184"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="383" mass="42148" checksum="29CB6C958D6B2F7C" modified="2018-12-05" version="1">MNATIRLKGFNFFYFSMFALFISFLPVYMAKVGVSKTHLGFILGLGSVVCIVSQPFWGVISDKYRTVRKVLLLLILLSVLSGSFLFQSVHLWSLLPAVLLMNLFFLPTDPLVESLNFRTTQAQKVSYGSVRMFGALGYAITSLLAGGVLAQWGMDSLAWIFAGAGLLALLLAFGLADVETSAKPVLVRHLRSFLLKRDTIALLVVVFAVAIPHKMNDIFIGLYMDELGGSMRLTGMSWFVMTIMETIMFAASSRLIRPGREGLLMTIAAGLYAVRFLLSSFVTDPYELVGLQIFQGFTFVLFYVGALQYLYSIVPEEWKSTGQTMVTVLFFGVSGIIGSGIGGWLLDELGGAWLYRIMAALAVAGFVLCMALLGRRRTSQEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLT8</accession>
    <name>A0A398CLT8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000051">
        <property type="protein sequence ID" value="RIE00611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00611">
        <property type="protein sequence ID" value="RIE00611"/>
        <property type="gene ID" value="D3H35_27515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="76" mass="8427" checksum="05AEAC9526879C40" modified="2018-12-05" version="1">MERHLNELHQIEVDQIGHELDTLVRATSPSMIVFRSLTVVGTSSNVPSLKRMFAEYVTCPPVSVMTGNVQSKKLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLV0</accession>
    <name>A0A398CLV0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04326">
        <property type="protein sequence ID" value="RIE04326"/>
        <property type="gene ID" value="D3H35_06915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="152" mass="17901" checksum="2D8F5C0513B910A3" modified="2018-12-05" version="1">MNIRKATVEDIAALILMRWEFTLEHQPEVSDNFELFATECRAFLEQEISGERWHIWVAEVDGVIASHVYIQLIDKVPRPGRITYPFAYMTNVYTDPDYRSRGIGSRLLKTIQEWAAANKIEFIIVWPSEESREFYARNRYTLCNDPMELHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM12</accession>
    <name>A0A398CM12_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prepilin peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_25320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00897">
        <property type="protein sequence ID" value="RIE00897"/>
        <property type="gene ID" value="D3H35_25320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="3">
        <location>
            <begin position="13"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="163" mass="17300" checksum="CFED53216D41126F" modified="2018-12-05" version="1">MSRMNEIEWGAAAMLLFAAAWTDLTTMRIPNALNAGFAVAGLLYQGIVDGSVGLGYAIFGALAGMLPLGLLLLLKGMGGGDVKWFGAFGIWAGAGITLQLVVWSILIAGVIAVAVALMKAPLIKRMARKIPWPWGEHPTAVARGVKFRSCWQLCRLSGSLDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM42</accession>
    <name>A0A398CM42_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03713">
        <property type="protein sequence ID" value="RIE03713"/>
        <property type="gene ID" value="D3H35_10480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="65" mass="7445" checksum="7145F902C67C5A9C" modified="2018-12-05" version="1">MNVFWMLPDTTVHKQEVADIEQLMFLMRMVTTTSIKGRAYRISDTELLVDSDRISIVVTLVNAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CME6</accession>
    <name>A0A398CME6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rho</name>
        <name evidence="12" type="ORF">D3H35_21650</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01047">
        <property type="protein sequence ID" value="RIE01047"/>
        <property type="gene ID" value="D3H35_21650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01128">
        <property type="entry name" value="rho_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041703">
        <property type="entry name" value="Rho_factor_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="11">
        <location>
            <begin position="51"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="167"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="179"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE01047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="438" mass="49432" checksum="8C7CC0C9EBB6CFCB" modified="2018-12-05" version="1">MSDYQMSDLEEKKLTELYKLAKEHQIAAYGQMKKKELILAILRAQAERSGFMFMEGVLDVLPDGYGFLRPLKYWQSSEDIYISQSQIRKFDLRPGDLVSGKCRAPKENERFFGLLQVNAVNGEPPEVAADRLHFPALTPLYPQNKLKLEQSPTHLSTRIIDLLAPVGLGQRGLIVAQPKAGKTLLLKEIANSISLNRPDMDLFVLLIDERPEEVTDMQRSVKGEVVASTFDEVPEHHIKVAELVLERAMRLVEQKRDVVILLDSITRLARAYNLVVPPSGRTLSGGIDPASFHRPKRFFGAARNIEEGGSLTILATALIETGSRMDDIIYEEFKGTGNMELHLDRKLAERRIFPAIDIRRSGTRREELLQSQEDLEKLWAIRKNMNDSMEYVEQFLKKLGRTKTNQEFIDSLDTSGMVPDASGSRTGGIRKPRSGSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMR0</accession>
    <name>A0A398CMR0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_22575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01187">
        <property type="protein sequence ID" value="RIE01187"/>
        <property type="gene ID" value="D3H35_22575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017213699" evidence="2">
        <location>
            <begin position="23"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="236" mass="25623" checksum="162A2A311CF6D5A8" modified="2018-12-05" version="1">MKRTFFIVIAAALWLTTGCSSSPSSDRYIEAAEQTPEPTPTASEQPVQTESPQAEQQPSESGSTESAQPEPSQAAPTQQGGNNAEQPPEKTSEPAKKQTKSQQVKEAKKNNDAVTKAVTDSIMDDSADKAAANGPEAERLKKSIEQIRSLVKDLKQQTESNDAAKIKDVSSQIAQAWEAMKADVDASYPDMTDFVQEKIGKLNELQAAETIDSKAMLQLDYELYQAFRQLADKAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMZ6</accession>
    <name>A0A398CMZ6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_04380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04726">
        <property type="protein sequence ID" value="RIE04726"/>
        <property type="gene ID" value="D3H35_04380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035097">
        <property type="entry name" value="M29_N-terminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000787">
        <property type="entry name" value="Peptidase_M29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02073">
        <property type="entry name" value="Peptidase_M29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00919">
        <property type="entry name" value="THERMOPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="410" mass="45180" checksum="393D6D359C9C9C8F" modified="2018-12-05" version="1">MEQFAERLKQYAALAVEVGVNVQPGQTLCIVSPVAAAEFTRHAARRAYELGVKYVHVEWSDEQITRARFELAPEEAFAEFPSWLAQGRVEMAEGGAAFLFVIADNPDLLTGIDSKRIAASTKAAQEALQPFRQFTQFNKVAWSIVAVPSQAWADKVFPGTVESERVDALWNAIFSATRVYEADPVANWRGHAETLQSKASRLNERKYRSLRYRAPGTDLTIGLPEGHLWVSAGSRNANGTAFIPNMPTEEVFTSPSRESVNGTVSSSKPLSYSGNLIDNFSLTFENGKIVDFSAEQGYDALKRLVETDEGSRYLGEVALVPHRSPISDMNLVFYNTLFDENAACHLAIGFSFPFCLEGGTALSKEELSERGLNQSLTHVDFMIGRADLDIDGVLADGSEEPVFRSGNWAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN04</accession>
    <name>A0A398CN04_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Galactose-1-phosphate uridylyltransferase</fullName>
            <shortName evidence="10">Gal-1-P uridylyltransferase</shortName>
            <ecNumber evidence="10">2.7.7.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">UDP-glucose--hexose-1-phosphate uridylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galT</name>
        <name evidence="13" type="ORF">D3H35_18280</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="10"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02629">
        <property type="protein sequence ID" value="RIE02629"/>
        <property type="gene ID" value="D3H35_18280"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00571">
        <property type="entry name" value="GalP_UDP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000766">
        <property type="entry name" value="GalP_uridyl_Trfase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39191">
        <property type="entry name" value="PTHR39191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006005">
        <property type="entry name" value="GalT_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 10 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="11">
        <location>
            <begin position="84"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_tr_C" evidence="12">
        <location>
            <begin position="266"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE02629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="528" mass="59198" checksum="A81AD8140532D8A4" modified="2018-12-05" version="1">MTTEEARVGTFPSEESVALCIERLVHYALRAGFIEGADIDFARNSLLDLFGLTESAEVAEGVASEPLPDSPVPLLEPLLDSAAAMGLMDDDTLTFRDLFDARIMGLLMPRPSETRREFERLVREQGVVAATDWFYRFNIDSNYIRMDRIRMNGYWRHSTPDGELEITVNLSRPEKDPREIALLKTLPPAKYPRCLLCKENVGYAGRRDHPARQNLRILPLSLSGENWYFQYSPYVYYNEHSIVFREEHVPMKISPETFARLLDFTESMPHYFIGSNADLPIVGGSILNHDHFQAGRHVFPMETAPVAEWYAASAEPEVRLGIVQWPLSVLRLRAADKQALLRTAKSVLDKWQSYSDPDAGIAAFTGDTPHNTITPIARFRDGGEFELDLVLRNNRTSEEHPDGIFHPHRELHHIKKENIGLIEVMGLAVLPGRLQQELADIAEILTGAAPFDSEALRAENHPLGKHADWIGELVAAYGTGNSAAHADQLLKSAVGDKFYAVLKDGGVFKAEPEGREAFRRFLVGTALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNG6</accession>
    <name>A0A398CNG6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02268">
        <property type="protein sequence ID" value="RIE02268"/>
        <property type="gene ID" value="D3H35_16180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017256551" evidence="1">
        <location>
            <begin position="29"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="218" mass="22419" checksum="616D5DB069157218" modified="2018-12-05" version="1">MTGISRKLSIIVLIILFAIGSIPGKFSASIGGISDVAAAANISGHDGIGYSGSIPGNEVAGTAFTGYQAWPSGLTKGSSGFIGGVYDGTSIWMIPYNADRLMKVNPSSGEMTGYSNWPAGFTKGSNAFAGGVFDGTNIWLIPYSANQVIKVNATTGEMTGYSGWPGGSKGSDQFVGGVFDGTHIWLTPYSGSRLIKVNITTGAMTAYNSWPSGTTLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNP7</accession>
    <name>A0A398CNP7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HD-GYP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_08300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03952">
        <property type="protein sequence ID" value="RIE03952"/>
        <property type="gene ID" value="D3H35_08300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="2">
        <location>
            <begin position="111"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="133"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="348" mass="39765" checksum="AE9CD3B2CB6A2391" modified="2018-12-05" version="1">MRVHITDVQSGDTLAQDIFNTYGLHVLSKGTLLSEKELSRLYQHQIEFLEIDWRQAEEPLDTAEEPSSYNPLLRPLYSDAVAGCEQLFEKALAEGRVYEGDLKESFQPLVDNFKSERDVVSLLLMLNNQDDYTYQHSVQVGMLSFYIARWMGWNEEETVRAGKAGFLHDIGKCRIPEAILNKPTKLTVEEFQEIKNHPNYGFEIVKNSFNDNMLAIAALQHHERMDGTGYPLGLKAEAIHPIARIVAVADVYSAMISSRVYKEKKDLLFVLKELFELSFKELDPTTTHTFIRHMLPNFIGKKVELTDGTTGTIVMSNPTDFFRPLVQVDEAFIDLAQVRTLEIKNVQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNR4</accession>
    <name>A0A398CNR4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type I addiction module toxin, SymE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01557">
        <property type="protein sequence ID" value="RIE01557"/>
        <property type="gene ID" value="D3H35_24720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014944">
        <property type="entry name" value="Toxin_SymE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08845">
        <property type="entry name" value="SymE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SymE_toxin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="57" mass="6496" checksum="537FAA8FEDD08607" modified="2018-12-05" version="1">MAKKKRVLTVSSAFINNQLIPQIRIQGKWLNDLGFSIGYKVVVEEIQGQLIIRVVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP06</accession>
    <name>A0A398CP06_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01045</name>
        <name evidence="1" type="ORF">D3H35_03040</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000008">
        <property type="protein sequence ID" value="RIE05332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05116">
        <property type="protein sequence ID" value="RIE05116"/>
        <property type="gene ID" value="D3H35_03040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05332">
        <property type="protein sequence ID" value="RIE05332"/>
        <property type="gene ID" value="D3H35_01045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="252" mass="26042" checksum="082F004CFB1A8443" modified="2018-12-05" version="1">MRLSGKVAVITGAASGMGKAIAELYASEGAKVVVSDLRIDAAQTVVTDIESKGGTAIAIAANVAKEDDVQNLIDTTVKTFGTVDILVNNAGIMDNFVPAADLTDELWERIFAINTTGPMRTTRKVLPLFTEKKSGVIVNIASAGGLQGSRAGAAYTASKHAVVGFTKNVGFQYATQGIRCNAIAPGGVNTNIGTSITEPNPFGMERAMAGISLNPRAGEPEEIAKVALFLASDDASFVNGTVVTADAGWTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP11</accession>
    <name>A0A398CP11_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">KamA family radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_08220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03940">
        <property type="protein sequence ID" value="RIE03940"/>
        <property type="gene ID" value="D3H35_08220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="PTHR30538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01070">
        <property type="entry name" value="PLP-dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00238">
        <property type="entry name" value="TIGR00238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="85"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="390" mass="44465" checksum="50B0F871436C2D1B" modified="2018-12-05" version="1">MPQPKYITDIGKIAQLPETERENLKSITNKFVFRVNDYYLKLIDWNDPNDPIRKLVIPNEGELKEFGRWDASDEDTNYVVPGCQHKYDSTALLIVSEVCGAYCRYCFRKRLFRNDVKEATSDVEPGLDYIASHPEISNVLLTGGDSLILAAPKLRAILQRLREIDHVKIIRLGSKIPVFNPMRIYEDEELLAAIREFSGPEKRIYVMAHINHPREITPEAVRGFDALHKAGAIVVNQTPVLKGINDNPKVLGELLDRLSWAGVTPYYFFINRPVAGNREFVLPLEKVYRIVEEAKSLTSGLGKRVRLAMSHTSGKIEILAIENGMAYLKYHQSRDGQYGRFMMLDCPKDASWFDDLPGSDRYWTPPQKKTEAVVSVNALSDMPVQRVKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP90</accession>
    <name>A0A398CP90_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LrgB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_08455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03980">
        <property type="protein sequence ID" value="RIE03980"/>
        <property type="gene ID" value="D3H35_08455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007300">
        <property type="entry name" value="CidB/LrgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249">
        <property type="entry name" value="PTHR30249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04172">
        <property type="entry name" value="LrgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="227" mass="23589" checksum="3B0E6AAA93BFBA8B" modified="2018-12-05" version="1">MSAQWMNQPLFGVAVSVIAYSVSLLVHERVRWLHPLFVGAGSLILLLSLADIPYEYYEKGGELLTFFLGPATVALGVPLYKHRERIRFQLLAVLSGISVGAIAAIVSTGLLVWGLGGSREAILSAMPKSVSSPIALELSRLTGGNPELSATLTVVTGLVGSMLGGAWLKLLGISGELPLGIATGTAAHGIGTAKLLRQSESLGSYSGFAMAVNGILTGIMYIPLSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPF9</accession>
    <name>A0A398CPF9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sigG</name>
        <name evidence="8" type="ORF">D3H35_06555</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04272">
        <property type="protein sequence ID" value="RIE04272"/>
        <property type="gene ID" value="D3H35_06555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014212">
        <property type="entry name" value="RNA_pol_sigma-G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02850">
        <property type="entry name" value="spore_sigG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="260" mass="29996" checksum="4BEB8FAD7F202303" modified="2018-12-05" version="1">MTRNKVEICGVDTSKLPVLTNAEMRELFLALQTRGELEAREKLVNGNLRLVLSVIQRFNNRGEFVDDLFQVGCIGLMKAIDNFDLGQNVRFSTYAVPMIIGEIRRYLRDNNPIRVSRSLRDIAYKALQIRDQLTNQHSREPTILEISEVLNVPKEDIVFALDAIQDPVSLFEPIYHDGGDPIYVMDQISDDRNKDIQWIEEIALREAMRKLNDREKMILSMRFFEGKTQMEVADEIGISQAQVSRLEKSAIQQMQKHVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPG8</accession>
    <name>A0A398CPG8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_06625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04282">
        <property type="protein sequence ID" value="RIE04282"/>
        <property type="gene ID" value="D3H35_06625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="5">
        <location>
            <begin position="43"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="335" mass="36683" checksum="33B8890A2906FE02" modified="2018-12-05" version="1">MTTANSLGKNNPSEDWNVSGLNDSGESIGKELEWVVSAEEAGERLDKHVTERFEDESVSRSQVQDWIRSGAVTVGGRTGKPNAKLQAGDAIVVNVPEPEPFEAMPENIPLDVVYEDGDVIVINKPRDFVVHPAAGHASGTVVNALLHHCKDLSGINGVMRPGIVHRIDKDTSGLLMAAKNDLAHASLAEQLKDHTVTRRYYGLVYGLIPHDKGTIDAPIGRDPDDRKLFTVTDKGAKRSVTHFNVLERLGDYTFVELKLETGRTHQIRVHMKYIGHSLVGDPVYGGRKGRTLGMTGQALHAGVLGFTHPRTGEYLEFTAPLPEDMAHALDILRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPI6</accession>
    <name>A0A398CPI6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small, acid-soluble spore protein, alpha/beta type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_23825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha/beta-type SASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01401">
        <property type="protein sequence ID" value="RIE01401"/>
        <property type="gene ID" value="D3H35_23825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001448">
        <property type="entry name" value="SASP_alpha/beta-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018126">
        <property type="entry name" value="SASP_alpha/beta-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038300">
        <property type="entry name" value="SASP_sf_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00269">
        <property type="entry name" value="SASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00304">
        <property type="entry name" value="SASP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="58" mass="6570" checksum="7D1D0C451905189B" modified="2018-12-05" version="1">MSRRRSVMSETFKAELAKDLGFYETVQREGWGGIRAKDAGNMVKRAIQIAEQQAARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPT0</accession>
    <name>A0A398CPT0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Flagellar biosynthetic protein FlhB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">flhB</name>
        <name evidence="14" type="ORF">D3H35_11460</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the type III secretion exporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03299">
        <property type="protein sequence ID" value="RIE03299"/>
        <property type="gene ID" value="D3H35_11460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006307">
        <property type="entry name" value="BsaZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006136">
        <property type="entry name" value="FlhB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006135">
        <property type="entry name" value="T3SS_substrate_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029025">
        <property type="entry name" value="T3SS_substrate_exporter_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30531">
        <property type="entry name" value="PTHR30531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01312">
        <property type="entry name" value="Bac_export_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00950">
        <property type="entry name" value="TYPE3IMSPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160544">
        <property type="entry name" value="SSF160544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00328">
        <property type="entry name" value="flhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01404">
        <property type="entry name" value="FlhB_rel_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="11 12" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="5 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="14" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE03299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="364" mass="41538" checksum="D8FCD6820695D61F" modified="2018-12-05" version="1">MSRLRHRLDLQLFAGEKTEKATPKKRQDTRNKGQVASSPDVPGALIMLGSLTCFLMLGSFFQTRLLAMFSDVFRHRMSMDITETNVMNLFGHYVLQILIFLAPLFVIVFVIIFAANYAQIGWLFTTETLKPQFNKLNPISGAKQIFSMRSVVEFLKSSLKLTVVGVVVYLMLWSERDRFLGLAHVPIEDIFAFAAELTIKLGMFVSAILFVIAIGDFIYQKYEHEKSLRMSKQDIKDEHKNIEGDPLIKGKIRERQRRMALMRMMQEVPKADVVITNPTHYAVALQYDGTKMDAPTVMAKGQDYLALRIREIAKKNDVVIMENKPLARGLYERTEIGDTVPGDLFQAVAEVLAYVYRLKGRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPU0</accession>
    <name>A0A398CPU0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nodulation protein NfeD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_06155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04200">
        <property type="protein sequence ID" value="RIE04200"/>
        <property type="gene ID" value="D3H35_06155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="366"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="462" mass="48605" checksum="EC123540FF80D705" modified="2018-12-05" version="1">MRRRSSLVPFDIVRKGDSRSFWAKVLLIAAFGLSVFGFATTEQAAAASEGAVYVVPVKQTVESGLASFIDRALTEAEEAKASLVVLDVNTPGGELRTAEEIGTRIRTAKVPTVAYVTGKAASAGAYLTLNAGGIAMAPGTSIGAAMIVDANGQPIENPKYVSFWTSEMVAAAQLNGRNPDIAVGMVDPGRVVELKELGRTKDKGQIITLSAQDALKVGYADKLASSVEEVLAWKGLSDRTVVEFNPSFSERLAEFVTGSGVSTILLILGIAGIAIEMLVPGFGAPGIVGLLSFGLYFFGHAIAGFAGMESIVFFVLGIAFLVFEMFVPSFGILGLLGCAGVVAGIAMAANDTGDAVRSLGWAVLAAAVIVAVFAYIFRRKGIWNKFILRERLSTEGGYVPNEPRESWLGQEGIALTTLRPAGIAEISGSRVDVVTSGEYVDRGTPIIVTAIDGTRIVVKERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPZ3</accession>
    <name>A0A398CPZ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Stage V sporulation protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">spoVE</name>
        <name evidence="8" type="ORF">D3H35_06490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04260">
        <property type="protein sequence ID" value="RIE04260"/>
        <property type="gene ID" value="D3H35_06490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013437">
        <property type="entry name" value="FtsW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011923">
        <property type="entry name" value="RodA/MrdB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013438">
        <property type="entry name" value="SpoVE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02614">
        <property type="entry name" value="ftsW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02210">
        <property type="entry name" value="rodA_shape"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02615">
        <property type="entry name" value="spoVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="365" mass="38720" checksum="C2F8293A96499ABE" modified="2018-12-05" version="1">MNKTRTIPDIWMIAATLGILAIGVVMVYSASAVAAFHDYGDPYYYVKRQLIFAALGVVAMFVTMNVDYHMLRKWALPALLVCFGLLLLVLVPGIGNVRGGARSWLGIGSFGIQPSEFMKLAMILFLARLLSERQQLMPSFARGLLPPLGILGTAFGLIMLQPDLGTGAVMIGAALLVIYVAGAKLSHLGGLALVGAAGFGALIAAAPYRLLRITAFLDPWQDPLGAGYQSIQSLYAIGPGGLVGLGLGMSRQKYNYLPEPQTDFIFSILAEELGFIGGALLLALFLLLIWRGMRTAITITDPFGSLLASGIVGIFAVQVLINIGVVIGMMPVTGITLPLVSYGGSSLTLLLTALGILLNLSRHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ76</accession>
    <name>A0A398CQ76_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sporulation membrane protein YtaF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ytaF</name>
        <name evidence="7" type="ORF">D3H35_20105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02918">
        <property type="protein sequence ID" value="RIE02918"/>
        <property type="gene ID" value="D3H35_20105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003810">
        <property type="entry name" value="Mntp/YtaF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014205">
        <property type="entry name" value="Spore_YtaF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35529">
        <property type="entry name" value="PTHR35529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02659">
        <property type="entry name" value="Mntp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02840">
        <property type="entry name" value="spore_YtaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="229" mass="23881" checksum="C814AF6309C0B995" modified="2018-12-05" version="1">MFAHLASLLILSFAVSLDGFGVGITYGVRKIRIPAGSIVIISACSGLIILLSMLAGAAMSGWMSPHGASIVGAVILIGIGGWALSQFFRNREDEDGDKTTSDAEERHRPAKPAETQRPVITLELKLFGIIIQILRKPSAADVDRSGIISAGEAFLLGTALSLDAFGAGIGAGLVGFPPNLTAVLIAAASGTFLWLGTRVGFIAAGWSWVNRLTVLPGIILIAMGIFKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ89</accession>
    <name>A0A398CQ89_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04622">
        <property type="protein sequence ID" value="RIE04622"/>
        <property type="gene ID" value="D3H35_03775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="83" mass="9502" checksum="4CBB691859B3733E" modified="2018-12-05" version="1">MPGEAYRPEESVLTRRKAGYQQTTRDFAEWSDRAEKRIVKVVVVLLVALVVSQTAIRIPAVRSWLTLTDKWEGIPFQKETPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQA9</accession>
    <name>A0A398CQA9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04715">
        <property type="protein sequence ID" value="RIE04715"/>
        <property type="gene ID" value="D3H35_04320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="379" mass="40659" checksum="8F4DB7FA88FBE29F" modified="2018-12-05" version="1">MTALFAESMVPRPTDERSTAIPAESMVPRPTDARLTALFAESIVPRPTDERLTALPAESMVPRPTEARLTALFAESIVPRPTDERLTALPAESMVPRPTEARLTALFAESMVPRPTDARLTALPAESKVPHPTVARLTALLAESMVPRPTDARLTALFAESKVPHPTDARLTALFAESIVPRPTDARLTALPAESKVPHPTDARLTALFAESIVPRPTDARLTALPAESRVPRPTDARSTALFAESMVPRPTDARSTALFAESTVPRPTDARSTALPAESTVPHPTDARLTALFAESKVPRPTDARSPALFAECKVPRSTDARLTALPAESMVPRPTDARSTALPAESIHFIPAGGNPLVLWALQGKLYPENVIVLGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQF5</accession>
    <name>A0A398CQF5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_20755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03028">
        <property type="protein sequence ID" value="RIE03028"/>
        <property type="gene ID" value="D3H35_20755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="212"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="315" mass="35530" checksum="BE28B1D65D36589C" modified="2018-12-05" version="1">MEPAGKGFAFAVDQYLGVILKENAEWIDRATLKTLYKQTSAACADSEVDFIAVSGGVVEEPKLLAGSFRRARDIMKDRFWLDGGLVHTEPYRKPEEAEGPDLSVAMEKLFLALDIGNESAASSLLLATGAAMREAGAHEQDMKAGLVRVMGTVLGKLGQSRPEIREKSHLFSDRLMDLYKEYRHAGLLDRLAGLAKQIADELRSFGTDKQIQKMLEMIERNYSENLKLESLAEVFNYNSSYLGKLFKNTTGQYFNTYLDKVRIEKAKELLEQGMKVYQVAERVGYTNVDYFHSKFRKYVGTSPSDYRKKQQTDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQG6</accession>
    <name>A0A398CQG6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 20">Methionine synthase</fullName>
            <ecNumber evidence="6 20">2.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19 20">5-methyltetrahydrofolate--homocysteine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">metH</name>
        <name evidence="31" type="ORF">D3H35_04660</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31 32">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18 20">Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:11172"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.1.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 20 23">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 20 22">
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 20">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="20">Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the vitamin-B12 dependent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="6 20"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04773">
        <property type="protein sequence ID" value="RIE04773"/>
        <property type="gene ID" value="D3H35_04660"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042558">
        <property type="term" value="P:pteridine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02069">
        <property type="entry name" value="methionine_synthase_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033706">
        <property type="entry name" value="Met_synthase_B12-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011822">
        <property type="entry name" value="MetH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004223">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02965">
        <property type="entry name" value="Met_synt_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000381">
        <property type="entry name" value="MetH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="SSF56507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02082">
        <property type="entry name" value="metH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50974">
        <property type="entry name" value="ADOMET_ACTIVATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 20" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 20 22" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="17 20 21" id="KW-0170">Cobalt</keyword>
    <keyword evidence="13 20 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 20" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8 20 24" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 20 22" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11 20 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="15 20 21" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="26">
        <location>
            <begin position="7"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Pterin-binding" evidence="27">
        <location>
            <begin position="339"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding N-terminal" evidence="30">
        <location>
            <begin position="620"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="29">
        <location>
            <begin position="713"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="AdoMet activation" evidence="28">
        <location>
            <begin position="861"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Methylcob(III)alamin binding" evidence="22">
        <location>
            <begin position="723"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="857"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="22">
        <location>
            <begin position="1144"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="857"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="21">
        <location>
            <position position="726"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
            <dbReference type="ChEBI" id="CHEBI:27638"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="771"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="827"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1090"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR000381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="RIE04773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1150" mass="126422" checksum="AC88812DAA979DDC" modified="2018-12-05" version="1">MTLTDLKPSLQAALKERILFLDGAMGTMIQQENLTEDDFGGAELDGCNEILVLTRPDVISRIHEAYLEAGSDLIETNTFGATSVVLAEYDIPEKAREINLAATKLAREACDKYSTPDKPRFVAGALGPTTKTLSVTGGVTFEELVDSYYEQVAALIEGGADCILIETCQDTLNVKAASIGVRQAFEEAGVELPIMISGTIEPMGTTLAGQNIESFYVSLEHLKPVSVGLNCATGPEFMRDHIRTLSGIADTAVSCYPNAGLPDENGHYHESPDSLARKLRAFAEQGWINIAGGCCGTTPAHIAAMAEAMKDLPPRKQEGQHPPAVSGIETVFIEDDNRPIMIGERTNISGSRKFKRLIKEGKFDEASEIARSQVKGGAHIIDINLQDTDIDEAFAVNNFLPMVTKKIKVPLMLDSTYDHIIELGLKYSQGKAIINSINLEDGESKFEQILPLIHRYGAAVVCILIDERGQAVSREAKMEVATRSYELLVNKYGMVPDDIIFDPNMFPVGSGDPQYIGSAVETIEGIRMIKEKYPRAKTILGLSNISFGLPDAGREVLNSVYLYHCTKAGLDYAIVNTEKLERYASIPEEERRLAEELIYNTNDDTLAAFVAAFREKKVEKKVKISNLSLEERLAGYVVEGSKEGLAADLDEALGKYAPLEVINGPLMSGMEEVGRLFNGNELIVAEVLQSAEVMKAAVAQLEPHMEVNESAVKGKIMLATVKGDVHDIGKNLVEIILSNNGYKIINLGIKVPPEQIIEAYRSEKPDAIGLSGLLVKSAQQMVLTAQDLRTAGIDAPILVGGAALTRKFTKTRIAPEYEGVVLYAKDAMDGLDIANKLTDPTHRARIEEDHWAGQAALAEEGEKQQEKPTLTRARKSDISQDAPIFTPPDYDRHVLRDYPLTHVLPYVNLQMLMGHHLGLKGNVDELLAAGDERTVQLKATIDEIMREAQVHGWLKPQAMYRFFPAQADGNDVVIYDPADTSRVLKRFSFPRQQVDPFLCLSDFLKTVESGIMDSVGFLVVTAGRGTRDQAEKWKESGDYLRSHVLLATALEVAEGMAERVHHMMRDIWGFPDSAELTMKQRFGARYQGIRVSFGYPACPDLEDQGPLFELMQPEDIGVELTEGFMMEPEASVSAMVFAHPEAKYFNVEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQI7</accession>
    <name>A0A398CQI7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-ketoacid dehydrogenase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04793">
        <property type="protein sequence ID" value="RIE04793"/>
        <property type="gene ID" value="D3H35_04795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="4"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="325" mass="35435" checksum="A666440AEF46AEB8" modified="2018-12-05" version="1">MAQMTMIDAIKDAMRVELKRDPNVLVFGEDVGKVGGVFRATEGLQNEFGEQRVFDTPLAESAIGGLAVGLGTQGFRPIAEIQFVGFIYEALDQMFVQAARMRYRSGGRYNSPIVFRTPFGGGVKAAELHTDSLEGLAIQTPGIKVIVPSNPYDAKGLLISAIRDNDPVFFMEHLNLYRAFRDEVPEGEYTVPIGKAKVVREGKDVTIISYGLMVHTAVKAAEELEKNGVSAEVIDLRTLLPLDIDTIVASIQKTNRAIVVQEAQKTSGAAAEIIAQINEKAILHLEAPVLRVAGPDTVYPFAQVEDAWLPTPARIVKAVNQVLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQL9</accession>
    <name>A0A398CQL9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_12995</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01721">
        <property type="protein sequence ID" value="RIE01721"/>
        <property type="gene ID" value="D3H35_12995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07477">
        <property type="entry name" value="Peptidases_S8_Subtilisin_subset"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034202">
        <property type="entry name" value="Subtilisin_Carlsberg-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017340761" evidence="5">
        <location>
            <begin position="28"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="7">
        <location>
            <begin position="387"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="535"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="7">
        <location>
            <begin position="619"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="760" mass="82187" checksum="DC532E90B52D7A6B" modified="2018-12-05" version="1">MLSKYLKWTVIASMLSLSIAAVSPASASVKEPEKIVDKQLLRNPSEEKRIIVRYKPEAAAERKASKKKYKAHKNFKHLNAEAMTVTSQELEELIADKSILSIEEDGIVQVEAQVADWGIERVQADHSWANGITGDGVKIAVFDTGVADHEDLTILGKVNYTASSTASDLNGHGTHVAGIIAALDNTIGTVGAAPDVDLYSVKVLEDDGTGLYSYVIDGIDWAIDNDIDIINMSLTGTGNSLALEEACDTAFDNGILLFAAAGNESTNSSGDDPTRYPAGYDSVIAVANGNSTDGRNSNSNKGPHLELTAPGTAVYSTHIGNAYTSRSGTSMASPYAAAVAALYMEQNPTYTNVQIRNKLIETADDLGDPGRDSSFGYGMVQAPFRNPSGTGLYAEYFNNANLTDLAMTRIDSQVSFYWGTGSPAAGIDPDTFSVRWSGQVLPLYSETYEFTTITNDGVRLWVDGQLIIDDWNNRSVFTPNSGTISLTGGQKYDIVMEFYENVDSAGADLLWYSLHQNQEFIPKRLLYPAVPSLAAPTGLAATAGPGYASLNWNASFGATSYNVKRATASGGPYTTIASNVTSTSYYDIGLSYNTTYYYVVSAVNGSTESANSAQASATIEVNGLRAEYFNNKDFTSPMALRTDANINFNWGTGSPAPGVDPDTFSVRWTGYIKPQYSETYTFYTNSDDGVRLYVNNVLVIDNWTDHGLTENSGTITLTAGQKYHIKMEYYDNIFDAVAQLSWSSSSQSKQIVPTNRVYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQR0</accession>
    <name>A0A398CQR0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000035">
        <property type="protein sequence ID" value="RIE03609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03609">
        <property type="protein sequence ID" value="RIE03609"/>
        <property type="gene ID" value="D3H35_10745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="130" mass="14555" checksum="53B7DF540058E294" modified="2018-12-05" version="1">MGRFLLDRRSGRSVLQAAPVTTRANADFDKLPLNSVEVKIEYKQGAEHSIKEFDLRSPDDLGKFASFIANDSYKYKYSYQVNYKGEAQAYQSPEIESDEENLTINVGDIGILLVDVAPGDLNFNQVSEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQZ4</accession>
    <name>A0A398CQZ4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Small acid-soluble spore protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_13760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01851">
        <property type="protein sequence ID" value="RIE01851"/>
        <property type="gene ID" value="D3H35_13760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001448">
        <property type="entry name" value="SASP_alpha/beta-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038300">
        <property type="entry name" value="SASP_sf_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00269">
        <property type="entry name" value="SASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="97" mass="10664" checksum="4769CC95DC203512" modified="2018-12-05" version="1">MSRRSRRRLLVPGAEQGLNAFKANVMRGEGYEVDPSRPDDVKYEVARSLGVPLQAGDNGRLRTEEAGRVGGKIGGTMVREMIRLAQAQLTEQPSKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR46</accession>
    <name>A0A398CR46_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01901">
        <property type="protein sequence ID" value="RIE01901"/>
        <property type="gene ID" value="D3H35_14060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="119" mass="14057" checksum="7AD2AC645CE8873B" modified="2018-12-05" version="1">MVEEESDVNQHDKCSVEWTLDVIGGKWKGVIVFHLLEGKKRFNEFRRRIPGVTQRMLTLQLRELERDGVVHRKVYSEVPPRVEYSLTEFGQTLEPIIRNMKTWGDEYARRVAERQAEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR64</accession>
    <name>A0A398CR64_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_02685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05055">
        <property type="protein sequence ID" value="RIE05055"/>
        <property type="gene ID" value="D3H35_02685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="125" mass="13528" checksum="C21EF1BA9EE3376A" modified="2018-12-05" version="1">MISEMTKNNCSFCSSISASAILLDGEMYLLQLINCSSNGQGERGADFHENTGYRSEASFFEVQRTTKAILIGQIKVERGIVARTASVAVRICPAAVASTVFIRAGVRFYPIAAHFSNMVVCIAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRQ4</accession>
    <name>A0A398CRQ4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D3H35_05190</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04860">
        <property type="protein sequence ID" value="RIE04860"/>
        <property type="gene ID" value="D3H35_05190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="283"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="446"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE04860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="562" mass="64681" checksum="18042161C9A940F2" modified="2018-12-05" version="1">MEKQVIGHQHQTIGLIENNIKMMLDDAQDISSYIMNNETFQNLLNQPKPEEYNRAQQTMLSYLSNLKTAKSYISFIIVYGENGFVFRDFKDFYREVVPYQQLNESPTYIATAAKEGEANWMFSSDPLFPYLQQYNEVMVGRRITNIYDSEEKLGMLFMGIGREAFLASIQDVELSDSTQLLLVDDNYNLVASNQKNRDVDYYRESDLEFKKRLIHPGDNPVIRVNGQDFYISTAKVEPYEWMVVSLTPLKEIREQHQVLLKFTLIASVSVMLIVALLSIFLSRNVTSPIRKLLRSMNDFKRGDFNQKVAVESKDEVGLLTQKYNQMVAELNELIQKVYISQTNQKMIELKTLQAQIEPHFLYNTLDYIFLNSKINGDDETAEVVRSLSQLFRISLNRGSDYYSMENEINQIKAYVNIQQARFPSRFKVEYEIDPKVEPYLTSKLLLQPIVENAIIHSFDHKEKGEGVLRISGGLSEDGIVFVVEDNGKGMTEEQVAALLQVSPNGSGGYGIKNVNERLTMLFGEEYRLRIASKIGKGTTVTIRLPIIHNEEEWVSLYENHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS24</accession>
    <name>A0A398CS24_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein-glutamine gamma-glutamyltransferase</fullName>
            <ecNumber evidence="1">2.3.2.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.13" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05382">
        <property type="protein sequence ID" value="RIE05382"/>
        <property type="gene ID" value="D3H35_00935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003810">
        <property type="term" value="F:protein-glutamine gamma-glutamyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00727">
        <property type="entry name" value="Tgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020916">
        <property type="entry name" value="Gln_gamma-glutamylTfrase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20085">
        <property type="entry name" value="TGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="261" mass="29881" checksum="7593AA32A4E28FCB" modified="2018-12-05" version="1">MIQITGFDVDKIDQSALSELERAILQKKLKSTVVYRYDSLEALLFELNMRSNIVEAAKALNSSRAGFATFQNSRANDQFWTRTDNGGFRQRTDVLASDAINDIFENSRLYAFECATAMVIILYKATLDSIGKDTFNAYFKDLFLYDWNYDNNLKLITVENKNEAYPGDVLYFENPDFDPKTPEWRGENAIMLADNLYFGHGIGIRTAEEMITALNARRKPGSTTSAFLTEQIEHPDFEYLRKLEKPFTARIGTRTYICIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSG0</accession>
    <name>A0A398CSG0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_06040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04179">
        <property type="protein sequence ID" value="RIE04179"/>
        <property type="gene ID" value="D3H35_06040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004761">
        <property type="entry name" value="Spore_GerAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34975">
        <property type="entry name" value="PTHR34975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03845">
        <property type="entry name" value="Spore_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00912">
        <property type="entry name" value="2A0309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="449" mass="50269" checksum="D8D4DD7820C11E09" modified="2018-12-05" version="1">MIHVVGIGRRHRARHCGMRVGYEAPSESALFGDGRLYVHTGDRLHSVHHVLAFDWAAEPDGVAHRNVQADRQLAVDALSGKVNPLMKERISVKQMTILVMFTIVGDTIIFIPAQTAAIAKQDSLLSACLSLLLGLGIGWIIWRLSLLLENSSFFEFNRSLLGKWIGSCIFGCYLFYFLLTGAAVVRNIGNFLVTHIMPQTPIRALLFILLITIVWTMKHGLETIARSGELLFPLAAVLFVMLIAFLLPDFNWSNMMPVLGEGVSPVLFGGIVTSGVTYGELIVIVMILPLVKREKNKKRDFFLGIALGGVVLTTITGVSILVLGQYLTSKHIYPSYAMARKISIGHFLERMEVILAINWIITSFFKSVIYYYGFVTGLSQWVKVPDYRLLIFPCAFLIYGISFLLAPNVVYFNLIGFKYWPYWDMTMAVLLPLALLAIHAVKRKKRLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSH8</accession>
    <name>A0A398CSH8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WG repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02331">
        <property type="protein sequence ID" value="RIE02331"/>
        <property type="gene ID" value="D3H35_16570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032774">
        <property type="entry name" value="WG_beta_rep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14903">
        <property type="entry name" value="WG_beta_rep"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="1">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="414" mass="43901" checksum="8670A0BEC06327F9" modified="2018-12-05" version="1">MGSRIDRGTLQLPLRGFGETIGASIAWDKATRTASISFGSRTLQLTAGSAKAVVNGEAYTLSAAPKLTDGKLWVPANSVAAALGAKITWNESKRTLSFERPLHVYASGGKEGFVNAFGEQVLKAGEYDSADEFSEGLALVGKDGKFGYIDIKGSQAIPLQFDQGYDFSDGLALVETGGKSSYIDAAGKTVLSPVYDELFDFSEGLALVRSGDLFGYIDHTGKEVIKPQFEDAFYFSEGLAAVQIEGSYGFIDRTGKVVIQPLYQSASDFKEGLALVQSDGSFGFVDPQGKLAIEAIYAKAFSFSDGLAAVENDGVVSYIDKNGKTVLETPYSETGDFHEGLASFLKDDKYGYLNLKGETVIAPKFDEAGNFTNGLARVVVNGKATLINAKGVEVANAKPPEAPVEEAAPATPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSQ4</accession>
    <name>A0A398CSQ4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-type ATPase subunit delta</fullName>
            <shortName evidence="6">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpH</name>
        <name evidence="8" type="ORF">D3H35_14595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="6">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATPase delta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01994">
        <property type="protein sequence ID" value="RIE01994"/>
        <property type="gene ID" value="D3H35_14595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="SSF47928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0139">CF(1)</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="181" mass="19018" checksum="5D04FA1546B919BB" modified="2018-12-05" version="1">MSRGSVVAKRYAKALFELAQAQNLVAAVENELKLVSEAVGGSAEIGAFLAAPNITVDKKIDALKSVFGGKVSTIVLNTVNLLIERGRQSEIPAVLEAYVQVAGGVLGRADAQVTSAQPLTEDQKSKLAAQFGTLLGKNVRVDNTVDPSILGGLTVRIGDTLYDGSLRGKLDRLTKELQASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSX6</accession>
    <name>A0A398CSX6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02064">
        <property type="protein sequence ID" value="RIE02064"/>
        <property type="gene ID" value="D3H35_14975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="97" mass="11364" checksum="91CE95ED9DF3744F" modified="2018-12-05" version="1">MDTRFETFERTVEQIVYSFYRYEINNGMRQLELFITQISELLIEYRVEGTRLDEINQLLQLILVSVENKDFLIVADLLKYELLGRVLLVSGSVGLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT20</accession>
    <name>A0A398CT20_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03908">
        <property type="protein sequence ID" value="RIE03908"/>
        <property type="gene ID" value="D3H35_08045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="114" mass="13022" checksum="E2D083C1B4696505" modified="2018-12-05" version="1">MLTVRQVVFRGVREQGGQRLAEVEVSTDHPKDSKLLAYFRSGPKGYQLVRVLSDKAGLETDWFDNRMHDAYDDVTMTMFAGPSHGGENDRSHFARQVLEYDGIVGDFDRNMRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT28</accession>
    <name>A0A398CT28_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02977">
        <property type="protein sequence ID" value="RIE02977"/>
        <property type="gene ID" value="D3H35_20455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="321" mass="34602" checksum="59BE3443672AA332" modified="2018-12-05" version="1">MRAIKCAKYGTPDVLRLGEVQKPTPKDNEVLIKINATVVTPADCAFRKADPFITRFFCGLTKPKFVPGVELAGEVEAVGKDVTLFKRGDSVFGAAATGFGAHAEYKCLPETGVVALKPSNMSCEEAVAVCDGGLTALTFLRDIAKIQSGQKILINGASGAVGLYAVQLARYYGAEVTGVCSTTNAALVKLYGVDKVIDYTKEDFTKTGQTYDIIFDAVGKSSFSHCKGSIKPRGMYLGTVPTLAILFQTLWTSKFGSKKAIFSATGLKQSKENLIFLKELAEAGEIKSVIDRRYSLEQIAEAHRYVETGRKKGNVVITLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT60</accession>
    <name>A0A398CT60_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03948">
        <property type="protein sequence ID" value="RIE03948"/>
        <property type="gene ID" value="D3H35_08280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="61" mass="7175" checksum="767EA75250514795" modified="2018-12-05" version="1">MNIKMTNEWRISLFAGIAERIGTRTLRERLAETRLLASDANLVWMTRFPDNSRSHKPLLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT65</accession>
    <name>A0A398CT65_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1761 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02154">
        <property type="protein sequence ID" value="RIE02154"/>
        <property type="gene ID" value="D3H35_15510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013879">
        <property type="entry name" value="DUF1761"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08570">
        <property type="entry name" value="DUF1761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="133" mass="13814" checksum="1C2C0556380A879A" modified="2018-12-05" version="1">MFHLEDINYVAVLAATVATMILGFLWYSPILFGGAWMKQIGKKAEDMSGGGPLTYVLTAATALIGSWILAAIVTLTDGTVGAGVIAGLLIGIVVSAKIGMNYLFEGRSGGLFIITSGYHVVSFLLSGLIIGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT66</accession>
    <name>A0A398CT66_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HintN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_07645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04449">
        <property type="protein sequence ID" value="RIE04449"/>
        <property type="gene ID" value="D3H35_07645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HintN" evidence="2">
        <location>
            <begin position="379"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="558" mass="60431" checksum="B569C0AC820ABB38" modified="2018-12-05" version="1">MINLTNEQKELFAYIDGILPGDGHLKYDFRDEKQYEFAVMMSQLSGDADLYPGKLKSLELMKAYQEQHGLQENEPQTADGWTNMFKIPGLNLTTDGTIASNGLATVVGGYASMNLALIVQSRKTKDIVAHGFNNDFAKALLTVSTAASTSKEIDVNSYLHYQYTTSSGSETASPQSGLVKKQDNGGTTGDPVITAPARTTTKPNNPKAINIGLGRPWTDQGGDSQFDYAWYESTQDHPIGKIPFVGSATFSQAISTPLEPNTNFLLDIYVADEVGGGGAQLNPTDLDTVYKAFSIDSGNDAKLNWSLPAGASTTDPGNPIVFGNVTWSSDILAYFYCQIAVVLSGGDGSLAFATVQSSDSPDSDPLDGTYNMKPIDFIWHCLGQSTSVTMADGEQRPIADIVAGDKVQINSEGDFAVVQWTNKGAHKGDVYFIRTEGGDELIASHNHVIMTERGPVPASELQEEDVLLTRTGTSKVASISKDAYSGLMYNLATTEYQDPKHFNGEIGAFYANGLQVGDINAQKAYRLILANDMAWVKKQVPDYLHKDVESFFQAKKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT84</accession>
    <name>A0A398CT84_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="1 2">2.7.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">APS kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATP adenosine-5'-phosphosulfate 3'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenosine-5'-phosphosulfate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">cysC</name>
        <name evidence="3" type="ORF">D3H35_00870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the APS kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="1 2"/>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05370">
        <property type="protein sequence ID" value="RIE05370"/>
        <property type="gene ID" value="D3H35_00870"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Phosphoserine intermediate" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="201" mass="22501" checksum="8CCBACB32DD3C2C8" modified="2018-12-05" version="1">MDIDSRNVTWQPSNLTRHDRQRLSGHRGYVLWFTGLPGSGKSTLAFALEKELYARNIASYVLDGDNIRHGLSRDLGFSEDDRKENIRRVGEVSKLFVDAGLIVLVALVSPSRSDRRMVRAMFGPGDFMEIYVNCPLAECEKRDPKGLYKKARSGQIQSFTGVGASYDIPASPELVLNTQKLTVAESVSALIRYLEDRSCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTM8</accession>
    <name>A0A398CTM8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UV DNA damage repair endonuclease UvsE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">uvsE</name>
        <name evidence="8" type="ORF">D3H35_16530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02324">
        <property type="protein sequence ID" value="RIE02324"/>
        <property type="gene ID" value="D3H35_16530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004601">
        <property type="entry name" value="UvdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290">
        <property type="entry name" value="PTHR31290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03851">
        <property type="entry name" value="UvdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00629">
        <property type="entry name" value="uvde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0228">DNA excision</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="243"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="338" mass="38153" checksum="8422111182AB27D4" modified="2018-12-05" version="1">MLVRFGYVAMTMQLENASPSRTMTLTNFVKLPDREAALRRLERLAEENLHNTLRILKHNRYMDIRLYRFTSKFIPLKTHERLSDWNPYPVLADAFAEVGVFVRENGVRTSFHPDHFTVLSTPREEVLANSIKDLEHHVSMLELMGLDERSTCNIHVGGSYGDKEKAGQRFVNHFRLLEPRIAARLTVENDDKTFTALETLNICESTGAPMVLDIHHHAVNPGEERMEELWPRIKRTWDKQAWNADPGHAAGSDKLPPKIHVSSPKSASDPRGHADYVDPGPLMSFMLAIAGETPAIDVMIEAKRKDEALFKLMDDLRVLEAAGGPVKIVDGASVEIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTR4</accession>
    <name>A0A398CTR4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_16705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02354">
        <property type="protein sequence ID" value="RIE02354"/>
        <property type="gene ID" value="D3H35_16705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="342" mass="38493" checksum="3828E0AE7CE09E71" modified="2018-12-05" version="1">MAVTIKDVAKKAGVSPSTVSRVLSNHPRISRETTRKVKEIMEEMGYHSNIMARSLVSNKTYTLGMVLPRPAEELFQNQFFAENIRGITTQASRNGFDVLMTAGHSEQDELEAVTRLVKGRRVDGIILLQSRKNDPIIVFLKKEEFPFILIGHYGDDDILCVDNDNIQASFDATMHLISQGHERIGFVSGPPNLTVSQDRLEGYRKALAENGLRMLSEWIVEGEFLQESGYRAMSFFMNLPERPTALVVIDDIVTFGILRGLTELGFKVPQDLSLVSFNNITLAELSSPPLTSIDIGIYQLGYMASQLLIRQIQGDKPQLLRTIVPHRLFVRESSLNLKRNWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVE1</accession>
    <name>A0A398CVE1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_20390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02964">
        <property type="protein sequence ID" value="RIE02964"/>
        <property type="gene ID" value="D3H35_20390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="103"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="322" mass="35010" checksum="D56CFD17EA3D79E3" modified="2018-12-05" version="1">MYKSFLRKLPEAFITLFCATLIIFVLIRLAPGDPVKVLLSHSGEVAGSKQAYDEKAAELRAQWGLDRNMIVQYGEWTKRLLQLDLGASIHTGRPVGSEIAGRLPATIMLSVFALLVQVVLGLFFGTVSALKAGKTYDNVIRLACVTLASTPAFVMALFLLSFFAVTLNVYEISSEASFARLWLPGVTLGLMGAPPFIRIVRANLLSEFGKIYVLSAISRGLNRKRVVGHALRNALLPVITMVALSLATLVSGAVVTESIFSWPGAGKYALDSILLKDYPVIQGYALVMVSIVILINLLVEVAYALIDPRIHRRGEAGGERYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVV1</accession>
    <name>A0A398CVV1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_11690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03341">
        <property type="protein sequence ID" value="RIE03341"/>
        <property type="gene ID" value="D3H35_11690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025619">
        <property type="entry name" value="YlzJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14035">
        <property type="entry name" value="YlzJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="88" mass="9728" checksum="AEAADD97BF71EE66" modified="2018-12-05" version="1">MNLYTPMPLELVLEGYGNELPPMMEIVLGSMLVQVTPVAPGFGRIVRLIHAPLESFLLPQFEPGRIIAYSDHQASTVSMQNEMDQSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWD3</accession>
    <name>A0A398CWD3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_05235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04868">
        <property type="protein sequence ID" value="RIE04868"/>
        <property type="gene ID" value="D3H35_05235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="117" mass="14411" checksum="099B5CBD7A2C6683" modified="2018-12-05" version="1">MEDYQLENYVEKAYFLSEETKEAILEDIKFTLQVGKHRRDKEFEWSIRKIRNETVHIEANWNQLMTEQFDYQRMTLHLINLAIRIHNEQQNYQPVKEKQIRRFPKVVTRINELSREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWM5</accession>
    <name>A0A398CWM5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000035">
        <property type="protein sequence ID" value="RIE03611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03611">
        <property type="protein sequence ID" value="RIE03611"/>
        <property type="gene ID" value="D3H35_10755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="94" mass="9684" checksum="C4EAC69862562A88" modified="2018-12-05" version="1">MTLAIGDGSGTFADLQSVRSSGYPPFSALFNTALTSEQSGQATAALNGSPDRLTVTYRGQVQRSGQGAAQLAATADLSRWLPAGTSANYIRSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXF5</accession>
    <name>A0A398CXF5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_01735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05268">
        <property type="protein sequence ID" value="RIE05268"/>
        <property type="gene ID" value="D3H35_01735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005690">
        <property type="entry name" value="GerBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="441" mass="49275" checksum="5C9F1D026CFA6344" modified="2018-12-05" version="1">MQKRLEQIKNELFHTEDLMIRPFELEGQPAKLIYIETLCDATKLEISLFKQWFRARSNTYSKLEINYLLTAANIETVSDAKEAVHYLLQGKGLIGFDDSDELYAFNAEQSNIRSIQEPANELSIIGERAGFVEQLSVNLNLIRNRASSSLVKVRYFAIGKHATHKVAVVWIEGVAEKSIVSETIDRISRFHSSMEVHPGKLQRQLTAKRSIFPQIYSTERIDTATSLLMHGRIAVLTDQSSTCLVVPVSFYSFLNSVDALLLGRGTAWLLHSMIAIGLLLSLYVCSLYIATTMFHHEILPAKMTINIKSSMENVPYPPVVEAVIMILIFQLIAEATVRLPSQLAQLVGVAGGIIISESLVKIGFVSNVFIVIVALSMIGSFMIPAYQMRNFVLIVQIMLLIGASILGFYGIVFVTIGLLIHFFTLEPFGVPYCMPIRSHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYG2</accession>
    <name>A0A398CYG2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sigE</name>
        <name evidence="9" type="ORF">D3H35_06550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04271">
        <property type="protein sequence ID" value="RIE04271"/>
        <property type="gene ID" value="D3H35_06550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014200">
        <property type="entry name" value="RNA_pol_sigma-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02835">
        <property type="entry name" value="spore_sigmaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="8">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="240" mass="28000" checksum="83EC107EB2FE14B8" modified="2018-12-05" version="1">MLVKWKLMTQLSLYRLLFWLGWKSEEVYYIGGSEALPPPLSREEEEYLLERLSTGDAAIRAMLIERNLRLVVYIARKFENTGIHIEDLVSIGAIGLIKAVNTFDPEKKIKLATYASRCIENEILMYLRRNSKTRTEVSFDEPLNIDWDGNELLLSDVLGTENDTIYRNIEEQVDRKLLHKALDKLSDRERTIMELRFGLADGEEKTQKDVADLLGISQSYISRLEKRIIKRLRKEFNKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYK1</accession>
    <name>A0A398CYK1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methionine biosynthesis PLP-dependent protein</fullName>
            <ecNumber evidence="4">2.5.1.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_09015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.48" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04074">
        <property type="protein sequence ID" value="RIE04074"/>
        <property type="gene ID" value="D3H35_09015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102028">
        <property type="term" value="F:cystathionine gamma-synthase activity (acts on O-phosphohomoserine)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="386" mass="41868" checksum="0608E777F1069F74" modified="2018-12-05" version="1">MKIESRLAQIGSLEDPATGGVSFPVYHSTAFRHPRLGQSTGFDYARSKSPTRAVLEAAAAELEKGDAGFACSTGMAALQTIFAMFKQGDHLLVSLDLYGGTYRLLEQIMSRFGVTASYVDTNDLDGLESLSTPNTKAVLIETPTNPLMMVTDIGKVAAWAKSRGYLTIVDNTLLTPFFQRPIELGADIVIHSATKYLGGHNDVLAGLIVTKGEEVSAEIAFLHNSIGAVLGPQDSWLLMRGMKTLALRMERHQFNATRVAEWLQTNPAVETVYYPGLADHPGHDVQSKQSSGNTGILSFKMKDARTIEPILRHVKLIAFAESLGGVESLMTYPAVQTHADIPLEIRNAVGVDDRLLRFSVGIEHIDDIIADLGQAIQSAEKEVSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYY7</accession>
    <name>A0A398CYY7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="6">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaD</name>
        <name evidence="8" type="ORF">D3H35_07660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial CoaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04451">
        <property type="protein sequence ID" value="RIE04451"/>
        <property type="gene ID" value="D3H35_07660"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="16"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="20"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="99"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="134"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="175" mass="19722" checksum="74C0324EB8BC22A1" modified="2018-12-05" version="1">MGQHPVKNEQDKLTAVYPGSFDPVTFGHLDIIRRAAKQFDRLIVAVLNNTSKSPLFSVEERKALLAEVTRDLPNVEIDSFRDLLVRYMRSRQADVIVRGIRSVTDFEYELQMASTNRQLDEGIETIFMMTNPKYSYLSSSIVKEIAKFQGAVHDLVPPSVEAALIGKYGTGKEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZE5</accession>
    <name>A0A398CZE5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05227">
        <property type="protein sequence ID" value="RIE05227"/>
        <property type="gene ID" value="D3H35_01520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="163" mass="18789" checksum="7BBFEC36C35D6F79" modified="2018-12-05" version="1">MENIGQQASYVVLWLLLVAMCSILLFVLKEMNRLKRELQIQWTAFMANDTISKSPVVLFGSSDIWLFIDHKHPHNDIHIQKARQACKGHRMLIVLIGPQWKANALQKKLQDQTIWVDEKGKLAQLFRVTHFPQAITIGNDFRYQSLKWTEEGMSDEGSTAGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZH2</accession>
    <name>A0A398CZH2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_01680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05257">
        <property type="protein sequence ID" value="RIE05257"/>
        <property type="gene ID" value="D3H35_01680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="7">
        <location>
            <begin position="6"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="PKS_AT" evidence="8">
        <location>
            <begin position="896"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1260"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1263"/>
            <end position="1279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE05257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1328" mass="141205" checksum="0FBEFC5F581A96E1" modified="2018-12-05" version="1">MRFEPIAIVGQGCVFPGATSPEELWRIVAESRETLTEPEEGEWRLSRESSRRDPDGNEWSIRGGYIRGFRPAFDRMGLKIDPEQVLRMDRMVHWLLHAASDALGGAAAGTAALARTGAVIGNLSLPTVSLSRYAEHVWLMGQEGRIPDALIEQEIGEPSHAVNRFMSGYPAHFLAEALGLGGGAFCLDAACASSLYAIKLACDRLHDGKADLMLAGAVNATDPLFLHTGFRALKAISPTGRSRPFHSEADGLVPSEGCGFIALKRLADAERTGDRILGVIRGIGLSNDGGHGGLLAPAKEGQIRAMRQAYDMSGLAPSDISLIECHATGTSLGDAVEIQSMSDVFSGRSGIPIGSIKGNIGHPVTAAGMAGLMKVIRAMDEGVYPSTRQIGGPIRLLEGTPFRLPAPGEKWAEGAPRRAALSSFGFGGNNAHLIVERYEPVGIAKSIRNPLNQAAIRKDADLAIVGIGVSAGNCSTAGEWAAALLGARNGKAEPAAARSREIELSLKEITVPPVDLKQALPQQVTLLQTAAAAAAEAGGLSGERTGVYVGMQCDAEIARHIARVRVGEWALKHEDLFDADNPDALFASSLQNAFYGPLESSTVVGLLPNVPANRLNKHLKLAGPGFTVSSEELSGITALELASRALRNGELDAALAGAVDLSCETVHEAAAQAMLESGSQIPGDASVMLALKRLEDALRDGNTVYAVLPGHAEAAADPDLLLGWGEKDAVRLASSFGHPHAASGLLHVAAGALALHYGLLPFGAGRNMRPWLRGEKARSARVVVRALGEVSGTVLLKERAGGAASFVQHGSRLHQLHTYSALNRRELLQSLREGKESRTGAVRLAIVASGAKELSDRLAAAAAELERLIGDPDSTFREAPGIYYGDKPAGGELAFVFSGAASAYAGMGGELLAAIPELGDDIHDRFRTAAEAAGWAYEEYPNREPDPLSRLGGASYLTQIHAAFTQRWLGLRPQAVIGLSSGETNALAAMGAWRELDGLFRDLKSHGIYTRELAGTYRVLQDAWGEPNPQWTNWRVLASPSAVREALSSEERVHLTMIHAPKDCVIGGDPAACSRVLNKLKPALSYPLGYDMVVHSPELTGISELWKDIHRRPTAPVPGVRFYSGVSAKHYSPDIDRAADALLEMASGTVDFPRTILQAWEDGVRVFVEHGPRSLCSGWIGQILAGREHLCVALDQPGVNPLEQAASSAARLFASGTNLDTGRLQERLSELASGISQDVRGRGMTFPAHLPPVVLPRLQTRKPDAVRPNRQEEVKPLNKTEETAPLPPAPRAPMSGSRPPPSRLLVNMPGSLPHIAITWSCKALCSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZV9</accession>
    <name>A0A398CZV9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF177 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04454">
        <property type="protein sequence ID" value="RIE04454"/>
        <property type="gene ID" value="D3H35_07675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="203" mass="23186" checksum="9BE286B48827C488" modified="2018-12-05" version="1">MRIPFLASRILEALTKQPPHRYNNFCLFGVIPMLINVQELLSRQQPIEREGTFELKDLFRDSRDTTPLGPLSFRLTANAAGERRIGVTGELTADLRLLCSRCLDPIDHHFEVEFEEMFQVMKDTDPEPGEDDDFIPVYGERLELRPFLEEELVLNLPLAPLCREDCKGLCSECGTSLNEKTCGCGTEKIDPRLAALQDWFKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D008</accession>
    <name>A0A398D008_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000004">
        <property type="protein sequence ID" value="RIE05447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05447">
        <property type="protein sequence ID" value="RIE05447"/>
        <property type="gene ID" value="D3H35_00305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="88" mass="10094" checksum="94B7A86CA2BB8815" modified="2018-12-05" version="1">MNVVGKAVNDKLVNAIHSSMRQAYGCTKAFFLPERTMTARQCSFDRERESLNTMPGRWRALPRLNSKKVIRSGTGGRIFREVHADLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D012</accession>
    <name>A0A398D012_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04801">
        <property type="protein sequence ID" value="RIE04801"/>
        <property type="gene ID" value="D3H35_04850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="76" mass="8934" checksum="AF648C3D36977912" modified="2018-12-05" version="1">MVNCEHFRYLEPSRGPRPSRDFTFKFFTDGSLEIIDNDSGHTMNPRELSGGSYDFYVRQRIAFIKRDLHSKIAKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0U0</accession>
    <name>A0A398D0U0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NlpC/P60 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_04730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04784">
        <property type="protein sequence ID" value="RIE04784"/>
        <property type="gene ID" value="D3H35_04730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017478389" evidence="2">
        <location>
            <begin position="37"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="37"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="162" mass="17640" checksum="186099A649CFD648" modified="2018-12-05" version="1">MNFKRNFFKKIIIASMSAVIGLTGFALAGQAPSASAATKADKIISLGKKYMGVKYRFGAPSGVTYAFDCSSFTQYIFGKYGVKLPRISSTQATKGYKVAKANLKKGDLVFFTTARTGKKIGHVGVYVGNGKMLHTYGKPGVMYSSINSSYWKSHYVTARRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D302</accession>
    <name>A0A398D302_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000003">
        <property type="protein sequence ID" value="RIE05464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05464">
        <property type="protein sequence ID" value="RIE05464"/>
        <property type="gene ID" value="D3H35_00250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="92" mass="9899" checksum="3444CD2732EE3A14" modified="2018-12-05" version="1">MFQLRGQLLHESFLLGVPESGSPRRNRPSSTERDDFNRGAEIGPLCNYRNVSRSVKKRQPSSGACVAVGLAGARTSSAVTITLYLMSGCKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCK5</accession>
    <name>A0A398CCK5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_25495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00926">
        <property type="protein sequence ID" value="RIE00926"/>
        <property type="gene ID" value="D3H35_25495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="318"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="592" mass="65870" checksum="7E84C27A9FECED0F" modified="2018-12-05" version="1">MGIMRRLYRGFIDLKIQDKIFLCFVVVIIASVLGIGISSYYKSSAIFGKKTSRYNVETVQQISTSVDYTLERIDDLSGILAFDQTIQRVFNTDMGAMSERETIAAVNEIESIMITHYNSQIMRSIEIYGNNGLVVKVPSSFNEQGNGPTPKQFVEMASVYRGKTKWLNDAQEHGLLYAVREINELQTAVKPLGTVIISLKSSMVADLLKNVDFDQSGAVLLMDENGSPVIASEPFGQPQAVEEIRQIAAFSSGSSIQTIGGERYFVSFRTSEYTGWKTVGIISLDKLYEDSRMIREWMIVVTLVILLFAFVLARIFAQTITRPIKRMLIPMKKVQMGDLDVSFPSGGKDEIGILSTGVNHMVSQIHSLVEESYRGKILLQQSELKALQAQINPHFLYNTLESINWMAKMNGVDPICGMVTALGDLMRISINTEKEFITVEEEIKYISDYLYIQKVRFGDRVQADIRMEDELLPIVIPKLILQPIVENALLHGVQMKKGQGLIRVRGRKADGGDIIFEVEDNGGGMTAKQADALLADESIADPQAKGSGIGIRNVNQRIRYIFGKDYGVTVNSVPGEGTVVRIRIASSLPKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCQ4</accession>
    <name>A0A398CCQ4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000055">
        <property type="protein sequence ID" value="RIE00483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00483">
        <property type="protein sequence ID" value="RIE00483"/>
        <property type="gene ID" value="D3H35_28290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="114" mass="12366" checksum="8B1A3B31459FBC0E" modified="2018-12-05" version="1" fragment="single">MESESLTYAELNGRANQLARVLRGKGVGVDRIGDPGGAVAGDDRGDPGDPESRRAYLPIDPDYPAERIGYMLEDSGADILLTQKRLQGQTMGFAGEVLHVDDERLYALDDTDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCU9</accession>
    <name>A0A398CCU9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_29885</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00245">
        <property type="protein sequence ID" value="RIE00245"/>
        <property type="gene ID" value="D3H35_29885"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="338"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="177"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="274"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE00245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="476" mass="50935" checksum="61E504BE1B82AF15" modified="2018-12-05" version="1">MPFHSHATLLAFNRYPKKPGRNAFMKIAVIGTGVVGLTTGAGFADLGHSVLCVDIDAAKIAQLSKGLVPYYEPGLQELVTRNLDAGRLQFGGAPSHALRDAELLFVAVGTPTDDHGEMSLASLWSVIDRLEPWTGDSVKMIAIKSTVPVGTADRVEARLRSRLPEECLVDVASVPEFMREGSAVRDFFDPSRIVIGVASPETGARLELLHRRLPGGIIVTDRRSSELAKLASNAFLAVKISYANEMAALAEQTGADYPSVAKIMGHDPRIGPLFLNAGLGFGGSCLPKDTRALVRLADEAGAPQTLVAAAVRANVMLPLRTVRKLEAALSDPGRRKVALLGLAFKPGTDDMREAPSLRLAAELLRRNPGVRLTAYDPAAGEAARKLLPGAVKICATAEEALTGADAAIIVTEWREFRLFQAEDFKKWMNRPIIIDGRNSLDSEALNAQGVVCIGAGRLPAIPVEQIRLPGELLPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDF9</accession>
    <name>A0A398CDF9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_26420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00733">
        <property type="protein sequence ID" value="RIE00733"/>
        <property type="gene ID" value="D3H35_26420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014245">
        <property type="entry name" value="Spore_III_AF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09581">
        <property type="entry name" value="Spore_III_AF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="258" mass="27281" checksum="1A952DC282113FC6" modified="2018-12-05" version="1">MGIMDGLSGWLKQIIAVVLLASLVDLLLPNRTMQRYVRLVAGLFILLTVITPLLGWLKGDFGDRLAAGLSQVEEAPGGAPDQLAMIEQEGAKLRDRQAKQTSELVTARLAEQIRADVAQSEGRPVRSVDIKTDRNADGAWLVKEVAIVLDGTSPQADGHLSGEADSSGGAIADSASSPEKSASRPIADIAPVAPVDPVEVDIAGSERPDSFRPKNGAEPALAEPDIQVRTRIAAFVAARYGLPTDTVVVTETNAPTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDG5</accession>
    <name>A0A398CDG5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00465">
        <property type="protein sequence ID" value="RIE00465"/>
        <property type="gene ID" value="D3H35_28635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MurNAc-LAA" evidence="1">
        <location>
            <begin position="79"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="195" mass="21447" checksum="B52B3C6BF6908572" modified="2018-12-05" version="1">MPSADVLIDAGHGGIDGGTHYGTILEKDINLAISRKLYLLLCSKGIAAVLNRTGDYALSEENRWHATRSRHRRDLSQRSALPNDIAASIFVSVHVNWSKRGNNRGPLVLHRKDGRSSLLASFLQDSLNKQQKARGAARDEGRFYVLNAVKAPSVIIETGFLSDARDREMLTNPRGQTRIAEAIANGIIAYRSFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDN4</accession>
    <name>A0A398CDN4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2577 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01296">
        <property type="protein sequence ID" value="RIE01296"/>
        <property type="gene ID" value="D3H35_23210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022555">
        <property type="entry name" value="DUF2577"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10844">
        <property type="entry name" value="DUF2577"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="113" mass="11981" checksum="5143BF8EEFED56FF" modified="2018-12-05" version="1">MSLLNIIKKAGMGAVEAGQPVAVIVGTVANENPLEVTVDQRFVLTADFLIVPESLTEYEIDAKHTHSAAGGTTGAALTEKLLIRRGLEAGDKLILLRVQGGQQYLILDRVVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDT8</accession>
    <name>A0A398CDT8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoate--protein ligase</fullName>
            <ecNumber evidence="4">6.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_26795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10500"/>
            <dbReference type="Rhea" id="RHEA-COMP:10502"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.20" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00800">
        <property type="protein sequence ID" value="RIE00800"/>
        <property type="gene ID" value="D3H35_26795"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016979">
        <property type="term" value="F:lipoate-protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019491">
        <property type="entry name" value="Lipoate_protein_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="PTHR12561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10437">
        <property type="entry name" value="Lip_prot_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00545">
        <property type="entry name" value="lipoyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="8">
        <location>
            <begin position="27"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE00800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="330" mass="36664" checksum="D97B82964E590F32" modified="2018-12-05" version="1">MLFVDNGNCHDPSLNLALEEYILRNLPAEEDYLLFYINEPSIIIGKNQNTAEEVNAGYVSGQGIHVVRRLSGGGAVYHDLGNLNFSFLTRDDGKSFHNFRKFTEPVVEALRKLGVNAELSGRNDLQVGERKISGNAQFASRGRMFSHGTLLFNSEVDAIVSALNVNPAKFASKATKSVRSRVANIAEFLSEPLTMEQFRRSLLESIFGGASDIPEYKLTDSDWEAVRKLADERYRSWEWNYGRSPAFNVRQVKRIEGAGTYDVRLNIVDGVVAEAAVYGDFFGTGEVSDVTSKLVGVRYEPSAVADALSGVDLQPYFGPVDREEWLALLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDU4</accession>
    <name>A0A398CDU4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000051">
        <property type="protein sequence ID" value="RIE00605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00605">
        <property type="protein sequence ID" value="RIE00605"/>
        <property type="gene ID" value="D3H35_27485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="158" mass="18618" checksum="087AE9D754D1CF79" modified="2018-12-05" version="1">MKSVLLDSSASTFNLEWNSILDNGEVRRQAVYRYKVLFRHVDGTERPLSLQSPDIIERGDVVEILPRELYSIVPVPIQALNFPWERYSHVEVRTQYEDPEHRISQADSFVLSKETVTEASWKMFVMDSGKTRFRYKIIYRAVDFRTLSCPGWRRMRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDY2</accession>
    <name>A0A398CDY2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00840">
        <property type="protein sequence ID" value="RIE00840"/>
        <property type="gene ID" value="D3H35_26700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="100" mass="11082" checksum="5C135F12753F2591" modified="2018-12-05" version="1">MIRANTDRKWLPLYEALASGVRLSVLELLAEKPMNVKVLAQRLNLSAAILTMHIRKLEAAELIETKMVRKEGGTHKMCMLKESAVEIQLPSPGSSDGNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE25</accession>
    <name>A0A398CE25_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_11525</name>
        <name evidence="3" type="ORF">D3H35_25955</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000044">
        <property type="protein sequence ID" value="RIE00880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00880">
        <property type="protein sequence ID" value="RIE00880"/>
        <property type="gene ID" value="D3H35_25955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03311">
        <property type="protein sequence ID" value="RIE03311"/>
        <property type="gene ID" value="D3H35_11525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="197" mass="22084" checksum="A4DDEA88963FB346" modified="2018-12-05" version="1">MSPSPWLSIVLFGIVIFGYAWMMPRRQSNAQDRESANEAAYDKLLEDLELENRELVDAVAKFKREQDETVERLGRRVRDMEQQMRSWSEQRTSTASPPSSTEAPTVTERIETESASAIAVPFAAVMSAAETASYPVPEPAETEPAAAATTIRVRYAELLEQHARGRSVEQIARSFGMNKGEVQLILQLARREEEPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE82</accession>
    <name>A0A398CE82_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spore gernimation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_24340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01486">
        <property type="protein sequence ID" value="RIE01486"/>
        <property type="gene ID" value="D3H35_24340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004761">
        <property type="entry name" value="Spore_GerAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34975">
        <property type="entry name" value="PTHR34975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03845">
        <property type="entry name" value="Spore_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00912">
        <property type="entry name" value="2A0309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="427" mass="46986" checksum="2DBAA34ABF597A2D" modified="2018-12-05" version="1">MRSGSHYPPKEWYLVPLMRARLHLICTSMNDFPCGRHTTPDTSISPTGGPSLGENKLAQLLCLVVLFQIGSTPLDLLAKGAGHDAWISVLVGMACGLLLLLLVFLPLHRLQPDGTLVDMLLRHFGKAIGGLVAAAYVVFFAYRALRNVRDFGELLNMNLYSETPLAVTMLVLTATAAFTVYKGIEVLGRMVEVLVPWTIVGYLFLFALIIGTGLLDFNRLLPLLEEGWKPVWSAVPGVISLPFSEMVLFLMFWNHAGRSYSAIVKWSTLGFVVNGLFITITNSVILAGLGPMAETAELPFLQLTNRIMIGGLFERMDPVISLLLFTGVFVKITAYYLGAVCALSRLFNKKERLFLLPVGLAIYAGSFLFHSYMEEVRVGAGINAMLHFPIFQIVIPVVLLAWIGIKLSLRRLGSRPSGPERQMGGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEB7</accession>
    <name>A0A398CEB7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01516">
        <property type="protein sequence ID" value="RIE01516"/>
        <property type="gene ID" value="D3H35_24495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="159" mass="17527" checksum="D62EEE20276671A1" modified="2018-12-05" version="1">MVPFKKINSAKVNAEQPLVNAGSSLSLVRPLQDFLKDDKYVSEINEATVVEINGKLLLKLVVTVTDKDDYEQTETFLLKPDYRHPSSSYFKLLEVTGCMPGRGESLDVDSLVGQEVILSLKTVTKNGNVYTNIDNVEAVPDEEAVTEEADGSETVESEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEM4</accession>
    <name>A0A398CEM4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_17950</name>
        <name evidence="2" type="ORF">D3H35_29280</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000059">
        <property type="protein sequence ID" value="RIE00312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00312">
        <property type="protein sequence ID" value="RIE00312"/>
        <property type="gene ID" value="D3H35_29280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02569">
        <property type="protein sequence ID" value="RIE02569"/>
        <property type="gene ID" value="D3H35_17950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="162" mass="18480" checksum="EA43F99F1E519FD5" modified="2018-12-05" version="1">MTLFLGAILSFVFFSSSYSKITNIKNFQMEIASYGIHFIWIPIISWAILIFEIGLSVVFLSNDTMENWKQVLAIAFIILLSVFTIIKNGIKNNQCSCFGINHPLSRFPVQRNAVVLLLLIIDFFLPNETTPLHLSISSVLVVLCVTFILENIKLKNELFEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF76</accession>
    <name>A0A398CF76_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01230">
        <property type="protein sequence ID" value="RIE01230"/>
        <property type="gene ID" value="D3H35_22820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="289" mass="31845" checksum="117C4C4BC619441A" modified="2018-12-05" version="1">MNEKLTNYLNGVFASYDGVTSVTELKNDLLSDLQERFRELKAEGKDDETAFEMTIESIGDIDQTIQEVANLSRSLERQVRINLRAIDLQESDFAGVILHKGEFKAAALRGADFAGADLTGTSFANSNVREANFDGANLTDCSFSVTDLTDASFNKSILVRTNFSISGLDGAKFTDAKLTDVTLTKTDLKKTIFNRCIFTGVDFKNSDLRGMSFDGQTFIGVKFDKSALNDVSFRGATLKNVSFRLPFSMTNKSYLSFKTVCFDGATMDKLTYAALKGLWVVDLSKVTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF95</accession>
    <name>A0A398CF95_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">def</name>
        <name evidence="4" type="ORF">D3H35_03570</name>
        <name evidence="3" type="ORF">D3H35_13855</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000022">
        <property type="protein sequence ID" value="RIE04917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01866">
        <property type="protein sequence ID" value="RIE01866"/>
        <property type="gene ID" value="D3H35_13855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04917">
        <property type="protein sequence ID" value="RIE04917"/>
        <property type="gene ID" value="D3H35_03570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="172" mass="19082" checksum="502AEFBF0946E825" modified="2018-12-05" version="1">MSVKTILPFGESILRKKAKPVDAVTPKIIQLLDDMAETLYATDGRAGLAAPQVGILRRVIVMDCGDGLIELINPRIVERSGEQTGAEACLSFPGFYGHVLRSNYVKIESLNRAGETFELEGEGFLARCIQHEIDHLEGILFIDHVQTPWLFHEQTQERIGLLDVVKLSNQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFC3</accession>
    <name>A0A398CFC3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD-GYP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_11140</name>
        <name evidence="2" type="ORF">D3H35_23955</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01423">
        <property type="protein sequence ID" value="RIE01423"/>
        <property type="gene ID" value="D3H35_23955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03581">
        <property type="protein sequence ID" value="RIE03581"/>
        <property type="gene ID" value="D3H35_11140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="1">
        <location>
            <begin position="119"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="359" mass="40399" checksum="D222697EC497797E" modified="2018-12-05" version="1">MPIIPTSQVQAGDRLGSDVQTALGSILLQKGRALSERDLEILQAYLIASVEVSRSGLDENEMDLPADELAANASDIKQTPLQQQFVHMELLLKRVFSMVQSGLKIPVLDVRNGLSALLSRIDEYNILTFYLPPSEGKTDVLIRNSVLCAMTSYTLAKWNKFPEKDLFPIAMAGLLHDIGNTKVDSAVLHKPSRLTNDEMLEMRQHTLHGFRLLENVTSLNQGIWLSALQHHERIDGSGYPMKLKGDKIHPYAKIVAIADMYHAMTSNRHYRKAESPYLVLEELHAGSFGKLDPVYVQTFIERTTQFHNGLFVRLNDGRLGEIVFSDRNHPTRPMVSIHGQIVNLAQDRKLFICEVFTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFH5</accession>
    <name>A0A398CFH5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00652">
        <property type="protein sequence ID" value="RIE00652"/>
        <property type="gene ID" value="D3H35_27185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="76" mass="8823" checksum="FCF313DB5B777BAA" modified="2018-12-05" version="1">MISEEMLDKYRVEGTKVRVIRDALVQNDVVGIVVAWDDEFFLVRRPNRRVVKLGRGYKLQPADEPRPESEAILPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFN7</accession>
    <name>A0A398CFN7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADH-quinone oxidoreductase subunit L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_14665</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02006">
        <property type="protein sequence ID" value="RIE02006"/>
        <property type="gene ID" value="D3H35_14665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="10">
        <location>
            <begin position="69"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="9">
        <location>
            <begin position="135"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE02006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="624" mass="66923" checksum="C9118994E4068599" modified="2018-12-05" version="1">MSSFAQYAWLVPVFPLASFAVLTALGRGARMTGAWIGTLGTLLSLALSLCIVSERLGGTAEDYRSGIDWLRVGGLTLGAGFEVTNLTSLMLVVVSLVSFLVNVYSQGYMKDDERISTFFAYVALFTSSMLGLVLADNLLTLYVFWELVGVCSFLLVGFWFHKPEAKAAAKKAFIVTRIGDLGLLIAVLLLFWYMPDHALDFASIHNVFDTQSGVISTGITTLIALLIFLGAVGKSGQFPLHVWLPDAMEGPTPISALIHAATMVAAGVFLVARTFDIFDASQVAMNTVAIVGAFTAIFAATIGLVQNDIKRVLAYSTVSQLGYMMLALGVGSVTGAMFHLFTHAFFKALLFLGAGSVIHGVHTQDIREMGGVGRKMKVTAWTFGIGALALSGIPPLSGFWSKDAVLTAALDGGHPLLFVVGAVAAFFTALYMARLFFLVFTGSPRSDSASRAHESPDVMTLPLLVLAVLAIASGFVETPWKGWFGEWLTGAAPDEHTNVLVIVVSVAVGLLGLYLGWLIYGKGSVSRDVFSSKAPGIVALIERKYYIDELYRYLFVKPLQGLGKALHAFDDYVVDGAVRLAGYSVSTLGRLNTRLQNGQLQAYALTALIGLVILALAIAGRRFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG47</accession>
    <name>A0A398CG47_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease P protein component</fullName>
            <shortName evidence="6">RNase P protein</shortName>
            <shortName evidence="6">RNaseP protein</shortName>
            <ecNumber evidence="6">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnpA</name>
        <name evidence="8" type="ORF">D3H35_24015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RnpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01435">
        <property type="protein sequence ID" value="RIE01435"/>
        <property type="gene ID" value="D3H35_24015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020539">
        <property type="entry name" value="RNase_P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33992">
        <property type="entry name" value="PTHR33992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00648">
        <property type="entry name" value="RIBONUCLEASE_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="140" mass="16071" checksum="3E80602F4F66DC96" modified="2018-12-05" version="1">MERKLRLRRREDFNKVYRHGKSFANSQFVVYWRKRSDPVCFRLGVSVSSKLGGAVVRNRMKRMVKEIVRLNESKLHPEYDLILIVRKPALAMVYKELEGSVMHVLRKAGLLKGSPPFSGTRNPPSTRGGNQRSGSSNRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGA3</accession>
    <name>A0A398CGA3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA sulfur modification protein DndE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dndE</name>
        <name evidence="1" type="ORF">D3H35_24570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01530">
        <property type="protein sequence ID" value="RIE01530"/>
        <property type="gene ID" value="D3H35_24570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014969">
        <property type="entry name" value="DNA_S_DndE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038472">
        <property type="entry name" value="DndE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08870">
        <property type="entry name" value="DndE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03184">
        <property type="entry name" value="DNA_S_dndE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="138" mass="15709" checksum="C5991BDA33FA0B4C" modified="2018-12-05" version="1">MIIKQITLSNHAKDQLSRLKGKTGIQNWNVLCRWAVCLSLREPTVPMEMVIPSDSNVEMSWHVFGGDHHEIFEALIIQRCINDNLGTDPATLSKYFRLHLHRGISYLSSSNLIKSIEDLLTLATENTLFLKEEAGNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGD7</accession>
    <name>A0A398CGD7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_16310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02286">
        <property type="protein sequence ID" value="RIE02286"/>
        <property type="gene ID" value="D3H35_16310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017486225" evidence="2">
        <location>
            <begin position="25"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="238" mass="24648" checksum="2077F33E4CDCBF9C" modified="2018-12-05" version="1">MKKHVRIMALTGALALMIPLSAYAATSGTAAKTEKANAPIAQQGGRGGDHGREAVSQTVLDLLKLDAAAFKAKAEEGKTLAQIAEEQGVSRDSLKQALTDDFTKKQAEEKTRFANNLDNQLDGKLNAGKGGAFGLKNTVTSAEAATILGLTEAQLKTELSAGKSLADIAKEKGVDSQKLIDVQKAAIVKSINEALAAGKLTQEQADKRLAEAAADAENIVNGKGFKGNGGGKGHRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGX9</accession>
    <name>A0A398CGX9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit I</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">nuoI</name>
        <name evidence="8" type="ORF">D3H35_14650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02003">
        <property type="protein sequence ID" value="RIE02003"/>
        <property type="gene ID" value="D3H35_14650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="149" mass="16637" checksum="B9DDF8ED62324B1E" modified="2018-12-05" version="1">MKGMLKGLGVTLKTMGAKKVTMSYPDVPIDMPDRFRGIQYFEPDKCIVCNQCVRICPTECISLTGKPNPDPAKKGKVIDTYDINFEICILCDLCTEVCPTEAIVMTNNFELAAYSRDELFKDKDWLYSNDKKVRSDNNPIGAPQKGGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH40</accession>
    <name>A0A398CH40_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_14970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial flagellin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02063">
        <property type="protein sequence ID" value="RIE02063"/>
        <property type="gene ID" value="D3H35_14970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042187">
        <property type="entry name" value="Flagellin_C_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00207">
        <property type="entry name" value="FLAGELLIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flagellin_N" evidence="4">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="5">
        <location>
            <begin position="191"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="276" mass="29559" checksum="FBEE0EECB68DE4E6" modified="2018-12-05" version="1">MIINHNLPALNTHRNLGINTNATSKSMEKLSSGLRINRAGDDAAGLAISEKMRAQIRGLDQASRNAQDGISLIQTAEGALSETHSILQRMRELAVQASNDTYTTADRAKLGAEVTQLTKEINRIASQTEFNTKKLLISGGGASAINFQVGANSGQQIQLSINKMDTSSLGVSAFGSQFSANTSTAFGSIIAAINSAINKVSSERANLGAYQNRLEHTINNLNTSSENLTAAESRIRDVDMAKEMMNFTKNNILNQAAQAMLAQANQLPQGVLQLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHG7</accession>
    <name>A0A398CHG7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00358">
        <property type="protein sequence ID" value="RIE00358"/>
        <property type="gene ID" value="D3H35_28460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="60"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="301" mass="32640" checksum="1A5B7F032A454A74" modified="2018-12-05" version="1">MTELKIGMVGLDTSHCSTFAALLNDPSHPNHVPGGRLLYGFPGGSPDFELSRSRMEGITKSLREERGVEMLDSIEEVARRSDAILLTSVDGRVHKEQFAKLAPYGKPIFIDKPFATSSADAKEIVELAERSGSRFFTCSMLRFGGPLLEALGDDRHGSVVGADCSGPLELEPTQPGFFWYGIHAAEMLYAALGEGCRTVRATRTEGHESVVGVWEDGRIGTIRGIREGNPDFYAVLHRERGSVGVNALGDSYNAGNERLLKHLLTMAGGAPAPVRPSLSLEIVRFIEAANESRESGEVVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHI2</accession>
    <name>A0A398CHI2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multi antimicrobial extrusion protein MatE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00559">
        <property type="protein sequence ID" value="RIE00559"/>
        <property type="gene ID" value="D3H35_27870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="443" mass="48912" checksum="988280FDAB83E571" modified="2018-12-05" version="1">MPTSQEPVTLKKLFLFFIPMGLSVVLINLSHVIINGTLARSANPEMIIAGYALGMSLLTVSERPAVLLRQTCSALVRDQLSYKAVLHIGYYVFGASLVLGALIAYSPLGHLIFGIAYGASADVEKEAIGVFRVLMFLTVFSGLRCFFQGVIIYKMRTRWLTIGMIFRLAGMFAVSQYFIQTGVSSAAQGSMIFVVGMIIEAALSWWECRKLVREMPKEAPDCEIKRPKQVLFFYKPLLYSSLVVVWIMPILNTLLGTTNKATLAVASFSIASSLMNLILGFFTYFHQISLLFIKSDPAQVRKFTLMLGFVPAALIIAVGFTPATPWLLAHVLGVKNELLEASVHAFRSFLPFVLVFPWLDTLNGIVMANGETKLMFASQTANAVVTILVMIVLAILLPSWNGSLGSHALSGGIIAELSVLFWLYRRNLKHKLTVPPSMRELQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHN7</accession>
    <name>A0A398CHN7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="8">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">trpS</name>
        <name evidence="10" type="ORF">D3H35_19065</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02746">
        <property type="protein sequence ID" value="RIE02746"/>
        <property type="gene ID" value="D3H35_19065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="12"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="194"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="19"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="146"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="194"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE02746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="331" mass="36356" checksum="EE8149931C4D85AC" modified="2018-12-05" version="1">MTKQRVLSGIQPSGKLTLGNYIGAMRNFVALQHEHECFFMVVDLHAITVPQEPAALREQSEAVAALFVAAGIDPSQASIFMQSHVTQHAELGWLLTTLSYMGELERMTQFKDKSAGKDAIGAGLFVYPSLMAADILLYDANLVPVGDDQKQHLELTRDLAGRFNHRFGETLTIPEPYIPKVGARIMSLDDASKKMSKSNPNVGSYIALLDSPDDIRKKISRAKTDLGREVEYDPQNKPEISNLMSIFAQCTGQSLEDIRQAYEGQGYGAFKKDLAEAVVAALEPIQSKYADIRSSGAIHDILKDGAVRAREVAEATLSRVKDAMGFLPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHQ9</accession>
    <name>A0A398CHQ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02323">
        <property type="protein sequence ID" value="RIE02323"/>
        <property type="gene ID" value="D3H35_16525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="105" mass="12126" checksum="A171B16C6A2C951B" modified="2018-12-05" version="1">MGFQTEFNSVCKFKSEQELYELLEYGRGKMVKKQFRVFPTGQKVIAYSPDNKAVAIVKILASIAEINFQGEEVTQVEMELVRKLTEEESRVQTALAYEMFFGEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHT9</accession>
    <name>A0A398CHT9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02816">
        <property type="protein sequence ID" value="RIE02816"/>
        <property type="gene ID" value="D3H35_19475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="199" mass="23007" checksum="74C0D7DFF1A8C554" modified="2018-12-05" version="1">MSTKLLILGLLMERDRHPYEIRQVIRERNWNVVFLIRDGSLYYAVDQMRDDGMIEAAEVIPVPGDNRPDKTVYRITEKGKAAFLKLLHAQFEQTAYPQHPFFPALPFVRHGDSQKVAESAAKQLEACECRIERMNAVLELKQQYLPRGSIHLMRGIIRFSEAERDWLKDVLADAESGGLEDAGMSFELLLKMQDEWKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHZ8</accession>
    <name>A0A398CHZ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00769">
        <property type="protein sequence ID" value="RIE00769"/>
        <property type="gene ID" value="D3H35_26620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="273"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="319" mass="36451" checksum="9A78BF353F1190E9" modified="2018-12-05" version="1">MNSIETWNERLQAARRDMELGAKWNRRLENLNAEIARQQRAVDANLRRLAEEQEDVERLTSSSFSQFFLGLFGRLEEKLSKEEKEAAEAKLKYDASHEALQGMERERTELLRQLAEVGEAEADYRTLIAEKERWIQAHDTQTAESLERLSEKSGKMKAMLVELAEAVRAGSKVLGSLEGARKMLSSAKSWGTYDMVGGGVIASAVKHGKIDDARKYIHAAQNDLRIFRKELADLNWNLDSDTARMDGLLTFADFFFDGLLVDWMVQGKIKNSLESVDSQLGDVERLLDRLKQEERRLGAESVELEERHRETVENYVRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIH1</accession>
    <name>A0A398CIH1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03086">
        <property type="protein sequence ID" value="RIE03086"/>
        <property type="gene ID" value="D3H35_21120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="96" mass="10298" checksum="B9D6D164DB658D6E" modified="2018-12-05" version="1">MQTVQFGEGSSSYIVSQDGGIVYGPTMEAGHKIFVRAAGESRTATIKENDQEMLSTARTMDTSDWTLLGNIPVSSLVKDAKAISNLTWLMSLLAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIL7</accession>
    <name>A0A398CIL7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2508 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01039">
        <property type="protein sequence ID" value="RIE01039"/>
        <property type="gene ID" value="D3H35_21605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019644">
        <property type="entry name" value="DUF2508"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10704">
        <property type="entry name" value="DUF2508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="86" mass="10195" checksum="E433AF341D469CBD" modified="2018-12-05" version="1">MRWAKKSVWTLVQSEERQQLTEDVREAEREWELARWRFEDALGHDSVDYAIYTLEAAEKKLDMLLRKAKVEWVAEVSGVKSRGKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIR6</accession>
    <name>A0A398CIR6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_16240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02275">
        <property type="protein sequence ID" value="RIE02275"/>
        <property type="gene ID" value="D3H35_16240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018309">
        <property type="entry name" value="Tscrpt_reg_PadR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10400">
        <property type="entry name" value="Vir_act_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="8"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Vir_act_alpha_C" evidence="2">
        <location>
            <begin position="89"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="190" mass="21584" checksum="966C3AF8299557F5" modified="2018-12-05" version="1">MNTLSYGLLSLLSLNPQSGYDLMHRIQPFWPAKHSQIYPLLSCLEKEGLVQFETVAQTDKPDKKVYSVTESGRDALRKWLSEPTDAPALRDALMLKIFCISLSNPDAARALIEERAGYYRCKLDIFKEKLETIREKASLEEEDAPVFGSPYFGSYVLVQRALSSSRSDLNWCEWVVSLLPPGKKPETEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJW7</accession>
    <name>A0A398CJW7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP2_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00177">
        <property type="protein sequence ID" value="RIE00177"/>
        <property type="gene ID" value="D3H35_29490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025559">
        <property type="entry name" value="Eis_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13530">
        <property type="entry name" value="SCP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2_2" evidence="1">
        <location>
            <begin position="7"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="118" mass="13190" checksum="6AAE970970AED203" modified="2018-12-05" version="1">MSRIVDVERFIEPYSFAASEREDVLAIRVEDERADWNDGWFRLTIPANGRSALVERTEMAAPGIPSAACDIQTWTAMLAGGRRPAAFASVGRLKAEEEALAIMERRIPRGPTYLADFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK86</accession>
    <name>A0A398CK86_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UbiD family decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02765">
        <property type="protein sequence ID" value="RIE02765"/>
        <property type="gene ID" value="D3H35_19185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="593" mass="66358" checksum="668862E1DC716B2F" modified="2018-12-05" version="1">MSFSSLRPFLDTLRRDGDLAVIEAPVDPVLELAEIHRRVIEQEGPALLFTNVKGSPFPIATNMFGTSRRVDLAFGPRPEAFMKQLTGALDRVLPPTPKALWGERNLVWDLLKVGMKEVPKDGAPILQVLKRERPLADLPAITSWQEDGGPFVTLPLVYTEHPNNRKHHNLGMYRMQVFDDSTTGMHWQIHKGGGFHYHEAEKRGEALPVSVFLGGPPALIASAIAPVPEMLGELLLASLIIGGKLPMVQNPQGGHRMPAEAEFVISGSVPPFLRRPEGPFGDHFGYYSLTHDFPVFNVNHMWHRKDAIYPATIVGKPRQEDYYLGEYLQRLLSPAFPKVMPGVKELWAYAETGVHALAAAVVREAYSREALTTGFRVLGEGQLSLTKFLMLTDQPVDLARFGDLMERVLERFEPHKDLFVFDETSHDTLDYTSGKLNHGSKAIMMGVGEPVRELPAVYNEGVIEGIHAAKPYCRGCLVVSGASYEADPQLASRVLERLSARGTEWPLVIVADDANIADGQTSFLWTVFTRFNPADDIYANSDIRRHHFGYKLPIVIDARMKPGYPDELFAREDIVELVDRRWKEYFSSSSWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKF7</accession>
    <name>A0A398CKF7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-layer homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_19645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02845">
        <property type="protein sequence ID" value="RIE02845"/>
        <property type="gene ID" value="D3H35_19645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017477053" evidence="2">
        <location>
            <begin position="33"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="70"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="207"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="417" mass="45003" checksum="5DDC3313D6A9EBA8" modified="2018-12-05" version="1">MTQKSTLLKKTAAATLALTMLAGTGTAVMASAHSNNDKKHYSDNGKSKNDKNDKNDKNDKNNNKSGAKINLEFGDLSEKEWKWAYQHIIRLASQGVFSGYEDGSFKPRNNISRIEAIVAAVRFLGLQSEAEKPENMNAKLNFKDFDQFKKKSAWAVGYVTVALENDLFSESATTIDANKPADRLWASILLVKAMKLEALAKTKMDAELPFRDADKIPAGSVGYVAVAVEKGWVSGYTDKTFQPNKPITRAELASILDIVDQQQPDTSAQAITGTIQAVANGSITIKKPDNTTVTVALDSNVFIFRKDVKSPVSALVAGDEALVRTYQNKVVFIEVTKPAEAAVQLVDTGKVGSFTLNAQGKIATISLTKEVNGTSQTIVYNVDGNVAITGSSGVLAPNLNVIVKGENNVVKTIQILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKX4</accession>
    <name>A0A398CKX4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_24670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01548">
        <property type="protein sequence ID" value="RIE01548"/>
        <property type="gene ID" value="D3H35_24670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="139"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="139"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="238" mass="26960" checksum="FC00528883DE8E06" modified="2018-12-05" version="1">MTKRKVLIVEDDQAIAELERDYLEVHGYEVTLRADGRQAMEEALEQAYDLIILDVMLPGMDGFDILRRIRETKFIPVLMVSARKEDIDKIRGLGLGADDYVTKPFSPSELVARVKAHLERYDRLTGAAAGAGTLSVRKIRELNIRGLAIQVDARRVTLNGQEITMTAKEFDLLLFLAENPDRVYSKEELLDKVWGIDNFGDSATVTVHVGKIRDKIQKDPAKHQFIETVWGAGYRFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL98</accession>
    <name>A0A398CL98_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SRPBCC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_20535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02992">
        <property type="protein sequence ID" value="RIE02992"/>
        <property type="gene ID" value="D3H35_20535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="135" mass="15293" checksum="C60276890F84FDF5" modified="2018-12-05" version="1">MGRIQWKTFSVTIERGTEEVYEYIMNPENFAEWAISFCRSVKKTDSGWSIETAEGPMSLRFADGNPYGIMDHYVRAGAGNEKPNPARVIPDASGSKVIFTVFQAEDEADREYATTFRNVEEDLLALKSVLEKRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLA5</accession>
    <name>A0A398CLA5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_28845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00421">
        <property type="protein sequence ID" value="RIE00421"/>
        <property type="gene ID" value="D3H35_28845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="126"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE00421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="231" mass="26119" checksum="9EBCAF02F6EC3CBA" modified="2018-12-05" version="1">MNHILLVEDDVNFVFGIEYTLSSEGYTVTLAGSLEEARKVFANGSIDLILLDVNLPDGSGYELCKEIRVSSQVPIIFLTALDEEIHVVAGLDLGADDYMTKPIRIKELLSRMNAVWRRNNKSIEEVKLWKSGDIQVRVLEGTVFKNNSEVILTALEYRLMLMLITHSNQVCSRGALLHHLWDMSGEFVDDNTLSVHIRRLREKVEDEPAAPQYIITVRGVGYKWNAEVSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLB6</accession>
    <name>A0A398CLB6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00431">
        <property type="protein sequence ID" value="RIE00431"/>
        <property type="gene ID" value="D3H35_28905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="252" mass="28106" checksum="3ADB1D0097E941E8" modified="2018-12-05" version="1">MNAVRSKKLVVFIPAHNEEGDIGDVISRIPRDFHPEYAVQVVVIDDGSTDGTVAVAKKAGADLVVSFGTNRGLGAAVREGLAQSCSLGADIGLMIDADNEYPPEQIPDVVAPIREGEADYTFGSRFKGRIHGMRLHRRLGNYAFTLLQSILLRKWIYDGQSGMRGFSREAMERAEIIHDYNYAQVLTLNLVRKGFRLREVPIDYRVRTRGQSFIKMRAYLSAVLPAICREMRRPAGSRKVPNRSGKIQETLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLC0</accession>
    <name>A0A398CLC0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_19995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03215">
        <property type="protein sequence ID" value="RIE03215"/>
        <property type="gene ID" value="D3H35_19995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="134"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="349" mass="38248" checksum="BE21FBA91610C8D3" modified="2018-12-05" version="1">MIGCGGIAMGKHLPALAKIPEAQVTAFFDVAYERGEEAKSKYGTHDARVYTNVHELLNDPNVHVVHVCTPNDTHAEISIAAMEAGKHVLCEKPMAKTAIDAQRMLDTSERTGRKLSIAYQNRFRRECLWLNEACRNGELGEIYLAKAHAVRRRAVPTWGVFLDLEKQGGGPLIDIGTHALDLALWFMNNYEPKTVLGTSYRKLAEQGSKANEWGPWDPSKFTVEDSAFAMITMKSGATVWLESSWALNTLDVDEAKVSLSGTKAGADMKGGLRVNGEEHGRLYTKEVQLGSAWGGDVPNDAAEQEARAWIHAILNDESPVVTAKQGLVVQQILEAVYESANKGQAISFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLI6</accession>
    <name>A0A398CLI6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5018 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_13040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01728">
        <property type="protein sequence ID" value="RIE01728"/>
        <property type="gene ID" value="D3H35_13040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032186">
        <property type="entry name" value="DUF5018"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16410">
        <property type="entry name" value="DUF5018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017252524" description="DUF5018 domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5018" evidence="2">
        <location>
            <begin position="30"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="121" mass="12988" checksum="141F08311CED61BF" modified="2018-12-05" version="1">MLRTFKKAASAALVLCLFLSVFPQVIFANVESSSKEFLSFSVEGNPGIIDNELHTISVVVPFRSAVNNMLETFTVSEGASVLNHTSDVTRTNYSSPVALTVVAENNSTQVYTVTVTIGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLL6</accession>
    <name>A0A398CLL6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_13160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01748">
        <property type="protein sequence ID" value="RIE01748"/>
        <property type="gene ID" value="D3H35_13160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="214" mass="25902" checksum="DC77EF87659C2B9C" modified="2018-12-05" version="1">MGWRPIVERLHNKFAQRVGRRPIVECQNNKFAKRMGWRPIVECLHNKFAQRVGWRPIVERLDNKFAQRVGWRPIVECQNNKFAKRVGWRPIVERLHNKFAQRVGRRPIVECQNNKFAKRVGWRPIVERLDNKFAQRVGWRPIVERLDNKFAKRVGWRPIVERQNNKFAERVGRRPIVERQNNKFAKRMGWRPIVERLHNKFAKRVGWRPIATRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLM0</accession>
    <name>A0A398CLM0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dtd</name>
        <name evidence="2" type="ORF">D3H35_27765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00541">
        <property type="protein sequence ID" value="RIE00541"/>
        <property type="gene ID" value="D3H35_27765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00563">
        <property type="entry name" value="Dtyr_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="147" mass="16091" checksum="06E0EF3E6695262F" modified="2018-12-05" version="1">MKVVVQRVSQARVTVEENVVGEIGYGLLLLVGIGHEDGDADLAWMADKLAGLRIFEDEDGKMNLSVVDSKGAILSVSQFTLYGDVRKGKRPNFMAAARPEQAEALYERFNAMLRERGLQVETGRFGTMMDVSLVNDGPVTLIVDSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLU7</accession>
    <name>A0A398CLU7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="11">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">alaS</name>
        <name evidence="14" type="ORF">D3H35_21045</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="11"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03230">
        <property type="protein sequence ID" value="RIE03230"/>
        <property type="gene ID" value="D3H35_21045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="13">
        <location>
            <begin position="1"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="730"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="562"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="566"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="664"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="668"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE03230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="877" mass="95271" checksum="01A268E5433213E8" modified="2018-12-05" version="1">MKAADIRAKWLEFFASKGHQIEPSSSLVPHNDPSLLWINAGMAPLKAYFDGRVKPENPRIANSQKCIRTNDIENVGKTRRHHTFFEMLGNFSIGDYFKEEAIEWAWEFLTGPQWIGFDPDRLSVTVYPDDEEAFRYWNEKIGLPAERIYKLEDNFWDIGEGPCGPCTEIFYDRGDKYGDLSDPECTPGGENERFLEVWNLVFSQFNHNKDGSYTPLPNKNIDTGAGLERFASIVQDVDSNFDTDLFMPIIERASAIAGVKYKEREDYDVALKVVADHIRTVAFSAGDGVLPSNEGRGYVIRRLLRRAVRYGKVLGIDRPFLWELTSTVGEVMGSYYPEVVEKREFIEKVIRTEEEQFHKTLGEGLSILAELCDKAKAAGSTEISGPDAFKLYDTFGFPFDLTEDYAAEQGMTVDRAGFDASMEEQRERARTARKDVGSMKVQGGVLSEYTDKSEFVGYDALAAEAKVLAIVVGDSFADSAGADETVLVVLDRTPFYAESGGQVSDRGTLQGAAVLATVDGLSKAPHGQHLHQVTVTGGTLQVGDTVTATVNPAERADIVRNHTATHLLHKALKEVLGEHVNQAGSLVDPDKLRFDFSHFGAVTAEELADVERRVNEQIWLGTELDISFKPIAEAKALGAMALFGEKYGDIVRVVKVGDYSLELCGGCHVRNTEQIGLFKLVSEGGIGSGVRRIEALTGRHAYAYLDEQFATLKEAAALLKCGAADVPKRVEAAQGDIRQLQRDVESLQGKLSRLEAADLAGSAKTVGGVTLLAAQVNATGMDALRGVADELKAKLGSAVLALGAIDGDKVNLIVAVTSDLTSKGLHAGKMVKELAAICGGGGGGKPELAQAGGKEPSKLAEALAAAEQLVLAQTASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLX6</accession>
    <name>A0A398CLX6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arsenate reductase (Thioredoxin)</fullName>
            <ecNumber evidence="7">1.20.4.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">arsC</name>
        <name evidence="7" type="ORF">D3H35_12360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.20.4.4" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03445">
        <property type="protein sequence ID" value="RIE03445"/>
        <property type="gene ID" value="D3H35_12360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030612">
        <property type="term" value="F:arsenate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014064">
        <property type="entry name" value="Arsenate_reductase_ArsC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02691">
        <property type="entry name" value="arsC_pI258_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="6">
        <location>
            <begin position="5"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="141" mass="15594" checksum="A3664F4927A4C1CB" modified="2018-12-05" version="1">MVNKPLIYFLCTGNSCRSQIADGFMKALGSDWYEVKSAGLEAHGLNPRAVQVMQEAGIDISGHSSDVIDPELLNRAAYVITLCGHADEHCPVITNVNVIKYHWGFDDPAKATGTEHEIISQFRHVRDAIKARIELFLLDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM33</accession>
    <name>A0A398CM33_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_10425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03703">
        <property type="protein sequence ID" value="RIE03703"/>
        <property type="gene ID" value="D3H35_10425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="69"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="163" mass="17752" checksum="CAA44EB556610B02" modified="2018-12-05" version="1">MDGHSVRNRGSDSRHSPAGARASPAGAGRAWSRQRAVRDGDPLSGRRRSRCRRKDSRLPRLHAAAETAVYRIVQEALTNAIRHGEANGCIVRLFEDKGVARIEIDDDGRGVPEPYVPGIGIRSMKERAEELGGSFRLRTIPGQGTSVQVTIPCGREEMDDGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMA1</accession>
    <name>A0A398CMA1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_21315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE00997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00997">
        <property type="protein sequence ID" value="RIE00997"/>
        <property type="gene ID" value="D3H35_21315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="84" mass="9240" checksum="3A3804153EA9CA52" modified="2018-12-05" version="1" fragment="single">GISRSFRHDRHMSKLIDDIASQTQLLALNANIEAARAGDHGTGFASFAKRYPSSRCKPGIRRPHHRTDDSSDARSAVLRKPSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMA2</accession>
    <name>A0A398CMA2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03380">
        <property type="protein sequence ID" value="RIE03380"/>
        <property type="gene ID" value="D3H35_11930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="207" mass="24168" checksum="9C798BE66E2C9433" modified="2018-12-05" version="1">MDEAKRGAILNISYLFSSQPVLETERLILRRLQPADANEYFHFASDPLIATHTMWSFHETVEDTKAYLDKLENKYEQKTAYHWAIHNKQNRLVVGRTGFIRFDHTHDSTEIGFVVSREYWKQGIMTEATRAIIEYGFEELGVNRIESRCNEDNIGSERVMQKLDMNFEGILREQLKIKGEYVNQKMYAILKRDFEGHRASLSGKGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMB0</accession>
    <name>A0A398CMB0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 11">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2 8 11">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pgk</name>
        <name evidence="13" type="ORF">D3H35_21370</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 11">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 11">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2 8 11"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01007">
        <property type="protein sequence ID" value="RIE01007"/>
        <property type="gene ID" value="D3H35_21370"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="8 9">
        <location>
            <begin position="21"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 9">
        <location>
            <begin position="59"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <begin position="349"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE01007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="393" mass="41914" checksum="5CB03E82CD8DB5C4" modified="2018-12-05" version="1">MNKKSVRDVELAGKKVFVRVDFNVPLENGAITDDTRIRETLPTIKFLIENGAKVILASHLGRPNGEVVEGLRLTPVAARLSELLGKPVVKADEAIGESVKGLVAALKDGDVLLLENVRFYAGEEKNDVELAKAFAELADLYVNDAFGAAHRAHASTEGIAHHLPAVSGLLMEKELDVLGKALNNPERPFTAIVGGSKVKDKIDVINKMIEIADNILIGGGLSYTFFKAQGYEIGQSLCDNSKLDLTLEFIEKAKKAGKNLLLPVDIVISDDFSATANTNIVGLDGIPSDWEGIDIGPKTREIYADVIKNSKLVVWNGPMGVFEIEPFSHGTRAVAQACADTSAYTVIGGGDSAAAAEKFHLADKMDHISTGGGASLEFMEGKALPGVVALNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMC7</accession>
    <name>A0A398CMC7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">ATP phosphoribosyltransferase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hisZ</name>
        <name evidence="8" type="ORF">D3H35_21485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heteromultimer composed of HisG and HisZ subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01027">
        <property type="protein sequence ID" value="RIE01027"/>
        <property type="gene ID" value="D3H35_21485"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00125">
        <property type="entry name" value="HisZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004517">
        <property type="entry name" value="HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00443">
        <property type="entry name" value="hisZ_biosyn_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="25"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="404" mass="44589" checksum="21F8AE258FB78995" modified="2018-12-05" version="1">MSKPKVFEKPTGVKDYLPHAVAKLRRIERDVLECMRRWGYEQIMTPTLEYYDTVGVASATSDQKLFKLLNHRGTTIVLRSDMTAPIARVVGSLLKEQSFPLRLSYHGNVFRAFEEEAGRDAEFFQTGVELVGDPSPEADAEMIALAIESLKSAGVKSFKIAVGHVGFLNGLFEETLLGRDAEQDALKACLLQRDHVGYRHILRNLSVEDGSKRELEDILRLRGGQEVCEQALQLSGNEEAHKAIRHLCEVWDVLEAYGVQEHVLIDLTMIGDFTYYTGMTFEGYASNMGFPVCSGGRYDNLLAQFGRPAPATGFALKTTRILEVVEDEAASGKGSGKTLIMYTAAARVRALAEAAKLRTEGSAVVAAGVIGEEWPDTVKVEDGFVYQGTLFEHLIVFDGKGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN47</accession>
    <name>A0A398CN47_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04033">
        <property type="protein sequence ID" value="RIE04033"/>
        <property type="gene ID" value="D3H35_08755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="285" mass="30396" checksum="7E421396F3C387DA" modified="2018-12-05" version="1">MSKPSSFPPQHQTVQPGIQAYMNPLPETELPSYTPSGKLKGKVAVVSGGDSGIGRSVSIYFAKEGANVAVLYLNEEADAQETKKQIEAEGRRCFLLSGDIGDPAYCKRAVEETVRTFGRLDIVVNNAAEQHPLDKLEQITPEQLEKTFRTNVFGMFYLTQAALPHLKAGSAIINTTSVTAYRGSPGLLDYSASKGAQVAFTRSLSMNLTGQGIRVNAVAPGPIWTPLIPATFDAQKVAAFGADTPMGRAGQPDEIAPAYVYLAGEDSSYMSGQVLHVNGGEIING</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN61</accession>
    <name>A0A398CN61_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PspA/IM30 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_18640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02679">
        <property type="protein sequence ID" value="RIE02679"/>
        <property type="gene ID" value="D3H35_18640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31088">
        <property type="entry name" value="PTHR31088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="228" mass="25727" checksum="6958E6A3936E1076" modified="2018-12-05" version="1">MGVFQRMKDITKASVHDLLDKLEDPIVMLNQYLRDMETEIRDAEVTVARQMAAERRIKQRLEEAVRLGVERESQAEHALRNGNEAYARKVLEEKLQFAKQADELIGLHGQASAQVNELTAQLHEMKEEYYKLRNKRNELAARAQMAKARKQMAQISSLHTIESGQASHGFHRMEEKIMQLEAEADVVRLPGSPFGAAPASVDPEKAYRVDQELAALKSRIAPPAADGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN74</accession>
    <name>A0A398CN74_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lgt</name>
        <name evidence="4" type="ORF">D3H35_21505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01031">
        <property type="protein sequence ID" value="RIE01031"/>
        <property type="gene ID" value="D3H35_21505"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="360" mass="40151" checksum="6CAE4DD2A933D711" modified="2018-12-05" version="1">MFPLELNPIAFSIGSLPVHWYGIILGSAALVGLLLAIQEGKRFGIVPDFFLDLLLYGVPSAIIGARLYYVLFKWNYYSKHPGEIIQIWNGGIAIYGALLGALICGIIYIRKKGYSVWRIIDVCAPSLLAGQMIGRWGNFVNQEAYGGPVEESFLRDKLHLPDFIVDQMNITGVYHHPTFLYESLWSLVGLALLFIVRRQRFLKAGELFLGYFIWYSIGRFYIEGLRTDSLAFEGPAWLASLVDGLWSPMKVVFDEGFLDPAYGNVRSSQLMAIFIIVVGIALIVIRRRTGQASERYVDPIVRRVNPAVATSETAAAGDAATDSNEKPGAIERENGEQEQAAEKTETSTDELKKENNDRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNC4</accession>
    <name>A0A398CNC4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rieske family ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_28800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00414">
        <property type="protein sequence ID" value="RIE00414"/>
        <property type="gene ID" value="D3H35_28800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012747">
        <property type="entry name" value="MocE_2FeS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02377">
        <property type="entry name" value="MocE_fam_FeS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="8"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="106" mass="12167" checksum="F1B9FDAAAFEB9C1A" modified="2018-12-05" version="1">MTIGQQWIEVCGVDEIEEEDVIRFDHDDLTFAIYRTDTGDFYASDGYCTHEKFHLSNGLVMGKMIECPKHNGRFDIPTGAAKRAPVCVDLKTYPVKIEQDKVYIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNH1</accession>
    <name>A0A398CNH1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Futalosine hydrolase</fullName>
            <shortName evidence="1">FL hydrolase</shortName>
            <ecNumber evidence="1">3.2.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Futalosine nucleosidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Menaquinone biosynthetic enzyme MqnB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mqnB</name>
        <name evidence="4" type="ORF">D3H35_03565</name>
        <name evidence="3" type="ORF">D3H35_13850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>futalosine + H2O = dehypoxanthine futalosine + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:25904"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:58863"/>
            <dbReference type="ChEBI" id="CHEBI:58864"/>
            <dbReference type="EC" id="3.2.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.26" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000022">
        <property type="protein sequence ID" value="RIE04916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01865">
        <property type="protein sequence ID" value="RIE01865"/>
        <property type="gene ID" value="D3H35_13850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04916">
        <property type="protein sequence ID" value="RIE04916"/>
        <property type="gene ID" value="D3H35_03565"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00991">
        <property type="entry name" value="MqnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019963">
        <property type="entry name" value="FL_hydrolase_MqnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03664">
        <property type="entry name" value="fut_nucase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="55"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="237" mass="24531" checksum="98CD5B3271EF91AF" modified="2018-12-05" version="1">MLSENKTRVLIMTAVDAERDAVLRGLGERGDKFDVKSNTGLPESGDRIEFEVELAGVGPALAAARTARALARGRYSLVVSAGIGGGFVERAEVGTLVMASEIVAADLGAETPDGYLSVDELGFGASRIAVESGLAKAWADKLVEQGWTVCSGPILTVSTVTGSAETAFDRAARVVGAAAEGMEGYGVAAAAHDVGVPALEIRSVSNPVGPRDRAAWRIKDALTALEAAFSNFPEVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNI1</accession>
    <name>A0A398CNI1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02288">
        <property type="protein sequence ID" value="RIE02288"/>
        <property type="gene ID" value="D3H35_16320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="319" mass="34147" checksum="24F0DC068238081F" modified="2018-12-05" version="1">MTPDSGQALEIRHLRFLLAAAGERALEIRHSQLLLASDDGGLLEIRHSQLLLASDGGGLLEIRHSQLLLASDDGGALEIRHSQLLWRANGGDSAGIRHSQLLFAANGGRALEIRHSQLLWRANGGDSAGIRHSQLLLAANGERALVIRHSQLLLASDGGRALEIRHLQLLLASDGGRALEIRHSQLLLASDGGDSAGIRHSQLLWRANGGDSAGIRHSQLLFASDGGRALEIRHSQLLFASDGGGALEIRHSQLLLAANGGRALEIRNSQLLWRANGGDSAGIRHSQLLLAANGGRVLEIMHSRFLFAEGATNPRRNPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNQ3</accession>
    <name>A0A398CNQ3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="2">M1Pi</shortName>
            <shortName evidence="2">MTR-1-P isomerase</shortName>
            <ecNumber evidence="2">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">mtnA</name>
        <name evidence="3" type="ORF">D3H35_08355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03962">
        <property type="protein sequence ID" value="RIE03962"/>
        <property type="gene ID" value="D3H35_08355"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="53"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="255"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="352" mass="37694" checksum="DFC6C82ECED53803" modified="2018-12-05" version="1">MTQSISQEVLQSVRWAGESVDLLDQRLLPEETVYLRLTTPHDVWEAIRELKVRGAPAIGIAAAYGVVLGILGFEGNSKELAAEVRNHADYLATSRPTAVNLFWALDRMKAKAAVLAESEAPVSDAIGAMIAEALLIQSEDEETNRLIGEHALTLFEDGMGVLTHCNAGGLATAKYGTALAPFYLALERGISLKVFADETRPVLQGARLTAFELQRAGVDVTLICDNMAGHVMSKGWIQAVIVGTDRVAANGDVANKIGTYSVAVLAKAHGIPFYVACPLSTIDLSTPTGADIPIEERHPDEVTAGFGKRTAPEGIAVYNPAFDITPHEYVTAIITEKGIVKAPFSEGLKKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNR7</accession>
    <name>A0A398CNR7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02368">
        <property type="protein sequence ID" value="RIE02368"/>
        <property type="gene ID" value="D3H35_16775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="362" mass="40914" checksum="A2EDDF2983A816CA" modified="2018-12-05" version="1">MGASMILSEARGEVRRIEDFFSAKLSNKRDLRIYLPPGYSDYTNRRYPVLYMHDGQGLFDPGSFSQASWLVHETADRLIAEGRLEEIIIVGIDNKGDERLHEFTFPLDATGGIPGAPDAECRGTLYERFIIDELKPFIDRSFRTLPDRSHTGMMGSSLGGLVTYHIGFRNPAVFSKLGIVSPHFVRLDLNSLEEFPFYRSYGFNDLKLWIDIGEIEAHILTRHVREVVDELIGEGFIPGFGLAYCEVPDAAHTEHDWAERLQSPLLFMFGKVGRPVSLRLHGRGQIGLKGATYRLNPLISYDSGFAQTVLQGTYEVEFPEILEVQPDGTLVPKKPGTTQVRFVKGGCRIPKRSRWWKSCPNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNU8</accession>
    <name>A0A398CNU8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FMN-dependent monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_02555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05036">
        <property type="protein sequence ID" value="RIE05036"/>
        <property type="gene ID" value="D3H35_02555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="150"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="223"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="472" mass="52949" checksum="70A5632E02563013" modified="2018-12-05" version="1">MKQIHLGVFEVNAVNHLTPGIWTHPEQNRIHFNSIDYWVEIARLLERGKFDFMFFADTYSYPKKNKELAFREAGGAPGNDPMLLIPALAMVTEHLAFTMTTSTTYETPVANSRRFSTLDHLTKGRIGWNVVTTSNPTAADLFGRTDFLPHDERYDMADDFLEASYKLLEGCWEDDAVVIDREKRIFTDPAKVHLVVHEGKYFKLQGYHSPSPSPQRTPVIFQAGSSERGRIFAANHAEGVFLKAPTTAILREQVADIRRRAKEIGRDPASVKVFTGLSVVTAPTREEAQRKYESYLSHQSRESALASYSSVTGIDLTKLDPDSYFENVHTEMGQTHTDRFTKYSPTKKKVREVIDDFLKKGFRGLTVVGAPEEVADQIQAWVEETDVDGFNLEPYVLPGTYSDFIDLVVPILQERGLFKKDYAPGTFREKLFGPGSARLPASHPAAAFRNAARLNPAAEDDAAPLPIGEGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP34</accession>
    <name>A0A398CP34_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02518">
        <property type="protein sequence ID" value="RIE02518"/>
        <property type="gene ID" value="D3H35_17665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="75" mass="8380" checksum="095581933EC9E4BC" modified="2018-12-05" version="1">MIWKLTLAFAMIAAYEYGLLRRIKAGKKLYASVFVTTALCYVYGIAGTLSPNLVNPNIPIEALFGSIQDRIQLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPA7</accession>
    <name>A0A398CPA7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01737">
        <property type="protein sequence ID" value="RIE01737"/>
        <property type="gene ID" value="D3H35_13095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="175" mass="20013" checksum="5983C116A4FFB45E" modified="2018-12-05" version="1">MKKALLIIDMQAMPFVWKSYGGKSLYQEARLIANTRLLIEKARKNASPIFYIMYTETTGPRSVDQPLWQIIDPIAPEPHDSLVIKYHADSFHETNLNALLRNHAIEGLVVCGIQTEYCVDTTVKSAYSHGYKVELASDCHSTYDSEEWTAEQIVLHHNNTLKHFASIVRSDEIQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPH4</accession>
    <name>A0A398CPH4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00834">
        <property type="protein sequence ID" value="RIE00834"/>
        <property type="gene ID" value="D3H35_26305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="185" mass="21694" checksum="1F6843E9D4590F82" modified="2018-12-05" version="1">MIDCRDVYLREYILDDLEKFHSLTWQPEIHEYLPGWNVSKEQREDWFINYEIPENKQFLNAVLEGGDIGELRLRLGILLKGTGDFIGWCCTGIKDELPTPNREIMFAISKDHRGKGYTTQAAQGLIKYLFENTNVEVLNAIALLRNVPSNRVIQKCGFIFQNTKEIDNERYNNYMLRKSEWEIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ23</accession>
    <name>A0A398CQ23_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_06720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04300">
        <property type="protein sequence ID" value="RIE04300"/>
        <property type="gene ID" value="D3H35_06720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="329" mass="38380" checksum="D3D99A32551947CF" modified="2018-12-05" version="1">MEIGGFRELDLRQGYEFYSGNNVARLNSGRYGIFHALQLLGCSKILMPYYQCDTVRDYLLSQNIEIEYYHIDSNFYPILNSVIEKDRALLIVNYFGIISANYLSEVIEKNPNVIVDNTQAFFSAPIPASYTVYSPRKFFGVPDGCYVYGENATHLLEKYEEDLSSPTSSFLLSRIETGGNANYQNYCINEERISSSGLRRMSKLTHALLDNIDYEYCMNKRRENFKIACDLFDSINCISIANINVNADLCIPMVYPLVIENEDLRNKLVSNRIYIGHWWEYLINELPFNSIEVYYSKFLIPIQIDHRYDRKHIQYVYELIARIVEEDHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR37</accession>
    <name>A0A398CR37_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protease PrsW</fullName>
            <ecNumber evidence="11">3.4.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Protease responsible for activating sigma-W</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D3H35_03760</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the degradation of specific anti-sigma factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protease PrsW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="11"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04620">
        <property type="protein sequence ID" value="RIE04620"/>
        <property type="gene ID" value="D3H35_03760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023596">
        <property type="entry name" value="Peptidase_PrsW_arch/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026898">
        <property type="entry name" value="PrsW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36844">
        <property type="entry name" value="PTHR36844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13367">
        <property type="entry name" value="PrsW-protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016933">
        <property type="entry name" value="PrsW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE04620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="231" mass="26299" checksum="4461EE1119E2F0CD" modified="2018-12-05" version="1">MLILSVLAAAIAPGIALLAYFYWKDRYDSEPLPMVAKLFLMGALIVLPVMILQRSLTLGLGESPFVFSFVISAGVEEFFKWFVLYHIIYNHTEFDEPYDGIVYATAVSLGFATLENVLYVFVQPATFGTLLIRALLPVSGHALFGVFMGYSLGKAKFSTGRAVTLHLWLAFLLPLVWHGLYDWLMLIVPSTWGWIFVPFMFLLWLRGIRYVNRANAVSPFRWLKRDEEIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRI3</accession>
    <name>A0A398CRI3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03879">
        <property type="protein sequence ID" value="RIE03879"/>
        <property type="gene ID" value="D3H35_07875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="93" mass="9672" checksum="C00CD3D64B65937E" modified="2018-12-05" version="1">MSKASEEFSSFVGGLKQEFDQFSAKFAAAVKEGAEAAGEQIMPSVEEFSRPSSVFAEKFAAAVKGGATVAGGQIMAAGMEFVQALIASKTKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRK3</accession>
    <name>A0A398CRK3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_02040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05172">
        <property type="protein sequence ID" value="RIE05172"/>
        <property type="gene ID" value="D3H35_02040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="92"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="295" mass="31472" checksum="1D327A8566F02C67" modified="2018-12-05" version="1">MNAESVTLRPSRSSRLIRVRMRWRISWTGLVLGLAGLAVVFLALCAIAPQWIAPYSPLVMNVDAILNGPSAGHWLGTDQFGRDVFTIIVYGSRQSLLTGIGSVLIGGLIGSLIGLLAGYRGGWIDSLFMRLIDVVMSIPGILLAVSISVALGSSQLNVILAVSVAMIPGYARVVRGQVITVKSRPFIDAARAVGASNTEIMLRHVLPNCFSPLLVMAAMGIGSSILMGSSLSFLGLGEIGEIPDWGFLLSQGRSYLTVAWWIATFPGLAITCLVVAVNVLGDELRDRLDPKSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRL8</accession>
    <name>A0A398CRL8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphonate metabolism protein PhnM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">phnM</name>
        <name evidence="3" type="ORF">D3H35_01460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05215">
        <property type="protein sequence ID" value="RIE05215"/>
        <property type="gene ID" value="D3H35_01460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019700">
        <property type="term" value="P:organic phosphonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012696">
        <property type="entry name" value="PhnM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038971">
        <property type="entry name" value="PhnM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02318">
        <property type="entry name" value="phosphono_phnM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="52"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="394" mass="44147" checksum="AE0C17F5A875686C" modified="2018-12-05" version="1">MYLIKNGIIVTEEALLEGFDLLVKSDRIVRIARSGEIAPEPGAEIIDAHGGYVTPGMIDVHSDYIEHMTAPRPTALMDFRLSLRETEKELIAHGITTMYHSLSIFKSADYKYRPIREPENVRKIIDLIDRTHVDKHLVRHRFHARFEIDSIDEIENLKTYIREEKVHLVSFMDHTPGQGQYRDLEVYKKNIRGYQDVSDDGIEQILESHRTKPKMTEDAIREVAGMARERNIAIASHDDDSLEKLDLVKSFGTAISEFPITLEIAREAKRKGLFTIAGAPNVILGGSHSGNLSASEAVEDGCIDILCSDYYPAAMLHAVFQLASSGNSGNLADVFRLVSLNPARAVNIDEDFGSVREGKKADLLIIESLDDDAFPVITAVMVDGKLIQRTNYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRR1</accession>
    <name>A0A398CRR1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper amine oxidase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02467">
        <property type="protein sequence ID" value="RIE02467"/>
        <property type="gene ID" value="D3H35_17360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="1">
        <location>
            <begin position="79"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="173" mass="18934" checksum="0E33B0FCC9DD166D" modified="2018-12-05" version="1">MKKISRIAAHGIGYRSMAVRADGTLWSWGIGYTGDGTKWDRTSPVGIRSFDKEIIDKDPIFVEIDGTTLQFEQPPITLNKRTLVPLRAIFEALGADLKWNSTTSTITANKGAITIELVIGSSTALLNGKHVSLDAPPTIRNNYTLVPVRFIGEALGADVHWDENNKTVILKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRT1</accession>
    <name>A0A398CRT1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ger(X)C family spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_01765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKC lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05272">
        <property type="protein sequence ID" value="RIE05272"/>
        <property type="gene ID" value="D3H35_01765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008844">
        <property type="entry name" value="Spore_GerAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038501">
        <property type="entry name" value="Spore_GerAC_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35789">
        <property type="entry name" value="PTHR35789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05504">
        <property type="entry name" value="Spore_GerAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02887">
        <property type="entry name" value="spore_ger_x_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="400" mass="44367" checksum="EA50410E468A49C0" modified="2018-12-05" version="1">MIRKVSCVLLAIALASILNGCWNRREMNELAIAVGMGIDKIGEQYRVSVQVVVPGEVTSQKTAGRSPVTLYKTESATVFEASRKLTTISPRKIYFSHLRLFVVGESLAQEGLGEILEFISRDHEFRNDFYVVIARETSAESTLKITTSLENIPVTKMFASLETSEKNWSPTMTVNTDELIASLVSDGKQPVLPGLRVIGDQEIGGSKTNTERIDSPGNLQLSGLGVFKNDKLIGWLSEEDSRGYNYILNNVRNSVGHIGCPNGGKVTLEITRAHSSVKGTMIGERPRIEIGVRIEGSVGEVECAGLDLTKSATLFDLEKRAEHKVTEIMESVVEKAQKTYESDIFGFGEAIHRTDPQAWKTLKEHWDDRHFVHLPVTINVDFKIRRVGTVGDSFLNKLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRX3</accession>
    <name>A0A398CRX3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02111">
        <property type="protein sequence ID" value="RIE02111"/>
        <property type="gene ID" value="D3H35_15235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="78" mass="8262" checksum="211AEF200AF4FBEE" modified="2018-12-05" version="1">MFGACAEKAAVKVQCGLFGACARKAAVKVQCGLFGTCAEKVAVKGAFSLFGGASREQIQAFRTANRMDFLVWGNKQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS38</accession>
    <name>A0A398CS38_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05363">
        <property type="protein sequence ID" value="RIE05363"/>
        <property type="gene ID" value="D3H35_00830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="425" mass="47418" checksum="1CE0C1DE9BAAD3F3" modified="2018-12-05" version="1">MVDAHGNNLAFLLCTPRSGSSLATVMLQNHSKLFATQEMWFLMSLLDLKSAPRRAYGGGAILDRFFNGVLPGEAFEEACRSFALQVYNGLLRSGGGADTIIDKSPRYYYLLEFLDALFPRSRRIWLIRNPFAVLASYKKLGSSRGGSSDLTAMLGSSAFDIKAADLTVGLLRYCRYFSRPDPFAYRLHYEKLVADPRGQLTGLCRFLGTEYEDGMENYGERMGSSKSGLYFSMGVGDPNVAEHAAPHEDSVHAWKDVLTKREAELYGRMLGARVFVELGYGEQLEEAEKWAGVRFGQEPDDSLMALRARQLAEATGCSWEADYEMRSDFSGGEKKLSAASKTGRRVSDVDDDVRQPHDSHSQLLQLQMTVRALEQRLESGILEQRRLRSQLNAMKRKADWLKSAIPFGSRLSRLASAYMVGGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSI8</accession>
    <name>A0A398CSI8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YqzL family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_06210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04209">
        <property type="protein sequence ID" value="RIE04209"/>
        <property type="gene ID" value="D3H35_06210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025617">
        <property type="entry name" value="YqzL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14006">
        <property type="entry name" value="YqzL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="54" mass="5817" checksum="2F44E2B084927D20" modified="2018-12-05" version="1">MRDFTWHVFTQTGDIEAYLLYKEMDMAGSSFGASAADKTADLGEDGAEGDAEPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSN1</accession>
    <name>A0A398CSN1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TVP38/TMEM64 family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_09375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03758">
        <property type="protein sequence ID" value="RIE03758"/>
        <property type="gene ID" value="D3H35_09375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="PTHR12677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="231" mass="25392" checksum="D906AC18954D6039" modified="2018-12-05" version="1">MRRSTLLKIAAAAVVVGVLLWINYQYLRLSPERIREWVVSFGWIAPVIYIVMYIVRPFVLFPASVLSLAGGLSFGTWKGMAFTLIGAVTGAVLSFLVARGVVGSGFFKGKDDPRMMKLERAMERRGFMMVLLLRIAPFVPFDLVSYAAGAARVRLRAFLPATIIGTLPGTFAYNYLGASLTKGSWKEFAIAGIVFAAALAIPFLLRKKVQREVEESPEPTVQNGVGRGRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSP8</accession>
    <name>A0A398CSP8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_09500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03778">
        <property type="protein sequence ID" value="RIE03778"/>
        <property type="gene ID" value="D3H35_09500"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:glycolipid mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="PTHR12468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE03778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="338" mass="38700" checksum="1C8382D4A4B9D454" modified="2018-12-05" version="1">MKTAEVNVGSRASLGLARKREMRWWVWPVLVNLIILVAATYLPYFKSVAKDTMEFGDRAHFWFQWDSLWYMDIANNGYQDRKATAFFPFLPLLIRVLSNPYLVLLANQIAFVCCLHLLKKFFVRMNLNASQTRTAIWLFVLNPAAIYYSTLYTELWTVLFSLASLEMAAQKKWGWAALFAAILSSTRATALTFGFFPLALLVYSVLRADWKTSLRALLWGGSLLIGLLAYMTYLNGKFGDPFAFSATQSKDWDHYWVLPWKQVIEGLKDAMSGGIQIMKLPLLIVSLLFAFWGAVTIWKVPFRRAWHKWGPFYSFSQASFSRSASGPRIPPCTARSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSU3</accession>
    <name>A0A398CSU3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03828">
        <property type="protein sequence ID" value="RIE03828"/>
        <property type="gene ID" value="D3H35_09755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039498">
        <property type="entry name" value="NTP_transf_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14907">
        <property type="entry name" value="NTP_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="374" mass="43562" checksum="7A9F1239B02E65A7" modified="2018-12-05" version="1">MITIKLLNRLFRNQRPLLNGDAEYEAALAEIRRQSLAGQIHHLLIEHGMTSEPPSFFLNDLAELQRAEWMTNMTLKLEAEPVIASLESNGIRTIVLKGIWLSRILYGKEGVRRTGDIDILVRPEDVDRVTAVLAERQFHAASNDCGYPYHALFYKPAANGKKIAIELHWHLISSGSCMLDCNRLWEQSVPLTGYAHMREFAIPDQFYTLAIHGAKHVMCSVKHVLDLVRMLHLYRELIDYPSLLERARREHTYGMVVMALSVAYRLFPHLHVWKPFPECRRWFSWDQGLAFRRNAGFRKFKGFRFYGQQLVFQLAKLDNTRYRLRYVKRLVFPHKVEMRAYLGLPDTTPGWRLYVGWHGRFLTSGRSRRHAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSZ4</accession>
    <name>A0A398CSZ4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LTA synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_15090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02084">
        <property type="protein sequence ID" value="RIE02084"/>
        <property type="gene ID" value="D3H35_15090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="239"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="3">
        <location>
            <begin position="618"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="703" mass="80288" checksum="93AE873382748E05" modified="2018-12-05" version="1">MKRYFSLNPIVLFFLLPVVIILFVETVSRGSILQTLRWLFENPILFLMNYVVIFSVTRVFSILHGIWNTIAYLLFLLVFSLMAYINQLKLLYRGEPFYPSDFLLTSEGTDIAAYLNHLPIGKIVLFCLFFIGISIFTIKTTRKKIFNRSNSLLISLISLVLLFVFIQFGPGPVTKGLRLSDTNKTVRSGSYSQNGIVIGFLKYAHEDAIQKVKGYNKEAIKAIVQNRGSNFSVDNEFKPNIIVMMSEAFWDPTVMQEVQFDKDPLPFFHSLQEKYSTGTLLSPTFGGGTANIEFEALTGLTTRFFHDGSIAYLRYVKKPIDTLASILSRQGYKSTAVHSYHNWFYDRADVYRNFGFDNFVSGEFFHRPNQIGPFMDDRDFVTRVVKEMKASEEPDFIHAVTMLNHGPYRADRYQKYTNHVHGNLSADAKQVLESYTQSLMDVDESIKLFISQLEELNEPTILILFGDHLPLLGEDYEVYREAHYFNGDETDAEAYKRKFSTPLLVWNNFNGEKEELHLSPNFIPAYLLEKTRKQGNVLTDYLTEEYRKGITMLPDDILDKEFGIQENQLDPYRLLQYDVLFGGQFSYSPQEKPQAKSDYVLGSGPITVTEADATVREADGATVINVSGANFVADNYYFDFIQGSKIYINGEEQQTVYTNDNSIECVLPDKFNKSAAQLTVQVKVKDTKGSVLSQSNVVNVQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTD7</accession>
    <name>A0A398CTD7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copper amine oxidase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_15930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02224">
        <property type="protein sequence ID" value="RIE02224"/>
        <property type="gene ID" value="D3H35_15930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017248032" evidence="1">
        <location>
            <begin position="45"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="2">
        <location>
            <begin position="72"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="421" mass="46443" checksum="6FDD2A3B614A9320" modified="2018-12-05" version="1">MKYSRLGSADFHHRITGVDDRMKRLMLFVFAAVLAFGLTGTASAAGSAKPATATVLLNGKEVAFSAAPIVIKGKTYVEFRALFNALGYEIDYEAKTKTIKASTEGHKIEMSTGGDVAFVNGKTVASSGEIKVINSRTMIGVRFIAALTDKKVDWDGVTRKVIITNWGPTEEEKRAILGVFDKFRLIEAADDLEGFVQLFADDSGVDIKALLPNWERTKTQTTFKELLITDFSGDEAVVKVTDETVKVSGAFFPEYSSVYNATLRKSSSGEWGIYNIEVLKADILSVDKLFAQEISFPEADKAAIGALFDAQTKAIYEKKMDDFMATVTTKDDAEAEELKQQMQWFFDSFDIKRTIEKWAVVDSEENDQAIVVISALMEVNLNGIHFKVRTVFSDGVVKKGGKWTFSNTGSDSVPYLSEDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTN4</accession>
    <name>A0A398CTN4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_03870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04639">
        <property type="protein sequence ID" value="RIE04639"/>
        <property type="gene ID" value="D3H35_03870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="108" mass="11278" checksum="151C8B32D92DA3DF" modified="2018-12-05" version="1">MAGECVGAGRNKVLTVTMAGECVGAGRNKTLTVTMAGEWRGSGRNKALTVAMAGECVGAGRNKTLTVTMVGNGGGRAEIRHSQLLWRGEWRGASWNKALTVTCAILVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTW3</accession>
    <name>A0A398CTW3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dynamin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_04290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04709">
        <property type="protein sequence ID" value="RIE04709"/>
        <property type="gene ID" value="D3H35_04290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="PTHR10465"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin_N" evidence="4">
        <location>
            <begin position="66"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Dynamin_N" evidence="4">
        <location>
            <begin position="669"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1253" mass="137103" checksum="6FEFA1C09A721516" modified="2018-12-05" version="1">MSSRLTDRGTEGLSLPGTAAADPLVAKYRLALEEMARHTEEMGDAVQAEKFAELVAKLAKERLTCAFCGHFSAGKSTLVNALCGAELLPSSPIPTSANVVTIASGEPSARMVFRDKDGHVSEPETFPVDRLHGFAVDGEGVASIEVTYPIPLLGDHVAIVDTPGVDSTDGAHRAATESALHLADVVFYVTDYNHVLSEVNFRFLRSLAKWGKPTYVIVNQVDKHREEEVSFAAFRAGLNDAMEQWRIEPAGILFLSLREKDHPLSQWRELTGLFARLAPYRTELAVASAERSARYLSDQFRETLHNRRHSEREKLQLVLGAEGAELVAARKSELTAKLAAVKSASDLRREALKRELDRLLGNASLTPAETRDKVRDVLEGMQPGFKIGWIGSAAKTQAERERRLSVLTADLNRQISANVNGHVRTLLRQTAKEAGLNGTDEANMEASLEAAFPELTDEWIRQRIKPGAGADGQATLTFSSELSSDIKAMYRKQSMEWNDRLEESRKPEREAAERELLQQLKELEPQSAAAAELAAMSDEEREEQRKLLLRLPVLDEAVVSKLAELPSPQPLNAEALAKIAGENERGAAALSWSDAAGSRRMDEGLEEAAEIAADGTTERQPDEALGVPNGAAERLGKAAELLSRIPALARTAEGLAAKAERLRRSRFTIALFGAFSAGKSSFANALVGAPALPVSPNPTTATINRILAPEEGKPHGTALVTMKAMEAMLEDIRHSLGRLGIARDAVEAAGNDASALFALAAKMSPDEVHPRGRPHLAFLRAASNGWPKFSELLDTKFLADHADYRRYAAEEETSCFVAEIDLFVDSPLTRSGAVLVDTPGADSINARHTGVSFEYIKNADAVLFVTYYNHAFTEADRQFLNQLGSVKDVFELDKMFFVINAADLASSETELKAVEEHVATQLLKHGIRKPRLFPVSSLHGLKAKLARDAGTLESSGLTAFEREFRHFAASELGGLALNAANKELERAGLLLEGFARSAEEDGVSRAAKADRLLAKARAWREEGSSSAIPETAVQPLVQEIGEQLYHLRQRVYYRFNEHFQSAFHPSALQDDGRDLKAMLTACGDDLTRSLGEDFQQELRSSGLRLEITVQKLLEERIALGAAALAEEGFVPEQPDRGPLTLPIGDPFADRPVSDGRKLWSAFRSPKHFFEKDGKKAMREELESIYFQAADDYLAKLKNEWNDSAIDGYRSSLKEASERLAAELSAFAQSLGESMSKPGEEAILSDVRAAWNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTW9</accession>
    <name>A0A398CTW9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable chemoreceptor glutamine deamidase CheD</fullName>
            <ecNumber evidence="3">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheD</name>
        <name evidence="4" type="ORF">D3H35_11500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CheD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.44" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03307">
        <property type="protein sequence ID" value="RIE03307"/>
        <property type="gene ID" value="D3H35_11500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16352">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01440">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038592">
        <property type="entry name" value="CheD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005659">
        <property type="entry name" value="Chemorcpt_Glu_NH3ase_CheD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35147">
        <property type="entry name" value="PTHR35147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03975">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="164" mass="17251" checksum="2FE40F461583EC55" modified="2018-12-05" version="1">MTESTYIKVGMADLNVAVGGAVLKTTGLGSCVGLTLFDPVVRVGGMAHIMLPSSDIAKEGQLNVAKFADTAVPQLVKQMQEQGAIIRRLVAKMAGGAQMFAFAGNSDTMRIGPRNVESTKLALSEFAIPILSEDTGGNFGRTVELSSETGVFVIRSVQFGVKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTX5</accession>
    <name>A0A398CTX5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CapA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_04340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04719">
        <property type="protein sequence ID" value="RIE04719"/>
        <property type="gene ID" value="D3H35_04340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGA_cap" evidence="2">
        <location>
            <begin position="5"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="322" mass="35567" checksum="3999715C12C31A6A" modified="2018-12-05" version="1">MRYVSLVRAGRPDLHASRLGNRQSGDASGRRGPEVYRLSQVQCTGGIGRCLERRGVQLVSTANNHSMDRGFTGIVRTLRNVRQAGLVPFGTSSSPEDAERLVIEERNGIKLGLLACTYGTNGIPVPEDKKYAVDLIDLPAIREHIHRLREAGADAVSVSLHFGTEYQRMPNEQQIAIAHDVVAAGADVVLGSHPHVVQPYDIIEVSAADSADGEPHRGVVIYSLGNFISNQSEEWQDVGLIFGIKLTKTTDANGESRTEWDAISLTPTKVHMQRVNKKKYYTILPMEQSIKAHNNPKLTAQDYTRMTKQLESLNKHLQSLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU17</accession>
    <name>A0A398CU17_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsU</name>
        <name evidence="7" type="ORF">D3H35_06145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005547957.1">
        <property type="nucleotide sequence ID" value="NZ_QXJM01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04198">
        <property type="protein sequence ID" value="RIE04198"/>
        <property type="gene ID" value="D3H35_06145"/>
    </dbReference>
    <dbReference type="GeneID" id="66664470"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00358">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_S21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018278">
        <property type="entry name" value="Ribosomal_S21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038380">
        <property type="entry name" value="S21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21109">
        <property type="entry name" value="PTHR21109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00976">
        <property type="entry name" value="RIBOSOMALS21"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00030">
        <property type="entry name" value="S21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01181">
        <property type="entry name" value="RIBOSOMAL_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="57" mass="6758" checksum="96DB859824C2BC5C" modified="2018-12-05" version="1">MSETKVRKNETIDAALRRFKRSIAKDGVLAEVKKRKHYEKPSVKRKKKSEAARKRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU19</accession>
    <name>A0A398CU19_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysM peptidoglycan-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_04635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04769">
        <property type="protein sequence ID" value="RIE04769"/>
        <property type="gene ID" value="D3H35_04635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="91"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="147" mass="15985" checksum="39078AAF26588300" modified="2018-12-05" version="1">MVHAWVIGSASKMTTNQSAATQQQARSYRKNQSTSLKKAAANRGENATISGIRVVRIVFVLVAFLILFSGFTLVHSFASPNANVPASAEETVVLVDSGDSLWSIASSYKKKEMDTRKAVHHIMKRNGLEESSLTTGQKLIIPVEVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU47</accession>
    <name>A0A398CU47_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04799">
        <property type="protein sequence ID" value="RIE04799"/>
        <property type="gene ID" value="D3H35_04840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="250" mass="29015" checksum="204C177C527A6EB4" modified="2018-12-05" version="1">MKQTILFDLDDTLIHCNKYFNLVLEQFADEMTGWYGPYGISRGSILDKQTEIDIAGVHVLGFEPDHFPQSFIDTYRYYQTVTGRSSSTYEEDKLWKIGNSVYELEFEPYPHMEETLEVLKRSENELHLYTGGDPVVQRRKIDKLKLDRYFEDRIYVRKHKNEQALEQILSEGSFDRALTWMIGNSVRTDVLPALHCGIHAVYLKQQTEWTYNVLPIETKPSGAFLTIGSLPEVPPAIHSYLQQISLKEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU82</accession>
    <name>A0A398CU82_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Collagen-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02831">
        <property type="protein sequence ID" value="RIE02831"/>
        <property type="gene ID" value="D3H35_19560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="774" mass="69537" checksum="E7722C8955C052D2" modified="2018-12-05" version="1">MSQANIPNITPDITLTREDAINLLLSSIALEELGLSHIINAEGEKIQLVLGTLPGVTSPPVTISDILAVNSSVQDTLREVTKKEWLLQNKLELILSTPISLGPTGPTGPTGPTGPTGTIEPGTELFTVIGTTGSATVDIGDNVTFLSNTLDIIVTQGSANVQIEIPETPLGPTGSTGATGATGSTGATGSTGSTGSTGVTGAGETGATGSTGATGSTGATGSTGVTGAGETGATGATGSTGATGSTGATGSTGVTGAGETGATGATGVTGAGETGATGSTGATGATGSTGATGSTGVTGAGETGATGSTGATGATGSTGATGSTGVTGAGETGATGATGATGSTGATGSTGVTGAGETGATGATGATGSTGATGSTGVTGAGETGATGATGATGATGSTGATGSTGVTGAGETGATGATGATGATGSTGATGSTGVTGAGETGATGATGATGATGSTGATGSTGVTGAGETGATGATGATGATGSTGATGSTGVTGAGETGATGATGATGATGSTGATGSTGATGATGATGATGATGETGATGSTGATGSTGSTGATGSTGATGSTGATGATGATGSTGATGATGATGSTGATGATGATGSTGSTGSTGATGPNFASTGFSASLPAVGVAGPGNVQLTNWSVVSPFYGNAAFNTTTGNFTVPTTGRYSIEATINYSTTATINVQLGAAVNPAFAIQRSSVNLLSGLFPVLDVNIALLLNLRTILGSGTVTIAGELQLNAGDVIGLFYLSAGLTIGLTIGGSTTPGVVWSIHEMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUD3</accession>
    <name>A0A398CUD3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02594">
        <property type="protein sequence ID" value="RIE02594"/>
        <property type="gene ID" value="D3H35_18090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="554" mass="62245" checksum="1B246EDFB6941A09" modified="2018-12-05" version="1">MKKTRMFPFERNRYFYGKLLTVRDFESEQKYFNDKRRLLNRLLFGSGVVAGMQVVPVDDKTITVEMGVALDYLGREIVISSPVTLKLSMIEGFTNNEYKKNVYLYAAYDEKGREPVHSVGNSSVRGEEVNEYNRYLESYRLFVKEEPPAPASFEHAGLLEDIVTLYQDSHVRVTQRMPKYANPGDVVDVVLIVEKTLQTPRVSLAFDYSAEGFDPLGKDGSSVRFLEPGDSQETEYRHSYSVKVQDKAGTVGKLTLRPEALELFIGDNRIPIDHTVTHGVDIIEQPVAERVLKDWYERPLDQAVEGYADQHVCLAKIGLLQLGPTYMIEQVERVPFGEYIPNASLMQRITLNGRSSSLNRFYAEAKAYDLSYGSTPELDVVYHPERNAFDFKLGIPKPQAIHDEIATGMLEVPLEKNAKTGLRLFSRGQRNFVTEEIAHGLGTGHVTIVVGLEETPKADAAVGSDGERVYYGAVDVFKDTEYEAELPGVSFGTLVYPDKGTFRIGMKLKDTAEISSLRVRWWAFKKLHDGVESSIPADIAEAIAFSQAAASEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUR4</accession>
    <name>A0A398CUR4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000035">
        <property type="protein sequence ID" value="RIE03607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03607">
        <property type="protein sequence ID" value="RIE03607"/>
        <property type="gene ID" value="D3H35_10735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="59" mass="5999" checksum="2328A19BA22E5303" modified="2018-12-05" version="1">MSPYKAGFALWLKLRAKDIFGPAGDGASPVCLSNSISFTVPSINGTGASRATRADAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUZ2</accession>
    <name>A0A398CUZ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02834">
        <property type="protein sequence ID" value="RIE02834"/>
        <property type="gene ID" value="D3H35_19585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="357" mass="41458" checksum="865A293A7FC13A04" modified="2018-12-05" version="1">MIKISLCMIVKNEEDVLARCLDSVKGIADEIVVVDTGSTDRTKEIAAKFTNKVIDFTWVNNFAAARNFAFSQATKPYLMWLDADDVILEEDRAKLLRLKRTLAPDVDSVVMTYCLQKDSYGNITSSSRRNRLVKKARQFRWIGAVHEYLEVLGNIFHSDIVVTHSSTHHDSDRNLRIYEEMEREEREFTPRDLYYYGNELLDHAQHTRAIEQYKKFLATGQGWIEDNISTCGKLADCYHHLNDQEQALEHALLSFKYDKPRADFCCRIAYYHSSKNEIAKAIFWYELAAGLKWDPSCLGFYNSACWTWLPHLQLCVCYDRLGQYEKANEHNEKALAFRPDDASMLANKKYLEGRLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV03</accession>
    <name>A0A398CV03_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03697">
        <property type="protein sequence ID" value="RIE03697"/>
        <property type="gene ID" value="D3H35_10385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010719">
        <property type="entry name" value="rRNA_methylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35276">
        <property type="entry name" value="PTHR35276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06962">
        <property type="entry name" value="rRNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="192" mass="20450" checksum="6A73B52EE30D177B" modified="2018-12-05" version="1">MGFLSVLSMAQRFVTERAVAGDTLVDATAGNGVDTLFLARLAGERGRVFAFDVQEAALANTRDRLDREPSPCRLAEVTLCQAGHETMAERVPRSLHGGVRAVMFNLGYLPGADPAVITRTETTLAALEAAVGLLAVGGALTAVLYPGHEGGGDEAKAVEEWFGRIPGERAQTVVYRFPQKPAAPYLVALEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV69</accession>
    <name>A0A398CV69_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04448">
        <property type="protein sequence ID" value="RIE04448"/>
        <property type="gene ID" value="D3H35_07640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="648" mass="72010" checksum="A3A9339B3B521971" modified="2018-12-05" version="1">MSFTCPKLSSNSAEGSPGSGSFVSAGLQAYSESGHPLNLTYSVGTTNAACWSSGSSNDGEIKCSQTEFEDAKLTIRIKNENNYQLKFCGYWNDNSNGASNWYWAPGPRDVPPPGCKRTIYLLDDDKAGLFLKVLDTNGLDQLGFANMSFQNGGTPSAEGSPDDSNNGLVAAGLQRYHRDVVAASLEYQIGESNRACWNHGDSNDGSTTCNQTTFKDKRALIFIENTIPETLTFVKYWNDNKGGAGNWYIEPNADDTVPPDCKRIFVLKDNDRAGLYFKMNYIEFHMSFTCPKMSSNSAEGSPHTGLQTYSGSGTPVTFTYRVGTPNLACWSSGTSNSGKTVCPQTLVLPFDLRRWMGKVNEKYAGFKNQKLRQLFIPGTHDAACYNNSGVATPWVQTQQVNFHDQLMLGARYFDVRPKYVHEGEGEWSHGFHHGPITVAATLDDLISQVTAFYTEDWQKRQNEIIILDFTHFDNYDDKERPGALQSFFTALYNSSLNPYLIPQGSFGPNTTLNSLWTASTQQRVIASVNFDPSSYQNTGNIWNGKKLFADEWDGSKFWPNTDKQTDLIQFINNNISTFSALTNLWALQDLLTPGLTSSVYSLVDQAHGALYGPSGLSWRSQANIVIQDYYDDRTTIEAIIENIRRISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV71</accession>
    <name>A0A398CV71_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lasso peptide biosynthesis B2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_09545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03787">
        <property type="protein sequence ID" value="RIE03787"/>
        <property type="gene ID" value="D3H35_09545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032708">
        <property type="entry name" value="McjB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13471">
        <property type="entry name" value="Transglut_core3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Transglut_core3" evidence="2">
        <location>
            <begin position="35"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="160" mass="18033" checksum="019BCF2B9C52B613" modified="2018-12-05" version="1">MNAAKHAIKFFSMRDGYRGLLIESFLYLAWARFLIALPFTKVAPSLGSPMEETPHEPGTADRNELKKISAALHMVSRHTLWSSKCLVRAIAGMKMLERRRIESTLYLGTAKDKNGEMIAHAWLRSGTFYLTGAEEMRKFTVVGKFAKSINHEGLEGWNDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV72</accession>
    <name>A0A398CV72_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_17010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03161">
        <property type="protein sequence ID" value="RIE03161"/>
        <property type="gene ID" value="D3H35_17010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="66"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="290" mass="32731" checksum="2425B97F1142B2D7" modified="2018-12-05" version="1">MKTEKWYGLMFISPMVVGYCVFLLGPMLMAFAMSFTDWSLIRELSFVGFDNYRKAFTADPVFMTTVKNTLLYSIGFVPPAILIPLGLALILKGKFFGVGFFRTAVFTPYVIPIVVWAILWKYILQTDNGLINSLLNTLGIQGPAWLYNLSLALPTLIVVSLLKGLGMNMIIFITALNDVPKTYYEAAKIDGVSKWKNFIHVTLPLISPSIFLVSILTLIGSLKVFALVYVMTDGGPGTSTYVFVYYIYQLAFKIYEFGYASAIAFILFVIILSLTLVQWSVRKRWVHYEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVR0</accession>
    <name>A0A398CVR0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar biosynthesis protein FlhF</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Flagella-associated GTP-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">flhF</name>
        <name evidence="13" type="ORF">D3H35_11470</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03301">
        <property type="protein sequence ID" value="RIE03301"/>
        <property type="gene ID" value="D3H35_11470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020006">
        <property type="entry name" value="FlhF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF3">
        <property type="entry name" value="PTHR43134:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03499">
        <property type="entry name" value="FlhF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="7" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="13" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="11">
        <location>
            <begin position="257"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="12">
        <location>
            <begin position="258"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE03301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="454" mass="49361" checksum="6F4C5DD021D77BBF" modified="2018-12-05" version="1">MKVKRYVVDDLPQAVQMIRSELGSDAVILNTKEIRTGGFLGMFRKKRVEVIAAIDEASRKPAPRPAAPTKPIVRKSEPSEESAIPAVQLPNAAVRERYARSTGTSDAPAVRTSAVPSAASAVAVAVPAESPSKEAPERGAFAVPDDPRPARPVQAGAGLAENPDTASLLTELRSMKEMMVKLSKQQTFRSMPDSVMNWSRRLAEQGVEAPIIERFAEEVNDRLGTEGADDESAALSVAREVLLEWLLPSAGSGINSSTRIVHFVGPTGVGKTTTIAKIAADQSLTHHRTVGLITSDTYRIAAVDQLRTYADILNLPLEVVFSPSEAQRAFKKFEDRDLVLMDTAGRNYRNELLVSEVNSMLSPGEHAETILVLSMTQKYGDMKSVASQFAKYGVTRLLLTKVDETDSYGSILNLALEYSFAISYITCGQTVPDDIRPFDPNEWVSRLLGEPAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXS9</accession>
    <name>A0A398CXS9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_09580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03794">
        <property type="protein sequence ID" value="RIE03794"/>
        <property type="gene ID" value="D3H35_09580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="3">
        <location>
            <begin position="37"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="231" mass="26199" checksum="BC86DDBD59AC46A8" modified="2018-12-05" version="1">MAEPSKELDFAYGSGTYFPGARTQVNQKGLRFYVGFKRMMDVVIATAALVVLSPFLVIIAAGVKMSDRQGSVFFRQIRIGKNGRPFHMIKFRTMVTNAESMLGDLLNRNEVAGKMFKMKEDPRITKLGKILRKTSVDELPQLINVIRGEMSLVGPRPPLQREVDEYSARDRQRLEVTPGCTGLWQVSGRNALSFDEMVELDLLYISSRSIRMDIRIILKTVKVMIFPNNAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY33</accession>
    <name>A0A398CY33_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03904">
        <property type="protein sequence ID" value="RIE03904"/>
        <property type="gene ID" value="D3H35_08015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="196" mass="22220" checksum="C0024649DEF2CD30" modified="2018-12-05" version="1">MTIRRATPSDSKEVSELIFLAIQDIAYQLTGETTEDRALASLEAYFLKNGNRFSYDKVSVKIADESVAGMILCYEGSEADSLYEPILRHLRRKNGDPDFEIDRETDAGEYYIDALAVFPEYGGRGYARQLLDAAEQCALDSNCSRIALNVEKNNEKAHSLYRKLGYEENKTITINGHLYRHMIKKPSPAQIFQFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYE0</accession>
    <name>A0A398CYE0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4349 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_06440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04251">
        <property type="protein sequence ID" value="RIE04251"/>
        <property type="gene ID" value="D3H35_06440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025645">
        <property type="entry name" value="DUF4349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14257">
        <property type="entry name" value="DUF4349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017352533" evidence="3">
        <location>
            <begin position="42"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="388" mass="42245" checksum="6F0A39D324597280" modified="2018-12-05" version="1">MKKKKGLVRETWSRYTVAAVVLLVFLTVLSACSGSSDNSEARAESAPMAGEAEQNAAPAAGDNFKSDSLLSKSNQVAKESQAGGSADLSAEPLTEQGTSVDSSSSLGIGQVADSQSGFGRKVIYNANLVMKVEKFQKAEEQLRDLIHQSSAYLLKFTDSRSADEVGATYVIKVPSTGFSPFLERLQKIKNVKFERQVDGSDVTEEYVDLEARLKAKTAVEARLLAFMDKATKSDDLVRFSNELGGVQQEIEQIKGRMRYLNENVAFSTVNLRLYEGPAEEAAKIVEEKDRSFGQRISDALAGSANVLGRFGEGLLIVIAAILPVVIVAAVVGVPAYLIVRKRRLTRISRSAENRSQWNQAIVNPPESQSDDRDSTSEAVRQEPEEGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZZ1</accession>
    <name>A0A398CZZ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YggT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_06580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YggT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04484">
        <property type="protein sequence ID" value="RIE04484"/>
        <property type="gene ID" value="D3H35_06580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003425">
        <property type="entry name" value="CCB3/YggT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33219">
        <property type="entry name" value="PTHR33219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02325">
        <property type="entry name" value="YGGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="89" mass="10070" checksum="EC6AE1A9438A4CE0" modified="2018-12-05" version="1">MADIASFIYLIESIYFYMILIYVLMSWLPSVRESFVGEFLGKAVEPYLKPFRRLIPPIGGMLDISPIVALIALKFVASGLVAVFDFFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D021</accession>
    <name>A0A398D021_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04811">
        <property type="protein sequence ID" value="RIE04811"/>
        <property type="gene ID" value="D3H35_04905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="304" mass="33531" checksum="1AA8B84F8D57FAB9" modified="2018-12-05" version="1">MKYRKLGKTGLQVSVVGVGTWQFGGEWGRTYEQSEADAILGRAAELGINLIDTAECYGDHLSESLIGNYIQGNRSDWIVATKFGHRFHNRFERTDEGDPAEVILQLERSLQALRTDYIDLYQFHSLPNVVFDRDALWEALDRQVQAGKIRHLGISIGSNENIHQTSRAEAVGAEAIQVVYNRLDRKPEAEVFPSCLEQNLGVLARVPLASGLLSGKYKPGAAFATDDVRSRRDRAAVEAQLVEAERIKREEVPSGTDMAAWALAWCLKHPAVTSVIPGCKDPAQVEANAAAVDLVEAGHPQDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0W0</accession>
    <name>A0A398D0W0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_03135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05131">
        <property type="protein sequence ID" value="RIE05131"/>
        <property type="gene ID" value="D3H35_03135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="63" mass="7608" checksum="908C9307A2B87DA8" modified="2018-12-05" version="1">MRWIERSFTELSGEQTRAGYRLYVFGFQSYIYYAKSGWHRKHFHSTPFGLEIKQQVKKDTISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDL0</accession>
    <name>A0A398CDL0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_26755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00793">
        <property type="protein sequence ID" value="RIE00793"/>
        <property type="gene ID" value="D3H35_26755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="235" mass="26271" checksum="2C4AF48F74D6D87B" modified="2018-12-05" version="1">MEWTKLTKRNHYEEITERLRRLIEDGSLKPGDKLPPTKDLSERFGVGRSTTREALSALKAMGLIDIRQGGGCTVIATAPAEVSLPELQSLRLNRATVLELLEAREALEVSNAAIAAVKRTDEDLAAMSQIIAEMERAVGDDAEGERTDLLFHLTLARMTHNSIMVRLFESIVGQMETAIREVRRVELYANHTVAEKLYEEHSAIFHAVSEGNPEAASDCMRRHLLHVGDILKKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF16</accession>
    <name>A0A398CF16_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arylamine N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01786">
        <property type="protein sequence ID" value="RIE01786"/>
        <property type="gene ID" value="D3H35_13370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="PTHR11786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="289" mass="33368" checksum="A9D670D4EBB4DE7F" modified="2018-12-05" version="1">MMIMTMEERSAYLKRLGIREIQAPTRTFLFELHKAHVNKLSWQTIDIFAGQPASMDVRESIQLMIGGRSGYCFQLNGAFCALLRSLGYRVSMHRAGVQPLGEAPRVNSFHLGLTVSMAGESNEEDETWIVDAGLGDMPYEPIPLRMGEYEQSPYTYKVVESGVVRDGWRLEHDPFASFAGVDFAPGIVQDISEFNSKHEYYSQSAESPWTQLLLVRHRHEQGSNELRGCIWSKRDRSGIEKTEIRTKSDWFALLGDVFGERLVRYSRQERDELWQKVKRKHEEWKRSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFB7</accession>
    <name>A0A398CFB7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_22060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01105">
        <property type="protein sequence ID" value="RIE01105"/>
        <property type="gene ID" value="D3H35_22060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="6">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="341" mass="37560" checksum="52B7991EA6AAE9BC" modified="2018-12-05" version="1">MGITIGDIAKKANVSKATVSRVISDHPKISAKTKERVLKVMDEFDYHPNMIARSLAHRSTKIIGVVIPGISEKSFKHPFFPEMLRGAASVAQKNHYNILMSAVSTAEMETQVINELAKGGIVEGIILMGATVHDKFISELLKLKFPFVVVGRPENQDSVSWVDNDNVQAAYELTKHFIEQGHSRIAFLGASSIDIVVIDRLEGYKKAMREHGLPINEKLIIEDKNIDGDGYAFMKALMKRQEPMTGLIAMDDFMAFGAIKYINECGLSVPDDIAVAGFNNVLLSNYSTPPLTSVEVNPFHLGTRAFELLIANLTSSYKSIDRAIIPADLVVRQSTLRGTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFD1</accession>
    <name>A0A398CFD1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_23120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01280">
        <property type="protein sequence ID" value="RIE01280"/>
        <property type="gene ID" value="D3H35_23120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="69"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="274" mass="30931" checksum="66F06D6CB2455EFA" modified="2018-12-05" version="1">MRTHPALRTVQYAIACLFTVTSLYPIFLMVASSFKNNLDIFREPFALPKSLDFSSYAKIFEDMPFLQYSKNSILVSAAVCLIVLLFGSMASFYIARFRFWWNNALFMFFLLGMMIPIKLGIVPLFLQMKKMGIIDSLGSLIMVYSAMGIPMAVLIMSAFFRTLPKELEEAAKIDGATNAGILLRIVIPLMRPALGTVLIFNFITAWNDFFFPLVFITDEMKKTIPVGMLSLFSQYSTNWNMVFAGLTLSSIPMIIIFFFASRQFMEGLTAGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFJ4</accession>
    <name>A0A398CFJ4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01195">
        <property type="protein sequence ID" value="RIE01195"/>
        <property type="gene ID" value="D3H35_22625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="157" mass="18073" checksum="5CE091F0A512EF23" modified="2018-12-05" version="1">MKISLEKAVEADAEFIFDIQVKAFQPLLELYQDYETNPANETLERVIARINNPQGGFYKILADHELVGAICVYWKEEGAPIWISPMFILPEYQGRGIAQQSITLFTEMFPHAAAWELATILEEQRNCYLYEKMGFVKTGVQKKLNDHATLVFYKKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFR3</accession>
    <name>A0A398CFR3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_26470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00742">
        <property type="protein sequence ID" value="RIE00742"/>
        <property type="gene ID" value="D3H35_26470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="152" mass="17148" checksum="9CD6D44735A12BB9" modified="2018-12-05" version="1">MLVEERIVTVGVLNRRGMLVMEHIVTVSALNRRGMLVEERIVTVGVLNRRGMLVMEHIVTVGVLNRRGMLVMEHIVTVGALNRPGMRVEERIVTVGVLNRRGMLVMERIVTVGVLNRRGMLVMERIVTVGVLNRRGTDSIFNTAHTVIFNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG77</accession>
    <name>A0A398CG77_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein adenylyltransferase SelO</fullName>
            <ecNumber evidence="9">2.7.7.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">selO</name>
        <name evidence="10" type="ORF">D3H35_13065</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-seryl-[protein] = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:58120"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:15073"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:142516"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-threonyl-[protein] = 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54292"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13847"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138113"/>
            <dbReference type="EC" id="2.7.7.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:13846"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:83624"/>
            <dbReference type="EC" id="2.7.7.n1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.n1" evidence="9"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01733">
        <property type="protein sequence ID" value="RIE01733"/>
        <property type="gene ID" value="D3H35_13065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PTHR32057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="94"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="129"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE01733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="492" mass="54773" checksum="2371074276C61BF1" modified="2018-12-05" version="1">MTIGKTPAEAGWSFDTSYARLPEIFYTRLNPTPVSAPELIVLNGPLAASMGLNAQWLRSEEGIAVCAGNRIPEGASPLAQAYAGHQFGHFNMLGDGRALLLGEQITPSGQRLDIQLKGPGETPYSRRGDGRAALGPMLREYIISEAMHALGIPTTRSLAVVTTGETIFRETELPGAVLTRVAASHLRVGTFQYAANWGTVQDLRDLADYTLRRHFPDVDDDAQDRYLRLLQEVMKRQASLIAKWQLVGFIHGVMNTDNMAISGETIDYGPCAFMDAYDPATVFSSIDIHGRYAYGNQPNIAAWNLVRFAETLLPLLHDNQEEAVKLAQDELEGFPQLYKHNWLGGMRGKLGIFNEEQQDETLIEDLLGMMKKARADYTNTFRALTFGRPDDTALYAIPEFALWHESWQARLGRQREQRDSSLQLMRSSNPAVIPRNHRVEAALEAAVAHQDYSVMERLLAVLSNPYAHSPEQDEYSAPADRSTIPYRTFCGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG96</accession>
    <name>A0A398CG96_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_25775</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00972">
        <property type="protein sequence ID" value="RIE00972"/>
        <property type="gene ID" value="D3H35_25775"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005671">
        <property type="entry name" value="LeuA_bact_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00973">
        <property type="entry name" value="leuA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="8">
        <location>
            <begin position="13"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE00972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="526" mass="57463" checksum="C7D182C9EB605790" modified="2018-12-05" version="1">MTTATNANNNKRIRIFDTTLRDGEQAPGASMKPEQKIIIARQLARLGVDTIEPGFAISSPGEFAAIQQISRELQEVEIAGFARCVRADIDAAVAATQDAARRRLHLFISSSQIHLDFQLRKSQDEVINMMKDMISYGKQSVDEIEFSPMDASRASEEFLFRMIEAAIEAGATIINVPDTMGYALPEEFGPLFTRIRKNVRGGDKVVYSTHCHNDLGLAVANSLAAIRHGVTQVEVSVNGVGERAGNCSLEELVMAIETRGGSFGVETGIRSEHIYETSRLVSRTMHFPIAFNKPIVGRNAFQHESGIHQDGLLKNRNTYEIMDPEAMGIPRNMIILGKHSGRHAIKHRVSEFGVQLTDTELDDLYGRFKEKADVQKIITDDVLMQLVGESTDSVVEPYSLTDVQVLAGSHRARIASVSIRSSEDGEERIFTGAGEGPLEAIIHCIRQAVPSGVEFEDLELHSLSTGEGASGEAVVTVVYEGQRYRGTAIHNDIILAAARAYVSACNSVAIAIRTGKAVVREEASGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGE7</accession>
    <name>A0A398CGE7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BrxA/BrxB family bacilliredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02296">
        <property type="protein sequence ID" value="RIE02296"/>
        <property type="gene ID" value="D3H35_16365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009474">
        <property type="entry name" value="YphP/YqiW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40052">
        <property type="entry name" value="PTHR40052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06491">
        <property type="entry name" value="Disulph_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04191">
        <property type="entry name" value="YphP_YqiW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="144" mass="15901" checksum="46B6251B5BA0014E" modified="2018-12-05" version="1">MSMSFERYMTDMIQPMRDELTRLGIQELRTPEDVESKLPEAAGTALVVVNSVCGCAAGQCRPGVASALTNDVTPDHLYTVFAGQDKEATAKAREYFAPYPPSSPSIALMKDGELVHFIERHQIENRSAQEIAADLTAAFDRYCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGY7</accession>
    <name>A0A398CGY7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_13050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01730">
        <property type="protein sequence ID" value="RIE01730"/>
        <property type="gene ID" value="D3H35_13050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="338"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="397"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="503" mass="52719" checksum="5481FE476E0400A4" modified="2018-12-05" version="1">MTVHAADADASSTKAMLTFGVAGAEGIVDEAAHTISVVLPAGVSRLNQIATFTTNGQSVKIGNGVQNSGQTANDFTSPQTYTVFAEDGLTQNYVVTVILANRLTSYDLISPVHATGAIDSVQHTITLDVPYGTDLSAAKAVFVTTGDHIEINGIVQQSGVTVSDLSLSPTIHAVDSENSVVPYTLIVNRALNPAKELTSFKITSPESIGVVNQNAHTVSITVPYGTIVTQLAPAFTSTGEDVKVGLQSQVSGVTTQDFTNPVTYSVYAADGTKQDYAVTVTAAAKTPSGGYDPSPSTPAPTEPEPTSPPAASIFKSAVDQAKIEAYLKDKVENAQTGPVSGGFPDVNEHWSKPNIDLFVTLGFIAGYNDGTFRPDASITRAEFASIIARVFHIEPAGGSRVLKDVKDHWAGNAIAALASNGIIAGYGDDTFRPSHAISRAEIIAIISRVVDFKAVEKNQTASFNDVAGSWNADEIQTAASAGIIEGRSGEPSLRTSPRLERKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH00</accession>
    <name>A0A398CH00_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phospho-sugar mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_14760</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02023">
        <property type="protein sequence ID" value="RIE02023"/>
        <property type="gene ID" value="D3H35_14760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="45"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="224"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="327"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="487"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE02023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="567" mass="61877" checksum="3F79C4A21594FA3F" modified="2018-12-05" version="1">MPKTPQQLFEAWLQDPTIDDETKVELTGITGQDKEIEDRFYRDLEFGTGGLRGVMGAGTNRMNRYVIGKATQGFANYLKGLSSEPSVVIAHDSRRNSDTFSVESACVLAANGIKTYLYRSLRPTPQLSFAVRDLKATGGIVITASHNPPEYNGYKVYNADGCQLVPHEAEQVIASIRAVESFDEVKRLTQAEAESAGLLVWLGEAEDQRFIDAVAASAVQPEWLRSGAGAGISIVFTPLHGAGNLPVRRVLAQAGFTNVHVVEAQELPDGQFPTVKSPNPEEHEAFTLAMKLADETDADLIIGTDPDCDRMGAVVKNDAGKYVVLTGNQSGALMVYYLLSRLKEQGKLPANGAVVKTIVTSEMGADIAASFGCEVFNTLTGFKYIGEKIKQFEQTGSHVYLFGYEESYGYLTGTYARDKDAVVASLLISEAAAYYKSQGKTLYSVLLDLYAQYGAYLERLESRTLKGKDGLEKIGAIMNDWRSNPPQEVAGVRVEKVLDYEKGLDGLPSENVLKFLLTDGSWFCLRPSGTEPKIKLYFAVRGESLDGAEASLNRLISVVMERVDSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH10</accession>
    <name>A0A398CH10_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_14815</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02033">
        <property type="protein sequence ID" value="RIE02033"/>
        <property type="gene ID" value="D3H35_14815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017348607" evidence="9">
        <location>
            <begin position="35"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="567"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="835"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="1108"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="1381"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR623612-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE02033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1554" mass="162315" checksum="5F770B6B84BB22C4" modified="2018-12-05" version="1">MNLWFGGEVQMKRKFISVLLVLVMLVSGASGVLAADLESGMPPAAVPKNNYEPSPNTKFKMGKLSEPLKDQASIISFALSQSKSNALKGIKPAYSFKIEKSKYDEAGRQHVVLQQTQNGVPIYGHYYQVSLDGNQQVYAVQDKSELDLSAVQTTKPSITGEQATNRLKSALEAFYGQPVELESDYKLFKYPKPTAELLIYPYEGKTYLAYEVQMSFLKPAHGNWIGYVDATTGEVIEKYNKIQNATAASGTGYGYNGAAKTINITRDEGYYFLFDQSHSGAIVSSSYNYDVDDEGYIYASWSRSSTFKDSGSLRRYRDVVDAHYNADIVYDYYLNTFGRNSVDGNGARILSIANLPDEDGYPLDNAAWDDSLNAMFYGDGSGVRNGGMNCTACSLDIVAHEITHGVTSHTADLEYRYQSGALNESISDIMASVIDSADWTIGEDTGMIGRSMQNPNLYDQPKTMSEYEYLTIDQDNGGVHVNSGIPNYAAYLMATKINSLGLNGKTILGKLTYNALSYHLTATSDFVDAKNSYLLAAGEISSLTEQQRKAVRLKIIDAWGEVGIPTVVADFSVTGHTPASVTFSWTAGSGASNVIIQQSADNGANWTTASTGVISTSAATATASNLLPATNYLFRLVINGGNSAGTSNLAAWTTEARTISDFAIKEKGSRFALFTWSKAIGATKVKIHKSENEGQTWEFVELPVESTQVMDAGLIPNKNYRFYLSVTGGGYQGKSNEVRFTTNAEPLVLNLVEAVAGSAKFQWEAPKGATGIVLQQTTNGTTWTTANTGALGLSAAGATVTGLQAATSYKFRLSVSGGQNNGFSNEKSITTASFPIETLAVSGKTTSTASLAWPALLKPTSLIVQQKTEGTGWTIAKTGTLSTSSKSATVSGLAANTAYQFRLVVTGGGNAGESNIVDAKTDAVKITSFAKNGNATVSAVPFKWTAALGATSVAIEQSTDGATWTLSATGSLAANASAATVSGLRPNKTYQFRLKVTGGQNEGSSNSVSATTVAAPLTDLASGEITGSTAELNWTAAVGASSVKAELSSNGGSSWTAAMVETAVGANASTAKVTGLLAGTDYKLRLNVTSGENNGLSNVISIKTAIVPVSTLTSSGKTTSSITLSWPALVKPTSLIVQQKTEGTGWTTAKTGTLSTSAKGATVSGLTANTAYQFRLVVTGGGNAGESNIVDAKTDAIKITSFAKNGNATVSSASFKWTAAIGATGIAIEQSTDGATWTLSDTGSLAANTSAATVNGLRPNKTYQFRLKVTGGQNEGSSNSVSATTVAAPLTSLVSGEVTGSTVELVWTAAVGASSVKAELSSNGGSSWAAATVETAVSANGTTAKVTGLLAGTDYKLRLNVTSGENNGLSNVISIKTVIVPVSTLTSSGKTTSSITLSWPALVKPTSLIVQQKTEGTGWTTAKTGTLSTTSAKVATVSGLTANTAYQFRLVVTGGGNAGESNIVDAKTDAIKITSFAKNGNATVSTASFKWTAAIGATGIAIEQSTDGATWTLSDTGSLAANGSAATVTGLRPNKMYQFRLKVTGGQNEGPRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH64</accession>
    <name>A0A398CH64_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01312">
        <property type="protein sequence ID" value="RIE01312"/>
        <property type="gene ID" value="D3H35_23300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="132" mass="14053" checksum="6ABF9EC05DB279EC" modified="2018-12-05" version="1">MFVEMDLQSEVPLYAQLVDSLIEGIASGALKPGDPLPSVRGLAADLGINLHTVNKAYTLLKQEGFLQVHRKQGVVVNPGGMPGITSAFDDKLTRQLKVLAAESAVRGMSAEAFADRCKEVFRTAVEGGGRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH78</accession>
    <name>A0A398CH78_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-dependent Clp protease ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_29965</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00258">
        <property type="protein sequence ID" value="RIE00258"/>
        <property type="gene ID" value="D3H35_29965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="9">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="8">
        <location>
            <begin position="417"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="413"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE00258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="816" mass="90781" checksum="9918E894C2903AA8" modified="2018-12-05" version="1">MMFGRFTERAQKVLALAQEEAVRLGHNNIGTEHILLGLIREGESIAAKALIALGLGLEKIQDEVESLIGRGQEQPTNIAYTPRAKKVIELSMDEARKLGHTYVGTEHILLGLIREGEGVAARVLNNLGISLNKARQQVLQLLGSSESVQTNHGPSSNVSTPTLDGLARDLTAHARDGHIDPVIGRSKEIERVIQVLSRRTKNNPVLIGEPGVGKTAIAEGLAQKIVNNEIPETLRDKRVMTLDMGSVVAGTKYRGEFEDRLKKIMDEIRQAGNVILFIDELHTLIGAGGAEGAIDASNILKPALARGELQCIGATTLDEYRKYIEKDAALERRFQPITVDQPSPDEAVQILHGLRDRYEAHHRVKITDEAIDAAVKLSDRYITDRFLPDKAIDLIDEAGSKVRLRSYTIPPNLKQLEGRLEDIRKEKDSAVQSQEFEKAAALRDTEQKIREELDTTKNQWKEKQGRTDSEVTPEDIAQVVASWTGIPVSKLAEEETERLLKMEEILHDRVIGQEEAVKAVARAVRRSRAGLKDPKRPIGSFIFLGPTGVGKTELARALAEAMFGDENAVIRIDMSEYMEKHSTSRLVGAPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHPEVFNVLLQVLEDGRLTDSKGRTVDFRNTLIIMTSNVGADQIKRNSTLGFTAAQDSGKDYANMKDKVLGELKKSFRPEFLNRIDEMIVFHPLEQEHIAQIVTLMADDLRKRLREHDVQFDLTEAAKNFLAKEGFDPAYGARPLRRAIQKHIEDRLSEDLLLGKINKGDLLVIDEKDGGLVVDTKQDEPVSNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHE4</accession>
    <name>A0A398CHE4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_29090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000057">
        <property type="protein sequence ID" value="RIE00328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00328">
        <property type="protein sequence ID" value="RIE00328"/>
        <property type="gene ID" value="D3H35_29090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="192" mass="21592" checksum="10A521F609DC0A0C" modified="2018-12-05" version="1">MFQTLYFAPVVLSTVALVQIFQNVFSVNPVGMLNYFLSWFQPSMLDSEWLSDPHRSLLIVAIAEGYKFAAVYMVIFYSALISISEEVIEAARMDGASGWKLYRYIKLPMIKGIIFTSIILVLNGSLKSFDIPYLLTYGGPGTSSELVATYMYKQAFSSMYYGYGSAIAVFIAVECFLLVGLVMQIFQMKKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHE8</accession>
    <name>A0A398CHE8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_15690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02183">
        <property type="protein sequence ID" value="RIE02183"/>
        <property type="gene ID" value="D3H35_15690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="58"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="247" mass="28314" checksum="3BA078EBF7057976" modified="2018-12-05" version="1">MTYMDSTKGRLQQNGQLSDLFSMLPDNCPGVNTNTSLYLEKISEVEPMNVRRERKDAAEHRKLILRTAESLFAEHGVNGVSMHQIAKTAGIGQGTLYRRYAHKGDLCCDLVNDHCVQLMEISTKLLEQQGKSSAEKLGELLDLWIDALEEKADLVIVIESQKPKEWDERGTTWFHSPMYRFMLDSTASLLRDLLQERPVQPFDPMLTAHALICSIAPAGYFHFRREQGYSVEQMKRAYRQMYQLPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHZ7</accession>
    <name>A0A398CHZ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1679 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02413">
        <property type="protein sequence ID" value="RIE02413"/>
        <property type="gene ID" value="D3H35_17045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="34"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="305" mass="35159" checksum="6C0B9B1B54F83689" modified="2018-12-05" version="1">MENSNQWDAEWEVSEELAYKLISSQFPQLATKSVKKLGHGWDNTVFLVGAEYAFRFPRREVAINSLRMEGKILPKLKDYFSIAYSIPLFFGEGDYNYPAPFLGYPYLFGEFPIGLTDKQRALSATTLAQFLKSLHAFPVQIAQENGVQNDHRNLTDIAMRKEKIHKFISDLARHFSEEEYHHAISNYLEQLRTERVNQKYVFLHGDLHFKNILVDENGRVSGIIDWGDINIGHPACDLNVVYSFLPPDARSDFFKEYGDVDEETKILSRLIAIYIPILIMMQAIDDKDERLVDEAKANIKRALSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI15</accession>
    <name>A0A398CI15_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2339 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_26735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00789">
        <property type="protein sequence ID" value="RIE00789"/>
        <property type="gene ID" value="D3H35_26735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019286">
        <property type="entry name" value="DUF2339_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38434">
        <property type="entry name" value="PTHR38434"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10101">
        <property type="entry name" value="DUF2339"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="539" mass="59027" checksum="2060A4C7FC2EDDCB" modified="2018-12-05" version="1">MNSNIRKHWTSLVGVLFVVAAFVTFFRYSIDQGWVSDAMKIGAGLVVGVGLALGGLSATVRSRQSVVSEIVIGTGACILFATFSFAGIFYDMWPSITVLIAMGTVTALVSAYAFRFDSRLLMNIALAGGLVSPMLMQPETDQVFTLFLFLLVLNAAYFFLSVAKRWSELRIAAFGGTWVLYAIYFVKFQPLMEGLWSMPIRYAFAAFVLYIAGFLYASWGNNRCFDGWNLYLSLTNGVLFGCWALYIWNGDVPAAATVAMIGAIYLIAGAFVYKMTGKAALYSLSHGFGGALLLLIAAAQTGAGLESKPLINVYLWSAVVVALIGIGRNRRLPILQWIAIPIWVVVCCYWFAVTWDTPRGEWFGVYIPFLNWGAISWIVLAAIGFYLAKNPVGKFASVQDEKVLANLYALLSHIIIGGLLTVQIENVFEEYVINPSGASLLQISLSVAWGVYAVLLFLWGSYNKQKLFVWFGSVVLVIVAVKAIFFDLSGEETLYKVLAMLLLGLLSFLISWVNGKWGGKQTASETPLSSNDSDTGVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI55</accession>
    <name>A0A398CI55_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small acid-soluble spore protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_14825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha/beta-type SASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02035">
        <property type="protein sequence ID" value="RIE02035"/>
        <property type="gene ID" value="D3H35_14825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001448">
        <property type="entry name" value="SASP_alpha/beta-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018126">
        <property type="entry name" value="SASP_alpha/beta-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038300">
        <property type="entry name" value="SASP_sf_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00269">
        <property type="entry name" value="SASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00304">
        <property type="entry name" value="SASP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="90" mass="9113" checksum="4387A3A12C28780E" modified="2018-12-05" version="1">MAGRNKKLVPECQAALNQLKYEVASELGVAFGGGSYGGTGEDTEFAGDLGSIASSGSGKAYLGSLSSREAGSVGGEITKRLIRSAQQTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIF1</accession>
    <name>A0A398CIF1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00969">
        <property type="protein sequence ID" value="RIE00969"/>
        <property type="gene ID" value="D3H35_25760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="137" mass="16762" checksum="29084CC20414FD5D" modified="2018-12-05" version="1">MRAGVWYVVPYIRRKALLRAEVWYVVPYIRRKALLRAGVWYVVPYILRRALVRAEVWYVVPYIRRKALVRAGVWYVVPYIRRKALLRAGVWYVVPYIRRKALVRAEVWYVVPYIRRRAIVRAEVWYVVPYIRRRALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CII7</accession>
    <name>A0A398CII7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02553">
        <property type="protein sequence ID" value="RIE02553"/>
        <property type="gene ID" value="D3H35_17845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="101" mass="12045" checksum="9301CDF3644B91E3" modified="2018-12-05" version="1">MTKGERELLHKLMKRAITPDLFLKEFTVDISKNPAYVRELLEKAYIEQEADDVEYLMIAIFRFELFLEDITESICKLMNETWHFQHENIASMFQKVKSQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIS7</accession>
    <name>A0A398CIS7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spore coat protein GerQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gerQ</name>
        <name evidence="1" type="ORF">D3H35_19090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03196">
        <property type="protein sequence ID" value="RIE03196"/>
        <property type="gene ID" value="D3H35_19090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014099">
        <property type="entry name" value="Spore_coat_GerQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09671">
        <property type="entry name" value="Spore_GerQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038931">
        <property type="entry name" value="GerQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02728">
        <property type="entry name" value="spore_gerQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="150" mass="16040" checksum="4C35D7C6B0E052A3" modified="2018-12-05" version="1">MPVQWPYSPAMPGAAPMAMPGTMAMPGTMVSPAMTTGMIPSAVPSGAPITPSGVTFPGGFGQEESYVENILRMNLGKTATLYMTYENNSEWNAKIFKGVLEAAGRDHIIISDPTTGKRYLLLTVNLDYITFDEPLNYTLPFGTGGTGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIZ9</accession>
    <name>A0A398CIZ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02072">
        <property type="protein sequence ID" value="RIE02072"/>
        <property type="gene ID" value="D3H35_15015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="122" mass="14412" checksum="AF5DAFE62B4C15FA" modified="2018-12-05" version="1">MIAIKALFQQLNEKTEDVLEFLRPSPQADEVDELDRLYEERESLLKELRKELASLSPAEVETYRPLYELWQVKETELRNLGEELLKKLDAKRMEAQNIRNLSGQYNSYLNQMPYGAYLDSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ50</accession>
    <name>A0A398CJ50_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RraA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_26090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000047">
        <property type="protein sequence ID" value="RIE00848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00848">
        <property type="protein sequence ID" value="RIE00848"/>
        <property type="gene ID" value="D3H35_26090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="SSF89562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="213" mass="23410" checksum="FCBB0418D5003296" modified="2018-12-05" version="1">MRNSLYGCHFGYAGRAWLPQSSYEREDQPDRSQLVVAGRAKTILSVDVHYLPEDPYAKEIEAVDSVKPGEVVIGCTNESKQNGLWGELLSTASKVRGARGAIVDGLIRDTKKILELGFPVFATGTKPVDSQGRGLVIDYDIPVKCGGVLVRPGDIIFGDRDGIVVIPSELAEEVFSLALNKATRENHTRDELLEGRTLRQVYDKYGFCKEGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJD5</accession>
    <name>A0A398CJD5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_16030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02242">
        <property type="protein sequence ID" value="RIE02242"/>
        <property type="gene ID" value="D3H35_16030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="7">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="225" mass="26020" checksum="B08FBB2A7408DE30" modified="2018-12-05" version="1">MKHMLITDDDANYRKLLGHYLTHEGFRVTEAPNGREAMAVLGKQVIDLAILDVMMPEVDGLTLCDHIRKNYDIPIILLSARDQLSDKEQGYLHGTDDYMTKPLELPELLFRIKALFRRYSLASSDKIKLNQLIIDRKNYEVAVGDEVFFPPLKEFELLAQLAEYPGRVFSRDELIRLIWGTDYSGDERTVDVHIKRLRKRFSEYEQGFAIHTIRGIGYKLEVSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJL8</accession>
    <name>A0A398CJL8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bacteriocin-protection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03516">
        <property type="protein sequence ID" value="RIE03516"/>
        <property type="gene ID" value="D3H35_12030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="193" mass="22386" checksum="2C318E060FF3B0A1" modified="2018-12-05" version="1">MLFFETPEQWRRWLEHNHDKASEQWFGYYKVGSGKRSVTWPESVDEALCYGWIDGLRKSIDGESYKIRFTPRKPGSIWSAVNRKRVEELTALGRMTEAGLSAYSKRTESKSGIYSFEQENVCLAEEDERLFRANEKAWAFFEAQAGWYRKAAVWKIISAKKEETRAKRLTELISSSENGRTIPSLTRPGKSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJM6</accession>
    <name>A0A398CJM6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02903">
        <property type="protein sequence ID" value="RIE02903"/>
        <property type="gene ID" value="D3H35_20015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024442">
        <property type="entry name" value="Transposase_Zn_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12760">
        <property type="entry name" value="Zn_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_Tnp_IS1595" evidence="1">
        <location>
            <begin position="12"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="303" mass="34471" checksum="4A41970BBA9B16AD" modified="2018-12-05" version="1">MNNESIHPFMDKEEDCQLALFAAKWPDGFRCPHCSHPHAAVIRTRRLPLYQCRSCRLQTSLIASTIMEGSRTSLTKWFQAIHLHSLPSGISASRLSRIINVTYKTAWLICHKIRHAMSSSEDSRRLAGLVRINASLYGRYESAHSDFPSMQVPLLIAASIGPHGEPEHMKIKLMKEFAQRKSITMQGVHTFIENHLSDDSLAEVIGTQSFYRLRKLRCPILKQTVQEARVWIRDTFQGIGPKHLQVYLDQFIWMLNARKTAENHPFDTLLSLSASLPVITYPVLIGKYPNSAQIRSRPQSKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJW0</accession>
    <name>A0A398CJW0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_22270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01138">
        <property type="protein sequence ID" value="RIE01138"/>
        <property type="gene ID" value="D3H35_22270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="115"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="251" mass="27244" checksum="FCF8B79EF739CABB" modified="2018-12-05" version="1">MSSYRWIKWRRLLLKLAVLAAIGGGMWAGAPTSWSIAVSLLGIAMNLLFAVLFIIIQFAALFWFLARGRTYWILPGETGATWDDYRGNPEIVENAKRIVTLLRGVKAFKDMGGEAIRGLLLCGPPGTGKSYLAQVIANEAQVPFAYASAPSFQNMFFGVGNLKVMRLYKKARKLAKIYGACIIFIDEVDAIGMKRQAGGMGAAACSGWGAARACSTSCFCRWIRRTSTAPGSRSCCGRSACGAGRRSARPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKH3</accession>
    <name>A0A398CKH3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ger(X)C family spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_18410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKC lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02652">
        <property type="protein sequence ID" value="RIE02652"/>
        <property type="gene ID" value="D3H35_18410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008844">
        <property type="entry name" value="Spore_GerAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038501">
        <property type="entry name" value="Spore_GerAC_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35789">
        <property type="entry name" value="PTHR35789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05504">
        <property type="entry name" value="Spore_GerAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02887">
        <property type="entry name" value="spore_ger_x_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="394" mass="43941" checksum="F17FD5AA8B69BC6D" modified="2018-12-05" version="1">MKNTIRLTLSLAVLLLTTGCWDRMELNDLSIITAIAFDKPDNDPIKVTVQILIPKIKGGGGIGASTGGAAHQTTIRSETGLDIADALSKLQLKIPRSIFWGQCKVFIFGEEVAKEGIIEHFDFLIRHPQPRERGYMFVSKGEASELLDLFPPIERSSSEVLRELMKKELSMSVTMEELSIMLKEGSRDAALPLVHILPKAKSSKERETIPYVSGAAIFKDGKMVGNISKEETRGVLWLRNEMQQHTVTVENEIEKGVVSINARKSKVRLVPAIEGGTWKMTVKVNTEGDIVQNGTRVNPMNRKLLKKLEAGFREAVSERIEEALEKIQREQKADVVGFGTAYHRKYPKHWAKAKDNWDETFSEVKVKIEVHAQIIRPGLLNSPGGIPADKALNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKJ8</accession>
    <name>A0A398CKJ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_19965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02895">
        <property type="protein sequence ID" value="RIE02895"/>
        <property type="gene ID" value="D3H35_19965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="14"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="417" mass="45203" checksum="F97C7D47305EDF3A" modified="2018-12-05" version="1">MNLVRKSLLRYDGGIWIRVIGAALTTITGFMIRPFLVLYLYDRLESVLLPMLVVALQPLCGLFVSWFGGGMSDRLGRKPVMIAALLLQAASMAGYVFADAIWQFAAVSVLNGIGQALFMPASNAQMTDMVPAERRAEVYALLHTAFNVGAAIGPMLGLALFRWNPQIVFFIAAGATCAYTLLVAFKMEETAPAVIARKSSGEKGLPSLRGGRQGGLKLLFRKERTLLAITLLSLPVSLLYTLAETAMPIHLQAHFDHSQAVFAGMLTFNGLAVIALQIWIARKTERMSSYKLIGCSYALFSIVAIGYGYSTAIVALYAAEFIFTIGEMIYGPHIQKEISLMAEEERRGFYFAVFGASRLLAAGIGPIAAGLAMEWANGETLFTVVAVLIVACGIGAFRLLRKQQAAKRTEQYGAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKQ0</accession>
    <name>A0A398CKQ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SRPBCC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02955">
        <property type="protein sequence ID" value="RIE02955"/>
        <property type="gene ID" value="D3H35_20335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="204" mass="23805" checksum="2130D4183EA0BE12" modified="2018-12-05" version="1">MPGPIFKQDLKEATGTSWEQWIIDLGRVVDPLWSHEQIKNYIRESYPVTEEWSEWLAIMYEQIMGRIPVGVTKDAGVQIGVRKTIVATKEQVWNFLASPKGLSLWIGDVPSLRLQVGHEYESKEGVSGKITVVIPYHKLRMTWKRPEWDKPSRLQIYTLAAKSEKTTVAIHQEMLDDVYMREVMRRYWEGMLNSLKNVEELRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKW6</accession>
    <name>A0A398CKW6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CotS family spore coat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01859">
        <property type="protein sequence ID" value="RIE01859"/>
        <property type="gene ID" value="D3H35_13810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014255">
        <property type="entry name" value="Spore_coat_CotS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02906">
        <property type="entry name" value="spore_CotS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0946">Virion</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="548" mass="60888" checksum="A12B16E22FCFC893" modified="2018-12-05" version="1">MEPYIVQPWDHLTAAELPGIVLEQYVPPELEAMAYEVMELYDMRVSEMTLITSKPDKGGAIWKIVTNHGPRSIKVLHREPSRSLFSIGAQQYLVEQGARVPQLIPTVEGALYVEAGGKLWIVTDWIEPLIPVSKVDVEGAASLCNGLGEFHRISKGYVPPPNAGKSSRLYGWKKNYEKIIAKIGWFRHIAEAYPETAASARLLSVVDEFERQALDIFARFQESPYGRMKAMGEPYWGLAHQDYGWSNGQMGPDGIWIIDLDGVAYDLPFRDLRKLITSTMDDMGVWDLTWVRGMIDGYHQANPIDQEMFELLWIDMAFPNEFYKHVKEVVFDPVTFMNLELDPILQRVMLTEASKWEALTQLEADKIKYEPGDYTAPEPVVDSPFAVMEFTVEGAPLAAFAASAPAMDPVLAPAVFEPPLVPAAAAAAAADPAAVPPAAVPLVRLVSQAPPARTPAAAASVRTPAAVGAENDPPAQPRRRRKAARKRKRSKSVKTAPSRLKRKSTRRKSATPLVAVRKRKKSSRSSRRPASANARSKRSRTTRRVRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKY7</accession>
    <name>A0A398CKY7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_08490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03986">
        <property type="protein sequence ID" value="RIE03986"/>
        <property type="gene ID" value="D3H35_08490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="598" mass="69366" checksum="41E143C29C8A9B8C" modified="2018-12-05" version="1">MMMRREAHRKRAGAFVPLFSVYSARSAGVGDFEDLKLAVDWCERTGQTILQLLPMNDNIASVFAPTSLFALDPEHVAIDRLVGVREDWRETAAAELRQAFPTGKGFVDYGVKMAKVTALRGLFERIGGDCPDPRFLGFLQKQRYWLHDYALFMAIKQVLFPGRWDEWGEPFRNRDPEALDAFAQENFNEIQFHKWVQWQLYEQLSEAKRYADSKNVQLMGDYFYIAMSDSADTWSNRELFRLDCCSGLPSEPSSPKGQRWDDQPVYDWSRIKADDYRLVKHRLAYYENFYHMLRIDHPAAFFRTWCIPFEEPWENQGQNGFFYPSDFEEWEEQGTGILRTILSNTKLTLCAENLGPFTTFFTPEVRGLGIPIINFQRWEKDYGNTYRFTDPKQYDYLTAIVLSTHDTSCWADWWDNEAGTVDTGWFRSYCGYLDFKYETVKDKLFDPARSDENKLRWRSDVDTVEKMLRGVDRHAFQVEGLVKEYRSTYGEKEQLLEMMGLDSSSRYKAGREVLPAAMASALRSNAVYCIHSIIDWLVVLGYAEGNYADLRFNRPGDGYARNWSLTLPLSLEELLEDRLVGPVKEVVDDGLGVAAREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLC8</accession>
    <name>A0A398CLC8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_20765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03225">
        <property type="protein sequence ID" value="RIE03225"/>
        <property type="gene ID" value="D3H35_20765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="56"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="278" mass="30463" checksum="D5136A0A4C4E941D" modified="2018-12-05" version="1">MIAVTVVTLYPFLNVLALSLNDSVDSVRGGITIFPRDFTLENYKLIFSFTGLITGFKISVLRTVVGTILGLISASMLAFTLARPDFQGRRFVSVFLALTMYVSGGLIPGYMLIKDLGMMNTFAVYVLPGLVSAFNVFIIRSFIDGLPYALQESAKIDGANDFTIYWRIILPMTKPALATIALFLAVGQWNSWFDTYLYNGSNDALTTLQFELMKVLQSTSSGNGGDIHGSNMGQVMATVSPESVKMAITIFVTLPILLVYPFLQRYFVKGMTLGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLW6</accession>
    <name>A0A398CLW6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_13805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01858">
        <property type="protein sequence ID" value="RIE01858"/>
        <property type="gene ID" value="D3H35_13805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="33"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="187"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="381" mass="42515" checksum="AC07D56A15A88E19" modified="2018-12-05" version="1">MNILMICTEKLPVPNIRGGAIQTYIGGISGILSRHHRLTILGRSDPELPAEEAADGVRYVRVDSDGLLNVYTQGVVEFLARSQEVYDIIHIFNRPKLVLPVRQFAPAARIILSMHNDMFSPEKLSRAEGVAVLENTERIVTISNFIGSSICRYYPEAAPKIRTIYSGVDLSRFAPWLESDFARQARQTIRSQHQLDSKKVILFVGRLSRNKGPHVLVRAMSQLKHPDAALVVVGAAWYSDDSVSDYIAYIRAIAARSKIPVVTTGYVPAHEVHQWFCAADVFVCTSIWDEPLARVHYEAMAAGLPFITTARGGNPEIVRDNNGLLVQNPEDPLEYAGALNHILSDLNAARQMGIRGRRMIENHFTWEHVAGNVLSVWEQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM78</accession>
    <name>A0A398CM78_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription factor FapR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Fatty acid and phospholipid biosynthesis regulator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">fapR</name>
        <name evidence="3" type="ORF">D3H35_07685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FapR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04456">
        <property type="protein sequence ID" value="RIE04456"/>
        <property type="gene ID" value="D3H35_07685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01814">
        <property type="entry name" value="Transcrip_fact_FapR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017275">
        <property type="entry name" value="Transcription_factor_FapR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037733">
        <property type="entry name" value="Transcription_factor_FapR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="116"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="201" mass="22807" checksum="CD60CE550A8600E9" modified="2018-12-05" version="1">MERLPKRQRHQQLSRLIEENPFLTDRELTRLLKVSIQTIRLDRLELAIPELRERLKAMAERSYDSVRSLPLHEVIGDIVDLQLDKSGISLFEIREEHVFSRTGIARGHHVFAQANSLAVAVINDEVALTSSADIRFIRPARLGEKCIAKAYVRSSGEQKGKAKVEVFTYVGEEMVFTGNFVIYRSTALGEREGAGRHADSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMN6</accession>
    <name>A0A398CMN6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04626">
        <property type="protein sequence ID" value="RIE04626"/>
        <property type="gene ID" value="D3H35_03800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="205" mass="22965" checksum="C51C045E62AE0CCD" modified="2018-12-05" version="1">MPPLYGAGFLWIAASVLWWSGWREESEDRLPDRAAAVFLAGWPLTAWWSRQVEPGVTINGAFAWAGIAMLVLLWRLSSGRRWTAVAAGMMIGCLFVLLEKWPAFERNGFDPSEPWPLALLGGVLLGFLLRTASEQIVALTAALILAEGFAALPLRESGYAIIGNAEWMERWWIALLSARLWSWLAAAFVRWFWNPSWNKDGGRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMR3</accession>
    <name>A0A398CMR3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03755">
        <property type="protein sequence ID" value="RIE03755"/>
        <property type="gene ID" value="D3H35_09360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="120" mass="13713" checksum="FC5B14B4D44D425A" modified="2018-12-05" version="1">MSEHPWILATEPSPDARNVPSEMHISIHFKEDMSRHTLNARNILILDGMDGGRLISNRFAYRYHAEKNMLQIYFKDRGDGFACGNDIEVILTGRIANASNVTMDIPYSFHFSTASRLRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMU9</accession>
    <name>A0A398CMU9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copper amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_29880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00244">
        <property type="protein sequence ID" value="RIE00244"/>
        <property type="gene ID" value="D3H35_29880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029410">
        <property type="entry name" value="CAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14504">
        <property type="entry name" value="CAP_assoc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP_assoc_N" evidence="2">
        <location>
            <begin position="63"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="215"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="334" mass="36611" checksum="9048528958776E47" modified="2018-12-05" version="1">MQRSLSRITMRIGKWGLLTLAATFLLGFAAPYPTSTYKVLAAAADSTTKPLTEKLFPIRGITIGTTEKTLIQKLGEPNRKDPSEYGFTWFVYNKDYKQYAQIGVAAGRVVAAYSNAAGVKSNAGIAIGTTRKDAEAKLGKPLTTLKIGNTTWKLNDGKELGRYTVGTGIVTLFYDIHAKNTVTSMLVMDKKTATTATATVKNAKLQAAYERELFDLANSVRVRMELAPFKWDDTAAKTARLHSADMAARKFFDHENPDGKSPFDRMEKQGIAYRLAAENIAAGQDNAIFAHESWMNSAGHRKNLLSAIAKFGAGVAFGGEYGIYYTQNFFTPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMZ4</accession>
    <name>A0A398CMZ4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_25665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00951">
        <property type="protein sequence ID" value="RIE00951"/>
        <property type="gene ID" value="D3H35_25665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017439363" evidence="2">
        <location>
            <begin position="38"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="538" mass="59318" checksum="B30C3634F1F9C07D" modified="2018-12-05" version="1">MPLVTSTPAKALRLIAVVPSLLALLLGCSANSTSTKAIPPIKAVDNLAQKKTIVSSPNSPSPSLVPRQSPSPVPIPTEKADVVLIGSELEGMYLARAAADEGLVVKTIDPRDQPGGQLLQAEMQFLDAVVDNGGKGKLIAQGRVKELITGFRKGTIRKPSEFTAYYNKLVQGIPIESGIQIQDVERVPGLRGESKIDSVTYKSKNGSLHRIEADYWVENTDYAALVGKLGVERQPGLEAFFGAKQVEYMSAGLMMKFKNVDWDAFQKHGYTTVDANYGVGVVDVTKRYVSSNDRVFLRGLNAVNQRDGEVLVNALLVYQIDPSDERSIEEGMALGRQETELVLQHFRQSMAGWEHAELNGFPHSLYIREYNHYNADYNLQVSDMLSGHMFFDNVSIAGYPLDLQGLRHAKWGTEMGRPDKYGMPLRSFLLKRYENVILAGKNVGTTAIAYGSARIQQNTSIAAESIGAIIGHLRGAKKLKELQAGDWPELHRFLNANYHIKLSGIVAKNKLAGWTTEEIDRLNEGKINYTIFERTGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN91</accession>
    <name>A0A398CN91_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RidA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04826">
        <property type="protein sequence ID" value="RIE04826"/>
        <property type="gene ID" value="D3H35_04995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="131" mass="14351" checksum="C7986AFB55FE4D50" modified="2018-12-05" version="1">MSRRTQVSTGSPWEPIVGYSRAVRVGNQIEVAGTTAMKDGEVVGEGDAYAQTVHILEIIDAAIRELGGQLKDVVRTRMFVTDMSRWEEIGKAHGEAFGDIRPAATMVEVKALIDPRLLVEIEAQAILTEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CND1</accession>
    <name>A0A398CND1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_09725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03822">
        <property type="protein sequence ID" value="RIE03822"/>
        <property type="gene ID" value="D3H35_09725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="287"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="461" mass="52645" checksum="E185F30008FA8555" modified="2018-12-05" version="1">MNILHVSLGLPPYRTGGLTKYSVDLMLAQREARHEVSVLYPGHFAIGSLSIKPNAEFEGIRVYEIVNPLPVSLLGGVRQPSRFYNAVERKPYEDFLSKLNPDVIHIHSLMGVHYEFFLAAKKRGIKLVFTTHDYYGICPKVNLLNRDESICNDYGDGLGCAQCNGTGYSMLKLYLMQSRTYRHLKNSPFVRKMRQREKSRQTIAASRPIAPGDRLEEEKRAPEFVRLRKYYLDILSLVDTFHFNSSIAKEEYNRHMDARGTIIPVTHRDIRDSRTVKRRANGGKLVRLAYLGPVDKYKGFFLLKESLALLSHRKDWILDVYGNSSIDSDDYDPVRFAFHGSYSYGDLSRIFDRTDLLIMPSIWKETFGFVGLEAFSYGVPVMVSEHMGFKDVVSDGETGIVFGDGAARLASELERIMDNRELLSAMNRNIVQMDFPFSMERHAAQMMELYGEMGVAGRRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNE5</accession>
    <name>A0A398CNE5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_08655</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04015">
        <property type="protein sequence ID" value="RIE04015"/>
        <property type="gene ID" value="D3H35_08655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017304180" evidence="7">
        <location>
            <begin position="28"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="8">
        <location>
            <begin position="63"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="298" mass="32446" checksum="8BF75E6B496AE374" modified="2018-12-05" version="1">MKKGLFLSIALLLVLAIAGCGSKNNEASSSPSESKAASPSASADASPSASAPASSEKPAEVKKILVGTTSLFPQVCFLDANGKLTGYDIELVREIDKRLPEYEFDFQLLDSMPSLLLSLETKKVDLVAHEIEKNAEREEKYLFNKEPYAHWKNKIVVAKDNNDPIETLDDAKGKKFLTSASSAADQILKNYNKDHNNALKIVYQSGGANDTVEQISSGRVYGTLAADFTLSLIDPEGKLKTVGKALSQADILFLFRKNEPEQQTLADAIDKVLVEIKADGTLSKLSKEWLGQDFTTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNZ0</accession>
    <name>A0A398CNZ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_22950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01251">
        <property type="protein sequence ID" value="RIE01251"/>
        <property type="gene ID" value="D3H35_22950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="PTHR11364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="15"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="164"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="278" mass="30587" checksum="A35AA8C8F65B4461" modified="2018-12-05" version="1">MKSIVSLKWLLARMYEADLVIADCRFQLGKPDAGREAYEESHIPGAVYLDLEKDLSAPVGEHGGRHPLPDIEALVKSLSKAGIGPDTRVVAYDDQGGAMASRLWWLLKYLGHDNAYVLDEGFSAWKREGFPISSEQKVLIPAPFVAEVRPDLVVGMEEVRRKKSEPGVVLIDSREAPRYRGEVEPIDKAAGHIPGAINRFWAEGRRADGTWKNADEQAERFADLPRDAEIIVYCGSGVTATPNVLALEAAGFENVKLYAGSWSDWISYSGNAIAFGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP93</accession>
    <name>A0A398CP93_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Shikimate kinase</fullName>
            <shortName evidence="10">SK</shortName>
            <ecNumber evidence="3 10">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aroK</name>
        <name evidence="11" type="ORF">D3H35_07025</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="3 10"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04345">
        <property type="protein sequence ID" value="RIE04345"/>
        <property type="gene ID" value="D3H35_07025"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE04345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="174" mass="18977" checksum="1F0CEE3FA3F3046F" modified="2018-12-05" version="1">MSGNAGKSNLILVGFMGTGKSTVSRMLSESLGWPRFDTDEEVERRSGKTISELFAEEGESSFRDWESRALADVLSGTNRIVATGGGAVLREENRRVMRLGGWIVALTADKESLIRRVTAGNADGTRPLLAGDAEARVASLLETRKHAYDFAHAVIDTSRLSPADVADLLQRWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP94</accession>
    <name>A0A398CP94_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yidD</name>
        <name evidence="2" type="ORF">D3H35_26540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00754">
        <property type="protein sequence ID" value="RIE00754"/>
        <property type="gene ID" value="D3H35_26540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00386">
        <property type="entry name" value="UPF0161_YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="83" mass="9324" checksum="CCA7D09ABDDBD8A4" modified="2018-12-05" version="1">MKVRRALQIPVRFYRRFVSPLKPPTCRFYPTCSEYAMEALEVHGALKGSYLAAVRICKCHPFHPGGVDHVPPKSGKDRGGRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPC4</accession>
    <name>A0A398CPC4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH LytTR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00784">
        <property type="protein sequence ID" value="RIE00784"/>
        <property type="gene ID" value="D3H35_26705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH LytTR-type" evidence="1">
        <location>
            <begin position="32"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="111" mass="12739" checksum="AD5C09746FA88D9B" modified="2018-12-05" version="1">MMNVALEEKNVYEDFEPRSDTLFFKVGSHGLISFHGRNYNIKKKLSAEERNRLLSDSNFYRVASDCYVNVGKISHIEEDGLHFGNCTKSVSCSKRVQHYVMQMMQGSPRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPC9</accession>
    <name>A0A398CPC9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_06395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04242">
        <property type="protein sequence ID" value="RIE04242"/>
        <property type="gene ID" value="D3H35_06395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017267411" evidence="2">
        <location>
            <begin position="30"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="360" mass="41040" checksum="0EDEEDE2F8F69C46" modified="2018-12-05" version="1">MHRLVWTAAVLVLLIAAVAKTAAPMPVYAEPLPEETRRLLEKSLSVYEIDREIERITKLHTQTERQIEQSKSRLDQQEIAVAVQREQAGRVLRSIYMGRQQFWLTSVMSVKSLSELLRLWEAMDLVISSDRKKMNAYSEQYSKLLEGYEQLRKDQTELAAVVTDLESQRVRVAALQDEVAGALAGRGDADHLRALMDELQNYWDNVGLYEVKQHFRALAGAMKKLPAWVKEHPEALETKGLAAKLTITDTELNDFLRGEDSRFDSFSFKFDDGLLILDGDNGDMRVRIEGAYTVENEPVNGILFHVRKLVFNGLELPDTTRADLEREFDLGFYPQKLIKFVKAESVELEDGKLIVKLKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPD9</accession>
    <name>A0A398CPD9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 7">Transcriptional regulator MraZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">mraZ</name>
        <name evidence="10" type="ORF">D3H35_06445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MraZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04252">
        <property type="protein sequence ID" value="RIE04252"/>
        <property type="gene ID" value="D3H35_06445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01008">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00242">
        <property type="entry name" value="TIGR00242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="5"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="145" mass="16751" checksum="D01B79DB6AA77C2C" modified="2018-12-05" version="1">MFLGEYQHSIDDKGRIIIPAKFRDALGSDFIVTRGLDSCLFVYPREEWTQLEQRMKALPSMAANARAFSRLLFSGASECEWDKQGRVNVPGHLRDYAKLDKDCVVIGVSTRVEIWDKKAWEEYSRASQDSFNEIAEKLVDFDFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPJ1</accession>
    <name>A0A398CPJ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5'-3' exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_09050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04080">
        <property type="protein sequence ID" value="RIE04080"/>
        <property type="gene ID" value="D3H35_09050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038969">
        <property type="entry name" value="FEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646">
        <property type="entry name" value="PTHR42646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="53EXOc" evidence="2">
        <location>
            <begin position="7"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="295" mass="32971" checksum="289D6B19A97437A4" modified="2018-12-05" version="1">MIRESNDNGDAVLLVDGMALLFRAYFASAYGGGPVKRTRDGVPVNAIHGFLRYLADAVKKIRPTHLVCCWDLGGQTFRAQRYDSYKGNRPEAPEDLIPQFGLIKDVVESFGILNVSAEGYEADDCIGTLARRFAADAHVYVLTGDHDLLQIVDERISVVIMKKGHGNYQVYTPDFLMEERQMTPAQIIDMKGLMGDTSDNYPGVRGVGEKTALKLILEYRSIDGILSNLESLPKTLRGKIEADLDMLRLSRELATIHCEAPVTVEFAECLWCVDLDRVKTMCETVEFKDSIRWIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPS7</accession>
    <name>A0A398CPS7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carb-bd_dom_fam9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_05520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04553">
        <property type="protein sequence ID" value="RIE04553"/>
        <property type="gene ID" value="D3H35_05520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010502">
        <property type="entry name" value="Carb-bd_dom_fam9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06452">
        <property type="entry name" value="CBM9_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017376528" description="Carb-bd_dom_fam9 domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="domain" description="Carb-bd_dom_fam9" evidence="2">
        <location>
            <begin position="1491"/>
            <end position="1654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1839" mass="198990" checksum="611E8C20E7ED7A73" modified="2018-12-05" version="1">MLTRKKGVYWALVIALVFGLVPAYPSIALADDGPVPLFAEDFAAPGSHWDGTAWSVEQDADTGSAAGKLTSSSGAYPTSRVKPAVWTSYAATNDNYKLEFKAKYSDAAAGAPKYFRVFFRYDTTQTGVNHYYFEFRQGGNLVYFGKYVNGVDTRIGNGYTISDKIAGFSFQSWHQYEVIADGAVFRIAIDGVPIGKTESETTHARGTVGFGLKNAVLSVDDVRVTPFHEEPPIEITHTPIASAYYNTDAPGAFTVPAPAAGVAVNAVVSYRYGTESYRTIDLPPSTDGAFSFVIPGTNRASAIGYYLTVTDSAGHSGRYPASGEQTIAVKPFNRFFDNFESTPAGQLPVDWFLRGIQPNIAVYDDGGNHVLRFAGAATGNNWTAKFVNPLYRNIDHFKVSFRAKYKVTNPDPHELYNVWRLSYRDKDTFYNTMEWGSHNTKYIMFKRTPLGGVDNGSYYRSVPEEWHRYEVEVAGITHTLSIDGQTVIRFDDASEDAPDKGFLQFTTVNGLELLIDDFEITPVTVPYVYNVEPYGNFVGIYESGEPLGLTASVQAGAAEQTYRVSYRVTRADGAKEEVAAGQREFTVPAYEKRSEAILFEPNVAGFGVYDVTSELYINGVKADDKTKTLRVAVIKQAAAARTSDLSMESKFGFNINYDLATKDDLIDSVRTMGVRHGRFGLAWPGIDTNGGIYNYEVYDPIIDAFASRGINPIPILGIKSNGVYDNGEVVDNRGGLEALRSFMADLVQHYEGKVRYWEMPNEPELETHPYIPQELVQVQKAAYSAMKKTDLNAVLIAGAHTSGVTQILPGELELGSYNYADAFSYHRYTYGVMPDGFVQKQYEGVRKLIDGYGGWKDLYVTESGWPTATNGYPSVSQEVQRDYAVRGFLIDMISDQVRALEHFNWRDSGFDANFYNTNFGITDGNGRPKLAYPALQTLMTTLDRARYVGTLQTGDESVEAHLFLNGNEPVLVLWKKVNYGGALVASAPKSTIALPVDSAQVTVIDVYGREASIAASGGQATLTVSGTPMFVKGFGAALTFASAGQLQAKKKTEAAAKLEALRTGGNGAAIDGALGELNRIHGALASALSSAQPAGRSAGIEQGAKDLYALMTRVANLIRDGAVDRVKGDVALEALYNDAEYAATALIEAKRQEGGQPQPAIPDYGSAVAEARSAYDGKIGPNGLMPVSTSAMMRANRYAEIAAKSASEGYAFDAYGYGVMAKELAQVVEAIVESEPVIPVDVTMSASPVNGEIESGGSLPVIVSLTNRSSQTKTVTLNLAVPSGWGAAQTEQATRTVTLAAGAAQDVNLALQAPIDASPGIFYAQLDLAIGGVPSDLIKIKLNATSAVRARLMPVAKSPGELDIVNVRLTGTSQAPKSGKVILKGPDGQTLEPVVPGGDAYSIVYGQTVDVPFKWTYGRTRPFHEYVGSLEVTDQSAANRVIYRDAAVPLDFLIVQKAKPTLAIDGDLSDWIDAYPIHMRGAERNANGVYEPNNLDAVMYAKWDESNLYFALEVTDDIHKAAEPPSGIWKNDAVQFAIDPLNDKGGTYRDDDIDFGLALNDFGQQLGFVFQAQPPNATGDISSAIPYRIVRDEAHHKTYYEAKIPGDSIVKALGSRLHLGGEIGFNAVVPDSDLQDGRQNYIGWTKGIAESKNPGLYDTFTFVDVPFALPDETPPAIVITPIGSIAQTQTLLVNVAATDLQSGISQVKATIDGKPISVPVKITPLSLRIGTHTLEVRAKDAAGNEAVQTAVFTVTISLGLLDDVIGMGAAKGWIKGDAVTILLLAQAAVIQRTEKNRADNLKSLRLQVELLAAAKKIDAAFAVMLKEDLVFLENLYRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPW0</accession>
    <name>A0A398CPW0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_24365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01491">
        <property type="protein sequence ID" value="RIE01491"/>
        <property type="gene ID" value="D3H35_24365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="5">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="218" mass="23904" checksum="21129629CE672F03" modified="2018-12-05" version="1">MNPEQPLRIVIVDDHPLFRHGVTTLFSTMPDLEVVGEAANGEEAVALAEALKPDVMLMDIRMPGISGIETTRRITTASPSVKVLILTMFEDDASVFTAMRSGAKGYVLKEADKDELLRAIRAVANGEAIFSPGIASRMIEYFAMTRPAASEEAFPELSSREREVLYLMTDGISNADIAGKLEISGKTVANYITNILNKLQVADRQEAVRLAKESRLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ99</accession>
    <name>A0A398CQ99_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04632">
        <property type="protein sequence ID" value="RIE04632"/>
        <property type="gene ID" value="D3H35_03830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="97" mass="10836" checksum="ACF365EEB54C5948" modified="2018-12-05" version="1">MITLTGRTRTKSLEPMIGQSLLAHALKAEVDFGFNCSRGTCARCRCRVEEGMELLAEPNDAEWDRLGPEELEEGYRLGCQAIVAKEGILKAVNRTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQE2</accession>
    <name>A0A398CQE2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DnaD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04692">
        <property type="protein sequence ID" value="RIE04692"/>
        <property type="gene ID" value="D3H35_04185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034829">
        <property type="entry name" value="DnaD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006343">
        <property type="entry name" value="DnaD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07261">
        <property type="entry name" value="DnaB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158499">
        <property type="entry name" value="SSF158499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01446">
        <property type="entry name" value="DnaD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaB_2" evidence="1">
        <location>
            <begin position="168"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="247" mass="27388" checksum="784D4D71DB53F618" modified="2018-12-05" version="1">MNDRNGLARGLMEAYMEGSVSIPYAILRTYRALKLSDTEGMLLIHLLAYRQLEQNEFPTIEQLQERIGSSPSVVGQAMQKLVKQGLVSIDEVLDPVTGVQSDRYNLTGLFQKISVLLAAGELPIRAGGVAELSSASGAGEPQDRVYLPKAQTTSNTSAYGGAANLFGVFEQEFGRPLSTMEVETISGWLDQDKYSEELILFALKESVFAGKIHFRYIDRILLEWSRNRVTNAEEARAYSQKFRGGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQL2</accession>
    <name>A0A398CQL2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_04975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04823">
        <property type="protein sequence ID" value="RIE04823"/>
        <property type="gene ID" value="D3H35_04975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="195" mass="23208" checksum="047999C4D6A12D23" modified="2018-12-05" version="1">MSAALTYEELVVPHLEDLRKYCYFLTNSKWDGEDLCQEALLKSLIYFLHSEPRLDVKPFLIRVARNLWIDDCRAKKRRQRAGLHHFASCYTDTNYAEVRGTMEWLSERLPSRNIEMWLLSEYFGYTMQEISDELDSSVPAVKSVLFRTRGLIRMHKELSQRKETKDRKPPRQAVNWEVERWSRAVIADRPHMILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQL7</accession>
    <name>A0A398CQL7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein NrdI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">nrdI</name>
        <name evidence="4" type="ORF">D3H35_05100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Probably involved in ribonucleotide reductase function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the NrdI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04845">
        <property type="protein sequence ID" value="RIE04845"/>
        <property type="gene ID" value="D3H35_05100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00128">
        <property type="entry name" value="NrdI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020852">
        <property type="entry name" value="RNR_Ib_NrdI_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004465">
        <property type="entry name" value="RNR_NrdI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37297">
        <property type="entry name" value="PTHR37297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07972">
        <property type="entry name" value="Flavodoxin_NdrI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005087">
        <property type="entry name" value="NrdI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00333">
        <property type="entry name" value="nrdI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="119" mass="13175" checksum="298DA0459CB7EE6D" modified="2018-12-05" version="1">MLIAYDSKTGNVRRFVNKLNLPSVQIDESMTVNEPFVLVTYTTGFGQAPDKVLHFLERNHGKLMGVSASGNRNWGEGFARSADRISEKYGVPVICKFELSGTTKDVERFVKEVGAVAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQR8</accession>
    <name>A0A398CQR8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02167">
        <property type="protein sequence ID" value="RIE02167"/>
        <property type="gene ID" value="D3H35_15580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="139" mass="15644" checksum="3E80013271F4E7B5" modified="2018-12-05" version="1">MEKHEMVLVSAPNIAGESFLKLLQRKSIPYAVIVNNKTEYERIAELGAPNIIVVNTTKENSWVVPEASIGKVYLFEKSLNLCCRYIQICRSWTRKPIYVVTGSHNPRLVYKGLGADYVIHSEGPDFTFLIGDDIGSRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQS2</accession>
    <name>A0A398CQS2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphodiester glycosidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_15755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03148">
        <property type="protein sequence ID" value="RIE03148"/>
        <property type="gene ID" value="D3H35_15755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="NAGPA" evidence="3">
        <location>
            <begin position="207"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="414" mass="44564" checksum="40F2F0BDD71245A0" modified="2018-12-05" version="1">MITLPYVKCEAAIERSVDAIPPNTNPTPSAARSGQPASSPVGSRTSRSRQTRRRRKSFVWTLAKAGFWTGLLGTAVFAVWFFLTPSGNEFRYMMADSLITTQHRHWAKYIIGEKGLKERVALYVQRFDQMGEERDLHTIAPDPGSGTGEEAGGLGNENAPLTSVEEIDGAGYHGYLLTVRDPKKIRLVVPIKADKGEKVSSMVKRTGAIAGVNAGGFADPNWKGNGFKPIGLVISHGQIYYNGLGKAKSTQIVGIDKDGKMLAGRYGIQELLDLGISEAVSFSPRIIVNGKGLIPSKEQGWGIAPRTVMGQREDGAILFLMIDGRQPGYSIGATLYDAQEIMLAHGAVIAANLDGGSSTVLVNGQGEVVNKPSSQYGERYLPSAFLVFDDPDSVSVPNVWAGLKPEDIDAGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQS6</accession>
    <name>A0A398CQS6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-layer homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02177">
        <property type="protein sequence ID" value="RIE02177"/>
        <property type="gene ID" value="D3H35_15660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="59"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="211"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="445" mass="50397" checksum="E517339BCC2E0449" modified="2018-12-05" version="1">MPARIVVSSDFNSPRMWLAIFCRIESKNLQRRRIMRRLTAVMTMVALLWTGSNAYASADAASPFSDIRGNWAENTIKDMVARGVLDGFADGKFRPNDPVKVDQFIKMLILSYADLHQNKERSWNETFLSSLSEDNRMILKQDYRYFDFKPSTSGFWAKPFIDVASDLHFLNKSRYSDFQANMTRENVAEVLYYTLQETEFLEDEQFSEQAAKAYGDLTSATDRERKFIAESLVKGIMVGYDNGNFGVGKIVTRAEALSLLERLTNKSKRVPIKASPEKLQRQVPTQGGGSKIVAFPDKRMWDAYDVLVQIGKVRGLNQDMLETKLRLFKDQTEKDAVQSQTAGTAKATEEATLWLDPQYNTYGITMRLRSGTFARNQESVQTFANYLFGYNASTFYPLFNSVCTDTEAGKKVESKRVVIGGDTVDIQVDAANKTVVFSISKKLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRC2</accession>
    <name>A0A398CRC2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAA hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05093">
        <property type="protein sequence ID" value="RIE05093"/>
        <property type="gene ID" value="D3H35_02885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="91"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="297" mass="32233" checksum="772F4530EB0EE8F0" modified="2018-12-05" version="1">MKLLHYREDGKIKLGIATVHGVVDVEAAVGGEAAPELKSADAALAAGGEALDRLRELDRRIAEEGPAAFKESLRNEAELSLEPCVVRPGKLICVGLNYRRHAEETGSPIPAYPILFNKFDNALSAHGRDIRLPKTSDKTDYEAELGIVIGRTAFDVAPEEALDYVGGYCNVNDVSARDLQVRTSQWLLGKSLDGFCPIGPYLVTADAVPEPNSLGIRCTVNGELRQSSNTSDMIFDCRTIVSYISRHMTLQPGDLIMTGTPEGVVLGYPEDRQVYLKTGDIVTVEIDGLGSLTNRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRD7</accession>
    <name>A0A398CRD7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3243 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_11725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03348">
        <property type="protein sequence ID" value="RIE03348"/>
        <property type="gene ID" value="D3H35_11725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021637">
        <property type="entry name" value="DUF3243"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024702">
        <property type="entry name" value="Uncharacterised_YmfJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038292">
        <property type="entry name" value="YmfJ/YflH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11588">
        <property type="entry name" value="DUF3243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004764">
        <property type="entry name" value="YmfJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="84" mass="9555" checksum="AB32D2B85CC94214" modified="2018-12-05" version="1">MSTVLGNFDTWKKFLGDRVEAAKKLGIGEDAIAKLAYEIGEFLDQKVDPKNDEQRILKELWDIGDESERKTMARLMVKLADHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRK9</accession>
    <name>A0A398CRK9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="9">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">asnB</name>
        <name evidence="9" type="ORF">D3H35_08050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="9"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03909">
        <property type="protein sequence ID" value="RIE03909"/>
        <property type="gene ID" value="D3H35_08050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="380"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="618" mass="70360" checksum="8183DE82A8039B8C" modified="2018-12-05" version="1">MCGITGWIDWQEDLTKRADTIEKMTDTLELRGPDASGTWLSKHCAFGHRRLSVIDPANGAQPMIRPVKQAEDQDCVVVYNGELYNAPELRKELEALGYRFRTTCDTEVLLLAYVEWGPACVDKFNGIFAFAIWRTDEEKLFMARDRLGVKPLFYRREEGRLLFGSEPKAILAHPDVSPDIDAEGLAELFVIGPARTPGHGVWLGLSELKPGHCLVYDRNGMKMTTYWKLESRDHEDDLETTAEKVGELLRDTVERQLVSDVPVGTLLSGGLDSSALTALAVRYYDKTGQDQVHTFSVDYVDNDKHFKAHDFQPNADAPWIERMSGYLATVHHPVQFDTPELVDALQAATLAKDTPGMADIDASLYLFSREIKKKATVAISGEAADEIFGGYPWFHREEALQAETFPWSLAVGLRASLLSPELREKLRPQEYLSDKYAEAIGEVPHLPGEDQVQRRMRRMSYLNVTRFMPTLLDRKDRMSMAAGLEVRVPFCDHRLVEYVFNIPWEMKTAGNREKGILRQSLEGVLPHDVLYRKKSPYPKTHNPHYFQSVRSRLLDRLEDPSCPLHPLINVDRIRELALASDAGSHLPWFGQLMSGPQLFAYLLQMDFWLRHYRVNIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS33</accession>
    <name>A0A398CS33_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF948 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_18160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02607">
        <property type="protein sequence ID" value="RIE02607"/>
        <property type="gene ID" value="D3H35_18160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009293">
        <property type="entry name" value="UPF0478"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06103">
        <property type="entry name" value="DUF948"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="180" mass="19165" checksum="6923B237C5D5A097" modified="2018-12-05" version="1">MVQRLPLAGNGTLDRHKPTPVQPEGGMLLSSNEIIAWSVAAAAASFMALCVFLILLLRATQSAMREVKMTVESLQGDVKKLAATVTEVTDDIRGKLQSTDPLFDAVKDVGELLSEATGAARHASRGIAHAFNLQAAAATHQADDAPTPAWLRWATIGARVAIGLRKGWQQSRTSPADGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS58</accession>
    <name>A0A398CS58_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myristoyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_02575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05040">
        <property type="protein sequence ID" value="RIE05040"/>
        <property type="gene ID" value="D3H35_02575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528">
        <property type="entry name" value="PTHR31528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017417660" evidence="2">
        <location>
            <begin position="31"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="3">
        <location>
            <begin position="83"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="365" mass="39558" checksum="086BF7ED66A4B3D3" modified="2018-12-05" version="1">MAKKPIIVLILLLAFASIAAACGNKSNSNASPSPSASPSNSAPASTESPSPEASPSPSSATSDQIAKANETTKVTQVLDWFAQPTHGGFFAAQKTGFYKDANLDVTLQNGGPQVSAVQIVASGSADFGLAGADALLLAREQGIPVVALGAVLQISPSALFYHKEDNIKDFSDLNGRKVYAVLAATYWQYLKDTYKLDKVQEFQFNGQYANFISDPKAVSQGYVTNTLASLESQGVETGHLLVADSGYRPYYTVIFTTEKYAKEHPDVVKAYVEATVKGWNYYKDNAPEVNAEIVKVNQGAKVEDFNKEAEAQKDFVYGHDAAQNGVGYFTKERWEELNKQLHDIGILKKDEDVTKAFTTEFLPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS65</accession>
    <name>A0A398CS65_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_00495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000005">
        <property type="protein sequence ID" value="RIE05445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05445">
        <property type="protein sequence ID" value="RIE05445"/>
        <property type="gene ID" value="D3H35_00495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="82" mass="9267" checksum="15AABA0B334E161F" modified="2018-12-05" version="1" fragment="single">MKVNKLGAILVSPSILFLSVILIIPLFYTIYISLYDMRYLQMGDFVGLKNYIKVFTSDDIMSSMLITFIVTFVGLFISIVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS71</accession>
    <name>A0A398CS71_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02647">
        <property type="protein sequence ID" value="RIE02647"/>
        <property type="gene ID" value="D3H35_18385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="147" mass="16157" checksum="86E4359A1DA10D13" modified="2018-12-05" version="1">MKQLLVFVLFSALFCWLMFSPIYRHVLVIRQALLQQEADYMLEIGASGRYGYIDGGMIADSRSRLAETGFRSELLEYEVTTTTGAEGNNASAPLPRGVGIRLAISYPYGSLLSIDRLIGVEPPESDARLSAGGMKMSEYVPLREGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSB5</accession>
    <name>A0A398CSB5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02271">
        <property type="protein sequence ID" value="RIE02271"/>
        <property type="gene ID" value="D3H35_16220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="108" mass="11575" checksum="15D6204F1DAACB8D" modified="2018-12-05" version="1">MEEITGCSWDTGLADVRVEEITGCSWATELADARTEEITGCSWATGLADERMDEITGCSWATGLADERVVEIAGCSWATGLADERVVEIAGCSWAIELADERVEEIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CST5</accession>
    <name>A0A398CST5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02024">
        <property type="protein sequence ID" value="RIE02024"/>
        <property type="gene ID" value="D3H35_14765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043748">
        <property type="entry name" value="DUF5693"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18949">
        <property type="entry name" value="DUF5693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="551"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="608"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="657"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="695" mass="76136" checksum="3C28E7208C58F160" modified="2018-12-05" version="1">MESQVVHWLWWIVLVGVVAALPVMYARAQTESSANKVAVVVDYRDLLQVSSTKGEPEAFLDEQLAKLKEAGVNGMAVFESTLQELSWAGEVEVYTATEAALLEGKTAADAGNNRTYVMFTKPGDADTIRSMIDWAFKKHGFDVADWSYEGQKGVSIDMGIDDAMIRPMQPNPLEMDRLHAAGYQLYPRLSDRFSPYDRDEMKRWIESFEKYGVTRVLFDGEGVPGFSEPAKNKAIENLADLLKEHGMGIGAFENMKAPTKGLSSLAKDLDYNVVRAHSLSDGELAKLTVEQLQDRLFLAVKDRDIRLIYLHTLALRDSVKGKMTNPLEMIVDTLMGAEKSDDTDDTIDTSTVSEGTVEATALEREVGFIEKMSDFGFELGVPQAFDVHHAPAEKALRGLAMAGAIALVALMLGLFAPALLLPVTVIGYIGAAGLYVLAPTLMVQMLALFAAIAAPTVAVVLLVRKIRERRDAELSNGRKLGAALLLFVKTSVLSIAAVPLVVAMLNHITYSLVLQQFRGVSLLHLAPIALVAIYVFLYGSGDTVIGNARRILMMPVTFFWVVLIGVGAAAGMYYLTRTGNAGQVSGLELAFRSFLENTFGVRPRTKEFLIGHPLMLAGIFIALRYRWAMILLAMATIAQLSMVDTFAHIHTPLAMSIIRVLLGLGMGIVIGLIAVGVWRIIEKTWGRVEKYALDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSY5</accession>
    <name>A0A398CSY5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="4">G6PD</shortName>
            <ecNumber evidence="4">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">zwf</name>
        <name evidence="7" type="ORF">D3H35_01750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05270">
        <property type="protein sequence ID" value="RIE05270"/>
        <property type="gene ID" value="D3H35_01750"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 4" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="5">
        <location>
            <begin position="7"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="6">
        <location>
            <begin position="193"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="87"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="509" mass="57775" checksum="D5D494A0A2301A76" modified="2018-12-05" version="1">MEPTTFIMFGATGDLAKRKIYPALYNLYVDGKLPQAFTLFGLGRREWTDESFRINVEQSLHQFSRRGAKDAESVKAFVRAFRYSVLDIGREDDYRKLLKLVEGRENELSIPSNRLFYLSVGPEYFETIAANIQASGLGSANGWKRLVIEKPFGHDLRSARDLNRKLSQAFAEEEIYRIDHYLGKPVVQRMESLQQTNPVMQALWTNRYISNVQITALESVGVEERAGYYDHVGAVRDMFQNHMLQLLMMTAIHLPHDSSSEKVRFKKKKVMESLELVQKEDVGASVIRGQYSEGSIQGKPVVGYASEPGIAPSSMNDTFIAARLLIDNNDWRGVPFYIRTGKRMKEKSTKIVVEFKEPVKQPWMKIEEGIEPNLLVIEIGPEESITLQINTKEPGPNGGRFKPIRIDLQAGQADSPEAYENLIGDALNGDSTFFAHWDEVELSWQWVQPILDAFEENLVPLLPYEAGTYGPAASDALLAKDGNHWWFDAKPEPKSEVNEGERYAYNANH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT99</accession>
    <name>A0A398CT99_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-deoxyinosine glycosylase</fullName>
            <ecNumber evidence="2">3.2.2.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.15" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03057">
        <property type="protein sequence ID" value="RIE03057"/>
        <property type="gene ID" value="D3H35_20960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033958">
        <property type="term" value="F:DNA-deoxyinosine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026353">
        <property type="entry name" value="Hypoxan-DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04274">
        <property type="entry name" value="hypoxanDNAglyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="1">
        <location>
            <begin position="7"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="169" mass="19008" checksum="973142E5BE9D4B10" modified="2018-12-05" version="1">MSVQSFPPVVDERSRILILGSMPGTASLRIQQYYGNPRNHLWAILYGLFADRPPDAGYEDRIAFARSQGIALWDTIAQCEREGSLDSDIRDVVPNDIPGLLRQYPRVKTIVCNGAKSHAELLKHFGHTAEIAERKVLKLPSTSPIPTPKYRGLEERLEAWRIVKEAAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTP9</accession>
    <name>A0A398CTP9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Efflux RND transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000002">
        <property type="protein sequence ID" value="RIE05480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05480">
        <property type="protein sequence ID" value="RIE05480"/>
        <property type="gene ID" value="D3H35_00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="55" mass="5936" checksum="60DCAE5ECEB3CCC3" modified="2018-12-05" version="1">MLSSLLFVPIGAVLGLLIGNVKPDFTAIFGVVMLVGIVVTNAIVLIDRLDRTKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU35</accession>
    <name>A0A398CU35_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NINE protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_17395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02474">
        <property type="protein sequence ID" value="RIE02474"/>
        <property type="gene ID" value="D3H35_17395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="6">
        <location>
            <begin position="66"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="135" mass="14613" checksum="A4EAFA83EA507D4E" modified="2018-12-05" version="1">MSGRNCPSCGASIAVNAAECKYCGESLPVSQAPAPAPAPGPQYYQVPPNFQQPHAQYPPVPRYVATKSKVAAGLLGIFLGGLGIHKFYLGKTWMGILYLVFCWTYIPAIIGFIEGIVYLASSDIKFHSKYGKRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUA3</accession>
    <name>A0A398CUA3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_06600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04278">
        <property type="protein sequence ID" value="RIE04278"/>
        <property type="gene ID" value="D3H35_06600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="89" mass="10022" checksum="DC935AF8FECF0E0E" modified="2018-12-05" version="1">MNDGSFFSRSTSFNGGQPSVSTDRGIEWLIPDVRNGVSGMIFGKIRTLARTSRQLSIVRFLAYSFPSSTLHLFFLTLVILIAFRFVKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUJ9</accession>
    <name>A0A398CUJ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-grasp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_20370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02961">
        <property type="protein sequence ID" value="RIE02961"/>
        <property type="gene ID" value="D3H35_20370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040570">
        <property type="entry name" value="LAL_C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18603">
        <property type="entry name" value="LAL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="118"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="419" mass="46263" checksum="2ABAA1488F8FBD5D" modified="2018-12-05" version="1">MAHLLMIESWVGASGNLLPPLLHSLGHTYTFVTRKPEHYQSAHSTEKHPVVRYADSVLVAETNDSAGLIKLLQPYRFDGVITVCDYYIEIAREVAKAFSLPCPFPDEVKTVRQKHLMRQALDRAGLANPSYRLAHSLPEAEEAAAAIGYPLVLKPVDLASSAFVSLIRNEKELQDGYEALEAFPLNFRDQERDCTYLLEEYMSGEEVSVESVSYYGETAVLGVTDKSVTGTPYFIENGHMFPAKLSDEARTEVTQFVRDALKAVGFDHGIAHTEVKLTAEGPRIVEINPRTAGNYIVELIQRVTCVDLLQAFVELSLGKKPTIATKDDGMASAAVMFLVPPQSGTLARIQGLESLESDEHIVRYKVDNCEGRSIAAPIDNACYLGHVITQDREGSNARLYGEEALKRIILSFENKGAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUQ0</accession>
    <name>A0A398CUQ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_18925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02724">
        <property type="protein sequence ID" value="RIE02724"/>
        <property type="gene ID" value="D3H35_18925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="203"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="436" mass="49313" checksum="A43D2847D658DB92" modified="2018-12-05" version="1">MNSYRKTAAVLSVIAMGLGQIFNRQYTKGILLLFLYAGGLYYFVNNLGHALWGITTLGEKSQHLELVGKVYKMVPGDHSIFLIVQALIVLFALLLFIIAYIANVKDAYRVGKSREQGILPRNFIGTLQYTNQQKFPQLIIALPLIFVFFFTVLPLVFSILIAFTNYSSPKHLPPANLIDWIGFDAFKELFTLSKWAKTFYGVFTWNIIWAVLATITTFFGGFGVALLVQHSSTRFKPLWRTIYILPFAIPSFVSYLIMRNMFNSQFGPVNQYLKWLGIQGPSWLSDPIWAKATVLLVNLWHGYPISMLLIIGILTTIPKELYQAAEVDGASAAQKFRMITFPSVMFSLSPILIGMFAGNVNSFSAIFLLTNGNPANSEYQFAGSTDILITWLYNLTINQGNYNFASVIGIIIFIILATLSIWNFRRTRSFREEDVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUX2</accession>
    <name>A0A398CUX2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative regulatory protein D3H35_07310</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RemA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_027084220.1">
        <property type="nucleotide sequence ID" value="NZ_QXJM01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04388">
        <property type="protein sequence ID" value="RIE04388"/>
        <property type="gene ID" value="D3H35_07310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01503">
        <property type="entry name" value="RemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007169">
        <property type="entry name" value="RemA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38449">
        <property type="entry name" value="PTHR38449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04025">
        <property type="entry name" value="DUF370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="86" mass="9601" checksum="1F6BA4C026FEAD4D" modified="2018-12-05" version="1">MAIKLINIGFGNIVSANRIISIVSPESAPIKRIIQEARDRHMLIDATYGRRTRAVIITDSDHVILSAVQPETVAHRLSTKDDEHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV98</accession>
    <name>A0A398CV98_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05209">
        <property type="protein sequence ID" value="RIE05209"/>
        <property type="gene ID" value="D3H35_01425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="105" mass="11772" checksum="CA2EF62A1A336A82" modified="2018-12-05" version="1">MLKLFLKPLRILLGIYLIGSLSIASDIAQLTDFNILDVIKNHSPFSYYILITGTLFLYTILVIIEFARKNSSQATSTSNISIGQTIRTHNVKNSTIIQIKKDKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVA9</accession>
    <name>A0A398CVA9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AhpC-TSA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_01530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05229">
        <property type="protein sequence ID" value="RIE05229"/>
        <property type="gene ID" value="D3H35_01530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AhpC-TSA" evidence="2">
        <location>
            <begin position="24"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="154" mass="17438" checksum="56A5A6530C175F08" modified="2018-12-05" version="1">MRHADSQSIKTVKKTADTGLPLHDEVPALDVIDSGFRKFCVQEYIRGAKSALFFVSVTCIHCVDLLPYLSEIEEQRQFRILLFSAGEREDHEAMVDFFGWTFPVVSMNSSEMKALFQVEYLPFAIVANEQGIVSSKGVLYNANDFGLLVRHSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVB5</accession>
    <name>A0A398CVB5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NYN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03847">
        <property type="protein sequence ID" value="RIE03847"/>
        <property type="gene ID" value="D3H35_09860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12872">
        <property type="entry name" value="OST-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51644">
        <property type="entry name" value="HTH_OST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH OST-type" evidence="1">
        <location>
            <begin position="177"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="261" mass="29211" checksum="B4C7B92DCFE1F284" modified="2018-12-05" version="1">MSTIDERRLAVLIDADNVPYKNIKGIMEEIAKHGTPTIKRIYADWTAPTAAGWKSVLLENAITPIQQYGYTTGKNSTDSAMIIDAMDILYSEKVEGFCIISSDSDFTRLVTRLREAGMKVFGFGERKTPNPFIAACDKFTYIEIIHNPDRKASSDAGSEAKKENVAVKEHKHGTLPVGDEIIGLISASINDVDDENGWAFLAVVGNLILKKKPDFDPRNFGFAKLTPLIKSLKQFEIEERESGDSKIKHVYVRNQPIRRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVF3</accession>
    <name>A0A398CVF3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Lon protease</fullName>
            <ecNumber evidence="5 6">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 15" type="primary">lon</name>
        <name evidence="15" type="ORF">D3H35_07970</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 9">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6 9 10">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="5 6"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03897">
        <property type="protein sequence ID" value="RIE03897"/>
        <property type="gene ID" value="D3H35_07970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="14">
        <location>
            <begin position="11"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="13">
        <location>
            <begin position="593"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="774"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="190"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="680"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="723"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <begin position="356"/>
            <end position="363"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE03897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="811" mass="90460" checksum="4D16F0BE070E2C54" modified="2018-12-05" version="1">MGSGKPKSRSIPLLPLRGLLVYPSMVLHLDVGREKSVKALEQCMIDDHMILLCSQSEINIEEPTQDDIYKIGTIAKVRQMLKLPNGTIRVLVEGVMRAEIEQYLPNENFYEVLARELHEGKTNDSELDALMRAVLSQFEHYINLSKKVTPETMAAVADIEQPGRLADVITSHLSLKIKDKQDILETVEVRPRLEKLLDLLNNEREVLELERQISQRVKKQMEKTQKEYYLREQMKAIQKELGEKEGRAGEVEELRNQLAEAELPEKIHAKVEKEIDRLEKMPAASAEGGVIRNYVEWLLALPWSKMTEDDLDIAKAEAILEEEHYGLDKPKERVLEYLAVQKLVKKMKGPILCLVGAPGVGKTSLARSIAKSLGREFVRISLGGVRDEAEIRGHRRTYVGAMPGRIIQGMKSAGTQNPVFLLDEIDKMAMDFRGDPASALLEVLDPEQNNTFSDHYVEMPFDLSNVMFVTTANVVHNIPRPLLDRMELISIPGYTELEKEQIAERHLLPKQKRDHGLEPEQLDVKPEALRSLIREYTRESGVRNMEQQLASLCRKAAKAIVTNPDVAPIVVDLPKLKELLGPPRFRFGMAELEDQIGAVTGLAWTEVGGDTLVIEVTVMPGTGKLTLTGQLGDVMKESAQAAFSYTRSRVKELGIDPQFHEKNDVHIHIPEGAIPKDGPSAGITLATALISALTNLRVSREVAMTGEITLRGRVLPIGGLKEKSLAAHRAGIRKILLPKDNERDLKDIPESVRNELTFVPVAHMDEVLRHALSDPLPAQAANSAEEERNDMPPLGAAAESDAEDVPPLGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVH3</accession>
    <name>A0A398CVH3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron permease FTR1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_20605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03004">
        <property type="protein sequence ID" value="RIE03004"/>
        <property type="gene ID" value="D3H35_20605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="PTHR31632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017415831" evidence="7">
        <location>
            <begin position="36"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="503" mass="54891" checksum="3D1F0AC21CDD5B79" modified="2018-12-05" version="1">MKQTSRRTASAILLAVCVVLLTGTLFFFGPPSTSAAENDENISAVLIHSEQLQVSLESGQLEQAAEAFAPIKKWWNANKQAVKKNSLDMSSEIDRQIAAISLSLLTEDGAQALEQAGTLRFSLINYRDGAYLDNSGKQGMTLGVYVMKLRQAGNLMDAEKWSEARAQVKQLQQQWLSVEGDIVSQSQTVYNNSERDLVLLDAYLSSESKRTQAKPIVDRMIDSLTPFIDAQYSWWDAALIPIREGIEALLVVGALLMYAKKADSKPARKWVIGGSLSGVIVCIAVGFAVAVLFSSSAFGHNNSLINGWTGVLASVLLLYVSYWLHRNADTKRWKLFMETKSRQALSGGRMVSLALLAFFAIVREGLETVIFLIGMVGKMSAGELSGGIAAGFGVLALCAIVMVKAGTRLPVRPVFLVSSVIVFYLCFKFMGSGIHSLQMAGLLPSTVHDYLPEYASVSLYPSWYSTLPQLLFVLAALAVIVLQRTKVKRRSTILSNNKAPDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWG0</accession>
    <name>A0A398CWG0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metal-dependent carboxypeptidase</fullName>
            <ecNumber evidence="1">3.4.17.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_04530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of a C-terminal amino acid with broad specificity, except for -Pro.</text>
            <dbReference type="EC" id="3.4.17.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.19" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04898">
        <property type="protein sequence ID" value="RIE04898"/>
        <property type="gene ID" value="D3H35_04530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001333">
        <property type="entry name" value="Peptidase_M32_Taq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34217">
        <property type="entry name" value="PTHR34217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02074">
        <property type="entry name" value="Peptidase_M32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006615">
        <property type="entry name" value="Zn_crbxpep_Taq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00998">
        <property type="entry name" value="CRBOXYPTASET"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="509" mass="58246" checksum="FB0EFAE8675D10D1" modified="2018-12-05" version="1">MSEQKIGTRSELKRFRELAQQMKQYDEILGVVYWDMRTGAPRKGIGLRSEAVGALSSEIFRISTSDEMGQLLDTLSAPEQAEALSPVDKRLVEEQKKEYDRNKKIPADMHREYVVLSSQSESAWEEAKEKDDFEGFVPYLEKIIDYNRKFIDLWGVKSTPYDTLLDLYEPGLTTTELDRLFGELRSRLVPLAEAIASSDNRPDTSFLEGTFDKEAQKKFSRFILNEMGYDFEAGRLDESVHPFATGLSPGDVRITTRYLPHDVTSALFGTIHEGGHALYEQNIAEELAGTPLCTGTSMGIHESQSRLWENMVGRSRGFWQRYFPELQKHFPGQLDHVTAEQFYRGINVVEPSLIRIEADELTYNLHIMIRYEIERMIFNEGLEARDLPEVWNAKYKEALGLTPPTNALGVLQDVHWSGGAFGYFPSYSLGNMYGAQMMNVAKRKLPNLDERIAEGQLLPLKEWLTGQVYTHGKLLLPAEIIERVSGEPLRSTYLCDYLEQKYRDIYRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWI4</accession>
    <name>A0A398CWI4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03384">
        <property type="protein sequence ID" value="RIE03384"/>
        <property type="gene ID" value="D3H35_11950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="78" mass="8472" checksum="E48389CF669778F6" modified="2018-12-05" version="1">MNGGNEVTKITHNKPDSDFPTGLAKPAQRALANAGLRNLEQISHLSEEELNQLHGIGPKAVELLRQALRTKGLAFSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWQ7</accession>
    <name>A0A398CWQ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HD-GYP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_06530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04267">
        <property type="protein sequence ID" value="RIE04267"/>
        <property type="gene ID" value="D3H35_06530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="3">
        <location>
            <begin position="223"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="435" mass="48781" checksum="3C04F1DEF560B525" modified="2018-12-05" version="1">MFGVILTLSAYLLVTRQIVDETGAVTQSAVDKHFAVLPQLQRLFTDASVSQEAPFNRDATEGHNHEEASPATDEGNLPHNQLESIIRMHFDLYNIQDVVIYDLFGRVLFSYDDSRLNGQLTQGDRLPFKKAIEDGQRSASDQRGILHLWIPIQDSEGRTVGALEALRDISDRKSDSLGLIALLALLSLAGMLVLFFALRQLFIRSSRTIDSQNRELSEMVERIRRTYDESLQALSSALDSRDNETRGHSQRVTAYAWMLGKQLGLDEERMEWLIRGALLHDVGKIGIPDAILLKNGPLTEEEWVVMKGHVSQGVQMLRSIEFLGPSLDVVGYHHERWDGHGYPNGLQGEQIPLAARIFSVCDTYDAMTSDRPYRAACTHEEAILELQKNSGTQFSPAIVDAFLQISQEKLDSVRDLSKHQSLPFPLTSRDLSQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXH4</accession>
    <name>A0A398CXH4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YheC/YheD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_08120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03921">
        <property type="protein sequence ID" value="RIE03921"/>
        <property type="gene ID" value="D3H35_08120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026838">
        <property type="entry name" value="YheC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38437">
        <property type="entry name" value="PTHR38437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14398">
        <property type="entry name" value="ATPgrasp_YheCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="372"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="458" mass="52105" checksum="00FDFA01831A176D" modified="2018-12-05" version="1">MSLTICNVHFTQQPERIVWLSSPLAKQLKLNGRKSVNVKLGRDTVPATVRTINRAGNHVYMSAGLRRSVRIPMSGNVHLSSADTDEIKLGPLIGILTDSATKSPTSPFGTRTGFVKQLLYMGRKKAYFFAFTPRDINWQQETVHGWFLDSGGTWFRRVVPLPDVVYNRLPSRRAETGTTISALRERFIRKQIPYFNWSFFNKSDVYKLLDNDPEALNHLPESVNNPTPERIREMLEKHHFLYYKPTAGSLGIGIYRLTYHPRRGYFVRYRRGSGNVLLRFTQFSSLMKMLRSRHGSGLSSYVVQQGIRLIEIDNCPIDFRFHMHKNGSNEWVVAGIGAKKAGRGSVTTHVKNGGSLMTPEQALNRTFGSKADEVLREAKRVAVKLSEAIERNHKHTLGELGLDIGIDRDGEVWMFEANAKPGRSIFKHPALKEQGKASLEYILDHCLYLSKFRKKEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXN1</accession>
    <name>A0A398CXN1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03744">
        <property type="protein sequence ID" value="RIE03744"/>
        <property type="gene ID" value="D3H35_09305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="163" mass="18847" checksum="182511202E9D44BA" modified="2018-12-05" version="1">MSQRLSTTLPAQPPHFPLLLLFNNLFCLAFGAGLTKQTCREGISSFKAVYRRKAGRPRKSVELKEPPNIMIDTNSYNVLKLEIRLEEVLMKIMNYKFVFYSTVFIFVALFFFLNNDWEHRVALLLLATVLFGIIRFAPRKLVGISVIIVFIVFRIIDMLLISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXW3</accession>
    <name>A0A398CXW3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05378">
        <property type="protein sequence ID" value="RIE05378"/>
        <property type="gene ID" value="D3H35_00910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="324" mass="36724" checksum="01F966BD0791B67B" modified="2018-12-05" version="1">MNTEKNDLSRKKNDATQAIVKIKENYVLWEKSVVDQLNMSSTHPMTTGGYREEVWQSIFDRIVPRKFSVARSVFIIDSNGRVSNEVDLAIFDEQYTPYIFRNGLIKYIPIEAVAAAVQCKSTETSGADSWAQSITALHTSFTGISRMATGIACGDIPYKDETGNWIQYPPVDADAKRKRLALTQTATRPILILCHMAADKVRDHVKQEFDIMMAPSGERLKIEIVSRSKEESSLTDSIAYWLTELNHKVNSVNPIQIPHAEYDPKLEKMSLNQLKVREREGGNEISLLTLTFQLNQLLMLVNNPLLFPHQAYADLFNHIPIPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXW5</accession>
    <name>A0A398CXW5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_03860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04637">
        <property type="protein sequence ID" value="RIE04637"/>
        <property type="gene ID" value="D3H35_03860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="84" mass="9947" checksum="F57C039B4DC322FD" modified="2018-12-05" version="1">MNNGFVVFRRRRSRFYLEYQISISFRSSYIYLIPTQSYFDVQGTPKPFLLVQSCFAQRLHMIMEDIGRKPILFAFRLNILAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXX2</accession>
    <name>A0A398CXX2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03844">
        <property type="protein sequence ID" value="RIE03844"/>
        <property type="gene ID" value="D3H35_09845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="60" mass="6527" checksum="1848D642F253784E" modified="2018-12-05" version="1">MDAEEEDVQPVSADAKHEGKDAYDMDIDRMINEGLGGGQVTIHNGLITESSTDYMEADNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY00</accession>
    <name>A0A398CY00_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04101">
        <property type="protein sequence ID" value="RIE04101"/>
        <property type="gene ID" value="D3H35_09160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="386" mass="43800" checksum="41D54D9B2A42C656" modified="2018-12-05" version="1">MIICTVTAANHLAFAKVLAKSAKAHVKGCKFVLCLMENEIHPEATGFDDVVLIKELGIPDFKRHIASKNIYELSGIIKPYLLQHAFDRYANETKFVYMDADSRIYGSFSKLDELLNRHNILFTPHRAKPQNHPDAAAEELVNLKNGVFQVGFIALSKTAESRRFLAWWSARCRDHAVVDYNRGLFGDQKWLNLAPCFFKGVYILRDPAYHVASWNLSQRKLKRDSKGGLTVGGNPLVFFHFSGMGRWLDKSIELHASKNGNVQNLVNQYKQDLKDSGYDQLIAIPWGYEKILRHEANQPAAQLTFHPMVVHEPIINGFIQEPNEEEDADEGEPIIEQGSESLTLVPAESAATSLLGKPSWKKRFLAPLWEKIKEFKTTLIQKLFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYY3</accession>
    <name>A0A398CYY3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">glmS</name>
        <name evidence="11" type="ORF">D3H35_02695</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05057">
        <property type="protein sequence ID" value="RIE05057"/>
        <property type="gene ID" value="D3H35_02695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="287"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="459"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE05057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="611" mass="66489" checksum="B0F3A950A0B2A3AA" modified="2018-12-05" version="1">MCGIVGYIGNRESQPILLEGLSKLEYRGYDSAGIAVFTENGLEVTKTVGRLANLEGRLTGDPLRGTVGIGHTRWATHGKPSDANSHPHTDNSLKFSVVHNGIIENYLELKEELMLAGHRFLSETDTEVISHLISVEYEGDIVKAVQKAVRKMRGAFALGVLTEHEPDRLVAVRYASPLIIGVGEGEKFIASDIPAILEHTRDIYILNDGEMAVLTRDGVELMTVEGNPIAKEIFRVDWDLMTAEKGGFDHFMLKEIHEQPKAYRDTMRGRISEDGKNVVLPELTTLTPETLKGINRVHIVACGTAMHAGLVGKTVIETLVRIPVETDVASEYRYRSPIITPETLVIVVSQSGETADTLAALREAQRCGAKVLAITNVVGSSVAREADDVIITLAGPEIAVASTKAYTSQLIAFYLFGLYWAQTTGSQTAEQIAHILAAMDSLPEQVERILSQADTIKTVAEDISKSSSLFFIGRGLDFAVALEGSLKLKEISYIHSEAYAAGELKHGTLALIEEGVPVIALLTQEDLYEKTLSNIKETKARGAHVLAIVNEGHEAEVAKSVDRQFAIPRTLQLLSPALSVVPLQLLSYYASLALGHDVDKPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ51</accession>
    <name>A0A398CZ51_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_03105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05127">
        <property type="protein sequence ID" value="RIE05127"/>
        <property type="gene ID" value="D3H35_03105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="151" mass="18067" checksum="A1652E6D8EFB5275" modified="2018-12-05" version="1">MICFKYSRPYFLIEDSILPFRTELYFEIFNCFLDEDEILLFAGPVKTTDREYLKYIEERKVLTGSIDTWSWWPKSRKEIIWFRPNTKLEILKEIRVFCSCFVTETKNKNIINFSYALTLEETDEGICLYISEKQSGSFLSEVFQRLKSLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZD5</accession>
    <name>A0A398CZD5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04581">
        <property type="protein sequence ID" value="RIE04581"/>
        <property type="gene ID" value="D3H35_05720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="93" mass="11169" checksum="24513BC8956B6CE5" modified="2018-12-05" version="1" fragment="single">MHQDQLEYPVAQLIRDRRTVRQFREDPVPQLLITKLLDIACWAPNHGFREPWRFIQYRGEARRTFAESVVATFSAEEKEKNGDRRLAYYMDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZJ9</accession>
    <name>A0A398CZJ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05287">
        <property type="protein sequence ID" value="RIE05287"/>
        <property type="gene ID" value="D3H35_01850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="114" mass="12584" checksum="85D8E14E17E1B82D" modified="2018-12-05" version="1">MLFDKQTGDAPSPAGPKISFALSFSHNAKPALYGDNQSAFSVQLTKEGVIALREALQGEMSPIGIIYSLDYLALRPAYSVRLSIDWERVQNHLDETFGSDSIFINPKLRKPSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZW0</accession>
    <name>A0A398CZW0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-antigen ligase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_00780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05397">
        <property type="protein sequence ID" value="RIE05397"/>
        <property type="gene ID" value="D3H35_00780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="403" mass="44922" checksum="76C470021796A292" modified="2018-12-05" version="1">MFPMFAASLLLFFTGFRFRPGDTLLLIFAAYSIGHSLLASVGYGETGSSVKHAITLLFGLSMYRVSVYIAEQSKLDPALRRQIVLSLLIGLVPPLAVGLLQMLDAYVLHSGLSGTLTALFSEKVYRGRIQMLSGEPSWAGIHLLSGGLLLLYLYKEGYRKLTLVPLIGTALLLVLSFSAYAYSVLLTALLIYVLIANRHRGRMFLALAGIVLVVAVGVPFLLETLSVSGYFTDRFQFDFGHLIRADNSFFIRVVFPAIGMMEFAHHPIFGVGGGFYYREFADLLVRHFEYGLKFTEVSNLVNDHPEMATSRNLWSKLFAEEGLVGAFLFLGFMVAAFRSSRGSVYAQFAYALCVALVMNFDSYSFVNFWLLIGWIRGGFFEDRPAVRAAEWDTQNGRELRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0G1</accession>
    <name>A0A398D0G1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chorismate mutase AroH</fullName>
            <ecNumber evidence="1">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">aroH</name>
        <name evidence="4" type="ORF">D3H35_03960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04654">
        <property type="protein sequence ID" value="RIE04654"/>
        <property type="gene ID" value="D3H35_03960"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02185">
        <property type="entry name" value="AroH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008243">
        <property type="entry name" value="Chorismate_mutase_AroH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21164">
        <property type="entry name" value="PTHR21164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07736">
        <property type="entry name" value="CM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005965">
        <property type="entry name" value="Chor_mut_AroH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01796">
        <property type="entry name" value="CM_mono_aroH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51167">
        <property type="entry name" value="CHORISMATE_MUT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2 3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>prephenate</name>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>prephenate</name>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>prephenate</name>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005965-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="122" mass="13441" checksum="0D0A28CA552A8E13" modified="2018-12-05" version="1">MSVRGIRGAITVDANEEKLILDGTIELLNEIVRVNEIVPEDIASVLVTVTQDLDATFPARAIRQMADWELVPLMCSIEIPVKGSMERCIRLMVLVNTDASQADIRHVYLAGAAALRPDLSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0Q6</accession>
    <name>A0A398D0Q6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_02825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05081">
        <property type="protein sequence ID" value="RIE05081"/>
        <property type="gene ID" value="D3H35_02825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="159" mass="17868" checksum="5E38003F4BB88430" modified="2018-12-05" version="1">MFLTTTLTTAMNNATFPVTVISSAYQPASGQRNLAIANGMMIRRRAGIRRWPSSSPVSDTYRLQRRMAAEAKFLSVYTQVNEEVWTERERSALGVTEEKFGAVLLMNEMLPDPILESALVHELSKFWAGFETPDEATVRLTDKLRQALELDPVLTEDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D182</accession>
    <name>A0A398D182_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YheC/YheD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_03370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000019">
        <property type="protein sequence ID" value="RIE04934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04934">
        <property type="protein sequence ID" value="RIE04934"/>
        <property type="gene ID" value="D3H35_03370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026838">
        <property type="entry name" value="YheC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38437">
        <property type="entry name" value="PTHR38437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="181" mass="20273" checksum="0E61CA6B6B83EB1E" modified="2018-12-05" version="1" fragment="single">MSLTICNVHFTQQPERIVWLSSPLAKQLKLNGRKSVNVKLGRDTVPATVRTINRAGNHVYMSAGLRRSVRIPMSGNVHLSSADTDEIKLGPLIGILTDSATKSPTSPFGTRTGFVKQLLYMGRKKAYFFAFTPRDINWQQETVHGWFLDSGGTWFRRVVPLPDVVYNRLPSRRAETGTTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CAY0</accession>
    <name>A0A398CAY0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000060">
        <property type="protein sequence ID" value="RIE00296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00296">
        <property type="protein sequence ID" value="RIE00296"/>
        <property type="gene ID" value="D3H35_29320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="12"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="292" mass="34283" checksum="0CA6884E1715B061" modified="2018-12-05" version="1">MIRMNSTKSKIKDIYPLTPMQQGMYFHSLKDKDSGTYFDQVCFDIEGNLDTALLEQSINKLIERHDILRTIFSNKSKQVLQIVWKERPLKVFFENLNGLGIDQQNTIIINYKQKSKVQGFDLGKDQLMRFALFQREKEKYTMVWCFHHILMDGWSRPIVTEELFAIYRSLSQQESLSMLPTIPYSRYIQWLESRDQQRALQYWKDYMQGYENVVSVPMKENKANCPFLLEETELVLNTEWTGIVTELTKQLQVTVNTWLQTIWGVLLQKYNGVDDAVFGSVVSGPSFRDCGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CB24</accession>
    <name>A0A398CB24_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_28380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00346">
        <property type="protein sequence ID" value="RIE00346"/>
        <property type="gene ID" value="D3H35_28380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="339" mass="37765" checksum="5A04A38A5BD34B5E" modified="2018-12-05" version="1">MKITIQDIANAANVAKSTVSKVINDSPKISGETKRKIREIMKEMNFTPSSIATRLAKQSSFNIGLLFDMSQDKDYLDPFFYNIMVGIESVIGPLKYEMTMANVHHNDPDRHFLKRLVLSRRIDGLIGNNANLTNEAAAKLEELRFPFVLMGEYDAFPVSWVDFDNAEGGRMLTGHLLEQGYRDIAFIGGEREERLFENRHRGYSDSLRAAGLPISAERTFHGIADDSHGYESVLSMLRSAPGERPDAIVCMSNQVAFGALRAAKEAGVQIPNELGIATFDDFPFSPHTSPPLTSLLIDTFKLGSAAADMLIERISYPELPRRNLLLQPELIVRESTARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBU1</accession>
    <name>A0A398CBU1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FecR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_27045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00626">
        <property type="protein sequence ID" value="RIE00626"/>
        <property type="gene ID" value="D3H35_27045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017385294" description="FecR domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="3">
        <location>
            <begin position="67"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1104" mass="120837" checksum="E60DB0791B09CF0D" modified="2018-12-05" version="1">MSKKSSLTFMAFLLVAIPFLGVFARDTYAATSRVGIIKELTGTVEVKKSGGTKQFKAYKKMSLNEGDVLTVGPKSSAVLQFSNGSSEDDRVTAGAGSTLTFSKLTDRGGTTTKISLLSGTTWSEIKSIKSKDDAFTIETPTAIMGVRGTHLFATVDPLSGSTLTMVASGFANVAKKTNGSARPNGGNPTTTIYPTQQIIVDVQGSSQEMDDSVTFLDVDEIINHASPEVIEQFIRNKAQIDKENEELIKKKKADLESLLNRTPGLNVGSPEELDKLMKNVSNLIGALAKDAIDKGKLTAADIERLAKEAGTSIDLRNTELELSKLEQDKLNKEKEKLAELQKKKQEEAKKEKEKLNEQVQAALEAQRRAQEAANKAAESEIKKKALEEYERQLSELEKKRLEQDRQTNGEVVPSPTTGTGSGTGNGGSSAFYGIKYNIIGSGTANEWVKALPFGALQSDYSLEVPFGAIYAVVSPRLNATTTVSTVRYSEDGGESEMSYYATFDETMGGYIVPLIFEHTYIAISGIKADNSSVFVGVALTKRDQPEGLASSSQQYNELSGSGITWNPFEWEYGYGGIFGARVPSESTDLKWTLQLTGGAVKAVVKQITYSGSETEVLSPVTMMSNVETLFTISSKYDYFLVELFDANNHQVGHPIIYWLIDDDIVFGEDDHPFDLKDSSGNAVDYRLGNSESRGFQARVDASVNELRFYSAEGTDLTLEKAIVFEESDYNSDEYYPNNAGVITVPLTNESTSLMVEMKDIGGGSHYYDLIVHRYDLPQGVADWHLIDDLDEEMIWEQARNLPSGSPKRFVASVSGDSSWTDLHFDPTSGSELKLYDSYGELVKTFTAEEPEYRVEFNGNGYYRFKLMNGTKATEFVIERGFVSSQLDENEFLINQAGNERVTIPTYNYEGDDFEKGFAVVTDDIANPIMFALDSDFGDIELRTDNSAVHISEPDGDGYRTLNFSEPGTYDVSVEVHSPLDYSDATKYLLTVYYGSVPAAIDLTPSQIAYAGGTVNSVTYLGSYTYQINMTQGLTQNPFVDLTLSFSGTIKGFSSDDGMTASQAGAAYILYGVQAGASKSIYLTVENGTGHRITYVLIFQVGFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CC87</accession>
    <name>A0A398CC87_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Asp/Glu/hydantoin racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_28590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00380">
        <property type="protein sequence ID" value="RIE00380"/>
        <property type="gene ID" value="D3H35_28590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036361">
        <property type="term" value="F:racemase activity, acting on amino acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="229" mass="24188" checksum="D25193C370A5AECB" modified="2018-12-05" version="1">MRTVVAIYTGQGLADPLKAVFKEVLPEVRLVNIIDDSLIGDVVRAGHIPAGVARRLVQYYHNGEELGADVILNTCSSVGELADGAGAYIGVPIVKIDQAMAAKAAAEYGRIGVLATLPSTLEPTVRLIAKEAGLLGKEVSLVKGLAEGAFDALVGGSPEEHDRILLETARRVCEEADVLVLAQGSMARMEKTLREATGKPVLSSPRLGVEQVKEVLARLDREQAGTNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCE2</accession>
    <name>A0A398CCE2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_28665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00390">
        <property type="protein sequence ID" value="RIE00390"/>
        <property type="gene ID" value="D3H35_28665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="113"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="221" mass="25596" checksum="713243EF4959C5D3" modified="2018-12-05" version="1">MDEIAEPGSFILYDESFPQSYRSYNSVFTNDWFHFKPDKDDQAFLNGLEIPRNRPVPIGDLHELSLMVNQLSYETYASNRFKSETIGLLLKLFFIKLSNKIHDCSLDIANGNYNKMSIIRSKIYNQPFKPWTIAEMSHELTMSRSNLQHLYKRFFGVSPIDDVIASRMEHAKYLLSTTNIAVKKIAEMCGYNNEIHFMRQFKKATAVTPSEYRANKGGQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCH1</accession>
    <name>A0A398CCH1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ger(X)C family spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_28835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKC lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00420">
        <property type="protein sequence ID" value="RIE00420"/>
        <property type="gene ID" value="D3H35_28835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008844">
        <property type="entry name" value="Spore_GerAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038501">
        <property type="entry name" value="Spore_GerAC_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35789">
        <property type="entry name" value="PTHR35789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05504">
        <property type="entry name" value="Spore_GerAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02887">
        <property type="entry name" value="spore_ger_x_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="391" mass="43914" checksum="B226B7F94FCB2217" modified="2018-12-05" version="1">MRAYGFATLSVLVLFLLTGCWSRVELDELAFVQGVAIDLTEDGSEIDLTVQFYKPTSGGKDSSGNSGNSGERFINLKTKGASIFEAVRDVAIHLGRKASWTHMRILVIGEKLAQERDIGEILDFFARDHEPRLSMSVMIGKDRADAYLKTKPFIEASTSQQLREVGRFSYKYAGKTMRISLRDLMLDLKSQTEVSSVPYIYFDRENGASITTVTGLQILRKGKWVSDIPTERIESLLMLIGKYKGGVLQAPCADHKAPEIRKMESVEVESIKTVTEVKITNDRAKARISIKARGYAGELICSSIKSPEEAAKFNQKIKKSLEQDLDLTLQFLQERKLDALGIGNRIFRQDPALWARWKPEWEERFSKLPITVEVEVNVFNTGANIGQHLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCW2</accession>
    <name>A0A398CCW2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00550">
        <property type="protein sequence ID" value="RIE00550"/>
        <property type="gene ID" value="D3H35_27815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="86" mass="9312" checksum="FD922AB19556BD0D" modified="2018-12-05" version="1">MSRIAPNGARVLSRQVLGEVVRPIIAGKLAAEGFPLWGRGAGVLFPVIESGAGYNCYLLYRSTSDSVKLPGIGHKIRDLFLIRFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDB7</accession>
    <name>A0A398CDB7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Formylglycine-generating enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00690">
        <property type="protein sequence ID" value="RIE00690"/>
        <property type="gene ID" value="D3H35_27320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="214" mass="24394" checksum="F181F74D33E3B880" modified="2018-12-05" version="1">MVKIPAGEIELRDDRIKTTWTVQVNSFLLASVPVTQALYFSILQKTVGPNDRPQAPVADVSWNDAIRFCNLLSQHSGLKEYYSVSDDGESVVCNWEADGYRLPTEAEWQHACKAGTTGYRYGELNEIAWYHENSEGRVHEAGQKLPNAWGLYDMLGNVWEWCWDVYDVKVYGSYRVFRGGSWAEEARGCGATCRRRSHPTFRIDDLGFRVARSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDM0</accession>
    <name>A0A398CDM0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bax inhibitor-1/YccA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00730">
        <property type="protein sequence ID" value="RIE00730"/>
        <property type="gene ID" value="D3H35_26405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010539">
        <property type="entry name" value="UCP009160"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41282">
        <property type="entry name" value="PTHR41282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12811">
        <property type="entry name" value="BaxI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009160">
        <property type="entry name" value="UCP009160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="246" mass="26958" checksum="5F589E0AA19060B8" modified="2018-12-05" version="1">MIGRTGNPTLNEKTFERTRGLSGQDRMTLEGTVNKTFITLAVLLGAAFCAWAMYFDGRNVMPIAVGGAIGGLVLSLIISFRPTTSPYLVPIYAALEGLFIGALSARYEVQFEGITLQASLLTIGVFIALLLAYKSRLIRATENFKLGVFAATAGIAIVYLLSFVLSFFGVSIPYLHDSSWLGIGISLFIVVIAALNLVLDFDFIEQGSQQGAPKYMEWYGAFGLMVTLVWLYIEILRLLSKLRSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDY8</accession>
    <name>A0A398CDY8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00923">
        <property type="protein sequence ID" value="RIE00923"/>
        <property type="gene ID" value="D3H35_25480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="290" mass="31000" checksum="A3956AE71A2016EF" modified="2018-12-05" version="1">MRIGAIEAGGTKFVCGIGTERGEIEDRVSFPTERPETTIANVIAYFKDKSVDAIGIGTFGPINVNPGSPQYGSITTTPKPGWADFPFLETLKREFDVPYGWDTDVNAAALGEATWGAARGLDNCVYYTIGTGIGVGVYAEGKLVHGLVHPEGGHVLTRRHSQDAFEGICPYHRDCLEGMAAGPAIEKRWGAKGSELSSEHPAWDIEAFYIGQAVTGTILLLSPQKVILGGGVMQQKQLFPRIRSEVLKNLNGYVNTSDILEHIDTYIVPPGLGDNAGLLGSVALGVRALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEF0</accession>
    <name>A0A398CEF0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_26965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00825">
        <property type="protein sequence ID" value="RIE00825"/>
        <property type="gene ID" value="D3H35_26965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="147" mass="17076" checksum="874C4553A9A8122C" modified="2018-12-05" version="1">MLGREQIGIGENFFEIGGHSLRASAMASAVSKELNVDVRIGDIFRTSTIKALSNLIQNKEISSYKLITPADEREYYPQSSAQKLLFIQNQMNPQDKTYNMPKGYFINGELDRNRFELAFKSLISRHESLRTSFHWMTENRYREFIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFT8</accession>
    <name>A0A398CFT8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01583">
        <property type="protein sequence ID" value="RIE01583"/>
        <property type="gene ID" value="D3H35_24875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_12" evidence="1">
        <location>
            <begin position="44"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="203" mass="22876" checksum="09B441A6722875CF" modified="2018-12-05" version="1">MGNTDKFEMIANTYDTPERIHIAKVSSDAIRNYLVDAKSKNAIDFGCGTGLVGMNLLNDFNSMLFLDTSPNMINQIQQKISDSNIQNVDTLCFDFEKEGLSDLHADYIFMAQVLLHIEDVEFVLSRLFDVLNEGGHLLIVDFDKNEKVASDIVHNGFNQDELAGIMTKIGYRDIQSHTFYNGSKLFMGQDASMFILDSQVRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFV1</accession>
    <name>A0A398CFV1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aliphatic sulfonate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_23720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01380">
        <property type="protein sequence ID" value="RIE01380"/>
        <property type="gene ID" value="D3H35_23720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010067">
        <property type="entry name" value="ABC_SsuA_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01728">
        <property type="entry name" value="SsuA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017314585" evidence="2">
        <location>
            <begin position="35"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="3">
        <location>
            <begin position="55"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="341" mass="37333" checksum="9F2F290C9E2DC0B0" modified="2018-12-05" version="1">MKPGLFRVRKTVVTALVAAALLAAVMTACGKNEAASGGTDEPIKIALSPWPGWFFWYLVEEKGFFDKHDVDVKLEWFPVYSDSLQALSTGKVDANSQTLSDTLAPASKGIKLRAVLVNDNSDGGDAIVSKQEFNSIKDLKGKTVATELGTVDHLLLLTALEKNGMSENDINYTNMTVNDAGPAFITGKTDASVLWEPFQTTAVKEGKGKILFSSKETPGLIPDLLVFKESVVKNRPEDVQKIVDAWFDALNYFKEHEQESIELLAKHAETSPEDFKLGLESIKLFTAQDNVAAFEKKDDYTSLSYTGNKTAEFLKKLDMISDIPDIDALLEPKFVQKAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFZ1</accession>
    <name>A0A398CFZ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD-dependent malic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_23575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01355">
        <property type="protein sequence ID" value="RIE01355"/>
        <property type="gene ID" value="D3H35_23575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="6">
        <location>
            <begin position="95"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="5">
        <location>
            <begin position="240"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="475" mass="51470" checksum="415A6B62B3B1AC9C" modified="2018-12-05" version="1">MNDWSRNFSGKNIIIRLEMNSARITFGEVATAISSAGGDIVAIDIIGTTSTATVRDLTVNAGDTGDIAKITDALAKLSDVRVMHVSDRTFLLHLGGKIAITPKTPIQNRDDLSRVYTPDVARVCMAIYEDPSKAFTLTIKRNTVAVVSDGSAVLGLGNIGPRAAMPVMEGKAMLFKQFAEVDAFPICLETQDTEEIIRAVKQIATAFGGINLEDISSPRCFEIERRLREELDIPVFHDDQHGTAVVLYAGLINALKLAGKSIDEVKVVVCGIGAAGIACSNILLAAGVKELIGVDVEGILTADSHYDNPMKRWFAERTNPNRLRGGLADALEGADVFIGVSKGGVLTREHVQRMAQRPIVFAMANPTPEIHPEEIEDLVAVVATGRSDFPNQINNVLCFPGIFRGALDCRAIDINEEMKLAAAEAIASIISEKELNRHYIIPSVFNQNVVKTVRDRVVQAAIDSGTARRIPRDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG90</accession>
    <name>A0A398CG90_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_13135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01743">
        <property type="protein sequence ID" value="RIE01743"/>
        <property type="gene ID" value="D3H35_13135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="77"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="285" mass="31685" checksum="9A48DA04277A6EA4" modified="2018-12-05" version="1">MRSKGLNFTFSGSLKSLMLFIAFGLIVIVNIVPILWGLKTSIMSPSDIFSYPPKLFNFEASFEHYIRIFNGGYFQTFLNSIFYCVASIIFGLFLGLLAAYGFDRFSFRLKKPMFYLVVFCIPLSIGSSALIIPNYLYMSELGFLNEWYTLPILYTAYNLPMAIWIIKSGVETIPVEVDEAATIDGASRSYIIFGMMSVLCRPALAAAALFIFLGAWNEFILSSIMINSPNLRPVQLAIYQYLGFFGQEWGPLTAAASAAIIPSIIVFTFLGRMLISGLTAGSVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGI0</accession>
    <name>A0A398CGI0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01565">
        <property type="protein sequence ID" value="RIE01565"/>
        <property type="gene ID" value="D3H35_24775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="282" mass="31816" checksum="15DD5DB0317E8D21" modified="2018-12-05" version="1">MNKGQRENIAAITGASAGIGLALTRKLLSENWQVVALNRSDFPPDDRRIQEAIQRGWLRIYKTDNLADYAALRRALEEVKSKEQRIDILFNNAGGSFSELSYSKQGREYHYELMTVVPYIILMELKELIKSGRLKTVINTSSSALKFTKEFTIESLERPKSFRKLLGPYATSKLALSLWTQAIAPQLAKDDIKIRSVDPGGNNTLRKGKNSGLPLLVALLMKLFFSPPTHGANRLYEGALGQHQNETGVFLLKDQVAELKSKDQARNVLERINSIYEHEFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGN2</accession>
    <name>A0A398CGN2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01112">
        <property type="protein sequence ID" value="RIE01112"/>
        <property type="gene ID" value="D3H35_22100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="180" mass="19928" checksum="9300285697907C18" modified="2018-12-05" version="1">MTKKTNWWGISSIVGGTVWIVSWIVIALRPEAESGGYREVDDVHIWIMTGMAFILVGCLGMHWFGRRSKSLAEHLLGVPLLAGASLMAIGRWMQHQGWDPQPTVAIGWILLFLGLFSYGVNEIVKRTAPLSIGAAYLITACSLIVMNDQDWRAWLAVPFGAAWLLLGTVALRTSRSDNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGY5</accession>
    <name>A0A398CGY5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_30110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000064">
        <property type="protein sequence ID" value="RIE00168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00168">
        <property type="protein sequence ID" value="RIE00168"/>
        <property type="gene ID" value="D3H35_30110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="46" mass="5507" checksum="19E6CE31D10794DD" modified="2018-12-05" version="1">MRILVAEDNKINQKFIEFILKKLGYEIDMVHNGIEVLKLMRRTLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGZ6</accession>
    <name>A0A398CGZ6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01232">
        <property type="protein sequence ID" value="RIE01232"/>
        <property type="gene ID" value="D3H35_22835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="84" mass="9478" checksum="36F58C418DDE8580" modified="2018-12-05" version="1">MIRRTLVQMTVWNSTIVFCLFVMLGGALYGLARYQIYSDIDRHLTSDIDHMKQVILGTGSKSLPLNRKNRSVISWVIGGIPTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHF8</accession>
    <name>A0A398CHF8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02193">
        <property type="protein sequence ID" value="RIE02193"/>
        <property type="gene ID" value="D3H35_15745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="102" mass="11034" checksum="462994D16B005DB5" modified="2018-12-05" version="1">MKANIQRALRKWLIGAGCTLSVALLFQYARTSDTYQASVNTETSGYTQNDTPAANNDTGSSLGRNGWRERAGQREDSGSSLDDRSDSSSGDSFGFRSQTRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHH5</accession>
    <name>A0A398CHH5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannose-1-phosphate guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00549">
        <property type="protein sequence ID" value="RIE00549"/>
        <property type="gene ID" value="D3H35_27810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="342" mass="38014" checksum="EBE37B33D604B452" modified="2018-12-05" version="1">MKIVLLSGGAGKRLWPLSSEMLPKQFLKVIKSKYNHSISMIQRTHDILSGKFGTDNVFVAAGLHHHSILAEQLGEDANLILEPSQRDTFAAIAVACSYLSSIGVNPDETIAVLPVDAYVDPDFYDKLEDLDRLIGQDRANLGLIGIRPTYPSEKFGYIIPFAPAGDPSSFDVSRFHEKPETETAAELIEQGALWNGGVFTFRLRYMEETLKRLNQPWDYTELTGSYHQIPRISFDYMVVEPETRIACIRYEGVWTDLGSWTEMIHLLDHDNDSNVIKDGNCDGTYVINQLHLPIIVAGIPNAVIAAGPDGILISDKDYSHLIKPLVDQVESLKSSIGRAENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHM6</accession>
    <name>A0A398CHM6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3533 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_24420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01502">
        <property type="protein sequence ID" value="RIE01502"/>
        <property type="gene ID" value="D3H35_24420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="2">
        <location>
            <begin position="34"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="399" mass="41686" checksum="3CE5386E0F91996A" modified="2018-12-05" version="1">MALAKQKVLWIGVVGVFVALMIFGAAMMGSVLGAKPKDLPVALVVLDQSAALPDGSALNVGEMVKGKLLGNTQLPIEWKLVGSEEEAREGLDNQKYYGALVLPADLSSGVLSLSTPQPAPATVKILVNEGMNTQAATAVKQVLGQASRALGSELSNQLLGQIGQRTEQLPISTAKALMTPFTTQEEIVHPNGTNNASGNAPGLLTQVMWIGSLVVSIVLFLALQKAVAGGARRGQAVLGQTAIGLVLIAAASGFVVWMASSWYGMQMADAAHVWLVLWLGGSAFFLLQSALLGWIGMPAMGLLVLLMFFSMPVLNMAPEFLPQATQDWLYSWTPLRFVASAIRNAMYFDGVSVGGSNIAVLWSVAGAFLVVLLASAARKTKSVGGAAAEAEGNKVAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI05</accession>
    <name>A0A398CI05_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flagellar hook-associated protein 2</fullName>
            <shortName evidence="5">HAP2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Flagellar cap protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_15005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FliD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02070">
        <property type="protein sequence ID" value="RIE02070"/>
        <property type="gene ID" value="D3H35_15005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009421">
        <property type="term" value="C:bacterial-type flagellum filament cap"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010810">
        <property type="entry name" value="Flagellin_hook_IN_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040026">
        <property type="entry name" value="FliD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010809">
        <property type="entry name" value="FliD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003481">
        <property type="entry name" value="FliD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30288">
        <property type="entry name" value="PTHR30288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07196">
        <property type="entry name" value="Flagellin_IN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07195">
        <property type="entry name" value="FliD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02465">
        <property type="entry name" value="FliD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="FliD_N" evidence="6">
        <location>
            <begin position="11"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="FliD_C" evidence="7">
        <location>
            <begin position="222"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="511" mass="55127" checksum="F9EC0DA60A5C6C23" modified="2018-12-05" version="1">MTIRVNGLGSSGLDIDTLVSQMVQAKRVPIDQMKQKMTYLGWQRDAYRDMNTEMTNFMKEAQKLTLQSSFMTKKAAMSAADADKVKVSPTSGAFTGNMTLKVTQLAKAASLTSSAATGLASNPAQALGVDTTLTIAGAAGSKDISILSGDSVTQVVSKINAQSSSTGVKAVYDKLSDRFSLVSSQTGEASTVQIIDQGNTNMLFTKLKIAADGANDTTAIQGQDAIVDFNGTGDVHVGSNTFTMNNINFTLLTDPGVTPYTISASNNIDVESVISTIKGVFEKYNALIEKTNGKLSETKYRDFSPLTDSQKEVMKEADITMWNQKAQSGLLRNDSILSSGLNKMRLDLSNNVSGLTAGQYKSLADIGITTAPPNGNLLAYTEQGKIYIDEDKLRNALTNAPEQVMELFTKDGTRDANNKLKNGGADAGIGVRLYESLKSEVISGLTQKTQIVPSRSYLNLQLDDYAKRISVAESSMSDYEQKLYSQFSKMQSSLEKLNKQGSYLSNMFQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI99</accession>
    <name>A0A398CI99_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01762">
        <property type="protein sequence ID" value="RIE01762"/>
        <property type="gene ID" value="D3H35_13240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017327063" evidence="1">
        <location>
            <begin position="24"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="258" mass="28524" checksum="6DFC3DCA316D3DB8" modified="2018-12-05" version="1">MKKMFLVLALILVVAALPVTAFASKGLTETQLESTKVATKHFSGASNLINDSYIKDVFNEVKRFELLNPNSSQDQRNEYTVSVLRKYAALPEKSSQFTTYSYSSWLPPSVKGDLNASELALFDSDPTRGLKALVAGQEALDYTLYKFGSQGHNNRADAFRHVTWNVWMTAWCGTTFAANWSSAHENNSGNPQLEKDMDTWNNNYGRAYAVIAGLTENSSVNTTRATINTAYFSGNLKTFNSTGTALVQFTGVQSDYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIP1</accession>
    <name>A0A398CIP1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative sulfate exporter family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_14305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0324 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01942">
        <property type="protein sequence ID" value="RIE01942"/>
        <property type="gene ID" value="D3H35_14305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018383">
        <property type="entry name" value="UPF0324_pro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30106">
        <property type="entry name" value="PTHR30106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03601">
        <property type="entry name" value="Cons_hypoth698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="349" mass="36708" checksum="D4DCC4D1751A7381" modified="2018-12-05" version="1">MIAKPQTPITANPFSAFPVPPLAGGILLTFLLALLGWTLSLLPGLDRLGALACTLFLATLYRHLFHYPEALRPGIRLSSGTLLRAAIVLFGLKLNVSELLGLGLPLLARSAGTIAFALAAVLLLGRLFKADRALTLLLAIGTGICGAAAIAAVSPIIRSKDEDTAIGAGLIALLGTAFAALYTLLQPWLPMDPSVYGIWSGLTLHEVAHVAMAASAGGPDALAEGLLAKLCRVFLLLPVCLMLAAWMKRKHKDKTGEEAGTIQRFPFPWFLLGFVAMSLVGSYLLPNVLDNPAPTLHGVSLLTTLLLAMAMAGLGLNVSLRDLRSRALRPLAAMAVASAALSTIVWFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIQ9</accession>
    <name>A0A398CIQ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_14420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01962">
        <property type="protein sequence ID" value="RIE01962"/>
        <property type="gene ID" value="D3H35_14420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027132">
        <property type="entry name" value="SMC6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="PTHR19306:SF6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="76"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="316" mass="35307" checksum="C577A4E805BA6D03" modified="2018-12-05" version="1">MFRYPRKLPPIKRFHDFYSIFQSILRFIDEAEAICYDKCNSRKHRSNLFLTGRGGRNVDEKLDLILEIVIGLRSDVETLKADMVEVKGDIAELKADVAELKADVAELKTDVATLKADMAEVKADVAELKADVAELKADVAELKADVAELKADVAELKVDVAELKADVAELQTDVATLKADMVGVKANLSALNADVSVLKTEMAGVKFEISGIKVEISGIKSEMDDMKTTIARLDVRMERMSLTLEKTFETADNRRRASLICTKDMDDTSFCSTRLPKACWSKAPDTDLPIRSNSFPFNAKTRLIRPIRARMRRVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIU8</accession>
    <name>A0A398CIU8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fructose-1,6-bisphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glpX</name>
        <name evidence="6" type="ORF">D3H35_26730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the FBPase class 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00788">
        <property type="protein sequence ID" value="RIE00788"/>
        <property type="gene ID" value="D3H35_26730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01516">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004464">
        <property type="entry name" value="FBPase_class-2/SBPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30447">
        <property type="entry name" value="PTHR30447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03320">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004532">
        <property type="entry name" value="GlpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00330">
        <property type="entry name" value="glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="186"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR004532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="321" mass="34353" checksum="49D34C9ACCAEC978" modified="2018-12-05" version="1">MERELALEIVRVTELAALASAPWMGRGNKHHADGAATSAMRAMFDSISVKGTVVIGEGEMDEAPMLYIGERVGSLNGPEVDVAVDPLEGTEIVAKGLNNAMSVIAVADKGNLLHAPDMYMEKLAVGPQLVGKVSITDPIEVTLRKAAEALQKPVRELTVMILDRARHDSLIKTLRKVGVRIKFLSDGDVAGAMAPAFPEAGIDLYVGSGGAPEGVLAAAALKCLGGELQGRLMPSDGKEYDRCIQMGIEDPYKVLTMEDMIGDGDVIFAATGVTPGEFLGGVRYLPDQRAETHSIVMRAKTRTIRFIRSLHYLPSKTLLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJH6</accession>
    <name>A0A398CJH6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">M6 family metalloprotease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_12540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03476">
        <property type="protein sequence ID" value="RIE03476"/>
        <property type="gene ID" value="D3H35_12540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005085">
        <property type="entry name" value="CBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM_fam20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03423">
        <property type="entry name" value="CBM_25"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05547">
        <property type="entry name" value="Peptidase_M6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01066">
        <property type="entry name" value="CBM_25"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017439739" evidence="1">
        <location>
            <begin position="45"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="555"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="738"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="920"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="3">
        <location>
            <begin position="1099"/>
            <end position="1205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1206" mass="128038" checksum="0386293B8BB1D47A" modified="2018-12-05" version="1">MIVQTVAYQMTKGADVPMKNVYRVLYLFSFLLLTALCAGGIASAAPARTDLQTFTQPSGVTFQARLQGDEHLNWAVTAVGDILIRDNQKYWNYAEIGANAPKASGSKFGIDAKPSSAIDQADLQQLNELHPEVFEGPAQSGIFAESSELHNSGSPALSAMSTTGNQKILVLLVQFSNVSMQYSDADWSTTFFGTTGKTVRNYYRDVSNGLLTFLPATESSGTSNDGVVKVTLNYAHANKETSNNSKTIVKDALTAADSYIDYASYDTNGDGYIANDELQIVTILAGKEESYGDTGSNPSVWGHQGFLYGSLIPTLDGKQLCSYSVGAGYTQQGEMHGTHKATIGILAHELGHMLGLPDLYDTDGSSSGIGSFSLMASGSWGALSGEYSGVTPTQLDAWSKVRLGFVQPTVVKPNTSTAYTMKSLLTGGYNVLKLPTAVPEQYFLVENRQLEGYDASLSAVSGGIAIWQIDDSRGSNSDDNRRWVDLVYGQPWDPLYRTGGGTQFGPSTAPNSDRFRAADGYSKKYTGIRVNVNSASSQNMTVNVYGDYDNTAPAAPTGLVSSYQTASTASLTWSPSTESDFDHYLIYQNGYYLDSQEINQFKFGMLSENTSYSVSVKAVDLSGNESGASTFTVSTTSGPDQIIVYYKRGLSNPILHYNSFFKDSVWYSTAMSQSEIPGYSKATITVGNIPNAIQAKITDGSGTWDDNNGNNYIFSPGINVLDNGVVYTELPDTQAPTAPTNLASTGKTDTTVSLSWTASTDNVGVTGYDVYQGTTKVGTTASTSYTVTGLSASTAYTFTVKAKDAAANVSTASGAITVTTNAPTGNVVTIYYKQGYTTPYIHYKLNGTWTSLPGVAIPAAEVAGYNKITINIGTATQLEACFNNGSGTWDSNNGANYFFPAGTSTYNAGTIVSGAPDTEPPTAPTNLSSNSKSDTTVILTWTASTDNVGVTGYEIYRGSALIGTSTTTNYSATGLTANTAYTFTVKAKDAKNNVSSASNAITVTTDSSAGNTATIYYKRGFAAPYIHYQPEPGVWTTTPGVLMTQSEFAGYSKITIPLSAATGVRVAFNDGNGNWDNNGGTSYYFNTGVSTFVNGTITSGLPQVDSLTIVVTAPSNTPSNADLYLASSLNGWSTNDSAYKLTKNTNGTYSITLSIASGTSFDFKVTKGSWAGVEANSNGTDIANRTFTTSGGAQTLNITVQRWKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJV7</accession>
    <name>A0A398CJV7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Baseplate_J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02590">
        <property type="protein sequence ID" value="RIE02590"/>
        <property type="gene ID" value="D3H35_18070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006949">
        <property type="entry name" value="Baseplate_J-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04865">
        <property type="entry name" value="Baseplate_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Baseplate_J" evidence="1">
        <location>
            <begin position="740"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="993" mass="109401" checksum="C2FFA0FE5AB7E82B" modified="2018-12-05" version="1">MAVFSRRPGCRTALFFLAAEMLGENAKRLNRVPLNNLVSFLDLLQVSLQPARPAKAHVVFSLNEGVREPVFVPGGTVIAAAAEDGGEDIPFETESALLVTPAKLTDLLNVNPARDRIVLSAEQYDEALAANAAPEIPLFSVEGVNLQEHVFYLRHDDLFRLDHPARLILKWHNAEKRYVETELAAVAGRSDWMEWSYSQGDEWIPFEDMSVSGREVTLRKKSSGPVEETVIGGISGRWIRCRIRPAADGVSAPEALGAVPDMDRITLRASHDRQLDAAGIPADELYFNDTQLDGAGFAPFGEHFLPYAVFYAACPEALSKRGSRLTMTFKGRVVPSSLRSAPDPEIKWKMVMRTFDFEKKPLPRILIRKVQWEYWNGDNWMKLQGTARYDELFAQMPEEETDYRLEFDCPEDLAPAYVNGREDRWIRARVLAVDPISAPVVEYMSPWLSAPAFSYAYDDSDELIAQSAFTLNNAELRDVTATARQGGATFKPFVPIACPSPALYAGFDSPPLKGPIRLQFTLGRKVPAEGEAPWIEWEACVRSAAGGWKWVALKTSDDTEGFTENGTLQFVGPAELAPVSLFGRERVWLRALNRDGKYGEAGAAVPTAASIRRNSVAVVQRQTITGEYPERGRGGFVLSRSPVISEEIWVDETGHVAEHELERQLEAAPERYEVYRDSDGGIQRLWVRWERVRSFGASTSDDRHYTLDSASGLLQFGNGTRGMKPPQDGGDKIRATYRVTEGLRGNTAAGTITNLLQPIAFVERAVNPAPAVGGGDTEPLDGALRRGPQQLKHRGRAISASDAEWLVREIDPGIVKVRCLPNRDARMQRKPGSLAVAVLPAGGREASEHFPAVKRKLEAELRERASNLVATGGRLTVMLPVLLEVSVTATVAVDSPDFVMPAESMCLERLSRFLDPVTGKSDGQGWEIGEPVHPSVFYGLLQSVRGVQRVEQVHLNVFKLENGVTTEIPAGSLGDLPHGIVTSGTHRVNVVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK03</accession>
    <name>A0A398CK03_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copper amine oxidase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_24510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01519">
        <property type="protein sequence ID" value="RIE01519"/>
        <property type="gene ID" value="D3H35_24510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017369144" evidence="1">
        <location>
            <begin position="24"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="2">
        <location>
            <begin position="45"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="2">
        <location>
            <begin position="110"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="431" mass="46946" checksum="31E061425873FB75" modified="2018-12-05" version="1">MRKLLAPLMAVILLLTFAVPTLAAQPIKLTVNGKAVTGVNVKTQKGTLYIPFKDTSKLFGVTSTFHKESNSVIVGKGIEQAKKMKRTSAARLIVNGKVITGVTNPTISSSTHIPLLKVAQALGVKASWNDKTKTVTITTASLTTKSIPEIENLQNALKSFSADLNLNSESVSALTKYQKEFFAKDRSPLSLKKVAKTVSAKDIAKKVSSYYSAIVRLSPVELDSVQEFKLSNGQVVTGAIGHTGGTYSQITESWKDSTYFVIFYLGSNDLKKGDKATVNGIPVGKTQIELTNALGATWQEPLYAVAAGNFLSVSEEYDIEKEQSQGGSIDWSALDKKTQERINKLLLVTLSDEGLLINDRTYTYGLEITKVQINDYEYVPTSKTELPDGSLTIPISSFKDSKGNPLTAQSGSFFVMITTNKGEFFKYVDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK75</accession>
    <name>A0A398CK75_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4386 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01599">
        <property type="protein sequence ID" value="RIE01599"/>
        <property type="gene ID" value="D3H35_24965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025495">
        <property type="entry name" value="DUF4386"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14329">
        <property type="entry name" value="DUF4386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="233" mass="25749" checksum="4A8E97BB645E597C" modified="2018-12-05" version="1">MTQHRRNGIIIGIFYFAAAVTSIIAVILYEPILSEQWVMSVANGFKTKVLLGVINDLLLILTAVGTAVMLFPYVRRWNEQLALGYLCFRFMEAVLIAIGVVSILGLLQLSIQFEANGLANQENVRELGYTLQAFHRWTSMLGPNFMLGVNTTMYSYLLFRTGLVPRPLALFGIITAVLVFAAGLLEMFGIVEPLSAAKGLIALPVGVYELSLAVFLIGKGFRKPNLEKLMQVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKD0</accession>
    <name>A0A398CKD0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_19470</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. EmrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02815">
        <property type="protein sequence ID" value="RIE02815"/>
        <property type="gene ID" value="D3H35_19470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="10">
        <location>
            <begin position="11"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE02815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="523" mass="56314" checksum="1BC3EFD5684F897A" modified="2018-12-05" version="1">MDAQKSNSRMVVAGLLLGLFMAALDQTIVSTAMATIIKKLGGMESFVWVYSAYMIAMVVSTPILGKLSDMYGRKRFFLLGLFLFVVGSILCGTAQNMDQLIIYRAIQGIGGGALMPIVFTIIFDLFPIEKRGKMMGLFGAVFGISSVFGPIMGGAITDNMSWRWIFYINVPIGILAFLFILRAYHESKITRKPSIDWAGAVLLTGAILSLMFGLELGGSDGWAWGSVKTISLFVASGVLLVLFLLAERAAKDPIIRLSLFKKRLFTSSMMISLLYGGIMIAGATYIPIFIQGVFHKTATQTSTVLIPMMLGVVLSSQVGGRVAGKFKYRDVMIVSGLILLVGSLLLGFEMDTSTSRFLIGVYMVIIGLGMGVSFSLLNISTLNSVEPQYKGSASSLITFFRTIGSALGITIFGTLQKHEFQAGIKELPNLDPRLLAEIKGGQALLDPVVQAKMGLSAEAVGALLSKLADSIISIFQWSIILPVIALIFAILMGRARLETAKPAQKGSSEPHGDGASRPEPSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKE0</accession>
    <name>A0A398CKE0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1450 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02770">
        <property type="protein sequence ID" value="RIE02770"/>
        <property type="gene ID" value="D3H35_19215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009910">
        <property type="entry name" value="DUF1450"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07293">
        <property type="entry name" value="DUF1450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="89" mass="9977" checksum="AA30B0FAF66BDA37" modified="2018-12-05" version="1">MMNIVEFCVGNMHHGTDRVMHRLENDPDVEVIEYGCLGNCGECYLSPYALVNGESVVAETADKLYDAIREAIGQQEEERTALDKLLDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKE6</accession>
    <name>A0A398CKE6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03183">
        <property type="protein sequence ID" value="RIE03183"/>
        <property type="gene ID" value="D3H35_18195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="31"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="408" mass="45159" checksum="F32E5C3E724EA1F1" modified="2018-12-05" version="1">MYLHTGSLYWPATLPGHRSYPALRERIRTKAVIVGGGMSGAVCGYVLAKSGIPAVLIEQRTVASGSTSSNTGLLQYSNDKMLSEFACEIGEEAAVRFYRACKQAAEHIADIAESLPGKSEFKRRSSLYFASNAQDVPALRKEYDLLVRHGFDADWWDVERISSRFPFRKEGAIVTRGDAEINPFRFVHGMAEAAADSGLRIFENTAMLSTEGKKGAYRIRTDNGEIEAEHIVYAVGYTPETAGGQWIRANLGRSYAIVTSPLPSLAEWHERFMLWETARPYLYARTTADNRLIVGGLDENVRTPVLQAQDVRTRAMRLLAEIKKLFPGLKPKIDYSWCAAFGESADGLPWLGEDPDRPGQHYCLGYGGNGTIYSMLGAQIIRDRILGENNPVADIVKPNRLVAASRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKF2</accession>
    <name>A0A398CKF2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RraA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_28510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00367">
        <property type="protein sequence ID" value="RIE00367"/>
        <property type="gene ID" value="D3H35_28510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="SSF89562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="218" mass="24091" checksum="777D3ACF40030D0A" modified="2018-12-05" version="1">MNDQQWFDRLCETLYTAVISDTLDELGYRNQVMSEKINPIDPNWVVAGRAKTILSVDVHYLPEDPYAKEIEAVDSVKPGEVVIGCTNESKQNGLWGELLSTASKVRGARGAIVDGLIRDTKKILELGFPVFATGTKPVDSQGRGLVIDYDIPVKCGGVLVRPGDIIFGDRDGIVVIPSELAEEVFSLALNKATRENHTRDELLEGRTLRQVYDKYGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKI7</accession>
    <name>A0A398CKI7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_19835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02875">
        <property type="protein sequence ID" value="RIE02875"/>
        <property type="gene ID" value="D3H35_19835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010766">
        <property type="entry name" value="DRTGG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07085">
        <property type="entry name" value="DRTGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="204"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="265"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="447" mass="48946" checksum="042AC98171F9382B" modified="2018-12-05" version="1">MSGNGGASGELTKHERLMGYIRELRIGTKISVRQMAKEQGVSEGTAYRALKEAEDLGLVSTKERIGTVRVDKKRRGNPEQLTFAEVLEIVQGNLLGGEEGLDKTLHKLVIGAMELDEMMGYIDAGSLLIVGNRESAHRLALEHGAGVLITGGFDASEDVKTLADERQLPILTCRHDTFTVASMINRAMYDRIIKRKIMMIADLIEPSARIGSLKPSASVTDFLKLSAETGASRFPVTDEWNRVVGMVTTKDVMGSTPDQTLDKLMTRRPMTVTLSTPVASAAHRIVSEGIELLPVVDRQRKLIGVIGRGELLRAMQFANRPAQLGETFDALMWSGFAERRDGEGRLLFTGAATPQMSGPLGTISEGVLTALMQQAAARAVADLRKREHVVENMTTYFLRTVPIDASITIQPTIIESNRFYVKMEVQVMQDGDVMAKAMLTAQMIDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKP1</accession>
    <name>A0A398CKP1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Allophanate hydrolase</fullName>
            <ecNumber evidence="2">3.5.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">atzF</name>
        <name evidence="2" type="ORF">D3H35_24110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.54" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01448">
        <property type="protein sequence ID" value="RIE01448"/>
        <property type="gene ID" value="D3H35_24110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004039">
        <property type="term" value="F:allophanate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014085">
        <property type="entry name" value="Allophanate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02713">
        <property type="entry name" value="allophanate_hyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="584" mass="62996" checksum="4D1DB441E033ED11" modified="2018-12-05" version="1">MLRRKQQENKLSIEQLRQAYANGETMPEEVVRNIIQRAEEDAGMNIWITPPRMERIRPYLDRLSALDSSAMPLWGIPFAIKDNIDWAGVPTTAACPDYQYVPNEHATVVARLLAAGAVPVGKTNLDQFATGLVGVRSPYGETHNALNPELISGGSSSGSAVAVARGHAAFSLGTDTAGSGRVPAALNGIVGFKPSLGAWPTTGVVPACASLDCVTVFATCLEDAFDVDKVVRGFDEADPWSRSVPSPSPALPSRLLLPKETLRFYGPYAKEYERAWQTTVERLGELGIPIQYVETNLFEQAADLLYGGPFVEERWAGLGAFIEAHPGSVLPVTKHVLRPEEKSPYDGVSVFKAIHSLQAIKRETGKLLKDAVLIMPTSGGTWTREQVRNDPVRTNTEMGRYTNHCNLLDLSGVAVPSMEAAGNVPFGITMFALARNEGYAIGAAERFGGSPPGRLQTPSPNHTLVAVCGLHMRGLPLEKQMLECKARFLREDKTASKYALYKLSTVPSKPGLVKQEQGGSSIDLEVWEMPLESFGAFAASIPAPLGIGRVELQDGTEVPGFVCEAYAAADAVDVTSLGGWRALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKU4</accession>
    <name>A0A398CKU4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_28095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000053">
        <property type="protein sequence ID" value="RIE00507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00507">
        <property type="protein sequence ID" value="RIE00507"/>
        <property type="gene ID" value="D3H35_28095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="104" mass="11710" checksum="F6C59386E1B8079C" modified="2018-12-05" version="1">MVLDCFDMRRRMNRVPCNMRWLGKLLFGNCGDCAILWLPAQICVARPFAPCRSSSSLRILRSFAGSGLFSLPASQARTLLLGFPFENFGLRRRSEPRNCPGLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKW4</accession>
    <name>A0A398CKW4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe-S cluster assembly protein SufD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sufD</name>
        <name evidence="3" type="ORF">D3H35_08325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03956">
        <property type="protein sequence ID" value="RIE03956"/>
        <property type="gene ID" value="D3H35_08325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01981">
        <property type="entry name" value="sufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="103"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="435" mass="47299" checksum="6CBE49F869335AC2" modified="2018-12-05" version="1">MSTPTTSFGREAAAALARSKNEPSWLVAWREEAGELAQTLELPKPEKTPIHRWTLDQYGTYRPGASAAAKAELPASIAALLPTDANGPLIVQHNSSVTFIHLPEELKAKGVVLSSLEEAARTHEKLVQDHLMTAYGKDEHKLSALHAALWNGGVFLYIPKNVEIEEPIQALIFADDAEATFMPHILVVADTNSRVSFVEQAATALESGNTTTLLLNGAVEIFSKAGAHVRYASVHHMDESVIDVSYRRAILDNDARVEWIIGELHNGNILTDTKSILKGNGSNSDAKIISVGTGSQRMSLTTQAVHFGRGSESDMITRAVMKEEATAIINGITKIEHGATKANGQQTERVLMLSPKARGDANPILLIDEDDVKAGHAASVGQVNADQVYYLMSRGISRKEAERLIIHGFLDPVVSEIPLEGLREQLHRILERKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL15</accession>
    <name>A0A398CL15_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_28035</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00587">
        <property type="protein sequence ID" value="RIE00587"/>
        <property type="gene ID" value="D3H35_28035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="78" mass="8315" checksum="A2704E0DE710CC39" modified="2018-12-05" version="1">MAKFTYVDKDTCIACGACGATAPDIYDYDDEGLAEVIFGSDGNHGNTEIPEDLYDDLQDASDGCPTDSIQIADAPFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLN2</accession>
    <name>A0A398CLN2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Insulinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03345">
        <property type="protein sequence ID" value="RIE03345"/>
        <property type="gene ID" value="D3H35_11710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16_C" evidence="1">
        <location>
            <begin position="184"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="428" mass="48060" checksum="716517E3EA5EB03C" modified="2018-12-05" version="1">MTEHFERGELGRLRIHVLPTKRFKTFACALYAGIPLTESGVTPTALTPFVLRRGTRSYPETIAFRERLDDLYGAGFGFDIYKRGDHQIVQFKLDMINDRFVSSNESLLKEALVFLGDVVTEPATEGDSFRARYVEAEKTTVTKRIDAIINDKIRYAAERCVEEMCKDEPYRLLSLGRKDDLAAITPDSLYASYKHWLKNASFDLYVSGDTKLAEVKEIAAKAFKLPEGEPAIFSRTSVVPARAEPQTIVERLDVGQGKLNMGLRVGSTYADPNYAALLVYNGLLGAFPHSKLFVNVREKASLAYYASSRIDGHKGIMTIQSGIEVQNFDRAVTIIKEQLAAMERGEFAAEDLARTKAMLANQLREIQDSAFERIGFDYNAVLSGIERTSDSFRGEIEAVTPDQIREAAKGVKLDTIYFLRDRKEEGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLP1</accession>
    <name>A0A398CLP1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spore gernimation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_26560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00757">
        <property type="protein sequence ID" value="RIE00757"/>
        <property type="gene ID" value="D3H35_26560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024255">
        <property type="entry name" value="GerPB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10803">
        <property type="entry name" value="GerPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="71" mass="7464" checksum="DD72BC2D03C7A352" modified="2018-12-05" version="1">MIWNVYQTITIGQLKVNGVTNSSVLQIGSAGNIQSLSQLYNTGGFTGPAPQIGEVAETSQELSFVPLPNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLP5</accession>
    <name>A0A398CLP5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Regulatory protein RecX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">recX</name>
        <name evidence="7" type="ORF">D3H35_11765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Modulates RecA activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the RecX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03355">
        <property type="protein sequence ID" value="RIE03355"/>
        <property type="gene ID" value="D3H35_11765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01114">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003783">
        <property type="entry name" value="Regulatory_RecX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33602">
        <property type="entry name" value="PTHR33602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02631">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="266" mass="30360" checksum="AED33D3F5250D30C" modified="2018-12-05" version="1">MLQPMREIEVIGAEVLSLEAHPKRPGMYRIALRLEKPAQSDEAEYGTDAEVTTGSSAAELETFVTVHEDTLIGWRLLKGRRLTGEEWTELKREEEKEEAYRSALGFLERKARSSKELALALKRKGFEPTVIDGCIERLHSRRMLDDTAFAKRFAEQRAVSQRKGRRLIRQELIQRGIGKADADEAVGELSGEVERQSAIELAHKRWPLTKGDYRNRKHKLIAFLLRRGYPMGVVRQAVDEAALRDEESGRDDDEVDADDMGIESWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLR6</accession>
    <name>A0A398CLR6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.14</ecNumber>
            <ecNumber evidence="2">4.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">eda</name>
        <name evidence="2" type="ORF">D3H35_26725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.14" evidence="2"/>
    <dbReference type="EC" id="4.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00787">
        <property type="protein sequence ID" value="RIE00787"/>
        <property type="gene ID" value="D3H35_26725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008700">
        <property type="term" value="F:4-hydroxy-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="215" mass="22394" checksum="FDBFE67BA3A67D5A" modified="2018-12-05" version="1">MPSLLLQQLIEHQMVAIARGIGADRIEPVANALADGGIRLLEVTLNTDGALEMISLLRANTGDRLHIGAGTVLDLGQAKEAIAAGAQYLISPHLDESIVAYGVEQGVDVWPGAMTPTEIVRAYQAGASAVKLFPFASLGIGYLKEIRAPLDQIPIIATGGVNPQNIRSVLDAGAVAVGLGNGLLDRGMIRSGDYEALTKHARSFVAAAKATNGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLU3</accession>
    <name>A0A398CLU3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_26920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00817">
        <property type="protein sequence ID" value="RIE00817"/>
        <property type="gene ID" value="D3H35_26920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006326">
        <property type="entry name" value="UDPGT_MGT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01426">
        <property type="entry name" value="MGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="409" mass="45396" checksum="9E7A0B36201B126B" modified="2018-12-05" version="1">MSKILFINGPSAGHINPTFPLVEQLIEAGEEVVYFSSEEFRWKIEGMGASFRAYGNFLKSDDPLETKQFMGLILKLLSSYSIVIPGVMEQIKGETFDYVIHDSMYGCGTTISNILKLPHISTCTSFINAERMSSTQQRQDQPSGPTVSIVENVSHMKAFARLSYEVSQKFGIKRPNIDEVFFNKGQLNLVFTSSDLQPGSHSLDDSYEFVGFSPSRRAGELEFPFERLTDQSVIYISLGTMYNNDKDFYEICFAAFASFRGKVVLSLGNRVEAGAFPCIPGNFIVRNHVPQLEILKHACMFITHGGMGSTNEALSLGVPLIIVPMAADQPIVARRIQDLGAGILLNRDDLTPDLLRTTAEQVMLNPSYSKRSAELGESLITAAANNSALRAILRFKEKMNVELSLRKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM10</accession>
    <name>A0A398CM10_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_27365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00681">
        <property type="protein sequence ID" value="RIE00681"/>
        <property type="gene ID" value="D3H35_27365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032979">
        <property type="entry name" value="ENGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005201">
        <property type="entry name" value="Glyco_hydro_85"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013378">
        <property type="entry name" value="Listeria/Bacterioides_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042229">
        <property type="entry name" value="Listeria/Bacterioides_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246">
        <property type="entry name" value="PTHR13246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09479">
        <property type="entry name" value="Flg_new"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03644">
        <property type="entry name" value="Glyco_hydro_85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="SSF48726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02543">
        <property type="entry name" value="List_Bact_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017479246" evidence="5">
        <location>
            <begin position="32"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="6">
        <location>
            <begin position="1074"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1409"/>
            <end position="1491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1720" mass="185414" checksum="4987DCFF2DC8A51E" modified="2018-12-05" version="1">MKMKKKAMSKITAALLSATLVATGMPLHVYAGDTWPFQGESAHGTNQPSVHGYTSGHILDWSPETDRDAEMLRSFVPLQKRIAPLAATQAKPALNPNVKMTNVSGDYGNAFIENAAYTNKFAQYHFGFWQYVDYWSPWHGTATAYTPPEYYDDLAQSDWKQKWFEFGMLNLPNPTYTDAAHKNGVLSLAGVFFSNNDRGQQTYKQMIVKDANGEFPVAKKMIEMAEYFGYDGYFINQEEQSPNVQTSDIPDYIEFIKTLKKGGLYVQWYDSLNTSSGANTFARTFNNNNISLLYDKNKNEAVSDSYFFDYGVGSTQINSANTYLNQLNSTYGTNYSIYDVGFAGLEAGRDRFTSTNVTALKNKLDANGVPLLSIATLGADFVHAGYNDDKPWPSNDRANNDYQWETKKREQQWWSSPNANPRETAASNVWPGISSVITERSVIGSSNFYTNFNTGQGLSYYKAGAVSNDDEWSNMSLQDVPVTWQWWQDTTGSRLTVDYDYGSKYKKDSSFNYEQIGGYDGGSSLAVSGNLDAENFLRLYKTELNVKAASKLSISYNKPSAADASSLSIGLIFTDDTNTVVKVAAADGSNTAGWTTKELNLGAYAGKTIAAFGLVFAPNGGVIANYQMNVGQIRIYDGAAALPGAPTGLALTHAFTDTNEMVIHWNMNTDYSKVKNYNVYVNNVFVGGKYDKTFYIKKLPAESGVVKVVPVGADGREGAAASLPFDLNAAVSDIQVDSKADGELAVSWTNPATASDPITVSVKSLNWITTDAPVSVTKTVPAGSTSAVFADMPVNGDDYVVSIAVGNKQPVAKSGNFIDKTIEPYAEAWSWNGNTLSLPMPNTRDWRYLYVYENGTAMQFDTTYSSGKKPYIVRGRSVKGSLFVTPTSSSSIVTLVMEDYAGNKSEPLFVRDPALNSSMFPDTALLNGLIEQGYTVASDLTKITGTLDLSNRDIKDLTGLKLIANMTGVNLSNTKLETITASSFPSKVAGVDLSNNKALLQITSEAFSGITDLQQLNITGSDKLQLLDVSNSTLKNLVYGDKTAFPELIALNLSGTPIDMTAGQPARIFADQIKKQVDPDKSVSVIRYENAARQSTLTGASFDQLSNLTDGITTTGTAYSLTSTLPGHVIMDFGKAVDMKTFNMYAYSSIYRAVDFTIESSLDGTTYTPIGGSPYVGNALTPFSETFASPVKGRYFKLTVTKGNTTPTVLMELEMWANVPYPFPSSVKYDGYNGLHTITFDTDGGSNPPAQITDAAYGSKISEPVGVEKSGYLLDGWYAGDQKWNFATDTVTDNLTLKAHWSKDPDKSIWFATDLDATKTVNEGDDVSLQAAAAGAVDSMVWEVKAAGEDAWNRTTVTSAVYSFTAQEQDNGKMFRVVLTGKDGVVPATLTSSELTLTVAPVGVVVEQPTIGRFDVTKNPAIIGDAVSFTVEATGSGSLSYQWYKDNALIEGAAGASLSLANVTAGDAGRYKVTVTNTVTAHGKAYTASATSEEIALAAVKGNAAEWTQLQTLLTDIDALAGNAKYTASSIASLKSSVAYKEAKKLTIAAEAELLSQAYTDLAKAKSDILVVYVPVVTPPVDSGTGSGTVTPPTDPTKTVVSASELTKPAENGKIVVTVDPAAKDIELPISADDLLGANTLQLRSDKWTIDIAPEALKKWKDSLDGGLLTGSKIQNAVNPQTLSESGANPGAYVSLRAAPLRSISASLPAKANLTRFPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM87</accession>
    <name>A0A398CM87_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02339">
        <property type="protein sequence ID" value="RIE02339"/>
        <property type="gene ID" value="D3H35_16615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="148" mass="16804" checksum="594B7D6B1E49B83F" modified="2018-12-05" version="1">MKELTGLGWTTRAANVRMEELTGYGWATRAANVRMEELTGYGWATRAVNVRMKELTGYGWATRAVDLRMEELTGYGWATRAVNVRMKELTGYGWATRAVDLRMEEITSLSWATGSADVRMEEIFGCSRGKCGEVKVHAKNRRIARRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMA6</accession>
    <name>A0A398CMA6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Molybdenum transport system permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">modB</name>
        <name evidence="10" type="ORF">D3H35_12000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03392">
        <property type="protein sequence ID" value="RIE03392"/>
        <property type="gene ID" value="D3H35_12000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011867">
        <property type="entry name" value="ModB_ABC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02141">
        <property type="entry name" value="modB_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="12"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="222" mass="24510" checksum="0BEDA70017747694" modified="2018-12-05" version="1">MAIDWNDFFAPVWLSLKVSLIGSILVFVLAAATARWMAKRRFMGKSLLETVLLLPLVLPPTVIGFLLLMLLGRRSWIGEAYEWFVDSPIVFSWIAAVIAAVVIAFPLAYRTMKAGFEDVDPELEKAARVLGANEWQVFRYVTAPLASRSLVAGFILGFARALGEFGATLMIAGNIPHRTQTIPTAIYVAIDGGKQDLAWAWCIAMVLLSFVMLLLANGYSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMB5</accession>
    <name>A0A398CMB5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 4">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">galU</name>
        <name evidence="6" type="ORF">D3H35_09575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 4"/>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03793">
        <property type="protein sequence ID" value="RIE03793"/>
        <property type="gene ID" value="D3H35_09575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01099">
        <property type="entry name" value="galU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="5">
        <location>
            <begin position="6"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="296" mass="33231" checksum="C0CA9BC8085FD8FB" modified="2018-12-05" version="1">MKKVRKAIIPAAGLGTRFLPATKAMPKEMLPIIDKPTIQYIVEEAVESGIEDILIVTGKGKRAIEDHFDHAFELESNLVEKGKLKLLEEVQRSSKVDIHYIRQKEPKGLGHAIWCARRFIGDEPFAVLLGDDIVRSEVPCLKQMIQQYDHVGASIIGVQPVSDIETQRYGIIDPSGKEGQLYRVNNFVEKPPLGMAPSNLAIMGRYVLTADIFPFLETQETGVGGEIQLTDAIQKLNEIQQVYAYHFYGTRYDVGEKLGFIQTTIDFAMSNEELRAPLLESMERIVRAEYVARVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMF5</accession>
    <name>A0A398CMF5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sigF</name>
        <name evidence="8" type="ORF">D3H35_05425</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04536">
        <property type="protein sequence ID" value="RIE04536"/>
        <property type="gene ID" value="D3H35_05425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014236">
        <property type="entry name" value="RNA_pol_sigma-F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02885">
        <property type="entry name" value="spore_sigF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="252" mass="28612" checksum="69E9191B91B49806" modified="2018-12-05" version="1">MDLEWKRTSPPAFLDDSEVKRLIALSQSGDTTARDSLVNSNIRLVWSVVGRFANRGYDSDDLFQIGCIGLLKSVDKFDLSYDVKFSTYAVPMIIGEIQRFLRDDGTLKVSRSLKEMANRVRKVKDELSKRLGRLPTIGEVAEELGVTPEEIVFAQEANKPPASIHETVFENDGDPITLMDQIADDSQERWFDKLALTEAIQGLSERERLIVYLRYFRDQTQSEVAGRLGISQVQVSRLEKKILQNIKDQIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMP4</accession>
    <name>A0A398CMP4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000031">
        <property type="protein sequence ID" value="RIE03735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03735">
        <property type="protein sequence ID" value="RIE03735"/>
        <property type="gene ID" value="D3H35_10010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="89" mass="10211" checksum="AE59E57B10186898" modified="2018-12-05" version="1">MPPRLKPPSKAPTRRWPEDLDINLYLIRSSYNDSSLAIEYRRLGDISNTRISLVYDKKLVNESVRKELDRRLSAADLKLVQAAGELGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMR4</accession>
    <name>A0A398CMR4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000043">
        <property type="protein sequence ID" value="RIE00881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00881">
        <property type="protein sequence ID" value="RIE00881"/>
        <property type="gene ID" value="D3H35_25840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="78" mass="8715" checksum="A289807FA5C2DE80" modified="2018-12-05" version="1">MSGSIPISVVSNFKISISLPSGYELNPFGWNQSVEIWSKDGERENQYPAFIDIDGNLGILSFDSFQPNTEYEINLLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMY3</accession>
    <name>A0A398CMY3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">General stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02609">
        <property type="protein sequence ID" value="RIE02609"/>
        <property type="gene ID" value="D3H35_18170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025889">
        <property type="entry name" value="GSP17M-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11181">
        <property type="entry name" value="YflT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YflT" evidence="1">
        <location>
            <begin position="6"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="107" mass="12135" checksum="2354B734637C3545" modified="2018-12-05" version="1">MRAYAKLVNNGLEAVDVVKDLHRQGFTREEVYVLAHGKERTDRLADTIDTNKVGLSEEGMFDSIANLFRSRGDELRSKIESMGFEPREAHLYEAALDQGKVLVMARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN95</accession>
    <name>A0A398CN95_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Cysteine desulfurase</fullName>
            <ecNumber evidence="4 6">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_08320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4 6"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03955">
        <property type="protein sequence ID" value="RIE03955"/>
        <property type="gene ID" value="D3H35_08320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="7">
        <location>
            <begin position="23"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="408" mass="44638" checksum="36479F09D02776C4" modified="2018-12-05" version="1">MDPNLLKAEFPILGQEINGYPLVYLDNAATTQKPSSVINAIKRYYEWDNANVHRGVHTLGSRATDAYEGAREKVARFLNAANSRQIIFTRGTTAALNMVASGYARQTLREGDEIVITPMEHHSNLIPWQQAAKATGATLKYIPLQPDGTIALADVESTITENTKIVAVTYVSNVLGTVNPIARIAEIAHRKGAVIVVDGAQSTPHLKVDVQALDVDFYAFSGHKMCAATGIGVLYGKAPLLERMEPVEFGGEMIDFVDLYESTWKELPWKFEGGTPIIAGAVSLGAAIDFLEQVGLHNIDAHEKKLTQYAIERLSAIEGLTIYGPREERAGLVTFNLGDVHPHDVATVLDTKGIAVRAGHHCCQPLMRWLNVSATARASFYLYNTEQDVDRLADALVETKEFFGYAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNE1</accession>
    <name>A0A398CNE1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_09390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03760">
        <property type="protein sequence ID" value="RIE03760"/>
        <property type="gene ID" value="D3H35_09390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="308" mass="34608" checksum="214F13A6292B659C" modified="2018-12-05" version="1">MKKITMKDIAKEAKVSTATVSYILNSVESQSISEDTKEKVMKAAQKLNYIRNLNARTLKSGKSELIGILLPQTAGESYWTPYRYTKAIFHLGKYLNRHGYHLIVVHIDPDSPKLDILLEREVDGVFVLNAAAKTFYQISKRYGLGIPLIGIDTYNEDTLFHKLIPDFTAAIAKVAELLGRRPDFVVIDDYRDKKYVDTIKAATGLDQRDIHAYADERRLRKFLAGRSGQAGCVINEFLCNQVLAEPFGGRVVAVCTSGVPELLPPSVPKVIFDPAAYEEAADILIRYIQQPHEPIDKKIIRLAVQDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNH6</accession>
    <name>A0A398CNH6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_24235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01467">
        <property type="protein sequence ID" value="RIE01467"/>
        <property type="gene ID" value="D3H35_24235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025984">
        <property type="entry name" value="DCTPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12643">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="100" mass="11482" checksum="B23A1442B38859CA" modified="2018-12-05" version="1">MDREMDVATRARLIEWLKTELVDQQSRLFKAMWDGSSARVTDSLSGLIASSYILGRRLGISYRELDAAIAGKLEKLRQEGHQLEDTYQDLSSLSEHIRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNJ1</accession>
    <name>A0A398CNJ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome C assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_07945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03892">
        <property type="protein sequence ID" value="RIE03892"/>
        <property type="gene ID" value="D3H35_07945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="6">
        <location>
            <begin position="68"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="273" mass="30570" checksum="D86A97065473B951" modified="2018-12-05" version="1">MITQDWLTDAILYIYALSLLFFVSDAASGNRTAKKMGTGLLVFVWVLQTAFLLMLLIRQFSEPALTIREYLFFVSWLLVSASFILNKWIRADLLVLLVNAVGFAVLALNLIQRPDNAITLSSHEAARRLLIVHVSLIVVAFAVLTVAAILSGMYLFLHGRLKRKQWSHVMSRMPGLELIDRYSYRAGLIGVPLLFLSLSTGTAALLAEGRYGNLLDEKLLLSYAAAALYIIYLLRRAALKDDGSRLAWWNLSGYALIIADFFSSSLSSFHSWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNP6</accession>
    <name>A0A398CNP6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02879">
        <property type="protein sequence ID" value="RIE02879"/>
        <property type="gene ID" value="D3H35_19860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="200" mass="22874" checksum="962521787305FE9B" modified="2018-12-05" version="1">MNVLTVVSHPRTNSFTFAVANRFVQGLKNAGHETEVLDLHRSGFDPVLWEADEPDWSADHKTYSPEVETEIERMKKHDALAFIFPIWWYSMPAMLKGYVDRVWNHGFAYGSSKLHHQRVLWLGLAGDSLEHFEKRQYDKMIAHHLNVGIASYVGIPNSKAEILYNTLGSKEGHSERLLTQAYDLGLHYAEFKGDASSEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNR9</accession>
    <name>A0A398CNR9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_22765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01221">
        <property type="protein sequence ID" value="RIE01221"/>
        <property type="gene ID" value="D3H35_22765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="349"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="422" mass="48868" checksum="45886F8CCD789257" modified="2018-12-05" version="1">MSLNNALLLLFTHGVPILFFAYMTTNVLLRNFKKVEHILLGLISVCYLLLFAEEYVRNQVSIEYSTLLSSLWLSSVGIIIPGLCFHFLIKFTRLDARLPRWIYPWIFYLPLIFVAVNLATGAQLISAQQFTESGMWKLPVYNEGYYIAMASSVFMDLLFLIPLLKGSSIAETQEQRSIYKQLIWGIAVSVLWHGVFGFINFGDHLPPYPYLYSGILWCYFLRRTMHKHDFLNLYDKRFEKLFNLNPDAILLVNLKGNVKNANPGAMRFFDSIRLEPARCFELLGLEIKTQIQAQVGIKQVETEVVTDSGRLVLLVNADYVWVDNEPHILLILRDITLQNQHQEDIRFLAYHDPLTRLPNRRYFYEKLEEALQEARNRQETLALLLIDLDKLKWLNDNGGISPEMTPCGKRRESCKNRSASEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNV3</accession>
    <name>A0A398CNV3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA mismatch repair protein MutS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_06000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04175">
        <property type="protein sequence ID" value="RIE04175"/>
        <property type="gene ID" value="D3H35_06000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005747">
        <property type="entry name" value="MutS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005814">
        <property type="entry name" value="MutS_YshD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MUTSd" evidence="6">
        <location>
            <begin position="9"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="7">
        <location>
            <begin position="321"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="508"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="143"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="663" mass="72672" checksum="D6B500A0ED001845" modified="2018-12-05" version="1">MREHSLKKLEYNRVIETLAGYAATYLGLRHARELKPSVDLGAIAKRLEETEEARGLLAKGAHAPLPSMEGMEQLISLLGTGYVLTEEDFGHLAQFAKSCSQLQQYMASKRSEAPSVALYAASMHSLAKLREEIERCVDRGRIVDTASAELHKIRKKIRAAEERIQKKLEGLLARYADLLQERLVSQRNGRYVLPVKKELRRRFPGTVLDESASGQTVFVEPAELAGSQYELSALRVEEAREETQVLARLTELAESYSYEISVNRDAVGHYDFLLAKAKWALAIGGESVKLNSNGVIRLKEARHPFLSVKPVPLTVEVGGEYRALLITGPNTGGKTVALKTVGILTLMAQSGLLVPAAAGSELAVFRSVEVDIGDDQSLDASLSTFSSHLRNVIDILDHTGPSTLVLLDELATGTDPGEGVGLAIAVLEELYRRGCVLMATTHFNEIKEYARATPGFRNARMAFDEDSLRPLYRLDMGEAGNSYAFVIAAKLGIPSAIVERAKSISKSLKGDAREAEEARKPGSAGSAGSADEGQTLSAQLEFSKAATSAGASTAASSSRNSGGDRSAVQPEWEVGDVVFIPHLRRSGVIYRLPDGRGNLIVQIQKEKIEINHKRVRRIIEKRDLYPEEYDMSIVFDTVENRKKRKLMGKRHIDGLTIEHPSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNX6</accession>
    <name>A0A398CNX6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00624">
        <property type="protein sequence ID" value="RIE00624"/>
        <property type="gene ID" value="D3H35_27020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="234" mass="25596" checksum="E7709EC7F277015E" modified="2018-12-05" version="1">MRAMVCTKYGSPEVLQLKEVEKPTPKDKEVSIRIYATTVTAGDCRIRGMNPPPMFKLPMRIVLGFRKPKKEILGIELAGEVEEVGKEVTRFRKGDLIFGSTGFGFGTYAEYICLSEDTALAIKPANMTYEEAAALPVGGVTALHFLRKANIRSGQKVLIYGASGSVGTYAVQLAKHFGAEVTGICSTANVELARSLGADKVIDYTKEDFSRNGETYDIIFDTVAKAHFQLAKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNY9</accession>
    <name>A0A398CNY9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02468">
        <property type="protein sequence ID" value="RIE02468"/>
        <property type="gene ID" value="D3H35_17365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="SSF50985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="325" mass="34696" checksum="8416A787FD8A80CA" modified="2018-12-05" version="1">MKLALKAQQLTLLQLKGELEAIMKSNVSLCLKMFIFFVTGSFILSFPAVHAQPYTAPAWGWKEIAVGSTHNLGIKNDGTVWQWGNTTTYSDKGAETNLAAFLPEKVPGLHNIKAVSGGQIHSIALGSDGTVWTWGGNHDGQLGDGSKISRAAPQQVSGLTDVVSIEADWGRSFAVKEDGTVWGWGGFYYRDSDGTVRNPDVPVRLKGFADIVSISTGYGNFMALKSDGTVWFGLGEVEQVSGLNDVVQIAVGAEFTYGLKKDGTVWYWGSDGMGMADGVSVADATPPRMLEGIKNVVSVQASAGGPFFSRMTVRYGQAVEIQAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP01</accession>
    <name>A0A398CP01_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">INTEIN_C_TER domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03930">
        <property type="protein sequence ID" value="RIE03930"/>
        <property type="gene ID" value="D3H35_08170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTEIN_C_TER" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="229" mass="25795" checksum="3127AB661D428EE7" modified="2018-12-05" version="1">MFTAGTKVQTDEGEKNIEDIEVGDMVLSKDEETREVAYKEVTATMNHETDEIYSIHVGDQVIESTFNHPFYVEDKGWTFVKDLKVGDLLVQSDGNTLEITSIELLHKHVTVYNMTVDEFHTYFVSDLGIWVHNTNCPFGKYEDAPYHGTTNNSVKIKAPIDGQDALNKSLSIGPNTDRRIAVSNGEFVVLDKTSDGLYHGHVRSWSELTPTMQAILRKEGLVDKKGRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPA0</accession>
    <name>A0A398CPA0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03139">
        <property type="protein sequence ID" value="RIE03139"/>
        <property type="gene ID" value="D3H35_15040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="4"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="317" mass="34985" checksum="4A83AEEBC723A57A" modified="2018-12-05" version="1">MNVLVTGGAGFIGRWVVDRLLKDGHQVWILDDLSNGEESNIEEFKSHPGLRQFVHGDIKDEAALSGLFEQGFDICYHLGASINVQDSIDDPTTTFNNDTLGTFFVLEQCRKHGVKMVFMSTCMVYDRCTDETGITESHPTKPASPYAGAKIGAENMVLSYYYAYGLPTVVIRPFNTYGPYQKTGGEGGVVAIFLKNKLAGKTLNIYGEGTQTRDLLYVEDCARFVVEAGYSNAVNGEIVNAGLGRDISVNDLAKLIVGDEDRIRHVEHIHPQSEIQKLLCNSDKAGKLLGWKAEVTLEEGVRRTEEWISKSDLIALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPF5</accession>
    <name>A0A398CPF5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribonuclease 3</fullName>
            <ecNumber evidence="10">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Ribonuclease III</fullName>
            <shortName evidence="10">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rnc</name>
        <name evidence="14" type="ORF">D3H35_07720</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="10"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04463">
        <property type="protein sequence ID" value="RIE04463"/>
        <property type="gene ID" value="D3H35_07720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="PTHR11207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 10 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="10" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="RNase III" evidence="13">
        <location>
            <begin position="7"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="12">
        <location>
            <begin position="162"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE04463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="246" mass="27416" checksum="6B9F27404207E2A4" modified="2018-12-05" version="1">MKEADSFRRLQDRAGVSFGNASLLRQAFTHTSYVNEHRGARTEDNERLEFLGDAVLQITVSEYLYRSYPHRPEGELTRLRASIVCEPSLVRFAEALEFGQVVLLGKGEEQTGGRTRPSLLADAFEAFVGALYLDQGIEAVRVFLERHMFPQLPEGGQAPLKDFKTELQEKVQQLVLGPLDYRIVEERGPAHDREFVAVVQIGEKRLGQGIGRSKKEAEQQAACQALGTLATDGNSNGMTINERRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPM4</accession>
    <name>A0A398CPM4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TerC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04130">
        <property type="protein sequence ID" value="RIE04130"/>
        <property type="gene ID" value="D3H35_08370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022301">
        <property type="entry name" value="Integral_membrane_YjbE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03717">
        <property type="entry name" value="R_switched_YjbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="233" mass="24790" checksum="1DF6757A53E87DEE" modified="2018-12-05" version="1">MENLLLLAEILLVNIVLSGDNAVVIAMASRNLPDDLRKRAIWWGAMGAVALRIVLSIAAVALLDVPSVRIVGSLLLIYIAVQLLTDDGEAKEVRSSASLGKAIGIILLSDLIMSLDNVLAIASIAHNNLWLMALGIALSIPLIVWGSQLILKVLHRFPALVWIGAAVLGYTAGEMLEGVDAVERILPGWGAWGLGWVPVAAAAVTLLAGAVWRRLASRKADKPALKLHTKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPQ5</accession>
    <name>A0A398CPQ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000026">
        <property type="protein sequence ID" value="RIE04523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04523">
        <property type="protein sequence ID" value="RIE04523"/>
        <property type="gene ID" value="D3H35_05835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="214" mass="22885" checksum="A1DB593FB0D44167" modified="2018-12-05" version="1">MLAGIRRAGVAGMFVVWNVNPYTSVLSSLEIPFFVHITIDCAVIFAVLAITVWLWFLSAVVPTVARRTGGNPIRMVVLAASETRKNVRLWSMLPLTACIHLISWAVAASCGGAAQAIAGLANGWVELLLLAGLLRVSKFAPLAAPRQAADSTVTVVRGRRTALIAIAALNLLLFGSTAFCSYREDIPLGKSVDVSAQYSQRSGNRSDFLAAWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPR6</accession>
    <name>A0A398CPR6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000006">
        <property type="protein sequence ID" value="RIE05406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05406">
        <property type="protein sequence ID" value="RIE05406"/>
        <property type="gene ID" value="D3H35_00525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="82" mass="9213" checksum="2A807B5C1C76A058" modified="2018-12-05" version="1">MERRLVPLTIPANGRSALVERTEMAAPEFPRLRATFRHGLQCSPEDDPAAFASVGRLKAEEEALAIMERRIPRGPTYLADFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPX8</accession>
    <name>A0A398CPX8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">O-acetyl-ADP-ribose deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04492">
        <property type="protein sequence ID" value="RIE04492"/>
        <property type="gene ID" value="D3H35_06905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="171" mass="18509" checksum="12894876EED87C8F" modified="2018-12-05" version="1">MIEVIQGDITKASLDCIVNAANTSLLGGGGVDGAIHRAGGKQILDECIRIRNAQGNCPTGEAVLTTGGRLHAKYVIHTIGPVWNGGQSHEPEKLSSCYRNTLNLAVEKGIKSIAFSNISTGIYGFPKDKAAEVALKTVADFIEKNATIERVQFVCFDRDNYDIYLERLRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPY1</accession>
    <name>A0A398CPY1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="5">IGPD</shortName>
            <ecNumber evidence="5 6">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">hisB</name>
        <name evidence="7" type="ORF">D3H35_21470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="5 6"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01024">
        <property type="protein sequence ID" value="RIE01024"/>
        <property type="gene ID" value="D3H35_21470"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="203" mass="22645" checksum="F9ED557DA0D0A891" modified="2018-12-05" version="1">MSEFTQENQGRKGSVSRKTNETDIKLSLNVDGSGQVGLETDVPFLNHMLDLFAQHGQFDLNVEARGDVDIDDHHTVEDIGICLGQVLRESLGDKKGIKRYASVFVPMDEALAQVVVDVSNRPHFEYRAEYPSAQVGSFQVELVHEFLWKLALEARITLHVIVHYGRNTHHMIEAVFKALGRALDEATLIDPRVKGVPSTKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPY7</accession>
    <name>A0A398CPY7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PLP-dependent aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_03610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04595">
        <property type="protein sequence ID" value="RIE04595"/>
        <property type="gene ID" value="D3H35_03610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="281" mass="30184" checksum="576E584D61C3C2F4" modified="2018-12-05" version="1">MLPIDYSGQLARFGIKHVALYEAIREAIADGTLAPGERLPSTRTFAAEYGLSRGSVSLAYDMLASGGYLRAGIGQGTFVAGSPGTKRPDNNRCEDGDRAAPAAPRLSSWGKRIAAMYEEERLTERGANEAGSADIRVSFVPQGIGSRWFPWAEWRAVTAARWKKLGASGEDGSSDPAGSMGLRRSIADRLRRERGITCDPGDIVLTSGSMQAIALVSQILLEEGTNAVVENPGYSGIRRAVRMSGARCVEGNVDECGIVPEDWDADLLFVTRRGSFRRAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQJ9</accession>
    <name>A0A398CQJ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper amine oxidase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04440">
        <property type="protein sequence ID" value="RIE04440"/>
        <property type="gene ID" value="D3H35_07600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="109" mass="12006" checksum="50D737360454DD6C" modified="2018-12-05" version="1">MQIGSLTALVNGKSVILDAAPFIRNGASYVPLRFASQSLGLLVQWYSAEKVIRLSTNYVTLNIKNVLGDKVTNEEVSVRLLAKEPQQEPYSLDHRQATMEMTAAAGKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRN7</accession>
    <name>A0A398CRN7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphonate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_01450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05213">
        <property type="protein sequence ID" value="RIE05213"/>
        <property type="gene ID" value="D3H35_01450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017394274" evidence="2">
        <location>
            <begin position="25"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="356" mass="38014" checksum="EB57A91A99F56BE0" modified="2018-12-05" version="1">MKKALGLVLTVALVLAGCSSNSDSNSNNSSPSKEQAGTKTKDKLTMVWYPNESGPEIKPARDAIGKIIEEATGKKVEHQTTTDYIIAIEALASGNADIAYMGPQGYIEANAKNDKVQPLVVPSGESGTLNDAIYHSWLNVRKGEDGAYKSGDGYSLDNIVGKKFSFVSNSSTSGFKVPTAGIISYFGKQDAYKSLTVDDLLEGGKGKFFSEVLYGGSHQGSAVNLLTGKADIAAFCDTCVSNYVELESGKENEPGAVYKVKEGAAEPFNTLVGKQFTIISDTPVLNSPFAVNTDSISAEDIQKLKDAFTSDAVAKNPVIFLPKDSKDSGLLKQKSGNEKFVTVEDAWFDPIRQLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRP9</accession>
    <name>A0A398CRP9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_24995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01604">
        <property type="protein sequence ID" value="RIE01604"/>
        <property type="gene ID" value="D3H35_24995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="240" mass="26594" checksum="95F42D06EF682002" modified="2018-12-05" version="1">MIQVTSLSKSFGKTKVLKEITLNINKSEVVCIIGPSGSGKSTLLRCMNKLENPSDGDVVVNGRSLIDRKVDINKLRENIGMVFQSFHLFPHMTALENVMLVPVELKKATKSQARENALRLLGKVGLKDKADEYPDRLSGGQKQRVAIARALAMNPDILLFDEPTSALDPEMVGEVLQVMKDLAQEGMTMVIVTHEMGFAREVGDRVIFMDEGAIVEENTPAELFSNPRNARVQEFLKKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS54</accession>
    <name>A0A398CS54_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Taurine ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_11055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03568">
        <property type="protein sequence ID" value="RIE03568"/>
        <property type="gene ID" value="D3H35_11055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd13560">
        <property type="entry name" value="PBP2_taurine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010068">
        <property type="entry name" value="Peri-bd_TauA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF38">
        <property type="entry name" value="PTHR30024:SF38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017275563" evidence="6">
        <location>
            <begin position="35"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="7">
        <location>
            <begin position="44"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="348" mass="37474" checksum="2B5AA7C785B52A9D" modified="2018-12-05" version="1">MKNKNRNRNRKALWSVLALVLMLSLVLTACGSNKSEGSGKLPKEVTIGFQVIPNAELLVKAKQLAEKKFPDTKINWKPFDSGRDVNTAIAAGGIDLGLAGSVPVSIGVANKLPYQVYFLHDIIGDAESLAVRNASNIKSVKDLAGKKVAAPFGSTAHFSLLSALKLEGVDPASVTILDLQPQDILAAWQRKDIDGAFVWNPVLAKLLAEEGSVLVSAQQLSEKGAITADVGVVRKAFADDYPDFVKGYVSVLDEAVKLYRDKPEEAAKALAPLLSTDEADALAQTKQLVWLTSKEQQDAKYLGSKKEESGFADVLLETGKFLVDQKQIPSAPSLSDYQSAINQEALKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS79</accession>
    <name>A0A398CS79_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000006">
        <property type="protein sequence ID" value="RIE05403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05403">
        <property type="protein sequence ID" value="RIE05403"/>
        <property type="gene ID" value="D3H35_00500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="68" mass="7799" checksum="053A3D92D3A78AEB" modified="2018-12-05" version="1" fragment="single">MRMLTEMENEGKILLTRTDRYGVPERYELAAGRLQPIRRLRFPAAGEPDHPDVYIHANDLQSAMNGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSR4</accession>
    <name>A0A398CSR4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit J</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02004">
        <property type="protein sequence ID" value="RIE02004"/>
        <property type="gene ID" value="D3H35_14655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="175" mass="18950" checksum="F211C252FC16D58E" modified="2018-12-05" version="1">MFNFNVDFTGEFVAFFLLAVCAIVGAVMALQFTKVVHTALSLAFTFVALAGLFVLLDAEFVAFVQVLLYVGAVTILMIFGIMMTKHQDEGQEPSRPLRDTLAAIGCLCLFGILFYAIRNAGFPAEARPGDENNTLEIGKLLFSQYAIPFELVSVLLTVAFIGAVALAKREEGDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSU1</accession>
    <name>A0A398CSU1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Recombinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_16920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02391">
        <property type="protein sequence ID" value="RIE02391"/>
        <property type="gene ID" value="D3H35_16920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="3">
        <location>
            <begin position="158"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="418"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="510" mass="58027" checksum="0FD171058A725B47" modified="2018-12-05" version="1">MRCAIYARVSTKRDEQRNSLDNQITYTTNIVKDNAWQLAGTYIDDGISGTTFLKREAIQQLIHDAKKKKFDVVIAKSVSRFGRSSVESMTVADELEQRYNIRLIFPEDNYDTATSDTKFMFRLKAILAEEESRKLSARIKIGRQTGARLGKYQASLTAFGYKRGDDGKLTLDEQYSPIVREMFDLYLYKGWGWYRIASHLNSRKVPTPRTVSGGSNKGAMWLESSIRVILENVVYTGALVQHREETMDFISKKRKTVAPDKQIIVKDAHPAIITHEEHIAALEKMRAKGKHKYNGQESTFAHVARCADCGKGMMYRKDRLGKEGDAYVCGGYVKHTSAYCSSHIIANNKLMDTIKADLQELITNNVRMEQLYNIAGGELELNQTSYTKELQGVNKQLAKREGEFRSLLTLFQQKAIGIEQFKSTNENIQSEQSRLTARKTELEALIESKKDTERYLQDFQRQVNKIAKLDIANEQVLKHIIQKLINKIEVHADGSVKIIYNIARPASLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSZ7</accession>
    <name>A0A398CSZ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05280">
        <property type="protein sequence ID" value="RIE05280"/>
        <property type="gene ID" value="D3H35_01815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="336" mass="36966" checksum="E62B3B01C8E08237" modified="2018-12-05" version="1">MERQPIEIAFERYRAESPEPAKRAAAALKRLLAGVERSLWPEVAWQFSSLTGDGFPVELAFTSTGEAIRYVVDPSGPEIDSSMRLRRALAVIEELRGTNSSATTERIRPSFAGAGDFYSHAERLLRIQSSGGGLAYGAWIGGRHDSDGDRFKLYAEVPQGSSTEADEWVRSVLGDRPLLLGRPPILRMVGLEPDSGRIEWYFRVERMEPWEISRIMGMLGKSEQGEQLLGLVEEFAERSVATSLPCTRNGFSISTDANGAPSVFSLFCLAKRLAGGDGRIRGKLLNIAARRGWPLKHYEAISAPLADREGTRTKHGILSFVAAPENSVQLHVGLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSZ8</accession>
    <name>A0A398CSZ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_20285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02947">
        <property type="protein sequence ID" value="RIE02947"/>
        <property type="gene ID" value="D3H35_20285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="9"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="113"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="174" mass="19707" checksum="C6C8359ADC992855" modified="2018-12-05" version="1">MDIEELSNLVKLHGKAIYAFCYKLAGNKTDTDDLYQETFLKAMEVRHKMDPNQNPKGFLISIAIRLRKNNRRKFAWRQRIAPLAGLNEAVDNASGLEGEATPEEAVLSQELRGMIQAAADRLDDKLKLPLYMYYTAEMSVEEIASALQIPAGTVKSRLYQSRKAMKKLLEVESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT01</accession>
    <name>A0A398CT01_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="5 14">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D3H35_07925</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="5 14"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03888">
        <property type="protein sequence ID" value="RIE03888"/>
        <property type="gene ID" value="D3H35_07925"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="8 14 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="11">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="11">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RIE03888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="330" mass="36002" checksum="6C0771A547A31758" modified="2018-12-05" version="1">MTFPVTRNRRLRNSASMRSLVRETILTANDFIAPIYIVPGTGIKHEIRSMPGVFHFSLDTVEQELSELVSAGIRSVLVFGVPDSKDAVGSSAYAEDGIVQQGIRRIKQLYPELIVIADTCLCQFTDHGHCGVVHHTADGPVIDNDDSLALLARTAVSQAKAGADIIAPSNMMDGFVAAIRAGLDEAGLSHVPIMSYAVKYSSAYYGPFREAAHSAPQFGDRKTYQMDPANVREALREAQADVDEGADFLMVKPGLAYLDVLRLLKDRFDLPIAVYNVSGEYAMVKAAALQGWIDERAIVLETLTGMKRAGADMIITYHAKDAARWLNEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTG3</accession>
    <name>A0A398CTG3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_13620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03127">
        <property type="protein sequence ID" value="RIE03127"/>
        <property type="gene ID" value="D3H35_13620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="86"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="268" mass="30132" checksum="273064005E4C255B" modified="2018-12-05" version="1">MLGSVSDAEDAAQDLFADLYAADSRNIKNPKAYLAKWTMNRCLNVLRSSRRKRELYVGEWLPEPFSESSGLPELEAEQNDSLSYAYQVMLEKLTPTERAVFLLREAFEYDYEEIADILGKSATNCRKIFSRAKAGMQDVSAAADTPLIRSPIVEKFVEAFQHYDVERLLELLAQDATMILDGGGRVNSAIHPILGRKRVIALLTSPKALIKPRSVWSHSLTLVNSETNIVFSEDGVARGVLCIELTPERDRIRNLYMVLNPDKLHGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTJ3</accession>
    <name>A0A398CTJ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_17285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03167">
        <property type="protein sequence ID" value="RIE03167"/>
        <property type="gene ID" value="D3H35_17285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528">
        <property type="entry name" value="PTHR31528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017434936" evidence="1">
        <location>
            <begin position="32"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="47"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="332" mass="36497" checksum="06F967CB1D79B982" modified="2018-12-05" version="1">MKFRQWKKSAWLSTALALVLIAAGCSSNKQAEPAETELTVLLDWYPNAVHTFLYAAEEQGYFKEAGLKVKLQTPADTNDALKLVATGKADLALSYQMQVAISRSEDIPIVSVGAIVRHPLNQLMALESSEIHSPKDLIGKKIGYPSIPLDEAIVNTMVKSDGGDPSKLTYVDVGWDLIPAMTTKKVDAIIGGYVNHEKLLLEKEGEKLITFDPSQYGVPDYYELVLTASEDGLKSKSDAIKKFLAASAKGQEYTVSHPNEALQNLLDKQSTEFPLDAEVEKKSLAILLPLMDAGTEPFGSQSEQSWSSILNWLTEHGQLKKEVKAEQAFRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTV1</accession>
    <name>A0A398CTV1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02394">
        <property type="protein sequence ID" value="RIE02394"/>
        <property type="gene ID" value="D3H35_16940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="235" mass="28188" checksum="8AF6977D9F01F076" modified="2018-12-05" version="1">MYEYMVKTLYKNIEWITKLDKLYSDQLNGMNNSNYLYYPDIELDLITENIFIIFQKSNRKTKIIFGDKYGRRAYLSDVDIINMIRDAEDTVYGIFCEILTLFVMEPETNDIHFKINEESFYYKSIVKNSYEPSKLEILRLNFFDSAADIKISYLDLLTLINLVITKEYLVDSSRSDIRVLRQAKKFLILSKFYKEKLYQEELERFEFDTSQAIEYVYKNNKIAKKIDELFDKITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUQ2</accession>
    <name>A0A398CUQ2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsJ</name>
        <name evidence="6" type="ORF">D3H35_02235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE04989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04989">
        <property type="protein sequence ID" value="RIE04989"/>
        <property type="gene ID" value="D3H35_02235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="102" mass="11641" checksum="1CB33952739463CB" modified="2018-12-05" version="1">MAKQKIRIRLKAYDHRVLDQSAEKIVETAKRTGAGVSGPIPLPTEKQIITILRAVHKYKDSREQFEMRTHKRLIDIVNPTPQTVDALMRLDLPSGVDIEIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUV1</accession>
    <name>A0A398CUV1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_19300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02784">
        <property type="protein sequence ID" value="RIE02784"/>
        <property type="gene ID" value="D3H35_19300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01068">
        <property type="entry name" value="globin_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039379">
        <property type="entry name" value="Protoglobin_sensor_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="2">
        <location>
            <begin position="164"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="335" mass="37901" checksum="99F996F6EFCD0EC1" modified="2018-12-05" version="1">MIRVTGARLAQLRYIGITDEDMSFLKSKHNEFAKITNAVVDELYNKITLQPELVKLIEEHSTIDRLKETQRWYFQSMTAGLIDDQFIEKRIFIGKVHSRIGLTTNWYLGTYILYLDIATAHFKRIAPDDWANIVHSLTKMFNFDSQLVLEAYESDEKAKIEQLVDQQQEILRGISAAIQDLVALIADLNRSSEAVASTAIQTAESQDKSHNHLIELNKEIKDVHQIGTFMRDMSDQTHLLSLNAALEAARAGDAGRGFEVVANEVRKLAAGSKDSLKNIQQKLKKITDVLALVQNESEQTSVYSREQAASSEELASFVHMIQNVTEQLEVLKQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUX7</accession>
    <name>A0A398CUX7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03101">
        <property type="protein sequence ID" value="RIE03101"/>
        <property type="gene ID" value="D3H35_21225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="112" mass="12859" checksum="44A59F5357A1629D" modified="2018-12-05" version="1">MEQFDLKEMQIRIEKIKEKIHELANDPLRENLKEFYMMGLITPLLDELGADPAVIVGGHAVELYTSGSYKTVDVDLVLERDDLARRLFDKLGFLREGIPLRSGFGYSDRNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVK0</accession>
    <name>A0A398CVK0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_05550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04558">
        <property type="protein sequence ID" value="RIE04558"/>
        <property type="gene ID" value="D3H35_05550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="PTHR11592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="158" mass="17803" checksum="D21C4ADA1F48AA0A" modified="2018-12-05" version="1">MSIYDIEVKTIRGAAKSLDEYKGNVMLIVNTASKCGFAPQYKGLQRLHEQYSEQGLVVLGFPSNQFANQELEDESAIEQHCEINHGVTFPLHGIVDVRGQEAHPLFRHLTKAAPGFLGSKAIKWNFTKFLVDRSGRVVRRFSPTVTPEKIEAHIRKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVK8</accession>
    <name>A0A398CVK8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05349">
        <property type="protein sequence ID" value="RIE05349"/>
        <property type="gene ID" value="D3H35_00730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="209"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="284" mass="29563" checksum="BC5A1E5EC81F6DCD" modified="2018-12-05" version="1">MCIGQAGDKIDCNSKDGLGDLTNLKVELSGTNVEAFELTQPAAATLTKGKPVTTFTVKAKDGLASGTYTATLTVKADEIADATFAVTQVVNETSTNTYTIEALEDQTLSALTAGYTPGTQETKTVAVTRTGTGDLSNLAVSLTGANAADFVITQPAASLLNEETPSTTFTVKAKDELAAGTYTATVTVKANNLTDATFTVTQVVNLPNAPANPQNLTAARGDRQVTLNWNTVTGATYYNVYMATASGQFSQSALATVTNPTYNVQNLTNGTTYYFVVKAGSLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWB0</accession>
    <name>A0A398CWB0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 4">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">galU</name>
        <name evidence="6" type="ORF">D3H35_09190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 4"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04107">
        <property type="protein sequence ID" value="RIE04107"/>
        <property type="gene ID" value="D3H35_09190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01099">
        <property type="entry name" value="galU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="5">
        <location>
            <begin position="6"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="293" mass="32691" checksum="A25A48FB308E0144" modified="2018-12-05" version="1">MSRIKKAVIPAAGFGTRFLPATKAIPKEMLPIVDKPAIQYIVEEAIDAGIEEIIIVTSRNKKAIEDHFDRNHEIEQFLYEQNKIQLLNLLKDTVHSEIQYVRQRQALGLGHAVWCARKFIGDEPFAVLLGDVISVEGTSCLKQLIQTYEETKSSVIAVHPVDWADVSGYGVVSGKHVKNGLVNVERLVEKPKSDPPSNLAIIGRYILEPEIFPILERLSPGEGGELQLTDALQELIKHKELHACMFTGKTYDVGNKLGYLKATVELALEHDTLQKPFTEYLQQIASKRGGSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXF8</accession>
    <name>A0A398CXF8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Phosphate acyltransferase</fullName>
            <ecNumber evidence="3 4">2.3.1.274</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Acyl-ACP phosphotransacylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Acyl-[acyl-carrier-protein]--phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phosphate-acyl-ACP acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">plsX</name>
        <name evidence="5" type="ORF">D3H35_07690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.274"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Probably interacts with PlsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Associated with the membrane possibly through PlsY.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PlsX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.274" evidence="3 4"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04457">
        <property type="protein sequence ID" value="RIE04457"/>
        <property type="gene ID" value="D3H35_07690"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043811">
        <property type="term" value="F:phosphate:acyl-[acyl carrier protein] acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00019">
        <property type="entry name" value="PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003664">
        <property type="entry name" value="FA_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012281">
        <property type="entry name" value="Phospholipid_synth_PlsX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30100">
        <property type="entry name" value="PTHR30100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02504">
        <property type="entry name" value="FA_synthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002465">
        <property type="entry name" value="Phsphlp_syn_PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00182">
        <property type="entry name" value="plsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="329" mass="34902" checksum="FBFE71377A516FC6" modified="2018-12-05" version="1">MRIAIDAMGGDHAPAAQVEAVLSSAAEWPDTEFILVGRAEAIEPLLAGKRHPNVAIEDAKEIIEADDEPVRAVRRKADSSMVVAGRMVKEGRADAMISAGNTGALMAVGLLVVGRLKGIERPGLTSMLPTLDDVGVLVLDLGANMDAKPEQLLQYATMGSIYREKVNGLKKPRVGLLNVGTEAAKGNELTKAAFELLEKAPIHFVGNVEARDVLEGVCDVLVCDGFSGNILLKAMEGTASATFKILREELTSSWKNKLAAAVLKPSFRKVRTKMDYNEYNGAPLLGVNGLVIKGHGSSNARAMKTAIRQARAAIQGGVIAALEGEIRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXS0</accession>
    <name>A0A398CXS0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Paeninodin family lasso peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03784">
        <property type="protein sequence ID" value="RIE03784"/>
        <property type="gene ID" value="D3H35_09530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="40" mass="4450" checksum="E04865B4DF876D8A" modified="2018-12-05" version="1">MNKEWKQPSLEVLDVKMTFAGPGVTIPDSLDPDEATQHHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY53</accession>
    <name>A0A398CY53_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03924">
        <property type="protein sequence ID" value="RIE03924"/>
        <property type="gene ID" value="D3H35_08140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="62" mass="7281" checksum="3F874EDB239AB559" modified="2018-12-05" version="1">MVVLNHEPLFSSVEFFITRFFVGIDLILEQETRVPLPTICVNEIVGIFDKEYLVKKRMFGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYE4</accession>
    <name>A0A398CYE4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_08650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04014">
        <property type="protein sequence ID" value="RIE04014"/>
        <property type="gene ID" value="D3H35_08650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="21"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="260" mass="28912" checksum="6226C281D1424820" modified="2018-12-05" version="1">MGAQFDIAYVFEYAVKLLPFIRISLLIVAGSLVVGLGVGFLVALPRLYRIPVLQRLSQIYASFFRGTPILIQLFLFYYGLPEVLKLIHVDVSRVPVLYFVILTYGLHSAAFISEGIRAAVTSVDRGQIEAAYAIGMTGPQAFARIVFPQALAISIPIFGNVTIASLKDTSLAFTLGVMELTSKSQSLGQLTRHFIESYIALAIIYLLISILLEKAFHYVERRLLRHEDQEVATKKFAIARQWLSRRLGAKVTLREGGSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYQ6</accession>
    <name>A0A398CYQ6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carbam_trans_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04967">
        <property type="protein sequence ID" value="RIE04967"/>
        <property type="gene ID" value="D3H35_03250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003696">
        <property type="entry name" value="Carbtransf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02543">
        <property type="entry name" value="Carbam_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbam_trans_N" evidence="1">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="109" mass="12176" checksum="C25097F16039761D" modified="2018-12-05" version="1">MKIIGINGWSEKFDDPATRGHDAAAVLLVDGRVVAGIEEERLTRVKHTGKIPISAIRFCLNYGNYSIRDIDYIAISISESSLNVNIKLDKLYHPEQKTWTGTSNLIFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ60</accession>
    <name>A0A398CZ60_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05137">
        <property type="protein sequence ID" value="RIE05137"/>
        <property type="gene ID" value="D3H35_02895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="180"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="385" mass="41075" checksum="92C5ADC5970B5048" modified="2018-12-05" version="1">MSEQERETTVRFYRHLHRHPELSFEEQRTSALVAEELRKLGYRVRERAGKFGVIADLEGAADGPTVALRADMDALPIEEETGLPFASTVPGVMHACGHDAHTAMLLVAARILASHRGELRGRLRLLFQSAEEINAGAKAMIGDGGLEGVAEIYGLHNWPALPAGVAAVKEGALMGAVDRLDIEVRGRGGHGAIPDLAADPIVASSAVVLALQTAVSRELSPFEPSVVTIGSFHGGHANNVIPDRSLLTGTVRTLSPKARADIRGKLIRLISKTAEAYNCSAEVEYTEQVPAVINDSGCAVAVREALVRTFGTERVRTADPTMAGEDFAVYQERVPGCFFWIGSGPKQGSEAAYGLHHPKFRIDEDCLPAGVAALVSIALARLAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0S4</accession>
    <name>A0A398D0S4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_02930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05101">
        <property type="protein sequence ID" value="RIE05101"/>
        <property type="gene ID" value="D3H35_02930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="66"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="306" mass="34054" checksum="064088644336D9E0" modified="2018-12-05" version="1">MTWIRRKPFLWFILPGFVLYSLFSVYPILSAVQISLNKWDGIGAKTFVGFDNYIELFSNPELFDQLANALTHSATIFALNAFVVLPAQLYLAYLLHGKIRGHRFFQAMIFSPQFIATPVIAFMGALVFDGNIGVFNKLLETVGLGEWTRPWMGIPELGIYIVWALVAWSGIGVGMIFFLGAMKMISAEIIEAALLDGASYWGRFFRIILPQIKTTILNMLILTYIFAMTLFDFSFILGGAAGGINRSVDVMALFFYRISFGDSSSVGGSSNVNAMGMGTTIACVMFVIVFAVALVQVFFVYRRSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D164</accession>
    <name>A0A398D164_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000022">
        <property type="protein sequence ID" value="RIE04914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04914">
        <property type="protein sequence ID" value="RIE04914"/>
        <property type="gene ID" value="D3H35_03550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="40"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="243" mass="27430" checksum="FB21500CDAFB1059" modified="2018-12-05" version="1">MPDHAKIYLEEAEKYARLIASQPPLDGVIEEIRPFEGLDIVDIGAGTGRLSAVLAPRAKSLVALDASQAMLNETARQLSEAKLSNWRTEVADHRRLPLEDGCADLVVAGWSVCYLASADAPDWEDNLRIVMSELKRIVRSKGTIILFETMGTGVETPAPPDFLLPYYAQLANLYGFAHRWIRTDYLFESTKEAEEMTRFFFGDELGDRVAREELLRVPECGGVWWLMRIDPERFLHGICDSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1I5</accession>
    <name>A0A398D1I5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_02595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05044">
        <property type="protein sequence ID" value="RIE05044"/>
        <property type="gene ID" value="D3H35_02595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="33"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE05044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="279" mass="30464" checksum="DA044C2C964D1913" modified="2018-12-05" version="1">MSLIATGKETHPGAALSDIGGNRQAEKEVAPLLSLRNVSKAYGNGTVAVRNVNLAIREGEIVSFVGPSGCGKSTLFRMIAGLGSPSEGTIDILGRTPEQSRREGGVSYVFQDATLMPWSSVLDNVTLPLKLSGTAKRDRLERADRVLELVGLKDYRKALPRQLSGGMKMRVSIARALISNPKLLLMDEPFGALDEMTRQSLQDELLAIREKDPRMTILFVTHNVFEAVFLSTRIAVMSVRPGRIAKEIEVDVPYPRGHDFRTTPEFGELVRSVGAVLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1X2</accession>
    <name>A0A398D1X2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_02950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05104">
        <property type="protein sequence ID" value="RIE05104"/>
        <property type="gene ID" value="D3H35_02950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="159"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="305" mass="34753" checksum="4786F150B6E16E87" modified="2018-12-05" version="1">MSKPRLIAEPVAGWPRLPEDLKLGYTHGIAVDSQDRIYVFNMSRHAVVVLDPTGSYLHSWGEEFALGAHGMHLSQESDGGEYLYLTDIERHLVAKYTLDGRELLTLGAPPSSDTYPSPERFVPTDVDVAPNGDIFVADGYGQYFIHRYDSNGTWLGCWGGKGSDDGQFQEPHGLWIDSRGSEPLLYVADRRNQRFPCFTLNGKLLHTYTGDYLLPCDLVGDGERFYIPDLNSRVTIADSRLQIIGHIGEQPHHWQDERWPDIPEAEWTDDRFISPHALCLDRQGNLLVVEWVPRGRIMKWKIRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CAR8</accession>
    <name>A0A398CAR8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_29825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00236">
        <property type="protein sequence ID" value="RIE00236"/>
        <property type="gene ID" value="D3H35_29825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="5">
        <location>
            <begin position="160"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="225" mass="24562" checksum="87A6173765DDA164" modified="2018-12-05" version="1">MIHVLLADDDPFIRESLKLILGLNQDLSVVDTCTNGEEAFQAIGRFERVDVVLMDIRMPECDGVEGTRRIKQAYPDVKVLILTTFDDDEYIIEALRNGASGYLLKNISPDRIIDGIKTVHQGNLLIHPDIAAKLTSFIGGPASASALSSTAASASAVTARPLSDFGLTPSEQAVVEKIADGLSNKEIAQQLYLSEGTIKNYVTEILGKLNLRDRTQIAIFYLKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBA9</accession>
    <name>A0A398CBA9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_28930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00436">
        <property type="protein sequence ID" value="RIE00436"/>
        <property type="gene ID" value="D3H35_28930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="127"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="127"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE00436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="225" mass="25859" checksum="1AAFE9C4BFA9EB46" modified="2018-12-05" version="1">MKKILLIEDEKNMSRFIELELRYESFAVTTASEGNAGLQFALAEDWDIILLDLMLPGIDGLEICRRVRSIKYTPIIMLSAKDSVTDRITGLDCGADDYLPKPFAIGELLARMRVVFRRQREIQGERLPVLSFQGLSLDPNTRLVLREGESIDLTKREYHLLEVFLGNVNRVLDRETLLDKVWGFETAVDTNVVDTYVRYLRRKIDLAGQPSYIQTLRGIGYVMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBK2</accession>
    <name>A0A398CBK2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">secD</name>
        <name evidence="10" type="ORF">D3H35_27735</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00536">
        <property type="protein sequence ID" value="RIE00536"/>
        <property type="gene ID" value="D3H35_27735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE00536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="417" mass="44594" checksum="F113E2DD5CB5C195" modified="2018-12-05" version="1">MNRLLAFVLVVVVTFGVIGFTTPGLLHNTKLGLDLKGGFEILYEAEPLTPGGQVTKDSLKQTAISLEARANKSGVSEPEVTTEGENRIRVKIATGKGDEDAVRDLMKRPADLEFRSASGCSSATDYCKVELVGGDFKENAATTGFDSLNRPLVNIVVKEKSKLAEVSSRLVGQNLAIFLDGVLQSDPVVQSALTDGTAQITMIESMDKARELAKVINLGALPLKLTEKYTQSVGASLGQKSLDQTLFAGGLASILILLFMLALYRLPGLIASICLITFVWLLLGVFWLMGATLTLPGIAAFVLGIGIAVDSNIITAERIKDEIRHGKTVASALRSGAKNSFRTIIDAHITTIIAAGVLYFMGHGIVKSFAIVLIASIIANILTNVFMPRFLLQLLVRSGRFTKPGLYGVKESEIGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBY5</accession>
    <name>A0A398CBY5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000061">
        <property type="protein sequence ID" value="RIE00293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00293">
        <property type="protein sequence ID" value="RIE00293"/>
        <property type="gene ID" value="D3H35_29410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="170" mass="17789" checksum="96440F2D21E85CB1" modified="2018-12-05" version="1">MADLTLTVQGSQVKLVWGDPPAGSGTVSALRILRKLGTGDWQTLATVADAAARSYTICPQRRANVFICHSRSGRQRAAISVFVEKTVDIGGFAISSSTTRCVLFPADAGQGDKVKLTAGWRGAGGQGRLALLDVNGVNRTLQSALVEAAETGYIQRRARCARGCGQAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CC38</accession>
    <name>A0A398CC38_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycoside hydrolase family 125 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_28340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00340">
        <property type="protein sequence ID" value="RIE00340"/>
        <property type="gene ID" value="D3H35_28340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901575">
        <property type="term" value="P:organic substance catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="PTHR31047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028846">
        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="439" mass="49809" checksum="08101202AACDE6F7" modified="2018-12-05" version="1">MEKFRLPRISLRPPELPDSVRAVLAEAEERLAGRPKLLNLFRNCFPNTLETAAKLMDDGTTFVLTGDIPAMWLRDSVEQVIHYVPLAAGDPGLQRIIGGLIKRHMACILIDPYANAFNETANDWHWNAADGTDMGPWVWERKFELDSMCFSIRLAYLYWKETGLADIFNADFKKAMRTIVDVWRTEQRHGELSEYRFTRDDGEAEDSLPNGGLGMPVNYTGMIWSGFRPSDDPCDFHYNVPANLFAAVSLRQLGEIAKWVFRDEPFVREIARMEAEVRRGVELYGIYRHPEFGPIYAYETDGFGNYCLMDDAGTPGLLSIPYLDPSLADDPVYANTRRFALSRSNPFYYEGKAARGIGSPHTPPNYIWHMALSMQGLTASDPAEKLEMIAMLEATDAGTGYMHEGFHADDPAQFTRSWFVWSNSLFSQLVHRAMKEGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCF3</accession>
    <name>A0A398CCF3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Shikimate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_28730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00400">
        <property type="protein sequence ID" value="RIE00400"/>
        <property type="gene ID" value="D3H35_28730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="310" mass="34379" checksum="EFA8A2110FB1CC74" modified="2018-12-05" version="1">MANHSTIYFIGVTTSASSGLQLFPKWAQQLGLSGMTMQGVDLPIDSPPADYLKWVKLIKEDPNSLGAIITTHKINLFNAAKEIFDDFDTYARMFGELSCIAKSAGRLFGYALDPVSSKLAMRRFLPDDLWAEKRGEALLFGAGGSALAVGAALLNKDNGHNVPSKIILTDINENRLIQARQKLAGLNPNVQIELSVSKSTLHNEECLGKLKPYSLIVNATGMGKDIPGSPISDRAIFPENSFVWELNYRGDLTFRRQAMNQQHLRALHIEDGWVYFVYGWIMCIAKIGALEIDDGMFERLEKIALERKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCG3</accession>
    <name>A0A398CCG3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00410">
        <property type="protein sequence ID" value="RIE00410"/>
        <property type="gene ID" value="D3H35_28780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="362" mass="40398" checksum="AA86A64AD8211F73" modified="2018-12-05" version="1">MIIGAGTISRHHAEAFKKLSKPEEAELYVTDLNEQALQDFCTQYPKARPCKDVDEMLALPVDDKDIVIVATPPRTHHDLAVKALRSGRHVLCEKPFAMNREEAEDMVRTAEELGLLIACCSARFLDVETTGHAIQLLRNGALGNVYRVEFVHKARRSRPGVEHLPALRWFLNRAVSGGGCLMDWGPYDFTTLNEVLEPTRIDVLSAWMANPETALAEDIKVFDIEEHVGAALRYHRKDGSTVIVEYERAACTHGKEYANVQLEGTQGAAYWDWLCYSGDGNITRVYDEDGKAKEETTSYSASPSMLTLMDKPLVFFDRTIRGQDAPSVVNRKALFNFAIIDAIYACIRTGAAQTIDLDSTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCM3</accession>
    <name>A0A398CCM3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00946">
        <property type="protein sequence ID" value="RIE00946"/>
        <property type="gene ID" value="D3H35_25635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="76" mass="8158" checksum="9897DADF13BB72AC" modified="2018-12-05" version="1">MVSGWGVCIVLAILLIGAVKKAKKWLVRFATVALVAAVAFVFYASTLSEDPAADDPASNIVKDTVHEVIKEIKSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCY0</accession>
    <name>A0A398CCY0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF350 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_29660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0719 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00275">
        <property type="protein sequence ID" value="RIE00275"/>
        <property type="gene ID" value="D3H35_29660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007140">
        <property type="entry name" value="DUF350"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03994">
        <property type="entry name" value="DUF350"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="126" mass="13580" checksum="1BD54B95E98A5848" modified="2018-12-05" version="1">MNVGIGLAILLVVLLVGAFVFSKLTKFNDGEEISKGNEAAGIYMGSKLLGLCIIVAMVSFSSHDWTSMLIWSGVGIVIQCLVYVLFDFFTPKFKVCEEIAKGNMAVAQLLRSIIIGTSIVIGTFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCZ9</accession>
    <name>A0A398CCZ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_21740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01056">
        <property type="protein sequence ID" value="RIE01056"/>
        <property type="gene ID" value="D3H35_21740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="391"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="6">
        <location>
            <begin position="445"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="734" mass="81003" checksum="A27AB52F6DF2B8A7" modified="2018-12-05" version="1">MFDWLGFKKGLPLWRSYRLNAGLKEDVENIFEGIAETRVQLLADWAGECWLHLERLRDQLDSVGDGSAGEGIKRLLAGTYSRAADFTEIFILDKPGAVVFSTYAPHIGVGYGEGSVLASGLNYARSDGKNGRPCLFGPYADPTTLAIGPRSSSFHDKMTLMFIFPIMKDGRWEGAIGARVPNDVIGDLIQRESGHVYPDSGDNYLFMAKAELNVHIVPGTALSRSRFEDRTFTHGENLKDGVTTDWGTVSVKEHTELELMFTDPATGQLHPGVANTIRNGHNLFVEFPGYSDYRHISVIGKGVTFKLPHCPDLWGMMCEGDLEEVYRGRGIAYRQLRPHIWLTVASAVLAAALVYLIALSASVPVIALCAFAFNLAFGFVTIGAIHGRSRRKVVDPLLRINRFIRINAEGKGDLTQRLDTAQFENDETRDLAKWINNMIDSLEGIMMKVKLAASDVTESQRLLGESTVTTAQSIDRVSGRIHDMVRSIRRQLKDIDVAKGVADEARETLQLLEQKASEQITVAQSEVGRIGDKMSHISDRVADTNGTIRVFRDTAHEIRSVLTVIEEISAQTHLLALNASIEAARVGEHGRGFAVVASEIRKLSELTKQSTEEVHEIIEKLSLHAQEAYASMEEGTRVVEEGTELVAAAVETLGAAKADDSQKARIIDEVVVLMEKIAAVSQDNRSISSEVEGKVQELQADIVDVRHTSRNVEAITALMEQLVGQFHLTETRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD60</accession>
    <name>A0A398CD60_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xanthine phosphoribosyltransferase</fullName>
            <shortName evidence="1">XPRTase</shortName>
            <ecNumber evidence="1">2.4.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">xpt</name>
        <name evidence="2" type="ORF">D3H35_27175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine</text>
            <dbReference type="Rhea" id="RHEA:10800"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.22" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00650">
        <property type="protein sequence ID" value="RIE00650"/>
        <property type="gene ID" value="D3H35_27175"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00602">
        <property type="reaction ID" value="UER00658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000310">
        <property type="term" value="F:xanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046110">
        <property type="term" value="P:xanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01184">
        <property type="entry name" value="XPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010079">
        <property type="entry name" value="Xanthine_PRibTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01744">
        <property type="entry name" value="XPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-phospho-alpha-D-ribose 1-diphosphate binding" evidence="1">
        <location>
            <begin position="128"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="190" mass="20712" checksum="21E051D8E2A778D1" modified="2018-12-05" version="1">MDILKERILKEASVINNDVLKLDSLLNHGVDPKLTMEMGKEFARRFADSKATKVITVESSGIPVAFATALELGVPLVFARRKKTLLGEPDAYCERVPSFTKGIVTDLLVSRHLLSSDDTLLFIDDIIANGDAARGLIKIIEQSGAQLAGIGIVLEKSFQAGGRALRELGLHVETLVRIRSLEGNVITFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD82</accession>
    <name>A0A398CD82_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_28565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00375">
        <property type="protein sequence ID" value="RIE00375"/>
        <property type="gene ID" value="D3H35_28565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="65"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="141" mass="16128" checksum="79DDFDF2D5438F21" modified="2018-12-05" version="1">MKRLKYPLYFSYPAIVVFMLFFIAPTIIGIYYSFTDWNINADTVKFIGFDNYAELFHEPRLKQAFINTLIFAAAVTVLQNGAGLALALILNEKLKTRNILRTIFFLPYVIAPLVIGYIFRAIYHPSMGLSINSSTWSGWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDM5</accession>
    <name>A0A398CDM5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Esterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01286">
        <property type="protein sequence ID" value="RIE01286"/>
        <property type="gene ID" value="D3H35_23150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="444" mass="49689" checksum="621E9076497C676B" modified="2018-12-05" version="1">MHSKIIAVEKFHSTILDNDRTIYIYLPSGYEQFADVRYPVLYMQDGQHTFHADERGGSWDLHLAADRLIEEKKIRPIIIVAVSHITDARISEYMHPLPGGEEVFGTKCHGEEYEQFLIQEVKPYIDEQFRTLKGPADTAVMGSSAGGLVSYNLGFRRPDIFGKVGALCPYFVRVEPTGEERWLSKRYKERPPIDIWIDVGEAEGYTVMEKHVRSAVDDMLEAGFEPGRNLWYYYVPGSGHTQKDWADRVHAPLLMFFGEIGQPVKAELAGPDRIGLSGLSARLNPIVTYDSGFVATDLNASYEIGDPSVLGVSPDGKLAPLREGTTTLTYRNGELASTLTVRVVPDLSATVNVSVHVEVPDDTPDVDILYAGIEIPKIGSNLYGGTFPVPRNMAFFFRISRGMGKDEADRDGNEVPMRFFKAKEGLALYYRVENWIDAKGDRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDM6</accession>
    <name>A0A398CDM6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR04086 family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00535">
        <property type="protein sequence ID" value="RIE00535"/>
        <property type="gene ID" value="D3H35_27715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023804">
        <property type="entry name" value="DUF3792_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12670">
        <property type="entry name" value="DUF3792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04086">
        <property type="entry name" value="TIGR04086_membr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="134" mass="14187" checksum="537C2C1C911EB416" modified="2018-12-05" version="1">MSAISRLFGIRIASPVLSGLIWSFIWLGIGALFLSFLLASTSVKEDGIPSLAIGIHGFASLCGGFVSARRAGRRGWYFGFVNGLLYTLLILLTSFLATDIDWTLRVLVVLGLTSLTGAFGGMLGVNSGGSSRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDU5</accession>
    <name>A0A398CDU5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_25850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000043">
        <property type="protein sequence ID" value="RIE00883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00883">
        <property type="protein sequence ID" value="RIE00883"/>
        <property type="gene ID" value="D3H35_25850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017458240" evidence="2">
        <location>
            <begin position="30"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="734" mass="81314" checksum="D3857B7EB44ABA24" modified="2018-12-05" version="1">MRKKLLVVTVLMSLIVGVVFSSFAGTAEAEETVGTETGTGSQQAPIPQPTIPESPITEVRENVAVESTSVKIIKVEQLEGYLSFGDVLTIRKQNSSEFAYNYMSDRDDHQWKVPVQDVDRSAIYDVVMATTFIEIDTGKIFLYYDKKVITGEQLLSMNAWLLKVSGKVKVSFDFGSLSEYNNSTKFYVGDGANDSQLEKGTGSDSRILMEPGKLNLTFLSNDENKSYHLSKSVNIQSDTVVSLTEQDIASANKIVFPSNTYSLGMYYYIDSVGTYREFSDTNELIVSKGTYSFYLYTKDSSNYYSWKSNKNNISNNKDYSVLNKPVLRLDTFEISDEGLNVEGSLVSGELSLLGVTDFYYNTISSQATLKDQGGNIVQEQQKIGRFWNSLTIPLDSPLQAGTYTLEFSVNYPGLAEPFQVNREVIVHSMDNNEIKGLVVEAEDESGEPLQNGHVMLFEKQLPNWSWFYSGYASNRTYDAGSIGDGKFFIPNAFLLAGKQYEVVVYGKSSDGMTDVFYNQPVSSGQANVKFTASSLKKLTFEASQAQAGQEVRVSLQNSDGLLVAWPFPVSFGADRKASMYIHTDNNLLVNSNLYDEAADTAYYLEKAYSLSSSATQTVNLAGPLVSITPPSGYDSAKLSINEGMPASKYYATQGISATVLYSLEKNGTSYTLSKLFSNLAKNERLSFDKNFSPRNSAQSFQNSANASVVNSDYYDNKDNYLYEVSSGRDRSLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE17</accession>
    <name>A0A398CE17_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D3H35_27330</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00675">
        <property type="protein sequence ID" value="RIE00675"/>
        <property type="gene ID" value="D3H35_27330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="15">
        <location>
            <begin position="126"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="417"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="478"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="126"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RIE00675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="695" mass="77729" checksum="6940F924C74C87AC" modified="2018-12-05" version="1">MQSIMIVEDEEALSRVLAAYVRKAGFDCRICRDGNEAVESFDAAQPSLVLLDVLLPGRNGWEVLRHIRSKSACPVIMLTAMSDVGDRIAGLNEGADDYIPKPFEPDEVVARIHAVLRRPPRSLVSSEQVVFGSFRIDLKSRTVFLNGASLSVTPRDLALLMFLAEHPNQIFNREQLIEKVWGIDYDGSDRAVDLAIKRLRKQLLHWPPEEGEIRTLRGTGISSMRTSPIRRRTLLSRWTFRYVLTLFIGLLTIGLASILWIRQETVHDRKQSLREFSQVASQYVTDGKGSIAVPKDFYEWIDRTQRLYQLPGQFSLTVFDRGDAPVFIKKAPLIAAGSSTPNIDSKPVLTDRIQTARTGGHYVLIAPVMSNHSPIGSIVIAYSYSDLANVNQNYVLIVSLLLCAGLLGWTIIYFLSWNLRKPIVQLSEALNKMEAGDYKVTVPDRVKEKEIHELLVSFQTMAARLGTLEELRTELLAGVTHELKTPVASIHGLIRAVRDQVVTDREAEEFLDISLEQTRRLQNMVTDLLDFNSFASGAISVRQDSIDLGKLLSEIAYQWELLYQEEGVEVAVDIPERACMAVGDASRIQQIAVNLLNNSRQAFQGRGSIVIALSEHSEKFCEISIRDDGPGIPEAEQAHIFERYYRGESKKLSIGGLGLGLTYSRMLAIAMKGELNLKISSPKGTAFQLLLPKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE69</accession>
    <name>A0A398CE69_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00930">
        <property type="protein sequence ID" value="RIE00930"/>
        <property type="gene ID" value="D3H35_25520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="266" mass="29287" checksum="3B0D760675802B01" modified="2018-12-05" version="1">MKVPTTFDEFVDAAAKLKAEGYTPIAVSGKEMWQLVRYLSFIPLRLTHTEFIDKLKTGDEKFTGEIGMKAANLLSTLGKGGYFQKGFSSMDYTQTLNFFLGGNAVIHYNGSWELAQFKDKYDSGEIGYFFIPEVAGAENNGPNTSITAGLAYAFNKETFDAETKRFFKFVVEHYNQAAFDVGGYLSPMNGDLPSNVFKLAKDFSLDLEAVAKGGVSWDDKLDPASNEVVGSTANELALGLITPEEFAEKVDKAIGRNAPSFFKDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEJ8</accession>
    <name>A0A398CEJ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_21665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01050">
        <property type="protein sequence ID" value="RIE01050"/>
        <property type="gene ID" value="D3H35_21665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="131" mass="14572" checksum="C7890425DE39A281" modified="2018-12-05" version="1">MDQKRLLIVDDQVGIRILLLEVFATEGYETFQAANGKTALDIVRLHSPDLVLLDMKIPGMDGLEILKKIKEINRSIKVIMMTAYGELDMIKEATDLGALMHFTKPFDIDELRSAVNAQLDEGSSSRYASGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF65</accession>
    <name>A0A398CF65_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_13685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01836">
        <property type="protein sequence ID" value="RIE01836"/>
        <property type="gene ID" value="D3H35_13685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="19"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="209" mass="22130" checksum="3064FE5C258E964E" modified="2018-12-05" version="1">MELFFRYVGENWRDLLVFAWQHVAMVAVGLLLALAVGIPLGVLASRSRPLARVILALANILQVFPTLALLVLLMVVFGLGTTTVVIGLFLYSLLPVIRNTYVGLTQVSPTLMEAARGVGMSSLQAMATVQLPLALPFILTGIRIAVVVAIGVATIAPLVGGDGLGREIYSGINMNNPARLYAGAVPAALLALFADLVLERLQKSAKIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFU8</accession>
    <name>A0A398CFU8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02066">
        <property type="protein sequence ID" value="RIE02066"/>
        <property type="gene ID" value="D3H35_14985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="118" mass="13385" checksum="6A23A6933AA4A4A1" modified="2018-12-05" version="1">MQQELIAETLETMNDYVPKLTEASEKIAHCIQEHDGSWADMLIAFLEGVAWFATAVEGIQRLDQEVLANVRMDGLAPLVDQLREALEHQDFVSLCDLLQYEMKPLLQSYEIALQGVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG51</accession>
    <name>A0A398CG51_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_12885</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01703">
        <property type="protein sequence ID" value="RIE01703"/>
        <property type="gene ID" value="D3H35_12885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="124"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="124"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="227" mass="26811" checksum="2556E26AF46118C6" modified="2018-12-05" version="1">MTTVLVVDDEEHIRELVRLYLEDEGMEIVEKPNGEEAWDYYTNHAVDLIVLDVMMPRMDGWELCRRLREAGDKPVLMITAKGEPMDRIKGFQVGTDDYLVKPFEPMELVLRVRALLKRYRISISQTIKLGNVTLDKTSCQIRYKETGKEESIPLKEFELLFMLATQPGKLFTRDTLIQNIWGYEYEGNERTVDTHVKRLRDRFNAYEQDFRIVTFRGVGYRLEVYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGA2</accession>
    <name>A0A398CGA2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_24335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01485">
        <property type="protein sequence ID" value="RIE01485"/>
        <property type="gene ID" value="D3H35_24335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="119" mass="11270" checksum="81835A1317E9477A" modified="2018-12-05" version="1">MRSRAQPVGRGTILSAGSVIPSASVGCGTILSAGSVIERASVGRGTILSAGSVIPSASVGRGTILSAGSVIPSASVGRGTILSAGSVIPSASVGRGTILSAGSAVESATSGTRYHSFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGF4</accession>
    <name>A0A398CGF4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LTA synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_21515</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the LTA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01032">
        <property type="protein sequence ID" value="RIE01032"/>
        <property type="gene ID" value="D3H35_21515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012160">
        <property type="entry name" value="LtaS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005091">
        <property type="entry name" value="Mmb_sulf_HI1246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="9">
        <location>
            <begin position="261"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE01032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="638" mass="72907" checksum="AD818B15418A3364" modified="2018-12-05" version="1">MQLLDGSEWKKRILQIVRIPLDVVEYGCFLFFIMLKLYLFDKYLGLVFTSNRMIVITFGSIMVVSFWTLLLPRFSRWVALWILNLVLSAIIFSDLVYYRYFSDFITIPVLQQAGQVGALGGSIENLIAWKDIVFFLDILITIPLFFVRRWFRRWPVGMWKRIPLTVLAAAIAYGAVYYPITDYTSKNGKTLFLNNWWNMSIFNVTGLLGFHAYDIKRYMDENVFSSNKVTAEQEASIKAWFDDHQKKLAAGSPSTGAAKGKNVIVIQLESFQNFVIGKSVNGQEITPNLNKLREEMMYYSNFYTQVGQGRTSDAEFLTNNSLYPLPSGSVYVRYPQHKYDSLPRLLKEQGYASYAFHAFEKSFWNRQAMYSGNYGLDKFYGMEDLKPGEIVGWALGDKQFFDQGIDAMKAGKQPFYSFMVALSSHHPYTNIPAKYKTIDVTPYKGNILGDYLYAVHYVDYAVGELVSRLKQEGLWDDTILVMYGDHDNGIKPDEDIAKFIGETYDDLTLDQIKNEVPLFLHVPGVDAKGEMQQTAGMIDLEPTILNLLGIDTSGLYLMGNDMMTMQNHLVVFRYGSFTDGKVYFKASKDGDFNKGVCYDLGTRAPVDLEPCRAGAQEASKQLGNSDKLIYNDLIREFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGS8</accession>
    <name>A0A398CGS8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_22420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01162">
        <property type="protein sequence ID" value="RIE01162"/>
        <property type="gene ID" value="D3H35_22420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="347" mass="38874" checksum="FEA7873621B1A4DB" modified="2018-12-05" version="1">MGKVTIKDVARRANVSVTTVSNVLNNSGRTSPDTIRKVRQVIEEMEFSPSASARNLRDKKSHLIAVVVPFLEKGRLQDNPFYWHLVLGVEEGARNHRLHVILLGVDEEESFSFVQERHLDGLIVVGTYEQSPIFKKILSLDVPCVFMDSYLSDPNLYQIYLDDEVGGYLGTKHLISLGHRRIALLTGKILEGGVSHMRWLGYCRAMEEAGLPYDPDLIREEPVSTIGGYQAAQYITDARKQITAVFVFSDVGAMGLIKGLHELGVQVPRDVSVVGFDDLFYTDYMLPSLTTVKQDIAERGNIAVQLLLDQISEELRYDSRKVVLPVSLKVRQSTAPVSPHHDENRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHJ2</accession>
    <name>A0A398CHJ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02686">
        <property type="protein sequence ID" value="RIE02686"/>
        <property type="gene ID" value="D3H35_18680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="206" mass="23021" checksum="17B7C0B44647D05C" modified="2018-12-05" version="1">MSRIIDISMTIEESMQVWKGYEHKKPKITNVQNHDQGKPHESRLDMDVHCGTHVDAPLHMLAGGATIETVTLEQLVGPARVLDLTHVVDHITKEDLLPFAIQRGERILFKTSSSLREDFDLNFPFLREDGAAYLAEIGPILVGTDALGIERAQAEYPTHRSLMRKDIIIVEGLRLKHVEPGNYNLVIAPLKLTGIDAAPARAFLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHL1</accession>
    <name>A0A398CHL1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spore gernimation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_28825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00418">
        <property type="protein sequence ID" value="RIE00418"/>
        <property type="gene ID" value="D3H35_28825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004761">
        <property type="entry name" value="Spore_GerAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34975">
        <property type="entry name" value="PTHR34975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03845">
        <property type="entry name" value="Spore_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00912">
        <property type="entry name" value="2A0309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="401" mass="45413" checksum="FED5B43A408B24B5" modified="2018-12-05" version="1">MTSLISSLKMRQSTSWKRSKSLLNEDFKKGGSMMQKRYTVSSWQMAALFLAYITGSAIVWIPAPLTGAAKNAAWISLWLAFGLGTLVLACILYLHRRYPDLTFVEYSELTLGRIATTIIAIPFLGMLLLMLSNITIGISQFFNSTMMRETPSYVFHLLILFTAAITVRAGIEVMARMFMLLLIALFIFVFSVLLLNLSSYRPELLTPVFEQGFKQTFFGIYQTWGFPYGEIILFSTVLPFIRRDRQHLGKLMFSALLINAISLSLSILCTIMALGPMAATVKFSLFELARLVEVADIIERIESVIGMTLIAASYMKATIVLFIFNATLSRLLRLQDEKILIFPTAFLTFLLTMTMYRNELEFNENVTAEWPLIITFFGVVPNLIIILVTVLNDWRAKIHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHQ1</accession>
    <name>A0A398CHQ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA phosphorothioation system sulfurtransferase DndC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dndC</name>
        <name evidence="2" type="ORF">D3H35_24580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01532">
        <property type="protein sequence ID" value="RIE01532"/>
        <property type="gene ID" value="D3H35_24580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017598">
        <property type="entry name" value="SulphurTrfase_DndC_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03183">
        <property type="entry name" value="DNA_S_dndC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="1">
        <location>
            <begin position="30"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="494" mass="57307" checksum="7C898FC9F21AAEEE" modified="2018-12-05" version="1">MSTGKLTREIIDNITAQIQRLYLEDTIPWVVGYSGGKDSSATLQLVWYAISKLPVESRHKTIHVISTDTLVESPVMSMWVILSHEKIKAAADEQQMPIVPHRLTPEIKDSFWVNLIGKGYPAPRITFRWCTSRLKIQPSNIFITNVVATHGEAIVVLGTRKAESANRASNMSFYENKRMRDGLSPNASLPNSLIFTPIEDWSDDNVWTFLMQYPNPWGFSNKELLTMYRGATADNDCPLVVDSSTPSCGNSRFGCWVCTLVSEDKSMKAMIQNDSEKSWMTPMLELRNELGKTDSSGKINDRDKRDFRKMHGNILLHNGQAVHGPYTKVWREYWLTRLLEVEIEVQQKGPEEFRKIKLISDDELREIRRIWVLNKHEFDDSLPRIYEKVTGNSYNYLNDIYRKPLGHDEWNLLKEICEGDELFFQLQTSLLDIEQQNYGYSVRKGLLDQLQNEIKKAFYTDEEDALEYKKQRENQKIELEKQLDFDHLLLSSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI10</accession>
    <name>A0A398CI10_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="2">3.1.3.89</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02896">
        <property type="protein sequence ID" value="RIE02896"/>
        <property type="gene ID" value="D3H35_19970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="25"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="198" mass="22830" checksum="703B89DE840AEE45" modified="2018-12-05" version="1">MAYHFLAYLYRMQYIERWSLMRNTSQENVAEHSYRVALLTHVLCSIARNVYKKDIDPDRAAGYALFHDATEVITGDIPTPVKHHNPRILANFREIEAIAADRLLSTVPGELQAAYEPLLKQQSDDPELIRYVKAADLLDAYLKCVSEMSAGNREFATARRQTEQKLNKLDMPEVEWLLTHLAPSFEKTIDEISEDEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI38</accession>
    <name>A0A398CI38_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_22885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01672">
        <property type="protein sequence ID" value="RIE01672"/>
        <property type="gene ID" value="D3H35_22885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="15"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="110"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="177" mass="20927" checksum="4C5626EB4A7E970A" modified="2018-12-05" version="1">MTEGMDKRAIFDELMMTYGKDVWNYAYFMTKRRDLADDIVQDVFLKVYGHMDIFHGGTSVKSWLLTITRNTALDYLKTAWIRRVQLFPDRFRTETHLSAENEWFGNEEKRRIWKLVLELPRKQREVLLLATHYQMPMKEISDLLGLSEGTVKSRLYRARQAVGKQLADGVSERSERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIC1</accession>
    <name>A0A398CIC1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D3H35_15255</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02115">
        <property type="protein sequence ID" value="RIE02115"/>
        <property type="gene ID" value="D3H35_15255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003097">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX_ECD" evidence="12">
        <location>
            <begin position="59"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="11">
        <location>
            <begin position="207"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR003097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE02115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="304" mass="33744" checksum="BD96BF87B00B8C1F" modified="2018-12-05" version="1">MIFNSVVRHLREGGKNVARNGWMSFASMSSIGVSLFILGVFLLLAINVNKLADQIEQQVQIRVYLKLDTEQAKIDEIERQIKRIPEVKSVTFVSKEEGLERLRKNLGDNGSALQGYEDDKNPLPDGFDVEVFSPQKIDFAAKQITALNGKDPEQSIWDVKYGEETVKKLFKITNAVRNIGLVIVLGLAVMAMFLISTTIKMTILARRREISIMKMVGATNSFIRWPFFIEGVLIGIIGSVITVALLLYGYARIVSTSKVDMGLMMIELSSVNEVAWTVGGTIVGIGILLGVWGSVISVRKYLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CID2</accession>
    <name>A0A398CID2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_13480</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. EmrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01802">
        <property type="protein sequence ID" value="RIE01802"/>
        <property type="gene ID" value="D3H35_13480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="11"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE01802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="515" mass="53591" checksum="D708D6E7667F55F9" modified="2018-12-05" version="1">MKNSNNRRWWVLGALALCLLTVGLDLTVLNLALPTLATELHATNGQLQWFADSYNLVLAASLLPAGLLGDRYGRKKMLLLALLLFGAASAACAFAGSAEGLIAGRAVLGLGAAFLMPLSMSIIPVLFTEEERPKAIGIWTMANALGIPLGPIVGGWLLNHYWWGSVFLINIPIIVIALIAVSVLLPESKSATRPKVDFIGVLASSLGLVGVTYGVIEAGERGWDDSMTLVSIIAGAAVLVGFILWERRARHPLIDLSLFRSSGFTWGSILATLVSFAMFGLLFVTPQFFQAVEGADSFGTGLRLLPIMGGLLIGAKVSERLKSRVGTGVTITLGFALLAIGLAVGANTGIDSGYGFVAAWISVIGLGLGFALPAAMDAAMGALSAERSGIGSALIMALRQVGGTIGVAMLGTVLSHGYRDKLKVDELQLPADVAEAAQRSVSAGVAAAHGIESTALLHSVRSAFVHGMDVMLWVCGGVAALGIVLTLVFLPQRAQGRRQAGSDPTTLGSEQGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CII5</accession>
    <name>A0A398CII5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00658">
        <property type="protein sequence ID" value="RIE00658"/>
        <property type="gene ID" value="D3H35_27225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="210" mass="22959" checksum="925AD52D0EE1149A" modified="2018-12-05" version="1">MYPTTVDSYTYVTFRALVDAIVPATPALAVFGADQTIGAVQLTVHEYMIWEMNNSLTLVLGYYPEVIPLAAPTAGLMNAGAIQLVASGQAKYAGPNSVPFASLSPEDRIRTLALLENLHVDLGTLPPPYRNDGGLVKFVVDFLNRQTMFGNYSEWPAYGTTRLATPTERKLEYFPIGWKQAGYPGVSKGYRAFRGNVLTIVREGGESFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIM9</accession>
    <name>A0A398CIM9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02593">
        <property type="protein sequence ID" value="RIE02593"/>
        <property type="gene ID" value="D3H35_18085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011748">
        <property type="entry name" value="Unchr_phage_tail-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02242">
        <property type="entry name" value="tail_TIGR02242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="710" mass="78917" checksum="C11484A34E0E2DA4" modified="2018-12-05" version="1">MEDGSTYFSVNRSEHWGRRGVARNLEDTDGMTVRKGEKYGILDTLQLETLEGIGEVSGFCVGPLGRLVLLSEDGDLWTYDRKSRHHERLFVTGHGLFGGTAQLAVTGDLLFVADASPDGVGEPTIAAYDMANGQMKWQRSGGMLDGVPFYPLAAASDDNYVYVLSPRAELEECEPDANGLVPLALIRLTLSGGMDAVFTDDRFAAYLPESSGDWRGIVFLAVSPDGGIHAFDSRGRVLFVFGLEGRLLTRMVLPPLSFAGLGVDSNRQMYLGDSRIIGEESEDDRFILHFGADGELIGRVAGFRGKTDGLLIDGSDRMYIWNAENRTITVLELQPQTLGWEGIGAPEGIWLSSAFDSAEAETVWHKFTLDADIPDGTQIRVSYFSSDSDKRVIGHSVRSVNEWISGKDISFDEKLAGLAPYWSEPVINPADALFFEAQGRYLWLKIEWIGSERTAPTLRRLRVYFPRDTLLSHLPSVYREESGSDFLERFLSLFGTLFDDMEEKIEGMALQFDRERVNGSQLRWLASWLGIACDEHWSDEWVRRLIRARSRALPLPGNEAGDRNADRDAYRHSAYHRRAIPIQSDAGACRAQMADRSFVRGRSSHVHAAPACGESRFRQGTRAAEIVGRGPYPGVHGSPDDVASTLDVSRFTYLSRRQHAADRAISIHDIRRSEHAERHADRGHGYGPANGRAHEAGTGFRVGIRRRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ94</accession>
    <name>A0A398CJ94_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage portal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01299">
        <property type="protein sequence ID" value="RIE01299"/>
        <property type="gene ID" value="D3H35_23230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014986">
        <property type="entry name" value="XkdN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038559">
        <property type="entry name" value="XkdN-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08890">
        <property type="entry name" value="Phage_TAC_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="140" mass="15916" checksum="1B27CAEA0FD78350" modified="2018-12-05" version="1">MSDLSVFYAQNVAVEEVEDFIVSERFKDKAGKPIPWKLRSMTEEENEECRKAATRKVKGKYGQQTVETNSDDYLAKLVVSSVTFPNLKNADLQKSYGVMGAESLLRKMLRPGEYSSIVQKVQELNGFDKDLNDLIEEVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJI0</accession>
    <name>A0A398CJI0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1835 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02292">
        <property type="protein sequence ID" value="RIE02292"/>
        <property type="gene ID" value="D3H35_16340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="318" mass="35343" checksum="7AC6E3D39042B58A" modified="2018-12-05" version="1">MLERARRETAKRMDKLLHILNGDVALRALGEAGIRGERLVWREIYTAGPLCADLLDDAARSTRAAWLEEAYGIPGADYSLGCERQQKQAIEAVEAGRTLAIWLDPDLFDQAIWMAVSSLLVPYCWKAFIVPLPYGPCDAARMEESWQRKSEISATELEAGARAWEAYCSLSPERIEHWLQADGELLPETADALRFHLLRYPGEDGLGIVERLTLRALSGDERNGLPLAELFRSVSEQAPLFGMGDLQYWRIVERLATGPSALLRLESGGTKVYGLPKLGAPPDYSAKLEPFGREVLEGTRKAEKGMAEVHTFTGSRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJV2</accession>
    <name>A0A398CJV2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="2">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">raiA</name>
        <name evidence="2" type="synonym">hpf</name>
        <name evidence="5" type="ORF">D3H35_24185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01459">
        <property type="protein sequence ID" value="RIE01459"/>
        <property type="gene ID" value="D3H35_24185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="4">
        <location>
            <begin position="123"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="181" mass="20713" checksum="0CE3609F53B81A7A" modified="2018-12-05" version="1">MKTIVHGTNLQPTEALRYYTEQRMARLESYRLEGAEAHVQMTVVGHKGLHKAEITLHGHEATFRAEEVTEDMYASVDGSVSKLERAVLKFRQRRKDLHRRPAEHAISAPQPPEGWEDAPDGEPFPVIRVKHVEAKPESVQEALLQMNILDHSFRLYTNDETNRVEVVYRRKDGGYGLITTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJX0</accession>
    <name>A0A398CJX0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_18120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02600">
        <property type="protein sequence ID" value="RIE02600"/>
        <property type="gene ID" value="D3H35_18120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="4">
        <location>
            <begin position="900"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1034" mass="112737" checksum="67717DF68534FC95" modified="2018-12-05" version="1">MAAMPCKKERTRLMNMDTWSRRIGIRTEDRRKLWLMAPVFLICGVAEALNYNGFMTLFNLRFGSEFLPYVYAAEAVILPLEAWFMSWLAGKLSKPSLMRAMYYIMTGVVAINAAALLVMRATGEDWRFYYPVLFLTSSFVVRQQTILLWSLAVDVCPTQQAKRLMPIFIAAATMGGVIAGLLTQVVNSWYGPDIVYAIGPVLLAAAVFNYRKAIARYLVPLTLRAAAGGPNAGSAEDGGSSALDYFRRTLRSPFLLGVLGMMTIMPSLYFLMEYVFLNTSHAAYPNEADFGRMFGVVTTVLFALAFLLQLVSGRLMAWLGASGMLTAIAGVYVVSFAAALFFLDSPAAVAAVSGGYMLTYLLLYYTAEPSYQLFYKTLPLAQRDGFRYVAQGISSCGGILLGAGLQLLHNGFGLGFAALAAVGAAGAAALLALSWFVRQLYMRELVKSIQVLGLAERELAESFREFARNSKTMGTVLAMLRSPTSGEEAKEIALDIIGRTKDVRYLPELLPLIDDANDRIKIAALKALNLAGADLHAMARVASLLEDPEPDVRTEAVRKLAGMKHMPSQAFFFLRMKLLDSHPGVVAEAVKAMYSLESAQSYEACFEVIEKILKEGGEPAVYVCRVVAELRLERFSPEVAKLLDDPSPSVRVAATACLGSLQATQVLSTLLERLRTADQELYRVTEQALSDMGSKAVAALKASLPNAAPKVWKASVAALSKLLPDDDVRGWLAEQGTLKLAENDEAMRLPAAFRQLGRTDLAELAELRVRDLRETVHGGIWAMLERLTDEQVVAAIRRAVDDQDEEIRGGGLEVLAEGVGERRLSQRLAATLQAEESVAIVLSDQEAEEAAHKAATSADDWWREMAAELNRSKTGGIAVLEEQGMLGRLNKVVFLKKVAFFADLSLEELGLIASVATEEKFSDGDLLLKRGEKNASLYVIVEGNVELTSVSAAGWEGTIGVVGPGEVCGANSALDESPSAVTAQAFFGDVRVLGLQRDEVTRLVRLYPEIGIGLLRASLARIRLLEEMIMRIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKF3</accession>
    <name>A0A398CKF3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spore protease YyaC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yyaC</name>
        <name evidence="1" type="ORF">D3H35_18295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02632">
        <property type="protein sequence ID" value="RIE02632"/>
        <property type="gene ID" value="D3H35_18295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009665">
        <property type="entry name" value="DUF1256"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06866">
        <property type="entry name" value="DUF1256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02841">
        <property type="entry name" value="spore_YyaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="171" mass="18159" checksum="EEB7EE3614A6086B" modified="2018-12-05" version="1">MNDTQRRHSERVNADGVASFISRISAAHKLSDLTFLCIGTDRSSGDCLGPLVGTMLEERGVTNVIGTLKEPCDADKLPSVAAALPLGRPVVAIDACLGRTETIGLYVVAEGPLEPAKSVGKRLPSVGAYSIAAIVNSYGPKPYASLQSTSLYRVMNMAHDITDAIIRHLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKL2</accession>
    <name>A0A398CKL2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03846">
        <property type="protein sequence ID" value="RIE03846"/>
        <property type="gene ID" value="D3H35_09855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="187" mass="19327" checksum="6519CA26919C0E43" modified="2018-12-05" version="1">MHDVAIIGAGPAGASAALFTAKAGKSTLLIDSDQSMTKRAWLLNHYGVEEISGPDLVEIGKKQAAKFGAEIVADKATKLIAGDGFVTIETEKGSFEATHVIIATGVFADLAEASDIRTKPGTEPRIKTVVDATPEGKTSLDNVWAAGTAAGVSVHTIITAGDGAKVAINVISELNGTRYVDHDVLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKQ8</accession>
    <name>A0A398CKQ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_29980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00261">
        <property type="protein sequence ID" value="RIE00261"/>
        <property type="gene ID" value="D3H35_29980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="196"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="303" mass="35311" checksum="EAC170D5F7362EEE" modified="2018-12-05" version="1">MRDEKREAGCLFHFDNHLSKDESTFGSIELYQIGELCCESGYEVEPHFQYCYEISYIVSGSGYFYIDDECVRVGEGDIFFNSVGHIHRIRTGSSQPLRYVYMGFMFNDLADEEFAPIHTFFRSASYYHSKDTHNLMLPFYRNIDEFYSQKPYSNIMIKNYLEEIIVLSYRAFTEKAGSSTRYSPQKSPNSVGYTVYSVIRFIENHLFELGSIKSIAEKLGYSYTYLSHTFKNKTGMTLQRYISLKKIEKAMEMLNYGDISINQIATKLGYETLQSFSKAFSRIMGYPPSLYKSKRQEEALPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKS1</accession>
    <name>A0A398CKS1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_20445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02975">
        <property type="protein sequence ID" value="RIE02975"/>
        <property type="gene ID" value="D3H35_20445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="224" mass="27407" checksum="7E0B3E99473859E8" modified="2018-12-05" version="1">MHFPLEEGYLIPLLPTRTHFPLEEGYLIPLLRARTHFPLEEWYLIPLLRARTHFQLEEWYLVPLLRARTHFQLEEWYLVPLLRARTHFPLEEGYLVPLLRARTHFPLEEGYLIPLLRARTHFPLEEWYLIPLLRARTHFPLEEWYLIPLLRARTHFPLEEGYLIPLLRARTHFPLEEWYLISLLRARTHFPLEEWYLVPLLRARTHFPLEEWYPVPLLPAHHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLD7</accession>
    <name>A0A398CLD7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_29030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00451">
        <property type="protein sequence ID" value="RIE00451"/>
        <property type="gene ID" value="D3H35_29030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="344" mass="36274" checksum="9ED97A99C4B346C3" modified="2018-12-05" version="1">MTTLSLTAPEKRKRRRNILVLTIVGALIVLAFLISMNTGYIRLSPAEVIRTLFGMGTHNQSLILYDFRLPRIVISILIGAGLAVSGCVMQGVSRNALADPGILGINAGAGLTIMLFISFYPSTAAAPVFLLPVLALIGAGLTAALIYALAYKRHEGLLPTRLLLTGIAVAAAISAATIVLTLKLSPEKYQFVANWMAGSIWGTNWKFVGALFPWIAILLPFVFYKARAMNALNLGESMATGLGVRVEKERLALLAAAVGLAGSCVAVSGGIGFVGLIGPHLARRLVGSKHQILLPASALLGSLLVIVSDTVGRSILQPHEIPTGIVVAVIGAPYFLYLLVNTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLG3</accession>
    <name>A0A398CLG3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_28280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000055">
        <property type="protein sequence ID" value="RIE00481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00481">
        <property type="protein sequence ID" value="RIE00481"/>
        <property type="gene ID" value="D3H35_28280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="969"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2013"/>
            <end position="2088"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="1004"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="2048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="2323" mass="262007" checksum="AAF5E5FA3D6D28AA" modified="2018-12-05" version="1">MKSSKGKIQDVYPLTPLQQGMFFHNLADKSSTAYFHQTCSTIGNPFDPVLFENSVNILIERYDIFRTIFIHEENEILQVVLRERPIQIYFEDISKWDAKEQFAYLEQYKQKDKAQGFDLTKGPLMRFALFYRGTEGYSMIWSHHHILMDGWCLPVVSKELFVIYQSLKEKKSLGFTAAIPYSRYIQWLERQDQKSASKYWENYIEGYAHSAQVPTLLNQNIEKFELEELQFSINEDLSGKLNQLANLHQVTVNTCMQALWGILLQKYNGIDDVMFGAIVSGRPSEIAGIEQMIGLFINTIPVRIQSRPGMSFSDLVKQVQLSSLSSAQYDYYPLYEIQANSSLKQGLVNHVMVFENYPIGEAIEQSSGQSIGFAISNVETFEQTNYDFTILIVPGNEIRIKFSYNAARIDRGMVARIREHLQEVIGQVVETPHVGIDQLEIVTEEEKRQLLHAFNDTKASYPENQTIHGLFEEQVKKTPDHTAVVLESESLTYAELNGRANQLARVLRGKGVGADRIVGILAERSLEMIVGILGILKAGGAYLPIDPDYPAERIGYMLEDSGADILLTQKRLEAKTMGFAGEVLHVDDERLYALDDTNLEHTGSSKDLAYVIYTSGSTGKPKGAMITHQGLVNYVSWANTVYMQEDRLDSALFSSISFDLTVTSLYLPLITGNKVVVYHGENQASVIRRIIEEDKVGLLKLTPSHLKLLETDVHLSSSTSMKRLIVGGEDFSHALAQSIYEKYEGKVEIYNEYGPTETVVGCTVYLFDAGSKGYTSVPIGVPASNVQIYILNSYMQEVPIGVAGEMYISGDGVSRGYLNQPELTAEKFVANPFAPGERMYRTGDLARWLPDGNIEYLGRIDEQVKIRGHRIELGEVESALRSHESVKEATVIARKDEEGSAYLCAYFVTNGNLGASELRKHLLKMLPQYMIPSFFVRVEQMPLTPNGKLDRKALPSPEGTLERGTVYEAPRNALEETLANIWQGVLGVSAIGIADNFFELGGHSLKATTLVSRIHKELNVQVPLREVFQSPTIKELAQAIRGMEAHAYASIEPAPLREYYPVSSAQKRMYILSQLQGADESYNMPGAVMMEGKVDRERFERAFRQLIARHEALRTSFEWVEGEPAQRIHLEVDFEISYKKAEEDGLRQIAEFIRAFDLGQAPLLRVGLLELEPERQVLLYDMHHIISDGVSMDILVREFVGLYGGNTLPAPRLQYKDYAVWQQAFMQSEAMKRQEAYWLETFSGELPVLEMPTDYPRPAVQSFKGDQIQFVLDGELSAGLNRIAAETGTTLYMVLLAGYSVLLSKYTGQEDIVVGTPIAGRPHADVENIIGMFVNTLAMRSRPAGEKTFTAYLQEVKEVALQAYEHQEYPFEELVEKLNVRRDLSRNPIFDTMFSLQNMSEEETEIEEMRFSPYGFEHSASKFDMSLTAVETGREIGLSLSYCTAIYTKETAERLGRHYVALLRDISSQTEKQLKAIELLSAEEKRQLLHAFNDTKATYPANQTIHGLFEEQVKKTPDHTAVVLESESLTYAELNGRANQLARVLRGKGVGADRIVGILAERSLEMIVGILGILKAGGAYLPIDPDYPAERIGYMLEDSGADILLTQKRLEAQTMGFAGEVLHVDDERLYAGDNTDLDYTGSSKDLAYVIYTSGSTGKPKGVMIEHINYSGLACAWNQAYKLNSFEVRLLQTASFSFDVFAGDVARSLINGGYMVICPDQKRLDFRELYSLLKEHRINIFESTPSLIIPFMEYIHEKELDIGELKILILGSDVCPSEQFIKLLNRYASSFRILNSYGVTEACVDSCFYESTENGISGRIHVPIGRPLPSITMYVVDKERQLQPIGVPGELCISGAGLARGYLNKPELTAEKFVANPFAPGERMYRTGDLARWLPDGNIEYLGRIDEQVKVRGHRIELGEVESALRSHESVKEATVIARKDEEGSAYLCAYFVANGNLGAAELRKRLSEMLPQYMIPSFFVRVEQMPLTPNGKLDRKALPSPEGTLERGTVYEAPRNALEETLANIWQGVLGVSAIGIADNFFELGGHSLKATTLVSRIHKELNVQVPLREVFQSPTIKELAQAIRGMEAHAYASIEPAPLREYYPVSSAQKRMYILSQLQGADESYNMPGAVMMEGKVDRERFERAFRQLIARHEALRTSFEWVEGEPAQRIHPEVDFEISYKKAEEDGLRQIAEFIRAFDLGQAPLLRVGLLELEPERHVLLYDMHHIISDGVSMDILVREFVGLYGDQTLPAPRLQYKDYAVWQQAFMQSEAMKRQETYWLETFSGNCRYWRCRRIIRDRRFKASKGIKSNLCWTGSCRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLH9</accession>
    <name>A0A398CLH9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar FliJ protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">fliJ</name>
        <name evidence="12" type="ORF">D3H35_11385</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03285">
        <property type="protein sequence ID" value="RIE03285"/>
        <property type="gene ID" value="D3H35_11385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012823">
        <property type="entry name" value="Flagell_FliJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02050">
        <property type="entry name" value="FliJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02473">
        <property type="entry name" value="flagell_FliJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE03285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="148" mass="17110" checksum="B132E41B4892F93D" modified="2018-12-05" version="1">MRFRYSMQKIVDLKGSEKSMAEWEYAASLGRLRAEEERLEQLLNERESVESRLVAASSEPIPLSELLTLQQYIDVLNERIRRQRNGVETAADQAGECRNRLKDRMVDEKVWLNAREKALVRFRTEWLAKEQNELDEIAITRAAAAASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLJ7</accession>
    <name>A0A398CLJ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000053">
        <property type="protein sequence ID" value="RIE00501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00501">
        <property type="protein sequence ID" value="RIE00501"/>
        <property type="gene ID" value="D3H35_28065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="69" mass="7641" checksum="407AB3958AC80FB8" modified="2018-12-05" version="1">MAPAVIPASPRQFRGSDRPESKVLKRKAEKKPSEPVKPAEKTAPEPAKERKIRKELLNRQAAKGTSHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLL0</accession>
    <name>A0A398CLL0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Peptide chain release factor 2</fullName>
            <shortName evidence="6">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">prfB</name>
        <name evidence="9" type="ORF">D3H35_15175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02099">
        <property type="protein sequence ID" value="RIE02099"/>
        <property type="gene ID" value="D3H35_15175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0488">Methylation</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="8">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="6">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="372" mass="42190" checksum="B7F74ECA4E14F2C1" modified="2018-12-05" version="1">MSVLDVTFKQDLRETAKRLQPLRGSLDLDLKLEQIANFEEKMSAPDFWNDNEKAQGVISELNGIKSVVDQYLKLENECRDLEDMIEILEDESDEEMAADWSDSVTALKAAVDSFELQLLLSEPYDKNNAILELHPGAGGTESQDWGQMLYRMYTRWAEKRGFKVELLDFLPGDEAGIKSVTIMVKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVSCDVVPEITDDVQIDIRSEDLRVDTYRSSGAGGQHVNKTESAIRITHIPTGIVCACQTERSQIQNRDRAMKMLASKLYELKIQEQKNELASIRGEQMEIAWGSQIRSYVFHPYSMVKDHRTQVETGNVGAVMDGDIDPFIDGYLRSQIKQEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLM2</accession>
    <name>A0A398CLM2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">QacE family quaternary ammonium compound efflux SMR transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_15280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02119">
        <property type="protein sequence ID" value="RIE02119"/>
        <property type="gene ID" value="D3H35_15280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="104" mass="11036" checksum="9795749E5AB6BF9F" modified="2018-12-05" version="1">MAWVALVFAGLFEVVGVLGINRWKERRDAIGITLLVGGFALSFVLLTIAMNSLSMGTAYAIWTGIGTIGGTAVGMAFFGESRKPVRLFFLGLVVVSAIGLKLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLU4</accession>
    <name>A0A398CLU4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Efflux RND transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02189">
        <property type="protein sequence ID" value="RIE02189"/>
        <property type="gene ID" value="D3H35_15725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="552"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="875"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="901"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="927"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="973"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1042" mass="111533" checksum="DBE3D96FCDD7ED41" modified="2018-12-05" version="1">MRSIIGFSLKNKFALWMITLIVIVAGLYSGLNMKQESLPNLTFPYLSVTTVYPGAAPDSVVEQVTSPLEKKLKNVEGVKNVTSTSMENVSSIALEFDFGQDMDKALSDIREATSGIALPSGVQAPEISKFSINSFPVISLSASGEGSLKELADLTKTVSEEVQPVLEGIPGVASVQIAGQYVQQVTLSFDKAKMAELGLSEDTVKGIVQASAVKAPLGLFTLENSEKTIVVDGRVTTIDDLKRLAIPAIPAAASGAGSAAPQPDELSPGMTMADGIPTVALGEIADIRMTGKEESISRTNGAVSIGIQIVKSNDANTVDVVNAVKKEADKLGEQYKDLKLSVLMDQGKPIEESVSTMLNKALFGALFAIAVILLFLRNIRTTLISVVSIPLSLIIAVLLLQQFDITLNIMTLGAMTVAIGRVVDDSIVVIENIYRRLALTGEKLKGVDLFREATREMFLPIMSSTIVTIAVFLPLGLVSGMVGQLFLPFALTIVFSLLASLLVAITVVPMLAHQMFKRGLKAGAKNHDHDEKPGYLARKYRGFLRSALNHKIITLVIAFALLGGSLALVGQIGASFLPEEEDKYTLITYSPEPGDRIEDVEKRALEAEKYLLKEPDITQLQYSIGGKNPLSPGPSKSGLFFLQFKSDTKNFADKKEAILGELHKVVPEGEWSEMDMGGGIGGSGFSLSVYGDSLEQIKPVVDQVVDLMNQDKAFEKVDTSLSKTYEQYTIVADQAKLSKYGLTAGQIAMALMPAREQPVLTTVKEDSKTYNVYVQADTAEYGTINDVIDTKLQSPLGVEVPVRDVTKVEKGESPNSIARENGKMVVTVSAEITEKDVAKVSSNLQKKVDGLEKPASVQVKFGGVTEQINETFTQLGLAMLAAIAIVYLVLVLTFGGGLAPFAIMFALPFAVIGGLVALWITGETLSVSALMGALMLIGIVVTNAIVLIDRVIHKEREGLTTREALLEAAGTRLRPILMTALATIGALLPLALGYEGAGIISKGLGVTVIGGLISSTLLTLLIVPIVYEILMKLRRKPKTLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLZ1</accession>
    <name>A0A398CLZ1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_10210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03663">
        <property type="protein sequence ID" value="RIE03663"/>
        <property type="gene ID" value="D3H35_10210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="111"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="246"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="460" mass="52644" checksum="78225816A3A47374" modified="2018-12-05" version="1">MVAWRTRYTPILAEFVRSGGNDAYAETVDLRRELKDVPTKDIVEHHDETVRFLLSYAEPEDRMTLVHRSLLFITDILFAIRMPEVAVAREQPEADRLRIAALNSVPLEESAPNKFETVLQHMDSGIALFDSAGNLRFLNVQMSKLLQVPRRSLIGCTLRQLFFHPHLKSHTRKMFLRMFKEMVLYRRFHGEFQNVHGKFLLVSISRIDELDGDYLISVKDVSEYKQIEQTAFQNDKLAMLGKIAAAIAHEIRNPLTSIRGFIQLLSPYLKEIGKQDYARIILSEIDRANDIIYEFLNSSKPSAPMKQTVLVGLLIKETILLLESEAHMKGCELHCEIFDPYVTIGIDVKQIKQVLLNIMKNAMEAIEETGDGRRGRIDISARREGRYALISIRDNGKGMERTTLNRLFDPFFTTKDDGTGLGLSVSYRIINNHGGIIHVDSVPNEGTEFMIYLPYTDIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM08</accession>
    <name>A0A398CM08_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_12535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03475">
        <property type="protein sequence ID" value="RIE03475"/>
        <property type="gene ID" value="D3H35_12535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005085">
        <property type="entry name" value="CBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM_fam20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03423">
        <property type="entry name" value="CBM_25"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01066">
        <property type="entry name" value="CBM_25"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="112"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="3">
        <location>
            <begin position="291"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="398" mass="41472" checksum="ACBBAA5614934D6D" modified="2018-12-05" version="1">MSAASGAITVTTNASTGNVVTIYYKQGYTTPYIHYKLNGTWTSLPGVAIPAAEVAGYNKITINIGTATQLEACFNNGSGAWDSNNGANYFFPAGTSTYNAGTIVSGAPDTEPPTAPTNLSSNSKSDTTVSLSWTASTDNVGVTGYEIYRGSTLIGTSTTTSYTATGLTGNTAYTFTVKAKDAKNNVSSASNAVTVTTDLTSGNTATIYYKRGFATPYIHYQPDPGSWTTTPGVAMTNSEFAGYSKITIQLGTASGLRVSFNDGNGNWDNNGGTNYYFYAGTSTFVNGTITGGLPQADSLTIVVTAPSNTPSNADLYLASSLNGWSTNDSAYKLTKNANGTYSITLSIASGTSFDFKVTKGSWAGVEANSSGTDIANRTFTTSGGAQTLNITVQRWKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM79</accession>
    <name>A0A398CM79_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_10985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03555">
        <property type="protein sequence ID" value="RIE03555"/>
        <property type="gene ID" value="D3H35_10985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07477">
        <property type="entry name" value="Peptidases_S8_Subtilisin_subset"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034202">
        <property type="entry name" value="Subtilisin_Carlsberg-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017387161" evidence="6">
        <location>
            <begin position="29"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="630"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="716"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="798"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1287" mass="134139" checksum="125E7710D43F9723" modified="2018-12-05" version="1">MKGLIRFLCLITALLLIISTVHPSLTSAESAKPNGFIIKLKNNANADAFISKRKLQGKKPKKTDSLNIISVDLSYSDYKELLKDSEIAFVESDAPVFAESRGKGEKRHPFIDNMKKSDQNVPWGIHSIGADLSNSKNIAGKNTKIAILDTGISAHPDLKVVGGISFVPSVASYLDDNGHGTHVAGIVAAKDNRIGVLGAAPEADIYSVKVLDKDGAGTYGQVIQGIEWAIQNKMDVISMSFGGDPYSEALHMAVKAATDNGIVVVAAAGNGGYGEETETYPARFEETISVGAVTKSHRLASFSSMGSEIDLVAPGQEIVSTSKDGDYVVMSGTSMAAPHVTGAVAALLSKNKKMSVEQLKKTLYSSATPLGSANQYGHGLVNLAKALGIVRSAIPPVEEPVVPSLPIEEPPVVEQPQTGFNINAIDDKLLALSNELLALKEEAAREGKRELAKRIEDDYQAFLLKNKELHILPIELSSIRKEDVVTKFANENVYFKQKELDFSKLEEAMKEAASSYAQLLPGFTAVSDQSDVGISAYDIVGNNQHIYPGQSATVSLKVSSAKPSVTIGVMNPSDTKIDGTIFYNVAANAAVSYTWYSSSSTPTGLYKIKYYYDSVITPDYFYIYVDPLPAPSAPGGLSSSATSSSLTLYWSGVSGATSYDVSLNGTYLANVTGTSYTFSSLSSGTGYSLGVRAKNASGSSSYSTISATTLSSAPGAPSGLSASSTTSSITLSWSPVSGAASYSLYRNGSLVTTTTSTSYTYSGLAGGTSYSVGVSTNNASGSSAVSSMTVSTQSGSGAPAAPSGLSASSTSNNITLSWLAVSGATSYTLQLNGTTVTTTASTSYTFSGLAANTTYTVGVAAVNGSGSSLFSTSSVATKAVSMPNLTLNSSVDVDLASGAYQAYAFTPSSTGTYKIFTGPYGGVGTSNDTVLELYSNSSLTSSITSNDDSNGTTFSEINWNLTGGTTYYVKLRGYGSTAVHARLSAVVAPPAPITMSLNVGYDVDSASGTYKVYKFTPSSSGQYKLFTGYFGGTSSGGSNDTLLYVYSDANLTNQLAYNDDSNGSTFSQIVMSMSAGVSYYVKIAGYGSGAVHARLTANAVTAAYAILAGNTPTDVDLAAGVSQTYQFTPTVSGPYLLTTGPYGGAATGANDTTLTLYSDAALASQIAFDDDSNGSGFSRLSATLSAGVTYYLKLAPYSSSIAVHARLLAVNDHGNDFGSAYPISLGSSTTASINYAGDVDFFRFQPASNGVYSIDTTGGTDTVVEVYDQKQILLGYSDDYLGPILLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM92</accession>
    <name>A0A398CM92_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding transcriptional accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00987">
        <property type="protein sequence ID" value="RIE00987"/>
        <property type="gene ID" value="D3H35_25600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05685">
        <property type="entry name" value="S1_Tex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044146">
        <property type="entry name" value="S1_Tex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="656"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="727" mass="80692" checksum="CFF0FA69743EA5AE" modified="2018-12-05" version="1">MADTTTQANAAEKTERMIRQIAGELGIGYNQVRTVAGLLDEGNTIPFIARYRKEMTGELDENQLRDIEERRNYLKGLEDRKAEVIRLIDEQGKLTPELSDSISKAAKLQEVEDLYRPYRQKRKTRASVARERGLEPLSEWLMSQPKQGDMRAEAAKYVDADKGVASPEEAIQGAMDIIAENVADDANIRKWVRKFTWDNGLLVSKAKNAEAESVYEMYYQYSEPVKRLPPHRVLAINRGEREELLSVSMDVPVNRITDELQRRIIRYPSIARDTLVAVTEDCYKRLIAPSIERELRGELTEKAEEHAIGIFSENLRNLLLQPPVKGRVVLGVDPAYRTGCKLAVVDDTGKLMEVAVSYPTPPHNKKAEAEALFRRLISQYGVGLIVVGNGTASRETEQFVVSVIKGLPELGLQYLIVNEAGASVYSASKLAQEEFPDLDVAERSAVSIARRLQDPLAELVKIEPKAIGVGQYQHDVAQKRLDESLSGVVESAVNHVGVDVNTASSALLSYVSGINATLARNIVKAREENGKFGDRKQLQKVPRLGAKTYEQCVGFLRISDGKNPLDSTPIHPESYDVVDKLFRELELPLAVIGSDTLASKLRSASVEELAAKLSVGVPTLRDIIESLLRPGRDPRDELPPPIFHTDVLDIEDLKPGMELQGTVRNVVDFGAFVDIGIKNDGLVHISQLSNKFVKHPTEAVAVGDTVTVWVLGVELKKSRVSLTMRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM96</accession>
    <name>A0A398CM96_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DinB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03382">
        <property type="protein sequence ID" value="RIE03382"/>
        <property type="gene ID" value="D3H35_11940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="159" mass="18284" checksum="E98C3DB5E86672FA" modified="2018-12-05" version="1">MKDQRSEAHQIIENYTNNWFGYEFDDSTWNKPIAEGKASVAEIIGHLLNWDNYLIETVIPTVKNGGGMEFPDFDTFNKAGYAYVKNKPRSLILQEFNSAREKLSEMLLNSLEFIDKPTTSNGVSVCPHTGRPYSLIYIIEEFIEHDEHHKSQINAVITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMM6</accession>
    <name>A0A398CMM6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_10490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03715">
        <property type="protein sequence ID" value="RIE03715"/>
        <property type="gene ID" value="D3H35_10490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="154"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="311" mass="34873" checksum="D27E5A7FC599B562" modified="2018-12-05" version="1">MIQILLYTNMAMLLLAYVSAISTMKAGDVTGRSIGVIAVNLFLPIASLYLAQRSINRKQFVPSLLFSMLLIFFTLTNMIQMVVGLIILLMFFVLSTRAYFKGEIRAEKAEQRIETGESGDEGESEGESAEEQVKALPSSDQTAPVSRPRHDPIVEIREAGEEEAGTIHALMMGAFEEYRAAVPPSSALSETVESIREAIRNGSESAAILYEDDKAAAMVRFRMEEDSIYFFRLSVLPARRRRGYAKKLIQWIEQRGVGQGKLYSRCKVRQSVQNNMVLYQDRGYEIIDQELVVRPEGSVKALKMEKKLGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMS2</accession>
    <name>A0A398CMS2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03540">
        <property type="protein sequence ID" value="RIE03540"/>
        <property type="gene ID" value="D3H35_10855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011230">
        <property type="entry name" value="Pesterase_At2g46"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030250">
        <property type="entry name" value="Ptase_At2g46880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="12"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="323" mass="36091" checksum="E8F6477EE4B3067E" modified="2018-12-05" version="1">MSRLRFNEDGTFKIVQFTDIHWQNGEPADWRSLALMKEIAANEKPDLVVFTGDVIHSELTADPKAAFADAVSVVTGEGGVPWAFVFGNHDAEEGVSRNELMELARKLPGCMAEQGPVDVHGVGNYRLSVHRSAAPEEVGASLYLFDSGSYAPQEIGGSAWIHRSQIDWYVRESSRLKAGNRGNVVRSLAFFHIPLPEFNEVWDFRACCGHNFEGVGCPKINSGLFHAFWERGDVKGVFVGHDHVNDYWGTLHGIRLCYGKATGYNGYGSEGLPRGARIIRLHEDERPFDTWLRLDNGQVVYEQPVHIPAIQDLILQSNKRLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN90</accession>
    <name>A0A398CN90_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02709">
        <property type="protein sequence ID" value="RIE02709"/>
        <property type="gene ID" value="D3H35_18840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="115" mass="12023" checksum="507B48217DE8AAEB" modified="2018-12-05" version="1">MAGQRITLLGALAVTFELTITSGGTSRTIDDFGDSFVVRSFPVGNGPVPDSIGADIRVLRQGRRGGARLCSGPLFQGPVGVYHAIVSRTGNSTYAAAIRKRSFLTWAAIGGAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNB2</accession>
    <name>A0A398CNB2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="5 10">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">nrdE</name>
        <name evidence="12" type="ORF">D3H35_05105</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="5 10"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04846">
        <property type="protein sequence ID" value="RIE04846"/>
        <property type="gene ID" value="D3H35_05105"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026459">
        <property type="entry name" value="RNR_1b_NrdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013554">
        <property type="entry name" value="RNR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08343">
        <property type="entry name" value="RNR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04170">
        <property type="entry name" value="RNR_1b_NrdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIBORED_LARGE" evidence="11">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE04846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="694" mass="78573" checksum="3DFA2DAA44DFE086" modified="2018-12-05" version="1">MRHIELNNLLMQRDSEGFFQLDKDREAVEAFMADVYRKSRTFGSTAEKVRYMIDENFYENVYEFYSESDVEAIYAITHGYDFKFQSYMAASKFYTDYAVKTDDKKLFLEHYADRVAIVALHLAKGDVTAARALASSMMEQRLQPATPTFLNAGKSRRGEMVSCFLLEMDDALNSINHVLGTCMQLSKIGGGVAVNLSKLRGRGEPIKGVEGAAKGIMPVLKLMEDAFSYADQMGQRKGSGAGYYNIFGWDIMEFLDSKKINADEKTRIKTLSIGLIVPNVFYQLAERNEPLNVFAPYSVYKAYGVHMDDMDMDDMYDKLMADDRVKKKVVMSARDMLVKIATIQLESGYPYIMNRTNANREHALKELGTIKMSNLCTEIFQLQETSDIGDYGQPDVIRRDISCNLASLNIANVMELKKIRESVHEGIVGLTSVSDMTTVANAPGVAKANSELHSVGLGAMNLHGFFAKNKIAFESDEAKDFVRTFFMMMNFHSLEKSMEIARDRGVTFQGFERSEYAKGTYFDRYTTTDYRPTTARAKELFAGIDVPSPMDWASLKLDVQSHGLYHAYRLAIAPTQSISYVQNATSSVMPIVEPIETRTYANSTTYYPMPFLSRDNFFFYKSAYQMNQFKVIDLIAEIVPHIDQGISTVLHVNSDVTTRDLARYYIYAAKKGLKSLYYTRTNRLSVEECISCAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNF8</accession>
    <name>A0A398CNF8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aamy domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03852">
        <property type="protein sequence ID" value="RIE03852"/>
        <property type="gene ID" value="D3H35_09885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="115"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="161" mass="18526" checksum="26383B204DBFA334" modified="2018-12-05" version="1">MGVYHAESESAMLSWWMSDMFPAVSTMTLIKEEEQLRRESVVYCPCELERGESISIGTFYMSRMKGSRLDALRKAADAFRIYVRSDSQALAGQKTLKICELHIGEKIGRKTFDDYDQIAKKLSYLKSLGFNAIQIMPSFPFPSYSVYDYFNLDKTYGSERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNI8</accession>
    <name>A0A398CNI8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_09610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03800">
        <property type="protein sequence ID" value="RIE03800"/>
        <property type="gene ID" value="D3H35_09610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="430" mass="47098" checksum="9D6333E1E0C015A8" modified="2018-12-05" version="1">MKRLFMSSFVLNIAVMVLNIATGILMARWLGPYGRGEFAAATRWAGLLVGLSAVGLPGAIIYLGKQYRERQRELFGAYLLLGMGFGLLGLLIGEMLLPFLMGGQSKELLQYARIAMLCLPFAVLTDGLIGTLQSLNLFRKVMFLRLMSPIGSLAVIGGLAFAGRIDVPGLIWWNTVLWGLFTFLITLVWVYRTLRPKLSGLKDNVRQLFRNGVKIYGGSLVSIFGGNFDQLVLSLALSPYALGLYAVASSVGGILPSVVFGALNVFLWPKLMDLPREQRQRKVERIHALLFYGTSGATLIGAALLPFALPLLYGHEYEPAVWMGMLMLAAAPVRIGCTVLLNYLNTEGKFHTVSLSEAVSVGTGFAVMMALLSFAGEEAAAIGIVAATVVKWLFVWIASRKLGIRFGALFVVHWREDLHRLSSFRKTQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNN9</accession>
    <name>A0A398CNN9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01191">
        <property type="protein sequence ID" value="RIE01191"/>
        <property type="gene ID" value="D3H35_22600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="268" mass="30464" checksum="E12B471872B552C2" modified="2018-12-05" version="1">MTIDILERNNVKILGNGTKPIVFAHGFGCDQDMWRYIVPNFESDYRVILFDYVGSGKSQLDHYDANKYNDLQGYAQDVLEIMDALELRNAIFVGHSVSSMIGLLASNRDSKYFERIVMLGPSPRYINDLPDYYGGFNRNEIDELLTMMQMNFIGWASYLAPIAMQNSERQDLTDELEKSFCSRDPHIARQFAEVTFLSDCRGDLPFAPVPSLILQCSDDSIAPIEVGNYLHAHLKDSTLQLMNAKGHYPQLSHPEETTALIKNYLNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNT8</accession>
    <name>A0A398CNT8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_08585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04002">
        <property type="protein sequence ID" value="RIE04002"/>
        <property type="gene ID" value="D3H35_08585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="49"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="351" mass="40491" checksum="4145CE54D900B99A" modified="2018-12-05" version="1">MKAKELQLKKEVAPFEKNDIRSSVRQMANTLLPLAALWIAAYYSLSISFWLTLPLAIAASGFVIRTFIIFHDCCHQSFFKSKLANEIVGTITGVLTLVPYHQWKTTHSIHHATSSNLDKRGVGDIWIMTVEEFAAASFWRRLAYRIYRNPLVMFGIGPAFIFLVDYRFNRKAARRRERINTYLTNVSLVALYALLIWAIGWQAFLLVQGPVFFFSGLAGVWLFYVQHQFEDSYFENEDEWSYVKAAVEGSSYYKLPKPLQWMTGNIGFHHVHHLSPRVPNYRLEAAHNATPPLQQATTINLRTSLKSLNFRLWDENNKKFVGFREFKLAYRKGRSDSQSNLAIPRPGLEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNU5</accession>
    <name>A0A398CNU5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Purine nucleoside phosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pgeF</name>
        <name evidence="10" type="ORF">D3H35_06565</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:24409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27642"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:27643"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27647"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:11853"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04273">
        <property type="protein sequence ID" value="RIE04273"/>
        <property type="gene ID" value="D3H35_06565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16833">
        <property type="entry name" value="YfiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003730">
        <property type="entry name" value="Cu_polyphenol_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038371">
        <property type="entry name" value="Cu_polyphenol_OxRdtase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30616">
        <property type="entry name" value="PTHR30616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02578">
        <property type="entry name" value="Cu-oxidase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00726">
        <property type="entry name" value="TIGR00726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="268" mass="29163" checksum="023033DEDD604766" modified="2018-12-05" version="1">MEPFQPADGSDLSPLLVLESWSGPDFEGVTAGFTTRHAANTALHVGDNPLDVVRSRLDVADSLGWDFSSWTCAEQVHGVRVHHVQSGDVGRGRESRESAIPEADALITNESNVLLAMYFADCVPLYFYDPTTGALGLAHAGWKGTVADIAAHTVRRLQETFGVEPAQLYAAIGPSIGECCYEVDEAVLSHIRPLAAEAGANDVLYGESGGRARIDLKQMNRHLMIKAGILPSRIEISKWCTGCRTDLFFSHRAEKGHTGRMMSWLGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNZ9</accession>
    <name>A0A398CNZ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01607">
        <property type="protein sequence ID" value="RIE01607"/>
        <property type="gene ID" value="D3H35_25015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="SSF50985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="73" mass="7845" checksum="A6C09FEAC7AE2AA7" modified="2018-12-05" version="1">MHRRRKCFFISAEVGWHRGRLGYNLNGETNVPVGLTGVAAIAAGDHHSLALKSDGTVVAWGAVPMVETMCPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP82</accession>
    <name>A0A398CP82_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_06110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04192">
        <property type="protein sequence ID" value="RIE04192"/>
        <property type="gene ID" value="D3H35_06110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="73" mass="8765" checksum="3354C18DBE132B12" modified="2018-12-05" version="1">MVYDIIMFGKRAVPLDNRAKKEGSRQRLNERVHELADDLEFRRRWKRVNSIELWSDAAIFRLNDGSKWYLNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPI4</accession>
    <name>A0A398CPI4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02618">
        <property type="protein sequence ID" value="RIE02618"/>
        <property type="gene ID" value="D3H35_18220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="134" mass="15628" checksum="26B9BC71CA89C6DF" modified="2018-12-05" version="1">MFLHGPLIKLESCPPIELDYLYGEADSMRLGKVLEEKRMQIVREALSGVKIAVLGRKYEIHPETIRNWVREYGDKVGPDQLPSTDEQIQELKRLQEIEEKYNLALKKLGEKELENEILHELLKKKNPAYLKNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPZ0</accession>
    <name>A0A398CPZ0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_03725</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 9">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="9"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04613">
        <property type="protein sequence ID" value="RIE04613"/>
        <property type="gene ID" value="D3H35_03725"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006236">
        <property type="entry name" value="PGDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045626">
        <property type="entry name" value="PGDH_ASB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19304">
        <property type="entry name" value="PGDH_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01327">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="7 9 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="457"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE04613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="530" mass="57008" checksum="A2E9995DB5F66958" modified="2018-12-05" version="1">MFKVLVSDPISDLGISLLVEANDITIDKKTGLSEDELVAIIGEYDALLVRSQTRVTERIMTAGTQLKVIGRAGVGVDNIDLDAATKRGIIVINAPDGNTITTCEHTFAMMMAVARHIPQAYLKTVGGVWDRKSFVGVELRNKVLGVLGMGRIGSEVAARAKAFGMEVYGYDPFLTEERAEKLGVRLASVEDIIRDADFITVHTPLTPETRHMIGKEQFGRIKKGVRIVNCARGGIIDENALVEAIDAGIVAGAAFDVFEEEPPAADHPFLKHPKIIVTPHLGASTIEAQENVAIDVSEQLLHILRNEPFKNAVNMPPVPADVLSKLEPYFTLGKKLGSFAAQIAEGPVKEIVVGYAGDLADVDTQPLTRYVVQGVLAHHLGSDQVNAVNAMHLAKTRGVNIVVTKSTASKGFTNQVSVTLRTDKEERFVAGTLLNGFGPRITQVDKFPVDVEPQGHLLLISHHDKPGIIGRVGTLLGGNDVNIATMQVGRKQVAGAAIMVLGVDKGVPKEVLTQLAALPDLNNAKEIHLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQC5</accession>
    <name>A0A398CQC5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02978">
        <property type="protein sequence ID" value="RIE02978"/>
        <property type="gene ID" value="D3H35_20460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="245" mass="27786" checksum="58A3F22268A7DA2C" modified="2018-12-05" version="1">MTGTKYLKLLGLILVVVISDILVFSPGFIGLEIGGSALATASGVTLLSASALVLLYGSYALLFKQPVVIPVKQIKTHEDYVEALSRYRQVKVLEDDIALALEQMDRMTKKKDTLFGVLSQRFDPTELSFKKFASVAQEVEKLFYLNVRSILNRLHVFDESEYKSVMRKNSASFSRELLQEKTNVYNEYLSFVKSSLGSNEEILLKLDKLLLEISRLDSFEPGDIENMPCMQEIDSLIKQTKYYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQU4</accession>
    <name>A0A398CQU4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiazole biosynthesis adenylyltransferase ThiF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03168">
        <property type="protein sequence ID" value="RIE03168"/>
        <property type="gene ID" value="D3H35_17290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="3"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="329" mass="36175" checksum="F17FB62ED7F84F5A" modified="2018-12-05" version="1">MLFAPIGEDGQRKLKSSAVCIVGMGALGTVLANHMVRAGVGLVRFVDRDYVEQSNLQRQMLYDEEDVHNGYPKAIAAEKKLRKINSDVRLEAIVADVTVHNIESLLQGMDLVLDGTDNFQTRFLLNDACFRMGIPFTYGGAVSSRGMSAILVPGSTPCLRCMIQSADANGQTCDTIGVISPVVDIVASYQAVEALKYLVDADGQRRNSLVTFDLWNNHYYEMKLAEPRNNCPCCQLKVYPALNTTEQDSAISLCGRGTVQMAGSGPLDLELWRQRLEPATVKVTVNAYLLRAELPDGERLVLFPDGRVFVQGTDDVVRAKTLYARYIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQY7</accession>
    <name>A0A398CQY7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heme-degrading monooxygenase</fullName>
            <ecNumber evidence="4">1.14.14.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Heme oxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Iron-regulated surface determinant</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Iron-responsive surface determinant</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">isdG</name>
        <name evidence="8" type="ORF">D3H35_16005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the biliverdin in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]</text>
            <dbReference type="Rhea" id="RHEA:21764"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57991"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.14.14.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the antibiotic biosynthesis monooxygenase family. Heme-degrading monooxygenase IsdG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.18" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02237">
        <property type="protein sequence ID" value="RIE02237"/>
        <property type="gene ID" value="D3H35_16005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042167">
        <property type="term" value="P:heme catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033212">
        <property type="term" value="P:iron import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01272">
        <property type="entry name" value="Heme_degrading_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023953">
        <property type="entry name" value="IsdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="19"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABM" evidence="7">
        <location>
            <begin position="284"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="389" mass="44089" checksum="AFA25F8CCD678943" modified="2018-12-05" version="1">MRRRSFFLNAVEKKEVDQVMAVEISELAYKQDHFQLHVANEKLPKGRITAIVGRNGSGKSTLLRMIAGLIRPESGAIHYDGEPGTAFSRKQFALKVSMLSQDKGHIPDLTVRELVALGRAPRQSSFRSRMSPEDERAVKWALSAVGIRHNEDRLFHTLSGGEQQKARIAMALAQEAQIILLDEPTTYLDLAFQLELMETLRRLNRSLGLTIVMVLHDLQQAAAYSDYLIAMENGRIAASGPPKSVIDQRFMLNVFGVAAQIDLKGSYPVIIPIPQPFKEETNMVIVTNVSQITKGNGEKLIERFNRVGKVEGMKGFLGLEVMLTENTKEYDEVTVSTRWESREDFQLWTRSEAFRESHSHREKPDYILSNKIVYYDVKVVRQPFAQVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR03</accession>
    <name>A0A398CR03_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02257">
        <property type="protein sequence ID" value="RIE02257"/>
        <property type="gene ID" value="D3H35_16115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="28"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="287" mass="31472" checksum="42A34DFBDC269F92" modified="2018-12-05" version="1">MKLGVSTYSFWQAMEKGEMDVVQALGHIAAMGGEHAEIVPLGFDLTANPELIAAIRGKAKEVGIELSNYAVDANFAGLGDEEYEAEIERVKREVDIAAALGVSLMRHDVARSDDRSIGRFLADLPRLVEACRRIADYAAPLGITTSVENHGYYVQASDRVQAIVGLVDRPNFRTTLDVGNFVCVDEDPVVAVRNNIAIASMVHAKDFYRRPAYENPGEGWFRSAGGAYLRGAIVGQGDLDIRSALRIVRESGYDGFLSIEFEGMEPCVQGTRIALDNVRRFWEEAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR18</accession>
    <name>A0A398CR18_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplF</name>
        <name evidence="7" type="ORF">D3H35_02315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05005">
        <property type="protein sequence ID" value="RIE05005"/>
        <property type="gene ID" value="D3H35_02315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="90"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="180" mass="19662" checksum="4C2B86E4F809A111" modified="2018-12-05" version="1">MSRIGRKPIQVPNGVNVNLDNNVITVKGPKGTLSRELHKDMKVTVEADVITVERPSENKLHRSLHGTTRSVVANMVSGVTDGFARNLELVGVGYRASKSGDKLVLNVGYSHPVEFVPQAGIEFEVPAQNRITIRGIDKELVGATAAKVRAVREPEPYKGKGIKYEGERIIRKEGKAGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRB0</accession>
    <name>A0A398CRB0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_04175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04690">
        <property type="protein sequence ID" value="RIE04690"/>
        <property type="gene ID" value="D3H35_04175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="3">
        <location>
            <begin position="4"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="2">
        <location>
            <begin position="186"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="290" mass="32434" checksum="A347BE9B740C5898" modified="2018-12-05" version="1">MFRKIGVVGAGTMGQSIAELLSSKGLDVYLVEKTPELLDQAMETLEASLDRQMERWAITGAEKKLLLNRIHKNVTMAALAECELVIETISEDLDSKIEVFAELDRLLPSDTIIASNTSTLSLTELAGATKHPERVIGVHFVYPAMKVDVVELIRGLQTSDDTFVKTKLFIEDILYKKGVMVYESPGFVTTRLICLLINEALHLMEEGVANPEDIDSAMRDGYQFGYGPLEMADRFGLDSVLAALDRMFREFGELKYRPSFLLKKKVRAGHLGVKTNIGFFKYNKDGERES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRC8</accession>
    <name>A0A398CRC8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="8">HTPA synthase</shortName>
            <ecNumber evidence="4 8">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dapA</name>
        <name evidence="10" type="ORF">D3H35_11675</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 8"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03338">
        <property type="protein sequence ID" value="RIE03338"/>
        <property type="gene ID" value="D3H35_11675"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="8">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="8">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="300" mass="32338" checksum="957117932919FD42" modified="2018-12-05" version="1">MSFGQLVTAMVTPLDDQLNINWEVTGELIDHLIDAQQSDSLVICGTTGESPTLTDEEKEKLFRFAVERAAGRCKIIAGTGSNDTAHSIHLTKLAEEAGVDGLLLVGPYYNKPNQEGLYRHFRAIAESTKLPVILYNVPGRSVVNISAETTLRLAQLPNVVATKECSSLEQMTEIIREAPEGFKLYSGEDTITLPVLAIGGHGVISVASHVIGATMKQMIEAYKSGKVAEAAAINNDIYPVLKGLFHCPHPVPNPVAVKYALSQRGYAVGGVRLPLVTASDEEADFIRRLLAKVAPSVLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRF7</accession>
    <name>A0A398CRF7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_11860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03368">
        <property type="protein sequence ID" value="RIE03368"/>
        <property type="gene ID" value="D3H35_11860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="227" mass="27042" checksum="B6D0A16CB584AFF9" modified="2018-12-05" version="1">MISFLMSMLFYQRSDKAFTVEEINQFELMFSEAHQNGGLVNFNSVFPKYRFIDYIIQQKNAVAHGSNNMGIESFETRRQTLYNGKLVDAIFASKDGIWPIFYAVFDRGKLVSNFRNGCIKTRSKKRYYFFSLTKQTLDRNPWTTGMIYFMLSETFELTSTSKIYFDEWVSKQEVKPMLRLCVCKEDFEYINKISTHKQTESLLTTWFFYKLRTSLLRYLRKNVARSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRK2</accession>
    <name>A0A398CRK2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03408">
        <property type="protein sequence ID" value="RIE03408"/>
        <property type="gene ID" value="D3H35_12125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016657">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02140">
        <property type="entry name" value="Frm2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033877">
        <property type="entry name" value="Frm2/Hbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035">
        <property type="entry name" value="PTHR43035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="199" mass="22547" checksum="EBEB9B56BAE86514" modified="2018-12-05" version="1">MAKEFWTAVRERRSLYALSKQSPISDARIQEIVEEAVKHTPSSFNSQSARLVLLLGEQHNKLWDITTEVLKGIVPANQFEPTQQKMDAFRGAYGTVLFFEDKSVIEGLQASFPSYQDKFPIWSHHTSAMHQFVVWTGLESEGLGASLQHYNPIIDEKVKAEWNLPASWSLEAQLPFGTPVAPAGEKQFKPLEERIKVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRT4</accession>
    <name>A0A398CRT4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1405 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04890">
        <property type="protein sequence ID" value="RIE04890"/>
        <property type="gene ID" value="D3H35_04060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009845">
        <property type="entry name" value="DUF1405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40042">
        <property type="entry name" value="PTHR40042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07187">
        <property type="entry name" value="DUF1405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="222" mass="25611" checksum="FB9985982460A74F" modified="2018-12-05" version="1">MKEPTEVSLRWYFSKHCLLHPVTLLLLLLIYVPGTIYGYIWYEDQLVKTWNHHPHWQIPFVPDSPTASLFFAIAVLWLWISPKPSKSGFVQSIRGIIEALGVVTSVKYGIWATVIIFWGQAQGDVLYWEHWMLIIGHTAMAVTALLYARFFFFNWISLAVAAAWTFLNDSIDYGYGIFPYLPSELDDDLVLVRNFTFILTGLSVLSGAWARFVLRRKSDNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSN7</accession>
    <name>A0A398CSN7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
            <shortName evidence="5">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">prfA</name>
        <name evidence="8" type="ORF">D3H35_14485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01974">
        <property type="protein sequence ID" value="RIE01974"/>
        <property type="gene ID" value="D3H35_14485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCRF" evidence="7">
        <location>
            <begin position="63"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="5">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="357" mass="40345" checksum="1144F7A445A82238" modified="2018-12-05" version="1">MLDRLQVLADRYDKLSELLCDPDVANDPSRLRSYAKEQSGLEEAYQAYQEYKEAIGQLQDAKAMLDEKLDDDMRDMVKMEIEELEPRIGELEERIRILLMPKDPNDGKDIIVEIRGAAGGEEANLFAADLYRMYAKFADSQGWRTELLEASVSDLGGFKEVIFQISGREAYRKMKYESGAHRVQRVPETESGGRIHTSTSTVVVMPEAEEVDIEIHDKDIRVDTFCSSGAGGQSVNTTKSAVRVTHVPTGIMATCQDGKSQNDNKAKALQVLRTRIMDVKRQEEEAKFAGERREKVGTGDRSERIRTYNYPQSRVTDHRIGLTLHRLDSVLNGDMEEIVNTLTTAEQAEMLERENMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSV5</accession>
    <name>A0A398CSV5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_06990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04339">
        <property type="protein sequence ID" value="RIE04339"/>
        <property type="gene ID" value="D3H35_06990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="243" mass="26253" checksum="B6FF4F45492E5E8E" modified="2018-12-05" version="1">MVSVHTCIEANRVTRKFGRQTVLDNISLTVRQGEIFGLLGPSGSGKTTLVKIITGLDVPDGGEVTLLGERMPKLSMLSRIGYMAQSDALYGELSAQENLAFFASLYGLRGAGLKRRMEETAELVKLTGDLKKPVHLYSGGMKRRLSLAVALMHEPEVLVLDEPTVGIDPVLRKSIWNELESLRRGGVTILMTTHVMDEAEKCDRLAMIRDGSVIASGSPIELKSSSGTSTMEDAFVAFGGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTE2</accession>
    <name>A0A398CTE2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04529">
        <property type="protein sequence ID" value="RIE04529"/>
        <property type="gene ID" value="D3H35_05390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="53"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="224" mass="25931" checksum="42741DE9CF04A0FC" modified="2018-12-05" version="1">MILKNQLLDNDFRKIPFIRMIVMGRTVPTIMRREGFLMYKRVIGPQDQSQFDSIWQEAWLEKGFELEPSNEESHRLLILDDETAVGTVEFKRYIPGYASIDQVAPFQASILLRESPDAVMEVDKVAILKAHRGKHIGKMLTAMTLFAEQEGIRYFVSLLDPVFYRALKVSFRIPIDCVSEDRPYYKGARVVPAILHVHDVYGNKERYPWLVPSHEFGQTEKVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU74</accession>
    <name>A0A398CU74_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02514">
        <property type="protein sequence ID" value="RIE02514"/>
        <property type="gene ID" value="D3H35_17645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="154" mass="18049" checksum="4D379DABD909ED16" modified="2018-12-05" version="1">MDLMESVKSRMNGRSDLRYQPFEANGYGCCVLYLEGSIDLEMLQSHVFRPLQRRANGVDKDRWRRSLFDDLNLMSTPYFVTDNEDDMIAAMLEGKVVLTVKDKAGRRYCRLRSNRSAPSRCRRTRRRFADPKTRSWRTSGRIYRLSGNGSRRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU85</accession>
    <name>A0A398CU85_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_17745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02534">
        <property type="protein sequence ID" value="RIE02534"/>
        <property type="gene ID" value="D3H35_17745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="307" mass="33677" checksum="A467916C95D3C4F8" modified="2018-12-05" version="1">MIQCEGLVKIYKAADLEVFALQGLDMNVEAGELMAIIGNSGSGKSTLLNMLGGLDRPTAGSLTVNGKNMLKMSERDLVSYKRESVGFVWQNNARNLIPYLTALENVELPILLQGRRKRMRALELLEAVGLTHRKNNKLHQLSGGEQQRVAIAIALANEPKLLLADEPTGSLDSRMADQVLDLFRELNRTIGITIVIVTHDPLLAKKVDRVVAIRDGKISSEMLRRKSYAEELEELERGIAAEEEDSHVEYAILDKAGRLQVPAAYLESIGVKDSNKVKLELADGKILLTSPGAPKKSVDPDNSEEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU95</accession>
    <name>A0A398CU95_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_06535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04268">
        <property type="protein sequence ID" value="RIE04268"/>
        <property type="gene ID" value="D3H35_06535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045197">
        <property type="entry name" value="NUP210-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019">
        <property type="entry name" value="PTHR23019"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017332938" evidence="6">
        <location>
            <begin position="30"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="7">
        <location>
            <begin position="167"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="8">
        <location>
            <begin position="377"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="8">
        <location>
            <begin position="464"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="8">
        <location>
            <begin position="548"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="8">
        <location>
            <begin position="632"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="8">
        <location>
            <begin position="717"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="8">
        <location>
            <begin position="801"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="8">
        <location>
            <begin position="886"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="968" mass="100269" checksum="79F2DF15D1F768DA" modified="2018-12-05" version="1">MNLMKKAKWMASIGFAAAFIALAGGTAYAANDTAGTLEELQSKVDTAMHERPATYSVDYSGSGLTSAAISSLIQEVFEADDYLHYSTKTYSFSASGTSGATTVKFNFTYWESKAQADYVKNTVQQTLNTILTEGMNDFQKQKAIHDWIELNLAYDTTKKQHSAYAGLTSPYKTVCQGYALLAFRMLTDAGIENRIVEGKAGGELHTWNLVKLDGKWYHFDTTWDDPLPDVTGRVIYDYYNLTDDQISQDHTWERADYPAANSEFDQTLTAKIADDPSNASIYQGIYDALGFEYSKAELTASNQAELSAFVQQAIQNQEEGIKIRYTNKAALAADVTAVMKGTSNITSYSYSYSSYTRTTSSTDIVLNLKFTYNIPIPVQSVALSKNALDLKIGGTGPLISSTLLATVAPANASTKSVTWSSSDTSVATVAGGVVKAIGPGTATITATTVDGGKTATATVTVKKGVTGVTLSAKSLTVKAGGPDQTLVANVLPVDASDKIVTWTSSNTSIATVDADGIVHAVAPGTATITATTKDGAKTSKTTVTVPINVSGVSLDKSDLTLAVGSKGVTVKATIAPLKAADKSIIWTSSDTSIATVSKTGLVSPVAEGSATVTAATYDGGFKATVNVKVIIAVTKVTLDKSKLTVKVGYPDEKLTASINPGDASDKDVTWTSSNTSVATVDADGNVHAIAPGTATVTATSKQDSKKFAKATVTVPVNVSGITLNTSSATLSVGKKTLALKSTIAPAKATVKTVKWTSSDASVASVSSTGIVTPLKEGSATITATTDDGSFTASAAITVIVAVDSVKVGTSAVTLTIGDSYSAQTVSINPGYATVTAVTYTSSNLAVVTVDADGRLEAVSPGTATITVKSVQDGSKTAKYTVKVLPKASGVKLSVTTLKIKSGGKAVVLKAVIAPTNTALKTVQWTSSDDSVATVDDKGAVTPVGAGTATITVTTDDGGFIATCTVTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV16</accession>
    <name>A0A398CV16_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03717">
        <property type="protein sequence ID" value="RIE03717"/>
        <property type="gene ID" value="D3H35_10500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="217" mass="25255" checksum="B4B8CCCEFE7D3728" modified="2018-12-05" version="1">MIKHVVFDFDGTIVDSLGAVVDIYNEIAGQYRFTKLDQDRYRALMNVPLRERIKALGVPMHRIFFIRNVARQFKQKYQTQLHLIRMIDGVLEAAERLKEQGYVLSILTSNSEANVREYLRNREISIFDHVYSANGLFGKHRTINQYRKQHRLSREELIYVGDETRDIQACRKSRVPIIAVTWGVEDRALLAAANPDYLIDRPQEIANVLFSETGEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV47</accession>
    <name>A0A398CV47_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cu_amine_oxidN1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_20020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02904">
        <property type="protein sequence ID" value="RIE02904"/>
        <property type="gene ID" value="D3H35_20020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017367805" description="Cu_amine_oxidN1 domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="2">
        <location>
            <begin position="52"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="463" mass="48596" checksum="EF38710CEEFABA6E" modified="2018-12-05" version="1">MSMKKTISSTVLAAALGVTVVGAVNAASAVNVQSTIYSVNGIEASIETISQNGKTLASVRDLGEALGADITFAGSIVTVTLNGHTVVLSKNSDNISVDGIAQKLTAPVTNVKYKNYIELDAYIKSLGGTVELDASGVASIETTGELLEDADRVDWLDVNRLIVSKDTEAGRVDYLLNVHTGKFEELLNNPNASELVVSPNGKKAAFTDNTGAVYVIDLATKASAQVSADTNIKPELVWSADSNSIYFLQGDKGSVIVKLDTADGKLTKVLEDKVDYKSNLNVSSNGNLFTYIVTKPGAVTAPSDKPVDADDVAIDTTGTEPQIYSFDATEKDGKPVKLTTNSEDKVFFQASDDGHFAYFVSVPTDGNSVLSSVGKSQALKVLLGDKDVLQSLIIGGKAYVLTSGPAGSNLISIVDTLTGESKLLYTVSDSVSEIAVSAGGLIAIVQDGKTYVNESGNWKQVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVI6</accession>
    <name>A0A398CVI6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03024">
        <property type="protein sequence ID" value="RIE03024"/>
        <property type="gene ID" value="D3H35_20730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="99" mass="10672" checksum="4A7FEE96529AA997" modified="2018-12-05" version="1">MYGSGPNGTGMYNTNGTYGTTGTGMYNTYSTNGTGVYNGKTNYGTNTYNPSAYRAYNTRTDGVYRAKATTGRSWGWLGLFGLIGLAGMFGGNRQRDPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVS4</accession>
    <name>A0A398CVS4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage IV sporulation protein A</fullName>
            <ecNumber evidence="1">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Coat morphogenetic protein SpoIVA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spoIVA</name>
        <name evidence="2" type="ORF">D3H35_03865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATPase. Has a role at an early stage in the morphogenesis of the spore coat.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04638">
        <property type="protein sequence ID" value="RIE04638"/>
        <property type="gene ID" value="D3H35_03865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014201">
        <property type="entry name" value="Spore_IV_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09547">
        <property type="entry name" value="Spore_IV_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007466">
        <property type="entry name" value="SpoIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02836">
        <property type="entry name" value="spore_IV_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="492" mass="54978" checksum="10F1978619703023" modified="2018-12-05" version="1">MEKVDIFKDIAERTGGDIYLGVVGAVRTGKSTFIKRFMETVVLPNIAHEADRIRAIDELPQSAAGRTIMTTEPKFVPNNAVQLKVAEGLEVNVRLVDCVGYTVEGAKGFEDEGGPRMITTPWFEEPIPFQEAAEIGTRKVIQEHSTLGVVVTTDGSIAEIPRSAYIEAEERVINELKEVGKPFVLIVNSARPKSEEAQTLRSELAAKYDIPVLTLSAATMGEEEVTGVLREVLYEFPVHEVNVNLPSWVMVLNENHWLRSAYENSVRETVKDIRRLRDVDRIVAQFTEYDFVARAGLSGMNMGQGVAEIDLFAPDELYDKILTEVVGTEIRGKDHLLQLMQDFAHAKREYDRFAEALEMVKTTGYGIAAPTLAEMVLDEPELIRQGSRFGVRLKATAPSIHMIRVDVESEFAPIIGTEKQSEELVRYLMQDFEKNPIKIWDSDIFGRSLHSIVREGIQGKIAMMPDNARYKLQETLGRIINEGSGGLIAIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW16</accession>
    <name>A0A398CW16_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04077">
        <property type="protein sequence ID" value="RIE04077"/>
        <property type="gene ID" value="D3H35_09030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="1">
        <location>
            <begin position="134"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="361" mass="41500" checksum="3A9A8446EF563F57" modified="2018-12-05" version="1">MLFCVYSSESGSGCRRTNTMGPSHADEGGSAMNIVFLNRLERVEGKTEERGQVYIGEDQGNWTAGWQPFDQQPDATEETWYEGVSWEELLASFRHGVAGKMVAGYRPLLDGMLEEKPFWEKPTLPQLLQCYADAQPESALAVKLKHWRKTKSQEEGRSAYLVATNKEIQLLAVFIPQTLDELGQIPGFGKIKIEKYGKQLIGMLLDESRPHSFPLQWVERAVEPETFRVWLFRLREDKYGRALVTVREKKALLSAIRDGQTLAELEKLLECSRRKLVERLEKLDEEGYDVTPIIDKELGEVPYDEWTQVQGAISKLGDRYLKPILREVYGEPAAGDQEVERRYEKLRMMRIRLRREGQKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWD5</accession>
    <name>A0A398CWD5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Insulinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_11645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03334">
        <property type="protein sequence ID" value="RIE03334"/>
        <property type="gene ID" value="D3H35_11645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="3">
        <location>
            <begin position="11"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="168"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="426" mass="47498" checksum="DB2B103E43784267" modified="2018-12-05" version="1">MNKYQLRNGLRVLIESIPTCRSVSFGIWVKTGSRNETPDDNGVSHFVEHMLFKGTKRHTAKDIADKFDGIGGNVNAFTSKEYTCYYAKVLDQHLPIAVDVLADMFFESELASAELAKEKNVILEEISMYDDTPDDTVHDLASRAAYGDHPLAYSILGTAERLNKMGSDDLREYMKKRYRIENTVVSIAGNVGEEVLELLEQHFGQFDVRGTDVELTPPVFRSGSLFHQKKTEQNHLCLTFPGCSIQEPNLYAMVLLNNTIGGGMSSRLFQEIREKRGLAYSVYSYHTSYADSGLFTVYAGTAPKQTKDVYELTMELLDDISAKGLSEAELFRGKEQLKGNLILSLESTSSRMNRLGKNELMLGRHYTLDEMLERIDRVTLDDVNGMMRTILGSSCAIALVGSQQKVLSGIGREFVVSNTVEAAAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWS7</accession>
    <name>A0A398CWS7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_10195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03661">
        <property type="protein sequence ID" value="RIE03661"/>
        <property type="gene ID" value="D3H35_10195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="582"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="625"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="701"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="729"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="761"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="793"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="852"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="7">
        <location>
            <begin position="8"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="879" mass="96155" checksum="C6355BDE03898749" modified="2018-12-05" version="1">MKLTEIEMFKGLSNLELSKLLGKMDKLSLAPGAVLFEQGDAGDSMYLIESGEVELFARADGTSHSLARLEEGGSLGEMALLTGETRSATAVASTDSVLYKIDRETFDWLVAEQPGISAYFIRLLSERLIRTNDSLQASKESKVLWIRQQLEQLPDEWVQFLVWCEKLPYISEKLALERFGYNLVSTTSKYPDLLHFLHVENRNENRETEGIRLKSEVRPVLSDYGVEKYGYDRKKTWLEEAAAFYESEGDWQGALALSVELKDFDAFLRAFDLLHSPLTSAEEARLARALKRCPADWLVSRYSVLERVVTSCLNDSRSSEFGLAVIESALGRSGSSYKGAELVALYEGASGFCRILNRKQQAMEYLRLAEEAAGSASKGTAVADTNDERHYSLAKRKLAANRTQFLAAQANRLAESNSWTGWLAVALAVGCILLFHFLPEPAGLSRGAMDFIGIGLAGVILWIVNIIPDYIVALGMAMLWVLFGIVKPESALSGFSSPTWLYMIFIMALSAVITKSGILYRLSLHALKRFPPHYRGQISGIVAGAIVLNPLIPSSSAKVSLGVPIARSLAESLGFKDNSRGAAGLGLTAMIFYGFTAPFVMTGSYTNVMAFGLATGHSTVSWLQWALYALPAFFVFAAVMLAVLGMMFKGVSTTKGISLKVLDEQLRLLGPLSSEERISIGTVVGCVLLMMLEPLHGIDSAWVMFAGFAVLVVSGVLDSRTLKSGIDWTFLLFLGVAFSFANAAGELGIADALSAFLGDHMGMFISSPMLFLAIVVLLSFAVTLVVRDDPAVILLVTALIPLADQAGIHPWIVVFVILLSTDPFFFSYQSPTYLTAYYSSEGKSFSHRQGRMVALGYALAVLAVTIVSVPYWKWLGLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWY2</accession>
    <name>A0A398CWY2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03711">
        <property type="protein sequence ID" value="RIE03711"/>
        <property type="gene ID" value="D3H35_10470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="121" mass="13755" checksum="94A341F600CC5D7B" modified="2018-12-05" version="1">MTTFGNRLKYARNGKKLTQTDVANKLGIDFTTISKYENNKSEPDNEILRELASLYEVSVGWLITGSTSGHEDTDPNRITVNGATELLSNEEGLFLLDNLEMYRLLKAKREKDRRKKEEAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXB1</accession>
    <name>A0A398CXB1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03851">
        <property type="protein sequence ID" value="RIE03851"/>
        <property type="gene ID" value="D3H35_09880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="175" mass="20549" checksum="0EB26A8985278BA4" modified="2018-12-05" version="1">MVLHGPLEKEPASWRMPPGEYEFDSPYLTDRTGWFSRHESGDYARTYTRSFDLANPELRRHISEAIAYYAGSVGIDGVRLDAQTWNFFPNWRPEGGRKPYESIYAGFRMMEEIRKEAKRHYPDLIFYTEGWALLRQSTTSFATTTIFIGYTRHYRLSGTNGECRRCSGTRHRKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXY3</accession>
    <name>A0A398CXY3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05398">
        <property type="protein sequence ID" value="RIE05398"/>
        <property type="gene ID" value="D3H35_00800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="447" mass="47932" checksum="E06E1951D18C27BF" modified="2018-12-05" version="1">MVNPLKIGRVWTGRGAMTAIVRTSAANLIIMVLSTATSIVTARLFGVTGKGEFSAILFWPGLLAGALSFGLPTSLIFNRKSHPAQGADYIRAGFLFQLPVSLLAGTAAWFCLPFWMGNYSDSIVRIAQWYTVATLPLLLAVGLLSALAQSMENFNLYNGLRVYVPLSNLLGLAALWACGVLSQGSAALVFFCTSLAVVCWSLLRLKRELTVGWFGRFADRAAIKSLFGYGGRVYGVELLGTLYAQCDKLIILALLAPREFGLYSVVYTLSRVFNIVQTAVSNVVFPKVTGLAPERIVATVCRAFRLSLLLMLVALVPGLLIGRFLLGLLFGQPFLEAGTAFGLLSLECIVGGGSWILASSFNALGRPGLVAMRQAIALALTVGLLFALAPAYGLNGIALAMLLGAFSRILITLAAMKIVFKAPISGVLFDKGDWRFLADRLKRATQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY02</accession>
    <name>A0A398CY02_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000006">
        <property type="protein sequence ID" value="RIE05418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05418">
        <property type="protein sequence ID" value="RIE05418"/>
        <property type="gene ID" value="D3H35_00585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="62" mass="6965" checksum="D45FFA30DB73E7A5" modified="2018-12-05" version="1">MDPRCSDENGRSRERIQLADARRQGGVTKLLHHALRKMREAGQTISMLHPFSVPFTANTGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYY0</accession>
    <name>A0A398CYY0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04441">
        <property type="protein sequence ID" value="RIE04441"/>
        <property type="gene ID" value="D3H35_07605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="87" mass="10231" checksum="345FC1BB01A80539" modified="2018-12-05" version="1">MKKRRSRKKDKIPFFIISLSPRLFLNYYMEKEQPKDSAGNEFERRRPVFPTDQYPETAAISRRRSPQANRPSARSIATKQKSAGKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ12</accession>
    <name>A0A398CZ12_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">M20/M25/M40 family metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_02855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05087">
        <property type="protein sequence ID" value="RIE05087"/>
        <property type="gene ID" value="D3H35_02855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="445" mass="48444" checksum="73F8EB4A8455A5AF" modified="2018-12-05" version="1">MNGNERLSASIRHWIASNRCRMTDLLSELIRYDTVNRVVDGTERECQLALHAKLLELGMEAELYSPEEVSGFREHPAYYPGKDYRDRPNVSAAWKGAGGGRSLLFSSHIDTAAVAPGWTTDPHAPYIEGNKLYGLGSYDMKGGLVASAMAVRCLMELGVTLRGDVRIESVVDEEFGGANGTVAGRARGDHADAVIIPEPTNLALYPATRGGALWRVTFQGTTGLSFNGETVRNPASDAARFIVYLEQHEKERARQSGPAPWYSDSKETLPIIVTRLEAGDLDSPLCDVGPVECHVDIWVECYPGIDEDGLREELLTGYERFCGGSCEQGLARPAFARMIRFLPGSSVDPDFPLLPILAREIEASTGRPAEVTGSPFACDAFVFNEYSPSKALILGPSGGNAHAPGEFVDLDSLDTLVEIYARAIINWCGLSSDDRILAVEQEERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ91</accession>
    <name>A0A398CZ91_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_02015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05167">
        <property type="protein sequence ID" value="RIE05167"/>
        <property type="gene ID" value="D3H35_02015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="393" mass="42611" checksum="2861236D35CAAC13" modified="2018-12-05" version="1">MSDQSRGPLSGLRVLEFGQIAAGPFAGQLFADLGADVVKVERPDGGDGMREWPPFFTNEEEEDEEAFSANFSSLNRNKRSIEVDFKSPEQVDRLRKLSAKADVIVENFRPGVLRKFGLDYETLAKENPKLVYASISGYGQKGPYSQKGAFDVTIQAISGLMSVTGEEGGAPVKSGVPVADFAAGLYAAFTVVAAVYEASRSGKGAYVDTSMLASALGISALQTSEYYGNSVAPKRLGSAHPRNAPYQGFEASDKPFVIAAGNDKLWREVADAIGQAELAGDPRFANQSLRARHQKELANLLQAEFSRRTSAEWLAEFDRRGVPCAPINDYEDILRDPAVAESGLLHKLPLPNGTATTTVGYPVKLSGFDFQVYRSPPLRGQHNGQLYEDWGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZJ6</accession>
    <name>A0A398CZJ6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2768 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04631">
        <property type="protein sequence ID" value="RIE04631"/>
        <property type="gene ID" value="D3H35_03825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020076">
        <property type="entry name" value="DUF2768"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10966">
        <property type="entry name" value="DUF2768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="59" mass="6630" checksum="F6732ECE14AB819E" modified="2018-12-05" version="1">MDPMEKMWVSFLGIGLMVIAAVIISFARLKTRGWVKLVLSSIAFVMLLFGFVYGMFAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZW9</accession>
    <name>A0A398CZW9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetyltransf_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000006">
        <property type="protein sequence ID" value="RIE05407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05407">
        <property type="protein sequence ID" value="RIE05407"/>
        <property type="gene ID" value="D3H35_00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041380">
        <property type="entry name" value="Acetyltransf_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17668">
        <property type="entry name" value="Acetyltransf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyltransf_17" evidence="1">
        <location>
            <begin position="26"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="129" mass="15163" checksum="446BCE0F03FEF60D" modified="2018-12-05" version="1">MLSKPGGPLYRNPDGIAEVICCMRRADRKMRIHEWVHTTETARAALWSFIGNHDSMIDQLVMMAPEDDDLPFLLPERAFKQELLPYFMSRIVDVERFIEPYSFAASEREDVLAIRVEDERADWNDGWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1P5</accession>
    <name>A0A398D1P5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000006">
        <property type="protein sequence ID" value="RIE05421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05421">
        <property type="protein sequence ID" value="RIE05421"/>
        <property type="gene ID" value="D3H35_00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="89" mass="9515" checksum="9D0262A10ABF218C" modified="2018-12-05" version="1">MTPLSSAIESWMEGALGVRAIMLSMIECRAPEDIRLGTSASSRWSSSWSNGSKSLPFIVRIREIAAVSPSFAKLGKASIGPKIAMRATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1V5</accession>
    <name>A0A398D1V5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-deoxy-7-phosphoheptulonate synthase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aroF</name>
        <name evidence="3" type="ORF">D3H35_00010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000001">
        <property type="protein sequence ID" value="RIE05481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05481">
        <property type="protein sequence ID" value="RIE05481"/>
        <property type="gene ID" value="D3H35_00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041071">
        <property type="entry name" value="DAHP_snth_FXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006268">
        <property type="entry name" value="DAHP_syn_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18152">
        <property type="entry name" value="DAHP_snth_FXD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01361">
        <property type="entry name" value="DAHP_synth_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_snth_FXD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="DAHP_synth_1" evidence="1">
        <location>
            <begin position="84"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="353" mass="38610" checksum="B4BC3BEA577607F3" modified="2018-12-05" version="1">MIVITSPHIEEERIAEIVRQIENSGVQAHVSRGTDRTVIGIIGKADPHLAEHIRSMKGVENVIKISKSYKLASREFHPDDTIIEVKGVKIGGNNLVVMGGPCAVETPEQIDEIARLVKAAGGQVLRGGAFKPRTGPYSFQGIGIEGLKWMKDAGDKYGLLTITEVMAPEFVDVCAEYADIMQVGTRNMQNFDLLRKLGTINNPVLLKRGMSATYDEWLNAAEYILAGGNPNVMLCERGIRTFETYTRNTFDLAAVPVVQQLSHLPVIADPSHATGRRELVETMTKASVAAGANGLIIEMHTDPDNSATGDGVQSLFPDQFANLLKELEQLAPLCGKKFDTAKEPAEAFREWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBL7</accession>
    <name>A0A398CBL7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_30120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000064">
        <property type="protein sequence ID" value="RIE00170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00170">
        <property type="protein sequence ID" value="RIE00170"/>
        <property type="gene ID" value="D3H35_30120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="134" mass="15232" checksum="DAB8938B72903D3C" modified="2018-12-05" version="1">MRSFCSQHIIGDSLRLKQILINLIGNAIKFTSKGEIFVKISVDEHIKNDYKIRFDIRDTGIGIPKDKLSQLFQAFSQVDSSTSRKYGGTGLGLAICTRLVELMNGGISVKAQKEKVRFQLYHQDRSREKQFGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBN8</accession>
    <name>A0A398CBN8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00190">
        <property type="protein sequence ID" value="RIE00190"/>
        <property type="gene ID" value="D3H35_29570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039650">
        <property type="entry name" value="HdrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498">
        <property type="entry name" value="PTHR43498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="434" mass="46636" checksum="00ED9E7F8CF5DAEB" modified="2018-12-05" version="1">MSEVQYKKSLAVKKHYDVIVAGSGPAGICAAVAAAREGATVALIERYGVLGGNLTMGHVGPVLGSVAPGGLRDELMGLLGVPDNDYLGVIGVAHDGEKAKRVITNFVRNAGVDIYLQSPICDVIMDENKLSGLVISGKKGMYALTAEITLDATGDGDIAFFSGAGFQVGRTSDGLMQPVTLEFTINGVDESRAIACIGEVDDVMLGDERFNDFTARCVREGLLPEVMTSVRLHRTVAPGERRVNTTQSNGIDATDVKDLIKAEVELRNQMNELMIFLRKYVPGYENSQISSSANTLGVRETRRFIGEYILTDDDLAEGRKFEDAIVHNANFIVDIHNPIGGGQAEGIPEEVQPYDIPYRCFIPVGVDNLILTGRCISGTHRAHASYRVMSICMAMGQGTGIAAALSVKDKTTPRLLNPSLVRSRLMDLGVQMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCV1</accession>
    <name>A0A398CCV1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Preprotein translocase subunit YajC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yajC</name>
        <name evidence="9" type="ORF">D3H35_27705</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00533">
        <property type="protein sequence ID" value="RIE00533"/>
        <property type="gene ID" value="D3H35_27705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01853">
        <property type="entry name" value="YAJCTRNLCASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE00533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="104" mass="11495" checksum="510691D8C5DAEADF" modified="2018-12-05" version="1">MWLAEGGGSSIWGMILPFVLMFAIFYFLLIRPQQRKSRERGSMLSALKKGDKVTTIGGLHGTIDTITDDTIVLKVNDVSKLTFDRSAINNVTARSTEVKSESES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDS6</accession>
    <name>A0A398CDS6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">(R)-citramalate synthase</fullName>
            <ecNumber evidence="4">2.3.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_28025</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + pyruvate = (3R)-citramalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19045"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30934"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.182"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from pyruvate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.182" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00585">
        <property type="protein sequence ID" value="RIE00585"/>
        <property type="gene ID" value="D3H35_28025"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043714">
        <property type="term" value="F:(R)-citramalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005675">
        <property type="entry name" value="Citramal_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43538">
        <property type="entry name" value="PTHR43538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00977">
        <property type="entry name" value="citramal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="10">
        <location>
            <begin position="5"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE00585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="537" mass="58392" checksum="E2AF8E43B955E9FB" modified="2018-12-05" version="1">MSTSLCIFDTTLRDGTQGEGISLTAEDKVKIALKLDALGVHYIEGGNPGSNSKDIEFFRRIRELNLRAKLTAFGSTRRKNIACEQDANLKHLTESGASAATLVGKTWDFHVHTALQTTLEENLAMIHESLAYVRSKGMEALFDAEHFFDGYKANPEYALAALAKAKEAGTEWIVLCDTNGGTLPSEIHEIVSRVRSVIDAPIGIHTHNDCEMAVANAIAAVSAGARQIQGTINGYGERCGNANLCSIIPTLQLKMGYDCVSDEQLTTLTSVARYVSEIANVILPVNQPYVGNAAFAHKGGIHVSAIMKDSKTYEHISPALVGNKQRVLVSELAGQSNILSKAQELGLDVGAEGLKSRNVIDRIKELEHQGYQFEGADASLELLLRDAYGDTVDIFTVETFKIIVEKTANGMVSEAIVKINIGGEQVYTVAEGNGPVNALDNALRKALSQFYPGIHDIHLTDYKVRVLNEKDATAAKVRVLVESTDFKDSWNTVGVSTNVIEASWEALVDSIRYALLGMVKRDVSPQAPRESYGWVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEG2</accession>
    <name>A0A398CEG2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00242">
        <property type="protein sequence ID" value="RIE00242"/>
        <property type="gene ID" value="D3H35_29860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="69" mass="7753" checksum="1830A12668B9F296" modified="2018-12-05" version="1">MFLAGNAAEEAASTFTNFDIFMVIFTVLIVVALVRLLLQRPRKNIFAIGFTTVSLLVFLIADWKMLSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEN5</accession>
    <name>A0A398CEN5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_29200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000058">
        <property type="protein sequence ID" value="RIE00322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00322">
        <property type="protein sequence ID" value="RIE00322"/>
        <property type="gene ID" value="D3H35_29200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="56"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE00322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="196" mass="21849" checksum="C2684C101AC4C75E" modified="2018-12-05" version="1">MALRLIWALLVDTPPSSDFLFMHNAALAAAKGDFSFASSDYYTSWAYQLGFTMYEALIVKLFGTPIIFLKVINVLWSTGTVALVYWTAGKAFNEFCGRAAAIAYAFYIPNIVMCSVLTNQHVSMFFFMLGCALLVHRGLTGKYSWLLIGLSFAIGHIMRPIGGVYIAALLVFVTVFRLFRGLLNARDRCLRRQPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CET4</accession>
    <name>A0A398CET4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MogA/MoaB family molybdenum cofactor biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00965">
        <property type="protein sequence ID" value="RIE00965"/>
        <property type="gene ID" value="D3H35_25740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="1">
        <location>
            <begin position="6"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="164" mass="18058" checksum="C34A3159F0176D1C" modified="2018-12-05" version="1">MRWKVALLTASDKGSRGEREDTSAQVIRELVEEELIGDIVDYRIVPDEQGEIRAALIEMADYYQADLVFTTGGTGLGFRDVTPEATLMIADRNVPGIAEAMRYASMQRSRRSALFRGVCVIRGRTLIVNLPGDPKGVHDHLMAVIDLLPEALEQVSGSRKGKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEX4</accession>
    <name>A0A398CEX4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_22140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01120">
        <property type="protein sequence ID" value="RIE01120"/>
        <property type="gene ID" value="D3H35_22140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="42"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="279" mass="30284" checksum="6EF6103B4261790E" modified="2018-12-05" version="1">MTIDFRMKPPIPAWERLFEEGRNAAGRWLNLRGLEPIPSETLDDVIGEMDAQGITHAVIMGRGNEPGSSNAELAAFLSGQTSNRFIGFIGADSPDIAGAVDAVETFAPTGLFRGVSLNPATLQPRTPIGDPSCDPLFEAARRHGLPLSITVSGLLGLSGESIDYDYARPAGLIRAAKAYPDLKIILSHGAWPFVSEAITAAIVCPNIYLSPDLYFRFPGSQLYVEAVNFQLSDQLLFGSCYPNVPYDFAISHFKSQNWNEGVLRKILYENGAKLLGLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF26</accession>
    <name>A0A398CF26_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_28170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000054">
        <property type="protein sequence ID" value="RIE00492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00492">
        <property type="protein sequence ID" value="RIE00492"/>
        <property type="gene ID" value="D3H35_28170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="155" mass="16937" checksum="1D412556271ABAB0" modified="2018-12-05" version="1">MELAQFKDKYDSGEIGYFFIPEVAGAENNGPNTSITAGLAYAFNKETFDAETKRFFKFVVEHYNQAAFDVGGYLSPMNGDLPSNVFKLAKDFSLDLEAVAKGGVSWDDKLDPASNEVVGSTANELALGLITPEEFAEKVDKAIGRNAPSFFKDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFL8</accession>
    <name>A0A398CFL8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage portal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01300">
        <property type="protein sequence ID" value="RIE01300"/>
        <property type="gene ID" value="D3H35_23235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018989">
        <property type="entry name" value="DUF2001"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038628">
        <property type="entry name" value="XkdM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09393">
        <property type="entry name" value="DUF2001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="154" mass="17270" checksum="F6A32C1F5F83A01A" modified="2018-12-05" version="1">MSFLLARDTINGQEGRAYAKINNVNEEMFYIKKLEATIEKSKAEIKTLGRRGTQHKATGWSGTGSMTIYYMTSKFRQLMLDYVKTGIDTYFEVSVVNEDPNSTVGQQTVTLKNVNLDKVIIAKLDTESEALDEDIEFTFEDVFIGTNFSAPALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFM2</accession>
    <name>A0A398CFM2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_24535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01523">
        <property type="protein sequence ID" value="RIE01523"/>
        <property type="gene ID" value="D3H35_24535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="344" mass="39888" checksum="30BDA8A27070E286" modified="2018-12-05" version="1">MTLTINEKEKKAIAAAVTERIDEYLGRFPFARYPIEPLDEWRHVFRNPKTVPTETLKQALGWQLGGWQRKDLPYAHRKTISEAIKAWPDFLQVAAHDPEQALDFWQDKLSDWQHGFGVAAFLLHLLWPDTFEIADRHRLDTMVELLKVIDHMEKDRTVALSLTDLQDYTAFLRSLVPKLPYGKESHIKLDRFIKIYGNRHAYKRISPDFVTREPLVRTFSWNTSSSSRYLLDQIAHRSNADLLFACFLLALEAENRSHEDLTIGEVIDMLPLGTGGLCNPASYNYAMVALFGGQKHRDYWSFHSPELRHAFTEQANQSTRNMRFYHTHASEKLSVNPKYVKAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFM6</accession>
    <name>A0A398CFM6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit beta</fullName>
            <ecNumber evidence="10">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">atpD</name>
        <name evidence="12" type="ORF">D3H35_14610</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="10"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01996">
        <property type="protein sequence ID" value="RIE01996"/>
        <property type="gene ID" value="D3H35_14610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="11">
        <location>
            <begin position="146"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="154"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE01996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="469" mass="50613" checksum="9A474249118E79FF" modified="2018-12-05" version="1">MSKGRIVQILGPVVDIEFDNGHLPDILNAIKIESQSGDRQIKLTVEVAQHLGDNLVRAVAMSSTDGLVRGTEVVDTGAPITVAVGPATLGRVFNVLGDPIDNAGEVDRSIVNPIHREAPTFENLSTQTEMLETGIKVVDLLAPYTKGGKIGLFGGAGVGKTVLMQELIHNIASEHGGISVFAGVGERTREGNDLYHEMSESGVISKLAMVFGQMNEPPGARMRVALTGLTMAEYFRDEEGRDVLLFVDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGQLQERITSTKKGSVTSIQAIYVPADDYTDPAPATAFAHLDSTTNLDRNIAAMGIFPAVDPLASSSRILTPEILGDEHYTVAQGVKRLLQRYKELLDIIAILGMDELSEEDKLVVLRARRIQLFLSQPLHVAEAFNGIPGVYVPIKETVRSFKEILDGKHDELPEPAFHNVGTIEDAVEKAKKLAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH65</accession>
    <name>A0A398CH65_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02556">
        <property type="protein sequence ID" value="RIE02556"/>
        <property type="gene ID" value="D3H35_17870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="131" mass="15584" checksum="131F7E7F92209ADD" modified="2018-12-05" version="1">MKRAITPDLFLKEFTVDISKNPAYVRELLEKAYIEQEADDVEYLMIAIFRFELFLEDITESICKLMNETWHFQHENIASMFQKVKSPRTIECLYNAALTQFEYLEYDEAFALAVKCIWALVTLIRLNQERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHI9</accession>
    <name>A0A398CHI9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00569">
        <property type="protein sequence ID" value="RIE00569"/>
        <property type="gene ID" value="D3H35_27940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024442">
        <property type="entry name" value="Transposase_Zn_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12760">
        <property type="entry name" value="Zn_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_Tnp_IS1595" evidence="1">
        <location>
            <begin position="31"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="328" mass="37659" checksum="D678355A05A12F08" modified="2018-12-05" version="1">MFANFSQGGCMMHLSLLQENMTFEQFCTRYRTERDCIEMLIRIRWPDGYRCPICACAHAYQISTRRLPLFECRSCRYQASVISGTIFEGSRTSLSRWFQAIYLHANPSGISATRLSEIIGVTYKTAWLIGHKLRHAMQTANNQDKLTGNVQISFDRYGSLSGGPQFIPKFNHPMVIGASINRQSETEQIMIRQIYDEPVEYFSTRFNGDEAFANEHVDISKAQLTKFLPFHNKNRSTSTSKLAILLDNWLNDTFHGIGAKHLQAYIDQFCYRFNMLKKKLSSSLDLLRWCAITATITYKSLVLLKTRRQALPLNSNTRKNRFVSAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHQ3</accession>
    <name>A0A398CHQ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02766">
        <property type="protein sequence ID" value="RIE02766"/>
        <property type="gene ID" value="D3H35_19190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="221" mass="26176" checksum="825D0C3F8BC13543" modified="2018-12-05" version="1">MMFEQKFALLLEEQKKKAGLRRLEMLQRDLSGTKRMLKVLWPALKTFDGITLEHEIISISGVKIFIDAFYEPLEFALESDGFVAHAEKITRDRFDFERMKIRTIAKYSYKYVPFSRDELDKKPEICLQSFYELVGRHGANLSRSNELLSVYEREVIRLGMTLHRSFSFGELMEYLQLGRQSSRKIMRGLLDKEMILLEGGSKQRFYRFRLSQKAKDWFICN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHQ6</accession>
    <name>A0A398CHQ6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation histidine kinase inhibitor Sda</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02776">
        <property type="protein sequence ID" value="RIE02776"/>
        <property type="gene ID" value="D3H35_19250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015064">
        <property type="entry name" value="Sda"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036916">
        <property type="entry name" value="Sda_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08970">
        <property type="entry name" value="Sda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100985">
        <property type="entry name" value="SSF100985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="47" mass="5706" checksum="56C784CFDD71F742" modified="2018-12-05" version="1">MLPLLSDELLLDAYRHAVRLSLDWDFVQMLRMEIRRRKLPLPEEQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHY7</accession>
    <name>A0A398CHY7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000054">
        <property type="protein sequence ID" value="RIE00498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00498">
        <property type="protein sequence ID" value="RIE00498"/>
        <property type="gene ID" value="D3H35_28205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="101" mass="10840" checksum="A8FEF9DC21244154" modified="2018-12-05" version="1">MKKGQGLIRVRGRKADGGDIIFEVEDNGGGMTAKQADALLADESIADPQAKGSGIGIRNVNQRIRYIFGKDYGVTVNSVPEKGQSSGSVSPLHCQRRHKQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI85</accession>
    <name>A0A398CI85_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_13130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01742">
        <property type="protein sequence ID" value="RIE01742"/>
        <property type="gene ID" value="D3H35_13130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="64"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="284" mass="31658" checksum="05013091AB1FEC29" modified="2018-12-05" version="1">MKVNKLGAILVSPSILFLSVILIIPLFYTIYISLYDMRYLQMGDFVGLKNYIKVFTSDDIMSSMLITFIVTFVGLFISIVTGTLLALWINSKKGFTAYIIQIIVLIPWVISMVVGALLWKWIFNNLGLLNYVLNSLGFQSVDVLGNPKAAPIALIFVIAWRTVGFAMVLILAGLKSIPKELEEAGEVDGASRWHTFWLIKLPLLKTPIMVTSIILMLSNFNNVDVPMVLTGGGPGDATNVITMELYDQGFVYYNFGVASALSFVVLMVNILLISLYIRMVKYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIJ6</accession>
    <name>A0A398CIJ6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_12910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03116">
        <property type="protein sequence ID" value="RIE03116"/>
        <property type="gene ID" value="D3H35_12910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="186" mass="20138" checksum="992245DD1A4F3530" modified="2018-12-05" version="1">MTTKSLMIDAATSLFQKKGYKSVGLNEILKACNVSKGALYHHFPNGKDELLIACLQALNEGIMADIEDIFSRHLSTIEAAQAMIDKLIYSLETEGTLSGFTFSSIVSEMATVSEPVRHACSALYENIQSIYYAKLVTDGFSNESASALALLMTASIEGAMMLCLTQKSIDPLKKIASLLPNVVKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIK9</accession>
    <name>A0A398CIK9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00688">
        <property type="protein sequence ID" value="RIE00688"/>
        <property type="gene ID" value="D3H35_27235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="43"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="294"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="407" mass="46445" checksum="3E6B5DBA9F0C20E8" modified="2018-12-05" version="1">MERYMSLLSPGDQPPALLGHEDIQAKLRKWITRRASGSEVSNSALIISLWGTEGAGKKTQLAHLGHYFNEPMLFVDMTKVPEEEREGPDALDNVFREAAIQQALPVLCGFLLQEDSEAMRNRKRELLDRLKTMSGIVFVLSEQPCQPIDLRSRIDLELEIPPLEGEKRSDAWRTLAAAYEVDESVDWGILASRFVFSPGQMSNAMRTARTLSEWRQEEGKSGPIRWSDMVEACYKQLNHHLDAKAKRLTPKKRWEDLVLPEAQTKKLRHACNHIQYKHTVYGLWGFDKKLSYGTGVSLLFSGPPGTGKTMAAEVVAKELDMEIYKIDLSQIISKYIGETEKNLREIFDEAEKSCAILFFDEADALFGKRSEVKDSHDKNANTEVAFLLQKIEEYGEYRLWRRTICKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIN1</accession>
    <name>A0A398CIN1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01932">
        <property type="protein sequence ID" value="RIE01932"/>
        <property type="gene ID" value="D3H35_14250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="80" mass="8946" checksum="E208AA007452D357" modified="2018-12-05" version="1">MQMKNMSRTLKWISVVIIALGILCCIWNISQFNDRNLGLMVGIGFLVGGAQILIFGTIAPLMQKRQDEERLPESLAKDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ83</accession>
    <name>A0A398CJ83_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000043">
        <property type="protein sequence ID" value="RIE00888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00888">
        <property type="protein sequence ID" value="RIE00888"/>
        <property type="gene ID" value="D3H35_25880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="64" mass="7159" checksum="8C5708CDEED94713" modified="2018-12-05" version="1">MKKITMKDIAKEAKVSTATVSYILNSVESQSISEDTKEKVMKAAQKLNYIRNLNARTLKAENPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJM9</accession>
    <name>A0A398CJM9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NCS2 family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_16630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02342">
        <property type="protein sequence ID" value="RIE02342"/>
        <property type="gene ID" value="D3H35_16630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026033">
        <property type="entry name" value="Azg-like_bact_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005353">
        <property type="entry name" value="PbuG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="469" mass="49446" checksum="911A6ABFF8C2E6D4" modified="2018-12-05" version="1">MERFFKLKELGTNVRTEIMAGLTTFMTMAYILAVNPNTLSAFGSGATGGEWYPIFLATALAAGIFTIAMGIFVNFPVALAPGMGLNAYFASVILSSSATGKPVTFEIALTAVFISGLIFILLTVTKVRQMLLVAMPEGLKHAITVGIGLFITIIGLKNSGLLTVGVEAGSDIAKGKFTDVAFFETVFHMGSLESPGVQLVLIGLILISILMVLRVKGAILFGILGTTLIGIILGSDYVSTTINTDVTPWIPNLSEVAFANFDWDGVFQTGLISIVATFTFVELFDTFGTLVGTANRAGLMKNPEEGNKRVGKAMLVDAVAVSGGALLGTSTTTAYVESAAGVAEGGRTGLTAVSTGVFFLLALFLAPIVNLIPGSATAAALIIVGLLMLQSVKNIDFQDYTIAIPSFLTIVLMPFTYNIANGISFGIVSYVVLATMVNLFGKGKYKVHWLMWILAILVVARYAFIGSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK71</accession>
    <name>A0A398CK71_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_10445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03706">
        <property type="protein sequence ID" value="RIE03706"/>
        <property type="gene ID" value="D3H35_10445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017350256" evidence="2">
        <location>
            <begin position="32"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="290" mass="29248" checksum="8711F65775A9FABA" modified="2018-12-05" version="1">MSKIQMPLLTAALMLLAIWLAGCSDQNLAGAPAEATSGSEESSSAGSEPSASPEAFGDASESVVPEEDSQDASRSPESPLASEPENAPIESSAPAEEKPAASPKLEPKNEGEKKTGNGEKADAAKDNKASVATPPKGTPSPSAKPTPSAQSAQNGEPKPDNAGSGIMGKIKSISGNSITVYIASAPGHPGEAPPKDGKESAEPKEPFSAETQAVIVTDGTKIVSVTFENEKRTETAIKLAGLKAGAFVMIELDGSTQNAKSIALQAEGQRGPGPEGRGPAPSGAPQGTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKC9</accession>
    <name>A0A398CKC9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein-glutamate O-methyltransferase CheR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02612">
        <property type="protein sequence ID" value="RIE02612"/>
        <property type="gene ID" value="D3H35_18185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="280" mass="32535" checksum="55973C94E80F2E5B" modified="2018-12-05" version="1">MTNHSHDVDPDTEKIEIALLLEGIFRKYGHDFRRYSYSTMRRRVWHRIHLEGLPTVSALLEKVLHDGVLFHRLLRDLVIPVTEMFRDPDMFLSFRRNVVPILREIPYVRIWHAGCSTGEEAYSMAVLLHEEGLLDKTRIYATDISEDALSRAKEGFIPIDRMKLYTKNYQASGGLASFSDYYVAEHGLVMLKPSLRKNIVFARHNLVTDRSFNEFHVILCRNVMIYFDGELRDRVHGLFHESLASGGFLTVGSKESITFTSRSGCYDAFDDRNRIYRKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKE3</accession>
    <name>A0A398CKE3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01348">
        <property type="protein sequence ID" value="RIE01348"/>
        <property type="gene ID" value="D3H35_23535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="172" mass="19457" checksum="E0FFDD888999BA7F" modified="2018-12-05" version="1">MKYLNLLPRRSLWQRYFVRLMVLIVTITIASVTILVYGFVSNRSEGNLLKQGIAELESQIQTLSSGPKEDPYVAAYSGLERSYNVIRSQWIDWISLTAIIRSPLPSEASIKTIQVEANHTVKVQYGFGNMDDVIPYMAEMKQAQIVNDVSLNSYSKGSGDLAYDVHMTIKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKU6</accession>
    <name>A0A398CKU6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Efem/EfeO family lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_20610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EfeM/EfeO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03005">
        <property type="protein sequence ID" value="RIE03005"/>
        <property type="gene ID" value="D3H35_20610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14656">
        <property type="entry name" value="Imelysin-like_EfeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018976">
        <property type="entry name" value="Imelysin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034981">
        <property type="entry name" value="Imelysin-like_EfeO/Algp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038352">
        <property type="entry name" value="Imelysin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09375">
        <property type="entry name" value="Peptidase_M75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017279123" evidence="4">
        <location>
            <begin position="23"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M75" evidence="5">
        <location>
            <begin position="159"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="393" mass="43273" checksum="7F26681EBCC4F693" modified="2018-12-05" version="1">MKKPLVLAYASLAALLMLSACGKENDNSPASASASASAAPSEGASSDDKGAIRQGTIKLQEETTKLQDAIEKKDADEVKRIGKSINDAWLSYENTVRQIFPLEYTDVEKYEMPIFSASAYDKVDFDALKVTAAKLQEALTKLLNAKETTANTSELLNKAVANYKVYVDEQAANLANQTKVLAAAVKSGNIEQAKLEYAKGRVYFENIEPIAETFGDLDPKIDARLADVENESEWTGYHRIEKALWVDNNLQGQEKYADQLISDTEELQKQIQGLKLEPKAMVAGAMELLNEAATSKITGEEELYSHLDLIDLAANVDGSKTVYLAIIPALNEKNPELGNQLDKQFLAMEETLRGFQKNGVFVLYNELTTEQIRQISDQLSQLSNLMSQTASIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLG7</accession>
    <name>A0A398CLG7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AI-2E family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_21040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03072">
        <property type="protein sequence ID" value="RIE03072"/>
        <property type="gene ID" value="D3H35_21040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="356" mass="40016" checksum="CF795FCE496F6C41" modified="2018-12-05" version="1">MNRFTQNRLFSLMVYVILGLLTLYLIMLVRPMLLSVYDFLKAVLAPFLVAMVISYVLNPIVNLLHDRKVPRTAAVLLIYAVFITCCVVVLMNVIPMFMGQVEELNEHMPNLTMKAESLVDHFNNNRLLPSSVRDGINRSIAGLEKQIEERIADFLNNIGAVMNVLFIAMIVPFLAFYIMKDMDVFERAAIQYVPRARRKQAVRLLKDIDSALGSYIRGQFIVSLCIGVLAYIGYLIIGMPYPLLMAMFVSLFDIIPYLGPFFGALPALVMATTVSWKMVLLVAIVNIVCQNLESNVISPQVVGKSMHMHPLTIIFVLLVGGELAGIIGMIMAVPFYAALKVVVQHVFAYYIRRKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLH6</accession>
    <name>A0A398CLH6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03513">
        <property type="protein sequence ID" value="RIE03513"/>
        <property type="gene ID" value="D3H35_11955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="133" mass="15383" checksum="2BDBE2A620C6F990" modified="2018-12-05" version="1">MAELGYPTSISDMERRMDRMTADPEAHTFVASLSGEVIGMIGVKRLYNYETDDFLTYISCLVVKQKCRGQGFGKKLLHFIEEWSVREGMNVLYLTSGIKEERKPAHELYKQMGFEITGYRFIKKLEAKQQQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLS0</accession>
    <name>A0A398CLS0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_13515</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01808">
        <property type="protein sequence ID" value="RIE01808"/>
        <property type="gene ID" value="D3H35_13515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011623">
        <property type="entry name" value="7TMR_DISM_rcpt_extracell_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07695">
        <property type="entry name" value="7TMR-DISM_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="436"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="692"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="920"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE01808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1024" mass="115173" checksum="CD3D4D9F4637CE66" modified="2018-12-05" version="1">MNKQLAVLLGMIGIFFIVTLIFIWDWLNPPGEFPEARNGVLDARQWDFAEQGVIPLSGQWEFYEGQLLGPDDFRSGWKSMQARPQLVKVPGSWQRAVNSVRGEGFGAGTYRLLVDVNREDIYSLRAKKIRLSSHIYINGTDVGGTGRPALTAEDFVPSNVPFFGTAAANAGQVEIIMQVASFEFFQGGLVQAPIFGLTGDVMADRDNSRLADMILITTLLVFGLYYVGMFKQWRKEPHIMYFSLFCLSTGLFFSLDDEILATTLIPSLSFPWLQKMIFIFPYMTFLFFFRYVYSYLGEKESTFIRLLRQFSYMYLALAVIVPNSYLTRLFSLGIALQILCFFAIFYAIFHSRRRETHGGYYVTLGVFFLIFTWIYGQFRYLLALDNPYYIIVTPLLLVFSQAFLMSDRIRDAFQRSDRLTTRLLQYDRQKDEFLATTSHEIRTPLHGIINLSQALLDNQDTPLRPEHRENIQLLHLIGRRLAGLVHDILDMNRIRYGQLSIHPTAVNVGTSVRFVMETLSVSSINREVKLVSELPRKLPLVRADENRLRQILHNLMENGLKYTDRGTVKISAEVREDELALTVEDTGRGIPTDAFADLFQPFVQYQEDSSGSRDGIGLGLSISKQLVELQGGRLEVESEVGVGSRFTFTLPIAHSEEEAAATTEWTGTGAAAEETTAPLSGSLQGGKAAEFHILIVDDEPSNLKVLIDAVTSMRHAYTAVGSGREALDTLLRAPKPDLVLLDLMMPGLSGLEVCREIRSLRGLAELPVLMLTASGQTGDILASFNAGANDIVQKPFEMAELKARVRSLLAMKNSSEQAIRREMDFLQAQITPHFLYNSLNALVGLSYKDVDKLRETIHHLTTYLRGKFTFVFQGEFVAFEREMELVQAYLAIEQLRFGSRLRVRYRNEDEIRCLLPPLTLQPIVENAVRHGIGQKPSGGTIDISVSRSTDGVEIIVEDDGVGMDDDALRSLNKGGASGVGIGNVNRRLQMLYGRKLEIRSSPGQGTQVKLVIPEDNYVERNIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLU6</accession>
    <name>A0A398CLU6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YcxB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_12170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03415">
        <property type="protein sequence ID" value="RIE03415"/>
        <property type="gene ID" value="D3H35_12170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025588">
        <property type="entry name" value="YcxB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14317">
        <property type="entry name" value="YcxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="YcxB" evidence="2">
        <location>
            <begin position="99"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="167" mass="19462" checksum="1D17F42F98271CBD" modified="2018-12-05" version="1">MNSEPLLSTNYQVTLEDYTEFVLFHSRMSIRFFPLFNIVLFVCWALLAGADASSLGILISLGIVITLLFTIFFVVFLKIKAKRVFKSNKLLRQEYVFQFFEQGINMETDTSKGLIQWNEIYRVSESKKLFIIYIAQNQGMILPKSLVDEQKLRSIIHTYFNKKAIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMD1</accession>
    <name>A0A398CMD1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_14450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01968">
        <property type="protein sequence ID" value="RIE01968"/>
        <property type="gene ID" value="D3H35_14450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="195" mass="22201" checksum="28CF87BE888F3AAC" modified="2018-12-05" version="1">MPEGGKGGRAMNENKKKTGFGKQLAELHRWNGWLVVLLAVTGLVLSWGAVRGWLGEGRVWIKQLHIGVGVVSGILLVMYAPLMRRHWKQIRNRPSQKRNLSVMLILLVGWLLSGIVLWQFRHLPPRWANNALVVHDLLTWVGMPYILFHSITRIQWMRRPERRTIRAEAGESAEALQPGGYRSPTRHNGLRVASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMI0</accession>
    <name>A0A398CMI0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_12435</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03460">
        <property type="protein sequence ID" value="RIE03460"/>
        <property type="gene ID" value="D3H35_12435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="196"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="263"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE03460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="500" mass="56541" checksum="270B8582AEC6C772" modified="2018-12-05" version="1">MSIRFKLILSYAAMLVVPLLLLVMTTLLLVVVYRGHFPNLANFYETKVEGFEQSDYNRLLNHTIAGNPELLSNPEYLEGLSSEMKTKDAFLVIRMEGRTVYASEGIRSRTDVLSSLPAFSHESFRNVIAAKSYGNELFSILQYDLMSKKREPVSLFILMEVDPVVLFARQSFPILLVSFLVILVLTHAVLTYFMSKNIIRPLGELRKAAGQIKEGNLDYRVQVQGKDEIGQLGIAFEEMRGRLQHSVELQQQYEENRKELVANISHDLKTPITAIRGYVDGILEGVADSPEKTEAYMRTISAKAAEMDHLIEELFLYSKLDLNRVPFFFESVSFRAFLEDWAEELHFELEKRGVQLAVELELDNDVIASVDRDSFRRVLVNVIQNSLKYMDKPSKRIVLRSYCRGDAVVLEIADNGPGISEQALPHIFDRFFRAEQSRNAETGGSGLGLAIAKQIMEGHGGDIVAESLEGEWTRLILSLPIQKGGHSGREKNDTDRGRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMV5</accession>
    <name>A0A398CMV5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03805">
        <property type="protein sequence ID" value="RIE03805"/>
        <property type="gene ID" value="D3H35_09635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="212"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="390" mass="42951" checksum="CCF50F5917E9EABD" modified="2018-12-05" version="1">MNVPIYMGSSSGFGEGGLGGHLGFIYRAAQSTGRDIRVICRGQPQLPDGEFVSVPPPVWAKNVKYTPLRWSPALQTNWSGSQFDRIAASRLPNEPIVYHSFPGFAENSFRKVKKRGGITVLEAATTHAQNVYEVTEEEHRRFGMGGNHFSRGWLKRVLQEYELADFITIASDLQRQTFLDRGFPAEKLLYAPLGIDTNRFSPPADGIRRRTPGQPFRIVQVGQVTLRKGFLYLLEAVRRLNDPDIEIILFGGIGWRAIRHSLASYRQLGIGVRQQSGDPLSVLRDAHLCVHASVEDGFGLAPLEAMAAGLPVIVSDQTGMKDLVEHGKEGFIVPSRDADRLAEAIAGLKRNEEARRAMGAAAAAKAKQYDASACADRYAEALRPAWVNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMW0</accession>
    <name>A0A398CMW0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02128">
        <property type="protein sequence ID" value="RIE02128"/>
        <property type="gene ID" value="D3H35_15330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="65" mass="7043" checksum="D0DD5FA531545054" modified="2018-12-05" version="1">MVGLFGEKAYECEPQPNVVGLSGGIAYECEPQPNVVGLSNGIAYEREPQPNVVGLFGEKAYERKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMW1</accession>
    <name>A0A398CMW1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03632">
        <property type="protein sequence ID" value="RIE03632"/>
        <property type="gene ID" value="D3H35_10035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="69" mass="7605" checksum="57D10C63538FA4C9" modified="2018-12-05" version="1">MLARQRACIPFVRSVSRHLRPLPMGRLFVVSVLLAESAGNRFVGAPGASPYSKCEYGVKRPQGERSFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMY9</accession>
    <name>A0A398CMY9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000035">
        <property type="protein sequence ID" value="RIE03600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03600">
        <property type="protein sequence ID" value="RIE03600"/>
        <property type="gene ID" value="D3H35_10700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="69" mass="7738" checksum="74BBED61FBCF4355" modified="2018-12-05" version="1">MDVSYEDPNNGVLEEQSFEFNDKSVATGRFVVALQDANRRQVGFKATIIRKDGTLSEVPQSYTSRDVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN01</accession>
    <name>A0A398CN01_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01287">
        <property type="protein sequence ID" value="RIE01287"/>
        <property type="gene ID" value="D3H35_23155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="307" mass="34662" checksum="AEA1A0CF5F719BBD" modified="2018-12-05" version="1">MMKKVTIKDIAKEASVSIATVSYILNAVGNQSISEETREKVMKAAQKLNYIRNLNARTLKSGKSELIGILLPQTSGDSYWSTYRYTEAVRLLGKHLNRQGYHLIVSYIDPIAPKLDVVLEREMDGVFVLNASQKMFYQISKRFGVGIPLIGIDIYNEDPLFHKLIPDFDAAFAKASEALGRRFDFLIIDDYRDKLLLDRIKQSSGLEDDSIHVYSGDKKLRSFLSGRSGQFGCAINEFLFTRIMNEPFDGKLAALCTSGCPELLPPSVPKVVFNLDAYRIASELMIHYIRKPHESIEPKITLLAMQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN23</accession>
    <name>A0A398CN23_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_25340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00981">
        <property type="protein sequence ID" value="RIE00981"/>
        <property type="gene ID" value="D3H35_25340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031564">
        <property type="entry name" value="Flp1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16982">
        <property type="entry name" value="Flp1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Flp1_like" evidence="2">
        <location>
            <begin position="16"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="65" mass="7137" checksum="E3AA2C45E9C1F053" modified="2018-12-05" version="1">MTACYLGAVRKLESLAEDEEGIGTLEIVLIAAVIIAIALLFKDWILDFLESLMDKVEGKSDTFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN66</accession>
    <name>A0A398CN66_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03925">
        <property type="protein sequence ID" value="RIE03925"/>
        <property type="gene ID" value="D3H35_08145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="275" mass="31703" checksum="09663DF5A6726018" modified="2018-12-05" version="1">MEGFGVWTGRVRKEASLSVSIASVKPGEEMDAMKSYNCQMVKIGNCLRTKRYGRKIYEGGKNPRRSKAERSAEIAEVADNPLLSKLEKLIHTAILEPSKREEHAGKRPDRTPKPGRLTLSERERFCHLMDRNFCEGHKFLTLTYEKEDVSLDESVRDFENWVKRMRERYDDFKYLAVRSFQRSGTLHYHLLADLPTIPRAELADGTFSAIWGHGSVDLRRIYCLPMEGHLRAILGPMTVEDVYRNRDEFARNVAEKAGGRQHGDEERHYPTVTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNA8</accession>
    <name>A0A398CNA8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_09570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CpsD/CapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03792">
        <property type="protein sequence ID" value="RIE03792"/>
        <property type="gene ID" value="D3H35_09570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="AAA_31" evidence="9">
        <location>
            <begin position="41"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="216" mass="23540" checksum="CED1C5B5A5D50F9B" modified="2018-12-05" version="1">MSKSTAKPALLMELNPLSQISEIYHSLRSNIEFSTAKQEARVLALTSSHRGEGKTTTAVNLALAYSRSGKKVLLVDADLRNPSLHSILDQPRREGLSNYLLDQSAIWDVIKETSYPNLHVITSGALPANPTELLSSKNLSELFKELKGTFDRIIVDSPPLLSAADSQILASSTDGVVLVIEYAKTPRAQIQKAAKTLEHIGTPLLGTVINKSKRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNF6</accession>
    <name>A0A398CNF6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01111">
        <property type="protein sequence ID" value="RIE01111"/>
        <property type="gene ID" value="D3H35_22095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017285625" evidence="1">
        <location>
            <begin position="28"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="162" mass="18264" checksum="387532968B4BE936" modified="2018-12-05" version="1">MKKMNSVRGLVLFLGVIAFAIPVQVLAEENAINHSQALTSAPQFLFTPFTVFDPNYTYLEKGQGYLTYEGNGKVNIWGETYGTVKADEISVQLTLQRWTGTVWVDAYYAANQAESNSAYVYSSISHILVSSGYYYRTKSYHWIRKGATTESGYRYSSSYLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNL3</accession>
    <name>A0A398CNL3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEPN_AbiU2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01507">
        <property type="protein sequence ID" value="RIE01507"/>
        <property type="gene ID" value="D3H35_24445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040704">
        <property type="entry name" value="HEPN_AbiU2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18734">
        <property type="entry name" value="HEPN_AbiU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN_AbiU2" evidence="1">
        <location>
            <begin position="41"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="229" mass="26075" checksum="ED711532170BA1CB" modified="2018-12-05" version="1">MQAGLCGLFGDNQRECLKEFREGGMNKVTKETSQLTQYVILMQVEVIQLLEDFAVWLGFKDDKFKKVSEQTIPTISKAIRQSLLTNILISTCKLYEYPGRNTANVSLRRFLDYFKQNFDKIVQSPVHKNLTIADIEDDLEKIDELNKAITSTFNLRNKILGHIDINYIGDAGKHLADSVRSRDSLLKLINTAAVIIQKHMKPLMCGDLIYPATVASEIKVLKKSLKDYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNU2</accession>
    <name>A0A398CNU2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-hairpin-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_05945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04165">
        <property type="protein sequence ID" value="RIE04165"/>
        <property type="gene ID" value="D3H35_05945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004509">
        <property type="entry name" value="Competence_ComEA_HhH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00426">
        <property type="entry name" value="TIGR00426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017380908" evidence="2">
        <location>
            <begin position="40"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="3">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="3">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="185" mass="19242" checksum="85093A35F9B3CB1A" modified="2018-12-05" version="1">MLDSSQGRRSIRKMAAYAAVAAGTLLLAVALLLPSNKPAVPGWETVNGEVGARLVTTPDDLGQTGEQAGRSASINTAPIPSSQPSATTPNFSTSSPEPSHNSSAPAASPSPEPLRIADQAGKLDLNSATLAELDELPGIGPAKAKAIADYRDKRGKFKSVDELSSIKGIGTKLMEKIRPLVFVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP03</accession>
    <name>A0A398CP03_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA 2'-phosphotransferase</fullName>
            <ecNumber evidence="5">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kptA</name>
        <name evidence="6" type="ORF">D3H35_27200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR&gt;P). May function as an ADP-ribosylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00654">
        <property type="protein sequence ID" value="RIE00654"/>
        <property type="gene ID" value="D3H35_27200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00299">
        <property type="entry name" value="KptA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022928">
        <property type="entry name" value="RNA_2'-PTrans_KptA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PTHR12684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="184" mass="20689" checksum="42D9EEFBD4C37213" modified="2018-12-05" version="1">MLGKEMETSLSKFMTKLLRHTPEEYGLILDSSDGSCLMDELLFVIQSQPKWAWVKENHIRQVVNHCEKQRFEIAGQQIKARYGHSHSKVTYDPGIPPLTLFHGTTRKAAPIILKEGIHSMNRQYVHLSEGTHFASLAGSRRGELVILRIDTAKAAQSGVTFFCAGNEVWLAESIPSLCCSIYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP41</accession>
    <name>A0A398CP41_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3055 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_06960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04333">
        <property type="protein sequence ID" value="RIE04333"/>
        <property type="gene ID" value="D3H35_06960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021415">
        <property type="entry name" value="DUF3055"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11256">
        <property type="entry name" value="DUF3055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="96" mass="10893" checksum="844DBB69FC9B5526" modified="2018-12-05" version="1">MFESLYDVLEASNVNFVGCVSDESRFDFAIVYTSHFFGKPLVVCMQTGRSAPLCADDLRDTDILRSRFQVSDSQALEELGTLLRSRLPSLEMQDQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP84</accession>
    <name>A0A398CP84_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_06970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04335">
        <property type="protein sequence ID" value="RIE04335"/>
        <property type="gene ID" value="D3H35_06970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00615">
        <property type="entry name" value="Orn_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000310">
        <property type="entry name" value="Orn/Lys/Arg_deCO2ase_major_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008286">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036633">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01276">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03711">
        <property type="entry name" value="OKR_DC_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55904">
        <property type="entry name" value="SSF55904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00703">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OKR_DC_1" evidence="3">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="489" mass="53455" checksum="DB60653267D5A5DB" modified="2018-12-05" version="1">MDHTRTPLFDALKHHAERNPVQFHIPGHKKGAGMDPEFRDYIGSNVLNIDLINIAPLDDLHQPIGVIQEAQQLAAAAFGADATFFSVQGTSTAIMAMILSVCGHGDKIIIPRNVHKSILSAIIFAGARPVFLSPARDHNLGIDHGVTTKSVRRALERHPDAAAVLIINPTYYGVCANLKEIVDLVHEYDVPVLVDEAHGALIHFSDELPLSAMQAGADMAATSVHKLGGSMTQSSILNVRANLINTFRVQTILSLLTTTSTSYPLLASLDAARRQLALRGNELAARTVALANKARDAVNAIDGLYSFGEEILGEEATFDHDPTKLTIHVRKLGITGYDAENWLREHYNIEVELSDMYNILCLITPGDDEGSIDILLEALKNMSEAHLGTREVQEIIVKIPEIPHLSLTPRDAFYGETELIPFRESAGRIIAEFIYVYPPGIPILLPGEIISQENIDYIVDHLEVGLPVKGPEDRSVTNVKVIVEETAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP86</accession>
    <name>A0A398CP86_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_01465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05216">
        <property type="protein sequence ID" value="RIE05216"/>
        <property type="gene ID" value="D3H35_01465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012700">
        <property type="entry name" value="CP_lyase_PhnK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037116">
        <property type="entry name" value="CP_lyase_PhnK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="283" mass="31155" checksum="A1765BB7418B8AFB" modified="2018-12-05" version="1">MSSLAMDAPILTVHDLNKQFGDGCIRCAGGADRRLEKNYCPACGTVYSCQNLSFELYPGEVLGVVGESGSGKSTLMRALYFDQQVTSGEAYLSCYKDGLSNLFAQSSQQQRYIRNHLMGMVYQNPLAGLRMGFSSIGNIAEKMIAAGNRNVAAMETRGSDLLERVHIPLYRRKEAPKNFSGGMQQRVQIAKAMSNNPPILLLDEVTTGLDLSVQANVLDLIKHLQRELGISMLLVSHDLGVIRMMADRTLVMLDGKVVEQGLTDQILEDPQHAYTQQLVHSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP96</accession>
    <name>A0A398CP96_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05226">
        <property type="protein sequence ID" value="RIE05226"/>
        <property type="gene ID" value="D3H35_01515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="159" mass="17884" checksum="D0037E59145F3379" modified="2018-12-05" version="1">MKGQLLVCDDIQFDRAEKSHRLGKVINAMHASVLPYVETLHIFAKLSEIPAHETIDIVITIRDEEEETIGMLESFATRNHRSEDQPPGVDISTTIAATICLTGPIQIDLYANGEWLDRYSLVVRLQHVAGEVVPDKRIISLETSHLLGIDIDTRFPTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP97</accession>
    <name>A0A398CP97_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02538">
        <property type="protein sequence ID" value="RIE02538"/>
        <property type="gene ID" value="D3H35_17770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="1">
        <location>
            <begin position="38"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="325" mass="35279" checksum="399DBD6F49CCD629" modified="2018-12-05" version="1">MMRIGACMLVSLVLMAGLLNGCSRKGEIRTAPERQTNVALIVKDRSGEFWKTVKMGAEAAAKEFNVNLMFDGTDSETDASEQSALVEKYVAYGANAIVLASEDYVKLAKAVEAADRKGASVIAIESEVDSPKVRSFIGIDNYEAGRQAARKMSEVAGAKGSFVIIGHSSGDRNSAQREKGIRDEWAATPGIKIEETVYCGSEKGSCKKKTEELLMRQGQLDGILALNAAASAEAASEIEAMNRQGKVKLVAFDNSPEELEWLQEGVIQATVIQNPFSMGYLGVKTAVDAINREKVAKRTVTETKVIDAESMFWSDNQKMLFPFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPB3</accession>
    <name>A0A398CPB3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04365">
        <property type="protein sequence ID" value="RIE04365"/>
        <property type="gene ID" value="D3H35_07165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="253" mass="27060" checksum="C83665FC8ACDA3B2" modified="2018-12-05" version="1">MGFQAVIRQAAWLALCGAGLSGCLGAKTELPADQAFARSASALSGTDHYGFTGEVAVVGVSGFVAGRSTYKGEVSDHGLLNIKWNGAGASQGELTTANTEKEGSASLHPFQLLKALENGTATISYDEAAASPAAVVFRIRLTDESARQRMADGLKAEMAQLRDSLNESKLGGARKAEAEAVLRDADKTLAAALSTLSAETECVWTADRRTWFPSRLKEETKLSYTWQGKPREERRVSETNFLRNPQSDTIGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPB9</accession>
    <name>A0A398CPB9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TerC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04232">
        <property type="protein sequence ID" value="RIE04232"/>
        <property type="gene ID" value="D3H35_06340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022301">
        <property type="entry name" value="Integral_membrane_YjbE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03717">
        <property type="entry name" value="R_switched_YjbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="221" mass="22986" checksum="42015BC095BFB2C8" modified="2018-12-05" version="1">MGLLENVVVFIEIVLINLLLSGDNAVVIAMAGRRLPADKRRRAVWWGAAAAVMLRIVLTLGAVALLHIPFLQTVGAVLLFVIALQLIAENKGESAHSTAATTLAGAVWTIVVADFVMSLDNVLAVAAIADGDVAMLVIGIAMSIPIIIWGSSFIMSLIDRIPALVYVGGALLGYAAGEMALKDPGLRSVIPVSGQLESVLPFALVALLMASALIVRAGRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPC8</accession>
    <name>A0A398CPC8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thiamine-phosphate synthase</fullName>
            <shortName evidence="8">TP synthase</shortName>
            <shortName evidence="8">TPS</shortName>
            <ecNumber evidence="8">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="8">TMP pyrophosphorylase</shortName>
            <shortName evidence="8">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">thiE</name>
        <name evidence="12" type="ORF">D3H35_17295</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 8 9">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8 9">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 8 10">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03169">
        <property type="protein sequence ID" value="RIE03169"/>
        <property type="gene ID" value="D3H35_17295"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TMP-TENI" evidence="11">
        <location>
            <begin position="6"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="8">
        <location>
            <begin position="36"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="132"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE03169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="205" mass="22356" checksum="3022CB315BD059CA" modified="2018-12-05" version="1">MKDFRLYAITGEQFHPNRDLIEVMEEAILGGVDIVQLRDKTSGKQELLRKARALRELTRKHDVTFIVNDHIDIAMEVDADGIHLGQGDLPLPEARKIVGGKIIGISTHALQEALLAESQGADYIGVGPVFRTATKADVVDPVSVRYVREVAQFIKIPFVAIGGIKLNNVDEVIDAGATRICAVSEIVGSSDVRGTCEAFLGKLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPE2</accession>
    <name>A0A398CPE2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Winged helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_13325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01777">
        <property type="protein sequence ID" value="RIE01777"/>
        <property type="gene ID" value="D3H35_13325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="393" mass="46060" checksum="663DAE7668158ADD" modified="2018-12-05" version="1">MAAIMLTKLQARTFLLFYQGLNDGCESMGKEGILSYIRRVGCIQFDPLNVVGMNPELVLQSRIKDFDRSMLWELLYQDRKLIDYWDKNMSIFPLEDWPFFSRCRSSHQAWCHSNKGAIERVYTEIETRGALCSGDLDYEEKVDWAWGPTRLSRAALEGMYHAGHLVIHHKARTRKYYDLAERVIPQDLYALPDPFETDEQYYDWYVLRRIGSVGLLWNRPSDAWLGISGMKSLQRNESFARLLAAKKITEITVEGLQQPLYIRSADLDVLDRALTHASTSTEKQSRILAPLDNLLWDRVLIKELFDFDYRWEVYKPAAERKYGYYVLPVVYGDTIVARFEPVKYQQNAPLSIKNWWWENPSSVNSEMNEGVIRCLERFASFLGTTFQRTDFKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPG4</accession>
    <name>A0A398CPG4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00824">
        <property type="protein sequence ID" value="RIE00824"/>
        <property type="gene ID" value="D3H35_26960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="128" mass="15004" checksum="27DE1236A04E8222" modified="2018-12-05" version="1">MIEDFFSLDDGEPVQRIHQDVEFEIDYWQADLDGVGSIVSEFVRPFSLDQAPLLRVGLIRLSEQRHMMLYDLHHIIADGLSMEILEREFIEIYHGKVLNRYACNTKIFRNGSAMYFLMNRLQSKSDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPH2</accession>
    <name>A0A398CPH2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_08910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04060">
        <property type="protein sequence ID" value="RIE04060"/>
        <property type="gene ID" value="D3H35_08910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="339" mass="37417" checksum="EFC353705B695865" modified="2018-12-05" version="1">MKLKLGVLDQSPIGRGETAATALQHTLALARAAERWGYSRFWVSEHHDSKSLAGSSPEVLLAAIGAHTSRIRIGSGGVLLPHYSPYKVAENFRVLEGLYAGRVDLGIGRAPGGMPLSSRALRKDSPKEPDEHFPQSLRELAAYIGKGERLEPTHPFAELNASPHVDTTPEVWLLGSSIYSAAVAAQMGAGFSFAHFINGEGGQGAVRDYLKHFRPGPLGDRPNVSACVFVICAETDEAAEGEARLTDLRLLYLEKGQFQQPFPTMEEANAYPYCDWDRLRITENRKRIIVGGPSKVKKELESFADSYRTNEILVTCIMSDFNKRVRSYERLADLFELLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPX2</accession>
    <name>A0A398CPX2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_13920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01877">
        <property type="protein sequence ID" value="RIE01877"/>
        <property type="gene ID" value="D3H35_13920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="86" mass="9534" checksum="72B4E80F4BB61CE5" modified="2018-12-05" version="1">MVTHPTATASNWIRVPRAVLLPPASFGFRLAADTLAPGYGRRLPAPIPDFHRIDDAHAGRTKKDLEDCRPQGLNINLMIIYPVVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQE6</accession>
    <name>A0A398CQE6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_21905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01651">
        <property type="protein sequence ID" value="RIE01651"/>
        <property type="gene ID" value="D3H35_21905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="285" mass="31291" checksum="0C6EE0CCD7DF84A9" modified="2018-12-05" version="1">MSRLSTQKLSLAYGNRPIVQELNLHVPDGLITALVGSNGSGKSTILKSMARILNPVSGGVYLDGKLIHRQATKEVAKQLAILPQNPISPEGLTVRELVSFGRYPHQKGFGSLRAEDARMIQWALQATGMEAFGDRPVDQLSGGQRQRAWIAMAVAQDTEVLLLDEPTTFLDMAHQIEVMTLLEKLNREQKRTIIMVVHDLNHAARYAQHLVALKQGTVLYEGKPEEVMTSEMLRAVFNIDADVIPDPRTGSPLCLPYGLAEEEESGLESASAEFESVPEKIAVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQP8</accession>
    <name>A0A398CQP8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_13875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03128">
        <property type="protein sequence ID" value="RIE03128"/>
        <property type="gene ID" value="D3H35_13875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="124" mass="12981" checksum="7D98AA338B4A844B" modified="2018-12-05" version="1">MSDTQHTDNSNAKANPASRNRAWAYVLLGGALEIIWASGFKYDAVPMIVVIISLLVSFDLIVRATKVLPVGTTYAVFAGIGTVGMVVVEAVAEGGEIGLGKVGLVLLLLLFIIGLKLTSGKEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQS0</accession>
    <name>A0A398CQS0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_13290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01771">
        <property type="protein sequence ID" value="RIE01771"/>
        <property type="gene ID" value="D3H35_13290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="309" mass="34393" checksum="1DCF9F3240430847" modified="2018-12-05" version="1">MFYYQAYGLTVASEMELPELAIYPEAAAPDVVIQWGQVERRPSSSWYESFDQAFVLSIAGVGYYEVRAGRTIIVESIQPDRRKTRVFLLGSAFGALLFQRGHIPLHGSALAFSNHAYLFTGQSGAGKSTLAHAFTRRGYALISDDVLATELDARGVAHVCSAYPQQKLWPASLEMFGSTGDGLETIWDGESKYRIPVAASFRAGRFPLKKLFRLSASPDIDKPLIREVSGAQKLQIVLDETYRSFFVAEMGLQSAYFRKITQIAQQLHIYELIRPLEGTHPDELVDLVLAQSNNMSKGNDHAIGRINEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQS3</accession>
    <name>A0A398CQS3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyl-accepting transducer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_05760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000026">
        <property type="protein sequence ID" value="RIE04510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04510">
        <property type="protein sequence ID" value="RIE04510"/>
        <property type="gene ID" value="D3H35_05760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="2">
        <location>
            <begin position="2"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="156" mass="16766" checksum="157BEC471D66A688" modified="2018-12-05" version="1">MEASRAESRQGRFAVVAGEVRKLALQSNETAAVISSKVEEIRARNRSSGEADRRGVRRSSERNRAHAPYAQAGGTFQDIVGGIADMEAELREIASAGQEIGARSRSWPLSSKRPTGDIGSECGSFAGSGRHSRIPVEFVCAAWLTRWIADAAHRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRE4</accession>
    <name>A0A398CRE4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_24330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01484">
        <property type="protein sequence ID" value="RIE01484"/>
        <property type="gene ID" value="D3H35_24330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="431"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="464"/>
            <end position="471"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE01484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="674" mass="75583" checksum="19D7CE2EEE6A4604" modified="2018-12-05" version="1">MGTTGKRLFQYALLYKKPIIMALVLLAFAVAVELVGPFLAKRMIDQNILAIEKPWYQTEKDDRFAVSYGGALYKREDHFGKDEERGSEVRILQAGRSYYFAPEARSLPEKAQRTVEGSVMTLKSADGTEVEYAVSKLSLAQTYSFFKPEFRAIAVMAGSYFSCLIVGAALAYGQRYLLQTSANRIIRKMRGDVFAHIQRLPVNYFDNLPAGKVVARVTNDTEAIRELYVAVIANFFSGIIYMTAIEGALFLLDWRLALISLPLLPILYYWIVIYRKFAGKYNHVIRSRLSDINGMINESIQGMPMIQAFRREKETMAEFEVMNDEYYKYQNKLLSLNSITSHNLVNVLRNIIFLIVICLFAKGSFGMAVSVGVLYAFIDYMNRMMNPIVGIVNQLSNLEVARVSAERVFELLDEPGIEVDNGKLARYKGEVRFDDVTFAYKAGEDVLKNISFHALQGQTVALVGHTGSGKSSILNLLFRFYDVERGTITVDGTDIHDIPKQQLRQHMGIVLQDPFLFTGTIASNVSLNDPSISREKVEKALKDVGAYDMFMQLPGGIDEPVIEKGSTLSAGQRQLISFARALAFDPAILILDEATASIDTETEAIIQQALDVLKRGRTTFVIAHRLSTIRAAEQILVLDRGRVVERGDHDRLMAKGGKYYAMYQLQQGSVEVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRG9</accession>
    <name>A0A398CRG9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_11920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EamA transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03378">
        <property type="protein sequence ID" value="RIE03378"/>
        <property type="gene ID" value="D3H35_11920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="149"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="281" mass="30852" checksum="35D9C1887B3A466C" modified="2018-12-05" version="1">MAILAILLVILSGFIHSIWNLFAKKSINKIVFLWYCQWAAVLLFLPLAWIDARTIESLPANGWLLMAASMILHGAYVLLLAKAYTIGDLSQVYPIMRGISPLVVPVIGVLILGENLKMLGWSGIVVILVGIFLGGSFKFKDHREFLSGPIILAFLVGIMITSYTVVDKVTLQYVPAITLNEATNVGNLLILTFMALKSKGLKREWLVNWKTIMLGGILAPGGYILFLKALEILPVSQLAPMREIGTVFGTLMGVFMLRESQGRSRIIASILITIGIVLLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRJ6</accession>
    <name>A0A398CRJ6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c oxidase subunit 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05162">
        <property type="protein sequence ID" value="RIE05162"/>
        <property type="gene ID" value="D3H35_01990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012538">
        <property type="entry name" value="Cyt_c_oxidase_su2a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08113">
        <property type="entry name" value="CoxIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="45" mass="5058" checksum="1EDEC37B1929DC8F" modified="2018-12-05" version="1">MSKDRLPSENREEPSLKGTFVSVLLLAGFIVVTWLAVFFLFVSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRL1</accession>
    <name>A0A398CRL1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Low molecular weight phosphotyrosine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_04775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04790">
        <property type="protein sequence ID" value="RIE04790"/>
        <property type="gene ID" value="D3H35_04775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="4">
        <location>
            <begin position="3"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="158" mass="17794" checksum="7E6BFBDB141AFC14" modified="2018-12-05" version="1">MSYSVLFVCLGNICRSPMAEAVFRDLVVHEKLENVIAIDSAGTGDWHIGKPPHEGTRKTLDLHGISYDGLRARTLATEDGGRFDLIIAMDTRNEQDIRERLGLSARSEIIRFLSLLPERGMDDVPDPYFTGNFDEVYELVKAGCEKLLDRVKSRLAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRS3</accession>
    <name>A0A398CRS3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Efflux RND transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01634">
        <property type="protein sequence ID" value="RIE01634"/>
        <property type="gene ID" value="D3H35_25175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="334" mass="35849" checksum="D0262EF326393334" modified="2018-12-05" version="1">MKQSSDLKDITNNMNEVSPKWVLTLNQQGIDANVSPLLIMQLVGEQLRPVDAGTYTIDNKDRDITLSYDRQITSREELENVQVPTVGGLKKLKDVADITQQNAWIQVNHDDGKMYAQISGTVKKSDEVSAVTKKIEDNINSLSLPSGVEVTIGGGQQMIAEGFVNLGIAMVVAIGLVFLVMSMTFGGLLTPLIILSSLLFIPVGALGALFVTGQSLSMSGMIGMLMLIGIVVTNAVVLLDRVEKNRKSAGMPITEAIVEASKTRLRPILMTAFATMLALVPLALSGSSTSLISGGLAITVIGGLFTSTLLTLIVVPVVYELAWRKRKTKEAETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRY5</accession>
    <name>A0A398CRY5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_03165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04950">
        <property type="protein sequence ID" value="RIE04950"/>
        <property type="gene ID" value="D3H35_03165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="952"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1213" mass="137277" checksum="A53EF7A891E6A4E2" modified="2018-12-05" version="1">MLFHHVFDPGSHAYFEQTSFEIDGYLDVGLFEKSINTLIERYDIFRTVFHYGEGNRLLQMVLRERPIQIQLEDLAEYGIEEQNGVIEQFKQKDKAQGFDLSEGPLMRLALFRKGTAGYTMVWSFHHILMDGWCLSVVAKELFAIYQSLREQKPHGLGPVTPYSQYIKWLGKQDRAAASQYWEGYLEGYELSVTLPTLGNQQSEAYMLEKMSLTLEEDLTRRLTRTANEHQVTVNTWLQTIWGVLLQTYNGVDDAVFGSVVSGRPSEIAGIEQMIGLFINTIPVRIQSRPGMSFSDLVKQVQLLSLSSAQYDYYPLYEIQANSPLKQGLVNHVMVFENYPIEEAIEQSSGQSIGFAISNVETFEQTNYDFSILILPGKKMTIEFSYNAARIDRGMVARIRGHLQEVVAQLVETPHVHIDQLEIVTEEEKRQLLYEFNDTKASYPADQTIHGLFEEQVKKTPDHTAVVLESESLTYAELNGRANQLARVLRGKGVGADRIVGILAERSLEMIVGILGILKAGGAYLPIDPDYPAERIGYMLEDSGADILLTQKRLEAQTMGFAGEVLHVDDERLYALDDTNLEHTGSSKDLAYVIYTSGSTGKPKGVMIEHDNVVRLFFNDRTPFQFSYKDTWTLFHSFCFDFSVWEMYGAILYGGKLIVVPKEVSKNPREFLTLLRTEKVTVLNQTPTYFYQLVEEDRLQAEPLLLRMVIFGGEALKPSLLENWKSKYPNVELINMYGITETTVHVTYKQIKQTEIEGHISNVGQPLPTLHTYILGSDHKLRPVGVPGELCISGAGLARGYLNQPELTAEKFVANPFAPGERMYRTGDLARWLPDGNIEYLGRIDEQVKVRGHRIELGEVESALRSHESVKEATVIARKDEEGSAYLCAYFVANGNLGAAELRKRLSEMLPQYMIPSFFVRVEQMPLTPNGKLDRKALPSPEGTLERGTVYEAPRNALEETLANIWQGVLGVSAIGIADNFFELGGHSLKATTLVSRIHKELNVQVPLREVFQSPTIKELAQAIRGMEAHAYASIEPAPLREYYPVSSAQKRMYILSQLQGADESYNMPGAVMMEGKVDRERFERAFRQLIARHEALRTSFEWVEGEPAQRIHLEVDFEISYKKAEEGGLRQIAEFIRAFDLGQAPLLRVGLLELEPERQVLLYDMHHIISDGVSMDILVREFVGLYGGQTLPARGCNTKIMRYGSRRSCRAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS32</accession>
    <name>A0A398CS32_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxylate-induced protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_10920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03548">
        <property type="protein sequence ID" value="RIE03548"/>
        <property type="gene ID" value="D3H35_10920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026040">
        <property type="entry name" value="HyI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006241">
        <property type="entry name" value="HyI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="2">
        <location>
            <begin position="21"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="248" mass="27607" checksum="09557EDF094B177F" modified="2018-12-05" version="1">MKLSVCVDAVYRGKDFTESVKDVKSAGYDTIEFWTWWDKDLDMVRRAVEEAGVKVATFCTKFVSLVDPLKRGEYIHGLEESIAAAKQLKCGSLISQVGQALAGVSNDEQRQSIVDGLKACAPILERENVTLLVEPLNTKVNHNGYYLSSSAEAFEIVRQVGSPRVKVLYDIYHQQITEGNLIAAIVENIGYIGHFHAAGNPGRHELDVGELNYEYIFKAIKETGFNGYVGLEYFPLDEPSAGLRKLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS91</accession>
    <name>A0A398CS91_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02667">
        <property type="protein sequence ID" value="RIE02667"/>
        <property type="gene ID" value="D3H35_18490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020912">
        <property type="entry name" value="UPF0295"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11023">
        <property type="entry name" value="DUF2614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="124" mass="13257" checksum="EAEC5C36F4B29887" modified="2018-12-05" version="1">MKWKASKISTLRTWALLLTLVGMGLMVFGTGGILLFGGVVGKIIAGIFMVFGMISCFASMAIYFWVGMLSTSAPVLDCPECGKRTKMLGTTDRCMYCHTILTVDPTHAPTLGDDERTAAAPAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSL3</accession>
    <name>A0A398CSL3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PhoH family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_06380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04239">
        <property type="protein sequence ID" value="RIE04239"/>
        <property type="gene ID" value="D3H35_06380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="3">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="443" mass="49904" checksum="6647D3575718445C" modified="2018-12-05" version="1">MRKIYVLDTNVLLHDPHSMFAFDDNEVIIPSVVLEEIDSKKRLADEIGRNARYVSRELDRMRSLGHLHQGVDLPNGGILKVEMNHRAFVRVQEQFGEMSNDNRILAVGLNYYLEQSEEDEPRPVIIVSKDVLVRVKADVLGIIAEDYMTDRTASPSDQYTGHLTLHVHPSVIDEFYTYRFLGVSQLGLKGKLHPNEFVILRDELGTSKSALLKVSSDGHRLEPLHMSNDPVWGITARNAQQRMALELLLNDEIPLVTLTGRAGTGKTLITLAAGLMKVEDEHKYKKLLIARPVVPMGKDIGYLPGEKEEKLRPWMQPIYDNLEFLFDTKKSGDLDKILMGLGSIQVEALTYIRGRSIPGQFIIIDEAQNLSMHEVKTIVSRVGENSKIVLLGDPEQIDHPYLDAQSNGLTYLVERFKEEGISGHVTLEKGERSKLAQLAAEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSP3</accession>
    <name>A0A398CSP3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sigma-E processing peptidase SpoIIGA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04269">
        <property type="protein sequence ID" value="RIE04269"/>
        <property type="gene ID" value="D3H35_06540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030436">
        <property type="term" value="P:asexual sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005081">
        <property type="entry name" value="SpoIIGA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03419">
        <property type="entry name" value="Peptidase_U4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="312" mass="34535" checksum="1D6BB8C8846563B8" modified="2018-12-05" version="1">MRLFFAQRTKKARAARQKNRGKGGTIRQTPNIKAIILGSSIPAWRRRRLARPVKGGGVELVVYVDIVFFNNLAIDGTVLLTTAKVLRLRPSKLRLFGSAVVGGAYAAAMFLADVPYLYSFAAKVAVSLLMVLLAFGYGGPLRMARHFGAFYTVNFATLGGVVGLSFLFRSSRSPWEGMSFTSDGGLLLNWKAMQLAMLVCSIAMSVWLFRKTGESRSKRETLATLLWDVSVRVDDEAWTVRALLDTGNRLYDPLTRIPVMIMEASVWKELLPEGWGERLKGESADRLIAEMNDKPTEPFAWAIGCASFLIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSS6</accession>
    <name>A0A398CSS6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stage II sporulation protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">spoIID</name>
        <name evidence="4" type="ORF">D3H35_14710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02014">
        <property type="protein sequence ID" value="RIE02014"/>
        <property type="gene ID" value="D3H35_14710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013486">
        <property type="entry name" value="SpoIID/LytB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013693">
        <property type="entry name" value="SpoIID/LytB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014225">
        <property type="entry name" value="Spore_II_D_firmicutes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30032:SF4">
        <property type="entry name" value="PTHR30032:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08486">
        <property type="entry name" value="SpoIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02669">
        <property type="entry name" value="SpoIID_LytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02870">
        <property type="entry name" value="spore_II_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="SpoIID" evidence="3">
        <location>
            <begin position="131"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="416" mass="45191" checksum="F66349CA0E841095" modified="2018-12-05" version="1">MIRSWKIEWAAFAGGTLAAGILWLFVHAPGFEGQLSTTIGNESPKSEAQSQVQSQAQSQVQSQAKRLSDGPASERLQGGSPSSENPDPGKSDSVSGSLPVTQGLSPLTQGLTPLEPNSRYPEPFVRVYLSESKTVETVSLETYVRGVVAAEMPLDFEPAALEAQALAARTYILRRLMNDDRTGMPVQNADVTDTQTHQAYRSISRMSKLLVQDREGWMKADQACRNTRGLIIAYEGQPIDALYFSTSNGYTENSEDVFPFKLPYLRSVESPWDKEGAPRSKETVEMPLKRFYELLGAKSAQAMGPIVAGAGGGKLPIRVTERSEGQRVKMLAVGTLKLPGTEVRSMLGLRSSSFEWVIKGSKIFITTYGSGHGVGMSQWGAEGMAKAGSTSREIVEHYYPGVNLMEVSKLPNGSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT26</accession>
    <name>A0A398CT26_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_17380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02471">
        <property type="protein sequence ID" value="RIE02471"/>
        <property type="gene ID" value="D3H35_17380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="146"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="365" mass="39709" checksum="01A9E88D3D52D792" modified="2018-12-05" version="1">MKNGKLQIGFIGCGGIAHQKHFPSLQQLGQLCDLVAFCDIVEERAVQSAAKYGTPDAKAYTDYLAMLTDESLDVVHILTPNVMHGEMTVAALEHGKHVMCEKPMAHTSADALKMIEAARKSGKKLTIGYQNRFREDAIIAHKASSAGELGEIYFAKAHAVRRRAVPTWGVFTDKKLQGGGPLIDIGTHALDLALWIMDNYKPVSVTGSAFYKLKDKFEGNMFGPWNPATFDVEDSAFGFIKMDNGATIYLESSWALNTTDTREASVTLCGTEGGAEMSGRASGGIQLTFNSAKHGSLFDESPQLQGGIAYFNGAKETDGTREARHWLEAILNDSELIVKPEQALVVTQILEAIYESARTGETVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT74</accession>
    <name>A0A398CT74_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05360">
        <property type="protein sequence ID" value="RIE05360"/>
        <property type="gene ID" value="D3H35_00810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="40"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="324" mass="36864" checksum="7F2149D529415A6A" modified="2018-12-05" version="1">MQTVSTAHPMDELKNRLRLILNVLPPGSDIYYIDYPVHGNGGDLLIMKGTEAFFKENRIRVRARFSVLDFPDGLAVPKDHILVLHGGGNFGDLYPAHQKLREKVVADYPGNRVVMLPQTIFYKDVREFERTAAILNRHPDVHLYVRDTLSLDMARDKFGRCGVYLSPDMAHQLWPIRGRTDPDKELLRFLRTDIEKTAGQDRLEASGTGDCLDWSTLYSRTEQRTIRVFSGVLRKGKGKLPVGQIWSRYTDRLVKKAVDRFGHYRTVQTSRLHGHILSCLMDKPNVLIDNAYGKNASYFRTWTQGIASARLLAEPANKQSGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT76</accession>
    <name>A0A398CT76_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02164">
        <property type="protein sequence ID" value="RIE02164"/>
        <property type="gene ID" value="D3H35_15565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="90" mass="10033" checksum="AEDE4EE351F786AC" modified="2018-12-05" version="1">MARFGRASSDVWDEVPPLARFGRASSDVWDEVPLLARFGRTSGDVWDEVPPLARFGRTSGDVWDEVPLLARFGRASSDVWDEVPPLARFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTJ6</accession>
    <name>A0A398CTJ6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable queuosine precursor transporter</fullName>
            <shortName evidence="1">Q precursor transporter</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02284">
        <property type="protein sequence ID" value="RIE02284"/>
        <property type="gene ID" value="D3H35_16290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990397">
        <property type="term" value="P:queuosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02088">
        <property type="entry name" value="Q_prec_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003744">
        <property type="entry name" value="YhhQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34300">
        <property type="entry name" value="PTHR34300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02592">
        <property type="entry name" value="Vut_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00697">
        <property type="entry name" value="TIGR00697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="238" mass="26699" checksum="BFF9B1A858DCAA7D" modified="2018-12-05" version="1">MYNFGWGALFVLVNFALFLACYRLFGKNGLYAWIGAAVVLANIQVVKTIEMFGLVMTLGNTIYGTIYLTTDLINEKYGQKEAKKAVWFGFFILIMSTVIMQMALKFTPAESDFAQGSLETIFGLMPRIALGSLAAYAVSQTLDVQVFSRLKRKYPERNKLWLRLNGSIGLSQLVDTLVFCTIAFAGAEGYPWDVWWQIALTTYLIKFVISVACTPVIYIARSFRFEDESKVEGLSSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTZ1</accession>
    <name>A0A398CTZ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04739">
        <property type="protein sequence ID" value="RIE04739"/>
        <property type="gene ID" value="D3H35_04450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="249" mass="25977" checksum="943FE55A7175DB3E" modified="2018-12-05" version="1">MNLQGKVAFVSGGARGIGAAAALLLAERGARVAVNYIQQEDSAQAIVDLIRSAGGTAELARADVRDPDQVHSAISHIQSTLGGIDILVSNANMSFVMKPLLAMPWEEFAQKLNDEMKATFTLTQAALPAMIAQKYGRIIYISSNAADVALPYFAAHGSAKAALNAFAKYVALESAPYGVTANVVSPGLVQTDASSSTPESVKQQIAAMTPLQRVAVPDDVSGAIAFLASEESRFLTGTCTYVNGGLLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU76</accession>
    <name>A0A398CU76_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04819">
        <property type="protein sequence ID" value="RIE04819"/>
        <property type="gene ID" value="D3H35_04945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="256" mass="25431" checksum="8CE8095AB7D223C9" modified="2018-12-05" version="1">MWSRAQQWYEVPYNRLEVVFECATVVRGTVQSAESAVERVTVGRGTIQSAESAVENATVGRGTIHSVGCAVESATVGRGTIQSAVSAVENATVGRGTIQSAGSAVESAAVGRGTILSAGSAVESAAVGRGTVQSAESAVESATVGRGTIQSAEGAVENATVGRGTILSAEGAVESAAVGRGTILSAGSAVESAAVGRGTVQSAESAVERVTVGRGTIQSAKSVVESATMGRGTIQSAGSAVESATEGLSQKVIKWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU83</accession>
    <name>A0A398CU83_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hpt domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_05015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04829">
        <property type="protein sequence ID" value="RIE04829"/>
        <property type="gene ID" value="D3H35_05015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="2">
        <location>
            <begin position="38"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="150" mass="16737" checksum="989F51129FE55D8F" modified="2018-12-05" version="1">MAATAFVRAAANSCWNGVAPPDVPGLDARTALRRLDGKWPLYVKLLHTFREQYADCAERLRKQLEASDYAGSVKLLHSLRGAAGHLGAFELQHTATLLEQAVEEHPNEPDAALLRLFEDQLNTLVCSIQELPLEIEFDKKDVRRTQSDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUL7</accession>
    <name>A0A398CUL7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3891 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_20480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02981">
        <property type="protein sequence ID" value="RIE02981"/>
        <property type="gene ID" value="D3H35_20480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024992">
        <property type="entry name" value="DUF3891"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13030">
        <property type="entry name" value="DUF3891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="261" mass="29815" checksum="3079D6AE3F887959" modified="2018-12-05" version="1">MIAYNREHDFVMVKQHDHGQLAGELAKRLQPEIVGSNDRLEDFRLAVSEHDSGWMDLDEVPLWNDVGNKPFGVEDLPLLLRLPFYRRALEKIAETSEYAALLVSMHYTTFQPGVLSHMVGGFHERALPYLERLKREQLEIRARLELMEGDRARLLEHHLNLLQLCDELSLYLCFQDPGTPKDKELLPYKDGFQRSVSFLDGVKLSAEWTEPGHLKLTPFPLCKPVQLTYAAKYVSKDRIGDIGLAAAYSEAPLQIRAFTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUM5</accession>
    <name>A0A398CUM5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02694">
        <property type="protein sequence ID" value="RIE02694"/>
        <property type="gene ID" value="D3H35_18740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="SSF50985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="79" mass="8726" checksum="7E1B02E91B1113BE" modified="2018-12-05" version="1">MQTSILTDVVAIAKGSRHNIALRSDGTVWTWGFNLSGQLGDGKRVDQYVPTQVTGLSLKVPVLTLDSMILRWQKKARNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUV2</accession>
    <name>A0A398CUV2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl-CoA_dh_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05039">
        <property type="protein sequence ID" value="RIE05039"/>
        <property type="gene ID" value="D3H35_02570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="100" mass="11117" checksum="71A7CA65BD72D9A5" modified="2018-12-05" version="1">MSAKLAASRQLVLHAARLLQAYQETPELLPSVRAAASHAKIIATETALEVTSGIFQTMGARAATRENNFDMYYRNARTLTLHDPVDKHRETVGRLQLVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUW8</accession>
    <name>A0A398CUW8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05059">
        <property type="protein sequence ID" value="RIE05059"/>
        <property type="gene ID" value="D3H35_02710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017260688" evidence="1">
        <location>
            <begin position="24"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="133" mass="14766" checksum="4D66F48F4C26B477" modified="2018-12-05" version="1">MKKMVSFMLVSALLLSFSGMVFATQETKNNGILTSDVDLTKERTEKNKIKINNIKKDPDFEIVYDDGQGNASFVPSNAAQGKSDKQRIKAKLESFSTQYSYSTVNSGLKNLSYSDGQVTSQFYSDINNSNGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVB7</accession>
    <name>A0A398CVB7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Excinuclease ABC subunit UvrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D3H35_01580</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05239">
        <property type="protein sequence ID" value="RIE05239"/>
        <property type="gene ID" value="D3H35_01580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="4"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="448"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="488"/>
            <end position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE05239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="751" mass="81931" checksum="4F90B71361F7A808" modified="2018-12-05" version="1">MSESNQEYIVISGARENNLKNVSLRIPKRKITIFTGVSGSGKSSIVFDTIAAESTRLLNENFSMFVRNFLPRVPQPDTDAIENLSMAVIVDQKRLGGGSHSTMGTITDISPILRLLFSRVGQPYVGQANMFSFNDPQGMCPECNGIGRRLGVDMSKALDKSKSLNEGAILLPGYTVNGWDWNMIVQTGFFDPDKTLSDYSDEELEQLLYGKARKVETQFAGKAVNITVEGIIEKFTNKYIKQDVKTKSERTQQAVAPYISEGPCTSCRGARLSKAALGCRINGHNIAELSSMEVGQLIRVIREIDDAIAAPVVKSLTERLQHLVDIGLDYLTLDRETDTLSGGESQRVKMVKHLSGSLVDVTYIFDEPSVGLHPRDVHRLNELLQKLRDKGNTVIVVEHDPDVIKVADHIVDVGPHAGSRGGTIMYEGSFQGLLEAGTLTGTHLKRPLQLKHDFRQPSGKLSIKDATLHNLRNVSVDIPTGVLTVVTGVAGSGKSTLINEVFLGQHPDAIVIDQSAVGVSTRSNPATYTGIMDDVRKAFSSANKVNQGLFSFNSKGACENCQGLGVVYTDLAFLDSVKLPCEVCGGKRFKEEVLTYKLNGKSIAEVLEMTVEQALDFFQLKEVVRKLQAMSDVGLNYITLGQPLSTLSGGECQRIKLASELHKKGSIYVMDEPTTGLHMSDIGHLLEIMNRLVDAGNTVIVIEHNLDVISQADWLIDMGPDGGSKGGQVVFEGTPPQIVHAERSITGKYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVI3</accession>
    <name>A0A398CVI3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_00040</name>
        <name evidence="4" type="ORF">D3H35_00085</name>
        <name evidence="2" type="ORF">D3H35_01230</name>
        <name evidence="1" type="ORF">D3H35_08945</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000011">
        <property type="protein sequence ID" value="RIE05319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000001">
        <property type="protein sequence ID" value="RIE05485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000001">
        <property type="protein sequence ID" value="RIE05488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04064">
        <property type="protein sequence ID" value="RIE04064"/>
        <property type="gene ID" value="D3H35_08945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05319">
        <property type="protein sequence ID" value="RIE05319"/>
        <property type="gene ID" value="D3H35_01230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05485">
        <property type="protein sequence ID" value="RIE05485"/>
        <property type="gene ID" value="D3H35_00040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05488">
        <property type="protein sequence ID" value="RIE05488"/>
        <property type="gene ID" value="D3H35_00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014967">
        <property type="entry name" value="Uncharacterised_YugN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036491">
        <property type="entry name" value="YugN-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08868">
        <property type="entry name" value="YugN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160755">
        <property type="entry name" value="SSF160755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="137" mass="15144" checksum="91CFD2C77D943757" modified="2018-12-05" version="1">MHSLASSLTSRQLEFVPVQDALAEKGFALGGGWEYDHGSFDCALDEANTVFLRIPFDVEVGRLDSETANNEAQIRFGQPFVLRHLYNEGLDSEAQARTLGALFDQFSDPVDPDASIEPAWVEAAGRKLREVETIFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWU6</accession>
    <name>A0A398CWU6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_12610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03484">
        <property type="protein sequence ID" value="RIE03484"/>
        <property type="gene ID" value="D3H35_12610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="259"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="405" mass="45733" checksum="AC78683357467796" modified="2018-12-05" version="1">MNVNRIPVTVLSGYLGSGKTTVLNHVLNNRQGLKVAVIVNDLSEVNIDAALVKEGGGLSRTDEKLVEMSNGCICCTLREDLLREVERLANEGRFDYILIESTGVGEPVPVAQTFTYVDEEQGIDLSRICRLDCMVTVVDAYRFWHDFSSGESLLERNQAVGEDDTREVVDLLIDQIEFCDVLLLNKCDLIDEEELAQLEGVLRKLQPRAKIVRTVRGKVDPADLLNTGLFDFDEASQSAGWIRELEKPTHTPETEEYGISSFVYERIKPFHPGRLMEWLEEWPVEIVRAKGTMWVASRNDMGQSLSQAGPSIQFGPSGYWVAALPQEERELYLQEDPELVGIWSPEFGDRINKVVFIGIEMDRERIAASLDDCLLDDAEMKMDWTEFIDELPNVYEETGFAESVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWY8</accession>
    <name>A0A398CWY8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">crcB</name>
        <name evidence="10" type="ORF">D3H35_07040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04347">
        <property type="protein sequence ID" value="RIE04347"/>
        <property type="gene ID" value="D3H35_07040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="160" mass="16514" checksum="AB41248847704B85" modified="2018-12-05" version="1">MTLSRWPPLTPSLARLSAGCWPGRDFGSEREGGLLLNGWTIALVGAGGAIGALARYGVGRLVVRAGQKAVWGTLAVNLIGTFAAGMFFGMHLGARSPVVYAFAVPGLLGGLTTYSTLNVQKAQLAREGRGKLLLRYASATYVGGWACAATGAALGTLLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX66</accession>
    <name>A0A398CX66_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_02020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05168">
        <property type="protein sequence ID" value="RIE05168"/>
        <property type="gene ID" value="D3H35_02020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="PTHR12918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="195" mass="22339" checksum="993574495190B34B" modified="2018-12-05" version="1">MGERYDWKRLESSIAGIVSEETDYRAIIDKVRPLLQELLTDDQLLPEHYRKPLPNKYAQYLLYRPENEAFSVIAFVWGPGQTAPVHDHLVWGLVGIYRGSVIEKRYRRFDVGEDGQPQYAIKEIAEVRADQGDITFVYPPDHDIHGVSNPFDEIAVTVHIYGTDIGKQLRHIHDVATGQSRDVVTRHDNEAPVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXH2</accession>
    <name>A0A398CXH2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">trmB</name>
        <name evidence="2" type="ORF">D3H35_10315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03684">
        <property type="protein sequence ID" value="RIE03684"/>
        <property type="gene ID" value="D3H35_10315"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="199"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="254" mass="29654" checksum="98503F189697060F" modified="2018-12-05" version="1">MRLRGRKNIRESLERQPDLVVLEPQKLKGRWHEYFGNDHPIHIELGMGKGQFISTMSGTNEQINYIGMDIFDELIRRGSEKARKVWREKGSEEVPNLALVRGNVEQLELMFEPGELARIYLNFSDPWPKSKHAKRRLTHPRFLLKYKEALDEYGEIHFKTDSLSLFEFSLNSFSDTGLQMKNISLDLHRDGIRHDLVLTEYETKFSGQGMPIYRLEAAIGDRIVAEHRARIAEEFAEQARRAEAREQTLDIENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXQ1</accession>
    <name>A0A398CXQ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_09415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03764">
        <property type="protein sequence ID" value="RIE03764"/>
        <property type="gene ID" value="D3H35_09415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017416843" evidence="2">
        <location>
            <begin position="30"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="147" mass="16357" checksum="1D1EA6E47077B92C" modified="2018-12-05" version="1">MRKKLLVVTVLMSLIVGVVFSSFAGTAEAEETVGTETGTGSQQAPIPQPTIPESPITEVRENVAVESTSVKIIKVEQLEGYLSFGDVLTIRKQNSSEFAYNYMSDRDDHQWKVPVQDVDRSAIYDVVMATTFIEIDTGKYFSIMIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXS7</accession>
    <name>A0A398CXS7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Riboflavin biosynthesis protein RibD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Diaminohydroxyphosphoribosylaminopyrimidine deaminase</fullName>
                <shortName evidence="10">DRAP deaminase</shortName>
                <ecNumber evidence="10">3.5.4.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Riboflavin-specific deaminase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">5-amino-6-(5-phosphoribosylamino)uracil reductase</fullName>
                <ecNumber evidence="10">1.1.1.193</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">HTP reductase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">ribD</name>
        <name evidence="15" type="ORF">D3H35_03635</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17845"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58421"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="EC" id="1.1.1.193"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 13">Binds 1 zinc ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">In the C-terminal section; belongs to the HTP reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.26" evidence="10"/>
    <dbReference type="EC" id="1.1.1.193" evidence="10"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04597">
        <property type="protein sequence ID" value="RIE04597"/>
        <property type="gene ID" value="D3H35_03635"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004794">
        <property type="entry name" value="Eubact_RibD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011549">
        <property type="entry name" value="RibD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006769">
        <property type="entry name" value="RibD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00326">
        <property type="entry name" value="eubact_ribD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00227">
        <property type="entry name" value="ribD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 12" id="KW-0521">NADP</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="8 10 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="297"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE04597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="375" mass="39854" checksum="F17EEAA93782FA5D" modified="2018-12-05" version="1">MELLNDEYYMRLALQLANGASGQTGVNPVVGCVVVKDGRILGMGAHLKRGEAHAEVHALNMAGKDAEGATAYVTLEPCSHHGRTPPCCDRLIAEKVARVVVATTDPNRLVAGQGIERLRANGIEVTVGLLQDEARLQNEKFNHHIVTGLPFVTLKTALTLDGRIATRTGHSRWITGPEAREAVHTLRHRNQGIMVGIGTVLADDPELTTRLTVPGVHPVRIVVDSSLRIPPGARVLNDASPTILLTTERADPAKERACIQNPGVTVIRCGDGPSVDLKLAVSELGKREIGSILLEGGGALNGAMLQAGLVNKLMLFYAAKIVGGEGSPSAFAFEGPAEMSSALELERIAIERYGDDWCVTGYPKPSANKATDDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXU9</accession>
    <name>A0A398CXU9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_03745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04617">
        <property type="protein sequence ID" value="RIE04617"/>
        <property type="gene ID" value="D3H35_03745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017214656" evidence="2">
        <location>
            <begin position="29"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="101"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="294" mass="31643" checksum="3FD243AB5BB939CB" modified="2018-12-05" version="1">MTRTLLAVSAAALALALAACSQGDNANAPAASPSSAASPSATPSTSAEPGPSPGSTVSAEPSAPASESPSSSPSEAQPALVYKMNKVYSIVPIDKAKTNAKVVLLTFDDGPKDKETLDPLLDALDKHQAKAIFFVNGYRAKAKPELLKEIDERGQTIGNHSWDHIKLGKEKPDKIRKQIEDVQKLVREITGKTPVFFRPPHASANSDVHAIAKENGLLFMTWSNGSLDWDMAKIKEDKRPQAIVDNVLEQLRNGSNILMHELPWTAKGLDRLLTELEAKGYSFVDPAAIDVKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYW3</accession>
    <name>A0A398CYW3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_07500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04421">
        <property type="protein sequence ID" value="RIE04421"/>
        <property type="gene ID" value="D3H35_07500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="259" mass="28467" checksum="997B07D7D5852523" modified="2018-12-05" version="1">MKAALELHSLSKAYRRSDGRSHPVLDGVSLTVGEGEFVSLVGPSGSGKTTLFRLIGGVEKPDAGRIAIGDREVTGERGHISYMPQQPALFPWLTVTGNIAAALETGGMDRKMARKAGLEWLRRIGLEGVAEEYPHVLSGGMQQRVSFLRALLMPRNVMCLDEPFAALDALTRADMQRWLLQLWEAERRSVLFVTHSIEEALTLSDRIYVLSAAPAKVVKEIVVPFDRPRRPDVWLAPAFVELKKEVLDLLGQGDGSNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ96</accession>
    <name>A0A398CZ96_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell division protein FtsL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ftsL</name>
        <name evidence="8" type="ORF">D3H35_06455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential cell division protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <text evidence="6">Localizes to the division septum where it forms a ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FtsL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04254">
        <property type="protein sequence ID" value="RIE04254"/>
        <property type="gene ID" value="D3H35_06455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00910">
        <property type="entry name" value="FtsL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011922">
        <property type="entry name" value="Cell_div_FtsL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02209">
        <property type="entry name" value="ftsL_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="145" mass="16528" checksum="D75009EAC3C1430C" modified="2018-12-05" version="1">MRNKRGDKDKMAYYGNLALRPERAPEETVKPVRETYKVVKKRQLPIGEKLLYLLTVAVLVIVACVILNRYAQIYEMNRTIQQQKAQVEQLTTQTKELQREVERLSDPERISDFASKQLGMVKLDQQGITIAANNGRTAIAAKPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZK9</accession>
    <name>A0A398CZK9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000013">
        <property type="protein sequence ID" value="RIE05297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05297">
        <property type="protein sequence ID" value="RIE05297"/>
        <property type="gene ID" value="D3H35_01345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="257" mass="29008" checksum="08B54895324C9550" modified="2018-12-05" version="1">MSRWIDLTGKLEDGMWNYGAPFPEVVIEKVADAALFGYEGHAFQLHSLAGTYLETANHLFPDRERLGDVSIDRLKTRAWVAQLPNKRPFESIGAAELEEAVGSVLEPGDALLIATGWDAYWNREGFTESSPYFEPEAMEWIIARDVGLLGMDITSIEDPRKPGGEMTLLARYYAKDRLMVAPLVNLREAGRGPWTLLALRCTFPMRAPPLRAVLFEPDCKGQGWVCSQACWRQPALWRGAARRIRRRRGWGARCSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZR1</accession>
    <name>A0A398CZR1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ackA</name>
        <name evidence="8" type="ORF">D3H35_04180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04691">
        <property type="protein sequence ID" value="RIE04691"/>
        <property type="gene ID" value="D3H35_04180"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="208"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="283"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="331"/>
            <end position="335"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="402" mass="44545" checksum="FF945996091EBF34" modified="2018-12-05" version="1">MNVLVINAGSSSLKYQLYNMVTEEVLSKGRVERIGMDSSILTHEVDEKPEVREVSEILDHTTAIRKVLDMLTHREFGVLRNIKEIRAVGHRVVHGGESFSESVLVDKDVKLEIRQLFDLAPLHNPAHMMGIMAVETNLPDVPQVVVFDTAFHQTMPKNSYLYAIPTVLYRKHKIRRYGFHGTSCDYVSKRAAEFLGRPIKELNLIVCHIGNGASCTAVLGGKSFDTSMGMTPLEGLMMGTRSGDLDPAIVPYTLNKEELTLNEVNSMLNKHSGLLAVSGISSDMREVVQAMKEGNEQAKLAFEMYAYRIRKYIGAYAAAMNGVDAVIFTAGVGENSDVLRQAVCEGLTFFGIGLDHERNAVRSGEPRRISTDDSKVEVLVVPTNEELLIARDTYRLVLGEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D076</accession>
    <name>A0A398D076_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_05250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04871">
        <property type="protein sequence ID" value="RIE04871"/>
        <property type="gene ID" value="D3H35_05250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="253" mass="28831" checksum="D26206192551A7E0" modified="2018-12-05" version="1">MSDAYVLSVANKYRINSVIDPNIQTKVINPLNRIIIQWAGSCLNNVYLSGSRLKGTAITLSSDFDLFISLKSDTDNTLKEIYESLSFSLEQAGLETRRQNVSLGINVGGNQVDLVPAKKRSGNTNYHSLYISKRNTWTQTNVVEHANIVRVSGRSTEIVLLKIWRKLHGLSFPSIYLELTVIKALKGVSRNDPANNFWILLQYLRDEFVDLIIIDPCNSANIISDDLYKYEKEAIRKQARDSLSQKYWKDIIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1Q3</accession>
    <name>A0A398D1Q3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000005">
        <property type="protein sequence ID" value="RIE05431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05431">
        <property type="protein sequence ID" value="RIE05431"/>
        <property type="gene ID" value="D3H35_00425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="404" mass="44815" checksum="34001F619299DD92" modified="2018-12-05" version="1">MKWTFLDPNGTSAREVALKQIITNFERDNPNVKVAVEPQVWDTLGTKFLAANQTGNAPDVIWTSMDDFGTALKQNALVDFESLFLNSWTPEDIKDIDDAYWAFGNKDGKHYQVTLSRNYIGILYREDLLAEKGIKVPFKTWDELIDAAVKLTEKDAATGIQRYGFGQAFSPESPDPQVFPPSLIQSQGDMFTEGGKANWSTDAGVTAMNRQLDMVTKYKVTPDSAISSSVEDVYNEFKAGRYAMMIGAGVRIPTLQKESTFDGSKIQMTYFPSEDGSTFSPSVINGWNVGVWSGSKNKEAAGKFVEHMINAESDEIWMTVGGQVPVRKSTVQKNADFLSKPDKTYLSVMAEGFAKYGYAQPWEFPVSGWRADLNKIAQDILVKGKDVKAALQAAEKEFNERAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D2M4</accession>
    <name>A0A398D2M4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylglycerophosphatase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_01065</name>
        <name evidence="4" type="ORF">D3H35_01080</name>
        <name evidence="2" type="ORF">D3H35_08090</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000009">
        <property type="protein sequence ID" value="RIE05324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000009">
        <property type="protein sequence ID" value="RIE05327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03916">
        <property type="protein sequence ID" value="RIE03916"/>
        <property type="gene ID" value="D3H35_08090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05324">
        <property type="protein sequence ID" value="RIE05324"/>
        <property type="gene ID" value="D3H35_01065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05327">
        <property type="protein sequence ID" value="RIE05327"/>
        <property type="gene ID" value="D3H35_01080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06971">
        <property type="entry name" value="PgpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036681">
        <property type="entry name" value="PgpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026038">
        <property type="entry name" value="Put_PGPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007686">
        <property type="entry name" value="YutG/PgpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04608">
        <property type="entry name" value="PgpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019587">
        <property type="entry name" value="PGPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101307">
        <property type="entry name" value="SSF101307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PgpA" evidence="1">
        <location>
            <begin position="26"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="183" mass="20262" checksum="92EAC06C6D9F19C5" modified="2018-12-05" version="1">MSEPNVYRLNSKIVATATEEWLTKRGVTKEQIGQLVMLLQKDYFPELTLDECVRNVDAVLGKREVQNAVLTGIQLDILAEEGKLLPPLQAMIQHDEGLYGCDEVLALSIVNVYGSIGFTNFGYIDKFKPGVLKKLNDKNSNEIHTFLDDIVGAIAAAASSRIAHRKQAEREAETEALEESENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBX0</accession>
    <name>A0A398CBX0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_27215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00656">
        <property type="protein sequence ID" value="RIE00656"/>
        <property type="gene ID" value="D3H35_27215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005690">
        <property type="entry name" value="GerBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="509" mass="56381" checksum="9B6ADA9B06143ECF" modified="2018-12-05" version="1">MRKKTSLPPFTDSQPDAHSNAPVQTLSETLDDNEAVIRSVFDRCSDLIVRRLQLPGSVSCMAVYLSVLIDDDKWSSGLLQPLMNLDTDRLEDRSKLLEWLRDRMDSTYQPQTAETISEIARSIVGGGVALFFESYSLALTVMIPNQLHRALEEPKTEAVIRGPRVGFIEKIEINLTLLRQQIQSPQLKIERMSVGTVTRTEVAVVYLDKLAPSDVVEVVKKRLSKIPMTSVLGTGYIEEMISDHPYSPFPIINTTERPDSASGSLMEGKVAVLVNGTPLVMIMPVTFWFGFQSTEDYYMNFIFATMLRWLRYLFAFFAIAAPSIYVAITTFHQEVIPTSLALSLATAREIVPFPTMVETLIMEVTFEALREAGVRLPRAVGQTISIVGALVIGQAAVQAGIISAPIIIVVSLTGIASFLIPQPAMSQAISILRFPMVICAGTFGLYGVSGCIIALLIHLANLHSFGFPYLWPVAPFNRAGIMDVLFRAPWGIMQKRRQLVQQDPEAQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CC12</accession>
    <name>A0A398CC12_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00696">
        <property type="protein sequence ID" value="RIE00696"/>
        <property type="gene ID" value="D3H35_26210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="178" mass="20498" checksum="4C710BD70CDF7B99" modified="2018-12-05" version="1">MLRHASRPTRIPGSQLIRDRRTVRQFREDPVPQLLITKLLDIACWAPNHGFREPWRFIQYRGEARRTFAESVVATFSAEEKEKNGDRRLAYYMDIPVHLIVVAKEDPRAKQREEDFAAVCCWIQNFQLAAGKEGSASSGKRIPICTLRLSGDGRRPRGERIAPCCTSDIRRHSDARPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCP3</accession>
    <name>A0A398CCP3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00175">
        <property type="protein sequence ID" value="RIE00175"/>
        <property type="gene ID" value="D3H35_29475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="81" mass="8925" checksum="6112BB28D5F0EF87" modified="2018-12-05" version="1">MFDKQSKAVFAYSSEIVTALTRLIEQGQAAGELLPGDPEATGWSYFSYVSGLGMINHDADDNLVREFVDRGCRIIGLLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDZ0</accession>
    <name>A0A398CDZ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ger(X)C family spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_27210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKC lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00655">
        <property type="protein sequence ID" value="RIE00655"/>
        <property type="gene ID" value="D3H35_27210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008844">
        <property type="entry name" value="Spore_GerAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038501">
        <property type="entry name" value="Spore_GerAC_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35789">
        <property type="entry name" value="PTHR35789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05504">
        <property type="entry name" value="Spore_GerAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02887">
        <property type="entry name" value="spore_ger_x_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="432" mass="47580" checksum="1A5830B26EAC64EC" modified="2018-12-05" version="1">MACRSVQPGRHYGCPVPGSMGNHAKAAAARPAGSGGAKSMRAGWKPFIIAISTVCLCLLSGCWDRKEMDELALVMASGVDLAEDGQIEVTLQIAIPTGIPGTLQSGGKEKKPVEVISAKGEAGFEIIGKLQQQLSRRLFFGHRAVFVVGETYARNSIDQTLDVLIRLPDSRHNCYILTTQGTTAKEVLTSPYHMEFIPAIGMKNIQSGDFSVGVKIDEFMADLSIEGKMPVTGAISLIRSGNENTFQIDQAAIYRDTMLVGYLSGAELKAYKMIMDGAHNLMVTVKVESQHAKTKGTVSAEILKGGSRVRTFWRNGMPQIEVFYHATARITNNDSTLDLSKSNNLLRAESELSDEVQNAIERMIDKLQHEFKADALGFGTLFHQQHPQVWKQLKSQWNDRYPEARVDVKARIRIERMGRTEAPGPLESEEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEJ7</accession>
    <name>A0A398CEJ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ger(X)C family spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_22225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKC lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01133">
        <property type="protein sequence ID" value="RIE01133"/>
        <property type="gene ID" value="D3H35_22225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008844">
        <property type="entry name" value="Spore_GerAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038501">
        <property type="entry name" value="Spore_GerAC_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35789">
        <property type="entry name" value="PTHR35789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05504">
        <property type="entry name" value="Spore_GerAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02887">
        <property type="entry name" value="spore_ger_x_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="399" mass="43933" checksum="911FE4FD34CDF040" modified="2018-12-05" version="1">MKATVYLLGCLSLISLLLAGCWDKNELTDWGFVQAVAIDRSESGRIKVMAQIYRPGSSESRSGMATKGGSYLSLTEEAATMSEASLKLAAELGRRLQWSHMRALLVGEQVIRTRNIGELLDFFSRSQGPRGSVNVMTTQGEASRYLLIKPLIENTIGQQLRTAESIASTQAGISTTITLLDLNILSQTPGSIALLPHIRLSKDEHEVVTIDSLAILRFPEGTIDASLVPMQFAPYLLMIRGEYRRGQLSIPCEKEEGKGSSGVTKEDSYWVYASKSRLKVTQRGGRPLIRIHLDLDGKMGEMTCSDIQTVDGNAHFLKRVAEEIERGAKDAVDFVQEKKADVLLAGQYLERRNPRLWRSWSGDWAEQFSYAKVIVTVSARITDTGMNAGNPFTAVSGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFG6</accession>
    <name>A0A398CFG6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA_27 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_27135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00642">
        <property type="protein sequence ID" value="RIE00642"/>
        <property type="gene ID" value="D3H35_27135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038734">
        <property type="entry name" value="YhaN_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13514">
        <property type="entry name" value="AAA_27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_27" evidence="3">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="637"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="713"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="766" mass="85447" checksum="5E348957D6A12AD3" modified="2018-12-05" version="1">MQIRELQVDGYGALHGISCAFDAPVTVLYGPNEAGKSTLLRFIRSMLYGFPTRKEPVERGEPVGGGRHGGRLLLLSSSGRELTLERHSDGSTGNGGRKNGTSGFAIRDGSGVFLPISQSEWERSELGGVSERLYRQLFSVSLDELHELRTLQGEEVGNYLYHAGVMGGRALTEARRTLAAEMDKLFKPKGTTPEMNKLLALIKETESSIRQRRNDVHYYNETVDALTETESRLTLADRSLPELKAQAADSGRALELREWWLKGLAAEREEAECAAQLSDPLADPLPEDAAVVWAVLVNEREAATDRLEQAKRVLDEKARARARLSWDEGMVDAAAELERLDSLRETTVSRREELASLLVEARAANEQIDDWLARISPHWTEKELQVFSGTTAEREQARRMQQAWGEADRALERLDAEARRLERQKEAWLIQRRDDFLDSEVTARSMSELGSENRSSVIFKPADKASLLQEWLGLEEQLRLLERARATAHAQQASALQASRRSVRGRNDNRAAGGGLLLALSGVTAAAAFIVLAVNGLTPISYGIAGVLLFAAVATASATALMRRREARAVRTGSRQGVDSAQTESNQAVQAQMQLVSDRIRRLVANADSGAAVFSAGGKDYELSVRNLDDAGWSVFREIAYARMDELEREERANEKERERVRRLGEFDREAEAIHRELGRMDAERDRLHMQWREWLEQRKLPAELVPEGMPELFGLAEQAQTLQRRKERLQERAEQLRAAIADFERAAGSLLEQFPAPARSPATLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFK2</accession>
    <name>A0A398CFK2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cation:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_22675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01205">
        <property type="protein sequence ID" value="RIE01205"/>
        <property type="gene ID" value="D3H35_22675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="11"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="407" mass="43683" checksum="84984F092A0BF870" modified="2018-12-05" version="1">MNHIVLEIGLAIALIAMAGLLSAKLRFSVIPFYILIGMAVGPHSFELWHLDFRFIESAPLIDFMGRLGVLFLLFYLGLEFSVGRLIKSGRSIAFGGTIYIAINFTLGLAFGWLSGFPLQETLVVAGITTISSSAIVAKVLVDLKRTANPETEMILGIIMFEDVFLAVYISILSGLVLSGSTSVGGVVLSALIALVFMLAMLTLGRKAAPLLNKLLNIRSNELFALVVFSGLFLVSGFSETIHVAEAIGALLLGLVLAETEHMKRIEKLILPFRDFFGAVFFFSFGLTIDPTTLGGAVWLSIAAVIVTLIGNFTAGMLAGRSAGLSHKASVNIGFTIVSRGEFSIIMANLAKAGALMTIIQPFAALYVLILAILGPLLTKETKLLYRLLNKAFRFEKKSVGVANQSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFQ0</accession>
    <name>A0A398CFQ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECF transporter S component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01255">
        <property type="protein sequence ID" value="RIE01255"/>
        <property type="gene ID" value="D3H35_22980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009825">
        <property type="entry name" value="ECF_substrate-spec-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07155">
        <property type="entry name" value="ECF-ribofla_trS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="250" mass="27852" checksum="3960311310CAA28D" modified="2018-12-05" version="1">MKRIRRAISPKLLLLPIAAAYVGLAYLALQRGNSLLIGLVLVLLSMVPFLWRFERRERQAREMVLIAVMAAIASVSRIPFATLLPGFTPVTFIVIISGVVFGAEAGWMTGAVAALASNFFLGQGPWTPWQMFAWGLAGWTAGLFAHRSPWRRRRIPLLLFGAVWGFLFGWIMNVTVVLDQWTQSHSWETVLARYAAGLPFEIIHATANVFFLAVFAPSWIRLLERYRSKYGILERKGEACDGSQQAANGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGA0</accession>
    <name>A0A398CGA0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_16050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ETF-QO/FixC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02246">
        <property type="protein sequence ID" value="RIE02246"/>
        <property type="gene ID" value="D3H35_16050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039651">
        <property type="entry name" value="FixC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43624">
        <property type="entry name" value="PTHR43624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="432" mass="48095" checksum="27393DA2254D0FA2" modified="2018-12-05" version="1">MSSEKFDVIVVGAGPAGIACAYELAKSGANVLLIERGEYPGSKNVMGGVLYRKMMEEIIPDFHKEAPVERPIVEQRFMMMDKTSAVTFSYKGLEWAEEPYNNFTVLRAKFDQWFAAKAVEKGALLLCETVVLECIVENGKVVGVRTDRPDGELRADVVVLADGVNSLLAKSLGFHKEFRPDEVALATMEVLKLDKKVIEERFNLEEGQGCTIELFGDATKGILGTGFLYTNKDTLSIGVGTLLSGLIKHKIKPYVLMEYVKTHPMIRPYIQGAEPQEYLAHLIPEGGYKSMPKVAAAGVLVIGDAAQLVNAIHREGSNMAMTSGRIAAETIVGAMGRGDFSEASLDGYRKRLMDSFVGQDLKKYKDATHHFDKFPQYFEQYIPMMNKAASTMLTVDGASKWEKQKRIWRDIGPAKQKLKMARDLYRAWRVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGK7</accession>
    <name>A0A398CGK7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-TFIIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_21915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01082">
        <property type="protein sequence ID" value="RIE01082"/>
        <property type="gene ID" value="D3H35_21915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027392">
        <property type="entry name" value="TF_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13453">
        <property type="entry name" value="zf-TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-TFIIB" evidence="2">
        <location>
            <begin position="2"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="173" mass="19910" checksum="00FB511EE81A74DB" modified="2018-12-05" version="1">MNCPVCESTRMREVEKDGILIDICPSCKGVWLDRGELEKLMQGVREVRQDYNEWYYDESRNDRRPQQAQPPKQPEPYPSQSYPPSQQPQGYGSQGSHGNYYPSIRRKRACSTYLEICSTNKRDIVSAKELFRQLLAEAALFCGIVRLRAVASLGERRDGGNNRLRMGYWVGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGT6</accession>
    <name>A0A398CGT6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000061">
        <property type="protein sequence ID" value="RIE00289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00289">
        <property type="protein sequence ID" value="RIE00289"/>
        <property type="gene ID" value="D3H35_29390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="111" mass="12219" checksum="107B39FB91BCA55E" modified="2018-12-05" version="1">MSSRASTYTIRRSARTGATSPSTRTALSIRRCRADRRLYPRPKGGRDALDQQDSGGANADQPADRATLSADAGTIVFRDESDEYGVFVRSGFFHRYLCRSVAVRRVCADLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHE5</accession>
    <name>A0A398CHE5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Asparaginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02626">
        <property type="protein sequence ID" value="RIE02626"/>
        <property type="gene ID" value="D3H35_18260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010349">
        <property type="entry name" value="Asparaginase_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42110">
        <property type="entry name" value="PTHR42110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06089">
        <property type="entry name" value="Asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="338" mass="36166" checksum="7AC90EF38E972F61" modified="2018-12-05" version="1">MTERLATAGDVPLVLTIRGGLPENVHRGRICVVSADNRKIVEAYGDADAAAFIRSAGKPLQAIGPLLGGVAEAYDWEDRHLAMLAASHRGFPAQVEALDEMRKKAGIPEEAFAFRAGAPINAKSRDEWARDGESPRKLYHTCAGKHLGMLAWSKLSGWPLEGYTRIDHPAQKQVVRHIRSWTNTDENDSAFGRDGCGLPAAAVPLRSIALAYARLACLDTAPAAASTEAAGRVAQAMNRHPELVEGQGRLASLLLADPNIVAKSGAQGLFAIGLRRERLGIAIHVSDGSEMPWALIAIALLKRLGGVSAQTMASLEARYPSEYVNDTGDVAGHKETLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHG8</accession>
    <name>A0A398CHG8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine kinase</fullName>
            <ecNumber evidence="1">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_15800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02203">
        <property type="protein sequence ID" value="RIE02203"/>
        <property type="gene ID" value="D3H35_15800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011623">
        <property type="entry name" value="7TMR_DISM_rcpt_extracell_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07695">
        <property type="entry name" value="7TMR-DISM_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="7TMR-DISM_7TM" evidence="4">
        <location>
            <begin position="182"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="5">
        <location>
            <begin position="450"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="646" mass="72690" checksum="18DA3C9CC380E59E" modified="2018-12-05" version="1">MNGFLRAHVPLIRTLALLAALLFAVGWGLTSLEKKDGTVTLPDDGWEWHPADSLEEAAPPPTGSDWSSFSGTVDRTYRYYWLRVPLPEESGLENPYLWIINVGSMKAFDEDRLLLDANFMKKGVRLSASFHWKLVPLPSPAPKQVYLLLRNSVSGGVSPWIDYGNKSAHVNRILHEDMDNIVLGGMLLFSCLISLGLYASHRDKLYAYFALLAFAGGYASLVRNHLLQFFWNSPWPAYLQDVCMPWATFATLGIMASLFPGHLTLANRILRVFMLVLSIAMTISAAFFFDVYGFLGEMVYPPAFLFVFCIVFISIFAAYKRRKDVESVWVLAGFILLLAIALIHILRFAWLPGITDWLRAHIAWINSLPFDLLFWGLFGFVICLIRVIMYRYTAMNRQLTEWNRSLEQVVQNRTHELKERNEQLEITHERLAATIRETSEALAETIILEEQHRITGTIHDAVGHTLTETIVQLEAAKRLLHRDRTLAESKLEASQSLVRRGLADIRQSVRLLKEDTEHYDLPGAVGALIRETEKEALCSIECKIGKLPESMSILHKRIVFQTLQEGLANGIRHGQARFFQLSLGVSGDCVKLRLSNDGLTYVPSDFGFGLEEMTDRAARLGGLLKVEPGTPGCVITLSLPVGSPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHH6</accession>
    <name>A0A398CHH6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Large-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">mscL</name>
        <name evidence="11" type="ORF">D3H35_15865</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MscL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02213">
        <property type="protein sequence ID" value="RIE02213"/>
        <property type="gene ID" value="D3H35_15865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00115">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019823">
        <property type="entry name" value="Mechanosensitive_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01264">
        <property type="entry name" value="MECHCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01327">
        <property type="entry name" value="MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE02213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="166" mass="17814" checksum="D65303869A1B49DF" modified="2018-12-05" version="1">MFKSFFGEFKTFAMRGNVVDLAVGVIIGGAFGKIVTSLVNDIVMPPIGRLLGGVDFTDLFINLNPEKLTKAKEVPKTLIQAQEAGAAVIAYGQFINVMLDFIIVAFCVFMLVKLLNKLSRKKEAAEEAAPAAPTTKECPYCISEIPIAATRCGHCTSELNASPARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHY9</accession>
    <name>A0A398CHY9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spore gernimation protein GerPD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_26570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00759">
        <property type="protein sequence ID" value="RIE00759"/>
        <property type="gene ID" value="D3H35_26570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="84" mass="8462" checksum="D957EC1FAF08DB26" modified="2018-12-05" version="1">MSLCSVVLNVNNGPLNVGDIRIIGISSSSALLVGDTDSFALYSFFDTPPESLVVGPLAPLPGIPGTDVSIEGEVEAAEGESGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIN6</accession>
    <name>A0A398CIN6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron transfer flavoprotein subunit alpha/FixB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_16045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02245">
        <property type="protein sequence ID" value="RIE02245"/>
        <property type="gene ID" value="D3H35_16045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="2">
        <location>
            <begin position="9"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="343" mass="36644" checksum="C105CDE9531C9052" modified="2018-12-05" version="1">MNFDDYRGVWVFIEEKDGAIAPVSLELLGAGRQLAEKRKTALAGVIIGENVGDLAQSAFEYGADVAYVYDDPIFRHYRTETFMKAMLACVQKHKPEILLYGATSTGKDLASAVATDLPTGLTADTTQLDVEEDTGLLLASRPAFGGNIMATILCKKYRPQMATVRPKVMKALPCEKGRSGEIIQESIPLVESDVRTKVLEIVRATEKRVKIDEADIVVAGGKGLGGPQGFQLVHRLADVLGAAVGGSRDVVEAGWIGHHHQVGQTGATVTPKIYFAIGISGAIQHIVGMQNSGLIIAVNKDPKAPIFGACHYGIVGDALEIVPLLIEGFKAALGRKEENANVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIT6</accession>
    <name>A0A398CIT6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellar biosynthesis protein FlgA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02643">
        <property type="protein sequence ID" value="RIE02643"/>
        <property type="gene ID" value="D3H35_18360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="238" mass="26086" checksum="041B3262553694DA" modified="2018-12-05" version="1">MNRKRQAAISLSAAVLSGMLVYGVYWLQLRQVKERETTGVVVPNRFIPAGTTLTRESLQLLSLPKAAVTDEMVTDLLEAVGMETAAPLGESEPLLRWKVDRFRLMPKKGQATFLIPRDYVRSIGSGIRAGDRAVVYISGEDMPSRRMFADPVVVAGVKTASNLEIDDPKNPNLLSMANGNKEGMYASRRDANGTIDAINLNLTEEQWLQIDTACKSGKAKLVIAFDASTFEIPERGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ70</accession>
    <name>A0A398CJ70_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02385">
        <property type="protein sequence ID" value="RIE02385"/>
        <property type="gene ID" value="D3H35_16865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="154" mass="16877" checksum="1A6E637FF6833AB6" modified="2018-12-05" version="1">MNDYPHRGLGGWQQGPGLGGEAFPGIGESLSGPPALANPQVLPAAQAATKAAGGFSLANLSDLKSVIDRMGGIEGVLSTVGKVQKFMSTMQQVAPIIKLFMNKGKSSKTKDDDDEDDDAAPRRRRRRVGSGKSRRNRRIRRNRRRRQRRRAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ73</accession>
    <name>A0A398CJ73_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02162">
        <property type="protein sequence ID" value="RIE02162"/>
        <property type="gene ID" value="D3H35_15550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000428">
        <property type="entry name" value="Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00944">
        <property type="entry name" value="CUEXPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00003">
        <property type="entry name" value="TIGR00003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="66" mass="7097" checksum="94C62FADC14C1072" modified="2018-12-05" version="1">MKNVTLKVEGMSCNHCVNSVEGTLKTLGAQGKVNLPSGTVDVAFDDSRLTIDQIKEAIEEQGYDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ81</accession>
    <name>A0A398CJ81_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_15630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02172">
        <property type="protein sequence ID" value="RIE02172"/>
        <property type="gene ID" value="D3H35_15630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012744">
        <property type="entry name" value="Nitri_red_NirB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017121">
        <property type="entry name" value="Nitrite_Rdtase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037149">
        <property type="entry name" value="NirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02374">
        <property type="entry name" value="nitri_red_nirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="7">
        <location>
            <begin position="5"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin_C" evidence="8">
        <location>
            <begin position="318"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="6">
        <location>
            <begin position="413"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="6">
        <location>
            <begin position="479"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="5">
        <location>
            <begin position="608"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="767" mass="82520" checksum="7D0B11729C2DA0CC" modified="2018-12-05" version="1">MSKQKLVLVGNGMAGVRCVEEILKLSPDAFDITIFGSEPHPNYNRIMLSKVLQGDTKVEDITINDRKWYSDNGIALFTGETVTHIDTEQRRVVSDSGRSVPYDKLILATGSLPFMLPLPGADKPGVTAFRDINDCNKMMAASRKYKNAVVIGGGLLGLEAARGLLNLGMSVHVVHIYKHLMERQLTPTSAQMLKTELERQGMRFLLEKQTEMVLGKKRVEGLLFKDGTKVAADLVVIAVGVRPHVQLAKDGGIEVNRAIVVDDRMRTSVPGVYAVGECAEHRGMVYGLVAPLYEQGKVLAKEICKMDTEGYAGSILYSQLKVSGVEVFSAGEIRDSEAETALKIYDGKRLTYKKVTMRDGKIVGAVLYGDSSEGNKLLSYIKQGADVSVLEEPVSASGSSEEERIAAMPDKETVCSCNGVTKGAIMEAIRCDGLQTFEEVRACTKASSSCGGCKPLVSGILAYTLAHPDAASEKPKEAVCGCTTMDHEELKTALRGGAYRSVSEAMAGLGWARADGCPICKPAVRYYLGGIAVAEPGAEARAVTPRMYGGVTNAEQLRRIADVIDKYDIPLVKLGSSSLDLLGVAGPFSELIDAELGMPYAQNTYGHAVSSVGTCAGLSFDGQAMQDSVGMGARLEKRLQAMQMPAAFSAAVSASPLHRAGTLAKDLGIVGTPGGWEVYVGGSGTDFVREGQLLYSESDPDAVLDVASAFAQWYGEDARYRETTAQWIERVGLIPIRESLFQRDVREELLARIKLDHQQATAVTVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJA2</accession>
    <name>A0A398CJA2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02425">
        <property type="protein sequence ID" value="RIE02425"/>
        <property type="gene ID" value="D3H35_17115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="263" mass="30078" checksum="9623EE08155CE0EC" modified="2018-12-05" version="1">MWTEIAAFLKANTTETLLISIIGTILVWMYKQFKGMIDRKQQNELTIAQLKQGLFTKLELSIASVLHLDNEGSKQQMYALLGECGPYLTSTQRTVIRDYYKQFNPMLLHSLQALTVNEVEKLGRQLDKIRENEDSSEWFSYIMRLYAPFGPILLFVMITLYIVFVFSLVREGASLWIQICILLLGATVFVSATLFISMIVLFVRRELAKQGVKRWCAVALIIASPVLAFAVNRLDMSIIVLVIQILGLVMMSRFKRPSEIVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJB2</accession>
    <name>A0A398CJB2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02212">
        <property type="protein sequence ID" value="RIE02212"/>
        <property type="gene ID" value="D3H35_15860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="222" mass="25166" checksum="29E3D9A00D6B6DEA" modified="2018-12-05" version="1">MSSEERFDIYDDDGSPIGTASRKDVHRLGYWHHTFHCWLARRMPDGRTAVLFQRRAESKDTNPGCFDITVAGHLSAGETLQDAVREMDEEIGWSVPFERLVPFGTIRENASGELRGVPYIDREISHVFGCLTSHPLNRFKLQEEEVAGIYECDAERLIDLMEGRIAAAQADGFRLGKIGLSESSATLRVSDFVPRDLSYYVDVFRFLLSLTERGEIDSFDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJM3</accession>
    <name>A0A398CJM3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pro-sigmaK processing inhibitor BofA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_21600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01038">
        <property type="protein sequence ID" value="RIE01038"/>
        <property type="gene ID" value="D3H35_21600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010001">
        <property type="entry name" value="BofA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07441">
        <property type="entry name" value="BofA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="88" mass="9546" checksum="7378151BA48647EC" modified="2018-12-05" version="1">MKTMWMILLIVSASLLGIVLIRQRLPLGWLTRFGAHLVLSALVIYALNFSGWITGWYVPLNPATIGAVTLLGLPGIGLVLGLQYTLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJY0</accession>
    <name>A0A398CJY0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000035">
        <property type="protein sequence ID" value="RIE03616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03616">
        <property type="protein sequence ID" value="RIE03616"/>
        <property type="gene ID" value="D3H35_10780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="91" mass="10148" checksum="7D41746C01CA76C0" modified="2018-12-05" version="1">MPESGPEAERLSEIVVELKRDGERSVSVSLNPESLEVEASLPFPIGDVILRREDSGEYSCKVTAIRLSGETVKDWKKKTGDRLFILQDDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK55</accession>
    <name>A0A398CK55_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_24855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01579">
        <property type="protein sequence ID" value="RIE01579"/>
        <property type="gene ID" value="D3H35_24855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="450" mass="48899" checksum="A1BBF5C38BB969DB" modified="2018-12-05" version="1">MEAENLHYFEKAPIAKAVAHFAIPMMLGTSMSVIYSILNAYFLGTLHNTAMLTALALTLPLFAVIMALGNLIGMGSGTFISRLLGEKKYDDLKHVSSFAFYSSIVLGLIVMAVGLPLIDPIVHGLGATPESFGFTKDYVTIMLIGSPFVVLFFTLENIVRSEGAAITSMIGMILSVIVNIILDALVIFVFHWGVIGVASATVISNLAASAFYAFHMGYKSQFLTVSVKWFKATKDILSNVFKIGVPVFVMSIFLGAMSLIFNHFLVEYGDQAIAGYGISSRLLQFPEFILMGLCEGVVPLIAFSFTANKLRMKHTIGFTIKTIVALAVVFGVIVYLISDHLIGLFTNDPKLIEMGSYILHVTFLSLFITGMTSLFTGIFQATAQGTAAFIMSVIQGITLIPVLYIANRMNGFHGVVWSIVIADAVAFLVGAIMLYVLRNKLQPDLDSLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLA6</accession>
    <name>A0A398CLA6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01969">
        <property type="protein sequence ID" value="RIE01969"/>
        <property type="gene ID" value="D3H35_14455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="38" mass="4067" checksum="3D9EADDC65AA1908" modified="2018-12-05" version="1">MKWSFGVAMAVATVPPFFRWLGTVPGLGGASGEERREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLB3</accession>
    <name>A0A398CLB3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_08830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04136">
        <property type="protein sequence ID" value="RIE04136"/>
        <property type="gene ID" value="D3H35_08830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="17"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="273" mass="30343" checksum="5DFD156F428F251B" modified="2018-12-05" version="1">MKTGPSARENQGDEAVLLAERLRKSYRLPGQGASNVLNGIDFAVGRNETVGLVGGSGAGKSTIGRIVAGLEKPDGGRLLFEGKDLLRMNARERRHAAQDIQTVFQDPYESLSPRMTVQQLVAEPLVIRGRKTEDAEQRRELVREALEEVSLTAERYMSRYPHELSGGERQRVGLARAFICRPRLIVADEPTSMLDTSLRLELLQVMKRLSVKHSVSYLFITHDIALTAGFCDRLLVLNCGEIVEAGPVRDLIARPQHPYTQSLIGALKELDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLD9</accession>
    <name>A0A398CLD9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-glycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_12980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01718">
        <property type="protein sequence ID" value="RIE01718"/>
        <property type="gene ID" value="D3H35_12980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="6"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="108"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="323" mass="35487" checksum="88F0DCB604EF38E1" modified="2018-12-05" version="1">MKPRVYIARDLPEEVRAYLEEHCDVRMWQGAEPIKPEQLKQEVGDAEGLLVTGTPVGEEVLRAAPKLRVVSNLSVGYNNVDLAALKAGKVVGTHTPYVLDETVADLAFALILGTARRVAELDRFVKAGKWQKGQDAELFGVDVHHARLGIVGMGRIGEAIARRAKLGFLMDVVYYNRNPRPDVEARLGISYSTLEELLRTSDFILLMTPLTPQTKHIMDEAQFSMMKKSAIFINVSRGETVNGTALVRALQSKQIHGAGLDVYEREPVDANHPLLGMDNVVTLPHLGSATAATRLNMAFAAARNLVHALKGEEPIQIIPELQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLW8</accession>
    <name>A0A398CLW8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_12815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000038">
        <property type="protein sequence ID" value="RIE03250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03250">
        <property type="protein sequence ID" value="RIE03250"/>
        <property type="gene ID" value="D3H35_12815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="480"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="557" mass="61692" checksum="20DB7E56B82FF5F0" modified="2018-12-05" version="1">MDLPGAERAGQSAGALFAEERRRPRYARWSISGTDARHSRRSVRDSQGGRSLRAARSALSEGSHRGHVGRFPRSDHRNPFGFGFAASCGLRRENRAIRRGTGRHIPESALNPEGGAEPRHLAYVIYTSGSTGRPKGVAIEHRSTTRWIYAAQELFEPEKDFAGVLASTSISFDMSCFEFFVALGSGGKAILAENALHLPLLPAREEVTLINTVPSAVAELVRSKGIPDSVRVCNFGGEPLFGSLVRQLFKRHPSVVRAYNLYGPTEDTTFSTYEIVRGGEEGEPTIGRPIPNTTVYILDSERQPVPIGVHGELYLGGDGLAREYLNRPDLTGERFVPNPFSDKPGERLYRTGDLVRFLPDSRIQYFGRLDHQVKIRGFRIELGEIESVLLAHPSVSEAVVQAREGEKGRKRLIAYAEVANKDATSTELRSYVKSRLPDFMVPSAIFTLDKFPLSPNGKLNRLALPEPDVSWFGSEHPYEEPRDDIERKLARSWQDLLGIERIGIHDNFFESGGDSLLSERLAADLAKEGIRIASRDLFGFQTIADLAAWIRSKALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLZ9</accession>
    <name>A0A398CLZ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkaline phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03465">
        <property type="protein sequence ID" value="RIE03465"/>
        <property type="gene ID" value="D3H35_12465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="432" mass="47909" checksum="118ECB8C43ACF269" modified="2018-12-05" version="1">MNFLHNAMNHYGYWVLGLGLMLEVLALPLPGEFLMSYAGLLVFEGKLNWFASMLAAGAGSSLGVTAAYWIGYAAGRPFFEKVGSRIHLGPDKLDKASVWFDKYGNKVLLIAYYIPGIRHFTGYFAGVTRLPFRTFALYAYTGAFIWTGLFITLGKILGPQWDHFHHSIRKYLIFAGILGAILLLAYYTIKNRKVRVKQAVLRFIANGSSAFRTVRKAEWAIAIACLVLVAAVTWAVVIIQDFLAHEFSDFDQIAPLVIHAVFDESWKSLFSGTMQAASPIILAPIVVLSLIAVWKLRGKRLEEAALYSFGIFGGIIWEYGLRHLFAGTGPELSAYSFPCEPVSLIMVVFGLSAYYVGRSVRRRRIQISLGGVAVIASLFAGVACIYLNRYDASDVTAAFAFTGVWLSSNVVLVELFRMLRKTQKQTRPSDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM60</accession>
    <name>A0A398CM60_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="5">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP cyclohydrolase I</fullName>
            <shortName evidence="5">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">folE</name>
        <name evidence="7" type="ORF">D3H35_16435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02309">
        <property type="protein sequence ID" value="RIE02309"/>
        <property type="gene ID" value="D3H35_16435"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="6">
        <location>
            <begin position="21"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="199" mass="22400" checksum="7662CB42D08BA5C3" modified="2018-12-05" version="1">MTVAGAKDYVNKQVGDNREQIEYHMKEVLKLIGEDVEREGLLETPARVTRMYEEVFAGYSVDPRDVLGVTFDEKHEELVIVKDIVYYSQCEHHMAPFFGKAHIGYIPSGKIAGLSKLARLVEAITRRLQVQERITSQIADILEEVLQPHGVMVVVEGEHLCMCARGVKKPGSKTVTSAVRGQFRQSAALRSEFLSLIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM69</accession>
    <name>A0A398CM69_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0234 protein D3H35_11740</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0234 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03350">
        <property type="protein sequence ID" value="RIE03350"/>
        <property type="gene ID" value="D3H35_11740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11740">
        <property type="entry name" value="YajQ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00632">
        <property type="entry name" value="UPF0234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007551">
        <property type="entry name" value="DUF520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035571">
        <property type="entry name" value="UPF0234-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035570">
        <property type="entry name" value="UPF0234_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036183">
        <property type="entry name" value="YajQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30476">
        <property type="entry name" value="PTHR30476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04461">
        <property type="entry name" value="DUF520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89963">
        <property type="entry name" value="SSF89963"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="163" mass="18372" checksum="FAA39338E8F446D9" modified="2018-12-05" version="1">MASEYSFDIVSKVDMQEVNNAVTQALKEIETRFDFKGSKSDIKLENEALVVASDDEYKLKNVIDILQSKLVKRGVPIRNMDYGKIEPASGATVRQTIKLKQGVEQDIAKKINILIRDSKSKVKSQIQGDQIRVTGKSKDDLQAIMNLLRGADLPLELQFVNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM88</accession>
    <name>A0A398CM88_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance/extradiol dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03370">
        <property type="protein sequence ID" value="RIE03370"/>
        <property type="gene ID" value="D3H35_11875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="138" mass="15578" checksum="15D259095F337D66" modified="2018-12-05" version="1">MALMSTFTSFNLPVNNVEQSKAFFTGLGFELNPQFPENEKSVAIVIGDNLQVMLLTKELLKSLTQKETVDTEKYAQMTIALAFESREKVDEIVNTAVSLGGKSYEEPEDYGFMYHWAFEDLDGHMWAINYMNTDAAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMG5</accession>
    <name>A0A398CMG5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_21885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01077">
        <property type="protein sequence ID" value="RIE01077"/>
        <property type="gene ID" value="D3H35_21885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="269" mass="30552" checksum="B56E9FBB581ED074" modified="2018-12-05" version="1">MGGTLRKGWDMTVRHKYVLVLFFLYRLLWGFFIYRFIDSVVTPILSRYPNEHPNAGAAELFAIEAQFRLLRTDLIDETLWTLGGMILTRMLLTPLLNAGLYYSFNHSADGQGTRMLTGMRRAWKPIVVLYLAETFLLLLPAVWLLPMAKDRFFSNGSMQEWIFGLLPYFAGWILWGFLLHLAFQFMQFGAVAGESVWKGLLGAVRKALPLTIVTLLLAAFGLLASAAASSISILWSGFLAVVLHQAFHFIRSMLSVWTAASQFEIWRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMG9</accession>
    <name>A0A398CMG9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_05535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04556">
        <property type="protein sequence ID" value="RIE04556"/>
        <property type="gene ID" value="D3H35_05535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="90"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="318" mass="36202" checksum="58007FF9C0F3D11B" modified="2018-12-05" version="1">MEIEIARAPIESPRRLARRRLLRRIWRYKMLYLLLLPAFIWVVLFDYLPIYGISVAFLDYNFIKGISGSEWAGLKYFRQLFESEMFRNALKNTIIINAYKMISGFVCPILLALALNEIRKPWYKRTLQTAVYLPRFVSWVVYGGIITLLLSPETGIVNQLIEFFGGKSIYFLTEPSLFRAIVVFTDAMKEMGWAAIIFIAAIAGLNPEVYEAAIMDGATRFQRMWRITLPGITSTIVVIFILRIGYIMSAGLDQIINLYNPTVFEVGDILDTYIYRVGIEQFNFSLAAAADLLKGVVGLSMVLAANHLAKKINDSGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMN2</accession>
    <name>A0A398CMN2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF72 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02499">
        <property type="protein sequence ID" value="RIE02499"/>
        <property type="gene ID" value="D3H35_17565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="287" mass="32777" checksum="67A0E1472A434857" modified="2018-12-05" version="1">MISIGLAGWGDHDKLYPERLKAKDKLKEYSRHFSTVEVDSSFYAIQPSDRFRRWAEETPDDFRFVVKAYQGLTGHQRGGVAADQSELFGAFRESLQPVLEAGKLTAALFQYPPWFDCTRANVEMLKEARKRMEGIPCALEFRHQSWFRPEYREKTLAFMAGEDWIHSVCDEPQAGEGSVPTVLQATNPGMTIVRMHGRNMSGWSQASAPNWREVRYLYRYGQAELEEWRNNVLELAEQSRDVCVIFNNNSGGDAAENAKQLMAMLGQEPIGFPEPEPSPEQLDLFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMX8</accession>
    <name>A0A398CMX8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_04270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04706">
        <property type="protein sequence ID" value="RIE04706"/>
        <property type="gene ID" value="D3H35_04270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021731">
        <property type="entry name" value="AMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11741">
        <property type="entry name" value="AMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017225680" evidence="3">
        <location>
            <begin position="25"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="MurNAc-LAA" evidence="4">
        <location>
            <begin position="395"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="507" mass="54467" checksum="E4C20E2A593F3EC9" modified="2018-12-05" version="1">MKKWSFLLFVVAFALFLNAGVIHAAVKAPVEPPAPPTLVLDGTVLKPVTAPIILNDYTMVPVRTVADNLGYLIDYDNKKKQVTVTKDSTKILMTIDDKTAFVNGAKLTLQQAPTIRSSYTLVPLRFIESFGVQVYWDSPTRSVFMFSGKSNGNGNSGSGDGGLIGVVDPDEDGSSGGVVDGGNPSDGGESGNPSDGGNPPDGNGTVTTPDLKGQIHEIRYDADTITVKYDGSLTPVTSVLKSPDRIVIDLPSSEFAADFVPALPVTASASKSGELAVTGHEALQKIRYAINTVNPLTMRIVLDLNQQWNFSVTDDAAAHELKIALKKPDPQVYTVVLDAGHGGSDPGAKSITGKWEKQFNLSVVLKVQALLAKESRINLVLTRQGDTYPSLDDRVNLANSLKANLFLSVHANSYKPEINGTETYYNRADSLEFAKLLHKNAVAAAGLKDNGVRTAGYKVIKYTTMPAVLLEVGYLSNKNDEKQLYDDAFQNRVAQAIAASIKQYFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN52</accession>
    <name>A0A398CN52_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Molybdenum transport system permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cysT</name>
        <name evidence="13" type="ORF">D3H35_10535</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03722">
        <property type="protein sequence ID" value="RIE03722"/>
        <property type="gene ID" value="D3H35_10535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011865">
        <property type="entry name" value="CysT_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011867">
        <property type="entry name" value="ModB_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005667">
        <property type="entry name" value="Sulph_transpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406">
        <property type="entry name" value="PTHR30406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00969">
        <property type="entry name" value="3a0106s02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02141">
        <property type="entry name" value="modB_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02139">
        <property type="entry name" value="permease_CysT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="58"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE03722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="271" mass="29709" checksum="347D57FC03EC2707" modified="2018-12-05" version="1">MSSMLQSRWWSFGFRSAVMLYFIVLIVLPILGIYGQSLSGGWTVFVDNVTEPLAWKAVSLTVQMALIATVINIAVGTMSAWVLIRYRFPGRRLLNSLVDLPFALPTAVAGLMVLLLLGPNSWVGQWAERLGFTILFHQPAIVIAMIFVTFPFVIRAVQPLLEEMEASEEEAAYTLGATKAKTFWRVILPNMLPGILSGAMLAFSRALAEFGAVVLVAGNIPGKTLIASVYIFGEIESDNSTGAAAVSVLLLTLSFLILWFVNYVQMRRKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CND9</accession>
    <name>A0A398CND9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04123">
        <property type="protein sequence ID" value="RIE04123"/>
        <property type="gene ID" value="D3H35_08025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005085">
        <property type="entry name" value="CBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03423">
        <property type="entry name" value="CBM_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01066">
        <property type="entry name" value="CBM_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="29"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="129"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="328"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1077" mass="115159" checksum="99C0614D05AA0692" modified="2018-12-05" version="1">MLAKDVAGNSSAQSAALSVTTSPIVDTTAPSIPTGLVKGTVTSSSAAISWTASTDNAGGSGVASYDVYRNGALVKAGATATSYTDTGLAASTTYLYTVLAKDVAGNSSAQSAALSVTTSPIADTTAPSVPTGLVQGSVTSSSAVISWTASTDNAGGSGVAGYDVYRNGALVKAGATATSYTDTGLAASTTYLYTVLAKDVAGNSSAQSTALSVTTSPVAQGNTAEVYYYTKTRGWSSVNIHYMPTGGSWTTVPGVPMNESACTDWAKKTIDLRTATGMKVAFNSNGSVWDNNNGSDYSLGYGIITVKDGVVTANAASPCVTLPPDVTPPSVPLNPAAVADGVKITVTWDSSTDNAGGRGLAGYEITRTGGTQGTKLFSATSNVFYDSGLDAQTTYTYTIKAYDKATPSNVSASSVAVSAKTGDAPPPPVGGTPLGTDMREDSIYFVMTARFYDGDSSNNRGGQLNVSSGNAANNDPMFRGDFKGLMDKLDYIKALGFSAIWITPVVLNRSDYDFHGYHGYDFYRVDPRLESSGASYQDLINAAHNKGIKIIQDVVYNHSSRYGAKGLFTPTVFGIRDSQWSWYYDEKVAGQQYDPLTPTSVSAKPYNGDLWSTEEPVGNTCRNWGTPTQNFSKEGYRIYNCQWPNPTSGMFPSLYYHQCWLGNWEGEDSRSCWLHEDLADFNTESKPVQDYLIGAYNNFIDMGVDGFRIDTAVHVPRITWNRHFLPAAQEHAVTKFGDKGKNFFMFGEVGAFVNDKWNRGSVNHSAQFFTWKERKEYTLDDVQAALDQYNYENQQGTANQPTSTNAFLTGNLYHTPDHSKFSGMNIIDMRMHMNFGDANNAFSNGKDSDDSTNDATYNVVYVDSHDYGPNKSSTAYSGGTDAWAENMSLMWTFRGIPTLYMGSEIEFQAGKQIDCGSSCPLATTRRAYFGDKIEGTVTASDFGKVSSASGTVASTLNYPLVKHVQRLNQIRRKIPALQKGQYSTEGVSGSMAYKRRFTDSAKGVDSFALITVSGSATFNGIPNGTYKDAITGDVKNISNGTLTANVSGKGNLRIYVYDQAGNPAPGKIGEDGPYLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNH2</accession>
    <name>A0A398CNH2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase iron-sulfur subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_19380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02799">
        <property type="protein sequence ID" value="RIE02799"/>
        <property type="gene ID" value="D3H35_19380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="255" mass="28361" checksum="158D3CCB7AEF9989" modified="2018-12-05" version="1">MADTATKQRTVKFIITRREKPDAAPFTEEFDIPYRPNMNVISALMEIQRNPVKADGGKTSPVCWESNCLEEVCGACSMVINGKPRQACSALVDKLEQPIRLEPMSTFPVVRDLVINRERMFQALKKVKAWIPIDGTYDLGPGPRMAEEKRQWAYELSKCMTCGVCLEACPNVNDRSSFIGPAPLSQVRLFNAHPTGEMNAGERLDTIMQDDSGIEGCGNSQNCVRSCPKGIPLTTSIAALNKDTTKHMFKKWLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNJ4</accession>
    <name>A0A398CNJ4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Type 2 isopentenyl-diphosphate Delta-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_03385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooctamer. Dimer of tetramers.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000019">
        <property type="protein sequence ID" value="RIE04936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04936">
        <property type="protein sequence ID" value="RIE04936"/>
        <property type="gene ID" value="D3H35_03385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011179">
        <property type="entry name" value="IPdP_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43665">
        <property type="entry name" value="PTHR43665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02151">
        <property type="entry name" value="IPP_isom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_dh" evidence="6">
        <location>
            <begin position="9"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="238" mass="25714" checksum="5E8239FC1A39C5BB" modified="2018-12-05" version="1">MNEKEKSTATRKSDHIRICLDEQVSGQGVTTGFEHYRFRHSALPELSLSETELSVDLLGKKLKTPLLISSMTGGTEQTGAINRRLAEAAEARGWGIALGSMRAAIEREELASTFRVRKQAPTTLVIANLGAVQLNYGLGPEDCRRAVALAEADALVLHLNALQEAFQPGGDTDFGGLLRRIEEVCRRLSVPVGIKEVGWGIDSDTARRLTDAGAAFIDVAGAGGTSWSQVEKLRQSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNK2</accession>
    <name>A0A398CNK2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_03140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04946">
        <property type="protein sequence ID" value="RIE04946"/>
        <property type="gene ID" value="D3H35_03140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="29"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="246" mass="27952" checksum="DFCCA413093A696D" modified="2018-12-05" version="1" fragment="single">MPLTPNGKLDRKALPSPEGTLERGTVYEAPRNALEETLADIWQGVLGVSAIGITDNFFELGGHSLKATTLVTRIHKELNVQVPLREVFQSPTIKELAQAIRGMEAHAYASIEPTPLREYYPVSSAQKRMYILSQLQGAEQSYNMPGAVMMEGKVDRERFERAFRQLIARHEALRTSFEWVEGEPAQRIHLEVDFEISYKKAEEDGLRQIAEFIRAFDLGQAPLLRVGLLELEPERQVLLYDMHHII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNP1</accession>
    <name>A0A398CNP1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03860">
        <property type="protein sequence ID" value="RIE03860"/>
        <property type="gene ID" value="D3H35_09935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="66" mass="6774" checksum="0B076316321ED7AF" modified="2018-12-05" version="1">MGGSERHSDASPARLAQDVVDATPDGKDDLDMSGAAGTRKASGCNDIRPGTGRSAINVIHELTAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNQ9</accession>
    <name>A0A398CNQ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_27780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00544">
        <property type="protein sequence ID" value="RIE00544"/>
        <property type="gene ID" value="D3H35_27780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="8">
        <location>
            <begin position="46"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="9">
        <location>
            <begin position="281"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE00544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="411" mass="46789" checksum="79F35026B363A038" modified="2018-12-05" version="1">MDSINRTNRTDRRRCRTKRRKASRPTCSRDRHSILLKQGLVIMEISIIVPCRNEGANVEILTNRILRAVPGDVTYEIVFVDDSSDDTPERLDRMSRQFSFVRYLHRENGGGLSSAILEGCRMAKGDWFIVMDADLQHPPESLPALIEEIRSERSEVIVPSRFIPGGSDGGLNAWRRLVSWTARMMARLLIRKVWKVTDPTSGYFAVRRDVAFSRPLQPIGWKILLELLVRSDYSNVREIPYSFHSRDLGSSKLNLKEQWNYIRHLGRLLRSSESDMRFWIFCAVGLSGVAVNTLVYVLLVHLGVPIGFSFAGATIVATFNNFTWNNLLTWKDSKSDKLWYRIFKFSLVSLSGLCLSSFIVTCFHSWFGVHYLVAGLIGILVSTGSNFALNNVWTFKKLPAILSPISKDPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP54</accession>
    <name>A0A398CP54_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bacillithiol system redox-active protein YtxJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ytxJ</name>
        <name evidence="1" type="ORF">D3H35_07080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04353">
        <property type="protein sequence ID" value="RIE04353"/>
        <property type="gene ID" value="D3H35_07080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022551">
        <property type="entry name" value="BrxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11009">
        <property type="entry name" value="DUF2847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04019">
        <property type="entry name" value="B_thiol_YtxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="116" mass="13101" checksum="5226C14DEC610704" modified="2018-12-05" version="1">MADIKQFTTLEQWNEALGKTSEKPLLIFKHSTSCSVSAGAHEELLKYVSDYEASDVDFAIVHVIEDRPVSNEIAEKLDVQHKSPQAILVDKGNQVWNESHWRITYSFLADKLGNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP56</accession>
    <name>A0A398CP56_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_21085</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03079">
        <property type="protein sequence ID" value="RIE03079"/>
        <property type="gene ID" value="D3H35_21085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="301"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="372"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="659" mass="71239" checksum="FBC1E0076A9A1CED" modified="2018-12-05" version="1">MKLFLLIFCSILACVVTLGIFSYSKSSSIIKNKVAEASRQTAEQAAGKFSLLFDGYERLSLQFITDSGFTDLINTLAAANDDYEKFDMSRKLTEKMSGMAMSDSTLESISLVPVNEKDQTMTTGGTLRREGLTSTPILEKIKEGSGKAVWIPTMTKGVDGSRTFPTFAVGRYLSLGKQYYLLIEIKAAVLDSLMQTVQFGEGSSSYIVSQDGGIVYGPDNGKLGTKYSFELPGESGTATIKENDQEMLSTAGTMDTSDWTLLGNIPVSSLVKDAKAISNLTWLMSLLAALIAAAIGLIVLRTVGRPLVQLRTLMNEGEKGNLTVRSTIRKKDEIGQVADSFNRMMEEITTLVRQTNSSAKEVLDTATSLTDASRKTAEAAKEIAIATEEIANGATNLAFESEKGTDMTSEIGTQVQTVIASNVEMGNSANEVEEASRRGSDYMDTLINKTGQTEEMTRSMVEKVDKLKDSTRSIRKILDVLGNMTKQTNILSLNATIEAARAGTAGKGFMVVADEIRKLADQSRQSIGVVGEIVETIQREIDETVAVLSLAYPIFQEQIESVREANQIFVAVQDNMSSFVGRLDSATVSVRQLESAQSTLSLAMSNVSAVAEEASATSEQVASLSNEQLGISDGLVQLSNRLESVSTQLRESLSRFTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPJ5</accession>
    <name>A0A398CPJ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_06800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04312">
        <property type="protein sequence ID" value="RIE04312"/>
        <property type="gene ID" value="D3H35_06800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="131" mass="15559" checksum="1286CF9988546D5F" modified="2018-12-05" version="1">MEKKTRPQAGLLLFLILRTFEIRKNRVIFDNAAAYNLRKPLIEFEIERMSVMNMTIRQLAETTSDLLYRVRVYDRDLKYSDEIIAMDDTHSALKKAVLHGEGGRHRERAIEKLQQMRRRLLTMMEDLLYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPS5</accession>
    <name>A0A398CPS5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000006">
        <property type="protein sequence ID" value="RIE05416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05416">
        <property type="protein sequence ID" value="RIE05416"/>
        <property type="gene ID" value="D3H35_00575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="127" mass="14055" checksum="9BF971C38B16CE81" modified="2018-12-05" version="1">MRSATKSRVRIQAGSKRQLIIDELLESIPANKLFAEFDLGWIKVAGQDPAAYVAKYAGRLPLVHAKDFKPTASIRKSAAARSTGTPALAASEQAGVEYVIIEQERYDISSLESAQLNFAWFKERGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ05</accession>
    <name>A0A398CQ05_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01054">
        <property type="protein sequence ID" value="RIE01054"/>
        <property type="gene ID" value="D3H35_21715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="164" mass="18005" checksum="B7E68EDABA1B3FE2" modified="2018-12-05" version="1">MTCEFGKPSLREAKKNRAGRPVNATWLDDAVRLRTAAAADTLLRYGARRQAPCRSRRELLGATAPKSPSLRRRQSTLCSAPDICRWLIKVRSRLRIGVSTSIRDSDVRGLAREPPGPTCVTCPSGKELSTLTQQALRFPCPSCDRVQVAASCWLSVLALAVWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ20</accession>
    <name>A0A398CQ20_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_05405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04532">
        <property type="protein sequence ID" value="RIE04532"/>
        <property type="gene ID" value="D3H35_05405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005690">
        <property type="entry name" value="GerBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="539" mass="60929" checksum="90729DD5BABC8430" modified="2018-12-05" version="1">METTEHGSMDLNRRDDFLSSLDKGDDEEKFRSSGEGKRGEERKRSAKISESDEIPDEIDEWKKRLKPALGLDASFDVQVREMTFGERRTAILFFSVFAKDSALTEILKRLTYLQPDNLSHDALEAFFEEYVPAIQIKRSSSFKEMIDEVLMGNTALYVDGVPAVLLIDAKTYPARMPDQPTLEKVVRGSRDGFVETLLMNVALIRRRLRDPKVRFEMMKVGERTQTDVTIGYIEDIADPKLVESVRDKIKAIQVDGIPLADKQLEELTVHKGMSQWSPFPLVRYTERPDVVAAQLLDGSITVIVDTSPSAILLPTTYFDLVQHAEENRQNPFMGTYLRWVRFLGIAASMFLMPIWFLYAQNPELRPPWLWFVGAQKTGQLPMIVQFLIAEIGVDLLRLAAVHTPAPLVTAMTLLSAILIGDIAVKTGLFVNEVILYMSVSAIGMFATPSYELGLANRIVRLVLLLAAWFFQVPGIVIGSTFIVLFLALERSFNAPYLWPFIPFNGKALLSIILRKPMPTNKSRPSINRPQIDDKQPNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ31</accession>
    <name>A0A398CQ31_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04635">
        <property type="protein sequence ID" value="RIE04635"/>
        <property type="gene ID" value="D3H35_03845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="250" mass="27227" checksum="77518D881FB9673E" modified="2018-12-05" version="1">MIAITGGKTMSIFTRFGSAALIAFLMLILSGCLYPDEQRAGANASAREAVLTVQDAVDRYKASTEVLPIVNADADVPIYEKFKLDFGKLQRTGYLASIPGIAFENGGTVVFIVIDEETKPQVKLMDVVVFQAVDGVQSRVNEYRKKHQGDNPAGEEAYPGFRTIDFGKLGGSEPKIRSMYSGQTLSLLVNDKGIVYVDYGIDISAALKKTDAAPGAEEDLRRRLVDASYYVPVKSPVYRWVGEAPQAVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ51</accession>
    <name>A0A398CQ51_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01104">
        <property type="protein sequence ID" value="RIE01104"/>
        <property type="gene ID" value="D3H35_22055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="121" mass="14260" checksum="9ECFDC2F9E4D5B30" modified="2018-12-05" version="1">MKKRSNDRSQCPIRLTESLIGGRWKTIILWLLSKRSMRFNELRRELSGITQKVLTEQLRELEEDRLIHRKVYEIVPAKVEYSLSGQGERLIPIVVMMCSWGEEYLSQELAREKLPQENSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ66</accession>
    <name>A0A398CQ66_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zf-HC2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04663">
        <property type="protein sequence ID" value="RIE04663"/>
        <property type="gene ID" value="D3H35_04015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="200" mass="22756" checksum="9ED2D09A79F7452B" modified="2018-12-05" version="1">MKCEQAEELFGVYWDLPEHAPERIMVDIHIQSCAACAEQFRMWEESSDLIRDIPDDDKLEEEIFAYQGMSDKVMNRIYSEQSWFLPTSRRTYSFTNGFRKKTAIVLAGLLTVFFGGFLYSTINRAIGPDSNITGVMETASAFAASHDLNNSVTIEVPTASLSEPYLLHVTPAMPEYWVALSMLGMIMTLLILNWFSRVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQA6</accession>
    <name>A0A398CQA6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03489">
        <property type="protein sequence ID" value="RIE03489"/>
        <property type="gene ID" value="D3H35_12640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="331" mass="36095" checksum="7F25827507B977ED" modified="2018-12-05" version="1">MEWDLSQPMTTWRTIVVSLEPFDTARQAVSSAGLETIVPPPVIVPPLTTGFHQVDISANIPEPGPGVLAVGVTLRAAPHPPSRPQAVTASTELSSRSGAAFVRLKLSPLEPLAYTCSTFIVTEDSRGIRQWDGLELARTEERLRLKPDDFPIRFVPIAVSPELLELATIRGRCEWLEANHSSASSAFVLDRDRPELAIAIPAAASNASFDFDVLSVEGDRSLHLGPFSAEPLLLGLHLFPEYGPQQISIELAEAASPSLVAIDLLPENREEMAEAVTVLALTRNQSKKSWSYLASSPFYPGFRYRKHAGADGSPEPWSEIQSPFERLVLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQG8</accession>
    <name>A0A398CQG8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05340</name>
        <name evidence="3" type="ORF">D3H35_05365</name>
        <name evidence="1" type="ORF">D3H35_22905</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000024">
        <property type="protein sequence ID" value="RIE04590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000024">
        <property type="protein sequence ID" value="RIE04592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01244">
        <property type="protein sequence ID" value="RIE01244"/>
        <property type="gene ID" value="D3H35_22905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04590">
        <property type="protein sequence ID" value="RIE04590"/>
        <property type="gene ID" value="D3H35_05340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04592">
        <property type="protein sequence ID" value="RIE04592"/>
        <property type="gene ID" value="D3H35_05365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="128" mass="14606" checksum="423DDB133C1644BC" modified="2018-12-05" version="1">MEDFRDIATDAHMALQEATQPFHLLIDNRFIVDKTVVNLDSMLKALPILEHTHLRWIVVVLPEAVKETAAVRQIQRHGSIQLKFVDSLTSAFQHLAREDDRIDGVVGMELSWSDWISYAENPIVTGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQH3</accession>
    <name>A0A398CQH3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_04415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04732">
        <property type="protein sequence ID" value="RIE04732"/>
        <property type="gene ID" value="D3H35_04415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017240224" evidence="1">
        <location>
            <begin position="36"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="2">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="2">
        <location>
            <begin position="75"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="244" mass="26827" checksum="B4A58E1C6B0EED56" modified="2018-12-05" version="1">MWRLSEVKRLKTKQGFVTAMLVAALSVSVPMNVFGAGALTEIKVFLNTGIKVIVEGKSFNPALEDGTKLVPITYKGSTYLPLRAVAEATGLKVSWDPNTSTAYLGKVEGDIAKEETSYIRASSEFVYNGEATYRLSSRTPEQLTTDDGTVFGFGYVTGGSRSVTIEVETKFAYSKFKAKIWSADSLTKDDLKIEIRDENNISVKELKVKNGGITELELDIKDTNALRIYVQGDKSIIGEPMLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQI4</accession>
    <name>A0A398CQI4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-antigen ligase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_15055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02077">
        <property type="protein sequence ID" value="RIE02077"/>
        <property type="gene ID" value="D3H35_15055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="823" mass="91734" checksum="2C362BC78ED7306C" modified="2018-12-05" version="1">MSKKTEKARPSDKGPISAKETIPLRYWAVVGLSVLFLFWAPFQRALFNGNDSTFERPIYQSIVCASLILFGLALLLLSKWKLRSEQGWLSVGFWLIPAAYLLSLANAASQLSALNALYSQFLYGSMFLIGLYVIKDGLGNRIFQSAILASGYFIVLFGLFHWLGNGEAISSLVGWFTPFVEQGVYKDAVMTDSNGLRLASVFQYANTYAAFLIALLLCALFFTIKSSGWKSASLHAVWVVPILVSFWLTLSRGAIVVIAVVLIMLLLFLKPYRQLLLIAHLIVGSILTFTILGKVTSYGISVHESFSASLSAKGWLLLLAATALYTAAACAMQRFLAPWLSSKLERIDGLKKGILLIPVIAVVAGSLVIAALTQVSAIRSLLPANVETRLENINLAQHSVLERGTFYKDAMKLVADYPLIGAGGGAWSALFEKYQSNPYVSRQAHSFFFQYLTEVGIIGFIVIAAFLVAVFYFYIRRYFQSDENQRESRFLYFILALSLLTHSAIDFDLSYLYLVVLLFLCLGGMASGLSKEPSTSPLLPKDTKRFPIFPAILAVGSIAVLILSARLVMANSSFKEHLAIRQSSNDFNELMDPLDKALKLQPGHPEYSAYSIDLLNAVYQQTQEAVYKQDEQSILKAALHREPHNRQLIEIQLNDLIANNDIGRALQRVREALPDFPWDMQLYEKSFQLEEALSQTARESGDTGTIDKYWQYMLADYEAIKRNIDHLSTLPKEQNQGLAFQVTPQIASVVGSNYYRHGDYLAAEEALKPYIGDDLTDETNVTIIRWYLASLSKQGKTDQNLYDRLTSNDPSEADKIAEIVNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQU8</accession>
    <name>A0A398CQU8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_03470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000021">
        <property type="protein sequence ID" value="RIE04925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04925">
        <property type="protein sequence ID" value="RIE04925"/>
        <property type="gene ID" value="D3H35_03470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="116" mass="12931" checksum="DE5B175FF46BA109" modified="2018-12-05" version="1">MSRNKKVWIPAMIAAAIAALLVVYYYWTSAHGGGEVRPRPLAGEGHRPPEDGNERYGGYFTTLGTIALYFGAAGFSWFWFKKKLRSPSRLVRQAGKLLLEPEPGETSRSEIEGNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQU9</accession>
    <name>A0A398CQU9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_13475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01801">
        <property type="protein sequence ID" value="RIE01801"/>
        <property type="gene ID" value="D3H35_13475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017260371" description="F5/8 type C domain-containing protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="51"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="176" mass="19066" checksum="EF98912C48B87CD7" modified="2018-12-05" version="1">MRLLKKGLVGKKVISAVAALAVVSGLSIISASAGSNIIPLMTSNSSIYGTAYASSEWATHDAYKAFDHDNSTYWSTSSGVYGELRFTFPTSKRVTSYTVRTSSEPLGNVPKTWTLQGSNNGSSWTVLATESNWLYPNFTYGPFLTTTSGDYTMYRLVITANNGAYSTSVAEVQMFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR06</accession>
    <name>A0A398CR06_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="2">PPIase</shortName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_13830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01861">
        <property type="protein sequence ID" value="RIE01861"/>
        <property type="gene ID" value="D3H35_13830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017101713" description="Peptidyl-prolyl cis-trans isomerase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="90"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="247" mass="26118" checksum="627B8B7B7F89FA37" modified="2018-12-05" version="1">MIKKPKLAVTAIVMIALLLALTTACGKRVETPAAEGTSTSSSGNGGAASSSPSAEPTPTPSPSSTDPLDNPNHSDQNPVVTIEMSTGKTITVELYPKVAPNTVNNFISLVKKGFYDGLIFHRVIPDFMIQGGDPEGTGMGGPGYGIKGEFSTNKFTNDLKHTRGVISMARSQSPDSAGSQFFIMVADSPFLDGQYAAFGQVLEGMDVADEIVRQNTADQDRPLDPMSMTKVTVDTKGVDYPEPETIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRG0</accession>
    <name>A0A398CRG0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04740">
        <property type="protein sequence ID" value="RIE04740"/>
        <property type="gene ID" value="D3H35_04460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1339"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1347"/>
            <end position="1382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1382" mass="146217" checksum="0F483BC91BB335D3" modified="2018-12-05" version="1">MDINALDQALVINAGSLTLTGTTLQGCPLQDILTTYNAGAPLTIENAQKQLTSDAVIVTGAASFLNVPNLKVEAAFTLDSAGNPIGSFVFLLIENGSVTSNPWTFGTSFPNLPDFPNFTESSYAANYSVLNRLVFSEASFILQTAAGIDSKTNVPLAYGLNFVSRVNPASLLGLMAPLLGSGTTILYGTITLPTPAQQTRPLPVLKEPWNELGWTVPGIHLQSALDFDFTLGKLTVEKPLFRIYSPISTDWLANNRTYQPEFALTSTMTVPSADIKLDLTTLFNPNQISIGGIFSGIQLDNLAHLTDFVQGSDLFSRLPADVQSIVSGLGGLSLTAAGLSLSGGISSSSVDSVYATVGFPDVKWTVFPGIDIEAVSAQFTVLEPFNQAGRSVNVTLQGTISFGGASFDVFTMYPGFTVQADLQHSTPVSLSGLFQQVLPELPVPPDLTISDMQIFVDPGKSYFFTATMLDKPAWQFDLGPFGLSIGNVQLTLNKQTGSPASGSFSGRLRIGSQLIVDAVYDLPGHFFVRAELPDLKLSQMIALFDQIGIKLPSGFEIELKQSYVLLSTESGGFTFTAATYISDIGLLAITAQKEGGRTGVAFGIQLDVARLCAVTGLEALKALDELVGLEQVMLLVSSLDQPGFQFPDMAHFQAPPLAGKNLKLPAQASGVVRGLNFYARLNTTKSQGFQALANYLDIPLDGSIGITVAVSMPDPSSNSKLFLSVTNRIDSVTTLTGDFGILMLHGQPGAFLTGHVDTQLQGSPIRFDVTAMVLANGVLISGTMLGSIQFGDLPVHLSNVALVIGMDWEGIPSFGFAATLDVQDFNSSIAVFFDSVDPSQSMFAGAISDLSLRDVATTLAGQDTLPSELTDVLTLIGLKSLKSFTMPSSCAADLDGRNLSAIASAFQQYGSKSIPSGSNSILLTINSAGSVWSLTDMTTMTHYRLTLEGDRISVGLEPQIYFAPTDTRIGSIPFNAGFHVEAAIDYLVIHAQLKISIDTSKGIAADASINPITIFNDTFFSVTSADGKTGPSLSLATYSQPDLPKELQGPHFLVSGNIRLLGLDISRTYISVGEDGLAFRVTEQVSPVVKLDVQGAFNSLTNLGVNGGIVVGFDEHLDLGQLGNIHFAANVDGQLSIGYKNDSAFASIQGGFHFGGVDCSIPALTLDVSGPALANIASTLWEQVKDIIEKLLTNPDQWLSWVKGGAVQLADQSAQAIGKILGDCYDYLSANDIASKTKEIMDYGIDEVTAALKGAGETAEEAVQALASVGFAAEEIGKAIVSVFSGIHVDTSFGHIDQSAPHLDTPQIHADVPSIHTDASTHADIGGHIDKGSGWLHIDTGAPHADTTPHVDQTITPHVDTDTPHVDTTPHVDTGTHIDVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRH5</accession>
    <name>A0A398CRH5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_02005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05165">
        <property type="protein sequence ID" value="RIE05165"/>
        <property type="gene ID" value="D3H35_02005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="144" mass="16952" checksum="2033699591368282" modified="2018-12-05" version="1">MSHSHTVQEMLAVMTRNGWRITDQRRTLVQIFADHDGYLSPKDVYDQMCVKYPSVSFDTVYRNLRMLSEMGVLEQFYFMEGGLKFRGSCVDHHHHHLICVNCEKTLTFDYCPMEQQMNLPGQYKILSHRFEVYGICESCQVQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRJ0</accession>
    <name>A0A398CRJ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_12040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03398">
        <property type="protein sequence ID" value="RIE03398"/>
        <property type="gene ID" value="D3H35_12040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="313"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="357"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="518" mass="58949" checksum="FDF8093D26E3A3BF" modified="2018-12-05" version="1">MSILTVKNLSHGFGDRAIFNDVSFRLLKGEHVGLIGANGEGKSTFMNIIMNKLEPDAGKIEWARKVRVGYLDQHSVLQQGMTIRDALKGAFRYLTDMEAEMNQMYEEMGNVTPERLEELLEEVGTIQDLLTNNDFYLIDAKVEEVANGLGLSDIGLERDVHDLSGGQRTKVLLAKLLLEKPDILLLDEPTNYLDEQHIEWLKRYLQNYENAFILVSHDIPFLNSVINLIYHMGNQELNRYVGDYDTFLHQHEAKKQQLESAYKKQQQEIADLKDFVARNKARVSTRNMAMSRQKKLDSMDIIELAKEKPKPEFRFKEARTSGRLIFEARNLVIGYGEPLSRSLDLKMERGQKIALVGANGIGKTTLLRSILGEIPALSGTVERGENQYIGYFEQEVKSGQDETCIEAVWKEFPSFTQFEVRAALAKCGLTTKHIESNISVLSGGEKAKVRLCKLINRETNLLVLDEPTNHLDVDAKDELKRALQAYKGSILLISHEPEFYRDVATDIWNCEAWTTKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRL2</accession>
    <name>A0A398CRL2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05205">
        <property type="protein sequence ID" value="RIE05205"/>
        <property type="gene ID" value="D3H35_01400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="7"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="369" mass="42696" checksum="394CF795CADAB0B5" modified="2018-12-05" version="1">MSASIVNILHLSDIHFGTEDNNKNPTAFAQRKNALIGLTNILERVEEHEKPDIVVISGDITWKGNADGYTQAAEWITEVLNKLNLTTSDLIICAGNHDIERRKTIGMNPPISSTEADEWLSFENLENFYRPFSNYSAFSQALNIPPLTINEYSNHLVGYRDHKGIRFVVLNSAWFCRSNDDARKLWLGLPQLQLLESKGIITRDSDENITISIVHHPSNWFNEEELQSYERPAAYKYLSERTHLILSGHVHAYIEKPNKMYDSAYAITNGASYAGNRLRNNFSIIQVNRSSFQINQIPFEYDPRSTEWERKRNTYLDIKKKALIESLPQQAQKKVFYVPYRKHPFFQGRIHELKKINNFLIPMNQCIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRM5</accession>
    <name>A0A398CRM5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_01510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05225">
        <property type="protein sequence ID" value="RIE05225"/>
        <property type="gene ID" value="D3H35_01510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="240" mass="25653" checksum="A830643AAF7AC429" modified="2018-12-05" version="1">MTPRTKEQNEEIRLLRLAQIRKAAADVFLNKGPLLEIRDVAAQAGLGYGTVYHYYSNKGDLLYELLWDALERAGEWLEVPRASASEEATAGGHFGWAAAADTGNSAAADSRIGSRETAAAAELGPVAAAGVRLLQLWAEDHALYLLHKLAGEGFASLPEARSTPLSTAFRREVLAPFVALLETGRAADEADASGGNAAEPPDRLQRAEMLLAALVGCASVSLRRGKLHEEARDIALLLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRT5</accession>
    <name>A0A398CRT5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isopentenyl-diphosphate delta-isomerase</fullName>
            <shortName evidence="6">IPP isomerase</shortName>
            <ecNumber evidence="6">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Isopentenyl diphosphate:dimethylallyl diphosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Type 2 isopentenyl diphosphate isomerase</fullName>
            <shortName evidence="6">IDI-2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fni</name>
        <name evidence="8" type="ORF">D3H35_08105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homooctamer. Dimer of tetramers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the IPP isomerase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03919">
        <property type="protein sequence ID" value="RIE03919"/>
        <property type="gene ID" value="D3H35_08105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02811">
        <property type="entry name" value="IDI-2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00354">
        <property type="entry name" value="Idi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011179">
        <property type="entry name" value="IPdP_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43665">
        <property type="entry name" value="PTHR43665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003314">
        <property type="entry name" value="IPP_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02151">
        <property type="entry name" value="IPP_isom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_dh" evidence="7">
        <location>
            <begin position="9"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_dh" evidence="7">
        <location>
            <begin position="179"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="100"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="70"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="348" mass="36994" checksum="CDF95407CFB5A5EC" modified="2018-12-05" version="1">MNEKEKSTATRKSDHIRICLDEQVSGQGVTTGFEHYRFRHSALPELSLSETELSVDLLGKKLKTPLLISSMTGGTEQTGAINRRLAEAAEARGWGIALGSMRAAIEREELASTFRVRKQAPTTLVIANLGAVQLNYGLGPEDCRRAVALAEADALVLHLNALQEAFQPGGDTDFGGLLRRIEEVCRRLSVPVGIKEVGWGIDSDTARRLTDAGAAFIDVAGAGGTSWSQVEKLRQSDPVVRAAAEAFVDWGNPTAECVREVREVLPGAVIIASGGLASGVDAAKALALGANAAGFGRSLLRQAAVPGGDVALDLERIELELRTAMFGIGARNVASLQATDRLYRRILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS46</accession>
    <name>A0A398CS46_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_13250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01764">
        <property type="protein sequence ID" value="RIE01764"/>
        <property type="gene ID" value="D3H35_13250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="225" mass="25056" checksum="95BB2693680C5860" modified="2018-12-05" version="1">MRILIVEDEVHLAEALTQILKKHHYSVDAVHDGQSGLDNALSGIYDLLLLDIMLPEMDGITILKTIRSQGISTPVILLTAKGEISDKISGLDYGADDYVSKPFSTEELLARIRAALRRKGEVVPEDALKLGDIELNTGTLKLTCRGKELKLILKESELLELLMSRKNAVASKEQIIEKLWGFDSEVEHNNVEVYISFLRKKLSFLNSSVRINTIRGVGYVLEATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSA9</accession>
    <name>A0A398CSA9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_10575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000033">
        <property type="protein sequence ID" value="RIE03628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03628">
        <property type="protein sequence ID" value="RIE03628"/>
        <property type="gene ID" value="D3H35_10575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="354"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="457" mass="52042" checksum="6EDAFF1FAFC36DB7" modified="2018-12-05" version="1">MTGHARFEYAQEALQYGCFDYVLKPVDHDVLKEIVKRAIEEIERRQERQAFEEMLEKYRRHWKNQLPILVEKFWQEVLAGRGPAGQDRLDREFAMYDIPLSAGDRVLPVLLSIEQWDVELDARDESIMEYAVRKAAAEIILGDRKGAVLQDRNDVNLVLVYLPDGALADRDALKTACLQYVRASNDYFHCRVSCYVGDTVRIGEIAGSVERLSQLERANISNPQTVVDGLESGEALGGSAAGPSLPSFMEWGILLDNGSIDELVLAVNETLRRFQEESVSRETLELFYFGFVHMLFQAAHRKGVSIYDALAVQEMNDGQFARTPLHMQAWAVKMVQKAGQAFQDRHRDASAVIAKIQSFIQDNIHKELGRDDIAGAVYRNPAYLSRMFRKETGLSLTDYIAQAKIERAKRLLIDTNDKVSHIAEGIGYTHFSYFAKLFKKMTGMTPQDYRKKHQTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSI6</accession>
    <name>A0A398CSI6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02341">
        <property type="protein sequence ID" value="RIE02341"/>
        <property type="gene ID" value="D3H35_16625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="108" mass="12087" checksum="BB5942C6B7FF4E0C" modified="2018-12-05" version="1">MLQQTEERLPGKTRTIGLASDARLRCRSVVRERLTGIRMRSFGRVTGSGWATRAANFRMEELTGLGWATRAVNVRMEELTGYGWATRAANLRTEELTGLGWATRATDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSU7</accession>
    <name>A0A398CSU7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ppx/GppA family phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02887">
        <property type="protein sequence ID" value="RIE02887"/>
        <property type="gene ID" value="D3H35_19925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030673">
        <property type="entry name" value="PyroPPase_GppA_Ppx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001267">
        <property type="entry name" value="Pyrophosphatase_GppA_Ppx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="30"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="510" mass="55919" checksum="04CA38C46518A214" modified="2018-12-05" version="1">MGSSSVTGIIDIGSNTVRLGVYQLTEGGAHRVIDQGRFAARLSQRLTPEGLLPEEAVEELVEVLRHYRQICLKHGATRIRAVATAAIRQAANRDNLLRYLKAATGVEVELLSGDEEARIGSEAMTRTMNVQDGFVVDIGGGSTELSLLRDGRLVSSVSFPIGCVNTAGRHALGDDPVPLTKLQDMQEEMRALLQRHSWTTQHPGLALIGLGGTVRALAKLRQRESDYPFPLLHGYEMSDSEVEDSLHKLADIPVDKRRKLPGLSKDRGDVIVPGLALLLAVIREIGSTRLIVCGAGLRDGLFLETCVPRSRRETDETAAAGERVNQVLEESIRNLTALYPTAPEEHLSQVSRLAVTMFDVLAPDREIPSDMRLLLASAARLFRIGAVIDFNNCADHTFYMLVHTHWNGMSHREILLTAAIASYRGTNSLRRQLSPYRSILSEGDMEAVSKLGALLQLASALDRSESQAIRSLEMVILSGKLLLAALADHPLPVERLEVESLGKDFRKAWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT85</accession>
    <name>A0A398CT85_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04469">
        <property type="protein sequence ID" value="RIE04469"/>
        <property type="gene ID" value="D3H35_07765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="36"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="277" mass="30064" checksum="B17EB3A63E4A8EC7" modified="2018-12-05" version="1">MADEKIDELPLLEWDVEGPDGSLHLIGCGDPKGRPVLFLHGITENARAFEPAMRKLPDGIFAAAMDLRGRGLSAKPMSGYRLANYTEDLLAVCNGWSGKAPVIVGHSMGARVAAAFAALYPGLVGGVLLIDPPLSGPGQTPFPVPLSRFVEPKRALERGDMATFRSYYTSPDFDYERKARELGGCSLEAIEQSHAAMNTDPFHAYYRMLSVPALLVAAGGAPFISMEAEMQLREINPRVRTARLEGIGHEIHKLAPALFLQTVRDFLTSMDNEGARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTJ0</accession>
    <name>A0A398CTJ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1128 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02631">
        <property type="protein sequence ID" value="RIE02631"/>
        <property type="gene ID" value="D3H35_18290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009507">
        <property type="entry name" value="UPF0435"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06569">
        <property type="entry name" value="DUF1128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="73" mass="8123" checksum="979E1F0FC1CFF62B" modified="2018-12-05" version="1">MDLSNPTQANVEYMIEAIKTKLRMATGAAMQASSFSIGKYEDIKDIYDMIDSKDRFSISEVEAIVSELGKLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTR0</accession>
    <name>A0A398CTR0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_09145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04098">
        <property type="protein sequence ID" value="RIE04098"/>
        <property type="gene ID" value="D3H35_09145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="21"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="220"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="415" mass="47234" checksum="15A67092E6643DB9" modified="2018-12-05" version="1">MKILLATFWPIPQAGRIWPFMLQLKAQLERRGHTVDLLGSGVDEDNVYAYIVNEDRRIYLNKLLPLLKSRDSPHLSPSRQDNDLIGFAENRRSLYELSAVYLGLDDYDLIHTQDFISTSCIHRVRPAKSAIVATFHSSVAHEIRRHLRTSGNPETELLARALYNDLERNSVPDAEVMHVPNFWLRDILTGELRLPKEQIRVFQYGYDTDSFMNPAVSAERIQKPAGKKVILYIGKLVELKGLRFLIDALSSLKKIRKDWVLWIVGEGERQAHLREKSAVANLGDDIVFWGKKDNVLPFLKRADIFVLPSLIENQPLALIEAQLMGIPSVVSDVGGLPEMVRDGKTGLLVPPEDPDALCNQLNLLLADNRLRLRMGAKAKSHALVHWSLDQMILRILDAYREALNKRKEAGRHRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTT9</accession>
    <name>A0A398CTT9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04128">
        <property type="protein sequence ID" value="RIE04128"/>
        <property type="gene ID" value="D3H35_08270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="140" mass="15070" checksum="A5F8AE76990C4084" modified="2018-12-05" version="1">MALLAGRTFAVADRVPGIAGEAFDFGEWYSAAVVKRSRADGREPATLTHLSVRAADEFEAVIPLEQLGAALFQYRIDGLPLDKGKPIRLYVPDGSSACLNVKSVVTIGLVSDPTLGEEAAYGFRNEITPAGMMELRKSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV00</accession>
    <name>A0A398CV00_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02844">
        <property type="protein sequence ID" value="RIE02844"/>
        <property type="gene ID" value="D3H35_19640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="135" mass="15170" checksum="035BCDAF929D2015" modified="2018-12-05" version="1">MTAVSEEGRNQAKLETECKVAGRSCQQREGWELEVTAVSGEGRHEAKLETECKVTGRSCQQSEDWELAMTAVSKEGRNQAKLETEMQGYRDNMPAKLGRRACTSRYVVSHKSQLSTRTVRNGHFSSNLMGERFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV22</accession>
    <name>A0A398CV22_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_19825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02874">
        <property type="protein sequence ID" value="RIE02874"/>
        <property type="gene ID" value="D3H35_19825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="71" mass="8182" checksum="D86E2E4970EA09EC" modified="2018-12-05" version="1">MKGSDHKSKFLLTNREREVFELLVQDKTTRDIAQQLFISEKTVRNHISNVMQKLNVKGRSQAVVELIKLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV39</accession>
    <name>A0A398CV39_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_01905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05149">
        <property type="protein sequence ID" value="RIE05149"/>
        <property type="gene ID" value="D3H35_01905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="6"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="281" mass="31129" checksum="988FAA8B2629ABAE" modified="2018-12-05" version="1">MSRIFDCHTHLFGPGMVKGPTDAAIKRAWGSSMNIEATPEQHRVHMEGYSGAIVLAMAAHATGLVVPNEYVAEYCASDPDRLFGFASVDPNDPNGVAEFETAIRELNLKGLKLGPIYQNFYPDAKEHFALYAKAQELNVPILWHQGTSFVPEGYLDASRPAMLDPIARAFPNLKMIVAHMGHPWIDECISVVRKHPNMYMDVSALGSRPWQFYNALVSAVEYGVQDKILFGSDYPFFTTGKMIDSLRAINHLAEGTNLPRVPEEFVEAIIHRDTPGILGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV85</accession>
    <name>A0A398CV85_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-layer homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_20270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02944">
        <property type="protein sequence ID" value="RIE02944"/>
        <property type="gene ID" value="D3H35_20270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017373605" evidence="2">
        <location>
            <begin position="43"/>
            <end position="2546"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="2357"/>
            <end position="2416"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="2417"/>
            <end position="2480"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="2488"/>
            <end position="2546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="878"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="2546" mass="273553" checksum="F4B8D2EB8CF2D87F" modified="2018-12-05" version="1">MKTGLGGKISFMTKMRKRLIAIIVHTLLAAFIMNMVPAAALAAELRQSGVTEIANEFIKITVDNTSGRFGIRTVEGQPIRKKDQNVNMLFGGDDPQTSFTTFRIDGTDYIFGNPYKFAADFFSEVEQPRIVDNIDGTRQIETVWRIKGVSIKQILMLYTRSSDRDNAGNVNIRYEVVNHSGADVQIGSRLLLDTMVGGNDGPAFQIGTSYNAPLMVERKLVHNPEDDPSIAEGERALYKLPPYWVMRDKLSPTNPLATQVIAYGLNNFSENNVNIVDEMIVGHWNSLANTKWDYTVNPNLDFTRDTNDYGTADSAVAFYWNPDRIATGSSKSFETVYGLGELVQPDKVFSIRYMDTAEQLATLDDGSAYKDEGIFDIIAEVENLQSFQMEHSGIELELALEGGLDFVQVDERGNVVRDEDGKAVTTPYRSAKLTFRKEATPEEASQGIQPKYKPGESVTASFKVKAKGNPWPSVKEYMLTAKSPETERKVESIEDEGIKAEYVSSKGGFILLPPVGEATPTYVYGLSPEEAYRDDEKYITVNLSNIEAYHAGNANIEPNFDLFFKEVLTGKRYKVPVRDSVLIQPTDEGLTGDMRITYRTGDLVDDYGNVLTANLGPELPLGQYQVQIDYKGGTGADEEAASIYDITSKQTFLVTDNQKARIREAKILTVTKTTLDLRVNAINAVVNTDEKLAEINRAYPNYNVSSIGQLAADVTAFAAFKTSLVAASKAIDPAYEESGLLDFENVAAYRIETFQSEAELQQSKASGDEMLVEIRGMIKQIGSGDQAEYVVDTKTEPALINKTVAYKGKDIVFVKGRLEALGLSSGLPFVSTLTVKGEGDLKIANSGFLFYRGEWTLDFYNSFKKSFRLSEEEQAAQDEAARQKLAEEKKKKAESNPEDSSLNGALKWAAGAARERMNPLRQINIDSVYFNKYSMYATPGFSISGLSLALSDFLLREDGVSFAGTLNLKVLEAEVKDVLFNDKGFVGVDTALKFNLEKDMGLLKSQNTETTGPDGKKQVVKGTGPTGDVSGEINVTHYVQSVEGISNKYGLKFNAELKSIATINAEIGFKQVADGRILPDVIAFGAEDMDPGIMIAGATYLTGVRGAIRELADTIAGGSDGVPLTLEAGVDVSFGLPPATFYGSIDLMLKMSGIKLEGKLDYAPSSNSERVEMLTMALIEAQWMTPWFVRAEAELDVFGWDVIIGNARIFVGQNLEKNRIDFEGFVGAKVQIPSDVPIVGGIPIGSVFMGLNNDKIWGGVGIGIGFIMIQVGITYYWSGDLEFGTSGEGLPDGLAYLQVQNPEGRPKLVVIGQGIKPVATSWTSREDQIHEITYRSAGEGISILDNGAMDIGIGGITVSNGGKNHVLPMESVTGNALLEVEYFEDTVPELILQDKAAGTSYPVVYYEAGATATQGSVREKGHLPGYTQFIPGSASEGTYDRRKAYIAIPKEVISGGSWTLYSSRSVESKLLDVPLPSTLDEVKLVRDGSNANVFTASWKASNVKQGDTVNLYLTKDAITGQKDTVADSNGHTYDVPAAKDPGVLIAKDLPVGATGVGSTTIDVSQVSLLGSTEDLRGLIKQGDYYLRAELRSVSNFATKTSADKFRIVDPLAPQATGEVEIVPAGNGYFELSFKPGAVKAGQEDYPRSFHIDALRDDADGELSPYANFGTVVLEGEELQKYWNPSTGRYEHIRLGGWTAMSTSNEVDHGTLAGSAGDEPVKYRGLETGKVYAVGVTASVKPPKSADKNENWHFASRVDSVRTLLPAPQKPKLTALTGTTGAAGKSVAVLTSDTAQSIELVSDQQDVRVEAIYSDKIVAGLELANKAGGSKGVLNLSDFSTDGTYGIELKAINKHTGDFSITMLYLTVDTTAPVIYIDKPKTGDRTANGSIAVSGTTSSDAVLTVNGTVIPVETNGAFSGTVPVTGDEAKVKLNFAAVDGVGNRNEAVVDVTNDGFKAPVALVLRKPAAMKLGDSKSVEAFLRYPDGKDGAGKARYKEVPVPGEDMDKLSFSIYMGEAVRVDEEGELQAVKFGSGIVSASFRVSEDAVLSAMTAVSVPGQLEAIAASSSIIDNAADKTRINIANAGNMDGAELVYKTGAEVPELYDDLSAWSLLPASMAIPAADGVSVVIAKRSSDDKLALGASSKIAAQVWKFTGGGGIGGGGFPGVPESPQETVDVLVNGNPVAGQKAEGIVSIPIEGKDLGAGEIGISANDKTAHSFIFNMDKDVREDQDIRLETPIASVLLRANAFISGANGFQVKISKNTDTDAQKLGEIAAGLHAALLGQGATFDIPAREDRYTTVRMPVPDHVVARDITAVILKDSDGSWTTVPWKLDIVGDKAYVEASIAGNGSIAFIGSQSSFNDVKPGFWGKKSIDEAAAKLFVVGKGNGTFKPNSEVTRAELVTVMLKVAGLMNKTATANFSDVNSKDWFWRSAAIASEKGIVSGYEDHTFRPNGKVTRLQAMVMAGRVLEYAGVISSISDEEAKQIVSRFADGASLPEWARKAAALCIKNGVIAGSGAGLDAAGLLTRAQAAAIAMRLDKLVTPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV89</accession>
    <name>A0A398CV89_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Antibiotic acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_09645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03807">
        <property type="protein sequence ID" value="RIE03807"/>
        <property type="gene ID" value="D3H35_09645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="240" mass="26032" checksum="F10C6E1F08C93BC2" modified="2018-12-05" version="1">MLDNAKRKAALLLHRFLQYWTTRAVKEQPRIDPTVYVMPNAYVSAEVAVGRYSYIRGGAQLESGSVGAFCSIAPDVLIGGDEHPLDAVSTHPFWYSPGGLTVPTGPGEDGGASLWSQPKPAPIIGNDVWIGAGAKVMRGAVIEDGAVIGAGAIVTGHIPAYAIAVGIPAKVVRYRFEPAQCERLRQTRWWEWPEAKIRENRRLFGDADAFLSGFEDEQRSSEESGRETGRLNGIRKGAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW47</accession>
    <name>A0A398CW47_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxygen sensor histidine kinase NreB</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nitrogen regulation protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D3H35_12260</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03431">
        <property type="protein sequence ID" value="RIE03431"/>
        <property type="gene ID" value="D3H35_12260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="PAS" evidence="15">
        <location>
            <begin position="39"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="16">
        <location>
            <begin position="117"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="284"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RIE03431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="372" mass="41569" checksum="1E52E847D40004DD" modified="2018-12-05" version="1">MSDTASLNPFGPESSAAHVASLLAEFDAQVEDEAIRVRLKNSLKQLVDVKLALDEASIVAVTDRKGKIQYVNDKFCAISGYGRDELLGEDHRIINSGHHDKSFMRELWSTISSGRVWRGDIKNRAKDGRYYWVNTTIVPFVGDGGEPYQYLAIRHEVTRLKETEEELQTMVSQIMHIQEEQRKQFSRDLHDGIGQSLFSLKISLDRMISDNDSPDLNALRQDVTQLMTEVRGLAWEMRPSVLDDLGVVPALRTYTEHISRYYGIHVRFDSELSARPPLSAETTIYRVVQEALTNIGKYARASEAVVALRERDDLIEAVVSDDGIGFNKESKGSGVGLFGMEERARAVSGELSIVSSPGQGTTVKLVIPVVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW95</accession>
    <name>A0A398CW95_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Flagellar motor switch phosphatase FliY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fliY</name>
        <name evidence="10" type="ORF">D3H35_11430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliN/MopA/SpaO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03294">
        <property type="protein sequence ID" value="RIE03294"/>
        <property type="gene ID" value="D3H35_11430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007597">
        <property type="entry name" value="CheC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012826">
        <property type="entry name" value="FliN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001172">
        <property type="entry name" value="FliN_T3SS_HrcQb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04509">
        <property type="entry name" value="CheC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00956">
        <property type="entry name" value="FLGMOTORFLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02480">
        <property type="entry name" value="fliN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheC" evidence="9">
        <location>
            <begin position="47"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="CheC" evidence="9">
        <location>
            <begin position="143"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="FliMN_C" evidence="8">
        <location>
            <begin position="329"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="237"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="409" mass="43379" checksum="8349E023FC055115" modified="2018-12-05" version="1">MTSKDYLSQEEIDALLKQSSGGGAEQPESFGSGDGSIGIEDLLTPLEQDALGEIGNITFGSAATALSTLLGKKVDITTPTVSAIARSRFEEEFPKPHVAVHVHYVEGFEGINSLVIKAHDAQVIADLMLGGEGNVTSTELNEIHISAVQEAMNQMMGSSATSMSTIFNRMVNISPPGIDILDVQNGSGVSNIPAEDYFVKISFRLKIGDLIDSTIMQLVSVPFAKDLVNSLLGGTSSEPAPAPAAQASAAPAPQPTYQAPAPTYQPPSQPAPQPAPNYGGYGAPVPQMPSQPQTLGAAATHRNVNVNPVQFASFQNSGFSQAEETNLNLLLDIPLKVTVELGRTQKQIKEILELSQGSIIELDKLAGEPVDILVNSKLIAKGEVVVIDENFGVRVTDIVSQWDRVQKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWL0</accession>
    <name>A0A398CWL0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor SigA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpoD</name>
        <name evidence="6" type="synonym">sigA</name>
        <name evidence="11" type="ORF">D3H35_06250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04217">
        <property type="protein sequence ID" value="RIE04217"/>
        <property type="gene ID" value="D3H35_06250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007127">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042189">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03979">
        <property type="entry name" value="Sigma70_r1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="9">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="10">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="6">
        <location>
            <begin position="145"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="6">
        <location>
            <begin position="224"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="6">
        <location>
            <begin position="313"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="6">
        <location>
            <begin position="169"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE04217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="378" mass="43331" checksum="CF22B717A2FA1EF4" modified="2018-12-05" version="1">MANDQHTGLDTELTLEQVKAQLLDQGKKKASLTYKDIMEKLSPFDQDPEQIDEFFEQLADLGIEVVNDHDELGRHGEEDRDRDNQDEFNFDDDLSLPPGIKINDPVRMYLKEIGRVPLLGADDEVELAKKIEIGGYDGEEAKKRLAEANLRLVVSIAKRYVGRGMLFLDLIQEGNMGLLKAVEKFDHTKGYKFSTYATWWIRQAITRAIADQARTIRIPVHMVETINKLIRVSRQLLQELGREPTPEEIAEQMELSVDKVREIMKIAQEPVSLETPIGEEDDSHLGDFIEDQEALAPADAAAYELLKEQLEDVLDTLTEREENVLRLRFGLDDGRTRTLEEVGKVFGVTRERIRQIEAKALRKLRHPSRSKRLKDFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWM3</accession>
    <name>A0A398CWM3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class A beta-lactamase-related serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_03255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04968">
        <property type="protein sequence ID" value="RIE04968"/>
        <property type="gene ID" value="D3H35_03255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017391602" evidence="2">
        <location>
            <begin position="36"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="3">
        <location>
            <begin position="53"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="524" mass="59973" checksum="F346E706FC47E724" modified="2018-12-05" version="1">MIKNKVSHAKKKRSLKKFLIGTVLLTWTILTSTVASGEELSQYGLADEKIQKIDRLVRDEMKRNHAPGLALSIVMNNKTVYQKSYGFANLEKKIPVTDDTLFEIGSNTKAFTAIAVMQLSDKGLIDLTDPVQKYIPWLKMKYSGQIANITIEQLLHHTSGIPFESIGDIPVSSDNKSLEITVRKLTNHELKFAPGEVFEYATINYAILGLIIQTVSGQSYEDYMKEYILNPLELDNTYFFIDKTKKHLKAQGYKFGFNKPMAFDPPYYRGNAPSSNMVSNLHDMDHWLKIQLETDNSQPLYKFIKESQNSPKLSKDLQYGMGWNIAGNGAVLFHNGSTPSFSSFIVLHPEERLGIVVLSNSLSTFTDPLGKVIDAIIHGGFPEQAPMIENDYYVGLDKTYSMVTYIVSPIAMLVLFLLARMLYRMATKQRFFSGFNSRFYISTAILFFYISAFSLLFYSLPDLLFRKLPWRFVIVWAPYSIYAALILIYSLINLSFVYFWLRYIFKVKRKLNEISSVSSWEDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWN0</accession>
    <name>A0A398CWN0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LytR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_06365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04237">
        <property type="protein sequence ID" value="RIE04237"/>
        <property type="gene ID" value="D3H35_06365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="106"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="371" mass="41014" checksum="AB8286AC388B0284" modified="2018-12-05" version="1">MSENSALPPRRSSKPAAGSSKKAKKTKKPRRWLRILFTLFGLVIVGLAVYVGSLVNEANKALGKVAAKPGTAAGDTPLNDADKAQVKPIALLLLGLDYRHETGSKNTDVIMTAVFNPKSKTATVVSVPRDSLLGVANYKKHKANAYYANFLSIARSKEKLKDDDADQYAREQTRELMSKFFEIPIDYTAVIDFQGFVDVVDALGGVDVYVDQNMIYKDNADGTDINLKKGDQELNGIDALGFVRYRKSNHGKTPESSDFERNDRQSRVLGAIIDRMKSFGSLPKFDNVIEAVGENMRSDIPKAQITNMLTTYFGISKQNVRFIALEGTWRSPYVYLDEAKLEEAKKALEEERQPTGRALTSTDEASQAAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXJ4</accession>
    <name>A0A398CXJ4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine kinase</fullName>
            <ecNumber evidence="1">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_10430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03704">
        <property type="protein sequence ID" value="RIE03704"/>
        <property type="gene ID" value="D3H35_10430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="483"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="598" mass="65635" checksum="67F379DBE04743DF" modified="2018-12-05" version="1">MKLSVGKTMLQLGWAVIFAMAASVFILSKWKGYSLLRTDCGYVEHCASSLQMTARFADELSGYGLSTEFYGGLVTAFMTIAGLASLAVGALLFRYGRKDVYCMTASLFLIITGTIFTTVEQSLEGSFPTVYGWFIVLNGIGSYYLPFLFLFPDGRFVPKWTVAPSVIWAGTQTIRHFIPGTWEELNWSPLFMTALVILTHGPLLVTIRRRYSSAASAQEKRQLKWFCFSVLAYLGTGLCLALPYVMGSGLALLVVQVAFFAGLLFWPFSIGVGMMNRRMGAGAVVLQRAIVMSTLSVLIALLYASVVGGFSLFVRDMSLLVSMAACGLAAMLAHPLYVRLQRGMNRLVYGESENPYKTLTKLAARLDDMSGQHAIWPEAVAGIALALQAPYAALVLHSEKGRTELASYGTIRLPVTEIALNRLEESLGALVLGGLPQQGETAADTAELLKHLTHQLSVAIHSARLADELQQSRERLVTAREEERRRLRRDLHDGLGAGLATVLLKADTVADSYEGDARLHRQLTDIQSGIEEAIADIRRLVHALRPPALDELGLVSALCEMAIRFQEGGVRVAVERTAGFPGCTQPQRRRYTESCRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXL3</accession>
    <name>A0A398CXL3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA starvation/stationary phase protection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_10545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Dps family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03724">
        <property type="protein sequence ID" value="RIE03724"/>
        <property type="gene ID" value="D3H35_10545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016722">
        <property type="term" value="F:oxidoreductase activity, acting on metal ions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01043">
        <property type="entry name" value="DPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002177">
        <property type="entry name" value="DPS_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023188">
        <property type="entry name" value="DPS_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932">
        <property type="entry name" value="PTHR42932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005900">
        <property type="entry name" value="Dps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01346">
        <property type="entry name" value="HELNAPAPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00818">
        <property type="entry name" value="DPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00819">
        <property type="entry name" value="DPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="3">
        <location>
            <begin position="6"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="144" mass="16267" checksum="599FACB85EC0BD1F" modified="2018-12-05" version="1">MELNQRINKQIADWNIMFVKLHNFHWYVTGEQFFTLHVKFEELYNEAALHIDVLAERLLALGGKPHATMKKYLSESTIGEASGEEAARDMVAAIVEDFGQLIADLKEGMSEAQEAGDETTGDMLLAIHSGLEKHVWMLKSYLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXZ1</accession>
    <name>A0A398CXZ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09105</name>
        <name evidence="1" type="ORF">D3H35_25285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000041">
        <property type="protein sequence ID" value="RIE00995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00995">
        <property type="protein sequence ID" value="RIE00995"/>
        <property type="gene ID" value="D3H35_25285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04091">
        <property type="protein sequence ID" value="RIE04091"/>
        <property type="gene ID" value="D3H35_09105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="81" mass="8907" checksum="E5CBE5FDF19618AD" modified="2018-12-05" version="1">MPNQAMQGASPMTAKELEYAADSMSNEDLLIKQCAVAAATIQNQQLQQMCAHMVDVHSQHYQTLIGMVQQHQPLAPTQPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY65</accession>
    <name>A0A398CY65_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0637 protein D3H35_00175</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0637 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000002">
        <property type="protein sequence ID" value="RIE05478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05478">
        <property type="protein sequence ID" value="RIE05478"/>
        <property type="gene ID" value="D3H35_00175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01851">
        <property type="entry name" value="UPF0637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009403">
        <property type="entry name" value="UPF0637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06335">
        <property type="entry name" value="DUF1054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021332">
        <property type="entry name" value="DUF1054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="215" mass="23991" checksum="F56664A5D16EE55E" modified="2018-12-05" version="1">MSATELTSSFGGFVPADFEVFDIDGLEPRMTALIEQVRPKLHQLGDQLSPFLSDLCGETVYPHVAKHARRTINPPNDTWVAYAPSKRGYKALPHFQIGLWGSHIFIQFAIIYECESKGAFAERALAELASVRRSIPASFVWSKDHMIPEGLRHGKLADEELADLFYRLGSVKAAELTCGIHIQKDDPIVSDESAFLALAEKTFKKLKPLYRMAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYD7</accession>
    <name>A0A398CYD7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04241">
        <property type="protein sequence ID" value="RIE04241"/>
        <property type="gene ID" value="D3H35_06390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017426898" evidence="1">
        <location>
            <begin position="27"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="438" mass="48924" checksum="A878E496AE6228CF" modified="2018-12-05" version="1">MTRRKFALLFLLLGFMTLVLAPWATAPSAIVLPRTEPDNGTVVSAAPNLNNDPVRIRVSVGLDEQEFDQLQEQNAGWSTRHPDIQVELSRVEPEDAYRAFKESSRLGEAADVMLLQNEWVREYAASGYLLTADAAFVGEALAEQFDALTASLKWNGYIWGVPRDFDPYVLVWNREALRKVLGDEATVPLTLQQWTALTAKASESGEGISWLAISNRDPFAILSWLESATGIRTDSVWENKNGPWSSEPWATALSLLNHAKEGIAFGQDASFVERQLLEEKALIGLLPNSEAVKLTERDLTSRSSGVKLIVDRSRWKLPFVWPRGRSYVVSSGTEAEDAARQWIVGMTGTENQLLNEKQFAKLPVYRSLFRTGTSLHGLLPEDSANSFPYQAPVMNGPELPERLDRLSELWYGFAASGLTADEWISRWSEESADFQLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYS1</accession>
    <name>A0A398CYS1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000028">
        <property type="protein sequence ID" value="RIE04144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04144">
        <property type="protein sequence ID" value="RIE04144"/>
        <property type="gene ID" value="D3H35_07800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="194" mass="21449" checksum="A69F75AD71E56B45" modified="2018-12-05" version="1">MVGEYPVIVLITVRRYPPGRYVRHVFIVISGSLFSARRHYFLRGVLVVQGEASSSAASPSATSSAQQSSADEWLTKAEDAAKQLKKYGFELNLNQKMSGESAGSNSTVKLDMQGRAELGPLKLDQTNKSDIDGEKSSLRAILVPDAYYMYSDEFKEWSKLSKEETANVVRTLSSLQINLAESIEGVRGWAAHWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZU9</accession>
    <name>A0A398CZU9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_00965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05387">
        <property type="protein sequence ID" value="RIE05387"/>
        <property type="gene ID" value="D3H35_00965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="319" mass="34827" checksum="E969ECCA69B8F450" modified="2018-12-05" version="1">MLQNVSVVFKQGTTTALVGPSGGGKSTLLKLVLGLYEPEAGDIRIGSVAIDRQTLGTWRKKTAYVPQDTTLFDASVFDNIRVGRLNATPEEIRFHYDRLRLSARRFLDGAFPPRSCLTLRSHRYETDSLLLPTASAAGRPAGPALPHRAGRAGYSPQRVPLFAGGCAPSERSGYRDHSVRRIGWRAIRHSLASYRQLGIGVRQQSGDPLSVLRDAHCACTPRRGRLRIGAARSDGRRTSRHCKRPDGNEGSGRAREGRLHRAEPGMRIGWPKAIAGLKRNEEARKAMGAAAAAKAKQYDASACADRYAEALRPAWVNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D037</accession>
    <name>A0A398D037_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage V sporulation protein AA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_05415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04534">
        <property type="protein sequence ID" value="RIE04534"/>
        <property type="gene ID" value="D3H35_05415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021997">
        <property type="entry name" value="SporV_AA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038548">
        <property type="entry name" value="SporV_AA_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12164">
        <property type="entry name" value="SporV_AA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="SporV_AA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="211" mass="23994" checksum="E385F618D98E839E" modified="2018-12-05" version="1">MPSVVYVRLRRRVVARPESLVTLGDVARLVTDEAAERRLKGLPIHQIASKDGSLLLIDMLQVVKAIREAEPGITIEVFGEPHVLLEITPSGDEVKPRLALLALAWVLLFFGSGMAIMNFHADVDMAVVQQRIAELITGKKAVHPWLFQIPYSFGVGLGMLLFFNRLLRKRLNDEPNPLEVEMFMYQENVNHYVITEEYRKKHEEEANKPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0P6</accession>
    <name>A0A398D0P6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_02770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05071">
        <property type="protein sequence ID" value="RIE05071"/>
        <property type="gene ID" value="D3H35_02770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="194" mass="18733" checksum="282CED142CD5923D" modified="2018-12-05" version="1">MIEIATVGGGTIQSAGNVVESATVGRGTIHSAGSVIEIATVGGGTIQSADSAVESATVGRGTIHSAGSAVESATVGRGTIHSADSAVESATVGRGTIHSAGSVIERATVGGGTIHSADSAVECATVGRGTLHSADSAVESATVGRGTIQSAGNVVERATVGGGTIHSAESVIELARGCPKNKLGQPLLHDAICA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D165</accession>
    <name>A0A398D165_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05231">
        <property type="protein sequence ID" value="RIE05231"/>
        <property type="gene ID" value="D3H35_01540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="164" mass="18497" checksum="1C65B0962C95DD19" modified="2018-12-05" version="1">MNSDAANDHRQFYKGGIQAIYKRIGSYLPDHYPLGDNADQTLDFSDLRQSTYGTVMFTTDFGCSACKLEPVIAFAERYPFFNYRLFLHNGDETLERMKELRSLGMPIEVCHLGDIAPILSSLAPAAFAINSQLQIVSCGIYRDLDDLEQIAYPFIRVSKKSVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1H8</accession>
    <name>A0A398D1H8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_02540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05034">
        <property type="protein sequence ID" value="RIE05034"/>
        <property type="gene ID" value="D3H35_02540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="97"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE05034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="306" mass="32802" checksum="313E6F2AF159649B" modified="2018-12-05" version="1">MAAEKSARFETAKRKPVSNEAADRKTPLRKLASNKELLFSGIAVAIIGIVALLPGLFATHDPYGLDVASRFQKPGPAHLFGTDNFGRDIFSRTVYGLQISVLVGLGVAILSGLLGLLIGLYAGFYRVLDQLFMRISDGLIAFPSILLALAIMSMLGPSIGNLMLCLTAVITPNVARVVRSGVLVIREQTYVEAMHALGASGTRILWRHIAPNTMSVLIVQTTFIFVEVIIVEAALSFLGAGIPSPTPSLGNLLLDGKMYIFNSWWMTVFPGAALFTVALVFNLLGDGLRDYLDPHADSAGGKSGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D230</accession>
    <name>A0A398D230_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_02000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05164">
        <property type="protein sequence ID" value="RIE05164"/>
        <property type="gene ID" value="D3H35_02000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="182" mass="17953" checksum="E17453D63808E7F4" modified="2018-12-05" version="1">MLCGTILAEDGLVGGVVMLSVTILAEDGSFGGVVMLSVTILAEDSSFGGVVMLCGTIPAEDGSFSGVVLLCGTIQAEDELTGGVVLLSVTILGKDGSFGGVVTLCGTIQAKDGLTGGVVMLSVTIPAEDGLGGGVVMLSVTILAEDDSFGGVVMLSVTIQAEDGLTGGVVLLYGTIPARHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D2D7</accession>
    <name>A0A398D2D7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_01555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05234">
        <property type="protein sequence ID" value="RIE05234"/>
        <property type="gene ID" value="D3H35_01555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017382961" evidence="2">
        <location>
            <begin position="27"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="445" mass="50062" checksum="9EFC704B00E6F0E9" modified="2018-12-05" version="1">MGGRFLACVLIMVTVSLSGCSVLSTHKDKDQVEGTLTVLYYNETLFAEDYGKRLKAEFPELEVKVVPTEDLMTQGSGYIPSILERIDKEKPDLFGLWSPLFDELANSNKLYDLDLLEGVGDVAQSFDSEFMAWIRGKAAGKLYGLPPAFQSMVLYYNKDIFDRYRVEYPRDRMSWEDVMQLANQIYSRSDPKSPVYGYAHYGDELYPLIETIGQTVSLNAVDARGKNVTIDSESWRKVFELVLNAYQTGGIYRPPERQDGNTASDSVSSHPFIQGKAAMAFGGSYLIPMLEQSWNSPSEQQLAKNWAVVTAPVDPRNPNRTFFASPSTLFAIRADTPNQSLAAAVLKYIVSENAIRSKSLTRDSMPIREDLLRDNDNRHLSSFYELTPADPPVRNAPDRFYATMSSLAEDAIQQVLQNKMSLDEALDRLQKNAQEQLDLANAQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBG1</accession>
    <name>A0A398CBG1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_25505</name>
        <name evidence="9" type="ORF">D3H35_28190</name>
        <name evidence="7" type="ORF">D3H35_29085</name>
        <name evidence="8" type="ORF">D3H35_29125</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000057">
        <property type="protein sequence ID" value="RIE00327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000057">
        <property type="protein sequence ID" value="RIE00333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000054">
        <property type="protein sequence ID" value="RIE00496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00327">
        <property type="protein sequence ID" value="RIE00327"/>
        <property type="gene ID" value="D3H35_29085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00333">
        <property type="protein sequence ID" value="RIE00333"/>
        <property type="gene ID" value="D3H35_29125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00496">
        <property type="protein sequence ID" value="RIE00496"/>
        <property type="gene ID" value="D3H35_28190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00927">
        <property type="protein sequence ID" value="RIE00927"/>
        <property type="gene ID" value="D3H35_25505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="73"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE00496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE00927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="280" mass="31497" checksum="6573CFEE4F557322" modified="2018-12-05" version="1">METLRRSVGRFLFPALLLVMLAIQIFPILWVLVSSFKTIDEFRVGSNPFALPKSLYLDNYVNAILKSDLLLYFRNSLIVVVFVLAGILVLSSMAGFALEKLRFRFRKAGLLFFLFGIMVPIQVTLIPLYQIFRDLHLLNTYTSVILPQIGFGLPVSIFLFVSFYKYLPNEVMESAVMDGASMYRLFVSIVLPMAANIVVTVATLYGVFAWNEFIFPFTFLNSKSLLTVTLGLRDYVGNYGMTDWGATFSAIMLTVTPTFIVYFFLSKSIISGMTAGAVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBN7</accession>
    <name>A0A398CBN7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00193">
        <property type="protein sequence ID" value="RIE00193"/>
        <property type="gene ID" value="D3H35_29590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="295" mass="31868" checksum="EEACCB386D92992F" modified="2018-12-05" version="1">MRFGAIEAGGTKIVCGIGNAEGKIEERISIATEEPRQTIQKVAEFFNNKNVEAIGVGSFGPINLDRGSPAYGSITTTPKPGWSNYPILAVLKQEFNVPFGWDTDVNAAAYGESMWGAAKGLDSCIYITIGTGIGMGIYMEGKSVHGLVHPEGGHILIRRHSEDEFAGACPYHQDCLEGLASGPAIEKRWGLKGIELPNSHPAWEMEAYYIGQAVANAVLMLSPKKVILGGGVMQQKHLFPMIQREVQSNLKGYVHSEHLLEKIDQYIVKPGLGDNAGLCGALALGIQAYESRQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCV7</accession>
    <name>A0A398CCV7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Thioredoxin reductase</fullName>
            <ecNumber evidence="7">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">trxB</name>
        <name evidence="10" type="ORF">D3H35_21430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="8">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01016">
        <property type="protein sequence ID" value="RIE01016"/>
        <property type="gene ID" value="D3H35_21430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="9">
        <location>
            <begin position="3"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE01016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="315" mass="33809" checksum="90038CA4C3C9D9E8" modified="2018-12-05" version="1">MYKSIVIGTGPAGLTAAIYLARANLSPLVIEGPEPGGQLTTTTEVENFPGFPEGIMGPDLMANMRKQAERFGAEFRTGWINSVDTAKRPFTLNLEGGETLEAETLIISTGASAKYLGIPGERENVGHGVSTCATCDGFFFRGKKIIVVGGGDSAMEEAHFLTRFASEVTLVHRRNELRASKIMQDRVRENPKITLGLNRTPVEVVAGDNVVSGLKVLNNETGEEEVIETQGLFVAIGHTPNTKFLGGQIETDEHGYIVTKPDSSETNVPGIFACGDVQDTKYRQAITAAGSGCMAALDCEKYLEGHATHDWSQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDB1</accession>
    <name>A0A398CDB1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_28755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00405">
        <property type="protein sequence ID" value="RIE00405"/>
        <property type="gene ID" value="D3H35_28755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="77"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="309" mass="34728" checksum="1336A196C991D8DB" modified="2018-12-05" version="1">MRLLIGRARKPFTKYAPLTVLMLPGLAYLLINNYLPMLGIFIAFKNINFTKGILGSDWAGFKNFEYLFKTSDAYLITRNTILYNAVFMIVGTILAIAFAILLNEITKKIASRFFQSVIVLPHLISFVVVGYLAYAAFSMDTGFMNKTILPMFGIDEISWYTEPKYWPYILTLVHLWKSIGFSCIIYLASIISIDSEYYEAATLDGASKWAQIRKITIPLITPVITMLTLLGIGRMFYSDFGLFFQVPMSSGAISDTTNVIDTYVYRGLMVTGDMGMASAAGVYQSIVGFILVLVANYVVRKINRENALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE32</accession>
    <name>A0A398CE32_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein insertase YidC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yidC</name>
        <name evidence="9" type="ORF">D3H35_24020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01436">
        <property type="protein sequence ID" value="RIE01436"/>
        <property type="gene ID" value="D3H35_24020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="265" mass="30346" checksum="E3FF5C2B7793678E" modified="2018-12-05" version="1">MVLSGCTPQGTATTTEDMLNSNSWWTKNVVYWFSLTLDKFAEWFGGSYGLAILLLTVIVRTIILPLMIKQYKNTKAMQALQPEMKKIRETHKDDPRKQQEEMMKLYQTHQVNPLAGCLPLIIQMPIFIALYNSIYKNSEIRDHTFLGFQLGLSPNEAGHWYYYIIPVVAALTTFIQSKMMSAQQTQQMGAMKGLLYIFPVLIFVMALSFPVALPLYWIFSNTYTIVQNYFMYVRRQPEPVKEPEQKPKGGKGKPQGKGKKGAHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE97</accession>
    <name>A0A398CE97_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-glucosidase/alpha-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_26600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00765">
        <property type="protein sequence ID" value="RIE00765"/>
        <property type="gene ID" value="D3H35_26600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019802">
        <property type="entry name" value="GlycHydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01324">
        <property type="entry name" value="GLYCOSYL_HYDROL_F4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="194"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="432" mass="48760" checksum="B23A6C32D54C451D" modified="2018-12-05" version="1">MSKITFLGAGSTVFAKNVLGDSMQVPSLQGFEIALFDINAERLRDSENMLNNIRTTSGSKCRIKAYTDRKEALRGAKYVVNAIQVGGYDPCTITDFEIPKKYGLRQTIADTLGIGGIFRNLRTIPVMLDFASDIREVCPDAWFLNYTNPMAVLTNVMNAYGGVKTVGLCHSVQVCMPHLFEHLGMDKEGVQTKIAGINHMAWLLEAKKDGVDLYPEIRRRAAEKQKEKHHDMVRFELLHRFGYYVTESSEHNAEYHPYFIKRSYPELIERFNIPLDEYPRRCVNQIADWTKMRDSLVGNANLTHERSHEYASYIFDAMETNVPFKIGGNVMNNGLITNLPREACVEVPCMVDSFGVTPTYVGDLPPQLAALNRTNINTQLLTIEAAMTGKKDHIYHAALLDPHTSAELSIDDIVSLCDDLIEAHGDWLPEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEE0</accession>
    <name>A0A398CEE0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_21860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01073">
        <property type="protein sequence ID" value="RIE01073"/>
        <property type="gene ID" value="D3H35_21860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="276" mass="30494" checksum="A209DBE973B63DFF" modified="2018-12-05" version="1">MNIAISQITTLPASTAADLEAFSQTGWQAVELAISKVDRYLAEHSVEQLGADLTAAGLVPIAAIGLASSEAGLLLSTKDNYESYERGLERQLAICKALGIKNLGIGADPASKEYEGWYETALANLRKAGDLAERYEVRLGLEFMSLAPPIGPFILENMDQTLRIVEDIDHPSIGYNLDLFHFYRSGGSLEDIEALPVEKLFHVHLCDLPHLKLAELDDSHRLLPGEGILPMDKIVQVLRDKGYTGYLALELLNQELWDKGPIYTADRGMHAMQKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEE3</accession>
    <name>A0A398CEE3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00815">
        <property type="protein sequence ID" value="RIE00815"/>
        <property type="gene ID" value="D3H35_26895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="134" mass="15660" checksum="CACE9C4527B7A8FA" modified="2018-12-05" version="1">MPRLFMKRLKELRNRKKMSQEELAGALNIPRTTIAGYESGIRSLPRERRLKHIASYFGVSIDYLIGFTDEENEPEDLQNQIVKLIRSANVHYDYKYTYSDKEKEQIIEILLNIASMDQAERKHALDLIGKMAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEF5</accession>
    <name>A0A398CEF5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Recombinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_24715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01556">
        <property type="protein sequence ID" value="RIE01556"/>
        <property type="gene ID" value="D3H35_24715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="1">
        <location>
            <begin position="7"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="2">
        <location>
            <begin position="165"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="284" mass="32204" checksum="EF42B3EB2277A9B4" modified="2018-12-05" version="1">MKQKIKSVLGYVRISSDTQKDNTSIAEQKKRIQAYCTSQNWNLKGIFVDEAKSGSKIDERIEYVKMIEFAQDKSNEIDAIIVFKSDRIHRHLKNLLIMIEDDLQPHDIAFISVSENFDTSTPQGMLTLQMLGSFAEFERNLINERTRSGRVVTAKSGKYAGGKIPFGYLIDDGKFVVNECEATLVRKMFQLYAEGKSYGFIAKYISSLIKQSGDDPGSSDANKSWSRTSICYILRNASYTGLLSYDGKKEKNQIQVKASIPAIISKQLFNKVQAMREQKRKMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CES9</accession>
    <name>A0A398CES9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01223">
        <property type="protein sequence ID" value="RIE01223"/>
        <property type="gene ID" value="D3H35_22785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="120"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="267" mass="30517" checksum="FD8E12BC3541027F" modified="2018-12-05" version="1">MTQEEVLEGGNVNHIVRRANTVLRPTGYWSPCVHELLKHLEQQGFEGAPRFLGIDDSDREILTFISGEVPGNDYPELEPYMWSDETLVGLARLLRRFHDATEGFTLMTEGRWQLSYADDGEHEVICHNDAALYNVVFQKGAPVALIDFDMAGPGPRMWDIAYALYTSVPLTSFAPEYSSGTIVEYQSDLHAAERCRRIHLYFESYGTPIPNELRQWIIQRLTTLCNTLRNGAADGNPAFQKMVDEGHLAHYESEIRFVTDHFEDWMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFD3</accession>
    <name>A0A398CFD3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01125">
        <property type="protein sequence ID" value="RIE01125"/>
        <property type="gene ID" value="D3H35_22170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="111" mass="13102" checksum="BECC561B5A537779" modified="2018-12-05" version="1">MNVATLSALAEPNRLHIVELLRFGPRPVGEIADELQLNQPQVSKHLRVLSEAGIVEVRPIANRRIYKLRPQPLRELDTWLESFRRLWEEKFDRLDDYLRELQAQDSMDENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFK8</accession>
    <name>A0A398CFK8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01976">
        <property type="protein sequence ID" value="RIE01976"/>
        <property type="gene ID" value="D3H35_14495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014202">
        <property type="entry name" value="Spore_II_R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09551">
        <property type="entry name" value="Spore_II_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="173" mass="19036" checksum="6B8ECFFC1C6D7EA0" modified="2018-12-05" version="1">MRRQGQFISSFFIKITALIPSSRLIPAAFVLLIGFAALLGKVTTANAGTVIPSDAIRIRIIANSDSDFDQSVKRHVQAEVSSLIESWGPMPNTHDEARELIRSRLEQVRDVAEQALEAIDVTYSAQVTLADVPFPEKIFDGRNYAAGNYEALRITLGEGGGANWWCVLFPRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG86</accession>
    <name>A0A398CG86_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_25720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00962">
        <property type="protein sequence ID" value="RIE00962"/>
        <property type="gene ID" value="D3H35_25720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="64"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="137"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="423" mass="44808" checksum="8EE472069CE2C604" modified="2018-12-05" version="1">MRNLSLGRKFAYGFLGLVVLLVLAFLLIVIQLDVSDNMALFIELIAIFVVVIAAAGFGLFIMERNITGSIGGVTSTLKNIASSGGDLTRRVHVTSYDEVGDLAVSANGMLDGLQKMMKELRDSTAELAAAAIQFKQGADENARVSGEVSKAVERVASGSETQVAQTQEISAVMQETLDGLNQVASTTTGVSDMAQTTRSRASEGSELLRTTSADIIQVEKAFRSLQGTVRGLNHKSEQVREVIGYISEVSNQTNLLALNAAIEAARAGEHGRGFAVVAGEIRKLADQTQQSAVQIADTLEAMSGDIAQVATMFEQSAGQVFAAVAGMKNAEETFREIVDNVSQLSGNIVDVAASVEQMSAGSASVVQSIQDISRITEETASFTEQVSAMTEEQLSSTEEMARTADNLSSMAARLKGLVGNYKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGJ2</accession>
    <name>A0A398CGJ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02336">
        <property type="protein sequence ID" value="RIE02336"/>
        <property type="gene ID" value="D3H35_16595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="265" mass="30050" checksum="91302A8DC3FFBF88" modified="2018-12-05" version="1">MSRVSFTMSLFREYIANYLKTKLTYRADFWVEVLSDLLFSAMNLIFIFIVFQHTPSLGDWSEAEVVFVYGYYMIPFGIFGTFFNLWNFGDRYIVKGEMDRILTRPAHSLAQIMLENVDPPSLIGSLVGLAIMAMSWNTLGLPFDWYDPLILIVMIAGSMLIYAGLYTTLAALSFYSDAPTGIIPLMFNIQNYGRYPVQIYNKAIRFLLTWVLPFAFVGVYPASFFLDRHGDLWLSLITPAVGIVAAAIGLAVWNRGVHRYRGAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGR0</accession>
    <name>A0A398CGR0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglutaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01142">
        <property type="protein sequence ID" value="RIE01142"/>
        <property type="gene ID" value="D3H35_22300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="93"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="263" mass="30187" checksum="871CEAC07B767E45" modified="2018-12-05" version="1">MSTAYAQLTRTTDPGELVDLYEGLPEDLPSLCRLIKAQLIHPDNTDRFKHSLKSAKREDARFDTVADMLEALEERNANGLLMDRAPNERLILSCRYHALLLLSILRSRNVPARCRVGFASYLSDRAAKHVDHWICEVWNDREERWVLVDPDREIVDIREGFILAGDAWLMARNNEINPRLFGAKTSWGLSYIRNNLCHDMSAILGREPRYWDFPPIGKQAIDGSNEEALQLLDELAIYLQDPDANIASVRRLHAENACLQYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGU2</accession>
    <name>A0A398CGU2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_22970</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01675">
        <property type="protein sequence ID" value="RIE01675"/>
        <property type="gene ID" value="D3H35_22970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="17"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="333"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="366"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE01675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="577" mass="64753" checksum="053C2A2C4D904732" modified="2018-12-05" version="1">MLRRFMINYRPYRRLFLIDFTCAVVAALLELGFPIGVQWTIDELLPSRDWSLIAWVCAGLLALYVISMGLQFVVNYWGHMLGINIETNMRKNLFNHLQKLSFRFYDNTKTGQIMSRLTNDLFDLGEMAHHGPEDFFIAIMTLVGAFGIMAMVNWELACITFIVVPILAWLIVFFNKKLNIAAVGMFEKIADVNARVEDSISGIRVVKSFGNETFEKERFEKNNQAFRSAKLKSYFAISLSSSGIYMLTRFITLTVLVFGAWFAYTGRISYGELVGFLLYVNIFLRPIDKINALLELYPKGMAGFKRYCELMDTEPDVKDAPDAVDVQRLRGDIEFRDVTFGYENHAHILQGINLRIRAGETIALVGPSGAGKSTLCSLIPRFYEIDGGELTIDGIDIRRMKQTSLRNQIGVVQQDVFLFNGTIRENIAYGRLGASEEEIAEAASQASLDGLLESLPDGLDTFIGERGLKLSGGQRQRLSIARIFLKNPPILILDEATSALDTETESLIQQALERLSRNRTTLIIAHRLATIRHADRILVVTEDGIAEQGRHEELLAAGGVYARLSAAQVGQAAAKEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH18</accession>
    <name>A0A398CH18_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02043">
        <property type="protein sequence ID" value="RIE02043"/>
        <property type="gene ID" value="D3H35_14865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="66" mass="7547" checksum="B084800380E217D0" modified="2018-12-05" version="1">MRNYSSHPLRYSYQDAAEFVATSSGAGQAGKSPHLPYSRNYAHTRTRISKIVIPFMLAEYSQHPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHG2</accession>
    <name>A0A398CHG2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01422">
        <property type="protein sequence ID" value="RIE01422"/>
        <property type="gene ID" value="D3H35_23935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="177" mass="20429" checksum="3AC55648BAD98E87" modified="2018-12-05" version="1">MSPSSPSVVSEPTIYHYRLIRKITLRPESKYSYMATALLGTAALTVVYGQFGLAVAAASSVIMLVVHAIVLRLTLRRVDEPSEKKWTFRSDWPWIGPLPILDSNLGLFRRLHFHLILVGCCVTGLFYPWASSAWVIALLYWHFWLLSPRVRLLWSLRREKGDGVIRLDGHEIYYYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHQ0</accession>
    <name>A0A398CHQ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00649">
        <property type="protein sequence ID" value="RIE00649"/>
        <property type="gene ID" value="D3H35_27170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="249" mass="25881" checksum="2B328B274F5DB528" modified="2018-12-05" version="1">MFSDIPMKGDDDAMPHYLNTLRIAGCAVLLGLMLASCSQKPESRTTPPSEDTTVPSSAQAATDEPVSSPSTITLIEDEPSESPASSPTGETIAEPSPSSAGVGAANASPDLKKPAEEEGRSFSSSDPELAAIRLSETEASVTKKLGLPAESFTLPGDKTSTEMWEYDGITVGFGHDHRIVYVEVTSSEIATGIQGLQLGTTAKKAAHALGLDVPQRSNVLTAEIAGGSLKLDLDPDSRTVISIKLIADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHW2</accession>
    <name>A0A398CHW2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glutamine ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_24985</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01602">
        <property type="protein sequence ID" value="RIE01602"/>
        <property type="gene ID" value="D3H35_24985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017341023" evidence="7">
        <location>
            <begin position="25"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="8">
        <location>
            <begin position="54"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="9">
        <location>
            <begin position="54"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE01602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="278" mass="30050" checksum="C452FA032730541B" modified="2018-12-05" version="1">MTKKSMLVAALALSVFAVVTLAGCSSNSDGNSNNAAASGSSPSPTVSSPVAGKQYIIATDATYAPFEFKQGDKYVGIDIDLLDAIAKLEGFTYELRPMDFKGIIPAITSNQIDASIAGITITEERRKTIDFSEGYFESGTSAVVHKDNTSIESAEDFKGKTFAVKKGTVGAKYAEEHKEEFGATIQYFDDTPTAFQQVENGNADIGFEDYPVIAYMLSVNKDSKLRIAVPKLAVEYYGFAVNKGKNQELLAAFNDGLKKLQQNGEYDKIVAKYLGENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI42</accession>
    <name>A0A398CI42_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">M23 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_14715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02015">
        <property type="protein sequence ID" value="RIE02015"/>
        <property type="gene ID" value="D3H35_14715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="138"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="242" mass="25927" checksum="4265BDA33580FA90" modified="2018-12-05" version="1">MINDNNKPTRKLEDSQKSVTGSHSAAKPSGWKKLLSKRWVFPAAYMAAAAIIVTILWMNSDTDKADKTSPAVSSVSSEQTDGASSPDAAPAVANGEALQWPVAKMDDMKTLIPFYDAAASEEERVAAMVEYPNNTFAPHMAIDLARKDAQSFDVQAALGGEVTVAEQTAKNGYEVHIKHANGLETVYQSLTDLKVKSGDKVEQGDVIAKAAQSESEPGEGIHVHFEVRNNGQSVNPTSLIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI45</accession>
    <name>A0A398CI45_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02936">
        <property type="protein sequence ID" value="RIE02936"/>
        <property type="gene ID" value="D3H35_20225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="289" mass="32195" checksum="4825FDF225171921" modified="2018-12-05" version="1">MSQSADRLEYPTRERIAIVTGTSSGFGMLTAVELARKNYRVIATMRNPERAIELRERAERAGVTERIEIHGLDVTDSLSIERVVADTLRVHGRIDVLVNNAGFAVGGFVEEVSMESWRRQMETNFFGLVAVTQSVIPAMRQQRSGLIINIGSISGRMGFPGYAPYAASKFAVEGFSESLRHELAPFGISVVLVEPGAYRTPIWDKGLEQISGSDNSPYIHRLRAILRYSRRAAETAPDPQQVADLIGRLAGARSPRLRYPIGRGSLLALWGKALLPWKWFERLIERGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIM4</accession>
    <name>A0A398CIM4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class II fructose-1,6-bisphosphate aldolase</fullName>
            <ecNumber evidence="4">4.1.2.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fba</name>
        <name evidence="4" type="ORF">D3H35_21660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01049">
        <property type="protein sequence ID" value="RIE01049"/>
        <property type="gene ID" value="D3H35_21660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011289">
        <property type="entry name" value="Fruc_bis_ald_class-2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01859">
        <property type="entry name" value="fruc_bis_ald"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="209"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="230"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="284" mass="30441" checksum="1D8C9FB80139B00E" modified="2018-12-05" version="1">MPLVSMNEFLPKAKANKFAVGQFNMNNLEFAQAITEAAIEEKSPFIFGVSEGALKYMGIEYTVAIAKAAAEKSGLPIALHLDHGSTFDVAMKCIRAGFSSVMFDGSHHSFEDNIRLTKEVVKAARAMGVSVEGELGTIGGVEDDLSVDEADASLAKPEEAIRFYEETGVDCLAIAVGTAHGMYKGEVKIHYDIIKAVVSQIPVPVVLHGGSGVPDEMIREAIQAGVGKINVNTENQVACTAAIREVLNKDANVIDPRKYLTPARNAMKAVVQEKIRLFGSSNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIR8</accession>
    <name>A0A398CIR8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">ychF</name>
        <name evidence="7" type="ORF">D3H35_14470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01972">
        <property type="protein sequence ID" value="RIE01972"/>
        <property type="gene ID" value="D3H35_14470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="3"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="6">
        <location>
            <begin position="281"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="366" mass="40197" checksum="0E8B8B21C30214C4" modified="2018-12-05" version="1">MALSCGIVGLPNVGKSTLFNAITQAGAESANYPFCTIDPNVGVVEVPDERLQKLADIVTPNRIVPTAFEFVDIAGLVKGASRGEGLGNKFLANIREVDAIVHVVRCFHDENITHVSGKVDPINDIEVINLELILADIDSVEKRMERSRKNMRGGDKKYAQEVEVLERVHAALLEEKPARSVELTEEEKLLVRDLHLLTIKPVLYAANVSESEAANSDGNEYVQRVREFAAAEGSEVVPISARVESEIAELEGEDKEMFLEELGLTESGLDRLIRAAYKLLGLYTYFTAGVQEVRAWTIRKGTKAPQAAAVIHTDFERGFIRAEVVGYADLVGSGSMNAAKEKGLLRLEGKEYVVADGDVMHFRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIT7</accession>
    <name>A0A398CIT7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit c</fullName>
            <shortName evidence="13">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpE</name>
        <name evidence="15" type="ORF">D3H35_14585</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01992">
        <property type="protein sequence ID" value="RIE01992"/>
        <property type="gene ID" value="D3H35_14585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="PTHR10031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="14">
        <location>
            <begin position="7"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="13">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE01992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="73" mass="7535" checksum="FA28EE670401E30C" modified="2018-12-05" version="1">MELYALLAAAIVFGLGALGAGIGNGLIFSKTVEGISRQPELRGTLQTTAFIGVGLVEALPIISLVLAFIFMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIW5</accession>
    <name>A0A398CIW5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02325">
        <property type="protein sequence ID" value="RIE02325"/>
        <property type="gene ID" value="D3H35_16535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="334" mass="37390" checksum="094B1D442A48E79D" modified="2018-12-05" version="1">MRILIIGGTGFIGPYVVKELHEEGHTLAMFNRGHAPLELSDVTVIQGDIESLADYKSEFQRFAPDVVVHMIAYTERDAHTAVSLFAGIAKRIVVLSSMDVYRAYGIVIGLEDAPPLPIPLDEQSPLRERLYPYGGDYEKILVERVMLNQAALLPATVLRLPMVYGPGDPSHRLYKYVKRKLDNRSVLVLDEGFAHWRASRGYVENVAHAIAVAAVSPVTGNRVYNVGEEDAHTEKEWAHAIARTLMWEVEVYTAAKSELPSELANRLLRTEQDWITNTSLIRKELGYKEIVAPEAALLATVQWEAANPPAALHPKDYPLLNYEDEDSFLSNCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ30</accession>
    <name>A0A398CJ30_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toprim domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02753">
        <property type="protein sequence ID" value="RIE02753"/>
        <property type="gene ID" value="D3H35_19105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toprim" evidence="1">
        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="120" mass="13705" checksum="3832EDA9D32E32B0" modified="2018-12-05" version="1">MDVAIIVEGKNDKSRLSRVLSPAVPVHCTFGTLNTDKIEKLRKEIGHRQVYLFTDPDSSGRRIRGVLRDVFPDAEHIYTRRGYAGVEGTPEEYLIQQLEKAGLEEYILYPEPTGDQWTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ56</accession>
    <name>A0A398CJ56_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_26150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000047">
        <property type="protein sequence ID" value="RIE00858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00858">
        <property type="protein sequence ID" value="RIE00858"/>
        <property type="gene ID" value="D3H35_26150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="84" mass="9176" checksum="45C2CCD87F5F7E54" modified="2018-12-05" version="1">MTASLIIVQFISVWNDLQLPLVLLNSADHPTVSISLYKFFAGRSMSDLSLLFGGIMLTLLPIIVLFVSFQRFFVKGLSAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJA4</accession>
    <name>A0A398CJA4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CPBP family intramembrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02400">
        <property type="protein sequence ID" value="RIE02400"/>
        <property type="gene ID" value="D3H35_16970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="197" mass="22390" checksum="8054DE78ADFCC1F3" modified="2018-12-05" version="1">MSMNRAAIFSSIFLIVFSMLIIYFWKGIHTGNYLLQLFSLKFLFKDMMIGLIGSIPLLLLLVFLIVVGKANLPETKGSVDLVCFLRQKRMNLLTVSIVTVLGEELLFRGVLLIWINSIFPSLLSNITISLLFTALHYKDQYKGQPYLLLYLFVMSLLTGIVTLEQQTLWSAFTIHAVSNFVTSALIRTKVIRLQSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJG2</accession>
    <name>A0A398CJG2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02833">
        <property type="protein sequence ID" value="RIE02833"/>
        <property type="gene ID" value="D3H35_19580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="105" mass="11095" checksum="37CE92F36E88A557" modified="2018-12-05" version="1">MSQANIPNITPDITVTRDDAINLLLSSIALEELGLSHIINAEGEKIQYALGTLPGISSPPATISELLAVNESVRHTLRDITKKEFVLQGKLDSVLSIPSSSGSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJH3</accession>
    <name>A0A398CJH3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02470">
        <property type="protein sequence ID" value="RIE02470"/>
        <property type="gene ID" value="D3H35_17375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="95" mass="10983" checksum="CDB0FA5C9CAF080C" modified="2018-12-05" version="1">MSFDELLKDLQGQRTIQEDPNHVPLEKLFNESFMSKHSGFKSFEEFLEKGNFQVRTQEDVKNIPDELFDRHVARETGFANWEAMLAAATAEYAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJL7</accession>
    <name>A0A398CJL7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="7">GSA</shortName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="7">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hemL</name>
        <name evidence="9" type="ORF">D3H35_16575</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02332">
        <property type="protein sequence ID" value="RIE02332"/>
        <property type="gene ID" value="D3H35_16575"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="435" mass="46621" checksum="722E11681AFD12CE" modified="2018-12-05" version="1">MQRIKSEQLYGEALKHIVGGVNSPSRSFKAVGGGAPVFMSRAEGAYFWDADGNRYIDYLAAFGPIITGHAHPIVTSAIVQAAQNGTLYGTPTEHEIELAAELKRAIPSMDKVRFVNSGTEAVMTTIRVARAATGRSKIIKFAGCYHGHSDLVLVAAGSGPSTLGIPDSAGVPASIAGEVITVPYNDLDGLKLALERWGDEVAAVMVEPIVGNFGMVMPHEGFLEELCRMTREAGALVIYDEVISAFRFHYGSTQTFQAFPDREAIRPDLTALGKIIGGGLPIGAYGGRAEVMDRVAPLGPAYQAGTMAGNPASVMAGLACLEVLRGDGVYPRMEALATRLADGLRQSAERHGIPLTVNRIVGAFSTHFCNHPVTNYDEAQDTDGEAFARFFRLMLDRGIYLAPSKYEAWFLTTAHTDEDIDATLEAAEASFQEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJX3</accession>
    <name>A0A398CJX3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02442">
        <property type="protein sequence ID" value="RIE02442"/>
        <property type="gene ID" value="D3H35_17205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="315" mass="34956" checksum="453AAF719AC83733" modified="2018-12-05" version="1">MSKARGASTLPARSVVRWGDATYRIEAPTWFAWQDAMERSTRTDGNVDAQRLLEEALAVTARDENDQRLSIDSIRLLSALDGDRLLAGTLELIERQRQYYAFREQEQPDGSIALLGNQVYLKLQSWTFGERNDVLRRSLRLENGQAAVDMALYERMMILACVRTGEDTRLQPSELSGWTVPFGEKVLELLDQLNGIESRYDELLQACLDSGQHHPDLDLIQLCRTFGWYPDRVLGLDAQLAERLSAGVRILKKSGLLADGPAASRLPSAMPAEAAAAASYNPQGGYDAARSNPLGDTGIWELEDGEVTTILVNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK90</accession>
    <name>A0A398CK90_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_29245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000059">
        <property type="protein sequence ID" value="RIE00307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00307">
        <property type="protein sequence ID" value="RIE00307"/>
        <property type="gene ID" value="D3H35_29245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="2"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="114" mass="12949" checksum="48F07329D0C2F7E3" modified="2018-12-05" version="1">MLGLYKVECDSIFYDGIPINQFDENSLYNNTSAVFQDFIKYQTNVRDNIAVGDITYVNNDEKLESALNRVLFDNHFPGGLNTKLGYIDQDSTNLSGGQWQRLALSRVFVKDNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKF0</accession>
    <name>A0A398CKF0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="7">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">tilS</name>
        <name evidence="9" type="ORF">D3H35_23495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01679">
        <property type="protein sequence ID" value="RIE01679"/>
        <property type="gene ID" value="D3H35_23495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012796">
        <property type="entry name" value="Lysidine-tRNA-synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015262">
        <property type="entry name" value="tRNA_Ile_lys_synt_subst-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09179">
        <property type="entry name" value="TilS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11734">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00977">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02433">
        <property type="entry name" value="lysidine_TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TilS_C" evidence="8">
        <location>
            <begin position="381"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="21"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="474" mass="53583" checksum="411F6E1827A08F44" modified="2018-12-05" version="1">MEDALKDGWRQKGETLVAAVSGGPDSMALLHMLCRWRDEEPFPLVAAHVNHMFRGAESAAEAVLVRSTAERWGAVAETADIDLPAYIAETGMNPQEAARERRYAFLTETARRHGASKLILGHHADDQAETVVMRLLRGTGVGGLAGIPYRRFEQNVELIRPLLRITKRELLAYCERNGVPYAVDSSNLDRHYFRNSVRLDILPVLESYNPGLKESLVRLSKLAAEDNDYMEAEAAKVFAEIVSPAGNGFRWERRRFRSLHVALQRRLIKLILNCSKGSRYSLEFHQVERVLDAVAEDRRSVARIELGEDRVFVREYDELYAGPEREQARSFHYPLPDRDGELAIAETGHRLRVRRIQGAVSSPPGHRWEAFFDEDELRLPLIIRSRHPGDRMQPYGLNGTKKVQDMFVDAKVPRSERDRYLLLADGDGRVLWIAGLRRSGHAPVGAQTRSTLVVTVDDSPESMNIPHPNADMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKH6</accession>
    <name>A0A398CKH6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02800">
        <property type="protein sequence ID" value="RIE02800"/>
        <property type="gene ID" value="D3H35_19385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017196015" evidence="1">
        <location>
            <begin position="26"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="383" mass="41351" checksum="3F5F0887FB13AF0A" modified="2018-12-05" version="1">MNRKMKSLAVLSALTAVVALGSGCAARGQDAGREVVQEVGNDITVLDNPESLSYEQTPASAIVRIDDVRGTDWLSDEAIIVSRENKDVSPVPAEGTTWYPSKLYVRTLDSGKETPLIGGGSNDNQGYALLSPNRAYLFYKTFDLQSNTGKGYILDMATSQSRSFTGADAMELQNGLWVDNDSLLYSELTGAVNEVSVDHDGALDSKLLLQTRSPFLNNLAYIGNRLYFSNGSGLLLVHDFRSENTAVALLKNVVWMTPSPDGSQLAVVRRVKSGAMELVVTDVKGNVLQTLAQDFQIYGVAWSPDGSRIAYSGLTENGTARGVYLADVAAGSSSELQVDVKFISDPLRFSPSGDRLLISTTVPDENRGVNRFVTYLVAVKQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKJ5</accession>
    <name>A0A398CKJ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3427 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_29630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00201">
        <property type="protein sequence ID" value="RIE00201"/>
        <property type="gene ID" value="D3H35_29630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021835">
        <property type="entry name" value="DUF3427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11907">
        <property type="entry name" value="DUF3427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="220"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="338"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="552"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1050" mass="121174" checksum="EB4E2E47973B1C27" modified="2018-12-05" version="1">MKQGLYEQVINQITAQRLSGLDAAVFNVGKEKLDVEEARKLLSNYIGLVTRRALKMVREQTSNDEELILAQVQTCNEMIATLKSSLGPEECEQLKLDEQGEILTYIYSKINHIRSFKDEKIVRPATPLSQSSLFTGSHSEPNMLYELKHEIVTADRIDFLVSFIKWSGLRCLMEQLEQFTSNGGQLRVITTTYMEATDYKAVMELSKLTNTEIKISYDTDRTRLHAKAYVFKRDTGFTTAYVGSSNLSNPALTSGLEWNLKVTEKDSYDVLKKIEATFESYWNDREFKSFISSDVEHGHQLQQALRKNKPPGQASLYFPFEITPYDFQKEILEKLEAQRTLYGRTNNLVVAATGVGKTVVSAFDYKRFAKQRSHARLLFVAHREEILKQSRDTFRYILKDLNFGELHVGSNQAQSLDHLFISIQSFNSMRLAENTTPEFYDYIIVDEFHHAAAPSYQKLLAYYRPRILLGLTATPERMDGKDVLGYFDDTIAAEIRLTDAIDRKLLSPFQYFGVTDQVDLSQVKWSRRGYDLAELENLYTNNKIRAMQIFNSMKKYVTELEQVKGLGFCVGVDHALYMAKIFEEAGMPAIALHGKSSDEDRNQAKSRLVSGDIRMIFVVDLYNEGIDIPEVNTILFLRPTESLTVFLQQLGRGLRLAEGKECLTVLDFIGQAHQDYNFQDKFRALIGKTKHSVQHYVEHGFSNLPRGSFIQLEKQAKVYILRNLKQSTTTRRSLINKIKYFEGDSGLKLTLESFLHYHGLSLYDLYGGRTGNRTFNGLKVEAGLMDAYEWENGEYLTKRIPALLSLNSRRLLRFVLAYLQEGAQPQTEEERLMLNLFYFTFYRSEPRKQGFENVEQAIEAIMSCSVFREEIVDILKINLSHIGFVDKRNEFTYACPLDIHCSYSMDQVLAAFGYWNEEKAPSFREGVKYFEDKQTDIFFITLNKSDKDFSPSTLYEDYAINERLFHWQTQSRTSEESKTAQRYIHHKQQGTRIALFVREYKEEHNYTSPFVFLGEAEYVRHEGSKPMSMIWRLKEEMPPALIPAANKVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKL3</accession>
    <name>A0A398CKL3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00221">
        <property type="protein sequence ID" value="RIE00221"/>
        <property type="gene ID" value="D3H35_29750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="220" mass="24595" checksum="A6C6022A7A616FBA" modified="2018-12-05" version="1">MAAAKRLGLSLGIDEVVCGEDRSSTCRGSAFCLPLPCGRPLPPEITKAVFERLEETSNEDTAKQEWNKASEAANVLLLKSDGIKVMVETIQKADKYIDILMFELSHPEIVIALIEAADRGVAVRVIVSNHKSYSNNKNYESLTQAGIPIRMKSNLHSKQIILDEKYVLTGSLNASVVKHDNKESLEVFREEARVGAYIAQFQKLWLDPQTRDFKAYRKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL06</accession>
    <name>A0A398CL06_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="9">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="9">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">fabH</name>
        <name evidence="12" type="ORF">D3H35_19815</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="9"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02872">
        <property type="protein sequence ID" value="RIE02872"/>
        <property type="gene ID" value="D3H35_19815"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="11">
        <location>
            <begin position="110"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="10">
        <location>
            <begin position="239"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="9">
        <location>
            <begin position="256"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE02872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="332" mass="35142" checksum="B5348AE6AA1FDBD6" modified="2018-12-05" version="1">MPLQSNSTITAIGSFVPSAVITNEDLERMVDTNDEWIVRRTGIQKRHRAADDEFTSHLAIAAVRDLIDRYRIDIQGVDGIIVATTTPDMPFPSVASRIQHAFGMNAGLAIDLNAACAGFVAALQLANGLLLSGANRKVLVIGAETLTKITDYSDRSTCILLGDGAGAVLVEAGSALENGAFLASYARTDGSGGKHVYCSGLSDRLDGEALAGEGHMVQNGREVYKWAVTQVPQGVQSLLDQAGVSLQQLDWLVPHSANLRMIEAICERLSLPSERALESVIRNGNTSAASIPLALDAAVRDGRLQPGHLLALYGFGAGLTQAGLLLRWTIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLC5</accession>
    <name>A0A398CLC5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AtpZ/AtpI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01989">
        <property type="protein sequence ID" value="RIE01989"/>
        <property type="gene ID" value="D3H35_14570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032820">
        <property type="entry name" value="ATPase_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09527">
        <property type="entry name" value="ATPase_gene1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="82" mass="8581" checksum="62002E32636A4B62" modified="2018-12-05" version="1">MTESPRKPNLPPDDNPWKAAGLVTAIGAELAVCVGLGWWLGSVYDDRNGTEYGYMTGLVIGLVAGIGSAVALIRKYTGVGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLE0</accession>
    <name>A0A398CLE0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00667">
        <property type="protein sequence ID" value="RIE00667"/>
        <property type="gene ID" value="D3H35_27280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="171" mass="19470" checksum="BFFB4D1028110732" modified="2018-12-05" version="1">MVHMVHLKGGVIILTLLRSQDADDEFLFEIYASSRLDEFANLGWPEQELNRFLRMQYEMQKISYQARYPDACYEIVADQGRRVGRMLTANTEEAVVLVDVALLPLARGQGIGSLLIRELQRKAASANKPIRLNVLADNPARRLYARLGFRETGHQFPYIAMEWNSNGVDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLY9</accession>
    <name>A0A398CLY9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_11300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03270">
        <property type="protein sequence ID" value="RIE03270"/>
        <property type="gene ID" value="D3H35_11300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032508">
        <property type="term" value="P:DNA duplex unwinding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00368">
        <property type="entry name" value="TIGR00368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="218"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="519" mass="56514" checksum="52D9B8825849C5FC" modified="2018-12-05" version="1">MYVKMLSASVAGVEGRIIEVEVDISSGLPQVSVVGLPDPAVRESVERVRAAIQNGGMKFPLDRITVNLAPADLRKEGSAFDLAIAAGILCASGQLSPDKLEGAMLIGELALNGDVRAVPGILPMTEQARKRGLKRVVVPYPSMAEAALLEGIEVVGIGSIKEWGSLGEFVDFSVGAKLRVHNRERAVAETDDSDHQLDLADVIGQQQGKRALIIAAAGMHNILFVGPPGTGKTMLCRRLPSLLPDLDDEEALTLTKIYSVSGKLVGSRQSLIRARPFRMPHHTVSASGLIGGGSIPKPGEVTLAHHGVLFLDEMPEFSRACLEALRQPLEDREVTIGRARGVCRFPARFMLAASMNPCMCGYYGGSIEEKPCTCPPSAIARYRSRMSGPLADRIDLQVELPRVTFRESKSDEWTSARVRTKVAEAYERQKLRYTGSGVSWNSELQGRLLKRYARLSSEAESLIGRAYKLLGLSFRAHDRILKMALTIADLDGRDRIETEDIAEAIQYRCLDHSYAKSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM14</accession>
    <name>A0A398CM14_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_10310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03683">
        <property type="protein sequence ID" value="RIE03683"/>
        <property type="gene ID" value="D3H35_10310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="61"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="174" mass="19345" checksum="597522392534CF56" modified="2018-12-05" version="1">MSRIYRMLLEVERPFFLHVNLRYRHYLLNRLFHIFSLLGGATFTLVFSLAVGWFAAEPWSTAGWQALAAVALSHIPVAVAKRSAPRLRPYQEFPQANTNRKPLKDPSFPSGHTTAAFAMLTPWMLAEPMLIPILLPVGIGVALSRVYFGLHYPSDTIAGALLGSATALLVSIWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM16</accession>
    <name>A0A398CM16_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03485">
        <property type="protein sequence ID" value="RIE03485"/>
        <property type="gene ID" value="D3H35_12620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="215" mass="24873" checksum="F3474C1E3577E723" modified="2018-12-05" version="1">MRDQLDVPVSTAPLASDTVLFEDAGNAATLYYLPRYKLDTESTVDGKERYKAVLEARAPGWVLRLHLVKYAAEELGLADRQAQPLPHRTTLTLRYTLARVGRRSEGACFRRSYGRGERPASRYPAQRHGRARRAVCGHDQTRIQSEFYCPALHASRRPHPWLFERFPHKLPDQRIFIPRRRFPLERFRDRSANLKINLPQASRKPGFDPLSATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM89</accession>
    <name>A0A398CM89_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04466">
        <property type="protein sequence ID" value="RIE04466"/>
        <property type="gene ID" value="D3H35_07750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="244" mass="25603" checksum="B81CC93DD7B86B19" modified="2018-12-05" version="1">MELHGKKVLVCGGASGIGAAAVQAYRAAGASVAVFDISFKEERLTETIIEIPVDLSDSGQVDEAFAKLESRWDTLDILVNNAGIECVAELEDTSEAAWDRVMGVNLKSVFLCSKAALPKLKASRGAIVNTASQLAFVGASSFTAYTAAKAAVVNFTRSLALEVAADGVRVNCICPGAVDTPLLRRQFEGRRGPQGTLDDLVGMHPIGRLGKPEEIANCILFLSSPLASFVTGSAMIADGGYTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMC4</accession>
    <name>A0A398CMC4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_12145</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03412">
        <property type="protein sequence ID" value="RIE03412"/>
        <property type="gene ID" value="D3H35_12145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="304" mass="32527" checksum="E6EDF2E61EFAC07D" modified="2018-12-05" version="1">MKIFLQLNTVFLSMVMEAIPFVLIGVLVSGLIQMFVTEKWIAKVMPKNRFLSTVLGCGIGVLFPSCECGIVPITRRLLGKGVPLNAGIAFMLTGPVINPIVLFSTYIAFGNDWTVVFVRAGMAIAVAFCVSLIIALVFPQLPMRIGADNPAPVAATVDHAVVPETRASAGKRLYSVLTHAIEEFFDVGKFLVLGAFIAACMQTFIPTSSLMHLGSNPWTASLVMIGLAFTMSLCSEADAFIASSFRSTFSMGALSAFLVFGPMIDIKNTLMLLGTFRGKFVAVLIALVTVFTLLGSIIVGRLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMD8</accession>
    <name>A0A398CMD8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Undecaprenyl/decaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_21540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01037">
        <property type="protein sequence ID" value="RIE01037"/>
        <property type="gene ID" value="D3H35_21540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="315" mass="33962" checksum="C0D2ACEAEEA6B046" modified="2018-12-05" version="1">MIYLYALVFAFTLVIVLVPIVRVAALRFGFVDKPSRRKIHSEPIPLSGGVALFAGVMVTSFVFMGDIPLFRTLLIGGALLVLIGLVDDGFKSRALEFPVWPRLIVYIGVALIPWWQGITIQGVSSPSSSSMILFSPAWAAFFTALWVFALINMMNFIDGIDGLASGVSVISSMTLFAASLLGNQSLTALVTVALAGSCLAFLAYNFHPARIFMGDAGATFLGFTLAVTSVEGTLKGATFLSLFVPMLALGVPIMDTAIVFTRRLLEGKGLHRADNLHTHHSLMKWGLTQVQTVSFLYLVAAVFSLLSIVILLALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMG1</accession>
    <name>A0A398CMG1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphopentomutase</fullName>
            <ecNumber evidence="4">5.4.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Phosphodeoxyribomutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">deoB</name>
        <name evidence="6" type="ORF">D3H35_05485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphotransfer between the C1 and C5 carbon atoms of pentose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27658"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-ribose 1-phosphate = D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:18793"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="5.4.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 1 or 2 manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphopentomutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.7" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04546">
        <property type="protein sequence ID" value="RIE04546"/>
        <property type="gene ID" value="D3H35_05485"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043094">
        <property type="term" value="P:cellular metabolic compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16009">
        <property type="entry name" value="PPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00740">
        <property type="entry name" value="Phosphopentomut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010045">
        <property type="entry name" value="DeoB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024052">
        <property type="entry name" value="Phosphopentomutase_DeoB_cap_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21110">
        <property type="entry name" value="PTHR21110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001491">
        <property type="entry name" value="Ppentomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143856">
        <property type="entry name" value="SSF143856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01696">
        <property type="entry name" value="deoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="5">
        <location>
            <begin position="5"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="391" mass="42635" checksum="ECF829CE9951DA4D" modified="2018-12-05" version="1">MTFDRIAVIVLDSVGIGELPDAADYGDAGSHTLGHIVERVSAVELPNMRRLGLANIAKLGSWEPEAAPIGHYGKMAEVSAGKDTMTGHWELMGLRIETPFRTFENGFPAELIAAFEEETGRSVIGNKVASGTEILDELGEEQLNSGAWIVYTSADSVFQIAANEDIIPLEELYDACRIARRLTMKEEWSVGRVIARPFVGKPGSFKRTPNRHDYAVKPPLPTVMNELKNEGLDVVAIGKINDIFSGEGITKAVPTKSNAHGIEETIAALKTPFRGFLFTNLVDFDSLFGHRRDPEGYAGALVEFDQALPKLMDTLGERDLLVVTADHGNDPTHPGTDHTREYVPLLLYSPAFREPGDIGTKATFADLAATIADNFGAAFRTHGRSFLDQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CML3</accession>
    <name>A0A398CML3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-layer homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_14790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02028">
        <property type="protein sequence ID" value="RIE02028"/>
        <property type="gene ID" value="D3H35_14790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="122"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="929" mass="96656" checksum="F06A18972F5767FC" modified="2018-12-05" version="1">MQQTSIIDNALLRRGGETSMRDSSSNSSKKTSTQKFSQGGEKKVMKKSLPVLLSAALAVSAFASFASAAELTAQEKFDALKAKGIFAGLANGEAGLDQNMTRAQFARVAGLLKGLNVDAQPSVQTYSDVPAAHWAYQEVEAATAAKLFEGKGDGTFGPQDNISVQQLAVVLAKALGLTPVEGATVEGADAWAAGYIKAVQNAGFVLPTNYTANATRGLLVEASYTAVDILNPSTIAVAKTSQTGAKKITVEFNRALTTAEETALKVEVKNGLVPYSFTTAVAADKKSAVLEFSFLPAADYSVKVNDFDAVTVKVVDETVSKLEIATGSVQKVANQKIDVVATNQFGEKVENASLTTTVVGKGSTIALSGGAYDLSALAKDDVVIVTATHPATGITATKTFKITDASQVTQLSLGPVVPLKDKTRITSKDEGLVLPYSFKDAAGNAYKLPAGEGEYEEGSNTVKIGDYQFIISNIKIVNPDSFSVDDDGVLTFDAVAATPAQSEAGTVVITVLNAAAGATANTSVKVEEAQKVKTFQLSAPSSIVAKEEGVKFAFVAADNYGAPIDSKEFAKSDTNSQVTFTTNRGEAVVVSKGYNYKGELTLTFTDGVGAAVTGTTTVYAWIGGAIASQVTVDLKAKAVPNKVSVVKDLASVYGIAGSDVVELSSVKVIDNYGREMSDLGDADLVVQLKSGATTGIVSSAELLNNKIVGVAAGSTKLEIGLDLDGGTTISSGTSIDVSVTVVADDKVASFAVEDPGLFFANADNDEETNAKTLTLVGKTAEGKKIAIDQGRYFTAVTSSDTTLFNTDYETVWSIAKGEATITFWKDASKLAEVKVTSSDAKKAAKSIKFKEAEYTYAEEATIDVASLLEIKDQYGADFGPTVYFSSSDATKVAYADGAWSAVAVGTATITAVTSNGLVATTTIIVNDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMP3</accession>
    <name>A0A398CMP3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_21285</name>
        <name evidence="4" type="ORF">D3H35_26030</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000046">
        <property type="protein sequence ID" value="RIE00861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00861">
        <property type="protein sequence ID" value="RIE00861"/>
        <property type="gene ID" value="D3H35_26030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03111">
        <property type="protein sequence ID" value="RIE03111"/>
        <property type="gene ID" value="D3H35_21285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="273"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="522" mass="57575" checksum="AA4B1DDABF9D1DDB" modified="2018-12-05" version="1">MADGKGGVLVDAEGVYFLGVDIGTYESKAVLTNLEGRIVHHEVISHQMIVPKPGLAEHDADGVWWHDFCLLVERILQATRISSDQIKAIGCSAIAPAVLPVDREGKPLRPAILYGIDTRAVEEIRELEHRFGHANVFQRCGNDLSTQAVGPKILWIKKHEPEVYAQTARFLTATSYLVYRLTGKFKVDHYTAGAGFTPFYDCQQHAWYPEFCKDIVEIDQLPEIGWTTDIAGVITDEAAQLTGLSRGTPVIIGTSDAAAEAVSVGVVKPGQMMLMYGSTAFFIEVTNEPIQDSRLWSAPYLFPDTYALLGGMSTTGAITRWMRDQFAVDLVKAEQYSGKHAFESLMGEAVHIPPGSEGMVTLPYFSGERTPIQDPMASGVVFGLTLAHTRGHLFRSILEGVGYGINHHLEVMKEIGAMPSELVAVGGGTKNELWLQIVSDIAAEVQKVPKVTIGASYGDAFLAAVGSGHLQPGILSEWVQYDHEVTPNRLEHQKYMPYYSVFKDLYQSTKSLMHRMYELRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNE6</accession>
    <name>A0A398CNE6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavin-nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_03605</name>
        <name evidence="2" type="ORF">D3H35_19665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02848">
        <property type="protein sequence ID" value="RIE02848"/>
        <property type="gene ID" value="D3H35_19665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04886">
        <property type="protein sequence ID" value="RIE04886"/>
        <property type="gene ID" value="D3H35_03605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="208" mass="22957" checksum="847BFC193062ACCA" modified="2018-12-05" version="1">MRRQEFEVSEKAECEAFLREKNDGVLTFIGGEDGWPRAVPLNYVYLDDAVYFHGSKQGEKMNGLAADPRAEFVAYEAHAFIPSHFSDPYLACPATVFFRSVRIRGTVEQVEDAAEKAAALGALMANMQPEGGHAPIDAADPKYTSSLRGVSVLRLDAAKMTGKFKFGQNLSAKRREQVLHGLANRDRPGDADTANRVREHAPEIDRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNH7</accession>
    <name>A0A398CNH7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04045">
        <property type="protein sequence ID" value="RIE04045"/>
        <property type="gene ID" value="D3H35_08820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="201" mass="23110" checksum="ED972ABE92FDE169" modified="2018-12-05" version="1">MRKIAALYGGSSQHYRTLNEPKYRQYLQDIVYLPELADTPLSSFDVVLVTSRLHRGLMDQARDKLKAYVEEGGTVVAMTPLPDGWLTQLKWEFRPTNFWWWLDKDASSGLVQLKPEHDLFRYISMGDATWHYHGVFWPKANDEVVIATEDGGAVLFTCREGKGSWIITTLDPDFHFGSYFMPAAEKFLDGFLPWLAEGNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNJ2</accession>
    <name>A0A398CNJ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_24345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01487">
        <property type="protein sequence ID" value="RIE01487"/>
        <property type="gene ID" value="D3H35_24345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005690">
        <property type="entry name" value="GerBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="454"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="543" mass="60199" checksum="66F91AFFDEBC29E4" modified="2018-12-05" version="1">MRFPFFRRRKKRHSGSRDGGKATGSFASNEESGGGGDKKIANPVGMDVNANVRWIREKLGDSRDLVVRTLSEAGTKKAHTAFVFLGTMVDEQIVNQVVLQPLLDLLYGQHKQPSPSERFHLVRNHALPVGQVLEQRSLDEILKQILLGNSILFIAGHPAALIAGTTGGESRSVEEPSSQTVIRGPKESFTENFKTNLSLIRRRLKSQKLRIEYREIGTETMTNVAMIYMEGIAQDGIVREVRSRLDRIDTDAILESGYIEEFIQDETFTFFPTMQNTERPDAIAAGLLEGQVALVVDGTPFVLIMPATFTKFFQSSEDYYQRFDVATFLRLIRYGAFFVSMLLPSLYIAVTTFHQEMLPTSLLISLAAQREGVPFPALFEAFLMEITFEVLREAGVRMPRVIGPAISIVGALVLGQAAVQAGLVSAAMVIVVSFTAIANFVIPSLNMSIAARLIRFVMMLLGGTLGLFGIMSGLMVLLTHLVAMRSFGVPYFSPFAPFIWSNWKDVFIRVPQWAMNKRPRGIAARSNLTRQAKGQKPSPSNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNJ3</accession>
    <name>A0A398CNJ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02819">
        <property type="protein sequence ID" value="RIE02819"/>
        <property type="gene ID" value="D3H35_19495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="104" mass="11681" checksum="DC4F07F4376508AB" modified="2018-12-05" version="1">MEDEHDINQQLYAAAERMKNSITRLQASCRHLSLSAYESPLRMLLAETETMLLRTKPRKAMAPAPYAGYGKTIALPAKGTFTLFFPSPTLPESMFTKGTTITRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNV2</accession>
    <name>A0A398CNV2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF445 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_08700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04022">
        <property type="protein sequence ID" value="RIE04022"/>
        <property type="gene ID" value="D3H35_08700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007383">
        <property type="entry name" value="DUF445"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04286">
        <property type="entry name" value="DUF445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017410341" evidence="2">
        <location>
            <begin position="25"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="432" mass="48989" checksum="F7CA4175444F10CC" modified="2018-12-05" version="1">MKKTANLVLLLVALAFGAAVLCKAWWPDQWWSTLLFYMSEAGLVGGLADWFAVTALFRRPLGLPLKHAAIIPNNRLKLIDGAVQMVETQLLPPNVMKESIEKYSFVRMAVERLDPLVRDGTVYRIGWKALLSWFESMDRPATAAMLDKLLRQGLRTVPVTPYAGKSLSALIDSGLLEKGFDRLLDEIAIKADSEDVKQGIRSMLETEKQRKLNEGGWLSRLFKQTAVSFAESADILNLDEAASIVQRDLLAFLEDMHRPDHEMRTFLLDRLRRLADSLNDDPDIAKAIESWKETTLERTEFSKAIEDLLGRTAQALADGEAERMKEWLERLITRYWDVFKDNASMQNAMERHVKSFLSDVVDREHRLIGTVVRETLDSFTKDKLNEFVESKVGRDLSRIRINGSVLGAFIGACMYVILHVVYDPILRAFGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP65</accession>
    <name>A0A398CP65_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helicase SNF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_02110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05186">
        <property type="protein sequence ID" value="RIE05186"/>
        <property type="gene ID" value="D3H35_02110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013663">
        <property type="entry name" value="Helicase_SWF/SNF/SWI_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08455">
        <property type="entry name" value="SNF2_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="53"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="642"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="915"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1083" mass="123246" checksum="38AEFC87EB4ACE4E" modified="2018-12-05" version="1">MGSQLTKQTIKTLCDRLSYERGEEYFRAGKVTFTNVAPGLGIYEASVKGNGVYDVRIEFDSNGNVEAECSCPSLASYNKYCSHIAAALLHIQSIEPDIGRKSVSGAAETDNDAALVSAMLGLFGDKTLRPPSGTRALFDTREPLDVEFTCKPVAYGYCKFMLGIELKVGPKRLFAVQKLRDFLERVDRGETYVFSKSFAYDPMRHSFQSDNDAVLRQLISIYRNEKLYRDTSDAATAQAFGISGERMLLVPPSAWSALHPRLAAAPAVKLEQDDRTYDGFRLSDEPLPIRFAFDREKDDAYLLDVQGLDGITVMDAYGVVLFEGNLLKLKPESCQRLSELKQTLDSTRKHRIRISRNQIEPFMEKVIPGLKKLGSVHIAQSVSDRIVHTPLQARLYLDRVRDRLVAGLEFQYGDLIVNPLEENDRRRGTDHIVMRDGEREGQILELMEQSSFAKTEAGYFMEDEEAEYEFLYRVVPELEKLLRVYATSAVKTRLHIGNSPPKVTVDADERTDWLDVRFDIEGIPESEIKNVLQSLEEKRNYHRLPNGALLPLETAEFQEMIAFMNEVGIRQLDAIGNAFRLPALRGLRLLDSKLEGHAVKFGKSFRRLLENMRNPDNFDFSVPIRLVSVLRDYQKFGFQWMKTLAHYRFGGILADDMGLGKTLQSIAFLVSVLPEIRKEKVPALIVAPASLVYNWRNELKKFAPEIRAVIADGTKEARNKALNHSSRTDVIITSYPLLRRDIEWYATRPFHTLILDEAQTFKNYATQTAQAVKTVEARYRFALSGTPIENRLEELWSIFDAVFPELFPGRREFGELSREAVSRRARPFLLRRLKTDVLKELPEKIETLQASELLPDQKKLYAAYLAKLRKEALKHLDTESFGKVRIKMLAGITRLRQLCCHPALFVEDYEGGSAKFEQLLELVEECRSAGRRALVFSQFTEMLDLIGRELVSRGVPYFYLDGHTPAAERVNLCDRFNDGERELFLLSLKAGGTGLNLTGADTVILYDLWWNPAVEQQAADRAHRIGQRKVVQVIRLVAQGTVEDKMYELQTRKKKLIDEVIRPGQEELSSLTEQEILEILKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPD0</accession>
    <name>A0A398CPD0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF2252 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_08685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04020">
        <property type="protein sequence ID" value="RIE04020"/>
        <property type="gene ID" value="D3H35_08685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025883">
        <property type="entry name" value="Cadherin-like_b_sandwich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041278">
        <property type="entry name" value="ChiW_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
        <property type="entry name" value="PTHR39441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12733">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18683">
        <property type="entry name" value="ChiW_Ig_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
        <property type="entry name" value="DUF2252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017378796" evidence="2">
        <location>
            <begin position="35"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="4">
        <location>
            <begin position="27"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="1289"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="1353"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="1417"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1480" mass="153539" checksum="B4346B29E23E63F8" modified="2018-12-05" version="1">MRFNTWKKTAVMALSAAIVSNAAYLPAWTPAAAAAEANHIVISEIFGGGSHNTDSPYRNDFIELYNPTGTVQSLQGWSVQFLKVTDSTSQADNMTVGDGTIGKVTLTGDIQPHGYYLIKLGAGTVATGFSSGSGKELTGENAADTSLNMNKDGGMVALLSSDSDFDFGASSGGAVVDFVGYGGSSGSSKPSRYGGSNPAPKGSAQKSLIRKAVNPSDGSSLSTLTGVGVFKGNGFETAGGDNALDFEVTADKSQVNPQNSSFFEPMAAGAASAADLTVSMDSTTTVDPSNASFVVNATHGTLSKSELAQGADFVLNGLPAGLTATAIAAGTAITITLSGQAAADVLADVPLALVLLPSAFSDIYGASEPISGPVLLKSSTKITGAAADSTVSMSDSAAVSSADNSFAITLVNGTVSNGPIAASHFSISGLPAGLTFAATGDGAKTITFTVGGAAASGVFNDASVSVVIKKEAIVSGATEDSDMIGGIVVKRPSAALLNDAARANAVTEILKSVNAFHSDAYDKSYKYSEMAAKTFKFFRGNAAIFYRDLGTTIPVPTAWKSWSNVDTWIEGDAHTRNIGFFDHNDGEAYFDLNDPDESFKAPFYFDLIRFITSLYITRDDVGAVKNTSTPAEVRQAAKDFLDQYRTTLTAVSGEGNDFENTVRIDESFLLNNGFNYSGYMLKTFYGDAAATPQGEGLLDNLSNRDLLDGNSAKGVKGFTRVVDGQRSFVKIANAADSTTADEKLLAVTASEESELRNGWSGYANLTRLDTASKADYFAIKDMARVIEKGLGSIGVRRYFVLIEGPTAGTDDDVVLDVKQQRTPASIANPFVSLDYSAYASKDAVRTKAAYDYMSAKEDPFVGSLDGSSKTYLVRKISAFDRDYDDKKFGSFTDFKEFLKASAMAYAFAHARADRDSGLGYSFEDSVLPLLNSDWTSIRDTLVNLGEDYAKQVEADYNLFKAVPRASLIDVADLASLAVDAGALSPTFDGGKNSYTLSVANTVSTLTVTPKPADSLATMTVNGDALANGAAKTIALNTGANTVTIVVKAQDQSTKTYILTATRAAASDNNNGNNGNSGNGNGNGGSAGNENGGSGPLVVKANSDGKGNSLAEISGKQIDELIHGLSGGQSAGKEPVIEIQANVDPGTKQAAVKISAEAVGNIAGSQAKRLKIGFGIGSISFDEKAINAISGAAVGEDAIFSVSIVGSANDRPVYELKIAVGGKSVSSFGGGTAAVSVPYTLGAGEDANAIVVYYVAESGEKTLVTNGEFDAATGQILFKVVHFSKYEVAYNKRSFGDIGGSFAKDSIAFLSARNIISGFGDGSFAPKSSVTRADFIVMLAKLAGAELGSYGAPSFQDVASDAYYAKSIAWANGLGIAGGTGGGKFAPKAAITREQMSAIIVRFVSATQQAALPQTAAPITFEDRSEIQTFASAAVTTVQRAGLISGKTIAGKKGVFFAPQKAATREETAVILAQLHRLIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPE8</accession>
    <name>A0A398CPE8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FGGY_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05276">
        <property type="protein sequence ID" value="RIE05276"/>
        <property type="gene ID" value="D3H35_01790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGGY_C" evidence="1">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="114" mass="13111" checksum="4613C9005F727879" modified="2018-12-05" version="1">MLRFLILRVGRNRNIRESMEVFEAEGHAIRTVHLGGGGKRNAVWRRMIGDVFGKDIALLANRDASAVGAKRRKNVRTAALSLERHSVYGRIHSRYRKAYRALNEFYQEEREDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPK8</accession>
    <name>A0A398CPK8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0473 protein D3H35_06955</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_06955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0473 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04332">
        <property type="protein sequence ID" value="RIE04332"/>
        <property type="gene ID" value="D3H35_06955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01448">
        <property type="entry name" value="UPF0473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009711">
        <property type="entry name" value="UPF0473"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06949">
        <property type="entry name" value="DUF1292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="98" mass="11481" checksum="D5E7D670AA36C01E" modified="2018-12-05" version="1">MSDHVHDENCDHDHEHEEAVFVVTDEEGNEHEMVLVYTFETGDRAYAVLLDRNDPEDDGVIFRIEEDGEDEVLVNIEDDEEWERVMKVYEELAAQEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPN7</accession>
    <name>A0A398CPN7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00924">
        <property type="protein sequence ID" value="RIE00924"/>
        <property type="gene ID" value="D3H35_25485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="280" mass="31070" checksum="31460945E27A21AF" modified="2018-12-05" version="1">MKLGMHASAWKDWRDDNATAAIRETKRLGLDFVEIPLTSHEGLRAVAIANNLKEAGLQAVTSALITNQSFDITSEFSENRAAGIDFLKKCVRLTSEIGADFFGGVLYGPHMKLSTGRPSEELMHRAASGLREVAHYAKELGITLGLEPINRYETCLVNTCEQALKLIRLIGEPNVKVHLDTYHMNIEEKNVSGAIRQAGSLLGHIHLNESDWGIPGTAHTDWQGIFGALQEINYAGYASLECVIELDGGYVWRQLAPDNRTLAEEGIRFLKGMRDQYFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPR3</accession>
    <name>A0A398CPR3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_05845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000026">
        <property type="protein sequence ID" value="RIE04525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04525">
        <property type="protein sequence ID" value="RIE04525"/>
        <property type="gene ID" value="D3H35_05845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="79" mass="8478" checksum="3D4CA255D3D3CC1D" modified="2018-12-05" version="1">MEAELREIASAGQEIGARIEELAALVEETEAISEASADRSQEAAGIAEFQSNSVRGVADAMGSLTQRIAELERAVNRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPV0</accession>
    <name>A0A398CPV0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEPN_Cthe2314 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02768">
        <property type="protein sequence ID" value="RIE02768"/>
        <property type="gene ID" value="D3H35_19200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041394">
        <property type="entry name" value="HEPN_Cthe2314"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18730">
        <property type="entry name" value="HEPN_Cthe2314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN_Cthe2314" evidence="1">
        <location>
            <begin position="53"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="236" mass="27797" checksum="FC5FFC61E3F95A31" modified="2018-12-05" version="1">MLRILLGEQPSEWDEHTRETVQAIESFILLAGNYAKRRSEKAANFRKFAVRAEGVLRSLDELEQSKYVALRYAERIEHSRLTEMSPDEKLDYDRHVYFDKNAYIRVFSLLDKLGALLNDFLELNTSRMKPQFSYFTVLRNMRLNGLHSELFPKLDEIKEKFREPMSRLRKRRNMEIHFMNAELQDDIVAVGEKASDRSHLENIHANMADLDCGWAMVSDSLRLSLQYSCRRLRAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPW6</accession>
    <name>A0A398CPW6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_05370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000024">
        <property type="protein sequence ID" value="RIE04593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04593">
        <property type="protein sequence ID" value="RIE04593"/>
        <property type="gene ID" value="D3H35_05370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="178" mass="19635" checksum="BFCE93675CC61FCA" modified="2018-12-05" version="1">MEVTIVGRNRAQGAKITAELGVDYLHADLSKMSDVRRLAEQIEGPINALALCAGGISTDKEVRLTNEGLETTFATNYLSKFALSEMLLQQNKIVPDGCIVMVGGNGVHKNASTVWAEPQAGLQAAMKAAFAVDLYASELAKRHPRLRVHTCYPEWFERIFSKRRHCCSDCCLEYSASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPY6</accession>
    <name>A0A398CPY6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pirin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_19430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02808">
        <property type="protein sequence ID" value="RIE02808"/>
        <property type="gene ID" value="D3H35_19430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041602">
        <property type="entry name" value="Quercetinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="PTHR43212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17954">
        <property type="entry name" value="Pirin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="10"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C_2" evidence="4">
        <location>
            <begin position="147"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="234" mass="26285" checksum="A870292A41EFEC5E" modified="2018-12-05" version="1">MINVQRSQDRYSADHGWLKSRFSFSFADYYDPDNMSFGPMRVLNDDWIAESEGFGMHPHREMEIVTIVLKGYLEHRDSLGNRAKTTWGGIQRMTAGTGVHHSEFNVSEEEPLELLQMWFMPGERGLAPSYETTDFDPAELRGAFVPVASSSGVTGKVAHIHQDMTIYLSEAAAGQKLEYALPSGRKAFLFVLEGDLRVNEDTILERRDAARLEGVTELSFASSDGARFMLIDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ83</accession>
    <name>A0A398CQ83_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5590 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_04150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04685">
        <property type="protein sequence ID" value="RIE04685"/>
        <property type="gene ID" value="D3H35_04150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041401">
        <property type="entry name" value="DUF5590"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17881">
        <property type="entry name" value="DUF5590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="SSF54403"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5590" evidence="2">
        <location>
            <begin position="53"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="180" mass="21067" checksum="FDE30D82AB66F388" modified="2018-12-05" version="1">MRASRRTEHNRAPRAMTAGKWVFVIVCFIVFLIVSFVVYIRSSESEYRKDERTAIRIAREQGGLKKIDEALPYTWEESMWIVRGEDERDQIWYVWERKDGIVKKLESEGLSEQQAKQRFSDEYGGDVSPVRIIPAWFDGQPAWEVRYESRTQAGHQAIDFYSFENGAKLKTYELPGTSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQM1</accession>
    <name>A0A398CQM1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="5">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fabG</name>
        <name evidence="6" type="ORF">D3H35_07705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04460">
        <property type="protein sequence ID" value="RIE04460"/>
        <property type="gene ID" value="D3H35_07705"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011284">
        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01830">
        <property type="entry name" value="3oxo_ACP_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="15"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="66"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="158"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="250" mass="26426" checksum="50858BE623EA099B" modified="2018-12-05" version="1">MAHWDLSGKSALVTGASRGIGRAIAIALAKAGADVAVNYAGSEAAAAETVKAIEALGRKAILVKANVGKTAEFDEMVAKTLEAFGKLDILVNNAGITRDNLIMRMKEEEFDDVIETNLKGVFNGIKAVTRSMMKQRYGRIINISSVVGSLGNPGQANYVAAKAGVIGLTKSAARELASRGITVNAVAPGFIETDMTDKLTAEIREKMLTEIPLGRMGRPEEIAEAVLYLASDASSYMTGQTLHVDGGMYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQR1</accession>
    <name>A0A398CQR1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pseudaminic acid synthase</fullName>
            <ecNumber evidence="2">2.5.1.97</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pseI</name>
        <name evidence="2" type="ORF">D3H35_15035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.97" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03138">
        <property type="protein sequence ID" value="RIE03138"/>
        <property type="gene ID" value="D3H35_15035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006190">
        <property type="entry name" value="AFP_Neu5c_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036732">
        <property type="entry name" value="AFP_Neu5c_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013132">
        <property type="entry name" value="Neu5Ac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020030">
        <property type="entry name" value="Pseudaminic_synth_PseI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03102">
        <property type="entry name" value="NeuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51269">
        <property type="entry name" value="SSF51269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03586">
        <property type="entry name" value="PseI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50844">
        <property type="entry name" value="AFP_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AFP-like" evidence="1">
        <location>
            <begin position="285"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="342" mass="37616" checksum="29FE1226BE059E4A" modified="2018-12-05" version="1">MVGPDHPPFIIAEMSGNHNQSLERALEIVEEAARSGAHALKIQTYTADTMTIESDKADFYIEDEGSLWKGQTLYALYEQAHTPWEWHKAIFDKCTELGMIGFSTPFDETAVDFLESLNVACYKIASFENTDVALLRKVASTGKPMIVSTGMASVAEMDELVQTVRAAGCQDLVLLKCTSSYPASPENSNLRTIPHMQQLFDVQVGLSDHTLGIGVAVASVALGATVIEKHFTLNRADGGVDAEFSLEPVEMRHLVEETERAWQGLGTISYGASEREKSSLKFRRSLYVVKDMKAGDVFTADNLRVIRPGFGLPPKYLEMVLGKKVKKDVSRGSAVTLDFILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQW4</accession>
    <name>A0A398CQW4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactate utilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000018">
        <property type="protein sequence ID" value="RIE04945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04945">
        <property type="protein sequence ID" value="RIE04945"/>
        <property type="gene ID" value="D3H35_03365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019516">
        <property type="term" value="P:lactate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004452">
        <property type="entry name" value="4Fe-4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47153">
        <property type="entry name" value="PTHR47153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="72"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="301" mass="33460" checksum="20DA57522613723A" modified="2018-12-05" version="1" fragment="single">MSGTGTVPGTVKERSELALNDEFLRKAVKFTTERLRNGKKNASEEHGNWDEWRERGRQIRLHTIAHLDYYLNLFADNARANGVHVHFADTSAEAVAIALEIAKRKEGKTVVKSKSMVTEELHLNHALEEIGVEAIETDLGEYIIQLAGETPSHIIIPAIHKNRYQIADLLSKEAGETLAPDTQILAGFVRKKLREKFLEADIGMTGCNFAIAETGSMVLFENEGNARMVTTVPKTQITLMGMERIIPSWTDLEVMATLLPRSATGQKLTVYMSGITGPRRQEDADGPEEMHIIIVDNGRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR09</accession>
    <name>A0A398CR09_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01364">
        <property type="protein sequence ID" value="RIE01364"/>
        <property type="gene ID" value="D3H35_23625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019074">
        <property type="entry name" value="YabQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09578">
        <property type="entry name" value="Spore_YabQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="116" mass="12733" checksum="8A7B1D47921F431A" modified="2018-12-05" version="1">MNAAAQWMTIGSMVLCGLSMGTVFDVYRVAARRFHIARWMLPPLDLIYWAAATLCVFAVLLRYNHGKFVCSFFWDSASALPDISDCSADGWSGCRGGCSKRLSGYRCCCGGSFGCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR12</accession>
    <name>A0A398CR12_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1450 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_20860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03228">
        <property type="protein sequence ID" value="RIE03228"/>
        <property type="gene ID" value="D3H35_20860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009910">
        <property type="entry name" value="DUF1450"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07293">
        <property type="entry name" value="DUF1450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="78" mass="8691" checksum="7E62629FF5231728" modified="2018-12-05" version="1">MTASQPANDIRICDKCRHVRVKTLVSKLQKLVPGTEVKVACKSYCGPCQRSAFVFINGRYVTAPTEDEVVEKASKYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR20</accession>
    <name>A0A398CR20_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_23680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nlpA lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01374">
        <property type="protein sequence ID" value="RIE01374"/>
        <property type="gene ID" value="D3H35_23680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30429">
        <property type="entry name" value="PTHR30429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002854">
        <property type="entry name" value="MetQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="279" mass="30658" checksum="52E2DB073990C7C6" modified="2018-12-05" version="1">MRLEQEQQSRFGFAESVRCGKSQRFEQPPASESPSPSPSPEVTLKVGAAPVPHAEILEFIKPALKAQGVNLEVVILDDEGQLNPALKDGQIDANYFQHVPYLDSVKGEKGYDFVVGAKVHVEPIGFYSNKHKSKDELPDGAKIGIPNNPSNEYRALVLLQQQGLIKLKDGLTTYEATPKDIVDNPKKLTFVEADSATLPRALPDLDGAIINTNLVLEAKIDPKTALFREDANSPYANIITIRKGDENREEIKKLNAALTTPEVKKFIEDKYGVAVVPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRH9</accession>
    <name>A0A398CRH9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="6">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="6">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="6">IPP transferase</shortName>
            <shortName evidence="6">IPPT</shortName>
            <shortName evidence="6">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">miaA</name>
        <name evidence="10" type="ORF">D3H35_04580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6 8">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6 9">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04760">
        <property type="protein sequence ID" value="RIE04760"/>
        <property type="gene ID" value="D3H35_04580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6 7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="19"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="6">
        <location>
            <begin position="42"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="6">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="6">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="330" mass="37277" checksum="ABAB59FCA9CE0074" modified="2018-12-05" version="1">MNEPQPDNRPPLLVLVGPTAVGKTALSLQIAKAFNCEIISGDSMQVYRGMDIGTAKLPLDDREDVPHHLIDICSPEHPFSVSEFQSLCTEKIRDIHSRGKLPFIVGGTGLYVESVCYGFRFQERGADEKFRNEMAAFARENGAEALHAKLAEVDPVSASKLHPNDERRVIRALEVYNETGKPLSEIQEQSRGDERRSPYRLCLIGLTMDRAKLYERINERVDQMLEDGLVQEVKTLLSQNVPRGAVSMQGLGYKEIAAYLEGETDLETAVSTLKQDTRRFAKRQLSWFRHMRGLEWADVGAVPKNSELFRMICAIIAGKFHCDMEYIFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRN3</accession>
    <name>A0A398CRN3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_12375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03448">
        <property type="protein sequence ID" value="RIE03448"/>
        <property type="gene ID" value="D3H35_12375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002901">
        <property type="entry name" value="MGlyc_endo_b_GlcNAc-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01832">
        <property type="entry name" value="Glucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017486881" evidence="3">
        <location>
            <begin position="34"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="5">
        <location>
            <begin position="124"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="LYZ2" evidence="4">
        <location>
            <begin position="231"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="340" mass="37306" checksum="9F50CC9A9C7DD6CC" modified="2018-12-05" version="1">MRMNLRKTGFLYMLCVIVIFTMGMSFPAQHVVQSPSPTVNEPQAAAQEEPAASDLSSPFKLFIQPYGLATGLLQARYLAVNAAPSVERLPASSPVIQNEPSKQPIVQEPPETMEYTYEVTAYYLNVREKPNSKSKILNVIKHGTAIAVKRTTDNGWLELEGRGYVHADYAVLKNSKTVTAIAKTDEPVVVLDTIEDPKQPTSAVSSDSGLTEEHIATIFKGTALAGHGLEEAILDIEEEYGINAYFTIAVMKLESGNGKSRLAKIKNNLFGLNAIDGAHNKAFSFETKEDSVHTFGRLLSKSYVGKGYTTIEKIAKKYCPSNPKWPGLVISIMKGDYKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRR5</accession>
    <name>A0A398CRR5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_05245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04870">
        <property type="protein sequence ID" value="RIE04870"/>
        <property type="gene ID" value="D3H35_05245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="187" mass="21335" checksum="AD5CF029B513B1CF" modified="2018-12-05" version="1">MNNRVNMKELFLGMQQEMLSKLNTIRKHVTHSGTKGNATELSWIEWLGMYLPNRYSVDQAFVVDYKGNRSDQIDLVIYDKQYSPFVFFQDGVKFIPAESVYAIFEIKQALNKEHIQYAAEKAESVRALHRTSVPIVHAGGTYPPRPLFNVIAGLITTSSDWNPPFGKPFEESMGRLLRVSILISVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRU1</accession>
    <name>A0A398CRU1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Maltodextrin-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_22065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial solute-binding protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01654">
        <property type="protein sequence ID" value="RIE01654"/>
        <property type="gene ID" value="D3H35_22065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006060">
        <property type="entry name" value="Maltose/Cyclodextrin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006061">
        <property type="entry name" value="SBP_1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00181">
        <property type="entry name" value="MALTOSEBP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01037">
        <property type="entry name" value="SBP_BACTERIAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017099280" description="Maltodextrin-binding protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="421" mass="45092" checksum="8EA83F531ABF9D11" modified="2018-12-05" version="1">MVLLLSVGMIAGMTACSKANNENKPASPSASVSPSASGSSVLEPEPGAELTIWDSEGNDGGLWLKKVLPGFTEKYGVKVTYEPVAVDDVPSKIATEGPAKLGADVFNAVHDALGGLVSAGLVYPNDTLKADDLVLPAVQGTAYGGKQYGYPVAIETAGLYYNKDYVKEPPKTFDEVISFAKEFNGKGKYGFMMETSNFYFVNSLLSGYGGYVFGKDGTDKDDIGLNNEGAVQGAEFFRSLKSILPVNASDLKEDIKKGLFIEGKVAYNIDGPWNLQGYKDSKINFGVAPLPLLPNGKPPVTFSGVRAFYVNSYTPYPKAAKLLASYLTSEEMLMDRYLTIGQIPPYKELLAKPEVSGDPITAGFAAQIENSIAMPSIPQMGAIWEPAASALEEIWNKGSDPKTQLDRAVKSIKDAIALQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRX2</accession>
    <name>A0A398CRX2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_01370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000013">
        <property type="protein sequence ID" value="RIE05303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05303">
        <property type="protein sequence ID" value="RIE05303"/>
        <property type="gene ID" value="D3H35_01370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="91"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="306" mass="35116" checksum="921D9300DDC5366F" modified="2018-12-05" version="1" fragment="single">MDDGQGKYRGFQPHTKNFFSIAFPRLWRDRYIYLLLLPGLIYFLMFKIIPIFGNVIAFQNFNPFKGIMESDFVGFANFQRIFEDSEVLRVLRNTLFISLMQIVFVFPAPILLAIMLNELANERIKRFIQSIVYLPHFFSWVVIISIATIFLKPEGLINQLLMYMGYDWVSFMTNSHLFVPIVIVELIWKETGWSTIIFLAALASINHELLEAAIVDGANRWKRIWHIIVPSIGPTVVILLILRLGTVLDSGFEQIFLMLNPFNKEIGNVLDTFVYEKGIKQSDYSFSAAVGLFKGLVGLVLVLGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRX7</accession>
    <name>A0A398CRX7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactate utilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000018">
        <property type="protein sequence ID" value="RIE04940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04940">
        <property type="protein sequence ID" value="RIE04940"/>
        <property type="gene ID" value="D3H35_03330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019516">
        <property type="term" value="P:lactate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004452">
        <property type="entry name" value="4Fe-4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47153">
        <property type="entry name" value="PTHR47153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="72"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="305" mass="33874" checksum="5911E57570DA5752" modified="2018-12-05" version="1" fragment="single">MSGTGTVPGTVKERSELALNDEFLRKAVKFTTERLRNGKKNASEEHGNWDEWRERGRQIRLHTIAHLDYYLNLFADNARANGVHVHFADTSAEAVAIALEIAKRKEGKTVVKSKSMVTEELHLNHALEEIGVEAIETDLGEYIIQLAGETPSHIIIPAIHKNRYQIADLLSKEAGETLAPDTQILAGFVRKKLREKFLEADIGMTGCNFAIAETGSMVLFENEGNARMVTTVPKTQITLMGMERIIPSWTDLEVMATLLPRSATGQKLTVYMSGITGPRRQEDADGPEEMHIIIVDNGRSLQLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSG9</accession>
    <name>A0A398CSG9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03688">
        <property type="protein sequence ID" value="RIE03688"/>
        <property type="gene ID" value="D3H35_10340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="142" mass="16151" checksum="61A5E6C4B2E32701" modified="2018-12-05" version="1">MNRNELLLSYVEKSLMHKRIFETEWYRHNTMDLSSTQTAALSIIAKKGPLQAKELGLQLSLSSGGITTVCDKLLSRGLIRRLRSDGEDRRAVFLETTEEGRAMVIRTDAVWEQVLNVIFSVLTDAEIAMLHQIYSKLVDPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSJ8</accession>
    <name>A0A398CSJ8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Signal peptidase I</fullName>
            <ecNumber evidence="4 5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lepB</name>
        <name evidence="7" type="ORF">D3H35_10510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 5"/>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03718">
        <property type="protein sequence ID" value="RIE03718"/>
        <property type="gene ID" value="D3H35_10510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="6">
        <location>
            <begin position="111"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="234" mass="26552" checksum="2483C28C4671ACD1" modified="2018-12-05" version="1">MLERKRRPLVAGFLSLFTPGLGQFYNGQIRKAGVLLLTTYILYPPLLFLIKFSFGALLAVIAAGFAVYGYAIIQSIVYSYRVKTVANRFYDRWYVYLAIVVSIMTMSQIIDTKSIVGLKGYIIAGPSMTPTIENNERVIVDTKSHRYKEGDVVVYRSENQMRIHRIIAIEGDTVRFDDSGLLLNGKRVTETYISESDYYEAIEEVQIPEDSYYILGDNRGNSYDSRFIGAIPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CST9</accession>
    <name>A0A398CST9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02877">
        <property type="protein sequence ID" value="RIE02877"/>
        <property type="gene ID" value="D3H35_19850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025689">
        <property type="entry name" value="Spore_YtrH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14034">
        <property type="entry name" value="Spore_YtrH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="108" mass="11545" checksum="B438E3C65F21A1C1" modified="2018-12-05" version="1">MELVYTKMAFSFFIAFGVVMGGALLAGAGAVFLWTPPKIEMLKVAGNLKIWALVAAVGGTIDPMRVIESNVLQGHLSLAAQQIIFILFAFLGAHMGTELIQWMCKSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT48</accession>
    <name>A0A398CT48_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Competence protein ComFB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02491">
        <property type="protein sequence ID" value="RIE02491"/>
        <property type="gene ID" value="D3H35_17495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019657">
        <property type="entry name" value="ComFB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10719">
        <property type="entry name" value="ComFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="94" mass="10205" checksum="F3A8E5FF653A46E6" modified="2018-12-05" version="1">MKLSQELSVLNAMEPIVISTFETHMLGSASLSCSCNKCQLDIVLLALNHLPPRYTSSQAGEAYIKAQYMDPQLQSDVLKELAKAASVIGSNPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTF6</accession>
    <name>A0A398CTF6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Electron transfer flavoprotein beta subunit/FixA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02244">
        <property type="protein sequence ID" value="RIE02244"/>
        <property type="gene ID" value="D3H35_16040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="1">
        <location>
            <begin position="23"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="278" mass="30217" checksum="7D872A3385284355" modified="2018-12-05" version="1">MLHIVACIKQVPDTKIIKMNPKTNTMDRSSAPAILNPYDSHAVEEAVRLRGRYGGVVSVLTMGPPPAVKAIKKCIEIGADEGYMISDRAFAGADTLATSYALTKALEKIADIRPIDLIVCGKMTIDGDTGQVGPGIARRLDIPPLTSVNKVVEVNKEEGYAIVHRKLEDGYEAIRTTLPCLFSVEKEINEVPYSPLPNMLRAARYQPHIWSVGDLPDIDRPQLGLKGSPTIVSSVWAPQKPQGGKLLEGDSAADRVRQLLDIVLERKELFEAGQGAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTW2</accession>
    <name>A0A398CTW2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Semialdhyde_dh domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02404">
        <property type="protein sequence ID" value="RIE02404"/>
        <property type="gene ID" value="D3H35_16990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="1">
        <location>
            <begin position="98"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="300" mass="32284" checksum="48C6E536F79E3824" modified="2018-12-05" version="1">MSEPIGWVLAVPLSAKQMLELPPKKVVSKIEEAIKKAAALGADIIGLGALTSPVTMGGQKLLKRTNLSITNGNALTAVMTCEGIVRLIEQCPTPAPAIAVIGASGSVGSCLVRMIASNRLTEHLILVARNMNRLNKLSESIRQDNRDIDVRTSYDMNVVREADIVVLLTSSSDNLLQPEHLKEGALVLDDTQPRNTDSTLLSRRPDITIVDGAMVDINGIVINGDINVPSGLAYACLAETMLLALEGHPAHFSIGNPTLEQANYIGTLAQKYRRYGFSLAPFHSFGKKLPHDNPTYEVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTZ6</accession>
    <name>A0A398CTZ6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">dnaJ</name>
        <name evidence="11" type="ORF">D3H35_06035</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04178">
        <property type="protein sequence ID" value="RIE04178"/>
        <property type="gene ID" value="D3H35_06035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 7 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="10">
        <location>
            <begin position="129"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="7">
        <location>
            <begin position="142"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="7">
        <location>
            <begin position="159"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="7">
        <location>
            <begin position="185"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="7">
        <location>
            <begin position="199"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="8">
        <location>
            <begin position="129"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE04178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="372" mass="40325" checksum="1235EC1167109FFD" modified="2018-12-05" version="1">MADKRDFYDVLGVNKGASADEVKKAYRGLARKYHPDVNKAADAEEKFKEVKEAYDVLSDDQKRARYDQFGHQDPNAGFGGGGGADMGGFGDIFDMFFGGGGGRRDPNAPQRGNDLQYTMTIEFKEAVFGKETDINIPRTESCDTCHGNGAKPGTKPETCTVCRGSGQQEVAQNTPFGRIVNRRACSACGGRGKIIKERCGTCAGAGQVKKQRKINVKIPAGVDDGSQLRMSGEGEGGVRGGPAGDLYIVLRVKSHDFFEREGDDIYCEIPLTFVQAALGDEIEIPTLTEKVKLKIPAGTQTGTFFRLKGKGVPKLRGYGQGDQHVKVAIVTPTQLSDSQKELLREFGATSGESTHEQHQSIFERMKKAILGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUA1</accession>
    <name>A0A398CUA1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LPXTG cell wall anchor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03427">
        <property type="protein sequence ID" value="RIE03427"/>
        <property type="gene ID" value="D3H35_12235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="38" mass="4156" checksum="BD1D67A9FC0B8590" modified="2018-12-05" version="1">MNDSAVQSEFSLSATLTFAVGLVLVIGLAISLYKRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUA4</accession>
    <name>A0A398CUA4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_19680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02851">
        <property type="protein sequence ID" value="RIE02851"/>
        <property type="gene ID" value="D3H35_19680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="178" mass="20537" checksum="BF0BFFA7DD52D962" modified="2018-12-05" version="1">MVDNEWSRLEEIDWLFRRMVRKFVKERDKIAIEGVALPGMLVLSKIVRDGEQKLGDLAEQLDLTSGAITALCDKLEEKGFATRRRMAEDRRTVLLDITDKGRSLLARNRNISQRSITLLFGGFTEQELDSQRAAYKQITDSLESFSETILKLAKENAERSEEREEPQIKPSANRFLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUP0</accession>
    <name>A0A398CUP0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RHS repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03577">
        <property type="protein sequence ID" value="RIE03577"/>
        <property type="gene ID" value="D3H35_11105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017254120" evidence="1">
        <location>
            <begin position="41"/>
            <end position="1593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1593" mass="180437" checksum="81B9E2BA95A44725" modified="2018-12-05" version="1">MNFFIENYKNEENESGMKKRLSAIVLSFAIMLSSFQIADAEQTVPEAVASQTNSVRSEVQNGTVNNDESGINSVFSDQQLKSIKERFTSEMRLLSAYYYPELVSSLSQEELTIFLSLDDAKLKKMYLQLSQDQQANLERLVPLVKQYLVPQVSKNIQSEATERSLNGNSKASTSINATAAAASTEYSYSPKDAGFNYQQSFEGDVDPVSKSFNQSDIDLFLKGDVGLDIVLERSYNSSSSFFSRPVVSCCDSNQPYDFVQDADLNNTTSAQPASYGVNEIAPGWELNIPIMTIGYFDKYGIYKKETNNSKYEFTTFYGYNVGYSRFQLDDGNTYTFASSTLLNSTYKNVTYSETKDDYVITVDDNVSYYFDRATMRIKMKRNKKGNFVTYTFKNYPSTSTLEKLTIDPLGQPFYVDILLSGKKVSGFQVFDRTNTLIKHVKYNVPRTTTTTPLTIRKLTRETTIAAGLAYYQLESVVDVLQNKTLKAYTYYNPTQTLADFNLEDDWKYFIDQNGNYILDVKDRNGNGVESAEVVRLNKGYYGEVAYLLLKEITDYTGFKTTVQYSTYDRSWPQYTDYEESEQKRGTIRSYGDLNLLQYIGYLPVVNVFYSYTDANGQTKIYTNNYQRDYSRAQEIWNRPKSVTPATTYLPAHRLVNASSYRNGDIQSSSMTQIYEGFSTSAKREFRVTSKGTFKLLWEKQINQLPQNNLNVTDGSNNISYSTENITAYQYDEGTNKPYLIKSLNGGQGNLVNDFGRSLPGNIANFANIQKLEYNDYGDVIYKEDTLGNKMTAQYDGIKHQVSYQSIVSADGKSKTENTFEYNTDSTIKKITTKQTYNDPATQLPVVKSSTEEYVSYNVRKMPTQVIVTADGSTQVINYLYDTRGFLVIKETVSVKLSDGTLKTEVSNSYTYDSLNRVTSQTYPDGSKVVYTYDSLNRKLSESFIPSTGGGTRTIQYTYDDSNRTITKILPDGEKIISTYTPYGTEEKIQRAIGSNTKVIQTKIFDSTGMVVKATLPYNDPTKGEYYSYGEDGQIQTVTNALGQSSNYYYSNSVTATDGSLSLPQMTSKTVDQDGKETWSYADRAGRVVKQVEKSGSKTRTTLQDYNGAGQVTKRQVISNGQLQTTWFEYDAVGNLIYVRDEKGQQYKYTYNSSNQLESISINGVLQNQKQYNELGWLLKSTNANGQAKNYQYRTNGLVEKVIDEEGQISNYSYTPYNEQERLSVKNATGTELYWLQNTFDPTSRLVTGITNSENETLTYRYDSWKHLDQQTVAGKKYSFAYDAFDRLSTVVYPDNAAVNYSYDALNRISTVSYPDMGVVSYGYNVSQNANKYTVTYPNGLVQEKLIDGFDELVSVTHSRSSSAPEWTESFGFDSFGNIETINRNGQIFNYLYDGLNRISTDVSSQKEYHYDDRGNIQSFEQNGQTYSFAYDNSNRLTQAALPSNTINFTYDNRGNRLTANSDTYTYNSLDQLKTFTNGTNQALYTYYGDGLRATKKVNGVLTRFVYLNGRVIDELDSNGNSKARNIWGNELIFRKDNATNQKGYYSYNGHGDVVRITDAAGTAINSYDYDIWGISQAKRKGCPTFQIYRRDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV66</accession>
    <name>A0A398CV66_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_02075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05179">
        <property type="protein sequence ID" value="RIE05179"/>
        <property type="gene ID" value="D3H35_02075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="42" mass="4414" checksum="6BB93B08B87A33D3" modified="2018-12-05" version="1">MAVTTRAAGVSSQIMTFQYDAAGNLIAETDPNGNQTVYGYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVC6</accession>
    <name>A0A398CVC6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aromatic ring-hydroxylating dioxygenase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_07760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04468">
        <property type="protein sequence ID" value="RIE04468"/>
        <property type="gene ID" value="D3H35_07760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="52"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="410" mass="46334" checksum="D9A8D03BD490A74F" modified="2018-12-05" version="1">MAYKPNEEVLGVISQLGPSLIESKEARSLPAECYTSPSFFEFEKEAVFARSWLCVGRQEMIPNAGDYFTIKINEDPLIVSRDSKMNIHVISAVCQHRGHLVAEGSGNCKNFRCPLHWWTYGLDGELVSAPEMIRIEPFDILRHDHSLPGLKTEIWNGFIFCNFDPDAAPLAPTLTKLDEEMANYRVNDLVSMPFVDIDDCRWNWKIMIESSIEPYHTNYLHKGPHDFAPSQLAGFIDYEDGDGQIMHPTGFTHIDAGFSPEMKANFPAISTLTDEQRQRMTIATVPPMLTLGLMPDQVFWNIILPQGHDGILFRSGLMYPPETVALPDFEERYKLANDSIQEINEQDLAANASLQKGLSSRLASRGRYAALERTLPQLNKWLAKKYYGYLEDKGIELEPPKAFAEAKAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW73</accession>
    <name>A0A398CW73_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NlpC/P60 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_12445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03461">
        <property type="protein sequence ID" value="RIE03461"/>
        <property type="gene ID" value="D3H35_12445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017248721" evidence="2">
        <location>
            <begin position="37"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="39"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="159" mass="17188" checksum="9A96EEE59413065D" modified="2018-12-05" version="1">MNKRYGKTMAGIALGLAIMAGGTITTVGYAPSHAAAATASQASGIIQTGKQYLGVPYKFGAKTGNTSRFDCSSFTQYVFARNGIHLPRSSKQQSKVGTYVPRNQLRPGDLVFFYSPIHHVAIYLGNGKLLHTFGKPGVTITDLNSGWWSSHYTTARRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWD1</accession>
    <name>A0A398CWD1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03521">
        <property type="protein sequence ID" value="RIE03521"/>
        <property type="gene ID" value="D3H35_12110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="327" mass="35935" checksum="76EEAF62E21ED70A" modified="2018-12-05" version="1">MIRFGVIGTNWITDRFVQAAGHCENFKLTAVYSRTEAKGREFADKYGAAHVFTDIAELAGCSEVDAVYVASPNSMHSEHAIECMKRGVHVLCEKPAASNAAEFERMSLTAREHGVLLMEAMKSSFLPSMNAIRDNLSKIGPVRRYSGGYCQYSSRYDSYKEGIVLNAFKPEYSNGALMDLGVYGLYPLVLLFGEPQSLTASAYLLESGVDGQGTILAKYEGMEAVVPYSKISDSAVANEIQGELGSILIDKISEPGRVTIQYRDGRSEQIGSVADKPSMFYEVNHFIECIRSGKIESDVNTHATSLAVLRMMDEARKQIGLVFPADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWM6</accession>
    <name>A0A398CWM6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTP cyclohydrolase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_12215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03424">
        <property type="protein sequence ID" value="RIE03424"/>
        <property type="gene ID" value="D3H35_12215"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="7">
        <location>
            <begin position="79"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="251" mass="28155" checksum="601DBE28AC9C8A3E" modified="2018-12-05" version="1">MSVKQAIDPKVIDILKPKIKLIRSDKGAIYLVGPIRLPVKLEDETVIFQWYCWLNCEEVTDDTERIIEKLSSINLAEFQQSSVLVYGDFEAADDALIRFHSICHTGDIFGSKRCDCGFQLKQSLKLIADHGSGALFYLANHEGRGIGLFSKAMAYVLQENGYDTVDANLSLGFVDDSRSYGDAIHVLKALRSKPVKLITNNPKKLDALRYSGLDVADRVELWGDVSEYNQNYLKTKINRSGHLEEGCCDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWV2</accession>
    <name>A0A398CWV2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03681">
        <property type="protein sequence ID" value="RIE03681"/>
        <property type="gene ID" value="D3H35_10300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="412" mass="48608" checksum="F2C0A1F65C20809B" modified="2018-12-05" version="1">MFNQFLLVIQVFFFLIGAYQIILSFFGWYRKKERITHEPTKSFAVLVAAHNEEAVVGALVENLLKMKYPRELFDIFVICDNCTDGTADIVRSYPGVYACERVNPNQRGKGFAIEWMLKELWKHPKQYDGIVMFDADNLVATDFLTYMNEDLCNGYRVVQGYLDTKNPHDSWVSASNGMNYWFCNRLWQLPRYNLGLSNFLGGTGMCFETKLLKEMGWGATSLVEDLEFTIRCIQRNIYPKFNFDARVYDEKPITFRASARQRLRWMQGHFDITRRYMLPTLWQGIKERSWIKIDAAFYIFNAYNFLLGFLITATLWFDLLLPGQPHFDSIYSLAPNWVAVPIALYIYAQVPLSMLLEKVNWKIYLRLVTFPVFFFSWWPITFHAFFTQNNKTWSHTQHTRVIRLEEVQGKQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX55</accession>
    <name>A0A398CX55_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05158">
        <property type="protein sequence ID" value="RIE05158"/>
        <property type="gene ID" value="D3H35_01960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="6"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="329" mass="36223" checksum="F0C17FA834E3E212" modified="2018-12-05" version="1">MRALKSRNGSAVFVDLPEPPIQPQYVKVRITYSSVSIGTELLMIRTNPEAPLGYSATGIVTEVGEGVTHVKPGQRVACYGTPAHREIMLSPKHLTVPVPDGVSDEEAAFCGIGAIAIHALRQADLRFGETAIVAGAGILGQIIARIAHASNYRVIGLEPLEERRAMLVSTGMTHVCDNESKMKDLLADLTEGKGADAVLVCASNRKESLIDTSLHWLRDRGKVVIVGDTGGEFDRDLLFAKEASIHISRAGGPGRYEADYEKLGFDYPIGYVRWTEGRNVQDFLRMIQERRIDVQSLITDQVAFGELPELYTRYERNPQKMMGIVVRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX57</accession>
    <name>A0A398CX57_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Wzz domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_09565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03791">
        <property type="protein sequence ID" value="RIE03791"/>
        <property type="gene ID" value="D3H35_09565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="7">
        <location>
            <begin position="30"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="276" mass="30949" checksum="2D0421A555AE80A7" modified="2018-12-05" version="1">MYHKLKLHYDTLRSKLCRTIQLLRGGKNMEIEMKRYVSALKARLWIVLLIVAAATASAYMYTKNFTPSYYTANTKLIVNKTIEAFGAEQMDFSSIGTSIRLIETYKQIIQTPAIMDKVVEKYPELGLTANQLIGMVNVYAVNETQVMSLSATDSNYVLAARVVNAVSEVFKAEIPKIMKVDNVTILTKAKENEPTRPYGQNLKLNVAVTFAVSLMLSAGLIVLLEYLDNSIKSEEEIWQLVGVPSFAAIPKMKKRDFKRRYSGPTSKSLQAGEQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ17</accession>
    <name>A0A398CZ17_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04174">
        <property type="protein sequence ID" value="RIE04174"/>
        <property type="gene ID" value="D3H35_05995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="136" mass="14743" checksum="E78367FD70CCCE1E" modified="2018-12-05" version="1">MRRDTFKLLLMAAIVAFAIMYGMELASSGISSVNGPWSSDGKAGAQTKGSVIHSEEEWELPSPTPQDGATAEGKTRRQSSGENDDTIRQPDEVFIPRNDREPIVDRVSAKTATVLHDVSHSGIRIVVSLFEKITGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZX2</accession>
    <name>A0A398CZX2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">8-oxoguanine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.32</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_07740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.32" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04464">
        <property type="protein sequence ID" value="RIE04464"/>
        <property type="gene ID" value="D3H35_07740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102127">
        <property type="term" value="F:8-oxoguanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="56"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="475" mass="52061" checksum="9974BADA73D4A0B4" modified="2018-12-05" version="1">MSTLLIKNAKNIITMDGERRRFPGGSLYAVGQEIVAIGYDLPYETADTVIDATGKIVYPGLINTHHHLYQNLTRNIPFVQKTELFDWLVTLYDIWRHLRPEDIHISAVVGLGELLKTGCTTAADHFYCFPNGVSGELIDEEIRAAQELRIRFHPTRGSMSLGRSKGGLPPDEVCQDEETILRDSRRLIETYHDSNRFAMLRIGVAPCSPFSITGDLLRESAALARSYGVRMHTHLAETQDEDRFCLEKLGMRPLEFMEQTGWVGDDVWYAHGIWFNDAEIHRLGSHCCGVAHCPTSNMKMGSGVMPIVKMLGAGVNVGLGVDGSASNDGSNMLSEARIAHLLHNLMHGTTAIGAEDCLHLATMGSAKVLGWADDIGSLEVGKAADLFMIDSRQLGFAGALHDDGALPVLTGLSQTVDMTIVGGKIVVKDGRLVNVDEEKAAIQAQAASFRLLNEAALRTKIDYSRMRTEGKYPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0C5</accession>
    <name>A0A398D0C5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04614">
        <property type="protein sequence ID" value="RIE04614"/>
        <property type="gene ID" value="D3H35_03730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="307" mass="34596" checksum="938E2A2536192925" modified="2018-12-05" version="1">MEKRLKRSELYFSLTFLLMLIIAIGAFFYGVKVGNEKTESKYAAEAEPKSATASPLPNAYQQQDLVSFYHTVFLPYREFQNAWFEERTLWLNDSTIDRSGSLKTLAKNAKKKYEAVRKAYVAPSSPLLMDAQTNYLKSLKLFEDGFSSLVSTSNEGTVADLMDSLDKNTFYKEAQLQALTGQDRYYSAMLKWGATVNLDIPSEYTAPKSIALAQWNKLPLIIKNKVVADYLFAGRVYSPYLPHDLTARIDQVIRSGQAEKLKLKTVGSIAELLNGTDAVRSGDFLGLKSRLYDEPLLPLLPFFSPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1A6</accession>
    <name>A0A398D1A6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Caspase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05281">
        <property type="protein sequence ID" value="RIE05281"/>
        <property type="gene ID" value="D3H35_01820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="299" mass="33054" checksum="BAC000CD7134ACCD" modified="2018-12-05" version="1">MTKRAVVVGVNDYSVQGPAFSNLKCCVPDAQAVYHLLVDAFLFDPSQIWVYLDSKATSSNIRQAIRYMLSISEPGDVACLYFSGHGGLHSITADTYYQTIIPYSGSYISDWDLALAAESLEPSKVNFTVILDSCQSGGMHEESEHPDAIKSVRYASDFVNRLIASLQKVIPFGVTVPNVQAYSSNVNNVRQGDAALVCMDEDPNQLFIPLAKSTLLSACRWDESAGEPKVPSATANHGYFTQALLDLVNQSGFQIDHRSLHQKVVERVHQLTGSSQTPQIRGQQNRMEEDFLLGWRDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBF3</accession>
    <name>A0A398CBF3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000054">
        <property type="protein sequence ID" value="RIE00486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00486">
        <property type="protein sequence ID" value="RIE00486"/>
        <property type="gene ID" value="D3H35_28120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="148" mass="17180" checksum="04A6636ED6C45F40" modified="2018-12-05" version="1">MHDRQTSRRASGDESIADPQAKGSGIGIRNVNQRIRYIFGKDYGVTSIRFRRRDSRPDPYRLFIAKGGISNVENDHRGRRAVDSGRLEKHAVGTMGLHGRWRSGGRRRRLALVEETRPHFIITDIRMPGMDWARILQDVKERTRKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBR9</accession>
    <name>A0A398CBR9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00220">
        <property type="protein sequence ID" value="RIE00220"/>
        <property type="gene ID" value="D3H35_29745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045919">
        <property type="entry name" value="DUF6338"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19865">
        <property type="entry name" value="DUF6338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="257" mass="29365" checksum="761B9F18C20C05B4" modified="2018-12-05" version="1">MDSLIGTIIFLLPGLLLYFWVQYFGVNPVVKHSPAEFTAITVLLWFPVSASAIYALNWLVRINNSHPFSDIVTSNFTEIWTLTQLKNASDNISYLIAFVIASTVISFVVGLVWAKWIHYPIFTGLVNWVRKSRKLAPLSKSSSVWDEVFLGNDTQVVEVGRIDKKDGPVIYGCIQKASRPFEPERHLYIQHLRDFDLEFIEKNEIEVEGQFYDMKSGSYVKVFNYEMTIKALKKHWGSEAEGLLPPRLKKKRGASGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CC15</accession>
    <name>A0A398CC15_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000058">
        <property type="protein sequence ID" value="RIE00323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00323">
        <property type="protein sequence ID" value="RIE00323"/>
        <property type="gene ID" value="D3H35_29205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="62" mass="6442" checksum="F09169E3F18BC245" modified="2018-12-05" version="1">MNFGKIASPIASRLLVIAGFVFFSIAFVCAFVHSLTVFDSFSSASGAFLAAVIALLAVSALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CC61</accession>
    <name>A0A398CC61_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_28485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00363">
        <property type="protein sequence ID" value="RIE00363"/>
        <property type="gene ID" value="D3H35_28485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="94" mass="10813" checksum="4589243B9E3BCB93" modified="2018-12-05" version="1">MQRKAYSTGIFFMAPITIIIFVFMVYPILQSVFYSLTDWTGIGGYHFVGFSNYKDIFSDEGFTDALKRTLFIGVLTAVLANFFVFFLPYCSINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CC89</accession>
    <name>A0A398CC89_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_26655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00776">
        <property type="protein sequence ID" value="RIE00776"/>
        <property type="gene ID" value="D3H35_26655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024131">
        <property type="entry name" value="UPF0489"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12640">
        <property type="entry name" value="UPF0489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="244" mass="27637" checksum="091AB7C359675CBD" modified="2018-12-05" version="1">MFDNDYRICFPKRNIFISRNHQWAFAAWQLGARSGALNGGATLLHVDAHLDDTWDGVIAEGLHEMKDSDDIMKVAGRLEIDNFIWAGFAAGTIDHIVYVCPKGIDDSDPFDLSSWNLEGEQLKPVKELLARKEYRGRRFESIAAFKGECEKIGGIPLSSDLERPVILDLDLDVFKLRPELPEDGELTPVHQIKEELRFLRDSHEYDMVTVAISPSFCGGDTNGEFLLRMFLETFGLELSEAETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD26</accession>
    <name>A0A398CD26_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1657 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_21940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01086">
        <property type="protein sequence ID" value="RIE01086"/>
        <property type="gene ID" value="D3H35_21940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012452">
        <property type="entry name" value="DUF1657"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07870">
        <property type="entry name" value="DUF1657"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017252523" evidence="1">
        <location>
            <begin position="20"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="68" mass="7380" checksum="B747AA923F7B0126" modified="2018-12-05" version="1">MTVSSQVKTCVASLKSAQASLEQFAISTQNQEAKSLFTNAAAQTQAIVDQVEGRVTQLENEEPQYKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDI5</accession>
    <name>A0A398CDI5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01246">
        <property type="protein sequence ID" value="RIE01246"/>
        <property type="gene ID" value="D3H35_22915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="146" mass="16776" checksum="4EE5EBEBCBD09B29" modified="2018-12-05" version="1">MEPYRMSQSILYLKRTYIIMRKELDVRLSTFNLTTSQFEILGYLAQSGGLEQQKLQHHSGITSATLTGILDKLEARSYISRKPSHTDGRANVVTLTQQGNEVFGKLVDLILEFENEMLKGFTQAERDLLGQWLQRVAKNLGDKEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE46</accession>
    <name>A0A398CE46_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">spo0A</name>
        <name evidence="13" type="ORF">D3H35_26320</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with Spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. Repressor of abrB, activator of the spoIIa operon. Binds the DNA sequence 5'-TGNCGAA-3' (0A box).</text>
    </comment>
    <comment type="function">
        <text evidence="9">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9 10">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00715">
        <property type="protein sequence ID" value="RIE00715"/>
        <property type="gene ID" value="D3H35_26320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051606">
        <property type="term" value="P:detection of stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042173">
        <property type="term" value="P:regulation of sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014879">
        <property type="entry name" value="Spo0A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012052">
        <property type="entry name" value="Spore_0_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08769">
        <property type="entry name" value="Spo0A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002937">
        <property type="entry name" value="Res_reg_Spo0A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02875">
        <property type="entry name" value="spore_0_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="2 9 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0678">Repressor</keyword>
    <keyword evidence="3 9" id="KW-0749">Sporulation</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="5"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR002937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR002937-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE00715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="272" mass="30394" checksum="75DE8C3F8035BFFA" modified="2018-12-05" version="1">MPRIEVFLADDNREFTNLLSEYIQEQDDMTVIGVAYNGEEVIRQLEETRRVPDVMILDIIMPHLDGLGVLEKLRDMNLSPMPKIIMLTAFGQENITQRAVQLGASYYILKPFDMDVLANRIRQLAGNNAAASISSSSSVNSVSGLRSNIVPLGKPKNLDANITSIIHEIGVPAHIKGYQYLREAITMVYNNIEILGAITKTLYPAIAEKFKTTPSRVERAIRHAIEVAWTRGNIDSISHLFGYTINIAKSKPTNSEFIAMVADKLRIEHKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEV5</accession>
    <name>A0A398CEV5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF378 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01253">
        <property type="protein sequence ID" value="RIE01253"/>
        <property type="gene ID" value="D3H35_22965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007211">
        <property type="entry name" value="DUF378"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37304">
        <property type="entry name" value="PTHR37304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04070">
        <property type="entry name" value="DUF378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="67" mass="7125" checksum="0A883005640326A8" modified="2018-12-05" version="1">MKALNLISLVLIILGGLNWLSVGLFEYDVVSELFGGSDEVGSKIVYTIIGVAALYAISLLPRAAKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF08</accession>
    <name>A0A398CF08_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01776">
        <property type="protein sequence ID" value="RIE01776"/>
        <property type="gene ID" value="D3H35_13320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="348" mass="38460" checksum="58FE32C299D3788C" modified="2018-12-05" version="1">MEIGIYTLADLCRNPHTGETVSARQRLHEIIEIAKLADEAGLDVIGVGEHHRLEYAVSSPAVVLAAIAQVTKRIKLTSATTVLNTVDPVRLFEDFASLDLLSDGRAEIIAGRGAFIESFPLFGYDVNEYDELFEEHLELLLKLNASEKVSWSGRHRPALHEADIAPRPVQDEIPLWVGVGGTAESAERAGRFGTNLALAILGGDPLRFKPFVELYRQAADQAGHARETMKVGVTGHTFIADTTEQARDEYYPYYVNYWEEVNRQRGVSSQLSRADYDRMSAPDTALFVGSSQQIVEKILRQHELFGHQRFIAQLDIGGLPFGKVADNIERLAVEVAPAVRRATGNANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF17</accession>
    <name>A0A398CF17_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000055">
        <property type="protein sequence ID" value="RIE00482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00482">
        <property type="protein sequence ID" value="RIE00482"/>
        <property type="gene ID" value="D3H35_28285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="262" mass="29742" checksum="5733271F797224B0" modified="2018-12-05" version="1">MPTDYPRPAVQSFKGDQIQFVLDGELSAGLNRIAAETGTTLYMVLLAGYNVLLSKYTGQEDIVVGTPIAGRPHADVENIIGMFVNTLAMRSRPAGEKTFTAYLQEVKEVALQAYEHQEYPFEELVEKLNVRRDLSRNPIFDTMFSLQNMSEEETEIEEMRFSPYGFEHSASKFDMSLTAVETGREIGLSLSYCTAIYTKETAERLGRHYVALLRDISSQTEKQLKAIELLSAEEKRQLLHAFNDTKVSYPRIKRFTGCLKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFF8</accession>
    <name>A0A398CFF8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Dihydroorotate dehydrogenase (quinone)</fullName>
            <ecNumber evidence="15">1.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DHOdehase</fullName>
            <shortName evidence="15">DHOD</shortName>
            <shortName evidence="15">DHODase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">pyrD</name>
        <name evidence="17" type="ORF">D3H35_27080</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.</text>
    </comment>
    <comment type="function">
        <text evidence="3 15">Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-dihydroorotate + NAD(+) = H(+) + NADH + orotate</text>
            <dbReference type="Rhea" id="RHEA:13513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>(S)-dihydroorotate + a quinone = a quinol + orotate</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="15">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 15">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterotetramer of 2 PyrK and 2 PyrD type B subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 15">Cell membrane</location>
            <topology evidence="5 15">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 15">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="15"/>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00632">
        <property type="protein sequence ID" value="RIE00632"/>
        <property type="gene ID" value="D3H35_27080"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004589">
        <property type="term" value="F:orotate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00225">
        <property type="entry name" value="DHO_dh_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 15" id="KW-0288">FMN</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 15 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 15" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="16">
        <location>
            <begin position="55"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="121"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="258"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="15">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="72"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="329"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00011669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RIE00632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="369" mass="39573" checksum="E9FADED080982627" modified="2018-12-05" version="1">MSYSLLYKIAKPFLFRMDPEAAHHLIIDGMGGAAKVPGIKPLLSAAWGVKATPDLEVDLFGLHFSHPIGLAAGLDKNAKAVAGLSSTGLSFLEVGTVTPKGQQGNEQPRLFRLPPDEALINRMGFNNEGADAMADRLGKLGRRRIPLAVNIGKNKATPNENAADDYRACLQKLYPHGDFFVVNISSPNTPDLRALQHGDELRTLLDAVNDEMEKQAQRHGGLPKPILVKIAPDNTDEQLAYMADAIVQSGMSGIIATNTTIGRDGLTHGNKAETGGLSGRPLTNRSTEVIRAVYSLTKGKLPIIGSGGIFTADDAYDKIRAGASLVEVYTALIYKGPGVVKEIHTGLRERLKRDGFSRITQAVGADHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFH1</accession>
    <name>A0A398CFH1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01165">
        <property type="protein sequence ID" value="RIE01165"/>
        <property type="gene ID" value="D3H35_22440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="60" mass="6594" checksum="388D0C375AE943CE" modified="2018-12-05" version="1">MGLLYNYCQSIQNNKDHGIEREHLGPSGETEPSLSLLALMSRPIGSDKMVSDYDAPAKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGH6</accession>
    <name>A0A398CGH6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable DNA-directed RNA polymerase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RNAP delta factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpoE</name>
        <name evidence="9" type="ORF">D3H35_21675</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">RNAP is composed of a core of 2 alpha, a beta and a beta' subunits. The core is associated with a delta subunit and one of several sigma factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RpoE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01052">
        <property type="protein sequence ID" value="RIE01052"/>
        <property type="gene ID" value="D3H35_21675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00357">
        <property type="entry name" value="RNApol_bact_RpoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007759">
        <property type="entry name" value="Asxl_HARE-HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038087">
        <property type="entry name" value="RNAP_delta_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029757">
        <property type="entry name" value="RpoE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05066">
        <property type="entry name" value="HARE-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04567">
        <property type="entry name" value="RNAP_delt_lowGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51913">
        <property type="entry name" value="HTH_HARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH HARE-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="119"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="195" mass="22543" checksum="2D8EACE53CCC1BEF" modified="2018-12-05" version="1">MSAEYVLKLDSEKIREMPMVDLAFEVLKAANTPFYYRDLMTEIAKHRGFSEEAVNEVIAQVYTEINIDGRFACVGSNVWGLKRWYPVERSEDPVTGGAKRPRIINDDDDELDEDIYGEEEEETFTPDEENYDLFDEEREEIFDEGEETAEVDEEVAIEEEEEQSLDEDLGEGEADDEDDFDDEDDDSDADDEDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGR8</accession>
    <name>A0A398CGR8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4358 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01152">
        <property type="protein sequence ID" value="RIE01152"/>
        <property type="gene ID" value="D3H35_22355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025648">
        <property type="entry name" value="DUF4358"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14270">
        <property type="entry name" value="DUF4358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="120" mass="13974" checksum="1E196390BDE39E2E" modified="2018-12-05" version="1">MLEQVEQPRLIELESDKLKDIYYLDPELLTEFTIRMPLMNVKTNEIAVLKVKNAKDIAAVKKGLEKHAIDVQKQFETYLQDQYENAKNYKIVTKGNYVLFVISESADDLVKAFSDIFEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGT0</accession>
    <name>A0A398CGT0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_22430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01665">
        <property type="protein sequence ID" value="RIE01665"/>
        <property type="gene ID" value="D3H35_22430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031621">
        <property type="entry name" value="HisKA_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16927">
        <property type="entry name" value="HisKA_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="299"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="383"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="525" mass="59022" checksum="4B8EAB95EF1EBB5A" modified="2018-12-05" version="1">MDSQLTMYITLVSVSGVFNAFLSLYVFFRRSEIPGARTFIIYTIALSIYSFAYAFELASDTLWKVKLWTVIQYMGMPFAAPLGLMLILHYLGWKVSRKGAAALLVVPSITWLMVATNDYHHLFYKVIRLKENLPSPLLDIEIGEWYIVHGIYTFSCLLAAAALLLSRWKQTRKSYRLQLFTLICGQLIPMVTAFLYLVGATPAGIDPVPMVMCITSGLYIWAILSIKMLTVIPIAKETIFDSMGEGVIVLDSAERLIDYNRAVGRMIPSLRPAMLGRTLDQVWTELTGASFPFIRQPDGSAEELAWTSNGMERFYEVRSSVLRHRNGEQAGSLLMLINVTELKRLQQELEHQAFYDGLTQIFNRTQFIRRGREMLAESLRLGNPFTVMLFDIDFFKRVNDNFGHETGDKLIVHVVSTCRRLLSADMLFARYGGEEFVLALPSSPLLDGSSIAERLRAELEAHPLLTAGGEIAVTASFGVAQAEIGRDETLDTLLRKADEALYASKRNGRNRVSEYAAQGPTPAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGY2</accession>
    <name>A0A398CGY2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01222">
        <property type="protein sequence ID" value="RIE01222"/>
        <property type="gene ID" value="D3H35_22770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="92" mass="10138" checksum="6A02D5D723D942D1" modified="2018-12-05" version="1">MQESVGERGVAARMGGDEFILIIRRSPSAQDIQELIRYIQDEFARYTARCGTLHVGISIGASYYPADGTDGQALINVADNAMFEMKRSQAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHD3</accession>
    <name>A0A398CHD3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zn_ribbon_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01890">
        <property type="protein sequence ID" value="RIE01890"/>
        <property type="gene ID" value="D3H35_14005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025868">
        <property type="entry name" value="Zn_ribbon_dom_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12674">
        <property type="entry name" value="Zn_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_ribbon_2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="90" mass="10086" checksum="C047BABBF527C52F" modified="2018-12-05" version="1">MGQVYKNCQSCGMPLKRDEKGGGTEADGTKSAKYCSHCYEGGRFTLPDLTVAQMQERVRAKVIEFGMPKFMAGFFTRGIPKLERWSKPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHG9</accession>
    <name>A0A398CHG9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">M6 family metalloprotease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_24000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01432">
        <property type="protein sequence ID" value="RIE01432"/>
        <property type="gene ID" value="D3H35_24000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005085">
        <property type="entry name" value="CBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03423">
        <property type="entry name" value="CBM_25"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05547">
        <property type="entry name" value="Peptidase_M6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01066">
        <property type="entry name" value="CBM_25"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017258006" evidence="1">
        <location>
            <begin position="29"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="532"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="714"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="900"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1086"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1265" mass="136053" checksum="F0A5A65483E91CB2" modified="2018-12-05" version="1">MRKSHYRSYCMVVFLFLAGLCIGGLASASPARPDLQPFTQPSGQTFQARLQGDENLNWAVTTQDEIIVKDEDKYWNYAELNNGNLESSGEKYGVDPRPTEVVNSEELNEFFEENPEVLESSNAARSGGLLENSGPAAPANGGLFENIAGQETKGTQKILVLLVEFTNINFIYSDSQWNNRFFDTSSRSVRDYYREVSHGQLDFVPATETKGTANDGIVRVQLNHPHETGGNIAKEAIIAADPYINIASYDTDGDGYIQNDELRIVTILAGYETSYSSAYTPTVWGHFSGLGSSDAPTIDGKKVFDSNHGGNYTQQGERHGDHMATIGILVHELGHSLGVPDLYDTDSSSSGIGIHSVMSYGSWGALSGEYAGTTPVHFDAWSKTMLEYVTPTLAKTNTSTAYTLKSISTNAYNVVKIPTSDPKQYFLLENRQYEGYDRSLNMHGGIAIWHIDQNQSGNYDDLRRLVDLEEVSEYNPYFYSGNATDFTPNTVPNSNRYTGYYIDQYTGINVNVPQTSSNSMTVNVYGDYTATAPTSLSSTYSTMSTVGLTWNATTDTDFDHYVIYRNGNLYTTTTKTSYKDAWLNGSTTYTYTVRMIDKAGNESVDSNAVTVTTAATDSVIIYYKQGFSTPYVKYKIYYSDPWMDLALVPSEFPGYSKAVIPKGIELSSIAAYFHDGNGNVDDNSGRLYSFAPGVSTFVSGLITEDYPDTQSPSVPTGLVSTDKSDTQVSLKWSAASDNLGVTGYEVYRDNVKIGTTSSLSYTATGLTGSTAYSFTVKAYDAAGNLSGASAPLLITTNPSHIVTIYYKPGFNAPNIHYRPAGGTWTAVPGLPMAVSEVPGYYKFSINIGTASQLEACFNNGSGTWDNNNGSNYIFQLGVWTFYNGTITSGAPTPDTQAPTVPTGLASTAKTDSSVSLAWTASTDNVAVTGYDIYRDGTKIGTSTGTSYTATGLSANTSYSFTVKAYDAAGNISAASVALSVTTNPITGNTVTVYYKKGFSTPYIHYRPAGGTWTTVPGVAIPASEATGYNKITINIGSATQLEACFNNGSGTWDNNNGANYFFGVGTWTFNAGTIVSGAPDSQAPSTPAGLASTAKTDTSVSLTWTASTDNVAVTGYEIYRNGTKIGTSTSTSYTATGLSANTAYSFTVKAYDAAGNVSAASSALSVTTNPWTGNTVTIYYKKGFNTPYIHYRQANNTWTSEPGVAMSASEVSGYNKITINIGSLTQLEACFNDGNGNWDSQYGANYFFGVGTWTFNAGSITAGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHM8</accession>
    <name>A0A398CHM8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoyl synthase</fullName>
            <ecNumber evidence="6">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lip-syn</fullName>
            <shortName evidence="6">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">lipA</name>
        <name evidence="8" type="ORF">D3H35_19000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein].</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02736">
        <property type="protein sequence ID" value="RIE02736"/>
        <property type="gene ID" value="D3H35_19000"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00116"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="51"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="297" mass="32992" checksum="02F291F51216ADA4" modified="2018-12-05" version="1">MGTRTKEPKPDWLRIKLTTGDSYKEIKDMMRTKTLHTVCEEARCPNIYECWANRTATFMILGDICTRACRFCAVKTGLPTELDLQEPERVAEAAEQMGLRHCVVTSVARDDLKDGGASIFAATIHAIRARMPLCSVEVLIPDFLGDEASLRIVMDAKPDILNHNIETVERLSDRVRAKAKYSRSLELLRRAKEMQPQIPTKSSIMLGVGETIEEVHQAMDDLRAVDVDILTLGQYLQPSSTHLNVERYVHPDEFAELKIVGKSKGFSSVESAPLVRSSYHAHEQVKTAAAAAAGAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHQ4</accession>
    <name>A0A398CHQ4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidored_molyb domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_14460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01970">
        <property type="protein sequence ID" value="RIE01970"/>
        <property type="gene ID" value="D3H35_14460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_molyb" evidence="2">
        <location>
            <begin position="42"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="197" mass="22403" checksum="D030BA5DA7F99F6C" modified="2018-12-05" version="1">MNDTSSGGNRMLPEPEPLPDSVRVIGGGAEGRFRVYTVTRLPSFDSQTWTFTLDGLVDRPAVWSWERFLAIARKVQVSDFHCVTGWSVYRNTWEGIPLSELLKLAGVNPKAKYVKFYSGDGEYTDALSLEQANMDDVMVAILHDGKPIHRDYGGPARLIVPKMYAYKSVKWLNRIELVDKPHTGYWEERGYDNDAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI77</accession>
    <name>A0A398CI77_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_27745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00538">
        <property type="protein sequence ID" value="RIE00538"/>
        <property type="gene ID" value="D3H35_27745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="217"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="308" mass="33029" checksum="8AC24FADCD7A7E74" modified="2018-12-05" version="1">MKMEQRYASAERSALVSLLGLLGLTVAKGAAGWLTGSKALLADACHSAADCAGSLTSFMGIRNSKQSEAKKQTESAIAIVLSAFLLVAGIEIGVSSVRSMAAGADQPPEWGSVIVIVAGIGAREALARYKRSKDIQLGIRAERSGESRSDIFASITALVGTTGAIAGDLLDIPILYVMDPAAGIVIAAFVLRMGYQLITTVLQSTGRSALNEIDAQTLLESMQRIDGVVAVEELRAREQGHYLVLDVVIRVNPRISVTEGQEIALRVKRHLTKRFLHICDACVQVQPYDPGFPYKSNHHEEELPSFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI80</accession>
    <name>A0A398CI80_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF115 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02065">
        <property type="protein sequence ID" value="RIE02065"/>
        <property type="gene ID" value="D3H35_14980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002826">
        <property type="entry name" value="MptE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01973">
        <property type="entry name" value="MAF_flag10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAF_flag10" evidence="1">
        <location>
            <begin position="207"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="667" mass="75620" checksum="04FC01694C00CA2D" modified="2018-12-05" version="1">MTTYSSNIQFLTDYNQWLIDMMEHVDYGHIEAGYVGDEVVFKLADEQGNEFYTASAYNPQYEAEQFLDGVNFDNTGYILMGMGSSAIVKKILENKTEAAWVLIIEKDTALVKKFLEEVDLSPYLQGKLQRIIILTELMGDISVVLNTYISSMIGYYFLQTEVLRTFASYRRDSQFYVEMTESLINHLRTHMTAMGNSLEDTLMGMTNELKNVPISLKSNRLTELKDKYQGKPAILVASGPSLDKQIPLLKAVKGKALIICAESAFRVLLKNDISPDIVCILERGTNSYDLSVKGVEIPEDTALMGLTLMDARIPRHWNSFVVPVFKENIVHSHQMNQALGNLGALYNGNSVAHLNYSLAQYLGCSPIVFIGQDLAYSDDGVTHSKHSFYVDESDEDISVAQRKQIQSSLQEDKDFFNRTVYLDGYYGGKVKSRELWRQFLHWMEHLVRVMPASLVINATEGGADIPGTVKMPFAEVVEQYCNDPIVTIPELFSQLSPIPADDEIKESFAGMVDFFNEHLGVMEGIIQFADEVLDSLKQLQGELADNPDGNIQLLDMKAGRVLRNVERLLKDILGDPLSNFFFRPLVSNYHVKMNPISRVSSIDRLQVILKNQSFLLTRIIAGKKQVFEVYEKGIRESARELGYDDDEFMLNTKTKWEIPDWELEEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIC0</accession>
    <name>A0A398CIC0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_20745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03026">
        <property type="protein sequence ID" value="RIE03026"/>
        <property type="gene ID" value="D3H35_20745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="313"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="585" mass="66880" checksum="50AAE4C2F77B3073" modified="2018-12-05" version="1">MRKLNDMKLRNKMVMSCFLFFILPFMIVGFFVVQQYRQSALDKAIEQSENTIERIKNRTSEVLNVSIGLSNRMTIDNDLKKIANAHYLNTIDVVDAYRDYDKFKVYLDFNPEVSKINLYVDNPTLLNNWEFYPLNAETKSAFWYESALKNAGLIGWYYYPTDSRHNANMLSLVRSIYFPETRTFGMLTIDVNTGYLNSILRQEDSEIVLADENGVIVSSNRPSMVGKKLDDTHFGYGMSRQEAGTREMVIEGRKSQVRIDRLSPEKSYNSLMIVTVSAIDEMVREANRISTVGLEIIGIAGILALLLIYFICTVMTNRLLKFSKQISKVSMGNFNTELTVDGNDEIGQISRQFNQMVGNVKELMEEVSRSHQETSELERKQSEIKLKMLASQINPHFLYNALESIRMKAHLRGEKEISQTVKTLGKLMRKNLELKGQPISLKEEIDIVRCYLEIQKFRHDERLDYKLDIAPEAENVSILPLLIQPIVENSVIHGLEKNVEGGKVTVTARLSQGGLRVTVEDDGIGISRPKLNAVQQSLKEQDADRIGLHNVQQRLLLTYGELSGLRIESEKQTGTKITFWIPVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CID5</accession>
    <name>A0A398CID5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_17590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02503">
        <property type="protein sequence ID" value="RIE02503"/>
        <property type="gene ID" value="D3H35_17590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="213"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="423" mass="47980" checksum="1661528F1D8BAED2" modified="2018-12-05" version="1">MSITIRTSDRLSDTRTYFDYASIVKKITELLESKYGCAFRLYFQEDSSEVWDALDEDIRSGFPELEHAASVYDLVETRMFSYECDPEPEKTGYDIRHSVSNNVFVYSKHKVAFVRVPREVQYGLNFENLIFAAGDECMGAFLADMQARQLQNRKILVFTDTRDGLDRSRETTVQPVTRDDVIMDETLKTQLYRSVDEFFSKDRSFFQTYGVPYKRGILLYGKPGNGKTTLVKSISATVGAPVAYWQITEFTNSESIQQVFAAALKLAPMVLVIEDIDSMPASCRSFFLNTLDGATSKEGLFLIGTTNYPDKIDPALMNRAGRFDRAYEVKLPDEALRLAYLTRKGMNRLVETDAVAVAARRTEGFTFAQLSELYVSAALQFHYESALNLEELISGMKADFSKGRSREWMTEGRSRSLGFVPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJC3</accession>
    <name>A0A398CJC3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_25510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00928">
        <property type="protein sequence ID" value="RIE00928"/>
        <property type="gene ID" value="D3H35_25510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="187" mass="20702" checksum="836EE993AA2D83FF" modified="2018-12-05" version="1">MFQTLYFAPVVLSTVALVQIFQNVFSVNPVGMLNYFLSWFQPSMLDSEWLSDPHRSLLIVAIAEGYKFAAVYMVIFYSALISISEEVIEAARMDGASGWKLYRYIKLPMIKGIIFTSIILVLNGSLKSFDIPYLLTYGGPALPANWSPPICISKRSAACITGMAARLPCSSPLSVFSWSDSLCKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJE7</accession>
    <name>A0A398CJE7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_25700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00958">
        <property type="protein sequence ID" value="RIE00958"/>
        <property type="gene ID" value="D3H35_25700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017188134" evidence="1">
        <location>
            <begin position="26"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="334"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="395"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="462"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="522" mass="54541" checksum="83CD28613CA7365D" modified="2018-12-05" version="1">MTKKVLAFLLTIGVIASLLAPAAFATGPAITASAQIDNKTREVKISGQISSGAGQQVTVKVQGPQNEQLYVNQTTSLANGSYQFVYTLSSTAREGQYGVVVGGSGISKEEQAVTSFTYTAGTTTPPVSSGGGGGTTPEPGVVNLTKDDLKGNPSAGKVSITIPQGTIGGSNGSAKVVLPANTADIIGDNSLELKSDKLTIVIPHSVLVILQGAVPADVQATSEISLTVSTLPKQQSDSLLEKAASGDKSGLNAAGSVYEFKLTVKMPNGEEKTITSFEEPLEIAFAIDADADQALLGVYFIANDGTLEYIGGKIQNGQMLAKISHFSIYAVLEYKKSFTDVTAGFWAARDIQVMAAKHIVYGKTESTFDPKGQVTRAEFAAFLVRALELKASGVAKSPFADVASDKWYAGAVAAAYEAKLISGKDAAHFKPEGLITREEMAVMIARALEKQAKATTVADGLLNKFGDRGNVSKWALEAMQISLQANILLGNADSKLLPAANASRAESAAVIRRMLDYAGSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJQ8</accession>
    <name>A0A398CJQ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Esterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02372">
        <property type="protein sequence ID" value="RIE02372"/>
        <property type="gene ID" value="D3H35_16795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="463" mass="52104" checksum="EF0128517492625E" modified="2018-12-05" version="1">MWTNSTIETIHNFHARKLNNERRLFVYLPPGYEGGEQRHYPVLYMHAGQRAFDPAKPGTESWNIHKAADRLIAEGLMDGIIIVAIAHVRPVTANEYYHFTGPKDEIEHISCSGLDYEDFILNDVKPYIDSRYRTLQGPENTGLIGSSAAGLCTYHIGFRNPDVFGKLIMLSPYFVKARLGKKEEFELHEELIFEPYGGHPPLRVWMDIGDAEGLFLPSHVKDAVDILLQNGFRYGDDIAYLEQPEAAHQETDWGARVHIPLLFMFGNTGKATSLELRGRDVVGLQGMTVRINPIVHFDSGFAMSELNGTYAVEDPEVLEVKPDGTIVPKKEGSTTVTLTSNGIQASKRYEVVSALSEGVEVRMSVEVPEDTPDDSTIYGGMGMELLSVGSNRYEGRFLVPRDSGFNFRFTRGFRKFELDAEGNGIANRSFRASENTTLHCKVERWEGVHREEPERRSHASLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJV6</accession>
    <name>A0A398CJV6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000035">
        <property type="protein sequence ID" value="RIE03596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03596">
        <property type="protein sequence ID" value="RIE03596"/>
        <property type="gene ID" value="D3H35_10680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="391" mass="44406" checksum="7D94E609334611BC" modified="2018-12-05" version="1">MLMWDKPEVVEGLTVYRDHEDRTLYYVLPSVPGFRIDDNGLPVFKFIKYRFPIDRPDGKKGGGFLIADVEFSVPEDKLAKVKEALQERLDEQARNLGQQTPASPVKFGQLSFLRGTASITVLDDGGSLVEKVINPAAPSLYGKMITPFTAELSAEGATLLEQALQGKGAIVQVAYDLWMPVRLPPVKARIWFKAEKFMEFHQEIDVEENFWSEDDYREKISEKFSQREAGGVQIDPGGVVDQKVIGAVRDWALRNWEDRLAKMVLGDIPPVDRDASKWYTEHDFENISRDVISSRVSSFDIKYEEGSIMEWNPSPRGSLPNITTLTGRDGQPFKWEDFSLTVDLDDPFFRQLRVTTRANADFDKLPLNSVEVKIEYKQGRAQHQGIRSSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK35</accession>
    <name>A0A398CK35_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heptaprenylglyceryl phosphate synthase</fullName>
            <shortName evidence="9">HepGP synthase</shortName>
            <ecNumber evidence="9">2.5.1.n9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycerol-1-phosphate heptaprenyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pcrB</name>
        <name evidence="10" type="ORF">D3H35_29895</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate = 3-heptaprenyl-sn-glycero-1-phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33495"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:58206"/>
            <dbReference type="ChEBI" id="CHEBI:64781"/>
            <dbReference type="EC" id="2.5.1.n9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GGGP/HepGP synthase family. Group I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.n9" evidence="9"/>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00247">
        <property type="protein sequence ID" value="RIE00247"/>
        <property type="gene ID" value="D3H35_29895"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002094">
        <property type="term" value="F:polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02812">
        <property type="entry name" value="PcrB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00112">
        <property type="entry name" value="GGGP_HepGP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039074">
        <property type="entry name" value="GGGP/HepGP_synthase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038597">
        <property type="entry name" value="GGGP/HepGP_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008205">
        <property type="entry name" value="GGGP_HepGP_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40029">
        <property type="entry name" value="PTHR40029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01884">
        <property type="entry name" value="PcrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01768">
        <property type="entry name" value="GGGP-family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Glycerol-1-phosphate binding" evidence="9">
        <location>
            <begin position="161"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glycerol-1-phosphate binding" evidence="9">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>sn-glycerol 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>sn-glycerol 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE00247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="230" mass="25364" checksum="78C1DEDD4ADE286E" modified="2018-12-05" version="1">MIPSFYKHWRHVFKLDPDREIDDASLDRICMSGTDAILVGGSSGVTYENTVDLLARIRRYEVDCAFELSDPACGVPGFDGYFVPMVLNTPLREWMIGHHVNALKDFGHLLPWESVVGQAYLVLNPDSTVARVTEAETDIDSDTALAYSHVADRLLNVPVLYIEYSGTFGDMELVRKIRGGLRQAHLFYGGGIDDPDKARLAAQTADTVVVGNVVYRDLEAALATVSAVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK87</accession>
    <name>A0A398CK87_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02562">
        <property type="protein sequence ID" value="RIE02562"/>
        <property type="gene ID" value="D3H35_17905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="202" mass="22562" checksum="682F866EC93A77BC" modified="2018-12-05" version="1">MGYYGETTTDPKGNVTAKVYDKTGRLYQVKDGSTVQSTYVYYADGSQNTVTYANGSKEEYVYFKDKTLKTLKNYQGATLLDTYDYTYDAAGNQLKKTEKVNGANKGDTNYQYDDLNRLKKVTEPGGKVTDYTFDAFGNRSSEKTTQGAAVTVLNYSYGALPNSLLALFLMRGPLSTSLVILQQLMLQLLAARHFQKSKKIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKB1</accession>
    <name>A0A398CKB1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02795">
        <property type="protein sequence ID" value="RIE02795"/>
        <property type="gene ID" value="D3H35_19360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="60" mass="6616" checksum="195E42B3FD471237" modified="2018-12-05" version="1">MDELTGIPKPCSYGILFGESNKAKTVMVRGNVLIARFIRAWGESQAFGLRRVDSIPESDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKH1</accession>
    <name>A0A398CKH1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YqzE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_28640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00387">
        <property type="protein sequence ID" value="RIE00387"/>
        <property type="gene ID" value="D3H35_28640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025622">
        <property type="entry name" value="YqzE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14038">
        <property type="entry name" value="YqzE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="75" mass="8960" checksum="B4CFBA61D0DE9B9B" modified="2018-12-05" version="1">MSDGSDLLKYVTQRVVTYMDTPAEGQSRKERRKRKEPWATRWFGQLLPLGISLWWNGRKRNKPYPPARLVERELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKI6</accession>
    <name>A0A398CKI6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ger(X)C family spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_19440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKC lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02810">
        <property type="protein sequence ID" value="RIE02810"/>
        <property type="gene ID" value="D3H35_19440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008844">
        <property type="entry name" value="Spore_GerAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038501">
        <property type="entry name" value="Spore_GerAC_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35789">
        <property type="entry name" value="PTHR35789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05504">
        <property type="entry name" value="Spore_GerAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02887">
        <property type="entry name" value="spore_ger_x_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017328410" evidence="4">
        <location>
            <begin position="21"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="414" mass="45406" checksum="273D15FCE311A0E6" modified="2018-12-05" version="1">MKPGKRLFKLAMAVLATAFAAASLSGCWNSRELNKLAIVTALAIDRAPDSDKYKLAFQVVMPGELSRTSGSGGGNSTPVSIYEIEASTLFEGIRRASKQVPRQLFFSHVQVVVLGERLAKDGIEEIFDFFERSHEVRLTSMLLIARDGSPLNLISSLVPMEKLQANALQGASTLSSQIWSESTVVEIDDVIRKLINPGAEPTIGGLKLIGDDKAATNKKSLEQTVPSHRIELSGIAMFKEGKLAGWLDDGFAKGFLFATDRVRSTVMNLNCEGKREGIALEVVRSKASSKVTMKKGKVKVDISVTAEGNVGEVKCGISLDKLSVLRKLEKDWSEAAKVDILGAVYTAQQYKADIFGFGEFLERYHPKEWRKVKDEWGEAFAKADVNVSFRAVIRRTGMRGKSLLEKTKEGEISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL24</accession>
    <name>A0A398CL24_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein HflK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hflK</name>
        <name evidence="8" type="ORF">D3H35_19950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">HflC and HflK could encode or regulate a protease.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">HflC and HflK may interact to form a multimeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the band 7/mec-2 family. HflK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02892">
        <property type="protein sequence ID" value="RIE02892"/>
        <property type="gene ID" value="D3H35_19950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03404">
        <property type="entry name" value="SPFH_HflK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010201">
        <property type="entry name" value="HflK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF2">
        <property type="entry name" value="PTHR43327:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01933">
        <property type="entry name" value="hflK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="7">
        <location>
            <begin position="39"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="345" mass="38124" checksum="B5F36024B8595021" modified="2018-12-05" version="1">MEVIHSDGKRRNVNEIPPGLFRKIGIGIGVVILLMIGYSSFYTVQEQERAAILTFGKYTDEATAGLHFKWPYPIQQVIKVPAELTQRINIGYRQVGDQITPVEEEAMMITGDENIVSADAVVQWKISSIRDYLYNVDDPERFLRNAASASIRSVIGSEKLDYAITDGKTAIQDKVREKLLELQTKYKTGIQIVDIKFQDIEPPSGQVEDAFREVTNAREEKNTKINNANKYENDRIPKARGEAQALIEKATAEQKSRILNAQGDVAKFNAIFEQYKLNPDVTQSRLIIETLEKILPNAKIFISDSSGGDTVKYLPINELLQSGKGAAAPTASGSTGGASQGGTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL94</accession>
    <name>A0A398CL94_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000051">
        <property type="protein sequence ID" value="RIE00617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00617">
        <property type="protein sequence ID" value="RIE00617"/>
        <property type="gene ID" value="D3H35_27545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="109" mass="10989" checksum="4E148107C2748866" modified="2018-12-05" version="1">MGARLLQGNLLRQWFEPTLTPGQVTAASFSPNLSTAYSSAATSCGRATPAPRAEFTGSTTAKPESKSPTEGTGNGDAAGGHNPPTPESPPAASTSPTEGTGFPIASDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLK5</accession>
    <name>A0A398CLK5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dnaG</name>
        <name evidence="16" type="ORF">D3H35_06245</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13 14">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the DnaG primase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04216">
        <property type="protein sequence ID" value="RIE04216"/>
        <property type="gene ID" value="D3H35_06245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002811">
        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="15">
        <location>
            <begin position="263"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12 14">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002811-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RIE04216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="608" mass="68588" checksum="B49FFC436408A9E2" modified="2018-12-05" version="1">MNEGKIPQAVIDEVLRKHDIADTVGKYVHLSKNGKYLKGLCPFHSEKTPSFTVTPEKQIFHCYGCGKGGNAIKFVMEMEGETFPEAVKRMAEEAGIAVTWSDSSGAEPSPRQREKQTLFEAHAYTAKLYHYLLQNTEAAKSAKDYLRSRGFSDKLIEEFGIGYAPARWDTLVQALARQQYEPAEMERGGLLSRKQDGDGYVDRFRDRVMFPIHDGDGRIVAFAGRLMTDGQPKYLNSPETPLFNKSRTLYRLHEAKGSIRRTKQVVLFEGYVDCIKAWWAGVHNGVATMGTALTAEHAALLRRYADEAIICYDGDDAGQAAAQKSIPLLEAAGLRARVGIMPNRMDPDEYVSSYGGEAFVRECIDGAVSAVKFQLIYLRKSHILLEDDGKIRYLSEAVRLVARRESPTERELLLKELAQEFNVSVDTLKQEVVDVRRQEKLGNAGDIPTGSWNNVWNEKKTASKHPELGAAYVSAERQMLSWMMQDAEVAFTVQQRLGPDFLVDDHAAIAAYLYAYYAEGNDPNAGRFIAYLNDDRLERLTSFIALSEVPFGEKELDDFFKTFERTSLEREIKRKYEELHSAQRTGDHLLAAKFGIEIIALERKRKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLK7</accession>
    <name>A0A398CLK7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LD-carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_10870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S66 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03543">
        <property type="protein sequence ID" value="RIE03543"/>
        <property type="gene ID" value="D3H35_10870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040449">
        <property type="entry name" value="Peptidase_S66_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="PTHR30237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02016">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028757">
        <property type="entry name" value="LD-carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="SSF141986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S66" evidence="4">
        <location>
            <begin position="14"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S66C" evidence="5">
        <location>
            <begin position="178"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR028757-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="311" mass="33023" checksum="66AE7F90582C19A7" modified="2018-12-05" version="1">MATKPLALQRGDVIGIVTLGSPLEAAVIDARIDVLRRTGLGVVLGRHVYDATGFLAGPAAGRAEDLMTMFADPRVKMILPTRGGVGVEGILPYLDFAYIANHPKIVSGYSDITALLNALYQQADLISLHSLLLIDFKSETPAYNFEQFFTATSSIEAPRPILNPPGKPMTGKVPGIATGPIVGGNLTSFVGMLGTPFEIDTRGKIVLIEETHEPVNTVYRYLEQLRLAGKLNDCSGILIGECTGCVEAYGVTYEELIDNYLVPLGKPLISNLASGHGVYKAAIPIGANAVMDGAEGTIALLEPAVRYPGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLP2</accession>
    <name>A0A398CLP2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_15395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02139">
        <property type="protein sequence ID" value="RIE02139"/>
        <property type="gene ID" value="D3H35_15395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016701">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LigB" evidence="5">
        <location>
            <begin position="23"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="257" mass="29001" checksum="D4078BB27D3E03B1" modified="2018-12-05" version="1">MMPSYFFAHGAPSLVLDVHEYTSFLKSFAASMPTKPKAIVLFSAHWEHPTQQVSAVPSYSTIYDFSGFQDELYRMTYPAQGNLALSDEIRTLFEQHGIPSASDGQRGLDHGAWAVLKLVFPEADIPVVALSVNRHLTNEQQYKIGQALGALREKDVLIIGSGGTVHNLRRVNWRAESAEAWAVAFDHWLREKLEAWDTESLFRYRELAPYAQEAVPTTEHFIPLLLAMGSGDENKRAKPLHRSYQYGTLSLSSWQFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM80</accession>
    <name>A0A398CM80_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_26525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00751">
        <property type="protein sequence ID" value="RIE00751"/>
        <property type="gene ID" value="D3H35_26525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="19"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="260" mass="29671" checksum="6409DD8F329F9FA3" modified="2018-12-05" version="1">MTLLSNAAAEQAVCHREIICLDQLSFAFGPQQVLSDLSFTIRERDFVGLIGSNGAGKTTLLRTIVGLLKPTSGKVSLFGTAAERFKDWQWIGYVPQRNHFNPLFPATVREVVLSGLYGRRKLFKRISRSDITRSEDALRTLHIEDLADKRIGALSGGQQQRVFLARALINNPKLLILDEPLTGIDTETQQNFFHLIRHMHQKHNITFLMVSHDMDMVRSYLGEEPKMRYGKLGFYVRHSHDLEDCVETDLLHTLRKEGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMH1</accession>
    <name>A0A398CMH1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage V sporulation protein AC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spoVAC</name>
        <name evidence="2" type="ORF">D3H35_21945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01087">
        <property type="protein sequence ID" value="RIE01087"/>
        <property type="gene ID" value="D3H35_21945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014203">
        <property type="entry name" value="Spore_V_AC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005562">
        <property type="entry name" value="SpoVA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38450">
        <property type="entry name" value="PTHR38450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03862">
        <property type="entry name" value="SpoVAC_SpoVAEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02838">
        <property type="entry name" value="spore_V_AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="154" mass="16269" checksum="1174F7496342E8EC" modified="2018-12-05" version="1">MANKKTKKLTPVQQQYQQAALRRIPPRPFVKNGLRAFLVGGTICLAGQGIQQALIHYGGMNKQQAASPTVAILIIVSVILTSLGVYDKLGQWAGAGSAVPVTGFANSMASAAIEHRSEGLVLGSATNMFKLAGSVIVFGTVAAFVIAFIRLIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMT0</accession>
    <name>A0A398CMT0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_09485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyltransferase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03775">
        <property type="protein sequence ID" value="RIE03775"/>
        <property type="gene ID" value="D3H35_09485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="18"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="330" mass="37417" checksum="3C3B4193FDCD19E8" modified="2018-12-05" version="1">MKRLRSVLASPSRFEAQLYGYLIRRFCRIYIPYILAFGIGLFLLTSAPKFTSASLADIINNMWTQDLSTSDVLNHVYGIVSFDSRLVNGVIWTLVHEMRISIVFPFVVLLLMNLRWYYSIVAAVILSAVEALNFVFHFQKPIEGLDISYFDSLHFLSFFIFGMVLAKHRHQLANKFSQLSRNKKIGLLLLGFVCYNYSVYPLRAMKELGIELPYQFIFGDYINAVGICIFITAALASRKIGSLLTGRLPIFLGNVSYSLYLYHLVIMLALIHHFLGKISLVSLLGITLVLSLLVAYLGYVLVEKPSIVLGKKLTQRIGKKEKRKPHSTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMZ8</accession>
    <name>A0A398CMZ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000060">
        <property type="protein sequence ID" value="RIE00294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00294">
        <property type="protein sequence ID" value="RIE00294"/>
        <property type="gene ID" value="D3H35_29310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="21"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="148" mass="16526" checksum="A270B1F736C00548" modified="2018-12-05" version="1" fragment="single">ERVEVKPLRKDSEVGAGLMKDGRHVSLTLTEEQTEKLLKQVNKAYNTEINDILLTALGLAIGEWNDSKQAAIELEGHGREEIGHEVDISRTVGWFTTQYPVILEMEQSRELSYQIKTVKEHLRRIPNKGIGYGLLKYGKAAAEGGHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNB1</accession>
    <name>A0A398CNB1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative N-acetylmannosamine-6-phosphate 2-epimerase</fullName>
            <ecNumber evidence="6">5.1.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ManNAc-6-P epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nanE</name>
        <name evidence="7" type="ORF">D3H35_08425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23932"/>
            <dbReference type="ChEBI" id="CHEBI:57599"/>
            <dbReference type="ChEBI" id="CHEBI:57666"/>
            <dbReference type="EC" id="5.1.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the NanE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.9" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03975">
        <property type="protein sequence ID" value="RIE03975"/>
        <property type="gene ID" value="D3H35_08425"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047465">
        <property type="term" value="F:N-acylglucosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009385">
        <property type="term" value="F:N-acylmannosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006051">
        <property type="term" value="P:N-acetylmannosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04729">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01235">
        <property type="entry name" value="ManNAc6P_epimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007260">
        <property type="entry name" value="NanE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36204">
        <property type="entry name" value="PTHR36204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04131">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="229" mass="25114" checksum="8E53A198008F8DF5" modified="2018-12-05" version="1">MDTARNVLEQIKRKLIVSCQALPDEPLHSPFIMGRMARAAYLGGASGIRANSVEDIREIKSKVDLPLIGIIKNNYPGSNVFITPTRHEVDELVREGVDIIAMDATDRIRPDGSTIEELFPLLRSAYPNQLFMADCSTYEEAVRAAELGFDCVGSTLSGYTEATKGRSLPDFELIGRLTARLKVPVIAEGGISTPEELKRLFELGIYSAVVGSAITRPLEITKKFAMVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNN0</accession>
    <name>A0A398CNN0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WIAG-tail domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02859">
        <property type="protein sequence ID" value="RIE02859"/>
        <property type="gene ID" value="D3H35_19725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="2126" mass="220280" checksum="88219211AD34B5FB" modified="2018-12-05" version="1">MHMIVQISNNGKERDMKRKNPQQRSGKRRPLYYVDNPNRLELNWLDDIKKSIPKPLAVHSAAPAVAAPQPTGKSTKISTKHEADDMVPELDFDQPVQGEFVSTPREADEIVAVAFAAGPEETRHSTDHPGAEIARETVLSDAVITPSSDSVERRNRLEDNRMPTGASPVVFTDDIAGEAITSDKLAPFAILAAHLAAGSVTASALADFAVTAIKLADGSITTSKIASESIIGEHLAKNAISGQKIRDRSITGEKLRDGSVSSEKLADKTISSDKLADGSILPKHLSLSSITSELIQDQSITSGKIKSGGVRSENVANESIVTSKLADGAVTSLKLRDNAVTTDKIARGAVESKHLAEGLVLADHVAVGIVQGKHLAPEAVSAEHLGEGAVGTRELADLSVEGSKLAYGTVQSDHLAEGAVRSEQLAANSVEARHILDQSVTTAKLADQSVMTMKLGDHAVTSSKIADQSVSADKLADEAVRNRHLARGGVTAEVLADNSVQSRHLSADAVNGRHVAARSIERNHLTDGLIGSKQVAFGVVGSDHIAKGAVGAAELADGSVLGSKLAPSSVNGGHLARGSVESGHLADDSVGFLSLQSDSVTDRAIAPGAVGERQLGARSIYSHHLTDHLITSLKLSPECVSTDKLGDQSVTAPKLANASVTASKLAAGAVEPLALSDRAVTGRSLGEGAVGSRHLLPQAVKTLHLGEGSVKGDVLAEQSVEERHLADEAVHSSKLAEDSVNAGHLQALAVESRHLADGAVGARHLQAGIFRAEHMVGDIVGAGHLQTKAVGEKHVQPEAIGSEHLKPEAVQAAHLRKGAIGFTHLDNSLYEMVKMAERRIDSELLEPSAVAGIHIRNASITEAKLANGAVTEAKLGEGSVTEAKLADGSITEAKLTEGSVTVKKLADGSITGAKLASGSVGGSKLDETLREQISFAVTPITTGRLVDDSVTEAKLADGAVSESKLVDGSVTGSKLAYGSVIGTKLASGSVGISKLDEALQERISYAVAPIATERLVDGSVTEEKLAEGSVTETKLADGSVTEAKLAEGAVTETKLDEALQERISYAAAPIATERLVDGSVTEEKLAEGSVTETKLADGLVTEAKLAGGSVSESKLAGGSVTEAKLAEGAVTETKLASGSVGVSKLDEVLQERFSYAVAPIATERLIDGSVTEEKLAEGSVTETKLADGLVTEAKLAEGAVTETKLASGSVGVSKLDEALQERVSYAVAPIASERLIDGSVTEEKLAEDSVTETKLAYGSVTEAKLAEGAVTETKLASGSVGISKLDEALQEQINYAVAPIATERLIDGSVTEEKLAEGSVTETKLADGSVTEAKLAEGSVTEAKLASGSVGILKLDEVLQERISYAVAPIATERLIDGSVTEEKLAEGSVTETKLADGSVTEAKLAEGSVTEAKLASGSVGILKLDEALQERVSYAVAPIASERLIDGSVTEEKLAEDSVTETKLAYGSVTEAKLAEGAVTETKLASGSVGISKLDEALQEQINYAVAPIATERLIDGSVTEEKLAEGSVTETKLADGSVTEAKLAEGSVTEAKLASGSVGILKLDEALKERISYAVAPIATERLINGSVTEEKLAEGSVTETKLADGSVTEAKLVEGSVTEAKLASGSVGISKLDEALQVRISYAMAPITTERLADDSVTEAKLAEGSVKEAKLADSSVTEAKLAEGSVTESKLASGSVGISKLDEALQEQINYAVAPITTERLANNSVTEEKLAEGSVTETKLADSSVTEAKLAEGSVTESKLASGSVGISKLDEALQEQINCAVAPITTERLTDDSVTEAKLAEGSVKEAKLADSSVTEAKLAEGSVTESKLASGSVGISKLDEALQERISYAEAPIATERIVDDSVTEAKLTESSVTEAKLAEGAVTAAKLAEGSVTGDKLASESVGVRQLADRSITGSKLTENSVGLEHLAPGAVNADKIAVRSIVSSHLGEGAIQNQHLADGSVDLSKLSDEVKEMLDRAPVVLPSLIQSPAPTSIAEGSVTTAHLADGSVDSTKLAQGSVAPAHLSFLPVAAQQSGVSIAFGAKPFMFHGTSESTELTVTFDEPFSHDSYVIVAMSDHPSCSCFLRVKRENEAVIEIVRTRLGPEPVGFIQWVAIGQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP61</accession>
    <name>A0A398CP61_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03089">
        <property type="protein sequence ID" value="RIE03089"/>
        <property type="gene ID" value="D3H35_21145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="239" mass="26639" checksum="879489AB4E5A2736" modified="2018-12-05" version="1">MKLFLLIFCSILACVVTLGIFSYSKSSSIIKNKVAEASRQTAEQAAGKFSLLFDGYERLSLQFITDSGFTDLINTLAAANDDYEKFDMSRKLTEKMSGMAMSDSTLESISLVPVNEKDQTMTTGGTLRREGLTSTPILEKIKEGSGKAVWIPTMTKGVDGSRTFPTFAVGRYLSLGKQYYLLIEIKQRYSIRSCKPFNSAKEARATSSRRTVHRIRARQWEAGHKIFVRAAGGIRYGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP64</accession>
    <name>A0A398CP64_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysM peptidoglycan-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01677">
        <property type="protein sequence ID" value="RIE01677"/>
        <property type="gene ID" value="D3H35_23220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="165"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="216" mass="24281" checksum="F69C0898F77815F6" modified="2018-12-05" version="1">MEYSIQLSFNNGDEKLKIPILPEILEIKGSGNGKTYTVVGLGEINVITARSLKGISFSSFFPAVNYPILQETKAVFLMPAKYVQTIERWMATKRPIRFVFSGHYDINIPVSIESFEWSEIAGSGGDIEYKIELKEYRFYAAQTVTINKKTVSKKPARPNEKQVPKTYKLVAGDSLYKVAQKILGDASRWPEIQKLNGIKDAQLKSLQIGMVIKLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP89</accession>
    <name>A0A398CP89_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_06165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04202">
        <property type="protein sequence ID" value="RIE04202"/>
        <property type="gene ID" value="D3H35_06165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="166" mass="18073" checksum="1C07AB7F1A0185C5" modified="2018-12-05" version="1">MDEVIEKLFSFLLGHIYIVVVVIGFIYSIFFRKSPIEKKPPNRMPDFGGGGSMLPQRPKRQTSPAGMPSAESSRPFSQQTASSDVRSLAERSEQSQASSAAFGSNSNDGESRYVALSAAGTPAVKAAVPIESSSEVPSVLTRTDMRRAIVWAEIIGPPRARKPFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPA1</accession>
    <name>A0A398CPA1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen synthase</fullName>
            <ecNumber evidence="7">2.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Starch [bacterial glycogen] synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glgA</name>
        <name evidence="10" type="ORF">D3H35_08510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Synthesizes alpha-1,4-glucan chains using ADP-glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18189"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.21" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03990">
        <property type="protein sequence ID" value="RIE03990"/>
        <property type="gene ID" value="D3H35_08510"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00484">
        <property type="entry name" value="Glycogen_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011835">
        <property type="entry name" value="GS/SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02095">
        <property type="entry name" value="glgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_5" evidence="9">
        <location>
            <begin position="25"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="8">
        <location>
            <begin position="287"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="494" mass="54589" checksum="8820694B342EDE28" modified="2018-12-05" version="1">MNKTILVATGHIDGAGRNALNLGIVRELADKGLDVRVITPLRRNREPEALAESRELGTIAVPMASDTVEGAVRQSIRNGIPFYWIDAPSYFDEDNVNGHMDDAERYSFFAKAVLESLLLMERLPDIIHCEDWPAAFIPYLKHVSDLENGRKPDRIRTVYTFQSIGSQGIFDIEAAAHLDLDAEALSASGLDYYEQLNFMKAGLLYADALTTVSPTYAREIGTEMGGMTMESIVNARRDRLRGIVGGIDPANWDPENDPELPANYGIGRMEGKRISKARLQEELGLPIRADVPVILYHSELSCERGADLLRYSLADILKSDMQLVVMPAEEGSRGFEEETFAAFFSEAASSKEGKLRFLPYERGRIKRLFAGADIYLMPSASDSGGLEQLIAMRYGTVPIVRSVGGLADTVEPYDADSGKGTGFVFRYANEKVMLHSVREALRLYRDAEAWQVLAENGMGHEYFAARAAAEYAKLYDELADGEFAKALISVGKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPC2</accession>
    <name>A0A398CPC2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 3">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hpt</name>
        <name evidence="5" type="ORF">D3H35_23490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 3"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01341">
        <property type="protein sequence ID" value="RIE01341"/>
        <property type="gene ID" value="D3H35_23490"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="4">
        <location>
            <begin position="12"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="180" mass="20045" checksum="F5EE2E5E9673FA15" modified="2018-12-05" version="1">MQNDIQEVLYSEEQIRAKVQELGAALSRDYEGRNPLVICVLKGAFIFMADLSKNIAIPIELDFMAVSSYGNATRSSGEVKIIKDLDASVEGRDVLIVEDIIDSGLTLSYLIDVLERRNALSVNVVALFDKPGRRTVELQADYTGFVIPDAFVVGYGLDYAEKYRNLPYVGVLKPEVYSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPE1</accession>
    <name>A0A398CPE1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxypeptidase regulatory-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04030">
        <property type="protein sequence ID" value="RIE04030"/>
        <property type="gene ID" value="D3H35_08740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="334" mass="35895" checksum="C0D81B95670E0AC5" modified="2018-12-05" version="1">MEVPYRGHGVRHVCPKSDGRSVCLCGVAGESGSRLRICQTSRSGVRANEHSDRGAAPPQIRDIGIEALDEDAGKYRLTINDYAVDRAAGAEPFFFWKTEDGYFSGFSDDYTSVEFVANPGTSGKSLEISAYVGDNLGYIGFKTVAVQGSRISHQDGVQLQLTSQPAELKGWDRYDIQYDARLIFGGKVVPGTSVDIYYTVDGTSWQPVTSGLISGNRYTWLVPNVNAGNVRLKLVAQNGAYIKSIESDVFSIAPSYYIEGKVLDKAGHGASGVSVSAGGAAVVTDSDGSYFIKVTGPGTYSVQASKTGVGFVKSSFDVTLDGKNYYDTKIFRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPH7</accession>
    <name>A0A398CPH7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_06570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04483">
        <property type="protein sequence ID" value="RIE04483"/>
        <property type="gene ID" value="D3H35_06570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="39"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="238" mass="26282" checksum="B416D15219CDB778" modified="2018-12-05" version="1">MARQEIEVKGCVTTLTERLADVEKRLQDACLRSGRRREDVNVIAVTKYVSVETAQGAVEAGIRHLGENRWPDSKDKWEALNGQAAFHFIGSLQSKKAKDVVGRFAVIHSLDRLSLAEAVQQKAALLGIEVPCFIQVNVSGEDSKHGLTPEEVVPFAEGLAAYPLVKPIGLMTMAPHETDPEATRYVFRGLRELRDKLNDGIFRDRPLTELSMGMSNDFEVAVEEGATWVRLGTVLVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPN3</accession>
    <name>A0A398CPN3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">16S rRNA (Guanine(966)-N(2))-methyltransferase RsmD</fullName>
            <ecNumber evidence="4">2.1.1.171</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rsmD</name>
        <name evidence="4" type="ORF">D3H35_07655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.171" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04503">
        <property type="protein sequence ID" value="RIE04503"/>
        <property type="gene ID" value="D3H35_07655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052913">
        <property type="term" value="F:16S rRNA (guanine(966)-N(2))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00095">
        <property type="entry name" value="TIGR00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="199" mass="21722" checksum="E391C17FEEFC92FB" modified="2018-12-05" version="1">MRVISGEAKGRPLKAVPGNTTRPTTDKVKEAMFSIIGPYFDGDRVLDLFAGTGGLGIEALSRGAGEAVFVDANVKSIEVIRQNLDATRFGERSEVYRMDARKAIAYLVRKGTAFDLLFLDPPYATKDCDLLLQELASKGLVADKALAVVEHDSKFAYDEAFGGFTLKRHVKYGEIALSVYRYDAGRNDAETSSDEGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPY0</accession>
    <name>A0A398CPY0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Recombinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01511">
        <property type="protein sequence ID" value="RIE01511"/>
        <property type="gene ID" value="D3H35_24465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="1">
        <location>
            <begin position="10"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="64" mass="7128" checksum="112F427A280209D4" modified="2018-12-05" version="1">MIPAKSSCTAIYIRVSLEEQAKYGFSIDGQLNELKQYCKLNKLGIHDTYIDRGLPAAKQPDVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ00</accession>
    <name>A0A398CQ00_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YafY family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_14095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01907">
        <property type="protein sequence ID" value="RIE01907"/>
        <property type="gene ID" value="D3H35_14095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="322" mass="35892" checksum="891D4321F65C34EF" modified="2018-12-05" version="1">MRAGRLLVILASLQRYGRRTAKELAEELEVSERTIHRDMEALSASGIPIYAVRGAQGGWVMQEGYRSRLTGLTTEEIRSLLMLQSSSVVKDLGLGGDMRNAFNKLLSALPDAARTDAEFVRERIHVDGAGWHSADPEENRHLAVVQEAAWTERKLRFTYRQPGSSEDKERTACPLGLVAKQSVWYMIAAAEEGDEPRTYRISRIRTAELSDQSFERPKDFALADYWERSTLLFKASLPRYPATVKIAAGAAERFRRERYVRVAEESPAEDGSIEAKAEFHTMESALEIVLAYGRRIRVIAPAALAEAVAAEACAIAALYEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ24</accession>
    <name>A0A398CQ24_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_12045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03399">
        <property type="protein sequence ID" value="RIE03399"/>
        <property type="gene ID" value="D3H35_12045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003790">
        <property type="entry name" value="GHL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02638">
        <property type="entry name" value="GHL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017454375" evidence="2">
        <location>
            <begin position="29"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="4">
        <location>
            <begin position="56"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="GHL10" evidence="3">
        <location>
            <begin position="154"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="533" mass="58450" checksum="9B0F782A2D86648A" modified="2018-12-05" version="1">MKRKAKGIGLAMALLLTMIGAGEPVAHAQGSVPDIRIYLDGNRVQSDTAPFIVPKANVTMVPMRVIGSGLGAETDWAQKTKTVTIRKPGKTIVMTIGQKYATVNGSRVALDTSVQLVNSRTMVPLRFVGEQLGLTVKWYGDTRTIALESEAAAELRGAWVSTVYNLDWPSKNSYGNAEQQKLEFTQLLDELQGIGLNTVFVQVRPTGDAFYPSAYAPWSAYLTGQQGKDPGYDPLAYMIEQAHARGMSFQAWFNPFRAAVSSNTAVLAPGHVALTHPEWIVAGGSGILYVNPGIPEARQYIIDTIMEVASKYPVDGIHLDDYFYPSSGAFDDSAAYAAYKGSQYATLGDWRRSNINDFVEKLGKAIHKAKPKLDYGISPFGVWRNAAVDPTGSDTRAGVTAYDDMNADVRTWIRQSWIDYVIPQVYWSQSLSVARYNTIASWWAKEVDGTGVKLYIGHAPYKLGTKETGWNSADEIINQLKYNETIPQIRGDVYFSAKDLRRNPLGLVPLLSAYYGAAPSTNGATPMPSEQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ40</accession>
    <name>A0A398CQ40_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_24690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01551">
        <property type="protein sequence ID" value="RIE01551"/>
        <property type="gene ID" value="D3H35_24690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="538" mass="62601" checksum="3EADA2CBF1C8D641" modified="2018-12-05" version="1">MEKNITKRVKYYTNFMSLYEFLVDAQYSSPNQDDDFKGEIEIEPEMLKRLVHQFNKLYISRRKGYLVQNHFQVHERGKAFVYKDQTLSDTVLQNHLLGKQTIACYPCNAYSTKWFLFDVDVALNGQDAIILAKRCTKRLITTLKEYISEEYIHCYRSGSKGYHIVIYLSEPVQRKRIEEFQQCIIAMAGLQGLKNADVEIIPQITNEKKQGKTAKLPLGRNHINLEYGSNFCCLVNLDTLEYKPSQYRNFLDIDPLDRDSFNKVADVVKEIAPVAKKQHIPMRRIEKKVEIAPRVLQENDIFSFCNSYEVTAHGQRHDMTFDLALRLKNDYKLSQKETEAALLDWLDNQEGRYGSSRVEAIRDTKFQAQYVYSRGYELRGKLIHSIVVTRDEAAFFADIVNEENKIGIMERNAMTVLVAFIRHAKLFGDNQFFMSYDQIEGISDVRRMAINPCITRLEHLGKIEIIERIDFKKGITKANRYKIALDVMHEESTKGYTIHYDSKINVLEILSAFYSVTQLKSMLTKSLYNNILESQESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ42</accession>
    <name>A0A398CQ42_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04330">
        <property type="protein sequence ID" value="RIE04330"/>
        <property type="gene ID" value="D3H35_06945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="69" mass="7290" checksum="CD4212E6AA5669F5" modified="2018-12-05" version="1">MAMAAKGKTIKKKKASSESQRPQMKIVTSDVCAVCKTPCDRGISYLARLSLPGAVGNGVPCVLTLPVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ77</accession>
    <name>A0A398CQ77_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Undecaprenyl-diphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_12430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03459">
        <property type="protein sequence ID" value="RIE03459"/>
        <property type="gene ID" value="D3H35_12430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03385">
        <property type="entry name" value="PAP2_BcrC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033879">
        <property type="entry name" value="UPP_Pase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="56"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="195" mass="21757" checksum="C0373709D63D4978" modified="2018-12-05" version="1">MNVNLFRLLNDLAGRYDWIDDFMEFCAQDIVWIMLAVMALLWLSGKTANQKLVFYSGLSAAVALIVASFLLSPGINHPRPFVGHTVHQLIPHAPDPSFPSDHATLAFSLAFGVWFANRRLLGAHLFLLALLTGVARVYVGVHYPADILGAMVLSLITCFAIAKMNRRMDAAPMLFIRLYRKLTNKLSLAFLPRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ94</accession>
    <name>A0A398CQ94_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Redox-sensing transcriptional repressor Rex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rex</name>
        <name evidence="9" type="ORF">D3H35_04140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transcriptional regulatory Rex family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04683">
        <property type="protein sequence ID" value="RIE04683"/>
        <property type="gene ID" value="D3H35_04140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051775">
        <property type="term" value="P:response to redox state"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01131">
        <property type="entry name" value="Rex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009718">
        <property type="entry name" value="Rex_DNA-bd_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022876">
        <property type="entry name" value="Tscrpt_rep_Rex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35786">
        <property type="entry name" value="PTHR35786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06971">
        <property type="entry name" value="Put_DNA-bind_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CoA_binding" evidence="8">
        <location>
            <begin position="79"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="7">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="90"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="210" mass="23505" checksum="158BF04BA8659071" modified="2018-12-05" version="1">MKQDKISEAVVRRLPLYLRYLNELTISGVQTVSSQDLGDKLDLNPAQIRKDLAYFGEFGRKGVGYNVHYLIEKIRQILKLDKILNVALVGTGNLGRALSNYSMYIRDNMKIVAVFDSDPSKYGTFINRLTVQPMNELSETVKRLDITIGIITVPATEAQNVADRFVEAGIRGILNFAPSVIKAPSGVRVHHADFTGELLSLAYYMDHEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ96</accession>
    <name>A0A398CQ96_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-layer homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02027">
        <property type="protein sequence ID" value="RIE02027"/>
        <property type="gene ID" value="D3H35_14785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="1174"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="1246"/>
            <end position="1318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1320" mass="145769" checksum="BE4E9E6A5701BCB5" modified="2018-12-05" version="1">MPIHNLSWLLSIANTYFLQKGEIRIMQRIKRPLVWLMMTLLLVSLFPSELAQRANAASAATYFIPDITQIRQSALYTMDSSGTIITRDNVYKTTNGALTITGTFSYVSKDTMKVKVEQLNYQSNKWVPDATRVVNAAVLAQDGTTNRFAANNLALFSGFNRITFSGMQGGIERSDTFFVLYDKVPFLTALKVVGGGPSEINLNEGSQAVVEKSTVSLQGVAQNATKVTVALNGGTAAITSLLEDGTFFSPALNLRSGVNSLNINVQNGSDSINVLRTIYYFDKDNPLTKLEIVHSSGEYPALGTIPTITEFGSSFALKAQLLVPYDDAPFDGTAIYSFQLKGDSSADIVTDTVTVDEAEIIIPGPDGVTPKYRLVTFTTADHPYDDSVLNQEATLSVTYGTFGTAKTAKFKSMPGNTLISAMYYLPDFDESTNTDVSSQTQVPLKGAQVGKSDFYILVKADKAPSTGLDGVYLPLSTTAINLTQVSGATVPDPVYEVYKISGFLNGQQKVQFSYSAGANYIADITYISQNYIYVADIYDGQTYEFDSRLESSLKISGEFIGFENFTSDPEYFVNGTVPTDSPDIDLTEDFDPAANSYKFQLELDIKPEGPLVYGENRIVFVARTDGGSGGVVREVRKEIKIYITDKNVSKIAKFMPAPVPVDTRPEFVLQDFASPSTDVLYNDLISKLFAASTDFAFKNDKYVTSRTTYDLVIRGSGASVLNLKLGSETILNLSIPKEEDEDGVGGIEKLIKLREFTMNDKKYYYDFSGDERDFIVRVRDLEFPEPGSHVYNLELINGTGARSTQRLEVARELSSYLLLAPQPTVGDQIIVNKNFVRFDIEAEGATAVFIDKYQAVEQPNSRFTFDYSDLKANKVTAIKIRVVRPSQTINDTVSVMYTNSIQIDSQYMEPLKTKHSIFNKQIELTFPKGTILKSAYQNGSGITKFYTETKLLFGIADPTDGVVERRNDYGHIINNGVSTVTIQDYLVSRFRSSANTQNFTTISNIFWINGGEGELGDKGTSGYIPATNGLAPYSTEGNFTEFPLERKVVPSNRGELTLSYNSNVVDEIGYTVSVFRYTDRGVWENIGGEVNTKNHTITVPFDDFGYYMVTKLKRGYNDITNHPWARNVLNALYSKGIMNNLRFDEFGADDQTTRGEFATLLVKGLNIPLNYDDKNTFFDILPGTSTTTWSYEYIETAARAGIVMGKSEGFFSAGTRVTRQEAAVMIARALKLKLSLNDKKLEAKLAKSFVDSSRIDFYARPAAEAVNKAKIMMGSEVTVAGQKKPVYNFNAEANLTRAEAGQIAVKMLQLKTNIFPKNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQA1</accession>
    <name>A0A398CQA1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diaminopropionate ammonia-lyase</fullName>
            <ecNumber evidence="4">4.3.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dpaL</name>
        <name evidence="4" type="ORF">D3H35_24975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.15" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01601">
        <property type="protein sequence ID" value="RIE01601"/>
        <property type="gene ID" value="D3H35_24975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008838">
        <property type="term" value="F:diaminopropionate ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010081">
        <property type="entry name" value="DiNH2opropionate_NH3_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019871">
        <property type="entry name" value="DiNH2propionate_NH3-lyase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03528">
        <property type="entry name" value="2_3_DAP_am_ly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01747">
        <property type="entry name" value="diampropi_NH3ly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="41"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="414" mass="44863" checksum="EDE8E893B1D45722" modified="2018-12-05" version="1">MIHSLKTVVNPRVNKDSKARIAELFGDEEIGKAVRFHRSFPQYEPTPLVSLSQLAQRLGIKGVYVKDESFRFGLGSFKVLGGSYAIGRLIAERAAVDSGSMTFEELKSDAAREKAGEMVFATATDGNHGRGVAWTASQLGHRSVVYMPKGSSLTRLQHIRDAGAEASITDWNYDDSVRIAASEAEKYGWEVIQDTSWEGYVEVPLHIMQGYATMAQEALSQLQESEAAGPTHVFVQAGVGALAGAVVGYLNAEMEKSPTVVIVEPNKADCLYRTCKADDGQLHRVEGDMDTIMAGLACGEPNPLGWEVLREYADVFASVPDGVAALGMRVLGNPLQGDPRVISGESGAVTAGLLSMVMEDENYARIREEIGLNADSVVLLFNTEGDTDPYMYRKVVWDGYGKVPKSDGRGEQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQD8</accession>
    <name>A0A398CQD8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Efflux RND transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01641">
        <property type="protein sequence ID" value="RIE01641"/>
        <property type="gene ID" value="D3H35_25220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="562"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="613"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="642"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="680" mass="72478" checksum="BEC132779DC58CA3" modified="2018-12-05" version="1">MYGTLFCVLIIFLFLRNVRATLISIISLPISIFATIAVMNQMGYTLNIMTLGGIAVSIGRIVDDSIVVIENIYRWKQEKGEQLKGKELAFQATREVIGAVASSTVAMIVVFAPLAFVSGIIGEFFRPFSLAVVISILTSLLVAVMLIPVLGSKFFKRVKPHKQGGRLTDGFEKVIRGALKRKGIVLGASVLLLIGSLSLIPLLGVAFLPAGSVPTASIGITLPSKSGLEQTDKVSAKVESYLKELNETESYSVSIGSSGGNPLASSGGKNKATVTAQFVDGTDIDQLVDRMNTELPAIVTAEEEGTAINVKAGEQEGLVTGNNIDVSVFANNADNLAKAAQQIESLMKQSSDLKDITNNMNEVSPKWVLTLNQQGIDANVSPLLIMQLVGEQLRPVDAGTYTIDNKDRDITLSYDRQITSREELENVQVPTVGGLKKLKDVADITQQNAWIQVNHDDGKMYAQISGTVKKSDEVSAVTKKIEDNINSLSLPSGVEVTIGGGQQMIAEGFVNLGIAMVVAIGLVFLVMSMTFGGLLTPLIILSSLLFIPVGALGALFVTGQSLSMSGMIGMLMLIGIVVTNAVVLLDRVEKNRKSAGMPITEAIVEASKTRLRPILMTAFATMLALVPLALSGSSTSLISGGLAITVIGGLFTSTLLTLIVVPVVYELAWRKRKTKEAETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQJ8</accession>
    <name>A0A398CQJ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_10850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03539">
        <property type="protein sequence ID" value="RIE03539"/>
        <property type="gene ID" value="D3H35_10850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="1"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="415" mass="44586" checksum="E7E764B689D63945" modified="2018-12-05" version="1">MAADDKKIVLRIAWITALCLIGDSMLYIVLPLYWKEAGLGSLFEVGLVLSANRLIRIPLNPLIGWLYGRIGIRQGLILSIVIAIATTASYGIAEGFLFWIFARCLWGVAWSFLRLGAYYVIIELRSSNELGRLFGIYNGNYRLGSLFGMLAGGGLAQLYGLRQTALALAVFAFCGIAAVYRKGVFEATGGADPIPKRTEARSTISRGIGRRFITGGVIALLLSSFTSSLIYEGMFTSSLSHFTEARHPSTTFLGLSFGSALLAGGLQALRWGWGPALSPFIGALSDRNGSAVPMIVAISLFASGLFLLFPMSLPSTLWIVVTIGILLTATGMSTLLDVLAASIASRHPGTERNVMTVYSMTLDLGAALGPVAAFWAIQRTNGATLYWASAILLFSLSASWRFQSVRGAKATPRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQQ6</accession>
    <name>A0A398CQQ6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Molybdopterin oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_15525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02157">
        <property type="protein sequence ID" value="RIE02157"/>
        <property type="gene ID" value="D3H35_15525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02786">
        <property type="entry name" value="MopB_CT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037920">
        <property type="entry name" value="YoaE_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="686" mass="75104" checksum="D7BFCA4AA564541C" modified="2018-12-05" version="1">MTAATTTTARSVCPFDCPDTCSLSVTIEDGRITAIDGDSEHPVTQGAICNKVRHLHERVYHPERLQYPMRRKAGAGKGTLDGFERISWDEAYELMTARMRHTIREHGAEAILPYSFYGNMGILNAEGMDRRFFHRLGASRLDRAICNAAGSAGYRYTMGGSFGIDPEDTVHSKLILVWGCNIVSTNMHQVVYATEARKRGARIVHIDVHRNRTSAWADEFIAVLPGTDTALALGLMHVLIKEGLTDKKFLAAHTVGYEELAAKAAEYTPERVSGITGVPADKIVALAREYGAVSPSFIRIGNGLQHHDNGGMAIRTIACLPALTGQWSILGGGAIKGNSGYSELNNDGLERPDLLPDPNVRTINMNQLGDALLDAEPPVRILFVYNSNPASVAPDQNRVRQGLMRDDLFTVVHDLFLTDTCRYADLVLPATSHFENPDLYASYWHLYMQLHEPVIETIGECKSNFTLFRELALRMGFEPELFDLTEEEMIREALDCPSNPSLAGITYEKLAAEGWAKLNLGGSLSAVPGRLPTSSGKIELYSEAMKLAGLPPVPEYEPIAKEEEPLPFLLVTGPNHSFINSTFGNQSRLAKLEKRPALHMNDADAETLGVRTGDRVIVRNGRGEVRIAVKAGADVLPGVLVTQGLWWEEGNEGVQAINTLTSQRLADMGGGATFFSTRVEVTKGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQT1</accession>
    <name>A0A398CQT1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_10585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000033">
        <property type="protein sequence ID" value="RIE03629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03629">
        <property type="protein sequence ID" value="RIE03629"/>
        <property type="gene ID" value="D3H35_10585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="84"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="309" mass="35081" checksum="30F8C0B7EF6FB315" modified="2018-12-05" version="1">MATAAFKKKKFDVNQISVGSNLAINSFFWIYTALCVFPLLLVIAVSFSDEKTVLISGYSFWPEKWSIESYKFLFNDYMAIVKSYGVSIFVTVVGTAISLTIMTMYAYPISRRDFKHRNLFSFLMFFTILFNSGLVPFYLVYKQGLHLQNTMLVLMIPLFVQGFFVFVIRTFFQNQVPPALIESAKIDGAGELRTFFQIVLPLSLPVLASVGLLVTLNYWNDWFLSVLFIRDDGPQTIQFRMYRTLLDIQYLSSNAQAYSAIMQANPNFTVPSETARMAMGIVGIGPIIFLYPFVQRYFVAGLTVGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQW1</accession>
    <name>A0A398CQW1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fucose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03659">
        <property type="protein sequence ID" value="RIE03659"/>
        <property type="gene ID" value="D3H35_10185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005996">
        <property type="term" value="P:monosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="477" mass="53250" checksum="2881AC1432491432" modified="2018-12-05" version="1">MKKLKLGYAPTRRFTFSEVDAFKYKVLIREKMESFGMDIDIVDLEGLNEEGLLYDDHIGADQIVDRFRKEDVDAVFFPHCNFGTEDTVARVAKAIGKPTLLWGPRDEAPLEDGMRLRDTQCGLFATGKVLRRFNVPFTYVTNSRVDDLVFERGFKNFVAAANVVRQFRKLRILQIGPRPTSFWTMMCNEGELLERFGIELYPITLIDIQNAAKKVEKANGPALKEAVSYIHNKLEVMAEVPPEAVTRVAALKVAMKNYAEASGSTAIAIQCWSALQDAIGIMPCLANAILTDEQIPVTCETDIHGAITSVMVQAGAMNEAPTFFADLTIRHPDNPNGELLFHCGNFPVSLSVEDKPKMRRHFLFDDHAPGTHEGEIRGGDMTLARFDGDHGEYSLFLGKAKGIQGPYTRGSYVWVEVNDWPLWEEKLVKGPYVHHSVGIHANVIPALYEACSYIPGLTPDPVDPTEAQIKAWLRGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR22</accession>
    <name>A0A398CR22_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE04983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04983">
        <property type="protein sequence ID" value="RIE04983"/>
        <property type="gene ID" value="D3H35_02205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="134" mass="14842" checksum="AC5CBDDF55D516AF" modified="2018-12-05" version="1">MLTTIYPVLLDKFDRQPDAAEFMVAMSGHLTVSLLGFVISVLFTSKWVPKLYMSTGGLLLTMALSIAGQGIERSLPHAWRGLAWLLPPAYKTIAMLSGYEAANGAEIALGLFLPLFYAFLGAVIFLRRMNRRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR60</accession>
    <name>A0A398CR60_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_03875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04640">
        <property type="protein sequence ID" value="RIE04640"/>
        <property type="gene ID" value="D3H35_03875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017363253" evidence="2">
        <location>
            <begin position="27"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="3">
        <location>
            <begin position="65"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="377" mass="40193" checksum="6B9E98E9F9E21B05" modified="2018-12-05" version="1">MKTWRRSSLGLALVIAIVLVLSACGKKENNDGASSSPSASPTASQAASPEASADSKIEALKGKKIAVVMQFNQGTLSAQYLEGVKSQVEKFGGKLTVLASENDLNKMVTNLDNAINQKFDGILLDHGNADALTAGVNKALAAGIPVVAFDSGLSIEGVTSIAQNDQLLADKSLEALAKDAGGKGNIVKVWVAGFPPMESRQITYKAFQAKYPEIKEIAQFGDASKAQLDAQTQMEAVLKKYPEKGSITAVWAAWDEFAKGVTNAIKQAGRTEIKVYGIDLNDEDLALIQDPESPWVASAGADFTSIGQVQVRYLYQKLYGDKAEASVQIEPAFVSRELLPTDKKVTVADLGEYVPGWGKSEQGVTDYLTQLEQSVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR99</accession>
    <name>A0A398CR99_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_09555</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03789">
        <property type="protein sequence ID" value="RIE03789"/>
        <property type="gene ID" value="D3H35_09555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="65"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="357"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="392"/>
            <end position="399"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE03789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="613" mass="69329" checksum="55681DF5F56C9797" modified="2018-12-05" version="1">MEPIWFFIRRLYEFTGNKILFNVSGMVFVSFLEGLGIVMLVPMLTLSGMSGLQDDEVPLAKWFGFIHEIPAPWVLPAILGLFVLVVTTQSFLKRQVTLQNIKINQSFDLATRTETYRLLLQANWDFFIKRRKSDMISSLTSEIARINGGITLSLQLLATVIYTMIQIGLAFWLSPEVTAFVLASGIVLALFSRKFIRRAKKLGTQSTELARLYLAGITDQMNGIKDIKTHTLEYSRLGWMRAMSSRVLQEQSEFIKLKTTTQFFYQIASAILISGFILLSVQIFHTPWAQLLLIVIIFTRLWPRFTGFQSNVEQIASFYPAYKNVLRLQQECREAAEFAIGDEADHPVRPLEVKTSLECRDVSFRYNRQDERFALQNIDLEIPANRMTAIVGKSGAGKSTLIDLFMGLMLPEVGQVVVDGVPLTNAHLVALRRSISYVPQDPFLFNDTIRENLLMVKPGAEEGELWEALDFAACSEFVRKLPKGLDTFIGDRGVRLSGGERQRLVLARAILRKPSVLVLDEATSALDTENESKIQEAIERLKGKMTIIVIAHRLSTIRNADQVVVIDQGRIVQRGRFGQLAKDKRNLFSHLLGNQSDDESNAEGEERIRDVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRA1</accession>
    <name>A0A398CRA1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3343 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01444">
        <property type="protein sequence ID" value="RIE01444"/>
        <property type="gene ID" value="D3H35_24075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021778">
        <property type="entry name" value="Se/S_carrier-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11823">
        <property type="entry name" value="DUF3343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3343" evidence="1">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="81" mass="9111" checksum="1F0A9793FA2F6AAB" modified="2018-12-05" version="1">MEPLLIAFDSTQQALRAEMLLEYADIEIDIRPTPKEITAGCALSIEFPGESLNSVQEIIANEQVEIRGLFRKSDQGYEQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRB2</accession>
    <name>A0A398CRB2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_01350</name>
        <name evidence="2" type="ORF">D3H35_02835</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000013">
        <property type="protein sequence ID" value="RIE05298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05083">
        <property type="protein sequence ID" value="RIE05083"/>
        <property type="gene ID" value="D3H35_02835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05298">
        <property type="protein sequence ID" value="RIE05298"/>
        <property type="gene ID" value="D3H35_01350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="284" mass="31427" checksum="6B2E97A139E75C52" modified="2018-12-05" version="1">MKGNIPVIPTPFVDGKIDYEGFENLIRHTSDFVEGYVIGGSTGESPALSAEERIEIARFFAKRVPHMHIVIGLNHTNLEEAVAIGRAAVEAGIRSALVPSPYYFPNSLESVKAYVRSLAERTGLQIVFYDNPVTTKTVYTAQQLIELAAAVPAIKAIKMTDHNMGKIRALKQQTSLAVFGGDDIICFRAFEAGVDGNMIIAPIIYPKEFKECWDLYRAGKRQESFAVFSDKILPFIHMFGPGDEIPTTKALYKQLGLFKSAETRLPLLPSDEQRVSETLLGYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRB6</accession>
    <name>A0A398CRB6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02367">
        <property type="protein sequence ID" value="RIE02367"/>
        <property type="gene ID" value="D3H35_16770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="448" mass="50445" checksum="4F9D5E4202FCA950" modified="2018-12-05" version="1">MALILKFSEAIGLTTSTIEVISSFHSTCLDNERDLYVYLPPSYDSSTETRYPVLYMHDGQHVFAGDQFGESWEVHKTIDRLIGEDKLREVIVVAAASITHARLLEYFHDNPGIRSVFGDGSIGERYERFFVEEVKPYVDSRYRTLPDRENTAIMGSSAGGVASYHIGFRRPDVFGMVGILSPFFVLARTEGTEFVETPLYLKFDTHPPIRVWLDMGGAEGLMTVAHARDVAEELIDNGFVPGADLAFLLDSEAGHSQKDWADRLHSPLLYFFGRIGAPRSLEVHGRTKVGLIGPATRLYPNARYDSGFETSLLRAEYKALDPAIATVDPDGTIRPKSIGTAEIEVEFEGLRKRVTLEVVPEMSEMVEVDVTVEVAAETRDEDRVYVGFEIPRIKKGLYKGTFRLPRDLIFAVNVSKGFRSNEKGNVIRRFSTSEDLDLRYKVEEWEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRK4</accession>
    <name>A0A398CRK4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="4">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ispG</name>
        <name evidence="5" type="ORF">D3H35_07985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03899">
        <property type="protein sequence ID" value="RIE03899"/>
        <property type="gene ID" value="D3H35_07985"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="373" mass="39855" checksum="1F795FA80E9500B2" modified="2018-12-05" version="1">MFKRTDTVPVRVGNLTIGGNNEVILQSMCTTKTADVAATVAEIKRLEEAGCQLVRVTVNNKEAAEAIKEIKKQISIPLVADIHFDYRLALLAIENGIDKVRINPGNIGRREKVEAVVKACKEKGIPIRIGVNAGSLENHLLEKYGYPTPEAMVESALFHIGILEELDFHDIIVSLKASDVPMAIAAYTKAAEVIKYPLHLGITEAGTLFSGTVKSAAGIGVLLNAGIGNTLRISLSADPVEEIKVARELLKTFGLITDAPTLISCPTCGRLDIDLFSVANEVEEYISKLKVPIKVSVLGCAVNGPGEAREADIGIAGARGEGMLFRYGEMIRKVPEAELVSELKKEIDHIVAVYTETGEIPGRKHGAGAGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRV3</accession>
    <name>A0A398CRV3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05283">
        <property type="protein sequence ID" value="RIE05283"/>
        <property type="gene ID" value="D3H35_01830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="98" mass="9348" checksum="8F8DCAD78EE28589" modified="2018-12-05" version="1">MTAREGGILTPTATAAIGLSEAMGKPVPSVGLVEAAGGDSGVGGLWPPAASPLPVPSVGLFDSGLAVVEPVNSGRGGAGVAAGRSSLPRLNTLSRDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRV5</accession>
    <name>A0A398CRV5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000009">
        <property type="protein sequence ID" value="RIE05325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05325">
        <property type="protein sequence ID" value="RIE05325"/>
        <property type="gene ID" value="D3H35_01070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="77" mass="9009" checksum="F5643816E91EDC42" modified="2018-12-05" version="1">MPISMLRPQASSSLCWNKRTNSRHIRRSQPSTMRKTDTRSKPETPPDKPDKPDKSRKKQRATRLRCTCLIGTAMWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSM4</accession>
    <name>A0A398CSM4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2971 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03748">
        <property type="protein sequence ID" value="RIE03748"/>
        <property type="gene ID" value="D3H35_09325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="210" mass="24152" checksum="BCD9E6699BF6D75A" modified="2018-12-05" version="1">MPYTLEQWNKRIGGRTDLSTYITHLTRATSDLTTGKVLMKILSDQKIIGSNPGSPGFIVGNNPAVCFQDTPLLSLGQNILHEQDYRKQMEKSGVPKVKVRYLPYGLAFRKVYAYNKGARPVIYESTELAKTLLPEEEHWRIVNFNLSNKENIIDWTHEREWRIKGDFEFQLSEAVLLVSNETAYKWFIDNDNKNLLKKLAGVVCLRAVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT89</accession>
    <name>A0A398CT89_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Coproporphyrinogen III oxidase</fullName>
            <ecNumber evidence="6">1.3.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemG</name>
        <name evidence="8" type="ORF">D3H35_20890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>coproporphyrinogen III + 3 O2 = coproporphyrin III + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:43436"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="1.3.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.15" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03047">
        <property type="protein sequence ID" value="RIE03047"/>
        <property type="gene ID" value="D3H35_20890"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="4 6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="7">
        <location>
            <begin position="14"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="480" mass="51105" checksum="3D2601553D56EE99" modified="2018-12-05" version="1">MNTMKRVAVVGGGLTGLSAAFYLRRLAEEQGKSVDVTVLEGSARLGGIVNTLRKDGFVIERGPDSFLARKVAMYRLAEELGLERELTGTNPAARKTYMAGSGKLHPMPAGLNLGIPADLGGLARTGLLSPEGKQRALAELRLPVDPIDDDVSVGEFLESRFGREMVERLCEPLLAGIHAGDLYALGLKATFPQFADLAAKHGSLMRGMMAARLAPAAAGVTGAGIGLPDFVPKTAFLTFRRGLSSLIEALEARLRADEGCRVRTDSKVVSLAGSEGAYVLRMGDGSTVEADDVLFTLPAYATAALLESHADVMALKAIRYVSVANVVLAYDAADFHHRLDGSGFLVPKTEGRHITASTWTSAKWLHTAPEGKRLVRCYVGRAGDEAKVELSDEEMTAAVRNDLRHYMGIDATPEFVEISRLRHAMPQYPVGHVQAIAAFREGLSRDLPGVWATGAAFGGVGLPDCVSQGRDAAARILAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTA6</accession>
    <name>A0A398CTA6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_06815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04489">
        <property type="protein sequence ID" value="RIE04489"/>
        <property type="gene ID" value="D3H35_06815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="365" mass="40034" checksum="F7538D5DB5FC6FD7" modified="2018-12-05" version="1">MLAAHLKMTLREKQVWFWAIFFPIILMVLFMIIFGGGGDDRFQAKVAVVKPVANATADLLEDRLRQVLALEWKTELPVSAEQADEWIKEKDIDAVIELPETDNAKALKLIVNTENEQSATTQAISGILEKFVQQANLAEAGVEEQSAYQLQIRSVSSGSEDLNYVDFLLTGMIALSIAQGGLFGMVDLVEMRRNGLLKRLRMTPVRIGLFGLSDMTVRYLFGIVQMIILALIGIFGFGANLHIDFLTLFVAFSVGMLAFSAIGYLFSSFSKSLESYMGLANIASFLMMFLSGIFFSTAGLPDWLKPVTHALPLTYFVEGIRDGLAYGSGIGTGDFWAGGGILALWGAGAFSLGSFIYKRGREAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUM4</accession>
    <name>A0A398CUM4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04348">
        <property type="protein sequence ID" value="RIE04348"/>
        <property type="gene ID" value="D3H35_07050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="15"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="141" mass="15301" checksum="48C10D908A539166" modified="2018-12-05" version="1">MAFENPSREEIKQLLLGSKTIAVVGLSDDLAKVSHMVSSAMKDKGYRIIPVNPNADKILGEKSYASLSDIPEPVDIVNVFRRPEHTPKVAEEAVAIGAKTLWLQLGIANDEAARIAQDGGLTVIMDRCIKVEDSILLPHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV75</accession>
    <name>A0A398CV75_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02934">
        <property type="protein sequence ID" value="RIE02934"/>
        <property type="gene ID" value="D3H35_20205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="331" mass="36704" checksum="D6F511DA1EE042CD" modified="2018-12-05" version="1">MTNALVTGATGFLGQHVCLRLNRMGWNVTGMGRSESVGASLEKQGVRFVQADLRDEESVVRACAGQEVVFHCGALSSPWGPYREFEAVNVGGTKHVAAGCRKHEVRRFIHISTPTIYFDNRDRLDIREDDRLPAKPINAYAATKLLAERVAFQAFADGQPGLILRPRAIFGPLDRALFPRLMRANDSRGIPLIKGGNVRLDLTYVDNVVDAMLLGWEAPHEALGQAYNITNGEPAILRNVLEKLFAMMGVRLRTRTIPYPVAYGAAALLEWSHRMLPVLGEPALTRYTIGVMSRSQTLDITLARERLGYAPRVGLHEGLRAFAEWWSSIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVR5</accession>
    <name>A0A398CVR5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DeoR/GlpR transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_21305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03114">
        <property type="protein sequence ID" value="RIE03114"/>
        <property type="gene ID" value="D3H35_21305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DeoRC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="112" mass="12611" checksum="A8323D3606F38473" modified="2018-12-05" version="1">MSADAVDIHFGVSNTTFVEQNIKRLMLEAAKQVALVCDHTKFGNTALAKVCRLDELEHIITDEGISPSLREEMERLGLLSLLCNVQMESLKQMTCRSMLEAFSFAFIQRFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVS6</accession>
    <name>A0A398CVS6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pullulanase</fullName>
            <ecNumber evidence="3">3.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha-dextrin endo-1,6-alpha-glucosidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pullulan 6-glucanohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pulA</name>
        <name evidence="7" type="ORF">D3H35_13455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of (1-&gt;6)-alpha-D-glucosidic linkages in pullulan, amylopectin and glycogen, and in the alpha- and beta-limit dextrins of amylopectin and glycogen.</text>
            <dbReference type="EC" id="3.2.1.41"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.41" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03124">
        <property type="protein sequence ID" value="RIE03124"/>
        <property type="gene ID" value="D3H35_13455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051060">
        <property type="term" value="F:pullulanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10315">
        <property type="entry name" value="CBM41_pullulanase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005323">
        <property type="entry name" value="CBM41_pullulanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011840">
        <property type="entry name" value="PulA_typeI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024561">
        <property type="entry name" value="Pullul_strch_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045041">
        <property type="entry name" value="Pullulanase_PULA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43631">
        <property type="entry name" value="PTHR43631"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11852">
        <property type="entry name" value="DUF3372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03714">
        <property type="entry name" value="PUD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02104">
        <property type="entry name" value="pulA_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="6">
        <location>
            <begin position="482"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="948" mass="104958" checksum="D831C283CB4985D1" modified="2018-12-05" version="1">MRAVSAEATTELIIHYKPADKDTRDWSLWVWEDGKDGKPYKFTGYDAFGKVGKISLAGSVKKAGFIVRTEDWQKDVPGDRFIENIAGAAEIWLLPGDSRIYTSNPEEPEGPAKSFDEVKVKLHYFRYDDKYDGWNVWGWAEGKDGASYPLNGEDEYGKYAEFTVPNTKDSKRIGFVLRLSDASSDWANREFSDRFIEKINDDGTAEIWIAQNQEPVYYKDYYVDKSPKIIKAQLDDARVISFETNIPFPISGSGDEGFTLKTGDIQIPIASVKPINPDDKGVTRLARLTTSVDLDLRSSYTLVKENYLQATVTLGKIFGSASFDKTFYYAGNDLGATYTKAKTKFRVWAPTAAEAKLVVYAKWNDASGQEIAMTKAEKGTWTASLAGDQKGKFYTYKVLVNGKWNEAADPYASSVALNGDRGAIIDWAATDPKGWSTQKKPPFKNSVDAIIYELHVRDLSIAANSGIKNKGKFLGLTETGTKGPGGTKTGLDHIKDLGVTHVQLLPIYDYATVDESKLNTPQYNWGYDPKNYNAPEGSYSSNPADPSARVRELKQAVQALHQNGLRVIMDVVYNHVYSVDASNLEKLVPGYYFRYDENGKLSNGSGVNNDTASDHSMVRKLIVDSVKHWAKDYKLDGFRFDLMGIHDIETMNQVRKALDQIDPSIITIGEGWILGTALDSSLKANQPNAAKLPRIGQFNDSFRDSTKGSAFLLDQTGFVSGNYSVENSVKGGIVGGITYQPNIAQFAKSPDQSVNYVEAHDNNTLWDKLAFSNPKDSEATRIKMHKLATTVTLTSQGIPFLHAGQEFLRTKGGNGNSYNSSDAVNQLDWTRKAKYQSVVDYYKGVIALRKAHPAFRMTSAADIKKNLKFLNTKSGLIGYTIDGRAARDSWAKIAVFHNALRQPQQVTLPKGKWKIVVNGEKAGTKAISSVKGTTVTVPALSSMVLYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVV8</accession>
    <name>A0A398CVV8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000004">
        <property type="protein sequence ID" value="RIE05449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05449">
        <property type="protein sequence ID" value="RIE05449"/>
        <property type="gene ID" value="D3H35_00315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="103" mass="11775" checksum="73A917BD594A5B58" modified="2018-12-05" version="1">MVEALNQRDREWIRLLAEGSERDEAASLIGETDSVTSARTVAQRQPLPEEDRLVATLESEVAIERRGKGKRHLPFRFEFARLSPYSPWRLQSVERGPSEGKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWF8</accession>
    <name>A0A398CWF8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TlpA family protein disulfide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_10950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03551">
        <property type="protein sequence ID" value="RIE03551"/>
        <property type="gene ID" value="D3H35_10950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017292742" evidence="3">
        <location>
            <begin position="31"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="30"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="168" mass="18903" checksum="E9DE54A90284ADBC" modified="2018-12-05" version="1">MKIRYLYVGALMLALLIYAVWPQPAEEAEATIGESAPRIELTSLDGLTYALRPSSDDKLLVVNFWATWCEPCKKEARELQAFYEKHRDKVELVAVNLTSKDKEADVRTFATKYDLRLPVLLDEKSKAADAYHIAGLPTTYWIDSSGIVAGRKVGPVDRLFLEGLLPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWI0</accession>
    <name>A0A398CWI0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03571">
        <property type="protein sequence ID" value="RIE03571"/>
        <property type="gene ID" value="D3H35_11070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="85" mass="9678" checksum="09CCDF87BC645755" modified="2018-12-05" version="1">MQHLSSPSALFVTLFTLIKITFIIMRVIWIVTLPSRFTRTVHKNKLFYWFCDTKAGSSAETTIIAKIVETAYDGSILKDGDDRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXU8</accession>
    <name>A0A398CXU8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_00790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05358">
        <property type="protein sequence ID" value="RIE05358"/>
        <property type="gene ID" value="D3H35_00790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="71"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="347" mass="38634" checksum="BEE060C1A36943E1" modified="2018-12-05" version="1">MSEPTVYMWPKDNPHNKYTALLARSIERRGQRVVHYGRRSLFKPGRGDIVHLHWPSYTYQGSVFPITVAKSLFFMVLLIVYKGMGVRLFWTIHNIWPHTGKTRWDSFMRKRLLSLCDSAFVLSESVRREAAAAFGASEDKLVVTPHGHYVDAYVGRGTDIRSRFGIPADRFLFLFIGRINPYKGVDRLVEAYSSLSSEAGALLIAGQADAGYSLDFIGGKGNGSIKVHPHFVDDGELADYLQAADAVVLPYKQITTSGSAILALSYKKPVVAPRIGSLGEYVSEGCGVLYDPDDPNGLRQALRDSMNMDRKEAEKRISAKLGELDWDRIAGKMLRVYAGSIPQEVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY91</accession>
    <name>A0A398CY91_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Na/Pi cotransporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_06105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04191">
        <property type="protein sequence ID" value="RIE04191"/>
        <property type="gene ID" value="D3H35_06105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015114">
        <property type="term" value="F:phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005436">
        <property type="term" value="F:sodium:phosphate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044341">
        <property type="term" value="P:sodium-dependent phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003841">
        <property type="entry name" value="Na/Pi_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030147">
        <property type="entry name" value="NptA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="PTHR10010"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010:SF46">
        <property type="entry name" value="PTHR10010:SF46"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02690">
        <property type="entry name" value="Na_Pi_cotrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="331" mass="34121" checksum="DEF61C7D7595129F" modified="2018-12-05" version="1">MWASLLWFSVAGFALLLLGMKLTEFALKSWAGNRLSSWMSRATSTPFRGFLFGTAASALLQSSTAVTVLTIGFVNAGWMTLSRSFGILLGTNVGTCLTTELMSLQFHRFGGPLVLLAIAAWMLTAVGHELRVSRSDRGKPAGGILYIRYGSVAAAGLGLLFIGFGILQRMAPLLRENGYFNLLLNHAEKNAIWGLLGGAALAAAIHSSAAVIGMAMSLAGAGALPPEAGIAIVLGANVGTCFTGLVASLGGGRGGRFVALSQLGINGVGALLFLPLIPLLHSAAAALAPSDLSAQIAHAQTLFNVVSSVAALPIAYLFGRSVLAEPASPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYM6</accession>
    <name>A0A398CYM6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04331">
        <property type="protein sequence ID" value="RIE04331"/>
        <property type="gene ID" value="D3H35_06950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017301646" evidence="1">
        <location>
            <begin position="24"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="192" mass="21492" checksum="8EE2F25FA39605C4" modified="2018-12-05" version="1">MNVRKIALAVLVLTVIGGTAAFADNVSQKLRVIVNKQELVDGGVLVDGKAYLAVRALADSVQAILSWDDAEKKVVITKPNVHMFTMQDSTTFGSVSKGRNKFNIFSQIDNLKVDITAFKVTITDPYDDTTWLDGRDTSDKDFPDSGKDNFWFKTKEVSYDFKYSGKYVIRFWMKPKGETAFQVVSEKIISAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYU7</accession>
    <name>A0A398CYU7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsE</name>
        <name evidence="11" type="ORF">D3H35_02325</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05007">
        <property type="protein sequence ID" value="RIE05007"/>
        <property type="gene ID" value="D3H35_02325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="10">
        <location>
            <begin position="10"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE05007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="165" mass="17077" checksum="D1982650FEA6245D" modified="2018-12-05" version="1">MRVDPNTLELTEKMVQINRVAKVVKGGRRFSFSALVVVGDGKGWVGAGIGKAGEVPDAIRKGVDDAKKNLVYVPLVGTTIPHAVTGHFGAGKVLLKPASEGTGVIAGGPVRAVLELAGVGDILTKSLGSSNSINMVNATLEGLSRLKRAEDVAKLRGKTVQELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ28</accession>
    <name>A0A398CZ28_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Site-2 protease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D3H35_06070</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04184">
        <property type="protein sequence ID" value="RIE04184"/>
        <property type="gene ID" value="D3H35_06070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06158">
        <property type="entry name" value="S2P-M50_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044537">
        <property type="entry name" value="S2P-M50-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 16" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="15">
        <location>
            <begin position="120"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RIE04184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="240" mass="27437" checksum="935ECECB4B4A8ACC" modified="2018-12-05" version="1">MNFFWFPLEDLPFIVLAMLVAFTVHEFAHAWTAYKFGDSTAYEAGRVTLNPMAHIDWIGLIFLVVAGFGWAKPVPVRRSRFKRPRLMSILVTAAGPFSNLLLAFIVLFVFYALVAAGVMNDSSDAALATLWTFLKYWLQINFVLFIFNLIPLPPLDGYRIVEEFAPLRIRLQLQRFEQWSFFIFLLLVFVPPLRAATIGPLFELRDPIFRGMLDLLGTLFGSSVNESFINLLIKMQMTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZK0</accession>
    <name>A0A398CZK0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Catabolite control protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ccpA</name>
        <name evidence="8" type="ORF">D3H35_07085</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04354">
        <property type="protein sequence ID" value="RIE04354"/>
        <property type="gene ID" value="D3H35_07085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006377">
        <property type="entry name" value="CcpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01481">
        <property type="entry name" value="ccpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="7">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="336" mass="36854" checksum="740053EBDF847502" modified="2018-12-05" version="1">MTVTIYDVAREAGVSMATVSRVVNNNPNVKPQTRKKVYEAIERLGYRPNAVARGLASKKTTTVGVVIPDIANANFAEVARGIEDIANMYHYNIILCNADKRKDKEIRVINTLLEKQVDGLLFMGGAVTDEHVQAFNTSNVPIVLCATTDEKGVIPSVDINHEEAAFDAVNRLIAEGHRSIAMISGTLQDPANGFARYHGYKRALEQAGIPYREEYVRNGNYKYESGIEATQYFLSLPERPTAIFAATDEMAIGSIHALQDNGLSVPADVSVISVDNSRMASMIRPLLTTVAQPMYDIGAVSMRLLTKLMKKESVDHAKVILPHELIVRRSVAAPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0A0</accession>
    <name>A0A398D0A0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0291 protein D3H35_04640</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0291 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04901">
        <property type="protein sequence ID" value="RIE04901"/>
        <property type="gene ID" value="D3H35_04640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01103">
        <property type="entry name" value="UPF0291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009242">
        <property type="entry name" value="DUF896"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37300">
        <property type="entry name" value="PTHR37300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05979">
        <property type="entry name" value="DUF896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="62" mass="7242" checksum="00868984B135979A" modified="2018-12-05" version="1">MEKIIARINELSRKNKSAGLTEDEIAERDSLRRQYIAIFKGNFKQQLDSIEWTDDKPPSLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0E9</accession>
    <name>A0A398D0E9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04961">
        <property type="protein sequence ID" value="RIE04961"/>
        <property type="gene ID" value="D3H35_03220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="14"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="98" mass="10972" checksum="8B1CD57B42C72E3C" modified="2018-12-05" version="1">MCHRNSSEHGSWQRPLLKAGLFKTAEGDHLLLAVHHLVVDGISWRIVLEDLNTGYRQAMNGEAIRFPAKTDSYQTWAKALQGYANRAGVGRSRILASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0X1</accession>
    <name>A0A398D0X1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_03010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05141">
        <property type="protein sequence ID" value="RIE05141"/>
        <property type="gene ID" value="D3H35_03010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901575">
        <property type="term" value="P:organic substance catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="337" mass="37580" checksum="D78B0494A9872E86" modified="2018-12-05" version="1">MTKDHAGEWGMDIDQWDWVPGVGVIATLEYGEAVGRPEAMSYLERWIARNKEKAGQAKVINAIAPFAIFPALYRLTGDESYREEAVRAAEWLVSEAPRTREEAFEHTVTENVAFAEQVWADTVFMAVLFLARTAAMVGDEVYAKEAQRQVLIHLRLLEDTDSGVLFHGWNCGSRDHMSAARWTRANAWIAAGVPLILKETEPLIPAPGELRERYARLMEALVRFQQDDGLWSTVMDRPNYYRETSGSAGIAYGLLKAMDGGLIPYERRFKEAADRALQAISPFIADDGTVGGVSGGTPVMESVEAYDRVPIYPTLYGQGLVLMLLAESIRQEGDERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0Y7</accession>
    <name>A0A398D0Y7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_05045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04834">
        <property type="protein sequence ID" value="RIE04834"/>
        <property type="gene ID" value="D3H35_05045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="36"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="347"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="381"/>
            <end position="388"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="596" mass="65035" checksum="F30EF109401D0652" modified="2018-12-05" version="1">MNSNSEKTSRQTSRGGDWKSFLALIRRAKPAYSMFAVALALSLINTVVSLLVPLFTKDLVDGFSLNSLQGFQIALIAGAFVVQTVAGAFSIYLFNQFGQRILRGLRDLIWSKLLGLPVSHYDKNETGAMISRVTNDTNVIKQVVSDQLSGFITGIISIIGSVVILLSLDWRMTLVLLIAVPLTMAILVPLGKRMYTISKGMQEETANFTSVLQQVLSEIRLVKSSGSEPVEYKRGISGIGNLFKLGIREAKIQALIAPLMGLVVMMLLVVVIGYGGLRVSSGALSAGELVAFILYLIQIIMPLGQITGFLTQLQKAMGASDNLIVTLALEEERFDSGPSVPSVDKPIVLDHLTFEYEGTDEAVLKGVSFTIAPGKVTALVGPSGSGKTTLFSLLERYYEPTSGRILYGDADPIDNYSLSSWRSQIGYVSQESPLMAGTIRENITYGLNREVSDGQLREVARMAYAEGFIDELPQGFDTQVGERGMKLSGGQRQRIAIARALLRNPRILMLDEATSSLDSKSEVVVQEALDNLMQGRTTLVIAHRLSTVVDADQLVFMDKGVVTGQGTHEQLVATHELYREFAAQQLRYRDQSTSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D144</accession>
    <name>A0A398D144_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_01440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05211">
        <property type="protein sequence ID" value="RIE05211"/>
        <property type="gene ID" value="D3H35_01440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="70"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="261" mass="28643" checksum="A015E49C27DA60B9" modified="2018-12-05" version="1">MRFDYFARKRWNALAFGAALILVTLAAVTITEYNVVKGFTSIPEAIRWAVSNFYPNEKSLEKLPSIYDKLVETLLVSIASTTVAAVFGFVFAMMGSQAMGVGGALAFVSRSIATLFRNIDVAAWSMILLLSFGQNVLTGYFALFFGSFGFLTRAFMESIDEISSSSVEALRATGAGYLSVICQSVIPSVIPQLLNWILFMVETNIRHATIVGILTGTGIGFSFTLYYKNLNYNAAALVVIVIVGTILLIEWISNYVRRLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1B3</accession>
    <name>A0A398D1B3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_03235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04964">
        <property type="protein sequence ID" value="RIE04964"/>
        <property type="gene ID" value="D3H35_03235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024011">
        <property type="entry name" value="Biosynth_lucif-like_mOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04020">
        <property type="entry name" value="seco_metab_LLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="5">
        <location>
            <begin position="13"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="4">
        <location>
            <begin position="477"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="711"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="4">
        <location>
            <begin position="1066"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="6">
        <location>
            <begin position="1242"/>
            <end position="1315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1342" mass="152308" checksum="005E1D4ACC7D4AE2" modified="2018-12-05" version="1">MSREKKIDRENVSDILPLTPLQEGLLFYYLEDSSSEMYLEQLSLSMSGDLKDHVLVQAWDVVVENNDVLRSVFRWEKLDRPVQILLKEKKMKITFFDFTHLSDEESKAEIEKIKMKDRKKKIDIAIHPMRVLVCKVTEQSYEMIMTSHHILFDGWSYGILLKEFVDAYNDIFAGNKGEAKRTKSGYKSYINWIHNQDKHLENVYWSKYFQDFDANTLLPFEPKKGDDHRPKIGNLEYTCDEDFTSRILRFVKEQRVTLATLFYVAWGLLLQKYNDSEDVVFGTTVSGRNVKIEGIEQIVGLFINTLPLRVKTGQDEKVTDILQKILKDVHDRDAWSGSSLVEIKNNTKLSQNSVLFDSIVVVENYPLNDGLNSGNGKIGIDAYTMFEMTNYDIVLTLTTFGNIVIKLTYDENLISPSSMNQVMSHYIHLIENILRQPNASVHELEMLSQEEKHQLLTEFNRTDADQHDDKLIHEFIEEQTEKTPHMTAVRSGHVDLSYEQLNVQANQLASLLVSKYRIQPGDLIGVMLDRSVSMVVTLLGILKSGAAYVPIDPAFPVDRIRYIIEDSKIKTLITTSRYLEKCATTNLILLDQKIESMTGVSQLPVRNNRSSNDLAYVIYTSGSTGNPKGVMVTHSNVVNFFFGMDQKVPFDNDDCFLSVTTISFDISVLELLWTLSRGIPVVVHDSSDANNDQFDRYLSHQPLDVDFSLFFFSSYNDDEQNKYDLLMESTRFADEKNFKAVWIPERHFHEFGGLFPNPSIVSSALSTVTSQIQIRAGSVVAPLHHPIRIVEEWSVVDNLSNGRVGLSFAPGWHADDFVLAPEHYNDRVDFMYDCIENVKSLWSGKSIQQTNGLGKMVEIKTFPRPVQKELPIWITTGGSKESFVKAGKVGANILTHLLGQDRHVLAENIRSYRQSLQENGFDPESGKVTLMVHAFIGDDLEEVKRKVKPSFCEYLKSSVGLIRNLALNVGVNMEEAGLNSPLVMDELVELAFEKYWFTSAFLGTKESCTVTANELARIGVNEFACLIDFGLDKDSVMGSLVRLADMKNDLSSKSKSSKDDSAKIKPITIMQGTPSQIQMMYNDPTSRKFLGSLKTLLVGGEAFSERLADDLNLNIDARVINMYGPTETTIWSTTYTIRKESPSVLIGTPIANTKIYILDSRLRVVPVGVAGEIYIGGKGVAQGYWNREELTRERFIDSPFDEGGKIYRTGDLACWLPDGNIRFLSRKDYQVKVRGYRVELGEIESRLLHHPEISEAVVVATEDLDGSMQLCAFIVSKRNVESSEVKEHLMFSLPAYMVPAFFIRLDALPKTPNGKIDRKALPSHREYIPLRIDNTAPEMNWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1G0</accession>
    <name>A0A398D1G0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsM</name>
        <name evidence="9" type="ORF">D3H35_02370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05014">
        <property type="protein sequence ID" value="RIE05014"/>
        <property type="gene ID" value="D3H35_02370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE05014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="122" mass="13932" checksum="42DE15515EC7518C" modified="2018-12-05" version="1">MARIAGVDLPRDKRVEIALTYIYGIGKTTSQKLIASTEVNPNTRVRDLTEDELARLREAIDKSLKVEGDLRREIALNIKRLVEIGCYRGVRHRRGLPVRGQRTKTNARTRKGPRRTVANKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1R6</accession>
    <name>A0A398D1R6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000005">
        <property type="protein sequence ID" value="RIE05441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05441">
        <property type="protein sequence ID" value="RIE05441"/>
        <property type="gene ID" value="D3H35_00475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039650">
        <property type="entry name" value="HdrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498">
        <property type="entry name" value="PTHR43498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="65" mass="7029" checksum="2CBCCE2DA75AB098" modified="2018-12-05" version="1">MYQIPYRSLYSFNVNNLLFAGRNISATHIAFGSSRVMGTCASVGQAGRYRCCALCGEQGYPAGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCQ7</accession>
    <name>A0A398CCQ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00976">
        <property type="protein sequence ID" value="RIE00976"/>
        <property type="gene ID" value="D3H35_25805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="444" mass="51326" checksum="4589A14099185F2A" modified="2018-12-05" version="1">MGWQVNRSDSVALAVERAHDEIWRRFIHEQEGYGIVLDYAGLDGTVSLPTPEECREGKPNALAWWCPAENGAFFNGLYLDGLINRWKTTGEERDRIRAEKIALGLVRLGEVGDSPGFVARGIATDGRGHHFIGSDDQTAPWFYGLWKYVRSGLCSPEMKPRIERSVAAAAEAIVRLRWRLPCDRDFYAFRGDWRKAGFIHAARLLFVLKVTGELTGDRKWGDLYVEAGEEKPGGAGKTRFQWCETGLRDEPGSRYESDFLTKEVCAGQEKARTGGSRLRKYPYWTSASAQACLRELRELERDENRKLMFAAGLDHNAQRALAYIRKEKYTAYDNDNEIPFDIDWRFLNAWWKRQESVEDAVTVAEIQSREWHERSPRKVYEAQYVREPLWAAWFVALSGDPAVLKLAREPIRRLLTQYEWGKLYLSLFFIAECVYYEWLEHEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD50</accession>
    <name>A0A398CD50_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA repair exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_27125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00640">
        <property type="protein sequence ID" value="RIE00640"/>
        <property type="gene ID" value="D3H35_27125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="8"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="248" mass="27638" checksum="B2F971E5F951A385" modified="2018-12-05" version="1">MGTPGVSFTFIHAADLHLDSPFRGLDRADGAVRDRLRESTFAALRRLTALAKREKADFVVLAGDLYDASDRSLKAQLRLQRELEELTREGIGIFVVHGNHDPESGRQAKLALPEGVHVFGSDEVECFPAFRRDGRLAAHVYGISYPTPSVSDNLALRFRKREGAPFHLALLHGNVDGQPGHDNYAPCKLSELTAAGFDYWALGHVHDRRTVHEYPHVVYPGNLQGRSIRETGRKEPMSSACRMRDESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD80</accession>
    <name>A0A398CD80_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00663">
        <property type="protein sequence ID" value="RIE00663"/>
        <property type="gene ID" value="D3H35_27255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="151" mass="17113" checksum="F87961B192904407" modified="2018-12-05" version="1">MDTTPPSHSPPASKGSRNLGRLIMQLRRLERHPQTFGAAGSLTPSEIHTIVAIGYEEKILMSELAARLEVTKGAVSQLVVRLETKQLVTRSSYPHDSRAVLISLTEKGKEAYTAHEEVHLQFYDQLRSRLSRQEIEIFETCIEKLNEFLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDK6</accession>
    <name>A0A398CDK6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LytTR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01266">
        <property type="protein sequence ID" value="RIE01266"/>
        <property type="gene ID" value="D3H35_23035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH LytTR-type" evidence="1">
        <location>
            <begin position="64"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="126" mass="14827" checksum="DEC20544317FCD22" modified="2018-12-05" version="1">MLWNGAFNLMEDTEGLTGFKSVHADDILFFCVQQNQIVAHTLEKQYFTGWDSLDRLWRAVKASDPRYYRTDRVYIVNLSKVVLLDQEWCKLYFGDDSTSKHCYVARSRLLEVKQRMKLISDGMPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDW6</accession>
    <name>A0A398CDW6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_23690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01376">
        <property type="protein sequence ID" value="RIE01376"/>
        <property type="gene ID" value="D3H35_23690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015821">
        <property type="term" value="P:methionine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03258">
        <property type="entry name" value="ABC_MetN_methionine_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026253">
        <property type="entry name" value="ABC_MetN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041701">
        <property type="entry name" value="MetN_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43166:SF5">
        <property type="entry name" value="PTHR43166:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="261" mass="28640" checksum="3884D306DA43AE7C" modified="2018-12-05" version="1">MIVVNNINKTYRTPTQTVKALDDINLRVEKGDIFGIIGFSGAGKSTLIRCLNRLEEPDSGTIVIGDSVITDLGKNELRNARRKIGMIFQHFNLLDAKTVFQNVAFPLAVAGCAKKDIRPRVEEMLALVGLADKANAYPSQLSGGQKQRVGIARALVGEPDVLLSDEATSALDPHTTYSILELLADINRQLGLTIVLITHELDVLQHICRHMAVLENGRIVESGSVDKLFLHPESDTARRFVNITDNYRRRRFAVDGAGAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE27</accession>
    <name>A0A398CE27_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">tatA</name>
        <name evidence="9" type="ORF">D3H35_25730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms a complex with TatC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00963">
        <property type="protein sequence ID" value="RIE00963"/>
        <property type="gene ID" value="D3H35_25730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE00963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="78" mass="8572" checksum="FB54F1D265AC9557" modified="2018-12-05" version="1">MSGIGASGIILLVLIALLLFGPNKLPELGKAFGRTLREFKKGANDLMDEQPSDRNARRVEVSPQAENETPKAERRLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEW5</accession>
    <name>A0A398CEW5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D3H35_28850</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00422">
        <property type="protein sequence ID" value="RIE00422"/>
        <property type="gene ID" value="D3H35_28850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="131"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="198"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE00422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="391" mass="44490" checksum="6B2B92A85A962A0F" modified="2018-12-05" version="1">MVEVLRNPEWKSIALKALVLQLLFSVMMFFYMNNQVERINHTIVDQNAALIGHILKQEPQFESEIIRYITQGPQENEIAEGKQILAQYGYKANMSVADQPALSDQALPLKASIQVLFFAIPLLLLLLWEYRKIFSKIRTIAVAAAQVVERQFDKPLPENEEGDFGSLGRSFNAMAERLNNSLEQLKHEKTFLRNLLSDISHQLKTPLASLIVFNDNLLNDPKMKEETKNAFLERSRQQLARMEWLIVSLLKMARVETGTILFHNKEVQLRKLVNKAVHSLRALSEQKLLKVCISGGEEMLVEADEEWLTEAFLNLIKNAMEHSPKEGDIQIVLEQTSLFNTVHIQDYGEGIPPEELPHIFKRFYSGRSTAKPQSVGIGLSLAKSIIEGQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFD9</accession>
    <name>A0A398CFD9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_14085</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01906">
        <property type="protein sequence ID" value="RIE01906"/>
        <property type="gene ID" value="D3H35_14085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="1"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="393" mass="40868" checksum="B8EA96C410F8F4AE" modified="2018-12-05" version="1">MFTFVMFLIGTDTFIVSPLLPTLRAEFGIATDISGWIVSAYALGYALTALVAGPLSDRADRKKVLLVGLVGFALFTALCGTATGFASLFAYRLAAGVCAAFVSPQVWASIPQLVAPSQTLKTMGWATAGLSLAQILGIPLGSLLARDSWRLPFFGVGALCIVALIWIYTVMPAVPPRAVSAGGRVSIAQSYRMLWAAAGAPLAFSAHLLYFIGSFGSFTYLGIWLADRYALTVEQIGLFVLVYGAGNLTGSLLGARIAERWGKLAALTAALSAIGAAYLLAPYSPNAEIAAAACFFASFAGGQALPLILSSLQGLNSSLRGTISSLANAAMYVGTTAGSALSGWLYVSDGGFKTVGMLVAVSMAGALLLFRRSGIVRADRTGLKQARSSLADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFJ2</accession>
    <name>A0A398CFJ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01493">
        <property type="protein sequence ID" value="RIE01493"/>
        <property type="gene ID" value="D3H35_24375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="381" mass="42758" checksum="A72F560CE67CA66C" modified="2018-12-05" version="1">MTLSRTLTGLLILIGLALFCYAVPTFYLELRDHCIGQECAAYYDEPPTMEWLTERGLTPSFFAAAYTSLYSLFGLCYIAAGLVIFSKRSSGFAGQVASVALVLQGLTFDSLSLALEGIHPALDFLLRFVNAIAFVALILLFFIFPNGRFEPRWSRWLLVGILVPGLLKTAFPDSPVDMSSWSQPLYIGWVMIWMSSIIAIQIHRYRSALGAIEKQQTKWAVFGMASAIAILMAVTVFYIAQEDKLQNDPLLLFAMETLLSLGMLLIPVTLLFALLRRRLWDIDPIVNRTLVYSALSLFAVAVYVFVVWYIGVVFHSAGQWQWLNSLIATGLVAVLFAPLKDKLQRWINRLMYGENDDPLTVLGRLGPAWKIHCPPPMRLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFN0</accession>
    <name>A0A398CFN0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_22850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01235">
        <property type="protein sequence ID" value="RIE01235"/>
        <property type="gene ID" value="D3H35_22850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="225" mass="26049" checksum="D2C9718018CB4A21" modified="2018-12-05" version="1">MKLLIIEDDIAISYTIARVMRDEGYEVMECHNGEEGLHHALYGEFDLIILDIMLPKVDGFTFIQETRRRIVDTPILCLTAKDGLSDRVKGLTIGADDYVVKPFEIPELIVRVKVLLRRYGKVNQEEQLSCGPIAIQVRTRAVTVMGEELTLTEKEYELLEYLLMNKEQIVTKEQIYNRIWGLDSEAGIGIVELYVHYLRKKLSLWNADQFIRTVRGLGYRLRINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFS8</accession>
    <name>A0A398CFS8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_14880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02046">
        <property type="protein sequence ID" value="RIE02046"/>
        <property type="gene ID" value="D3H35_14880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="14"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="5">
        <location>
            <begin position="174"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="243" mass="27365" checksum="DF280D8721E24CC7" modified="2018-12-05" version="1">MEYMESKAPIAKIKVLLADDHQLFREGLKRILNMENDLEVIGECGDGIQVLEFCNRFKPDVVLLDINMPVENGVVATERLRDIFPEIKVIILSIHDDESYVFETLRKGATGYLLKDMEAESLINAIRTVAEGHAYIHPKVTGKLINQLRRMTYLDEIGATSGAAASRETVTKFIPRGNNPLTRREAEVLRLMAEGKSNKTIGEHLFISEKTVKNHVSSILQKMEVDDRTQAVINSIKCGWVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFZ8</accession>
    <name>A0A398CFZ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01420">
        <property type="protein sequence ID" value="RIE01420"/>
        <property type="gene ID" value="D3H35_23925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000310">
        <property type="entry name" value="Orn/Lys/Arg_deCO2ase_major_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01276">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OKR_DC_1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="211" mass="22892" checksum="1C9889E64837F5AA" modified="2018-12-05" version="1">MLHRAPMFEALAEHSRAGGRAFHVPGHKQRASFSHEEAAVYYDSIAALDVTELPDTDDLHHPIGSLLEAQQLAADCYGTDETRFLVGGSTAGNLAMILGQCEPGDLVIVQRNVHKSVIHGLMLAGARAVLLSPEIDPISGLGLLPHPERLDRALEQYPEARGVILTNPNYYGMTGDLAPLVRLVHERSIPVMVDEAHGPISASIRDFQALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG98</accession>
    <name>A0A398CG98_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_13195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01753">
        <property type="protein sequence ID" value="RIE01753"/>
        <property type="gene ID" value="D3H35_13195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="70" mass="8374" checksum="6E9AC166CEB99D11" modified="2018-12-05" version="1">MKLNKAALIRHMNENFNGNYAWLAWELKIDVAYVYAVLVNDKKCGELFLKSIIRWCDENNTDFREYIFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH47</accession>
    <name>A0A398CH47_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ketopantoate hydroxymethyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01292">
        <property type="protein sequence ID" value="RIE01292"/>
        <property type="gene ID" value="D3H35_23190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="94" mass="10263" checksum="2E8AC2BEFDE4D041" modified="2018-12-05" version="1">MITQSYLNEVAGYTNTKIAKVVLNGSIEITSFVIKATMDNVLTIEYLVPFGLVATVTKMELKSSAGMVISTRTVNVPIVEDTIMRHVISIEEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH82</accession>
    <name>A0A398CH82_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_13675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01835">
        <property type="protein sequence ID" value="RIE01835"/>
        <property type="gene ID" value="D3H35_13675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="22"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="223" mass="24025" checksum="89B040F0F8ECD73C" modified="2018-12-05" version="1">MGWLSDYGEFLRSRHADILTALREHVYISAVSILLGAIVAIPIGIWLAGNRRGWLNGAVFTLANVLQTIPSLALLAILIPLLGIGRTPAVFALFLYSLMPIMRNTYSGFLAVDGNVLEAARGMGYSRIQRLLRIQLPLAFPYIMSGLRVTTVYIISWATLATLIGAGGLGQLIFSGLGVNKKELIVTGALLAVLLALVADFLLGLAEKRVTARTRSKPVQNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHJ1</accession>
    <name>A0A398CHJ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF420 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02233">
        <property type="protein sequence ID" value="RIE02233"/>
        <property type="gene ID" value="D3H35_15980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007352">
        <property type="entry name" value="DUF420"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37692">
        <property type="entry name" value="PTHR37692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04238">
        <property type="entry name" value="DUF420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="154" mass="17337" checksum="7F986EBD7303C0B5" modified="2018-12-05" version="1">MSWYFIFPTVSTSFIALSAILVAIGWRQIIKRKREAHEKTMVAAAVAALLFFIIYMSRTIFIGNTSWGGPDDLKTIYLIFLLFHIVLATVAAVFGITTLTLAWRKKFAKHRKWGRTTALIWFATALTGITVYVLLYLCYPGGHTKPVIDAIFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHN4</accession>
    <name>A0A398CHN4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02293">
        <property type="protein sequence ID" value="RIE02293"/>
        <property type="gene ID" value="D3H35_16350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004792">
        <property type="entry name" value="BaiN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023166">
        <property type="entry name" value="HI0933-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42887">
        <property type="entry name" value="PTHR42887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00275">
        <property type="entry name" value="TIGR00275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="422" mass="44340" checksum="6F2884D4AC394F9D" modified="2018-12-05" version="1">MNTDVIIIGGGPSGLMAAIASARSGARTVLIDKGDKLGRKLGISGGGRCNVTNNKESAEMIRFIPGNGRFLHSVLSRFGSREITDYFEGLGIALKEEDHGRMFPASDKAKTVVDTLVREVVRSGVEIVVNRKVNKVLYGDGSVQGVRLSDGETLSSRCVVIATGGKSVPQTGSTGDGYAWAEEAGHTITELFPTEVPITSDEPWIRSRELQGLSLRDVKLTVLDGRGKPVVSHEGDMIFTHFGLSGPAALRCSGFVSTALRKGKGPVTVAIDLLPAIGERQLEDKLGAAARSDPRKAAKTLLRALLTERIVPVVLRLAEADGEADAGNVSKAAWQAIASICKALPVAANGTLSLEEAFITGGGVHLKEIDPRTMGSKQMRGLFFCGEVLDIHGYTGGYNITAAFATGRAAGSAAAEASLAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHR6</accession>
    <name>A0A398CHR6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LytR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_16580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02333">
        <property type="protein sequence ID" value="RIE02333"/>
        <property type="gene ID" value="D3H35_16580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="85"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="338" mass="37607" checksum="AD661293A2C0F6AF" modified="2018-12-05" version="1">MKKGWKVALTALLGVLVVFFCVVGWWVYQSKHQLDQMQKSKEESRFGQFETKEDEKPPEWEGTERVNILLMGGDERGLRKGEVARSDSMMVVSIDPESKKIHLFSVLRDTYVKIPGHDRNRINTALALGGPDLAMKTIGDLTGLNIQYYVYVDFQGFIKLVDAIGGVDFYVEKNMKYSDSADGHVYDIDLKKGQQHLDGEKALQYVRFRHDAMSDFTRTERQREFMKTIANKLRQGTNLVRLPDILGKVTPFVETNLSGNDMLKLASLGYKSHQAGSAQLPPMELVTDEKVGGSSVLGIKDEDALKGYVQSVLMKDEAEASASPSSSPSSSPSASAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHV4</accession>
    <name>A0A398CHV4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_14135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01915">
        <property type="protein sequence ID" value="RIE01915"/>
        <property type="gene ID" value="D3H35_14135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="138"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="335" mass="37471" checksum="5CF60844505FDCD8" modified="2018-12-05" version="1">MEIAENIRYGEARIRRKASVSLSAAVRLLLPSLSLIAVLAIHYLLPDKQPVLKSDIYAYAIEILLAVYLLWTGASFVFEGARAKLRYQAPITAFIILLIGAWELLTLKLDALPLPYFPSPVKITDALVNDREKLFICTLYSLRLLAIGYLIGAFFGVITGILMGWYKLFQYWVNPFLRFIGPVPATAWIPVVLLVFPSSFTASIFLIALGTWFPVSVMTWSGISSVNKSFFEVAKTLGATERYLVLRVALPAAFPLIFIGLFMGLGTSFVTLVVAEMLGVKAGLGFYITWAQGWAEYYKVYAALLIMAVLFSTIITVLFKVRDRVLIWQKGLIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI13</accession>
    <name>A0A398CI13_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_15070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02080">
        <property type="protein sequence ID" value="RIE02080"/>
        <property type="gene ID" value="D3H35_15070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="175"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="351" mass="40325" checksum="D160A34837FBD8A5" modified="2018-12-05" version="1">MMTMTNEPLKILSVYKWSTMGGVERVLLNRAHAFKLHRKSIVQHVYFFEDGGGLRAFKEYIATHELSDYIKVVEAFVPEYYDVILPIDTPEIFEQMSDYGKVIMECHTSYRENRQYVRKLPESIGGLIVPSKNFKNSIMDEVPLFLRDKVKLVRNCIPGLRTSSPIFSPWQKTPLAYVGRIDKLKNIEEIFQIFASAVKRFGDRFILVLAGPIINEDIDFEKMVGDYGLLGRIVYLPPVRFHKVPLLLDMLKFGKGIFLSSSKSESFGLSVAEAMAHGLPTVLSDIDAHRELVEDSRRYLYRIGDINEATDKLAELLDNYEFHSGELEQLSHRFGADAFVRDWLDALELTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CID8</accession>
    <name>A0A398CID8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Coproporphyrin III ferrochelatase</fullName>
            <ecNumber evidence="8">4.99.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hemH</name>
        <name evidence="8" type="synonym">cpfC</name>
        <name evidence="10" type="ORF">D3H35_20885</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:49572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="4.99.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:49574"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8 9">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.99.1.9" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03046">
        <property type="protein sequence ID" value="RIE03046"/>
        <property type="gene ID" value="D3H35_20885"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="PTHR11108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="3 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Fe-coproporphyrin III binding" evidence="8">
        <location>
            <begin position="51"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Fe-coproporphyrin III</name>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Fe-coproporphyrin III</name>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Fe-coproporphyrin III</name>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="317" mass="35016" checksum="863B5486D19A03E7" modified="2018-12-05" version="1">MSERGDVDNRVGVLVMSYGTPESLEGVEAYYTHIRRGHPPTAEQLEDLTSRYRSIVGGVFPLRENTNRQVKALQATLNELSGEGRFVCYQGLKHSSPFIEDGVAAMAADGIKEAVGIVLTPQYSSMSVGGYIKRAQEEAEKQGVAMTFVRHYHLHPELIDALAKRVSAGLDRFGEQRDEALVLFSAHSLPEKILELNDPYPEELLETSRAIAAAAKVGKWQFTWQSAGQTGQPWLGPDILETIDTLGREGARSLLVAPVGFVSDHLEVLYDIDLEARRFAEERGIRLERIAMLNDDPQYMRAMADSVLAALTGDKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIL5</accession>
    <name>A0A398CIL5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-directed RNA polymerase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03136">
        <property type="protein sequence ID" value="RIE03136"/>
        <property type="gene ID" value="D3H35_14745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024596">
        <property type="entry name" value="RNApol_su_b/EpuA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11772">
        <property type="entry name" value="EpuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="75" mass="8367" checksum="5DA41AACCF528320" modified="2018-12-05" version="1">MTRSSEPSGQHSTGRVALRIIWTTVKIFIIPVLCVVAIIFGLAVGYSVLGKQPLSDVFDLNTWKHMYDLVFSREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIU6</accession>
    <name>A0A398CIU6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminopeptidase P family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_18415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02653">
        <property type="protein sequence ID" value="RIE02653"/>
        <property type="gene ID" value="D3H35_18415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="2">
        <location>
            <begin position="12"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="148"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="398" mass="43464" checksum="1C8C95FF9A2590C6" modified="2018-12-05" version="1">MEKRSKDEAVIRRIRMQKEMARHGMEGCLVTQNVGLYYFTGSMQTGYLFIPKTGEPTYYVRRSLARALEESDVRTVELGAFRQFGAKLAEDYPEVFGRKPALIGADLDVMPAQLYLRLTEAVPQASWMDASAALRVVRSVKSAYEIDKISQAAEVADAALREGLSSLREGMTELELMAVIENSMRRAGHIGLMRMRGYNQEIMTGVVAAGEAAAEPSYFDGPAGGRGLSPAAPLSSSKRPIMRDEPILIDIGCCIDGYTIDQTRTAVIGELSEELLHAYETSEAIVRRTEALLKPGARPDQLYFEALNMAAEAGLSSHFMGFGGDQVRFLGHGIGLEIDEWPALAKGFSEPLEPGTVVAVEPKFTFPGIGVVGLENTYVVTETGCRALTKSPETLFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJL6</accession>
    <name>A0A398CJL6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HflC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_19955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">HflC and HflK could regulate a protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the band 7/mec-2 family. HflC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02893">
        <property type="protein sequence ID" value="RIE02893"/>
        <property type="gene ID" value="D3H35_19955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052547">
        <property type="term" value="P:regulation of peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03405">
        <property type="entry name" value="SPFH_HflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010200">
        <property type="entry name" value="HflC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42911">
        <property type="entry name" value="PTHR42911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005651">
        <property type="entry name" value="HflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="4">
        <location>
            <begin position="21"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="288" mass="32519" checksum="D623F02486304AE7" modified="2018-12-05" version="1">MSKKAIIYSVIGLAAFILLLNSFYIVKEGQYKVVLKFGEAVRVADTPGLKLKMPFVENTMTLPKQQMTYESNPTSILTKDKKPIIVDNYTVWRIEDAEKFLRTAKSVGVGIQRIDEAVYNSVRRKLSEINYDSIISENTARGNINDEITNDVSTALERDHYGIKIVDVRIKRTDLPEGNKQSVYNRMISDRQSIAARYLSEGDEESRKIMSKADRNATELMAEAEASAKKIIAEGEGQAAKIYNAAYGKDPAFYQFYRTLDSYVTTLKNEPVILMPIDSPYTKILLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJS0</accession>
    <name>A0A398CJS0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_18095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02595">
        <property type="protein sequence ID" value="RIE02595"/>
        <property type="gene ID" value="D3H35_18095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="225" mass="26415" checksum="C024574740D973CE" modified="2018-12-05" version="1">MKIFFLFGFLWWLLGNPFLALIVLLVILYALERRFIGLSPSLVRPFRRRGSIAKWKRQLELNPHDVSAKSELARLLIEGRKFAEARDVLAGMEDKMEHSAEYWSDLGTCELALGRWEEGERAMLRALDISPRVKYGQPYLKLGEAYAKKDAEKALRYLRQFKEVNSSSCEAYYRLGLVYGELGKADEAALAFQDCRKLYRTLPRYMRRHERKWALRSLFRANRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK11</accession>
    <name>A0A398CK11_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YafY family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_22640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01198">
        <property type="protein sequence ID" value="RIE01198"/>
        <property type="gene ID" value="D3H35_22640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="321" mass="36770" checksum="5E0980C46D6F9259" modified="2018-12-05" version="1">MRLERLLNIVIILINHRMVQAKELAERFEVSVRTIYRDIEALGLAGIPVVTHQGSNGGIGLAEGYRLDRHLLTDQECAAIVTALRSITSFAAGDGADSAMLMEKIRSIIPAVRQQAFQEQSSQLLVDLSPWGHYPQLEAMLSTVKRSISNQRLLRFQYHNAKGEVSERLVEPYTLLMKGRSWYLYAYCRQRNDYRLFKLQRMKDTVITEAAFTRRADAETDNPTLVVKQWYTPENTTDVVLRFTDQARHLAEEWFGISSLESETVGEVRKWRATARFPEDSWLYGFILSFGSEVEVLEPAHIRNIIRQSAQRVADIYSGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK99</accession>
    <name>A0A398CK99_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_18965</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02730">
        <property type="protein sequence ID" value="RIE02730"/>
        <property type="gene ID" value="D3H35_18965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43697">
        <property type="entry name" value="PTHR43697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="140"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE02730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="428" mass="49100" checksum="B0EEC4965F99D67D" modified="2018-12-05" version="1">MLDIRYIRDNGELLQRTADKKGIDVSIRELLELDVRRRRLRQEADELRRERNRLSEEIGRWLRSGEHNRGEEAKRTVNGMNERLDVCEKELEEVEAPYERLMQLVPNPVSEQTPDGRSDEDNVEIKRVGELPAFDFEPKDHVQLGEELGILDIPRAVKLAGTRNYALKGVGFHLHRAVQQLALDVLDKRGYVPMDVPMLARGEAFKHTGFFPLGRDQTFAIEGEDRYLIGTSEVSLVSYYANEIIDLTEPVRLAAASSCFRSEIGSAGRDVRGLYRVHQFAKVEQVVFCANDPELSERMLQEMTANAEEVLRLLELPYRVVSVCIGDMSQKTHKQYDIETWMPSRQAYGETHSSSNLHDFQARRANIRYRDNNGKLQYCHTLNNTAVATPRILIPLLENHQREDGSVYVPKALRPYMGGLEEIRAPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKK8</accession>
    <name>A0A398CKK8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pstC</name>
        <name evidence="11" type="ORF">D3H35_20030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02905">
        <property type="protein sequence ID" value="RIE02905"/>
        <property type="gene ID" value="D3H35_20030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="98"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE02905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="319" mass="34900" checksum="CB2510C276F57DBB" modified="2018-12-05" version="1">MLNQAQASPIVAPGELGRSIKSGSGKTLDRKNRLLFYNKTFKIVCIASAVFVCLILFSILFFMFRTGILTFRDVPVQTFFLSKEWSPENETYGAFIFIFGTFALTALTLLISVPISIFVSVFLAEMAPKWLRNLLRPILDLLVGIPSVVYGFLGLTLLIPLLRDVTGTVMGDGILAAGIVLSIMVLPTISRISDDAISVVPQKFRDASYALGATRFQTIVKVVIPSAKSGILYGIILGMARAIGETMAVVMVIGNTPQLADALFKPTSVLTSNIVMQIPNVPFDSTWNYALYMMGFILLVISLIMIVFVRLLQKRGAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKL6</accession>
    <name>A0A398CKL6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01418">
        <property type="protein sequence ID" value="RIE01418"/>
        <property type="gene ID" value="D3H35_23915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="491" mass="54559" checksum="12B5DC82C4393EE6" modified="2018-12-05" version="1">MFKRLLKIDDWRKPIAWFFGIAGAALLIWLLMIPPVIGVADNGDFNRVMGASGIAPLNGKETYEDHYFAFSHARFGYGDFHSGGYVSTHVILVAAIGLIARIFNGLVFDIRWLGAAYIGLFLAAVILLVRYVPVPKGARRWGGFAVAVVLGTALLFVFADVGYSAYYQSFFGEPFAMLAMLLATAAAFALASRDRPSGGLLTLFIVASLALASSKIQNAPLGFAFALLGWRMFGISGNRRWHRQVLIGIAVLVAGATIMLVAAPDKLRHINLYQSIFYGVLKDSPHVAEDMRELRIPEKYRVNAGTNFFQHDTAIPQNDPTLRKEVLETLSHKDIAMYYLRHPSRFIQKLERASDNAVFVRPYYLGNYDKTAGKPRGQISYAYSGWSEWKAKHIPRYFGWFAGFIGLYMAAIAVWRFRTVSLRQKFMAETLAAVAIIGVFAACIPLIGDGEADLSKHLFMFNVCFDMMVVSAVTALAFFLVKLTAPRRVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKR3</accession>
    <name>A0A398CKR3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2232 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01468">
        <property type="protein sequence ID" value="RIE01468"/>
        <property type="gene ID" value="D3H35_24240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018710">
        <property type="entry name" value="DUF2232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09991">
        <property type="entry name" value="DUF2232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="301" mass="33125" checksum="5A2A862D40C8F640" modified="2018-12-05" version="1">MTSLKAGWKSLAWSAAALVLLLSLATPFSVITLFLLMVPFVVLFTALKPGAFVLHLIPVFVLAFLLLGGYGAIAATLGFFFLIPSIAMGYRYKKGASARSALVLGSIVILAQLLIEFTIFSIQFKLDLAAELASAMDTMLQRLQTGTLLPSNWTSDMADSIVKGLPMLLLLSSFLFALIAHGLSRWALRSFGIQANALPEARTWRLPRSLVFYYLIALVASFFISADATGFWPVVVSNLVPLLQYAFIAQAIGFFFFLAHEKQWPKAVPILIAIPLILFPPLYLIGLIDAVFPLRRYFVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKR9</accession>
    <name>A0A398CKR9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_13460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01799">
        <property type="protein sequence ID" value="RIE01799"/>
        <property type="gene ID" value="D3H35_13460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="22"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="328" mass="36813" checksum="9158D26033071B28" modified="2018-12-05" version="1">MIEVSGMSKHYRIVKKQPGLSGAVKGLFSREYTVKKAVDDISFQIKPGEMVGYIGANGAGKSTTIKMLCGILTPSSGEVRVGGIVPYKERKRNAKNIGAVFGQRTQLFWDIAVRESYDLLKHIYEIPDKEYRETIAMFTEVLQLEPLLGVPVRQLSLGQKMRCELAAAFLHSPSIVFLDEPTIGLDVAVKVKIREFIKKMNQARGTTVILTTHDMQDIEEICNRIIIIDEGKVLYDGSLQSIKDQFGHKRVIHFELDQEGLFALPERLSNQAEFSQEEDGIVSVSFSNQAITAADVITEVMKDYRIRDLTIADPKIETIVQEIYEKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKU8</accession>
    <name>A0A398CKU8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03936">
        <property type="protein sequence ID" value="RIE03936"/>
        <property type="gene ID" value="D3H35_08200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017312812" evidence="1">
        <location>
            <begin position="28"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="302" mass="33695" checksum="BAAC237DAD8D947E" modified="2018-12-05" version="1">MKTNNKWVVVSLCFGIVFSSFSGITFGSDKKEVSLDINQPSKQLAVPPDTAKPADTTIEIKGDSPDNFEPLFSGSLEQLGGNSAIDPYSIDADQLEKFLNEGYGLEDIFRADEIGNQVGIDPEEVLHAKTDGADWEDVQSKLLDEKQSRLEQELRKQFSSEYNALRSFKLTEEEKSLLLLAKQENRELNITDVARAYQQQGKKAISDAINQVKTQDTAPEINVLPDQEAESQEGLTKDSLGKKQVISDKENSVEVNDLPPLLVEKLKAFAEANQIPLEELLQQYKDEKNRQSAAVKMTTEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL16</accession>
    <name>A0A398CL16_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01929">
        <property type="protein sequence ID" value="RIE01929"/>
        <property type="gene ID" value="D3H35_14235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="46"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="286" mass="30814" checksum="FF074B7BA39DDAC0" modified="2018-12-05" version="1">MKKWWIIGGLLLIAIGIAGIATGGWKTNEKLPEFEKSWRFQASELKNLEIKSDYKVNLKFVKSTDGTNSVSVKGQAPEKTIQTVQDAVIDNKSLLVDLRQKPVKYFNFLDFSFVGVKEEITVSLTDDAALDALKVNVDSGSIALTDVSAKTVDLSADSGNLTLNNLTADSLSIDVDSGKITGDGVRTKTLTLSADSGLVNLKRVTGKVDMIIDSGSVKLYKEDTSDTVIKADSGSVYVQVPASFAGYYDLKADSGSVHAPESKRETKDIVKVRADSGLIRVEQAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL21</accession>
    <name>A0A398CL21_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000058">
        <property type="protein sequence ID" value="RIE00321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00321">
        <property type="protein sequence ID" value="RIE00321"/>
        <property type="gene ID" value="D3H35_29195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="190" mass="22086" checksum="62715FC5EB930540" modified="2018-12-05" version="1">MTAYPLANREPYWKFVVGLNTESGGVWNAADGKHMRQFKLGEERNREERRVVIERLSNVDALPSLFARKFVSFWGGPDSSAFWSMEKLNMPKQTERVNKLERAVYAAMCFFGAIGLLALVRDRQYEWHRLFLILLFGYAAIHLFIEIQGRYRLDMIPILVLLQSYGVYAAYSRITLWLSPRADRDQGVPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL60</accession>
    <name>A0A398CL60_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_20260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02942">
        <property type="protein sequence ID" value="RIE02942"/>
        <property type="gene ID" value="D3H35_20260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="217" mass="24341" checksum="6AB72D93F70122A7" modified="2018-12-05" version="1">MGVISRLHHGLIFRIFLRVGVRSSGVVIFVFRFPALKSLRVGSFIRFHLLVLDELPRGIPGHVRRPDVKIPSSAAFGRQSACRRLDIIRLVVDHAKRHVIARIQSVSGLLGSQGKPLDRSEVVLFLAGKRILRIPAPSVVDEPHFRRSSRSRSGHIVRTIDSFARPRGYALIRVERRNFKRRIVGVDCDFAVFGVCVAGDACRGISEPDLWKRVVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLS2</accession>
    <name>A0A398CLS2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium-transporting ATPase KdpC subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP phosphohydrolase [potassium-transporting] C chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-binding and translocating subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-translocating ATPase C chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">kdpC</name>
        <name evidence="12" type="ORF">D3H35_15600</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the KdpC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02169">
        <property type="protein sequence ID" value="RIE02169"/>
        <property type="gene ID" value="D3H35_15600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00276">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003820">
        <property type="entry name" value="KdpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042">
        <property type="entry name" value="PTHR30042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02669">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001296">
        <property type="entry name" value="K_ATPase_KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00681">
        <property type="entry name" value="kdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE02169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="201" mass="21448" checksum="39B811F335484CA0" modified="2018-12-05" version="1">MLMHATSEKPSEGSSLLITVRAAIVFIVLCGIVYPLACTGLAQALMPGHANGSLIEDAAGKTVGSELIGQTFTDPKYFQGRVSSIDNKAEASGSNNYAPSNPDMLKRTKDSIEAWQTANPDVPIGKLPIALITNSGSGLDPHITPQSAEVQIPRISKLTGIAAADLEKLVDKHTEGRDLGLFGEPRVNVLRLNIDLQTWFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLU2</accession>
    <name>A0A398CLU2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1987 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03212">
        <property type="protein sequence ID" value="RIE03212"/>
        <property type="gene ID" value="D3H35_19890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018530">
        <property type="entry name" value="SiaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09345">
        <property type="entry name" value="SiaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SiaC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="129" mass="14990" checksum="4C6061D27B94DA05" modified="2018-12-05" version="1">MEQMTLSPSRSTPEVRFDPEANVLAIRGQSYPENAFAFYEPLLKWVDLYLLQLNSDSRVEIELQLPYINTTSTKCFVMLLEKLDQAHLAGKKIEVLWYYDEENESELECAEDFKEDLSLPFHILPKAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLX4</accession>
    <name>A0A398CLX4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_15895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02219">
        <property type="protein sequence ID" value="RIE02219"/>
        <property type="gene ID" value="D3H35_15895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="116" mass="12550" checksum="49190ECB2D9B9A8D" modified="2018-12-05" version="1">MQLPFEGTGFRLVSAVSVWGYSIAIGSILLLLGGMIAVIRASSDDSGKFSELRQMVEAMFGTPAHLRPGSDDETESSRQTAAGKSYEPFEDRCPACQITVTHEHQNCPSCGLRLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM02</accession>
    <name>A0A398CM02_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000043">
        <property type="protein sequence ID" value="RIE00887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00887">
        <property type="protein sequence ID" value="RIE00887"/>
        <property type="gene ID" value="D3H35_25875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="70" mass="8143" checksum="5DE50217B8895DDD" modified="2018-12-05" version="1">MLKYSLKKPVTAGKKRDLARMRYGRPHPQTMVRIGNAGQIPLFGRRDRFFKEYLSIREEAVDKQGDYASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM17</accession>
    <name>A0A398CM17_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Flagellar protein FliL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_11420</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Controls the rotational direction of flagella during chemotaxis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the FliL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03292">
        <property type="protein sequence ID" value="RIE03292"/>
        <property type="gene ID" value="D3H35_11420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005503">
        <property type="entry name" value="FliL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35091">
        <property type="entry name" value="PTHR35091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03748">
        <property type="entry name" value="FliL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017374213" description="Flagellar protein FliL" evidence="9">
        <location>
            <begin position="35"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="159" mass="17660" checksum="1A9138BB426176C7" modified="2018-12-05" version="1">MKKMLPWLVSLLLAITLIVIVALYFWSSLFGSDAKDPEDQARESVQSVAAEPMSADEMIKVTSELTNIQTNIADTDYVVRISLSFQMDSAKAKEEFDKIKDIQVKPLINRALWVLNSEDVKGTKGKDQLCAELINAINPVLSEGKLTSVKITDFIISPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMJ7</accession>
    <name>A0A398CMJ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_09780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03833">
        <property type="protein sequence ID" value="RIE03833"/>
        <property type="gene ID" value="D3H35_09780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="306" mass="33758" checksum="2EE759845554480D" modified="2018-12-05" version="1">MTQGPIVRLTNVTKRIGNRTLIDRVSLDVHAGEVFGFLGPNGSGKTTTIRMMVGLTRINEGDIQIAGHSIRTEYAKAIVNVGAIVENPEMYKFLTGYQNLLHFARMNPAVTRKRIDEAIELVGLQGRIHDKVRKYSLGMRQRLGVAQAIMHRPKLLILDEPTNGLDPAGIRELRDYLRRLSREEGTAVFVSSHLLSEMELMCDRVAILQNGKIIDTRSLRGEEETVRAADIVQFDVDHPDAALGILEGAGSARIVDGLLTFEADRGTVASVNRKLVEAGINVYAIRVKTKSLEDQFLEMTGGESVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMQ4</accession>
    <name>A0A398CMQ4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03745">
        <property type="protein sequence ID" value="RIE03745"/>
        <property type="gene ID" value="D3H35_09310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="185" mass="20592" checksum="955BD7F7E16DBF89" modified="2018-12-05" version="1">MLLSTLIFPFIWDGSNEADVPIRDRLSNQFTVGRALATANLTPWGKLFKAGKIAMLLVKVGSKGEDVVTGFRTFDELKKVLGSAGENKAWYHIVEQSQVAKYGFSVGDIQNLNNVVAIPSGYSGSVHSKISGFYSSKQPFTNGKTVREWLSGKSFEYQFEFGLQQLKKYGTVEQTSNGWVFKLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN03</accession>
    <name>A0A398CN03_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">groES</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="5" type="ORF">D3H35_25715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00961">
        <property type="protein sequence ID" value="RIE00961"/>
        <property type="gene ID" value="D3H35_25715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="94" mass="10114" checksum="C73203B2546F1484" modified="2018-12-05" version="1">MIRPLGDRVLVEAVAKEEKTASGIVLPDTAKEKPQEGKIVAVGSGSVNKDGVRVALEVKEGDVVLFSKYAGTEIKYEGKEYLIMKESDIHAIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN05</accession>
    <name>A0A398CN05_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000034">
        <property type="protein sequence ID" value="RIE03620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03620">
        <property type="protein sequence ID" value="RIE03620"/>
        <property type="gene ID" value="D3H35_10620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="357" mass="39661" checksum="DDDDF2A44ACC7EA9" modified="2018-12-05" version="1">MTPVEGADGTDGEDGGDFSLFIETAAADSPHFQMNASGGKGGDGKAGLSSDTKGGDGGNGGCGGNVKLLYGHPYLKLVAELRNIYQDEDEDDKVKKLIGILEENPDVALLEPFRQKLKDSASPETADVVIQEMTSRLIVLADGWKSQALASTDVSGGMYGTYGEGVVNGNNGKSGERGMFHIMPVGSAAQLANMQEEFFFPWIHPVQCQMLFEKARLRYFCLEPSDREAVAETMVYFKRLQQKTSPFEHMQAGSTLEKLWSKYEQRIAAAGSVPIFKDLHRKTVLYLDRLSQGLDYYGYKYNHVPVVSFDFCREQLDALIANFKTIQEEYALQLEALQDVTERNLRWPRPDARRSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN54</accession>
    <name>A0A398CN54_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zn_Tnp_IS1595 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04786">
        <property type="protein sequence ID" value="RIE04786"/>
        <property type="gene ID" value="D3H35_04740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024442">
        <property type="entry name" value="Transposase_Zn_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12760">
        <property type="entry name" value="Zn_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_Tnp_IS1595" evidence="1">
        <location>
            <begin position="16"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="77" mass="8945" checksum="FFA746954BFFFBE7" modified="2018-12-05" version="1">MLDHSTFESFCHQYSSEQACAEALFHARWPDGFRCPTCRHPHYYLTRTRRLPLYECRSCRVQTSVIAGTIMEGSSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN92</accession>
    <name>A0A398CN92_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03772">
        <property type="protein sequence ID" value="RIE03772"/>
        <property type="gene ID" value="D3H35_09470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BIG2" evidence="1">
        <location>
            <begin position="54"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="1">
        <location>
            <begin position="140"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="1">
        <location>
            <begin position="230"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="1">
        <location>
            <begin position="409"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="1">
        <location>
            <begin position="584"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="1">
        <location>
            <begin position="668"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="752" mass="77665" checksum="20D0238288690112" modified="2018-12-05" version="1">MKSTNVTLQTGTKPSVTRRSSFLTRFLASFLVAVLIGGSGAAYVSAEDTVESIAFGAVSSNPVQLSVEDGTKSLTLWANFKETSTPQNVTSLATWASSSSLVKVDKGVLSATGAVSGVSITAKYKTFSASIIVDASYSLSELQLEVDGANAGVGRTVWLGDELTLTAVNADTSEDVSEDAVWTSSSASVATVENGEVTLVAAGTTKITAKYKGRSDSVTLTVKAPYSEISIVSPKIESGIVDLNVGDDPVQFSLSAVRTDDDSTESDLETKAAWTSSNSAVVKVDKNGLATAVGSGTATVTATLNGVKDAVTFYVLTPYEAMKLASEKPLNLSFNAEPVKVTASVVKGSAQAEDKTAQAEWKSGNLLVASVGTDAAGVVTVKPRGVGTTQITASYLGVSKSLTVTVFPTIESVDVVPDKLDAFEGDTVELPQVNGVAVSGDPVDLTKLVQWKSGSETVLTVDETGKWKALKAGTATLLALVENEEGQVKTDQIEVTVHKKIHSLYADTTNISIVTGTEAAFPAVTVIYADGEEKVITSEVTWKSSSTNLLVKATKIKGLQPATATLTGTYLGKTVSIKTVVEEKFQTIKVEPSSLALGLKASQTIKVTATTVSGKKVSIGSRITWIPSSEELISIKGASVKGLAEGSGKLTATIQGKALEIPFTVAAKLTKLTASPTSLKLTSGASGTVKVTATYENGKTVDVTSAVSWSNSNGNVAKVTGGTVLAIAKGSATLKGSFGGKNVTVRVTVKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN94</accession>
    <name>A0A398CN94_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrG</name>
        <name evidence="12" type="ORF">D3H35_21670</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01051">
        <property type="protein sequence ID" value="RIE01051"/>
        <property type="gene ID" value="D3H35_21670"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="3"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="302"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="382"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="148"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="188"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="240"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE01051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="534" mass="59187" checksum="4705805A0BABC914" modified="2018-12-05" version="1">MTKYIFVTGGVVSSLGKGITAASLGRLLKNRGLKVTIQKFDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLSKNSNVTTGKIYSTVISKERRGEYLGGTVQVIPHITNEIKDRVFRAGREAGSDVVITEIGGTVGDIESLPFLEAIRQIKSDIGRDNVMYIHVTLIPYIKAAGEVKTKPTQHSVKELRSIGIQPNVIVCRTEYPLAEDLKRKIALFCDIDAGAVVECRDASTLYEVPLMLREQGLDDYVCKHLGLPDTTPDMEEWRALVHRVKSLSKTTEIAIVGKYVALHDAYLSIVESLGHAGIHADSQVKLRWVNAEEITPSNVGELLGGVNGILVPGGFGDRGIEGKITAIRYAREKEVPFFGICLGMQVAVIEYARSMAGLDGANSSEIHPATPYPVIDLLPEQKDIEDLGGTMRLGLYPCKVVPGSLAAQCYGDELVYERHRHRYEFNNEFRERIESAGLRISGSSPDGRLVEMIELPDHPWFLAVQFHPEFTSRPNRPQPLFREFVKASLNHKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNB9</accession>
    <name>A0A398CNB9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gluconokinase</fullName>
            <ecNumber evidence="4">2.7.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gntK</name>
        <name evidence="4" type="ORF">D3H35_10125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03730">
        <property type="protein sequence ID" value="RIE03730"/>
        <property type="gene ID" value="D3H35_10125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006002">
        <property type="entry name" value="Gluconate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01314">
        <property type="entry name" value="gntK_FGGY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="254"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="510" mass="55649" checksum="756B5F450D53BF3B" modified="2018-12-05" version="1">MIGIDIGTTSTKAVLYLEDGAVVATANNEYPLYTPAPSVAEQDPDEILAAAVRSVKQVMDKSGVPPERVMFVSCSSAMHSVIPVSGDGKPLMRCLTWADNRSAEWTNNLKADMGGHSIYLRTGTPIHPMSPLSKLLWLRNDRPDVFRDAVKFVSIKEYVLFKLFGEYVIDHSIASATGLFNLNALDWDEEALSVAGVGPERLSRLVPTTYRLDGLDSRYAAEMGLSPSTPFVVGASDGVLSNLGVDAVDPGVVAVTIGTSGAIRTVVDKPITDPKGRYFCYALANSKWVIGGPVNNGGVIFRWVKEEFAASETETALRLGISPYDVLTKIAERVRPGSDGLLFHPYLTGERAPLWNPDARGSFFGLTLHHRKEHMIRSVLEGVIYNLYAVNLAMQETIGVPRKIMATGGFARSPLWRQMMADIFGQTVVIPESFESSCLGAVVLGLYAFGKTDSLSGAVAGMVGTTHEHAPNPESAAIYRELLPIYVRLSRKLEEEYEHIAKFQEKYSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNC0</accession>
    <name>A0A398CNC0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-3-methyladenine glycosylase 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03985">
        <property type="protein sequence ID" value="RIE03985"/>
        <property type="gene ID" value="D3H35_08485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="53"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="205" mass="22940" checksum="5D9D922806B65DDF" modified="2018-12-05" version="1">MTAVVTKFFAYGEEEMAYLSNADPILGAAMARMGKIERGVIPDPFAALVHAIVGQLISAKAVRTIWERMHIRLGEITPKNLAAKSADEIQSCGITMNKAICIASIARKISDGLFDLQQLRELTDDEVVRKLSSLDGIGKWTAEMMLIHALERRDVVSWGDMAIRRGMMKLYGLTELTKKQFDRYRASYAPYGSVASIYLWELSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNC7</accession>
    <name>A0A398CNC7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SIS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03995">
        <property type="protein sequence ID" value="RIE03995"/>
        <property type="gene ID" value="D3H35_08535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05006">
        <property type="entry name" value="SIS_GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035461">
        <property type="entry name" value="GmhA/DiaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="42"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="201" mass="22166" checksum="F79B8C9997CAAC92" modified="2018-12-05" version="1">MSGIVKQVGYDFKVEISDYLSGLKEVLDRLDLNEINTVISKLIEVNQRQGFIYIFGNGGSASTASHFVNDFNKGVSEKLGKKFRFVCLNDSVSTIMAIANDVSYDQIFKIQLENYLTPNDVVIGISGSGNSKNVLAAIEYANSVGAETIGLVGYNGGKLKQIASASIHVPIDDMQKVEDVHMIMDHLMMFILKDYLERWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNE4</accession>
    <name>A0A398CNE4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NifU family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02769">
        <property type="protein sequence ID" value="RIE02769"/>
        <property type="gene ID" value="D3H35_19210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU" evidence="1">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="82" mass="8997" checksum="250F9F8CBCDE9B23" modified="2018-12-05" version="1">MSDNVQSTTQYDEVLDVLDKLRPFLQRDGGDVELVEVEDGIVKLRLMGACGSCPSSTITLKAGIERALLEEVEGIQEVVQVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNS3</accession>
    <name>A0A398CNS3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_24785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01567">
        <property type="protein sequence ID" value="RIE01567"/>
        <property type="gene ID" value="D3H35_24785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="326" mass="34612" checksum="B913CD1815F1F276" modified="2018-12-05" version="1">MEPRANSQEAPFAVGVDVGGTKIHAGVINRQGDVIAEHYLPTLVHQQDVISRIIEAIECVVQKAGPAFQGTPFKGIGIGTAGQIHWETGTVQYGLDLIPGYTGTPIKSILEQKFSLPVYVDNDVNVLALTEKYFGIGSKARHMLCLALGTGVGGAVVIDGKLVHGSWGAAGEIGHMSVNYKGPTCICGGIGCLELYASGTGIARMMQELQERKGIAGNPIPIESKEVVRRWLQGDSDSTQIMDEVIMALGAGISSLIHILNPDAIVIGGGVAEIGEPLFGPLRDEVAKRTMPSLHKDVWIGPACMRNRSGMIGAGLQAWEYESFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNT1</accession>
    <name>A0A398CNT1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_22830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01231">
        <property type="protein sequence ID" value="RIE01231"/>
        <property type="gene ID" value="D3H35_22830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="90"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE01231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="309" mass="34507" checksum="863AD474D89C0482" modified="2018-12-05" version="1">MGEKTYRFVSRPYQGNLPKIEKLSDTPLKTVQIITEISAEVYYLNRLLWSVGIGIGVGALLSIIAGYALARRALIPIQKAWDKQQQFIADASHELRSPLSVVQGQTQLLLRHPDHTIEEESVPISAILKETKRMSNMVSGLLLLARGDSHEEVIICKPVRVDGIIKEIAQNMEPIMDYKQLRLQLHVEGTEFLINGAEDRLIQLFMILMDNAIKFTPEHGQIDLECVRQGKSVVVTVKDNGAGISERDLPLVFDRFYKGDSARDRGDHGAGLGLSIARWIVDQHQGSVHISSEVGHGTSVTIRFPMLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNY6</accession>
    <name>A0A398CNY6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase_M28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_20575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02999">
        <property type="protein sequence ID" value="RIE02999"/>
        <property type="gene ID" value="D3H35_20575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017199310" description="Peptidase_M28 domain-containing protein" evidence="2">
        <location>
            <begin position="34"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="3">
        <location>
            <begin position="108"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="559" mass="61375" checksum="69DDA8896ED9BC6B" modified="2018-12-05" version="1">MNFMEKKTKFRGTAILAYAASILAVMIAVTASAPSVKVARKDAPAAEFSAERVYEHLQMFAQQPRHPGTAYHEQAKTYILDTIRGMDVPVEVESSVVTHEKKELPIHNIVAKLEGTEAGKEIVLMAHYDSVEEGPGVNDDAVNVGVLLETMRLLKQEKPLKNPVTFLLTDGEETGLYGAKAYVKKHSTDRIAVVVNLEARGYKGPIVLFETIGPNGRAIQLFDEHVDHPYAFSFLADLYRILPHDTDMTVFKQSGGVIGLNLAYMEGAQVYHTAKDDLQHVHLPTVQNSGLHAAALAKALGSSDLSALGNEGNRVYFNLFGHVLVQYPVSWNYAFGAIAFLLGALVMAIGIKKKTVQPRKSVRWALFVACCAVLLLTFGTIYSIGIAVYEFNGLSAALLMYTAVAALLSAAVVWILKKFKVFYRMRKLVHGLTYLDISVGALLVMAVLTAWTTIALPGSQYLTALPLALCSLNLLGYFLFRRWLTASFSFSLSIGAAFTLLLFPAIQLLTIGFGIAGIHYLLIALLLYVPLVWPPFLNENFDVSSNAEHGYPEMRITNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNZ3</accession>
    <name>A0A398CNZ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YheC/YheD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03920">
        <property type="protein sequence ID" value="RIE03920"/>
        <property type="gene ID" value="D3H35_08115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026838">
        <property type="entry name" value="YheC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38437">
        <property type="entry name" value="PTHR38437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14398">
        <property type="entry name" value="ATPgrasp_YheCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="407" mass="45344" checksum="ECCC59AFABF57FE4" modified="2018-12-05" version="1">MKRRENPSFGADDDSICPSFIRILTPSSARLTKRQRSAYSYAKKNALPPFAESRFIRKLGEHGSRQGLSVFAFAPWTWNPADGTVQGWRFEPSLLKWQREAHPLPALVYDRSWPANESEKRKYRQALRKLNSARRLAHLNGPLPGKAAVQLALAGDERLSPYLPPTRLYEGTDSFLRWLTRNRGAAFLKPAAGSQGRRVVAVRRKADGSVSLRGRLADNRAFSCDCADFHEAAARIGRWIGGREYVMQPLLDLRNAKDEPFDIRALVQKNGKGRWALTGTAIRRGQAETVTANLHGGGTAEPAQAALASMFGGEKAVMLLEEIRECCLHVVCTLEQCYGRFAELGLDFGVDRSGRLWFLEANSKPGRAAMECFGEAVARTAAGRPVSYARHILFRSPGRVIHEFDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP00</accession>
    <name>A0A398CP00_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Flagellar motor protein MotB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_23010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MotB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01261">
        <property type="protein sequence ID" value="RIE01261"/>
        <property type="gene ID" value="D3H35_23010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025713">
        <property type="entry name" value="MotB_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13677">
        <property type="entry name" value="MotB_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="8">
        <location>
            <begin position="132"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="277" mass="31308" checksum="6CBD80BEC727E039" modified="2018-12-05" version="1">MSRKHRHEPHEEHADESWLLPYSDLMTLLLALFIVLYAASSVNTTKLEELSKAFKSAFSSGISIFDKATLVETGTVMDTRDDIRHRTNDGKKKSKDQLMQEEQQNLEKLKQQLDQYIKKNGLSSQLNTQLNQSQLLITIRDNALFPSGSAAIKPESQKLAVAIGQMLQQYPDYEVLVTGHTDDQPINTLEFPSNWELSSKRAINFMKILLQNPAFDPKKFSATGYGEYRPVDKSDSDTARSKNRRVEVSILRKYTDPASDENTKTLSAIANEGKVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP23</accession>
    <name>A0A398CP23_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">ftsZ</name>
        <name evidence="10" type="ORF">D3H35_06520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FtsZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04265">
        <property type="protein sequence ID" value="RIE04265"/>
        <property type="gene ID" value="D3H35_06520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 6 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="8">
        <location>
            <begin position="13"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="9">
        <location>
            <begin position="207"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="318"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="21"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="377" mass="39912" checksum="47947E44498045A3" modified="2018-12-05" version="1">MLEFDMEMEPLAKIKVIGVGGGGSNAVNRMIENGVKNVEFITVNTDAQALQLTKSEQKLQIGDKLTRGLGAGANPDVGKKAAEESREFITNALKGSDMVFVTAGMGGGTGTGAAPVIAELAKESGALTVGVVTRPFTFEGRKRFSQAEIGIEALKEKVDTLIVIPNDRLLEIVDKKTPMLEAFRIADNVLREAVQGISDLIAVPGLINLDFADVKTIMTERGSALMGIGMATGENRASDAARKAIHSPLLETSIDGARGVIMNITGGSNLSLYEVNEAAEIVIAACDPEVNMIFGAIIDDDLKEEIKVTVIATGFEHKTTSRRPAAPAAPATTASPNPEAASEVRSAGNLRPFGSQNLSSDQLDIPAFLRNRPRNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP66</accession>
    <name>A0A398CP66_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Germination protease</fullName>
            <ecNumber evidence="1">3.4.24.78</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GPR endopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Germination proteinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Spore protease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpr</name>
        <name evidence="2" type="ORF">D3H35_05980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Initiates the rapid degradation of small, acid-soluble proteins during spore germination.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endopeptidase action with P4 Glu or Asp, P1 preferably Glu &gt; Asp, P1' hydrophobic and P2' Ala.</text>
            <dbReference type="EC" id="3.4.24.78"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Autoproteolytically processed. The inactive tetrameric zymogen termed p46 autoprocesses to a smaller form termed p41, which is active only during spore germination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.78" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04172">
        <property type="protein sequence ID" value="RIE04172"/>
        <property type="gene ID" value="D3H35_05980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00626">
        <property type="entry name" value="Germination_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005080">
        <property type="entry name" value="Peptidase_A25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03418">
        <property type="entry name" value="Peptidase_A25"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019549">
        <property type="entry name" value="Peptidase_A25"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01441">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5017490844" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023402587" description="Germination protease" evidence="1">
        <location>
            <begin position="14"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="333" mass="35343" checksum="F2241F581C92629A" modified="2018-12-05" version="1">MASDLSLYNVRTDLALEAKELATPPGGGDLPGVWSEEESGGGITVSRMHIQTEEGAQKIGKMIGHYVTLDVPELRRGDTDLQDKVATAFAKEFEAFLSRIGIDKTKSVLVVGLGNSNVTPDALGPLVVENIMVTRQFFELMPDQVSPGYRPVSAVAPGVLGTTGIESSDIVFGIAQKSSPDLIIAVDALAAKSLERVNTTIQIADTGIHPGSGIGNKRRGLTKDILGVPVIGIGVPTVVYASTIVNNTMDLVFGHMKKHTEKTGALFGVFGDMQENERLGLVKEVLQPLGHDLLVTPKEIDKFIEDIANVIASGLNAALHEAVDTDNVAAFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPF7</accession>
    <name>A0A398CPF7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_07415</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04405">
        <property type="protein sequence ID" value="RIE04405"/>
        <property type="gene ID" value="D3H35_07415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="589"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1651"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2713"/>
            <end position="2788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="624"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1686"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="3009" mass="333192" checksum="8FEDE8A808975FB8" modified="2018-12-05" version="1">MTIRNLAQLLFSDRTEGKGITFIRSASEQSTVSYRDLHREASLLLRHMQEAGLKPGNELVFQIEQNRVFLTWFWACMLGGIVPVPLTPGGSEENKKKLTSVWKKLNRPYLVAEADFWSRHSAESGGPGDEFGALLAEIGSERSLVAEWSELSGEPGQLHESSPEDIAFIQFSSGSTGEPKGVTLTHANLLANMRAIVECSGATGLDSSLSWMPMTHDMGLIGFHLTPIMAGMNQYLMLPALFIQHPTLWLNKANEHRITTLASPNFGYKHFLAHYKREQAKNWDLSSVRLIFNGAEPISASLCRQFLNEMNEYGLRSNVMFPVYGMAEASLAVTFPPAGEPLIDVEVERGSRTGQPVREHVRDENGDGKGDGERRPTVTYVDLGSSVTDCEVRICGEQDEPFSEGVIGEIHIRGRNVTRGYYNDEEATKRAFAEDGWLRTGDLGFMRGGRLVVTGRKKDVLFVNGQNVYPHDLEALLEEDEGGQLRRVAVCGVFNERLQSDEMIVFVLFRGKLQTFVPVAEQAERLIRKHAGFDVGAVLPVRQIPKTTSGKLQRYLLAQRFADGEFAREQRELEELRRTASSESRTVEWSEDELERDLQKMGMEALGTASLGVDDSFFENGGNSLKAALFVAAVQERLGVEIPIRELYGKDTVRELAGLIREAEPVERPNATAIKPAERREHYPLSEAQYRIYAQEQQEGIGACYNVPAALRIDGPFRLQEAERAFSELIGRHESLRTSFHLIEGEIAQRIDPGPVRFAVESIEADEGELPGLIVGFIRPFDLTAAPLFRARTIRLAEDRHVLLIDAHHAICDGISLTVLMEEFAELYVGKTLPSPGIAYIDYAAWYEGEKKEARSEKHRSYWSERLKGLPVLQMPTDYPRPGKRTFEGDAVFFELPEGAAYRIVKLAETRKISLYAAFLSVYFVLLHKYGAQRDIVVGSLLAGRDKPEVRRTVGMFNRFLPIRAEIPEEADFETFMLRVNDELMDAFDHQRFPIDDIAADAGAARDRSRNPLYDTMLILHNQMDGKVRFDAGGARFSRIDVHSGTSKLDFKLDLFPGENGRLDAVLEYNSSLFKRETMELFAERYARLLEAAAADPRKPIEELELLTEEERELLLTGFNDTHAAYRNDVLLHELIEEQAARTPDKIAFAFGDRKLTYRELNGQANRLARTLRAKGVGPESVVAVAMERSEEMMTALLAVLKAGGAYMPLSPDVPAERAAYMLGDSGARLALTQSGFAAEFAAKLAGTGSELLDVTEALLAGSTTSLDSETSLERLGTSRSPAYIIYTSGSTGLPKGVMVEHYSVVNRLNWMQKAYPLTERDVILQKTPYTFDVSVWELFWWGTVGASVLFLEPGGEKEPEAIVRAIEAGGATTIHFVPSMLSAFLDAVEGRPEQIRRLSGLRQVFASGEALTAKQANRFRALLHEANGTRLINLYGPTEATVDVTHFDCTAHERLETVPIGRPIDNTRLYIVNEANRPQPIGVAGELCLAGDGLARGYVNRAELTAEKFADNPFEPGGRMYRTGDLARWTADGNVEYLGRIDHQVKIRGYRIELGEIENTLLKHGSVNEAVVTARTDASGMSYLSAYYVAVEELGASQLREHLSRSLPAYMIPAYFVQLEAMPLSANGKADRKALPEPRGLAASAAEYAAPTGETERELAVLWQELLGVEKVGVNDDFFDLGGNSLTAARLISRVHKSFGADLPLRDVFQSPTVAQLAAKITNAGQGGYTAIEPAEPREHYPLSPAQSRLFILHRMEEGGVGYHLPAALDISGPVDRERLEEAFQKLIGRHESLRTSFAMTGAEPIQTIHEHVPFKLDYTRLEESGDEPGAIEARFRAFVRPFELSEAPLLRAELIRRADNRHYLLFDMHHIVGDGISMAVLQDELIALYEGASLPDLKLQYRDYAMWRLEHANGEALRKQEAYWLDRLSGELPVLGIAGDYPRPPVKSAEGDRVSFRLSPEQAEQARRIASQAGATPYMTLLAAFKALLARYAGQDDVIVGTPVAGRPHSELEPIIGMFVNTLAIRSYPAEGKSFHTFLTEVKDASIEAFENADYPFEALANALGGSRDVSRNPVFDAMFVMQNMRRAERTIEGVTFGPLDLPTGAAKFDLLLEIVEDDGGGYECRLEYGAKLFKRETMALFAERYARLLEAAAEDPSKPIGELELLTEAERELLLSGFNDTHAAYRNDVLLHELIEEQAARTPDKFAFAFGDRKLTYRELNGQANRLARTLRAKGVGPESVVAVAMERSEEMMTALLAVLKAGGAYMPLSPDVPAERAAYMLGDSGARLALTQSGFAAEFAAKLAGTGAELLDVTEALLAGSTASLDSETSFERLGTSRSPAYIIYTSGSTGLPKGVMVEHYSVVNRLNWMQKAYPLTERDVILQKTPYTFDVSVWELFWWGTVGASVLFLEPGGEKEPEAIVRAIEAGGATTIHFVPSMLSAFLDAVEGRPEQIRRLSGLRQVFASGEALTAKQANRFRALLHEANGTRLINLYGPTEATVDVTHFDCTAHERLETVPIGRPIDNTRLYIVNEANRPQPIGVAGELCLAGDGLARGYVNRAELTAEKFADNPFEPGGRMYRTGDLARWTADGNVEYLGRIDHQVKIRGYRIELGEIENTLLKHGSVNEAVVTARTDASGMSYLSAYYVAVEELGASQLREHLSRSLPAYMIPAYFVQLEAMPLSANGKADRKALPEPRGLAASAAEYAAPTGETERELTVLWQELLGMEKIGVNDNFFEIGGNSLLLVRAHNELEKRYPGLVKLTDLFVYSTVSKLAEHVNARLSNVGQENLAEPIALPASFFARPNEPNQGRSFDFRLEADAVRALEEVCRSERIGMYPLFVASFLFVLARHAGKTDIAVPAGLPGGHLVNVKVGSSELADFPQLLSSVRRQVEAADTAAGPRKYRAEQLRSSVIPKDERHVLPLIRGKDDPGFRSGDLHPFDFALSVHIVPGQIGFRFEYNGRRLRTEKLKSLMGDFLKFVTYLSAQSRSRVEQTAATLEKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPG0</accession>
    <name>A0A398CPG0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_13440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01797">
        <property type="protein sequence ID" value="RIE01797"/>
        <property type="gene ID" value="D3H35_13440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="11"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="416" mass="43250" checksum="CA597760CAC3B38F" modified="2018-12-05" version="1">MSADKKRSTWALLALAISAFAIGTTEFISVGLLPLIADDLHISITTAGLTVSLYALGVTVGAPILTSLTSRVSRKTLLLWIMIVFIAGNSLAAAANGIALLLAARILSAFAHGIFMSIGSTLAADLVPENRRASAIAIMFSGLTVATVTGVPAGTWLGQQLGWRMAFVAIVAIGILAIIANGILVPSSLLKGTVTPIREQLKVITNGRLLLAFAITALGYGGTFVVFTYLSPLLHDVTGFKEKAIVVILLAYGIAIAIGNVLGGKAANRKPLTALFYMFASQAVVLLLLTFAAPFKIAGLLTIVLMGLLAFMNVPGLQVYVVTLAERYAPKAVDVASAMNIAAFNLGIAIGAYLGGVIADTIGLIHTPWIGSLMVAGAVALTGWSRVLEAKEVNIRRGTANRASQQSVEADTVLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPT4</accession>
    <name>A0A398CPT4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04442">
        <property type="protein sequence ID" value="RIE04442"/>
        <property type="gene ID" value="D3H35_07610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="68" mass="7535" checksum="D0F8BA7C8AFB95B1" modified="2018-12-05" version="1">MTKEEKGSVRGELVSNEWCVEKEAVQRRATCSYAESRNAPIRAIPPTGTPIFGERVASSSTQPERLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPU3</accession>
    <name>A0A398CPU3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_05530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04555">
        <property type="protein sequence ID" value="RIE04555"/>
        <property type="gene ID" value="D3H35_05530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="76"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="292" mass="32529" checksum="29F54357354E0297" modified="2018-12-05" version="1">MIRLTPGEKTFVAANYTMLTLLTLLIVTPIWYVVVVSFTPYDIFSDRNGMILFPESISMEYYSFLLKKGSLIYQAYGNTLRNTAGGVLLALVLTATAAYALAEKKLPGRRFLILIFVFTMLFRGGLIPTYLTVKQLGLLNTDYVLILVMAFSAFNMIIMKTFFEGIPESLRESAAIDGASEYRVLWQIVLPLSLPVIASIGLLYLVVYWNDFFNALLYITDWNKAPVQLVLRTIVANSSLPPELLETAGTTPPPTVGIQMAAIVIVALPMMIVYPFIQKYFEQGMLIGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPX1</accession>
    <name>A0A398CPX1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YlmC/YmxH family sporulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04482">
        <property type="protein sequence ID" value="RIE04482"/>
        <property type="gene ID" value="D3H35_06560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014238">
        <property type="entry name" value="Spore_YlmC/YmxH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40061">
        <property type="entry name" value="PTHR40061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02888">
        <property type="entry name" value="spore_YlmC_YmxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="93" mass="10223" checksum="E7580E2CE0342EA5" modified="2018-12-05" version="1">MKISDFQTKDVINIVDGKKLGQISDLELDLRQGRIDSIVVPTSARFFGMFGGGTDVVIPWRNIVKIGADVVLVRLDDARAYRNEEGEATSAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ02</accession>
    <name>A0A398CQ02_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02828">
        <property type="protein sequence ID" value="RIE02828"/>
        <property type="gene ID" value="D3H35_19545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="111" mass="12071" checksum="E52835981A2A03FE" modified="2018-12-05" version="1">MSATTTLPGRTTLPLPTRRFPAITEFAPIVAPSPITNAPSVNATPWARTGMPTSSYRWSVSDRLTLEPMRALFPSSTLFTADKLNPMPQTQPSPIIIFGPSLSFRGTILNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQH4</accession>
    <name>A0A398CQH4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01671">
        <property type="protein sequence ID" value="RIE01671"/>
        <property type="gene ID" value="D3H35_22685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="164" mass="18897" checksum="D91CAF50C8E4DCF1" modified="2018-12-05" version="1">MRTSAAPVVVMMCGVAGSGKTTFAQKLEKEGFVRLSIDEDIWATHGRFGVDYPEQNYESYKEESEIKLRGVLVNLVQTKHHVVIDFSFWQRQRRSDYKQLIERHGGVWELIHLKVQPEELRQRLLIRSERFDANAAFPITEDTLTRFLSGFETPSGEGELVIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR24</accession>
    <name>A0A398CR24_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02277">
        <property type="protein sequence ID" value="RIE02277"/>
        <property type="gene ID" value="D3H35_16255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="64" mass="6902" checksum="2D1F0F3D6F5D14B5" modified="2018-12-05" version="1">MLLELLPDLRRMRRPRALEPDFIGALGASVLFSAVRKVGLYNCQRSSGVGGRANGGINQLGLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR41</accession>
    <name>A0A398CR41_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BMP family ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_11160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03258">
        <property type="protein sequence ID" value="RIE03258"/>
        <property type="gene ID" value="D3H35_11160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017354108" evidence="3">
        <location>
            <begin position="27"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Bmp" evidence="4">
        <location>
            <begin position="62"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="388" mass="41663" checksum="6AC755D608B94C0F" modified="2018-12-05" version="1">MRNRTKSLSIGLVVLLLFAFTLAGCGSSNKKNEASPSGSSSPAVSPSATQAASPSDEKKLPRVAFVYIGPPGDGGWTFQHDEGRKYLEEKTGIKATTVENVPESADAERVITELAQNHDIIFTTSFGYMDYTVNVAKKFPKVVFVHCGGYKTDVNMATYFGKNWEASYLSGIAAGKATKTNHLGYVAAFPIPELIYNINAYTLGAQSVNPDVKVSVVWSNTWYDPTTERQAAISLLDKGADVLMAYQDSPATLQAAAERGAKAGGNDSDMTRFAPDAYLTNPVWVWGPFYVKTVEAVMAGTWKSESFLGSFVDGTVDLAPLGSSVDPEAKAKIEELLAKYKKEDPSIFTGPLVDQSGAEKVASGKVLTDAEVLSMDWFVKGVDGSIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRX9</accession>
    <name>A0A398CRX9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_00760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CpsD/CapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05355">
        <property type="protein sequence ID" value="RIE05355"/>
        <property type="gene ID" value="D3H35_00760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="AAA_31" evidence="9">
        <location>
            <begin position="40"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE05355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="214" mass="23149" checksum="53123FD0248F28CB" modified="2018-12-05" version="1">MSRWMRKRGRIAGTNPKSDVAESYRRLRTGIELSNRDGKVKTIAIASAEPGEGKSTTSANIAIAYAQANRRVLLLDSDLREPDQHRIFELQNDKGLSTALAGRAGIGEVLQQTEFANLHVICSGPIPLNPSELLESEAMNVLLEEAKTSFDIVILDTPAMTVAADALIVADKCDGAVLVIRRGKTKLEAAARAKETLESGRARIVGAVFNRIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRY3</accession>
    <name>A0A398CRY3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_01165</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000011">
        <property type="protein sequence ID" value="RIE05313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05313">
        <property type="protein sequence ID" value="RIE05313"/>
        <property type="gene ID" value="D3H35_01165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="58"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE05313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="246" mass="27288" checksum="746D8809C3BAF730" modified="2018-12-05" version="1">MIYETPLLTLDGNLVGMLQVGAYTEREESLFSFLRSILIFAGLFSIAAAFSLGMLVSRKALRPIGRVTEAAEQIQSGSELGLRIPRETPNDEIGRLTDTLNGMLPRLEVAYNHLEESNTAQRRFVSDASHELRTPLTTIRGNVDLLEKIWTLPPEGSEGHAAHKLPEAERKTMSLEAISDIADEARRMSRLVNDLLSLARADAGYAMEMNTLSLRPLAEEAARRASFLPRHAEWIVARSKRSTAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRZ4</accession>
    <name>A0A398CRZ4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen synthase</fullName>
            <ecNumber evidence="7">2.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Starch [bacterial glycogen] synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glgA</name>
        <name evidence="10" type="ORF">D3H35_08505</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Synthesizes alpha-1,4-glucan chains using ADP-glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18189"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.21" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03989">
        <property type="protein sequence ID" value="RIE03989"/>
        <property type="gene ID" value="D3H35_08505"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00484">
        <property type="entry name" value="Glycogen_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011835">
        <property type="entry name" value="GS/SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02095">
        <property type="entry name" value="glgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_5" evidence="9">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="8">
        <location>
            <begin position="291"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="476" mass="54001" checksum="DB1B4EB3DEBEEE88" modified="2018-12-05" version="1">MEKSVLFVTSQLYPYTTGTMGVFNFSLPKHLIGLGWDARVIVPRIPNPYKEYPADIRVAASLDIPMGERSYECDIEFGSYDGVPVYFVNAPAYFGRKELYGHEDEAERFGYFCKAVLEALPQAGFRPSILHIQDWHTGLIPFLLRTKYKEEPFYEGVKTLLTVHNLGYQGVFDKENASLLDVPWEKWVENGADYYDQISFMKAGLLHADSLTTVSPTYAKEIATEQYGSTLEATVQRRSNDLYGILCGLDTEINNPAADVRIHARYDENSPELKLANKRALQQALGFPQRDDVPIVSLFSRLKTEKGLDLVMSAFEDLMRLDLQFVIVSNGDAVYEEFFRRAAIRHPDRFAFVLYDNDFAYQAYAGADLFLMPSGYEPCGIGQLIALRYGAVPIVRQVGGLNDSIRPFDEATGAGNGFVFKPYHPRVMLYAIRKALEAYKRPDTWRTLVTNGMSENHGWPVYVKQYADVYERMLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS29</accession>
    <name>A0A398CS29_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04029">
        <property type="protein sequence ID" value="RIE04029"/>
        <property type="gene ID" value="D3H35_08735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="448" mass="50384" checksum="C7F5C916CC6F32D0" modified="2018-12-05" version="1">MNTAHEHGQFRLAATRALAAVYELWMVLPLWLLAHHIEYVHVAAAGKWLALAALASALSGAASVWIRTVWKQALVSLLSAGLVGAIVSAMSDLSFFGAIPLFLAMLLGFTVGYRYGWAGWYWTGVGVFFAISSLFNIVPGWNDYSSLLMFGGVVCLAAALFASNVIHLRKVTYSSDNPRRVPVEIKRHNRFFVAGLLIGALLLAAGLGSLIVYAIKHTVVALIRWIYDLLSRRPKGMPMPEPEETPAPTPVIGEGEPLPDWSWLINLLEKITLVVGVTILALLLLWGAYYIFRNRNGFWKKWFKWLSALLRRSEKAASASGFTDEESSLFSWEEAKGRLRRSLLGRMLGRKEPSYENLPDNRERARFLYRKWLRDRIGEGYGAKRHLTPEETLADAQVWRASKDKRKKAEPDSNAERQLVDVYYRARYSQEEPSDEELALARSKRSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS85</accession>
    <name>A0A398CS85_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_02765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05070">
        <property type="protein sequence ID" value="RIE05070"/>
        <property type="gene ID" value="D3H35_02765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007742">
        <property type="entry name" value="NosD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05048">
        <property type="entry name" value="NosD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="1429"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="1488"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="1556"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1250"/>
            <end position="1277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1614" mass="169691" checksum="094B6ED260EB7D80" modified="2018-12-05" version="1">MFKNNIFTKPIRTQLEGGKSIIDASQNVVFDHNVYSIAGTQRVTYNGGGEGPVLTLAGLQSGTAWANQGRALETNGKFGNVTFVNSASDARIIFATNPAIGAADTSIVPGIEAPATDVNGKVRTQNEVGAYAFDQTFAFVGTNSGAADGSPLHPYPSISAAVNAGAKSIQVLAGSYNADESIDMAASTGNGDVTVKPYEGQVIINGALNVKGSADKAITIKNLTIAGSTALSGKKVTIDGNRINGVVALYQADGAAVTNNIFAPKAADAILVNDSVNSSITNNVITERQTAIHLADASAANKVFNNTLYGNGKDVDLSADSTGNIFKNNIFSTKRASNASNEFDYNLYNADTIGQADLNAIAEAHAVKAPAEFINARAKDYRIYKLSPAVGAGITDANTPAKDINGIMRKIPSDIGAYSAAAVDVSYYVDASTGKDTNSGTAESPFKTIGAGLNALRNGETVIVKAGTYTENIVLANRTAQETGEYTIKAVGAAILNGSITLDNATGVTIDGFTVNAGAGNTAVSLNASPKAALNNLTIANAKYGISATDSPNLSMNKVNIHHVEKGIVLDGIGEATPATVTRSTVDHASAVAIEAKNQIVLTLNTSLITYSAAGVAGTGEPSFSIFNNTFYNNSGYSIDIAQAGGNAANPAIVNNIFSRSSRGQGAFTRIDKMGGFISDYNLYDASAEEKITRVNGVDRTYAETAANGNEQKGRIGSPSFKDAANGNYKLSKGSTASRTGAKSVSGIPAPSVDFEGTPYSALGQDIGAYYSPYSIKTIHLAGDNAGELNGDGSAEHPFRTFAQAVNAADSGDTIIVHKGIYSGRYDINNKHGVADAPIVIKASTNPNDPLDLANFSLPGPVFTSKTNYQDRDEAAKGDLMTKITNSSYLTIEGLYITGFKGAGIWTLDSDNIVLKNLNIWDIDTPEEVTSGVQGLLINGTTNSLFKDINIWDIGQTRKSQADHGAYIGHGSNLVFDGIKVSNSPGGGLQFYAGDNYDIHATDIVVKNSVFSESKYGLILVGIERVTVTNNTFYNSWENDLYLDWNVRNNLFQNNIFYNDRTEEYDSVYGKVKPVIIGYQYNVVRTNSDQTTTPMVVGNTFRNNMYDYKTFPANAQFVTNVMSIKDFMTAENAAATNNRYTNMFKGNVSFKGSIAGAADEYERAQRIFDDILDVTSASASINKGVSENAPNVDILGRARVGKPDLGAYEYIPSHTDNGGNTGGGGTTPVVPSGEAEGTIANPALDSKTGIASAKMTAEELENALKSASIEADGTKRIEIKLPDTQNAGAYSVEIPNPAAASTDSVVLVISTSAGTVSIPNSVLNAAGADNIVLNIGAAHSSAIGTRPAVTVTLTEGGKPIALTAGNDKVEVMLPYTPTAEERKHAESITVWRVDSEGKAIAVPSARYDKAAGVIVFEAEAQGTYAVADGFKTFNDVEKIAWAKHPVEVLASKGIIHGLSADRFAPTANISRGDFVALLVRTLGLQAAANVNFDDVKTGDYYYEEIAIARSLGIASGVDQGLFNPKKSISRQDMIVLTNRALQAAGLLKPGATGNELDKFADKSNVSDYARETVSALVKEGIIAGSGGKLNPLGMTTRSEAAVLLYNIYNKRYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT44</accession>
    <name>A0A398CT44_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Winged helix DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01035</name>
        <name evidence="1" type="ORF">D3H35_03030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000008">
        <property type="protein sequence ID" value="RIE05330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05114">
        <property type="protein sequence ID" value="RIE05114"/>
        <property type="gene ID" value="D3H35_03030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05330">
        <property type="protein sequence ID" value="RIE05330"/>
        <property type="gene ID" value="D3H35_01035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="384" mass="42473" checksum="A91AE6CA281BDB56" modified="2018-12-05" version="1">MSAYHKTPRKSDATEKQRVPVLGTRALNRALLARQMLLRREKLPALDVIERLVGMQAQAPNAPYFGLWTRIEGFAQEELSRLIQDRKAVRIALMRSTLHLASAEDCLQLRPWVRAVQEKGLASTYGKRLAGIDADALAAAGREAVEAEPLTFSELGKSLQKRWPGRDPAALSAAIRTYVPLVQVPPRGLWGEGGQAAHTSAEAWLGQPLCAEPSAESIVLRYLSAYGPASVKDVQVWSGLTRLGETIEKLRPQLAVFRDEAGRELFDVPDAPRPDADTDCPVRFLGEFDNILLSYEDRKRILPEEYKKRVFTENGIIRSAILVDGFVSGLWRIARSGGTATLIIEPFKTLSTRERDALAEEGTRLLEFATVDSGESRVIAFVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTB9</accession>
    <name>A0A398CTB9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">U32 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03077">
        <property type="protein sequence ID" value="RIE03077"/>
        <property type="gene ID" value="D3H35_21075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001539">
        <property type="entry name" value="Peptidase_U32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01136">
        <property type="entry name" value="Peptidase_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="315" mass="35200" checksum="5D2F23F298785483" modified="2018-12-05" version="1">MGKVTTDTRLELLISAGSAAQADKYLEAGATAILIGESRFGMRLPGEIREDELKEVIALIHERGGKAYVNAGKLFRNEELSALPAYLRSAAAAGADAITFGDPAVLLNAREFAPSLKLHWNAEMTGTNSAAAGYWGRRGAIRAVLARELNEEEIADFKRNVELEVQIQVHGMTNIYHSHRNLLESYLQHIGREATLVERGADKGLFLVEMERPDERFPVYEDANGTHVMSPDDICLLEALPELYAAGVDSLYVEALLKTEEYNETVLRAYREAIDRLVANPDSYKFDERGLNRIRALQHPERELGFGFLYKEQVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU16</accession>
    <name>A0A398CU16_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spore gernimation protein KB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_19445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02811">
        <property type="protein sequence ID" value="RIE02811"/>
        <property type="gene ID" value="D3H35_19445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004761">
        <property type="entry name" value="Spore_GerAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34975">
        <property type="entry name" value="PTHR34975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03845">
        <property type="entry name" value="Spore_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00912">
        <property type="entry name" value="2A0309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="410" mass="45489" checksum="C38338BD27BAA84B" modified="2018-12-05" version="1">MGRSICESGCERLVPGGHSENRHAREIAAGKNERRRDFGMKYPLEHMGPLHLFSWVVLFELGSAVVIPIGMEAKQATWIVILLGCLFGLVYMGAVYGTLYRMFPDIPLTGYARQIAGTVPGWLIGFAYLLYFVYIASRNTRDFGDLLAAASYDSTPLSALNLFMVVAVGYVIHFGLEVFGRTAFVFFLFTGAIFSFILLLVVFSDMSEYRRMLPILGDGWKPVWKALFPTNITFPFGELVVFTMLLPHMNKKFKAVRIGMGAMIASALLLCIATFVDISVLGVEIASRATFPLFTSLSRLRLAEFVQRMDSVVLLLLVITSFFKIGAFMFAAILAARDLFRTDNYKTLIMPVGIVVFCSSLVMAGSLTEHLEEGLKVVPLYVHLPFQFGLPAVLLLIAVLRGHRVRSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUN2</accession>
    <name>A0A398CUN2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Redoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_07115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04358">
        <property type="protein sequence ID" value="RIE04358"/>
        <property type="gene ID" value="D3H35_07115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="5"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="184" mass="20546" checksum="C2B0A3AD41739815" modified="2018-12-05" version="1">MVRLLQPGMIAPTFSTTDINGNSLALESYRSRKVLLSFFRFSACALCNLRVHRLIGRYPQWQRQGMDVIAVFESPLSNMKTYVGAQNAPFLLVADPMAALYELYGIETSEEKVQATLADAHTKDYIAEAVAAGFELTPEKDSNFHRIPADFLIDENGIVQGVHYNQLITDHLDFVAIDRFASNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV36</accession>
    <name>A0A398CV36_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T5orf172 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03747">
        <property type="protein sequence ID" value="RIE03747"/>
        <property type="gene ID" value="D3H35_09320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T5orf172" evidence="1">
        <location>
            <begin position="49"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="101" mass="11837" checksum="8DC2E30A2FF4A989" modified="2018-12-05" version="1">MILSGQIEDLKINTLNTFVILKFGFTKIISPLRNKQLFLTSLVWKNLQATAGSYSRYFPKTFSIYSTCRNRCYLAEKLIHERLSQYRINPSREFLRLPIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVM5</accession>
    <name>A0A398CVM5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_00865</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05369">
        <property type="protein sequence ID" value="RIE05369"/>
        <property type="gene ID" value="D3H35_00865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="23"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="357"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="393"/>
            <end position="400"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE05369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="592" mass="66193" checksum="D0F43B07BEE040DB" modified="2018-12-05" version="1">MTDLWFYLNRLRSFAGNRLYTQLAAMIALGLFDGVGVYLLAPMLGLLGLFGDASANVPLAGDWFEALRELPASYALPVLLTVYVLVMTIQALLQREQSVRSVRLQQGFIRHLRLRLYEALMRSSWIFFVRRRKSDFQHQLTSELARVSQATYLLLQLVSSLAFTVIQIGFAFWLSAKLTAIVLISGTGIALAMRRKIRSAKEIGNQTSELSQSYLAGLTDHLGGIKDIKSNRLEASYLAWFRDLTGRMEANFIALARLQAATQSFYKIAAAALIALFVYLAFEVFHVGAGQLMLIVIIFSRLWPRFTAIQAGAEQIVSAIPAFRSLRQLERECGEAREWTDMDGIGQVRDIRVTQGIECRNVYFRYGEDRTSEYALRDVCVHIPSGKMTAIIGKSGAGKSTLVDMLTGLLEPESGTVRIDGVPVGQDARIALRHAVGYVAQDPFLFHASIRDNLLAVRPDAGEEELWKALRFSASDDFVKRLPEGLDTLVGDRGVRLSGGERQRLVLARAILRRPSILVLDEATSALDSENETLIQEAIDRLKGTMTIIVIAHRLSTIRGADQVIVLERGEVRVREEHRNSFKEECRQSLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVP0</accession>
    <name>A0A398CVP0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03084">
        <property type="protein sequence ID" value="RIE03084"/>
        <property type="gene ID" value="D3H35_21110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="129" mass="14505" checksum="F65633D9E8193A95" modified="2018-12-05" version="1">MARTDSHQWDAVPFFRRIVGAHAQQRDEVPLFRQTAPAALRNLQIKELPQGYQALRQLLHSERTYLLSYRKSGERLAKLGRYRFQSIGQLHQAVADAKLLIAERSDCSEVADASSATALTLLIASESVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVP4</accession>
    <name>A0A398CVP4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_03690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04608">
        <property type="protein sequence ID" value="RIE04608"/>
        <property type="gene ID" value="D3H35_03690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004688">
        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="PTHR31611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00802">
        <property type="entry name" value="nico"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="339" mass="38022" checksum="492676A71458AA18" modified="2018-12-05" version="1">MLKALLASRKSWQSYFIVVILLHIVGFIGLYSVTRENVAFWSMGLLAYTLGLRHAFDADHIAAIDNTVRKLVQQKRSPHGVGFYFSLGHSSVVFLMVLAIALSIHWLQDRMPQMQEIGGVIGMTVSGSFLVLIGILNLIILISLVKLFRKMRHGEYDNEELERLLESRGLFARLLRPLFRFVNRSWHVYPLGFLFGLGFDTATEIGLLAISAVAAQGSVSFFGILSLPILFAAGMSLLDTADGMFMTGAYRWAFNTPLRKLYYNTTVTTISIIAALVIGVVELVQIASEKFELTSPVFVWFGQLDFEYLGYVLAGLFLLSWIVSLTVWKVMKVEQRYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVT8</accession>
    <name>A0A398CVT8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000005">
        <property type="protein sequence ID" value="RIE05429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05429">
        <property type="protein sequence ID" value="RIE05429"/>
        <property type="gene ID" value="D3H35_00415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="346" mass="40252" checksum="255B587F2BFB370E" modified="2018-12-05" version="1">MENKATPREIYEKHLKQLQQTLLWEDASVIGIKNEDPADLALQAEVTASSYLSRLAVESADEAFELATDVAFLMPVDPNIEKIQILLDAADDTSVEVEVWDTGRQENYIPYQLQVRDVQTIKKGNKQWIEFNLPWSPESTQNAFVVIKENPSVSVYLSHQPMSGVLSFVREKALNVARGMESLNHDQLVVKWNMKRVVRKPFCFRLATETKAYEPAKIMDGYQRPYGGAHMWLSEPSKDDAWVALKWDKEVEFNEIHITFNDDVNEDLINLHHHRTEFDVIPELVRDYRLEVFEKGNWRILFEVKGNRQRKRKHTLENDVRTEQLRLVVEQTNGTAYAEIVEIRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVU8</accession>
    <name>A0A398CVU8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_00465</name>
        <name evidence="5" type="ORF">D3H35_00485</name>
        <name evidence="3" type="ORF">D3H35_13120</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000005">
        <property type="protein sequence ID" value="RIE05439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000005">
        <property type="protein sequence ID" value="RIE05443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01740">
        <property type="protein sequence ID" value="RIE01740"/>
        <property type="gene ID" value="D3H35_13120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05439">
        <property type="protein sequence ID" value="RIE05439"/>
        <property type="gene ID" value="D3H35_00465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05443">
        <property type="protein sequence ID" value="RIE05443"/>
        <property type="gene ID" value="D3H35_00485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="190"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="296" mass="34891" checksum="7B3235DD4A8A0FE1" modified="2018-12-05" version="1">MRLRIIIHSEGDSMNDALGDLHNMVPHFTQVIHRVVNGSWVNHRKVWDTHSFILVYDGEAVIGCNEEQRVGKGDLIYFKPGDVRWGYTFEDNPMKCYGMDFKYSCLLFDNDDWIKKDIPLPIQSFLHLNDSHLFSRVLHLFQNLTKEWISPTTFNKVSRERAYFMEILNLLFLWNSSKQSLNYDKIRKVEKVSQYILDNYSRKVKLQDLADYIQLSQSYLQVIFKDITGSSPIEYLINVRINKSKELMKEGYQNIGEISELVGFNDAFYFSRCFKRIEGITPTEYRSTISSQRQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVV0</accession>
    <name>A0A398CVV0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04007">
        <property type="protein sequence ID" value="RIE04007"/>
        <property type="gene ID" value="D3H35_08615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="176" mass="19672" checksum="1C622F6D8C508569" modified="2018-12-05" version="1">MMSDNRIVIREETPSDREAVKAVLFDAYGQYENTLSRERWEQYKENIEASAAGGPTKARLVAELDGEIVGSVFVFESSDTAYGYSGIDTPIIRLLAVSQKARGFGVATELIRASAKLSRGWGAQTLHLHTSDLMESAVRLYERLGFERAYDYDIQNGEILVKSYRLQLKEAALLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVY5</accession>
    <name>A0A398CVY5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2,3-diketo-5-methylthiopentyl-1-phosphate enolase</fullName>
            <ecNumber evidence="4">5.3.2.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_04220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.5" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04698">
        <property type="protein sequence ID" value="RIE04698"/>
        <property type="gene ID" value="D3H35_04220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043715">
        <property type="term" value="F:2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016984">
        <property type="term" value="F:ribulose-bisphosphate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08209">
        <property type="entry name" value="RLP_DK-MTP-1-P-enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017717">
        <property type="entry name" value="Diketo-Methiopentyl-P_enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033966">
        <property type="entry name" value="RuBisCO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000685">
        <property type="entry name" value="RuBisCO_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036376">
        <property type="entry name" value="RuBisCO_lsu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036422">
        <property type="entry name" value="RuBisCO_lsu_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42704">
        <property type="entry name" value="PTHR42704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00016">
        <property type="entry name" value="RuBisCO_large"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00157">
        <property type="entry name" value="2_3-diketo-5-methylthiopentyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00014">
        <property type="entry name" value="RuBisCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51649">
        <property type="entry name" value="SSF51649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54966">
        <property type="entry name" value="SSF54966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03332">
        <property type="entry name" value="salvage_mtnW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RuBisCO_large" evidence="3">
        <location>
            <begin position="124"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="409" mass="43621" checksum="8CC9F65958D9B913" modified="2018-12-05" version="1">MNSSYSKATYRLYDDKADFNKKATGIAVGLTVGSWTELPEAAKQHMKKHLGEVVSVDVHEPDGAQPGERYADITIAYPDANFSRDIPALLVTVFGKLSMDGRIKLLDLQPSAEFLSAFPGPKFGIEGVRGLLGVPHRPLVMSIFKSVIGHDLAGLREQFLQQALGGVDLIKDDEILFENPLTPLEKRVEACMDAAREAERATGQKLIYFANLTGSTFKLRENALRAIDAGANGLLFNVLAYGFDALAELAADSAINVPIAAHPAMAGAYYPSAHHGIAAPLLLGKLMRIAGADLSLFPSPYGSVVMPKEENLAVQQALVTDELPQKKAFPVPSAGIHPGLTPLILSDFGTEVVVNAGGGVHGHPNGAAAGGQAFRQAVDAVLAGQSLEEYAKNNEQLRLAIERWGVHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVY7</accession>
    <name>A0A398CVY7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_08840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04047">
        <property type="protein sequence ID" value="RIE04047"/>
        <property type="gene ID" value="D3H35_08840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="112"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="344" mass="38158" checksum="166BB5C1E688DD93" modified="2018-12-05" version="1">MAQSTVNGRESKYVYWSRIGRKACQYALVLFIALTINFSLPRLAPGDPLSYLFGTEVNSLSEEQRDQVNSELGLDRSILSQYADFLAGAFTLELGSSTKFGKPVTEVLADSLPWSLLIIGPALLLSPFAGILFGAYAAWHRAKRRDIVLLVLMLTMEAMPVFWAGMLLIAIFSVQLGWLPSYGAVPLIHPGNTLDYGLEVLRRMVLPVITITFSSIGTYFLMTRFSMLDTLGQDYMTMAEAKGVRPRRLLYGHALRNALLPVYTHFTMSLGILLGGAVIVETVFSYPGIGRLLYESVIARDYPMMQGVFLMITVGVIIANLLADLTYPLVDPRVRTRRALEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWL9</accession>
    <name>A0A398CWL9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Asparagine synthetase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_06315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04227">
        <property type="protein sequence ID" value="RIE04227"/>
        <property type="gene ID" value="D3H35_06315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="6">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="643" mass="72897" checksum="2BEBF207D5499B61" modified="2018-12-05" version="1">MRDGMGSIVGIFSWGSRPIQQQTRENLMSGLASYPADDRHTWQSGSVFLGSCQRWITSESRLERQPYVDESNGLAIVADAILDNREELRRRLAIDAGKLAGIGDGELILEAYRKWGTSVYEYLLGDYAFVIWDEPKRMLFGARDPLGHRTLYYRNDRSLGQFAFCSSMTPLQRLPDANPGLNMDWLAEFLAFPNLSEFSDDNSSPFAGIGKLGPGRYFTLRNGIFTANAFGALLPNETLRLRSDSEYEEAFCDVFGAAVNARLRTFREVGASLSGGLDSGAVAGFAANSLRSEGKVLHTYSYVPPGDFQDWTHAGAMPDERPLIRQTIAHVGNIREEYLSVPGGDPYSDIDDTLALREEPYKFFENAFWVKSIYAQARQDGVGILLTGAQGNHTISWGSAPYYFSYLLKKFRWLKLYREFQQYSRQLRVKRSRLFRALIDQRQHEGERSFPAMIHPEFAQRSEVYGRREHADGLDSLSSLDERAARENHFASSAVRHAIGSSVSALSHRYGLWERDPTSDARVIRFCLALPMEQYVQNGFDRALVRRSLRHILPDSVRLNQRVRGVQGVDWVHRMRASWPVFLAEADAIRRDSAASELFNVEQIRLSLDRIGTEPRPELACDADARFLMQCVIAFRFVKKAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWR2</accession>
    <name>A0A398CWR2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04277">
        <property type="protein sequence ID" value="RIE04277"/>
        <property type="gene ID" value="D3H35_06595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024442">
        <property type="entry name" value="Transposase_Zn_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12760">
        <property type="entry name" value="Zn_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_Tnp_IS1595" evidence="1">
        <location>
            <begin position="17"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="310" mass="35584" checksum="BC401E979EE2D1EF" modified="2018-12-05" version="1">MFEDYSTFESFCQHFDSERACADALYDARWPNGFRCPECRHTRSYVIRTRRLPLFECCSCRHQTSITCGTIMEGSSTSLTRWFQAIYLLSQPAGISATRLSEIIQVTYKTAWLIAHKIRHAISQADNCEPLEGIVQVGHAHYGYSGYSDAKQPLLVGVSFDKHEQMQYIKMKQPKPEHVKNSTFRLIGKAGCDEFVDTHTDGRNVTVSKPFDKLHSSVKPLVRAMSDWLNETFHGIGPKHLQAYWDEFCFRLNMKWNNVASFGRLLSFSASTPVIIYKDLIREKPVLAVPWLVWGTKGKWKGSYLSLWHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWW8</accession>
    <name>A0A398CWW8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9 11">Uracil-DNA glycosylase</fullName>
            <shortName evidence="9">UDG</shortName>
            <ecNumber evidence="4 9 11">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ung</name>
        <name evidence="13" type="ORF">D3H35_06920</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9 11">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 11">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 11">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="4 9 11"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04327">
        <property type="protein sequence ID" value="RIE04327"/>
        <property type="gene ID" value="D3H35_06920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="12">
        <location>
            <begin position="50"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9 10">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE04327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="226" mass="25745" checksum="3D077E51F49E4A29" modified="2018-12-05" version="1">MTVAIANEWGTLLQEEMDKPYYKELQLKLSEEYRERTIYPERSRIFQALQWTAYDSVKVVILGQDPYHGPGQAHGLSFSVLPGVKQPPSLKNIFKELKEDLGCAIPDHGSLEQWAKQGVLLLNAVLTVRESEANSHRKLGWETFTDRIIALLNDRERPIVFILWGRHAQEKAIFIDEARHLVIRSAHPSPLSAYNGFYGSKPFSKANEFLTAIGQQGIDWQISSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXE8</accession>
    <name>A0A398CXE8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05258">
        <property type="protein sequence ID" value="RIE05258"/>
        <property type="gene ID" value="D3H35_01685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_DH" evidence="1">
        <location>
            <begin position="389"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="671" mass="72236" checksum="D811D3499E06732A" modified="2018-12-05" version="1">MREEGRRLCHRTGYRWLVRSIGFAARTKCVDSRADGTCQDGGSRVPKASVKAIDLDRTGLSAEDAAERIFRELIAGGPEYEVGLQIDGGRMTPALELAPLKAEVGARTGGPAVLLVSGGARGVTASAVTELARAERLRLILLGRTPLEEEPIVCRGIEDDAGLKRALLEQVKAEGAAVALPELGRRVQRILMNREIAANLQSLRELGSEVVYVPADVQDTSALREALRPIRAAWGPITGIVHGAGVLADKAIADKSVEQFDYVFDTKVGGLRALLAVTEEDPLALICLFSSVSARSGNAGQADYAMANEVLNKCAQAEAKRRGPGCTVKSINWGPWDGGMVSPLLKKHFEQRGVNLIPLKEGTAAFVAETSNANGPVEVVIGGGSADRQTLIEGAVEKEWSAELFLPKQPLPPWLDDHRIGGKAVVPAVIALDWFVRAASAAYPHLAVLQCQNLSVKKGIVAGENGSTEKRLILTCRDRSDGLAQATLSFELRGADGQLHYTADVEMGIKAEVAPTCRAAESTSGGADWGWSLSDIYDRNRLFHGPGFRVIRELTGLVDEGAEAIFWHDDSTAWSLREGGIDPAMIDGGLQLARLWGLRTFGEPTLPTTIGSYGAYGSLPEDRPVVCRIRSERRGRYKTVSQLTWLNEAGEIVAELRDVEMHIVANHGKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXZ8</accession>
    <name>A0A398CXZ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IDEAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04667">
        <property type="protein sequence ID" value="RIE04667"/>
        <property type="gene ID" value="D3H35_04035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014957">
        <property type="entry name" value="IDEAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027393">
        <property type="entry name" value="Virus_scaffolding_prot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08858">
        <property type="entry name" value="IDEAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00914">
        <property type="entry name" value="IDEAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IDEAL" evidence="1">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="60" mass="7047" checksum="A1AFF20B254B51DB" modified="2018-12-05" version="1">MDNMKVAYENMLGLAAEMVLDEALRKYRTEKLYEDIDDALARHDPEQFRLLTDELKTILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY24</accession>
    <name>A0A398CY24_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">S-adenosylmethionine decarboxylase proenzyme</fullName>
            <shortName evidence="10">AdoMetDC</shortName>
            <shortName evidence="10">SAMDC</shortName>
            <ecNumber evidence="10">4.1.1.50</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="10">S-adenosylmethionine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="10">S-adenosylmethionine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="10" type="primary">speH</name>
        <name evidence="11" type="ORF">D3H35_07955</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>H(+) + S-adenosyl-L-methionine = CO2 + S-adenosyl 3-(methylsulfanyl)propylamine</text>
            <dbReference type="Rhea" id="RHEA:15981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="4.1.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="10">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="10"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03894">
        <property type="protein sequence ID" value="RIE03894"/>
        <property type="gene ID" value="D3H35_07955"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006557">
        <property type="term" value="P:S-adenosylmethioninamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00464">
        <property type="entry name" value="AdoMetDC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042286">
        <property type="entry name" value="AdoMetDC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003826">
        <property type="entry name" value="AdoMetDC_fam_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042284">
        <property type="entry name" value="AdoMetDC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017716">
        <property type="entry name" value="S-AdoMet_deCOase_pro-enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33866">
        <property type="entry name" value="PTHR33866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02675">
        <property type="entry name" value="AdoMet_dc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="SSF56276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03330">
        <property type="entry name" value="SAM_DCase_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2 10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 10" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 10" id="KW-0704">Schiff base</keyword>
    <keyword evidence="4 10" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023221347" description="S-adenosylmethionine decarboxylase beta chain" evidence="10">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023221348" description="S-adenosylmethionine decarboxylase alpha chain" evidence="10">
        <location>
            <begin position="65"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="10">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="10">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for catalytic activity" evidence="10">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autolysis" evidence="10">
        <location>
            <begin position="64"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="10">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE03894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="132" mass="14476" checksum="2CB4F567185B5DB0" modified="2018-12-05" version="1">MEYSTFGRHVAVDTWGVSFDMLNSAELLQAHMVEAAEACGATVLSVQAQQFEPQGATVLVLLSESHLSIHTYPEKGFAAIDCYTCGETVDPQAAIDYLVSVLKPERTYAKKLVRGLGELQVEEPKMKQVELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYA0</accession>
    <name>A0A398CYA0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flotillin-like protein FloA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">floA</name>
        <name evidence="6" type="ORF">D3H35_06160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooligomerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane raft</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the flotillin-like FloA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04201">
        <property type="protein sequence ID" value="RIE04201"/>
        <property type="gene ID" value="D3H35_06160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01562">
        <property type="entry name" value="FloA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022853">
        <property type="entry name" value="FloA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12127">
        <property type="entry name" value="YdfA_immunity"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="326" mass="34785" checksum="33FA838C1953FB73" modified="2018-12-05" version="1">MDSNVQLLVIIALAVIAVSVFLSFFPFMLWISAIASGVRVSIITLVAMRLRRVIPSRIVNPLIKATKAGLGLTINQLESHFLAGGNVDRVVNALIAAQRANIPLEFERAAAIDLAGRDVLQAVQMSVNPRVIETPVVSAVAKDGIEVKVKARVTVRANIDRLVGGAGEETIIARVGEGIVSTNGGANSHKDVLENPDLISRTVLGKGLDAGTAFEILSIDIADVDVGKNIGAHLQTEQAEADKRIAQAKAEERRAMAVAQEQEMKARVVEMQAKVVEAESEVPLAMAEALKSGKLGVMDYMNLKNIEADTEMRGSIGKNGDGDIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYB3</accession>
    <name>A0A398CYB3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04797">
        <property type="protein sequence ID" value="RIE04797"/>
        <property type="gene ID" value="D3H35_04830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="108" mass="12330" checksum="2F83A17CBF36D6A0" modified="2018-12-05" version="1">MIRYADEKWDELRFVNFRPEVDKRDGQWIDVALEVETDSNTPLPEDIIEFSIVIVCTHKGHPIQAVTLEQGCDSEYQLTAAEKEQIFAYIATEEMQRAIVAAAGEDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYP0</accession>
    <name>A0A398CYP0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_03145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04947">
        <property type="protein sequence ID" value="RIE04947"/>
        <property type="gene ID" value="D3H35_03145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="84"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="138" mass="15197" checksum="70F5081575412897" modified="2018-12-05" version="1">MRRTVIATIGVPGELCISGAGLARGYLNQPELTAEKFVANPFAPGERMYRTGDLARWLPDGNIEYLGRIDEQVKVRGHRIELGEVESALRSHESVKEATVIARKDEEGSAYLCAYFVANGNLGAAELRKHLLEMLPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0R8</accession>
    <name>A0A398D0R8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">hflX</name>
        <name evidence="10" type="ORF">D3H35_04610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04764">
        <property type="protein sequence ID" value="RIE04764"/>
        <property type="gene ID" value="D3H35_04610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="9">
        <location>
            <begin position="208"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="214"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="239"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="261"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="327"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="428" mass="46907" checksum="41AA2BD996D89341" modified="2018-12-05" version="1">MIPNTYETGAGAAEKAILVSLVTDQVKRSGADPKHSLEELVSLTETAGVEVIATLMQQREVPDSRWFVGKGKAQEIKEMAAETGATTAVFDQELSGAQVRNLEEELDLKIIDRTQLILDIFAGRAKTREGILQVELAQLSYLLPRLSGHGKNLSRLGGGIGTRGPGETKLETDRRHIRDRITELKRQLEAVTQHRTLHRERRRKAGVVQVALVGYTNAGKSTLLRQLTAADVLVEDKLFATLDPTSRTLTLPSGKEVLLTDTVGFIQNLPHDLVAAFRATLEEANEADLLLHISDASSPMRERQQKVVEEVLGELGAAGKTTVHVWNKIDLCSSASLSLLPGGNDSLRISAFKPNDLDKLKEAVEDKILGGVCMLRIPASRGDLASLAYRVGEVILQETEDDWLVMTVRLNPADMEKWGHPLVPFQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1A3</accession>
    <name>A0A398D1A3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_03185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04954">
        <property type="protein sequence ID" value="RIE04954"/>
        <property type="gene ID" value="D3H35_03185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="218"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="528" mass="59819" checksum="C6223B6C14649230" modified="2018-12-05" version="1">MNEYGPTENSVVTSYLRHVERALKLTIGSPIANTKVHIVDAGGRLLQPIGVPGELCISGAGLARGYLNQPELTAEKFVANPFAPGERMYRTGDLARWLPDGNIEYLGRIDEQVKVRGHRIELGEVESALRSHESVKEATVIARKDEEGSAYLCAYFVANGNLGAAELRKHLLEMLPQYMIPSFFVRVEQMPLTPNGKLDRKALPSPEGTLERGTVYEAPRNALEETLANIWQGVLGVSAIGITDNFFELGGHSLKATTLVSRIHKELNVQVPLREVFQSPTIKELAQAIRGMEAHAYASIEPAPLREYYPVSSAQKRMYILSQLQGAEQSYNMPGAVMMEGKVDRERFERAFRQLIARHEALRTSFEWVEGEPAQRIHLEVDFEISYKKAEEDGLRQIAEFIRAFDLGQAPLLRVGLLELEPERQVLLYDMHHIISDGVSMDILVREFVGLYGGQTLPAPRLQYKDYAVWQQAFMQSEAMKRQETYWLETFSGNCRYWRCRRIIRDRRFKASKGIKSNLCWTGSCRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1W1</accession>
    <name>A0A398D1W1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_02890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05094">
        <property type="protein sequence ID" value="RIE05094"/>
        <property type="gene ID" value="D3H35_02890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="24"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="173"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="346" mass="36599" checksum="7D4DE9AB04A006BA" modified="2018-12-05" version="1">MKALVYTAPEVMELMDCPVPEPGPDEVLIRVAYSGICGSELSGFLGHNSLRKPPMIFGHELSGIIEDAGASGESHGLRRGMRVTANPLVTCGRCSYCLGGQESLCPERKLLSAALPGSNAEFVKLPAEFVHPLPDHVTLTDGALTEPVACGARVAELTAAGPEDTVLVMGMGPIGVFALQAVLLSGAGRVIAVDLSDDRLSFASSLGAIAVNPRTEDLAARVRELTDGRGVSAAIDAVGAAATRRQCAESVMTGGRLIFTGLHQADTALDFNDLVRRELKIIGSFAYSKANFRQALDWIAEGRIGLGDRMEIAPLADGAVWFDKLIRAPGREIKVLLKISELQDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D220</accession>
    <name>A0A398D220_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05154">
        <property type="protein sequence ID" value="RIE05154"/>
        <property type="gene ID" value="D3H35_01935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="434" mass="47705" checksum="AFFBD25B457AE585" modified="2018-12-05" version="1">MTFHGAGATDTTGSQPLAYEFAVNCDAVGIDAYGTFWPVIMRRYCSHYVTERCKLTNPTEVIIGGTGYLTQQIYCLYGHVRDCLTSNGRHLNDFTGSAYCYVENCHADGDDLGAYVTHGQYEHDLTYVGNSGLMSFGNSGPTWGESAKRITVKKHVGSWFLAFRKITDLTLEDVHVFVREGVENSADTGSFWLNADGLQMKNCTAEAMVKFMQVSSRSKRPNIIENCSFTLTKHRRLSHDNVDAELTFRNCVFDAIDGNRLEGKGGVRFQHCRLNGAGPQSAPIRVAGEMLSVRGGSMRDTGFMLIGDGAQRVDVGSGAVVSGTNSERAFFRRDGLDGGAAEWRLFDYTSRAEDSVTRHYTIGGKSNTYVANGATFEGGRFEAALGAFEDGGYMLHAANVELDVDRNGLPEQNDRIKHLDGNLIIDSRKERMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D240</accession>
    <name>A0A398D240_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_02050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05174">
        <property type="protein sequence ID" value="RIE05174"/>
        <property type="gene ID" value="D3H35_02050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="7">
        <location>
            <begin position="117"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE05174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="563" mass="62673" checksum="4960EA46D355396C" modified="2018-12-05" version="1">MQKKRYTVDAVRKLRTRKSTGRVDMKAKNKMIKGLTAILTAAFVLAGCQSGNEPTSAEASASAAAGTPTAGGQLNFALSTVIANDILDPQKTGSPQNSRIQRNIFDSLVEEQPDHTFKPWLATDWEIAPDNKSYTFHLRKDVKFHDGTPFNAEAVKFNFDRIGKLEAPGVAKNDIGSYTSSEVIDEYTIKIHFATPFAPFLTNLSKENLGIISPAAVQKYGDEFSHHPVGTGPFRFVSYTAGTEYVLEKNPDYNWPPSSAKHTGAAYLDKIVVKVIPEEATRVGVLQSGDVQAADIIPPQNIVSFKSDPNFQIYQAEMLNYNPAIHLNSKRPLLTDVKVREALRTSLDLDSIVKTVYLGTYDRAYTYLSPSLLGSDASLKDEWKSSIEDAGKALDELGWKKGSDGIRVKDGKRLSLEMIDFYANREKRMDVMALVQNQWKKNGIELKITSLSVGAYTERSKTGDFDLWIGSQYGADPDVFRSVANYFDFNDPELAKLLDQAYGELDREKRVAIYKQAQKRIFDQATVIPVYVFPYTVGASKSLQGLAFDAHGFPLFYDAWLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D2P1</accession>
    <name>A0A398D2P1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spore coat protein CotH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_00705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05344">
        <property type="protein sequence ID" value="RIE05344"/>
        <property type="gene ID" value="D3H35_00705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050">
        <property type="entry name" value="PTHR40050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0946">Virion</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017387542" evidence="3">
        <location>
            <begin position="36"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="594" mass="63000" checksum="E4774CB0D770702F" modified="2018-12-05" version="1">MRNKWALPMVSAFFAVLLVVGIVWNGSISDNGADGKQAGATVSENTQKIEENVFPRNKVVDVKITIDKEEFQDMLDNASAEELHSASVEYNGIRMDNVGIRTKGNLSLRSVVNSDSDRYSFKLSFDEYIDSQTMYGISKINLNNNYSDATYMREFLTYELAAEMGLPTPEFSYVNVYVNGELWGFYLAIEQVGDAYLERNFGDSKGSLYKAEFGMGANMNGGDLLWQDDNIESYSALVQKSKKADDDLLIAMLDELNNGTDYEKVLDVENALKYIALNAVTYNMDSYLGSNKQNYYLYEDDGIFSVLPWDYNMAFGGMGGGGGSSILIDEPTQGAVSERPLVSKLLAVDKYKTNYHEIIAKMIEGYLSDDKFEARVKEIQELISPYVKQDPRPFYTYDQYESAIPQLVSFTSNVVTSVSGQLDGTSASSGDGSGSGGGMGGPGGGFGGFGGEQGGQGGPMGQAAPGNTGNGQNGQAVPGNTENGQNGQAAPGNAGNRQNGQAAPGNAGDGQTGQAAPNGQMPGGGLGDFGGMGGGPGGMGGFPGGMGGGPGGFGMPDQGQAQTTGSSDAFFTTLIALAALGLTGLFVTFYKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDB0</accession>
    <name>A0A398CDB0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00683">
        <property type="protein sequence ID" value="RIE00683"/>
        <property type="gene ID" value="D3H35_27380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013378">
        <property type="entry name" value="Listeria/Bacterioides_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042229">
        <property type="entry name" value="Listeria/Bacterioides_rpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09479">
        <property type="entry name" value="Flg_new"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="199" mass="21169" checksum="00E322E84637822F" modified="2018-12-05" version="1">MSARYFKFVITQGKQAQTVLYELKILGNPVFTYEQAVKYDEPVAKLTVTFDSNGGTSVAPIKVKPGTAAAAPTPPAKVGYTFVEWQLNGAAFDFATPITTDLQLKAVWKLNATPTTPTPTPTPTPEPETDTKAVVTADQFKPQGENGNVSVTVKAGVTDIELPVNSGELLQGKLLELHTGDVTLFADACASGAVEERLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDC7</accession>
    <name>A0A398CDC7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_26230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00700">
        <property type="protein sequence ID" value="RIE00700"/>
        <property type="gene ID" value="D3H35_26230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="113" mass="11696" checksum="82A2960F73275AB6" modified="2018-12-05" version="1">MIRNPMASPDVLGVTGGASSAAVCFLSYFAGTVSIRFLPVAAMLGAAIVTVALYSLAWKRGVTPLRLVLVGVGLSAILSGITDDDGAVQSEERGDQAYVWLTGSVYGRIGRTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDC9</accession>
    <name>A0A398CDC9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-ribulose-5-phosphate 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00425">
        <property type="protein sequence ID" value="RIE00425"/>
        <property type="gene ID" value="D3H35_28875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="7"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="231" mass="25661" checksum="B66DD8CC879F1D13" modified="2018-12-05" version="1">MLEQLKDEVYQANLELPKHGLVKFTWGNASAIDRESGLFVIKPSGVSYENMKPGDMVVVDLDGNVVEGVLRPSSDTATHAVLYKHFPEIGGIVHTHSTWATIWAQAGLDVPVMGTTHADTFYGAVPCARFLNQKEIDRGYEAETGRVIIETFKERGLNVMAIPAILLQGHAPFTWGEDVKSAIVNSVVLEEVCKMNLYARQLNHFAKELPPGILDKHYLRKHGNDAYYGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CED3</accession>
    <name>A0A398CED3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_25835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00990">
        <property type="protein sequence ID" value="RIE00990"/>
        <property type="gene ID" value="D3H35_25835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="190" mass="20882" checksum="90FA1B57642E69A4" modified="2018-12-05" version="1">MRSFLHFLGRGWLRFSGAVRHGVRSHQQSAGCVRPDADPLVQRAEILAFHSCGCAVWKGIGYGAVIYYAALMGIDAEYYEAARIDGAGKIRQAMSISVPMIMPIIVMLTILQIGKILYGDFGLFYNVTLNSSLLYPATDVIDTFVYRSLIDLGDFGMASAAGLFQSFVGFILVLATNFIVKKNNPDHSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEH9</accession>
    <name>A0A398CEH9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01113">
        <property type="protein sequence ID" value="RIE01113"/>
        <property type="gene ID" value="D3H35_22105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="218" mass="23542" checksum="B680A3EF5CB18E18" modified="2018-12-05" version="1">MSKPIIAVVGAGPGVSAAVARKFGSNGFRVALVARNAISLDALATELREQEIETYFVTADASRPESLSDAFRSIREQLGEPDVLLYNAAAISKAAATALDERQLIEDFKVNVVGALTSVKEVVPRFVGRKEGAVLITGGGFALHPHPDYASLSIGKAGVRSLTYSLAQELKPSNVYVGTVTISGFVSPGTYFDPDRMADKYWELYTERNLIEYEYTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEM2</accession>
    <name>A0A398CEM2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_25060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01616">
        <property type="protein sequence ID" value="RIE01616"/>
        <property type="gene ID" value="D3H35_25060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="71"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="295" mass="32741" checksum="655ABEA04ABE7FFA" modified="2018-12-05" version="1">MTRIVRSLNARLHLFMAIPALALFAVFFVTPLVRGINISLTDWNGLTPDYHYIGLDNFIEFFKDDRAIHALRVTLIFGLISPVLLCAMGLLYALLLDRPLVGRGFVRTFVYMPAIISPLIMGYVWLLLINSENGALLEVLEMFHLESWYRDWLGSPDQALGVIIAVNLWQFVGYAMIIFLAGLQGISPEVIEAAKMDGAGYWKTVRYMTIPLLIPAIRINVITNLIGSLAVFDVISALTDGGPGYSTESMSIFIMRSSFNGHTGYATAVAIIMFIVILIPVAAALKLMQKADYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CES3</accession>
    <name>A0A398CES3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01213">
        <property type="protein sequence ID" value="RIE01213"/>
        <property type="gene ID" value="D3H35_22725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="74" mass="8147" checksum="5FB8F0BD9F6ABD94" modified="2018-12-05" version="1">MAMIIHIDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIRLSTLEAICKALECQPGDILEYVNLDGEKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CET1</accession>
    <name>A0A398CET1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exosporium leader peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_23185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01676">
        <property type="protein sequence ID" value="RIE01676"/>
        <property type="gene ID" value="D3H35_23185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021865">
        <property type="entry name" value="Peptidase_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11962">
        <property type="entry name" value="Peptidase_G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101967">
        <property type="entry name" value="SSF101967"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_G2" evidence="2">
        <location>
            <begin position="636"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="827" mass="83191" checksum="FE2AB021CA30E06B" modified="2018-12-05" version="1">MSLGWASHAEGSGTIASAQYSHSEGYLTKSSGSQAHAEGNNTTASGTSSHAEGNNTTASGNYAHAEGDGGVASGQASHVEGLNTKALSYFTHAEGRLSAVLSECGHAEGYGSKVNVTSGSSITPVLNTDLLGASAVTTYAGHAEGFDTLATGAASHAEGASTLASGHQSHTEGNLTVASGAASHAEGGGSFSGYGLKVTAVAGNTLTVGAGHSFAIGQLVGVITITYNGSVYSPVLTTTTVTSANIGTGTVGVGSAANISVGTVLLLFDKLGNGVGGRYAHSEGLATFATGSYSHTEGYNTFSGGSAAHAEGTYSIASADSAHAEGLSTTAAGPASHAQGSISRALTAVSHAEGYGSKVNVTTGQAGIAINNTDLLGTSSVTIYAGHAEGFDTLVTGAASHAEGMSTVASGLAAHAEGYNTRASATYSHAEGSFSAALSVSGHAEGLGSKVLVSTPLMFTPVNNTDLLGTSTISSFAGHAEGTDTLVTGAVGHAEGVSTVSSGTASHAEGQLTTSSGQASHAEGISTSASGIGSHAEGRYTQATQEGSHAEGSSTTASGPHTHAEGLNTVASGYVSHAQGDNTVSNAWASHAEGIGTNTAGFAAAHIMGNYGDANAAGAWFLANGTSSSAKGLATKILSTGAVTSDGVYSSSGADYAEMFEWLDGNPDEEDRVGYFVTLVGDKIRKATSANEYIVGVVSATPSIIGDAGGLRWQSKYVTDDWGRIQYHDVTIPAVYDDNGVEIMEERVERQPVLNPEWDNETPYDAREDRKEWSAVGLMGKLYVRDDGTAETGGFVRPDDEGIATASETGYRVMKRITPNIVQVLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEX0</accession>
    <name>A0A398CEX0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PLDc_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_13025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01726">
        <property type="protein sequence ID" value="RIE01726"/>
        <property type="gene ID" value="D3H35_13025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="PLDc_N" evidence="7">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="68" mass="7685" checksum="58411D214A72E7A4" modified="2018-12-05" version="1">MSLQDVNFQVVLPVLVIQLVLMIIGLVDLWRRESTLTRGPKLLWVFIILLGSILGSVAYFTIGRRSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF31</accession>
    <name>A0A398CF31_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type III PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_22530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01180">
        <property type="protein sequence ID" value="RIE01180"/>
        <property type="gene ID" value="D3H35_22530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="2">
        <location>
            <begin position="23"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="3">
        <location>
            <begin position="28"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="404" mass="46149" checksum="CA37620154203279" modified="2018-12-05" version="1">MSVQVEQWIREWHERGDEPVCAYVYDLAAIQRHVRDMLKTMPEQASLFYAIKANPDKRIIEALLPFVKGFEVASIGELSLVREVSESVPILFGGPGKKDAELETAIRKNVSYIHVESLLELRKIILLAKKWNKHTQVLLRINLRTDTLPRTKITMGGRPSPFGIDESFIEEAVAIIRGEDNPFVHFSGFHFHSLSNNLLAELHADMIRLYLRKAEEWKRAYDLDIRVINAGGGFGVAYDDKPGFDWPKFTSLLTESKALQALGDTQLFFEPGRFIVADYGYYAVEVVDIKQSHDQLFAVVRGGTHHNRLPASWGHNHPFRVVPTDRWEYPFSRPAVHDSKVTIVGELCTPKDRLHTDAELDSLRVGDVLLFEKSGAYCWTISHHDFLGHPHPKFYYITEGNQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF57</accession>
    <name>A0A398CF57_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymuconolactone decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01826">
        <property type="protein sequence ID" value="RIE01826"/>
        <property type="gene ID" value="D3H35_13615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="15"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="157" mass="17738" checksum="23A9394FD59610D0" modified="2018-12-05" version="1">MSLRFNYRAANEPAYQAMRAMEAHISQSGVDKVLYELIKIRVSQINGCSFCLDMHAKDLMKLGDHADRILLIGLWREVPIFTDKEKAVLELAEHVTNISQVGVPQPVYENVRAYFDEKEYIDLIVSINTINSWNRIAIATGMFPAASRNCGFGERGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF62</accession>
    <name>A0A398CF62_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpmE</name>
        <name evidence="8" type="ORF">D3H35_21640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01045">
        <property type="protein sequence ID" value="RIE01045"/>
        <property type="gene ID" value="D3H35_21640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="65" mass="7242" checksum="A27A2B63AD235B38" modified="2018-12-05" version="1">MKASIHPQYHITTATCACGNTFETGSIRSNLKVEICSNCHPFYTGKQKFIDAGGRVDKFKKKYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFG8</accession>
    <name>A0A398CFG8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome bo(3) ubiquinol oxidase subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cytochrome o ubiquinol oxidase subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Oxidase bo(3) subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquinol oxidase polypeptide IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquinol oxidase subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">cyoD</name>
        <name evidence="16" type="ORF">D3H35_14275</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooctamer of two A chains, two B chains, two C chains and two D chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase bacterial subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01936">
        <property type="protein sequence ID" value="RIE01936"/>
        <property type="gene ID" value="D3H35_14275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009486">
        <property type="term" value="F:cytochrome bo3 ubiquinol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005171">
        <property type="entry name" value="Cyt_c_oxidase_su4_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014210">
        <property type="entry name" value="Cyt_o_ubiqinol_oxidase_su4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03626">
        <property type="entry name" value="COX4_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02847">
        <property type="entry name" value="CyoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RIE01936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="111" mass="12542" checksum="9D6FFBF46E70CE74" modified="2018-12-05" version="1">MAQHSEHTHGHEDEHEAHGSLKSYVIGFLFSLILTIIPLVLVLNDWVEGTAAYVVLIGSAVLQFVVQLFFFMHLKEEKKPRYNLMVLIFGLVILVTIVGGSMWIMTYNKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFS3</accession>
    <name>A0A398CFS3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_26530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00752">
        <property type="protein sequence ID" value="RIE00752"/>
        <property type="gene ID" value="D3H35_26530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017482632" evidence="5">
        <location>
            <begin position="38"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="322" mass="35146" checksum="54ACA1C8C33F3A09" modified="2018-12-05" version="1">MKMNTKTSGAIVRAFMIAMLAAAISLLSACGKSSNGAVTGKVNVVTSFYPLYFLANEIGGEDAHVVNLIPAGVEPHDWTPKSRDLITVGDAQLFLYNGAGLEGWLDDFLHGLDSSGKTLTVEASKGIALIQGNPEEENHEEEHEAHGDSDVDPHTWVSPKSALVMAKNVLDAFIQADAVHRSGYEERYASLEAKLAKLDDQFETGLSALPNKNIVVSHQAFGYLARDYGLNQVAIMGLSPEAEPRSQDLLKVVEFVKEHKVKVIFFEELVSDRLAKTLASEAKVETMVLNPLEGLTPQQEKAGDDFITIMERNLQNLRQALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFW3</accession>
    <name>A0A398CFW3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">greA</name>
        <name evidence="11" type="ORF">D3H35_23410</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the GreA/GreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01325">
        <property type="protein sequence ID" value="RIE01325"/>
        <property type="gene ID" value="D3H35_23410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="10">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="9">
        <location>
            <begin position="85"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE01325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="158" mass="17596" checksum="8EE0738F441BCB7E" modified="2018-12-05" version="1">MSDKEVLLTPDGLKRLEEELENLKSVKRREVAERIKVAIGYGDISENSEYEDAKNEQAFIEGRIITLEKMLRNARIINNDEIDLDTVSIGSTVVVEDLEFGDSMEYTIVGTAESDPLKNKISNESPVGRAILGKKKGTTVEVNVPAGIIQYKIVDIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG19</accession>
    <name>A0A398CG19_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="3">2.7.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Flavin transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_26020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000045">
        <property type="protein sequence ID" value="RIE00872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00872">
        <property type="protein sequence ID" value="RIE00872"/>
        <property type="gene ID" value="D3H35_26020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE00872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="196" mass="21024" checksum="6126F7FC66BB402D" modified="2018-12-05" version="1">MELRGWQLFPRAGLVRLRRGTRLDLGGIAKGWTVDRVSEGLIGRRIRAGQLNAGGDLRVWSEPGLPAWEIEAALPDGFASNAPSFRFALRNGAAATSSTLRRQWATPGGNRHHLIDPRSGLPAASDTVQCTVVGTTAAEAEIAAKTVLLLGSEDGLRWLERTFPLCDALLYKQDGTAIGVFGKHGDAEWKEGGGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG53</accession>
    <name>A0A398CG53_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01480">
        <property type="protein sequence ID" value="RIE01480"/>
        <property type="gene ID" value="D3H35_24305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="13"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="269" mass="29914" checksum="8DDFBCCAA6A67A37" modified="2018-12-05" version="1">MGLRFTVLGSGSTGNATVVKTDETTVLVDAGLSCRRLEELMKERDVSGAQVDALFVTHEHSDHIKGLGAFARKYKLPVYANEKTWYAMRKLIGDVPDVQRKVLPAGGVLEIADLRIESYPISHDAAEPVGYCFHQDGVKLSLATDLGYVSDKVMQQLQQSNVLVLESNHDVEMLRVGRYPWNIKRRILGDTGHLSNEAAGAALCDLLTGTTRRVYLAHLSQEHNLMDLAKLTVNRVLEDNGIFFQKHEFALCDTYADRPTEWDVVKATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGE9</accession>
    <name>A0A398CGE9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_24595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01535">
        <property type="protein sequence ID" value="RIE01535"/>
        <property type="gene ID" value="D3H35_24595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="281"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="373" mass="39715" checksum="FD157CE5CCBBA08A" modified="2018-12-05" version="1">MFLAIKELMHNKTRFLMLAIIFVLVSWLVFILSGLGNGLASLSASTIKHMKVEYVVFEQGSQSSLSKSLLSEELVKVAAQQPNVKAAAPLGTTMATALKGQSEKDEDKLDIAIIGIAPGSFLQPKIVEGEGLSGDKPTGVLVNISMKDEGFSIGDTFKLDGSTESLTIVGYVNGETYNHVASVFTPIDEWRKIAFAAPGSDNGVAEPINAVMLQGNGIHPSDLNGKLPNTNTVNRAAAIQGMPGYKEESGSITMMLAFLLTISAFVLGVFFYVLTLQKSNQFGIMKAIGARNGFLAKAIISQVLLLSVGSILIGILLTYAAATVLPQAMPFILSTRLVVIYAIVLVIIALLSSLVSVRKITKVDPLKALGRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGQ1</accession>
    <name>A0A398CGQ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_22220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01132">
        <property type="protein sequence ID" value="RIE01132"/>
        <property type="gene ID" value="D3H35_22220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="172"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="274"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="535" mass="60055" checksum="2C4ABCBB9CF505DE" modified="2018-12-05" version="1">MSDSISSSARTLCLLLDSIEYKTIDRVWHPERKPGMYMLIAVASGQGALDIAGANFRLKQGHGCLIEPDLSAAIGGAPERAIQAYLLGFRKLRTGDDSSIHEHAFEIPAAVCSSVPLSAEAMFVLQDLLEHKDDNQPHQQLKNHIRFQQFMLPILFPPAQDGYARHSRDAVREVISDLDNSFVDPVDIDGLAQRSGIGKRYFNQLFRELTGTSVTEYVTSLRMNSALRLLSRSDANVKDVARTVGYSDEYYFNRRFKMTYGIAPGQYSRSETRRSKLFATQYLGHLLTLGVKPVGATSNIMTHSFLRKLVAGIESVDILPSSPSRVSELMPDLIIGCEQSDKDLYASIAPVMVMPYGERDAVYQLERLAEMLDKQKEAKRWKEAYERKSMRLKRSLDGTIGRSETVSVIEIWEEGIFAYGNRWGRGGYNLYNALELKAPAPVERHLIDNEPYRRIELEELPDYAGDHVFLTVYAEGGGERRANEIKRSAIWRSLPAVIRNRVYEADISLFGPGDPISLGKQLDIQVGMLLAGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGT4</accession>
    <name>A0A398CGT4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_23500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01680">
        <property type="protein sequence ID" value="RIE01680"/>
        <property type="gene ID" value="D3H35_23500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="300" mass="33569" checksum="5E74F54AF56AF9B7" modified="2018-12-05" version="1">MPSGTTVKGIWNGRIYRLERLLGTGANGHVYLAANGRSQYAMKLGFEVTDLQGEANVLASLDHAERGRPPFLLDVDDFELNGRKVPFYVMRVVPGMPASAYLSKRGSEWLGVIGHRLLERLSQLHDAGWVFGDIKNENVLVHDYGKVGLVDYGGVTAIGRSVRQFTEIYDRGYWSAGSRTAEPSYDWFAAAMLWVHATDGKRLIRLTETLLPQNRHPRELLKLVRTNPHLRPVETWMERAFAGQFQDTADACLHWRSCLRQADRDALAASGGKVMGWMTGLFAASLVLFVSAAAVWLLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGX2</accession>
    <name>A0A398CGX2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF817 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01212">
        <property type="protein sequence ID" value="RIE01212"/>
        <property type="gene ID" value="D3H35_22720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008535">
        <property type="entry name" value="DUF817"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05675">
        <property type="entry name" value="DUF817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009141">
        <property type="entry name" value="UCP009141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="263" mass="30452" checksum="EFF9A7AF637BD3BB" modified="2018-12-05" version="1">MKAALRQFIRFGWEQALSCLFPVVIFASLAVTQLIQIPWLPRYDLLLLICLAMQGWMVHSGLETRDEVKVITMFHLIGLALELFKVHMGSWSYPEEGYSKVFGVPLYSGFMYASVASYLCQAWRRLKVELIKWPPFSVVVPLAAMIYLNFFSHHYWIDARWWLSALVLLVFWRTWVTYEVGGTRYRMPLALSFVLIGLFIWIAENVATFFGAWEYPDQSVSWRIVHFGKVSSWLLLVIVSFLIVATLKLVKDRQAPVQLGIMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHD7</accession>
    <name>A0A398CHD7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_18210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02616">
        <property type="protein sequence ID" value="RIE02616"/>
        <property type="gene ID" value="D3H35_18210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="32"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="5">
        <location>
            <begin position="113"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="199"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="259" mass="29438" checksum="8847C9098D7AE8DC" modified="2018-12-05" version="1">MNPAGSARLPDDAISVLIEYQTTFDEELADQLIRHFEPLVKMAANKMSRNRPDLFDDLFQVGQMSLFRLLKQFDPKLGMPFEPYAMKSIIGHMKNYLRDKSWYIQVPRRIKEKGLAVQQTIDELTLILERSPNVEEIAAHLELEVEETLEILAGRDLYHYVSLDTPTSDDENTAVLGDMIGAPSDDFTALERKIDLDEALSKLKPEERQVLQLVFAGGLSQRSIADRLSVSQMSVSRIQKRAIEKMKELLNEQTGEEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHT4</accession>
    <name>A0A398CHT4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02353">
        <property type="protein sequence ID" value="RIE02353"/>
        <property type="gene ID" value="D3H35_16700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901575">
        <property type="term" value="P:organic substance catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="361"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="669" mass="74078" checksum="DD4038CAC4FF3131" modified="2018-12-05" version="1">MSSYLEKKPYLVDAVVGNSRFLASLLHTGRIVRFWWPHVDFPQHADTLRSGIRLAGHERTSWFDGTGDGWNHSSAYVPKTNIFSVTAESGSIPVKVQSETYAVPGEDLLILDYQLTNTSDQAISFSFSFYSSIAVAESPFYQTTQFHHGSDSIVHFRHDHYFAVSSANVCAKYQAGHAWDNANSGSLNGDDIQMASDSAMDWSFDNVAPGQTVRHTVYLAAAHKLDDAAALLGKAKEIGIDAWRESTSRYWIDFVATASSCPINRPDLQELYERSVLTMKLMSDEKTGSIIAAPEFDERFSVCGGYAYCWGRDAAFITTALDKAGLLDMSTRFYEWTLTAQDSDGAWQQRHYHDGSIAPSWGLQIDEGSSILWGMYQHYLALPANSREEFLKLVWDAVRSGAEFLTSSINESNGLPIASKDLWEEREGQHTYSSAAVYAGLKAAASFAGLVRESELEAKWAGIADGISKQIVSLCWNEEQGVFYRGVQLTVDKYKYEQAANAGLPVSEIVDGKGYSRYRLGFDPIVDVSLLGISVPFDVVSPDNRQAVLTADAVERALTVPGVGGIKRYEDDNYIGGNPWILTTLWLAQYRARNGQVSEAEKLLEWSVEHRTSSGLLPEQVDKNSGETAWVVPLTWSHAMFILTVHLIADARNAESSHAQNEPSAQILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI51</accession>
    <name>A0A398CI51_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_20280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02946">
        <property type="protein sequence ID" value="RIE02946"/>
        <property type="gene ID" value="D3H35_20280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="2991"/>
            <end position="3052"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="3053"/>
            <end position="3116"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="3124"/>
            <end position="3186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2745"/>
            <end position="2767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="3186" mass="319361" checksum="F360DFCEA90A29DE" modified="2018-12-05" version="1">MNDGTTDFQGKILEVDRDLALSPYSWVPIGTDGSPFRGVLIAKGGGPFSISDIKVSGSYGYAGFIGSMENATIGGFTLSGTVNVNAAGDLYAGGIAGTVTSSGGSNSYIYDVTNFINLNLTATNGVFAGGIAGSASGTISNAANKGTVEVAAAVSGSSAGGIAGINSGELVLKTVSNTAAVSSKAAATSVAGGILGQAGADLLMADGHTAVVNSGSVTAEEGTNVYSGGIVGRLASAAASATFSNNTANSGKVEASSANSTESYAGSLAALIERDFEVDFNFISTGQVVNHAKDYVYTGGLAGRVKGSLTLSRNYKQTAAVEASASGTEYAYTGAVAGYVDGDISAASGFSLKNEAALRVVGSAASHVYTGGLFGAADGTVAFDSTLPGAYANSGDIEVTGRSDVYTGGIIAAQAYGKAADNVLSAGNITVTGEKALYTGGYIGKVAGAAADLKGEKYARRIVVNGNATLNTDLASGIFTGGIVGFYETSGVLEEAAFTGEIAAAGGEYTYTGGVAGYLGAGTVKNVQAGNTAAAYASIASTGSAGGVAGYAAGAIESSNPQYISVAAQGQDGLPGRAGAIAGETALAASIGSPSSPLGVKNVSVTSEGDHTRLGGAVGENRSSSVYIVLPLDDADELTVASDGDDSAIGGVFGKNSAPLAAANLSRVANIKVMSGGRNAIVGGIIGDNYGVLDSLGIRNPDVSSEGQGTMAGLLAGRSSGSIVHPEVFGEDSGIPKLAVSGRQSVAGGIVGFLDNAAITGNGTDADIADVRIAATGEDSAAGGIAGKSRSSDVQSVIVDSPVITISGNGSTAGGITGEATGEQRHIADSAVLRPLITANGDNSKAGGIAGYTEVEIADSSIAAYDGEYSVLKVGGSGSFAGGIAAKAIGVSISGDAQSNNIESLLINVLATADGATVGGAVGWNEGTSVRKLYADSVKMTVSAPNAKAGGLAGYNKGTETAVIADNYMSEVQLTAASTAGNSTLGGIVGLNDGRDGSLDSGDPKTAVSSIRNNRILGSLTVNSPDSKVGGLAGENRSVVANNSISDGFRVSSQGSGNTVGGLVGLNTKTVFYSFSNAGLTLGGSRVAAGGLVGENTGLVSSSYIAKDVTAQISGTSSAYAYLGGLIGKNSGIVEKSYTSSVVTANGAYVCVGGLTGWQAGGSVTSSYAAKNVLAKGSSSFSGGLLGRITAGTIGDSYSAGRISGASGAYSGGFAGRYDTANKELLNNSYYVKDESLGINSGLLDFAAGNYYELKLYMRLSPILSASLADREAFKTLSGWDFSSQNRLWKYGSSQAEYAYPELVLDANSGGGSPQTDVGTNISWYTQHKDELRFYIDSEAELAGLAAIVNGSVTGLPKFDFAGRVVEVTAPVTIQSAQWAPVGNSEENAFQGSFDGGNHLISGLRADGQDFTGLFGVIGNRGEVRNVKLAPVSVTGTGSVGGLAGLNKGSIAQVEVILADGAYVSGGDRAGGVAGESRGTVRDVAVTVDSSGEVRSETVGAAVGGVIGEASAGSLADANIALNGGQIKGTGSGSSSGGAVGVSGAGHSISGIRLLADNAGVVNPVNITGHGNAGGIAGDKKGKGIAEWDVADVTVEHVVISSGNGGNAGGIVGTVENGAVRNAVFAGAIRISADGVSAGGLAGKSLNSILYKGKATPELTLSTTSEESYVGGLAGIIENTGSDTAFDFGKLLPVYRGITLSESEGGTISVQATGYRADVSVGGVAGKNASSSVYETSSDTKLEATGVRTVNIGGIAGWNEGDIIGGTAASDITASDSGIYNAGGVVGFTSGGRIVYSRADGGKAIAIGSAAAIQQVTPATYAGGFAGRAADTTIRNSSADSVVTVYCDNAHNTVYAGGFAGLLQSGIYGSGTIKRSYAQGSVTVSGKSGSYAGGFAGSIEGYVIEEAYASATVANTAFDARSGGFAGVIEQSATIEQAYAVTSSVEAKGSHGATRAYAGGFAGYNNGSLTETYASALRVASVANGSNSYVGSFIGYNFRDGQVNGSYYADAGKAGIGHGTSAQSLEPVDFSGRQPLAGWDFSTDDAHWAYLAGVNGDKPVLRNITNWTFAPDLTFLMEAESVDELVIFSERQLGAAVLLSNDEDLSFYRLYDKAATQKPRLSKLRLEADLNLSGSLWIPFEQFEGVFDGNGKTIAGMSYYGMDYDRYGFVRSNKGTISNIAFKDARIEAGGDVGIVAGENAESAVISTITISGEVAGSGDYVGGAAGKSEGSLTGITVRGLRVDGRHYVGGVAGAAAGISTVTAEDVTVKGQSFLGGAVGKATGLVRDITARNVTVEAAAGTAAGIVPENEHGVQNVKLSGAAVTGSGLVGGIVGKSSSVISDASVQGELLAHGGVVGGIAGSNEGTIENSRFNGLIAGTGQAAGGIAGDNGARITESYATGSVELEAADAQVKVGGIAGTNGSAAIVEESFSSASVRARGDNASAGGIAGENEGSLRGVLNAGNIEASGASYARAGGVAGYALAGSINNALSYGQVEGSINGRMVYKKTFYGGIAGQAEEQASFENSYSDRQMLKEIIAYSDSSGHFVRSVQGKAVNAGTAALTEGDLPAGLDDQVWRAQAGFYPRLIAFDGVDTAKLAAAAVKLNERDTAYDVKSDYVLTQDSSIVWSTVRNGGVILLTASLQQESRTIAVNKPALMYADTAGKPSGLTDSTFKESVQVSLTTDEAGGVIHYTLDGSLPTEESPVYDGELTLSKTTTVRAIVKVEGKNDSDAAQAVYTKEAVSGGEGGGGFPAGGGATVPPTDSDTEIWVNGKAENVGTEKASSEGGRVTTTISVNEEAMNKLLQTYGDNAEIAVVFNKKSEVSAAELSAQLVKAMADTKAFLKVDIGNVAYRIPAAQLYQEAILQRLGGQAAAAADVRVRIEISIPEQARQLEQAASNGGYTFVVPPTAFKVTYALGSTVAEASLYDAYVERSFVLSSSAPEASGMAGVSVAEDGTVSPVPTRFSVSGGTKAAVMKSLASGGTFAIVSSEANFRDLSAHWAKQAINDLGVRLILNGTGTGLFEPNRSITRAEFAAIAVKALGLQGVSSTGSALFTDVKAADWYAPYVGIAYQFGLISGYSDGSFGGKNSISREQAMVIIARAMKLAGLQATVTEAEAQQLLASFADADEISGYAKADIAASVKAGLVSGRSGAEGTAISPGEQMTRAEVAAIIRNLLNLSGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CID4</accession>
    <name>A0A398CID4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF523 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00949">
        <property type="protein sequence ID" value="RIE00949"/>
        <property type="gene ID" value="D3H35_25655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007553">
        <property type="entry name" value="2-thiour_desulf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04463">
        <property type="entry name" value="2-thiour_desulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="156" mass="16875" checksum="2BCDBA812AB71349" modified="2018-12-05" version="1">MSKKILVSACLLGQKVRYDNGDVPCLDPRFLKWYEEGRFVSICPEVVGGLPTPRPDAQRQGDRVVTGAGADVTEPFAKGANAALKLANEHDVALAILKQDSPSCGSLFIYDGTFTDTVVAGEGTTTELLRRNGFKVFGEDQLDEIERELALVDGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIE2</accession>
    <name>A0A398CIE2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_25705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00959">
        <property type="protein sequence ID" value="RIE00959"/>
        <property type="gene ID" value="D3H35_25705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10315">
        <property type="entry name" value="CBM41_pullulanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005323">
        <property type="entry name" value="CBM41_pullulanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM_fam20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03714">
        <property type="entry name" value="PUD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017316979" evidence="2">
        <location>
            <begin position="35"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="4">
        <location>
            <begin position="231"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="825"/>
            <end position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1512" mass="165369" checksum="5331C09EB004A038" modified="2018-12-05" version="1">MEAIRIMRKMQHPIISAMLALAILVSLFSTGAPAARAEVQQLQSPVIGALNADGKGSSVTFNYQALPADENVNVKGSFYKNWAETIPLVKGDNNVWSLTREIPAGWYQYGISVGNDWKGDDLNLVRNDSNPGLSVPGIKFNASEEVELDSETALSADYYTGVTDTKHAAALSIEPKTGVSIEDGMLKVTNEATPGNVTVTATYVVNSVTVTATQSINIVGELLKSPVINGDGTVTFNNKTHTGDNLYLVGDMNGWDKDAPLPFTKNEGIFSLTLPLEPGKYGYKFLITSGSYNGSFTDPLNPVIADTNSILIIQGIKINSANDIVKGSSIPLTADLVGPAGDAAAVTPTWSLKEEKAGISIANSTLTVDSDYVVPANDFVTVVATLDGKTAEKKINITDKLYTFNIKYYRLDQVLTNWDNWIFRAGMAGTEYDFTGVDSNHFATVAVKLPYTSIKTIQRPGQWTEQDLEHEIFIPEGQDSVDVWIVEGKPDVYYSESEALDIIAQTPVPVKRYIDLTYVRADEDYTDWNLWVWSTGKKNDQILFNSVADGVAKARIEIGALTKRIGFKVRKGDWVETDVNADRYIDAPLEQALTKVIVTSGELAIYSIPSVNGPYLDNGGVTFYYRDDGLYGENEMNTIDSVKVKVTVNGDTQEYPMTYNAKNEYFEYKLPALQEGNYTYSFLVTKDEATTEKNDPRNTVNGVSAFEYRSPEVNVTATAAPNAISSNENAVLSVNLSSTLQGLKYREIFADLSTLGGTSKMPIDLDLRKGTIGVTDSVSAGVKTIALTAVDQYGNKHTGTASIQVKPRQSVGKLDFDWDEARIYFLLTDRFFDGDSTNNADVDKTNLEAYHGGDFKGLIEKLDYIKDLGINTIWISPIVDNIDFNQGVGFGGKQYGYHGYWAKNFETIDEHLGDLDTFKQLLDTAHDKGIKVMVDVVLNHTGYGLKPGDTNNQVEQADKDRFSGMLRTNGVDSGTDEVKGELAGLPDLITEDPAVREKIIDWQAGWLERAKTDRGDMIDYFRVDTIKHVEDTTWRAFKNALTEINPEFKMIGEYYGASIDATGGALRTGQMDSLLDFDFKDRAEQFVESGKINEVEEYLEHRNALIDNTTTMGQFLSSHDEDGFLSNRVGGDKGMLKVAAALQITSKGQPVIYYGEELGQSGKKSGNLAEGQLSENRKDMPWDKVSEEQALHDHYKKLLNIRAEYSKVFSKGTRTKVAGSDSDGYLVFDRAYENRHVLVGLNTTSTEKTVTIEVPFEAGIKVTDLYDNNTLYTVSNDHKVTIQLPSRDNGGTFILAAAYELELASAAVSVTGTEISMQFNRPLDHEVALAANQFELVNTAATVASAEYTGSDNKTITLHLNGKIYLNEEPTLGYSGIIGQSNEKLAPESSSLLENGSTVKALTVGTPQFKNLAGDPVTTLTNNGFIKVTVGITNHSVNGEDGTLIVVLKNAGGDVVNAAYVEKSISGGGTETLTAGFKLPNTVTGYYIEVFVWDTLDGMQPLSNKITFPQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIG8</accession>
    <name>A0A398CIG8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GGDEF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_27115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00638">
        <property type="protein sequence ID" value="RIE00638"/>
        <property type="gene ID" value="D3H35_27115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="230"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="379" mass="41668" checksum="49176EE281786B7B" modified="2018-12-05" version="1">MLFMSFRLYARNRRAAFRSLLVSLGFILVHHSLQLALSVGLVPVSTILAFVGKLLQVFAFIVINFAVFELYHKKRSRTKLWFYGLLVFGVMIAIAGLLPGSSSQDYTLEAAMSRTPALDGYLLVLSPLFALMLAPHVGQRFKYAASLIVAFAAQLSEIAIGYWEPDSAALDTLSGLLPVFYYVLLFMVLFERVVELLQTAYRSSITDGLTNLYNRRFFSGQLDRALRSGKPVGVIFCDIDNFKRLNDTQGHHKADGVLKQVAAILMEETDGIGLSGRYGGEELVAFVNGPTQTVFQTAESIRLRTEKESIVTISVGFSLSDPDDSTVPGYGETLLKQADQAMYHSKTSGKNRVTDYATISSRTGQSLIASPSGGKGVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIL8</accession>
    <name>A0A398CIL8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02225">
        <property type="protein sequence ID" value="RIE02225"/>
        <property type="gene ID" value="D3H35_15935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="187" mass="19920" checksum="06C4390B0DC34AE9" modified="2018-12-05" version="1">MPIHIKQRTDERGLSRSSRATAARLARITVGAIAPATFYLTAATPVFAAQKSEELRTSAADAAIGTLPLLAAFGVGIAVAVFAVVAFLQMTARGRSDGLYPAYAEGAGSSSDDVSYMEWNDSSATSGVSSNKMEEDTDSVPLEDFEQTAFYTLPLPRVHTPRLTKRLRTRSLAYADSKENSPAPASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ06</accession>
    <name>A0A398CJ06_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_15080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02082">
        <property type="protein sequence ID" value="RIE02082"/>
        <property type="gene ID" value="D3H35_15080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10147">
        <property type="entry name" value="Wzt_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029439">
        <property type="entry name" value="Wzt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14524">
        <property type="entry name" value="Wzt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="24"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="62"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="428" mass="47538" checksum="F8E27CFE44FE2896" modified="2018-12-05" version="1">MDSASPIVLNNVSKVYRLYDKPTDRLKEAVFPFGNNRYHKQFSALSGITFEVGKGETIGIVGKNGSGKSTLLKLITGVLTATSGSIAVAGRISAILELGAGFNQEYTGIENIFLNGTILGYSRDEIENRLDDIIAFADIGDFIYQPVKTYSSGMFSRLAFAVAINVDPDILIVDEALAVGDVKFQTKCFNRFKALKDKGVTILFVGHDIFSVRSFCDKAMWLHEGELLRYGDTLSVTAEYMQFMNQDSQQSSDKHDDLTKNASIEALEAEVEIPFDAINRWGSNIGLIRTGLIRGIKSELSNVLISGERARVTVGFHIPPDIDTSILHIAFSIKNTLGIDVLVSTTYENESFRLERRNGLVEVNFEFDNYLNQGDYILVVALEDRTNPVTEYFDYVEGAQYFKIVTKKKAYGVLNIPVVQYLNANGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ91</accession>
    <name>A0A398CJ91_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pilus assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00898">
        <property type="protein sequence ID" value="RIE00898"/>
        <property type="gene ID" value="D3H35_25325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="293" mass="32339" checksum="5845A66BF6322656" modified="2018-12-05" version="1">MEAALVVPIFLTVAFVLVFLIQTSITVMALHSALSQTARQAASAWYPISLGMDKARDNQIYSQAEEWRGRLTDIGETIGEYGDYLPEPLKGWARDAADGARNAANYPVREATERWVRSSADDGMIDKNRIRITEAQVPAEDFSETAFLTLSAEYRLPFRIPFTNRPITIRETVKERAWIGGKPSTARLVDGEASIGTLSFVSLEPNPVRPGKKATLLLRGKPGEIVDLNVLYKSGPSEAKHLGSVTVDSSGFVQWTWHVSGRTTPGEWVWEAASGDGSRLKQTFQVKKRGANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJS3</accession>
    <name>A0A398CJS3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S4 domain-containing protein YaaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yaaA</name>
        <name evidence="1" type="ORF">D3H35_23985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01429">
        <property type="protein sequence ID" value="RIE01429"/>
        <property type="gene ID" value="D3H35_23985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014330">
        <property type="entry name" value="RNA-bd_S4-rel_YaaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02988">
        <property type="entry name" value="YaaA_near_RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="71" mass="7798" checksum="D6AD5A6D4BABED39" modified="2018-12-05" version="1">MKKIAISTEYITLGQLLKLADCIGTGGEAKFFLQETKVLINGEPDNRRGRKVVPGDLVEVEGFSPFTVTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJZ3</accession>
    <name>A0A398CJZ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01178">
        <property type="protein sequence ID" value="RIE01178"/>
        <property type="gene ID" value="D3H35_22520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="96" mass="10761" checksum="CBBA997D3DC153FE" modified="2018-12-05" version="1">MAFMPPFGPQGSPQPPSSPPPQTIPPKPLTSTFAVDPGAIAGCLFRYTYIWPRSGPGFWFYPVFVGRTSISGFRWNGFFWMFSGLDLQRIESFSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK82</accession>
    <name>A0A398CK82_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-layer homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_18845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02710">
        <property type="protein sequence ID" value="RIE02710"/>
        <property type="gene ID" value="D3H35_18845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="53"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="145" mass="15622" checksum="65B3B97ED1B46681" modified="2018-12-05" version="1">MGSHWRSGSSISWLRKDFSAAKPNQPSHPTSGLPGGISLHCSSRDSGLQDEQGASAFRDVKEPSWYAKDVSIATGKGLLTGDPGGSFRPNAPLTRQELAVIIANALRYAKPQEKLAEASLASFTDAYRVPDGPRERCEPLLPRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKH9</accession>
    <name>A0A398CKH9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide pyruvyl transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03816">
        <property type="protein sequence ID" value="RIE03816"/>
        <property type="gene ID" value="D3H35_09695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="14"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="409" mass="44695" checksum="FAFF603300C81DB7" modified="2018-12-05" version="1">MPKFVISGVSGFRNRGVNALVATTVEGIKTIDPAAKITIISDTSDYDVLHGKKLTARFLQDVFRTRRGKLVRKVSLVSKKLANRLSSSFIEAMDAVEDTDIVIASGGDIFSSDYGDQKDFLIPLKIAQKAGKKVVFMGHSIGPFKTRQEADMWLEVANKSVLITVRESLSYQYVCQQLGVPENKVFLTADSAFVLALPEQAQIGRLASFYGIDSGKPLVALSVSQGIIKFSGADAASHFEVWKKIISTLLNDLGAQVLLVPHVQERAAFNDDRIIQSALVKEFDYDDRIKLVSGDHNASELKGLISLADLVIAERMHAGIAGLSSGVPTALIGYSVKARGVIHDIFGEMAEELELLVSVQDLVNGTSTEKWLKGLWSNRAKIAFRLSAELPKFRSLARKNFELLGALLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL02</accession>
    <name>A0A398CL02_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FMN-dependent monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_08610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04006">
        <property type="protein sequence ID" value="RIE04006"/>
        <property type="gene ID" value="D3H35_08610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="146"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="218"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="446" mass="49144" checksum="B807D099BB09C1D1" modified="2018-12-05" version="1">MTKNKKQIKFGALIHGVGGNVSAWRHPEVPADASVNFKFYTEQAQTAEAGKFDLVFIADGLYINEKSIPHFLNRFEPLTILSALAAVTSKIGLVGTLSSSYSEPFTVARQFGSLDHISGGRAGWNVVTSPLEGSAKNFGKPEHPTHDERYRIAEEYLEVTRGLWDSWEDDAFVRNKETGVFFDPSKLHRLNHKGTYFSVEGPLNIARSKQGHPVIFQAGSSESGKNLAAKGADAVFTGHETIEEAKQFYKEVKERTVAAGRSADDVVILPGIGPIIGRTQEEADRKYEEIASLVSIESALNYLGRFFEHHDFSQYPLDEPFPDLGDLGSNSFRSGTDKLKKAAKENGWTLRQVALQSATPRGPFVGTPEYVADLIQQWHEEEAADGFIIHSSIPSGLSDFVNLVVPILQERGLYRTEYESDTLRGNLGLPIPENRYAAAAKVQVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL71</accession>
    <name>A0A398CL71_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribulose 1,5-bisphosphate carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_28595</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RuBisCO large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00381">
        <property type="protein sequence ID" value="RIE00381"/>
        <property type="gene ID" value="D3H35_28595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016984">
        <property type="term" value="F:ribulose-bisphosphate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033966">
        <property type="entry name" value="RuBisCO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020878">
        <property type="entry name" value="RuBisCo_large_chain_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000685">
        <property type="entry name" value="RuBisCO_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036376">
        <property type="entry name" value="RuBisCO_lsu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017443">
        <property type="entry name" value="RuBisCO_lsu_fd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036422">
        <property type="entry name" value="RuBisCO_lsu_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42704">
        <property type="entry name" value="PTHR42704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00016">
        <property type="entry name" value="RuBisCO_large"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02788">
        <property type="entry name" value="RuBisCO_large_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00014">
        <property type="entry name" value="RuBisCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51649">
        <property type="entry name" value="SSF51649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54966">
        <property type="entry name" value="SSF54966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00157">
        <property type="entry name" value="RUBISCO_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RuBisCO_large_N" evidence="8">
        <location>
            <begin position="15"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="RuBisCO_large" evidence="7">
        <location>
            <begin position="138"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE00381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="421" mass="45062" checksum="3E162C898DEA6B30" modified="2018-12-05" version="1">MSANRVKAVYLIETPYTLERAAEVIAGEQSTGTFTAVPGETDLLKEKHAARVESIEELEAAGVPTLPGSKTPQGHDGRYRRGLVTVSFPLHNFGPSIPNLMSAVAGNLYELQELSGIRLVDLELPDDFAARYPGPKFGIEGTRRLTGVYGRPILGTIVKPSIGLAMEDLQRMITDVSAAGLDFIKDDELNANPPYAPLELKVKSVMEAVERAADATGKKIMYAFNITGDIEEMKRNHDLVVKASGNCVMVSILSVGLAGLAHLNSYSEVPIHGHRNQWGMLTRCPMLGIEFAAYQKLCRLAGADHLHVNGLNSKFYESNESVVRSIEACTAPMYGGYAAMPVVSSAQWAGTAPATYAATKTVDVMHLAGGGILAHPAGPAAGFESMKLGWEAAVKGIPLEEYAELHPSLKQAIAKYGNGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL81</accession>
    <name>A0A398CL81_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_12210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03423">
        <property type="protein sequence ID" value="RIE03423"/>
        <property type="gene ID" value="D3H35_12210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="157" mass="18426" checksum="7920998BB3DBACF1" modified="2018-12-05" version="1">MTITEQIDKINRQLTQKGFKLTKQREATLMVLLENEKDHLSAEEVFMLVKGRYPDIGLATVYRTLELLSELHVVQKMNFGDGVARFDLREDHTHMHHHLICSECGSVKEIKEDWLLELEQRLEREFGFTVTDHRLDFTGYFNKCGNKECKRTRKAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLA2</accession>
    <name>A0A398CLA2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Copper amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_27050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00627">
        <property type="protein sequence ID" value="RIE00627"/>
        <property type="gene ID" value="D3H35_27050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017446836" evidence="3">
        <location>
            <begin position="28"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="113"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="167"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="246"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="4">
        <location>
            <begin position="424"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="529" mass="55154" checksum="9D4CD492027426CA" modified="2018-12-05" version="1">MSSRNKRNLLTVLGLTLSLSLPSVVSAAPADGWLKSASLFEIRTLAGQSEWGHANGAASASTFFHPRSLLELSDGRVVVSDSGNNMIRVVKAGQVSTLTGLYIGDDSAGLPLGSNKDGQSSEAGFNLPMGVAADGQGAIYVADSGNHSIRKIAKDGTVTTLAGNGNIGQTDGKGANAAFYSPSDVAVDAQGNVYVADTLNNVIRKISPDGTVSTVTATFTRPIEYFPGAVEYAGDFADGPIATARFNEPSGLAIDAKGNLYVSDRGNQRIRYIDFGTGKVTTVAGGGSYAAQAPYIEGDYVDGAAGTARFNAPEGIAIAQDGTLIVADSLNHAVRLIRNGQVTTLTGVATEFGQADGVPGSAQFNHPTDVAVLSDGRLAISDEYGNKLRVLQPYSKPANFAAGKTVQLLLDGKLLKPEVAPRLKDGSVLIPLRSLGESLGYTFTWDPKTSTAVMSKGSVSYSITKGSKNVTKTTVGTASTDNQKLVLNGTPITANDRFLVPVRFFATESGYDIQWDAQANAVIIRSKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLA3</accession>
    <name>A0A398CLA3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03040">
        <property type="protein sequence ID" value="RIE03040"/>
        <property type="gene ID" value="D3H35_20850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="79" mass="9160" checksum="343D9F77CC3082CA" modified="2018-12-05" version="1">MSLKKGLRLWRHLPSRVFRVLRSSNVTVMDKLLFIVPVALYWVLPDFMPFMPIDDAAFTALAAGWYARAMERKYGLGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLQ1</accession>
    <name>A0A398CLQ1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative N-acetylmannosamine-6-phosphate 2-epimerase</fullName>
            <ecNumber evidence="6">5.1.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ManNAc-6-P epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nanE</name>
        <name evidence="7" type="ORF">D3H35_17020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23932"/>
            <dbReference type="ChEBI" id="CHEBI:57599"/>
            <dbReference type="ChEBI" id="CHEBI:57666"/>
            <dbReference type="EC" id="5.1.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the NanE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.9" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03162">
        <property type="protein sequence ID" value="RIE03162"/>
        <property type="gene ID" value="D3H35_17020"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047465">
        <property type="term" value="F:N-acylglucosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009385">
        <property type="term" value="F:N-acylmannosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006051">
        <property type="term" value="P:N-acetylmannosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04729">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01235">
        <property type="entry name" value="ManNAc6P_epimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007260">
        <property type="entry name" value="NanE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36204">
        <property type="entry name" value="PTHR36204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04131">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="221" mass="24019" checksum="3E2102AEEAF2D99D" modified="2018-12-05" version="1">MFKQKGLIVSCQAFEGDPLYGDGVMAKMAKAAEQSGAVGIRACGADDILSIKETVNLPIIGLTKRNVPGSQIYITPELSDVMEILAAGAHIVALDMTDREDRLLQVVKWIDYIHTRNAWVMADISTYDEGRKAEQLGVDLISTTLSGYTPYSPQQVKPDIDLVQRLSESCAIPIVAEGRISNPHEAKEAMEAGADYVVVGSAITRPQLIVKQFVDQLITAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLR2</accession>
    <name>A0A398CLR2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_11900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03375">
        <property type="protein sequence ID" value="RIE03375"/>
        <property type="gene ID" value="D3H35_11900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="205" mass="24227" checksum="B1D97AA86FDBE477" modified="2018-12-05" version="1">MGVKETDVINSPVLDNIESVMKTFTRPWFIAGGWSIDLAVGEKTRNHKDMDICIFREDVEYALEHFQGWDVHVAVPGEHRLERVNELGDLNPPRYCLHLFKGDEFLEILLTERRKEEVIFRKNREINMHISDFIRGHLPRLYVNPAWQLLFKSLSTREEDEHDFRVYRGRVKDTKSKKWLLDSMIKVKGNAEWIEKLRNDFSEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLV5</accession>
    <name>A0A398CLV5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01848">
        <property type="protein sequence ID" value="RIE01848"/>
        <property type="gene ID" value="D3H35_13745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="104" mass="11567" checksum="3A8B71246FA8FF17" modified="2018-12-05" version="1">MQPFTERVVAIIKAIPAGYVMTYGQIAEEAGSRRGARQVVRILHSLSEKHGLPWHRVVNARGEIALGEGEAGYSQKLSLESEGVVFELGGRIDLNKYRYVELQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM13</accession>
    <name>A0A398CM13_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_07300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04386">
        <property type="protein sequence ID" value="RIE04386"/>
        <property type="gene ID" value="D3H35_07300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="6"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="398" mass="41397" checksum="CBF504A532334091" modified="2018-12-05" version="1">MPDSWKIYLLAVVSFLVGTSENIIAGILDMVAGDVGVSVAAAGQLITVFSIAYAFGTPILMAVTARMERRKLMLAALGVFFVGNLLAFAASGFIPLMGSRIVLALGTGVFVVVALMVTSKLAAPGKQGSAIATVVMGFSTSLIVGVPLGRVIAAAYDWKLIFAGIGALSLLAMLAIYRTIPRAEGEEPVPIRRQLELLKQPKIAIALSVTFFWIAGYSVAYTYISPFLLTITGLDERGVSIGLFAFGIASLIGSKVGGFGTDRWGIPRTLIGGMLVHALSLLLLSAFSHSAVIVFPLLMLWAFSAWSSGPTQQYNLMTIAPEASGIMLSLNASVLQLAMAAGAGVGGVIVNGVSLSAITWLGAAGVAVAATAAAKSFGLLPIRFRKLKKDVLEANAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CME0</accession>
    <name>A0A398CME0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000035">
        <property type="protein sequence ID" value="RIE03615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03615">
        <property type="protein sequence ID" value="RIE03615"/>
        <property type="gene ID" value="D3H35_10775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="96" mass="11047" checksum="F35FDF2C8AA1E741" modified="2018-12-05" version="1">MAVLDFQQPIRGNGYPIYYPFEGRGAHLLTPDKLSPAVRPGGLPDVQLQFYRGSNPMLPPQPYGLLDIRLEARYPFEEALVKLRELHPRARLNRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMF7</accession>
    <name>A0A398CMF7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_12395</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03452">
        <property type="protein sequence ID" value="RIE03452"/>
        <property type="gene ID" value="D3H35_12395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="19"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="416" mass="45334" checksum="D1E7ACD0355FEE55" modified="2018-12-05" version="1">MTSERPDTKSRLSRNYKLQLATVFVGFLVFGFSENIKGPAIPRIQTSFGIDEMQLGTLLSLNALGYLLACTFTAFLVRKLGIKRVSLFAFGSMTLSGILIFLSHHYSAFSVSYFLMYIGNGILEIALAILGARIFVRNTGTMMNLSHFFYGLSSTVAPMIASGLMTVTVLSWELDWRGMYLLILSLSVIPMIPALFASFPGDELAENERIPWSSLMRDRTVWLLVLILTFGVVSELAVGGWLVNYLEKAYGWESASASGMLSAFFLCFTFARLFLGPITDRIGFTLSLIIFSGFSGLCTIAAIAAGQAGAILFAAAGIGIAPVYPTIMAFIAKRYRRQSDTVITFTVTLMGIGNVIGNYLIGAITQSFKAGDTARADAGLMRGLQAGYSFIALCALLCSATGIILYRRLKKRNELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMH6</accession>
    <name>A0A398CMH6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4044 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04566">
        <property type="protein sequence ID" value="RIE04566"/>
        <property type="gene ID" value="D3H35_05615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="31" mass="3724" checksum="CDE853EB4BC0DB09" modified="2018-12-05" version="1">MNNRWFKIVVYVMLFALLTSTILMSVGWLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CML1</accession>
    <name>A0A398CML1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Non-homologous end joining protein Ku</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ku</name>
        <name evidence="5" type="ORF">D3H35_09840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer. Interacts with LigD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic Ku family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03843">
        <property type="protein sequence ID" value="RIE03843"/>
        <property type="gene ID" value="D3H35_09840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00789">
        <property type="entry name" value="KU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01875">
        <property type="entry name" value="Prokaryotic_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="Ku70/Ku80_beta-barrel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009187">
        <property type="entry name" value="Prok_Ku"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41251">
        <property type="entry name" value="PTHR41251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SSF100939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02772">
        <property type="entry name" value="Ku_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="4">
        <location>
            <begin position="52"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="276"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="359" mass="38639" checksum="4FD067866AE19432" modified="2018-12-05" version="1">MHTVWKGAISFGLVHVPVKMFTATEDKDVHLRYIHKECGTPIANVRTCPHCDKQVEWEEISRGYEYEKGRFVLFDSEELDAIKPDTTRTIQILDFVDLTEIDPLYYQKAYYLSPDQAGSGAYSLLLEAMRQSGKIGIAKVAIRSKSSLAAIRAVDNCICMETMHFPDEIRALAQVPNLPEKTAAINERELTMAKMLIEQLSTPFEPEKYTDDYRSALLEAIQRKVSGEGADVVTAPAAERTNVIDLMAALQASLEAVKPGGGAAAGMGGQALTGKSAASKAGARKATGGKSKAGASEDDPVAVENATSDKTSKVSPSTNRPARSSKSKVSAADSVADTPTGDKPATRGTRSRSKKEIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMQ2</accession>
    <name>A0A398CMQ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysM peptidoglycan-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_07900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03883">
        <property type="protein sequence ID" value="RIE03883"/>
        <property type="gene ID" value="D3H35_07900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="263"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="307" mass="33534" checksum="7088297467BD1A86" modified="2018-12-05" version="1">MEEPYYSDYAQSVQGTTERPPYEPAPAQQDNVWGTGGQQAFTPAWPGYELEEQGAPVGRDDGGGGGEAYSSATLSSAEQQTQPDNGWLSFFQNGNPSFGHKAVQYEEEVGREPEQEAAVQASDGFLGQDELSRIVYSDGSSSANLWGDVSDRRDELDAAEESSKFPSESPSEAPKDDKADLKVAVGGRPLDAPVKPTASVTVLSLLGEKGAIREAEQKLLAAKLAEEEAALLKEAKESTGDEVEWTQLFLAKDSEHQSFRKVKLCIVQRQDTLEAIATRYNVQTRELQLHNRLTDPYISEGQVLYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMV0</accession>
    <name>A0A398CMV0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Histidinol-phosphatase</fullName>
            <shortName evidence="7">HolPase</shortName>
            <ecNumber evidence="4 7">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_25410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="4 7"/>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00911">
        <property type="protein sequence ID" value="RIE00911"/>
        <property type="gene ID" value="D3H35_25410"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="PTHR21039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="8">
        <location>
            <begin position="4"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE00911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="266" mass="30172" checksum="96F99AFBA6D5004F" modified="2018-12-05" version="1">MKFDYHTHHERCGHASGSVRDYIEAALNNGLHIIGISDHTPAFALEEDRPWPGGAMAKSEFPIYVNEVLQLKQDYAGRIEVLLGIEADFLPDSLDVYRSVIHSYPFDYVIGSVHDFAGIGLYNADHWTNLTSQGKLELKNLYYQYIAQSAKCGLYDILGHVDALNRYFPEYSDLRTEAADVTLKTIAASDVVIEINSSDNNWVPNEAFLERALYHGVKVTFGSDAHEPEQTGHDFEKVQSSLRDIGYREWATFRGRKRTMVELHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMX9</accession>
    <name>A0A398CMX9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_29650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00274">
        <property type="protein sequence ID" value="RIE00274"/>
        <property type="gene ID" value="D3H35_29650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017480016" evidence="2">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="78" mass="7649" checksum="852D5536BB53DF78" modified="2018-12-05" version="1">MVAFALLLTVPAVMTGCSTATSRSNCNPNYENCDDNGYSGGGGGYVYSGGSASKKNSSSSDSGIYKGFGSGGKSSVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMZ7</accession>
    <name>A0A398CMZ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000035">
        <property type="protein sequence ID" value="RIE03610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03610">
        <property type="protein sequence ID" value="RIE03610"/>
        <property type="gene ID" value="D3H35_10750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="240" mass="26874" checksum="AD9DF05D366F34BC" modified="2018-12-05" version="1">MFKFIKYRFPIDRPDGKKGGGFLIADVEFSVPEDKLAKVKEALQERLDEQARNLGQQTPASPVKFGQLSFLRGTASITVLDDGGSLVEKVINPAAPSLYGKMITPFTRIVRRRRNAAGAGSPGKRRHRSGRLRLWMPVRLPPVKARIWFKAEKFMEFHQEIDVEENFWSEDDYREKISEKFSQREAGGVQIDPGGVVDQKVIGAVRIGPCGIGGQARQNGSRRHSAGRSGREQMVHGARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN67</accession>
    <name>A0A398CN67_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03742">
        <property type="protein sequence ID" value="RIE03742"/>
        <property type="gene ID" value="D3H35_09295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="159" mass="18193" checksum="69F82B4304119657" modified="2018-12-05" version="1">MSNPFKYTGEIQDDESGLIYLRVSIMILLLVDLLMRKRMRGIDDPLTLNLYTYVGDNPFIYTDPSGHKWKLARDVWNFVSGSASKSYQYVKDQHTSWEKGLSYWTLGMSDPFFASAKNSIVLTNNPNGATGFYAKAVEFLVNQGYKFIKNGDYWSAVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNK3</accession>
    <name>A0A398CNK3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homoserine O-acetyltransferase</fullName>
            <shortName evidence="6">HAT</shortName>
            <ecNumber evidence="6">2.3.1.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Homoserine transacetylase</fullName>
            <shortName evidence="6">HTA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">metAA</name>
        <name evidence="8" type="ORF">D3H35_09020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13701"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="EC" id="2.3.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MetA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.31" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04075">
        <property type="protein sequence ID" value="RIE04075"/>
        <property type="gene ID" value="D3H35_09020"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008899">
        <property type="term" value="F:homoserine O-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019281">
        <property type="term" value="P:L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03131">
        <property type="entry name" value="GATase1_HTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00295">
        <property type="entry name" value="MetA_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005697">
        <property type="entry name" value="HST_MetA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033752">
        <property type="entry name" value="MetA_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20919">
        <property type="entry name" value="PTHR20919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04204">
        <property type="entry name" value="HTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000450">
        <property type="entry name" value="H_ser_succinyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01001">
        <property type="entry name" value="metA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6 7">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for acyl-CoA specificity" evidence="6">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="6">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000450-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="313" mass="35668" checksum="28A40B87373E66DE" modified="2018-12-05" version="1">MPIKVPDNLPAKEVLAGENIFVMDESVAYHQDIRPLRIAILNLMPTKETTETQLLRLIGNTPLQLEAVLLHPKTHTSKNTSAEHLESFYKTFEDIKDQRYDGMIITGAPVEHLPFEEVNYWDELKEIMDWSVQNVTSTLHICWGAQAGLYHHFGVQKYPLPDKMFGVFPHAVTKPNTKLLSGFDEMFYVPQSRHTEVRREDIEKAPGIDVLSESEEAGVYIAASHDGKQIFVTGHSEYDPLTLKWEFDRDQAKGLRVNVPKNYFPQDDPAKLPVSTWRAHANLLFSNWLNYYVYQATPFELGAAEKQTSPIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNM7</accession>
    <name>A0A398CNM7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03932">
        <property type="protein sequence ID" value="RIE03932"/>
        <property type="gene ID" value="D3H35_08180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="40" mass="4407" checksum="2666EFD4459CD40D" modified="2018-12-05" version="1">MTSVTDSTGTTTYGYDVLNRLTSVLRPNGDNDANTYELHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNM8</accession>
    <name>A0A398CNM8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Siderophore biosynthesis protein SbnG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_22535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01181">
        <property type="protein sequence ID" value="RIE01181"/>
        <property type="gene ID" value="D3H35_22535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="3">
        <location>
            <begin position="17"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="259" mass="28953" checksum="43DD461638688A8D" modified="2018-12-05" version="1">MRKNKLKEKIRGGEPVFGLFVSIPHPIVIELIGYAEFDFVIIDCEHASTNMETIEEMIRAAELMDITPLVRISKVDRNEILKVLDSGAQGIVIPHVESKEQVEEAVRCAYYHPIGMRSLNSGRPGAFAKYSLTDYIAEANEELMIVPMIESVEGVSWSESILSVPHIDFVLEGAADLSQSLGVPWDTEHPKVQEALETLHEASERCGVPYAVVSRNLDSHVKWAKKGTNIFVLGDDRNTAFRAYSQKREVYRGVLGGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNN8</accession>
    <name>A0A398CNN8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02869">
        <property type="protein sequence ID" value="RIE02869"/>
        <property type="gene ID" value="D3H35_19800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="521" mass="57893" checksum="31BD7FEE9CEA3A8F" modified="2018-12-05" version="1">MSDSRPKLLLFSHLCSPVNVTGAEKVLLLFVRELMRRFHCVLVVPQEGALSEQARGIGIRVIVMDLPRCPSIYDAPPSTREEADSLVRHPSWAGLLSMMAWENPSYIWVNTCVHLMPAMAAKCLGIPVVWNIHETITDTPNRQTSADLITAHADIIAGVSDTVLSPLKGSGSPSMIWFPPFLYREELLPAGWAIKRARFRTNLGWSEEHRVAGVMAAHFQPFKGLEPFVSSMLKVAESIPHARFLIAGNPIDQAHYEACRQAVAHSGMSDRFAWLGYVENVHEIIPAVDAIVVPSLVAEGFGMTALEGMFFEKPVVAFASGGLTELMSTTGNAELLVPVGDTEALAERVRTLFADEGRLRLIGLRCSEEAERQFGADAFRARVDSLIAMLPPARPFPPSFLIRGSGPTIYLLENGKKCPFQSVHDFRSSGYSFNQVVVVNDDLLNRIEMGSPIGVVARRPRRQGRAKPRRRLCRSRPGRRCRRAATGKSRRRSSVRSRRGRGQGRRKSIVRRRSKSRKKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNQ0</accession>
    <name>A0A398CNQ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inositol phosphorylceramide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_27710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00534">
        <property type="protein sequence ID" value="RIE00534"/>
        <property type="gene ID" value="D3H35_27710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="6">
        <location>
            <begin position="88"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="285" mass="32472" checksum="1E7D735F339189E7" modified="2018-12-05" version="1">MILFQSMSSVTMWSALTVTILIWYGTSRQPFGTAYLLLRSLATSRKYLLFFVSMSAILMLNKNELKLERHFDVSYDLTKTLTGWEGSWHAGFQSFLHSDWLTAVCVFFYVVVFQSVMIASIGVYTADRNLKMYYSFCIALLLNYCIAVPFYLFVPVNEVWFAEPQVRFLMLDSFPTFEHAYRSLSGLDNCFPSLHTSISVTMALIASRSGNRRWMIFAWINAGIIILSIFYLGIHWMTDMLAGCALSVFAATIGLKIGAWADRTSPDPLLRRKKSKMQTSRSLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNU6</accession>
    <name>A0A398CNU6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_08640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04012">
        <property type="protein sequence ID" value="RIE04012"/>
        <property type="gene ID" value="D3H35_08640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="250" mass="27594" checksum="34DA3D7EF02EF462" modified="2018-12-05" version="1">MIKLKQITKSFGKNQVLKGIDLVVEKGEVVAILGPSGSGKTTLLRCINYLEKPSDGEITIADLTVQCKRPSKKEVHALRGKTAMVFQQYNLFRHKTALENVMEGLVVVQKVPKEEARKRSVELLEKVGLAGKLDAYPSQLSGGQQQRVGIARALALNPEVILFDEPTSALDPELVGEVLGVIRKIAKEGITMIIVTHEMGFAQDVANHVVFMDEGVVVEEGKPNEIFVSPKEERTKQFLKRFTPEGTYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP78</accession>
    <name>A0A398CP78_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage III sporulation protein AE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spoIIIAE</name>
        <name evidence="3" type="ORF">D3H35_26425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00734">
        <property type="protein sequence ID" value="RIE00734"/>
        <property type="gene ID" value="D3H35_26425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014194">
        <property type="entry name" value="Spore_III_AE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09546">
        <property type="entry name" value="Spore_III_AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02829">
        <property type="entry name" value="spore_III_AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017267182" evidence="2">
        <location>
            <begin position="35"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="408" mass="43423" checksum="D0001AFF9453B587" modified="2018-12-05" version="1">MRRAGGWRKWLAVLPLAALLLTAIGWVRGEAAAAAPDAPAASSDLSGDLAKEQSKDVDVGEIESYWNDLKNRYGGYFPEGKLPELKELMFPEGKSFGFGQALGGLFRFLLHEVLYSGKLLVTIVLLTVFTMILETMQNAFERNAVSKVAYAIAYLVLLILAVNSFRTATAYAGDAISSMVQFMLAMVPLLLTLMAASGGVTSVAVLHPLIVFMIHTIGTFIHLIVFPLLFFSAVLHLVSSVSERFKVTQLANLLRNVGVGLLGVLLTVFLGVLSVQGATGAVTDGIALRTAKFVTGNFVPVVGRMFSDAADTVMSASLLVKNAVGIAGVVMLLFLCAFPAIKILALALIFNISGAVMQPLGDSPIVQCLQTIGKTLIYVFAALASVGLMFFLAVTIILTAGNATLMIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPF4</accession>
    <name>A0A398CPF4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_26890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00814">
        <property type="protein sequence ID" value="RIE00814"/>
        <property type="gene ID" value="D3H35_26890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="8"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="93" mass="10892" checksum="0BF089A2EA3C4FAF" modified="2018-12-05" version="1">MKAQQNQEQIEQVEQMLIERLSELLEDPMFREKITSEANLIDAGMNSIMMVRLIVDIEQHFEVVFEDEEMLEENFITLHQIASNILRKLGQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPK6</accession>
    <name>A0A398CPK6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmF</name>
        <name evidence="5" type="ORF">D3H35_07680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04455">
        <property type="protein sequence ID" value="RIE04455"/>
        <property type="gene ID" value="D3H35_07680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044957">
        <property type="entry name" value="Ribosomal_L32p_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35534">
        <property type="entry name" value="PTHR35534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="57" mass="6535" checksum="E238B49F677E427A" modified="2018-12-05" version="1">MAVPFGKTSKSRKNKRRTHFKLVVPGMVKCEQCGELKLSHRVCKVCGTYKAREIIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPS6</accession>
    <name>A0A398CPS6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04432">
        <property type="protein sequence ID" value="RIE04432"/>
        <property type="gene ID" value="D3H35_07560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="121" mass="13118" checksum="6316CA45F331D533" modified="2018-12-05" version="1">MSFTCPKLSSNSAEGSPGSGSFVSAGLQAYSESGHPLNLTYSVGTTNAACWSSGSSNDGEIKCSQTEFEDAKLTIRIKNENNYQLKFCGYWNDNSNGASNWYWAPGPRDVPPPAAKERFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPX0</accession>
    <name>A0A398CPX0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_24415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01501">
        <property type="protein sequence ID" value="RIE01501"/>
        <property type="gene ID" value="D3H35_24415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039532">
        <property type="entry name" value="TetR_C_Firmicutes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14278">
        <property type="entry name" value="TetR_C_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="202" mass="23381" checksum="4E76161454A73FBF" modified="2018-12-05" version="1">MAEQIDRRQVRTKQLLRHALMELIEEHGTESLTVTNISNRAGVNRGTFYLHYRDAGDMLEQIKEEVFGDLIRLLKQIDVFELMEYASKDAVYPRAQRAMEEIYRNRDFFKVIFGPKGDPSFPLRIKSVMKEHFSKMFDTRQPAKEKMLVPLDYLVAYTTSANLGVIQYWIENGAQQSPEEVALILTRLVNHGPLTSTGLRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ58</accession>
    <name>A0A398CQ58_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D3H35_19980</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02898">
        <property type="protein sequence ID" value="RIE02898"/>
        <property type="gene ID" value="D3H35_19980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031967">
        <property type="entry name" value="PhoR_single_Cache-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16736">
        <property type="entry name" value="sCache_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017279803" description="Histidine kinase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="192"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="12">
        <location>
            <begin position="249"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="373"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE02898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="600" mass="67125" checksum="61B8C1B31C57636C" modified="2018-12-05" version="1">MTKFRLKLTALFMLLIGLSVLAAGLFTGQYYKKNHQDALREHMIRETQVLNAMAPWPETTEVEGQVAFLQQQAQRFKDIAGMRVTYIRPDGVVVGDSDHDPVTMENHKNREEIREALESGEGSSIRRSETLRQNMLYVAQSFKSGDRVVGVIRLSMSLSDVERSLNNMWLALVFGLALLFALAAIVSYRVALGVTRPLEKMTAAAKRMANMDYAIRIPEGGRDELGELARTLNAMGANLQEQLDQIGRNGSRLQSVLDNMTSGVVMIAHDGRITLYNREAEQLLGNTGKERVGRSFTEFKQHYELVQLIRTGLEHGDKLYDELTVYYPEERMLQISLVPMTMSDDEEPGLLLVMQDVTAIRRLENMRSEFVANVSHELKTPVAAVKGFAETLLAGAMNDGETARSFLTIIQDESDRLNRLIGDILELSKIESRRSPLQFSPIDMDSFLERMKELLAAEAAKKNISLDISSEAGLFIEADEDRLGQMLMNLIQNGINYTTDGGKVKVIAEAFTTDEGDDEPMDWVRITVSDTGIGIPKKDMPRIFERFYRVDKARSRSSGGTGLGLSIVKHLVELHRGSIRVESTVGVGSQFILELPMLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQH1</accession>
    <name>A0A398CQH1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 14">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">lpdA</name>
        <name evidence="17" type="ORF">D3H35_04805</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="12 14">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 14"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04795">
        <property type="protein sequence ID" value="RIE04795"/>
        <property type="gene ID" value="D3H35_04805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12 14" id="KW-0274">FAD</keyword>
    <keyword evidence="5 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 12 14" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10 14" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="16">
        <location>
            <begin position="11"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="15">
        <location>
            <begin position="349"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="147"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="183"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="47"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RIE04795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="473" mass="50009" checksum="1EA8881A6639C3CC" modified="2018-12-05" version="1">MVVGDASLDIDLLVIGAGPGGYVAAIRAAQLGQKVIIADKAKWGGVCLNVGCIPSKALINAAHHFESMQHASDYGLSADNVSVDFAKVQEYKGSVVNKMTSGVEMLLKANKVQLFSGEVMFINEHEARLFNDQEAPRYRFKNCIIATGSRPIELKPFPFGGRILSSTEALSLPEVPKSLVVIGGGYIGIELGQMYSKFGTQVTVLEGADTILPGFDKDMSNLVVKKLKKANVEIVNGALAKSAEQTDKDVTVTYEVNGETKTVTADYLLVTVGRRPNTDGELGLDLIGVKVTDRGLIEVDDQCRTSIPHIYAIGDIVPGAALAHKASYEAKVAAEAIAGLPSKVDYKCIPAVAFSDPECASVGYTEKEAKEKGLTVKSSKFPFGGNGRAVTLNGADGFMKIIHEVESGLVVGAQIAGVEASNMIAEIGLAIEMGATIEDIALTIHAHPTLAEITMDTAELAMGHPIHTIAPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQH8</accession>
    <name>A0A398CQH8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_04715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04783">
        <property type="protein sequence ID" value="RIE04783"/>
        <property type="gene ID" value="D3H35_04715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="549" mass="60458" checksum="00846EE3CC24B278" modified="2018-12-05" version="1">MSGKTLLVEPGAIFANRYRVVEPIGQGGMGRVYMAEDLRLEGRLRALKLIATLPEEREAFIREARMLCRLTHPNIPEIVDYYSPNEDGVAAIVMDYIAGDTLAQRFDKFGRKLSFGQVLQMTIQLCEVLQYLHGQAPAIVYRDLKPSNVIIDSRDRAVLVDFGIARWHRPNAVSDTLQLGTPGFASPEQLLGKQSDERSDLYGLGALVYFLLTGGFFAIRRNRHSEKFVVEAVPRAFREMVELLLSEDPSHRPKSAASVLEHLLNIRELGASGEGSFRFDASKGGGNSFIKRDVTIAAVLSAYPGAGATFVTLALSSALSIAGVDHAVVECPGGEAEMYGLLDGARKMPARAQFANGACQRVAGPIWREGRASYVPLDPFRAAQAQCHCVLDESFVSFLQKLGAPLVLLDVSSRWEHPDAKEWIGNIADSIIWVADCYPSKWSLKRQQEGASLYQAIEGRQAAAIWIANRDHSFAERKEWLSMFPVAPLTALPRFSEDAVLKAIWDGAGVPSAKKDKELYFRSLKTVLKRIVPAGVAKDVLTANTAYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQM2</accession>
    <name>A0A398CQM2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_15270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02117">
        <property type="protein sequence ID" value="RIE02117"/>
        <property type="gene ID" value="D3H35_15270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="301"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="473" mass="50657" checksum="4F830D7F0BF6277E" modified="2018-12-05" version="1">MDPLLDVLKEAGEAVIRLFALPYIYIAIAMVWWHARQGVILQRRLFHVRLYGSLSLTLSRLGAGVAVGLVLSAASFGVGAKLNSDTILCIWLAMFVLAVFRLRYICLAYAAGAIGVAQAIARKTLPDGYDGLFARSFEALGGVDIASLLFLAGLLHIAEGLLVRFQSSKMAIPLFMEGKRGKPVGAYALSGVWPIPLLWLIPSASSAEGFTLPWAPLLGDGAASWALLAFPVLIGFSDRTETFWPEQKARASGNALILYGALVAALAAGAQWWTPLGVIAAVAAFLLHEGLVLWSRWREKGRNPIFAQDGSGVKVLAVLPGTPAAEMGLVAGETIKKLNGSIVRTKEQLHAALQLQSAFCKMEVVNRDGHVKFVQRARYAGEHYQLGLVLAPDEDVDFVAAPRSASIWQGLRNAGARPRNGASWQAAQAELAAARELDAAKEAEREAAEAAAAALAEPEVDPGLPPRKERKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQM4</accession>
    <name>A0A398CQM4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Esterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04792">
        <property type="protein sequence ID" value="RIE04792"/>
        <property type="gene ID" value="D3H35_04785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="248" mass="28239" checksum="9581D38E00274B15" modified="2018-12-05" version="1">MSDSPVVRRTIIKFEVPSRLLPEGKRDIRVYLPPGYQEVLSYPVVYCQDGEDFFNFGRIATHAQRLILDEDWEPFIVVGVDVDKKLRTSEYAPDGQRHFLYTRFFTEELLPFVEAQVAVRRTVEDRLLAGDSLGGTVSLSIALQRPDLFTRILSLSGAFYASSQAQATEKTDLSWLSIWMVVGLQETAYETDTGIYNFVELNRKMSALLEQKGATISYSEKPGEHKWGFWQNEIPGGLREFVGPDGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQR6</accession>
    <name>A0A398CQR6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease III</fullName>
            <ecNumber evidence="10">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">nth</name>
        <name evidence="13" type="ORF">D3H35_04285</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="10"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04895">
        <property type="protein sequence ID" value="RIE04895"/>
        <property type="gene ID" value="D3H35_04285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10576">
        <property type="entry name" value="EndIII_4Fe-2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="12">
        <location>
            <begin position="38"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="211"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE04895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="247" mass="27847" checksum="9F113FE8BB45BDA0" modified="2018-12-05" version="1">MNAKTMRHTLDIIAEMFPDAHCELNHRNPFELTIAVLLSAQCTDVLVNKVTADLFEKYRSPEDYLRVPLEELENDIRRIGLFRNKAANIQKLCRILIEKYDGEVPREHEALTGLPGVGRKTANVVVSNAFGVPAIAVDTHVERVSKRLGAAKPDDSVLEVEKKLMKLVPREEWTLTHHRLIFFGRYHCKAQNPQCEVCPLMEHCKEGKARMKAALRAPTQPKSRSSSATKKAAVNADNKKNKRSVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQS5</accession>
    <name>A0A398CQS5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylglyoxal synthase</fullName>
            <shortName evidence="1">MGS</shortName>
            <ecNumber evidence="1">4.2.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">mgsA</name>
        <name evidence="4" type="ORF">D3H35_04090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dihydroxyacetone phosphate = methylglyoxal + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17937"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="EC" id="4.2.3.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylglyoxal synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.3" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04893">
        <property type="protein sequence ID" value="RIE04893"/>
        <property type="gene ID" value="D3H35_04090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008929">
        <property type="term" value="F:methylglyoxal synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019242">
        <property type="term" value="P:methylglyoxal biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01422">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00549">
        <property type="entry name" value="Methylglyoxal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004363">
        <property type="entry name" value="Methylgl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018148">
        <property type="entry name" value="Methylglyoxal_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30492">
        <property type="entry name" value="PTHR30492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006614">
        <property type="entry name" value="Methylglyox_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00160">
        <property type="entry name" value="MGSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01335">
        <property type="entry name" value="METHYLGLYOXAL_SYNTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MGS-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="34"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="54"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1 2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006614-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="139" mass="15489" checksum="49877AEA79929711" modified="2018-12-05" version="1">MHIALIAHDRKKDEMVNFVIAYENVLAPHKLYATGTTGSRIMESTSLNVHRFMSGPLGGDQQIGALVAQNEMDLIIFLRDPLMAQPHEPDIIALLRLCDVQGIPVATNIATGELLLKAMERGDFAWRELVHKYKPGIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQW6</accession>
    <name>A0A398CQW6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_18710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. EmrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03188">
        <property type="protein sequence ID" value="RIE03188"/>
        <property type="gene ID" value="D3H35_18710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="14"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="517" mass="54882" checksum="10E842BB0613430D" modified="2018-12-05" version="1">MRSESTSKSSIGIVVAGLLLGILMASMDNTIVATAMGNIVGELGGMDKFVWVTSAYMVAEMAGMPIFGKLSDMYGRKRFFVFGIIMFMIGSALCGTAHSITELAIYRAIQGIGGGALVPIAFTIMFDAVPPENRGKLGGLFGAVFGMSSIFGPLLGAYITDHIAWEWIFYINLPLGVIAFIMIAFFYKESHEHSKQQIDWWGALSLIGAVVCLMFALELGGKDNFAWDSWKIISLFAGFAVLAISFLIAETKAAEPIISFSLFKQRLYATSILAALFSGAAFIVASVYIPIFIQGVLGGTATNSGLVLLPMMLGTVVTATLGGFLLTKLPYRNIMVPTFAILVAGTALVATLTSDSTRLLVTLYMVLIGLGIGASFSVLSNAAIHGLAARQRGSASATLNFLRSLGMTLGITVFGIIQSHSFLNKLAGEFGGGEGGGQLAMPEGLDFQDPHSLLDPLTRAQIPQDALDKITDILSSSIVNTFAWAIIPAVLALVVSLFMGRSKLDPAAEQEAYNASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQY9</accession>
    <name>A0A398CQY9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_03420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000020">
        <property type="protein sequence ID" value="RIE04932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04932">
        <property type="protein sequence ID" value="RIE04932"/>
        <property type="gene ID" value="D3H35_03420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901575">
        <property type="term" value="P:organic substance catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid" evidence="4">
        <location>
            <begin position="38"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="5">
        <location>
            <begin position="146"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="6">
        <location>
            <begin position="495"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="675" mass="74227" checksum="D9300EA2E2F38987" modified="2018-12-05" version="1">MAWIPAVAIELPFANLVAQENVPTRVTELVKPIAAIATPEGDAVLDMGQNMVGRIRFSVTAPAGTEIKLTHAEVLDKDGNFYRGNIRTAKQTVVYIAKGEGTETYAPHFTFQGFRYVKVEGFPEQPGELPLDAFVGEVLHSDMEPTGAFECSDEMVNRLQRNIVWGQRGNFLDVPTDCPQRDERLGWTGDAQVFAGTALFNYNGGAFFTKWLRDLQADQLPDGGVPFVVPNIIQGYSSAAWGDAATVIPWAVYASLGDKRLLAEQYGSMKGWVDYIRSQGEREHIWNTGFHFGDWLALDAKEGSYMGATPNHMVTAAYFALSSRIVRDTAGVLGYADDEAYYGELAERVAAAFRDEFITPNGRVAAQTQTAHILALVFDLVDTKDRARIAKDLNELIVDNDYHLTTGFVGTPYLCFALSDNGYHETAVKLLLQKTYPSWLYSVSKGATTIWEHWDGIKPDGSFWSDDMNSFNHYAYGAVGEWMYRRIAGLSPDGAKPGYKRIRIEPDFTGGRLSYARAAYESMYGKVEAGWGFKDGQAEVYATVPANASATILLRGAVIDGVAVDGIDLAGAQGILSYRQQPEGVLIEVGSGHYVFAFARPKSSYRTYSADMRLGELVQWDAAKRVLDRHAPGFSEQLGHLRNMPLGMAANGPMGSALSKEQYEAIAGELSSLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR10</accession>
    <name>A0A398CR10_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 11">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rplV</name>
        <name evidence="12" type="ORF">D3H35_02265</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8 11">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE04995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04995">
        <property type="protein sequence ID" value="RIE04995"/>
        <property type="gene ID" value="D3H35_02265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE04995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="112" mass="12552" checksum="C00095D4A8D50FBF" modified="2018-12-05" version="1">MSQQAKVHVNNIRIPARKVRLVVDLIRGKKVGEAIAILRHTPRSASPVLEKLLNSAVANADHNYQLDVNKLVITEAFVNEGPTMKRFQPRSQGRAFSIFKRSSHITLVVSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRB7</accession>
    <name>A0A398CRB7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytanoyl-CoA dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_02955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05105">
        <property type="protein sequence ID" value="RIE05105"/>
        <property type="gene ID" value="D3H35_02955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="269" mass="30127" checksum="0096CF4152C969E2" modified="2018-12-05" version="1">MRADTKVQTPITQSHIDFYKENGFVQVDNMLTPKELTELRVYLEEAMQSEGDLSLKRDQSGGSYYKVLNQKINLWRDHAGMSAYSFHPRFAQSAMELSGVSGIRFFHDHGLWKMPGDSKATPWHQDTPYWPIQEADAGMMSIWITLDDVNEQNGCMAFVPKSHKLGKLTGIDFLNPQNIFDYVEGGQAEEQKPVIVPLKAGSCTFHNGLTFHYAHANSTDKPRRVLAIIFMPDGITYNGKEHPVTDGNGLKAGEPIAGPRFPLLAKADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRH3</accession>
    <name>A0A398CRH3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_09985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03869">
        <property type="protein sequence ID" value="RIE03869"/>
        <property type="gene ID" value="D3H35_09985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="Peripla_BP_3" evidence="2">
        <location>
            <begin position="28"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="118" mass="12962" checksum="E61EB6E24E937A8D" modified="2018-12-05" version="1">MKTCLQAAALRSTARLSRWQRGCRVRGAGGAELLKRKERPTAVFAANDTLAIGSSMRRTDWAERAEDLSVIGIDGTPLGLYIYPKLTSVSHPRFQIGKSRSSLLSIKSTETPRISTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRR3</accession>
    <name>A0A398CRR3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05252">
        <property type="protein sequence ID" value="RIE05252"/>
        <property type="gene ID" value="D3H35_01650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="99" mass="10846" checksum="350FD80204579A7F" modified="2018-12-05" version="1">MRVESGTIGNPGLEEKIRALTEEGGMPYEQAVMLAALARLNICSEEGKTLLQGLSKGRLRLPDEPASRWLAEIASWLYGPAGPKVQVTKRRKSMHADNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRV9</accession>
    <name>A0A398CRV9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02527">
        <property type="protein sequence ID" value="RIE02527"/>
        <property type="gene ID" value="D3H35_17710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="185" mass="20363" checksum="2185F67A64D2D178" modified="2018-12-05" version="1">MDLMSEFNGKKIGMMIGSMGFRMPTFMGENSDKLGVAPIPHFEGGNRTNPVFFDGYGISAKSKHPDAAWKFIEYLSLSGNEDSSKLADMYLATSKAVSEAIGQAKDPAKSVYLEELNYAVKPSIDNNPLFRQAWSEVLAAQFLNLLTVSDEDIPQKMKELALELDQQLIRLKNEQETAGSTAEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS67</accession>
    <name>A0A398CS67_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_10945</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03588">
        <property type="protein sequence ID" value="RIE03588"/>
        <property type="gene ID" value="D3H35_10945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="13"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="339"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="438" mass="46352" checksum="5A67CE1A29ADA070" modified="2018-12-05" version="1">MAWRNLANRKVQTIITILVVVIGVAVTLSIMMLSGGIKQGIVRASEPYGMIVGSKGSANQLVFNTIFLMDNPLANIDQAFYEKLSKDERVSLAVPFALGDNYRGFRVVGTDVSFFGLKGRPVDPPYFRLSSGRLFERSFEAIIGSDVARQTGLKLGDRFAGAHGVAAAAEPEEHAEHPYTVVGVLDAVSAPSDQGIYVSIDSYWIAHEHEEETADGATASAGAKNGSGSADADDKGSEAAHSENGEISGEHPVGGSDEENRGVTAALIKPKSYVGLLKLYQEINAGKDAQAVLPGQVLAKLFDMMGGGERVLRDVGYVVLGMAALTVALALYGSTVERRRTVAILRAIGAGRLSVMTIVLLESALVMVIGCALGTAAGYGLTELLTRYIGTQVSIAIPTAFEWEWLSFIGGVALLGIAAGLFPAFSAYRTETARYLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS97</accession>
    <name>A0A398CS97_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000034">
        <property type="protein sequence ID" value="RIE03618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03618">
        <property type="protein sequence ID" value="RIE03618"/>
        <property type="gene ID" value="D3H35_10610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="139" mass="15529" checksum="91476A3763FF3041" modified="2018-12-05" version="1" fragment="single">MFVQRSSVERFLKSQYEAGKLAREVVLTTEREDPITEMKYTVRYDIQFASPVLSFIAGRSGFATLTMPINEGSFARIIMADVEKRTIPIPGGRYSVQAIVPLAAIKGDTGEVIEHDNVVTFSDGNPHDNHIIVHFNSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSR3</accession>
    <name>A0A398CSR3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-antigen ligase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_09600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03798">
        <property type="protein sequence ID" value="RIE03798"/>
        <property type="gene ID" value="D3H35_09600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="295"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="469"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="506" mass="55895" checksum="B464151EEC0E6C26" modified="2018-12-05" version="1">MGKKPRLVRHAAAIFERRARHKECRFLRGKGGIGMIEAAIRLFKLRGWPFWFQNIALLLAGIPAAIWVGEYTSRNPGLLLQLAIVILLLIPAFILASTQSTYLIPYILLIWLVGAEIRRLADWSLGQFSSINLLSVSPLIVSGMLVFALAKQRIVMEPKAIELLKAYFIPFAYAAVIGVLLNKAAGIYSTANYFIPVLVFIYLAVNPPTEEQKEKWIRIYVTMAVVLSIYGWYQYVTLPPWDRFWMTSVNMVSLGTPEEFGFRIFSTLNSTGPLAVFLVSALIPAIVNKKWRGPFGLIGIPIMVSALALTLVRASWITLIAGVVAYFMFGSNANRWRMLAAVAILTVIGFIAFPLLPGGAEVTDRVSTLGSLESDQSANSRWGLLLYAIPEVLSHPFGTGFGSIGRSTALNGGEAFAGLGSIDNGYLGVFAAFGIFGGILYFRATWMQWSYTLNVDKRNPYRTLGIVNMVQLAVGFLFGGALFSLNAIIFWLFSGLIFTKTQNKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSW1</accession>
    <name>A0A398CSW1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05250">
        <property type="protein sequence ID" value="RIE05250"/>
        <property type="gene ID" value="D3H35_01640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="267" mass="28734" checksum="A0BF98842185D5E1" modified="2018-12-05" version="1">MDRAKREVVVRGLTLIALQNLTCLALWIGYPAFRIYAALVLAAGLLELVYHYRSVRPGRYANVLIVVAVLTSAVLFLEAERFAVYVLPIGLALAVYAFWGPAHQVRSPTFGALFAVGVIALGAGCLSLMAENGIAPVVTFLLLLQLNDAFGLLAGKRFGRTKLFPRISPNKTLEGYIGGALGVLAGILLLNGWIHTLSGTSVGKQLLIVCFILVFGNFGDLLFSALKRKLGIKDFGNLLPGHGGILDRYDNILFGAPLFALLWGLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT97</accession>
    <name>A0A398CT97_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAD-IIIA family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_08500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03988">
        <property type="protein sequence ID" value="RIE03988"/>
        <property type="gene ID" value="D3H35_08500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006543">
        <property type="entry name" value="Histidinol-phos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01656">
        <property type="entry name" value="Histidinol-ppas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="445" mass="49313" checksum="1BAD408D98343D0B" modified="2018-12-05" version="1">MKAVIMAGGKGTRLSEFTKEIPKPLIPIGGKPVLEHQIRLFVRYGIRDILIVTGHLGERIEQYFEDGASFGAKIEYFREERPLGTAGALAFLKERLTDSFLLVYGDVLFDMDLERFAAFHRSQGTVGTLTVHPNNHPYDSDVLKVNAAGRVERIFRKNEKRDFDYSNCVNAGVYAFEPELLETIADNAKQDLEKDVLAALIGEGRISAYRTTEYMKDMGTPDRYALVQRHLEDGIVSAKNLSSKQKAIFLDRDGTLNKYVGLVSSPEQLEIEDGVVEALKLANDSAYLAIVVTNQPVVARNLCTEKELGLIHDRLETRLGERGVYVDDIVYCPHHPDKGYPEENVKYKIPCDCRKPSIGMLTQAAEKYNIDLAQSFLIGDTTVDLETGRNAGVTTVLVATGLGGTDGRYSVVPDYEADDLLEAVNGIISGKVLSRSRNANAELCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTC5</accession>
    <name>A0A398CTC5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sensor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_05755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000026">
        <property type="protein sequence ID" value="RIE04509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04509">
        <property type="protein sequence ID" value="RIE04509"/>
        <property type="gene ID" value="D3H35_05755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Sensor" evidence="2">
        <location>
            <begin position="13"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="69" mass="7370" checksum="F33162FAB50B152F" modified="2018-12-05" version="1">MKKRKARAAWTMMVTSLPRGIAWFVIAIVGVCVGLPLAPFIIGLPILAATLKACERLMSERAQAGCDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUA2</accession>
    <name>A0A398CUA2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02564">
        <property type="protein sequence ID" value="RIE02564"/>
        <property type="gene ID" value="D3H35_17915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="161" mass="18060" checksum="FD091531515F4FD4" modified="2018-12-05" version="1">MAKRVKFQIGDLVSIPLENESFGSMVGRILNIDGGSVLLEVYRTHPIANASEFDYDAVKDKRPILIMWCYNKAIKNGSWVIFDRKPVESYGDIYFYSEISTDEFSLTKDNGTVVGELTGVRVSAEEAKKHYPYGISNEIALPRRLKYLLQAEGILSPDSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUL2</accession>
    <name>A0A398CUL2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fumarylacetoacetate hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03547">
        <property type="protein sequence ID" value="RIE03547"/>
        <property type="gene ID" value="D3H35_10915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="209" mass="23057" checksum="08A7B8D55EC2A292" modified="2018-12-05" version="1">MQGGAGLSIEQWIAKTRKVVGIGPNFKAFRAEKGLADSTDSTLFLKSPESLVTGERIELPTRLTEFICEVEMAVIIGKEAANLTEEQALDVVAGYALANDMTASAHFHDGRFKLFDRTTPIGPFVSGIDPMDVTLEMRVNGELVQRDHTSRMLFSVPWQIAHISSMMTLREGDVLLTGTPANPRPCNDGDVIELSSPELGYYKHIIHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV42</accession>
    <name>A0A398CV42_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_09370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03757">
        <property type="protein sequence ID" value="RIE03757"/>
        <property type="gene ID" value="D3H35_09370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="133"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="191" mass="22516" checksum="2AEFB014BC72DDC2" modified="2018-12-05" version="1">MQTNLLLLLGSNFYELNAALQEQLYKQFYNFLYRPVMQLIHDHSATEDIIQETFLTTLRKPPKDVLDEPRFKAWIKIVAKNNVINHLRKTKNYRTDISLESVISMGIPFAAASESVELQAELNSLKEQISLHLKEMRPDHRAVLEMKWKKGLSYKEIADELHETEDTIRQKLFRARMSLKNKLQQEWGKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV50</accession>
    <name>A0A398CV50_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Muramidase (Flagellum-specific)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_07540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04428">
        <property type="protein sequence ID" value="RIE04428"/>
        <property type="gene ID" value="D3H35_07540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002901">
        <property type="entry name" value="MGlyc_endo_b_GlcNAc-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01832">
        <property type="entry name" value="Glucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00047">
        <property type="entry name" value="LYZ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="LYZ2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="228" mass="25863" checksum="212953363E8EAEF4" modified="2018-12-05" version="1">MDRKTFFEKLAPSAVRAREEGSPMFASVRLAQNWLETGGVINKHNNLGGLKAGSGTANEWWKGDTYTAATWEMIGGERIETIETWRSYGSIHDFYRDQDRLLRTSRYARVRAARTPEIQAEALWLCGYATDPAYSTKLIEIMNRNGLKKYDSEKEDEPMTKEEKEAFEALVKRVVALEEEKRLPAPEWFIAEFGSADLGGAIRDPRGTPDFWRAVGVVIRAARKGLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV80</accession>
    <name>A0A398CV80_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03797">
        <property type="protein sequence ID" value="RIE03797"/>
        <property type="gene ID" value="D3H35_09595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="106"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="232" mass="26343" checksum="529E1D2DA89002FF" modified="2018-12-05" version="1">MALLYLLELLSSLRADVTLFNSRDTRKLYPRRKKDRIVHLPVDTRVFYPIDSSEKMADPPTLLFVGGLDSRKRGGWLLELFVTRIRPALPNARLWMVCDPGKPCEGVEYFQHASIEQLAELYRRANVFCMPSTYEGFGIPYLEAMASGTLVVTTPNPGAEELLEDGRYGWIVSDEELADALIRALERPESHAKWTEPALEWARSHDWSVMLQQFLNEEPVIKNADSFAAKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV92</accession>
    <name>A0A398CV92_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage tail protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03181">
        <property type="protein sequence ID" value="RIE03181"/>
        <property type="gene ID" value="D3H35_18040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011747">
        <property type="entry name" value="CHP02241"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010667">
        <property type="entry name" value="Phage_T4_Gp19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38009">
        <property type="entry name" value="PTHR38009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06841">
        <property type="entry name" value="Phage_T4_gp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02241">
        <property type="entry name" value="TIGR02241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="126" mass="14207" checksum="4F45C807C4DE750D" modified="2018-12-05" version="1">MLVAGFSEVFGLEAQTEYEEIREGGNNGFVHRLPKGIRHPSIVLKRGISSSQELWNWYDQASRGALKRKSGSIILYKQDGRELCRWNFFDAYPVKWSGPTLQAASSEVAIETIELVHNGIKAIFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVN5</accession>
    <name>A0A398CVN5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Flagellar basal-body rod protein FlgC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">flgC</name>
        <name evidence="8" type="ORF">D3H35_11355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4 5">The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03281">
        <property type="protein sequence ID" value="RIE03281"/>
        <property type="gene ID" value="D3H35_11355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006299">
        <property type="entry name" value="FlgC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01395">
        <property type="entry name" value="FlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="6">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="7">
        <location>
            <begin position="97"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="147" mass="16388" checksum="913996CCD2854794" modified="2018-12-05" version="1">MKLSGIDISASALTAQRLRMDVITSNIANAETTRAQYVDGKFVPYRRKMVVMEPTQAPFKDLLNDKLTGPSERGVHVTKIQEDQTPFKQVYNPSHPDADENGMVYMPNVDMVKEMTDLISASRSYEANVTALNASKAMFTKSLEIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVX0</accession>
    <name>A0A398CVX0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MoxR family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04027">
        <property type="protein sequence ID" value="RIE04027"/>
        <property type="gene ID" value="D3H35_08725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="41"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="327" mass="35985" checksum="6679B44B41519A2E" modified="2018-12-05" version="1">MSARINGDSIVSAIGQLRSHIGQVIVGKQASIDLLLTALFAGGHALLEDVPGTGKTLLAKTLARSLDCSFRRVQFTPDLLPSDLSGINFYNQKAGEFEFRPGPLFTNILLADEINRATPRTQSSLLECMEERQITIDGDTHPLAAPFLVIATQNPIDNHGTFPLPEAQLDRFLLRIRMGYPTHDESLAILARFRGQNPLENLAPVIDPQTLLDIARFAANEVKITEDLLGYIVRISEASRHHPDVALGISPRGTQALLRAAQAYALVQSRDYVTPDDIKTLAEPVLAHRLLLRQTALGRDERSAETVRSLLRDTEVPAEPAEALERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVY2</accession>
    <name>A0A398CVY2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03371">
        <property type="protein sequence ID" value="RIE03371"/>
        <property type="gene ID" value="D3H35_11880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029261">
        <property type="entry name" value="Transposase_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14690">
        <property type="entry name" value="zf-ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-ISL3" evidence="1">
        <location>
            <begin position="40"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="111" mass="12812" checksum="A4B101934AF13269" modified="2018-12-05" version="1">MQTQYINELLNIPELHVSQILFVDHNELHIAATPVSLLQSCSICLSVQHVIRKGTNGTRTVRHLSVFKRKSFLHVPAIRLFCTTCHTGFGWIYEFVGHKQRYSKMEKTFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWH0</accession>
    <name>A0A398CWH0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_03510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000022">
        <property type="protein sequence ID" value="RIE04908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04908">
        <property type="protein sequence ID" value="RIE04908"/>
        <property type="gene ID" value="D3H35_03510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="168" mass="17486" checksum="7DE8EBCE88BA6C19" modified="2018-12-05" version="1">MLTGAFSALSPAFGLLPFGTFASSSRLAGEYEILNRSAMVIGSGLFFLFGLVPPLGDFLSEMPLSIGSACCSSPICKCSASGRPNDTRPSLRLENDLQAGASDSARHLHHECACGSILRIARLYPASPRSGLIVGIVVSVLGGDDGQLAARRGGKIDRGSGHPRLRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX01</accession>
    <name>A0A398CX01_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_10320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03731">
        <property type="protein sequence ID" value="RIE03731"/>
        <property type="gene ID" value="D3H35_10320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="89"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="210" mass="23335" checksum="D1325305DD36C15D" modified="2018-12-05" version="1">MKWLSRLLGAWGLSLLAAVGFGALAWLVGRDRVHSFDSNIIQVVQGWESPGLTRFMKAFSWIGSTKPAMVIALIVIVFLFVVLRHRKELLFFIVVTGGAPLLNSVLKHTFERERPNLHRLIEEAGYSFPSGHSMASFAMYGALTYLIWVHLPNAAARVTWLIFGAALILCIGISRIYVGVHYPSDIVGGYLASGTLLLACIASFKRYLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX38</accession>
    <name>A0A398CX38_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR03943 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_11035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03564">
        <property type="protein sequence ID" value="RIE03564"/>
        <property type="gene ID" value="D3H35_11035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015402">
        <property type="entry name" value="DUF1980"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40047">
        <property type="entry name" value="PTHR40047"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09323">
        <property type="entry name" value="DUF1980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03943">
        <property type="entry name" value="TIGR03943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="323" mass="34985" checksum="6DDBD9386B9F849E" modified="2018-12-05" version="1">MKNQSSERALAAHHLIRALILGGIAFYIIHLNNGDRLTLYMAPRMIIYVKIAALALYAVAAVQLYHAVRAFTKQAEPACDCGHDHAASASPLKNTLVYGLFVVPLVVLFATSDTTIGSAMAANKGMNLSTSSAIKKQDTAAHPPEAAPTAANEAQPSPETAAPSSADKASPAANGDQPRFPSDPFTEMYAKFAEKLYDEPVIEVKEKDYIETLTTLDLYLDQFVGKQVSIGGFVYREEGMKASQFILGRFAVQCCTADALPYGVIADYPRASDYGKDEWIKITGVLGKTEYKGVTVMKLEVAKIQKIEAAADPYVYPDMDFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXC1</accession>
    <name>A0A398CXC1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MMPL family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_10105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03644">
        <property type="protein sequence ID" value="RIE03644"/>
        <property type="gene ID" value="D3H35_10105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="796"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="822"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="856"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="898"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="925"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="825"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1030" mass="110075" checksum="27F1D35997CA86B3" modified="2018-12-05" version="1">MSAYGIRKGMRRSRMEKWVKWTSRFRFGILALWLGLAAVSVIALPDLQAIVEKTEQKFLPADSESQQALRLLEQLNPDAKSRSTAVIVLSRDGGLKQADKTWMNDLLAGIETDKQRLGIASVLSANTQPELSERFVSKDGTTTIAMVNLPKETFEEDTKETVTELKKLLADSPEGAKASLTGSAPISQDFQQSSQDGLAKTELITVILVFVILLFVFRSPVAPFIPLITIGISVVISRGLIAVANDYGMPVSNFTQSFLIAVLFGAGTDYCILLIQRFREELVKDGDRIAALSRTMRGVGKTIFFSASTVFAAFFLIGFAKFGIYQSAVGVSIGVIVTLIAGVTLAPALLLMFGRAAFWPFRVEQGRGHGDSKLWTAAARFSAKRAGLIIAAAIVLLAPLTLLFQGKRSFDDIAEINPGLSSVSGFRQVEKAFGSGELFPVTLVAEFPSSVRTPEALAAIEQASAELAKRPDVQEVRSAVRPLGRQLTELTVSDQLGKTNDALGELKQGVSDVGSGLSEAQAELSNGRKDVEKLTDGLNQLATGAVQSRDGAGKLAQGLEQSRDGAASLNSGLQGTSKAVSSMKTDIDELLANHPELKNDSNLLAIAGKQQAVAEGLKQIAVGAAPLSQGLIALAPAARQLESGFAKLAEAQRQAAAGSATLEDGLGKLTEGLKQGADGLGRVTDGLDQVRTAQESIAKEGGKQIGGWVLPAEALNSEQLKQALDAYVSSDGKTAKFDVILKSNPYAGESMDATEELTSALRESLGGMTAVAGAKVYASGTTAQYAELRDISFNDFVRTGGLVLAGIALVLMLLLRSVLAPIYVLLSLGFNYFVTMGLMEFLFVKILGYPGLSWTVSFFVFLIIVALGVDYSIFLMARFKEEYRPGGVKAAMAKAMKTTGGVIVSAAVIMGGTFGAMGFSGVDTLVQIGVGTLIGLLLYATVFMALIVPSFSFLLGEANWWPFRKRGTDQVRGPRQPSSNRPIADQLPKPCFTRTKAVLPAWERTAFCLIVRFKISRRTLPESSSCRRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYJ5</accession>
    <name>A0A398CYJ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_04455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04897">
        <property type="protein sequence ID" value="RIE04897"/>
        <property type="gene ID" value="D3H35_04455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="112"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="176" mass="19664" checksum="AD6F1587006BAA01" modified="2018-12-05" version="1">MKVPKETKAGYFVKTIDIPDFSDQSMRAAAGLTFITHIISAGFILASPPANPLFGEIHLGLGCQIAGHVVHFDYDGVTPTPYYVIDTRGNKLQSYLNKMLASFGMPDEQREAQEELASLSNREKEVVELIIKGHTNMEIASLLYLSEVTVKKHLTNIFRKLDIKNRSQLVILMGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0Y2</accession>
    <name>A0A398D0Y2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05151">
        <property type="protein sequence ID" value="RIE05151"/>
        <property type="gene ID" value="D3H35_01915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="253" mass="27128" checksum="146C45A6570B33F7" modified="2018-12-05" version="1">MRLQGKRALVTGAARGIGLGIAKRFLEEGGKVVLLDRSGDELGAAMKELREFGDRVAMEVCDLRDLRQLEETAIRAFDRFGGIDIVANNAGIAFRESFLNISADHWDAVFDINVRAVFRLGQLAARRMAEQGTGGAIVNMSSKNGLAASGELAHYNASKAAVILLTESMAVELAPLGIRVNAVAPGFVDTPLDRQLREQSNLPAYSEYTPMKRGATIEEVANVFLFLASDEASYVTGSTVKVDGGHLANGSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D127</accession>
    <name>A0A398D127_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04874">
        <property type="protein sequence ID" value="RIE04874"/>
        <property type="gene ID" value="D3H35_05265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="188" mass="21015" checksum="11344826811DAAD3" modified="2018-12-05" version="1">MRKLVLFMHVSLDGYASDSNGGLDWIPYNEEIEKYAEEVVAEVGSPIYGRTTYRMMESYWPTVLDNPNASRHSMEHAKWVQDVKKIVISGTMDKVEWNNTVLIKDNIAEEIKVLKEQPGKNLVIFGSPGAAKTLLKLGLIDEFLLTICPVVLGGGKSVFDGGQKIRLKLLSSRTLKSGIIAARYELEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1E8</accession>
    <name>A0A398D1E8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2154 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_00055</name>
        <name evidence="4" type="ORF">D3H35_01215</name>
        <name evidence="3" type="ORF">D3H35_08960</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000011">
        <property type="protein sequence ID" value="RIE05321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000001">
        <property type="protein sequence ID" value="RIE05491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04141">
        <property type="protein sequence ID" value="RIE04141"/>
        <property type="gene ID" value="D3H35_08960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05321">
        <property type="protein sequence ID" value="RIE05321"/>
        <property type="gene ID" value="D3H35_01215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05491">
        <property type="protein sequence ID" value="RIE05491"/>
        <property type="gene ID" value="D3H35_00055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024425">
        <property type="entry name" value="DUF2154"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09922">
        <property type="entry name" value="DUF2154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2154" evidence="2">
        <location>
            <begin position="131"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="249" mass="28316" checksum="1A7CF68F7738B95A" modified="2018-12-05" version="1">MLFRGNRPKRTDRQADHGADGWNSVTPPPVPPNPFQHHGPPPAPPLTDDPAASFTNANGAPVNDPAAYSDERERQSHAQERQQHSDPYRQERDQYRQHYRDERHAHHHGRHWHKDHWKDRWHEGKQSHSRFIGDIFLGNDYWELRPMNISMFIGDTTIDLTKAQIPSGETKLYISSFIGDVKVFVPNDANIGVQVVSSCLIGDVSILDQKRGGLFNQTTVETLSYQDTEKKVVLVVSSFIGDVRVTKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBP8</accession>
    <name>A0A398CBP8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00200">
        <property type="protein sequence ID" value="RIE00200"/>
        <property type="gene ID" value="D3H35_29625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="6"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="128" mass="13610" checksum="137E22890E532E29" modified="2018-12-05" version="1">MAKLTPYIISEDSRAQAAFYISSLGGEVVSVMTHGQMGDASEANKDKVMHLCVAVAGINLFMSDFADHTHGNGISLNLEFSSEGEGLDAYTKLSDGGNVQFPFGPAPWGGFFGQLVDKFGVPWMITAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBW5</accession>
    <name>A0A398CBW5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-synt_1e domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_30045</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00270">
        <property type="protein sequence ID" value="RIE00270"/>
        <property type="gene ID" value="D3H35_30045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1e" evidence="5">
        <location>
            <begin position="16"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="88" mass="10131" checksum="8B35958E8F60F027" modified="2018-12-05" version="1">MTLHIYDSMNRKPEPFVPLTPGKVNMYVCGPTVYGYIHIGNARPVIFFDVARRYLESIGYEVNYIVNFTDVDDKMIRKADEEGITVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCG0</accession>
    <name>A0A398CCG0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_28795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00413">
        <property type="protein sequence ID" value="RIE00413"/>
        <property type="gene ID" value="D3H35_28795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03511">
        <property type="entry name" value="Rhizopine-oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039393">
        <property type="entry name" value="Rhizopine-oxygenase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="75"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="364" mass="42411" checksum="8BB6BFCE5E3532F8" modified="2018-12-05" version="1">MAIVVQKRDYSILGEESRRAEEKGLVAAEWYTSPIPRAKMKELMKRKDGPAIRDTIIWFFGLVVLGYIAYLSWGTWWSIPAFLAYGMLYATPADSRWHECGHGTAFKTPWMNEVIYQIASFMVLRSATPWRWSHARHHTDTIIVGRDPEIVTERPPLWKILWMQMFDLYGGPVEIKRFVMHAFGKLEAQEKEYIPQSEHKKVFREARVYMLIILAVIAACIYFGSILPAMFIILPSFYGFILVLGFGMTQHLGLYEDVLDHRLNSRTIYMNPVLRYLYWNMNYHVEHHMFPMVPYHALSKLHEEMKADCPPARPSFSAALKEVVMALKKQKLDPHYVVVKPLPSTARPYMYGIEHKSNLRSDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCL1</accession>
    <name>A0A398CCL1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dihydroxy-acid dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_28515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00460">
        <property type="protein sequence ID" value="RIE00460"/>
        <property type="gene ID" value="D3H35_28515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009082">
        <property type="term" value="P:branched-chain amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="565" mass="61380" checksum="8C5A784B5F963B29" modified="2018-12-05" version="1">MKSEAYFQEKDLWGFIHRSFTKSMGYTEEDIRKPVIGICNTFSELNKCHSHFNELVDYVKRGVWQAGGVPMEFPTISIGEPYVKPTTMLLRNLMAMDTEEMMKAHPIDGVVLIGGCDKTVPAQLMAAASANIPAIVLTGGPMLNGRLGGRSLGACTDCYGFTLEHKAGNITDEELAVAENAICRSDGHCMVMGTASTMASIAEAIGMALPGCAAIPAPDSRRRHISERTGKQIVELVRRDIRPRDIMTAEALENAIRVTMASGGSTNAIIHLVAISQRLGRKLPLEKFDAISAETPFILNLRPSGKYQMEEYFEAGGVPALMKELEPLLHGDCLTVTGMTVTENLANARTLDRDVIRTMAEPLDSQGGIAVLRGNLAPDGALIKQTAVSPQLKKHTGRAVVFESPADLNARIDDPELDVDENSVLVLKNAGPKGAPAMPEIGQIPIPQKLLVKGVRDMVRISDARISGTSYGALIVHAAPEAAVGGNLALVKDGDEIELDIASRKLELKVSPEELAERRKSWVAPEPHYDRGYGLLFHERVLQANLGCDFDFLLPKELRKELLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCW9</accession>
    <name>A0A398CCW9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="4">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pssA</name>
        <name evidence="9" type="ORF">D3H35_30000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00265">
        <property type="protein sequence ID" value="RIE00265"/>
        <property type="gene ID" value="D3H35_30000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE00265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="247" mass="26799" checksum="E0A64DE8A6882FCB" modified="2018-12-05" version="1">MITKSIPSLFTVGNLFLGVISIILAFNGQANSAALLVIIAMLLDGLDGRVARALNVQSEFGKELDSLSDVISFGVAPAFIMYQAAFQNQVSSEALAWIVTAIFPTCGALRLARFNVIAGIPGYFIGLPIPAAGGVLATLALFHGELNVYLLLISTLALSFLMVSNMKYPNFKKLGLPRAAMWAIPIVVAAAAVLAYLFQEAIPKVILALLLLYAMWGLKKNVERLVPRRYRKKKNYSDEEPRSKHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDA6</accession>
    <name>A0A398CDA6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_22445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01166">
        <property type="protein sequence ID" value="RIE01166"/>
        <property type="gene ID" value="D3H35_22445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="177"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="279"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="545" mass="62825" checksum="ECD49A0397233E6E" modified="2018-12-05" version="1">MRTRTVENDFLKGTMFEIVEARCDNQPPDWMKRLKSIKHHALIFLDAGTGTLIVNGHPSKLIRDSFYMYAPGTRLELQLQPGSGLKLYAVMFDLFRTVAGSDYQRSYVRDLTFPFQGQHRMSGGRFKRLCRLLTSEGEALLERRRFLGQQYLYDILDDLLNAASIAADEDDVETRLNRSISYILRNYREDIRVDKLAGLARLHPTYYTHVFKQSMRKPPVSFLTDLRMSKAKELLLLTNKPIRDIARDVGYEDEFYFSRRFKKTSGIAPNSFAKKDDMRVVSLSFPYTDHLHTLGIVPSAAQLHPFLPIQTVALKLPEHAIDPWEIDRQVFIDAQPDLILCKDNVLPRARENINDIAPIISIPWSGEDVYSHLSNIAELVNKQPEAKQWLELHERKSERLRARVRHAIGQSTVTICVARGEKLRIYGARNIGHVFYRSLRLAPPDAVAKRMKPYPAGTIHNWIAIQEDELIHYESDFLFFVVGNEEDLKRVHRLIRTSSSWMMHPAVRANKIGFLNWDKWMIYAPSMLDVQLEAAAQLLTGSAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDT7</accession>
    <name>A0A398CDT7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">HlyC/CorC family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D3H35_27860</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0053 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00595">
        <property type="protein sequence ID" value="RIE00595"/>
        <property type="gene ID" value="D3H35_27860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="4"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="226"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="289"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE00595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="446" mass="50309" checksum="2CCB7F9E1ED491EE" modified="2018-12-05" version="1">MDSDPFPLVVDLILIVLLVFLNGFFVAAEFAMVKVRGTRIDTLVQEGNSRAKLASRITNHLDAYLSVCQLGITLASLGLGWLGEPAISRMLEPVFEWLDIGESYVHPVSFLVGFSVITVMHIVLGELAPKSFAIRKAESVTMWTAIPLIGFRKLMNPFIWLLNGTANLLLRPFGIDTSEVSSSAHTEEEIRILVKESHKSGLIDNNEMTLVDNIFDFSDTTSREIMIPRTEMTCLYGNLTYEENKEIALREMHTRYPVCEKDKDNIIGFVHIKDLLKVADGSITDIRQLTRPITTVPESMPISALLKLMQKRKTQIAILIDEYGGTSGLVTLEDIMEEIVGEIQDEFDEERPEIEQKEDGIYSINGLMLIEEVNSFFNLDIPTDDYDTIGGWIYSQIEIPPKKNQSVHTEDGSYRFTIEETDHLRISRVTVSREANAEWEPEAETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE91</accession>
    <name>A0A398CE91_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Copper amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_25660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00950">
        <property type="protein sequence ID" value="RIE00950"/>
        <property type="gene ID" value="D3H35_25660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017320594" evidence="1">
        <location>
            <begin position="36"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="NAGPA" evidence="3">
        <location>
            <begin position="228"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="2">
        <location>
            <begin position="762"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="2">
        <location>
            <begin position="792"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="884" mass="94611" checksum="D3246957D2A4E2D5" modified="2018-12-05" version="1">MRSKWKKALGTLLITTVTATSVTVISVPQLTYAEAATTAADQLILNSESPITSGATLRSYTWKSTRNKKAISVNAKVIAVDLTNPNVKLDVMTGSGEQFTKKQTIAGMAKEYGAAAGINGDFYNTKADGAPMGPQVSDGVVMSTAPLLAGYYSFAVTKDRKPLIDTFSFSGLVTAADGASFNLNGINKAVYWYGKPSVHAMNDSMFIYTSAWGSTLRAVDRNTDLLEVLVVDGIVQQIQPGAIKAIPPENGYILRTEGKARKFVLEHMKVGDPVSYTYQMIGSEFKPQADASQFNVMIGGGTLLVDKGKPVETLSLPNDADAKSARSRTSVGFSADQKFVYLVTADKTGSSSDGVTLKELGKLLAQIGVWRGINLDGGGSTQLVSRPLGDTTAVIANGLENNWQRPVVNGLGVFSTAPKGQLAGLIVSGAKFVLKGEQATFSLKGYDQYDNPVDAADLANVSWTTTDKKAAMEAGVFTSSSAGKTKVTASLGGVSQNYDVQVIGRDDIQSMSVVTSSSVAITNSSIKLSVKVKTKSGAERTLPGQLFSWELQGIEGQVTDNILKVSSVKDSAAARIVAHYDGYGATATLPIGVVQTIADWDSPATDLATAFASTAGVTGTVANIAVEGNEQNRAIELAYDMTTGTTDTKAAYVSFPKGVALSGQPQKIQMQVRGDQSLNWLRAEMIDADNKLYYIELEPTVNWKGWKTVSADLAGLKMKYPVKLNKLYVASPKVGEDERNPIGSVAFDQISFLYKQAIPGLKQNTAKLTLGKKKIEVNGVAATIDVAPLTVNGRTFVPLRFIVDALGGEVQWDPVDKRITVFRGSQMAEMRVGEKDMIFNGQRVTTEAAPISKNARTLVPLRLLSEQFGWIVDWNDKTKEITLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEI7</accession>
    <name>A0A398CEI7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01123">
        <property type="protein sequence ID" value="RIE01123"/>
        <property type="gene ID" value="D3H35_22155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="398" mass="45478" checksum="4D9E6B994BF5A294" modified="2018-12-05" version="1">MNAFEYAAAQMKSDVERFGLQQSALAHQSPKVRYLVTLMSALAHQSPKVWYLITLMSVPAHQSPKVWYLVTLMIALAHQSTKVWYLVPLMSVPAHQSPKVWYLVPLMSALAHQSPKVWYLVTLMSIPAHQSPKVWYLVTLMSALAHQSPKVWYLVTLMSVRTHQSPKVWYLVTLMSALAHQSPKIWYLVPLMSALAHHSPKVWYLVPLMSVPAHQSPKVWYLVTLMSALAHHSPKVWYLVTLMSALAHHSPKVWYLVTLMSVPAHQSPKVWYLVTLMSVPAHQSPKVWYLVTLMSVRTHQSSKVWYLVTLMSALAHQSPKIWYLVTLMSALAHHSPKERYLVTLMSVPAHQSPKVWYLVPLMSALAHQSSKVWYLVPLMSALAHQSPKVWYFVPLMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEM7</accession>
    <name>A0A398CEM7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iron-siderophore ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_21900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01080">
        <property type="protein sequence ID" value="RIE01080"/>
        <property type="gene ID" value="D3H35_21900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017230506" evidence="2">
        <location>
            <begin position="33"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="75"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="345" mass="37474" checksum="8F616C012050E316" modified="2018-12-05" version="1">MRLFKLSSVLLIFSLLLVIVGCGKNEGSDASAQGSEKPASTASASSSPEAAPAADEVRVFEHSMGKTEIKGTPKRVVVLEWTYGEDLLALGVQPVGFADIATYKQYVNIEPQLGADVVDVGTRQEPNLETIASLKPDLIILAHFRGQESYPLLSKIAPTLVFNSYPEEGKGDQYQEMVDTFKTIADVLGKKAEAEAVLADLDKVYADSKAKLESAGKTDKPFVLALAYSNQNAVQFRLSTDNSLAVKILEHIGLTNAYKPAKFEVYGFSTTDVEALPPVQDANFIHMIQESDNVIENQLKDNAIWKNLSFVKENRVYALGGDTWPYGGPLSAKIIAGKIVDLLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEN1</accession>
    <name>A0A398CEN1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribokinase</fullName>
            <shortName evidence="8">RK</shortName>
            <ecNumber evidence="8">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">rbsK</name>
        <name evidence="12" type="ORF">D3H35_25120</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + D-tagatofuranose 6-phosphate = ADP + D-tagatofuranose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12420"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58694"/>
            <dbReference type="ChEBI" id="CHEBI:58695"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.144"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; D-tagatose 6-phosphate degradation; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate kinase PfkB family. LacC subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01626">
        <property type="protein sequence ID" value="RIE01626"/>
        <property type="gene ID" value="D3H35_25120"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00704">
        <property type="reaction ID" value="UER00715"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009024">
        <property type="term" value="F:tagatose-6-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001059">
        <property type="term" value="P:D-tagatose 6-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005988">
        <property type="term" value="P:lactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="D_ribokin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02152">
        <property type="entry name" value="D_ribokin_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0423">Lactose metabolism</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="11">
        <location>
            <begin position="2"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="37"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="219"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="250"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE01626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="309" mass="32814" checksum="4F12F404C1CFAF9D" modified="2018-12-05" version="1">MITVVGSTIMDIVFTTEHYPKRGDTVFGKDIRYSPGGKGANQATACAKLGVETYLIGCVGDDSFGQTMLLNLQSNNVNIDFMKTVNDARTGTAHVTVDSSAENTILVIKGANESLTVEDIHSCEEIIGKSKILLVQMEISGEVTTQAMLAAKRHGVTIILDPAPADGIHIPSLQYADIIVPNQQEAKFLTDIEVHDIPTAVEAASYLHRQYGIARSIIKMGGLGSLVYQDGAYEHIQAVSVQAVDTVGAGDCYAGALAYALADGKTLPDAAKFASIVSALKVTKYGAQDGIPSMDEVKAFCLARNLTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEX2</accession>
    <name>A0A398CEX2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_23070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01273">
        <property type="protein sequence ID" value="RIE01273"/>
        <property type="gene ID" value="D3H35_23070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="727"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="781"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="816"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="19"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="278"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="756"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="856" mass="93353" checksum="7D6D64245E79E80F" modified="2018-12-05" version="1">MIGYGALAGRYLKQQRRKSTLTVFGIILSVALICALGTMGQALKDNLLKQQMYEDGSWHFAYTPNSAELYDKLSHHALVDRTGALISGDITALADDYKIAVNDANADALQLLPIHLAEGRLPAAPNELAAEQWIVQRLPGKPKLGDTVRLNGPDGQLRDYALVGTLKNGRQSQVEGVGAAYAGLDDAKVASIPGKTSLQLYVTLREGADISRHLPEFEKLDGSFRDNNQVLALMGESSSNDLNQALAIIFGTLVGLVVLSTVAVIYNSFHISVLERIRQFGLLRTLGATPRQIRNLVLREATTLALIGIPFGLAIGWGGLYLVLWLMIQGGFQILQMENFHLTFHWWIMGLSVGVGIAAVYMAAWLPARKASRVSPVEAVKGAGSIVRESYRRARIPSPLHSLGVEGKMASKNIRRNRTKFRITTFSIVVSITLFIVFHYFAQQVFDTAIQSNEDNRISFELQRTNMSFRVNDDGTVPPVQDIVPPETIGQLEAMPGVDDVYGNYQSPVAKVLVPENKVNSRAEEVGGIHFVRSDWDGGVRAIVPTMLTLYDEARLKEAAKYVESGSADPKLLAEENGVLIVQTAKPYSKQSKKLNQLDLTTYKVGDTLTIHMGESDAIQSSTVREVKVAGILSESPFGSRYLDHGLTVIAAKSTFAMLLDSVPAAKNVPVYGTALLGLEIALKEGADTEPVKLKLEQIAAGIKGSQVIDIAAEQAQERQFGLQMKIFIYGFLGIIALIGSLNIINTVQTNLFLRRREFGLLQAVGMTMGQVRKMATTEGVWFGIIGSIWGLLCGGLLSYFLFVQMSNVQGMPFDFPWGGAAIACGFAICVGLLSVQGPLRRMQKANLIDTLREEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF45</accession>
    <name>A0A398CF45_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_13560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01816">
        <property type="protein sequence ID" value="RIE01816"/>
        <property type="gene ID" value="D3H35_13560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="232"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE01816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="438" mass="49339" checksum="6B5DDACCC5809A9C" modified="2018-12-05" version="1">MLICSGYLNRRQRRSWISLCLIALTTGTLIVAYSPLPYIYFEDYGNVLLIFFDISMFVLFPALSTYIDDVFEGRFVYFKKFRRFQTAYSAFCLAALCLYKATDGKYYALYDFFSNTILGPLILIQLIFIIVLAVRNAINGNKNAAILSVGIFLLALSGAADLTIYYLSETRYVLFLWKFGIIIMIVTLVVILARRISADYAMLVTYSKELELYNHNLQRTEKMKIISDLAASVAHEVRNPLQVTRGFLQLLSEKSDLENKNYFGMAINELDRASTIITDFLTFAKPEMETLVMLDLSEEIKKIEGIMSPLAALHGGILVIDIPENLHIYGNSSKLKQAFINIIKNSIEAIGKDGVIGIYAYSTERDVILRISDNGEGMEEEKLASLGEPFFSTKSKGTGLGLMVTFRIIEAMKGSIEFRSTKGKGTEAIIRFPLIKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFV7</accession>
    <name>A0A398CFV7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4073 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_15050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02076">
        <property type="protein sequence ID" value="RIE02076"/>
        <property type="gene ID" value="D3H35_15050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025142">
        <property type="entry name" value="DUF4073"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13285">
        <property type="entry name" value="DUF4073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017309463" evidence="1">
        <location>
            <begin position="34"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4073" evidence="2">
        <location>
            <begin position="683"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="754" mass="78416" checksum="EDBD7EADBEA57165" modified="2018-12-05" version="1">MRYFNHYKRKVSSMLVAALVATSVSVIPAAVSAAGAPVVNYVNETVTGVTYDVAHQYSVDNGATWKEVKVSGVDVGSVSIVPGTNFKYRLSTTGAGTSLTVPARPVAPASALNSTTETIGTATGIQVSLDGGSNWSSTVTGATYDVSSLIPASNGTNLVVKVRKAATSTAFTSVTKDITLYKRAATPTATFNPSTVKIEGAGVTTAAEYSTNGTLWNKITGTTIDATNIVPASTVTASTYVKLRIKPTSTASASQQLSIEIKPRGKSPINAISGTANDPAFSVTTEELINVDNTMEYAVGASTTYTAVTGTKIDLSSKLGTANTTVKLRYKATSTNVASDADSISLAKRATTPTAVAVDFTKEQVKNLVSGSHEISADGVTYSSVSAATYDVTNLIPSLSTTAKNIYVRVKATSSVPASAPKVVSVVREATPLNTVVKFNPTTETITASTKLEYSLDKTVWTAGAASIDAKSLISSSVTVDVYVRTKATTTKFHSDNLIVTLPKKGTDPVDGVSGGPSLSFATEKLSGLTASHQVTLDGGKTWFDGNDAKKVVSGVVDLKNVIPVSTAKALGKVGVRFKASGSTVSSAVYYYTLPIREVKPVVVAFYPTNTIYGVSDKMEYSTNYNAKTGAGTWTAITGSTLDFTSLLSTTAVVKVSIRVKATGTAPASDIASVDLAKVAAKPTTKQISANDTDNVIVGITNAHEYSLDGTTWTTFNLVSPPVLSGNKTVFVRVKATDKAPAGDKIQLTFTTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG68</accession>
    <name>A0A398CG68_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal-sensitive transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_24160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01455">
        <property type="protein sequence ID" value="RIE01455"/>
        <property type="gene ID" value="D3H35_24160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="86" mass="9666" checksum="7FD563308432701A" modified="2018-12-05" version="1">MEYNSQIQNRLKRIEGQIRGVLGMMEEGKDCRDIVTQLTAIRTAVDRSIGLVIGSNLEHCIQDELKNGNSPDKVIQEAVELLVKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGB3</accession>
    <name>A0A398CGB3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01540">
        <property type="protein sequence ID" value="RIE01540"/>
        <property type="gene ID" value="D3H35_24630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="3"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="154" mass="17334" checksum="A06491F4EC577DEF" modified="2018-12-05" version="1">MSVITYVNFDGNTEQVIAFYSEALHASEVKKVKFKDIPQDPNYPLPENEQNMIMESSLEFAGGKIMMSDILPSMKQVTGELVKGNNILISIVIDDKEALQNYFSNLSVGGYVIMPLSEMPWSSCFGMLVDKFGVTWKFNSDADKFLDRVLSNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGD9</accession>
    <name>A0A398CGD9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_24735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01560">
        <property type="protein sequence ID" value="RIE01560"/>
        <property type="gene ID" value="D3H35_24735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="328"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="362"/>
            <end position="369"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="579" mass="66005" checksum="1414A93399F9627E" modified="2018-12-05" version="1">MIKVESLSFSFPQKELYKNISFTLEEAQHCAFIGTSGSGKSTLVDILLDPERYLFEGKLEIDPTCKMGYVSQFSPLDRTKETTVFEYIGDKYIKIQNEIQTICTEMETSSDIEPLLEKYQLALDAFDSIGGEDFESNINKKLNLANLMKLKDVRVSDLSGGEFKLIQVMKEMLGSPDLMIMDEPDVFLDFENLNALKNLINAHKGILLVVTHNRYLLNHCFNKIIHLENTEIQEFDGRYMEYNFSLLQTKMELQELAVAEEEEFKRNEKIINNLRAIATFNADASKGRALKARVSFQARLEARRIKAPFVDIKEPNISFGIDNEIEDMTVINVSNYSVAFDQLLLDNVSFEIKSTDKVAIIGPNGTGKTTLLRDIFNNNHDSIEINADAKVAYLSQIQGEMLKDSNTILEEFIDAGFNTYDEIRSYISHYGFEGEIVNQKIESLSGGEKNILQLAKVSTSKANVLLLDEPTSHLDTYTQIALEKAIEAYKGAILMISHDFYSVVNGMDYVLIINDKTIRKMSMRKFRQMIYASHFDKDYLETEQNKKAVEMKIELALRNTDFELAKGLVDELEELIKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGG3</accession>
    <name>A0A398CGG3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_24860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01580">
        <property type="protein sequence ID" value="RIE01580"/>
        <property type="gene ID" value="D3H35_24860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="227" mass="26388" checksum="1E3064E73AFD749C" modified="2018-12-05" version="1">MKKQQPQISEDKILEASWALLGEEGIEKFSLRRLADRLGIQAPSLYWYFKSKQNLYYRLANQVSKMILEEFHSEGDWKEQMTELAITVRSVLSRYPCSTQLMMLTLPHEPDIIRFTNRMLLCMESTPLEQEQKLQAVLTLANYVFYFVLDDYEHQRNVSAILKEQGDNLPSGEMIHLLDSMSESEAGLFRRMYKSGLFEVMGTDGAFEFGLKLILLGIEQVIKEQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGU7</accession>
    <name>A0A398CGU7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_22545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IucA/IucC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01182">
        <property type="protein sequence ID" value="RIE01182"/>
        <property type="gene ID" value="D3H35_22545"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="PTHR34384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IucA_IucC" evidence="3">
        <location>
            <begin position="138"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="FhuF" evidence="4">
        <location>
            <begin position="385"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="561" mass="64768" checksum="F94F659F26424C68" modified="2018-12-05" version="1">MLETGKSRRLDSLQQANRHTCKTLLNCYIREFCHENTNVFVVNPQEKTYTISFPASDIALSGKLSFYSAIGEHEYDHYRVNNGQELYYAHLVQWIVKELRQHSFITTEKEEDFSNKIANSYRNLALFLEHSAHSRVRDYLSSEQSLLCGHPFHPFPKNTMGFSEDDVRTFCPELHASFRLCYAAVRKDIFREEWVSEQRRIELHESVKTHARQALQEQSEGYEILPIHPWQYEHVQTIGIVKDYIRERKIVLLGSCGPLAYPTSSVRTVFIPDMKCNIKLSLNIQITNMTRNNNKEQMRRTLDAAGYLKRRDCFAKEPNTQIAYEEGVCTCHFDDDETTKLFTIAYRPIAFDTTSTYVLSSLVEAPVRGAPSRLFSLMDRRHVDRWFRQYLAISLLPIVRIAEEKGIHFEAHLQNALLTVKNGMPHTFIIRDLEGVSVNREKAEEAADTAGPLFYSKEAAWARTSYYFVVNHLGSFIHAMARDARVEEEHFWEIVRDVLVQEYEKSGNEYVRHLLTADAFYAKKNLMSCLAGNSEAPSYVPVNNIMKNIGSEISGASKQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGU9</accession>
    <name>A0A398CGU9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01973">
        <property type="protein sequence ID" value="RIE01973"/>
        <property type="gene ID" value="D3H35_14480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="158" mass="17535" checksum="2A652B3138A49DCB" modified="2018-12-05" version="1">MSTPTVAKVRFVSPADSDLAYLIGRLDEDLLRRYPAESVHGLDFADPRIDDIAFVVAYLNGTAIGCGAIRPLDEKCTELKRFYVEPECRGTGVAASMLLELESEAGRRGFESIRLETGALQPEAIRFYEKNGYAPIPPFGEYVDCELSLCYEKDVRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH17</accession>
    <name>A0A398CH17_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01760">
        <property type="protein sequence ID" value="RIE01760"/>
        <property type="gene ID" value="D3H35_13230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="573" mass="63391" checksum="4FB4923409BB861C" modified="2018-12-05" version="1">MAHDRKGISMRNIASALRPLRLPRPLLTLTLALLLALTGCIGKEQSPDSEPSESASAADGGDCGQPTVISTAKALREYDILRYEDTTENNPITRWARNKLCIVQTNKWMVTDQDNALSDRIRTALSNGEELPDVLFVTNHELPSLLRDLIDADRLQEMGSVFEKYAPARIKEAYALNPDVWKTVTLNGQRWGLPQISDGKLGDPILWIRQDWLDTLDLKAPTTIDELEKVMDAFTHGDPDRNGIDDTVGIAVAGQNTLNGWMGDVSFLFGALGDQPHQWNRTADGSLAYGSVQPSVKSALTRLAEWYEAGYLSKDFGTHDEQEAVALVTSGIAGIISGPGWMGGWPLGESGLDFKPYPYPHGEDGRIGRIGTLLSYGSYLFRKGFEHYDKIFAYYNEVYGSLIEDPKSDFAIGLAEGYDYRIVNGKPVYDFPGASSTIGNFFLVAPGSAPPHVMRGDSIERRVFNGQTDSYYEQKLAGTTSRLFLEGRIVGEQQAGISRPEQFVGPQTPAMSRSWRLLDKMEQQTFLKIVYGHSSPDAFDRYVSDWYAHGGTEVTAEVNEWDLESGLSAYTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH60</accession>
    <name>A0A398CH60_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_15085</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02083">
        <property type="protein sequence ID" value="RIE02083"/>
        <property type="gene ID" value="D3H35_15085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="18"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="266" mass="30943" checksum="0EA320F63BC4740E" modified="2018-12-05" version="1">MSTLYSMLKETVKNRRLVYELAKKDFRAKYLGASLGIIWAFVQPMIMIAIYWFVFQIGFRSVPVENVPFVLWLMAGIIPWFFISESFSSSIHAITENGYLVKKVVFNVSLLPLVKIVSALFVHLFFIGILFLMFISYGFAPSLYHLQVIYYVFASILFATGFSWLASSIVVFIKDVGQIVAMLLQFGFWLTPIFWSLNIVPDKYRFILKLNPVYYLVEGFRSTFIYHKWFWETPSLTLYFWVVTAMLLAAGAIVFKRLRPHFADVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHB1</accession>
    <name>A0A398CHB1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000061">
        <property type="protein sequence ID" value="RIE00288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00288">
        <property type="protein sequence ID" value="RIE00288"/>
        <property type="gene ID" value="D3H35_29385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="184" mass="20236" checksum="B27B5ED81B920D04" modified="2018-12-05" version="1">MPDDQLRSVRLAGQRIRPAVQKPYIARAWLLVLPHSDVSPVCTDLVRAARSGELRPRDILGKPLNGAKLVVIEEQVLVPVCISACQIRRLRREQDHRAVKADERRVAVAVRLNASGREANPFGRSAACGLRAGDILLALVRRTARAERPNGLARGGGVQADGDSYAPFVSLDGSMVLLRRRRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHD2</accession>
    <name>A0A398CHD2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper-exporting P-type ATPase</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Copper-exporting P-type ATPase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cu(+)-exporting ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">D3H35_15555</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + Cu(+)(in) + H2O = ADP + Cu(+)(out) + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25792"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02163">
        <property type="protein sequence ID" value="RIE02163"/>
        <property type="gene ID" value="D3H35_15555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00003">
        <property type="entry name" value="TIGR00003"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-0187">Copper transport</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="762"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="785"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="11"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="79"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RIE02163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="812" mass="86390" checksum="7F39495A57CA8B21" modified="2018-12-05" version="1">MQSAQGQDTKQTTMQITGMTCAACANRIEKGLNKLEGVTAANVNFALEKASVTYDPVKVDVGRLEDSIRKLGYDTAKETVDFQLEGMTCAACAARIEKGLNKLPGVKTAAVNFAMETAHVEFSPGEVSVHDMQTKVKQLGYRAILKEEVSAASGDYREKEIKKHKAKLLLSALLSLPLLWTMVGHFSFTSWLYTPDILMNPWLQLLLATPVQFYIGRQFYVGAYKALRNRSANMDVLVSLGTSAAYFYSLYQTVDWALDSSMHRHGPELYFETSAVLITLVIMGKLFEALAKGRTSEAIKSLMGLQAKTALVVREGVEQTIPVDEVIAGDIVLVRPGDKIPVDGIVVEGSSSVDEAMLTGESLPVSKTAGDSVIGATINKNGALQIKATKVGKETALAQIIKVVEEAQGSKAPIQRVADVISGIFVPIVVGIAAIAFVVWYFFVTPGDVPNALEKAIAILVIACPCALGLATPTSIMAGSGRAAEFGILFKGGEHLEQTHKIDAIILDKTGTVTKGKPELTDVLAEGETDEFLALVGTAEKNSEHPLAEAIVAGIADRNIALSAAEQFEAIPGYGIKAVVGGKSVAIGTRRLMERDGVDAASAYESMSRLEEAGKTAMLVAIDGRYAGMVAVADTIKETSSEAVRRLKEMGIQVIMITGDNERTAKAIAAQVGIDSVLAEVLPEGKAEEVKKLQRQGKIVAMVGDGINDAPALATANIGMAIGTGTDVAMEAADVTLMRGDLSSIPDAIYMSRKTMANIKQNLFWALAYNTLGIPIAAIGLLAPWVAGAAMALSSVSVVLNALRLQRIQVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHM9</accession>
    <name>A0A398CHM9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-E domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01940">
        <property type="protein sequence ID" value="RIE01940"/>
        <property type="gene ID" value="D3H35_14295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007296">
        <property type="entry name" value="DUF403"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04168">
        <property type="entry name" value="Alpha-E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-E" evidence="1">
        <location>
            <begin position="3"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="319" mass="36700" checksum="A47C3BB66E5B01B8" modified="2018-12-05" version="1">MSMLERIAESLFWIGRYTERAENHARLLDVYYHLREESDASGDTVWKRIAEAIGDTALYEERHEAYRERDVIHFLTLDTAQGNSLLCCVSHARDNLKKIREQLPAELWNLMNGFYLWLKSVKLDEVLQDSPHGFFQKVKEGLAAFQGTAVSIVVRDESWHLMEIGRYLERSENIVRLLQSVRRTLPDSKESSYGYTMALLKSVGGAEAFRRLGLVEMSLEEVCRFLVLQETFPRSVQFAIASFENRLKSLRGQADKSGSELERVIRLAGKTRSELGWLERHDLTLDNLDSVLQQLLSSNRQLGDAMDKYFFSPGREVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHP4</accession>
    <name>A0A398CHP4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_24530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01522">
        <property type="protein sequence ID" value="RIE01522"/>
        <property type="gene ID" value="D3H35_24530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="91" mass="10601" checksum="B0EFB31EA73CA7AB" modified="2018-12-05" version="1">MDNERTAKHTALIEREDDLLSQIDTCQQLIAAFWRFLLSLDEEVHLPTARRLMIALNNVERSIEEEMLDIRLALLSFTFSRKHAPPEGTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI06</accession>
    <name>A0A398CI06_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF386 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02423">
        <property type="protein sequence ID" value="RIE02423"/>
        <property type="gene ID" value="D3H35_17100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004375">
        <property type="entry name" value="NanQ/TabA/YiaL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037012">
        <property type="entry name" value="NanQ/TabA/YiaL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34986">
        <property type="entry name" value="PTHR34986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04074">
        <property type="entry name" value="DUF386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00022">
        <property type="entry name" value="TIGR00022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="145" mass="16477" checksum="B9B2A12A1A575A21" modified="2018-12-05" version="1">MIYDKIANADLYAFRHAGLSGAMEDLKINQLGNADSTLFQKNTSQFVTVPLSEKQYEAHKKYIDIHVVLEGKEYVEISHIGCMTNETAYDETRDIWFGDVAAESKFQGHLEPGYFLVCFPEDTHLVGAHKEEETDVKKIVYKIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI76</accession>
    <name>A0A398CI76_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02150">
        <property type="protein sequence ID" value="RIE02150"/>
        <property type="gene ID" value="D3H35_15490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="213" mass="22768" checksum="169786675D7E379A" modified="2018-12-05" version="1">MKIGIIGATGKAGSLIAKEALSRGHEVTAIVRNPAKVTDSGVSVLAKEVFQLTAEDLKPFDVIVNAYGAPHGQEHLHVEAGRVLIEAVKGTPDTRLIVVGGAGSLFVDEAKTIRVLDTPEFPQEYFATASNQGKNLEDLQASSGLKWTFVSPAGFFNPEGKRTGAYRKGKDNLILNSQGNSYISYADYAIALLDEIENPAHIGERFTVVGEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIB5</accession>
    <name>A0A398CIB5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YceI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_17450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0312 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02483">
        <property type="protein sequence ID" value="RIE02483"/>
        <property type="gene ID" value="D3H35_17450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="2">
        <location>
            <begin position="59"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="229" mass="24879" checksum="F4468743AD4575BD" modified="2018-12-05" version="1">MNRKLGIALVLGAGLLLTVCYVGYDYYAGNHVEVKPVIQPNVEETGEAPQPLSLADVSTWKVDTSSEVYLIVSTSKEKVNLKAGEVTGDWSLSLKNPSDSKASATVKLDVLDSGNSRRDVHIKGPEYLDTGAYPEAVFASETIENWPSDLKAGQLFQFQMKGRLTIKGISKDIAFAMEGTIEDDKIALEGKTTITFSDFGMKSPSAVFSKTDEEIEIEPRLILIPAAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIS5</accession>
    <name>A0A398CIS5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02285">
        <property type="protein sequence ID" value="RIE02285"/>
        <property type="gene ID" value="D3H35_16300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="81" mass="9169" checksum="04514EDD4F300E06" modified="2018-12-05" version="1">MNDFLERLLKYGNYKVSLSIGKWKGGLSFSSAGRAYNFDPAVIWLSRRANHRNKAEFRAISPLTDGASDNRLYSQIVRSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIT5</accession>
    <name>A0A398CIT5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3905 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02295">
        <property type="protein sequence ID" value="RIE02295"/>
        <property type="gene ID" value="D3H35_16360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024999">
        <property type="entry name" value="DUF3905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13045">
        <property type="entry name" value="DUF3905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="146" mass="16719" checksum="F5E5C871B9BE8A0A" modified="2018-12-05" version="1">MNNNEENRSSYEGMKPVEGGNSELDPFEIEFLPEHRHGRGPRAPFVNEYGVVIGDHDYESAESPLEQWSENTDPAVMSGDQWVHPYKDIGFRTSENRDRFERGIRPFSGVFMHPTHQTSSSDEVYTDNLGDPDDEFFPVPEVLDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIV6</accession>
    <name>A0A398CIV6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-rhamnose isomerase</fullName>
            <ecNumber evidence="3">5.3.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">rhaA</name>
        <name evidence="4" type="ORF">D3H35_26785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-rhamnopyranose = L-rhamnulose</text>
            <dbReference type="Rhea" id="RHEA:23160"/>
            <dbReference type="ChEBI" id="CHEBI:17897"/>
            <dbReference type="ChEBI" id="CHEBI:62346"/>
            <dbReference type="EC" id="5.3.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; L-rhamnose degradation; glycerone phosphate from L-rhamnose: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the rhamnose isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.14" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00798">
        <property type="protein sequence ID" value="RIE00798"/>
        <property type="gene ID" value="D3H35_26785"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00541">
        <property type="reaction ID" value="UER00601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008740">
        <property type="term" value="F:L-rhamnose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00541">
        <property type="entry name" value="RhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009308">
        <property type="entry name" value="Rhamnose_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06134">
        <property type="entry name" value="RhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01748">
        <property type="entry name" value="rhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0684">Rhamnose metabolism</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="421" mass="47665" checksum="C9D392243A7DA656" modified="2018-12-05" version="1">MQPNIERNYEAAKQQYARHGIDVDKALEKLATIKISMHCWQGDDVRGFLNRDQELSGGIAVTGNYPGAARTPAELRADLEKAFSLIPGKHKVNLHAIYADTDEKVEWDQLAPRHFQTWVDWAKSQGLGLDFNPTCFSHDKASEGFTLSHPNPEIRRFWIDHCKASRKIGAYFGEQLGQTCVTNVWVPDGYKDIPVDRMAPRQRLKDSLDEIFVEELNPAHHLDAVESKVFGLGSEAYVVGSHEFYMGYGISNNKLICLDAGHFHPTEVISNKLSALALFTDGILLHVSRPMRWDSDHVVILDDELLDIGRELIRHDLLGTTHIGLDFFDASINRVAAWVIGTRNTIKALLRAMLEPVETLKKAELEGDYTTRLALSEEFKSYPFGAVWDYYCEKLGVPVREEWLAEVKKYEQDVLLKRSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ10</accession>
    <name>A0A398CJ10_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MgtE protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_11390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03286">
        <property type="protein sequence ID" value="RIE03286"/>
        <property type="gene ID" value="D3H35_11390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011002">
        <property type="entry name" value="FliG_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48029">
        <property type="entry name" value="SSF48029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="MgtE_N" evidence="3">
        <location>
            <begin position="148"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="316" mass="34494" checksum="FC85B58BA4ECEC72" modified="2018-12-05" version="1">MASADVEKNSYSGFERFLFFVTPVLFTAVLLGVLLLMFNKDWRESAMEIGNKIPVIKAIVPDPAEPEAAGATDEELTVSNARQKVDELKAQLTEQESSLTKATSESVTQKKTIEELNGKVEQLNKQIQEQTISTAQYDERIRSLAGMYGKMTPGKVAPILEAMTPEEAALVLGAMSETQRGRVLEKMSPQGAADVTQRIKDSKTVEDSQLQALQARVKQLEDEAKTLKTENKKLTEKAGLSAETLNADELNKTFSSMQAERAAKLLIAMAATNQSKALRILGVVDDSARSKILDAMSKEDSKLTSSLLGKLMPANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ85</accession>
    <name>A0A398CJ85_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_23165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01289">
        <property type="protein sequence ID" value="RIE01289"/>
        <property type="gene ID" value="D3H35_23165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="199"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="430" mass="48009" checksum="2F18276794ECF6EF" modified="2018-12-05" version="1">MKIRLSRQQWTAAALSVVCAGLGQLYGKRYAKGLLFLVVGQLVLWLWTPKLAQAIRGLVTLGDVPTMVVKGKTVLGDHSIFMMINGLIACFIAIAFALFYVYNVTDAAKAADARDRSEQKRASLRKRSAALPILLLLPALIFVLFVSAIPLLFNVLIAFTDYSAPLHIPDRSLVNWTGLRTFSTLFTEPAWYKTFFSIFAWNIVWAVLSTTTVFFGGMAVAMMINHRRVKWKKLWRTVFILPWAVPQFISLLVLRVMFNGSIGPINGLLENVGLSPVPWLSDSTMAKVTVLLANFWVSMPFTMALVAGILMSIPRDLYEAAEVDGAGGGAKFLWITLPHVLMAAAPIFIMQFAFNFNNFNLMYLLTDGGPANPNYYFAGSTDILLSWTYKMTLEQSQFNMASAVSIILFLVIAIMSIWNYSRTKSFKEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJD0</accession>
    <name>A0A398CJD0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1906 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02430">
        <property type="protein sequence ID" value="RIE02430"/>
        <property type="gene ID" value="D3H35_17145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015020">
        <property type="entry name" value="DUF1906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08924">
        <property type="entry name" value="DUF1906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="193" mass="20385" checksum="7437B87F40CFBD4F" modified="2018-12-05" version="1">MAKGIDCSVELNAKTAAALYAEGYRFAARYLVPKATKRLTGPEAASITAAGLQIVSVFETLAERSLGGAANGSIDGAEALQQAKLVGQPLGSAIYFAVDYDAQPQHFAAIEAYLRAAAAAIPGYIIGVYGSYAVVEEMAKRGASKHFWQTYAWSRGLKSNHANLYQYQNGATAAGLSVDLDEAIGNVGWWSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJF5</accession>
    <name>A0A398CJF5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2203 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03456">
        <property type="protein sequence ID" value="RIE03456"/>
        <property type="gene ID" value="D3H35_12415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018699">
        <property type="entry name" value="DUF2203"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09969">
        <property type="entry name" value="DUF2203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016498">
        <property type="entry name" value="UCP016498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="137" mass="15808" checksum="EFF81EEC30A051AD" modified="2018-12-05" version="1">MENRTFTLDEANALLPRLKEDLGNVQALMAELRTRYVKLQKRKALHKQMSIGTEEDPFFEEEGKLDFMRAEAELLLENFKRNGVLLKSIEPGLIDFPAVLDGKDVLICWMEGEESITHYHGWHDGFAGRKSLSDREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJP2</accession>
    <name>A0A398CJP2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_10830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03536">
        <property type="protein sequence ID" value="RIE03536"/>
        <property type="gene ID" value="D3H35_10830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017219137" evidence="1">
        <location>
            <begin position="33"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="489"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="548"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="676" mass="72827" checksum="8D563C8F668467EE" modified="2018-12-05" version="1">MKMKRTAACVLATALALGIPAASASYAGFAAAAESAAKTDSIDSQNASAFLDRFFEQEDVKRQASAIAVSIVKDGKVLAERGYGFTDDVSNAAVDPGLTTFRIASVSKVFTVFGLMQLVDQGKVSLQDNIEKYLGGYKVVNPFGKPVTVEMLLTHTTGFEVREPTNANFLLDPSQKPGTLEEAIFASFPPVVREPGTSYMYDNFASELAGYLVEKISGEPFNDYMTKHVFQPLGMTSTSYLQTEELLGRLPTAYDGGGSAVPVYRLTPSVIPEGSMITTAQDVSRFMLAFLNGGTAADGKSILSPSSVKAMSTFHVAINADVPDIAYGFEAPPLLYSNGRNVITKDGAIPGFSSFMWLLPEEKTGVFVTYNTNSGLSIELFREFMNRYYPGQTTFGDAGYKARPQSELKRFEGIYSDLRYGRLTSVRADADGTLSAGNSAGVFIKLKQSGELLFVDELGNPFAFKLDDQGNVDYLKYSNPGSYAAKLPKAAGFPDVPEDHPYAKYIHGLQAMGLLTADPAKPIGAENPVTREQFVHEIVREFGLPAATGSASFRDVAASPYGADIQAALELGLLNGTGNGYFRPERPIKREEAAVIVRRLLEISGVRIADSQTALAPGTSKWAETSVKALIDFKIHGPEVSFGNGQANYGSQKSLNVQELAAIMFLLQLPEVSLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJX5</accession>
    <name>A0A398CJX5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03003">
        <property type="protein sequence ID" value="RIE03003"/>
        <property type="gene ID" value="D3H35_20600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017352811" evidence="1">
        <location>
            <begin position="31"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="435" mass="46795" checksum="AF246323E43C3E55" modified="2018-12-05" version="1">MKLKKSGIVASTLVVALGLSACGQSNGNKAEPSADKPFAGQKLTVFALAHPWTDGMKASLGEFESATGIKVDLQVFPEEQLQQKLAVQFTSGAQTPDVFTYRPFMEKLLYDKNGWTEPLDGYVTKDAGYTFDDFSKASVDGSMVNGKLMSIPLWTDQFVMYYRKDLLEQNNIPVPKTLTEFEAAVKKLNDPSKDFYGFVSRGQRNALVSAAASFIYSEGGDFIVDGKAAINTPEAIRGLGMYANLLKNYGPKGALNMGWPQAAALFAQGKAAFYVDASALYNNTTDPEKSLVADKVGFAPFPAGSAGQKPYAIAAWALAMNPKSEKKDAAWAFMEWSTNKENVLRIQQSGVPGARDSVWASPNGIEKFPADLAAAIKTTMSIGVDHSVPQVMSVTEARDAVGSVVVKAMLGEDINAAAETANKELQAIIDSDNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK31</accession>
    <name>A0A398CK31_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_20990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_027088130.1">
        <property type="nucleotide sequence ID" value="NZ_QXJM01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03063">
        <property type="protein sequence ID" value="RIE03063"/>
        <property type="gene ID" value="D3H35_20990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="65" mass="7152" checksum="D0E8FA5C20B85438" modified="2018-12-05" version="1">MRGTVKWFNAEKGYGFISVEDGNDVFVHFSAIQGDGFKTLEEGQAVEFEITQGNRGPQASNVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK42</accession>
    <name>A0A398CK42_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-arginine kinase</fullName>
            <ecNumber evidence="5">2.7.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mcsB</name>
        <name evidence="9" type="ORF">D3H35_29960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the specific phosphorylation of arginine residues in proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + L-arginyl-[protein] = ADP + H(+) + N(omega)-phospho-L-arginyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43384"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10533"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83226"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.14.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Appears to be allosterically activated by the binding of pArg-containing polypeptides to the pArg-binding pocket localized in the C-terminal domain of McsB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6 7">Belongs to the ATP:guanido phosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.14.1" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00257">
        <property type="protein sequence ID" value="RIE00257"/>
        <property type="gene ID" value="D3H35_29960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004111">
        <property type="term" value="F:creatine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046314">
        <property type="term" value="P:phosphocreatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07930">
        <property type="entry name" value="bacterial_phosphagen_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00602">
        <property type="entry name" value="Prot_Arg_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023660">
        <property type="entry name" value="Arg_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000749">
        <property type="entry name" value="ATP-guanido_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022415">
        <property type="entry name" value="ATP-guanido_PTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022414">
        <property type="entry name" value="ATP-guanido_PTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547">
        <property type="entry name" value="PTHR11547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00217">
        <property type="entry name" value="ATP-gua_Ptrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00112">
        <property type="entry name" value="PHOSPHAGEN_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51510">
        <property type="entry name" value="PHOSPHAGEN_KINASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphagen kinase C-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RDXXRA motif of the pArg binding pocket involved in allosteric regulation" evidence="5">
        <location>
            <begin position="338"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <begin position="27"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <begin position="177"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <begin position="208"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE00257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="354" mass="39329" checksum="28D5FA6790249073" modified="2018-12-05" version="1">MAERSFVNDALSHWMKETGPESDVVLSSRVRIARNVRGIPFPLMAASEHSISVMEQLLGVAENGRLNGLGALEMIRLSELSELEKQVLVEKHLISPSLANESRNGAFILTRNEDVSIMINEEDHLRIQCLCPGFQIHQAWEWASKIDDVFEEQVDYAFDEKYGYLTSCPTNVGTGIRASVMMHLPALVLTGQINRILSAVQQVGLAVRGLYGEGSEATGNLFQVSNQITLGQSEQEIIENLHQVARQIIGHEKAARAKLLAESRPRIEDRVRRSYGILSHAAIMDSKESSQRLSDIRLGVHLGLLPDVKGETLNELLVSTQPGFLQQKFGEALEPEQRDMTRAQLIRSRLASGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK53</accession>
    <name>A0A398CK53_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2154 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_18645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02680">
        <property type="protein sequence ID" value="RIE02680"/>
        <property type="gene ID" value="D3H35_18645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024425">
        <property type="entry name" value="DUF2154"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09922">
        <property type="entry name" value="DUF2154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2154" evidence="2">
        <location>
            <begin position="128"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="240" mass="26816" checksum="15408B3A4821C973" modified="2018-12-05" version="1">MAVRLRRAGMAFLRQPMSDSEEMRPTMKFTNNALLFIAAGLYLAVGNLTGYSTVNAVLLLLIGIDRFRLDRSKLSILLIAVSTIALIISQFALFAVIILVSLGIYYFRTRPHVVGESSPGNNHKLFLNLRLDEQSWVLQSLSCWHAVGEVRMDMSRAVPEARETVLILQGLVGDLDLAVPEDYGLQIEASVLIGKIGRGSTKDGGVLQRVSWRSPDYDEREHQLKLQLFYLVGDIKIRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKE2</accession>
    <name>A0A398CKE2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_22570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01669">
        <property type="protein sequence ID" value="RIE01669"/>
        <property type="gene ID" value="D3H35_22570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="264" mass="29245" checksum="CFB2DF20930E5DAD" modified="2018-12-05" version="1">MNALETRDLSVCYGNQFVFQDLNLSIDKGKVTALIGSNGCGKSTLLRTMARLLKPQDGNVLLEGHSIATLPTKDVAKRMALLPQGPSAPEGLTVLQLVKQGRYPYQSWLQQWSKEDERHVSHALETTGLTELAERTVDSLSGGQRQRAWIAMVLAQGTDIVLLDEPTTYLDLTHQIEVLDLLYSLNVQEGRTIVMVLHDINLACRYAHHIVAIQDRKVFAEGSPEEVVTADMIESVFHMKSNVIKDPLYGTPMCVPHGKGRTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKW2</accession>
    <name>A0A398CKW2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3883 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01528">
        <property type="protein sequence ID" value="RIE01528"/>
        <property type="gene ID" value="D3H35_24560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024975">
        <property type="entry name" value="NOV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13020">
        <property type="entry name" value="DUF3883"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3883" evidence="1">
        <location>
            <begin position="198"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="333" mass="39443" checksum="F51AA04474C380B5" modified="2018-12-05" version="1">MSKSYLVEVSKWLYLFNNWSRDSEIPLSYSEAIYLRRKIKTDERLAPEKVLDELIEMDIIERRIDGRFEILTLSILAHKWIEEISGEGNFQLQKSHKHHIAKHYIKKWIIRPEIAGIFSLFVNEKNGQFFLEEHLFSDSLTFFKIKLLSFEVIYLKEGAYFLDSDFNFLIDGSRVNNVTTEKILLEQLELQHEIGLEGELWVVEYEKARIKKDHLGKGSQVERVSEQNVSLGYDVYSLVEPFEDERCIEVKTSRSPDISFYLTPNELTVAKMYGERYWIYLLVGKKKNMDPSKVYRIKNPARFFEDYDIKLHPSLYKVQLDVHQVSDYLDDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKY5</accession>
    <name>A0A398CKY5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03055">
        <property type="protein sequence ID" value="RIE03055"/>
        <property type="gene ID" value="D3H35_20950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="21"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="241" mass="25467" checksum="EE20F06780E6B07C" modified="2018-12-05" version="1">MKTTNLGEGVTQLSFFSSWFPINCCLVEEVDSVTLIDAAIPPLASGLLQAIRRTGKPLGHIVLTHAHNDHIGAVGALKSAFPEARIVISSRDARILAGDVSLEPHEAQTPIKGGIPKKPPFVQDVTFEEGARIGSLQAVATPGHTPGHFAFWHEASGTAIAGDAMSTRGGLSVAGRMRPSFPFPAWATWSAETSIASARKLLAMTPKALVVGHGPSLHKPAAAIIRAIEEAEAALTRRNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL14</accession>
    <name>A0A398CL14_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 16">Pyruvate kinase</fullName>
            <ecNumber evidence="6 16">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">pyk</name>
        <name evidence="20" type="ORF">D3H35_19880</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 16"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02882">
        <property type="protein sequence ID" value="RIE02882"/>
        <property type="gene ID" value="D3H35_19880"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 16" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 16 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0630">Potassium</keyword>
    <keyword evidence="15 20" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="17">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="19">
        <location>
            <begin position="356"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="18">
        <location>
            <begin position="503"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RIE02882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="584" mass="62572" checksum="01D5C87EFFF14C1B" modified="2018-12-05" version="1">MRKTKIVCTIGPSSESLENTKKLITAGMNVARLNFSHGDFEEHGNRIKTIRQACQELDKTVAILLDTKGPEIRLGKLKEEPIELVQGEYITLSTEEILGDKDRVPVTYKELPSDIHVGSTILIDDGLIGLTVVDIQGTEIKCQIVNSGPIKSKKGVNVPGVAISMPGLTEKDISDIKFGIEIGIDFIAASFVRRASDVLEIRELLERHDARHVQIISKIENQQGVDNLDEILEVSDGLMVARGDLGVEIPAEEVPLVQKQMIEKCNRAGKPVITATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGRYPTESVLTMARIAERAESALHYREIFQKQANAQQTSVTEAISQAVANSALDLDAKAIVTSTESGYTARMVSKYRPKSPIVAVTPNEQVKRRLQLVWGVIPVSGTPAVTTDEMFDIAVKGALDSGLVRLGDTIIITAGVPVGRSGTTNLIKIHHVGELLAQGQGIGSLSATGKVITARTPEEAVKKMTPGAVLVAPSTDKEYMPAFEKAAAVITECGGITCHAAVVGLNLGIPVIVGVSNALELLSDGKEVTLYAEHGVIYSGQAKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLE3</accession>
    <name>A0A398CLE3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Sulfite reductase subunit alpha</fullName>
            <ecNumber evidence="21">1.8.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">D3H35_12605</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="21"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03483">
        <property type="protein sequence ID" value="RIE03483"/>
        <property type="gene ID" value="D3H35_12605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02791">
        <property type="entry name" value="MopB_CT_Nitrate-R-NapA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041957">
        <property type="entry name" value="CT_Nitrate-R-NapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00932">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="14 17" id="KW-0408">Iron</keyword>
    <keyword evidence="15 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="16" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="13 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="20">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="18">
        <location>
            <begin position="857"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="1026"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RIE03483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1394" mass="153896" checksum="E0F24BF38AFE5722" modified="2018-12-05" version="1">MTKKVKSVCPYCGVGCGIVLEVSGNRVVKVTGDKEHPTNFGRLCTKGNTCAQAISESGRLEYALVRESRNNEPVKTGITDAIRGTAKRLKAILDEHGPDALSFYVSGQMSLESQYLVNKLAKGFIRTNNIESNSRLCMASAGSGYKLSLGADGPPGSYQDMDRTDLFFVIGANMADCHPILFLRVMDRVKAGAKLIVVDPRRNATADKASLFMQIKPGTDLALLNGLLHLIVKNGHTDPAFIEQFTSGWENMTAFLDDYPPDKVAQITGIPEADIRQTALWIGQSQEWMSCWTMGLNQSTHGTWHTNAICNLHLATGKICRPGSGPFSLTGQPNAMGGREMGYMGPGLPGQRSVLSEADRLFMEDLWKVPRGTLRTEVGTGTVSMFQSMQAGDIKACWIICTNPVATVPNRKNVIAALQAAELVITQDAFLDTETNRYADVLLPGALWSEGEGVMINSERNLTLMQKAVDPPGEALPDWRIIALIACEMGYSDAFTYETSADVYREIQQAWNPKTGYDIRGATYERLEATPMQWPCAPNGESDRNPIRYLNDGVSQSLKVDEDGSHPRLVFPTESGKGIFLARPYMPPAEMPDSEHPFVLNTGRLQHQWHTMTKTGKIPKLNKLNPGPFVEIHPEDAAILGIIDKDSVEVRSRRGLAILPAAVTDRVRPGNCFAPFHWNDVFGENLAINDVTNDAIDPISFQPEFKFCAVSIVRVAAPVNAEISNEGNLADGKIASMAVAAVQKEEMYMAQIDTLAKMLGIDSAPAMSLESHEKTYLSGFISSLRENESRSNPGVPVLPLTAPLEPTKRNWLDGVLAGLFSRTYLPDAAMPLLQSQSTAITSPAAASVAVIDRKPSVSIVWASQTGNAEAAAQKCAQSLQSSGYDIRIVDMSSYSVAQLAEERYVLFVASTFGAGDPPDNGADFWQTLQAENPPRLPGLRYAVLAFGDSNYDLFCGFGRNLDSRIEALGGKRLLNRNDCDTDYEDQVDSWIQAIEGAIHADDQAAQAGAHSASAANEAKIVDYDRNQPYRSRLLVNRLLSKDGSEKETRQFVFDLKNSGFRYEAGDALGIWPTNCPDLVKETIEALRVNPDDLIAVKGMGEVPVKDALLRHLDIIRITPAILQFVQERSKSEKLEHLLKSENNSELKKWLWGRQLADLLLEFPMTANARELIETLKPLQPRLYSISSSPKMNPDEVHITVSTIRYSFHGKARKGLCSAFLADRAENETPIPIFVQKSSHFRPPANPDDSMIMVGPGTGVGPFRGFLQERRATDAKGKNWLIFGEQRSDFDFYYKEELEGLQKEGFLHRLDTAFSRDQAEKNYVQHRMLQNGAELWAWLKDNAHFYVCGDASRMAKEVDATLKKIIQEHGKMSAADSESFVKEMIQSKRYSRDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLJ3</accession>
    <name>A0A398CLJ3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">argR</name>
        <name evidence="10" type="ORF">D3H35_26335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulates arginine biosynthesis genes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis [regulation].</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00717">
        <property type="protein sequence ID" value="RIE00717"/>
        <property type="gene ID" value="D3H35_26335"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034618">
        <property type="term" value="F:arginine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00173">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001669">
        <property type="entry name" value="Arg_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020899">
        <property type="entry name" value="Arg_repress_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036251">
        <property type="entry name" value="Arg_repress_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020900">
        <property type="entry name" value="Arg_repress_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34471">
        <property type="entry name" value="PTHR34471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01316">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02863">
        <property type="entry name" value="Arg_repressor_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01467">
        <property type="entry name" value="ARGREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55252">
        <property type="entry name" value="SSF55252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01529">
        <property type="entry name" value="argR_whole"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Arg_repressor" evidence="8">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Arg_repressor_C" evidence="9">
        <location>
            <begin position="79"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE00717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="149" mass="16525" checksum="67D5550BCC5A9A9B" modified="2018-12-05" version="1">MKGQRQRKIRELIGSKEIETQEELVEELGVGGFDVTQATVSRDIKELQLIKVPLEDGRYKYSLPQDQRFNPASKLKRALHDHFVSAEAAENLVVLKCLPGTAGTISALIDGMDWPEVVGTIGGDDTTLLVSRTKEQGQQVVGRIHDMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLL9</accession>
    <name>A0A398CLL9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03150">
        <property type="protein sequence ID" value="RIE03150"/>
        <property type="gene ID" value="D3H35_15995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="47"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="304" mass="32649" checksum="9F28D24A11C54441" modified="2018-12-05" version="1">MLIPTILLAGVMTGCGAMNASQDASEGKLVVEDFAGRKVAFDETPKRIVALGNGELDIVYALKGTLVGRPDDHGSLPNEAAREVPIVGSVHTVDLEKIAALRPDVVLGNHPINDNDIPKLERIGVKLVLTQANSIEDIRREILLLGKMLGKETLASETVDVMNRKLADIKGRPKGAQRALVVYGAPGTYLAALPNSLAGNLLETAGGYNVASDFPSLQNFPQYAQLNAERVIEANPDLILVMTHGDSEEVEKGFVREMESNPAWNSLAAVRNKRIHVLPSELFGTNPGTRAAEAVERLAELLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM03</accession>
    <name>A0A398CM03_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Acetolactate synthase</fullName>
            <ecNumber evidence="4 9">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ilvB</name>
        <name evidence="13" type="ORF">D3H35_10260</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="9">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 9"/>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03673">
        <property type="protein sequence ID" value="RIE03673"/>
        <property type="gene ID" value="D3H35_10260"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="12">
        <location>
            <begin position="25"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="10">
        <location>
            <begin position="214"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="11">
        <location>
            <begin position="406"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE03673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="581" mass="62827" checksum="03E34335DF3B1F7F" modified="2018-12-05" version="1">MSANSATLKSKEELIEKWGKPEVITGSEMLLRSLLLEGVDCVFGYPGGAVLYIYDAMYGFDDFNHLLTRHEQGAIHAADGYARSTGKVGVCIATSGPGATNLVTGIATAYMDSVPLVVITGNVATSLIGTDAFQEADIVGITMPITKHSYLIRDVEDLPRIIHEAFHIANTGRKGPVLIDVPKDISALKGLFQPSNDVSLRGYNPTVNPNKHQVDKMVRAIEEAERPIILAGGGVVYSGAHEELYEFITKTGIPTTTTLLGLGGFPSGHELHMGMPGMHGTWTANTTIQNADLLINIGARFDDRVTGKLAGFAPKAKIVHIDIDPAEIGKNVPTDIPIVGDVKAVLQQANAVAKYAGKADAWRAQIQEWKAEKPFKYLDSDAELKPQWVVSMIHETTKGEAIVTTDVGQHQMWAAQYYPFNKPRSWVTSGGLGTMGFGFPSAIGAQMGNPGRTVVSINGDGGMQMCAQELAICAINNIPVKVAILNNQVLGMVRQWQELIYDNRYSHIDLSGSPDFVKLAEAYGVKAFRASNKEEARSAWEQALAHPGPAVVEFVVRKHENVYPMVTQGSTIDQMIMGDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM25</accession>
    <name>A0A398CM25_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MinD/ParA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_11475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParA family. MinD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03302">
        <property type="protein sequence ID" value="RIE03302"/>
        <property type="gene ID" value="D3H35_11475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02038">
        <property type="entry name" value="FlhG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033875">
        <property type="entry name" value="FlhG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025501">
        <property type="entry name" value="MinD_FleN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003092">
        <property type="entry name" value="MinD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="4">
        <location>
            <begin position="26"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="287" mass="31697" checksum="70A8F43735217BD6" modified="2018-12-05" version="1">MHDQAQALRHLVHTRDIPKSTTTRILTVTSGKGGVGKSNFSLNFAMALQRRGYSVLVFDADIGLGNIDVLLGTPAKYNLIHLLKGEKTIWEIVQTGPGGLQFIAGGSGFQDLVRLSEDQLEYFAEQIGKLHGHVDYLLFDTGAGLSKETTRFITAAEEAFVVTTPEPTSITDAYALIKMMKTMGHDVPFRLVVNRVSDEREGRQTSDNFRQVADKYLGMDIPVLGYIPDDNHVSKAVKRQTALSLAFPDSAAAKGIDRIASAYLMEERDRAPAGMNGFLQRIRKLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMA9</accession>
    <name>A0A398CMA9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_16730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02359">
        <property type="protein sequence ID" value="RIE02359"/>
        <property type="gene ID" value="D3H35_16730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="315"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="386"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="674" mass="72728" checksum="C94979FA346C689D" modified="2018-12-05" version="1">MSASISKIGKALLQKRKSIGVQLFGIVFVSIILIVSVLGFNSYGKSKKIIRDKVSVASQQTLQQSTDKLDFLLSTYAGLTRQFMVDTSLRELLVAVSAKDISVPDKRAAQDKITDRMNSMISAEPNILTIRIIPKDLNINNALSTTGASALLIEGPSEAWLKKMMDAKGNVVFVPMMNKGLFGYSTEPSLTVGRLLKNLKNPEAEYLLLIELRSKLLSDAFANFKLGDTGQMMVVTEDNKIVYAASPELIDTTPPPLGKNMLVLNHTSETTGWKMIGSVPLNELERDSKTILSLTVWMIIAAAVAALLIGYVLIRIIGKPLEKLCVLMEKGENGDLSVRMDYRGQNEIARLSRNFNRMMEQIASIVGRTNESAQQLVRSAKELKAVSLETSSTAGDIASVTTQIAQGAASLAAEAERGIIQTETIGGKMRAATDTNGRLESTAGRVQAVSDQGSAYMRELIGKTEATEQLSRSLVERVSKLKESAGSIYTILNMMNEISKQTNILSLNASIEAARAGASGKSFAVVAEEIRRLAVQSKESIGVVHTITDVIQQEIDATVVDLGSVSPVLAQQNAAVLEAAEIFGGVKSEMNLFVQELAVSTESIIELDSSQKVLVESIGTVSAVSEESAASSEEVARMTTDQLAVSNKLVDLSNQLESLSERLIEQLDVFGGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN02</accession>
    <name>A0A398CN02_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03855">
        <property type="protein sequence ID" value="RIE03855"/>
        <property type="gene ID" value="D3H35_09910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="67" mass="7515" checksum="8BEEE1873B123ABB" modified="2018-12-05" version="1">MTKRAWLLNHYGVEKSAPRPVKSAKDKPPNFRAESLRTATKLIAGEAVVKIERNSSSRRSRHLATEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN38</accession>
    <name>A0A398CN38_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_18445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02659">
        <property type="protein sequence ID" value="RIE02659"/>
        <property type="gene ID" value="D3H35_18445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="120"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="360" mass="40602" checksum="099AA1EE77861436" modified="2018-12-05" version="1">MKIASPPRLLRRTAPLRDSGLVEFAAEDMDAYPILHDTVREFAGENTPADQTIYRYASYRELLGLLSRLQNRMRAEEANAIRCRFKQTDGKPGGSSSASSAEGSSESFSSEWEWLSGLFGSVGGRSVSDYILHRHFTTYLQPVVQPDGTIAGYECLLRPLPEQQPFRPAELFETARSIGQHSFLDREAREAAVNFSASHLPQGMKRFINFLPSSLISPDRCLNGTFETIRSSGTDPRDLVFEVVETERLDHPELSRIFNLCREQGVLLALDDVGDGYATLETVERLKPDYVKMDRQWVSGCDRDPVKQAYIKKLLDRASRYHGVVLAEGVEREEEWRYLREAGVPLYQGYLFGKAAPVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNC1</accession>
    <name>A0A398CNC1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VWA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_05170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04856">
        <property type="protein sequence ID" value="RIE04856"/>
        <property type="gene ID" value="D3H35_05170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="406"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="882"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="942" mass="102212" checksum="268100F0095C2245" modified="2018-12-05" version="1">MGLQFDHPWALTLLLPCTCFILWMLAKTPRLTGGRKIASIAVRSVILLLLVALVSGLTPYVRMEQRDVVFAADRSASLNSDDRMADWIGDAIASKENDDRAAVVSFGLNASVDRALSKEGEQSFSLRTNVNKSFSNAAGAIQLGAGLLERGGRIVLLSDGEENVGDLLRQGKRLKELGIAVDVVSVPKKQLNDASIDSLEVPASLKSGEKFSFEIKVTSSFAGQAELRLYEDETEKVRETVALERGENRFALESVAIDTGLHRYRAEIYAADDQRAENNTAFAFSRVDGPPRVLVIEGEPESSGNITASLQASLIPFDVIAPEQLPVELADYAKYDSLVLNNVPATRIAEAPMRNLGAAVSDYGIGLVMVGGKESYGLGGYFKTPVEKALPVYMDLKGKRQMPSLGLILVIDKSGSMADGKLELAKEAALRTVELMRDQDTVGVVAFDGSPWWVMEPTKLTERESVVSAIQGIQPNGGTEIYEAVNAALARMLDVDAQRKHIILLTDGQSSSNPGYSNLTSTMVDNDITMSTVAVGDGADTVLLERLANDAKGRFYFSNDQSTLPAIFSRETTLMSRTYIVENRFIPAIGQAGNWASSFSEGIPAVDAYVATTAKETAETVLLTPMGDPLLARWQYGSGRTVAWTSDLTGKWAKDWIGWSKLPDLFTQWLKWTFPQFSGSPYDVQADWTGGEAKLRIRETSSGSGGTANLSAIVTDEQGNRADITPIPVAPGEYTGSVPIAGPGVYLTQIGSGNGQNGSVAGFVVPYSPEYRLTDGGGADKLAKLADLTGGRVIDPSRPEDAFQGALTVRRNLHDVTRSLLVAAILLWIVDIAIRRISVPWRRFTTRIINIINYREKTKTKAAEPIAAISRLQQRKQRTGEFYAGNDPIRSEKAHIAEKPVVTKAQTPTSVDPSNSPISQPMPSSNSINRLLEAKKRSNRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNM4</accession>
    <name>A0A398CNM4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01517">
        <property type="protein sequence ID" value="RIE01517"/>
        <property type="gene ID" value="D3H35_24500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="172" mass="18739" checksum="22800CC0B99D381A" modified="2018-12-05" version="1">MQTENILHNLAPLHIAYKSKDAADPSELTLVKTSKFGKRMPFSQSILEYIGSPTEIQVSVNENGIAISQGLPDGGTSFVLRKAGKKPCVYSSQLVDTIAALFNLNFDGKTSISFYEVTYLNDGKVPVAFIPITQSSDTASEEQEPDFTEASAPEVEDSEDEELGRTRESLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNV5</accession>
    <name>A0A398CNV5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable malate:quinone oxidoreductase</fullName>
            <ecNumber evidence="4">1.1.5.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">MQO</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Malate dehydrogenase [quinone]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mqo</name>
        <name evidence="5" type="ORF">D3H35_20295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>(S)-malate + a quinone = a quinol + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:46012"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MQO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.4" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02949">
        <property type="protein sequence ID" value="RIE02949"/>
        <property type="gene ID" value="D3H35_20295"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052589">
        <property type="term" value="F:malate dehydrogenase (menaquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008924">
        <property type="term" value="F:malate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00212">
        <property type="entry name" value="MQO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006231">
        <property type="entry name" value="MQO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06039">
        <property type="entry name" value="Mqo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01320">
        <property type="entry name" value="mal_quin_oxido"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="512" mass="56168" checksum="BCA32E8EFE4C75D1" modified="2018-12-05" version="1">MSNEQTKTDVILIGAGIMSATLGSLLKELVPDWKITVFERRATAGEESSNEWNNAGTGHSSLCELNYTVEKPDGSIDISKAIKVNEEFQVSRQFWSYLVDSNVIRNPRDFIVPVPHMSFVKGEQDVTFLRKRYEALVDNPLFQGMEYSEDPEKLAEWIPLMMKDRTLDKPIAATRIESGTDVNFGALTRILFDQLKSKDVDIKFNHQVDDIKRTGDGSWELKVRDVDSGTAQRHTAKFVFIGGGGGSLHLLQKSGIPEGKGIGGFPVSGLFMVCQKPDVVAQHKAKVYGQAAVGAPPMSVPHLDTRVIDNKESLFFGPFAGFSPKFLKFGSMFDLITSVKPHNLVNMIAAGVKNVSLTTYLIKQVMLSKDQRMEELREFVPNANSEDWNLLVAGQRVQIIKETAAGKGTLQFGTEVISAADGSIAALLGASPGASTAVSVMLEVIKKCFPQHIKAWEPKIKEMIPSYGVSLLKNPELIRDNHTSTSRSLGLSESLPSTDSAPNGIINNEVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPD8</accession>
    <name>A0A398CPD8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ger(X)C family spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_01725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKC lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05266">
        <property type="protein sequence ID" value="RIE05266"/>
        <property type="gene ID" value="D3H35_01725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008844">
        <property type="entry name" value="Spore_GerAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038501">
        <property type="entry name" value="Spore_GerAC_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35789">
        <property type="entry name" value="PTHR35789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05504">
        <property type="entry name" value="Spore_GerAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02887">
        <property type="entry name" value="spore_ger_x_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="366" mass="41399" checksum="48D900F310B23637" modified="2018-12-05" version="1">MTRFVAAALLIAICLCLGGCWDQRELKNIRMVHTAGVDLIDDESIRLTVSIPTVKASIESQGTVVTPKVSGEGHSVQEASMNLQEVVSQHMDLRETRILLVNRKLAEKNLYEGLDFFYREAHYPINVYIAVTDPSAQKIVQLEVEDRSLISEYLYDLLVSGEEEGLIPKESPYLITPIMFTAGIDNVLPFLIEANVKNRAKINGVALFHEAKMTGKLDDIHARTYVLLTNKKTYGTMTEKIGPKNTYVTLTFDTASHRYKLNTEGRIKADIYVKINGELIDNPSGIRIDKSEINLLERKLEDILTKRAEETISQLQQAKCDGLGIGQRIKATHNRLWRKLDWGKEYPQIKMVPHIEIKIENHGLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPI9</accession>
    <name>A0A398CPI9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_06730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04302">
        <property type="protein sequence ID" value="RIE04302"/>
        <property type="gene ID" value="D3H35_06730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13477">
        <property type="entry name" value="Glyco_trans_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="184"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="366" mass="42229" checksum="9FCE816425F3259A" modified="2018-12-05" version="1">MKKVLVLANHEFALYNFRKEVIENIVANQYEVYLSLPYGEKVEYFKEMGCTFIDTFIDRRGANPFADMKLLLSYLRIMKQIRPDIVLTYTSKPTIYGGIICSLLKIPYIVNNSGLIILPEKLSIIKPIISLLYKLGVKRSNCIFYQNEVEQSTLNKILNRKDRYRLIPGSGVNLVDHKQCDYPSEENGLVFNYVARVMKGKGIEEYLECAKTIKGKYSNVTFNIIGFFDDESYKSIVEEYHNQGIVCYLGAKKDIRPYIEKAHAIIHTSYSEGMSNVMLEHCAMSRPCIASNIPGCKEIVDDGKNGYLFEVKNVVELTQKVEKFIKLSHKEKEKMAKSAREKVEKEFDRRNIVSSYMEEINKICEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPM5</accession>
    <name>A0A398CPM5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="4 8">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_07015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="4 8"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04493">
        <property type="protein sequence ID" value="RIE04493"/>
        <property type="gene ID" value="D3H35_07015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="4 8" id="KW-0521">NADP</keyword>
    <keyword evidence="4 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 8" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="9">
        <location>
            <begin position="179"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="33"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="75"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="471" mass="51754" checksum="3D3A088F61ABC18B" modified="2018-12-05" version="1">MSKANIGVVGLAVMGRNLALNIESRGFNVAVYNRSREKTDDLLNTDGKGKNLVPTYSVEEFVASLEVPRKILIMVQAGAGTDATIESLVPHLDKGDIIIDGGNAYFPDTQRRSKQLTEQGFNFIGTGVSGGEEGALKGPSIMPGGPEEAYRLVEPILTGISAKVNGDPCCTYIGPDGAGHYVKMVHNGIEYGDMQLICEAYQLLKDVLGVSTDELHSIFAEWNKGELDSYLIEITTDIFAAKDPETGKPMVDVILDSAGQKGTGKWTSQSSLDLGVPLSIITESVFSRFLSAMKEERVAASKVLKGPQTAPFEGDKAAFIESVRKALFASKICSYAQGFAQMRAASEEYGWNLRYGDIAMIFRGGCIIRARFLQNIKDAYDREPELRNLLLDEYFKGIVESYQGAWREVIATAVRYGIPVPSFASAIAYYDSYRSERLPANLLQAQRDYFGAHTFKRLDKEGVFHHNWLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPM7</accession>
    <name>A0A398CPM7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lasso peptide biosynthesis PqqD family chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05366">
        <property type="protein sequence ID" value="RIE05366"/>
        <property type="gene ID" value="D3H35_00850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="97" mass="10691" checksum="34B796C346316D3E" modified="2018-12-05" version="1">MNIIGNDHAQTVVQAEGSIVSDMNGEMIMFSTRTGKYYNLGSVGGRIWELIAAPVAVGRLVDELTAEFEVERGECARQVGEFLRCMHLESLIEVRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPS0</accession>
    <name>A0A398CPS0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04543">
        <property type="protein sequence ID" value="RIE04543"/>
        <property type="gene ID" value="D3H35_05470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="109" mass="12216" checksum="F2E96AF5678576DD" modified="2018-12-05" version="1">MKHDIQQFKADFFKALAHPMRIRILEALSEGDKNVNELQSIVGSEGSAVSQQLAVLRNKNVVYGIKDGTSVIYSLRDPLIKELLTVAKQIFDNHLVDAISLLETIRNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPZ9</accession>
    <name>A0A398CPZ9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_03785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="2">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04623">
        <property type="protein sequence ID" value="RIE04623"/>
        <property type="gene ID" value="D3H35_03785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="3">
        <location>
            <begin position="34"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="195" mass="21388" checksum="65691406D84157AD" modified="2018-12-05" version="1">MLYRFSRAIVRIVYTLFFRLEARGVENIPKNGPVILCCNHKSLQDPFTLGAWVPRKVHYMAKEELFRVPVVGTVIRAWGAFPVKRGGVSKEAIRTAIDLLKEGHVMGIFPEGTRNKTLGAGKKGAVTMAIRSGAAVVPVALVGEYKLFRRVIAVYGAPIDMKPFADAGTSESAEQATATIMERIGEMLQTQRPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ53</accession>
    <name>A0A398CQ53_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">L-lactate dehydrogenase</fullName>
            <shortName evidence="6">L-LDH</shortName>
            <ecNumber evidence="4 6">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ldh</name>
        <name evidence="12" type="ORF">D3H35_12245</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of lactate to pyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(S)-lactate + NAD(+) = H(+) + NADH + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Allosterically activated by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="4 6"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03429">
        <property type="protein sequence ID" value="RIE03429"/>
        <property type="gene ID" value="D3H35_12245"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00488">
        <property type="entry name" value="Lactate_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011304">
        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01771">
        <property type="entry name" value="L-LDH-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="10">
        <location>
            <begin position="5"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="11">
        <location>
            <begin position="145"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="120"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="148"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6 7">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="79"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine" evidence="6">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE03429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="305" mass="33147" checksum="8F9BE5D5DAD4A1A7" modified="2018-12-05" version="1">MKKTRIVVIGVGAVGSTTAYTLLLRERADELVLIDANKEKAAGDALDMNHGLPFLGRTKVWAGTYEDCRDADIVVVTAGAAQKPGESRIDLLKRNVGIFDSIIGEVTKYNSNGILLIATNPVDVMSYFSWKKSNWPASRVIGSGTVLDSARFRYLIGEQLGIDARSVHAQIVGEHGDSELPLWSLANVAGTELNFDEEEKASIFTNTRDAAYQIIEAKGATYYAIGLALDRICTAILKDEGAVLNVSTLLEGQQGLSDVYLGVPCIVDRQGVRRTMDIELSDKELEQLRQSSAKLKGLIASLELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQH9</accession>
    <name>A0A398CQH9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03519">
        <property type="protein sequence ID" value="RIE03519"/>
        <property type="gene ID" value="D3H35_12075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="3"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="251" mass="28212" checksum="432E127A07CF2899" modified="2018-12-05" version="1">MIGLVHGMGEHMGRYGHVGEMFAQTGYVVFGFDQRGHGRTEGKRGHTPSYEALLEGIDWMLTQMRSRYPGVPVFLYGHSMGGNLTLNYVLRKQPELAGAIVSGPWLKLAFAPPSLSLIVGRLVENVFPSYMNDRPISTDRLTSDPDMAAMIRGDRLGHGQITAKYFFSIHRSGLWALNHASELRIPLLLMHGGDDSVTSIEASRKFADHAGPRCMFVEWPGFKHELHNEKDREAVFAFIRRWLEERTSTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQN8</accession>
    <name>A0A398CQN8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02137">
        <property type="protein sequence ID" value="RIE02137"/>
        <property type="gene ID" value="D3H35_15385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="186" mass="20168" checksum="5A9E2B8CEF0FEA4E" modified="2018-12-05" version="1">MDIGSAIRAIRKRKNITIAQICEATGLSQGFMSQVETNKTSPSIATLDNIAAALNVPLTYLLMKKENRMSVVRKEERKATTSGSEKLKVEHLSGTKNMRLMLVELPPGASTGDAPHAHKGQESHMVIRGEIVAEQGEDSAVLEEGDSFSWDACIPHSVKNLSDGVSVVLIAVYTESESELEPDFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQZ5</accession>
    <name>A0A398CQZ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03689">
        <property type="protein sequence ID" value="RIE03689"/>
        <property type="gene ID" value="D3H35_10345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="61" mass="6910" checksum="97AC2A2278FCD131" modified="2018-12-05" version="1">MNGLRIPQGDDTVKVELTIKELMALAGIKFHGNHKVEVSAKKKLHNAIDDQYQIEENRPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR25</accession>
    <name>A0A398CR25_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03719">
        <property type="protein sequence ID" value="RIE03719"/>
        <property type="gene ID" value="D3H35_10515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="49"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="251" mass="28919" checksum="94E7EC0DF7CC6231" modified="2018-12-05" version="1">MSYKGYQFYDDDQNFQKYLERRNWAENANDTIEKPIFLELLSDVKGHSILDLGCGTAAFGLDLLDLGAYSYTGVEGSANMVEESKKIMNRTNGKVVHTSMEDWNSPEASYQLIISRLAIHYLPEIDEVFSKVHRSLAHGGSFIFSVEHPVMTSSFGIARPEGMKQDWVVDNYFHSGIREQEWLGGKAIKYHRTIEDYFHALRKAGFAIESLRESKPRAEQFHNAETYERRMRIPLFLFFKGTKPVSTNKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR45</accession>
    <name>A0A398CR45_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="4 6">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nadE</name>
        <name evidence="9" type="ORF">D3H35_16370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="4 6"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02297">
        <property type="protein sequence ID" value="RIE02297"/>
        <property type="gene ID" value="D3H35_16370"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00193">
        <property type="entry name" value="NadE_ammonia_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022926">
        <property type="entry name" value="NH(3)-dep_NAD(+)_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="261"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="269" mass="29480" checksum="B0D0B1516251D5EA" modified="2018-12-05" version="1">MSLQQDIIAKLGVKPTIDEDEEIARRVAFLKDYVKQAGASGLLIAISGGIDSAVAAGLCKRATDELSAETGKEYLTLGVFQPYGEQEDIDHSYAVAEAFNIDRKVETNIEDAVSEIVLETEYGFKALGIHRHISRGGKGNVKARTRMVVQYALAFDLNLLVVGTDHASEALTGFFTKWGDGAVDITPLSTLNKRQIRQIARRLGVPSEIVDKAPTAGLWEGQTDESELGVSYDDNSDYLEGKEIAAQARETLEKHYLRTEHKRNTIPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR56</accession>
    <name>A0A398CR56_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent protease ATPase subunit HslU</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Unfoldase HslU</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">hslU</name>
        <name evidence="8" type="ORF">D3H35_11340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ClpX chaperone family. HslU subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03278">
        <property type="protein sequence ID" value="RIE03278"/>
        <property type="gene ID" value="D3H35_11340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036402">
        <property type="term" value="F:proteasome-activating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00249">
        <property type="entry name" value="HslU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004491">
        <property type="entry name" value="HslU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF3">
        <property type="entry name" value="PTHR48102:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00390">
        <property type="entry name" value="hslU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="50"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="ClpB_D2-small" evidence="7">
        <location>
            <begin position="355"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="61"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="463" mass="51969" checksum="13B14E69A873FDBD" modified="2018-12-05" version="1">MNEQLTPRQIVAELDKYIVGQKPAKRSVAVALRNRFRRSRLPEEIRDEIVPKNILMIGPTGVGKTEIARRLAKLVQAPFIKVEATKFTEVGYVGRDVESMVRDLVETAIRMVKEERTEKVKDKAEKAANERLVALLVPSPAKAKTQRNPLEMLFGGVQNQDEPEAAVDPSIEGKRRDTREKLEAGALENETIEIDVEDATPSMMDMFSGPGQEQMGQNMQEMLGQFLPKKRKKRRLSVKEARKVLTQEEATKLIDMDDVITESVRRAEQSGIIFIDEIDKIASGGSRQGPDVSREGVQRDILPIVEGSTVMTKYGPVKTDYVLFVAAGAFHIAKPSDLIPELQGRFPIRVELSSLTDEDFVRILTEPQNALTKQYTALLQTEGIEVDFTDGAIAEIARMAQEVNRNTENIGARRLHTLLEKLLEDLSFEAPELQLESMSITPEYVREKLATIASNRDLSQYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR94</accession>
    <name>A0A398CR94_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_14360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01951">
        <property type="protein sequence ID" value="RIE01951"/>
        <property type="gene ID" value="D3H35_14360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027132">
        <property type="entry name" value="SMC6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="PTHR19306:SF6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="76"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="292" mass="32411" checksum="8DDA0F2D57687F7C" modified="2018-12-05" version="1">MFRYPRKLPPIKRFHDFYSIFQSILRFIDEAEAICYDKCNSRKHRSNLFLTGRGGRNVDEKLDLILEIVIGLRSDVETLKADMVEVKGDIAELKADVAELKADVAELKTDVATLKADMAEVKADVAELKADVAELKADVAELKADVAELKADVAELKVDVAELKADVAELQTDVATLKADMVGVKANLSALNADVSVLKTEMAGVKFEISGIKVEISGIKSEMDDMKTTIARLDVRMERMSLTLEKTFETAGQSKESITYLHEGHGRHELLLDEIAKSLLEQSARHRLAHPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRH8</accession>
    <name>A0A398CRH8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_03090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05143">
        <property type="protein sequence ID" value="RIE05143"/>
        <property type="gene ID" value="D3H35_03090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="73" mass="9011" checksum="26814CFE5A9B9FD7" modified="2018-12-05" version="1">MIKAIEIDYLFRCIVIKQGEEFKRCTNVLFHQEYYSSVDEEDYEYYLGFTNKDFFFVNSLDEVKERFEIRLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRT3</accession>
    <name>A0A398CRT3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Efflux RND transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000012">
        <property type="protein sequence ID" value="RIE05305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05305">
        <property type="protein sequence ID" value="RIE05305"/>
        <property type="gene ID" value="D3H35_01270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="155" mass="16882" checksum="AD89B0332C1E778D" modified="2018-12-05" version="1">MERSRVVKEELPTKFFHKDGKSYVRVAATVEPSQLSIVGADIKKAMNDVKTPDGVKLNVGGASADQSEDFMSLFMMMLVSIGIVYLIMVITFKTLKAPLAILSSLLFVPIGAVLGLLIGNVKPDFTAIFGVVMLVGIVVTNAIVLIDRLDRTKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS26</accession>
    <name>A0A398CS26_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_00750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05353">
        <property type="protein sequence ID" value="RIE05353"/>
        <property type="gene ID" value="D3H35_00750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="5">
        <location>
            <begin position="135"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="216" mass="23655" checksum="A4AF70080590A28F" modified="2018-12-05" version="1">MKIVIVDDHPLVRKGLSAVLAKEDGIELAGEAETIQEALALIETTKPDLVIVDIRLGGESGYDLVRTIRHLPCYFMMLTSSASEADIRKAEESGADGYVLKDAPPEELLLAVRMIGRGRKYFDQSFLDTLLRKEADDPLEKLTPKEKEVLSALGEGLSNGALAKKLVISEFTVKKHVSRIFQKLNLNDRTQAALFAQAQGMGDYSPPDKRADGSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS47</accession>
    <name>A0A398CS47_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000006">
        <property type="protein sequence ID" value="RIE05425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05425">
        <property type="protein sequence ID" value="RIE05425"/>
        <property type="gene ID" value="D3H35_00625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="144" mass="15569" checksum="78BE9125CA78003E" modified="2018-12-05" version="1">MAGVALQSGGKKRKGGSGSERLRSIRTRSRRTRRRKAAISAAAGSNGSDPDVNSVSGPRVKRKKGTDMWGLPISGTLSRATDDGEGGIIGEPRKKKGPGGRRRQGNRAGGGRVPPTQERELRNPLLRLRFRRNGSTETQKEKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS74</accession>
    <name>A0A398CS74_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10690</name>
        <name evidence="1" type="ORF">D3H35_12665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000035">
        <property type="protein sequence ID" value="RIE03598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03494">
        <property type="protein sequence ID" value="RIE03494"/>
        <property type="gene ID" value="D3H35_12665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03598">
        <property type="protein sequence ID" value="RIE03598"/>
        <property type="gene ID" value="D3H35_10690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="76" mass="8447" checksum="4EB6AB020C0BFFA5" modified="2018-12-05" version="1">MLEEIRDEIKRSEHLRESPRLAPVPLIDGTVKLMLFDKQTGDAPSPAGPKISFALSFSHNAKPACMETISRHSRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSK9</accession>
    <name>A0A398CSK9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02361">
        <property type="protein sequence ID" value="RIE02361"/>
        <property type="gene ID" value="D3H35_16740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="209"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="315" mass="36910" checksum="E9146E71076745D4" modified="2018-12-05" version="1">MELQTVGRIHHEGYRHSIWYNDNENLNWNDDHHSRYKLVLVLEGSGLVEHASSTYPIIAQSIFCLNESEQLRLTSGSGLIMKSLYFHPHVVNSKFTLHDSDAQNRLERDDLSTSDIHDVWCLGPFFDRQEPFYGCTPIDSAVARHAFKIMESINGQLTDQPDFHWPCRSRSYLLELLFLVSRIYREAESFPDRIPPVLSSKPDSSEQLESIVRYVHTHYREKLKIDDICKKFHTNKTTLNNQFKQYAGISVMGYLNQIRMQMASSMLRNTLLPKHEIMEMVGIHDSAHFLRNFRKFAGYSPSEYRKSFCWMLQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSP0</accession>
    <name>A0A398CSP0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipopolysaccharide biosynthesis protein RfbH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfbH</name>
        <name evidence="2" type="ORF">D3H35_19535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02827">
        <property type="protein sequence ID" value="RIE02827"/>
        <property type="gene ID" value="D3H35_19535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="441" mass="48777" checksum="C5DAAE3761E314B6" modified="2018-12-05" version="1">MALSRDEWRQTVLESAAHYYDSAEKPQPFRPGLDPVPVSGKVFDAEELQLLVDASLDFWLTTGRYAAQFEKQFANAMGTRYALLTNSGSSANLLALSALTSPQWGERRLKPRDEVITAAAGFPTTVAPIVQNGCVPVFLDSHIPTYNLDASMLEKAVSERTKAIVVAHTLGNPFDLREVKRVADKYGLWLIEDCCDAVGAEYDGRKVGTFGDVATASFYPAHHITMGEGGAVLTSDPRMKKIVESFRDWGRDCWCDPGKDNTCGKRYGWQLGELPCGYDHKYTYSHIGYNLKVTDMQAAVGVAQLKKLPGFIQRRKDNFAFLREALAPLEDVLVLPEATPDSVPSWFGFPITVREISPISRNELVQFLEARKIGTRLLFAGNLLKQPAFRDISCRVVGGLPNADRIMNGTFWIGVYPGLTDEMLAFAASSLFEAFGRSVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSX0</accession>
    <name>A0A398CSX0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_01695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05260">
        <property type="protein sequence ID" value="RIE05260"/>
        <property type="gene ID" value="D3H35_01695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="13"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="7">
        <location>
            <begin position="136"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="136"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE05260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="237" mass="27163" checksum="ADE1ABF91617246C" modified="2018-12-05" version="1">MPKKERFSLMKFKILVVEDETDIRRLIRLILENEGYRVLTAENAEEGIRLFDRDRPDFVILDVLLPGMDGLQLCAEMRRSSNVPVLFLSCRRDAEDIVAGHDCGGDDYMTKPFDPAVLAAKVRAGLRRVPVRMPKRDILRVGRLQADFGSREIFLDGEPIPLFAKELQLLFFLMKHAGQVFSAVQLYEQIWGMGGDSEDQTVKVHISTLRKKLDDDPVRSNYIQTVRGFGYKFVRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSY3</accession>
    <name>A0A398CSY3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02431">
        <property type="protein sequence ID" value="RIE02431"/>
        <property type="gene ID" value="D3H35_17150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="430" mass="46394" checksum="57622E67A1C30A48" modified="2018-12-05" version="1">MADAVISLTDQQLGAQLTLTPFLPTNVWLEGPYDLLFTKLLVTLAAPALQNAPVSAHLNVSVGSDIPLQSFTLGGGAAVTLLCDDLSVFANRAWEASPINIADESRRTALRLVYRPDPPIKVHDDTYKVENLPSLTVNVALDGQWMRTPCTFVYPVRLDGVHNDRTFTLKWPWAGDSGAADLDLTMTGQIAGRSPTGSVKTAHASDVTVSETFQIGQTIPLTNPDGKPAGACSLAAIWLRFSKLPQSKLRLCLQITTVDEQRQTPVERPYLRFVTNLSSLPDDYIATEDGFWFRAELAAPLALDADAASRPLAITALGYGDHVPLSQGPASGPWKQPALSRDFTGVLGWKQNKDGFQWAVDAEIVYRPGEPSSFAVTVGDSAITLAVAGPNVSAGVATPIPVNGDRIVTVSSAWRGDYTYTLTLNRSFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT15</accession>
    <name>A0A398CT15_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetylornithine aminotransferase</fullName>
            <shortName evidence="2">ACOAT</shortName>
            <ecNumber evidence="2">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">argD</name>
        <name evidence="4" type="ORF">D3H35_15200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:18049"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.6.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="2">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02104">
        <property type="protein sequence ID" value="RIE02104"/>
        <property type="gene ID" value="D3H35_15200"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="97"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="215"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="394" mass="42400" checksum="2D271E163556C1E2" modified="2018-12-05" version="1">MSDSALFPTYARFPITLVKGKGSRLWDDQGKEYLDFASGLAVTNLGHVPDAVKNALVKQLDELWHMSNLFSNPNQEKAARLLADNSCADTVFFCNSGAEANEAAIKLARRYHQKVRGEERYEVITFTQSFHGRTLATLTATGQDKVKEGFLPLPAGFVHVPLHDLKALEAAVNDRTAAVMLELVQAEGGVIPVDPDFLREVRKLCDKHGLLLILDEIQTGMGRTGKLFAHQHYDVEPDVFTLAKGIASGFPVGAMLAKEKFVPAFTAGSHATTFGGTPIAMAAVIATIETMLKENAPQKAAEAGDYLTAQLRASLQDVPGVIEVRGKGLLIGILCDAPVSEQIGELHRRGLLVVPAGPNVIRLLPNLLVTHEEIDAAVSLIAAVLTEKAAAKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT18</accession>
    <name>A0A398CT18_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_20405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02967">
        <property type="protein sequence ID" value="RIE02967"/>
        <property type="gene ID" value="D3H35_20405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="7"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="379" mass="41084" checksum="53053E146CA0FFFA" modified="2018-12-05" version="1">MIATILDTIGHTPLIRIPNTNKANEGQVLLKYERYNPGGSIKDRAAIYIVEEAERRGLLKPGGAIIESSSGNFGISLAMIGAAKGYRVIILVDPKTTSANLALLKGFGAEVIVVTEQDDSGSYHKTRISLANKLAREIENSYRPDQCFNLLNSEAHYNSTAREIVDSCSNKIAAFVTAVSTGGQLGGISKYLKRVAPNVQIIGVDAVGSAIFGGRSDSYRIPGIGLSWTPLNLNMEYVDCAYKITDEQAFLAARAFARHEGILMGPSSGACALVALKMAQELAPDQCIVCMVSDGGERYIPTLFNDEWMEEQGFAAAADIASIRAMARQLQPWSTHPADSVNERLDLIQSLEVPDSTLRMNEEVLAREHSNSERSITID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTC4</accession>
    <name>A0A398CTC4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_08670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04018">
        <property type="protein sequence ID" value="RIE04018"/>
        <property type="gene ID" value="D3H35_08670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="303" mass="34738" checksum="85AC3C7892D448CD" modified="2018-12-05" version="1">MSVNIENIEAFVYVIHYGSFNKAAEALYLSQPSVTARIQTLERELNCRLFDRQGKQIQITEEGKRFLPYAQQLLLTFQKGKLHVNQKKSHPEEFRIGCTISVSNYIIPELLPRLKRRFPNTQYKIVTGVTDDIVGKVVNKEVDIGFVRNVNHPHLQSVKFYEDPIRLYTYKDHPFLHGERPTVEAIAAQPLVFFECGALDWLRIHRIFENLDQPPNIQIQTDNSEMAKKLVIQKTGICFLPGVCVQQEIREEKLFSIPLAETEGISMQTNVVSCHGEHAPFIETILEFGKELFANTPVLSNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTF5</accession>
    <name>A0A398CTF5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glycyl-tRNA synthetase</fullName>
            <shortName evidence="8">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glyQS</name>
        <name evidence="10" type="ORF">D3H35_12955</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of glycine to tRNA(Gly).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03117">
        <property type="protein sequence ID" value="RIE03117"/>
        <property type="gene ID" value="D3H35_12955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00253_B">
        <property type="entry name" value="Gly_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022961">
        <property type="entry name" value="Gly_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="2"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="215"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="324"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="200"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="210"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="284"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="328"/>
            <end position="331"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="456" mass="53008" checksum="8576B251DCD81FBD" modified="2018-12-05" version="1">MEQIVALAKHRGFIFPGSEIYGGLANTWDYGPLGVELKNNIKRAWWKKFIQESPFNVGLDAAILMNPRTWMASGHIGNFNDPMIDCKHCKARHRADKIIENALDAKGIEQIVDGLSFDQMKALITEHQIACPDCGSRDFTDIRQFNLMFKTFQGVTESSTNEIYMRPETAQGIFVNFKNVQRTMRKKLPFGIGQIGKSFRNEITPGNFTFRTREFEQMELEFFCKPGEDRKWFEYWRGFCREWLVKLGMKENHIRLRDHSEDELSHYSNATTDIEYRFPFGWGELWGIADRTDYDLKQHMDHSGEDFSFNDQESNERYIPYCIEPSLGADRVTLAFLIDAYEEQQLDDDDSRTVLRLHPALAPIKAAIFPLSKKLAEGAQHVYAELISDFMVDYDDTGSIGKRYRRHDEIGTPYCITYDFESESDGQVTVRDRDSMTQVRMPIADLKTFLLERIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTH4</accession>
    <name>A0A398CTH4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D3H35_18180</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02611">
        <property type="protein sequence ID" value="RIE02611"/>
        <property type="gene ID" value="D3H35_18180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024478">
        <property type="entry name" value="HlyB_4HB_MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12729">
        <property type="entry name" value="4HB_MCP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="207"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="551"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="829"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="951"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="1098"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="437"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="878"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE02611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1217" mass="136395" checksum="FEC261382F53573C" modified="2018-12-05" version="1">MKIRSKLIGGFSLLLLIMVINTSLSYGRLSKMNESMNDFYENRFLKVVLVLNARGEVNSAGRSINDFLLGNVDNPEQATDNIQTRISNVSEQIQKFAKLNISPSEQQILDELNFNKGRYEEFLQRFIEFAENGRVDDAKALLLSQGRSFQDAFINSLNSVVTFEQKSLEADIASSKQAYTDSVRLTAASTAFGILLGGLIIWLVIPSITRGLNQLGKMAERFGRGRLKSFSRMEVRSKDELGDLAGIFKRIALELHAKNELEARFNEAQKRQAAMDGQLARVPELLRQTSEPDKIAQSFVAEFAPYLGASYAAVYLTDALGAGEKLTLAGAYAALDDGENPLKPTASFRRGEGLVGQCAMGYSPLKLDDVPEDYVKISSGLGSARPRQLALYPIRFDEEVIGVLELASLAPIPAENDELAAALCEKFATIMNHIRSRQRVEELLRESQTQSEELQAQSEELIAQQEELRQTNDKLEAQKSILKRSEDRLRQQQEELEHTNQELTLKTMSLEEHVKRTDMQNRQIAKANSELERQALQLALSSKYKSEFLANMSHELRTPLNSLLILSEFLTENEERNLTDKQQEYMRTIHSSGSELLKMIDEILDLSKVDAGKMDIHPEWMAIGDITASIEHMYAPMALRKGLGFGISVADELPDSFRTDGHRLNQILRNLLSNAMKFTETGSVEVTVTRPSEDQLRSPDRIEGMSYLAFTVTDTGIGIAPENRESVFEAFRQADGTTNRKYGGTGLGLTISRELARLLGGWIGLCTEPGKGSSFTLVLPETFSEVKVDKALSPILELERGQEQTAAAAAPAAPEVEDDRDTISKGDKVLLIIEDDVSFARVLLEMARSRGYKGIIALRGDEGIEAARTFIPDAIILDIQLPVADGWTVLYALKDNAETRHIPVHVVSVAEQSPHGMRMGAIDHLQKPVNREQLEEVFANFSAVLDNKPKHLLLVEGNDVERASLSELIGYDDVAVTGVADAETAWGLLETGQFDCVVISADLSDRGVTRLLDRIRKKPSMRRLPVILHGADSQRDEETVRRFHRYSDTILLKDVKSPERLLEETTLFLHRVEEDLPEEKRELLRKLHRKEEAFEHKKILLVDDDVRNVFALSSVLEHRQMEVVVAENGREAIEKLKENADVDLILMDIMMPEMDGYEAMRKIRENPQWSKLPIIALTAKAMKDDRGKCIEAGASDYIAKPVHTDQLLSLMRVWLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTP8</accession>
    <name>A0A398CTP8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_12745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000038">
        <property type="protein sequence ID" value="RIE03237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03237">
        <property type="protein sequence ID" value="RIE03237"/>
        <property type="gene ID" value="D3H35_12745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="31"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="170"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="419" mass="46295" checksum="3BB541AE06F38BD7" modified="2018-12-05" version="1">MKASPSAGYFVRYRYARRGGDSRAGASIRPCNVFQRCGNDLSTQAVGPKILWIKKHEPEVYAQTARFLTATSYLVYRLTGKFKVDHYTAGAGFTPFYDCQQHAWYPEFCKDIVEIDQLPEIGWTTDIAGVITDEAAQLTGLSRGTPVIIGTSDAAAEAVSVGVVKPGQMMLMYGSTAFFIEVTNEPIQDSRLWSAPYLFPDTYALLGGMSTTGAITRWMRDQFAVDLVKAEQYSGKHAFESLMGEAVHIPPGSEGMVTLPYFSGERTPIQDPMASGVVFGLTLAHTRGHLFRSILEGVGYGINHHLEVMKEIGAMPSELVAVGGGTKNELWLQIVSDIAAEVQKVPKVTIGASYGDAFLAAVGSGHLQPGILSEWVQYDHEVTPNRLEHQKYMPYYSVFKDLYQSTKSLMHRMYELRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTR2</accession>
    <name>A0A398CTR2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02701">
        <property type="protein sequence ID" value="RIE02701"/>
        <property type="gene ID" value="D3H35_18775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="132" mass="14548" checksum="E2FA322E9CAF4ED7" modified="2018-12-05" version="1">MAHTKPSNAAERSAKSEIALTNSLEANMSELRNVFVDCSDIVFHSFSMKDGTECGVVSVKGLSDTQALERQVIAPLLVMEWEGNDKSARRLFSRLPASSCQEYEKIGELADRLCVGYPVVLVDGRPRRTLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUE2</accession>
    <name>A0A398CUE2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_18145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02604">
        <property type="protein sequence ID" value="RIE02604"/>
        <property type="gene ID" value="D3H35_18145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="26"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="186"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="394" mass="44731" checksum="048A6DD8FFF44D3F" modified="2018-12-05" version="1">MNTTRQPHIAYVSTFVPKKCGLATYTHHLREAVGLAKNGWSQDTVVAMCNPDERVDYRESWMWPVVKPDPEEYRRVAETINQSSVDIVSLQHEFGIFGGDAGSHVLELLQRLKKPVVTTFHTVFEQPQERYSDVQREIAEWSDHLLVMNRKAIGFLHSSFGIPHEKISFIPHGTPMPNRADRTLVRRRNGWENRKVAFSFGLLSRSKGIELALRALAIAVQAVPELMYVIAGQTHPEVRKHEGEAYRQELGNLVKELGLEHHVQMIDRYIPEEELASLITAADLYITPYPGMQQITSGTLAYAAGLGKPILSTPYCYARDLVQGHDEMLLPYGDVGAWSSKIIELFTYPGMLERWEKIVAEIGQNMHWPQIGAQHLRLFNQVVNEQRSTIADVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUG6</accession>
    <name>A0A398CUG6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small acid-soluble spore protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_20120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha/beta-type SASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02921">
        <property type="protein sequence ID" value="RIE02921"/>
        <property type="gene ID" value="D3H35_20120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001448">
        <property type="entry name" value="SASP_alpha/beta-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018126">
        <property type="entry name" value="SASP_alpha/beta-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038300">
        <property type="entry name" value="SASP_sf_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00269">
        <property type="entry name" value="SASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00304">
        <property type="entry name" value="SASP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="73" mass="7692" checksum="6FD27D4BFFB0CD1E" modified="2018-12-05" version="1">MAAGSRSSNTLVVPQAIGALDQLKYEVAQELGIAIPQDGYQGNMTTKDNGSIGGGITKRLVQIAEQQLAGQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVR7</accession>
    <name>A0A398CVR7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03967">
        <property type="protein sequence ID" value="RIE03967"/>
        <property type="gene ID" value="D3H35_08385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="159" mass="16464" checksum="4F94358E59009EAF" modified="2018-12-05" version="1">MNDNKDQVPPPPEGTQAFSPAFQPVNDYSYSQAPIKNSGTGIASFVLGIIGILGLVGTTMALFVSFASKVDVGTLVDDAGNLTMTEQELIDKLGSTIVLGFMYPLLLLIAFIGLILGIIGIAQKNRKKTFAVLGTIFSALPLLLVVLGLIVALAAGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWR7</accession>
    <name>A0A398CWR7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_10145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKC lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03651">
        <property type="protein sequence ID" value="RIE03651"/>
        <property type="gene ID" value="D3H35_10145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008844">
        <property type="entry name" value="Spore_GerAC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35789">
        <property type="entry name" value="PTHR35789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="245" mass="27750" checksum="C98CE0CE78F66B8B" modified="2018-12-05" version="1">MNPMPRRKFRPLAYASIVIMLAFQTGCWSSHEIETQSIYVGLAMDIGERADIEQEMEERSRGDYTKDAITETIQVLKPSGGGGESTKSGEQKKPYLNITQTGDSPFEILRELSLRTDRPPLGSHLKLIVIGSRLAQSYGLSRLLDFYLLDNDIRPSCLVFISNGRAAKTLETNVSETIPAIRILGITDNYFRNLKLLPPYRWQDWKLLCGPTEAFCFKTSFRRKGKSSLRERRSWTGRAKSSSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWS1</accession>
    <name>A0A398CWS1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal transduction histidine-protein kinase ArlS</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D3H35_12460</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03464">
        <property type="protein sequence ID" value="RIE03464"/>
        <property type="gene ID" value="D3H35_12460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041610">
        <property type="entry name" value="ArlS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18719">
        <property type="entry name" value="ArlS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="180"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="241"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE03464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="467" mass="52243" checksum="3B0CAC56025557A3" modified="2018-12-05" version="1">MPVKYKLASLSCGLILLLFIGYSLIQYQLVYRFMMESEKDNFRKTANEVAGYFSEQERENNQEEWEENKRFLERLVRDNQLFRLLDENGKPLVVIARGIPGEWVPSGTTDKEAIVSFHHGEDHLLLIRSPVRTDGFRGTMELAGNMESLDVLKDRLNRLMWVCGIAGIIISAAGGLFIARQVIVPVKRLTETMGSIKKDGLHERVSYSNNNDELSRLSTMFNGMMDELENSFLGQRRLVEDASHEFRTPIAIIEGHLKLLKRWGKSNPAVMDESLDAALQETARLKSLANQMLELTRAESGVRRECGSAIDASEILEDLVKDYVMLYPQREFHTELAPGLSVSIDANHLKQIVIIMTDNAVRYSADSKPVSLRAFSDAGRAIIEIEDQGQGIPEDELPLVFERFYRVDRDRNRKKGGSGLGLSIAKSLTEAYDGTIGIRSRSGIGTVITISLPLAGCDDGLKIDSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWT4</accession>
    <name>A0A398CWT4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_02445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05028">
        <property type="protein sequence ID" value="RIE05028"/>
        <property type="gene ID" value="D3H35_02445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="73" mass="8750" checksum="4AE1F9F20B54A37D" modified="2018-12-05" version="1">MLGMMLTDKECKELDYLLRKEMDEMLLDMSDRRLDGPVKEAISKRYKVIFRMYARFAAPRELSRYALGLRSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWW2</accession>
    <name>A0A398CWW2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_10355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03691">
        <property type="protein sequence ID" value="RIE03691"/>
        <property type="gene ID" value="D3H35_10355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="439"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="541" mass="60965" checksum="5C04EDF82FAD4DAC" modified="2018-12-05" version="1">MYNLLLVDDEEAVVKGLAYDIEWSDLTITGVYKAYSVSQALALMEQTRIDIVVSDISMPEADGIELAAEIRKRRPAVSIVFLSGHDDFVYAQKAIELGVAHYLTKPVDYEELKDKIRSTVRQLERELFREDALRSAKESLERMHPLLQERALHAWVVKGTESPLTHADKFSSAGLVFETGDVFIPVVLRAEDEEAGGPAGAEAGVREIALKELAEEWLLHGKESFFFPSEPGQWVLLYREPNLEEAAKAAKYMEEMAEPFKESAKRTLGCGISVFFGGMSEADGVSGAYRKLDSTVRRTNADAAGVILFADRPSAGAVAYERLESLYETPELSLLLDKLDMNKAMERIDLIFQEIDRREPVDMTALLEIYHVVSGVVIHASLRNGMSLAGWAGDNERMLYPFLSDGKSADLKKWCQSVIQAFILHLRGMENKRFNRLAEQAKRIVDEQYARDVSVAEIASYLYVHPNYLTRVFKSETGLSLMDYISKRRIEQAKGLLAQPGFKVYEVAERVGYESIAHFNRMFKRETGMSPKDYQKTISKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX84</accession>
    <name>A0A398CX84_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03821">
        <property type="protein sequence ID" value="RIE03821"/>
        <property type="gene ID" value="D3H35_09720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="301" mass="34988" checksum="54DB68BBD0505C05" modified="2018-12-05" version="1">MRPKVSFVVLNWNNFKDTKEIVQCLERLDYPNFDIVIVDNDSRDGSARMLEDCFPEHPFIRSPVNSGYSGGNNLGIEYALRMKADYVAIVNNDIVIDNDKLLAEVIAYMEDSGAEILGPKIERLETRETVSVYNDSPWWNLVRKVMVKNRRTREDDAQEEYNSLLLLGAFLVIKSEVFGTIGKMNEDFFMYCEENELLLRANLHRVAISYYPQVKVLRKMGKDERNYHIRRLYYMSRNKIHMFKLHSSGWSLLFLLFINFVSDVKKIVRFLFEGKFAFAATIVKGVIDGTGHVTGINPRYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXD3</accession>
    <name>A0A398CXD3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03654">
        <property type="protein sequence ID" value="RIE03654"/>
        <property type="gene ID" value="D3H35_10160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="243" mass="28482" checksum="F0CED0B2EA6093D8" modified="2018-12-05" version="1">MVAGLAQQWDEVPYFRRKVRSRAQQWDEVPYIRRLAAGLAPQWDEVPYNWREVRSRSPQWDEVPYIRRLAAGLAQQWDEVPHIRRLVAGLAQQWDEVPYIRRLAAGLAPQWDEVPYIRRLVAGLAQQWDEVPYIRRLAAGLAQQWDEVPYIRRLVAGLAQQWDEVPYIRRLAARLAQQWDEVPYIRRLVAGLEPQWDEVPYIRRSAAGLEPQWDRLRSNVPLEAGETGLGTITRQTFLLSQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXK8</accession>
    <name>A0A398CXK8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyl-accepting transducer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_05795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000026">
        <property type="protein sequence ID" value="RIE04517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04517">
        <property type="protein sequence ID" value="RIE04517"/>
        <property type="gene ID" value="D3H35_05795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="2">
        <location>
            <begin position="54"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="339" mass="35866" checksum="AC1E1929546B5F41" modified="2018-12-05" version="1">MSDELSVKDTRRTDEVGSIARSLQEMTGQLRTIVSGIRSTASVTAESAEELSANSEQAASGADQIADSMRELAAGADSQREGMKRGAEVTIQIRDGIWTIGDRTTSVAAVAEQATKHAQDGNETVKQAVEQMGTIARTVESSVRDARELHEKSKSIRGMADAIAGIAYKTNLLALNASIEASRAGEQGKGFAVVAGEVRKLALQSNETAAVISSKVEEIRAVIEAVAKRIEEGFVEVQSGTELVRQAGGTFQDIVGGIADMEAELREIASAGQEIGARIEELAALVEETEAISEASADRSQEAAGIAEFQSNSVRGVADAMGSLTQRIAELERAVNRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXL1</accession>
    <name>A0A398CXL1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methylthioribose kinase</fullName>
            <shortName evidence="3">MTR kinase</shortName>
            <ecNumber evidence="3">2.7.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mtnK</name>
        <name evidence="5" type="ORF">D3H35_08350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>5-(methylsulfanyl)-D-ribose + ATP = ADP + H(+) + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:22312"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:78440"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the methylthioribose kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.100" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03961">
        <property type="protein sequence ID" value="RIE03961"/>
        <property type="gene ID" value="D3H35_08350"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00872"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046522">
        <property type="term" value="F:S-methyl-5-thioribose kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01683">
        <property type="entry name" value="Salvage_MtnK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009212">
        <property type="entry name" value="Methylthioribose_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031134">
        <property type="entry name" value="MTRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01767">
        <property type="entry name" value="MTRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="4">
        <location>
            <begin position="32"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="111"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="246"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="404" mass="45037" checksum="1C6C10EFE14E093F" modified="2018-12-05" version="1">MSSYHPLTEAEAIEIAKSVPGVFNADAKLVSREIGDGNLNLVFHVSDPATNASLILKQALPYAKVVGESWPLTLDRARIESEALILQEKLAPGLVPKVYVNDNVLALTVMEDLSDHVIMRRGLIEGGTYPKFAEDISDFLARTLFFTSDLGLNQQEKKGLVRSFVNPELCKITEDLIFDDPYTNSPNNSFDDHLKEDAQALWDDSDLHFEVALLREKFLTHAQALLHGDLHTGSIFITPESTKVIDPEFAFYGPIGFDIGAIFANLLMHYAAQEHWTPDEATRRDRRAYLTNTIRDIWAGFDRKFRELWNENGVDRISRTPGYQDDYMNRLLKDAFGFAGAKIVRRIVGLSHVADIDKIPDAAVRAKAQRLSLAIGTSLIKRNRNAASIEELIGIAESAVAASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZD8</accession>
    <name>A0A398CZD8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_06690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04294">
        <property type="protein sequence ID" value="RIE04294"/>
        <property type="gene ID" value="D3H35_06690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_2" evidence="3">
        <location>
            <begin position="281"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="614" mass="68741" checksum="AAA93C7D22F12142" modified="2018-12-05" version="1">MSLRKKMLLLFIIDMAVIWFSIWSSYALRFSGNIPESFLSQMSVYGLVSSLLCGLSMIYFGMYRKLWQYASVGDLILICKSVVVGSLASIVVTTICYGQKLPLPVVLRNVETMLLLIGGSRFAWRMLRTRVIKTDGTRIRTLIYGAGECGAMIAKELLNPNLRDRELVGFMDDDDTKHRMHIFGVAVLGNRSRLSDIVSEYRIKEIIIAIPSAPRSEITEIISRCVTTGVKVKLIPAMDHVIKGNITFNTVREVEVEDLLGRESVATDLEGIANYVHNKVVLVTGAGGSIGSELCRQIIGFEPDKLLLLGHGENSIYTIGMELRNIFPESQTISIIADIQDRSRMEEVFKEFHPHVVFHAAAHKHVPLMESNPTEAIKNNVFGTKNVADLAAKYGAERFVLISSDKAVNPSSVMGTTKRIAEMYIQSLSTHSKTKFAAVRFGNVLGSRGSVIPLFKEQIARGGPVTVTHPEMVRFFMTIPEAVQLVIQAGAFSDGGEIFVLDMGKPVRIVTLAEDLIRLSGFEPYKDIPIEFSGVRDGEKLFEELLFVEEEVAATQHDRIFIGMLNEINRFELEKEFKRLEQLIHEEKKSIKVFLDQMVPSAHRKSNRDLVRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZE8</accession>
    <name>A0A398CZE8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04304">
        <property type="protein sequence ID" value="RIE04304"/>
        <property type="gene ID" value="D3H35_06745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="221"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="386" mass="43884" checksum="156892046516414A" modified="2018-12-05" version="1">MKALFLHDNLMNKHNNYFYSNGLPSNVWTERYLKVFDQMVVCTRVVEAVEDCSKTLKLSSADNVEFDLLSIGVNNISFLSKRKFIEKHIEQAVLKCGYVIARLPSIIGQIGLKYAKKHKKPFLIELVGCPWDAYWNHSLKGKVIAPFITWRTKSAVKTAPYVVYVTNSFLQGRYPTSGKTIGCSNVALTEFDEHVLTKRTDKIKGMSNRPIIIGTTASVNVRYKGQQYIIEAISMLNKQGYNFEYHLVGEGDNSYLRSVAEKFGVTDKVKYLGPMPHAQVFQYLDNIDIYAQPSRQEGLPRALIEAMSRGVPSIGSNTAGIPELLEKESIFKNGNIGDICGILKKMDQKTMLIQAKINFEKSKEYAKSILDERRIEFFKEFRDDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1E9</accession>
    <name>A0A398D1E9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsH</name>
        <name evidence="7" type="ORF">D3H35_02310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05004">
        <property type="protein sequence ID" value="RIE05004"/>
        <property type="gene ID" value="D3H35_02310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="132" mass="14674" checksum="CE8964D0EAFE082C" modified="2018-12-05" version="1">MVMSDPIADMLTRIRNANLVRHEAVELPASTVKKQIAEILKREGFIRDAEYVEDNKQGLIRIFLKYGPNNERVITGLKRISKPGLRVYTKANEVPRVLGGLGIAIISTSKGVVTDKEARQGKNGGEVLAYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCR0</accession>
    <name>A0A398CCR0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00195">
        <property type="protein sequence ID" value="RIE00195"/>
        <property type="gene ID" value="D3H35_29600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011396">
        <property type="entry name" value="UCP030850"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030850">
        <property type="entry name" value="UCP030850"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="174"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="291" mass="33472" checksum="4A18F293DD1E5802" modified="2018-12-05" version="1">MNDEELRKRIANLSIWKKNGQRAPHKPLLLLFALAQLQQNQTILSYADTRAKLRKLLFEFGPPRKSYHPEEPFVRLTTDGIWKLNIPVNKHKFSDKQLITDHAAGGFDPAVLALLQGSSRLIQEIAEQLLHDHFPQSVHQDLVDEVGLQLSLATKRRRDPDFRNKILKAYEFSCAICGFNVRLGHNLVAVDAAHIQWHQAGGPDSEENGIALCTLHHKLFDRGVFTITGEREMLVAEEAHGTQGFEEWLMRFHGKRIRAPIHPVYQPKETFIEWHVREVFRGPARYNATYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD10</accession>
    <name>A0A398CD10_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000051">
        <property type="protein sequence ID" value="RIE00600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00600">
        <property type="protein sequence ID" value="RIE00600"/>
        <property type="gene ID" value="D3H35_27460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="127" mass="14351" checksum="BEE6359F2FA77A68" modified="2018-12-05" version="1">MHSAHLSLDYGNPADPATLKHADFVFDKDRAEARRFEVFMNERLDTDTSIPSNTILILYRGGRKQDKLRAAAPAKGRSDAAAQSFRGHRFLELQVKASNVDWGVVDSIEVRLEYRQPGGELLSKYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD29</accession>
    <name>A0A398CD29_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000051">
        <property type="protein sequence ID" value="RIE00620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00620">
        <property type="protein sequence ID" value="RIE00620"/>
        <property type="gene ID" value="D3H35_27560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="200" mass="22335" checksum="F23A4192A9D7DB06" modified="2018-12-05" version="1">MLIDQASRRRRRQRLLGARPAFSNLKCCVPDAQAVYHLLVDAFLFDPSQIWVYLDSKATSSNIRQAIRYMLSISEPGDVACLYFSGHGGLHSITADTYYQTIIPYSGSYISDWDLALAAESLEPSKVNFTVILDSCQSGGMHEESEHRMLLNPFVMRAISSTALSLRCRKSFLRVTVPNVQAYSSNVNNVRQGDALLLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD39</accession>
    <name>A0A398CD39_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_27065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00630">
        <property type="protein sequence ID" value="RIE00630"/>
        <property type="gene ID" value="D3H35_27065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007892">
        <property type="entry name" value="CHASE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05228">
        <property type="entry name" value="CHASE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="6">
        <location>
            <begin position="507"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="709"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="3">
        <location>
            <position position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="852" mass="96053" checksum="C506720EB4BD9155" modified="2018-12-05" version="1">MKSRRKHRSFTAELLGWIVLLVVLPVGLFLAYFYVSSTDNTKRMEEEKARLTNRSAQKSIESLGDSILGVTVTNGYWEQSRQALLNDDKEWLQINIGDMPSIVPNIDFAAAADLNGDVLVQSGDIAELKVHIGFPFLLDKLRSSPTFTGVLDTSRGLALIAASIVTDETGKEPTAGYLVTGRLLEDADLRKVQDTLQADVSVLLNSGQFLTSDSSSERSGMQAMPEKASIPKTTFQLQRIEGSYQSLMTEPFLDMAGHVIGAIRTQSVSVSSAQAADNVRTLSLYAIGILMLLIVLVVYLLRRRIVLPLRHFTASLEEVAAGRKLEKMPKQVLQADAEIVEAIQQIADWNQLLERTVRNRTADIRTLLDHTRHGILSVGPELKVKEEYSVECVRLFEGEPGGLPIAELLYPHDEQEASLMQAILSDYFAERDEFKRDMIFSLLPDEMRINGRTVKAEYIPLSEEESADGSGESVMLLLTDLTETRDLESKMQQERRVLEMVVQSVTHPEDYANIVRDFESFRHTEIRELMASDAESPQEKAMRIYRMVHTFKGSFGFLRFVHIIPRLHELETDLLRLMDNDSLSLIELTNFLRGQRLEDWLQDDMEVLRSVLGPAYEQLLLEHGVKLDKEQWSEIESMLDQTLQQQDDRIWLEKFRTWRYKKAETLFRPYSSYLQEMAERNGILLHPVELKGGEIPVDPEHLYGFARSFVHVVRNAVVHGIEPPDERAAQGKDEYGTVSFSVERVDGNLLITFEDDGRGIDADALIRKARQQGLETEELTEEEALGLIFEEKLSTSQQVTEWSGRGVGLSVVKEEVEQLGGTIEIRTKIGAGTSFVFTLPEGSWGGDDRIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDB9</accession>
    <name>A0A398CDB9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00693">
        <property type="protein sequence ID" value="RIE00693"/>
        <property type="gene ID" value="D3H35_26195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="65" mass="7188" checksum="E52374336280A1A4" modified="2018-12-05" version="1">MRIRSVPRSRIEPLGSEEGREARSESRVPFLSAAAFPPAKYSKANRYRPTDSELTDALIASPLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE58</accession>
    <name>A0A398CE58_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2273 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00725">
        <property type="protein sequence ID" value="RIE00725"/>
        <property type="gene ID" value="D3H35_26380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018730">
        <property type="entry name" value="DUF2273"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10031">
        <property type="entry name" value="DUF2273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="76" mass="8921" checksum="46E058A5AD6B9254" modified="2018-12-05" version="1">MWKIWWDTYGGRATGVAAGLLFALVYLISGFWDMLFCVLIIGVCYWFGKQKDERAGALLPWDRLTEWVTDRFPRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEK8</accession>
    <name>A0A398CEK8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01060">
        <property type="protein sequence ID" value="RIE01060"/>
        <property type="gene ID" value="D3H35_21765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="64" mass="6967" checksum="911DA8DD85FE5B06" modified="2018-12-05" version="1">MARSITLTTRGNQVNNLAKSIEARYRQALGQEAEMPEDGYYGEDIVGFAKELGSGRRQASVFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEU7</accession>
    <name>A0A398CEU7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_05345</name>
        <name evidence="2" type="ORF">D3H35_22900</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000024">
        <property type="protein sequence ID" value="RIE04591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01243">
        <property type="protein sequence ID" value="RIE01243"/>
        <property type="gene ID" value="D3H35_22900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04591">
        <property type="protein sequence ID" value="RIE04591"/>
        <property type="gene ID" value="D3H35_05345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="171" mass="19905" checksum="0A3718D96F4FD59C" modified="2018-12-05" version="1">MSAFIFPELETGRLRLSILTLNDSAAVYKHFSDENVTRFMDIDPCKDIQEAKEIIQYHIDDTGSRWGIFSKVDSQFVGTCGFHCWVQGEQPRAEIGFDLAKEHWGKGLMQEALHPVIEVGFNQMGLEIIEATVEQGNDRSINLLRKLKFEKETELRDQLIYFYLNRQSWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEU9</accession>
    <name>A0A398CEU9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_25460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00985">
        <property type="protein sequence ID" value="RIE00985"/>
        <property type="gene ID" value="D3H35_25460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="321" mass="33436" checksum="8C6F5852356F5CE8" modified="2018-12-05" version="1">MTADASGKGNSVDWKLLYRKYGILLIFVAIMIISAILNPNFLEPANLLNILRQNSVIAIIACAQTILIVSGMIDLSAGFVLTLSGCLACGVMVNTGSVPLALGTGIIVGGACGWVNGFLVTRFGLQPFIATLAMANVASGITQVYTGGSAISKIGDLKYVGQGYLGLVPLPIVIMLLIVVLTWVIMKYTRFGLYIYAIGGNEKATVASGIPVNRAKRRIFGLSGLFVGLAGVVLMARLNSGQPSVGAGYEFDAITAAIVGGTSFNGGVGNVFGTLIGALIVGMINNILNLMNVSTQYQLIIKGVLIAAAVIIDLRTKSSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF30</accession>
    <name>A0A398CF30_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Cysteine synthase</fullName>
            <ecNumber evidence="5 11">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cysK</name>
        <name evidence="13" type="ORF">D3H35_23450</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5 11"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01333">
        <property type="protein sequence ID" value="RIE01333"/>
        <property type="gene ID" value="D3H35_23450"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005859">
        <property type="entry name" value="CysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01139">
        <property type="entry name" value="cysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 9 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="8"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="9">
        <location>
            <begin position="183"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE01333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="313" mass="33132" checksum="6D9FF005E0BEA18C" modified="2018-12-05" version="1">MAKIVQSVTQLIGDTPLVRLNRLVPEGSAEIYVKLEYQNPGSSVKDRIAISMIEEAEKRGDIKPGVTTIVEPTSGNTGIGLALVAAAKGYRAILVMPETMSLERRNLLRAYGAELVLTPGSEGMNGSVKKAEEIAAENPNYFLPQQFKNPDNVKIHRETTGPEIVEAINSLDGKLDAFIAGIGTGGTISGAGEVLKQNFPGIKIVAVEPTASPLLSGGNPGPHKIQGIGANFIPEILNREVYDEVITVDNEEAFETARASAKKEGLLVGISSGAAIFAALKVAKELGAGKRVVAVVPSNGERYLSTPLFNFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFE6</accession>
    <name>A0A398CFE6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spore protease YyaC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yyaC</name>
        <name evidence="1" type="ORF">D3H35_24070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01443">
        <property type="protein sequence ID" value="RIE01443"/>
        <property type="gene ID" value="D3H35_24070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009665">
        <property type="entry name" value="DUF1256"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06866">
        <property type="entry name" value="DUF1256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02841">
        <property type="entry name" value="spore_YyaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="207" mass="22562" checksum="725867C1B5ED4BDB" modified="2018-12-05" version="1">MNGAWDKRQGSAAEAAALSLKIPFNEPTVLHRLSQRIEHYLEPLPQDRRIVVVCVGTDRSTGDSLGPIVGTFLHRENSTLFDLYGTLDEPVHAMNLGDTLLKIMRTSKHPYVIAIDACLGQVSSVGCIQLGSGPVRPGAGVNKELPPVGDIHMTGIVNVGGFMEYFVLQNTRLNLVMKMADIIAQSLMRAIQNVRNAESVIPYAMPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFI0</accession>
    <name>A0A398CFI0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_22500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01175">
        <property type="protein sequence ID" value="RIE01175"/>
        <property type="gene ID" value="D3H35_22500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="21"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="283" mass="32727" checksum="0DB312AD53738DED" modified="2018-12-05" version="1">MQKVILNNGVEMPILGFGVFQISDQNECEQSVYDAIMAGYRLFDTAASYLNEEAVGRAIKRSGVPREELFITTKLWVQDAGYERTKRAFEKSLNRLQLDYLDLYLIHQPFGDVFGSWRAMEELYREGRVRAIGVSNFQPDRLIDLIIHNEVTPAVNQVETHPFNQQIESAKFMKENNVQIESWAPFAEGKNNLFQNEVLVSIAERYNKSVAQVVLRWLTQREVVVIPKSVRKERIIENFNIFDFELSQGDMDSIAALDTEQSLFLSHRDPEIVKWMGTRKLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFJ9</accession>
    <name>A0A398CFJ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01966">
        <property type="protein sequence ID" value="RIE01966"/>
        <property type="gene ID" value="D3H35_14440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="300" mass="33203" checksum="EC6D58559C3D04D7" modified="2018-12-05" version="1">MTTPAPYCNATARSSFVTLPFAWKPYPPQGEAYTAEGYVSWAKKSSADIFQVPLAYVDDMSREGLIKPLDAWIKRDSYDIESLYKPVVQAIREAGAGQLYGLAPSFETYALYYNKTLFNAANIPLPKDGMTWEEVWNLAAQFGESPKGNDIAGLSFGRYSPAASLSLLGQSMGLRLTSADGKLPTIDTPGWRKALEPLARGWREGWISKQQPKKREGDILMKDLYMEDPFLTGKSAMSFASSIYMNDIRSAEKLIPFQDKWGAVTQPTATGNPNDSRLFGVSYIYAINSSSKDADAAWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFN4</accession>
    <name>A0A398CFN4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_26300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00712">
        <property type="protein sequence ID" value="RIE00712"/>
        <property type="gene ID" value="D3H35_26300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="66" mass="7213" checksum="BEF4FA202B8C8F6D" modified="2018-12-05" version="1">MNADQLKKGQYIYLTRRAIQYLNVKKAATGASLSALIESMIEADMSSNPNMQAGISSLFGQSTEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGB8</accession>
    <name>A0A398CGB8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000041">
        <property type="protein sequence ID" value="RIE00992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00992">
        <property type="protein sequence ID" value="RIE00992"/>
        <property type="gene ID" value="D3H35_25260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="66" mass="7263" checksum="8CB191461A5FA32A" modified="2018-12-05" version="1">MAAILCPCVRAKFRGGSQGPDKFCPVCDNEIDGYRTLRIGIDEETRKTKKTAIRSLGSAEDEEDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGE3</accession>
    <name>A0A398CGE3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01803">
        <property type="protein sequence ID" value="RIE01803"/>
        <property type="gene ID" value="D3H35_13490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="193" mass="21652" checksum="82D45D5D1771B5FE" modified="2018-12-05" version="1">MNMNIAIVMGHPDSGSYCAALAAAYGKGAIDRGASVRTIDLSRMEFNPSLKHGYRQRTELESDLAAAQETIRWADHLVFVYPTWWGTMPALLKGFLDRTLLPGFAFKYRDNSVLWDKLLAGKSARLIVTMDTPSWYNRFVYGKPGHRAMKIATLQFCGVKPVKITEIGPVRPSTEQARLKWLGKVEKLGTRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH51</accession>
    <name>A0A398CH51_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_29835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00238">
        <property type="protein sequence ID" value="RIE00238"/>
        <property type="gene ID" value="D3H35_29835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="311" mass="34657" checksum="8ABB4F361C5DB006" modified="2018-12-05" version="1">MSLVQFKDVVKKYGSSLSVDHLSLEIGEGEIFGLLGPNGAGKSTTIKMLSGLLDMNQGTIRLEGYSVADDPIEVKRRIGLVPQDLAIYNEMTARENVTFFAKLYGLRGKLLQERVSEALEFVGLQDRQKDKPQSYSGGMKRRLNIACAIMHHPKLIIMDEPTVGIDPQSRNHILESVRKLNQMGSTIIYTSHYMEEVSAISTRVGIMDHGRLIACGTHEELRSLVAKEEKIVIEGQNISAEALNELRGHPSIREALLEEGKLELYLPSANAYLQDILFILSKHQATIQSLTKQEPDLEALFLSITGRTLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHC3</accession>
    <name>A0A398CHC3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02153">
        <property type="protein sequence ID" value="RIE02153"/>
        <property type="gene ID" value="D3H35_15505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017244772" evidence="1">
        <location>
            <begin position="28"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="266" mass="28492" checksum="2DF5E0095E25F50A" modified="2018-12-05" version="1">MNTAKWTSALIVSLILSALAANPIASAFSIRYDSSVRASLNKLPQPSKPIALYTDAIGLQQQLDGIDGRIAKLHAENEQALLGVRQRIKLIDAGKLSRLDAQAKQAKQRYQPLFDDYRAANQQLTAAKYIPGKEIKAVLRLKADLMKPAVQLARQDIRAKEAALKEAKEATAKTVKKIKDVLGGISSSKAKIQAEKAAAAIPAKHLSSAWSAAGKSLKKADSKGVTEALSDLNSLFKQTIARKQAIQALEVQIGGIIAKANSLIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHN5</accession>
    <name>A0A398CHN5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_24470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01512">
        <property type="protein sequence ID" value="RIE01512"/>
        <property type="gene ID" value="D3H35_24470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="70" mass="7839" checksum="46DB5FD35389DBEB" modified="2018-12-05" version="1">MLTGPDAEARCKLALDILSDMISKHLAKQASPELREATLAIMEKETEEQLDFEMTSELLVTTDFRVRSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHN6</accession>
    <name>A0A398CHN6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L,D-transpeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_27060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00629">
        <property type="protein sequence ID" value="RIE00629"/>
        <property type="gene ID" value="D3H35_27060"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="363"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="126"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="504" mass="54240" checksum="411CE30C09C8A671" modified="2018-12-05" version="1">MNKEKQIELQIQQFYDNVPNVDDDMPLKEYLLKHEDSRMAWYLLGKQYEAKGEDAKALYCFGQSGDIYEAFEGKPNPGIRAEAPKKDKGNRAGWIVAAGILLLLIGVGIPIMKEIMAQKQEEAKSAKPTIADSASGGLPEKTPEASLPLEASGGLGEKGTTPTAGGGSDPGLIAAAAYPDGDGQQALGQLLTHNPDASPLLLVSSPTLGRYYDWLKGGSPIASVTGSSQSKAAAVNWYDSKWCNCQPGEASGAQASIPAAWKPLQEEKLALVSALASYKQQYGKLPGSAAALNGDYPNNRIAGWSEEMSGWLKELTAEKPIDGKRDETVGVGWPVSFSSPESAAGQATPAGAWRPFTEQPLEIIVDKTRHRLAVVSGDVLIRNYEVGLGGKRTPEGPFVISEKVRNPNGRTDGAFGSRGMTLSDTRYGIHGTDEPDSIGKDESLGCIRMKKADLEELFDLVPLGTKVTISKGGLPVEVRIPEQRFRLPQEKNETNPNKVYDWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHR0</accession>
    <name>A0A398CHR0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_24640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01542">
        <property type="protein sequence ID" value="RIE01542"/>
        <property type="gene ID" value="D3H35_24640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="195" mass="22421" checksum="1A8B884330C20B7C" modified="2018-12-05" version="1">MVNQEDPRVLRTRQLIIEAFRDLLRRKGFGAITIKDIAQKATINRATFYAHFEDKYALLDEVTEQVFHEMIPEQVANAREFTDEICEQLILQTHRYIVDFYQTCRMDSKPMATLVDEKIKKMLLQTIESIFLKGATHLGVGRNPIKVMAAMTGSAIYSAAHYWLNVEEKDRTDGLVDIVRSYVMNGLGLYRDGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHT2</accession>
    <name>A0A398CHT2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00438">
        <property type="protein sequence ID" value="RIE00438"/>
        <property type="gene ID" value="D3H35_28945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017208755" evidence="1">
        <location>
            <begin position="26"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="140" mass="15278" checksum="79BB4908ECAB72BD" modified="2018-12-05" version="1">MNKGLLKIFAILTLVFSFVNQPATAAVKTIKVKVSLVSVELIENNHVGNEWYTSGSVNGKEIVEGSSVILKLKPAESVKLRAYAEEQDKIPDSGSSDSSIKASSISKKISKALTVTVTENRGRYSGNTANWKFVFEIQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHX5</accession>
    <name>A0A398CHX5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_25040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01612">
        <property type="protein sequence ID" value="RIE01612"/>
        <property type="gene ID" value="D3H35_25040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="323"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE01612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="607" mass="68816" checksum="CA01626A4DBEC075" modified="2018-12-05" version="1">MGRKRRKLDALKRQSIKIKLTGTTIVLFLVAISVVSLLSYNRYTLDFQKQSNERTQQILDQLSLNIDNYIDDLFRLSLSPYNNLQVLQLLDSPAPQSEYEQLKRERQVEDFLNQMIVTPRLDILQVYIITSTDVYTNGRAVNVEPLDPDFREQEWYKNALNTQKPTFLPAQTTIKSNPHVKVFSVVKQLRSLKDTTRPLAIIKVDANYSGIENICDKVNLGDRGGLLIADRNGNVIYSSIREVDTGTLYEAVRSSDASRFHLKEHGENYLVASSEITRAGWSVISVNSVNELNKSAIVTRNFTIVIAAGCALLACAVLFFMMRVFLRPLFQMVSLMKQVKLGNLSVHFPDSKSEDELAYLGASFNSMIERIQEMLTENTRLTKEIFETRFLQKEAQIQALVSQIRPHFIYNTLHTIGALIQVGRPEQATDNLEKLSLILRGYANIDQTITLRKEIELLEAYLGIQQSRFGDRLRYEISIDEALNDFLIPAILLQPIVENSVIHGCEERKERTTVRITGRIAGHMLVLAVEDDGNGIPQQKLAELTDKMSSDVRLQLERPGEWELRSGIGLINVHNRLRMQYGEPFGLKIDSTPGLGTIVTATLPYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI47</accession>
    <name>A0A398CI47_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide pyruvyl transferase CsaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">csaB</name>
        <name evidence="2" type="ORF">D3H35_14770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02025">
        <property type="protein sequence ID" value="RIE02025"/>
        <property type="gene ID" value="D3H35_14770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019896">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase_CsaB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03609">
        <property type="entry name" value="S_layer_CsaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="25"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="380" mass="41854" checksum="56A14F68BA778209" modified="2018-12-05" version="1">MQLADQGGNGRTRKYVLSGYYGFKNSGDEAVLKSILTALEQEALARGESVEPIVLSSDPEWTKNQYGVDAVHRMKLGEIWSALRKSDGLISGGGSLLQDATGLGSIPYYLGIMEMARWCGKPTFVYAQGIGPVNRGVYRWPISRAFRKAKYVSVRDEESAELLRRFGVPMTGIAVVPDPVMGLPLAGSAEVPEESAKEARSTDATPIVGVSVRFWRGDRADLDRIADALGALAGLRSVRLRFLPFHRGADDDASRYVMERLGGAAPVELAPAYEDPQRMLQEVSRCDLLFGMRLHSLIYAANRGLPLLGLSYDPKIDQFLRRLGQKAVGSTEALDPKRFAEQAAKLLDDPERWRQSAGSAIERLKREAVEPAQRILAYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CII2</accession>
    <name>A0A398CII2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_15700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02185">
        <property type="protein sequence ID" value="RIE02185"/>
        <property type="gene ID" value="D3H35_15700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017353110" evidence="4">
        <location>
            <begin position="21"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="5">
        <location>
            <begin position="90"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="562" mass="61225" checksum="45EE95E632473223" modified="2018-12-05" version="1">MKVRKVVTGLMALTLVGALAACGNGNNNSGSSSSPSGSATSGNTGKKQELVMNYRAEPPALDVSIAESAASFTFLGAISEGLYRLDKDMKPQPALASELPTVSADGLTYTMKLRDGIQWADGTPVTAQDFVYSFKRTLDPATKATYAFVVAWIDGGEEIMNAKTPEAVKAAQDKLGAKALDEKTLEIKLDHPVPFFTSMLAFLNFYPQKQSQIEAAGAQNGTEADKVLGAGPYVLTKWDHEQTIVLEKNPKYWDAANVKINKVTLNIVKDTATGLNLYETNATDYADIKGDQMKAYEGKSELHIKSELVTGYLNFQQTKVPAFANKKIRQAFGAAIDRAGLVNTVLMNGSVPSTGYVPNGNSDGNGQEFRKVVGDIEVPFDAAKAKQLLAEGMAEAGIKDVKEFGKLSIIGDDTETGKKLLEFVTSQLKTNLGVDVSAEPLPHAVRLERELGKNYTIVSSLWGADYNDPMTWLDMFINDGPFNTQDWKNDEYTKLVKDAQTELDLAKRSEMLVKAEKILMDDAALYPLYFRSSPFVIKDKVKGLILPPYGPDFELKWASIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIJ4</accession>
    <name>A0A398CIJ4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YjbQ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02200">
        <property type="protein sequence ID" value="RIE02200"/>
        <property type="gene ID" value="D3H35_15785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="135" mass="15291" checksum="7C30593F18279BE9" modified="2018-12-05" version="1">MTTLFRETLSTSRRDEMIDITRQVALTVSRHGMTEGIALIYCPHTTAGIAINENADPDVKHDVLMRLDEVYPWNHPKYRHAEGNTASHLKAITTGTSQAVIVAEGRLALGRWQGIYFCEFDGPRQREFFVKLMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIN9</accession>
    <name>A0A398CIN9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Biotin carboxylase</fullName>
            <ecNumber evidence="5">6.3.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetyl-coenzyme A carboxylase biotin carboxylase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">accC</name>
        <name evidence="8" type="ORF">D3H35_26395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00728">
        <property type="protein sequence ID" value="RIE00728"/>
        <property type="gene ID" value="D3H35_26395"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004549">
        <property type="entry name" value="Acetyl_CoA_COase_biotin_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00514">
        <property type="entry name" value="accC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1 5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="7">
        <location>
            <begin position="2"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="121"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="461" mass="50800" checksum="72F53FDA043ABB2A" modified="2018-12-05" version="1">MKFHKILVANRGEIAVRIIRACRELGIATVAVYSEADRESLHVRLADEAYCIGPTASKDSYLNLTNIMSVATLTECDAIHPGYGFLSENADFADICETCNITFIGPSASAITRMGDKSVAKQTMKEADVPVIPGSDGLVEDIEEAALVAREIGYPVIIKATAGGGGRGIRIAEDEEMLVREITTAQQEAQKAFGNSGVYLEKFLTGMKHVEIQIIADKHGNVCHLGERDCSVQRRRQKLVEEAPCPVLTPALRERMGQASVRAAQAVQYSGAGTIEYLLGPDGQFYFMEMNTRIQVEHPVTEMITGIDLIKEMIAVAEGEPLSFAQEDVKLNGWAIECRINAEDSERNFMPSPGRIGFYLPPGGPGVRVDSGAYPQYLISPHYDSMIAKLIVWAPTREEAIARARRALSEFMIEGVKTTIPFHQKLLNHPIFERGTFDIKFLEEHDINDPYADSSGNEFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJC0</accession>
    <name>A0A398CJC0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">L-threonine dehydratase</fullName>
            <ecNumber evidence="11">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ilvA</name>
        <name evidence="13" type="ORF">D3H35_15920</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="11"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02222">
        <property type="protein sequence ID" value="RIE02222"/>
        <property type="gene ID" value="D3H35_15920"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1020.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011820">
        <property type="entry name" value="IlvA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038110">
        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02079">
        <property type="entry name" value="THD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51672">
        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT-like" evidence="12">
        <location>
            <begin position="340"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE02222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="423" mass="46206" checksum="4793B42018E7A9C4" modified="2018-12-05" version="1">MSHSSRSDLKVPLTDVLHAAQVLQDVAVPTPLQYNLGLSSKFGCNVHLKREDLQIVRSFKIRGAYNLIASLTEEQRSRGVVCASAGNHAQGVAYSCRKLGLMGIIYMPSTTPRQKINQVKLFGGENVEVRLLGDTFDDAYAEAIRVSQQEELPFVHPFDDPRIVAGNATVGKEIVEAGIHPVDVVIVTVGGGGLASGVASYVKAVNPEAKIIGVEPEGAPSMRKALDSGEVVTLEEIDKFVDGAAVKRAGDLTFEICRELLDDVIVVPEGRVCTTILELYNEHAIVAEPAGALTVAALSTIDPAFLQGKNVVCVVSGGNNDVDRMQEIKDRSLIYEGLKHYFMINFPQRAGALREFLDDVLGPNDDIVQFEYTKKHNKENGPALVGIELKSREDYEPLVERMTVKGFKFHELNKDPLLFNLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJI6</accession>
    <name>A0A398CJI6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02863">
        <property type="protein sequence ID" value="RIE02863"/>
        <property type="gene ID" value="D3H35_19750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="145" mass="16183" checksum="5C843974EDDEB8D2" modified="2018-12-05" version="1">MRAAIGAPINARPRLGVKPNPNKKRPSTGRKRAVKARKRRGKRIVSKKRPLSPEQPQQPQQSQQSQQPMRTYEQGYSEGLFDGGEKFVEQHHPGDLIIPDLSVEGAVAAGIQALRPTAFPCSGLTPWRRNWSRACARRDLTHSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJJ8</accession>
    <name>A0A398CJJ8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_17700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02525">
        <property type="protein sequence ID" value="RIE02525"/>
        <property type="gene ID" value="D3H35_17700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="208"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="268"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE02525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="475" mass="54467" checksum="E8CB341F37A2510F" modified="2018-12-05" version="1">MKNIPLVLKIWLVFAALTLSLFAMLALSLPWTLKSFFTQQISAILRESHAMFASDPSRGAFPLRIGNEVFPLLPTIVLPPLTDLQEEMLMIAPQTVDGPAIQHFALLAEGESYPLGSDLPLSFQIAIRGDAQKQKDTMHSYTFRSDNRTLFYVISKQPKKPKGKPVFLVSYTWDKYRNGLVMTMFWRLMILMVAIILVSWLPCLWFARYLSRPLVLMEKQAGRMAEKDWHEPFILNRKDEMGRLAQAIEAMRQRLVRQDNAQQFFLQNISHELKTPVMVIRSYAQSILDGIYPKDSLASSAETIVNESQRLEKRIRDLLYLNKQNYLFTRERKLVSFDLAQIISDCIERLRYRRPELLWHIELAPIEMIGDSEQWGVAIENVIDNQLRYARHKIRVTVAAADQGTNAATWIVRIGNDGPPIGENEMEGLFDPFQTGQGGEFGLGLAITRQILSYHQADIRICNEPEGVAYYLYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJQ6</accession>
    <name>A0A398CJQ6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02585">
        <property type="protein sequence ID" value="RIE02585"/>
        <property type="gene ID" value="D3H35_18045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="913"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1204"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1316"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1358"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1211"/>
            <end position="1231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1482" mass="156493" checksum="0C0CC96FACC88C4A" modified="2018-12-05" version="1">MGRTAVAPRSKGGLAMRHERFAGDILGKYGPIRRGDKSGAPLVFRSKSDAKTKPVKATPSTVHVHVTMPVQPMPPLAKEQMKPREKAVVKERIVEREKIVEKLVVSRTVVVREVERIIREQRLLREQAVKGPVAGAHENGKSGVEREVGQERGSAKSANARTESGSQIAKPVAPEAKASQHTGRSAKQAKKQQRQFPALTAKPDSQQSPPMPKPELDANEPPFGERKDEAAAGVSAKSAGLTGLSGNWKLSAAIPVGLVKGNLGIGKDKQPRKARASFSPLILINRLLRGSEEASLPVRYRFANKRKSAVSGVNRTERRDLQDNRSDDGIIADGRTELPTEQGAKGVSSEGMNDASLTTVRAWLRRTLLSSRKSDFLKLNRHEILSHPSVPLTFRRLAEAGTMAATRRGSLESSSHAGTVALKLQLRRHEGRQTVFIEQQAPTGGSSAANRPMPQPKSHDERPSLEAGRQAPDSGQPIAKGSDAPQSGLHRRTERDVLVSSLPQGEESHILPSDSRTVSGNSIGRAPLTARPSTSTVDTPRKGSRELYSRVFLSHRQPKGVVARSKNARRLSEERELVRPIEKRTLMPANLRNPLSVTAGLSPRLPLVFHRLAERKGQPDQTRHHSADAANTPSISKGPDISSAASGKVSGRREELRDRGRRDAHVDEAPEAGIGSALNSSGPIPTNSDGALSPERMASLSESRSTPALAGTVKNSAKPAEDDSGSFIYPAAKTWWKGRALRFSHLAGKRPTDQATSADLRFPASGGGRNSVPAKSEGAPGAQSAFDLAGSAARGIVLRRGMTLGNGIALLAHKRPSANGAASGKLSLERSSDATASNVHSEAKPFGNLDGSASLLHQKMSANEPKSAISVRRSTPADGQAIAAQSRLRTIANGGQPLPTTLKRISSNNRIGASQLQQPPSANGGQSVPLSHKRAATSGRTSATGSQQRPSVNGGTSAPLSLQRPSVNGGTSAPLSQQRSSVNSGTSAPLSQQRPSVNGGSSAPLSQQRSSVNGGTSAPLSHKRSAPNGQTSATGSQQRPSVNGGTSAPLSHKRSASSDQTSATGSQQRPSVNGGTSAPLSHKRSASSDQTSETGSQQRPSENGGTSAPLSHKRSASSDQTSTTGSQQRPTVNGETSAPLSHKRSASSDQTSATGSQQRSSVIGGASAPMSHKRSASNGQTSATGSQQRPSILMLHKRAMLNDRTTARQSKRRSPVNGGQPAPFTNSRSALNDQNRASQFQNRAFANGETTASMSHIRAASNDRTTASNSQLRPTAVDEQTAISGQAATMSHNWQSPMATMSIALSHMRMLTPDTESSMLSKNRQSPAGTATAMLSHKRQTAAASIAVADRPTIAARARVAAPHQPPAPPQQAAAAAQQAAPHAELAHAAPASAGRRGQPPTAQAPRAPAAALELRRSAPQASPAQPEPSREIKIDAPPQIDAEQLKQALSSLPQLNPDQLADQVYKSLMKKMKFEQRLRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK47</accession>
    <name>A0A398CK47_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03083">
        <property type="protein sequence ID" value="RIE03083"/>
        <property type="gene ID" value="D3H35_21105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="230" mass="27839" checksum="DC230F8D5B0596E9" modified="2018-12-05" version="1">MGRGTFFRRLARTDSQQWDEVPFFRRITGTDSQQWDEVPFFRRLARTDTHQWDAVPFFRRLARTDSHQWDAVPFFRRLVGTDAQQWDAVPFFRRLARTDSHQWDAVPFFRRLAGTDSQQWDAVPYFRRITGTDSQQWDQVPFFRRLARTDSHQWDEVPFFRRLAGTDAQQWDEVPFFRRIAGADAQQWDEVPFFRRLARRTLISGTRYHSFDDWRGRTLNSGTRYHSFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK56</accession>
    <name>A0A398CK56_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Urease subunit gamma</fullName>
            <ecNumber evidence="4 5">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Urea amidohydrolase subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ureA</name>
        <name evidence="6" type="ORF">D3H35_21180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4 5">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the urease gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="4 5"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03093">
        <property type="protein sequence ID" value="RIE03093"/>
        <property type="gene ID" value="D3H35_21180"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00739">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012010">
        <property type="entry name" value="Urease_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001223">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="SSF54111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="100" mass="11045" checksum="E2E78A1F338B3673" modified="2018-12-05" version="1">MNLTEREKEKLLITVASDLAHRRLSRGVKLNYPESVALITSAIMEGARDGKTVAELMAYGTTLLSRDQVMEGVPEMIHEVQVEATFPDGTKLVTVHQPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK66</accession>
    <name>A0A398CK66_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-specific adenosine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">tadA</name>
        <name evidence="5" type="ORF">D3H35_23045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01268">
        <property type="protein sequence ID" value="RIE01268"/>
        <property type="gene ID" value="D3H35_23045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00972">
        <property type="entry name" value="tRNA_aden_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="153" mass="16853" checksum="C6658EDB8D4DA546" modified="2018-12-05" version="1">MVLEDDEKWMREAILQAQLAESIGEVPIGAVIVRDGEIVGAGYNLRETSHDPTAHAEMIAIRQASEKLGAWRLLGCTLYVTLEPCPMCAGAILQSRVEKVVYGASDPKAGCVGTLMDLLQDSRFNHRSPWQSGVLHEECGALLSAFFRRLRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK78</accession>
    <name>A0A398CK78_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02755">
        <property type="protein sequence ID" value="RIE02755"/>
        <property type="gene ID" value="D3H35_19115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="127" mass="14373" checksum="E29199002DF08E8E" modified="2018-12-05" version="1">MPATHVWSSEQFRIDPSRPLYEQYIEQIRAMIAKGALAPGIRLPSVRETAAALRVNPTTVMKTYQELERMNLLVTFRGQGTFVTEEAEAIRRSRVALAKHAVRQMEELAASIGLTLHQLLELAKEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKA2</accession>
    <name>A0A398CKA2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17935</name>
        <name evidence="1" type="ORF">D3H35_29305</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000059">
        <property type="protein sequence ID" value="RIE00317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00317">
        <property type="protein sequence ID" value="RIE00317"/>
        <property type="gene ID" value="D3H35_29305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02566">
        <property type="protein sequence ID" value="RIE02566"/>
        <property type="gene ID" value="D3H35_17935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="165" mass="18992" checksum="6BDB085C6F8D1A3B" modified="2018-12-05" version="1">MEENNIGHRKFLKSSRVDYELGTFLPSDVILMREEKPVDLSWLSQTVNGSVMFFLSSYCEVCDAEIVIQTINDFPEYSYAIFFESPNNPVLRHAKLLDERGVKLYPFQLNQLESSIKVQLVPFQLVLNTVGQVITAGIINTLPMIKALMMPLIRTKENNRNEELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKC0</accession>
    <name>A0A398CKC0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">7,8-dihydroneopterin aldolase</fullName>
            <ecNumber evidence="4">4.1.2.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">folB</name>
        <name evidence="6" type="ORF">D3H35_23425</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the DHNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01328">
        <property type="protein sequence ID" value="RIE01328"/>
        <property type="gene ID" value="D3H35_23425"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00534">
        <property type="entry name" value="DHNA_DHNTPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844">
        <property type="entry name" value="PTHR42844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00525">
        <property type="entry name" value="folB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FolB" evidence="5">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="134" mass="14867" checksum="6AAD024E92ECE832" modified="2018-12-05" version="1">MDRMKLKRMVFYGYHGVFPEENKLGQQFFVDLDLRLDLGKAAESDDVNDTVNYAEIHALVKEIVQGPPVKLIEKLAANIAHGVLGTYTSINEATVSVTKPHPPFDITFDGVVVELRRKRNADGSIEAVPAAEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKD1</accession>
    <name>A0A398CKD1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">L-aspartate oxidase</fullName>
            <ecNumber evidence="4 10">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">nadB</name>
        <name evidence="13" type="ORF">D3H35_23475</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the oxidation of L-aspartate to iminoaspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4 10"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01338">
        <property type="protein sequence ID" value="RIE01338"/>
        <property type="gene ID" value="D3H35_23475"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00551">
        <property type="entry name" value="nadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 10" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="11">
        <location>
            <begin position="20"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="12">
        <location>
            <begin position="434"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE01338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="537" mass="60027" checksum="D78F890891780C8B" modified="2018-12-05" version="1">MIPRYVVDFDLDNLPRVDTDVIVIGAGIAGLFTTLKVSETKKVLMITKKSLFDSNTRYAQGGIAAVISEDDSPEFHRQDTLIAGAGLCDSAAVDVLVHEGPQGVQELVRYGTNFDEEDGQFALTKEGAHSQRRILHANGDATGFEIVRALAEKVQNDPAVELWDDHFVIDLLTEDGECRGAIVQKPDGSRVAVFGNAIILCTGGTGQLYRYTTNPEVATGDGVAMAYRAGAIIRDMEFIQFHPTSLCYPGAPRFLISEAVRGEGAYLRNIRGERFMERYHPQLELAPRDVVARAIVSEMEATKSTYVYIDITHESPDMVRHRFPTIYEYCLQYGLDLTTDWIPVAPAAHYMMGGVRTDLYGETNIKRLFACGEASSTGVHGANRLASNSLSEAIVFGQRIVDRINELPKSSRTMKLKIDLERHTLPAGTVIERRLKLQKLMVRYAGLRRDRAGLEKGLEELKRQLPIFQTALTRREELEFINLLTCAVLTTEAALSREESRGAHFREDFPIKNDDEWRKHTTLQREQGVGEEQVNYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKK2</accession>
    <name>A0A398CKK2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_29695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00211">
        <property type="protein sequence ID" value="RIE00211"/>
        <property type="gene ID" value="D3H35_29695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="37"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="354" mass="40130" checksum="16A055FF38BC6270" modified="2018-12-05" version="1">MYVPVPAKISSRRFDFRSLQRLKGGRKIDEVPIVNKVTMKDIAREAKVSPATVSYILNNVENQTITDETRCRVLDTAKKLNYIPSLTARSLAKGKSGMLGLLLNRNAQEGFWKQLYYGTLIERMEKNCKKEGYHLLVSGMEADQPNLDIVQQRKMDGVLLVDVKEGVFRNISVHFSIGTPIVLLDSFIEDSLFHKVVFDYRTAFTKWKERTGDTDNGSFLVMESFNNARMVEEIIKASQMESDSIYVLTSDNADGLKPFLELQRGKKGIVINEFIGALVMNASYGLDLEISVICTSNCPEILPPHVHTFLMDADRCPIDISFQILHFYIQSQTVTKDGAYPQTAYSPYVYIPFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKY2</accession>
    <name>A0A398CKY2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Recombinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_24725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01558">
        <property type="protein sequence ID" value="RIE01558"/>
        <property type="gene ID" value="D3H35_24725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="4"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="3">
        <location>
            <begin position="158"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="369"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="524" mass="59962" checksum="14EA512DBC59E0E8" modified="2018-12-05" version="1">MTMKVAIYTRVSTKEQAEEGFSLDAQRGVLTKFCLDKGYEVVGIYSDEGISGKNKKRPALQKMLKDSASSKFNLVIVWKYSRIARNLVDTLTIVQELKKNDVSFKCLDIDFDTTTPAGIMLMQMMGSIAEYERNNIVENVVLGMNQRARDGKWNGGILFGYNSINKSIQVNPEEAEVVKQMFTWYLNGVGPVLIRDRLNKLGIKTKKGNEFNTIVVRDILTNPVYKGYIRFGRRREHNKLNESYTLVVGEHQAIIDEETFEKAQIVMQSNKRKTKRGTSGVHLLTSILRCPDCGAKMYFHPASAPKPDGTYRGYYMCSRYKQNGTCKARTINAEKTERAVIERLAHFIASQEIVKGVVNELNNNGTMDLSLVKKQLETILREIRELEKGKHKQMLDYSMGKIDVDSFKEIKQFTEKVIKERVEQREALEKELVKSVNNTVNYNAVHNALKKFQTMFQKADMKLKKRLLDSLIEKITLNEDRTIKHIEFRFELPNNNGPDDVESNDVVTSHGTLNRIISRAKAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKY4</accession>
    <name>A0A398CKY4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS3 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_05600</name>
        <name evidence="3" type="ORF">D3H35_18225</name>
        <name evidence="4" type="ORF">D3H35_19630</name>
        <name evidence="5" type="ORF">D3H35_19810</name>
        <name evidence="6" type="ORF">D3H35_20095</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02619">
        <property type="protein sequence ID" value="RIE02619"/>
        <property type="gene ID" value="D3H35_18225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02842">
        <property type="protein sequence ID" value="RIE02842"/>
        <property type="gene ID" value="D3H35_19630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02871">
        <property type="protein sequence ID" value="RIE02871"/>
        <property type="gene ID" value="D3H35_19810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02916">
        <property type="protein sequence ID" value="RIE02916"/>
        <property type="gene ID" value="D3H35_20095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04563">
        <property type="protein sequence ID" value="RIE04563"/>
        <property type="gene ID" value="D3H35_05600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="131"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="309" mass="35880" checksum="7BF4F5A6BA315075" modified="2018-12-05" version="1">MKRGEKTALVLRILDVAESSYYARKKRSHTPNTDAGNRSTDRGRGRPFPGFSLTTTGERVSDEQIREWLLELVEGEEHVYGYKLLAQCLRNECDLILNKKKAHRLCQEIGILQEQRKRKVKHPRRLARNHLITGPNQLWQADIKYGYVAGRERFFFVATIIDVFDRVAVGQYRGHVCEAKHVVQTLVTALRQRVGETGPFPIVRTDNGPQFVSTLFGDTCEAFDITHERIPPRTPNMNAYIESFHSVLEDNLFSKAVFMTFEEAYAALDTYMDFYNNRRMHGSLKRMPPEEFSKWVMQLEDRTPFYRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL25</accession>
    <name>A0A398CL25_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Circularly permuted type 2 ATP-grasp protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01939">
        <property type="protein sequence ID" value="RIE01939"/>
        <property type="gene ID" value="D3H35_14290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025841">
        <property type="entry name" value="CP_ATPgrasp_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016450">
        <property type="entry name" value="UCP005522"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14403">
        <property type="entry name" value="CP_ATPgrasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005522">
        <property type="entry name" value="UCP005522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="484" mass="54992" checksum="F00491798CFF5AF9" modified="2018-12-05" version="1">MEKLNERTAGAPTSPFYDEMFDEKGVRKHYSKADHVLSRMTIEERANRQNRLNSRLLEEGITFTLAQPDQAEALERTIPFDLVPRIIPADEWEIIEQGTRQRVRALNAFIADIYHEQCILKDGLVPRRMVMGNRYFRTEMMRLPVPGGTYITTSGIDLVRDDKGQYFVLEDNLRSPSGFSYVFKSRSIMTHDFPEMYFNYSVRGIDRTLQDFRSALRNLAPNDKGEPVMALLTPGSFNSAYFEHTFLAQQLGLTLVEGRDLVCRDNKIYIRGIDGLRKVDVLYRRIDDDFLDPLSFRPDSMLGVPGLMNAYRFGNITIANAPGTGVADDKAIYTFVPEMIRYYLNERPILNNVPTYLMSRPEEREFVLERLEEMVVKETSLSGGYGMLIGPSSTEWERELFAAKILENPDNYIAQPTVKLSTSPVSVDGHLVSRHIDLRVFALMDGRNVHVLPGGLTRVAMKEGSLVVNSSQGGGCKDTWVLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL66</accession>
    <name>A0A398CL66_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyamine aminopropyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Putrescine aminopropyltransferase</fullName>
            <shortName evidence="3">PAPT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Spermidine synthase</fullName>
            <shortName evidence="3">SPDS</shortName>
            <shortName evidence="3">SPDSY</shortName>
            <ecNumber evidence="3">2.5.1.16</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">speE</name>
        <name evidence="8" type="ORF">D3H35_21795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 6">
            <text>putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer or homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01648">
        <property type="protein sequence ID" value="RIE01648"/>
        <property type="gene ID" value="D3H35_21795"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00248">
        <property type="reaction ID" value="UER00314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="PTHR11558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="1 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="7">
        <location>
            <begin position="2"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-methyl-5'-thioadenosine binding" evidence="3">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="275" mass="31329" checksum="0CEF330797306784" modified="2018-12-05" version="1">MELWYTEKQTDNYGITMKIKQTYVHEQTDFQELAMIETEEWGNMLVLDGMVMTTEKDEFVYHEMVAHVPLFTHPNPEHVLIVGGGDGGVVREALKHPKVKKVVLVDIDGKVIEHSKKYLPSIAGKLEDPRVEVIVNDGFMHIHDHKNTYDVIMADTTEPMGPAVNLFTRGFYQGIYEALKEDGLFVAQTDNPWFKADLIQSVNRDVKEVFPLVRVYAANVPTYPSGLWTFTMGSKKHDPLAVDESAILELDTKYYSPRLHKAAFALPKFVEDLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLA7</accession>
    <name>A0A398CLA7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_20595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03002">
        <property type="protein sequence ID" value="RIE03002"/>
        <property type="gene ID" value="D3H35_20595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="70"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="293" mass="32893" checksum="900374188212BE26" modified="2018-12-05" version="1">MFINWIDRHLKWVFTLPAVLFIVLMVAYPLIYTGRLSFFEWSMSAVTPPKWVGLDNYVALFQDHRFWNALKVTFYHTSVSIVLETVLGVGIAILFSRKFKGGRIVKTVMMLPMVATPVSIALVWLLIYEPSIGFANQALKALGFETQEWLGSVTQVLPSLIAIDVWEWTPFIALIVIAGLASLPTDPYESADVDGASAWQKLRHITLPLLTPTIITAVTLRIIDLLKTFDTIYATTQGGPNFASQTLNILVYDLAFQNFKLGSASALLVIFFLLILAVILLLTSIRKRQEERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLB8</accession>
    <name>A0A398CLB8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03060">
        <property type="protein sequence ID" value="RIE03060"/>
        <property type="gene ID" value="D3H35_20975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="59" mass="6442" checksum="6228D7A95F0E2BD0" modified="2018-12-05" version="1">MPSDSNLVFIIAAFAFGVVLILTKERLPAPMRRGIAITAALFVAFAFFLIVYSFMMAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLQ4</accession>
    <name>A0A398CLQ4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">tatC</name>
        <name evidence="6" type="ORF">D3H35_15470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms a complex with TatA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02149">
        <property type="protein sequence ID" value="RIE02149"/>
        <property type="gene ID" value="D3H35_15470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019820">
        <property type="entry name" value="Sec-indep_translocase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01218">
        <property type="entry name" value="TATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="244" mass="27354" checksum="DE725B09C0C65C74" modified="2018-12-05" version="1">MTQQEELVGHLAELRKRLILISLWFFATLCAGLYVSPRLLLLLKRHSAAASIEWNVFSFTDGLFIYLRCAFLVAALFTLPLVLYQVWAFVRPGLTEREAKGTFAYVPVSFLLFVSGVSFGYFLVFPMMLHFMKAMNESVGAVETYGMDRYFSFLFNVVFPLGVTFEMPIVILFLTRLGLLNPARIRSVRKYAYVGLAIVGSCISPPDLVSHLSVTVPLLLLFELSALISARFSRKWAAAVPTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLX1</accession>
    <name>A0A398CLX1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000038">
        <property type="protein sequence ID" value="RIE03242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03242">
        <property type="protein sequence ID" value="RIE03242"/>
        <property type="gene ID" value="D3H35_12770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="216" mass="23919" checksum="FFDA856423752F21" modified="2018-12-05" version="1">MNSAPALPLHIDAFSPIPIHIQLREQLKCLIGSGFVRIGDNLPPASELAQQLDLNRNTVISVYNQLSKEDYVRIRKGAGTQVIENPRTHEDREMLALIRGVLHNAGGPDFDREQMPVSLLAFRQIRKSLVGETSRILFVEFHPNEYLAHKSEIDVIPKAEVSRTAIDSLTKLTPAELAEKLAEFDMVVTPYAGLKDISELTATSGIKIVAVGDIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM39</accession>
    <name>A0A398CM39_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_26295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00711">
        <property type="protein sequence ID" value="RIE00711"/>
        <property type="gene ID" value="D3H35_26295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="136" mass="15615" checksum="1DBED1E738134D1B" modified="2018-12-05" version="1">MRRAEKGIASMSVIVKGATFEEVYAELQRLTRVPPTSKEPLVRPVSSETSWQTVLRDLILNAKTGADKFAVVNLEAGVGKSSETERIIIDHIEHMRTRNRLRFLIVKQFNEDVYKCAETIKSFKRPRTKSCCMMWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM48</accession>
    <name>A0A398CM48_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exodeoxyribonuclease 7 small subunit</fullName>
            <ecNumber evidence="3">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Exodeoxyribonuclease VII small subunit</fullName>
            <shortName evidence="3">Exonuclease VII small subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">xseB</name>
        <name evidence="5" type="ORF">D3H35_26360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the XseB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00721">
        <property type="protein sequence ID" value="RIE00721"/>
        <property type="gene ID" value="D3H35_26360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00337">
        <property type="entry name" value="Exonuc_7_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34137">
        <property type="entry name" value="PTHR34137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="95" mass="10490" checksum="78D27FC61CEE6316" modified="2018-12-05" version="1">MGKRNEDSRESSAEEAASVSFEQAMERLETIVAKLESGDVPLETAIELFQEGMALSKLCGNKLEQVERRIEMLVEDEAGVSRKPFTPSREDAAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM61</accession>
    <name>A0A398CM61_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translocation-enhancing protein TepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03340">
        <property type="protein sequence ID" value="RIE03340"/>
        <property type="gene ID" value="D3H35_11685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="254" mass="26877" checksum="BB8FAD0080678684" modified="2018-12-05" version="1">MMSDKTTAFPSSDQPNPAAPANPADEARKASAAVTDSIVQLGQTSVPASESNILCLTIIGQVEGHLMLPPQNKTTKYEHLIPQLVAAEQNPKVEGVLIVLNTVGGDVEAGLAIAEMISSLTKPKVTVVLGGGHSIGVPIAVSADYTFIAETATMTIHPIRMNGLVIGVPQTFEYLDKMQERVTRFVTRHSHISEATFKELMFKTGELTRDIGTTVIGSDAVRHGLINAVGGIGEALKELNRRIGTKKSEGGSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMB4</accession>
    <name>A0A398CMB4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01948">
        <property type="protein sequence ID" value="RIE01948"/>
        <property type="gene ID" value="D3H35_14340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="78" mass="9009" checksum="76C563AB9795CC55" modified="2018-12-05" version="1">MEIGWKTNNGLAKPSVMSTSKICSVPYRHESDRTRGRQRLKLESFSSSRWGRFIGFADQKRLSLLTMSLFLSPFLRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMC3</accession>
    <name>A0A398CMC3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_26745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00791">
        <property type="protein sequence ID" value="RIE00791"/>
        <property type="gene ID" value="D3H35_26745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="9"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="158"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="234" mass="26238" checksum="C243A5BF231218BF" modified="2018-12-05" version="1">MADTDSSVRIWIVEDDPDWLRGLKAYLGGQNGISVEFASDSPEEVRHRLESEDGRSAPDVVLMDIMLNDVPEGIALAEETASATGARVIMLTSMEEKEFIFRSFQAGAIDYQIKSNYETLPEAIRQAARREAPISAAAAERMREEFRRLRRLEREFEAHKMRELITPSELQLLELIDQGYSQSQIADRLVVSIRTVKNHINSILKKLRLGGSKDAARQAKEMGLFGSGNGEKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMD9</accession>
    <name>A0A398CMD9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3502 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_16900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02389">
        <property type="protein sequence ID" value="RIE02389"/>
        <property type="gene ID" value="D3H35_16900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022627">
        <property type="entry name" value="DUF3502"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12010">
        <property type="entry name" value="DUF3502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017399473" evidence="2">
        <location>
            <begin position="31"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3502" evidence="3">
        <location>
            <begin position="400"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="529" mass="57939" checksum="2B5B69405AC8664D" modified="2018-12-05" version="1">MLKTSKKFGKSSAIMLATAMSFVLILSACGNDKNKTGGNEASPVPPSSESASPTASESSSPDTKLSDYNLTLFLPGTTPKDEQKVEAEINKYLKDKINATLDLRFVDWGQWDNKMNLAIASRDPMDIIFTAAWNGHAANVAKKAFLALNDPNGPKGNLIEQYGQDITATLPEQFLKGAKIDGLNYGIPSNKELAEQGGIIYRKDIADELGLTDKIEAVKTIADLEPILAEVKAKKPDMIPVFMRDGENFNAHYFSKFDYLGDNTIDGVVMKDGTDTTVLARYDQPRYKETLAITRDFFKKGYINKDAATTQLGVNDAMKKGNVFMVPSPLKPGKDAELANATNLAGKLKQVAMTERTVATSDTAGAMLGISSTSGNPERAMMFINLLHSDKYLNNLINFGIEGDHYTRSGEIITPNDNTGNYSIGAAWMLGSQFLNYVWNTEASDKWEQFKAFNTDAHNSPALGFTFNAVPVKSQASIMNNIRKQYDPGLDTGSIDPSKAEEYYKKLKANGLDDVVKEKQAQLNKFLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMW6</accession>
    <name>A0A398CMW6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_11125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03580">
        <property type="protein sequence ID" value="RIE03580"/>
        <property type="gene ID" value="D3H35_11125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="64" mass="6998" checksum="C4C6FDACD7F8D16E" modified="2018-12-05" version="1">MWKLNSHASAGYVSGMRVWKLNSRASNGYVSGKKGQRSAKGRLPVVVVYFVSIQTDDAVSFFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNA1</accession>
    <name>A0A398CNA1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03782">
        <property type="protein sequence ID" value="RIE03782"/>
        <property type="gene ID" value="D3H35_09520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039498">
        <property type="entry name" value="NTP_transf_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14907">
        <property type="entry name" value="NTP_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="346" mass="40720" checksum="3A2E95CE8686C329" modified="2018-12-05" version="1">MIQIVSTRRSEGGAGLVATLLRFLYDKETPAPHNEAVYRGFLEEIELFGIASQVLTALQQSGKTDQVPEDFVRRLKRYAEPGRFRNIRIQWFERQLFRIFEQANIPVVPLKGIQFAANYFGHFTARSTGDIDLLVRPEQLQDAIEWLKAFGYRHEETIHNHAVLRKAVDGAPLVELHWTLDKPGWSELDPEPFWRDSAPLGQFRFVRELSVTHTFYAICLHGVRHRMESLRYLLDIAQMLYRFGSSIDYAELFAQAAADRTVNRLKAALSIVYRVFPKLDQLKPLPFEPRRTLWSYPAIRDARLRVKSVRYYKYRLYFKLFIFDTWKHGWHARRRITSKYSEYSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNF3</accession>
    <name>A0A398CNF3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01447">
        <property type="protein sequence ID" value="RIE01447"/>
        <property type="gene ID" value="D3H35_24105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="228" mass="25000" checksum="170AB73FCF25DB24" modified="2018-12-05" version="1">MYIEANPYMYPYNGELRADNTALIVIDMQIDFCGKGGYVDRMGYDLSLTRRAIEPIGRLLEITRAIPGFTIIHTREGHRPDLSDLPANKRWRSKQIGAEIGSAGPTGRILVRGEPGWHIIEELAPLPGEIVIDKPGKGSFYATDLDLILRTKGIQNIILTGITTDVCVHTTMREANDRGYECLILEDCTGATDHGNHEAALKMVTMQGGVFGSVSDSIKASETLGRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNM2</accession>
    <name>A0A398CNM2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation protein YqfC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yqfC</name>
        <name evidence="1" type="ORF">D3H35_06170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04203">
        <property type="protein sequence ID" value="RIE04203"/>
        <property type="gene ID" value="D3H35_06170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022476">
        <property type="entry name" value="Spore_YabP/YqfC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022477">
        <property type="entry name" value="Spore_YqfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07873">
        <property type="entry name" value="YabP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02856">
        <property type="entry name" value="spore_yqfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="93" mass="10280" checksum="EDA4798DA274E533" modified="2018-12-05" version="1">MPPVSRKLRKWAAAILDLPQDVVLDLPRVTMIAGLQITVENHRGVVHFSSDSLRLAMDRGEMEVTGSNLVLRHIGADDCLVEGQIAGFRLHPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNU4</accession>
    <name>A0A398CNU4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01241">
        <property type="protein sequence ID" value="RIE01241"/>
        <property type="gene ID" value="D3H35_22880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="249" mass="28300" checksum="5A8878F12C465E4C" modified="2018-12-05" version="1">MKKPNADWERELLETPLGMNGFTDLMVKKIKGRVDMANKKKNRFSQVGVVAAAVALLGSAWLLREPLADIARGKQANAPASAHEWQDEEIRLSIQYFNKNSFMFEFGNRFAVLHPKVQFDIPPEPESYELEEYKQWLVKNKPDIVQVPLNLLKPLADEGLLLPLDERIQRDGFALEAFHAPVIQTIREAGAGKLYGFAPYFDTAALYYNRTLFERNGVKLPTDRMSWEDVLRLASRFGGRPKTASPYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP57</accession>
    <name>A0A398CP57_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_26255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00704">
        <property type="protein sequence ID" value="RIE00704"/>
        <property type="gene ID" value="D3H35_26255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="71"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="276" mass="31281" checksum="263A1F705D6CE68A" modified="2018-12-05" version="1">MTQRQKRIQLIALEIVIAIVALLFLYPLFLVVFNSFKTYEQVLTNIMALPKSLITINYSEVWRLMEYPTLFVNTFLLTLVSVAGIVFIGSMAGYKLSRTKPRWSAFLFFVCISPMMLPFQSFMITLTKLSKQLHLINSLEGLSVIYWGLGAPLAVFMFHGFVKSLPLELEESGAIDGASSYGVFFRIVFPVMVPVISTVIILNVMWIWNDFLLPLIMLNGKQSTLQLASYKFFGQYKSEWQYALTAVVYTSIPPVVVFLFLQKYIIKGMVAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP71</accession>
    <name>A0A398CP71_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">nusB</name>
        <name evidence="8" type="ORF">D3H35_26375</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NusB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00724">
        <property type="protein sequence ID" value="RIE00724"/>
        <property type="gene ID" value="D3H35_26375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusB" evidence="7">
        <location>
            <begin position="6"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="152" mass="17206" checksum="7E08D93F3B9DCE3E" modified="2018-12-05" version="1">MKRRLAREITVQSLYQIEMNGVTGEIAVDNVIEDARQDNEVGTEVSELASIDAFTRGLVEGVESNKEEIDKALAEYLTGWQVDRLSRVDRQILRLAAYEIMYCDDVPSKVAINEAIEVAKHFGTEESGKFVNGVLGRMVREREAKQRKETEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPA6</accession>
    <name>A0A398CPA6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05236">
        <property type="protein sequence ID" value="RIE05236"/>
        <property type="gene ID" value="D3H35_01565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016786">
        <property type="entry name" value="YdeI_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021308">
        <property type="entry name" value="UCP021308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="20"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="197" mass="23197" checksum="04D00DAEE4E76086" modified="2018-12-05" version="1">MTKGERNPKIDPFFRKEKKWKEEFEKLRDIVLDCELTEDFKWMHPCYTYQNNNIVLIHGFKEYCALLFHKGALLKDPHGILIQQTENVQAARQIRFTNVQEIDEMQLILKTYIDEAIEVEKAGLKVEFKKNTDYAVPEELQNKFAEIPDLKTAFEALTPGRQRAYILHFAQPKQSKTREARVEKYLPHILNGKGLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPJ6</accession>
    <name>A0A398CPJ6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_12810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000038">
        <property type="protein sequence ID" value="RIE03249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03249">
        <property type="protein sequence ID" value="RIE03249"/>
        <property type="gene ID" value="D3H35_12810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="3">
        <location>
            <begin position="12"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="476"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="631" mass="71195" checksum="95032B3B8B4F3941" modified="2018-12-05" version="1">MDETVKEASVKALTAGQRALWILSRLAPESSAYQTSRAIRVRGTLDSRKLLRVYERLSIAKPSLRTELVERDGAPLLSLNASANIRAETLDVTGWSELELAERINQEANRPFELGGEPLFRILLLRRADDDTVLVATAHQLLLDPDSYFAVLEELLSGYGNEEKLWTEANEPELQPDRVDRRDEDAARAYWLQKLSGTLPVLHLPADKPRPPVRTFGGSDLSFRIPDGLAQSLRKAAANERLELQELLLAAYQVLLHRYSNQDDVLVGVFLPPHDDAQEASIGSYANPVVVRSDLSEDTAFADFFRKTGTALAEAYERRGFPFPQLVELLQPDRDPSFPALFQASYSYRKQQGRYAAGFGALAFENEGKEFDFADGLTFESIRLARKEVQYDLRLSVIDDGEAAIGRFDYYSDLFEAGTIERLKDNFLTLLESIALQPEEQAKRLNLLAEGERELLLGDWSGEAKAFPEVAIHSLFEERAALHPDKEAVVFGEERWTYRELNERANRLAHYLRKNGVVPDTLVGVFLERTLDIPVVLFAILKAGGAYVPLDPHYPKDRIAVTLEDSRAPIIVTRSDLASLLPADYEGKIVRYDEEQDVISRNRRSIRREGRSRAIWLTSSTRRARPDGRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPV4</accession>
    <name>A0A398CPV4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">M20/M25/M40 family metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_05610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04565">
        <property type="protein sequence ID" value="RIE04565"/>
        <property type="gene ID" value="D3H35_05610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010162">
        <property type="entry name" value="PepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42994:SF2">
        <property type="entry name" value="PTHR42994:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01883">
        <property type="entry name" value="PepT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="6">
        <location>
            <begin position="183"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="377" mass="40243" checksum="73BAA298A075F531" modified="2018-12-05" version="1">MVQKERLIAEFMELVQIDSVTKHEQVISKVLREKFESCGLEVTEDDVGPKIGHGAGNLFAWLPASAGLESVTPILFTSHMDTVSPGNGIKPTLHEDGYIRSDGTTILGADDKAGLAAMFESLRVIEERNIPHGPIQFVITVGEESGLLGSRFMDGSRLKAKLGYALDSNGSIGDIAVAAPTNARMYITIKGKAAHAGVNPEDGISAIQVASKAVSRMKLGRIDHETTANIGRFEGGGEVNIVTDQIKIFAEARSRVQEKMDKQVEAMREAVEGAASEHGATVEFVNEVIYPAYQYGDGDEVVEIAKAAITAIGCTPKLFESGGGSDANMFNGNGIPTVNLAVGYEDIHTTSERIKADDIVKVTELVVAIVSETVKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ72</accession>
    <name>A0A398CQ72_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Segregation and condensation protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">scpB</name>
        <name evidence="5" type="ORF">D3H35_03660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Homodimerization may be required to stabilize the binding of ScpA to the Smc head domains. Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ScpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04602">
        <property type="protein sequence ID" value="RIE04602"/>
        <property type="gene ID" value="D3H35_03660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01804">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019345">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="205" mass="23003" checksum="5ED3798808E29EF8" modified="2018-12-05" version="1">MDYSTLKSVIEGLLFVSGDEGLSSKGIAEVVEMNPEVVRDVIIDLQQDFVRDNRGVRVSEVAGGFRLTTVVEHAPYFEKLAYSPSRSSLSQAALETLSIVAYRQPITRVEIEEIRGVKCERPLHSLVNKDLIEEVGRADALGRPILYGTTKSFLDYFGLAGLNQLPDPVIPEGDDELEERTKLLFERIEGRQLSMEDMERELETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQC6</accession>
    <name>A0A398CQC6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_04360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04723">
        <property type="protein sequence ID" value="RIE04723"/>
        <property type="gene ID" value="D3H35_04360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011623">
        <property type="entry name" value="7TMR_DISM_rcpt_extracell_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07695">
        <property type="entry name" value="7TMR-DISM_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="469"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="693" mass="78348" checksum="71957EC0939DE2B3" modified="2018-12-05" version="1">MHRYNGVRMGAVLLHRWLLLVMAFGILLTGCSFKEEPRSYPKAQNGRLDLTDWSWEKGGIMPLDGEWSFEWHESRSADAREMKIEVPGMWGAMRDDRHPGLKDQGFGIYRLTLVHLPTYEIMAIRLPNISTAYSLIINGYRVMTKGIPGMEAEETIPSQKPEIVFYMTKGRQTDIEIRVANFDHRNGGIRTPIILGKAKQIEKLQASHSRMEFIVFGSLCMIGIYHLGLYLLRRKEGTNLFLALLCLFVALRAGLIGEGVIVQWFPFIDWQIATKLEYIAFAAAGWSGFAFLGHMFPREFGKRWLQASNALVLSLSVFTAVLPTLWFTSCLVVFQLYALVFGLRALIGLIASTFRNREGAKLALIGMAGFLLTIVNDILFYNGWWRSLDLVPFGLLFLIVMNAFIISIRSSRTFERAEHLSAELKEWNDRLEGRIAERTEELRHSYMTLEEAKIGLERMEQSRRHLVSNISHDLRTPITLLQGYLEALRDGVIDEPERRDATIRLMLGKVEGLGRLIQDLFELSVLEARRVELSLETITLGEWTERLAEQYGLEMPESEVDFRCETASLDAASATVSVDVHRMDRVFANLIYNAVRYTPKGGTIAVKFDMEEDGSHALISLSDNGSGIHPDDLPHIFDRFYKKDKSRHSSSGGSGLGLSITKEIVELHGGVITVVNLPEGGSEFRIRLPIAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQJ6</accession>
    <name>A0A398CQJ6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_04865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04803">
        <property type="protein sequence ID" value="RIE04803"/>
        <property type="gene ID" value="D3H35_04865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016625">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011894">
        <property type="entry name" value="PorC_KorC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02175">
        <property type="entry name" value="PorC_KorC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="248"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="286"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="335" mass="36719" checksum="B8B71B131F24B022" modified="2018-12-05" version="1">MTMLPKVNELGFFEIRLESIGGLGANLAGKMLAEAGVMGVGLNGVSFSSYGSEKKGSPVKAHIRFCDLNALIRDTSPVERPHVIGVFHENLSKTTNVVSGMYEDSIVLVNSKKMPETLKEQLKLKGGTIAVVDATGISMAENNRVNMAMLGGLFRLCGFLDPEFMKGVIRKSLEKKYPGAVQPALNTFQRGYDEMRVQTFELPSGDEMPAYVRMDTPVLGYETQPLGGTITNPGNSILKDLSISRAGMMPHFADDKCIHCAACDNVCPDFCFVWEEQPDKKGRPQMFLQGIDYQYCKGCLKCVQACPTEALASEYEEEGYAETNRVAHKFNLAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQN0</accession>
    <name>A0A398CQN0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02127">
        <property type="protein sequence ID" value="RIE02127"/>
        <property type="gene ID" value="D3H35_15325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="65" mass="6967" checksum="DE238C68395C505E" modified="2018-12-05" version="1">MVGLLGEIAYECEPQPNVVGLSGGIAYECEPQPNVVGLSSGIAYEREPQPNVVGLFGEKAYERKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQN4</accession>
    <name>A0A398CQN4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_11115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03579">
        <property type="protein sequence ID" value="RIE03579"/>
        <property type="gene ID" value="D3H35_11115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="143" mass="16322" checksum="2DE423EDDF802548" modified="2018-12-05" version="1">MGYCGNNYTFCPGSYVLKVGKITFKSGEEATSYYNKLKKTQDITWSPYKNKHTLDSKVKWDKKAIQSTKLVQRSISLGSKRMLERITWDQGKIVKDSNGSTWKILEFDDIVGAYLGKETKYVVVKESGGKYIHPISEEEAKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQR5</accession>
    <name>A0A398CQR5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_05320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04883">
        <property type="protein sequence ID" value="RIE04883"/>
        <property type="gene ID" value="D3H35_05320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="59" mass="6860" checksum="05A2D0352433D32F" modified="2018-12-05" version="1">MVGADIGLDNHLRPWIIELNTNPDPYIFRHLADKRIARKVLSYARALRRIPPAKSKPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR70</accession>
    <name>A0A398CR70_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagellar hook capping protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_11400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FlgD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03288">
        <property type="protein sequence ID" value="RIE03288"/>
        <property type="gene ID" value="D3H35_11400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005648">
        <property type="entry name" value="FlgD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03963">
        <property type="entry name" value="FlgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="158" mass="16855" checksum="46DDE8EABDEA9124" modified="2018-12-05" version="1">MANEAVGTTNIWPYYSAQNVQKAARTPTKELGKDEFLQILIAQLRNQDPMQPLEDKEFISQMAQFSSLEQTANMASELKSLRQSAGIASGIIGMQVSWIATSNTGTVEAKNGIVDSIVMRDGIQYAKIGQSEVKIDELTSIALPSVSGGSGSGVAASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR72</accession>
    <name>A0A398CR72_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_09385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03759">
        <property type="protein sequence ID" value="RIE03759"/>
        <property type="gene ID" value="D3H35_09385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="3">
        <location>
            <begin position="28"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="2">
        <location>
            <begin position="179"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="264" mass="29030" checksum="E0FA303FFEC23F6A" modified="2018-12-05" version="1">MEKRRGNGERLVCASFAVGFRVVGLSPTVVVSHGWGSNRSRVLRYVHPLHREGYSVLVYNVRSHGDSDSVKAPSGLLFRDDLQSALRYLEGREDVDKQRIGVLGHSLGGFGAVLALDEGAPIRALVTDSMPVRFATMVEAELRRRKLPAFPLAHIIPEIMVRRSRIPSALVKRANPAAILEDNASGKRVPVMLVHSRGDSIIPPAELNHVLARVPDANHLFVDVDGHSASEQDPAFWPAVTGFFKEYLSIREEAVDKQGDYASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRP8</accession>
    <name>A0A398CRP8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05232">
        <property type="protein sequence ID" value="RIE05232"/>
        <property type="gene ID" value="D3H35_01545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017202457" evidence="1">
        <location>
            <begin position="26"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="444" mass="49654" checksum="B61469A04BEB8D5F" modified="2018-12-05" version="1">MVRKLAAVVGGLVLLLASACMKEKPEETSLKKTIKVMFSSESDFNQKYGQYFAAEYPNIEIEVIPMGLVTSEQKWQLIQQQKPDVFFTYMNEFEFLVKNNALVSLEPFLKENSFDLGSLHPGLISALRERGGGQLFALPLTFNSIALIYNKQLFDRYKLEYPRDGMTWTEVMSLAKKFPTDGPEESRVYGLSVGSSYSDNLVELIRYIGQTKGLAYWNAEGDQVTLNTEAWRRIYFEAVELFRSGAIKRTQLSAGVQSANENEFAKGNTAMTLDSYYSVATGLLQASGRAPDQQIKWGIAASPVSDKDGETGIYFASDELTVISAESAQTKEAWAFVQYVNSEEYARIKNQLLPIPPLLARTGSMREFDGNQLDKFAQFKPNSLNYVASDPLKNAFYNVFEKIASGKLDEVLAGKLTVEEAVEQLQVLGQEELMKVRSAAAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRZ7</accession>
    <name>A0A398CRZ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000009">
        <property type="protein sequence ID" value="RIE05323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05323">
        <property type="protein sequence ID" value="RIE05323"/>
        <property type="gene ID" value="D3H35_01060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="28"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="335" mass="37445" checksum="C70CFF3FA6A1D3DD" modified="2018-12-05" version="1">MSDLSPIWTEHAHGWLQVKIPLPFSLKWVNSYLLPGDAGWTMIDPGLRTEEAIACWDSVLDQVGIDWSGISSIVVTHHHPDHYGLAGLAQMRSGAPIWMSQTAMKTARRLWGKDETFSAELTEAFVKHGLPSELEQSMLEHMTGFRRRCRLGPERPDIRILEPGTEFKMAGAIWEIIGGEGHAPGHVSLLDRRRRLLLCGDQVLPQITPNIGWMPGGDPDPLGSYLQTLRSMLGLPVDIAFPGHRDPFSRFDERVLEIAAHHDRRLSHMLELVGDGSISTFELCEATFGARLRGNIHNLRFALAETIAHAVYLEKSGKLIRAADFDGSIIRFRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS21</accession>
    <name>A0A398CS21_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03538">
        <property type="protein sequence ID" value="RIE03538"/>
        <property type="gene ID" value="D3H35_10845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="246" mass="27186" checksum="3E1B5ED087AE3CDA" modified="2018-12-05" version="1">MNKREIRLYMLAGVATASHFLDGFRLTIHRLIEESGLDVRSKLLFPYGDWGRSLVPQLREVGRDIRGREGRYFRSIGANRALAAIDADRIDSEASVHVTNILVGHSAGGIAAVQAAQLLLERDGGTPCPVAMIGSPKCRIPAGLRESVLYVYASPPVMDGRAYVKPTDPVCRIGSFGGWTTDGRRLPAWRMDRHAPASFRGVSIAGGHPDYFRDRPPYLNEMGMTNLEITTDAVWPWLLERIESAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS42</accession>
    <name>A0A398CS42_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02617">
        <property type="protein sequence ID" value="RIE02617"/>
        <property type="gene ID" value="D3H35_18215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="111" mass="12466" checksum="C1548582E6EFAB88" modified="2018-12-05" version="1">MTIKYRIACPGSDIYVLEKEDGFHLTVSSRTNPLSFGSKVAAFHSLGNAVEAAESFHVVFTLSKEYGYHLDQNQLKKDGLQALSVLELLESPRSSTDLRDMFEREKAVVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS90</accession>
    <name>A0A398CS90_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_13550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01814">
        <property type="protein sequence ID" value="RIE01814"/>
        <property type="gene ID" value="D3H35_13550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="318" mass="35277" checksum="0C00990CD3D0449A" modified="2018-12-05" version="1">MNVIEAYRGELELVFEEAAAEIASFPAHLSEFGLKLLARANPLSNGGGTNSISYLLPYWMKEQTSGSDVLCRDLSVGNIFAMLHFFLLDDAMDTDPVTAEKGWIRSSLALGQLLQARFQQRYSRHFSADSELWAYYRAYVENWASAVSLEGRQPADPRDPARLARKSAPVKLCAAGMLLLSDGQERIRTTEEAIDLALATLQLSDDWADWRDDLADENCSAFLTLARERLSASQDVPLDERTVKQAIYRYGCLDALADIVEGYGRRLKELPDVPPKVTAFHDSIAAGIREDARAAEEWTTNLALNGGFSVILLNHSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSE0</accession>
    <name>A0A398CSE0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">rsfS</name>
        <name evidence="3" type="ORF">D3H35_05905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04159">
        <property type="protein sequence ID" value="RIE04159"/>
        <property type="gene ID" value="D3H35_05905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="114" mass="12881" checksum="66B758519E415A01" modified="2018-12-05" version="1">MAETAEKLLKTVIDGAEDKKANEVVALNLKGISLVADYFVICHGNSDTQVQSIATEIRKRADELGVRVRLEGMDTARWVLIDMGDVVAHVFHRDEREYYHLERLWSDAKVVTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSQ7</accession>
    <name>A0A398CSQ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05190">
        <property type="protein sequence ID" value="RIE05190"/>
        <property type="gene ID" value="D3H35_02130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="238" mass="26532" checksum="FE3B142C526FA825" modified="2018-12-05" version="1">MILRVLSSEFLKIRKKLIWFLVVLGPFGVVGLQAVNFGLRYEYLVKGQYKDELWSGLIENVSLLMLPAMFIGLAILASMTAGIEHQMNAWKMTLALPVRKTDVFAGKLLLTLALLFVSCSLLIPFTAALGWALGFRMNVPWELMLLNAYVPFVAALPLVALQTWLSVSLHNQALPLTLGIFGTVASMFAERFPDWVPWKWPVMTATPDDRLYALSAGLVLGAVLFLVGMNEFVRKDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSR8</accession>
    <name>A0A398CSR8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_19715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02857">
        <property type="protein sequence ID" value="RIE02857"/>
        <property type="gene ID" value="D3H35_19715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="30"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="202"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="395" mass="45295" checksum="7D1A012DCA59D41A" modified="2018-12-05" version="1">MRGERERAMLKVAFVTPGAYAVPSAMGGSVERVVEKVVPLLVPRVDARIYGRTARRLPKQERWRGVRCERFPAASKSAYFRRVCRRLRAFRPHIIQVENRPLWVPKLKRLFPDSRIWLNLHSTTFISRPYLSAEARSRCLSSADRIVVNSHFLKDVISGLVPRTAARIRVNHLGVDLERFSERSEPEDDEQRSSDLRKGRWNNRKVVLYVGRLVPQKGVHHLLGAMKDIVREHPDVLVVIVGGARYGSKRGSAYVEKLKRMARPWEKHVHFEPYAPHDQIHRWYEKADVAVVPSVGKEAFGLVNVEAMASRLPVVATAAGGIKEVVADGETGFLISARKEEIRKQLADKVDGLLKDEELRIKMGKCGRERVERLFTWQRTSDRWIELAKEGMHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSS7</accession>
    <name>A0A398CSS7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02867">
        <property type="protein sequence ID" value="RIE02867"/>
        <property type="gene ID" value="D3H35_19785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="61" mass="7007" checksum="E78771BC28D81FC6" modified="2018-12-05" version="1">MKIELLQDLKPAGKTKNQRFIKEPLFHRQHSIQLLMFPVSGENIDTMAMIAKGSFTLTHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSV4</accession>
    <name>A0A398CSV4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Copper amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_14870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02044">
        <property type="protein sequence ID" value="RIE02044"/>
        <property type="gene ID" value="D3H35_14870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017336609" evidence="1">
        <location>
            <begin position="21"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="NAGPA" evidence="3">
        <location>
            <begin position="216"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="2">
        <location>
            <begin position="759"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="2">
        <location>
            <begin position="786"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="878" mass="92127" checksum="E826D5FB4EAA43DF" modified="2018-12-05" version="1">MLATSVPLNAGWLAVPVAHAADAKAATVTYKLVKQSEAIVTSGVKQINYAWTPSVAAKTTEMLHVLQIDLTNKYVNLNAMAGKAGSVTTGQSVTAMAKETGAVAGVNGDVFNTATEGAPMGAQIESGKLVVSTSQLKGMYAFALTKDKKPVIDLFTFQGTVTAAGGATFALAGMNKSAYKTEPDKAYSHVDALYMYTSDWTASERPTASATKATEALVVNGVVTEVSASGTPIATPIPENGYILRGHGKAAAFITGSLKAGDKVTSTYTLKSQTTGESYKESDFQMMVGGHTILLDQGKAAAFSRDINGVSGSADRARTAVGYSKDGKTAYLVTVEENGGREGVTLKELQQMLLQLGVWKAVNLDGGGSTTMVSRPLGEYTASLTHPTSYGTTQRLVSNGIGVYTTAPKGTIKGITATSGATTLFIGQQTTFQVKAYDSYYNPVDKLGFEATWKISGGIGTFKDGVLTAAKAGKATVSVKAGTASSEVGVEVIGASQIERLTVDSGSVILRPGAVISVPVKARLKDGREISVPASSLQWEFKGFEAKASGGKLTVTSVEPGITAGYAIARYDGLGTAAILAPGSEKVLADFEDAATPVSFSALPAETTGTASIIGGVPGRETSNVLSLYYDFTYGKGSRFAYANLLGADGKGIAIDGNPSALTLDVLGDSSFNWIRGEFVDSKGKQVLVDIARTIDWSGWKSIKVDLTKASLTTPARLTKLYVVNLEQDQDERALQGELAFDNVAIQYPPAAYVPVKPTIVLGVGKKQATLNGKTIELTTAPFTVNGVNYLPLRFVADALGAQVFWDNAARRVTVLREDSIIELWVGNSEITANGVRKKVIAAPINKNGSVYVPVRVISEQLGQTVGWEPKTKTITIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTB6</accession>
    <name>A0A398CTB6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05400">
        <property type="protein sequence ID" value="RIE05400"/>
        <property type="gene ID" value="D3H35_00845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="314" mass="34055" checksum="FC2CB7FB26BAA555" modified="2018-12-05" version="1">MEIAVRPTVHRAFGLRISSRIPLPELPLSGDGTERETADIVVETADPVRLREELEACGSNFAFARQGSRFLFLIPGTAVYSIEEGRRIAVAPLPGADREKVRVYLLGTCLGALLMIRGMLPLHGSAVVIDGKAYAFLGESGAGKSTLAAAFVRMGHRLASDDVVAVGLADGKPVVLPSYPQQKLWRESLEGLGMETGPYRPIFRETGKFAVPVASRFSSEPVPLAGAFELSKSDRGTIGVRQLNNLDRLRVMLQHTYRNTLIPRLGLEDWHFRTAAGIAAQIEVCRLQRPSEGFTAGQLAEAIIHFARGGERGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTF0</accession>
    <name>A0A398CTF0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LPXTG cell wall anchor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_05450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04539">
        <property type="protein sequence ID" value="RIE04539"/>
        <property type="gene ID" value="D3H35_05450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033764">
        <property type="entry name" value="Sdr_B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01345">
        <property type="entry name" value="DUF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17210">
        <property type="entry name" value="SdrD_B"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01451">
        <property type="entry name" value="B_ant_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017241453" evidence="4">
        <location>
            <begin position="31"/>
            <end position="2600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2576"/>
            <end position="2594"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="5">
        <location>
            <begin position="183"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="6">
        <location>
            <begin position="863"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="6">
        <location>
            <begin position="1004"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="6">
        <location>
            <begin position="1133"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="6">
        <location>
            <begin position="1257"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="6">
        <location>
            <begin position="1380"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="6">
        <location>
            <begin position="1513"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="6">
        <location>
            <begin position="1641"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="6">
        <location>
            <begin position="1759"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="6">
        <location>
            <begin position="1880"/>
            <end position="2000"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="6">
        <location>
            <begin position="2005"/>
            <end position="2125"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="6">
        <location>
            <begin position="2130"/>
            <end position="2243"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="6">
        <location>
            <begin position="2253"/>
            <end position="2367"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="6">
        <location>
            <begin position="2372"/>
            <end position="2487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1962"/>
            <end position="1984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2331"/>
            <end position="2352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2494"/>
            <end position="2571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2519"/>
            <end position="2556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="2600" mass="273352" checksum="242E024A205CD43E" modified="2018-12-05" version="1">MKLLKSLGIVILSVALLWNFSWLPKPVANADGTNGVILEPFTVSKTTVKAGEVFTYRIAFSFSALLDGADFTKLKVELTLPDGVEFDDYLASSVVAGYTKTGRTYSFNFKTGADAPRSGSSYTIELNAHFPNHDTPNNTTTTPTHFAVVQYDGAPVTLETSNDVTVTSEAIAKWALTKKHVSPEPTPMIGDKVQYEIFFNNEQSSDTRGVVDIENVVLTDVLPAEAVFISASAGGVHSGEPTGGTVTWSPGKLSDDQRYYVTVAYPLGSVVDPDHDEVTNLAAAVFNPLGTDPIADKVSLAAVYKHGFTTLPQDLGPGGMMNKWVHEREREISPDQDVHFYIGGLRNRSNGELTGASIVDMTPPDLILKSIDTAKFEYEGHSYEVYYESASDPGNWQLWDGNVSSDTSKLLEVSDLPGGTVVSGVKFVFPDPLLISFRQSSNFQLTYKLRPDFPDAMSGQVRTNTATLEYTFDGTTVSHPYTANVRLWGIRPLVRIDKSVVSDGPYQPMKDKNIVEYEIAVSNSDYTTMPFYDPIVVDVLPKELEYVDTSWTVSSNTGFSGNDKLIMDPPVVQGDGTTKLLWKFSSLATLNKNDKFVIRFKAKLKDYTAPTADNHELENVAYLTTNNALNPYINDYYFDPLIADADDLDGDGQFNDKMIDSKAYVKVNKVAQLDSVKQVRGELDNDWQVGDLAHLANTTEGGRVDYKLTVRNGSNIPVKNISVVDVLPRVGDQGVLVSDARQSTWSTVLTAPIPDVAGVYTVYYNTGASVKMTTPGGWTATPPADLTTVTAIKFLFDAAYQLSPGASYDIIWTMIAPVGTDQDEIAWNSFAHQATEIDGSSIAAAEPPKVGVHVQNIPANKGSLGNYVWVDLDKDGTQNEGAEWGLNGVRAELYEADGVTPVQKFGINVFTVTGDDIDGNPGYYMFPNLDFPHSYKVKLIVPTSLPSGYTANTFTGWTDKSKAGSTPINDSDVVPASGLTDVIALNSHTPDLKWDAGLLPPLGSIGDYVWHDVNGNGLQSDDAADKGINGVQVKLEKEIAGSWVYQTTQTTADKGGNPGYYEFAGLLPGKYRVLFPDKLADGKILTKKQQGGNAAIDSNPYNNTSSSHGYTDAITLRLGEIVDTIDAGYAAPASIGNYAWSDLNDNGLQDAGEPGIASVKASLLDSSNNPIKRNGINYELSTDASGSYLFEDLLPGTYKVKFDLPTGGYAYARQDAAGGTDAVDSDASRTNGRTGSYTLAAGDSNLTVDAGYVKLVKLGDYVWMDKNRNGQQDAGESGVPNVTVNLYNDEVSTTTAAATTATDANGNYEFANLVPGKYSVEFVRPNGYLFTSKGTVPAATNDSNANVPAAASTAKAKTDQITLLPAIDNLSIDAGLIELASVGDFVWHDSNDNGLRDVGETGIAGATVQLLDSDGDPVAADAYGQAISILSTGADGKYLFDHLLPGDYQVKFTLPTGYWFAKLNEGADDSIDSDAVKQPSGDPGDPAEGVAAVTLAAGDHNMTVDAGALSLARLGDFVWHDKDGNGIQNAGESGVASVKVELLKADGTPVTIDAYGNGISPVLTAANGSYAFINLLPGDYKVKFSELPAGYVFTTSGQGTSATDSDANPAAGANLGVTSPVHLDWGETNNTIDAGIVNRAALGDFVWYDSDGDGVQDAGEPGIVNVNISLYKSSDLTTALASTLTGADGKYSFTNLWPGDYIVKFSLPSDYYIFSPRLSGGNVALDSDANPASGNSGVVTLQSGDNDIGVDAGIVELVSIGDLLWDDTDDDGVQDAGEIGYGGVKVHLLNGTGTPILNGGAAVTATTDANGNYLFDKLNPGSYQVRFELPAGYMFAKKNSAGGTAATDSDVNPATGTTDTLVLAPGAHRIDVDAGIVKLASLGDHVWMDRNLNGIQDGGESGVGGVTIRLLDAAGNPVQSGGADVTTTTNGDGDYTFANLVPAAYKVKFNLPAGYVFTQKGAGTSATDSDADPTTGANQGVSSAVTLAPGDNDANTDAGLIKLVNLGDVLWVDTGIIGAQEGEATNAAASGVLVSLYDGSGSPVLSGGIPVTTTTAADGSYLFTGLFPGAYKVKFDLPSGYLFTRKHVTGAGITTASDSDVDASGWTDAVTLTAGDDNLTVDAGIVLPAALGDYVWNDSNQNGIQDAGESGRNGVKVELYDANGALLQTATTADNAGAPGYYSFANLLPGTYKVKFKAPSGYMFTVKRAGANQAIDSDAGYTGESDPVTLSPGENNLNIDAGVHLVPPIPPATLGNYVWIDSNADGIQDSGEKGLNGVTIELYNRFGALVLTKTTANDKDGRPGYYLFESIQADDYSVKFILPSGYVFSPSKKGADGETDSDAGENGATGTITLQPGQVNLSVDAGLTPLSSIGNFVWIDADNNGKQDVGEKGQNGISVSLLDESGARIASVLTDNDSNGQPGYYEFKNLLPGNYRIEFELPIGYVFSKLNAAGTNSDNDSNAGENGLTGLVTLAPGARDLTIDAGLVFEKVEPVEPPVKEVDGNNGTGGGKPAGSGGSKGGNSGSKGNANGAATGGQSEGKANVAGDSDSNEGRSNVKGVGDGKSLPQTGEEAPIYPYFGYGLILSALALLIARKKIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTG6</accession>
    <name>A0A398CTG6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_16095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02254">
        <property type="protein sequence ID" value="RIE02254"/>
        <property type="gene ID" value="D3H35_16095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="303" mass="34185" checksum="78FED8DD47AB82D1" modified="2018-12-05" version="1">MTIALSEEPVISLRGMEAANERFRLGPLDCDIPSGMVTVIVGPNGSGKSTLFRTLLGLEPILGGEAELLGERLDAALGDDFKTRIGLLTENPHPYEDGMTAEEKGRFASLWYPGWSWERYRKLLRKFDVDGRMKLSKMSKGMRRKAELSAVLAHDPELLLLDEPSSGLDPFAWKIMLEELRRYMEPGNRTLVVATHITEEVKRLADYILFLYRGKTLGMYEKDRLFDEWRTVIVQGAEASLIARTPGLQGMEEAGSGVYRIEVNEAEAAESWLNGCGFQVLGVQRMELEDILSCLIRKEEQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTI2</accession>
    <name>A0A398CTI2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_05710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04579">
        <property type="protein sequence ID" value="RIE04579"/>
        <property type="gene ID" value="D3H35_05710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="130"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="247" mass="27480" checksum="215C089DC612668D" modified="2018-12-05" version="1">MGRSVPVGFRVFCRRKGRCGKEGNAAFASCFPPFLAPERLDPAPRNGSNSQLDSAALRSNRQPVQRLPAPASIPGAIERDCAGVRSRRRAEVGSIRHRACHRSYESQLPKQARHGNGRRHRESDVKLIFRLFKKTTGESPIEYLTKLRMDSAKSLLSQKKCTIKTVSSAVGYEDEFHFSRMFHRHVGVPPTFYRKVKKLRVAVAASLPYRDSLLSFGVEPVASVNFSAIPEWPSKSTSSSSPANGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU25</accession>
    <name>A0A398CU25_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aegerolysin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02464">
        <property type="protein sequence ID" value="RIE02464"/>
        <property type="gene ID" value="D3H35_17345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019836">
        <property type="term" value="P:hemolysis by symbiont of host erythrocytes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009413">
        <property type="entry name" value="Aegerolysin-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06355">
        <property type="entry name" value="Aegerolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007951">
        <property type="entry name" value="PIRSF007951"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="163" mass="18497" checksum="E9FFFC782EF1D649" modified="2018-12-05" version="1">MQPNTTNCSGGEPMSDSLWVEVFIDNYNTDVVIRNIKLEWGRLYKLEDRSTEISADSLNGTVIKAGKKLWVCACGRSWSPSGTEGSFQLFDLEDKLIGTYSWDCPLGKRLNKTTWTKNDDTNFRFDFHPGNGNYGGYEKRDGTHIGRVTLRIWDASKPPYTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVD8</accession>
    <name>A0A398CVD8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03877">
        <property type="protein sequence ID" value="RIE03877"/>
        <property type="gene ID" value="D3H35_07865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="243" mass="27197" checksum="E58CBFDB4C6704FF" modified="2018-12-05" version="1">MERKSTGKTEKILLIIGFILGGIILILFIAAIIAAMLKRPRKSAMAIKELPVNPDTAAELAVPPPPTNEQRLARAIDLHNEGVAGNAEAVKEADREFERLRRDCPGNPVADAFHGSVKAMLARDETDLEERFLKAIDGLSLLDEAVAASPQDVTIRILRGKVAYWLPEPVFQRTETTIEDYVVVIDKELRKPGSLDGEIYFELIDELSQAYRRLNRQREAELCGRKLLVQRANRRMKQTGTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW27</accession>
    <name>A0A398CW27_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LTA synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_12140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the LTA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03411">
        <property type="protein sequence ID" value="RIE03411"/>
        <property type="gene ID" value="D3H35_12140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012160">
        <property type="entry name" value="LtaS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005091">
        <property type="entry name" value="Mmb_sulf_HI1246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="9">
        <location>
            <begin position="237"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="624" mass="70998" checksum="DAFE125653E4EA8C" modified="2018-12-05" version="1">MALLIKLGNRRFMLFTLLLLLKCCLAWFVVFEDGPSWTTMLTEIPFFWLVFCLIEWFAVKRKLLYYTIANLLFTLLYFTVLMYFKYYGIIVTYHALSQADKVTKVGNSTYSLMDPYYLLVFIDIVVLIAIPLWLRRSKSKKIQMNLKPIRKTVLSALFLMSIALCYFSIWPNRASMNENKQAEEMGILNYEIFTIFSDSTEDAELVDMEDITQPVIDNLKGNTEKPGTAYFGIDKGKNVIIIQMESFQNFLIGLTVDGQEVTPNLNKLAKENVHFDNFYTMVGQGTTSDAEFVVNTSLYVPKHEPATQNNVEKQLPSLPKLLGAQGYTSATFHTNEVEFWNRKELYDAVGFDRYYDKSFFGDEDHVAFGASDEVLYAKTAEELKKMRAAGKPFYAQIISMSSHHPYNIPENKYRMTLPERMEDTLVGRYIRAQNYSDYALGKFIDELKQSGIWDNSIVLLYGDHQGLPVYSLDNKEKDLMKDMLGHEYSYADMFNIPLIMHAPGVTSPALIEKTGGQIDILPTVANLTGVSIANQIHFGVDLLNQGQASSVLPMRHFLPSGSFVTDSDVFVPGIGFEDGTNYPLGLAQNTNADATQKQYENALELLHLSDSYVKQLPDKYPSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWU5</accession>
    <name>A0A398CWU5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 5">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rfbA</name>
        <name evidence="7" type="ORF">D3H35_06760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 5"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04307">
        <property type="protein sequence ID" value="RIE04307"/>
        <property type="gene ID" value="D3H35_06760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="292" mass="32156" checksum="3B1657D0307CAABB" modified="2018-12-05" version="1">MKGIILAGGSGTRLYPLTLITSKQLLPVYDKPMIYYPLSTLMLAGIRDILIISTPADLASFKRLLGDGSAFGLKLSYAVQASPDGLAQAFIIGEEFIAGNSCALILGDNIFYGNGLSTYLKKAVHNKNRATVFGYYVEDPERFGVVEFGKDGEAISIEEKPLHPKSNYAVTGLYFYDNRVCEFAKQVKPSARGELEITDLNKMYLEKGHLDVVTLGRGFAWLDTGTMDSLIDAASFVQTIEKRQGIKISAPEEIAFNNKWITLDELLAAARKYGKSSYGIHLNRVANGQIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX10</accession>
    <name>A0A398CX10_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PLP-dependent aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_03050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05118">
        <property type="protein sequence ID" value="RIE05118"/>
        <property type="gene ID" value="D3H35_03050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE05118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="485" mass="54124" checksum="AA339DDE9DC8C846" modified="2018-12-05" version="1">MLIPPPFDGSSNEPSYMRIYRFYREQILLGAIPRHAKLPSIRALAQHLGLSRNPVETAYAHLVAEGYVVNKEKSGYFAVELERPPSAEAPPASPADLLAGSTKTSADDEPIEPIKLDFSHDSVNMDLFPLRLWKQLSAQALREADRSLFHYGDGKGEPYLRNLIRSLLRQNRGVVCEPEQVIVTSGTQQSILILSSLIRSERGKLAVEAAMHPGIYRIFRQQHLRPVPIPLEEDGLSCDTLLTQASLSGVYVTPSHQLPYGTILPAAKRAKLLQWANRTNGWIIEDDYDSEFIYEGRPLPALQGMDKTGRVIYLGTFSKALAPAVRLSYLVLPPVLLERFDAEFAHYDQTASRLTQKTMELFIAKGHLDRHIRKMRKSYDLNRKTLIAAIETHFQGQANVSGASSGLHLLLRVHSNEPMEELVRRAAACGIKVDPASRYHVSEEESSTVFEQPGSPFSSFVMGFGGLTSEQIELGIRTLASVWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX50</accession>
    <name>A0A398CX50_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_11085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03574">
        <property type="protein sequence ID" value="RIE03574"/>
        <property type="gene ID" value="D3H35_11085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="225" mass="24825" checksum="C426E6D15C2F4635" modified="2018-12-05" version="1">MTIKAVVFDFDGTLMDTEKYAYEAFCGIYEEYGHKLALEKWALLIGTHNGPFDPYEELSGLTGLALDREELKKKFETGHLALLREAALLPGVKEALEEARARGLKIGLASSSDRSWIETHLNNQGIRHYFETIRSSDDVEKVKPDPALYRMAAADLGVLPEEAVAVEDSRNGMLGALNAGLHAIVVPNAVTRHMDFSEASLVVRTLENQSLAQLIEQVEGRISAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXD6</accession>
    <name>A0A398CXD6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CDP-alcohol phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_01630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05248">
        <property type="protein sequence ID" value="RIE05248"/>
        <property type="gene ID" value="D3H35_01630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="206" mass="22106" checksum="7AF478E1DEA0C896" modified="2018-12-05" version="1">MIEKWFPPLRYFGLANAITTAVSVCGLLSMVMFAQERFVGAFTLYGAAILGDYADGIVARKLKQTSEFGKELDSLADAISFCVLPAFCGYALGVTSPLGIAALVLFLAAGLWRLAYFNVSGLEEDGRHSYYTGVPTTIAASWLLVVSPLLLSVDFPGKTPLLAFFLAACGLLMLSSIPIRKNGLLTKSLYILLPAAVVLNWLLVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYI2</accession>
    <name>A0A398CYI2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLP-dependent aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_08880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04054">
        <property type="protein sequence ID" value="RIE04054"/>
        <property type="gene ID" value="D3H35_08880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="49"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="386" mass="41508" checksum="77587E4475819360" modified="2018-12-05" version="1">MVGKTAGTGGSEMTTIINWMGGWPKEGLVAASEWEERLAAAASEQKSGAASPVRKESESDSELRAAIAGDLLPGSGINEGAGLLVLVSGADAAIGKLAERLLSPGDVVLTEKLTSRSVLQLLRKAGVRIVPVGGDREGMNPEALQEALSIHRPRLVYAAPSCTDPEGAAWNKERLASAIRLCRKAGVLMLRDDRQELIRYGKKDLNLRSGVREEAGVLSVGQLPPGLVGGLKFGWVAGTSEDMERWLPPQVQAELQPTSLERAALAALLREQPLSPLLDMLNVQCGRKMRRLTELLALSQVPKLTWVSPEGGIHLWLTLPPALDGEALLRGAWLKGLMFQPGTPFYATEPQRNTVRLTFAFADDRQMKAGAARLIEAMGEFLGRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYJ7</accession>
    <name>A0A398CYJ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_06725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04301">
        <property type="protein sequence ID" value="RIE04301"/>
        <property type="gene ID" value="D3H35_06725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014985">
        <property type="entry name" value="WbqC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08889">
        <property type="entry name" value="WbqC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="239" mass="28128" checksum="74CFD548DD4A5C40" modified="2018-12-05" version="1">MKVAIHQPNYFPWIGYLDKMVKCDQFILLDDVQLSDNDYMHRNRFLDINGNVKYMTIPFQKKDYMKQKYKDIKINNTLDWQKKNAAFLGGNYKNAPYFNEINQLLMPLFNKHYNLLIDAILDSIELLRSVFEINTPMVLQSQLEYNQNSRKSDLVIALCKSCDADTYYSGRGAIEYMDSDQFEENGISIEYQQVNKFEYSQINSKEFIFGVSILDMLFNCGLEKSKQLFWDSIKEGAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ23</accession>
    <name>A0A398CZ23_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_02910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05097">
        <property type="protein sequence ID" value="RIE05097"/>
        <property type="gene ID" value="D3H35_02910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="89" mass="9718" checksum="1CBF9D720D37276A" modified="2018-12-05" version="1">MSAPGMRKSLDQPFERATKFYKDGILSGRSQLAVDQGNHDVSIDGNSGVNTPSTLKSGREGFTSVVFTIGFCSHSAIRRRTVLTVKRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0I9</accession>
    <name>A0A398D0I9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04674">
        <property type="protein sequence ID" value="RIE04674"/>
        <property type="gene ID" value="D3H35_04080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="182" mass="20450" checksum="0280D56EE8913BC1" modified="2018-12-05" version="1">MDGESYVRLAYDAIFKGDFEQAVCWFQQAMECEPSNAAYAYKASITCARSGKLALALEYAGRAVRLIPEDPQYSLHLRMLEAKDLTARAQAALAAMPAAPERAVPDLLQAVRLDPLSVEARVLLGIGHRMMGKHRDAVIAFRDALQLEPLHNEAARLLREAKAEWRNQLKRRFSNPTTNRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0Q4</accession>
    <name>A0A398D0Q4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CBM20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_04480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04744">
        <property type="protein sequence ID" value="RIE04744"/>
        <property type="gene ID" value="D3H35_04480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031965">
        <property type="entry name" value="CBM26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM_fam20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16738">
        <property type="entry name" value="CBM26"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017454930" description="CBM20 domain-containing protein" evidence="6">
        <location>
            <begin position="35"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="7">
        <location>
            <begin position="1105"/>
            <end position="1206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1206" mass="128572" checksum="AC141FEBB3A9F009" modified="2018-12-05" version="1">MKKKTRSLWSIVLFLALVLQALNFTPAVQGSASAAASEEYGLPANTKDGLIFHAWNWSFDTIKANMPAIAAAGYKSVQTSPIQGNKENLMEGSKWWVLYQPTNFKIGNAQLGNRDQFKAMCDVAEQYGISVIVDVVANHTGNAGGGSLEYTPATNVDPVIRNNPSFWHEARGVSDWGKRWEVTHWGIGLPDLNTSNQDLQNIIIGFLNDAIALGADGFRFDAAKHIELPNEDGGSNFWPRVLGSLSKQNLYIYGEVLQGGADNFAGYAGYMNLTASAYGHDLIKAVGFGANKNVDLARSYSSAGVSSSKLVTWVESHDTYANDKSETTYMTDWQIKMGWALIASRAETTSLFLARPGGSGKFGTGLGQAGKETWKDADVAAVNKFHNAMVGQGEYLRTISSDLMLIERGTKGMTIVNLGGDASINSVTNLASGTYVNQATGGGTFTVANGRITGNIGGGKIAVLYQEVKPTPKVSIDAQEGGFYTDSLTVKMTYSDTVSASYSLNNGTQTALNSGDTVTFGAGAAFGTTYSLKIVANNAAGQTTKTYTFTKEDPNAALKVHFYKPSGWGTPGMYYYDDSVTPTKIGAAWPGTAMTDEGNGWYSTQVAGWKQAKVIFTSGSNQIPGASQPGYTVTGEKWIKDGVIHTSNPDVVIKTPTVSIDKAEGAFYTDSLDVTISYNDATAATYSLNGGAPVSFTSGQKATFGAGAAYGTTYTLNVTASNADKTTTKSYSFTKTKTALPAPTISIDKAEGTFYGNSLEVTVSYANADGATYTLNGGAQTNVASGQKITIGADGAFGTKYTLIVTASNEDKSTTKTFTFTKEDPNAGLSIHFYKPSGWGTPNIYYYNDSVTPTKIGVAWPGVAMTDEGNGWYVFRVTGWTQGKVIFNSGSNQIPGASQPGYAVTGEKWIKNGVIYQSNPDTVIPENKTPTITIDKSEGSFNSDSLNVAITLKDATSATYSLNGGAPVSFTSGQQVAIGAGDAFGTTYTLSVTAINIDKTATKTYTFKKEEEQAITVRYYKPDGWGTPNIYYYDESVTPTKIGVAWPGVAMQNEGNGWYSYKLTGWSKANVIFNSGGQQTPASGQAGYLVTKSVWIKNGVITDQEPVQKTVAVTFTIKNATTVSGQSIYLVGNVAELGNWAPASAIATTASTYPTWKVTVNLVEGTKIEFKAIKKNASNGVVWESGQNRSYTVSSSNPTVEFNFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBE5</accession>
    <name>A0A398CBE5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000055">
        <property type="protein sequence ID" value="RIE00476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00476">
        <property type="protein sequence ID" value="RIE00476"/>
        <property type="gene ID" value="D3H35_28245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="270" mass="30024" checksum="CA69C10B19ED3D55" modified="2018-12-05" version="1">MERRGISARVLRGKGVGADRIVGILAERSLEMIVGILGILKAGGAYMPIDPDYPHERKGYMLADSSAHILLTQQKHKQKCDFTGEILFLEDFTLCAGDDSNLVSINNSGDLAYMIYTSGSTGQPKGVMIEHHGMLSLKCVFAETLFVKESDKITQFANSTFDASIWEIFMSLFTGAQLHILDKETIMNYKYFECYLNKHEITFATLPPTYLANLNPDNITTLTNLIVAGSASPVELFNKWNQKVNFVNAYGPTESTICTTIWKNVIPCKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCD8</accession>
    <name>A0A398CCD8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00846">
        <property type="protein sequence ID" value="RIE00846"/>
        <property type="gene ID" value="D3H35_26975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="52"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="110" mass="12297" checksum="8D73B28FB301CFE3" modified="2018-12-05" version="1">MDRRRPSLVVQCICSMPGARVYIGTDWGSCIQRTNIYIELLHAGGSDRCCREMYISGDGVSRGYLNQPELTVEKFVANPFAPGERMYRTGDLARWLPTGTSNTWDGSTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCE8</accession>
    <name>A0A398CCE8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_26140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000047">
        <property type="protein sequence ID" value="RIE00856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00856">
        <property type="protein sequence ID" value="RIE00856"/>
        <property type="gene ID" value="D3H35_26140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="58" mass="6346" checksum="5A144146FB49CD04" modified="2018-12-05" version="1">MSSIRLSSSPCGRCGTILIIYLAALQGVPHEMREAMMIDGAGKWKTFIHLTLPMIARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCU2</accession>
    <name>A0A398CCU2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SpoIID/LytB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00530">
        <property type="protein sequence ID" value="RIE00530"/>
        <property type="gene ID" value="D3H35_27690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013486">
        <property type="entry name" value="SpoIID/LytB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013693">
        <property type="entry name" value="SpoIID/LytB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30032:SF4">
        <property type="entry name" value="PTHR30032:SF4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08486">
        <property type="entry name" value="SpoIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02669">
        <property type="entry name" value="SpoIID_LytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPOR" evidence="1">
        <location>
            <begin position="140"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="714" mass="73158" checksum="44A7AEFC6A4E3776" modified="2018-12-05" version="1">MEARPLMTNDGNRFFKRILLLASAALIASSGSTGIVSYGAGTFSVPSQIRVGLFLNLGAGKFQSLTNAATLQSAGGLKLLWREPGGSYNIGNAAPGQSIRFALDGYKALVLETGDLSGAIAALKKMQASSSAAFITKVTKRGAPVYQVTEGVYSTAAAASTALEKWKNAGVAASVTALAPPKIAGPWAVEAGPYGSMAEASAAADRLGAAGLDAFVTLKLQSGGIAFGVRIGQESSAAALPALQQAAAAAGAPNVVIPEPSAKYAVVRNDMTVNGAAGSPMQLYAVPLAAGVTLRADPAADAPIQLVERSKRNYRGSMEASALNGSLAIINEVGLEPYLYSVVGAEVGSGWPAEAQKAQAVAARSYAVSSGMGFQIANVVDTTLSQAYNGTSSENANSTSGVNATAGEVVISGGKVFNAMFSSNAGGITADSKTEVWGNDVPGLASAVISPDSGAGAGQLNWYNVLLASGQTGYIREDLLVDDGQKNAAGLKLLRVKGEATTVRTKPIIDNTIAPVDKLSAGTIVVSLDKVPANGDYSWIEGPYTSEQMAALAKFVNATGPVKTVEITGVGPSGRITEVTVNGVPYKPSSPYGFRAAFGGLKSTLISVEQTGKYTVLDGNGTKRELPQAVGAVHVIDGDGNVSPSDGNLVIMDDKAQVRVVTGEPTFVIHGKGNGHGLGMSQWGARGLAEQGYDYKSILLYYYKNVTIEKDAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCW6</accession>
    <name>A0A398CCW6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA threonylcarbamoyladenosine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00553">
        <property type="protein sequence ID" value="RIE00553"/>
        <property type="gene ID" value="D3H35_27835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="PTHR43267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="11"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="249" mass="27375" checksum="0F95D10F707B2D74" modified="2018-12-05" version="1">MLHPFSRTELAIGPEGIEKLKGSTVAVLGIGGVGSIAAEALARSGVGRLILIDKDVVDITNINRQIHALTTTVGQPKADLMRDRIKLINPECDAISLRMFYTEETYEELFKYPLDYVLDASDTISYKIHLIKECLRRGIPLISSMGAANKMDPTRFQVADISKTSVDPIARVIRQKLRKEGIKKGVKVVFSTEDPMKPREDVTQRIVPDTAPKDIRKAQQPPSSNAFVPPVAGLIMVSVAVKELVERGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD34</accession>
    <name>A0A398CD34_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_22010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01096">
        <property type="protein sequence ID" value="RIE01096"/>
        <property type="gene ID" value="D3H35_22010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="18"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="253" mass="28123" checksum="BD2739AB9DF294E4" modified="2018-12-05" version="1">MNHSPFAGFDHEGPIRFSVLIPAHNEENYIGKCLDSIAAAAAPYPNQTEVIVILNRCTDRTEEIARAYGCVTLVDDSKNLSMIRNAGARIARGEFIVTIDADSMMTERMLTEIDSHLASGSYIGGGAAAKFERMSAGIVVSAILLIVPLLFKYGAVSIGIFWCRKSDFDAIGGFNEKMLMAEDADFAHRLKKWGKRQGKKYGTIKKAQMITSCRKFDKHGDWALVKQPSIIFAYLRGTDKDYADKTYYENQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD74</accession>
    <name>A0A398CD74_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_28495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00365">
        <property type="protein sequence ID" value="RIE00365"/>
        <property type="gene ID" value="D3H35_28495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="81"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="288" mass="31819" checksum="05E6C79C7936A5C2" modified="2018-12-05" version="1">MRCPENSKGGRWANEKDAKSVVRAGVILLALIVSIPLYLVIINAFKPHPEIVKHPLAFPTFEVGFDNMINAFEKMDLIKSYGTTFSIGALAMFIAVGLGALAAYAVSRIKHPFFSTMYWVYTACILIPIQSALIPVVLLMRDLHLQNSILGMSLMYGAMLSPFCIFMYSGFMRAIPYELEESAYLDGCSPARTFFQIILPLILPVTASLIIVQFISVWNDLQLPLVLLNSADHPTVSISLYKFFAGRSMSDLSLLFGGIMLTLLPIIVLFVSFQRFFVKGLSAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDI2</accession>
    <name>A0A398CDI2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_28260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000055">
        <property type="protein sequence ID" value="RIE00485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00485">
        <property type="protein sequence ID" value="RIE00485"/>
        <property type="gene ID" value="D3H35_28260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="3">
        <location>
            <begin position="1"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="420"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="573" mass="64736" checksum="6E2A601436674B7A" modified="2018-12-05" version="1">MEGKVDRERFERAFRQLIARHEALRTSFEWVEGEPAQRIHLEVDFEISYKKAEEDGLRQIAEFIRAFDLGQAPLLRVGLLELEPERHVLLYDMHHIISDGVSMDILVREFVGLYEGQTLPAPRLQYKDYAVWQQAFMQSEAMKRQETYWLETFSGELPVLEMPTDYPRPAVQSFKGDQIQFELDGELSAGLNRIAAETGTTLYMVLLAGYSVLLSKYTGQEDIVVGTPIAGRPHADVENIIGMFVNTLAMRSRPAGEKTFTAYLQEVKEVALQAYEHQEYPFEELVEKLNVRRDLSRNPIFDTMFSLQNMSEEETEIEEMRFSPYGFEHSASKFDMSLTAVETGREIGLSLSYCTAIYTKETAERLGRHYVALLRDISSQTEKQLKAIELLSAEEKRQLLHAFNDTKATYPANQTIHGLFEEQVKKTPDHTAVVLESESLTYAELNGRANQLARVLRGKGVGADRIVGILAERSLEMIVGILGILKAGGAYLPIDPDYPAERIGYMLEDSGADILLTQKRLQGQTMGFAGEVLHVDDERLYALDDTDLAHMGSSKDLAYVIYTSGSTGSRRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDT2</accession>
    <name>A0A398CDT2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01346">
        <property type="protein sequence ID" value="RIE01346"/>
        <property type="gene ID" value="D3H35_23525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="464" mass="49115" checksum="E748459049DCDDA9" modified="2018-12-05" version="1">MLSFRGMRDRNVFRNERGSILLYCMGILLVLVIVTPVILNGLSTQRLSTARMESDIQVNTLASGAAEAFLQHVGTNGNISKITTYQGWGEKTITLPNGNKVVLKQSAKNASGPVSASSININTLTNTGDPLIVTIEATSGKSSSKVYRYNLSATSSVPTVNSSQPKKITDSLSPGIKYVLTANEQNTTPPAPVAFKWDDEKLYTAINNKRDALVTEIKANITKYEAIGNNLKCGDCLGNPTIKKEPGTLTVSGSISRGGPSDPVILIVGSINVAASGGTLTVYGDVIADSIATINNGPGKLYIKGNLYSKNGINLNNPGDELIVDGRIYAKDTFQIEGPSDTTKVTKVTAESIVATNLYIRGNSKVTLTINDSIIVNAFEGISTDQMNITVTKSDLLAATSIKLNNSYNISAGGVIAGGYWIDRNRTTGSITASGAATALQCSDGSSIFTKCSSGNLAFQYKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE60</accession>
    <name>A0A398CE60_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00920">
        <property type="protein sequence ID" value="RIE00920"/>
        <property type="gene ID" value="D3H35_25455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="1">
        <location>
            <begin position="42"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="318" mass="34181" checksum="D6467E94DB05EC26" modified="2018-12-05" version="1">MKMRKTAVWQVVAILMITMLVIAGCGKNNEAGSGGSKSFTIGFANINDVYPYCVKVRDYIKEIAGAEGIKVVVANAAGDVKQQNDQIDNFIVQKVNMIAAISGDLDGSVPAVENSLNAKIPYVSLLTHVNTDGYVYVGSENKQAGEVQGEYLAKVLPENAKVLYMTGQTNDQQYIDRKAGLTAKLFDVRKDVQLLAEQSSDNQKDKGMSLTEDWLQSYGKFDAIIAQNDDSALGAVEALKAANRLDGVIVIGIDGSDDALASIEAGEMTMTVFQDAKSQAQAIVDLAKKLRDGAEASSLENINIPFKAITKENLSEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CED4</accession>
    <name>A0A398CED4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_26835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00805">
        <property type="protein sequence ID" value="RIE00805"/>
        <property type="gene ID" value="D3H35_26835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="259" mass="28910" checksum="0D7E8F8D2E94CAB9" modified="2018-12-05" version="1">MKVSETAQGVHLRIEGLNKTFGNQRVLQGVDLDIPAGQFVAVVGRSGCGKSTLLRLIAGLDAPSEGSIRSDDTEVTGIRDNTRMLFQDARLLPWKRVEANVKIGVKAGSDRERVLNVLRQVGLEEKAGEWPGVLSGGQRQRIALARALVSEPGLLLLDEPLGALDALTRIDMQDLIERLWDERKFTTILVTHDVSEAVALADRVILIERGQIKLDIAITLDRPRERDADFAYFEKLILDRILERDEHELRSKKELSYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEP4</accession>
    <name>A0A398CEP4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_25430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00915">
        <property type="protein sequence ID" value="RIE00915"/>
        <property type="gene ID" value="D3H35_25430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="187"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="292" mass="34426" checksum="BEE5B34C8E157785" modified="2018-12-05" version="1">MLLWEGFHMETNFYEAQNFDISREKKYQSSMPTQHYHNGFEIFYLVAGDVCYFINDKAYQVVGGVMLLIDVDEIHKLVNFSGDTFERITLVFKREFIEGIFPGNHSFDVLSCFLKDRHMLTFSGYEQSFIEKLFDKMISEFTKQPPGYEFYLKTLLFELLIFIYRHLESSQTKAYSEENNIVNRKIFDIVDFLNRNYDKQHTIRDISSRFFISPSYFCKSFRDSTGFTFTEYLNNVRIKEARVLLTQTGMKVADVAEKVGFENLTHFGRVFKEITGLSPLKYRQANRVNPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF37</accession>
    <name>A0A398CF37_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_28070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000053">
        <property type="protein sequence ID" value="RIE00502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00502">
        <property type="protein sequence ID" value="RIE00502"/>
        <property type="gene ID" value="D3H35_28070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="110" mass="12711" checksum="2809E439D341C8D9" modified="2018-12-05" version="1">MLASPEDFFHAHKNGVEDFEWLLSASDGSRLANDRQLIQVLLDLGAAYEKTDKPKRRRRLEASRALDPNTSIWRNRFTYGHYRERLEWKESTGKTEKYCSLSALFSAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF74</accession>
    <name>A0A398CF74_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_13735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01846">
        <property type="protein sequence ID" value="RIE01846"/>
        <property type="gene ID" value="D3H35_13735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="316" mass="35059" checksum="E0AEBA7770C311A2" modified="2018-12-05" version="1">MDIRQLRYFLAIANEGQITRAAKLLNMEQPPLSRQLKQMEQELGVLLFDRSGKRLKLTQAGELLRQNAERLLAQLSETIQQVKEFDEAVHGVLSIGAAVSCTSLLPPRISAFRERYPNVTFKIREGDHFLLYEQLENRAIELAVTRLPFESAPDSEAFAVMPLPSDPFVALIPSAWLPESFPESMSLRELADFPLLTLKTDRTTGMHEKVIHEFRLDGIDPYILCECSSVAIIVSLVAAGIGATVLPGSVISSFAIPGIKTASISNAGFHTDVGIVWLKDRYLSKSARTFMDMFTVSECDTMKDIESDGSVAPNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF84</accession>
    <name>A0A398CF84_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01240">
        <property type="protein sequence ID" value="RIE01240"/>
        <property type="gene ID" value="D3H35_22875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="251" mass="27064" checksum="8152B0E81334042E" modified="2018-12-05" version="1">MTTQDGSPFQLVMTIGETEGLRITGGDDAEPTINTPAWTRITDEVANAYRNGSISVGSNITSSITMAEQSKSSPFLSGRAAMTFMPSYYRSDIIAATEQKLFGDDWGIVTQPVDSRNPDRASQFSLPIVFAITANSPNSEAAWALLQDFLGPEKAEQDAKLGIYRTFARLPDEMDQGPQGNSVFYKLNPDGQSVIANIGRALNEKTFRFEQALVQAGNEELQAVVKGDLSAADALKRLQAEAEAGQFGSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFM0</accession>
    <name>A0A398CFM0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01225">
        <property type="protein sequence ID" value="RIE01225"/>
        <property type="gene ID" value="D3H35_22795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="266" mass="29561" checksum="E630A7D4952085D2" modified="2018-12-05" version="1">MKKNVLIVFAHPEPASLTRQLVDVAVHTLQEQGHGVMLSDLYGMNWKAVFDERDFPARDNPDRLSFITESGHAYSTGQQTADVVSEQQKLLAADAVILQFPLWWFSMPAIIKGWVERVYAYGFAYGYKGEGNRYRYGDGGLKGKRAMLSVTVGGPEKDYSPRGINGPLEQLLFPVTHGMLFYPGMDVLPIHAVYGTGRMTAADIDAAKSVWLLRLEHLFEEAPIPFRRQNGGDYPDRHVLASDIAVGQTGLMAHIAERHDDPVTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFQ8</accession>
    <name>A0A398CFQ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic lactone autoinducer peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01265">
        <property type="protein sequence ID" value="RIE01265"/>
        <property type="gene ID" value="D3H35_23030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009229">
        <property type="entry name" value="AgrD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04223">
        <property type="entry name" value="quorum_AgrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017275185" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="44" mass="5124" checksum="2DA9115A501785E3" modified="2018-12-05" version="1">MKKRSLHFVASALLFLASMFVLTACTWFFHQPEVPDELLKRKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG30</accession>
    <name>A0A398CG30_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000043">
        <property type="protein sequence ID" value="RIE00892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00892">
        <property type="protein sequence ID" value="RIE00892"/>
        <property type="gene ID" value="D3H35_25905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="425" mass="46628" checksum="BC80CE56821173C1" modified="2018-12-05" version="1">MEGSLVSGELSLLGVTDFYYNTISSQATLKDQGGNIVQEQQKIGRFWNSLTIPLDSPLQAGTYTLEFSVNYPGLAEPFQVNREVIVHSMDNNEIKGLVVEAEDESGEPLQNGHVMLFEKQLPNWSWFYSGYASNRTYDAGSIGDGKFFIPNAFLLAGKQYEVVVYGKSSDGMTDVFYNQPVSSGQANVKFTASSLKKLTFEASQAQAGQEVRVSLQNSDGLLVAWPFPVSFGADRKASMYIHTDNNLLVNSNLYDEAADTAYYLEKAYSLSSSATQTVNLAGPLVSITPPSGYDSAKLSINEGMPASKYYATQGISATVLYSLEKNGTSYTLSKLFSNLAKNERLSFDKNFSPRNSAQSFQNSANASVVNSDYYDNKDNYLYEVSSGPGSQFNGLNQTARFQVQTNEGSKKMLAVVRSRRCLPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG52</accession>
    <name>A0A398CG52_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_25470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00922">
        <property type="protein sequence ID" value="RIE00922"/>
        <property type="gene ID" value="D3H35_25470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017346906" evidence="5">
        <location>
            <begin position="23"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lacI-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="345" mass="37484" checksum="12F75B6E2B27165E" modified="2018-12-05" version="1">MKGRISLRVTIKDVARACGISAATVSLVLNDRECRVSEATRAKILKTAAEMNYRPNHLAVGLVTKKTKTIGLIVPDVGNFHFAEMSKAIEQECRNNGYIVILGSYGKSDEQAFAYFKEFIDKGVEGIIFAKPMLVELSETDRQCFSLAESANVPVVTFEPVAVSAKVGVVSYDYEAGGYLATKHLIDLGHRRIGCLTGPGNMISSIARTEGYKKALAEADLPFDPSLLYEGDFAVQSGAEALPHLLGQGVTALFTFNDMMALGVYKAARQYKLKIPTDLSIVGFDDTFLNEILEVPLTSVTHPADCLGEESAKRMLSLINGDSSYEGNLFPPTLMVRASSVRLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGD5</accession>
    <name>A0A398CGD5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_13420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01793">
        <property type="protein sequence ID" value="RIE01793"/>
        <property type="gene ID" value="D3H35_13420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="286" mass="32006" checksum="96BB7A90CE5C99AA" modified="2018-12-05" version="1">MGSDQLYSIGQAAKIGNISIQTLRFYDKIGLVVPSKIDKSSGYRYYSNADLLYLKVVQDMKAMNLSLKDIGHALKSDNLDGLLAKLEAKREETSDEIRRLERIGKSIEQRMSRIQFLQTLGNGLKDLDILVELKHFPDRPVLSDRRRTVCGMESSAAIFTEIIFKAEASGWGSARSMLTIFHDNIMTFDRGDTDLEFCILAEGAAEALPFSRTIPGGSYITALYCGLPNAESCKRIYGKLLDWIESSEYVESGPSIEQYLVDPTRLTNPEDFIVELQVPVEKGLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGI6</accession>
    <name>A0A398CGI6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01853">
        <property type="protein sequence ID" value="RIE01853"/>
        <property type="gene ID" value="D3H35_13770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="7"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="303" mass="32478" checksum="0E66841BAE4B4662" modified="2018-12-05" version="1">MTDKLLDCAIIGGGPAGLNAALVLGRARRDVALFDEGKPRNAVTRHSHGFITRDGITPGEFRAIAHADIAQYDSVQVHRVRVTAIRAEGSTFRVETASGEVVQTRKVLLATGLKDVLPAVDGIRDYYGKSLFSCPYCDGWELRDRALVVISETDSAAFHMAKTVYRWSQDLVLCTNGASVLTAEEKERLTAKGIVVDERKIVSLVGEDGFLEKIVFEDGEQLERNGGFVAGTWEHASTFGHSLGCEANEAGGLRTDDVGRTTVQGVYAAGDASVIAPAQLVIAAADGSRTAIAINSDLTHEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGN7</accession>
    <name>A0A398CGN7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00239">
        <property type="protein sequence ID" value="RIE00239"/>
        <property type="gene ID" value="D3H35_29840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="391" mass="42186" checksum="0D493444C8E50D01" modified="2018-12-05" version="1">MNFITLVGFEIRRTLRKPMFLVFQIIFPLLLIFILGSALSNSFQMKDVALKPVQVAWVQEDSGSLAASVDGFLQAPEVKSIVRITRVADREEAVKQVKAGETEFAVIVPAGFSDDVTQGKEANWEWIPGNDRSQNLVAESVFQSFLDHTNGMQAAAIALGPDAATTAAPGAQTAEGGEASYVHVGKLNAKYEYSSKQYYGASMLIMFLLYAGMGASFSLALEKEGHTLSRLNSTPVSEVTLLLGKVFGNFILTLLQSAVIVGFTTAVLGVDWGSSYLPIAIVCVSLSVLSISLAVIGTALIKNTKSLQMVFQIPIMVMTFLSGGFTPLPEEGAFGHLREFTVNHWAFQSLLNNMLGSDSSIVWHQTGVLAAIAATILALSVLAYRKVGYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGV5</accession>
    <name>A0A398CGV5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02436">
        <property type="protein sequence ID" value="RIE02436"/>
        <property type="gene ID" value="D3H35_17175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="151" mass="16167" checksum="BBC166497506CBF2" modified="2018-12-05" version="1">MAQNDFLIDLYVANSASSAPGTIDLHASAGDLITVSGTENLIQALRLRILTPLGELERLGHPDYGSRLFMLIGRLPGPEVNALATAYMREAIRREPRVASILRLEVGSLPGSPESLLIETELLANGLFAPVQLSTTIKLSTGHIEVKPNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGW9</accession>
    <name>A0A398CGW9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-type ATPase subunit b</fullName>
            <shortName evidence="11">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">atpF</name>
        <name evidence="14" type="ORF">D3H35_14590</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="10 11">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the ATPase B chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01993">
        <property type="protein sequence ID" value="RIE01993"/>
        <property type="gene ID" value="D3H35_14590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="45"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE01993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="161" mass="18364" checksum="B7625BB209B41226" modified="2018-12-05" version="1">MNFVWENFVIQLVAFAILFLLLQRFALKPLFGIMEKRRQTVLEQMESAQKNRAEADQYIEEQKQALQQARKEAHDIIEQAKTTGSRQADDIILSARNEATRLKEEAVREIESEKNKAIADLKAQVSGLSVLIASKIIEKQVDESTQSQIVDKYLQEVGSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH12</accession>
    <name>A0A398CH12_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_22955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01252">
        <property type="protein sequence ID" value="RIE01252"/>
        <property type="gene ID" value="D3H35_22955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="4"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="407" mass="43189" checksum="1AA88E8999564A4B" modified="2018-12-05" version="1">MSRLIFLGCVAYLVVGLGQLVVGTVMEPMVHAYGVQYGDGGQLVMNQFLGGLVGIVAAPWLMRQIGKKALLLSALGLLTVVQFVYLSEPPWMVMLTIGPIAGFGFGTTEAVVGSFIIGAAGANANIAMSRVEVFFGVGALLMPFAGAALIKAGYWKSAFGLVGSLAVVSIILWTMFWPKVLDATLNGTEHSEEEKARTAPSRESNRKTLLLVLIPCSVFFAVYVGFEMSFVHYLPSVLVQDSGMTESAAALILSVYWGAMTLGRMVAGHAADRWGGAAYLIWMCVACAVFSLVMGVWQGATSTFVFTFLAGIAMSGMFAIALVFANRAAPGMTEKTTSMLMAFGGLGGALLPKLTGWYLDEFGASATRWLFAILSVVMLGIIVWAVLAAKRARSGTGASDYRQISVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH24</accession>
    <name>A0A398CH24_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_29675</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00208">
        <property type="protein sequence ID" value="RIE00208"/>
        <property type="gene ID" value="D3H35_29675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="7">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="8">
        <location>
            <begin position="221"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE00208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="336" mass="37508" checksum="02661590D627DF0A" modified="2018-12-05" version="1">MTILIPSYEPDERLLGLIHQLKAVSDSTILVVDDGSGDAYSEIFDSAREAGCTVLTHRHNLGKGRALKTGFAYLQQKGATEGVVCADSDGQHLPKDIMRIAHAVNEHHDHVVLGSRHFTGKVPMRSRFGNSATRMVYSYATGTPIQDTQTGLRGYSVDMLDWLCRIPGERFEYEMNMLLEAKAAGYSLIEVPIDTVYLDENKSSHFRPLADSARVYFPFIKFCASSGFSAILDFVLLLLIQWVSANLFISVAGARLCSSIFNYTMNRSFVFAKGKEVAIGKSLPRYFALVIVIALLNYGLMHLLHERLGIPLIGSKLLTEASLFLFSYWSQRKFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH44</accession>
    <name>A0A398CH44_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_13400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01790">
        <property type="protein sequence ID" value="RIE01790"/>
        <property type="gene ID" value="D3H35_13400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="205" mass="23568" checksum="E185FC252F0960F1" modified="2018-12-05" version="1">MFLSINRIQKGGDRTQTAPYSALNRILSVTKALVLQHGCKKTTLKEIISSSGVSNGGVYHYVKSKDEIYGLILQKRLEQIDERFYREAEMNLEGPVSIIVNELFGDTDDCRVFRSVYLYLVSQPENERIRPIIRDFYDYWLKLGSDWVRLGQKDGVIHPDLDPHQISSYILSYYVGLLVNSAYVTDDAIFRQEPIIGFVKKLLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHG5</accession>
    <name>A0A398CHG5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SGNH/GDSL hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02656">
        <property type="protein sequence ID" value="RIE02656"/>
        <property type="gene ID" value="D3H35_18430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="326" mass="37275" checksum="9B017E94E02FD23E" modified="2018-12-05" version="1">MKFLLKALTAGMLSLMLWEVISRVAFYSSPATHDDPILGRILSKGIRISGEEGYSITKFNSLGMRNVELHQKNGNMRYLVLGDSYTEGLQVSDKQLFSSLLDNKSKTIDVINAGRSGASPATYIQLASYYKKEIDPDFTIIQLNQDDFYGDAFNKNSDFYVEKYQGQYRALKNEHLSRSNIIAEKIPQLNFISEISVVRKAFINLQNLIQSSPPKDKIQTFDHEAASWMLEQMKQSYTNVVVLYIPTIDYYHYENDNSLEDYLETKSSEIGLDFINMRLPFIESFQKTQQPAHGFNNTVPGTGHINKIGHKLIADELNKYFKQVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHV9</accession>
    <name>A0A398CHV9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_28870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00468">
        <property type="protein sequence ID" value="RIE00468"/>
        <property type="gene ID" value="D3H35_28870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07778">
        <property type="entry name" value="FGGY_L-RBK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042029">
        <property type="entry name" value="L-RBK-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="17"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="277"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="538" mass="59201" checksum="0BEF7A327AB3201E" modified="2018-12-05" version="1">MDHIDLKKAITKGETSLGIELGSTRIKAVLIDHRFRVIASGSCEWENRLKDGYWTYNQEDIITGLQLAYRELKQEVERNYGITLRTAGAIGFSAMMHGYMAFDSTGKLLVPFRTWRNATTGAAARELTDLFQFNIPERWSIAHLYQAILNQEEHVPHIDFLTTLAGYIHWLLTGNKAIGIGDASGMFPIEEATYHYNSLMTEQFNERIAANHYPWRLEDILPKVYLSGEQVGELTEAGARILDPVGDLQSGIMLCPPEGDAGTGMVATNSVRKRTGNISVGTSAFAMIVLEKQLSKVYPEIDIVTTPNGSPVGMVHANNCSSDLNAWVGLFREFSEAMGYETNFGKLFSVLLNKALEADPDCGGLLSYGYLSGENITGMERGRPLFVRSPESNFNLANFMRTHLFAAFGALKLGMDILTDNEAVAIDSIMAHGGLFKTAGVGQKIVAAALNVPISVMSTASEGGAWGIALLASFMVNKDEDESLEHFLEDKVFQNVEGQEMAPDRADVCGFEVFIERYRRGLAIEQAAVDHLLENGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI20</accession>
    <name>A0A398CI20_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional aldolase/short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00799">
        <property type="protein sequence ID" value="RIE00799"/>
        <property type="gene ID" value="D3H35_26790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013454">
        <property type="entry name" value="Bifunc_RhaD/ADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02632">
        <property type="entry name" value="RhaD_aldol-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="20"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="689" mass="74908" checksum="C9160BA2537EED1D" modified="2018-12-05" version="1">MVQSLWESEKASQQLSGLEQLVYRSNLIGTDRRVCNWGGGNTSSKTTVTDFRGREVEVMYVKGSGSDLATMKAGNFTGLRMDDIRPLFEKDDMSDEDMVAYLANCMIDAKHPRASIETLLHAFLPFKHVDHTHPDSIISLCCADNGKAVAKEIFGDRFVWVPYIRPGFKLSKMIAEGVLANPKAELVLMEKHGLVTWGETSEAAYAQTVKIISEAEAYIEARVQPDKLFGGVKHAALPQEARRSVAAQVMPAIRGAVSDAKKMILSFDDQEDVLAFVGGQDASVLSQVGAACPDHLVHTKVVPLYIDWTPSTDDVEGLKAKLKEGIASYKEQYKAYFERNKNEGDVMFEAAPRVILIPGVGMINTGKSWSNSQVSGALYHRAIAVMRGSTALGQFVSLSENESYNVEYWPLELYKLSLAPAEAEFSRKIAFITGGAGGIGSETARRLVSEGAHVVLADLNLEGAQKVADEVNAKYGENRAIAVKMDVTNEDMVQAAYAETALAYGGVDIIVNNAGLATSSPFDETSLKEWNLNMSVLGTGYFLVAREAFKLMKQQAIGGNMVFIGSKNSVYAGKNASAYSAAKALEAHLARCIAAEGGEFGIRVNTVLPDAILQGSAIWNSNWRNERAAAYGIEPDQLEEYYRKRTTLLVNIFPRDIAEGIAFFASSKADKTTGCMLTVDGGVPAAFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI36</accession>
    <name>A0A398CI36_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methylthioribose kinase</fullName>
            <shortName evidence="3">MTR kinase</shortName>
            <ecNumber evidence="3">2.7.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mtnK</name>
        <name evidence="6" type="ORF">D3H35_20160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>5-(methylsulfanyl)-D-ribose + ATP = ADP + H(+) + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:22312"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:78440"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the methylthioribose kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.100" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02926">
        <property type="protein sequence ID" value="RIE02926"/>
        <property type="gene ID" value="D3H35_20160"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00872"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046522">
        <property type="term" value="F:S-methyl-5-thioribose kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01683">
        <property type="entry name" value="Salvage_MtnK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009212">
        <property type="entry name" value="Methylthioribose_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031134">
        <property type="entry name" value="MTRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01767">
        <property type="entry name" value="MTRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="APH" evidence="5">
        <location>
            <begin position="32"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="111"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="246"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="410" mass="46594" checksum="43B4F492316FBDD8" modified="2018-12-05" version="1">MGYYHILKQAEAVEYARGIEGVFPAGAQLTSREIGDGNLNHVFQISDPASGRGLIVKQALPYVKVVGESVPLTLDRVRIENEALRIQDELCPDLSPKVYAYEQELALLVLEDLSDHIVMRRGLMNRGRYPFFGGLIGSFLARTLFFTSDLAMDLQEKKQRVKAFINPELCNITEDLIFDAPYKKSRMNIFEPHIRDAVERIWADTELHLEVALLRDLFLTKAQALLHGDLHTDNIFIKPDSMKVIDPEFAYYGPMGFDIGTVIANLLLNYSGQEGWSTDAQERIDYRRYLLDTVSDLWTQFELQFRELWNGHAADRMAKTRGYQDLYVARLLQDTIGFAGAKMVCRVHGFIHVADIERIEDAAARERAQRIALQIGTALIKRNRSARSIEELLDIALKASEDESERPSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI43</accession>
    <name>A0A398CI43_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stage II sporulation protein E</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">spoIIE</name>
        <name evidence="4" type="ORF">D3H35_23610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01682">
        <property type="protein sequence ID" value="RIE01682"/>
        <property type="gene ID" value="D3H35_23610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014221">
        <property type="entry name" value="SpoII_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045768">
        <property type="entry name" value="SpoIIE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19732">
        <property type="entry name" value="SpoIIE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02865">
        <property type="entry name" value="spore_II_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="615"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="851" mass="93512" checksum="985C464E6E8EB0C4" modified="2018-12-05" version="1">MDKPSVVPFVPRIGNGQQSSQHSVKRNKRKWLPHRHSSGRKADQPLSYWTTLLEALRAQLPLAGTLLIGFLLGRAEMLEGIAPFAAAFFGVVLYVRREFAFWAALSLACGSFFSIDPMPTVICAELGIIYLLFRGLEKYERADLSHAPVVVFAATLIVRLFDTVLTADKTEWLQYLLTAVEAGLAFVLTLLFVHALPVLTRKRKSLPLRHEEWIGLTILLACLMTGMTGWTVLGIAVAAVLTRYVVLISALAGGPALGTTVGVVSGVIIGLSDSAAASEIGLLAFGGLMAGLLREGGKAAVVFGLMLGTSVLALYTGDGTIAMVSTWASVAGSLLLLVTPKGWIEAVARTVPGTNGHAQTQQEYAQKVRDLTAERVARFSEVFRQLSRSFRQMTQHGESVRQDRDFEHFVGAVHKQACAACHKRAACWDGQQYVQTYALMTEMMTTVEQNPNVTSAQLPKMWTKLCVKTPQVLDVLKREYELYRHDLHWRRQLQDSRYLVADQLSGVSQVMDDLVNEIRREAKQLEKQEWQIRDSLERLGLAIQGIEIISLEEGHIEIEMIHAFRTGYDECRKMIAPLLSEILGETVTVARERTGEPAVHLSSVTFASAKAFEVITGVAGAAKDGDLLSGDSFSMMELGTGKFAVALSDGMGNGARARMESSAALSMLEQLLQSGIDERLAVKSVNSVLLLRSPEEMFATVDLALIDLYSAHATMLKIGSTPSFIKRGREIIPIAANNLPIGILHDIEIDLLRVQLQPGDTLIMMTDGIMDSPGHAINKELWMKRVIQEIQTDDPQELAEELLAEAMRQNPGGGIGDDMTVIVTKITRYQPEWAAFRFPGMGKMERPRTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI65</accession>
    <name>A0A398CI65_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000047">
        <property type="protein sequence ID" value="RIE00859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00859">
        <property type="protein sequence ID" value="RIE00859"/>
        <property type="gene ID" value="D3H35_26155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="14"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="283" mass="30988" checksum="C2491C400EF2FD57" modified="2018-12-05" version="1">MTPWTEGAENNLVKASVIGCGGMGTIHAERYASMPDVELVGVCDVNERSASVLGKLTGAGFYTDVQQMFDSEKPDVVSITVPTFLHLPIVKLAADNGVHVICEKPLALSAVEAEEAIQYCEQRGVRLFVGHVVRFFPSYRQLTESATRFGGVRGGVYHAKRAALIRGRFSLVQGSEQKRGVILDLMIHDIDYILGAFGEVSEVYAFNHLSRSWTTLPHLPIPERHDRAARSVLGYPGRSIPLSSTRARTESYGGQLGRGSLRVLRSQSGIRRTASSRRLKACC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI88</accession>
    <name>A0A398CI88_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_27805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00548">
        <property type="protein sequence ID" value="RIE00548"/>
        <property type="gene ID" value="D3H35_27805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="165"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="287" mass="32388" checksum="3DCA0860722EE62F" modified="2018-12-05" version="1">MSAPERFYANLFVQLAALTLLALYVYMTIPDEPNNGYWLAASGLLFLYGLLRPTVETILVSLGFVLIYGGLATYSLWFAASPVDADWNDLIWLVSFPAVSLLGGMNKERFTSQEDSAFAFLDPLDAPGIQQDEALGIEERFGFLSGPAFLYKLEEEVIKALRDRQKFHLVLIEVERLQEFKRIFGGVQAAILLNQLAEWLQKYSLSAKAKVGESMLACIVPEEDRSVVDEMQQQLAGLFLDMRMNRPRREANVKLQLRFGVSECPEDGIEARSLMESAQSVLRWKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ99</accession>
    <name>A0A398CJ99_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_11965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03386">
        <property type="protein sequence ID" value="RIE03386"/>
        <property type="gene ID" value="D3H35_11965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="279" mass="31276" checksum="8F7E313655612D30" modified="2018-12-05" version="1">MNIGAILFLLFSLFLGSFQTPVSEPVHVIDTESMEGVFGFTNADGTSIIVHGLGVGQEAAMSKWNKAIGESGKVLSVKYATYQKGNIDKSSGRDTSYNFENMAGYIFNVKEGSSTPNETYFLINENDFDLKALLPIKKTEDALKNDSLIAKEISAKKQRPITNIWQIAQFSDSQKLFLVKFKRQGDDMLFSLVLQREDKLLFNDFPAKTKDEISVWRVDDGGEVTPDMFSLLFAAKTSDGLALSIEWWGSEGENTFVIADDGEQFHELPISYYRYTYPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJN6</accession>
    <name>A0A398CJN6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HlyD family efflux transporter periplasmic adaptor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_17725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02530">
        <property type="protein sequence ID" value="RIE02530"/>
        <property type="gene ID" value="D3H35_17725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017329993" evidence="1">
        <location>
            <begin position="26"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="2">
        <location>
            <begin position="82"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="269" mass="29384" checksum="A25BCBDD930C32D6" modified="2018-12-05" version="1">MDKLSRNVKSIAVLTAALMLGTALSGCSLLPNEEEALKPPLVKPAQENYRTVKAEKGTITKEIKGNGALESLSTDVAEFAGQGGRIDKIYVKPGDTVKKGDVLVQLILDGMDIQLKEQQLTLERAKYAFSHTDPADEEARRLAGLQREIEQLKYDRLKKLFDGKSIKANIDGEVVFAESLKEGDFVEAYQKLVVVADPSKLRLSLSLDTSSENYTNVAIGSEAEITIKSTKLKGKVVQTPSSAPVTQNKVLAAKYANTMYIEVPAIWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJQ5</accession>
    <name>A0A398CJQ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-grasp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_20200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02933">
        <property type="protein sequence ID" value="RIE02933"/>
        <property type="gene ID" value="D3H35_20200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="128"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="409" mass="46161" checksum="0CAA2C39B9C70152" modified="2018-12-05" version="1">MTIEHFSDDIRLTILLTGGRAPVTLELARSFHSAGHRVLVAESARYHLCRVSRAVERSFQVPPPNENTKSYLDAIESIVTSERVDVIIPTCEEIFFIAKGLDRLRRHCTVWAAPTEQLGELHDKWRFVLLAERLGLTTPQSKLIRTREEWQALAEAERLNDDLVLKPAYSRFASQVLFLAKEHSHAKRRQVLSNIISAAVPKTPWIAQRHVYGRHICTYSVAYEGDLIAHAAYPCQYRVGQGATVYFKPLEHKAAQKWVRKLVKAIRFTGQIAFDFIEEEDGGLYALECNPRATSGVHLFGEDGGLVQAFLRPQELRESGAVLTPKPSNGAMLAPAMFASGIGGIRSFRELRSWHQAFRSARDVVFSRKDMQPSVEQLRVLIDAWRTSRARGIKLVHATTIDIEWNGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJY8</accession>
    <name>A0A398CJY8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000034">
        <property type="protein sequence ID" value="RIE03626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03626">
        <property type="protein sequence ID" value="RIE03626"/>
        <property type="gene ID" value="D3H35_10650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="146" mass="16101" checksum="D72E3E2762197819" modified="2018-12-05" version="1">MTTNYPELSDLVNLMEGRPSTNGWDVVCSYSVHQLNAFLKSQYEAGKLAREVVLTTEREDPITEMKYTVRYDIQFASPVLSFIAGRSGFATLTMPINEGSFARIIMADVEKRTIPIPGGRYSVQAIVPLAARSRGTPAKSSSMTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK24</accession>
    <name>A0A398CK24_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02695">
        <property type="protein sequence ID" value="RIE02695"/>
        <property type="gene ID" value="D3H35_18745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BIG2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="1">
        <location>
            <begin position="74"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="1">
        <location>
            <begin position="161"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="1">
        <location>
            <begin position="255"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="481" mass="48837" checksum="BC305257DDD5A684" modified="2018-12-05" version="1">MAKESEKQLTVTANYTDGTTKDVTLLAAYESSDSAVASVSEEGLVKGLTAGQTAAITATFEGRKVSATVTVTAELPVLTLDSYDFTLAKGSTKQLAVTASYADGSTKEVTAFATYLSSDPAVASVSAAGLVKGLTAGQTTVVTATYEKQKVSSTVRVASPPETPVISLNAYDFIVVQGNTRQLVVTANYSDGRTEDVTSLSVFQSSAPESVSVSAAGLVTGLSSGQQATITVTYRGQSLSASVRVVSSPEAPVIVLNSYDFTLVAGSVKQLLVTASDGDGGTEDVTALTAFRSSDPAVATASAEGLVTAITAGQAVVTATYLGQSVSATVHVTNKTVTSPGSGGAGMPPLIWTFDPPDWMTGLSPSSSWNTAVGREEASGEAIYRLNGESAMRLAKTASANTKVWTIGVKQSGSSVLVVPFPAAKAAFDISGGSGTILFATEAGSFSLPLSVLVLKANGALEGNEGEIRIEISPSEGPGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKM4</accession>
    <name>A0A398CKM4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00231">
        <property type="protein sequence ID" value="RIE00231"/>
        <property type="gene ID" value="D3H35_29800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025916">
        <property type="entry name" value="YdjO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14169">
        <property type="entry name" value="YdjO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="70" mass="8073" checksum="D6F0CF44437ECAAD" modified="2018-12-05" version="1">MYYSRKRPLEDIPMELTSIWSCSNEACKGWMRDNFALAILPVCPQCQSVMVKSEKMLSVLVNTSPNQFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL01</accession>
    <name>A0A398CL01_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01578">
        <property type="protein sequence ID" value="RIE01578"/>
        <property type="gene ID" value="D3H35_24845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="146" mass="16544" checksum="0AB5862C1688BE25" modified="2018-12-05" version="1">MVLFRKAITTDIPQLIKFRKILLGHEDNSSMDETFGNYFDSSLSDKSLVVWVADDDGVVVSTVCFCLCRLAPRFENPSGLVAYMANVFTIPNYRRQGIVSRLISEAIDDLKTQGIRKILLHSSDMAKPMYESFGFVEGNNYMFINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL23</accession>
    <name>A0A398CL23_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_27935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00597">
        <property type="protein sequence ID" value="RIE00597"/>
        <property type="gene ID" value="D3H35_27935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="311" mass="32794" checksum="72474B0743C65DD5" modified="2018-12-05" version="1">MVNITLVFSTALIFTALGGIMSERAGIVNIGLEGLMVAGAFASAVTAYYSQDAGFGKASPWIGLIAGMLFGVLFALLHAVATITFRADQVVSGIVINFVAAGSTLYLTKLLFEGAGQSPMVKERFYKWNIPLLSDIPVLGKALFVGYPTTYLALILVGVIYYLLFKTPFGLRIRSVGEHPSAADTVGIKVLRLRYIAVLMSGALGGIGGATIALTTTSSFSHNTISGQGFIALAAVIFGKWNPLGALGAALFFGFAQALNNFIQLFGFSNSIPSEFIYMLPYVLTILVLVGAVGRAKAPGALGEPYLQGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL67</accession>
    <name>A0A398CL67_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenosylcobinamide kinase</fullName>
            <ecNumber evidence="8">2.7.1.156</ecNumber>
            <ecNumber evidence="9">2.7.7.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Adenosylcobinamide-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D3H35_09080</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15769"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15765"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.7.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CobU/CobP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.156" evidence="8"/>
    <dbReference type="EC" id="2.7.7.62" evidence="9"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04086">
        <property type="protein sequence ID" value="RIE04086"/>
        <property type="gene ID" value="D3H35_09080"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043752">
        <property type="term" value="F:adenosylcobinamide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008820">
        <property type="term" value="F:cobinamide phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003203">
        <property type="entry name" value="Cobinamide_kinase/P_G-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02283">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RIE04086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="197" mass="21940" checksum="FA8DA8A87111EB5A" modified="2018-12-05" version="1">MMVVVTGGLGNGKSAYADEWAMSLGREAIRLSCPALPYESIEAGRPLPAARPGFVWKQFAADSRLTDKLNEINLESNLFRSESRVVVVDSLSGWLRARIYEALNAGAVFGEHAARVEKEWRKLLEAVFSFQGFCIVVTEDTVTGLALDPWEGWYAGQLARANRALSEASHRMFRMTAGVASEIKGHRAKRERRHERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLG5</accession>
    <name>A0A398CLG5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_27075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00687">
        <property type="protein sequence ID" value="RIE00687"/>
        <property type="gene ID" value="D3H35_27075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="118" mass="13108" checksum="DAF5D189F7A8E744" modified="2018-12-05" version="1">MIVDDSGVMRKNIRTILERGNHDVVMEVSDGREVLQNYIYYNPDIVTMDISMPGMDGIEALQGLLKVFPGAKVIMISAMGQKAQVLEAIRYGAKSYLVKPIEAQKLLSTVTNVINLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLN8</accession>
    <name>A0A398CLN8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_17420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03170">
        <property type="protein sequence ID" value="RIE03170"/>
        <property type="gene ID" value="D3H35_17420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="301"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="588" mass="67861" checksum="6739A8FF6F91E25D" modified="2018-12-05" version="1">MNLLILVLFIPIVILFTYSNNVAFKVIGKELQASNIKQLSFLSSQIDSRINQTMDFVFTFSRDPNVQKFNGLNLWDDRYDRMQTRYVVQEKMMLQSGVMNIWPVEYTVYSEQNKEAISNTSNTVEYDEDYLKRNMTGKWTYGDGEAVSAGEPKAFHWFYTNSFGQQGTLKGSNLVVHASFGHDNIQNMLDTYKAGGQGDPLFYHRGDAPILNRSASEQLSNEVIRYLDGQTLRDTMQDVVRLDSKRYLVSVVRSPHLNWYLVDIVPLEQILGPISSSRNFFYLSMVLLFAVGISASVLLYRNVQRPIRKLVKGLQSVQRGDFTVRIDANMNNEFAFLFYRFNDMSRQIQGLIENVLNEKLRAREATLKQLQAQINPHFLYNCLGYIINMAQMKDEEAVVSMGYNLSAYYRYITRMERPTATLDDEIRLIVNYLDIQKLRNGRIHYRIDIPEEMLKQQVPRLMLQPLVENAVIHGIGKSYSSGEIRIIGEMSGGFCRVYIDDDGPGMNPEQQEALNRTMREPLQEDMGCGLWNTNQRIINQFGNNSSLYFTKSPIGGFRTEIVWEVPAGDERQQHPPRQGDFRYANDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLR5</accession>
    <name>A0A398CLR5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_19220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03200">
        <property type="protein sequence ID" value="RIE03200"/>
        <property type="gene ID" value="D3H35_19220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="353" mass="39008" checksum="E9658CF521A4D4B4" modified="2018-12-05" version="1">MSNVVVLGGGYGGFRVIDQLIELNLPKDANLFLVDRLPFQGMKTEYYALAAGTVSELDIRSAFPLHPQLQTVFGEITEIDFDTRAVHITGHDPLSFDILVIALGCTDNYHGIQGAFEHSCSVQTLSSTRRTYQQLNNTNPYGQITIVGGGLSGVEIAAELRESRPDLNIRILDRGNCVMSAFPEKLQGFVSSWFREHDVEMRSHISITSLEQGVIHNSDEEILSDVTVWTAGIQPIEIVQRMELPKDKQGRLIVNEWHELPDHPNVYVIGDCSSQPFSPSGQLAEAQGKQVAQVINARWHGKDVKLGRIKLRGVLGSLGKKAGFGLMGKTPLLGRVPRMLKTGVLWKSKNHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM41</accession>
    <name>A0A398CM41_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase IV</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_07470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04416">
        <property type="protein sequence ID" value="RIE04416"/>
        <property type="gene ID" value="D3H35_07470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="2">
        <location>
            <begin position="7"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="419" mass="46661" checksum="0A596E9C9BC43807" modified="2018-12-05" version="1">MSPERTIFLIDGQSFYASIEKASRPELGDKPVAVGDPERKSGLILAACPIAKSKGVTTAERVGQALAKCPDLVVIRPRMQTYIAVSLFMTEIYESVTDQVEPYSIDEQFLDVTGSMACCGSAKEMAYRLQHQVLLSTGVRSRIGIGPTKILAKMATDNFAKKLPDGIFELSSDKLESDLWELPVHQMFMVGSRMTRHFVRMGLHSIGDIARLELGDFKRRMRREMRKQSDIQAEYYWQTARGIDPSPVVASIRGNLKSISHGKTLRSSLYRKLEDIEVVLLELVVEVCRRSRRHGYMGGVVSVGAGETDGERSRWFSRQMTLPQPSSLTHEIAAAAHKIFVGHWQGLPLSSLHVSLTQLSDDGVLQLTLFDDRPSAYRLERASDGIKDRYGSDAIMRASSLLQAGVARERAEQIGGHYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMD7</accession>
    <name>A0A398CMD7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000026">
        <property type="protein sequence ID" value="RIE04516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04516">
        <property type="protein sequence ID" value="RIE04516"/>
        <property type="gene ID" value="D3H35_05790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="99" mass="10561" checksum="3426641784EDEA9C" modified="2018-12-05" version="1">MGENAAPAEPEFDSVTVNGKQFSHVTSQYGLMTGETASFIVSVPAEASSTVRTELIRMSGIAGALAVVLIGLIAVMIRRRIVLRSFDSSCFLAVLQKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMH5</accession>
    <name>A0A398CMH5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_12600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03482">
        <property type="protein sequence ID" value="RIE03482"/>
        <property type="gene ID" value="D3H35_12600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="16"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="426" mass="46283" checksum="AC1E561EEB3CCB8C" modified="2018-12-05" version="1">MNTAEIRKQRFYYGWVVVLLTFVTLLVSAGVRSLPSVLILPFQEEYGWSRSGISSVISVGIFLYGLVGPFSAAMLLRFGIRKVVLTALLVLAVSMSVTPLMTSLWQFELLWGVVSGLATGMMANVLGVTVSQTWFVKRRGLVVGLLTASAATGQLLFLPLFAKLTSEFGWRYAVYTAVAVIILAFVAVAVWMRNHPYDVGAAPYGSEEVVKPTVFSGNLFLAPLQTLRFAMKNSTFWLLAGTFFFCGFSTNGLIGTHLIAACGDHGMLEVAAAGLLAMMGLFDLIGTTISGWLSDRFDSRWLLFWYYGLRGLSLLFLPYALGATPFMLVLFSVFYGLDWIATVPPTVKLTGMTFGKEKAGMIFGWVVVAHQLGASTAAYGAGVMRDWLGSYSQMFVTAGFICFIAALMAIRIGANMAKNAKASLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMJ5</accession>
    <name>A0A398CMJ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04586">
        <property type="protein sequence ID" value="RIE04586"/>
        <property type="gene ID" value="D3H35_05585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="129" mass="14638" checksum="37A3D5B96A94DC0C" modified="2018-12-05" version="1">MSFHFAGIDHVQLAAPEGREEDARTFFSGILGWTELPKPDSLKARGGVWFRCGAHQVHIGVQMDFMPATKAHPAFIVRGIGELREHLQRCGVTVIVDEMRADEGLCRFFVNDPFGNRLEFMEREEYGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMU0</accession>
    <name>A0A398CMU0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03785">
        <property type="protein sequence ID" value="RIE03785"/>
        <property type="gene ID" value="D3H35_09535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="313" mass="34539" checksum="FA793D4B9ED43DE0" modified="2018-12-05" version="1">MVHTIQKQLYRAFGFAVESGFALPELPRLEGEAELADVVIEAADLTADWNRLVEPNRKSVVLENRILFQIPGTATFDIQDGKKIRVCPAEDADEDQVRLYILGTSMGALLLQRRILPLHGSAIAVDGKAYAIIGESGAGKSTLASAFLRQGYSLVSDDVIAVTFAEDGTPMVTPSYPQQKLWQQSLDGFGMSNEHYRPIFRRESKFAVPVVSSYHTEPLPLAGLFELVKSDGEEPSLAPVRSLERLAVLHAHTYRQFWIPRLGLTDWHFQKTAQLSGKAGIYRLQRPATGFTAPELAAIILNTIQKDGSTYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMX1</accession>
    <name>A0A398CMX1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03642">
        <property type="protein sequence ID" value="RIE03642"/>
        <property type="gene ID" value="D3H35_10095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="104" mass="11249" checksum="EF43E13EBA926496" modified="2018-12-05" version="1">MDTYELASLSVAQGSEALPISFSRAKLMVVSDYGTRLWFIDVEGVADEQLLQRFAVSEEIGVSVKATTIGGRRLEGHGFFHPNPIHRAAAIRGNGELEGYGNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN27</accession>
    <name>A0A398CN27_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_08645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04013">
        <property type="protein sequence ID" value="RIE04013"/>
        <property type="gene ID" value="D3H35_08645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="19"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="236" mass="25455" checksum="D47B02E875662EF9" modified="2018-12-05" version="1">MTLDPSFIWTAFVQILQAIPTTLNITAVSMVFGLLIGTAVALVRTYRVPVLHPIAAAYVTVIRGTPMLTHLLLIYFGLPLIVDSLAEQFGWSFRSVSIPMIGFAYLSFSITAGAYLSEVVRSGLLAVSRGQIEAAHSIGMTLTQALRRIVLPQAFAASLPNLSNATIGILHGSTLAFTVSVVDINAQAQIVASTNWKFFEAYLAAALIFWGLTVLIERATALIEKRINVYDRGGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN45</accession>
    <name>A0A398CN45_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acid sugar phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_04680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. NagD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04776">
        <property type="protein sequence ID" value="RIE04776"/>
        <property type="gene ID" value="D3H35_04680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="288" mass="30537" checksum="04F4B7CBC617BDBA" modified="2018-12-05" version="1">MIDGLRKLPEALLFDLDGTLYRGDERVPGADRLVRALEERGVRCWFVTNNSSRTPEEVALHLEAMGIPATPDQVVTSATAAADYVRRTYPEAGVYVIGERGLKMAMAEAVAFVANESGEAAGAEAPDRKVDIVVQGIDREFTYERMTTAVRHILNGAAYIQTNPDRLLPVSGGFLPGAGSLGAAIEAATGVKPIVIGKPSPIIMDYALRLAGAAAERAWVIGDNPHTDLAAARDSGCPSILVLTGLCSRDDWRSRCEAADVTPDAVCAGPDELAELLLPLLDGADQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNF4</accession>
    <name>A0A398CNF4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02779">
        <property type="protein sequence ID" value="RIE02779"/>
        <property type="gene ID" value="D3H35_19270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="93" mass="11115" checksum="C5AD7A1FD2D65AFD" modified="2018-12-05" version="1">MRHCSVQVRGLLTRDELDRYNALMEVGSYLESQARYDLSAVVQAEVDLLIVPGIERLKEKGRERDRMTEEFLEQQRRAEWERQMRETLDNDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNL6</accession>
    <name>A0A398CNL6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000053">
        <property type="protein sequence ID" value="RIE00504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00504">
        <property type="protein sequence ID" value="RIE00504"/>
        <property type="gene ID" value="D3H35_28080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="113" mass="12139" checksum="AF9481F6668A57A1" modified="2018-12-05" version="1">MKSGGNAEAVKEADASSSAAPRLPRQSGRDAFHGSVKAMLARTRPTWRAISEAIDGLSLLDEAVAASPQDVTIRILRAKSLIGFPSLYSNDETTIEDYVVSSTRSCASRKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNN4</accession>
    <name>A0A398CNN4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01527">
        <property type="protein sequence ID" value="RIE01527"/>
        <property type="gene ID" value="D3H35_24555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="111"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="625" mass="72100" checksum="A96E6612791FCFF8" modified="2018-12-05" version="1">MVEITFYENELTLISNNETELTRVHIIKQIQRLGFESKDVGKFVCLGSNHLALANLLSLLEVRGINYQMDHNASSLYQQYQEELELIELLRVQGLEAQNVEIIPPIEIKGLKRKLFPYQEKAFNHMVTVQNPANFSVPGSGKTTMAYAYFQYLKNNNIVDKMLVIGPLSSFRVWEEEYIECIQGASPSQIKRVHGQNRHSVYGDRRFSIFLTNYQLAYRDKDLIISHISETGRYLIVIDEAHYIKNPEEGAIKNALLSIAPYGVRRMIATGTPCPNSLLDLHSQLTFLWPSEAVTGSKFEFQKLIEDVEVVRARIKPFFYRIQKQVLELEEPHTNVISVTMSDIQKKIYDSIVDKALNFITQYSVNDAQLLRWRRAWAIRINQVMSNPSLLIDDSNEEFEQGYVPALDKHVVELVKDYSKLEIPAKFTATFIKLLELRSKGVNKVVVWTNFKKNVQMLKKLLIPEGWEVKVVTGDISNNENVLENRDQVIEEFRNTTRPAILLATPASCAEAISLHKHCHDMIFMDLTFNAAHWMQAKDRIHRIGMKKGVDTNYYVFQTENSYDQTIYERVIRKENKMIAVCNSDIPIPTENDDEISFEGFITNEDEVFSALEAELAAWESMKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNY1</accession>
    <name>A0A398CNY1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase</fullName>
            <ecNumber evidence="3">2.7.1.49</ecNumber>
            <ecNumber evidence="3">2.7.4.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">thiD</name>
        <name evidence="3" type="ORF">D3H35_17315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThiD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.49" evidence="3"/>
    <dbReference type="EC" id="2.7.4.7" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02458">
        <property type="protein sequence ID" value="RIE02458"/>
        <property type="gene ID" value="D3H35_17315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="2">
        <location>
            <begin position="19"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="277" mass="28753" checksum="78161A46A0936588" modified="2018-12-05" version="1">MDKESGRKVARALTIAGSDSGGGAGIQADLKTFQELGVYGMSAITAVTAQNTLGVQAVYPLSSEAVAQQIRAIGSDIGADAVKTGMLFSSEIILAVAGVIQELGWTKVVVDPVMIAKGGSVLLQEEAIRALTGTLLPLTAVVTPNIPEAEKLTGMDILGRTDKEEAARRLAGFGAQHVIIKGGHDSGTEAVDLLFDGRYFTELASKRIATGHTHGTGCTFSAALAAGLAQGLDIESSMQQAKAFIQAAIEDGIHIGGGRGPTNHWAYRRSRLPLSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPE6</accession>
    <name>A0A398CPE6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">rsgA</name>
        <name evidence="10" type="ORF">D3H35_07365</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04395">
        <property type="protein sequence ID" value="RIE04395"/>
        <property type="gene ID" value="D3H35_07365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04466">
        <property type="entry name" value="S1_YloQ_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031944">
        <property type="entry name" value="RsgA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16745">
        <property type="entry name" value="RsgA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="65"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="8">
        <location>
            <begin position="74"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="114"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="173"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="301" mass="33413" checksum="9404457574FF27C4" modified="2018-12-05" version="1">MPTGTIMKALSGYYYVKGDDSGETLQCRARGIFKKRGQSPLVGDRVIFEETENGEGTVDEILPRDSALIRPPVANVDLAVLVFSVVRPELNIQLLDKFLVHIEHERLDALLVFTKLDRIPDDEDGERIRRDVEAARELYESIGYDVLLTSAHQGEGIEELRQRLAGHIAVFAGQSGVGKSSLVNALVPGLTLETAEISDKLGRGKHTTRHVELVSVNGGGIVADTPGFSQLDFAELGIDEIGSCFREFRRLADGCKFRGCSHTHEPNCAVQDAFGRGEVSASRYENYKSFMTEWKEIKRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPK4</accession>
    <name>A0A398CPK4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_11560</name>
        <name evidence="2" type="ORF">D3H35_25920</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000044">
        <property type="protein sequence ID" value="RIE00874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00874">
        <property type="protein sequence ID" value="RIE00874"/>
        <property type="gene ID" value="D3H35_25920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03318">
        <property type="protein sequence ID" value="RIE03318"/>
        <property type="gene ID" value="D3H35_11560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="264" mass="28546" checksum="28058E6C566A1D4E" modified="2018-12-05" version="1">MGQRIVTGLVAGTAFFCLLWLGDWYYSLLLVAMAIIGYSEFAKLNGHAWSRWDVLAGFVGVIILALTRLPESWGVSLPSFATVSWLLMFALLAATVFSKNKIQLEHAAVLFIGAIYVGTGFHYMAATRELDHGIFWSMLTFVSIWTSDAGAYFVGKAIGRTKLWPAISPNKTIEGALGGLVLAVVAALAFAYFGSEWIGYGRAALIGLTAAIAGQLGDLIQSAYKRFRGVKDSGNLLPGHGGVLDRTDSWLIVFPLVHLLTLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPK9</accession>
    <name>A0A398CPK9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02658">
        <property type="protein sequence ID" value="RIE02658"/>
        <property type="gene ID" value="D3H35_18440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="125" mass="14647" checksum="8E119E15BB255AA2" modified="2018-12-05" version="1">MLKLGDKIIIVGDRFEQNLPLEEYGYLIAYDRNNDSAFDYIIRVPKANRQYYVPASDVELEETLFGQEAERIEREALIDFALATRNEELFRRIMNGEEAAEPEESGKEVLSREEFIRQVNLKAWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ07</accession>
    <name>A0A398CQ07_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zn_dep_PLPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02838">
        <property type="protein sequence ID" value="RIE02838"/>
        <property type="gene ID" value="D3H35_19605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029002">
        <property type="entry name" value="PLPC/GPLD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00882">
        <property type="entry name" value="Zn_dep_PLPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_dep_PLPC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="315" mass="35574" checksum="93FAFAB0CECF94F6" modified="2018-12-05" version="1">MPSIWAHIQFGRELLDDVGESGNMKKSDWKRAFQLGCQGPDFLFFHHFWPWQSTTLVNRLGTLMHNTDCGPFLLSLFDSARSRREEDPASAYVLGFLLHHILDRHLHPFVFSRSGFRKWRHNRYETIMDSAIMHLRSGIHTGSVPVAPEVDTNGLLPGEGFAEQFLRISALHYPAIASRIDVKQLNEAVADTIKAQRLFFDPAGWKGTVLAGQLAPFSPPRRIPDWDVLNVRRERWIDPCDRTVFHQESAMELWELALADGRATTGAALAYLRANASEAAETREAFAALLGNLSYETGRSCGTAWIRFADSVLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ48</accession>
    <name>A0A398CQ48_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">trpD</name>
        <name evidence="8" type="ORF">D3H35_03970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04655">
        <property type="protein sequence ID" value="RIE04655"/>
        <property type="gene ID" value="D3H35_03970"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="3 5 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="7">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="6">
        <location>
            <begin position="81"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="5">
        <location>
            <begin position="91"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="5">
        <location>
            <begin position="98"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="5">
        <location>
            <begin position="116"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="349" mass="36679" checksum="378475D7C10AFA82" modified="2018-12-05" version="1">MSEQAVGMTLPQGLAKLVGRADLTREESFGIMTTIMRGEATPAQIGGIMIALRMKGETVDEITGFAEAMRSFSSHVQTENADLLDTCGTGGSGIHKFNISTVSAVIAAAAGARVAKHGNRAMSGKAGSADVLEALGVNINLTPEQAGACLERTGICFMFAQLYHPALKHAAAPRRELGVRTIFNMLGPLANPANADRQLIGLYDRTMTETVANVLGRLGLKRAMVVGSHDGLDEISISAPTQVSEMRNGVVTTYNITPEELGLASVKLGEVTGGDAAENSQIIRRILGGERSAYRDVVLANAGACIYVSGRAESLQDGVRVAAQTIDDGLALNKLNEWIAMTGEVSHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQL1</accession>
    <name>A0A398CQL1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01711">
        <property type="protein sequence ID" value="RIE01711"/>
        <property type="gene ID" value="D3H35_12935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="126" mass="14660" checksum="1C5BFC397B94D98E" modified="2018-12-05" version="1">MPDGCKVETALEILVGKWKPIILFHLFGNGTMRFSELQKAMPDITKKMLTSQLRELEYHDIVHRKIYLQIPPKVEYSITEYGKRMTPLLQSMNDWGIAHVEHLNELYGEDRSVEPFTDKAEEIVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR87</accession>
    <name>A0A398CR87_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_02675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05053">
        <property type="protein sequence ID" value="RIE05053"/>
        <property type="gene ID" value="D3H35_02675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012505">
        <property type="entry name" value="YbbR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07949">
        <property type="entry name" value="YbbR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="455" mass="47989" checksum="E6709F0A567CE39B" modified="2018-12-05" version="1">MAAVDKWLSRPTVLKLVALAIGIIMFAVVHFDPASTPNNVASLYENRVIDGVKIQPYGLDERNYVLLGLDPQKVKLTVRGTKSDLYAASTDDYKIQADMRTVGEGTMTLNLQFDLPKGIQLVQITPSTVTVTVEALETKEFEVSITTIGEPEQGYKAGTPVIKPSNRVHVTLPKNTLAKVERVGASIPIKGETETIKSKSVKLAAYDSEGNIIEGAIIDPTVVEVEVPITNPFKQVPLQFKLQGAMPAGLSIATFKPDIELVTVYGPQEALDKIDFVEADVQLAELTQSGKVTVPLKLDPPITQISPNETVISIEVVLSATRSLEGLPIKLNGLGEGLIATITDPSTGKADISVKGAPSVLDRLQPGDVQVKAELTGKGPGTHTVDLTVYLPRFIEQAGGTKTITVEIAGDVPATAPGEPDVTTGGEAAGEDGEGTSSPSPSPSSSPQSSDSPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR96</accession>
    <name>A0A398CR96_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_02730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05063">
        <property type="protein sequence ID" value="RIE05063"/>
        <property type="gene ID" value="D3H35_02730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="198" mass="22711" checksum="BBC58CBB12E0124E" modified="2018-12-05" version="1">MEKNKFQLKREATYQQMLQAALLCFSEKGYTSTTLGDIVARTGHTKGAFYGHFKSKEELFFHVLDYQNQQTQGWTDVPKHYSPADTTLEEVIRLTVVSLAEKLQGVNNWIVVLLDFYLQTKHHPEYHERLKAKYGLWISEISTLVRVLQEQGWVSPDKDIRLTAMQVIALNEGYTIFSVLFGGVNDQALIQGLVRLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRP5</accession>
    <name>A0A398CRP5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PKS_DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05255">
        <property type="protein sequence ID" value="RIE05255"/>
        <property type="gene ID" value="D3H35_01665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_DH" evidence="1">
        <location>
            <begin position="80"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="200" mass="22712" checksum="B1254AFEB958A787" modified="2018-12-05" version="1">MEIVWKYRGQVTPRNDKIVVDLDILETGRDDHGVYAIAEASLWADGLQIYYVPRMGMRLVEDDGSGAKLSTLTNEAEPAIAESLFDPNQQPWIRDHCPTYTAPAMPSTFMLEFMAAAVQKQEPNLRIVGVADVQFKRWLICDRPRRLRTEVRRAAIRSMTTAPHGMRPFFLLGGMRQTPGCRGSRKWPPADSLWHSATRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRZ3</accession>
    <name>A0A398CRZ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_17940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02567">
        <property type="protein sequence ID" value="RIE02567"/>
        <property type="gene ID" value="D3H35_17940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="58"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="92"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="311" mass="35564" checksum="53D09B42D2FE96F2" modified="2018-12-05" version="1">MAVAIIINVISNLIEDYIRMLENLNYSVKAKQMKEQIAEKSIIKSAHGKIPFRFHEQIDISNLSFTYPNIQIESLKNINLTINKGELIAVLGENGSGKTTLVKLLLGLYKVECDSIFYDGIPINQFDENSLYNNTSAVFQDFIKYQTNVRDNIAVGDITYVNNDEKLESALNRVLFDNHFPGGLNTKLGYIDQDSTNLSGGQWQRLALSRVFVKDNPELIIFDEPTSAMDPLSEMRILNEVLRYCKNTTTIMISHRVGIARKADKICVLQQGQIVEFGTHDELIKSKRNYYEMWMSQKEWYEDVEDKIPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS55</accession>
    <name>A0A398CS55_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_13305</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01774">
        <property type="protein sequence ID" value="RIE01774"/>
        <property type="gene ID" value="D3H35_13305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039498">
        <property type="entry name" value="NTP_transf_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14907">
        <property type="entry name" value="NTP_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="655"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="414"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="745"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="778"/>
            <end position="785"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE01774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="982" mass="110787" checksum="138D6FEBFF8B9DD4" modified="2018-12-05" version="1">MRRAMRQKKYTAEERLLFNCLAAFIQRNKVTMTDGEPDWPSFLALANKHRLFPILYNVLKQEPSIPEFVLDILKKDVEFNQRVMLEMTATIAGLLKELEDRGIDALILKGIPLAIDLYGDVSLRTSRDVDLFVAPEHYEQVEALLIQKGFANHAGFSDINPSMKRYIIENKDSHYHTEFHHHSRPLTIEIHWRQQSATYGKTAFAKLWQRRAYCRLGSYAFPTLGAEDQLDYLLLHGAKHMYARLRWLLDIVLHLKKYPSLVQEKAKHPQLQDLLAQAKLICSELWGQALPPSIRVTDRSKSLAKQAIHFVVMDDEVKDILFGTPDYFRYKKYLWDVKWTWRDRLQYVGEHFQPTISDLALVPCRELGIRYIFWRVRLRLSKSDGSSLEVRMEAYISFIRSFCQFSGWKLASFVVLSVIFGFIEGIGILTLIPILSVAGMSAESTGGPFASLFSWLNEQALSGEQLLTIGLLLYLLLTVFQVLVQRQVALTNVQLVQGFAHRLRTSLFSRLLKAPWADVSRYGITVQHIISQELPRIAQGVNAILQLLIAMTVTVLQLGIAFCISVKFTLMIVVCAALLMFFGRNYFRSATDLGTSMSGLMRKSFAMMLDYVSGIKDMKAYQLEGKAGIEFASTSRLIFSRFSEHAALTTRTTTILKLGVSIFICAVVYISVALLKVPFSHLLVLLVIVARLWPRFSSANMQLQQAALLMSSFSQYKSVSERLREEYDAITSESDWKVKRLHRHIALNNVSFAYKDGRAALSGVSLQIPAKELTIIIGASGSGKSTLLDLMMGFQQPTEGTIMIDGEALNSSWLACWRQSVSYVGQQLHLFNGTVRDNLLAVKDRATEEEIGEALRLSGSESIVAKLPNGLDTLLGEGGEALSTGERQRLVLARALLKEPTLLLLDEVTSALDIKNEADIMRTFSALREKTTIVMVAHRPTVLPYADRIILLREGAVVKQWSKQEGISVEQILLEMAQAEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS77</accession>
    <name>A0A398CS77_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lrp/AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04089">
        <property type="protein sequence ID" value="RIE04089"/>
        <property type="gene ID" value="D3H35_09095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="68"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="163" mass="18415" checksum="56D80D0A8F6A8F9A" modified="2018-12-05" version="1">MNDFKLSILDLLKEDARLSAKTIATMLGAQESEVDAAIAEMEQEHVIVKYATVINWSKVDDQTVTALIEVECTPERGRGFESIAERIFLYPEVKSVYLMSGAFDLLVEIEGKNLKEVASFVSNKLSTIESVISTKTFFILKKYKQDGIIFEEFEDDHRLIVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSA2</accession>
    <name>A0A398CSA2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pullulanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_13605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01824">
        <property type="protein sequence ID" value="RIE01824"/>
        <property type="gene ID" value="D3H35_13605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045424">
        <property type="entry name" value="DUF6509"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20119">
        <property type="entry name" value="DUF6509"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="96" mass="11020" checksum="D22F133AE1F4B78A" modified="2018-12-05" version="1">MFTVTKHSVEAAKDPFGILVGKRYEFKLDLEVDEEDELYSENGIYARVVFKVDEDKTSIVTCNFIEKSTDRVLDFDPEADEEETLAAYCKENLPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSU4</accession>
    <name>A0A398CSU4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02034">
        <property type="protein sequence ID" value="RIE02034"/>
        <property type="gene ID" value="D3H35_14820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="101"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="191"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="281" mass="28521" checksum="28CC341BAD4A8D0E" modified="2018-12-05" version="1">MSATTVAAPLTDLASGAITGSTVELSWTAAVGASSVTVEVSTNGGSSWKPATVETAISANASTAKVTGLLAGTDYKLRLNVTGGENNGLSNVLAIKTANEVVTSLAVTGKSANTVALSWSSLIRASSVSVEFRTTGGEWQPASAGALSSSSKTATVRGLQANTEYEIRLKVVGGANEGASYPVSVKTDALKLTSLSNTGKTSSSVTLKWTVPARAASFGILISTNGGVSWGVVEYPELGLDSTSATITGLSAYTSYKFKLAISGGDYEGESNEITVRTTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSV3</accession>
    <name>A0A398CSV3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03838">
        <property type="protein sequence ID" value="RIE03838"/>
        <property type="gene ID" value="D3H35_09815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="211" mass="25337" checksum="F7EC3848D1A34F09" modified="2018-12-05" version="1">MDAEAQQWDGVTFFRRFEGANAQQWDGVTFFRRFVDANAQQWDEVTFFRRFEGAEAQQWDGVTFFRRFEGANAQQWDGVTFFRRFVDANAQQWDEVTFFRRFEGANAQQWDGVTFFRRFVDANAQQWDGVTFFRRFVDANAQLWDEVTFFRRFVGANAQLWDEVTFFRRFVDANAQQWDEVTFFRRFVGANAQQWDGVTFFRRFVGAEAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT46</accession>
    <name>A0A398CT46_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_15370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02134">
        <property type="protein sequence ID" value="RIE02134"/>
        <property type="gene ID" value="D3H35_15370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="67"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="259" mass="28911" checksum="0B011030A2F73429" modified="2018-12-05" version="1">MSGVISKAIQMLDLLVPQGIEKEMSMTEMSRELGWPVQSVHRILKSLAEHGFVTQNAKTKKYKLGLSLMKYGFLMHDSLMLRSVARPFMEQLVEKTGETVYLATRENAEGVYIDSIDSPQILKISEPIGLRLPLFIGASNRVILAYLPKKTREALLSAADWTSVPSLKSLTREYIESEMELIQAQGYAITTGEATSETTGIGAPIFSYENTVIGSLNCAGPSSRFTPENIEKYSCYTKKYADLISAELGFRNRARLNFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTD8</accession>
    <name>A0A398CTD8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureD</name>
        <name evidence="4" type="ORF">D3H35_21205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UreD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03097">
        <property type="protein sequence ID" value="RIE03097"/>
        <property type="gene ID" value="D3H35_21205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="PTHR33643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="297" mass="32611" checksum="11AC8FFA588AABCF" modified="2018-12-05" version="1">MCPLSDTAKAEAPDRLSELKAVAGTIDGRTQLVSRYHSSPLKIAKTFSVGTVADPQLAVMQMDGSPGLLEGDRYVFDWHLLDEAQVYATNQAYTRVHPCGQGNTRLTQRFRLEKNAVLEWIPEPIMLFGRAALAAETEVELAEGALCVWSDIFCPGRMSRGEAFEFRSFDAKLSVRHEGKLIHYQRQKWQPGVLPIDSPGCFGGFTHLGSFGVFSDRVGAELVQKIRGALEAAEAALPGSRIMWGAARTAKHGIVVQAAGHAAWPLQRLVLAAWDSVRSELLGRPPMRLLKEAWMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTE5</accession>
    <name>A0A398CTE5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phage tail sheath family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_18020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myoviridae tail sheath protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02581">
        <property type="protein sequence ID" value="RIE02581"/>
        <property type="gene ID" value="D3H35_18020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035089">
        <property type="entry name" value="Phage_sheath_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020287">
        <property type="entry name" value="Tail_sheath_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04984">
        <property type="entry name" value="Phage_sheath_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17482">
        <property type="entry name" value="Phage_sheath_1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_sheath_1" evidence="2">
        <location>
            <begin position="306"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Phage_sheath_1C" evidence="3">
        <location>
            <begin position="457"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="569" mass="61355" checksum="FAAF9CF8A9B71DED" modified="2018-12-05" version="1">MAEYLSPGVYVEEFESGSKPLEGVSTSTAGFIGLAQRGPVEGLPQLVTSPADFQRQFGGYLSESAFGSYRYLAYSVDQFFANGGSRCFVMRVAPSDAKAASNEGRGAEALSIVAKNPGAWGSLVKVVVTPASKAKTQIYEANGTRYRVKSTNGFYAGDVVTFTSGGDTQWNRIVSVQDGVIELAEELDGDVVDAALLPTKLLATSEFDLIVAFGDEVEQFDKVSLNPEAPSYVDKVAARSNLVQVQSLIVSEGAVAPFEAVTGVAEGKLEFVLGGGSDGTVGSIAASDFMGEDRGPGRRTGIQAFIDNDVVSIMAVPGVTDANVQLALVAHCENLGSRFAVLDIPREKTKVADVLTHRDLFDSSYAALYNPWLSVFDPLDKRNIFVPPSGTIAGIYSRSDTSRGVQKAPANEVLRGVVGLDVQYNKGEQDILNPKGVNLIRSFPGQGIRVWGARTVSSNPLWKYINVRRLFIFLEESIKTGTNWVVFEPNNEQLWARVQRTIDAFLTRVWRDGALMGTSAAEGFYIDIGRSTMTQDDIDNGRLICVIGVAPVKPAEFVIFRITQKTGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTH9</accession>
    <name>A0A398CTH9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03147">
        <property type="protein sequence ID" value="RIE03147"/>
        <property type="gene ID" value="D3H35_15640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="4"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="423" mass="46267" checksum="90F1FB856C0C9089" modified="2018-12-05" version="1">MRMEYDVIIVGARVAGSALAYELAGAGYEVLLLDRGTFPSDTLSTHNIYGNTVAMLKEMGVLDSLLATGTPVYRRAHMNFEGAVLDGRFPGTEEESGCLCVRRVYFDDVLFKHAKSQRGVTVLEGFRVTDLLRDGDVDTVTGVAGRYRSGDAGSFTAKLVVGADGRLSSIRKLAGSECLERVPTDFASYVAYASGFAQEGERHVEFYKKDDKWAIAFPTSDGQFVIGAMFPLNDEQWLGRFKENPEAGMRDLYEEGFSHTTLPARVRGAEFVGPVRGLLGYDNDFYRGMGKGWAVVGDALSFKDPTIGQGMHDALFGARTLAATLSEHKPDEWNDNWGPMGEWYQSAMEKKLMSRFRMGCQLTKNVPTPPETVAAYRLIGADEAATQTFFGTYNYKNEPDDIGPEIGRLLAAAASASGKVSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTJ9</accession>
    <name>A0A398CTJ9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing ligase RtcB</fullName>
            <ecNumber evidence="4">6.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rtcB</name>
        <name evidence="5" type="ORF">D3H35_17585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3 4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3 4">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RtcB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.-" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03177">
        <property type="protein sequence ID" value="RIE03177"/>
        <property type="gene ID" value="D3H35_17585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="PTHR11118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="1">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="199"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="323"/>
            <end position="324"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="368"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="393"/>
            <end position="396"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU371113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="474" mass="52372" checksum="2B100C685680E5D8" modified="2018-12-05" version="1">MSKNENYYRRVDLPAGELHVFAKDELFEAMGARTLEMANNNLQIPDIRYMSYTPDAHVGVGTCIGTTAVWETERAFVSPSIVGSDIGCGMRVHVTNLKAEDLKDVKLRRKLVKAIEKRLPVENHARGYFSDIRLEDALRKGLHGLPGKYVPDAYTPRKATSLTHVECSRFRFDESWLDRIPEQLWHRSHRQLGTLGGGNHFVEIQAVDIDEGNRRIAEQWGLQDGQVIVMIHSGSRSWGGAVNQYCGSEVAKTMRLLGLGTADPKLAFAPLDSEAGQAYANLMYSALNFAVVNRHLIGYAIRDAFKDTLGAPFEMRTLYDLMHNYAWEERHGDASYFVHRKGATRSLPAGHPDNPAPYASTGHPALIPGSMGTSSYLMVGSPEGARNYYSICHGAGRVRSRNATKQLVTVDEFASSLRIGQDDEIVVNHKGLESIIDESPQAYKDVDQIIESVVGAGLATVVAKCRPMATVKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTY0</accession>
    <name>A0A398CTY0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_11555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03317">
        <property type="protein sequence ID" value="RIE03317"/>
        <property type="gene ID" value="D3H35_11555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="52"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="225"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="271" mass="30479" checksum="6B7DDF75CCE673D8" modified="2018-12-05" version="1">MGNSGSRGWLRLLGFGASGKDGSDRKRKGTDAGTDVPSGGNIPQHVAIIMDGNGRWAKARGLPRIAGHHNGMKTVKRITKLADEIGVKVLTLYAFSTENWKRPKAEVEFLMKLPQEFLALELQELIDKNVQVRMMGQKDVLPSHTVAAVEEAVRRTEGNTGLILNFALNYGSRNEMVDAVREIARSSADGKLDPEAIDEALFERHLLSSGLPDPDLLIRTSGELRLSNFMLWQLAYSEFWFTDVYWPEFGQQHFYDAIREYQRRARRYGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU93</accession>
    <name>A0A398CU93_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HEAT repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02554">
        <property type="protein sequence ID" value="RIE02554"/>
        <property type="gene ID" value="D3H35_17860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="156" mass="18437" checksum="1FBE4265B4C3F1EB" modified="2018-12-05" version="1">MKRAITPDLFLKEFTVDISKNPAYVRELLEKAYIEQEADDVEYLMIAIFRFELFLEDITESICKLMNETWHFQHENIASMFQKVKSPRTIECLYNAALTQFEYLEYDEAFALAVKCIWALGDINTLESRKKLMQLTQSENEIIKENATKQLNRSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUB1</accession>
    <name>A0A398CUB1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarate hydratase class II</fullName>
            <shortName evidence="3">Fumarase C</shortName>
            <ecNumber evidence="3">4.2.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Aerobic fumarase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Iron-independent fumarase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">fumC</name>
        <name evidence="6" type="ORF">D3H35_05120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04849">
        <property type="protein sequence ID" value="RIE04849"/>
        <property type="gene ID" value="D3H35_05120"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045239">
        <property type="term" value="C:tricarboxylic acid cycle enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="PTHR11444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lyase_1" evidence="4">
        <location>
            <begin position="11"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="5">
        <location>
            <begin position="406"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding (B site)" evidence="3">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="137"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="322"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="3">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="462" mass="50332" checksum="B8FDD1F156B28C88" modified="2018-12-05" version="1">MDYRIEKDTIGEIRVPGEKLWGAQTQRSSENFRIGTEKMPIELIRAFAVLKRSAATVNRSLGKLEIEKAEAIEASADEVLEGKWDDHFPLVVWQTGSGTQSNMNVNEVIARLANQKLERQGRAERVHANDDVNRSQSSNDTFPTALHMAALTAVERQVLPAIVALKATLDDKARQFANIIKIGRTHLQDATPITLGQEISGWHRMLEKSETMIRLAAESLRELAIGGTAVGTGINAHPKFGELAAEEISRQTGLAFVSAKNKFHALTSHDEIVFVHGAFKALAADLMKIANDVRWLASGPRSGLGEITIPANEPGSSIMPGKVNPTQSEAMTMVVCQVMGNDAAIGFAASQGNFELNVFKPVIAYNFLQSARLLADVMHSFNDHCAVGIEPDAAVIRGHLERSLMLVTALNPHIGYENAASIAKTAHKEGITLKEAALRSGLLTEQQFDSIVRPEEMIQPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV38</accession>
    <name>A0A398CV38_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Cysteine synthase</fullName>
            <ecNumber evidence="5 11">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cysK</name>
        <name evidence="13" type="ORF">D3H35_07480</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5 11"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04418">
        <property type="protein sequence ID" value="RIE04418"/>
        <property type="gene ID" value="D3H35_07480"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005859">
        <property type="entry name" value="CysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01139">
        <property type="entry name" value="cysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 9 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="8"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="9">
        <location>
            <begin position="181"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE04418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="311" mass="33001" checksum="2B91D9C8BE96537D" modified="2018-12-05" version="1">MSRIAKNITDLIGNTPLLELANFTKNHSSHAALIAKLEFFNPAGSVKDRIGFAMLRDAEQRGIINRDSVIIEPTSGNTGVGLALAAAALGYKLIITLPESFSVERRKLLLALGAELVLTPAPEGMAGAIRKAEEIAVALPNSFVPQQFNNPANPDVHKETTAEEIWRDTDGEVDIFVGGVGSGGTISGVGERLKEKKPSVRIVAVEPFDSPVLSGGNKGVHKIQGIGAGFVPGNFNRAVVDEIVQVKNDDAFETSRQLARTEGLLVGISSGAAAYAALQIAKRPENKGKKIVVLLPDTGERYLSTALYPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVF7</accession>
    <name>A0A398CVF7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">7,8-diamino-pelargonic acid aminotransferase</fullName>
            <shortName evidence="4">DAPA AT</shortName>
            <shortName evidence="4">DAPA aminotransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">7,8-diaminononanoate synthase</fullName>
            <shortName evidence="4">DANS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diaminopelargonic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bioA</name>
        <name evidence="6" type="ORF">D3H35_20495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate</text>
            <dbReference type="Rhea" id="RHEA:16861"/>
            <dbReference type="ChEBI" id="CHEBI:16490"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="EC" id="2.6.1.62"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.62" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02984">
        <property type="protein sequence ID" value="RIE02984"/>
        <property type="gene ID" value="D3H35_20495"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00834">
        <property type="entry name" value="BioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005815">
        <property type="entry name" value="BioA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00508">
        <property type="entry name" value="bioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="117"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="319"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM" evidence="4">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="453" mass="49285" checksum="8666283774F2AF5F" modified="2018-12-05" version="1">MTTYGERLAAMNKAHVWHPFTQMKDYNNSEPLIIERGEGIRLFDMQGRAYYDGFSSVWLNVHGHNVPELNEAIADQLGRVAHSTLLGMANIPAIELAGKLAEIAPQGLTKVFYSDSGATGVEIALKMAFQYWHNRGTKGKTTFATMNQAYHGDTIGAVSVGAIPLYHETFRPMLFPSRVIPYPYAYRHEGGEQGAMESTLSALRQLLETEADRIAALIVEPIVQGASGIIVMPPGCLREMAALCRKHDVLLIADEVATGFGRTGAMFACELEGVAPDLMVVGKGLTGGYLPVAATLATDKVYEAFYADYEEQKTFFHGHSFTGNPLGCAVALASLKLLEERRMVEGVEAKASFVARKLAALNDRPHVGEIRQKGLMIGIELVRDKVSREAYGWTERIGVRASLRARELGMLTRPLGNVIVFIPPLASSEAELDEMTDILAASIVHATEGGTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVW8</accession>
    <name>A0A398CVW8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional ligase/repressor BirA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Biotin--[acetyl-CoA-carboxylase] ligase</fullName>
            <ecNumber evidence="1">6.3.4.15</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Biotin--protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Biotin-[acetyl-CoA carboxylase] synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">birA</name>
        <name evidence="3" type="ORF">D3H35_04110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:11756"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.15" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04678">
        <property type="protein sequence ID" value="RIE04678"/>
        <property type="gene ID" value="D3H35_04110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00978">
        <property type="entry name" value="Bifunct_BirA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030855">
        <property type="entry name" value="Bifunct_BirA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="2">
        <location>
            <begin position="68"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Biotin binding" evidence="1">
        <location>
            <begin position="119"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="331" mass="36049" checksum="8876D7976FD3F5F7" modified="2018-12-05" version="1">MSNVSLLELLEAEAGAYVSGEDISRRLNVSRTAVWKQVRKLEAQGYTIDAVPRLGYRLSGKPSRITALELLPKLNTRAFGRQLRIMDVVPSTQDELRKLAEEGAPEGTLVIAEQQTSGRGRMGRAWVSPAGKGVWMSLLLRPLVPLPLTPQLTLLAAVALSRAIARVVPSLSIGIKWPNDLLVDGKKISGILLESAAEDERLRYVVVGLGVSVNLEPDDYPEELLERAVSLKMANGGKAIDRAELIAVILEEFERLYDLFAERGFAPIRALWEAHSVTLNHTVRLTTPTGTLIGVPRSLDEMGGLRVELPDGSFQTVYSADIGDPGTRGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW64</accession>
    <name>A0A398CW64_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyrrolo-quinoline quinone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03451">
        <property type="protein sequence ID" value="RIE03451"/>
        <property type="gene ID" value="D3H35_12390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017331692" evidence="1">
        <location>
            <begin position="28"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="498" mass="54187" checksum="9EFB113F3AA16BC8" modified="2018-12-05" version="1">MKAFLGKRSLSLLLLSLMLLVQGTAEAQSIISYKWSQLPKPQQFPEVYTEVEGVLTFRGSSERSAPAFGTTEMKQFKPVIAWNKATKKSSWGGGAGWTGQPAIVKWSPEVLKTMNVKAKFLKKPGFTEVIYASLDGNVYFLDLQTGEETRSPIKIGNPIKGSVSVDARGYPLLYVGEGIPEKGTIGFSLFSLTNQKRLYYMSGKDPYAKRTWGAFDSSALFNREEDTLVVGGENGLFFNIKLNTAFNPAQKSIKVSPVVSKYRYQIAGNSYQGIENSVAVYRNLAFFADNGGSLQAMDLEKNVPLWTLPASDDTDASIVIEQEEGVPYLYTGTEVDKQGIGGYSFLRKINGLTGKVVWTRKYPCFSLLGEHPVNGGLLATPALGKKEIGHMVIFTLARHGTFKGGLMVAVDKKSGKELWKLPMKNYSWSSPVDVYSEAGKAYIVQADSVGNVSIVSAIDGKVRGTANVGANVESSPAVFGDYAVVASRGGKIFGLKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWG3</accession>
    <name>A0A398CWG3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_11835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03364">
        <property type="protein sequence ID" value="RIE03364"/>
        <property type="gene ID" value="D3H35_11835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="24"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="411" mass="44158" checksum="C670613BF9623B60" modified="2018-12-05" version="1">MGQRASSGNSAITQQRPATLQRRHFIIFAAATILYWSSMYIYVPILSPYLQDRNLSMAWIGFILGSYGLTQLLLRLPLGIYSDRMSRRKPFLIVGMVASLGSCLLFMLPGGWEAPLAGRLLAGICASTWVPFSVLFASYYPADQTQKAMGTLSFLMVSGQFVGMAASGLIADLGGWNAAFWTGVAISLIGTAAAIFIREPKQPSPSSKAVPNTVFADTSEVLRSPRLWMFAILSLLAHGILFITMFGFTPLQATQLGASEGQLTIIVAAFMIPHAFISLISGRSLALRFGTQRVIVVGFAAAALFTALIPSSTNLWWLSLTQALNGAAQAMYFPLLLSLAIRGFAPTQRATAMGLYQSVYSFGMFLGPYLAGGLNSYGGLKAGFWFGASLGIIAAIISSGKSLRNEQQATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWX6</accession>
    <name>A0A398CWX6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PhzF family phenazine biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03514">
        <property type="protein sequence ID" value="RIE03514"/>
        <property type="gene ID" value="D3H35_11975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="297" mass="32957" checksum="D6ADD5EADABD797E" modified="2018-12-05" version="1">MNETIVHHYDAFSMYPNQGNPAGVVLDADHLSEQDMQRIAFDIGFNETVFVVRSEQATVKLKYFTPGHEIPLCGHATMAAVYALKTRGKLGDAQRLTIETNVGVLPIELTETEGVHRSWTIKMKQDNPRFLPFQGDREKLANAIGLDVRELDSSLPIVYGSTGTWTLLVPIKSLQSFREMKPQNEKFPELLTELPKASVHPFCLETYSTDARMHARHFSSPFSGTIEDPVTGTASGVMGAYYLEYMNPELPSAAFVVEQGQEIGKEGRVGVEAIRSEHDGMCIYIAGTAVYVKDLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX36</accession>
    <name>A0A398CX36_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-layer homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05138">
        <property type="protein sequence ID" value="RIE05138"/>
        <property type="gene ID" value="D3H35_02965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="58" mass="6185" checksum="C409C134BCE2B651" modified="2018-12-05" version="1">MDIGFADDNVIPQWAKSSVEAARKEGIVSGRNGNQFVPNGTATRAEAIVILLNTLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX94</accession>
    <name>A0A398CX94_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PqqD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03831">
        <property type="protein sequence ID" value="RIE03831"/>
        <property type="gene ID" value="D3H35_09770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="97" mass="11106" checksum="12CA84016A0D81EB" modified="2018-12-05" version="1">MGGYIVSVVYRRLDQVEVVELDGETLVLNPETFAVTKLNEVGGWVWRTMDDCATFEQLEQRMTETFDADRRRMSADLTLFLNEMIGIGLIKIAKDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXN2</accession>
    <name>A0A398CXN2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_08515</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03991">
        <property type="protein sequence ID" value="RIE03991"/>
        <property type="gene ID" value="D3H35_08515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="53"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="360"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="393"/>
            <end position="400"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="601" mass="65934" checksum="C5F353490B88D342" modified="2018-12-05" version="1">MVQGAMREAECVLLGGGGRMVKLQYWQEFKRAMSYMKPRAWTYGIGIVGNNVIAALGLNILMAFIYKDIVNAAVGSDMPLLLRSIGTAFALLAVSSLLCTILTYRYNASIRYTMTDIRQQTFRHVQRLPMSRFENTHSGEMLSRMTNDLNTIEHLYADSLGGIIYAVVVGFAAAIAMFALNWPIALFAIALGILTFYVNTRFADSFRKINDEIQRGTGKMTQALSDVISGVPLVKMFSLGGVIIRKYDQTNEDVAGLSTKRTRKYAYLDSVNSVLGSLSFVGIVIVGGAMALKKGTDFGTVMAFIKLQGNIGFMFSQAGNLATDVQRVLAGANRVFELLDDPVEREGSERSLLGDEKKAIELDGAVFRYGEGAPALDRLSLAVERGQTVALVGPSGGGKSTVVKLLLGFYPIESGSVKYWGRSGQSYSLSEVRDMIAYVPQEAYLFDGTIEENIRYGNMDASREAIIAAAKAANAHEFIQEQPDGYLTAIGERGSRLSGGQKQRIAIARAFLKNAPILLLDEPTSALDAESEKQVQDALRMLAKGRTVILVAHRLSTVEHADRIYVIDRGQSVEEGRHEELIRKQGLYERLYRLQLKDAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYC0</accession>
    <name>A0A398CYC0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Disulfide bond formation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_06275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DsbB family. BdbC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04221">
        <property type="protein sequence ID" value="RIE04221"/>
        <property type="gene ID" value="D3H35_06275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00287">
        <property type="entry name" value="BdbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003752">
        <property type="entry name" value="DiS_bond_form_DsbB/BdbC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012187">
        <property type="entry name" value="Disulphide_bond_form_BdbC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023380">
        <property type="entry name" value="DsbB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43469">
        <property type="entry name" value="PTHR43469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02600">
        <property type="entry name" value="DsbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036659">
        <property type="entry name" value="BdbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158442">
        <property type="entry name" value="SSF158442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="153" mass="17018" checksum="2DBE60FC1536855F" modified="2018-12-05" version="1">MSLKTFIRTYGLLFAWIVSLIATGGSLFLSEVMDYAPCKLCWIQRIFMYPLVYLLGRAAIRDDRGMIGYALPLVFIGGLFSVYHYAEQKIPGMADLLPCTVGVPCNSDYLDWFGIITIPLLALIAFILIAFFLIMAKPSSTEESTDGEPARSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYL1</accession>
    <name>A0A398CYL1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_09070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04084">
        <property type="protein sequence ID" value="RIE04084"/>
        <property type="gene ID" value="D3H35_09070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="5">
        <location>
            <begin position="117"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="345" mass="39036" checksum="3C73001B32954330" modified="2018-12-05" version="1">MSERLREDWSRNERDSASSVGTESESGSYYAPIVHIVEAADAGRTVRDVIKNRMGISRRLMIKLRTAEEGLSVNGRRAWTKDRVTTGDRIELRMLEEQSETIFPQPMELDIVFEDDHLLVVNKPAGLIVHPTSGHYLNTLANGVVHHWNERGERIRFRPVHRLDEHTSGLVVIAKNQYANQQMASQMMQGGMEKRYRAYVYGKPPLTEGEVNEPIGRSSDDPHRRIVREDGAASLTFYRLANEYECGASAMDIRLGTGRTHQIRVHMLHIGCPLIGDGYYVDERLSYSPLSVKLADVIERQALHAVELAFDHPVSGERMRLTASLPEDLLRLEQELAANTRGEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZY6</accession>
    <name>A0A398CZY6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04771">
        <property type="protein sequence ID" value="RIE04771"/>
        <property type="gene ID" value="D3H35_04650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02240">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044266">
        <property type="entry name" value="PSP_YsaA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="263" mass="29246" checksum="75921F0BE8D1AB16" modified="2018-12-05" version="1">MSLKAVLFDLDDTLLWDDRSVKEAFEDTCRVAAEETGVDPSALEDAVRQEARALYETYETFPFTQMIGINPFEGLWGHFTKGEHPMFRKMQEIVPGYRRQAWTRGLAALGVDDAGLGERLAESFPAKRRELSHVYEETFRVLDELKGKYKLLLLTNGSPDLQQEKLDGVPSLIPYFDAIVISGSFGEGKPSPRLFAHAMEKIGITAEEGIMVGDKLTTDIKGANGVGMTSVWINHHGAEPTGDIKPSHIISRLAELPDLIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0S9</accession>
    <name>A0A398D0S9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04774">
        <property type="protein sequence ID" value="RIE04774"/>
        <property type="gene ID" value="D3H35_04665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="322" mass="36835" checksum="646D04B617E6DBE4" modified="2018-12-05" version="1">MDTGSHLLFGATIAGLSHLQPEIAADQTLATVVLIAALAGSHAPDLDAVFKLRSGDAYLRHHREWSHSLPAMLLWPAAIGSAAAWAFGVWEHLPTICLWTFAAVVLHILFDWTNAYGVKLLLPFKRKWYHLDALCLTDPMLMGMHGLIVVGWAVGLWSNPARLCLWAWAITAVYAGWRIVHHRLVLRRVRRRFRKALAIHVLPGLWWFRWSYVAETPEGFEMGGIAGKRMLPAMKLPAAQIHECVNATLRSSAVKTLRLFSKRTYFSWNREPDGGYLVTWTDLRFWREKDWPYRAEIRLDGQLNVVDQSIGWYKKMWEAPYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0U4</accession>
    <name>A0A398D0U4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">INTEIN_C_TER domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_03065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05121">
        <property type="protein sequence ID" value="RIE05121"/>
        <property type="gene ID" value="D3H35_03065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017457846" description="INTEIN_C_TER domain-containing protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="2019"/>
        </location>
    </feature>
    <feature type="domain" description="INTEIN_C_TER" evidence="3">
        <location>
            <begin position="1954"/>
            <end position="1978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="2019" mass="228071" checksum="1051C5E902D5EFE6" modified="2018-12-05" version="1">MKNRLSQKIIISFLFAVVLIQSSLPFGNVYAASSNSKVLSVNGLKEVPVDDKAEINPFEGKEITITDKDTKDELAHKVSASKSKADKDRQTAKQNLSSDIYKIGAYYYPDFFETLTDTEKLEVLDWNYDIVQQKMAALSNKQKQQLKSYAPIAYEAYSSTLPEVKAKSSSLTEKQEQAYREHVRNIMKDSQDQIEKKTKELRQANPGKVKTSKSNERGEVRTLASSQYTINEQKTEYNYKVNSGEVVDPLYRTANQKSVDLFLNGKKGLDFSLVRTYNSMNSKLFSPQMIAYYSDNVYSQGSHNYTTSINDLVIASDPNFIATGWSLNIPTMSVQYIEADLNSIRRTNACASSTSTEGSCESVWYIFFPYKVDGVDKGYNKVTFQLDNGDSVEFKDFYGAIGSSDYTKKTLSATEYPYQNVTAYKQRIASDAVEYVISIDNEVFYTFDASGKIKSKKNEYGDQITYTHTENVLIIKDSYNRDIVIQRNLTTKNVMGFSASIGSTAIKSGQYVVERKMKDSALLKHFGVDTYIANSPYWTLNSVTYTVKGETKTIASYTYKDLSLDTVADFNLGPQGYYYYAQSDAEATVQHPFCSCTKGQNNVILWNNDGIVNNFFETVQVETRRAETYGETMYLLLNTVTLYNGLEIQYTYDKYNRAWSTISLTTIGNREQTRGTTRLFMDQFALQYISYHAVNQVNYKYTQDGVTKVLTDTYASYNKVKNYPINEVLKSHNSMYGDTNYRLHLATRYGHQQIIETRSPGTESGKTRSAYQKFEIHDNIAKFRHMNLTETWTEQGTDYNPFSAIDTANQIQYENDNKASTFYGYDYDGLNLTSVSNKGSVNSLGTLVQDTTYDTWGKVLTEKDAKNNTVTYEYNGPNHHLSKKTQISADSAYKGIEEYEYYPANDANVNRRNELKKTTITQQYPDPNLTGVIKSDTITTEFLDYNANRQVLSIRESSSGAQFGQSSVNTESEFTYTTVGQVDTEKVKVTLKEGNPQSNVIVDYDYDAQGRVIKKTYPDGNYEEFEYDALDRTKLYRVKPVNKPERVTAYTYSDSSRTFTTLNPDGTESISTFTPFGLEIKQQVKKDTDIRLMLVNDTYDGLNINKSKPYGDAAYATTYTYDSLGRLKTTVNPAAETTTYYYSNSAKNLVTNKSTLQNTVKVVQPDGKEEISYYNPLGELVKATATTPDAAKNIVATYTYSKLGQLLEQKTTSGGIAQTTKFAYDSFGNLIKVNDAEGQSYSYTYDRMGNLIRSKTGTKTTSYSYNETGWRMKSLETDEAPQTYAYKINGLVDYYVDANGKKHQYEYSTAYQVEAYKVYNGSNQLELSETYQYDPVTYLVSNETNSANETIGYVYDKWGNLDTFTVASRVYDVNYDSNLRFNSLKYPDQSEVLYTYDTSNRINSVSYPGMGTITYAYTKGSNNSSYTIQYPNNNKQVKQYDAFGSVTAMKSYLNNSTTPNWSESYGTDGFGNVKTIQNGSATRTFQYDALNRINSETASSGQLTYTYDDMGNRSSLSDSGAVPSAPAGIESLSTYTAKNQLATYANNGVSSQYTYYPNGLRATKKVGNETTRYVYLDGQIIEELDGSGNVKARNVWANELLYRQDNTTNQQGYYYYNGHGDVVSIKDGNGNPLNSYEYDTWGNFTSKSETMSNPFTYTGEVYDNETGYIYLRARYYDPSIGRFISKDTYEGQLDNPLSLNNYTYVHNNPLINIDPTGHYCVSADGMNAHSGLCKDDSNKPTRQITKDTSMINALPYIVDGVVKGYYNTEGNLVMFPEDKWANQTFWSIISEKEYNDLYVLYASYSGSPPPTTNTWNNSNVSPGLRYNSGKSGGKSNVKVVNPCNCFTAGTKVQTDEGEKNIEDIKVGDKVLSKDEKTGDVAYKEVTDTFNHETDEIYSIQVGGQTIESTFNHPFYVKETGWTFVKDLKVGDLLVQSDGNTLKIDSIELEYKHVTVYNMTVDEFHTYFVSDLGIWVHNTNKCTFRDVSKLSSWTKTTNGPKGALKEQGLRLLREKYVVMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1C2</accession>
    <name>A0A398D1C2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_03285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04974">
        <property type="protein sequence ID" value="RIE04974"/>
        <property type="gene ID" value="D3H35_03285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="15"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="277" mass="30380" checksum="268647ACB481870E" modified="2018-12-05" version="1">MVDGYPILLPEHASLDVADAELGVEGLKPSLGKEVLEPFDLQAQPGSFTAIVGPSGSGKSTVAKLAAGLLFPTWGEVSIGGLNPLHDAEHARLKVAYVPQISFLFPGTVRENLMIIRPSASDEELLEAVRIAQAQEFIEALPNGYDTSLREYGNLLSGGQKQRLAIARAMLADRPIWIFDEATSALDMETEYKIMQEITKSAKEQGRTLLMIAHRLTTVQDADRIVVMEHGCIVQQGTHQELLNGESDLYRRLWGRSADTQTGRIARKEYIDVANVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1N1</accession>
    <name>A0A398D1N1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_02840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05084">
        <property type="protein sequence ID" value="RIE05084"/>
        <property type="gene ID" value="D3H35_02840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="218" mass="24244" checksum="D7B9FEC3FA387C27" modified="2018-12-05" version="1">MSRWIDLTGKLEDGMWNYGAPFPEVVIEKVADAALFGYEGHAFQLHSLAGTYLETANHLFPDRERLGDVSIDRLKTRAWVAQLPNKRPFESIGAAELEEAVGSVLEPGDALLIATGWDAYWNREGFTESSPYFEPEAMEWIIARDVGLLGMDITSIEDPRKPGGEMTLLARYYAKDRLMVAPLVNLREAGRGPWTLLALPLHIPDACAAPCRAVLFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D2L5</accession>
    <name>A0A398D2L5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000011">
        <property type="protein sequence ID" value="RIE05314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05314">
        <property type="protein sequence ID" value="RIE05314"/>
        <property type="gene ID" value="D3H35_01170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="69" mass="7776" checksum="7D72125900D24CF0" modified="2018-12-05" version="1">MNAQVPQGFDANIYGIQLVNYTQDKSGNPSTKRIILFAQTLRFLYPTSARLIRKPKEGFFPTPWAGPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBL2</accession>
    <name>A0A398CBL2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00546">
        <property type="protein sequence ID" value="RIE00546"/>
        <property type="gene ID" value="D3H35_27795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018513">
        <property type="entry name" value="Cell_synthase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39083">
        <property type="entry name" value="PTHR39083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03170">
        <property type="entry name" value="BcsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="425" mass="45919" checksum="1AB6AB491694DE8D" modified="2018-12-05" version="1">MAGQREIRDGSVRPVEGCGPAGKRIVGETPSPWNAKNTMMLVSGTGKQLANAATILTTDTLYAQLRGSYSVIPEVLTGNVASSDSNAASDNSKALTLEQLGYGNLVTAEVLQGASSINYPIPNNWDLTNGALLHLSYKHSKSISYDKSVMTVKLNGVPVQSVKLGKATSDGGTLDVPLDPTVIGTNRTLSVEIGFQFVNGSDNTASAAASSFCSDTLLGNWAVVDKSSYLTFTPSDRLTYNLDSLPYPFVAGDEWNSTTILMNNRGSEELSSAISLINRMDTVITDRSDFQLADIASGQLQDKLKDRNVIFVGSSKELPDFLNGYDNSYVIFSPDAVQSISDKAEILAELTKKSTILQLTSSPLNPDRSVLLLVAPDRNRLLSMGKIWTDVEKSNQIRGRLVVIDEREQVYSFNDTIDARKPSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CC05</accession>
    <name>A0A398CC05_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17945</name>
        <name evidence="1" type="ORF">D3H35_29285</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000059">
        <property type="protein sequence ID" value="RIE00313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00313">
        <property type="protein sequence ID" value="RIE00313"/>
        <property type="gene ID" value="D3H35_29285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02568">
        <property type="protein sequence ID" value="RIE02568"/>
        <property type="gene ID" value="D3H35_17945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="133" mass="15182" checksum="DAB4CD342EFFC299" modified="2018-12-05" version="1">MKKIIGGTHVQVQLVVCDKIKIEEKRHILGKVINSITIPVFPYIVKFSVLIKISNIPTDQDVLTEFKVVNGLGQQISSPSNYVHRNYRDSKHIPGVDQNFDFTLLVECEENIFLECFINGNKKSYYPINISLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDN9</accession>
    <name>A0A398CDN9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Metal ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_26520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00750">
        <property type="protein sequence ID" value="RIE00750"/>
        <property type="gene ID" value="D3H35_26520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="266" mass="28125" checksum="30E60A919FFD4191" modified="2018-12-05" version="1">MDILSAEFFQRALIGGALIAVTAPLMGLFLVLRRLAMIGDTLAHVSIAGVALGFLLGVYPVAMGLVFAVVASFGIEWLRKSYKTYAELSIAIIMSGGIALASVFFTLGMGFNLNVNSYLFGSIYTLDGTDLLVIAAVTVVVLAVVLIHKKEMFLLTFDEDAAAVSGLPVRYFNIMISILTALVISAAIKIVGALLVSALLTLPAAISLALSRSFKQSIIIVVIVGEIAVLSGLWIAGIWNLAPGGTIVLLLIGILILSLTMRRTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDU6</accession>
    <name>A0A398CDU6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="6">1.2.1.88</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pruA</name>
        <name evidence="6" type="ORF">D3H35_23580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01356">
        <property type="protein sequence ID" value="RIE01356"/>
        <property type="gene ID" value="D3H35_23580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:1-pyrroline-5-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07124">
        <property type="entry name" value="ALDH_PutA-P5CDH-RocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005932">
        <property type="entry name" value="RocA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01237">
        <property type="entry name" value="D1pyr5carbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="52"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="515" mass="56134" checksum="77648D6EC733918F" modified="2018-12-05" version="1">MLEAFRNEPFTDFSPAHQAQAFKEALKRVEKELGREYRPIVGGERIDVDRFAPSVNPANPKQVIGIVGQADRELAARAIREASEAFRTWSRVPGSERARYLYKAAALLRRRKFEFSAWMVYEAGKSWVEADVDTAEAIDFMEFYAREMERLEERQPLYRIVGEDNELTYIPLGVGVVIPPWNFPLAIMVGMTTSALVAGNTVVLKPASPTPVIAAKFVELLHEAGLPPEAVAFLPGSGGEVGDALVEHPLTRFVSFTGSREIGLRINEKAAKAQPGQRWIKRVIAEMGGKDAIVVDSDSDLNAAAEAIVVSAFGFAGQKCSACSRAIVHEAVYDEVLAKVAERASKLVVGDPTDGATYMGPVIDEKAYLSILAYIESGRREGRIVCGGGKAAGDGYFIEPTVIADVEPGARIAQEEIFGPVVAFIRAASFDEALRIANDTDYGLTGAVFSRSRAHLERARREFHVGNLYFNRKCTGALVGVHPFGGFNLSGTDSKAGGRDYLLLLTQAKLLSEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDV1</accession>
    <name>A0A398CDV1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 10">Thymidine kinase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tdk</name>
        <name evidence="12" type="ORF">D3H35_26860</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + thymidine = ADP + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 11">Belongs to the thymidine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="2 8 10"/>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00810">
        <property type="protein sequence ID" value="RIE00810"/>
        <property type="gene ID" value="D3H35_26860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00124">
        <property type="entry name" value="Thymidine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020633">
        <property type="entry name" value="Thymidine_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="PTHR11441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035805">
        <property type="entry name" value="TK_cell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00603">
        <property type="entry name" value="TK_CELLULAR_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="90"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR035805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE00810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="197" mass="22642" checksum="BCC0009AFF129AF5" modified="2018-12-05" version="1">MAQLYYKYGTMNSGKSFEIIKVAHNYEEQGKRVLIFSPAIDTRAGENLVGSRTGMTREAIPVDDHTDLYASVKEHQPSPSPKRVYCVLIDEAQFLKKHHVLELTRVVDELDVPVMAFGLKNDFQNQLFEGSYNLLIYADKIEEIKTICWHCDRKATMVIRYRDGVPVNEGDQIFIGGNEDYKPVCRRCYNEAFKPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEG0</accession>
    <name>A0A398CEG0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SpoIVB peptidase</fullName>
            <ecNumber evidence="4">3.4.21.116</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">spoIVB</name>
        <name evidence="4" type="ORF">D3H35_26325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.116" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00835">
        <property type="protein sequence ID" value="RIE00835"/>
        <property type="gene ID" value="D3H35_26325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014219">
        <property type="entry name" value="Pept_S55_SpoIVB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008763">
        <property type="entry name" value="Peptidase_S55"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05580">
        <property type="entry name" value="Peptidase_S55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02860">
        <property type="entry name" value="spore_IV_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51494">
        <property type="entry name" value="SPOIVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017178232" evidence="2">
        <location>
            <begin position="28"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S55" evidence="3">
        <location>
            <begin position="196"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="437" mass="46728" checksum="4574B0BEF9CC056B" modified="2018-12-05" version="1">MKRRLIGLVAVLILAVIVSSAPIRHFASFPSTLRMFQGQAVHLDYAMPVHAEGSLNSDVATVNGSSMGTFPINLNKPLSIQPKRSGVSELKLKLFGKIPFKTVKLQVVPDLRVIPGGQTIGVKVKSAGIMVVGHHLVETAPNTKISPGEEARLKLGDLIVEINGKPLNDVSKVAGIASEAGQSGKSLALLVQRGKEKFHTTLKPAYDQEDKAWRLGLYIRDSAAGVGTLTFYAPDQGVYGALGHVITDMDTQTPIVVGSGEILQSKVTSISKSQNGEPGEKRAIFVKEGRTLGNVERNTPFGIFGKMSEMPGHAYHAEPMPVAFAEEVKEGPAEILTVVGGQTVERFAIEIVHVSKQAKPATKGMVIRVTDPKLLEQTGGIVQGMSGSPILQNGKLVGAVTHVFVNDPTSGYGCYIEWMLQDADIMLSPEQETSKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEK9</accession>
    <name>A0A398CEK9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000061">
        <property type="protein sequence ID" value="RIE00292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00292">
        <property type="protein sequence ID" value="RIE00292"/>
        <property type="gene ID" value="D3H35_29405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="78" mass="8384" checksum="7AAD7D6A8A4D7A0A" modified="2018-12-05" version="1">MVYSSDGMLSRDGTRFAFRSSMMNMVSGSERSKWGCMSADRRDRPSASWPAGSSLTASDIGKTSVKLTWTPAERAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEV4</accession>
    <name>A0A398CEV4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01706">
        <property type="protein sequence ID" value="RIE01706"/>
        <property type="gene ID" value="D3H35_12905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="147" mass="16919" checksum="6BF3AF0E529644BF" modified="2018-12-05" version="1">MTVGENEIISTREFDAPRELVFRAWTTPDLLARWWGPQGFTNTFHECDIRPGGAWRFIMHGPNGVDYPNHSVFVEIVPLERIVLDHLSGHEFRVTATFEGLEGGRTKVAFRQLFKNTEEFEQAKTYCVEGNEQNFDRLGELLAELAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFA7</accession>
    <name>A0A398CFA7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Flagellar motor protein MotA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">motA</name>
        <name evidence="10" type="ORF">D3H35_23005</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MotA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01260">
        <property type="protein sequence ID" value="RIE01260"/>
        <property type="gene ID" value="D3H35_23005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000540">
        <property type="entry name" value="Flag_MotA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01307">
        <property type="entry name" value="MOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="9">
        <location>
            <begin position="103"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE01260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="269" mass="29629" checksum="8256B4E690E073A2" modified="2018-12-05" version="1">MKNSTVIGLFLGFFALIVGMYLKGAPLTSLISNPAAYVIIIIGTCASVFMAFPMKDIKNVPKLFKITFVEPKLIPRQSIIRMFMEWATITRREGLLALEARVEEIEDPFLKSGMRMIIDGNDQDFVRDVLLEDISATEERHRAGAQIFSQAGMYAPTLGVLGAVVGLIAALGNLDEMEKLAHAVAGAFVATVLGIFTGYVMWHPISNKLKRLSKREIELKLMMVEGLLSIQSGVSTIAIQQKLMVFLTPTERIAFSEKEESGNEQKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFB2</accession>
    <name>A0A398CFB2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage 0 sporulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01413">
        <property type="protein sequence ID" value="RIE01413"/>
        <property type="gene ID" value="D3H35_23890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="1">
        <location>
            <begin position="61"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="266" mass="29570" checksum="BC4FAE1561EC1539" modified="2018-12-05" version="1">MYEVVGVRFKKAGKIYYFDPAEHPVSRDQHVIVETARGVEYGKVVVGPKTVGESDVVLPLKKVIRIAGDTDARAVDENRSAAKNAFTVGLQKIKDHGLKMKLVDVEYTFDRNKIIFYFTAEGRVDFRELVKDLAGVFRTRIELRQIGVRDEAKMLGGIGPCGRVLCCSSWLGDFEPVSIKMAKDQNLSLNPTKISGLCGRLMCCLKYEHDNYESAKEELPAVGRFVVTSMGDGKVVGINPGSRTVHVQVFEIGKVKELPFDDVVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFR7</accession>
    <name>A0A398CFR7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metK</name>
        <name evidence="17" type="ORF">D3H35_14830</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02036">
        <property type="protein sequence ID" value="RIE02036"/>
        <property type="gene ID" value="D3H35_14830"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="7"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="129"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="248"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="179"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="245"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="260"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RIE02036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="400" mass="43701" checksum="BB46D62BCBC4CB20" modified="2018-12-05" version="1">MSIKGRHLFTSESVTEGHPDKICDQISDAVLDAFLEVDPYARVACEVSVATGLVLVIGEISSKADFVDISSIVRRTIKEIGYTRAKYGFDSSTCAVLTSLNEQSADIAQGVNAALESRDGKDIKQENEDIGAGDQGLMFGFASNETPEYMPLPIALAHRLSRRLSEVRKNGTLDYLRPDGKTQVTIQYEDGKPVRVDTIVISTQHDEKITSEQIDSDIRKHVIAEVVPTEWLDAETKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGAFSGKDPTKVDRSAAYAARYVAKNIVAAGLADKCEIQLAYAIGVARPVSVNVDTYGTGKVDEEKLVELIDANFDLRPAGIIKMLDLRRPIYRQTAAYGHFGRTDLDVPWERLDKVEALKKGALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFW2</accession>
    <name>A0A398CFW2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01390">
        <property type="protein sequence ID" value="RIE01390"/>
        <property type="gene ID" value="D3H35_23770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="66" mass="7946" checksum="32CB936E43848F1A" modified="2018-12-05" version="1">MYMNGQMIFDDNHFMDHMVSEVPIQVYCGRMHSDVGFIEYYGKEFVKVNNIFYSRKQFTFVSRPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGM9</accession>
    <name>A0A398CGM9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_25055</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01615">
        <property type="protein sequence ID" value="RIE01615"/>
        <property type="gene ID" value="D3H35_25055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006061">
        <property type="entry name" value="SBP_1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01037">
        <property type="entry name" value="SBP_BACTERIAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017197870" evidence="5">
        <location>
            <begin position="30"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="452" mass="48904" checksum="8F39D937DAE7EDEF" modified="2018-12-05" version="1">MNKKWMSMATATVVFSVLLAGCGGNNEKSSPSAEAPSSANASESPAAETGKPVKLTLLNGTVEAVDWLNEQIKAFSAANPGITVEQEFQKTASDVLKVKIASGDAPDIVALAQVPQEFYDQDLFHDFSGDSAIWDRLTNPTIKQSIADTNRSDKQFYLPMTVSYTGLYYNKDIIAELGIQRPDSWEAFSQALKSVKEKKSELTPLYLGGKDSWTLGQLAQFLPLGSIQQSLGIEEANKAFVANDAAKLELDKADGRLETFAKAIMDLKSAGLINKNAASASYDNQLDAISNGKAAFVIQGMWALGDIQKKNPNAPIGFWPIPALVPGDKPYMIGGADGAVSVSEKSANKEAALKFVEFLMSPDVQKSYSTLRNSPSVYKDASADWSILSKDVAEDQQVAFVASRWPWTPSGYNSDAIGRTVQELLVGAYKTPADFAKTFKENWDKGYTDVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGP6</accession>
    <name>A0A398CGP6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_29905</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. EmrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00249">
        <property type="protein sequence ID" value="RIE00249"/>
        <property type="gene ID" value="D3H35_29905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="23"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE00249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="489" mass="52335" checksum="FCE62DCCAAA58D6B" modified="2018-12-05" version="1">MNAAGAETSASSRDLSGIKRGPIVAALIIGAFVSILNETLLNIAFPDLMTQFGISAAKVQWLATSYMLVIGILVPITALLQQWFTTRQMFLGAMTLFLAGTVICSVAPSFEVLLVGRVVQALGTGLMLPVLMNTILAIFPPENRGGAMGMIGLVIMFAPAIGPTLSGLIIDWQDWRWLFYLIIPLTVFSILFAAAFLKNVSDLTRPKVDILSILLSTIGFGGLVYGFSKAGEASWSAPEVFWCLIAGGVGLLLFILRQLVVKQPMLDLRAFKYPMFSLVTVLMLVLMMSLFSTMILLPLFLQNALLMTALAAGLTLMPGGVVNGIMAPISGKLFDKFGPRVLVIPGLALVCAATWLFTQISASTTSGYIIFVHIVLLIGISLVMMPAQTTGLNQLPRHLYPHGTAIMNTLQQVAGALGTALFVSIMSSGSKSYLKTSENPTAPAELVNGLVAGMKDAFYIGLWISLIALVIGLFIKRAKAPQDEVKQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH92</accession>
    <name>A0A398CH92_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_13640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01830">
        <property type="protein sequence ID" value="RIE01830"/>
        <property type="gene ID" value="D3H35_13640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="200" mass="23015" checksum="F5C9C148C5EEC443" modified="2018-12-05" version="1">MQKRGGIRHPQLLFPAVGWQFEEIRHLQLLFPAVGRAFEEIRHLQLLFPAVGWAGVEIRHLQLLFPAVGWAGVEIRHPQLLFPAVGWADAEIRHPQLLFPAVGWQFEEIRHPQLLFPAVGRADAEIRHPQLLFLAVGRAFEEIRHLQLLFPAVGWADAEIRHPQLLFPAVGRAFEEIRHPQLLFLAVGRAFEEIRHLQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHI5</accession>
    <name>A0A398CHI5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_24145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01452">
        <property type="protein sequence ID" value="RIE01452"/>
        <property type="gene ID" value="D3H35_24145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="2">
        <location>
            <begin position="15"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF_2" evidence="4">
        <location>
            <begin position="296"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="477"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="539" mass="61308" checksum="4C2A37CC973D14D0" modified="2018-12-05" version="1">MDDAIREGFSVKALFDVPHFKDAVLLGGSAGLDSLISRINVMEVPDVIDWVRPGELLMTTGYPFKHDPGLLVPLIEQLAQKGVAALGVKTKRFFDQIPEAAIEAANRHGMPLIELPPGTTFSDVVREVMERVLISESKDLSILQGRVQGLSHVLLHGDGLPAFLTHLQAMIRNPVILLDPHNQRTASPDAEPLCRLVEESEWNKFRTDQMLETNVLQIGERSVRVHVAAVPDGQFRSYLLLILEDTTDYGTVDSLTVNWAGRLLGFEISNMQARKNIEVKYFDQFLQDWLAGRIVSVVDLRLRAEACGWPLADDASYMAGIVSFRERKPDVKALQELAKRLNWESVTRRCEVKWTVLEGELVALFTLRGEDSGDEARRQLTGSVWNFMRPMLQEKRASLCLGREAKSQGEVAGSYRDAKRTTDIRRVCQLKEETVRYGELGIYMLLYRLQGTEELEEFKRLYLHPLLELDRKQQGALLNTLRTYFECNCNAKETAEQMFLHYNTINYRLDRIKNELGLRLDDPETKLLLQLAIRSNDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHV7</accession>
    <name>A0A398CHV7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02836">
        <property type="protein sequence ID" value="RIE02836"/>
        <property type="gene ID" value="D3H35_19595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="299" mass="32988" checksum="0A257222F230BBCE" modified="2018-12-05" version="1">MVGPVTNYASGQQMIPVGYTDLKDLNAFARAYAESKRGQSFEVRRLVGFCLLVKRHVMEEVGGFDERFGLGNFEDDDLCLRVRNRGYQLRVVEDCYIHHFGHMTMSILQGTNLMELLGLNRIKAREKWGEDIIGLIYREPATISLVLMVRSGGSVAHRTVEAIGSHADEIVAWCEDDSEDARCALGAYTNRIADTLENAMALATRDFVLAIYADEEWDEEALRLLTGLKVAVGSGTEAVELLVVRATAESGDLAAGVRRCRLARRSAGLRWNGVTGEFIVRSGAAVETSGITIRSTRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHX2</accession>
    <name>A0A398CHX2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000054">
        <property type="protein sequence ID" value="RIE00488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00488">
        <property type="protein sequence ID" value="RIE00488"/>
        <property type="gene ID" value="D3H35_28130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="198" mass="22513" checksum="7CA5702272489F7E" modified="2018-12-05" version="1">MGIMRRLYRGFIDLKIQDKIFLCFVVVIIASVLGIGISSYYKSSAIFGKKTSRYNVETVQQISTSVDYTLERIDDLSGILAFDQTIQRVFKHGYGRMSERETIAAVNEIESIMITHYNSQIMRSIEIYGNNGLVVKVPSSFNEQGNGPTPKQFVEMASVYRAKNEVAERRQEHGLLYAVREINSCRRRSNRLAPSLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI07</accession>
    <name>A0A398CI07_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose pyrophosphorylase</fullName>
            <shortName evidence="9">ADPGlc PPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glgC</name>
        <name evidence="11" type="ORF">D3H35_26675</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="9"/>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00779">
        <property type="protein sequence ID" value="RIE00779"/>
        <property type="gene ID" value="D3H35_26675"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00624">
        <property type="entry name" value="GlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023049">
        <property type="entry name" value="GlgC_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02091">
        <property type="entry name" value="glgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="10">
        <location>
            <begin position="8"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha-D-glucose 1-phosphate binding" evidence="9">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE00779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="388" mass="42759" checksum="F1E7AB7CB330E414" modified="2018-12-05" version="1">MRRNECIAMLLAGGEGRRLGVLTKDLAKPAVHFGGKYRIIDFTLSNCVHSGIETVGVLTQYQPLVLNQYLGIGSAWGLDRREGGMHVLPPYVRQKGGVWYKGTANAIYQNIGFIERYEPEYVLIISGDHIYKMDYDKLLDAHKKTEADATIAVISVPWADASRFGILSVDEEDRIVEFAEKPKKPNSNLASMGVYMFSWPVLRDALLRDEAERGSTNDFGKDIIPTLLAEGKKLYSHRFDGYWKDVGTIESLWEANMDLLEDEPALQLNDRAWRIYAAGPNRPAQYVSPQAKVRSSLVNEGCFVEGDVNRSVLFQGVRIGEGSFVEDSVLMPGAVIGKGARIIRAIVGENAVVGEGCQVGSIDSDEIAVVGSGETISNEAELQEVEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI68</accession>
    <name>A0A398CI68_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02140">
        <property type="protein sequence ID" value="RIE02140"/>
        <property type="gene ID" value="D3H35_15405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="156" mass="18204" checksum="277414F4C8997DE2" modified="2018-12-05" version="1">MLSFEEKLAIAGSFPELQRKDVSLGRVNYHYEDSAYEKKTVVYHLHPNGNGFVYAGHLDDCPFDIDDKGFVNIREFAADDFRALIAESIRSLTDEFAANEPSREERWTNEKKQTLELKFEEEDEMWYIYSGLNLDAVFDTYEEAKEYLVDEGFSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIC9</accession>
    <name>A0A398CIC9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000051">
        <property type="protein sequence ID" value="RIE00598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00598">
        <property type="protein sequence ID" value="RIE00598"/>
        <property type="gene ID" value="D3H35_27450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="188" mass="20673" checksum="B96E5462052607D2" modified="2018-12-05" version="1" fragment="single">MYLDSKATSSNIRQAIRYMLSISEPGDVACLYFSGHGGLHSITADTYYQTIIPYSGSYISDWDLALAAESLEPSKVNFTVILDSCQSGGMHEESEHPDAIKSVRYASDFVNRLIASLQKVIPFGVTVPNVQAYSSNVNNVRQGDAALVCMDEDPNQLFIPLAKSTLLSACRWDESAGEPKFRRPQPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIH0</accession>
    <name>A0A398CIH0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">tatC</name>
        <name evidence="6" type="ORF">D3H35_25725</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms a complex with TatA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00989">
        <property type="protein sequence ID" value="RIE00989"/>
        <property type="gene ID" value="D3H35_25725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019820">
        <property type="entry name" value="Sec-indep_translocase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01218">
        <property type="entry name" value="TATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="254" mass="28904" checksum="D40FEC6E3643C7EC" modified="2018-12-05" version="1">MPESQEEWMPILEHIGELRKRILFCLIVFVLGLVGGLFGAQPLFDYLVAAAPVDNLELNAFSPWDAIGLYMKFAMLISLLVALPFAMFQLWAFVKPGLARKEQSSTLRYVPGTLIMFLIGLAFSYYVVFPMAFYFTENVTHSMGLQQMYGVTQYFSFLFNILLPISLLFELPVIILFLTRLGILQPRLLQKMRRYAWFALIVIGVIVTPPDFVSDSLVAIPLILLYEFSVMLSRIAYRKKLSAKSAEEEDDSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIQ0</accession>
    <name>A0A398CIQ0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trxA</name>
        <name evidence="7" type="ORF">D3H35_14365</name>
        <name evidence="8" type="ORF">D3H35_14415</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01952">
        <property type="protein sequence ID" value="RIE01952"/>
        <property type="gene ID" value="D3H35_14365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01961">
        <property type="protein sequence ID" value="RIE01961"/>
        <property type="gene ID" value="D3H35_14415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="28"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="103" mass="11213" checksum="96D9609140DFFB68" modified="2018-12-05" version="1">MAVAVTKDSFNETVAQGVSLLDFWAPWCGPCKMQLPIVEELSEELKGQATIGKINVDEEPEIASQFGVMSIPTLILFKDGQPVDKLVGLQSKEALKSRIASHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIS0</accession>
    <name>A0A398CIS0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00758">
        <property type="protein sequence ID" value="RIE00758"/>
        <property type="gene ID" value="D3H35_26565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019673">
        <property type="entry name" value="Spore_germination_GerPC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10737">
        <property type="entry name" value="GerPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="213" mass="24117" checksum="257D66F416AF5B1A" modified="2018-12-05" version="1">MSNAWNWSPYTQEWADLLLRLQQSEQLVQQLGDQLKQLQKELSDLKAKPPLHIEYHFDQLKVNRLEGTLNVGLSPQGIGGIDSFDTPATGCWNVVQESKPASDDAQIEAIQGEMARYMDETAFGALQGLEQSLGIPLDAAHRQKVVEDVKGQLNDRVRYYAKTAAYPAEGTDEARQKWRSDIEQKTYRDIQSAFSAYLTKLKQTRSQRSDSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIS1</accession>
    <name>A0A398CIS1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_22025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01099">
        <property type="protein sequence ID" value="RIE01099"/>
        <property type="gene ID" value="D3H35_22025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="124"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="242" mass="27029" checksum="7DE87162D3F5C812" modified="2018-12-05" version="1">MSGGQRQRVAIARAIIRDPAILILDEATSALDPATESAINATLQRLTADRTVISVTHRLASAEHADCIYVLHQGEIAEQGSHQQLLQLPAGRYKQSWQKQTGFDISEDGYHVEVSAERLKLFPIFSEMEDSFLREISSFFATESYAKDRTIIHEGDPGDKFYVIVRGKVEVLKSDEQGNEARVAVLSDGDFFGEVALLRNVPRTASIRTLTPVVFVTLQREFFQDLLKKAPHLAAVMEDRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJJ0</accession>
    <name>A0A398CJJ0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Quinolinate synthase</fullName>
            <ecNumber evidence="2 9">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">nadA</name>
        <name evidence="11" type="ORF">D3H35_23480</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate</text>
            <dbReference type="Rhea" id="RHEA:25888"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="2.5.1.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the quinolinate synthase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="2 9"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01339">
        <property type="protein sequence ID" value="RIE01339"/>
        <property type="gene ID" value="D3H35_23480"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00568">
        <property type="entry name" value="NadA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023066">
        <property type="entry name" value="Quinolinate_synth_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="122"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="207"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE01339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="312" mass="35138" checksum="A8EE977BF959211A" modified="2018-12-05" version="1">MEALALERKAEQNRELRERLLQLKKERNAIILAHYYQRDEIQEVADFRGDSFLLAQKAAATDADVIVFCGVHFMGESAKILAPHKTVLVPDERAGCPMADMVNPIGLRELKAKHPNAKVVTYINSSADVKAETDICCTSANAIKVVNSVDSDEVIWCPDKNLGHYVAQHTDKKMIIWEGYCNTHDMLTVKDVVEMRAKHPNAQFVVHPECRPEVVEMADFVGSTTGILKYCKESDCKEFIVGTEDGTGYQLRVDSPDKTFHFASKFLVCPNMKVNNLKKVVRALETMQPQIYVPEDVANKARLSLERMLLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJR0</accession>
    <name>A0A398CJR0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NlpC/P60 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_21890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01078">
        <property type="protein sequence ID" value="RIE01078"/>
        <property type="gene ID" value="D3H35_21890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017288846" evidence="2">
        <location>
            <begin position="32"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="28"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="164" mass="17804" checksum="219A82563959882E" modified="2018-12-05" version="1">MGRGLPVLRKVSALLLGLVFVLAFQVGSAFASSKLDDTIDKLIGIDYKYGGTTTKGFDCSGFTGYVFDKLGIDLPRSSRDMFGWDGGTKVDRDELRAGDLVFFNTSGSGVSHVGIYVGNNKFAHSHSAGVAITSMDDKYYAKRYLGARRVMSTETYKKLATEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJR4</accession>
    <name>A0A398CJR4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_23920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01419">
        <property type="protein sequence ID" value="RIE01419"/>
        <property type="gene ID" value="D3H35_23920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000310">
        <property type="entry name" value="Orn/Lys/Arg_deCO2ase_major_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008286">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036633">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01276">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03711">
        <property type="entry name" value="OKR_DC_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55904">
        <property type="entry name" value="SSF55904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OKR_DC_1" evidence="3">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="OKR_DC_1_C" evidence="4">
        <location>
            <begin position="191"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="258" mass="28338" checksum="BEDD8DF6BA261DB2" modified="2018-12-05" version="1">MLSAMTMGAMIHMQGDLLDRESIRQALRMVQSSSPSFPILASLDLARRQLQVEGAEAFSQALRALDTVLDKLAETPFRNLGAGKYRNKAVAYDPLKLVLFDETGMLDGFSLRDELGKRGCVAEMADSRYVVLAFGTGSIPEDGDALIQALFDIAGSFKITTVRASKVRSEEYRLSEEIPAPIVFRRKMPPSEAIPLEESAGRIAAEWVIPYPPGIPVLFPGEEIQPSAVNQLIQWRAKGAQIQGAEDSSLCRVRVLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJV0</accession>
    <name>A0A398CJV0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02625">
        <property type="protein sequence ID" value="RIE02625"/>
        <property type="gene ID" value="D3H35_18255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="64" mass="7270" checksum="EE486D8B3AAE4451" modified="2018-12-05" version="1">MLIDDYSAFRIWECERLERERKLGIKRSAELFEPLKADAGASSKLASLLSRIFGKRGRAAQTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK51</accession>
    <name>A0A398CK51_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glucosamine-6-phosphate deaminase</fullName>
            <ecNumber evidence="2">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GlcN6P deaminase</fullName>
            <shortName evidence="2">GNPDA</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">nagB</name>
        <name evidence="4" type="ORF">D3H35_17685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02522">
        <property type="protein sequence ID" value="RIE02522"/>
        <property type="gene ID" value="D3H35_17685"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="PTHR11280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="3">
        <location>
            <begin position="19"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for enolization step" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" description="For ring-opening step" evidence="2">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for ring-opening step" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="For ring-opening step" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="242" mass="26529" checksum="AC3BB728904E58F9" modified="2018-12-05" version="1">MNILTFDSDEKLNEAGAGIITGIVQTNRRAVLGLATGGTPVGLYKYIVRDYERGMCSFKNATTFNLDEYVGLPDDHPESYRAYMRQHLFDHIDLPISQAHIPNGNAPDPEAECRRYDDLIDNAGQIDLQLLGLGHNGHIGFNEPAHALIRATHVVELAEETRQANARFFDSIDQVPQQALTMGVGTILKAKMILLVVKGADKADIVQRALRGPITTDCPASLLQTHPHLNVLLDRAAASRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK95</accession>
    <name>A0A398CK95_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="10">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">atpA</name>
        <name evidence="14" type="ORF">D3H35_14600</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="10"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03133">
        <property type="protein sequence ID" value="RIE03133"/>
        <property type="gene ID" value="D3H35_14600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="13">
        <location>
            <begin position="27"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="11">
        <location>
            <begin position="149"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_C" evidence="12">
        <location>
            <begin position="371"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="169"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="10">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE03133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="504" mass="54636" checksum="1423A161E55E768E" modified="2018-12-05" version="1">MSIRPEEISTLIKQQIQQYQSDIQVVDVGTVIQVGDGTARVHGLEKCMAGELLEFSNGVVGMALNLEEDNVGVVIMGPYTGIREGDQVKRTGRIMEVPVGDALLGRVVNALGQPVDGNGPIATTGFRPIESPAPGVMARKSVHEPMQTGIKAIDAMIPVGRGQRELIIGDRQTGKTSIAIDTIVNQKGNGVICIYVAIGQKQSTVRGVVETLRKHGALEYTIVVTASASEPAPLLYIAPYTGCSMGEYFMYNGKHVLIVYDDLTKQAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDEHGGGSMTALPFIETQAGDVSAYIPTNVISITDGQIFLEADLFYSGQRPAVNVGISVSRVGSSAQIKAMKKVAGTLKTDLAQYRELAAFAQFGSDLDKVTKSRLDRGVRTLEILKQGVNQPMSVERQVVSLYLVTKGHADDIPVQDIRRLEAEFLAYVDANRPEIFASIRDTKDLTADNDKALVEAIQAFKKSFAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKC2</accession>
    <name>A0A398CKC2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02750">
        <property type="protein sequence ID" value="RIE02750"/>
        <property type="gene ID" value="D3H35_19085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="107" mass="12558" checksum="65AF010DD23A9BC4" modified="2018-12-05" version="1">MILFCEYAFVSGEAQNDFAEWAVSSPDRWGSAELLASEVQPGLFVEIWRGLDEQSAERIRRERLEEHSEWREMDKWVKGGREGLRMWTFRPFDYRRPPVPPVPNGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKF6</accession>
    <name>A0A398CKF6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoserine aminotransferase</fullName>
            <ecNumber evidence="6">2.6.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphohydroxythreonine aminotransferase</fullName>
            <shortName evidence="6">PSAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">serC</name>
        <name evidence="8" type="ORF">D3H35_18960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 6">
            <text>2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="6">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03193">
        <property type="protein sequence ID" value="RIE03193"/>
        <property type="gene ID" value="D3H35_18960"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PTHR43247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01364">
        <property type="entry name" value="serC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="7">
        <location>
            <begin position="9"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="80"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="366" mass="40153" checksum="B77CAA2C351DB273" modified="2018-12-05" version="1">MIEGTKRAYNFNPGPAALPLEVLEQAQKEFVSYAGQGMSLLEMSHRSKTVERLNEETQELLLELLGIRAGYRVLFMGGGASMQFALVPTNLLAENKVGRYVLSGSFSEKALAEAKAVGAAEALASGKDSGWSRLPDLAGIAPKSDTAYVHITTNNTIEGSRFSTFPDLGTIPLVADMTSDILSRELDMKRFALIYAGAQKNLGPAGVTAVILRDDLLAQCSARSIPTIFNYAAYAQHRSLYNTPPVHAIYMMKLMLEWAKNQGGVTALEKRNAYKAALLYEVIDSSGGFYEGIVEKLFRSDMNVTWRMKDEEMEKRFVRESERNGFEGLAGHRSVGGLRASAYNAVTVEACKALADFMLDFEKRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKG1</accession>
    <name>A0A398CKG1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_23650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01368">
        <property type="protein sequence ID" value="RIE01368"/>
        <property type="gene ID" value="D3H35_23650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017363939" evidence="2">
        <location>
            <begin position="24"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="127" mass="12842" checksum="C4CC2C5C11813418" modified="2018-12-05" version="1">MRRIAVGIVLALCIFGQAASIQASAIEQPNGTSESVPTMKEEDNSVQSKAFRSGRRTYRAPRSGYTGGNRTGVAPGTNTGRTTRTPAAGTTGRFGGFFGGLTAGSLLGGLLNPFGFGGWGGGTGASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKL9</accession>
    <name>A0A398CKL9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ring-cleaving dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_03500</name>
        <name evidence="2" type="ORF">D3H35_13165</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000021">
        <property type="protein sequence ID" value="RIE04930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01749">
        <property type="protein sequence ID" value="RIE01749"/>
        <property type="gene ID" value="D3H35_13165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04930">
        <property type="protein sequence ID" value="RIE04930"/>
        <property type="gene ID" value="D3H35_03500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="228" mass="25807" checksum="DFD608E9A165FCF1" modified="2018-12-05" version="1">MRLKSVKLLAANLEQQKLFYTQIMGLPILDDCIDTFTIRVGHSRLTFERSTHADESPVYHFAFDVPGNRVAESIVWLSSRGISLNLLPQNKYQLISTTWNSTSIYFYDYAGNIVEFIARHNLNYSSTSPFTSNSLLNISEIGLVVSDVPSTRELLRSRFSIDGYKNNNDCSFAAVGDEDGLFILTAHNRIWLGSNKEAKIYKTEVEIEGAVTKGELIFKDYPYKIIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKP2</accession>
    <name>A0A398CKP2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02945">
        <property type="protein sequence ID" value="RIE02945"/>
        <property type="gene ID" value="D3H35_20275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017433370" evidence="1">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="68" mass="7649" checksum="0E68335562FBB408" modified="2018-12-05" version="1">MKSVLSRRSLKLGSAALLALLLAWGTMLVRASADNWTDHADTDWYLNYADYTTFTIDSPPSWRESPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKP9</accession>
    <name>A0A398CKP9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class A beta-lactamase-related serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_13335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01779">
        <property type="protein sequence ID" value="RIE01779"/>
        <property type="gene ID" value="D3H35_13335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017402270" evidence="1">
        <location>
            <begin position="36"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="49"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="279" mass="31054" checksum="FE0E9137AE7D88DC" modified="2018-12-05" version="1">MAVGRKIRQWIRLRAGVMLLLTAGLFLSVMPTASADPVEWNGNDLSSFFNRFFEGRMNRTPGAVVIAVNKDGELFSHGYGFADKERKRKVDPDQTAFRVGSVSKLFTATAVMQLAEQGKLKLDEDINNYLPFRIHNRPGHPITLAHLLTHTAGFDETALIFNWNWPPPEDADLGNFENTFSPPVLRDPGTVKSYSNYGISLAGYIVQRQSGVPFAQYVKENIIHPLGMDRSSFYPSAELLSRLAVGYDAHGLPIREMALNSAYVPAGDCTRQLPIWAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKX2</accession>
    <name>A0A398CKX2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_03585</name>
        <name evidence="2" type="ORF">D3H35_13870</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000022">
        <property type="protein sequence ID" value="RIE04920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01869">
        <property type="protein sequence ID" value="RIE01869"/>
        <property type="gene ID" value="D3H35_13870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04920">
        <property type="protein sequence ID" value="RIE04920"/>
        <property type="gene ID" value="D3H35_03585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="170" mass="19285" checksum="7E29399F8ADCC676" modified="2018-12-05" version="1">MIREALERDLPAILDIYNDAILNTTAVYTYEAQTLSQREQWFCEKREAGYPVLVFEADGEAAGFATFGPFRAWPAYKYTIEHSIYAHGGYRQRGIGTALLKELIRIAEERGYKTLVAGIDESNDASVRMHVKHGFSHAGTIRNAGYKFGRWLNLAFYEYELAGPSHPVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKZ1</accession>
    <name>A0A398CKZ1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">clpP</name>
        <name evidence="8" type="ORF">D3H35_21000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03065">
        <property type="protein sequence ID" value="RIE03065"/>
        <property type="gene ID" value="D3H35_21000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00493">
        <property type="entry name" value="clpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="194" mass="21277" checksum="09D8351BDD2C2894" modified="2018-12-05" version="1">MSAYVPYVVEQTNRGERSYDIYSRLLKDRIVFLGSAIDDQIANSIVAQLLFLAAEDPDKEIHLYINSPGGSTSAGFAILDTMQFVKPPVHTICTGMAASFAAILLLAGAKGKRFALPNSEIMIHQPHGGAQGQASDIAISAKRILGVRERLNRIAADRTGQPFEKIEKDMDRDYFMSAEEALEYGIIDRVVTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL87</accession>
    <name>A0A398CL87_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CBM20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_28735</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00401">
        <property type="protein sequence ID" value="RIE00401"/>
        <property type="gene ID" value="D3H35_28735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031965">
        <property type="entry name" value="CBM26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM_fam20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16738">
        <property type="entry name" value="CBM26"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017417455" description="CBM20 domain-containing protein" evidence="6">
        <location>
            <begin position="35"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="7">
        <location>
            <begin position="1105"/>
            <end position="1206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1206" mass="128912" checksum="14AEB25F018F5243" modified="2018-12-05" version="1">MKKKGRSIWSIVLFLALVLQALNFTPITHGSASAAASEEYGLPAKTKDGVIFHAWNWSFDTIKANLPAIAAAGYKSVQTSPIQGNKENLMEGSKWWILYQPTNFKIGNAQLGNRDQFKAMCDEAEKYGIDIIVDVVANHTGNAGGGSLTYTPASNVDSAIKNNQYFWHDARGVEDWNNRWQVTHWGIGLPDLNTSNQELQNIIIAFLNDAIALGADGFRFDAAKHIELPNEDGGSNFWTRVLGSLSKQNLYIYGEVLQGGADNFAGYSNYINLTASAFGHDIIKAVGYGASKNVDKARSYNSAGVSSSKLVTWVESHDTYANDASETTAMNDWQIKMGWALIASRAETTSLFFGRPGGSGKFGTALGQAGKDLWKDADVAAVNKFHNAMVGQGEYLRTISSELMLVERGTKGMTIVNLGGDASINSVTNLASGTYVNQATGGGTFTVANGRITGNIGGGKIAVLYEAAKPTPKVSIDVQEGGFFTDSLTVKMTYSDAVSASYSLNNGTQTPFNSGNTVTFGAGAAFGTTYTLKIVANNAAGQTTQTYTFTKEDPNAALKVHYYKPSGWGTPGMYYYDDSVTPTKIGVAWPGTAMTDEGGGWYSTQVAGWKKAKVIFTSGSNQIPGASQPGYDVTGEKWIKDGVIHTSNPDVVIKTPTVSIDKSEGAFYTDSLDVTISYNDATAAAYSLNGSAQVSIASGQKVTFGAGAAYGTTYTLNVTASNADKTTTKSYSFTKTKAALPAPTISIDKAEGTFYGNSLEVTVSYANADGATYTLNGGAQTNVASGQKITIGADGAFGTKYTLIVTASNEDKSTTKTFTFTKEDPNAGLSIHYYKPSGWGTPNIYYYDDSVTPLKIGVAWPGVAMTDEGNGWYVFRVTGWTQGKVIFNSGSNQIPGASQPGYAVTGEKWIKNGVIYQSNPDIVIPENKTPTITIDKAEGAFNSDSLNVAITLKDATSATYSLNGGAPVSFTSGQQVAFGAGDAYGTTYTLSVTAINIDKTATKTYTFKKEEEQAITVHYYKPDGWGTPNIYYYDESVSPKKEGGAWPGVAMKNEGNGWYSYTLTGWSKANVIFNSNGQQIPASKQPGYLVTKSVWIKNGVITDQEPVQKTVAVTFTIKNATTVSGQNIYLAGNVAELGNWAPASAVATTISTYPTWKVTVNLVEGTKIEFKAIKKNASNNVVWESGQNHSYTVSSSNPNVEFNFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLP0</accession>
    <name>A0A398CLP0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_13330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01778">
        <property type="protein sequence ID" value="RIE01778"/>
        <property type="gene ID" value="D3H35_13330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010708">
        <property type="entry name" value="5'(3')-deoxyribonucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009206">
        <property type="entry name" value="Nucleotidase_putative"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06941">
        <property type="entry name" value="NT5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021362">
        <property type="entry name" value="UCP021362_HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR021362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="187" mass="21974" checksum="990E29655CCFE708" modified="2018-12-05" version="1">MRIGIDLDNTVLDATSAHLHYYNKASGRSLTHADVNDFYLYRLYGWNKAERDAIYNQYGHDIHWNSAPLPMAVEILQQLFNRHHLSIITARPDHFRDVTIEWLKHHKINYHHITLVENKLQECINSKVDVLIDDGPHYAEEFALANKPVILYEQPYNLSVANDLVFRASNWVEVKKHIDYLESRLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLU0</accession>
    <name>A0A398CLU0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutaminyl-tRNA synthetase</fullName>
            <shortName evidence="8">GlnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glnS</name>
        <name evidence="12" type="ORF">D3H35_06825</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04316">
        <property type="protein sequence ID" value="RIE04316"/>
        <property type="gene ID" value="D3H35_06825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00126">
        <property type="entry name" value="Gln_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022861">
        <property type="entry name" value="Gln_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="10">
        <location>
            <begin position="46"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1c_C" evidence="11">
        <location>
            <begin position="358"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="286"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="54"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="60"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="279"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="287"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE04316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="574" mass="66148" checksum="F393DBA209AF0EC4" modified="2018-12-05" version="1">MIKRYYVKIILHALRGRLVGLETKTSSSNFIKHIVAEDLASGNTKEVVTRFPPEPNGYLHIGHAKSICLNFELADEFKGRTNLRFDDTNPVKEDVEYVESIKRDVAWLGFEWDGLFFASDYFGEMYERALVLIRKGLAYVDDQTADQIRETRGTLTEPGKESPSRGRSAIENEDLFRRMKDGEFKDGEKVLRAKIDMASPNVNMRDPVIYRIVHAHHHNTGDQWCIYPMYAFAHPLEDAIEGVTHSICTLEFEDQRPFYDWVVRECEMPWVPRQYEFARLNMTNTVMSKRKLKLLVDEKAVDGWDDPRMPTISGLRRKGYTPEAIRAFCREIGVTKSYGIVDERMLEHFIREDLKLKALRTMAVISPLKVVITNYPEGQTEWLEAENNSENPEMGNRQIPFSREIYIEQDDFMENPPAKYFRLFPGNEVRLKHAYFIKCEEAIKDSDGNVIELRCTYDPETKSGSGFTGRKVKGTIHWVEASNAVPAEFRLYEPLINDDSEDDGNGSFLQHLNPNSLETLQGFVEPAMKEAPGGEKFQFFRHGYFNVDPKDTTPDKPVFNRIVSLKSSFDIPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLV3</accession>
    <name>A0A398CLV3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_26980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00827">
        <property type="protein sequence ID" value="RIE00827"/>
        <property type="gene ID" value="D3H35_26980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="83" mass="9476" checksum="FA885DB087A770B6" modified="2018-12-05" version="1">MLETDVHLSSSTSMKRLIVGGEDFSHALAQSIYEKYEGKVEIYNEYGPTETVVGCTVYLFDAGSKGIHRYRLGFLHPTYKYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMH0</accession>
    <name>A0A398CMH0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LysM peptidoglycan-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03472">
        <property type="protein sequence ID" value="RIE03472"/>
        <property type="gene ID" value="D3H35_12520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="229" mass="26224" checksum="020CBC2AACE7CE63" modified="2018-12-05" version="1">MLIRQTSILRGEGTLYPYVWQAAAPYYYVAYPMSFPCDSRIFGRSSKGCISQAESDLRNEFRMLWEEHVAWTRMLIISIASDLKDEALVTQRLLRNAPDMAAVFRRYYGDQVASRFNDLMTQHLVIADQLVKAAKAGDTAATADAEKRWYANADEIAVFLSGINPYWPKNDVAKMMHEHLRLTKSEAVNRLNQNFAADISDYDKIEQQALMMADVFTDGIVKQFPNQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMS6</accession>
    <name>A0A398CMS6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_08075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKC lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03913">
        <property type="protein sequence ID" value="RIE03913"/>
        <property type="gene ID" value="D3H35_08075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008844">
        <property type="entry name" value="Spore_GerAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038501">
        <property type="entry name" value="Spore_GerAC_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35789">
        <property type="entry name" value="PTHR35789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05504">
        <property type="entry name" value="Spore_GerAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="358" mass="41338" checksum="84F21277D324A3FD" modified="2018-12-05" version="1">MARVRSLARLDSLRRMRLQGYRQTIFRHCDRHRLNRKNRYPVPGYAKARYSLYEDRKRRGAHGSRDDRRGERRGSDSQAQKPRRQRARFCPLQSYSARQIAGRSGLRGFDRMDVPSAGHSADCLSRNRDAGCQFVIEGQNQIGALSGQRFFPYVREGRTESSFTVSEYLFDFMRRSSEPGLDPYLPIVGSDGDSYVVDRVALFDKTKLRLILTPEETQLYNIVAFQFNKSGVSMELDGKRLVMFNTLVKVKRSIDVGAEPVVNLRVRLRGLVEESPERIMNGQLVHMERRLGESVSEQIRAMLVKVRDAGVDPFGFGLSYMAKRFGRADDWKRWKEAYPNVRYRVKTDVVFTSTGQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMW3</accession>
    <name>A0A398CMW3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Baseplate protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02589">
        <property type="protein sequence ID" value="RIE02589"/>
        <property type="gene ID" value="D3H35_18065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007048">
        <property type="entry name" value="IraD/Gp25-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04965">
        <property type="entry name" value="GPW_gp25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GPW_gp25" evidence="1">
        <location>
            <begin position="27"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="133" mass="14994" checksum="C77FB3F748D67BB6" modified="2018-12-05" version="1">MSASFLGRGWKFPVQVDKTTGRFLLSEGEDDIAEAVRVILMTSKGERVMRPSFGCGLRDFAFGTMDETSLRLLETDVCEAITVWEPRVTDVEVTALPDDSEPGRMLLQISYVVRSTNNLFNQVYPFYLEEGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN12</accession>
    <name>A0A398CN12_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_09965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03865">
        <property type="protein sequence ID" value="RIE03865"/>
        <property type="gene ID" value="D3H35_09965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901575">
        <property type="term" value="P:organic substance catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="2">
        <location>
            <begin position="49"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="3">
        <location>
            <begin position="383"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="4">
        <location>
            <begin position="717"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="820" mass="92541" checksum="936CF1123340FC77" modified="2018-12-05" version="1">MEQQSNWHGRWIWKAPSPRAGEGEHETVYFRRTFEVGSTGNCRLLARVSADSRYRLYLNGKSVVAGPCKGDRFTHYFESVDLSGHLVQGSNVLAAQVLHYAVSEPFRIGSGGSASVWRSGTGVFIFDGSIQYDNGNETINLHSDENWRYSEDRAIRFHPGELETLYVGGPERVDGSLLPFRWQTAGFDDSGWKKAVVVSEVMDEWFGQLTPWTLTPRPIPDLYEIHKGFVRVTRRIGGQSEPAFQTYSLEPLAEGYPVGAGEKLILELDAGELVTAFPFLEMEGGSGAEVKLLYSECYEAPAVSKASRNKGVRDDVDNGCLIGEQDIYLAAGIGGRDKTPPERYEPFSFRTFRYVRLEVNAGAEPLALRRFNFRETGYPIEAVADFASSDSTLTPLWNISIRTLKRCMHETYEDCPYYEQLQYILDTRLQALFTYPLSADDRLARKAIFDFHSSVLPNGMLQSRYPSVSPQVIPGYSVHWIFMISDHYRYFADLALVRRYLPTIDAVLGWFERQLTSEGLVGRVPAEYWAFVDWVDEWRDNRGVPDAHRQGPITVYSLLYAAALEAAAELNDEAVRTATADEYRRRARLIKQATIRYCWSDKERLFQDGPGIESYSQHAQVWAVLSGTLQGEEAEALMDGMLARPEMPRVSYAMSFFLFRALAMTGRYGKSFRLWDVWRKLADLNLTTWVEDPVSQRSDCHAWGAVPIYEFAAEILGVKPDGCGFDKVLVEPQTGELSWAKGSVATPKGLVRVEWELKLDRLFRLYVEAPAGMSIACKLPDGQRIECQGAGPHEIGAALRQARNRSERNSAEEREDGIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN37</accession>
    <name>A0A398CN37_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04766">
        <property type="protein sequence ID" value="RIE04766"/>
        <property type="gene ID" value="D3H35_04620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="139" mass="16065" checksum="2FC655085888CE57" modified="2018-12-05" version="1">MAGDEIRRNMALFPIGIVMKLTDLTARQIRYYEQHELIQPARTSGNQRLFSFNDVERLLEIKSLIEKGVNIAGIKQVMNPVGENEDDSTIINEQSEVKRRELTDSQLHRMLKQQLMTGNKRPGQVSLIQGELSRFFKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNF7</accession>
    <name>A0A398CNF7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferritin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04896">
        <property type="protein sequence ID" value="RIE04896"/>
        <property type="gene ID" value="D3H35_04375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="29"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="157" mass="18332" checksum="DAE4D0A85BA54072" modified="2018-12-05" version="1">MYYVWYAPLYRNSIVSADSACLQTAIQLIAEAVGGEREDELFYQYLISIAPAKDEKEIIASIQADEKKHNRMFRSIYRELTGQEAVPKNEEPFVQPANYADGIRKALFGELRAVEKYRKIRECLPREGPYRDMLFEIITDELKHADKYNFLFTLNHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNK8</accession>
    <name>A0A398CNK8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_28180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000054">
        <property type="protein sequence ID" value="RIE00494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00494">
        <property type="protein sequence ID" value="RIE00494"/>
        <property type="gene ID" value="D3H35_28180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="134" mass="15192" checksum="89DF00857EDB36CF" modified="2018-12-05" version="1">MFQTLYFAPVVLSTVALVQIFQNVFSVNPVGMLNYFLSWFQPSMLDSEWLSDPHRSLLIVAIAEGYKFAAVYMVIFYSALISISEEVIEAARMDGASGWKLYRYIKLPMIKGIIFTSIILVLNGSLKSFDIRTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNL1</accession>
    <name>A0A398CNL1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_08070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03912">
        <property type="protein sequence ID" value="RIE03912"/>
        <property type="gene ID" value="D3H35_08070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004761">
        <property type="entry name" value="Spore_GerAB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03845">
        <property type="entry name" value="Spore_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="340" mass="38494" checksum="5B98B2BC5B12628E" modified="2018-12-05" version="1">MLRYLYYHVLYVGMINIMLFVPHVLIEYRFKGAVSGMALAMVVGSIVAIGTSVCFRRFPGLGMYEIFDCFLPGWLTKILSSYSALTWALGGLLVVYIQAELIRTFFNPDMNEYWNLLIMVIAALWASTRSIRTVQFAQEILILMCAPLIFMILFKAIGNEWLNWDAIRLAAGYVRTKPSFVSFCAATFLFSGYLNLIVFNRMATAKTSNRYLWIIPIFGVFFMLVTFFVPIGFHGTAGIDKYVFLWSTTADSMEMQYGFINRVLYLFLVLYTNLSLIFVMNAWHVTIDILHSVFTGKVMPVDPSSTPADIGISLLRWASPRLFTPASLTMSGTSESRSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNN2</accession>
    <name>A0A398CNN2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_03295</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04976">
        <property type="protein sequence ID" value="RIE04976"/>
        <property type="gene ID" value="D3H35_03295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="52"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="365"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="398"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="611" mass="67960" checksum="8C8DEAF5F4E92C17" modified="2018-12-05" version="1">MFHKETIALPFRIFTKGEFMNHTKSALDPIRPALVLGKLLVWARSYWTSYSLLLVIIIASAALPTGVAEGMRRLFNAVQFGSISGMLSAAAMLAAVFFIGMVLALLRAWSMQKLSIRSTLDLQREVLGRLIRLPLRTFGNWHTGDKINRLNGSAVAAQEGLNQRIPQLLEQVLSIIILLVYLSVLSWGLVAGALASSLLFPLLSNLMGKSIRKWQMTMNESQAIQDSRLQDQMQGADVVRSFGLRESFNARWREQVEVTRRSGIRVYMWLTASGLTIFAGSWIGQIYIFSVGAWFVMKGNMEIGVIAAFMIAYDRLFYPFAHLANMWAAIQDSLAHGARVFQMVDPTDAKPMTEGDAPLPDYGDLEVDNVSFGYEEGKPVLQNVSVVFKQGTTTALVGPSGGGKSTLLKLVLGLYEPEAGDIRIGSVAIDRQTLGTWRKKTAYVPQDTTLFDASVFDNIRVGRLNATPEEIRRAAELAQADEFIQALPDRYETRLGERGLRLSGGERQRIALARAYVRNPEFLLLDEPTSALDGQNEHLLQEALGKLMVDRTVVVVAHRLSTIQNADCIVVMEEGCITEYGTHEELMAKAGRYAAMVRRGEWEHQVERVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNN3</accession>
    <name>A0A398CNN3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="9">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="9">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glyS</name>
        <name evidence="11" type="ORF">D3H35_06230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="9"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04213">
        <property type="protein sequence ID" value="RIE04213"/>
        <property type="gene ID" value="D3H35_06230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00255">
        <property type="entry name" value="Gly_tRNA_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015944">
        <property type="entry name" value="Gly-tRNA-synth_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006194">
        <property type="entry name" value="Gly-tRNA-synth_heterodimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30075">
        <property type="entry name" value="PTHR30075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02092">
        <property type="entry name" value="tRNA_synt_2f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01045">
        <property type="entry name" value="TRNASYNTHGB"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00211">
        <property type="entry name" value="glyS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50861">
        <property type="entry name" value="AA_TRNA_LIGASE_II_GLYAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR_1" evidence="10">
        <location>
            <begin position="588"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE04213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="693" mass="76239" checksum="DB1C9C7BC29A3528" modified="2018-12-05" version="1">MAKDLLLEIGLEEVPARFVRAAMDQLKDKTVKWLNDSRLSFEEVRAYSTPRRLAVIVIGLADKQADVNEEVKGPALKIAKDAEGAWSKAALGFGRSQGVDAESFVVREVANVEYIFANKSSVGVETSSLLPEALPALVTSLTFPKNMRWGAYDLRYVRPIRWLAALHGSEVVPFEITGVKSGNVSRGHRFLGADATIDNPAVYVEALKEQHVIVDVAEREKAIQEGIGRLAAERGWHIAVKEDLLEEVLFLVETPTVLTGSFDPAFLNIPQEVLITSMREHQRYFPVLDSEGRLQPHFVTVRNGDGLSIDVVAKGNEKVLRARLSDAKFFYEEDKKLVIADALAKLENIVYHEELGTVADKVRRTRAIADKLAQALRADDSVRADVSRTADICKFDLVSQMVYEFPELQGIMGEDYARKAGERESVARAVNEHYSPRNASDNPPASLVGAIVGIADKIDTIAGCFSIGIVPTGSQDPYALRRQAAGIVSTILAHGLELPLSELFSIALEIHAERGLKREAYDIRKDAQEFFTLRVKNVLTERNVRYDVADAILGAGSDDVRRTILRAATLNEAASEERRDEFRPIVEAFNRACNLGAKADSRQVDANLFADAAEGSLYEAWQTAHGTFVKAIAEADTDAAFAALAALKEPVTTFFETVMVMAEDEAVRRNRLALLALIADDVKAFADFTKLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNU1</accession>
    <name>A0A398CNU1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_16960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. EmrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02398">
        <property type="protein sequence ID" value="RIE02398"/>
        <property type="gene ID" value="D3H35_16960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="530"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="12"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE02398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="567" mass="61500" checksum="3EBECBF9F4656D86" modified="2018-12-05" version="1">MNNLSRGRIILTFIGIILGYFIALLDTTIVNIALPKTAEYFNRDVGDISWIMNGYNIAFAVLMLTASRIADQFGRKKLFLIGLIMFTLTSFLCGIASTLDLLILFRVLQGLSAAIIVPVTIPLAIQLFPKEKHGTVLGIWGAIAGVASASGPALGGILTEYFNWQSVYFVNLPIAIISFIVSYILIKESYDKTASKNMDIAGMLTISAAIFCFTLGLIETSDYGWSSFYVLSLFAGSLLSLTLFIVVERRSKNPMLPLSLMRISTFSASSAALLFTSIGIAAGSFLIAFYLMSLRNMSVLEAGMTIIASSLTATVFSVISGPVSEKIGGRFLASIGLTIITVTVYLFGSLDADSSRFDVVWRLSLLGAGLGISVVPLFGSAVNNIPADKLGVVSGVTNVARTLGMVIGVAILATILSSNMKNELSTAREKAIQTVQASALDASMKDGMITSIQSMNNESLQEGNAQQKMTLENVLEQVDQREKEALLQAPSQKQETIKVAFDHNREQIKQLWPIINAEIRSYMAKGFSSTFHLVSFLLIPGIFIAFFSDKRRQKVKGETKRTAVISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNV0</accession>
    <name>A0A398CNV0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_20245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02939">
        <property type="protein sequence ID" value="RIE02939"/>
        <property type="gene ID" value="D3H35_20245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="273" mass="29495" checksum="AF34D7227C54D44A" modified="2018-12-05" version="1">MRRRRVCRASRLLSKFGRFLRDRLYILSISRLKERFDMKHINKKVMLAAAGLILLLGYISISSADPSETSDAEGIYTNAEQAVFYVRALRSDGTIKDTGTGFMIRPDGVALTAYHVVKEADQVACVMNDASVMACPVIAYDVASDTAVLKISPEPAAASEKQRSFPYLPLRASAVKHGEKVFAIGYPMKDTKIVTEGVVNAPRAAVNGRDRILMSADLASGMSGGPLLDRYGKAAGILSGSLRTMNGIHLAVDAEAVNRVLKQANLSASGKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNW9</accession>
    <name>A0A398CNW9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein prkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04052">
        <property type="protein sequence ID" value="RIE04052"/>
        <property type="gene ID" value="D3H35_08865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013153">
        <property type="entry name" value="Prk_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010650">
        <property type="entry name" value="PrkA_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016230">
        <property type="entry name" value="Ser_kinase_PrkA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08298">
        <property type="entry name" value="AAA_PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06798">
        <property type="entry name" value="PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000549">
        <property type="entry name" value="Ser_prot_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00763">
        <property type="entry name" value="AAA_PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_PrkA" evidence="1">
        <location>
            <begin position="21"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="631" mass="72990" checksum="0506F69EA751DBB1" modified="2018-12-05" version="1">MDLFDRIADYRAESEKLNWTGTLRDYIELLRLNPKPAMTAHARVYDMIESHGVEERGAHKRYKFFESDIYGLDRTMEKLVEEYFHSAARRLDVRKRILLLMGPVSGGKSTIVTLLKKGLEQYSRTERGAVYAIKGCPMHEDPLHLIPSELRTDAERELKVRIEGNLCPHCEMRLRTEFEGDIMRLPVERVLISEANRVGIGTFSPSDPKSQDIADLTGSIDFSTITEYGSESDPRAYRFDGELNKANRGLMEFQEMLKCDEKFLWNLLSLTQEGNFKAGRFALISADELIIAHTNETEYKAFISNKKNEALQSRMIVMPVPYNLKVTDEEKIYQKLISQSDMNHIHISPHALRAAAIFSILTRLKESKKQGMDLVKKMRIYDGEEVEGYKEADLKEMQNEFPEEGMSGIDPRYVINRISSALIKHDMPCINALDVLRALKEGLDQHPSITKEEREKYLNYISVARKEYDNLAKKEVQKAFVYSFEESARTLFENYLDNIEAYCNWAKMKDPLTGEEMDPDERLMRSIEEQIGVSENAKKAFREEILIRISAYSRKSKKFDYSTHERLREAIEKKLFADLKDIVKITTSTKTPDENQLKRMNEVTKRLIDEHGYCPVCANELLKYVGSLLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNX8</accession>
    <name>A0A398CNX8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Malonyl-[acyl-carrier protein] O-methyltransferase</fullName>
            <shortName evidence="2">Malonyl-ACP O-methyltransferase</shortName>
            <ecNumber evidence="2">2.1.1.197</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Biotin synthesis protein BioC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">bioC</name>
        <name evidence="4" type="ORF">D3H35_20520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>malonyl-[ACP] + S-adenosyl-L-methionine = malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:17105"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9954"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78845"/>
            <dbReference type="EC" id="2.1.1.197"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; biotin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.197" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02989">
        <property type="protein sequence ID" value="RIE02989"/>
        <property type="gene ID" value="D3H35_20520"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010340">
        <property type="term" value="F:carboxyl-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102130">
        <property type="term" value="F:malonyl-CoA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00835">
        <property type="entry name" value="BioC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011814">
        <property type="entry name" value="BioC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02072">
        <property type="entry name" value="BioC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="3">
        <location>
            <begin position="51"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="276" mass="30508" checksum="3852ED32A100FE89" modified="2018-12-05" version="1">MTGKINGVGVRFDRSADSYDAHSDVQRTMADMLMASIAEPMNDGAADRLDILEIGCGTGALTHRLTDEWPAAHITALDLAPAMIERAKRRVSSNRACFIHADAEAWVNVAKAASFDLIVSNACFQWLASPGITMRRLRSLLRIDGSLIFATFGPATFCELHEAFAEAYRINGLEPQRHGLSFQSSNQWVDMLKDAGWSNIECQRRLHTETHASARDFLHAVKAMGASASEAVGSRGLGPRRLFADMYKEYEERFGTPGGVTATYELLLIRSELKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNY0</accession>
    <name>A0A398CNY0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01587">
        <property type="protein sequence ID" value="RIE01587"/>
        <property type="gene ID" value="D3H35_24895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025699">
        <property type="entry name" value="ABC2_memb-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13346">
        <property type="entry name" value="ABC2_membrane_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="218" mass="24745" checksum="1270ACD33FD86248" modified="2018-12-05" version="1">MYNLVMKDLKLGVNPFFFVLPLLTGALMLIPSWIYFLVPLYFCWLTVPNTFAGLKAQNDLLFTAMMPVTKRDMVKARVTVLVILELLHMAVAMIFGMLTIRLYPDMIYYFFAPHMGFWGLCFAMMAIFNLILLPMYYKTAYKYGKAAFASIAAAMLFAGMAQWLGIRSSYVADIFNGTGADNTALQASILIAGIVIFIVFTMIAYRMAFKRFLKVEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP05</accession>
    <name>A0A398CP05_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_20705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03019">
        <property type="protein sequence ID" value="RIE03019"/>
        <property type="gene ID" value="D3H35_20705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="186"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="293" mass="33014" checksum="220C1B0AB2F12EAD" modified="2018-12-05" version="1">MNPIRKQFRSDIAFPFDVAYKNTKSSLSELPDHLHDRFELVYVYSGKGTFFIDHTLYDMSEGDWFLLPGNTIHRALPNAANPVTSTAVFFSSLLIRQSSIGEPFGLLRCYEWARKSKTYKLRLSASDESMAAACLDALQEELTNRQPGYRHSALLQLELVLLRLSRALYTTADHSSEASIGPDWINTALQHIDENPDSDLGLTSLSRLTSVSAAHFSRVFKQWTGMNVTDYVNAKRMIRASELLLSTDQSVAEIASLCGFESLPHFHRLFKKLIGRTPAAYRRGNRMNATDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP40</accession>
    <name>A0A398CP40_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05146">
        <property type="protein sequence ID" value="RIE05146"/>
        <property type="gene ID" value="D3H35_01885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="345" mass="37810" checksum="602B8254D7F51022" modified="2018-12-05" version="1">MSEARSKEEPKWSEDRVRELFRNSADVIVQKCQIGDDSSTDIVLAYSDGLCDSSQIGLVVLPGLSKLVSEKGTLDDDSVWMAGKLPLVTFDETPTSGQLSESVFQGDLLIFILQSGTAYRLSIGNLPRRSPSESNTEISIKGPKDGFVEDIVVNVALIRKRIRSSDLCNESFTIGRRTKTRISLLYFHDIISPDVLKEVKRRLSQIDIDGIYGSGQIEEMIADSKYSMFPLFASTGRPDYTVNSLLAGRFVLIVDGSPLALIGPAELSLILKSPEDIHFNYAYVSFARVVRGQACSYPFSFPGFGRPLGISPGSKSHSGSWLQFPSRVWVCPCRANGNVSAAHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPB2</accession>
    <name>A0A398CPB2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00774">
        <property type="protein sequence ID" value="RIE00774"/>
        <property type="gene ID" value="D3H35_26645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="110" mass="12577" checksum="B68258BE23FB9042" modified="2018-12-05" version="1">MEFDESTVHALLDFDLLSKLVVGIGEVSDITGVPQRQIRYWEDKGIIRTIKDGEGTTRKYDYMNIKKILLVKELLDDGYTLDAAARKIEDRLKLVDEAFKKLADRKGSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPB5</accession>
    <name>A0A398CPB5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_13155</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. EmrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01747">
        <property type="protein sequence ID" value="RIE01747"/>
        <property type="gene ID" value="D3H35_13155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="17"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE01747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="499" mass="53873" checksum="E32874659B1FF3E8" modified="2018-12-05" version="1">MSKSSAFDSSSIKKGPLLFVMILGAFIAVLNQTIMSVALPELMVDFDIAASTAQWLTTGYMLVNGVLIPITAFLMQRFTTRELFQTSMIIFLVGTIVSAVASNFDILLVGRLIQAAGAGIIMPLLMTVILTVFPPEKRGAAMGMVGFAIIFAPAIGPTIAGYVMEHFSWRTMFYGMIPLALIVIGVAFFYLKNVSERKYPKIDIWSIILSTIGFGAVLYGFSSAGSKGWSSAEVILSIVAGVVSLILFTWRQLVSKSPLLDLRAFKYSMFSLTTVINIAVTMVMYADMMLLPLYLQNARGYTALESGLLMLPGALLMGIMMPVTGRLFDRFGAKWLSIIGMAITIVTTIGFVNLTDSTSYTYLVLMSTGRRFGMAMFLMPITTAGLNQLPSRLNEHGTAISNTIKQVAGAIGTSLLVTVMTSSTKTHLTDMMAAGGSGELSKEQMMMEASIQGINDSYLVIIGIGIVGLVLSFFIKRAGQAKEAEEPGIALKRTTVSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPM0</accession>
    <name>A0A398CPM0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 4">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">galU</name>
        <name evidence="6" type="ORF">D3H35_00765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 4"/>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05356">
        <property type="protein sequence ID" value="RIE05356"/>
        <property type="gene ID" value="D3H35_00765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01099">
        <property type="entry name" value="galU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="5">
        <location>
            <begin position="6"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE05356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="299" mass="33736" checksum="60932EBECBA43329" modified="2018-12-05" version="1">MKKVRKAIIPAAGLGTRFLPATKAMPKEMLPIVDKPTIQYIVEEAIESGIEDIIVVTGKGKRAIEDHFDIAFELEHTLEEKGKFDILRKVQQSSNVEIHYIRQKEAKGLGHAVWCARSFIGNEPFAVLLGDDIVQSDTPCTRQLIEQYEQTGKSVIGVQAVGTDQTNRYGILDPIEKRGRLYKVNRFVEKPPQGQAPSNLAIMGRYVLTPEIFEYLGRHEIGAGGEIQLTDAIQKLNEDLGVYAYDFEGMRYDVGEKLGYIMTTVDFALRNDELKFRLMDQLEQLLWREKVSGRHGPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPP9</accession>
    <name>A0A398CPP9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_05910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CvfB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04160">
        <property type="protein sequence ID" value="RIE04160"/>
        <property type="gene ID" value="D3H35_05910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014464">
        <property type="entry name" value="CvfB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039566">
        <property type="entry name" value="CvfB_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040764">
        <property type="entry name" value="CvfB_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37296">
        <property type="entry name" value="PTHR37296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17783">
        <property type="entry name" value="CvfB_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13509">
        <property type="entry name" value="S1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012524">
        <property type="entry name" value="YitL_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="159"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR012524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="302" mass="34018" checksum="08FE93AFEE291F89" modified="2018-12-05" version="1">MSLLAGTVTRVFVRRELPPYGWFVGEDESEGPDVLLPYGEAVVKRPEPGDDIDVFLFHDDKGRMTATQRTPLIRFGEMARLQVADFNPKFGYFLEMGIGRQLLLPVKEMPPERRKVWPQNGDELHVVMKRDKEGRMLARLAKIDDFEPVVFRAPSTWKGEWQEAYVTDVFRDGAFALVEGGILGYGALGYIHDGVMSHPLRIGEKFRSRVIQVRDDGRVTLGMRPPKEEGRLEDADRILAFLKERPGGGMPYSDATEADIITKRFGISKSAFKRALGKLMKDGLVVQKGAWTYLSGEGQGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ50</accession>
    <name>A0A398CQ50_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Efflux RND transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04340">
        <property type="protein sequence ID" value="RIE04340"/>
        <property type="gene ID" value="D3H35_06995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="827"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="856"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="882"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="930"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="959"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1005" mass="107524" checksum="506C0D5927A6A64A" modified="2018-12-05" version="1">MQSFIQGTFRNKAAVIILIVMVLGLGVFSYFKLPMEFLPEADNPQVTVSVIGPGYDAATMEQSVTNPLEQAVAVIKGKTNTFSTSGDGFSQLNLNFDSSTNMKEAKAEVEKAVGAVQLPERVSPPYVVQFNTSMIPISFITLSFNNENLDQAQREKIEQRVSDAFKGIDGVGSAQLFGKSQPKVVITPDTAKLAAKGVPVQALYGVLQGRETSSSVGQTNIDGQVVNLSVTAGLNDVKTLAGLPVAAGVTLGDVAKVEFDTNAKETINRVDGKEALTVVISKDASSNAVSVGKDIKKTVEDLNKENKDATLKITLSTSDQVVHSVNSMLREVLMGALFATIVILLFMRNVRATLVTIVSIPLSLGMTLFLLDMSGVTLNILTLGGVAVAVGRLVDDSIVVIENIFRRLQKESFSVSLIVDATREVARAITASTLTTVAVFLPMSLLRGGLQAFLLPFALTVTYALLSSLIVALTVIPLLSSGVLKNSKIKEHLPSKRFTSFLEWNLRFKWLPILIAFLLLLGSVGTYFSLPKGAIDNSSASSLSITLDYKPDTPVDEVRENGLKLEKFLMEQEGQDYVDMQMGNSADGATYGNVNSPTLVSYTVQMKDGADADKIIDAVKGQRANYPGADLNAGPGSFFGGGSSTQVFVDVTGDNLDQLTKSADEVIAKIKPIKDVLKVESNQEEKKTVYTLKVNASQAKAGDIASQLQGMLNSVPIGTMKANGQPVSVILEPVLKPQSEADLENLTVMTDAGPKPASSVAEWVKEELPTKFFHKDGKSYVRVAATVEPSQLSIVGADIKKAMNDVKTPDGVKLNVGGASADQSEDFMSLFMMMLVSIGIVYLIMVITFKTLKAPLAILSSLLFVPIGAVLGLLIGNVKPDFTAIFGVVMLVGIVVTNAIVLIDRVRQNEETMTIREALLEAAGTRMRPILMTAIATVCAMLPLVFGTSESGSIVSQSLAIVVIGGLIVATLLTLVIVPCIYELLFFRKSKRQRVAKAKQQTIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQA5</accession>
    <name>A0A398CQA5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HU family DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_03890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04642">
        <property type="protein sequence ID" value="RIE04642"/>
        <property type="gene ID" value="D3H35_03890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="90" mass="9752" checksum="38DCCF05645B1420" modified="2018-12-05" version="1">MNKTELIAKVAELTDLSKKDATQAVDAVFDVISEALQSGDKVQLVGFGNFEVRERSARKGRNPQTGVEIEIPAGKIPAFKPGKQLKEGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQD6</accession>
    <name>A0A398CQD6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04755">
        <property type="protein sequence ID" value="RIE04755"/>
        <property type="gene ID" value="D3H35_04550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="212" mass="23292" checksum="AE55842010C0BF32" modified="2018-12-05" version="1">MGSDRGEVWLWFVDGERPDWIEGTGLPILSERGVAGPNDCVLHVGRPPKRHKAVTGAGAARGSGLSAWRMNAATRAILALRPEEIERRLRREGLAARISEPKRGGGFGNGKGAMLPFAASRRYAATVFGLDAVEIRRAHVFGPTYDRELGDRVRWLLAKAAARALYVLGLDFGQVELELTDQGRVVIVSVSPDMRPSPGGESNFWRKRFVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQG4</accession>
    <name>A0A398CQG4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_04355</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04722">
        <property type="protein sequence ID" value="RIE04722"/>
        <property type="gene ID" value="D3H35_04355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="135"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="135"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="246" mass="27685" checksum="5E9A0C17B5EFD214" modified="2018-12-05" version="1">MGESGSVLVVDDEREITELITLYLEKSGFVVHTASNGEEALLLADSLRPDLIILDILLGKPDGIEVCRSLRASACADVPILFLSCKSEDCDIIRGLSEGGDDYITKPFSPSQLVARVQAHIRRRRQRERLADEPSDSLSFEGLDIDFRNHEVRMNGELVTLSVKEFELLVVLGRQPNRVFSLEELYRKVWNTDSMGDTRTLMVHISNLRKKIEADPSNPVWIQTVRGFGYRFCPGLLSQPDDKLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQG7</accession>
    <name>A0A398CQG7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_20830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03038">
        <property type="protein sequence ID" value="RIE03038"/>
        <property type="gene ID" value="D3H35_20830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="170" mass="17559" checksum="DE8648860F1965B4" modified="2018-12-05" version="1">MAWDVAAYAIALAAIVIAAAVAIGAAAAHRSLRRLEKTAQRLEINAAEALAECREFAFEARTAAASCKAGLQGFQTLAEGARALGTAAGNAAHTATRLTAAWHDRLRPNEAAASKQADSSGAESGSDWLELRGFVQRFLRGRISGLHAESSGSNQAPRSSAANADATQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQP5</accession>
    <name>A0A398CQP5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_05205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04863">
        <property type="protein sequence ID" value="RIE04863"/>
        <property type="gene ID" value="D3H35_05205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="72"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="279" mass="30528" checksum="981F283D4C5683A7" modified="2018-12-05" version="1">MRETLSFRTFKYASLAILMLFTLFPFLWLVDTTFKSTEEMFASIPTWLISNFTFEHYVWATGEQGMNIGKLLSNSIIVCALTALCTGLIACVSGYGLARFKVPGIGLVIVLFVLAQMIQGPLIMIPWYKLASAFSILNTKTVLVLIYNTMTIPVAVWIMSGFFKSVPKELEEAAYMDGSGKLKTLFKIMVPMALPGLVSVSLYSFILGWNDYQYSLILTNSLAAKTVQVGIAEVMESMGAANWGGILASGVIVILPIILIFSLIQKLLIEGLTAGGIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQU1</accession>
    <name>A0A398CQU1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_10080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03639">
        <property type="protein sequence ID" value="RIE03639"/>
        <property type="gene ID" value="D3H35_10080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033425">
        <property type="entry name" value="MASE3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17159">
        <property type="entry name" value="MASE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="301"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="442"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="697" mass="78689" checksum="1690E9938CBA081C" modified="2018-12-05" version="1">MLMNRAEMKTGWIILAASLLFAILQWNGAWLDQWVAALDQTTFQLAMEIVGFAICVAVLAFGWMIFVPTLCRQRLMIAALFAAIGVFDLLHGLSAYGMPLYREAAGESPMIALGWISQLFGSAGLLAIFSLRNKPVSPRSRLYALAALVAVVSLVSLAVFRANNWNTAWIDALRPFVQGAVVTLYAATIAIILYRHRRERPQAMLTIVQALVWLLFSKLEMAAGANDAHMLLSEAFKLAGYYHLLKGIYYVLIEEPFKRQKKAEARIHFLAYHDELTGLPNRRLFKERVQSEMDRARLGHHRFALLWLDLDRFKTINDSMGHAFGDKLLAEVALRLEKFSDRRENVFRMGGDEFTILLPGVPDERAAESAADRLVSLLDTPIKLGQSAFHLTGSVGMALYPDDGSSLDLLLQNADTAMYRAKEGRNGWTRYTPDMNLRAKERLLLENDLRIALELDQFRLVYQPLVDLESGKLVGAEALVRWHHPQRGEISPAEFIPICEENGFILPLGEWVLQQACRQMKEWELAGYPPIIMSVNLSIRQFRQHDLCDRIRKTLQEADVKPEWLELEITESIMADVAFAVDMLANLKNIGVRISIDDFGTGYSSLHYLKRFPIDKLKIDRSFVSDVLSDRNDAAIVSGISAMARNLNLRVTAEGVESEGQVEFLKLQRCQEAQGYYFSKPVAPDMFVRLFAKEAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRC0</accession>
    <name>A0A398CRC0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proA</name>
        <name evidence="9" type="ORF">D3H35_04230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04700">
        <property type="protein sequence ID" value="RIE04700"/>
        <property type="gene ID" value="D3H35_04230"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="9"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="415" mass="44337" checksum="9451B514CE5A2E6D" modified="2018-12-05" version="1">MSEVVTKATLAKEAAAVLNRLTTEQKNEALLHMADALITEQASLIAANEEDLERGRANGTSPSMLDRLRLTPDRIAAIADGVRQVVELPDPVGDVLEAFERPNGLRIVKSRVPLGVIGMIYEARPNVTVDAAALCLKTGNAVVLRGGSAALSSNRRIAEVLRGAMSATAMPPESLQMIEDASRSSVDEMLKLNGLLDVIIPRGGASLIQNVVQNATVPVIETGAGICHTYVENSADYGMAEAIAVNAKVQRPSVCNSMETLLLESGFAAGHLPALAAKFRELNVELRGCEITAKLAPEIKPATDENYATEYNDYILNIKVVDGLDEALAHIRRFGTMHSECIVTESQANADRFLQEVDAAAVYHNASTRFTDGFEFGFGAEIGISTQKLHARGPMGLPALTSTKYKVVGTGQTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRM0</accession>
    <name>A0A398CRM0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_02140</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05192">
        <property type="protein sequence ID" value="RIE05192"/>
        <property type="gene ID" value="D3H35_02140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="197"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="264"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE05192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="469" mass="53016" checksum="907251100D9AD013" modified="2018-12-05" version="1">MKRLLRAFKLRQSLLSQYLLIVLAALLLLPLSSPLVSLLLYWPLRASVDPAEALYRDGEKLEKMWRSEAAKLEGAADGQVDETLRKLKIEYPRADMFWVDESGKTRLTLTASKDIPAIWNASYTVRFMKERTGGDPFTVIGFIGEGERRGFMVFELARSTMNSGRGWSGANMELRWIFAGFLLILLLFLLVSLLFFYRIRRRLVRLQKAMTVPSDTGIPGPVNALNEDEIGRLERSFNRMVQKLEDSREREIEEEALRRDLIAKLSHDLRTPLTTIRGHAFSLKQEALTDKGKSSIELIERKTDYLGQLIENLISYSLLTSGKYPYRQQRVDIVRLARTHFAGWYPVFEQNGFEIDSELSENAFYWEADPQWLERVLDNILQNVLRHAKSGRFVALHVSACNGGSIAIRDRGPGMTGDSEEKGMGIGLSIATLMLKEMNLSAHVTTGVSGTIFIVASNAAPSDSFLTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS51</accession>
    <name>A0A398CS51_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Galactokinase</fullName>
            <ecNumber evidence="11">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">galK</name>
        <name evidence="15" type="ORF">D3H35_18270</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="11">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="11"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02627">
        <property type="protein sequence ID" value="RIE02627"/>
        <property type="gene ID" value="D3H35_18270"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00246">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022963">
        <property type="entry name" value="Galactokinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="6 11 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="14">
        <location>
            <begin position="10"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="12">
        <location>
            <begin position="118"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="13">
        <location>
            <begin position="288"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="36"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="125"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE02627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="393" mass="43626" checksum="CC491EB3E0ED2A82" modified="2018-12-05" version="1">MVRVSELKKLFIEKFGDDDRQIRVFLAPGRVNLIGEHTDYNGGSVFPAALTFGTTLLIRPRDDGKLLFASTNFSITREISLDKIAFEEADDWTNYPKGIVWELALREIQLSSGYEFLYHGEIPNGAGLSSSASIEVVTAFALLTLEGKRTDTVEIAQWSQHAENEFVGVKCGIMDQFAVANGRKDHAILLDCDTLKHELVPFRSGDYKLVIGNTNKRRGLVDSKYNERRAQCEQAVRELRAEFPGLTLLGQLTLEQFNANAHLISDETVRLRARHVVEEIDRVSRSMEVLLRNDLAAFGLLMNASHDSLRDQYEVTGAELDAMVDAARAVPGVLGSRMTGAGFGGCTVSLVHQASVERFQTEVGQKYEAATGLHPDFYVCDIGDGVHEIKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSK5</accession>
    <name>A0A398CSK5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Quinol oxidase subunit 2</fullName>
            <ecNumber evidence="11">1.10.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">cyoA</name>
        <name evidence="16" type="ORF">D3H35_14260</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes quinol oxidation with the concomitant reduction of oxygen to water. Subunit II transfers the electrons from a quinol to the binuclear center of the catalytic subunit I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 a quinol + O2 = 2 a quinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:55376"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.-" evidence="11"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01934">
        <property type="protein sequence ID" value="RIE01934"/>
        <property type="gene ID" value="D3H35_14260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009486">
        <property type="term" value="F:cytochrome bo3 ubiquinol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016682">
        <property type="term" value="F:oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04212">
        <property type="entry name" value="CuRO_UO_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010514">
        <property type="entry name" value="COX_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034227">
        <property type="entry name" value="CuRO_UO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011759">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006333">
        <property type="entry name" value="Cyt_o_ubiquinol_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06481">
        <property type="entry name" value="COX_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000292">
        <property type="entry name" value="Ubi_od_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="SSF81464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01433">
        <property type="entry name" value="CyoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50999">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_TM" evidence="15">
        <location>
            <begin position="24"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="14">
        <location>
            <begin position="128"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="283"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RIE01934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="331" mass="36335" checksum="C00DD5661E89226E" modified="2018-12-05" version="1">MKTTGWIKRTAAFAALAVMTVVMTGCGADWGVLDPKGQVGKQQLDLIIISTLLCLVVVVPVLVLTAVIVWRYRMRADSKAKYDPNWSHSTKLEAIWWGVPIVIILALAIVTAIYTYKLEPSKPLEHEAKPITIQVVSLDWKWLFLYPEQGIATVGYVQFPEDVPVHFQLTSDAPMNSFWIPRLGGQIYTMSGMAMSLNLIADEPGEYMGSGANFSGKDFAKMQFTAKASSQQEFDDWVKGIKSSSSEMTKVGYDELAKPGVTEEGVSYSAFPQGLFDQIVNKYGEGHEHGGSAENKAEGHEGHEAQPAATAENSADSQAAESQTNHHEHHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSQ1</accession>
    <name>A0A398CSQ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02837">
        <property type="protein sequence ID" value="RIE02837"/>
        <property type="gene ID" value="D3H35_19600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017370158" evidence="1">
        <location>
            <begin position="28"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="277" mass="29766" checksum="DEEBB9279CA5C51C" modified="2018-12-05" version="1">MSPLRKGAALACLVLLAVQLQGCGARALSEPAFGPSAEPAAASKTPSAVKPAPLTAEPQVKRVSMSPPIPMQLVNLPLFGDRDGERIDKLLNWVAEADRHKIDGVGLSSPLHGRSWAVDLEYEDGATLQIRPAWQCESTQDEQGDTTSNCQAVAGKVWIAGSDREAYFADSAPLFRFVTETFQEWMPGVKPVEYPELIRPGQPFAIKGHGSLASEAHVVLSKDNKPLWTSESVAVMDGEFEINGMLPENSVPEGAYQLDVKSDKTSYGFTVNVSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSY7</accession>
    <name>A0A398CSY7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_07190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04369">
        <property type="protein sequence ID" value="RIE04369"/>
        <property type="gene ID" value="D3H35_07190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="300" mass="33541" checksum="24706FB3791F9ED3" modified="2018-12-05" version="1">MSYVVEAKRLTKSFGKVKAVNEVSFALEEGKIYGLLGRNGAGKTTIMHMIAAQQFLTSGEISVFGERPYENDRVLERVCFIKESQKYPDHYRVDDVLKFAESRFKGWDREFASRLLDDFRLPLDRKMKKLSRGMLSSVGIIVGLASRAPLTIFDEPYIGLDAVARSLFYDRLLEDYAEFPRTIVLSTHLIDEVSRLLEHILLIDGGRLLLDEDAERLRGQAYKVVGPAAKVAEFSIGKEKIGSENMGGIASATFYSGLETKERRRAEALGLEITPVTLQQLIVHLTSGGSKTPMNEEAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT79</accession>
    <name>A0A398CT79_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_20825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03037">
        <property type="protein sequence ID" value="RIE03037"/>
        <property type="gene ID" value="D3H35_20825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="216" mass="24957" checksum="75DA18E2C7EF2E44" modified="2018-12-05" version="1">MLPQEETSTRNQILQLLKMQGNRRINELSKALGITEMAVRRHIQMLERDGLVASLLVRQPMGRPMYRYSLTEQADELFPKNYSQLTLDLLSELEDQDGGAGVIDRMFEGRRDKLEARYKDRMQHKPLEERVAELSSIQNGGGYMSEWELDERTGEFRLYEYNCPVAQVANRYRQACKCEKQLFERLLDADVERTECLADGGARCTYAIRPAQAGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTD5</accession>
    <name>A0A398CTD5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02571">
        <property type="protein sequence ID" value="RIE02571"/>
        <property type="gene ID" value="D3H35_17965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017472207" evidence="1">
        <location>
            <begin position="35"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="161" mass="17698" checksum="0D2C336E110375D8" modified="2018-12-05" version="1">MFKKLALSLVAVGLLSAAPLAAGIPAWQADVTHAATYAYGYTKIIGYYDTIPNDFLATYASPFRDYKEITYVGGAKWPATKSHVTDTRIPDGWVITEKGSPYNPYAYAPPSYSTLVCINGAPKGTVLWVHPTSRIPSGWAITEISDHIFPEKRSMRIVRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTM6</accession>
    <name>A0A398CTM6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside-diphosphate sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03207">
        <property type="protein sequence ID" value="RIE03207"/>
        <property type="gene ID" value="D3H35_19760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="95" mass="10342" checksum="20CC9FF3AE34D07C" modified="2018-12-05" version="1">MEELMTEIVVHLSQSHQQMARILDAKRQVTVRLSHIVQGLPDVQPQLNGLTGLLGSSSQVNKSIVAYLNSLADFQDAVADSLTNVVKAITVSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTQ8</accession>
    <name>A0A398CTQ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tripartite tricarboxylate transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_12795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0065 (bug) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000038">
        <property type="protein sequence ID" value="RIE03247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03247">
        <property type="protein sequence ID" value="RIE03247"/>
        <property type="gene ID" value="D3H35_12795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005064">
        <property type="entry name" value="BUG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042100">
        <property type="entry name" value="Bug_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42928">
        <property type="entry name" value="PTHR42928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03401">
        <property type="entry name" value="TctC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017082">
        <property type="entry name" value="YflP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="300" mass="32260" checksum="0918BBEDBCC22328" modified="2018-12-05" version="1">MLREKEGSGIPEQDDSHFHPFSAGGAADLSVRALQPKLEKELGQSVEVIDKPGGSGALAMNEVIKSAADGYTLGFTGVGPAVITPLSNDVGYTPEDFATVGAHMLIPYVLVVPYDSKYENLSQFLDEVKANPNKIRIGTPGPASTSYLALQQLAEKQGLQFQIVPFNGGVDTINALLGSNVEAIVNVDSELPAYLNDKKFKTLTVLSDKRSTVVPDTPTSAEQGIDFTINSVPPNGLYAPKGTPANVIAKLEKAIKAATEDEEVKKTFQNIHINPEFTSAADFRKAIDDSYAYYKEILKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTU0</accession>
    <name>A0A398CTU0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04689">
        <property type="protein sequence ID" value="RIE04689"/>
        <property type="gene ID" value="D3H35_04170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="393" mass="43037" checksum="23CD378CB6247A14" modified="2018-12-05" version="1">MEPTDHELKELLANGPLSRHGFNDELRKRIEREISHQERRPRARLFGSAYRYGAVGALAVAILVGFWQWGLPALNGGANNELSKTSSSISDITNAAVSNEPPRAALLIGTRTDRLSGDGESTVSSYRTVLVAPSAAGLEVVADGPGLYMPYKQNFWKIDAATDSADGEQQLHSSKLSAGVKPVAMVTEPVPGLSEKLLFAGNRYVSILQTVKSAEPDGKSQTFAWVKDFDQLNTPRENKPFDPATEPHVALGEWLGTKTTEEQWAIVRQEGQWKPEKPAAGKSATDKSKWQALGTPLPELIVSYDSLGLSWEQIKQFNPKAVDAFTSPSDDILATVEEEGIVIYPFRQADPQAKSLTVKLAEGESVVMVQWALDNYVPTWKQRLGEWIPPASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU43</accession>
    <name>A0A398CU43_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_11915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03377">
        <property type="protein sequence ID" value="RIE03377"/>
        <property type="gene ID" value="D3H35_11915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="246" mass="27288" checksum="607FEE8F6FB4E7C0" modified="2018-12-05" version="1">MNRSHFIITGTSRGIGEQLARLLLESDSFVYGISRGNSDTLDSYKKYSHYPFDLSNIMGIESLMNGIFAQIDTDNADMICLINNAAMLEPLNAIDQCEVEEINQNLQISLVAPMILTSCFIKRSDNDQIRRKIINISSGSGTYPAPAMSVYCSAKAGINMFSQCVGLEQSMREHPIEIIAVDPGMVDTELQSVARGKNEREFVMAKYFDQAYQSGLLQSTESLGKQLLTIIEKKFAPGKLVKYSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUE6</accession>
    <name>A0A398CUE6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Anthranilate synthase component 1</fullName>
            <ecNumber evidence="5 11">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">trpE</name>
        <name evidence="14" type="ORF">D3H35_03965</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="5 11"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04889">
        <property type="protein sequence ID" value="RIE04889"/>
        <property type="gene ID" value="D3H35_03965"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="13">
        <location>
            <begin position="28"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="12">
        <location>
            <begin position="230"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE04889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="521" mass="58424" checksum="6984D82A1FB10EA0" modified="2018-12-05" version="1">MDQRELQQVIAMAGRYNVIPVVRTLLADTETPIRVFQHLSRDKRAFLLESVEGGVKWARYSFIGTDPFLVLKLKKNEVSLEQGGKTETHTTNRPLELLREKLRGYRSPSLPELPPFTGGAIGFFGYDLLQYYEKKLPPHDVDDLQMDDMQFMFCDRIIVFDHFKQQVLVIGNVHVKDGAADADIEASYKEAVQGIEETIRRLQRPLPTFASASAPPMDPDLGEIGSNLTKEQFLSNVESAKEYIRAGDIFQVVLSQRFHIETEVDPLHVYRVLRTMNPSPYMYYLKLDDEVIVGTSPELLVKVDNGKVETRPIAGTRPRGRTPEEDAALEKELLADEKERAEHVMLVDLGRNDIGRVSEYGTVKCDSYMEIERYSHVMHIVSNVTGTLAPDKDFYDAFLSCLPAGTVSGAPKLRAMEIIAELENEARGAYAGAIGYLGFSGSLNTCITIRTIIFKHGKAYVQAGAGIVWDSVPENEYQETVNKAKGMLKAIRAAEAAFPQSSRKQAIYASLGDRRTNLDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUS0</accession>
    <name>A0A398CUS0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplO</name>
        <name evidence="10" type="ORF">D3H35_02335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05009">
        <property type="protein sequence ID" value="RIE05009"/>
        <property type="gene ID" value="D3H35_02335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="9">
        <location>
            <begin position="28"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE05009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="147" mass="15497" checksum="F56A7A565AF9F011" modified="2018-12-05" version="1">MKLHELSPAEGSKFSSKRVGRGAGSGLGKTSGRGHKGQNARSGGGVRPGFEGGQNPLYRRVPKRGFNNDRFATVFAIVNLNQLNGFSAGTEVTPELLLSEGILKNPKDGIKILGNGELNVQLTVKAHKFSQSAVEKIQAAGGKTEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUS9</accession>
    <name>A0A398CUS9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_20915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03051">
        <property type="protein sequence ID" value="RIE03051"/>
        <property type="gene ID" value="D3H35_20915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="266" mass="27483" checksum="09B6110EF92D519E" modified="2018-12-05" version="1">MSYVLGMDVGGTNVVAGLFDSHGTLVRKIKTPTEKRRGADGLLLQLAGFATELLDAEGVARERLGAIGLGLPGFIDPIAGLVDAANLPLSRTPVSDRLGELTGVPVTVQNDVKMIVYGESLRGAGQNLPHVLGVTLGTGMASAWVSQGRLHDGAGNLAGELGHITFPDIPYVCGCGMKGCIETVASATGIARQARDAIAEGWEGPLSARVSADRLGELTSKDVSEACRAGDSMAIEIYRRTANWLSQALVPVIAVLCPDVIVVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV37</accession>
    <name>A0A398CV37_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02894">
        <property type="protein sequence ID" value="RIE02894"/>
        <property type="gene ID" value="D3H35_19960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="142" mass="15178" checksum="AE11DD3ECB41EBCA" modified="2018-12-05" version="1">MLDIMLFLHIIGAVGMGIYALLPFLAGKFKKLSGSAQEGLASGLISAGRIGQYSLVLQLLTGGYLISNMAEYTVAWMITIVVLFLVIGALSGIVQKPLKNIVAFSSGGQDASSSISRVQTLSSIIFVAFIVIIWLMKNPWIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVR3</accession>
    <name>A0A398CVR3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycerol-3-phosphate acyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Acyl-PO4 G3P acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Acyl-phosphate--glycerol-3-phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">G3P acyltransferase</fullName>
            <shortName evidence="10">GPAT</shortName>
            <ecNumber evidence="10">2.3.1.275</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lysophosphatidic acid synthase</fullName>
            <shortName evidence="10">LPA synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">plsY</name>
        <name evidence="11" type="ORF">D3H35_03810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:34075"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="2.3.1.275"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably interacts with PlsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the PlsY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.275" evidence="10"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04628">
        <property type="protein sequence ID" value="RIE04628"/>
        <property type="gene ID" value="D3H35_03810"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01043">
        <property type="entry name" value="PlsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00023">
        <property type="entry name" value="TIGR00023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE04628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="205" mass="21405" checksum="196348E98D1237BC" modified="2018-12-05" version="1">MFNTIIAIAIGYLLGSVSFSILIARYLRKIDIRQHGSGNAGATNTLRVLGKGPAIGVFLLDIAKGVGAVLIGFALGDNSAWVAVAGGLASIAGHNWPVFFRFKGGKGIATTVGVMLMLSFLPTLLAGIAAIVIIVLTRYVSLGSMVFAVLLPILYAAFGESSAYIWAGVAVALLAVLRHRKNIVKLMNGTENKLGGNKKGEQHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVX9</accession>
    <name>A0A398CVX9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_04165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04688">
        <property type="protein sequence ID" value="RIE04688"/>
        <property type="gene ID" value="D3H35_04165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="26"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="130"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="186" mass="21833" checksum="6C76B23D11BF9896" modified="2018-12-05" version="1">MNPEVKLDYMKHMSESDDAGALLNELMTAYGKDVWNYAYSITRKWDMADDIAQEVFIKVFRNMHAFRRDASVKTWLLTITRNTAIDFKRSAFLRKVTLSDWFEERGERHSSEQEVMEQLAVNDMWKQVLLLPPKYREAIILFAHHQLSMKEMADILGVTEGTVKSRLFHARQKLAKMKERNIDGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWF3</accession>
    <name>A0A398CWF3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">recA</name>
        <name evidence="12" type="ORF">D3H35_11760</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the RecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03354">
        <property type="protein sequence ID" value="RIE03354"/>
        <property type="gene ID" value="D3H35_11760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="10">
        <location>
            <begin position="34"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="11">
        <location>
            <begin position="198"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="64"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE03354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="351" mass="37733" checksum="666221EE1DDA8ECF" modified="2018-12-05" version="1">MSDRRAALEMALRQIEKQFGKGSVMKLGENAQMKVETYSSGSLALDIALGIGGFPRGRIIEVYGPESSGKTTVALHAIAEVQRSGGQAAFIDAEHALDPLYASKLGVNIDELLLSQPDTGEQALEIAEALVRSGAVDIIVVDSVAALVPKAEIEGDMGDSFVGLQARLMSQAMRKLSGAISKSKSIAIFINQLREKVGVMFGNPETTPGGRALKFYASVRLDVRRIESIKQGNDVIGNRTRIKVVKNKVAPPFKQAEVDIMYGEGISKEGSIVDIGVELDIVQKSGAWFSYSGERLGQGRENAKQTLKDNKELSWEIEKQIRDASLSSAAVASPGALSEDEEEDSEFGSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX37</accession>
    <name>A0A398CX37_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YhgE/Pip domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03771">
        <property type="protein sequence ID" value="RIE03771"/>
        <property type="gene ID" value="D3H35_09465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017501">
        <property type="entry name" value="Phage_infect_YhgE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017500">
        <property type="entry name" value="Phage_infect_YhgE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023908">
        <property type="entry name" value="xxxLxxG_rpt"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03062">
        <property type="entry name" value="pip_yhgE_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03061">
        <property type="entry name" value="pip_yhgE_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03057">
        <property type="entry name" value="xxxLxxG_by_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="613"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="671"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="706" mass="72141" checksum="9D152E294C48F7FD" modified="2018-12-05" version="1">MLDMSNNSERKGSLLGEFRRMSGNRMAKLSLAGLAVIPLLYSGMLIGAFWDPYGKLGDLPVAVVNEDAGATMDGKAIHVGADLVEELGKKDTFKWSFTNASEAMEGLEDHRYAMAFVIPGDFSSKTATLKEDNPQPAGISYYVDDGWNYLSSRIGDSASETLRADVSKEVTKAYAAAVLDSVGSAAEGLKEASDGASKLADGAKEAQDGAEKLHANLAKLADGTLQLNQGLGKLTGGAATLATGAREAASASGTLAGGLGKLSGAGKSLSDGAAASGQGAASVAAGAEKLSGSGQTLATGAADAKSGSVSVSAGADQLAAGLKQYADAHSDLASDPAFQKLLGAATQVAEGAGKLKQGTAALAAGAEQLADGQRTLSQGAAQLNGGLQQLNTGLSSYLGKVDEASAGADKLAAGIKQLSSGAEQLRNGLGDADSGVRTVTDGASKLTDGSEQLAGGIKKLGDGSSELSGKLGEASKDANALKGGDKTTEMFAEPVSINEHKLANIANYGTGMTPYFLSLGLYVGIMMSTIILPLRDSSGAVSRSGWRWYLSKLALFAPVVLLQSILADTLLLYVMGLEVPNVPLFYAASALIALTFMTILQFLVSLADTIGRFIGVILLTLQLAASAGTYPTELLPAWLQAISPWMPMTHAIEALRLLIAGAPASKLAEPLLILAAFAVLFIALTFGYFHLASKRKGEAFAAAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX60</accession>
    <name>A0A398CX60_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">M48 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_10840</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03584">
        <property type="protein sequence ID" value="RIE03584"/>
        <property type="gene ID" value="D3H35_10840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48_N" evidence="11">
        <location>
            <begin position="46"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="10">
        <location>
            <begin position="210"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE03584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="421" mass="47327" checksum="13177FD5CA550DF1" modified="2018-12-05" version="1">MRNRSAVVRFSLLLLVYAVVMAVYVWYTSPNSVPAAYKGTEADPAAFFTQSQLTDSEMLNAARNWIFFLSGPWEWFIYIALLSGGLARYWRDALERRRLPVYVRFPLFVLLVDAAAFILYLPLRILGYGMSKTYGITTQPISGWIRDKLVAFGIGYVTALAVSAVAFWLISRGGRWWLKLWLLSVPFTLFMMYVQPVVIDPVYNHFSRLSDPQLEGKILELAAKADIPADRVYEVNMSAKTNAMNAYVNGIGSSLRIVLWDTTLKRLNEKEILLVMAHEMGHYRMHHLEWSAAGAVGSSLVVILIGRWLYVRALRKWGEGWGIRSVSDMAALPLLLLLLSVMSFASLPLSNLVSRSAESSADAYAMKLTGSAEGSVSMTQKMAVASLSDVNPPLLVRLFRDTHPNDLERIIAARKFEETHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXC7</accession>
    <name>A0A398CXC7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_01575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05238">
        <property type="protein sequence ID" value="RIE05238"/>
        <property type="gene ID" value="D3H35_01575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="210"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="231"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE05238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="805" mass="92711" checksum="409B70B3D1E8FDAC" modified="2018-12-05" version="1">METKDWRLEQERLERVRNKLQARIVELEPEVAGLRDQATDIRKRFWEEVTINTSTHEDFEESFYTINQQSAVLAERERGHKLLTQQWKSMNRLLPSPYFGRIDFQEDGLDLSEQIYIGVSSFVDEDGLSFLIYDWRTPIASLYYDYSPGLASYVTPAGRIEGTMELKRQFQIQNGQIRNMFDASETIGDELLQQVLGKGADSQMKSIVATIQKEQNAIIRNDKSRMLIVQGAAGSGKTSAALQRVAYLLYKHRQTIRADQIVLFSPNPMFTSYISTVLPELGEENMQQTTFQEYLDYWLGSSLRPEDAFDQIEFVLTAQGTPGYEARLQGIEYKASETFLQALQNYGMWLGREGMRFNGIRVRERDLITAERMRVKFYGYDHSLPLFNRVVLLQEWLLNELASLERMERNAPWVQEELDYLDTEQYAEVFGMLHKERELFDLAELYATVREKMSNKRREDEGDFDFAGREEDLLRRSIVKESFKPLRKSVKKFSFVDVKAIFGQLFVDEAAYRQRTNGAAVPAQWSEICRQTKEKLLRNELFHEDATPYLYVKELIEGVRTNTEIRYVFVDEGQDYSPFQYEYLKKLFPRARMTVLGDFGQAIFMQATSLEAADSPLVRLFGEAETSLVRLVRSYRSTREIVEFTKSMLPGGEEITPFERGGQKPLLTRLDGGEKRDAQILADIAALRAEGFDSIAVITKTAAESREAYESLQIHGGEALQLITKETPGFEKGAMVIPVYLAKGVEFDAVLVYDASPEAYGRANERKLLYTACTRAMHRLHLYTTGDWSPFVQALPVNVYEKAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYI6</accession>
    <name>A0A398CYI6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_03880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04887">
        <property type="protein sequence ID" value="RIE04887"/>
        <property type="gene ID" value="D3H35_03880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="248"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="283"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="496" mass="53944" checksum="1A7AD9BD6031890E" modified="2018-12-05" version="1">MSGINKSFAGVPALKDVDFAVRGGEIHALLGANGAGKSTLMKILSGAYECDSGDIELNGRRLDIRSPADAKKAGIHCVYQEVDTSLVSHLSVAENIMLDRLASSDGSGWIRWRALYKDAEQVLARLGLQLPVRKKAADLTLAEKQLILIARLFVQDAKIVILDEPTAPLSLEEANRLFKLMQGLKEAGIGIIFISHRLPEVFRICERVTVMRDGQRVMTENAESTNVGEVVRTMLGKSFEDEYPKLEAEIGDTLAEIQGLAAGHRVRGVDLRVRSGEIVAVVGLVGAGKTELSRLLFGADAPEEGSVRLNGELVKPRSPADAVESGIVLVPEERRKEGILVQHSVLHNLSLPILQTLSRFGFLSGVKEKRNAQQIIEELGIKASSPQLETAFLSGGNQQKVAIGKWTKTDAKLFVFDEPTKGVDIGAKRDIFRIIGQLAQQGKGILYLTCEFAEALGLADRILVMCDGRIVKEFARGEATQEDLLYYASAGREEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZS1</accession>
    <name>A0A398CZS1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate 5-kinase</fullName>
            <ecNumber evidence="8">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyl kinase</fullName>
            <shortName evidence="8">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proB</name>
        <name evidence="10" type="ORF">D3H35_04235</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04701">
        <property type="protein sequence ID" value="RIE04701"/>
        <property type="gene ID" value="D3H35_04235"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="275"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="167"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="209"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="374" mass="39882" checksum="DDC2B9D04454366B" modified="2018-12-05" version="1">MAKRIVVKIGSSSLTSDEGGLNRDKVRFFARELGALQAADNQVLLVTSGAVAAGFRRIGYTSRPKLMHEKQAAAAVGQALLMEAYQEAFGAEGIAVAQILLTRPDFSNRGRAQNAHRTIEELLKQRVVPIINENDTVAIDELKFGENDSLSALVANLVKADGLYILTDMDGLYTADPRISPEAVKIERVDVISDELYRIAGGAGSSVGTGGMRSKIEAARIAMQGGVSTFIGSVADEGDLKAAFAGSGRGTYFSSSLHSLSSKKQWIGFLSVPQGRIVVDNGAEEALLHGGRSLLPAGVSSAEGDFHPGDVVEVVDADGRVLGRGLSNYASWQITAVAGLSSEEARRRIETTRIEVIHRDEWVATPIMKEAESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0M4</accession>
    <name>A0A398D0M4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_04315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04714">
        <property type="protein sequence ID" value="RIE04714"/>
        <property type="gene ID" value="D3H35_04315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017303610" evidence="7">
        <location>
            <begin position="36"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="326" mass="36359" checksum="38B42224FC9DE5A8" modified="2018-12-05" version="1">MLALIRNETIKVWKKKRFAVIVLILCVLIPVFVYAQIKIAENNREKFNEDWRTQLQNRITDNTRALGSDRIPEEWKKWRRALVQQLQYYLDHDINPETPNGVTFTKNFMDNAVTLFIPLMVLAIASDLVSSERSTGTIKMLLTRPVRRWRILFSKLAALTLYVSLVVATTYVLAYLISGLAFGFAGWGEPVFVGFRVNGGDVDTSGVHAITQAAYLLMQAGLVWFSSMVVAIIALMVSVLVRSTAASFVTMMATIIAGTILANMASSWQSAKYLFNVNMELTTYLRGTPPPVEGMTLGFSLIVLAIWAAAALTTAFAVFTKQDILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D115</accession>
    <name>A0A398D115_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_02085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05181">
        <property type="protein sequence ID" value="RIE05181"/>
        <property type="gene ID" value="D3H35_02085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="101" mass="12032" checksum="1EBA919DBBD51262" modified="2018-12-05" version="1">MKLKIAEVILDNGDIDLIFDELTKREDFKLILDKYLEIKEVRLVKETEDEFKKACLLETDNFQFVLVYDSDSFVWNYMYAVKRENHGLLKELCRSVAEFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1S4</accession>
    <name>A0A398D1S4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000004">
        <property type="protein sequence ID" value="RIE05451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05451">
        <property type="protein sequence ID" value="RIE05451"/>
        <property type="gene ID" value="D3H35_00340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="100" mass="11163" checksum="22CDC36D9B4C8657" modified="2018-12-05" version="1">MKERTERSFHRHRFIGEGSARIHVFELARSTMNSEELEWSEHGAKGSLRLPADPSLFSCIAAFLLPDKKKARSIAEAMTVPSDTRIPGPVNALNEDEIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCC3</accession>
    <name>A0A398CCC3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00826">
        <property type="protein sequence ID" value="RIE00826"/>
        <property type="gene ID" value="D3H35_26970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding_C" evidence="1">
        <location>
            <begin position="74"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="189" mass="20965" checksum="D3ADF32960E766A2" modified="2018-12-05" version="1">MLPGNVYFGRRCLKRLLESTGAHSGEIRSQPVRAWRADVPDGRPGALAADGNIEYLGRIDEQVKVRGHRIELGEVESALRSHESVKEATVIARKDEEGSAYLCAYFVANGNLGTAELRKRLSEMLPQYMIPSFFVQVEQMPLTPNGKLDRKALPSPEGNYDFGVANEAPRNELDKKLFPYGDKCSAANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCY2</accession>
    <name>A0A398CCY2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_21535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01036">
        <property type="protein sequence ID" value="RIE01036"/>
        <property type="gene ID" value="D3H35_21535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="298"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="362" mass="41033" checksum="2D1781794D1AF915" modified="2018-12-05" version="1">MNKARLDQLSELLGAPVATRTITNAEWEKDGGSKRLEVGSVCTLKQGARLVIRLEGSEIQVLETTAKLTPLERELLGWALKQGVKPGSAGSNLERQSKRLGEWIGQCISSGEWRTEVPDRMELYNRLFDGMIPFLLYCEQLEDKEPSYAELEKTIRSFIEDDTLLIPLREHEWLVLGSDRLLAEVETLDDDSAIDEEIKETLSSLASGLHQLVTGEWGGDCHVAVALPIVPSESVVYTVANLRETIYLGRKFHMGMQVHLPWLVHLEKLLNSIPEPVRAKFVEEMLGRSDMFTDVETVATLDVFFSMDCNVSETAKKLFIHRNTLLYRLDKLKQESGLDVRSFNDAVMMRILLLLYKVTKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD09</accession>
    <name>A0A398CD09_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00593">
        <property type="protein sequence ID" value="RIE00593"/>
        <property type="gene ID" value="D3H35_27730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025716">
        <property type="entry name" value="Post-transcriptional_regulator"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13797">
        <property type="entry name" value="Post_transc_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="77" mass="8908" checksum="5B3FB1FF2122A04E" modified="2018-12-05" version="1">MNKTIESLCESKAEEFKLIGYDHVSGADVWECVSDKYHVKGTPALHVIVNDILSLKVNQFMNFITLNMYRGDYRPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD20</accession>
    <name>A0A398CD20_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000051">
        <property type="protein sequence ID" value="RIE00610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00610">
        <property type="protein sequence ID" value="RIE00610"/>
        <property type="gene ID" value="D3H35_27510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="61" mass="6739" checksum="5E5C3EB3B6A28EB6" modified="2018-12-05" version="1">MTERHGLRLAVVVLFVPVHQIDEDRIDSGCEVAEARTLTVRLALNGSLMNSLSATPFANRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDL8</accession>
    <name>A0A398CDL8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BofC_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00525">
        <property type="protein sequence ID" value="RIE00525"/>
        <property type="gene ID" value="D3H35_27665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015050">
        <property type="entry name" value="BofC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038117">
        <property type="entry name" value="BofC_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08955">
        <property type="entry name" value="BofC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BofC_C" evidence="1">
        <location>
            <begin position="144"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="235" mass="26287" checksum="13967103A557514A" modified="2018-12-05" version="1">MGIPVLRSRVMKELKKRLKRKKWPVWSLGLVAAIFLISAAVGAASVYLIVSSGKTERVAEAWSPVISADEPGVDATPRERTLHSLSRWNGEVEVVLHRVYLCGEETRMLGRHATSEARDLLISHLDWDAKFDRTGTVVMEEKIDDLSPACRSTSYIGLDEDGNLSLFDGPPRKDNVVRTFFQLDVGLLESSLSKERLHELANGIKVSDKDEYNSVLSTFSDYALERSESVLQPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDN5</accession>
    <name>A0A398CDN5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00823">
        <property type="protein sequence ID" value="RIE00823"/>
        <property type="gene ID" value="D3H35_26955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="5"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="294" mass="33949" checksum="BE2AF072DB6C7556" modified="2018-12-05" version="1">MEPLRLQYKDFSEWQRNVFLNEQVAKQERFWLNRFSSEIPKLALPTDYPRPSYKSYEGDQVGFILDEKTTMSLKQLSLETETTLYMVLLSAFTILLSKISGQEDIVVGTPVAGRTHVDLANIMGIMINNICMRNLVDKDKIFMEFLKEIRQNTIEAYDNQTFPFEMLVEKLGVTAEPSRSVLFDAMFGLNSNLYSNSEHDTSNIEFIPSAVGNGTAKYNLNLQGNEAQNEIQLTMEYSIKLFKRETIIRLVEDYQKILLQIIGDRSIKIKDIGIGDPFKIPKRHSSMEMVDFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE37</accession>
    <name>A0A398CE37_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">tsaD</name>
        <name evidence="8" type="ORF">D3H35_25780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00973">
        <property type="protein sequence ID" value="RIE00973"/>
        <property type="gene ID" value="D3H35_25780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="7">
        <location>
            <begin position="40"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="150"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="378" mass="40033" checksum="5909A0751802131B" modified="2018-12-05" version="1">MISDQQKREQSGENASPYYILAIETSCDETSVAIVRDGREVLSNVVSSQIETHRRFGGVVPEIASRKHVESITVILEEALKVAGVGLADVNAIAVTQGPGLIGALLVGVVAAKSLALALDVPLIGTHHIAGHIYANRLIGEIEYPALALVVSGGHTELVLLEREGEFRIVGRTRDDAVGEAYDKVARALSFPYPGGPHVDKLAQGAEEEIELPRAWLEPDSYDFSFSGLKSAVLAEINRAKMKGEPVREAALARGFQNSVIDVVTTKAMKAAAEFGVRQLLLCGGVAANGGLRAKLSELCGKARLPLLIPPMSLCSDNAAMIASAADLKWRRGEFTSLDMKADPMISLEGWSVGKEPSPSLSESAAGNSVIGNSVFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE75</accession>
    <name>A0A398CE75_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_24285</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01476">
        <property type="protein sequence ID" value="RIE01476"/>
        <property type="gene ID" value="D3H35_24285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="138"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="138"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="246" mass="28155" checksum="E3AD63FAD3EE44EB" modified="2018-12-05" version="1">MPGKILVVDDERPIADILKFNLEKEGYEVVCAFDGEEAVRLAFAEEPDLILLDLMLPEKDGMDVCREVRARLSTPIIMLTAKDAEIDKVLGLELGADDYVTKPFGTRELLARVKAHLRRTRKLDAAKEEDAVSPESERQGLRLFNLFIDTDMYVVYKNGQPLDLTHREFELVHYMARNSGKVMTREHLLQAVWGFEYFGDVRTVDVTIRRLREKIEDDPSRPEIIMTRRGLGYLMRNPKMNGGLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF49</accession>
    <name>A0A398CF49_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA gyrase inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01200">
        <property type="protein sequence ID" value="RIE01200"/>
        <property type="gene ID" value="D3H35_22650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AraC_E_bind" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="161" mass="18177" checksum="366CF6BC0CA909E6" modified="2018-12-05" version="1">MNITIEILPKYRIAYVRQVGPYGPDNTQAMEKLKQWAKGNNLLAESAIILGVPQDNPETTLPEKCRYDACIVISKDYPVDDSICESELSGGTYVICKIKHTEEDIQKAWNEIFAYLQNSGYQIDNKPIIERYTGVMINNDFCEICVPIKGTPGLRLASRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFE1</accession>
    <name>A0A398CFE1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000051">
        <property type="protein sequence ID" value="RIE00612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00612">
        <property type="protein sequence ID" value="RIE00612"/>
        <property type="gene ID" value="D3H35_27520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="152" mass="17541" checksum="41679C4BE5060E42" modified="2018-12-05" version="1">MLYLAPPYYMINRVSVFRDHEDPLQWYYLPAPPRLTEVTDEQTGVSVPQLQVIQFRSGPDSGGFLNFDVNLGVDPDVLEEIRDEIKRSEHLRESPRLAPVPLIDGTVKLMLFDKQTAMRHRLQDRRYLSLLASAITRSLPCMETISRHSRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG11</accession>
    <name>A0A398CG11_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Urea ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">urtA</name>
        <name evidence="3" type="ORF">D3H35_23745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01385">
        <property type="protein sequence ID" value="RIE01385"/>
        <property type="gene ID" value="D3H35_23745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06355">
        <property type="entry name" value="PBP1_FmdD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017777">
        <property type="entry name" value="ABC_urea-bd_UrtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03407">
        <property type="entry name" value="urea_ABC_UrtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017466684" evidence="2">
        <location>
            <begin position="22"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="424" mass="45973" checksum="6B687CCFF3DDE361" modified="2018-12-05" version="1">MKKSNWLKGFVLAMTASLVLAACGKDNNENSGASSSASPSSSSSSPTASGGEKVKVGILHSLSGTMAISEVTVRDSELMAIKEINAAGGVLGKQIEPVIEDGASDWPTFAEKARKLLSEDKVATVFGGWTSASRKAMLPVFEELKGLLWYPVQYEGLESSPNIFYTGATTNQQIVPSVDYLLEKGKKKFFLLGSDYVFPRTANKIIKAQLAAKGAETIAEEYTQLGHTDYTTIIAKIKQAKPDVVYNTLNGDSNVAFFKQLKDAGISSKDLMTVSVSIAEEEVKGIGADYLVGHLVAWNYYQTTDTPENKKFVENFKKEYGADRVTSDPMEAGYTAVYLWKAAVEKAGSFEVDKVKEASKGIEWNAPEGKVTIDGDNQHIYKTVRIGEIQADGQITELWNSGSPVKPDPYLKTYDWAKGLSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGG2</accession>
    <name>A0A398CGG2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_13600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01823">
        <property type="protein sequence ID" value="RIE01823"/>
        <property type="gene ID" value="D3H35_13600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036244">
        <property type="entry name" value="TipA-like_antibiotic-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012925">
        <property type="entry name" value="TipAS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07739">
        <property type="entry name" value="TipAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89082">
        <property type="entry name" value="SSF89082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="248" mass="28511" checksum="B77DDE9E906AB7BE" modified="2018-12-05" version="1">MSMRVKEVAELVGISLRTLHHYDEIGLLAPDETTDAGYRLYSDANLETLQQILFFKELDFPLKKIKEIMSSPVFDREKAMELHRKLLMEKRSRIDAMIATIEKTVRHARGEIQMTNKEKFEGFDFSRTPYEQEARERWGDEAVDEANAKVGGLSKDKQQEISDEMNAIYFKLATLRGGSPESEEAQVAIKEWYDFLNQMGSYSPEAFKALGQMYVDDERFTANIDQFGEGLAVFMRDAMAVYADKSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGQ8</accession>
    <name>A0A398CGQ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-directed DNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_16950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02396">
        <property type="protein sequence ID" value="RIE02396"/>
        <property type="gene ID" value="D3H35_16950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000123">
        <property type="entry name" value="Reverse_transcriptase_msDNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00866">
        <property type="entry name" value="RNADNAPOLMS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="1">
        <location>
            <begin position="282"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="322" mass="37698" checksum="7234A32F14C3A561" modified="2018-12-05" version="1">MEKKINMADYMVRYIVTKGKRRRIVTYGNEEKRQEHNEIKLFLEEKLIFSKFTKAYIAYSSIYKNAKAHMYNDIFIKYDIEKYFDSINHKILVRILHEQLNLGQEKEIYTIFETSELVGNCIFGKKGLPLGLITSPVLSNIYLKTFDNILYGKLKKMKLENVIYTRYADDLTISFKNSSRKSLEDLDHVFSEIESLINLQLKNYKLKLNANKKSIISLDVSNHVRITGISITKLVTGKRRLSVGKKKVIKLFDDALQLYYKKIVDADELSNEDLYNIQRVKGMESFVLSIHKTGYNHMFSEKMQDKLLNLGFKSLHELIESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH50</accession>
    <name>A0A398CH50_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02536">
        <property type="protein sequence ID" value="RIE02536"/>
        <property type="gene ID" value="D3H35_17755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="278" mass="32720" checksum="FF37FA0269A21BAE" modified="2018-12-05" version="1">MAGTSAQQWYEVPFFRRLAGTSAQQWYEVPFFRRLAGSSAQQWYEVPFFRRLAGASAQQWYEVPFFRRLAGTGAQQWYEVPFFRRLAGASAQQWYEVPFFRRLAGTGAQQWDEVPFFRRLAGSSAQQWYEVPFFQRLAGTGAQQWYEVPFFRRLAGASAQQWYEVPFFRRLAGSNAQQWYEVPFFRRLAGTGAQQWYEVPFFQRLAGASAQQWHEVPFFQRMAGTNAQQWYEVPFFRRLAGASAQQRYEVPFFRRLAGLNRPTENLPDIPSDRFSVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH74</accession>
    <name>A0A398CH74_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_13610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01825">
        <property type="protein sequence ID" value="RIE01825"/>
        <property type="gene ID" value="D3H35_13610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="294" mass="33128" checksum="3886AD3EB838794A" modified="2018-12-05" version="1">MVGQSVGARRNKALTVTMAGEWREQRRNKALTVTMAGKCEGVRRNKALTVTMAGEWREQRRNKALTVTMAGKCEGVRRNKALTVTMAGQSEGARRNKALTVTMAGQSEGARRNKALTVTMAGQSEGARRNKALTVTMAGEWREQRRNKALTVTMAGQSEGARRNKALTVTMVGQRRKRRRNKALTVTMAGEWRERAEIRHSQLLWRAKVRERAEIRHSRLLWRAKAREHAEIRHSQLLWRANGGSGAGIRHSWLLWLANRGDSAGMRRANIRESPSFCLMSQKEVVSCLLGVQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH94</accession>
    <name>A0A398CH94_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VWA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01342">
        <property type="protein sequence ID" value="RIE01342"/>
        <property type="gene ID" value="D3H35_23505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="251" mass="26952" checksum="41F06D6D77DC8E26" modified="2018-12-05" version="1">MRQILLITDGGSNVGESPVVAAARALTEGVTVNVVGVVDESAIGEHGAAEIAEIAKAGGGMSRVVSTRQLSQTVQMMTRQTVAGTIRTAVNQELRQLFGLDSVGALPPPKRAEVVKVMEEMEETSPLRIVLLIDASASMKPKLHSVEDAIRDLVLSLQARVGNSAVAVFHFPGDYSHLPCVMDCDWTTDSRRISSLFARIQMKGTTPTGPALMQVVDFIRDTCGNIKTELMEAPPQLRRGDPDGVRSDYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHI4</accession>
    <name>A0A398CHI4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02676">
        <property type="protein sequence ID" value="RIE02676"/>
        <property type="gene ID" value="D3H35_18625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="95" mass="9862" checksum="6021FCAD69FBA89D" modified="2018-12-05" version="1">MRKGNGLALLLIVFGLLLILGKLGIFGFLMGLLIPVLVIGLGVVAWSNGSRLLGGILGLIGAIMLLGKLSFLFVWVAAIALIIFGVSMLGKKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHP5</accession>
    <name>A0A398CHP5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02756">
        <property type="protein sequence ID" value="RIE02756"/>
        <property type="gene ID" value="D3H35_19125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="524" mass="57499" checksum="C9F9062EBC6E98C3" modified="2018-12-05" version="1">MKIRYDLFGLETGGEVRSFKSKWPLWASFAFVLLLGGLYLLREGATPESIFAIAGLAAGGIAFFYAMAHAASLRTNPFREWWLTLPVSRTKLVRAKMVSLLIVSGLIGIAFWLVATLAAIISLLFGETSIGAATPGSVLTAAGAYALFTVAILPLGVSLGFLLLWMYGGLRRYLLIPYLFVLFPFGLFVIVLDSGEAVQKWLAPEAVLVYSLIVGAAGSVMYRLTRAVVSSQGMSDLAAFRIGDVAKSWREPRKRAETKIGHFTPETGRFRILYAYERSRYAYATSLRPVIIILRSLAVLLAVAGYFSFGSREGTVGLVTALMIFAFIGTNIMCSLSNVLPEQRARLTWWLMFPVGRKKLLLARVAAIWTTVYRIAFAGLLCIIAGGAVRYAVNGHYPGDAKSDAELLAYTVLFYVVLSTLFAFLLQVQSYTLRNRVIAYLYIPILIGSYWVPTAVSNRLINDEMIAAGVGSYQWTILLAVIVIGTPLAVAAFFAGAKTLHLFLVDPKAQQRSASKEGRLLRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHU7</accession>
    <name>A0A398CHU7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-1-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.33</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfbF</name>
        <name evidence="2" type="ORF">D3H35_19530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.33" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02826">
        <property type="protein sequence ID" value="RIE02826"/>
        <property type="gene ID" value="D3H35_19530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047343">
        <property type="term" value="F:glucose-1-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02524">
        <property type="entry name" value="G1P_cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013446">
        <property type="entry name" value="G1P_cyt_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47183:SF1">
        <property type="entry name" value="PTHR47183:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02623">
        <property type="entry name" value="G1P_cyt_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="258" mass="29381" checksum="7ACA3D22C9B59D42" modified="2018-12-05" version="1">MKVVLLAGGYGTRISEETHLRPKPMIEIGDKPILWHIMKIFSHYGMTEFVICLGYKGFVIKEYFARYYLLESDITFDFKKENEMIVHQHTAEPWKVTLVNTGLDTMTGGRLKRVQPYLEGESFMLTYGDGVADIDIAELAAFHSRHGKIATVTAVQPSGRFGMLDLQEDGSVAGFQEKPKGDGGWINGGFFVLRPDIFDYIEGDDTVFEQGPLIRLAQEDQLQGYKHDGFWHPMDTLRDKTYLDALWKTGNAPWKMDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHV2</accession>
    <name>A0A398CHV2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02373">
        <property type="protein sequence ID" value="RIE02373"/>
        <property type="gene ID" value="D3H35_16800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="467" mass="53885" checksum="C25CE083CBBB80DD" modified="2018-12-05" version="1">MQVSNFKPTLEIPFYYPCNLPLIHEVLKRQGSTSSLSLVANSRFYGLPAYCSTGHIRWYFNRLEYDDPIWTMTEKVEFSSFEEGLDRIRQRTNEEEMFLVTGTSYFLPYCEDYLNPKYIEKLTEPNSRLYLVDHWLAVYGIEDDHVLVYDPVPSRYSGPLSMQAFHDFWKGNKSIPELADAKRKEELFSYSSLDVKAKRQLTPELYKEELLRTLATHSYEFLSGTELKEGDRTYYFGHAVTLQLLKRIHLTTTADDAAGSVSGFLFDMRWSRYFFRDLLQDVASSHGSVYVSIAAEFSEIIEQWEKAHKMLKLYEVKNKSKAELASMLGSFVTSLSEREYRLYERIWSETRNVGLFDKRHAQEDGSSAKQKEALERIVLESCLEINRFHDGRIPVELGLRAPLYGRNGNLDSLGLVSLLTVVEHGIMEELGIGLTLSEEQSPALPDGPFRTVESFVDFILDRMPEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIA6</accession>
    <name>A0A398CIA6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_20620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03006">
        <property type="protein sequence ID" value="RIE03006"/>
        <property type="gene ID" value="D3H35_20620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="15"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="417" mass="45114" checksum="D40C4B06B7C6EDFB" modified="2018-12-05" version="1">MIKSGLLSEPKHRKLLFSAGLSWLFDAMDVGMVSFIVAVLAVEWQLESQQIGLLTAINSVGMAVGAAVAGSLADRYGRRSILLATLLLFSAASGLSALAAGFAVLCTLRFVAGFGLGGELPVASTLVSESVPPNDRGRAVVLLESFWAGGWIVSALISYFVIPHFGWRMAFAIGALPAVYAIYLRTSIEDSPSYARLRSDKLSFGDRLASLWSKKYRLSTFTLWILWFTVVFSYYGMFLWLPSVMMLKGFSLVKSFQYVLIITLAQLPGYFTAAFLIEKVGRKFVLVSYLLLTAASAVWFGRSETEGMLIAAGICLSFFNLGAWGGMYAYTPELYSTAIRSTGVGFAAAFGRIGGVIGPYLVGLLVGLNIPIATIFLVFFIAIVIGALVVLFFGQETKGIDPDRSAIEDGLTEIKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CID9</accession>
    <name>A0A398CID9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000051">
        <property type="protein sequence ID" value="RIE00608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00608">
        <property type="protein sequence ID" value="RIE00608"/>
        <property type="gene ID" value="D3H35_27500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="127" mass="14320" checksum="ADBBD7DD8A3671D1" modified="2018-12-05" version="1">MTYSANIRFKDGTFEEVPTTVSDRNTIMLGDVALTQSIQLVPDLINFDLVKLVKVTLHYADEANGIDETKDFLFKKRPRSEVGVYLQRQIQASLRMESVLLHGRRSVKNIEPGNTSEKTIVLPETPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIV3</accession>
    <name>A0A398CIV3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_22205</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01129">
        <property type="protein sequence ID" value="RIE01129"/>
        <property type="gene ID" value="D3H35_22205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011623">
        <property type="entry name" value="7TMR_DISM_rcpt_extracell_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07695">
        <property type="entry name" value="7TMR-DISM_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="443"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="712"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE01129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="933" mass="103586" checksum="DBB75072D396A5A9" modified="2018-12-05" version="1">MSLKRVLLIVGAFIVALTSVRLAWLFLFMPPGHARAVQGLIDMRDWDFGSERAVSLNGEWEFYPGRFLIGQSKESLSVPEGGQIAKVPGRWNEAMSKENGGTGRADSTFGYGSYRLRVLVQPDRERIYAIRMPVVTSSTELYVNGRLVGHSGTPASSREAYTARSVPYTASFATDRDEIEIIVQVANFDDRIAGGIVWPIKFGTDSAVDRSANFSIGLQLSVCLILLAHSVYSGILYVMGMRQKALLYFALMNVCAIVSVLIDDSRLLPVWSSMDDEWIMKTYYMAYLGIAAFLFQFGRHLLLPEKKKIWWLRAYTAICAAYAAAVPLMTIRWLTLADYIHTLLTMIPFLVVPALAFRAVVRGQKDFIYILLGVTAVMLSTVWGVVKNTGWMEMGFYPFDLIATFIGFALYWFKSYLRSSAQTARLAERLLEEDKRKDQFLVQTSHELRNPLHGMLNIAQTVLDDGGRSDEARNRDNLKLLVAVGKRMSYLLNDLLDLTRLKENRVHLQLRDVRVQAIASGVLDMIRVMIGDKPIRLANDIPEAFPPVKADENRLIQILFNLLHNAAKFTNEGTIKVDAYVRDGMAYICVSDTGIGMNEAALGALFEPYEQGGLDEPDGASGLGLGLGICKQLVELHNGTIEVSSSPNRGTDFSFSLPLSESTAPHGDETPSTSAFIVLQETAAGLAEELAKDGNNPALVVDAESASADRSSLLAVDDDPVNLSVLQSVLASENYDIVTCTSGEEALARLPSREWDLIIADVMMPNMSGYQLSRAIREVYSLSELPILLLTARSRPEDIEVGFQAGANDYLTKPVAANELKSRVRALTDGKQSFRKRLRMEAAWLQAQIQPHFLFNSLNAIASLSEFDTTRMRALLEAFGKYLRVSFDPGIWIGSFLSGRSWTLCEPTYSLRRNDSRIGCGSSGRSMNIWAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIX4</accession>
    <name>A0A398CIX4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_18610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02673">
        <property type="protein sequence ID" value="RIE02673"/>
        <property type="gene ID" value="D3H35_18610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="2">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="110" mass="12153" checksum="3B80145055C08C9F" modified="2018-12-05" version="1">MAVLLATDADFDSKVKREGITLVDFGAKWCPPCKALEPIMDELDALFGGDIDILKVDVEQSPHTASTYGVFSMPTVILFKDGEPMEKKVGLKPRSAYEQSLAKYREDVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIY5</accession>
    <name>A0A398CIY5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_12735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000038">
        <property type="protein sequence ID" value="RIE03256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03256">
        <property type="protein sequence ID" value="RIE03256"/>
        <property type="gene ID" value="D3H35_12735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="43" mass="4796" checksum="318A2E652227B52D" modified="2018-12-05" version="1">MNGCFLWQLVDSGIPTIDIGFPARYSHSAVEVCDMQDLEQLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ78</accession>
    <name>A0A398CJ78_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02395">
        <property type="protein sequence ID" value="RIE02395"/>
        <property type="gene ID" value="D3H35_16945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="393" mass="46370" checksum="A69357AC730AF745" modified="2018-12-05" version="1">MSFFFNESVVINNPLRIFFLCGSNFVKNPQQVILNDEKYLIKDKRIVLQKFLESTYVGKNFRSIILEDKFMFSDNSRRHLNYNDINLKSLKSIELLTSLFSDFVLIIHESYSTAAEIGMFSTVESINEKLIILTPNEYSIDEDYFSGFMRLAYQNPIYSKHNIKRIQYNPGTYQFHISKYSRKFHTFFIENEIKGMLANSLSSCFNVLCEKNISFRNKANIYDRPSNYYQLVESSKIQVNLDSNDLLAYLISLFNVDQLRREFILNVDMTCLNVDSTSNRRKLLFKEGTRIVGKQFKDVIFNTLKVQIPNIETKFGPIEKIDRFIDFNVRNQVVNLYESISYFLYILFALSYININGDNTRFSISNTFEPVYREYKGLLHESNSTTKKIWRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ98</accession>
    <name>A0A398CJ98_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="3 9">2.7.1.180</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_15740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ApbE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="3 9"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02192">
        <property type="protein sequence ID" value="RIE02192"/>
        <property type="gene ID" value="D3H35_15740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE02192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="325" mass="35557" checksum="33E92B8DC40FEEDE" modified="2018-12-05" version="1">MTGLGIEKVVQTDRFRAMNTDVDTALLVDRYDERPFLEVRQQFASSENRFSRFNPDSELSRLNGRHGRPCRISAEMAAILQAAAAYRKLTGGIFDPAILPELSSAGYNVSFEKMTERTELPKPDEKARPMELRGWQLFPRAGLVRLRRGTRLDLGGIAKGWTVDRVSEGLIGRRIRAGQLNAGGDLRVWSEPGLPAWEIEAALPDGFASNAPSFRFALRNGAAATSSTLRRQWATPGGNRHHLIDPRSGLPAASDTVQCTVVGTTAAEAEIAAKTVLLLGSEDGLRWLERTFPLCDALLYKQDGTAIGVFGKHGDAEWKEGGGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJK6</accession>
    <name>A0A398CJK6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Stage II sporulation protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_19895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02883">
        <property type="protein sequence ID" value="RIE02883"/>
        <property type="gene ID" value="D3H35_19895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="378"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="614" mass="67900" checksum="CFAFF47D39C749BD" modified="2018-12-05" version="1">MTKEKKRRLALYDGSVFKVMLLAAVLLVFSTALVGFLSYRITEGEVIKKLKTGDLSRIAQAVSGRVEGRIDRALETSQMLADDPAVVKWVRGGEADDELGRLILEKLSRIPGAYDYTNSFIVSAVSNRYWSESGKVLQTLDRSKEDDKWFYETLEAGRKTNIVVDTNARRKDTFVFANVLIGTADKPIGVAGVGLSLSKLAGNFASYGNGGGRRLWLVDVDGKIQLSGDPEQTGDYVSAYLSEETRNELAESESGRELVLETKDENGRMYDMISYPIRSSDLRLWVQIPRSETTGFLDTIKVNTAIAAIVTLILIVFLFANVSRKLADPYKRALRMNEELEMLVEGRTEELGRKNREMTDSIGYANRIQRTVLPSEADLNAAFSEHFVYWKQRDIVGGDFYWLKKSGEVTWVAVGDCTGHGVPGALMTMLSVSLLDRIAAVGEEKSPGRVLAKLNVLLKDTLHQTDPEGLTDDGLELGLCRIEGNKLTYSGAGIRMLVAGEDGVRIVQGDRKAIGYRRTPESYDYADHEFAADSGSAYYLVTDGVIDQNGGPKNVSLGKTKLKNAIESFGAMPLLDQGRQLERELAIYMGQEPQRDDMTLLAFRLAGRSGGREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJN1</accession>
    <name>A0A398CJN1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02555">
        <property type="protein sequence ID" value="RIE02555"/>
        <property type="gene ID" value="D3H35_17865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="289" mass="31038" checksum="44465284A41101DB" modified="2018-12-05" version="1">MSTLNKDLARAEGVFWNSEQFTGSWWQDPNKLVVAVNAIANEVSVNGSISLPEVKYTNKIKALQRVSGALMTGEWGVGGPLLDLQGAIQAIMTKYHIDGDPKVLDKGNLEAILDRYSKGLIGQKGGDFLERTGIGYLPYEAVYGLLGLTSMRGRASSAGVGNAAQGTETFYRTMSKADYETFLKTGKVPATSETFISPTRSFSEGYNGVIVEFKVKAGTTNSLANIGVRDSSAIVKDAYGNMPTVGKGWTSNNAYFKGEDGQINIGLGKGKALDTFNDNIVEYKVVGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJS6</accession>
    <name>A0A398CJS6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_22020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01098">
        <property type="protein sequence ID" value="RIE01098"/>
        <property type="gene ID" value="D3H35_22020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="20"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="465"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="516" mass="57853" checksum="0D0DB14216F88B72" modified="2018-12-05" version="1">MFPFFRIVVSSFWQHKVKTALLLAALLVELAYESFMPLSFKFIIDFAIVPRKYSLLLFILILLVSGALASVIIGIFRDRMFTRLGARIVSDYYKQLFKKLQSLPADFYHRVNGGDIVSRFNNDLLSIDAFIMLIPYAILSVMGLLFNVAILFFLQWQLALIAVIGLPLCLIGPKWFGPKAFEDSYRLKEEQAELTTVVQENVSAQPVIKAFGLQPLFIRRFDDRMVRYAKLAGQSSFSSFLIDRTTNMGTMLLNLATICAGALLAYFEILSIGSLLAFSSILISLSYLVAAVTWLAPQLIQAASGMQRVREIIEERPSLEDSEQALDMPLFHRAIEFKDVRFSYTPEQRSLNGINLTIPKGAYAAFVGASGSGKSTIINLLMRFYDPSEGSVRYDDTDIRDIKLQSLRSQIGIVFQESFLFRASIRENIRLGKPEASDEEVVQAARSAEIHDFIMGLPDGYDTDVGERGAACPADKDSASPSLAPSFGTRLSSSWTKQPPRSIRLRNRRSTRRCNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJS9</accession>
    <name>A0A398CJS9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NDP-sugar synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_18150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02605">
        <property type="protein sequence ID" value="RIE02605"/>
        <property type="gene ID" value="D3H35_18150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="347" mass="38422" checksum="672CA45679900E0C" modified="2018-12-05" version="1">MKALFLAGGLGTRLRPLTEHLPKPMALVGNRPWLEHLLLHYKAQGVDEFVIAVKHYRELIETLLGDGSKYGVRIDYSVETELLGTAGAIKNAEKLLADRFIVVNADIIHQVDLASALRFHDEHGGAATICLTEVDDPSHYGVVDQAGNGKIVRFVEKPKKEEAPTNRINAGIYIMERRALDHIPAGRPVSIEKETFPLLIENGSGVYGHPIGGYWMDMGTKVRYRQLHWDLLDRRFPLAIGGKDSDDNGIWIGDNVRVGQGVLFVPPVMIGDDVTIGDRSIIGPYAVVGNGTRIGSHVRLSQSILWERCKIRTGAQLNECIFGTGMQVGPHILHEAVCNRTLEVHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJT8</accession>
    <name>A0A398CJT8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma B factor RsbW</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsbW</name>
        <name evidence="2" type="ORF">D3H35_18205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02615">
        <property type="protein sequence ID" value="RIE02615"/>
        <property type="gene ID" value="D3H35_18205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="12"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="146" mass="15857" checksum="B7DDF935045CD75D" modified="2018-12-05" version="1">MILEGQVTLTVPARAEFIDIIRLNLYGFATKMKFSFEEIEDMKVAVSEACNNAVLHAYGAEDGIVEVTFVASEEELVITVRDRGVSFSPSGIGEGKTLHGKTIDEIQSGGLGLYLMQALMDRVEVSNENGTAVTLAKRRAQSKETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK65</accession>
    <name>A0A398CK65_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Resolvase/invertase-type recombinase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_21245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03103">
        <property type="protein sequence ID" value="RIE03103"/>
        <property type="gene ID" value="D3H35_21245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="5">
        <location>
            <begin position="41"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="4">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="92" mass="10239" checksum="29E6728041D5A1C2" modified="2018-12-05" version="1">MGTNIADNLGKKRVASEPITYSVVGIISDDAQQTNVNFAEVFYARVSTEEQAKRGYGLSDQVRRCRKKITELSGDNVEVFEYLEEGVSGEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK70</accession>
    <name>A0A398CK70_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_17790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02542">
        <property type="protein sequence ID" value="RIE02542"/>
        <property type="gene ID" value="D3H35_17790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024478">
        <property type="entry name" value="HlyB_4HB_MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12729">
        <property type="entry name" value="4HB_MCP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="206"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="278"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="564" mass="59631" checksum="03854CDD97AFEDA5" modified="2018-12-05" version="1">MTEMNVSRKMIAAFLAIAFTVAAASGLSYLYLQRVNDSYREVLAREATVSDRVFGIETLTERQKGVLFRYLTAPSQQLEKELRAAWEALNVEIAALSDAGLDEQSRQLTDKMKESNATFARLADKVTGYVNEGKADLARTEALMWAVPTSDELSGAAAAIRENERAFKERAESDNAGRVTLTKRMLLGSSAVAIALALAVGWALSRIIVRPIRRLSVAAERIAAGDLTDGDLAFRGRDELAGLAASFNGMKANLRELIRRAGDNAGQVADASGQLRANSEQIGGLSERVSAAIEQIAASMDEQTRLAAAGEEELRRLAASAEEMEASAVKVNDRSASAQAAAEAGKSSVGQALAQMESIRSGMETLASLIERLDAKSNEIDNTVDIISIIARQTNILALNASIEAARAGVQGRGFAVVAEEVRKLAAGTANAAAEISAMLHGIRSDMGDVSEAMEAGRRDVSGGMAIVQGTEGAFLRIDEAVRDVAVQAGAMAGRSSEMAARSRAASRELATVLASAGQIAVGAQEASAGTQEQYAAMEEMIASTVQLSREAERLKEGIAGFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKC3</accession>
    <name>A0A398CKC3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2164 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02602">
        <property type="protein sequence ID" value="RIE02602"/>
        <property type="gene ID" value="D3H35_18130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018680">
        <property type="entry name" value="DUF2164"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09932">
        <property type="entry name" value="DUF2164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="85" mass="9876" checksum="1F7A840769386B88" modified="2018-12-05" version="1">MIVVKLPKEQKKALVSSIVQYFEEERSETIGELAAEQMLDFMLRELSPYVYNKAIEDARELVLRKSSEVEDELYSLQRPIANRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKC4</accession>
    <name>A0A398CKC4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PBP1A family penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_21800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01649">
        <property type="protein sequence ID" value="RIE01649"/>
        <property type="gene ID" value="D3H35_21800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transgly" evidence="8">
        <location>
            <begin position="38"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="7">
        <location>
            <begin position="302"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="657" mass="71656" checksum="753FD466DA9729EB" modified="2018-12-05" version="1">MTLFGLLTAAGGGYVLLRYGALPAGSVPQPTQLLGADGTVIAQLEGGVNRRSVRLADISPWLIKATLAVEDRRFYEHRGVDVRGLARAAWTDVRHLSKRQGASTLTQQLARNLYLSHERTWKRKLKEAWYAARLEQTYTKDEILELYLNQIYYGHGAYGAEAASRLYFGKSAKELTPAESALLAGIPKGPSYYSPHRHPKESRQRRQTVLQVMKDTGVISSATADEASHTAVSVRPLPEEPEGTAPYFADYVLKIAESKLGIDERLLHDGGLVIRTTLDADMQRKAEEAIRDGLPPKSELQGALIAIDPRNGYIKAMVGGRSYRGNQYNRVFASTRQPGSSFKPIVYAAALERRIVTPATRFRSEPTIFYYDNDRKIYQPSNYADRYFRTEIGMRQAIAASDNIFAVNTIMQTGAESVIAMARRLGIGSPLKAVPSLALGTFPISPFEMASAFSAFANGGFKYTPLAVLSIRDSKGNTLYEAHPRGEQVISPALAFVTTQLLESVFQKGGTAYRVSRLLARPVAGKTGTTDSDAWTVGYTPELATAVWLGYDKGRAITSGEAHRAAPIFANFTESALSGSASPGLFTMPEGVVTALIDPVTGLLATDGCPNPVLETFLSGTEPSASCYVHGSAKEKTGGTASQKSGAWWKKLRHWWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKC8</accession>
    <name>A0A398CKC8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_17085</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03163">
        <property type="protein sequence ID" value="RIE03163"/>
        <property type="gene ID" value="D3H35_17085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="63"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="289" mass="32798" checksum="6FF5AC8C2312A5F2" modified="2018-12-05" version="1">MNLTGWLFILPAILVVVLLLIYPIMSSIYFSFTSKHLLRASFNWVWFDNFKFVLTNPDFYIAFGNSIKWTSLSIAGQLLMGFALALALNKIPKYSGLFRTLLIIPWAFPAIVIAFSWKWIFNDVYGFVPNLLTTIGITDHNVNFFADPSFVFGAALFVNIWFGTPLFMVNILSALKTIPMEQYEAAVMDGATAWQSFWSITIRHIRGVIGLLLILRTIWIFNNFDLLYLITGGGPSNLTTTLPIFAYKAGWGMKQLGVASAITVILLVFLLAICLLLFRLLNKWEREDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKF4</accession>
    <name>A0A398CKF4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coproheme decarboxylase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Coproheme III oxidative decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hydrogen peroxide-dependent heme synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_19275</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ChdC family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02780">
        <property type="protein sequence ID" value="RIE02780"/>
        <property type="gene ID" value="D3H35_19275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01442">
        <property type="entry name" value="Coproheme_decarbox_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031332">
        <property type="entry name" value="CHDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010644">
        <property type="entry name" value="ChdC/CLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36843">
        <property type="entry name" value="PTHR36843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06778">
        <property type="entry name" value="Chlor_dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="248" mass="28497" checksum="736B904B12A9D0EB" modified="2018-12-05" version="1">MSEAAQTLEGWYVLHDFREIDWTAWNDATPEARNEALAGLNSFVAKCEEVEASKEGSLALYSIVGQKADFVFMHLRETLEELNELETAFNKSAFARFTRKTYSYVSVVELSNYMGQPGVDPMQVPEIAARLKPILPKSNHICFYPMNKKRDLSDNWYMLPMEDRKTMMRSHGMIGRGYAGKVKQIISGSVGFDDWEWGVTLFADDALQFKKLVYEMRFDEVSARFGEFGPFYVGNRKSRESLNDWLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKI4</accession>
    <name>A0A398CKI4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_12925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01709">
        <property type="protein sequence ID" value="RIE01709"/>
        <property type="gene ID" value="D3H35_12925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041612">
        <property type="entry name" value="YfiR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17922">
        <property type="entry name" value="TetR_C_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="198" mass="21733" checksum="AA28C8585B4738FC" modified="2018-12-05" version="1">MLKGENTRKHIIAKSAELFNQRGYAGSSLSDITELTGIKKGGIYRYFASKDEIAVEAYQYAGSIVGSKINEALDREPTAMGKLLVYLRVYENVVEAPPFVGGCPLLNLATESDDGHPVLREQARQGLARTLDAMKEIISEGVQSGEFKADLNIDALATFTLSVMEGGIMLSKLEGDNRHVRMNIENLTAYLKGMCLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKK9</accession>
    <name>A0A398CKK9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_18655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02682">
        <property type="protein sequence ID" value="RIE02682"/>
        <property type="gene ID" value="D3H35_18655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="5">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="217" mass="24089" checksum="4BB319E8F99C286F" modified="2018-12-05" version="1">MREENPVRVLLVDDHEMVRIGLAAVLGTEEGIEVVGEAGNGLDGLRLAQDYRPDVVLMDLVMDGMDGIETTRRLLEVMPDCRVIVLTSFLDDEKMYPVIEAGAFSYLLKTSRASEIADAIRAAARGQSVLESQVASKMMNRFRRPAQTASQPHEELTDREMEVLKLIAEGKSNQEIADDLFIGIKTVKYHLTNLFGKLGVEDRTQAAIYAHRNGLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKL5</accession>
    <name>A0A398CKL5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_19620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02840">
        <property type="protein sequence ID" value="RIE02840"/>
        <property type="gene ID" value="D3H35_19620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="37"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="238"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="387"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE02840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="492" mass="53419" checksum="EB073C4F4936FA52" modified="2018-12-05" version="1">MSSLTNTFEELGLNAKLTEKLASAGIKEPSAVQCATVPSMLEGRDGVIVSPTGTGKTLAYLLPILHRIDPALRETQALVLAPTQELAMQIVREAEAYGGPLGIKAVGLIGGASLARQLERMKGRPALVVGTPGRVKDVASSRKLNLNTIRTVVVDETDRIYSLGGRSELEHILRGCSRDRQTVFVSATRSASMKEAESRWLNNAWLAEGHASESAANGLPETIEHWYFLGDRRDKVDLVRKLLRHLKLKPILLFLNDTDRIGELLSKLKYEGISASALYGDVSGRERGEALRRFRVGQTKILIATDVAARGLDVPGLPVVIQFEPALDADHYVHRAGRTGRMGKKGISITFISTQERFIVDKLGKQLGIEFQPKALYEGRVVAPEQATKIRPPRAEQAGSEPSGKPERSDSAGQSRKPDAAGIDALSARSPKTARIAHTDKPAKSAKPAQTAKPAKAAKSERHRDSKNKGAPRWLKEKRSTGTQEGPGNENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKQ9</accession>
    <name>A0A398CKQ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_13385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01789">
        <property type="protein sequence ID" value="RIE01789"/>
        <property type="gene ID" value="D3H35_13385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="372" mass="42553" checksum="446E49D0C3805E07" modified="2018-12-05" version="1">MNKPADDWEKELRQGPFRRRTFTEAKMNAIERQIAAGTGRSAARARIAAWTVSLASIVLLVIAVSAVLVNVRGDDPVQAKPPQPTPTSVPTAAPDDSGSYVKLKADWGLLRKVLPFDTEKVRSITVERTGQLQVITIPEDRVFLILKDLYYTNLDKALAYEQPSGKNGAVLRLHTPDRSYAIPYDLDTNTYKFNDKLYYADDKVAFLMYFLLKPESDLAKVERLTAQADREMEQSRAIVDESFSYDIKRFEINDLDYNGWSRKAYLNKAFPTINYYSYNVVDNSVANFVVDLRYNERNAIVYSLNSIFFLNDYTSTSDHIKVGLTKKQVLEKLGKPNLQLNSKWSYKIDDYLRFHIYYENDRVAGISLTMPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKU2</accession>
    <name>A0A398CKU2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase DnaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_19290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02782">
        <property type="protein sequence ID" value="RIE02782"/>
        <property type="gene ID" value="D3H35_19290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006343">
        <property type="entry name" value="DnaD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07261">
        <property type="entry name" value="DnaB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaB_2" evidence="2">
        <location>
            <begin position="352"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="500" mass="57058" checksum="5ECC53D85881AE41" modified="2018-12-05" version="1">MRVSNILEFTENHRYTVYRDFALSGLDRAVLTRLYQPMVGAFAIGLYLLLYHQMGDDRTGYAAPDSQRKLFLGLDLEMNPSGRKALIDNASKLEAVGLMQAYRHHDPVSEETLYEYALNRPLSIGEFFASMHLTLLLRDKIGKPAVMELRGELMEDAPAGLARFVNREEVTVPFYELFQIGGGTVDRELEQALAESAPTRERTISSAKPEKIRQSDILLRFPRGSANRVHVERLHLSPESMGQINYLAYKFDLDVPEVCRLLDEDGLFHNDGTLQWDEMNRRANLVYRQDRKRDEERERFMARGEGRSDAARDEPADPLDPSYLLNVPERFLAEVSQDRYNEMLRREPYTRMLEKYFPGSVPDSFIRIFEKIDLNYKLPEPVINVLIHYVLGMKHAQRLTGAFIDSVASNMLAKGIDTFRRAVAYVREQDKLNASLERKKRGETEGSGQAAGSSGGSSRGRTTRRKPDMPVVADRGPTQEVSAEEREKMRELARKLKGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKV4</accession>
    <name>A0A398CKV4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">tatA</name>
        <name evidence="9" type="ORF">D3H35_20685</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms a complex with TatC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03015">
        <property type="protein sequence ID" value="RIE03015"/>
        <property type="gene ID" value="D3H35_20685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="63" mass="6837" checksum="F3930E23E1FC645F" modified="2018-12-05" version="1">MPLNLGWTGILLLALIALLFFGPSKLPQLGRAVGSTLREFRSGTKELIQSDDPAAQPKSESRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL08</accession>
    <name>A0A398CL08_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA translocase FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_11700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03343">
        <property type="protein sequence ID" value="RIE03343"/>
        <property type="gene ID" value="D3H35_11700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="7">
        <location>
            <begin position="559"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="381"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="576"/>
            <end position="583"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="896" mass="97293" checksum="0E871F4EE23C9FB7" modified="2018-12-05" version="1">MAKRKKKKASFASSLKFEIYGILLITISVFAFAGEAAVGRSISKLFGYLLGNHYYMLALAGAWIGLYAMIKRGWPKGWTSRRSGFLLVALAFSLWSAMALLDSTLGTLEALTPSSIVSQTMAQLKEQLWSAEPATDVPIMKKSLGGGLVGALQYSIFYWMFGYYGAKFVLVVEFAIAILLVTGRSYVEMGQAVRMFLRRIFPLIYAKLSSGRRLLSAKAVPVRTKAKPKLAVQGAQAPIPDDDGLDEPPMQTSSRKTPLFFQLFHGKPEREAELPPSDDWEDEDTPVSFPSKANGRKKAEEQSSVLETPFNDVEIKEGTPSDELHSGPRFTDFAENTATAPWLSGENDDLKPIYADMTRPPIEPLTMAETVGEQLALDLETGTGPEGMAEPAETDSPAPAAEASSPVASTITPKPVRPAPKPYKLPPMNLLDKPAGNGKSGSANDYIDTARKLEATLESFGVRAKVLDVARGPAVTRYELQPDVGVKVSRIVSLTDDIALALAAKDIRMEAPIPGKSAIGIEVPNNEVSVVTLREVLETQAFQEAQGRLTIAFGRDISGQPIVGNLARMPHLLVAGATGSGKSVCINGIITSLLYKAKPDEVKFLMIDPKMVELNVYNGIPHLLAPVVTDPKRASLALKKIVVEMEKRYEKFSKSGTRNIEGYNALMLSGDNKDGVLPYIVVIVDELADLMMVAAGDVEDAICRLAQMARAAGIHLIIATQRPSVDVITGVIKANIPSRIAFGVSSQVDSRTILDMVGAEKLLGRGDMLFLPMGASKPIRVQGAFLSDGEVESVVGYARGQAEAEYNEELVPEVEESDESDGNEFVDELFDQAVQIILEAKQASVSLLQRRMRVGYTRAARLIDSMEAKGIVGPYEGSKPREVLMTMEQYQQRIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLN6</accession>
    <name>A0A398CLN6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01768">
        <property type="protein sequence ID" value="RIE01768"/>
        <property type="gene ID" value="D3H35_13270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="259" mass="28197" checksum="FA1E75ABDA58539D" modified="2018-12-05" version="1">MKTVLITGASSGIGKAFAELFARENYRVVLASRSEEKLNGIAQQLREKFGAITSAIPADLAQNGGPDLLYERLKEQDIEIDVLVNNAGIGSFGPLHEQDIRSELEMLQLNVQSLSHLMMLFLPDMVARGSGRILNVGSTTSFYACPLSANYSASKAFVLSLTEAVANELQGTGVSVTALCPGATGTDFFRSARMDGQKVADPKALMSPSEVAEIGYKALMNEKTFVVPGFQNWLLTQAPRFFPRKFVTRITRSVLEQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLY2</accession>
    <name>A0A398CLY2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diaminobutyrate--2-oxoglutarate transaminase</fullName>
            <ecNumber evidence="5">2.6.1.76</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Diaminobutyrate--2-oxoglutarate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-2,4-diaminobutyric acid transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_12835</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + L-2,4-diaminobutanoate = L-aspartate 4-semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11160"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58761"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="2.6.1.76"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amine and polyamine biosynthesis; ectoine biosynthesis; L-ectoine from L-aspartate 4-semialdehyde: step 1/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.76" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000038">
        <property type="protein sequence ID" value="RIE03252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03252">
        <property type="protein sequence ID" value="RIE03252"/>
        <property type="gene ID" value="D3H35_12835"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00067">
        <property type="reaction ID" value="UER00121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045303">
        <property type="term" value="F:diaminobutyrate-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019491">
        <property type="term" value="P:ectoine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004637">
        <property type="entry name" value="Dat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43552">
        <property type="entry name" value="PTHR43552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE03252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="127" mass="13705" checksum="44FC23698A75DDFA" modified="2018-12-05" version="1">MDGHVPGLRSEQLLREQELLEGNARSYPRGIPVAFQEGRGATLQDVDGNLYVDFFGGAGTLNVGHSHPDVLEASIAQQRKLNHSLDFPTEAKLRLMRNLKSVLPGTLAGSAKIQFGGPTAPMRSKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM52</accession>
    <name>A0A398CM52_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02299">
        <property type="protein sequence ID" value="RIE02299"/>
        <property type="gene ID" value="D3H35_16380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="176"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="291" mass="33046" checksum="D9289113BC4A8C4C" modified="2018-12-05" version="1">MTINYFTILLNHLEQMQIEVASAADSIVDEASLKARDVVYDCNRLLFVKEGRGKLYSQGEEVVLEPGVFCMQLSGMPHRLVLEPGSRMRLQWCHFRSSYGDREIFRTLQIPFHVCVENPEEVSRLFERIIEGLASDKVTARIRMKGVMLDLIGIFLELLPDGVDDPKGSQDLQKIDIVLKYIEDHLSDNITVEDLAGQVYLHPNYFIVFFKGLLGYSPIQYVNQRRMELAKALLVQPECNVSDVANRVGMQIYYFSRMFKVHTGLTPSRYRKQALAITASGPEPAAGKGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM57</accession>
    <name>A0A398CM57_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_11695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03342">
        <property type="protein sequence ID" value="RIE03342"/>
        <property type="gene ID" value="D3H35_11695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="158" mass="19048" checksum="61B6E038B02FE007" modified="2018-12-05" version="1">MLISGTTYHSFSNYSAQTLISGTRYHSFFLRLLRPDAHQWDDVPFFLRLLRQDAHQWDDVPFFLRLLRPDAHQWDDVPFFLRLLRPDAHQWDDVPFFLQLLRPDAHQWDEVPFFLRLLRQDAHQWDDVPFFLRLLTQTLISGTTYHSFSDYSAQTSHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM97</accession>
    <name>A0A398CM97_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">GAR transformylase</fullName>
            <shortName evidence="2">GART</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">purN</name>
        <name evidence="4" type="ORF">D3H35_16680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02349">
        <property type="protein sequence ID" value="RIE02349"/>
        <property type="gene ID" value="D3H35_16680"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="3">
        <location>
            <begin position="5"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="2">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="10-formyltetrahydrofolate binding" evidence="2">
        <location>
            <begin position="92"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="204" mass="22138" checksum="CD76BDF599297D97" modified="2018-12-05" version="1">MSAFKIAVMASGSGSNFQKLAEAARDGRIPAAIELLVCDKPSAKVVERAESLGIDTFAFNPKDYPSREAYEQEILNKLLELGIDLIVMAGYMRLITPVLVEPYYGKLINIHPSLLPSFPGLHAARQALAAGVKVTGVTVHYVDGGMDTGPIIAQRAVEVLGDDTEDTLYARIQAEEHVLLPDTVRLIAEGKVLLEDRKVTIHNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMA5</accession>
    <name>A0A398CMA5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_14285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01938">
        <property type="protein sequence ID" value="RIE01938"/>
        <property type="gene ID" value="D3H35_14285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="217"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="299" mass="32606" checksum="2BFC8B0D1B06D07C" modified="2018-12-05" version="1">MVAQRHTSALAAIWISLISNVLLTIIKLAAGVLFASPVLLADGVHNAGDIIATVAALTSSMVSKKPADDDHPYGHGKAEVVASAFVSVILVLAALWIGAESIRAMNEPAGQESWYPLIAALVSLLWKQALYVYTIRIGRATNSKSVLATAYDHLADVYASAAAVLGIGLGLAGEHYGWAWATYGDPIAGIIVSLLVLKLAYEIGRDSVDILMERNVPAEKLEHYEQLIRNIDDIKRIDRIRAREHGHYIMVDLRVGVPGEYSIQQGHDISREIKQHIMNADSDVVEVMIHLNPWYEGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMV8</accession>
    <name>A0A398CMV8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_29940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00254">
        <property type="protein sequence ID" value="RIE00254"/>
        <property type="gene ID" value="D3H35_29940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014258">
        <property type="entry name" value="CAP_domain_YkwD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02909">
        <property type="entry name" value="spore_YkwD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017366359" description="SCP domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="132"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="244" mass="25732" checksum="CF035BD0056A466B" modified="2018-12-05" version="1">MKNNKLKKSLAVGALTLAIAVPAGAGAASASVVQVKAYDWNQLATSANGFDWNAFIQQYIQVKAPSNATTGTGTGSGQTAQPSKPVTQPSKPAAQPSKPATTKPSTPSTSTGSNGSTAADSSASAYAQQVVTLVNQERAKAGLKPLQSNAKLTAMALDKAKDMYNKNYFDHTSPTYGSPFDMMKTYGISYRYAGENIAKGQRTPQEVMTAWMNSAGHKANILNANFTTIGVAYYNGEWVQEFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN40</accession>
    <name>A0A398CN40_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Non-ribosomal peptide synthetase module</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03895">
        <property type="protein sequence ID" value="RIE03895"/>
        <property type="gene ID" value="D3H35_07960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="196" mass="22614" checksum="EF6045F62281A548" modified="2018-12-05" version="1">MAHRVATEYVNANFNLTEAEMPKLLSLCETQLLRMQVFVLDNGNQEVVLDDDAGGETIRLTFERSNGRYRCVLSCRVVQPKLTNTLRKLVSFFKGDAVVNRIYHGFTMVYHYMAGAVVRIVECKGAEYRTVFEYSDTIGRLEHQFKLVFVEEEIRKIKNAVNELLDIRNQSVGSAQVREIDERLKYHSRLLFALEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNE2</accession>
    <name>A0A398CNE2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copper amine oxidase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_28920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00434">
        <property type="protein sequence ID" value="RIE00434"/>
        <property type="gene ID" value="D3H35_28920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017259056" evidence="1">
        <location>
            <begin position="28"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="2">
        <location>
            <begin position="399"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="493" mass="53979" checksum="75B119F1F6E24C18" modified="2018-12-05" version="1">MRKLLSMVLSLTLVFSSVFMLASVVSAESKFKITEDADIAARIQAFTSIKALFTDKTDLAAVKAAYVSQFQTETKRIDATIKADDPKIDENVVFVLDNAIKGSLNVNQAKQAVDKGLQWYFYFALRDLISNKVRPALAKEDYATAKTEFGKVVQIYEGVIQSTVSKRDASYGLDMVGILKGTIEQLLKDIDDKNVNDFNVHRQVLDKTIIKTYALATFTYATNIPTKPAADQPAAVTEGYFLFLPVYTYLRGGSVEDANYVLNAFASGDASKVDTAKIKAALQRTMIGKVSEYVTNAYVKLAAGDLQGARGYAMEGNMFLSTQEAFMTKDEYAAASGFAQQFADAVDRSDLNAAKAASFQMLKYLAPKDGIQLTLGDKNYTVDGQTRTAASAPYINKKTYRTLVPVRLIADAINAEVSYDNTTKTVKIVKDGKTTELKVGSDTIVQDGKVNETVKLDQPVVLEKGSSFIPLRAVAELFGKGVFNDKQSIIILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNQ5</accession>
    <name>A0A398CNQ5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsC</name>
        <name evidence="12" type="ORF">D3H35_02270</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE04996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04996">
        <property type="protein sequence ID" value="RIE04996"/>
        <property type="gene ID" value="D3H35_02270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="11">
        <location>
            <begin position="38"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE04996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="220" mass="24257" checksum="574C040181D31D35" modified="2018-12-05" version="1">MGQKVNPVGLRIGIIRDWESKWYADKDFGTLLMEDVKIREFLKNKLKDAAVSKFEIERAANRVNVTIHTAKPGIVIGKGGAEVEVLRNQLAKLTGGKKVHINISEIKNPELDAILVAESIAQQLERRTSFRRAMKQAIQRSQRAGAKGIKTSVSGRLGGAEIARQEGYSEGTVPLHTLRADIDYGTAEAHTTYGRIGVKVWIYRGEILPAKKRAAEEGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNS5</accession>
    <name>A0A398CNS5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pstA</name>
        <name evidence="8" type="ORF">D3H35_20060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02909">
        <property type="protein sequence ID" value="RIE02909"/>
        <property type="gene ID" value="D3H35_20060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="62"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="295" mass="31817" checksum="DAA6614863526DED" modified="2018-12-05" version="1">MKAKTADRIAISVIVGIAVLIIAVLASLLGYLLIRGLSHVSWHFLTSAPENIKAGGGIGPQLFNSLFLLVLTMLITIPLGLGAGIYMSEYAKANRLTNFIRLIVEVLSSFPSIVVGLFGFLVFVNLFEMKYSLMAGALALTVFNLPLMVRITEQSLRGVPREQKEAGLALGLSKWKTISSIMLPVAFPTIVTGTILAAGRVFGEAAALLFTAGMSSPRLDFTNWNPFSQTSPLNPMRPAETLAVHIWKINSEGLAPDAPEIAAGASAVLILIVLLFNFGSRWLGRVIYRKFTATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNW6</accession>
    <name>A0A398CNW6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DeoR/GlpR transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_02745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05066">
        <property type="protein sequence ID" value="RIE05066"/>
        <property type="gene ID" value="D3H35_02745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="255" mass="28752" checksum="1876AD684765FB85" modified="2018-12-05" version="1">MLAHERHNKILHMLHQNQFVKANELMGLFGVSFETVRRDLEHLEKEGYLKRVHGGATLPANDYRVELPFTVRELKLIKEKRELAQTAARFVEEGQSLFLDVSTTNTEFAKVLSERFERLTVLTNSFPIANLLMSKKGFTIIFVGGTVRNSEQSVVGDIAEAFVSQFHADTFFMSISGISLKDGVTDYGIGEIQLKKKMLLRSKKVIVLADSSKFEVVSLSPVCSLKEIDKVVTDSNVAPDLVRSYKEHGIQIVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNZ7</accession>
    <name>A0A398CNZ7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Cysteine synthase</fullName>
            <ecNumber evidence="5 11">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cysK</name>
        <name evidence="13" type="ORF">D3H35_09110</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5 11"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04092">
        <property type="protein sequence ID" value="RIE04092"/>
        <property type="gene ID" value="D3H35_09110"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005859">
        <property type="entry name" value="CysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01139">
        <property type="entry name" value="cysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 9 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="12"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="9">
        <location>
            <begin position="180"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE04092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="306" mass="31956" checksum="A872C6AC3131E350" modified="2018-12-05" version="1">MRRLTASSVVDLIGGTPAVALGRLTGPEDAEVLVKLEKMNPSGSVKDRAAYGLITDAEQRGLIKPGSVIVEPTSGNTGIGLAMIAAARGYRLILVMPDNMTAERISLLRAYGAEVVLTPAAERMPGSIAKAREILGEIAGSYMPNQFENAANPDIHRITTAIEILEQTEGRLDAFVATAGTGGTVTGTGETLKAKLPGLYVAVVEPAGSPVLSGGQPGPHKLVGTSPGFVPAILNTSVYDEIVQVSDDDALETTRRLARLEGLLVGPSSGASVWAALQIARRLGPGKRVLCIAPDTGERYMSMDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP29</accession>
    <name>A0A398CP29_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Efflux RND transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01637">
        <property type="protein sequence ID" value="RIE01637"/>
        <property type="gene ID" value="D3H35_25190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="271" mass="28812" checksum="A9A71A67817476F7" modified="2018-12-05" version="1">MTLSYDRQITSREELENVQVPTVGGLKKLKDVADITQQNAWIQVNHDDGKMYAQISGTVKKSDEVSAVTKKIEDNINSLSLPSGVEVTIGGGQQMIAEGFVNLGIAMVVAIGLVFLVMSMTFGGLLTPLIILSSLLFIPVGALGALFVTGQSLSMSGMIGMLMLIGIVVTNAVVLLDRVEKNRKSAGMPITEAIVEASKTRLRPILMTAFATMLALVPLALSGSSTSLISGGLAITVIGGLFTSTLLTLIVVPVVYELAWRKRKTKEAETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP52</accession>
    <name>A0A398CP52_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF664 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05166">
        <property type="protein sequence ID" value="RIE05166"/>
        <property type="gene ID" value="D3H35_02010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="22"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="159" mass="18099" checksum="734F837ECA917E79" modified="2018-12-05" version="1">MSETLLRSFADYKATSEWIRSSVEGLTDEQLSWKPSPDKWSVKEVVAHLVDSSLVHSVRIRKIVAEPNPSFVLYDQDAWVSTAKSNEESIDRLLSALDSILAYNVLYYGRLSEADWNRIGLNEGKEVPLYELFESFVRHSRTHLAQIERTKAARIAAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP72</accession>
    <name>A0A398CP72_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_02165</name>
        <name evidence="2" type="ORF">D3H35_29050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00455">
        <property type="protein sequence ID" value="RIE00455"/>
        <property type="gene ID" value="D3H35_29050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05196">
        <property type="protein sequence ID" value="RIE05196"/>
        <property type="gene ID" value="D3H35_02165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="140" mass="14629" checksum="C460FD9490C96DBA" modified="2018-12-05" version="1">MAANAKSSSIRSQAGKWKGQPVRVVLHDGRHYVGWIRGIEQNQLVLSGVRDNRKSKSGRGKLASRSTRKAKVSALLSPSAGNAAAALPGAPASGSVAGGGFFGLNGLDDWMGFMQKALPMVRMGVDMVKTIMPLLGGLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPA8</accession>
    <name>A0A398CPA8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02548">
        <property type="protein sequence ID" value="RIE02548"/>
        <property type="gene ID" value="D3H35_17820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010221">
        <property type="entry name" value="VCBS_rpt"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01965">
        <property type="entry name" value="VCBS_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="93" mass="10220" checksum="6610D77F9AAE99B3" modified="2018-12-05" version="1">MNRVMTKTVPGIGTTTFLMDVTAGLSTGYYGETTTDPKGNVTAKVYDKTGRLYQVKDGSTVQSTYVYYADGSQNTVTMRTALRKSTSISRTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPB0</accession>
    <name>A0A398CPB0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 20" type="primary">cobS</name>
        <name evidence="20" type="ORF">D3H35_08565</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04000">
        <property type="protein sequence ID" value="RIE04000"/>
        <property type="gene ID" value="D3H35_08565"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00317">
        <property type="entry name" value="cobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RIE04000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="273" mass="28833" checksum="541EF7F7C2180E37" modified="2018-12-05" version="1">MRGFRLAVVEWLKAVVAAFQFLTRIPLPFALEYTDKLNRRSVVFYPLAGAVIGGIVLAAGLLLNDWFPAAISAILLAALWTMLSGALHLDGLMDTADGLLSHRSKERMLEIMKDSRVGAMGVIVCVFYLGLKTASLAFLIEEGSAMPLVLIATIPAWSRSFMVAAIAAWPYARPQGGIGSLYRSVRMKHAIASSLGAAFFSAVFLFAYGGWSGTEACAIILVSAAVACGLGAAMASAISRKLGGLTGDVYGALNECIELGLLTALVGYVHNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPB4</accession>
    <name>A0A398CPB4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminodeoxychorismate/anthranilate synthase component II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01331">
        <property type="protein sequence ID" value="RIE01331"/>
        <property type="gene ID" value="D3H35_23440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="193" mass="21375" checksum="DCB3374140A857C6" modified="2018-12-05" version="1">MILVIDNYDSFTYNLVQYLGELGEEIIVRRNDEIDLDGIAKLAPDHILISPGPCTPNEAGVSLGLIERFKGEIPILGVCLGHQSIGQAFGGDVVRADQLMHGKTSEISNDGRTIFEGLPSPFTATRYHSLVVKRDTLPDCLEISAQTDDGQIMGLRHKEYVVEGVQFHPESIMTDYGLRILRNFLSYKEGVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPC0</accession>
    <name>A0A398CPC0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03159">
        <property type="protein sequence ID" value="RIE03159"/>
        <property type="gene ID" value="D3H35_16870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000831">
        <property type="entry name" value="Trp_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038116">
        <property type="entry name" value="TrpR-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013368">
        <property type="entry name" value="YecD_YerC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40080">
        <property type="entry name" value="PTHR40080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01371">
        <property type="entry name" value="Trp_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012508">
        <property type="entry name" value="YerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02531">
        <property type="entry name" value="yecD_yerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="106" mass="12012" checksum="C477941BE66AE056" modified="2018-12-05" version="1">MQLKKLNDKSIDQLFEAILTLKSVEECYVFFDDLCTVNEMQSLSQRLEVARMLGKGNTYNQIESETGASTATISRVKRCLNYGNDGYKLTLERLGRFGNETAETQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPD6</accession>
    <name>A0A398CPD6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04385">
        <property type="protein sequence ID" value="RIE04385"/>
        <property type="gene ID" value="D3H35_07295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="93" mass="10434" checksum="3911930F9094CFA5" modified="2018-12-05" version="1">MVEDIADIQQAVKVYKALGEPTRLKIAMLLTEERNLCCSDIAGKLESVAGSTLSHHLKQLTECGLLNLRKDGTYIYYSVNRTLAEKYAPYLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPE7</accession>
    <name>A0A398CPE7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01361">
        <property type="protein sequence ID" value="RIE01361"/>
        <property type="gene ID" value="D3H35_23605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="116" mass="12772" checksum="6A77607A81535180" modified="2018-12-05" version="1">MEERLMMGKMKNMKSMKSMKSMKKLMSGRPVMMRLERMALAMLEFWVGLFAGGAWFYSLASHIVRSGRRLLPSGSAGVHVGQAPDGGLPMRRIPVVLRAQPFTAIRKVAGLPAGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPJ7</accession>
    <name>A0A398CPJ7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DeoRC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000046">
        <property type="protein sequence ID" value="RIE00864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00864">
        <property type="protein sequence ID" value="RIE00864"/>
        <property type="gene ID" value="D3H35_26065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DeoRC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="50" mass="5687" checksum="D4B8E7D86DEC49E9" modified="2018-12-05" version="1">MLEAAKQVALVCDHTKFGNTALAKVCRLDELEHIITMKAFLLRCVKRWNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPL1</accession>
    <name>A0A398CPL1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000043">
        <property type="protein sequence ID" value="RIE00884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00884">
        <property type="protein sequence ID" value="RIE00884"/>
        <property type="gene ID" value="D3H35_25855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="137" mass="15059" checksum="9C82F0B73532F83C" modified="2018-12-05" version="1">MEKHVRQVVAELLDAGYEPDSQLAFYFEPDAAHTEADWEERAHLPLLHLFGKPSKLAGVSLKELGTSFFERSKLRLLPTAEYENGWRITPLNGSFKSADPDAASVDHSGGIVPKEGGTAVVEYEFEGKRAKASVTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ10</accession>
    <name>A0A398CQ10_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01917">
        <property type="protein sequence ID" value="RIE01917"/>
        <property type="gene ID" value="D3H35_14150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="69" mass="7623" checksum="DF4D7B7D02EDAA00" modified="2018-12-05" version="1">MAINLTAPTAQKSAREFADEYGFSFPVLWTKDGSVAESATDPPIPSTFFIDKDAYIVDGVLWLVRQPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQB8</accession>
    <name>A0A398CQB8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_20410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02968">
        <property type="protein sequence ID" value="RIE02968"/>
        <property type="gene ID" value="D3H35_20410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="2"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="401" mass="43374" checksum="D2B9D324644E9232" modified="2018-12-05" version="1">MIANHAFSAPFLRLYALALLFFSANSILNVMIPIRIESLGASNSDIGFIMGAYMFTCMFFRPWAGKLIDKHGPVIVLRILLVVNGLALVLYPFSGLEGYFAARVMQGVCTAFFSMALQIGIIDALPEEQRSQGLSLYSLFTYMPTIIGPLIAIGIWDWGGMSGFTVVMITMALTTGVFGFRVPMPSIVRKREESSEQRTGLRGALSQIASHRPLVICSALMLIASVVFGAVTAFIPLYARQISYGHAGLYLMLQAFIIVVARFALRKRIPSDGHWHSRYVGAICSFGAVGALLLSLSQAFGPLVFYAAAVLIGIAQAMLYPTLTTYLTFVLPGASRNLFIGLFIATADLGVSMGGMAMGPIADIFSYSTMYAATAGLAAIAVCIALLNRRMKSRLQQAECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQL0</accession>
    <name>A0A398CQL0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Argininosuccinate lyase</fullName>
            <shortName evidence="7">ASAL</shortName>
            <ecNumber evidence="3 7">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">argH</name>
        <name evidence="10" type="ORF">D3H35_15215</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3 7"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02107">
        <property type="protein sequence ID" value="RIE02107"/>
        <property type="gene ID" value="D3H35_15215"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="8">
        <location>
            <begin position="7"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="9">
        <location>
            <begin position="364"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE02107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="471" mass="52942" checksum="2585CD465D5237B7" modified="2018-12-05" version="1">MSKLWGGRFTKKTDQLVEEYTASITFDKELAEEDIQGSLAHVTMLGHCGILPAEDVEKIKDGLLKVRQRILRGEHEFLVADEDIHMSVEKALIEEIGPVGGKLHTGRSRNDQVATDMHLYLRKRVVEFVELLHKLQTALIGQAKANLDTILPGYTHLQRAQPILFAHHLMAYVSMFGRDIERLQDSYKRIDILPLGAGALAGTTFAIDRLYTAKQLNFGRVYENSLDAVSDRDFIVEFLSGAALVMTHLSRLSEELILWSSTEFQFVELDDAFCTGSSIMPQKKNPDVPELVRGKTGRVYGNLIGLLTVLKSLPLAYNKDMQEDKEGMFDTVKTLQGALQLFAPMIETMKVRTDKMRRAVDQDFSNATDIADFLAAKGLPFRQAHEVIGKTVLYCIQQNKFLLDLKLDEFKQFSALFDDTIYQVLQPESVVNARNVYGGTATAQVSAAIERADAELSRTSEWIAEYEAKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQM9</accession>
    <name>A0A398CQM9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04802">
        <property type="protein sequence ID" value="RIE04802"/>
        <property type="gene ID" value="D3H35_04860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005163">
        <property type="entry name" value="YiiM-like_3-alpha_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03475">
        <property type="entry name" value="3-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="37"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="230" mass="24721" checksum="701240D0E4F3105B" modified="2018-12-05" version="1">MSEQVCSLAIPLLSVNVGPARPMLYKGKEARSGIGKLPVDGSAELGLVGIDGDEQADLVNHGGEDKAVCVYSHDHYAHWESVLGRTLGFGAFGENFTTNGLLEPETHIGDVFRVGTAVVQVSQPRQPCWKLSMKWGLDELPALVTQTGATGFYFRVLQAGSVKAGDTLTLVSSYSAAITVAEANRVMHTDKNDIEGIQRLLGVDALSDSWVKQLRSRLERLESSSPGLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR17</accession>
    <name>A0A398CR17_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01871">
        <property type="protein sequence ID" value="RIE01871"/>
        <property type="gene ID" value="D3H35_13885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="216" mass="24743" checksum="413468F80519555F" modified="2018-12-05" version="1">MWQEDAIGNRTQFQYDAWSRTDRVTYPDTTFSTTAYNDIQKKVTSTDAVGNESITTSDIVGRTVKQEENKPGGLVTTLAENVYDYAGNVRESKDAKQQSTFYGYNFLGQLTSVTNAKQETTHYSYNMLGQQIRTTFPDQTFIVKKYDGLGRLIKRQDGNSKKATYAYDTNNNMVSQRIGTTRHLHSSTTTGIPRRRRSPPTRRFRTRMTWQASVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR48</accession>
    <name>A0A398CR48_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CO_deh_flav_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03268">
        <property type="protein sequence ID" value="RIE03268"/>
        <property type="gene ID" value="D3H35_11250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CO_deh_flav_C" evidence="1">
        <location>
            <begin position="16"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="83" mass="8830" checksum="18B63CC2BF2AA850" modified="2018-12-05" version="1">MRKSESRGWSSMLAQRLALAEKAVIGAKPGREAAEAMFAAVAAEYAPAPDPFASKEYRIRTVANLLAAEAWKLGRKAPPSEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR62</accession>
    <name>A0A398CR62_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03749">
        <property type="protein sequence ID" value="RIE03749"/>
        <property type="gene ID" value="D3H35_09330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="182" mass="21479" checksum="BE66567A451B825B" modified="2018-12-05" version="1">MMVFEDYIFLIECKGIEYSAYIATENSMKSDNSSKKISTGFDQLCSTAQMIKEGIFNQLIGDQQHKKIISAVITYKQLYLANSEWYYVNNIEPNMKSEQIDFKKCFQFKPQILSVHELELLLKYSQEKSENYFEIFNNRLENANYFLMGDWYRYLEIENTTIPFLKEAFLSFTDEALSKLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR73</accession>
    <name>A0A398CR73_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_02740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05065">
        <property type="protein sequence ID" value="RIE05065"/>
        <property type="gene ID" value="D3H35_02740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044159">
        <property type="entry name" value="IQM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250">
        <property type="entry name" value="PTHR31250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="565"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="574"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="621" mass="69322" checksum="19E052B1D792F544" modified="2018-12-05" version="1">MVGNQATQELLLNSARGTEQELPKPQFSTDAYSSNGYTPFKDDVPENYNYESDNMDGNTTTSLPKTISRGYTPFKHDVPEDYNYESESDSGQLFNIAGSAEPSAPQSQPESDKGGEAASQPLKTISKGYTPFKHDVPEDYATTPPKTISMGYTPFKQDVPEDYNYESESDIEIESDSKKESDSEIDSESGQLSKVSGAAEPSASGSNLPRISDKGFYMESNKEAKFDKKLLHQGAISGVDLDSTTFYANESQRASYSRSFDSTGKMVNKTDSKAVNTIGADRSATKGAKADRHIFTMDGQGEFHSTDAVKENRDRSKQIRNQRKQDLKGLQSDPENQEKLRNMELPAMERFHHSSFNAGGDIAGAGELQVRDGQVELVSDASGHYKPGSRQMIQTVQQLEKNKVPIEQLGVEFIGKPEFEYETDLKTGEHRVDEATGKKVHRLDAEGKKVKKLDQYGLQSVSKNMQASAMELLGYADHSPDAAEERMRDMHGKKNAMLEELLGKVKPVEPINYNYRDDVQSNHANLMRELRSKRAKIAPISGIQEEKYFGANKREEIIKKTEEVESGGYTSNDVKYRQDEDIYNDDKYDGDKYGYDSANDIGEKPIDRGYTDMDFTSDESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRQ1</accession>
    <name>A0A398CRQ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_01550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05233">
        <property type="protein sequence ID" value="RIE05233"/>
        <property type="gene ID" value="D3H35_01550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="81" mass="9161" checksum="770BFD7864EBE4F2" modified="2018-12-05" version="1">MQSAESKVNYSFILAQSKPYLLSPRETQIVYLLMQGQSCTQIAICLDISSNTVRTLVKRVYLKMNVSSKTAMIIKILESNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRY1</accession>
    <name>A0A398CRY1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_15290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02121">
        <property type="protein sequence ID" value="RIE02121"/>
        <property type="gene ID" value="D3H35_15290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03408">
        <property type="entry name" value="SPFH_like_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033880">
        <property type="entry name" value="SPFH_YdjI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13421">
        <property type="entry name" value="Band_7_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Band_7_1" evidence="6">
        <location>
            <begin position="25"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="DZANK-type" evidence="5">
        <location>
            <begin position="330"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="282"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="381" mass="40586" checksum="7249EBAC9C565AC2" modified="2018-12-05" version="1">MGLFSFIKGQFIEVIEWLDDRGVLVYRFPAYDNAIKMGAKLIVRESQAAIFVNEGQIADVFGPGTYTLSTQNMPVLTALRSWKYAFNSPFKADVYFVNTTNFTDLKWGTTNPVIMRDPEFGMIRLRGFGVYSLKVKDPAAFLKELFGTKQDFTTDSIAGFFKSVIVSGLSDLLGETKIPVADLASSYDELGQQAIDRLQSRFEAFGLALTGITIENLSLPPEVEQMIDRKSSMNIAGNLDNYMKYQAAEAIREAANNPEGGAAGTGAGLGAGMALGQMFGQMMNKPSEPASPPQAPASPDRSTTASSASAAASAPSSPTDPASSAATVPCAQCSHALLPAQKFCPECGTPRPEKRFCSECGQEASAAAKFCSGCGSKVNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS06</accession>
    <name>A0A398CS06_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_hydro_42 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_00825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05362">
        <property type="protein sequence ID" value="RIE05362"/>
        <property type="gene ID" value="D3H35_00825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017359635" description="Glyco_hydro_42 domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42" evidence="2">
        <location>
            <begin position="704"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="985" mass="108969" checksum="63E046619DF91E3A" modified="2018-12-05" version="1">MIVRKKAALLLFYGLLAIAAPSHTQGNSPGYELEVDELLDWKRVYEHSGTLILQTNPADSRDSSRVASVGASGGYIVYRAKSSLRSFAVYAYGTADRAFERLRFSISADGKTYRSVTPDLHEDGGDRGDPPAAVYESRGFPSGTKYLKIAFTGGEAGSGTTPAIGKAVLNGPGTAGASKTSGPVLYGSMIMLNRASEESDSVVYYTTDGSDPRTSPTRKRYGSPIPIVSYTTLKTTEAALSGADQETGGKVSTYTYVPYPLTPQPPGLSDPLDDFGKTAVRSNLYLAQNDSVYFDNDGSRAARATTSGGMLLYRTDYDMTSFAARSFYFTGQPFEKLRFYASPDGQRYEEIVADGYPSGYPESNWQPYSYESSSLPTGTRFLKIELRGTAKAWTPQLSELAINRTTASVTLASSRSGNVVRAEMSSATSGARIYYRLNKNEDYVPYTGPIRLQGYNQLETYAVKDGLLPSPLRSYSVNASSDVQVDRFGQMETAKFAGKVTGEAQLAADAKADADYYGSLTPPRDRDKYGGLAGSAVKYGWTATGFYGIRQMGGRPVMTTPEGNLYFSLAVNGVTAQETYSLIKGRETKFEHVPPYAGEYKPAYLGTDNFSFFVANKYLKTGRFSTESDIYAEAIGRLQKWGFNAIGAYSPEKYGEEGRFPYYRMLPLEGMSWARLDGLSIFDIYAPNAEAKLDQAFAQSVAPHKDDPMLVGYFIGNEFDFHRFYTDVPKLKASSAAIKGKLVETLKGKYVTVEAFNAAWKTSFKSFDEMKDSALTLKASPAWRDMDAFFAAYLDDFFGTVSRLYRKYDPNHLLLGDRWITTTFHNETVRRMLAEAEGKYVDVISLNYYTYKLEPDLLQEVFVKSGGKPILMSEFGYGTSEQGLEPLLKNSAANQFQRGMRYRNYVEGVAVLPYTVGANVFNYVDQAGLGRYWQGQWGEHYNSGLVNVADRPYKDYLAAAKATNDVIYQVMLGERPKFYYDFSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS95</accession>
    <name>A0A398CS95_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_09200</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04109">
        <property type="protein sequence ID" value="RIE04109"/>
        <property type="gene ID" value="D3H35_09200"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="338"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="155"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="274"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE04109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="456" mass="50399" checksum="16BBC14D329D612D" modified="2018-12-05" version="1">MNVVCIGSGYVGTVTGTAFAALGHRTTVIDIDADKVELINSGNSPIFEPGLDSLLPQLVSRELLSASTMFGEIGFADVVFIAVGTPSQADGTVDLTYVKSAARKIGEHLNREQLTVIVDKSTVPVGTSDLVASIIEEASGLRANENFAVVSNPEFLREGYALEDVLFPDRIVIGTEHPGARIVMRELYRNLLERTNYRELSRKVAFKMNLNAPKAVYFETDTKSAEMIKYVSNAFLAVKISYINEVARLCETLGANVLDVAKGMGLDSRIGEKFLQVSSGWSGSCFPKDTAELLETSRKYGSDLLLVEAAVDSNWRMHTNCVDKIKRQLKTLNGKNIGILGLTFKPNTDDARHTQSSYIIDKLIALGANVAVHDPKGMEMFRKINGHLPVRYCQKAEEVAERADAVVLMTHWEEYAALDWAHVRSRMKNPYVLDTRNFLIDHRLSELGFRYEGIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSI7</accession>
    <name>A0A398CSI7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_10455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03708">
        <property type="protein sequence ID" value="RIE03708"/>
        <property type="gene ID" value="D3H35_10455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017279124" evidence="2">
        <location>
            <begin position="26"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="338" mass="36653" checksum="69A912CBFF1B214F" modified="2018-12-05" version="1">MKTSKKTKALLFVIAAALVLGGCGARKEESPANTSSAESPAGAPTETSSASPSSSEPAGQTILEAFKEKAQAGQAAPDELFGELKDALGKSDTSTADELIRAMETYYDANLETTSKKFEEENIQKSLAELQFPVTEEQIKAIPDESVKKLAEDAIDGGYKLETAEGFVFPIVDYAKLQEIDDGASPSMQAYLALQATESNEATAKDAGLVITWEQLADRALAAEAFIRQYPDSPERVKVEDRFANYLNMYLTGLNNTPIFDYETFKALPEVKAQYKKTAEAHPDTVTGKLAKELLDVLAKTNDKVFDKSKDGSQQDVPEVKAFRDGLETEARNALPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTU8</accession>
    <name>A0A398CTU8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04138">
        <property type="protein sequence ID" value="RIE04138"/>
        <property type="gene ID" value="D3H35_08870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018679">
        <property type="entry name" value="DUF2161"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09929">
        <property type="entry name" value="DUF2161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="295" mass="32040" checksum="E42B4E353D8042F7" modified="2018-12-05" version="1">MAVERETELYPPVKAFFAKRGYEVKAEVRGCDLVAVRADEPTPTIVEMKKTFTLPLLLQGADRQRTGAFVWLAVERNRSKRGAHNQRFQELSAICRRLGLGFLTITFYKTKEPVAEVWCEPAGSGSVNAATRIRNGSSLATAETSAAYSSAAAAGGGRRRKGTAKLLQEFESRSGDYNVGGSNRSKLVTAYREKALQCMLAIRCHGPSAPRHVRSWTGCPNAALILRDNYYGWFQRVKKGVYGLSESGHAALAEYADIASVWAARFAWASEWKSAASDTTAADSASAVSGGESLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU46</accession>
    <name>A0A398CU46_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Paeninodin family lasso peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_06320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04228">
        <property type="protein sequence ID" value="RIE04228"/>
        <property type="gene ID" value="D3H35_06320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="53" mass="6030" checksum="F732966334EFDFC5" modified="2018-12-05" version="1">MKKMWTAPVIETLDVSMTMAGHGAHYVDWSYVGGKHLEINDDPKWKNYPVPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU84</accession>
    <name>A0A398CU84_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="7 8">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murF</name>
        <name evidence="12" type="ORF">D3H35_06475</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="7 8"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04258">
        <property type="protein sequence ID" value="RIE04258"/>
        <property type="gene ID" value="D3H35_06475"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="9">
        <location>
            <begin position="27"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="11">
        <location>
            <begin position="111"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="10">
        <location>
            <begin position="323"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="113"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE04258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="468" mass="48747" checksum="0EA9E149000AF31D" modified="2018-12-05" version="1">MMQAKLRDVAAWSGGFAGDAAGDTLLTGVSTDTRTIKPGQLFVPLVGERFDGHDYLNAAIAAGAAAALWQRSRPVPADPGVPLILVNDTLDALQTLASSYLETLGARVVSVTGSNGKTTTKDLVSSVLAVRYNVHKTEGNFNNHIGLPLTILRASPDTEVLVLEKGMSGFGEIAKLCSIAQPDVAIVTNIGESHLLQLGTRNGIARAKLEIAAGLKSGGVLVMNGDEPLLAEELAGISMPEGASVLTFGAGEGNDWRATDIEVTTEGAAFNAVKDGVAAEYRIPVPGRHNAVNALAAVAAGRLFGLSAADIREGLASAKLTGMRIERSTAKNGAVILNDAYNASPTSVRAAIDLVAGLDGYSRKWIVLGDMLELGGDEAAYHAEIGRYVTAGKAYALWAYGPLSAHTIEHAGLPSQGEEATARHYTDKERLASELLSAVGPHDLVLVKASRGMKLEQIVTALQKGAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUR0</accession>
    <name>A0A398CUR0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsQ</name>
        <name evidence="6" type="ORF">D3H35_02285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE04999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04999">
        <property type="protein sequence ID" value="RIE04999"/>
        <property type="gene ID" value="D3H35_02285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="88" mass="10344" checksum="96BF2D61CC7A056E" modified="2018-12-05" version="1">MSERNNNRKVQIGKVVSDKMDKTIVVAVETYKKHSLYHKRIKYTKKFKAHDENNDAKIGDTVRIMETRPLSKDKTWRLVEITEKAVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUT8</accession>
    <name>A0A398CUT8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02774">
        <property type="protein sequence ID" value="RIE02774"/>
        <property type="gene ID" value="D3H35_19240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017345667" evidence="1">
        <location>
            <begin position="27"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="159" mass="18128" checksum="CC85C6D036B8B860" modified="2018-12-05" version="1">MGKMGRILLLVLLCLGLSVPVVSANAAPPPSQKAKLLFDVEESWLENYWQYVTANGRTQQLEFDVIGPKYEHWMVSVDGNTFRLRDKFKVNPTIYTKKLSYRSPINYFDDVVKTVVLNADGYFQDVNTNDVSATIRTLRTSESCKFIIQAEVRVAGWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVD2</accession>
    <name>A0A398CVD2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_01690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05259">
        <property type="protein sequence ID" value="RIE05259"/>
        <property type="gene ID" value="D3H35_01690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1220"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="1258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1310" mass="137701" checksum="549512923B999BD8" modified="2018-12-05" version="1">MNDKTSNGAIAVVGVSALFPGSTDNGGFWNDIMAGKDLMTDIPETHWLIPDYYDPTPMTPDKTYAKRGSFLSPVPFDPKEFSMPPSNIPATDTSQLLGLMVAKNVLEDAAQGPFSSVDKDRISVILGTASASELTVELGSRIQRPVWVKALRESGLPEDQVQEICDRIASQYVPWKESSFPGLLGNVVAGRIANHFNLGGTNCIVDAACASSLTSISMGAMELLAGKSDLVIAGGVDTLNDIFMFMCFSQTPALSPTGDCRPFSDQADGTMLGEGLCMFALRRLEDAERDGDRIYAVLKGFGTSSDGKSKSVYAPVSTGQAKALRRAYEMAGYSPATVELMEAHGTGTKAGDAAEFAGLASVFDNEAREDKMWCALGSVKSQIGHTKGTAGAAGMFKAIMALRHKALPPTIKVVRPNPSLDIANSPFYLNTAARPWIRGSSHPRRASVSAFGFGGSNFHVTLEEYVGPGKKAWKLRTMPSELLLFSANAPAPVLAQCEELLAGLTDDEGLLAYQARKTQTDFDPKLPAKLAFVVANLGELRLKLEKAIAELRSHPERGIDDGSGMYYAYGANPGKVAMLFPGQGSQYVGMGAELALAFDEARAVWDCAADLQTNDRCTMQEAVFPRPVFTKEERDGQRSRLQATEWAQPTIGAMSLSLLRVLRTAGVRSDLFAGHSFGELSALCAAGMLAEADMLRAARKRGELMAAASEAASGSGAMSAVFAPLERIRGLIAESGLRVTAANHNSPSQSVVSGETEEIRGLEEKLSAAGIRYSRLPVSTAFHSPLVAASVPAFRAYLTECPVGEGGLTVLSNADGQPFPSSPDGVRNRLAEQIAQPVLFAETVEELYARGVRTFIEVGPGAVLSGLVEQCLEGRDVLVVPTDRKGQHGAHSLWHALGRLAVAGVELDLKRFWADYKPEDDPRSRKKPGFTISISGVNVGRPYPPEGGAAALPQPNAASVPDFAAPAFETQGKTTPSVTKPDGAQPEAAWPEPGIAAGGADFAANAVFAAGADPAEQPFFASSTSMPLYYEYQEEPMSNYYQATNQSVLLSAIAELQRQTVEAHAAYQSAMANSHIAFLRTAEVSLAGLNALAAGGFGAGAALPAAPALYTPQLAAPLTATPHTPVPASVVERLPAAPVLPPAPIFMAPAPALAAPPVYAAPNPAPAAFVPAAPVVPAAPPVAAAAFVQPVAAVTAQPLAAEQPVSPSAAPNIAGAASDAGAGDVRSVMLEVVAEKTGYPVEMLDFDTELEAGLGIDSIKRVEILSAVQDRLPELPDVQPGELAALNTLGEIVDYMNRALGKGGESAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW50</accession>
    <name>A0A398CW50_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000038">
        <property type="protein sequence ID" value="RIE03244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03244">
        <property type="protein sequence ID" value="RIE03244"/>
        <property type="gene ID" value="D3H35_12780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="405" mass="44653" checksum="88CDDE6CC81BB5D9" modified="2018-12-05" version="1">MAYNPEEVEFGWYIPTYGDGRYIGVKPERESTLAYLTEVAQTAERAGFTFALIPTGGSCLDAWVVGSALVNATTTFKPLVAMRPGLISPVLAARMASTLDTLSGGRLLINVVTGSTASDLKVMGDPLAEEHDRRYDRTREFLEIVKSLWINGKAGQDEGYFTVQNPYQGIEPVRFHGDYYDIDAGISYPSSVQSPHPPLYFGGSSPAGKQVAAEQANVYLMWAEPVDWIKEQIADLERIGAQLKADKGIDRTLRYGIRAQILVRDTEEEAWQDAWNIISKTEEGAIEQSNRRFGKTDATNQKRQNELRDLSKKDNYILGPNLWAGLSTVRSGGSLLIVGTPDQVSDRILEYVDAGVSSFILSGFPHLEEADIAGRKLLPLVKSKLAARDAERIGEIETKTTEEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW86</accession>
    <name>A0A398CW86_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagellar assembly protein FliH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_11375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03284">
        <property type="protein sequence ID" value="RIE03284"/>
        <property type="gene ID" value="D3H35_11375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018035">
        <property type="entry name" value="Flagellar_FliH/T3SS_HrpE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02108">
        <property type="entry name" value="FliH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FliH" evidence="2">
        <location>
            <begin position="151"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="280" mass="31021" checksum="364246E058BF7687" modified="2018-12-05" version="1">MSNLIKSGRVISLEDLKRLENARKFELPPQNISSNPDIGEGESSIDVETQSMRDRILQDAEQAARQIVEASQETARQLVADARSEADDWWRERRAEDSQVAEEARQSGYDQGYKEGIGQAERDLAKQWDARLNEANAIVRQAYITKDNTIAEAERFLVELSCAITEKIILAKVAEAPEMAVNMFARALARRKEQGVITLCVSPSQFGFVQAAKEELMLVIDSQAELQIVPDASIKDGGCIVRSAFGSIDARIDTQLDAIREELLRVAAQAREEESGDGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWE7</accession>
    <name>A0A398CWE7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000028">
        <property type="protein sequence ID" value="RIE04147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04147">
        <property type="protein sequence ID" value="RIE04147"/>
        <property type="gene ID" value="D3H35_07820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="444" mass="49504" checksum="26E1E0E3B6200E53" modified="2018-12-05" version="1">MSMPRNWEEELSEMPTGAGGFSMRTIRKVKERIAMQEKKKYRYRQAAAAIVCTVLLGAGYLLRDDLADWMRKAPAAKPVISDDEEVRLSVQYYDTGSLLQRYSTFIIRHPSVRLEAVSPPQGEAYTAEGYVSWAKKSSADIFQVPLAYVDDMSREGLIKPLDAWIKRDSYDIESLYKPVVQAIREAGAGQLYGLAPSFETYALYYNKTLFNAANIPLPKDGMTWEEVWNLAAQFGESPKGNDIAGLSFGRYSPAASLSLLGQSMGLRLTSADGKLPTIDTPGWRKALEPLARGWREGWISKQQPKKREGDILMKDLYMEDPFLTGKSAMSFASSIYMNDIRSAEKLIPFQDKWGAVTQPTATGNPNDSRLFGVSYIYAINSSSKDADAAWELLKAMVSKNQALRDKRNNYSSLSAIPLTDNSEPEDVFFESSNPSVIGMADSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWS6</accession>
    <name>A0A398CWS6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">truA</name>
        <name evidence="9" type="ORF">D3H35_02390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05018">
        <property type="protein sequence ID" value="RIE05018"/>
        <property type="gene ID" value="D3H35_02390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="7"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="145"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE05018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="275" mass="30638" checksum="DDB8127B5C1D9C1C" modified="2018-12-05" version="1">MRNIAMIVSYDGTNYSGFQSQPGCLTIQGELEKALFVLTGQHIRVNGSGRTDAGVHAKGQVINFRTDCGIPVERFALAINARLPGDIVVQSVYEAPQEFHARHDPKSKTYRYSILCSRFADVFRRKYELHHPTPLDFAAMAKGLEHLIGEHDFSSFASPKSTKSSHVRTIYECRLEVETLLPFEDTDAWRYPGKQRGRIHLYVKGNGFLYNMVRIIAATVILIGEGKLSPSDMARILVAKDRSQAAPTAAPHALSLWALDYGEVFGDKPETPDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXQ5</accession>
    <name>A0A398CXQ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_00045</name>
        <name evidence="8" type="ORF">D3H35_01195</name>
        <name evidence="7" type="ORF">D3H35_08950</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000011">
        <property type="protein sequence ID" value="RIE05318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000001">
        <property type="protein sequence ID" value="RIE05486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04065">
        <property type="protein sequence ID" value="RIE04065"/>
        <property type="gene ID" value="D3H35_08950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05318">
        <property type="protein sequence ID" value="RIE05318"/>
        <property type="gene ID" value="D3H35_01195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05486">
        <property type="protein sequence ID" value="RIE05486"/>
        <property type="gene ID" value="D3H35_00045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="10"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="5">
        <location>
            <begin position="154"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE05318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE05486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="224" mass="24939" checksum="76A805659AB7A62B" modified="2018-12-05" version="1">MTNETGVSWKVMIVDDHEMVRMGLRTYLMLDSRFEVIGEAASGIDALEKLKNGGFDGRMPQLVLMDLMMPHMDGVETTKALLDSFPELRIIILTSFLEDDKVVEAIEAGAVSYVLKTVSADELLYAMQGAIKNMPVMSGDVSQALTRGLRKRSVQNDGEGLTEREREVLLLIAEGKANKEIGDELHISIKTVKTHVSNLLMKCEVDDRTQLAIYAHRKGWVKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXZ3</accession>
    <name>A0A398CXZ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000006">
        <property type="protein sequence ID" value="RIE05408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05408">
        <property type="protein sequence ID" value="RIE05408"/>
        <property type="gene ID" value="D3H35_00535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="81" mass="9110" checksum="26492EAA3A536259" modified="2018-12-05" version="1">MTKLLHHALRKNARSGQTISMLHPFSVPFYRKYGMSADGDEKAVHDRDEAFSSSADVPDGCHCAETFGTAERRVRTIRCKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY88</accession>
    <name>A0A398CY88_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03964">
        <property type="protein sequence ID" value="RIE03964"/>
        <property type="gene ID" value="D3H35_08365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="148" mass="16282" checksum="58E585299F0FF5EB" modified="2018-12-05" version="1">MKQTTSATDGSFLFQIEIMVSGETNGEALEKLLHVLNEGGFEDFRIKSGIRLGKKIDEALAASANNKNPVDLPAPAAASPSGLGLDIQQYIKTNKLLRLNINKGRGIRLSIPCRVIGFDADSQQITVYHVDEKQVYSFKLNEIDDFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYK2</accession>
    <name>A0A398CYK2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_05135</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04907">
        <property type="protein sequence ID" value="RIE04907"/>
        <property type="gene ID" value="D3H35_05135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="310" mass="34755" checksum="398918FD4CE18AF4" modified="2018-12-05" version="1">MIEIRALSKQFGTFHALKAIDLTIRKGTVFGFVGPNGAGKSTTMSILATLLAPTSGIAKVDGIDVTQNPEAVRKKIGYMPDFFGVYDRFKATEYLHFYGASYGIPKAERNKLIPQLLQLVNLTDKKDAYVDTLSRGMKQRLCLARCLVHDPDLLILDEPASGLDPRARIEMREILKELKEMGKTIIISSHILPELAEMVDEIGVIEHGRMVAHGNVQEIQSRLRVKRILLIRTAGRDAEAEEYMANRPHVNRILRDDKGIHVHFGGQDEEQSELLHDLIGHGFRLISFSEAQTNLEDVFLEITRGNEGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ00</accession>
    <name>A0A398CZ00_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ligand-binding protein SH3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_02750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EamA transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05067">
        <property type="protein sequence ID" value="RIE05067"/>
        <property type="gene ID" value="D3H35_02750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="160"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="293" mass="32339" checksum="B18C74FDACA69ADD" modified="2018-12-05" version="1">MCENVCFRSGILSVLLVLASGIAHAIWNMLTKRSDNKQIFLLLILIPSTLLLFPVFANELLHQRISGQGYFLLLMSLMVQAVYGFLLSKSLANGDMSQVYPMMRGISAFLLPLIGSIFLRETLSLWGWIGLLFIAAGFCLTSGIGSKRHRQAVSSKVIWYTVGVGLCTMSYVLIDKINLRHFSPITLLEVSNMGFILGLVSFIKKDEIRAVVQGKNKIRLLLLGSVLSPGSYLLFLLAMDLSPLTYIAPLREFGTVFGAFAGIYLLKERKEVIRLVSAGVIFAGILLIGIWGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZM3</accession>
    <name>A0A398CZM3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_07225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04374">
        <property type="protein sequence ID" value="RIE04374"/>
        <property type="gene ID" value="D3H35_07225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="72"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="145" mass="15572" checksum="AF9940A384B299B9" modified="2018-12-05" version="1">MRKIADIMSSDCVTVTPQDNIYEAAVLMRDHDIGFVPVVEGNKLLGVITDRDLVIRGYAGKHSGSTSVMDVLTEGARTISPNVSVDEAVSIMASEQIRRLPVVENGELKGVVSIGDMAVREIFVNEAGQALSGISEHEHGQSITH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D024</accession>
    <name>A0A398D024_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative NAD(P)H nitroreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_00110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nitroreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000002">
        <property type="protein sequence ID" value="RIE05467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05467">
        <property type="protein sequence ID" value="RIE05467"/>
        <property type="gene ID" value="D3H35_00110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02135">
        <property type="entry name" value="YdjA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026021">
        <property type="entry name" value="YdjA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000232">
        <property type="entry name" value="YdjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 3" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="136"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="189" mass="20767" checksum="DA3029056A054EF3" modified="2018-12-05" version="1">MNVEEAIRTRRSIGKVKDEPVPRELLERMLEAAVWAPNHHQTEPWKFVVMTGEGRKTLGERTQKSRPAFPKPFGAGEAELHKREEAKANRAPVVIAVVCSPSEAPRVSRAEEFAAANSAVQNLLLSAHASGLGAVWRSGDPMYHPAMKSAFGLQPQEELVGLVYVGYPDLQPPEGKRIPAASKTIWIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0H3</accession>
    <name>A0A398D0H3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04664">
        <property type="protein sequence ID" value="RIE04664"/>
        <property type="gene ID" value="D3H35_04020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="202" mass="22817" checksum="76F848ACE6EABAF4" modified="2018-12-05" version="1">MSATTRIGWIRHGITAWNQLGKIQGATDIPLSEEGGAQARLLAARLAEEKNRWDGVVCSPLSRAKSTGETIAERLGIPIRFDSRLKERAFGEAEGTTEPERLARWGDDWRRLVPDQETDEQVLERGLSFLDEFVRDHEGEAWLVVTHGSFLGRMLQSMCDDLTDGRLNNVSLTVVERRGEKWIPLLHNCTAHLNERIESQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CAW8</accession>
    <name>A0A398CAW8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000061">
        <property type="protein sequence ID" value="RIE00286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00286">
        <property type="protein sequence ID" value="RIE00286"/>
        <property type="gene ID" value="D3H35_29375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="258"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1489" mass="157814" checksum="68FD306B14C8B0D9" modified="2018-12-05" version="1">MVNEPPAGNDYYNIILGTESRELKPLLLPDGRSPGASSDSIDLSADGKTIAFNSHKSFVPEDTGSSDFDVYWYDWHDPNATKLVWLSGLIENRKYSGTVKVDSSGRYAVFNITLQNNSYMSYVFDSAAPAGTVPEPLMTVPASSPMTLDYITSHSISGDGRYVLFSSQGKNIVPGDTDNVTNLFVRDRLEQKTAMVSLPYDPSIKIMVYSSDGMLSRDGTRFAFRSSMMNMVSGSERSKMGLYVQRIAVTEPSASWPAGSSLTASDIGKTSVKLTWTPAERAAGGYKIFGGPAVIDVPAGATEAVVTGLASDTAYTFTVQAASASGVWTTDGPGAPVHTQAGEGLADLTLTVQGSQVKLVWGDPPAGSGTVSALRILRKLGTGDWQTLATVADAAARSYTDLSAAPGKTYSYVIRGVDGNGQPFPYSVEKTVDIGGFAISSFNYTMPFYFRQHAGQGDKVKLTLLASAGAAAKAELAYLDVNGVNRTLQSALVEAAETGVYKGELAVPEAAAKLLSLKGYIEEDGQTAEAEALREPILVGGTVDVELTGALDLPNDSLLTIYSKSVHAYQSATLKGMRSVTLKGLPAADDYTLTLSGAGGIDLFDDVPVPPVRIVAGGHQLVSAEPLLPARVNVAIYNPSGTAPDVHVIVTDEEGHPLASGITALNGNLSFPAFKKMVGKKAIIRAAPKDPKFASLEQTVTLASGLNRLDLRLTLKTDATLTGTVTDKDGKPVKDATVQVWYQGNYYKAQSDTTGRYTLGVPAGNVYAQAIVAGAFASSAITVATVSGQTKTVDIRYTRQIPSIFEVKLYTETENGSWIGPYELDWREMVHFHITSSASLLGSSNPLLVDAAAGQSVKICANGIEGGYGKACTEVTIGDKLKYEAVLRLSYLNTKAVGQLAETPASVYLYRLDNGANKTYVESRTAYTGSLVLKLPGAGTYELKVNAPGGKTLTRTFIAQEGETVNLGGLSAGESGAFAGRPGNSVLLGTSNPAPGTMLRVSASYSNYLSTSLSGGVLVLDVPADAELVPGSVVWNGQPVTPALADGRYIVSLGTIGSRAIGSLQYLVRVADEPISESLDISPRIRYQSSGKPVEEEIGFARAAVARLTMTAPRRTAYRRFHVTGTAPAGSKAAVYAGDRVVGTAETAPNGRWSTSVEIDGEGHTAVWQLRAEASLGEQRWSSAWSSVQYDENTAEPIEFTLRQPDGRTIRLDPREGEIRFPYVFAPGLPFIATLKFNRPELARDVAFYIGETRVPASLKDGVFQAVINAVSPGAIGIDYSTRESGESIGGTPPPAAEIREQLPPAFRDARQEDLYISPREGGDRKQSMAYTGLLTGAKSDARVRVSAALERTTYAPNANDLALEKETGVPLYGFRMNQSFSDGVLRIELTGYLPADQFSAGLDAQKALALMSAGAQTHSYAELLSGVSGAAKKPAPVKALNAAIGVVAARVGLAFESAAGQNTWKAIDAAYSIYDGREAAIRSRIWNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBT8</accession>
    <name>A0A398CBT8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_29845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00240">
        <property type="protein sequence ID" value="RIE00240"/>
        <property type="gene ID" value="D3H35_29845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="387" mass="42201" checksum="D0DF53AE3545CC97" modified="2018-12-05" version="1">MNSWHIAMNLVRRTLGQKRGIWVYLVIPVATLTILIALIGGGGPEPARIAYVNEDQGSLGGHLVRELERVQGYSLKEIGSEAELKKNQIDQKAAASFVIPANFTEQMLNGQVPSIEAYELNISEASVTLKLRIDSAARQTAQTVRTVIASGVQGEAAVREAVERVAAQAEKHQVQPKVTDFDLYVDPNMSVIIGFTLMFLMGLINTTVSSVMEDRRLRTMARMFAAPVRAFEIAIGNALGSFLVGTLQVLLVLVFTRSIVGFDYHLPFLAHFLIMEFFVLACMGIASAVGGALRNSNAAGMLNGVIITPTCMLGGCFWPISFMPDWMQKIANFMPQKWVIEAIDRLAAGESLTDVWLPFGVLALFAVVLISFGSVILQPNKAEVNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CC32</accession>
    <name>A0A398CC32_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recN</name>
        <name evidence="7" type="ORF">D3H35_26330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RecN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00716">
        <property type="protein sequence ID" value="RIE00716"/>
        <property type="gene ID" value="D3H35_26330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="6">
        <location>
            <begin position="2"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="562" mass="63368" checksum="68EAB5ACA53AD6E9" modified="2018-12-05" version="1">MLRELSIRNLAVIENVSVSFHRGFHVLTGETGTGKSIVIDALALAAGGRGSADMIRHGEAKADIEAVFDLSAGHPVWEVLERLGIEADSEESLLVRRELISQGKSSARINGQNVTLSMLREVGEHLVNIHGQHEHQSLLRTDRHLEWLDQFSGEAIIPHKAAYKEKFRRYQEVSRERRELEDKSRQGMQMLDLYRFQLEEIEGAKLKIGEDESLAEERRKLTHAEKLSDAVSESYDLLYGSKGLAALSRALNRLQDIVKVDPAKLAPLVEQLQSAYYGVEDTAYQLRDYRDTIEFNPQRLSRIEERLDLLYGLKRKYGETVEDILAYERKIREEADRLENRDDRVRVLAEEEHALEQELVMQAEKLSAIRREASRTLAKQIEQELADLQMGRSVFEVKLVEGVLTSTGSDNAEFLLSTNPGEPPKPLGKIASGGEMSRVMLALKAIFARIDRIPVLVFDEVDTGVSGRAAQAIADKLSLLSRHCQVFAITHLPQVACMADHQFEIRKDVTEEGRTVTSVNELPAEDRVEELARMLGGVEVTEKTRHHAQEMLTLAKERKNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CC52</accession>
    <name>A0A398CC52_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage III sporulation protein AC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spoIIIAC</name>
        <name evidence="2" type="ORF">D3H35_26435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019007235.1">
        <property type="nucleotide sequence ID" value="NZ_QXJM01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00736">
        <property type="protein sequence ID" value="RIE00736"/>
        <property type="gene ID" value="D3H35_26435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009570">
        <property type="entry name" value="Spore_III_AC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025664">
        <property type="entry name" value="Spore_III_AC/AD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06686">
        <property type="entry name" value="SpoIIIAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02848">
        <property type="entry name" value="spore_III_AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="67" mass="7637" checksum="72EF0FF1276443DD" modified="2018-12-05" version="1">MNIDVSTIFQIAGIGIIVAMIHTVLKQMGKEDMAHWVTVIGFVVVLFMVVRLLNDLFQEIKTIFLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCT2</accession>
    <name>A0A398CCT2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 16">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="6 16">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">D3H35_27630</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="6 16"/>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00520">
        <property type="protein sequence ID" value="RIE00520"/>
        <property type="gene ID" value="D3H35_27630"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016204">
        <property type="entry name" value="HDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000098">
        <property type="entry name" value="Homoser_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 16" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11 15 16" id="KW-0521">NADP</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="18">
        <location>
            <begin position="350"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RIE00520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="428" mass="45972" checksum="9827C22CD2B8630F" modified="2018-12-05" version="1">MKQVNVGLLGLGTVGTGVVRIVEGHREDLQSQTGSPIHISKILVKDRAKTRSISVDSSKLTEDPWEIVRDPAIDVIVEVMGGVGETKQYILEALELGKHVVTANKDLMALHGQELLAKAREKGCDIYYEASVAGGIPIIRTLIEGFSSDRITKIMGIVNGTTNYILTKMSQEGAAYGDVLKEAQALGYAESDPTSDVEGLDAARKMTILSTLGFRANVALDDVDVKGISSVTQEDIQYAKQLGYEVKLLGIAERQDEYISVAVEPTLVKKSHPIASVNGVFNAVYVYGEAVGETMFYGPGAGELPTATSIVADLVAVVKNLKLGVNGKQAVTSYKEKKLKTDEQIASKYFLLLHVEDRAGVLAQIAQVFSDCDVSIESVMQPAPPNKAGAELIIISHNASKAAMSTVLKSFESLSAVREIKSVYRVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDA1</accession>
    <name>A0A398CDA1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_28705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00395">
        <property type="protein sequence ID" value="RIE00395"/>
        <property type="gene ID" value="D3H35_28705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="266"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="516" mass="57145" checksum="448A8891E2196229" modified="2018-12-05" version="1">MTHLSDTLLLHVEGLGKHYNGNRAIENINLRLPKGIVHALIGENGAGKSTLIKLLTGLVRPSAGTIVWKEKEVIFKSPQSAIQEGIVAVHQELTLVDTLTVCENIWLGREPRTRLGTIDFAAMERESKRLMQELDIHIPTGEKVKHLSIADKQLVELIKAIAHDPQLLILDEATSTLGEKEVDKIYQVVLKFKQQGKSVLFVSHRMKEIFQFCDTCSIFKDGMHVTDGLIGDLTSSRIIEYMTGRDISQTYPPKLKDMDPVNKERFNTGPILEVKGLFTRSGLQNVNLSLYPGEIVGIGGLQGHGQSELIQALFGLEQITEGSIAVNGRSVKLNKPLSAIREGIQLVPQDRKTEGLFVELDVAENLIPCSLDRISKGPVLNRRAKTQAVKAMIEKLSIKVASETQVVKLLSGGNQQKIALGKWLLKDAKVLMLIEPTRGIDIKTKMEISALLRKLASEGYGVIVSTNEMNELIGLSDRVLIMFEKQTVNELKDGDITEQNILNAAFGKRGMAYEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDJ0</accession>
    <name>A0A398CDJ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_28185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000054">
        <property type="protein sequence ID" value="RIE00495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00495">
        <property type="protein sequence ID" value="RIE00495"/>
        <property type="gene ID" value="D3H35_28185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="54" mass="5912" checksum="EF6F23A13BCEC1CC" modified="2018-12-05" version="1">MLTYGGPGTSSELVATYMYKQAFSSMYYGYGSAIAVFIAVECFLWSDSLCKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEB8</accession>
    <name>A0A398CEB8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">8-oxo-dGTP diphosphatase MutT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mutT</name>
        <name evidence="6" type="ORF">D3H35_29635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00202">
        <property type="protein sequence ID" value="RIE00202"/>
        <property type="gene ID" value="D3H35_29635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008413">
        <property type="term" value="F:8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003561">
        <property type="entry name" value="Mutator_MutT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00586">
        <property type="entry name" value="mutt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="8-oxo-dGTP binding" evidence="2">
        <location>
            <begin position="32"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>8-oxo-dGTP</name>
            <dbReference type="ChEBI" id="CHEBI:77896"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR603561-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR603561-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="137" mass="15340" checksum="54553A2068FD46FF" modified="2018-12-05" version="1">MIEVAAAIIENRQGYILIARRKKGKSQEGLWEFPGGKLEPGESPEACLKRELMEEMNIEIAAYELFGVNEHDYGAVQIKLIAYRAKYLGGEIRLADHDEYRWASHAELGEYLWAPADVPFVELLGNLSAEGSGQESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CET8</accession>
    <name>A0A398CET8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF885 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01233">
        <property type="protein sequence ID" value="RIE01233"/>
        <property type="gene ID" value="D3H35_22840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="192" mass="21534" checksum="3887DABD9C72931B" modified="2018-12-05" version="1">MDGYRDGRFFLPLDNAIPATLTHLFAVHEGVPGHHFQFSIQYNSPTIPLVRKITLIPGFVEGWAVYAEALCAENGLVDPIAIQNRLLDLYLGTVIDTGINELQWTREKANEYISSIIGTDSDALIDSVIAFPGLIPGYAVGYDQFQSLREKAEDELKDRFDIKAFHSVLLRNGNMPFSMLEQQVNQYIESAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF01</accession>
    <name>A0A398CF01_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycolate oxidase iron-sulfur subunit</fullName>
            <ecNumber evidence="4">1.1.99.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_28550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-lactate + A = AH2 + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:15089"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>A + glycolate = AH2 + glyoxylate</text>
            <dbReference type="Rhea" id="RHEA:21264"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29805"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="1.1.99.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 2 [4Fe-4S] clusters.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.14" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00462">
        <property type="protein sequence ID" value="RIE00462"/>
        <property type="gene ID" value="D3H35_28550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012257">
        <property type="entry name" value="Glc_ox_4Fe-4S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32479:SF17">
        <property type="entry name" value="PTHR32479:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000139">
        <property type="entry name" value="Glc_ox_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="439" mass="48380" checksum="17794B1830AD1B5B" modified="2018-12-05" version="1">MDSMRQTLKLKLDYDQLTNCMRCGFCLPACPTFKETGLEAESPRGRIALMKATVDGVMDPDVPFEEQMSHCLGCRACEPACPADVKYGQLIEQARDAIETHTRQHRGWVRGVRKLVFKGLFPHQNRMSLLGKGLRLYQKSGLQAVARKTGAVGVFSKQLSDMERILPEAGGQGVVQRFGTRVAAKGEKLGTVGMFRGCLMDVMFAETNRKTVEMLSEAGFEIVIPDTQNCCGALHAHSGEIDQARQLAMNNILAFQAAGVDYIVSNAGGCGAILVEYDHLLHDVPDWSEQAVWFAGRVKDVSTLLAENGRKLHFRKEEAGEAPVRITYQDSCHLKNVMKGGGAPRKLLSDLPGVELVEMQDAGSCCGSAGIYNITQPQMANQILDHKMQHANATQASYIVTSNPGCLLQMKLGIEKHADREHVQATHVIDFLYDRMVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF67</accession>
    <name>A0A398CF67_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tgt</name>
        <name evidence="6" type="ORF">D3H35_27700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00532">
        <property type="protein sequence ID" value="RIE00532"/>
        <property type="gene ID" value="D3H35_27700"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="5">
        <location>
            <begin position="15"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="4">
        <location>
            <begin position="248"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="4">
        <location>
            <begin position="272"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="377" mass="42155" checksum="BC057BF23541BA5C" modified="2018-12-05" version="1">MAVTYELIKTCAQTGARLGRVHTPHGIIDTPTFMPVGTQATVKGMSPEEVKELGAQIILSNTYHLFVRPGHELIREAGGLHKFMNWDRPILTDSGGFQVFSLAENRKITEEGVTFRSHLNGDKLFLSPEVATGVQNALGSDIIMAFDECPPYPAEYEYVKKSTERTSRWAERCLKAHARPSDQALFGIVQGGMHADLRRQSAADLTSLDFPGYAMGGLSVGEPKHLMYEMLEETVPFLPSNKPRYLMGVGSPDALVEGSMRGVDMFDCVLPTRIARNGTTMTSRGRLVVKNAKYASDFGPLDPDCSCYACRNYSRAYIRHLIKADEMFGLRLTTIHNLHFLVHLMQDVRQAIQEDRLRDFRDEFFENYGMAGNESGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFQ5</accession>
    <name>A0A398CFQ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Undecaprenyl/decaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_14780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02026">
        <property type="protein sequence ID" value="RIE02026"/>
        <property type="gene ID" value="D3H35_14780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="381" mass="41116" checksum="E29A1BC7D18A714B" modified="2018-12-05" version="1">MSTGWLVGIGIAGFLVALALAMILTPLVKKFAIRIGAIDVPNQRKVHTRIMPRMGGLAIFASFTVVILALLPFIPNNMMLSHNRNLIAAMLTGGTIIVLLGALDDRFELSAKLKLLVQIAAACVVVFGFDVKVNILNIPFGSAMQPLGEWLSIPLTIFWIVGVTNAINLIDGLDGLAAGVSGIAITSILVMGILTGNGTVILLSAVLLGSIAGFLHFNFHPAKIFMGDSGSLFLGFSLAMLSMLGFKQITVVSFVTPLLIIGVPLSDTFFAIIRRWVNKKPIFAPDKGHLHHCLQQLGFSHRTTVLLIYGIAAFFGACAVLQSYLTETGLGNWVTFIVICVMVFLLQIGAELIGIVDRSRRPVLDFLARMRMKTETNSRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFV2</accession>
    <name>A0A398CFV2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3892 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00782">
        <property type="protein sequence ID" value="RIE00782"/>
        <property type="gene ID" value="D3H35_26690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024997">
        <property type="entry name" value="DUF3892"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13031">
        <property type="entry name" value="DUF3892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="80" mass="8835" checksum="C048155649596E87" modified="2018-12-05" version="1">MELNSSGKEQVVAVRKNGDGDIVELKLSSGRAVDYKTAQQMVKAEQIAGLNVFRGRDGDEHLRSDPDGREDNNLDNMPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGH7</accession>
    <name>A0A398CGH7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_13720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01843">
        <property type="protein sequence ID" value="RIE01843"/>
        <property type="gene ID" value="D3H35_13720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="17"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="408" mass="43535" checksum="CA9A9CE04DF115DE" modified="2018-12-05" version="1">MTTSAATESTKNTALSILLGVSGAHLLNDAMQAVVPAVFPLFQQEMHLSFAQIGWVAFTLNITASILQPLIGTYTDRRPMPMLLPLGMLFTLFGMLGLALSPTLAYLLVSSALIGIGSSILHPEASRVAHLAAGRGKGFAQSVFQVGGNTGQAIAPLLAAYVIGPQGQLGFLWFILLAVAGIMLQYAIGKWYGQQARRTGAARRASSLASDKGFSRAFIAFVLGILILMLFSKFVYLASMTGYYSFYYMEKFHLPLERAQLCLFALQFAGMIGTFLGGPLADRFGRQKIIWFSILGTAPFSLLLPYAGPTGSVLLCLAIGLILMSGFSVIIVYAQEMLPGYVGTVAGLFFGLSFGMGGLGSVIMGAIMDSHGVSFMMKACAYLPLLGLFALLLPKDSVIMNGRRLPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGT1</accession>
    <name>A0A398CGT1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14370</name>
        <name evidence="2" type="ORF">D3H35_14410</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01953">
        <property type="protein sequence ID" value="RIE01953"/>
        <property type="gene ID" value="D3H35_14370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01960">
        <property type="protein sequence ID" value="RIE01960"/>
        <property type="gene ID" value="D3H35_14410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="141" mass="15126" checksum="BCC3685DCD55F78D" modified="2018-12-05" version="1">MNSEFVIAVHSLVLLAHHPEGMASSEEIAANVCTNPARVRKVMSCLRKNGIVDTREGSGGGYKLCKPPERLTLADVYRALAAGSLAPSWCSGNPEGDCVVSSNMGEVMDSVFCGADHQLELYFDGITIGQMLSRVRAKQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGW7</accession>
    <name>A0A398CGW7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01710">
        <property type="protein sequence ID" value="RIE01710"/>
        <property type="gene ID" value="D3H35_12930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="56"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="295" mass="33753" checksum="4B8B1F28793E3A3C" modified="2018-12-05" version="1">MFPYYPQIHQFPYSDNRFMPRGFYYSPYTDGGWLWPHDVQESDESCRPSPQQRLSFVLVHGSWADAHFWDGIAAELSREGHIVYAPEYAGHGNDQNKAVTHAMITKSVVDFITRLNLRDIILVGHSFGGSVIQKVAEQIPDRIKRLVFWDAFVLKDGESVADELPPQTRQGFEQLRAASNDDTIMLPFPLFRDLFVNTATLEVARQMYARVTPEPAKPLFEKLDLKAFYALPTPKSYVFFYQDNVFAQGEGFGWYPHMSSRLGLFRLIVGDGDHMTDSLTRPAMVAQKLYEAGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGY9</accession>
    <name>A0A398CGY9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YhfC family intramembrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01725">
        <property type="protein sequence ID" value="RIE01725"/>
        <property type="gene ID" value="D3H35_13020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011397">
        <property type="entry name" value="YhfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10086">
        <property type="entry name" value="YhfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="233" mass="24867" checksum="9FD8B3AC65989568" modified="2018-12-05" version="1">MKATVEHVQSIDEKFTQAARRSMISLPIYVLVPVLFGLGFWIAGYGIEWKAFGLGALGWFIALMLRGPLSLLVKSMPQEKAKNIIVASSGVLEESVRVILLALTSVAASWAISIGQGWAAVEVAFVMVNIVAIASLSKRTDEKAEQAKQLLAAQGNIQSSPVWGLLERVWASAFHIGCTLIVARYAWTVALLIPLHSSLNAVAVRLAVRSVAASSLFVAATGITALIAGMIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGZ1</accession>
    <name>A0A398CGZ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02013">
        <property type="protein sequence ID" value="RIE02013"/>
        <property type="gene ID" value="D3H35_14705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="158" mass="19039" checksum="CF15ABF8A64376A0" modified="2018-12-05" version="1">MEENLDPQFETAHTNWMEKQRKSARGERRRRLSLPKGGNYAELQFLARIWWPAFGQFDNLHPEYEVRDFKDGYRYLDFALLLGGLHICIEIDPYGTHKRDIDRWKYNDNLIRHDHLVLDDWRILRFSLDHIQRHPRLCQQLLQQAIGKWGMAPSTPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH35</accession>
    <name>A0A398CH35_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_13340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01780">
        <property type="protein sequence ID" value="RIE01780"/>
        <property type="gene ID" value="D3H35_13340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="361" mass="39906" checksum="FB0BF08C1BEC33C5" modified="2018-12-05" version="1">MGRFMRAFLNGGELTGQRILQNDAVADMTSLHASFNPALGGMGYGFYMNERSGMRILQHGGAIPGWHSILWIIPELNIGVFVAVNGEGEPGLPDELMNTFLNENVTWTTPAFALESGQSSNALSSAKYAGRYILNRHLSDSVFKIATLWQDIRLKVAAIDDGSLLVSGTDYSCICTNKGSGLWHNTLGTVAFASYENDDGFYLQLSGNPTADYRRMAWYEDEKLHLAVAAGFGLLFVLGTLAWIGFSLRFRKLWRSIPGIVCGIYVIFIAGILAELNTLDMGSATPASFYFILSLPIISALLIALELVRWVYEWRQRKIASNRSAVAIAFIRLGRGLLITAQIAFLIYLNYWNMLGWSGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHH3</accession>
    <name>A0A398CHH3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_28520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00368">
        <property type="protein sequence ID" value="RIE00368"/>
        <property type="gene ID" value="D3H35_28520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="669" mass="74477" checksum="BAB40A93855E695D" modified="2018-12-05" version="1">MRMAEIRFVSKDDCKEAAALADFVFRDKEQSSMAVAFPSIFSGSYESSIGVYEEDKLVAFAGLVPSVLQIGPSRVPIFSLGAVCTHPDFRGRGYAGAMQNEAFSHIEKSGGTMLLVSGELDIYLRNGCRRFGAMREYSLKPETAARIEHKSSNRKLIVREARESDWFMLNELDEANPVRYRRSMYELATLTRAEAIASIYKLKHRIYVAEEAGTAIAFAIVAVKAQWETGSQPRVIEWAGEAEAAALILACAVRENSLSELGLFVPWQEKALQSALEPASYEPTTNSGTVKIVNPMRLWERLQPYLFERNKELASRISLADANTGEEGAVELTVDGIAYSLHADELTTLLFDPEPQLPAELAGNSIVQALFPCLCHTHRVFISSEKERLRMIFDCHTHLFGPGHFGGPTLAAAKRAWGEHTEMLALPEQHEENIKDIDGAIVLAFDGPATGMNVPNEYVADYVSKKPGRLFGFASVDPNRDNAAGILEAAIKEYGLSGLKLGPIYQNFYPDSKEHYELYAKADELKLPILWHQGTSFVPEGYLDASRPAMLDPIARAFPNLKMIIAHMGHPWTDECIAVVRKNPAMFMDISALGTRPWQFYNAMVLAVEYGVTHKILFGSDYPFFTTAQTIERFRAINDLTEGTKLPRIPEQVIEDIIHRNTPDLLGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI71</accession>
    <name>A0A398CI71_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_25995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000045">
        <property type="protein sequence ID" value="RIE00869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00869">
        <property type="protein sequence ID" value="RIE00869"/>
        <property type="gene ID" value="D3H35_25995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="203" mass="23867" checksum="E15CC96E06E933A8" modified="2018-12-05" version="1">MQDKKRTILEAAIRCFSRKGFHATSIQEIAREIGMAKGSMYFYFNSKDELYLSVLEYYTDMLFRCMEELPEDRELSSRDKLRVLIERQFRFFREHLHFMRMLFLEPATGLNPQVQNLLMRTRARSAVWTLSHISAIYGNRAARYVTDAATMFEGMTGRYLEKLFFDDAELDEGRVSRFLINRIDHLMKGLLLTGEEPILPAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIC3</accession>
    <name>A0A398CIC3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase KduD</fullName>
            <ecNumber evidence="1">1.1.1.127</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kduD</name>
        <name evidence="1" type="ORF">D3H35_17515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.127" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02493">
        <property type="protein sequence ID" value="RIE02493"/>
        <property type="gene ID" value="D3H35_17515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047001">
        <property type="term" value="F:2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008678">
        <property type="term" value="F:2-deoxy-D-gluconate 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011286">
        <property type="entry name" value="2-deoxy-D-gluc_3_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01832">
        <property type="entry name" value="kduD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="265" mass="27921" checksum="F145DF3DE70D9A15" modified="2018-12-05" version="1">MRRFGATKGARSELKKLFDLTGRTAIVTGAGRGLGRAIAAGLAEAGADVALVTNRTPADEAKREIEALGRKAIVLQADVGDRAKLAGLVEETVVQLGRLDILVNNAGIIRRTPAAEHSYDDWQEVLDVNLNSVFVLSQTAGRVMIAQGSGKIINIASMLSFQGGINVPGYTASKHAVAGLTKALANEWASKGVQINAIAPGYMSTDNTEALRNDPARSKAILERIPAGRWGSDVDLVGPAVFLASSASDYMNGHVLCVDGGWMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIK0</accession>
    <name>A0A398CIK0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01892">
        <property type="protein sequence ID" value="RIE01892"/>
        <property type="gene ID" value="D3H35_14015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032720">
        <property type="entry name" value="Cys_rich_CWC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14375">
        <property type="entry name" value="Cys_rich_CWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="73" mass="7994" checksum="DA7F3E9F0854B0D9" modified="2018-12-05" version="1">MMNCPICGGSNFCAMEAGTASQGCWCFETKFPKELLDRVPEELRDKACICRSCAERAALEEGCPRPTTALTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIM1</accession>
    <name>A0A398CIM1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D3H35_26275</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00708">
        <property type="protein sequence ID" value="RIE00708"/>
        <property type="gene ID" value="D3H35_26275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="339"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="501"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="372"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RIE00708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="617" mass="69893" checksum="BA796B9D1CCF03AC" modified="2018-12-05" version="1">MRYNGTILHRGAFRLIARGWSRLSRLVSGRLRNKLILLFSAIAACIVILLSYLSYLQSAGLNRDNYIESNRKILKLVNQNLDGYLDRIDELSISPRKDAPFMDAIISKEYSSQAYIQNQLKTLFYSGEDIEEVSIYTPSAGQLYTMSRSFVNLRQEYTDRPAEQAWYSEALKSRRFRSIESGYGRVEVSERGYFLVFHRILINIADKKPLAAISITYNLKEVSRILQDISDKPGEFIGIFNESNDVFYVKGPPLNPENTESLLRLVPNDASDTGQKSLTIDGENYLAIYNVSPRNGWKLITLTPNRVLNEEASQARRINLLAGAGAVFVLVVFIVIAANAITGRLNRFSRQIGLLGEGNFDVQSKIEGSDEIAQLSRKYNQMVARINDLIAERYEMQLNERNARLIALEAQINPHFLYNSLQAISTEAIIGGMDTIQEMVDALASSLRYSIKEAETVRVREEISHIRNYALLQQARFGERLRLHIESDERSAEAWIPKMTLQILVENAIKHGLEQMTGDIDIRIVTEEAGGLLLIRVSDNGPGIAPDRLTHIRERLAVNQLEYREGIGLNNVNARIKLLFGPESRLEIDSKAGYGTEVTVTLPMREERPYVQSVDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIW2</accession>
    <name>A0A398CIW2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Recombinase XerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_16440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02310">
        <property type="protein sequence ID" value="RIE02310"/>
        <property type="gene ID" value="D3H35_16440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13495">
        <property type="entry name" value="Phage_int_SAM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="26"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="136"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="327" mass="36968" checksum="278871B1697D3F05" modified="2018-12-05" version="1">MEFEGDDPNKNDYDSPNAASYAEEELDDDRTVELFLSLLGRSPHTLNNYKRAIKQFREHIACKRLKDVTWRDLEEYKLGLIRGKASRSAKPLASASVAALIAPLKSLFKWGSDPNVALFPRNPTSSVKLPQVKVTSTHHFLTRKETGHLLDRLRQSGTRDFLIGLSLVTLGLRVSELAAIRWIDFRSDAAETSIWLNVVRGKGGKERNVKVPRELWRWLSDYRALTNAAGPTCEPETRVFPISTRQIERIIKQAAAQCLAKSPTPHWLRHTNATLALLRGASLQQVQETLGHTHINTTQRYLHTVDQLKKTATDFVEETLLELLEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ27</accession>
    <name>A0A398CJ27_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_15240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02112">
        <property type="protein sequence ID" value="RIE02112"/>
        <property type="gene ID" value="D3H35_15240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007391">
        <property type="entry name" value="Vancomycin_resist_VanW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04294">
        <property type="entry name" value="VanW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51109">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="G5" evidence="2">
        <location>
            <begin position="112"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="214" mass="23945" checksum="743E1A4ACABE9F66" modified="2018-12-05" version="1">MFQYGDIVSKAEKEYGWKEAPVIVKGKLTPGIGGGICQVSSTLYNAILEAGLDVVERRNHSLVVHYLPPGLDATFADGYVNFRFRNSTGKQLLIRTVVEDKRLTVKLFGTMPDNVVYRTETEQIKVVAPKVTYVANSKLALGSSDTLQKGEPGYVVDTYRLKYVDGKLVERKKLNRSTYKAQAELVAVNPADPLLHPEGARLPRLHRLRRMKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ38</accession>
    <name>A0A398CJ38_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01239">
        <property type="protein sequence ID" value="RIE01239"/>
        <property type="gene ID" value="D3H35_22870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="459" mass="51638" checksum="B8EE8992B9D5FEB4" modified="2018-12-05" version="1">MKFNSAWTKGRAWTLATVLLGALFLPACQSVPKPEGPKKLKIAIPDDRAYSYRYQTFVDAKFPGWEISTVSMEDLKLFEHPLEAGQLLEDFLKREKPDLVYMYSYVYPAVEGSLLRDLGEYAARDKWSLDAFEPAVIDQLKNNDEGKLFGLSPGFRSTALFYNKTMFDRFGIERPHDRMTWSEVFASAARFMQDKRMEKGSYGFSEALMTTPVNYLTTLSTTEGMRFYDANTLKMTMQSEVWESIWNRVATAYRQGAIGAIEYKPKTIDGNIVYTKDDMEKINLFFQGKAAMTTGGDDLIQQLQSGHVPFEWGVVTGPVSERDGNAVGWFTVDDVFSIPVVSEHPEEAWEVIRFLHSEDVGKVIASTDQGLSSLKNFTEWKNDPLYKPFYGVHSWPGALNSWSNPVPPAFLGPFYELLAKQMNDTISGKTTAKQALETLQTKGQALMDSLPTEAAANAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJH7</accession>
    <name>A0A398CJH7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Dihydropteroate synthase</fullName>
            <shortName evidence="8">DHPS</shortName>
            <ecNumber evidence="4 8">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">folP</name>
        <name evidence="10" type="ORF">D3H35_23430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DHPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="4 8"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01329">
        <property type="protein sequence ID" value="RIE01329"/>
        <property type="gene ID" value="D3H35_23430"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="9">
        <location>
            <begin position="26"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE01329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="287" mass="31537" checksum="C24DB0BB42E306A1" modified="2018-12-05" version="1">MTIKPTFYERSYTFDDGLELELGRRTLIMGILNVTPDSFSDGGRYDAVERAVEQAKKMAEEGADIIDIGGESTRPGHTPVPLEEELRRIVPAIRAVREAVKLPISVDTYKAEAARQALEAGAHILNDIWGFRREPNMAYVAAEYGCPVILMHNREARDYTDFVPNVLADLRGCVARAHAGGVADDLIWLDPGFGFAKDYDEHIELMGRLDEVAALGYPVLLGTSRKRFIQNTLNVGAGDTVEGTGATVSLGISQGCQIVRVHDVKQMKRVAAMTDAICYRQAGRRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJL3</accession>
    <name>A0A398CJL3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ParM/StbA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02510">
        <property type="protein sequence ID" value="RIE02510"/>
        <property type="gene ID" value="D3H35_17625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10227">
        <property type="entry name" value="ParM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040607">
        <property type="entry name" value="ALP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042051">
        <property type="entry name" value="ParM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17989">
        <property type="entry name" value="ALP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ALP_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="365" mass="40945" checksum="529CED712E48AC5E" modified="2018-12-05" version="1">MIRLAGIDIGNDSVKVVVGGGLDPVIIPSIVSPGYERHVLQEEDSPLKALDVMVYSPKLKKKSQRFFVGLLASEDQDNAELEETDNKATSDQSLIVALTALAYASVTSVAQTLQPGQTIDEVEYVIGTGLPVRTYARFHQVFEERLVGEHEVTFLSTPKLRGRTVRVKIRRAIVSIEGAAALFNMATHDNLQVRDEELYHGVIGICEMGALTTDFPVVKRMSIDNQFSTGEQLGLASYLDSIIRDIEDQYGYRFPSRTKLIQRIRRGEFIIQRVGEGQADIRPIVDVYFGRAAQKIVDLIRKRWKKYPDIQCFYVLGGGAAALRPYILEAAENMRLRFVEDSELQNVYGYLKLARNKMNQSEPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJX7</accession>
    <name>A0A398CJX7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ger(X)C family spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_24355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKC lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01489">
        <property type="protein sequence ID" value="RIE01489"/>
        <property type="gene ID" value="D3H35_24355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008844">
        <property type="entry name" value="Spore_GerAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038501">
        <property type="entry name" value="Spore_GerAC_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35789">
        <property type="entry name" value="PTHR35789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05504">
        <property type="entry name" value="Spore_GerAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02887">
        <property type="entry name" value="spore_ger_x_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="397" mass="43798" checksum="834F00D4F17A88DB" modified="2018-12-05" version="1">MALCFALTGCWDRTELNELAITAGTAIDWKEGRWVVTYQVVIPSAISAVLTAVGGGAGKVPVIVYSTEGETIREAVAKSALESPRKLFFSHNRVVVISSAAALHGLENLLDIYLRNPDTRETVSTLISDKDARTILEQLMQVQIIPSDGIEETVKGEAEQLSTLPHVRMYNLAMSLAGPAHSAALPEILVSGDQGVTSADDLSQTSLKSKLRLGRLGLLRDNRMVGWLSRSEALGVAFISNKVSETSIIFSCEGDGAKPNSTFQIEHSKTKLRPEWKNGELVMHININSSGTLVETGCSVEDLNNPATIKQMEKQLRLQVLEQVETSWEATKKLKTDVLGFADIIRRKYPKRWKEVKTDWPNQFSKIRIDPIVSVRIARMGLSSKPYKTLLEKDGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK61</accession>
    <name>A0A398CK61_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_29865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00277">
        <property type="protein sequence ID" value="RIE00277"/>
        <property type="gene ID" value="D3H35_29865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017436568" evidence="4">
        <location>
            <begin position="25"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="302"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="372" mass="38846" checksum="F4B0BB0B8AFC1B34" modified="2018-12-05" version="1">MNRLKAIAALLLATVIVTGTSAAAASNDNGSVKLDAKLINGEVYVKASSVVAQLGGSGTYDATSKKYTYTMGSIVPDVIKRVSPSVVAIIGKPDDANAGNRYSLAHGTGVIVKKDGWILTNAHVVKDMKSIVVVTSDGQELTGTRKQMDVTSDLALVKVSATNLKPATFAASPLKVQAGETVIAIGTPVSFALRNTATVGVISGMNRSVSSDYNLLQTDAAINPGNSGGPLVNLKGEIVGINSMKFVDVDIDSMGFAIPADTVQYVLNHFYKYGKVKRASLGLELEESWSAIVGLPTDEPMTVTAISSPGAEKAGIRVGDELYAVGGKQVSTIVELNELLKSYLPDQKVSITLLSDGDLVTRQLTLSASLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK64</accession>
    <name>A0A398CK64_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4435 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_24905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01589">
        <property type="protein sequence ID" value="RIE01589"/>
        <property type="gene ID" value="D3H35_24905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_15" evidence="1">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase_AAA_core" evidence="2">
        <location>
            <begin position="188"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="587" mass="67448" checksum="791648E2BF8EF98A" modified="2018-12-05" version="1">MVIKCEVQNFKGFTNKTVIFNSFSVVVGQNNIGKSSILHAILLGHEIIKRGITNTRRGYELKNTTLTLDDLKIIPLSTVDSIWLNNKFTQTNEAKIKLYYTETSWIEVSMTRGKNRNVSIIFQQENITDELLVDLVNELAPFALLVPGLAGIPSKEAYVGKYSRTKSITVGDANLVLRNVVASLGMNDEKKFDFERLQLILKKMFPELKKIKTEYNEKINEFLIVEYEREGSTELFDIVTAGTGFLQSLQILSYIFEYKPKVLLLDEPDSHLHANNQVLLIEELRSLSREMGFQIIISTHSREILQGTPPNSIVWVNSEDTATPGVDEGTLVQAYIDLGGLDKLDKIRLNQHAATLLVEDEDLTVWNKLFAKRLGDDWESFVLISTFKGKSNRVALFLTSEFYRKHFATRRVGFVIDHDYDSETKLQEYFDEANRQQIQPHILKAHEIENYFITPDVIRRALLSNGIRLEIDEVREIINSAIQETITDHKYKLMDKLQIEDRRITPSYADSKAHEIIEEKLKDFDEAISWLRGKPILRRIRSLVQEKYSKNLPDSILIDSLYETNNPEILSIFNWVKVIEPEAVTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK74</accession>
    <name>A0A398CK74_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DeoRC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_21300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03113">
        <property type="protein sequence ID" value="RIE03113"/>
        <property type="gene ID" value="D3H35_21300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DeoRC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="76" mass="8450" checksum="B3DC5254C257BDBF" modified="2018-12-05" version="1">MENGDSIILDSGSTTIEIAKQLVNHTKLTIITNDLYIASTVAFHPSTQVMVTGGMKREDVNVLIEILQRRFSVRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKC5</accession>
    <name>A0A398CKC5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4367 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_09365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03756">
        <property type="protein sequence ID" value="RIE03756"/>
        <property type="gene ID" value="D3H35_09365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025377">
        <property type="entry name" value="DUF4367"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14285">
        <property type="entry name" value="DUF4367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4367" evidence="2">
        <location>
            <begin position="199"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="319" mass="34924" checksum="31F61C01D290D3EE" modified="2018-12-05" version="1">MEKGAFLQRNCGRASRDGGYDSAEALPRANESEKQTAAGMGENEVNKTDSEFDILFDQAFEQAFDYSPVAKDELGPDDHRPSWIALQPQLAALRRKQKLRSNLTRVAIVASSILLGAVIFGNTQAAKAIEPLVDTIKESPGGVYTFIFGRSDDNHTDGALTTPPPDFSPSEQGGDGQLLGEGIEVPLDQLQSRLTFAVPEFTYLPQNYSNSRTTVNIRPTQNSKKSSFVMFNFEKEDGYVLHVQMEKFKSETGLAMKTPKTGISVDKIELSTGPAILTVSTNGLTALETFRNGIYVYMSGKVSSDEMIAMFEGMRTPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKG9</accession>
    <name>A0A398CKG9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4183 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01378">
        <property type="protein sequence ID" value="RIE01378"/>
        <property type="gene ID" value="D3H35_23705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025237">
        <property type="entry name" value="DUF4183"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13799">
        <property type="entry name" value="DUF4183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4183" evidence="1">
        <location>
            <begin position="28"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="106" mass="10873" checksum="710946ADAFE33FB7" modified="2018-12-05" version="1">MPLSIINIHVNVSGDSTRFFNVLAAPLAITDGTTVAATTFTTDAGAAATAFPVVSNGYYNLYINGVLQEGDAYTVSATELTFNGVTGTLSAGTPLIVEAVELTTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKL1</accession>
    <name>A0A398CKL1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diaminobutyrate--2-oxoglutarate transaminase</fullName>
            <ecNumber evidence="5">2.6.1.76</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Diaminobutyrate--2-oxoglutarate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-2,4-diaminobutyric acid transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_12840</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + L-2,4-diaminobutanoate = L-aspartate 4-semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11160"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58761"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="2.6.1.76"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amine and polyamine biosynthesis; ectoine biosynthesis; L-ectoine from L-aspartate 4-semialdehyde: step 1/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.76" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000038">
        <property type="protein sequence ID" value="RIE03253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03253">
        <property type="protein sequence ID" value="RIE03253"/>
        <property type="gene ID" value="D3H35_12840"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00067">
        <property type="reaction ID" value="UER00121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045303">
        <property type="term" value="F:diaminobutyrate-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019491">
        <property type="term" value="P:ectoine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004637">
        <property type="entry name" value="Dat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43552">
        <property type="entry name" value="PTHR43552"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE03253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="294" mass="32607" checksum="2F534B9B6A81561D" modified="2018-12-05" version="1">MTTGALAVTSNTRLRTNQAQPGVHFMPYPYCYRCPLGLKRDSCGLSCAKYLENALDNSHSGVDKPQRYWSSRFKEKEGRSFRLPAICGSCAGLRTSTNRCLYSTKSRPASAYGSDVRRRAFGRDADVMTMSKALGGIGYPISCIAYDKRLDTWEPGAHIGTFRGIRRRWQQAMPPSTSCGTPACRSMRRSWGALARPSEFVRAGFGSDRRSSGQGLMLGIEIVKDKHTKEPWPELVKEIRTACYKKGLLVEVGGHFSNVVRFLPPLVVTKELAEKGLGIFIEALESVVRSRQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKN0</accession>
    <name>A0A398CKN0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03866">
        <property type="protein sequence ID" value="RIE03866"/>
        <property type="gene ID" value="D3H35_09970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="82" mass="9047" checksum="CCF38BE62D76406D" modified="2018-12-05" version="1">MESIRDRREACHSGSLLQSHAGRSFHVQTKQTIQLKLPLDRTSPFGVATLPFAHESSPVCGSTSTLSKRAGRLDSEYFRGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKT2</accession>
    <name>A0A398CKT2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_28200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000054">
        <property type="protein sequence ID" value="RIE00497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00497">
        <property type="protein sequence ID" value="RIE00497"/>
        <property type="gene ID" value="D3H35_28200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="3">
        <location>
            <begin position="318"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="492" mass="55489" checksum="39C358CC8B458F36" modified="2018-12-05" version="1">MGIMRRLYRGFIDLKIQDKIFLCFVVVIIASVLGIGISSYYKSSAIFGKKTSRYNVETVQQISTSVDYTLERIDDLSGILAFDQTIQRVFNTDMGAMSERETIAAVNEIESIMITHYNSQIMRSIEIYGNNGLVVKVPSSFNEQGNGPTPKQFVEMASVYRGKTKWLNDAQEHGLLYAVREINELQTAVKPLGTVIISLKSSMVADLLKNVDFDQSGAVLLMDENGSPVIASEPFGQPQAVEEIRQIAAFSSGSSIQTIGGERYFVSFRTSEYTGWKTVGIISLDKLYEDSRMIREWMIVVTLVILLFAFVLARIFAQTITRPIKRMLIPMKKVQMGDLDVSFPSGGKDEIGILSTGVNHMVSQIHSLVEESYRGKILLQQSELKALQAQINPHFLYNTLESINWMAKMNGLTHLRHGDRSGDLMRISINTEKEFITVEEEIKYISDYLYIQKVRFGDRVRPISEWRRAASIVIPKLILQPIVENALLHGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL28</accession>
    <name>A0A398CL28_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH LytTR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04036">
        <property type="protein sequence ID" value="RIE04036"/>
        <property type="gene ID" value="D3H35_08775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH LytTR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="127" mass="14542" checksum="173757E5D37C740F" modified="2018-12-05" version="1">MSFITLLDRNGKPVVIEMNDVLSVTSTSDGPVFHTRVGQLYYPTTLEELQTAYSVAGFERLDRTNLVNLNQVQAFDQKARRVYFDNPWDKESKFATVSEANVHKVEHLTKEETAAYKPARKPLFGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL73</accession>
    <name>A0A398CL73_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_17240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03165">
        <property type="protein sequence ID" value="RIE03165"/>
        <property type="gene ID" value="D3H35_17240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="268" mass="29360" checksum="2E710BF2D5D83FAA" modified="2018-12-05" version="1">MFGLLGRNGAGKTTLMKILAALQSKKAGKVTVCGIPIENAKEIRKITGYLPQEFSIYPSMRVAEAMDYLGLLAGMNGRERKERTEMLLDRVNLIEHRNKKVKALSGGMKRRLGIAQALLHDPKVLIVDEPTAGLDPEERVRFRNLLSEAAAERIVILSTHIVGDIEATCEEIAILDSGKLLYRGTVAALLQTAGGKVFTKAAEKNEVPGLKLKYAVTGMHTQGNKTYIRLWSDTPVPDAEVCEPNIEDAYMRYLYHNGASADPAGGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL92</accession>
    <name>A0A398CL92_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_20770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03030">
        <property type="protein sequence ID" value="RIE03030"/>
        <property type="gene ID" value="D3H35_20770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017299960" evidence="2">
        <location>
            <begin position="33"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="574" mass="64210" checksum="9BC53D3F3D11A7F2" modified="2018-12-05" version="1">MATKRKWPVVLMSTALAAGLLAGCGNNNGNNASPSASSPAASNSNANESASPEKLDPITLSFYSEDPNPNWSNMQDDIGKAITAKTGVTLDAEFAVGDPIQKSALIASSGKYPDVISAKTSISKFVDAGAVLDLTELIDKYAPNIKKIFGDQMNRLRYSLDDKSIYVIPTYDAVGHQPFNAGGGFELQHRVVKELGYPAIKTVKDYENAIKQYLAKHPTDENGNKNIGLTLNSEDWHMYISVTNPAFYTTGAPDDGEFQVDIDTQKVTYHYLRPEEKEYFRWLNHMNAEGLLDKESFVQKYDQYKAKIASGRVLGLIDQDWDYGDGERALKEAGKFDQGYGHYPVTLDEKYKDTSFWPTGYNPSSGIAISKSNPDPIRTIKFLDYLASDEGQVLVNWGIEGKQYNVENGKRVIPKEVNDRKINDGINFQKETGIGSYVTMMARYGDSVKDPTGNYYTTNFPEQIVAGFNDVEKEVLKAYNATTWKDLFPKAEEFPVKPWGASWSIPIPGDSDIPVIEEKLKNITWKMIPKAILAKPENFDSVWDDYVKQLEKANVHKAESLREELIKNRIELWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLF5</accession>
    <name>A0A398CLF5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000038">
        <property type="protein sequence ID" value="RIE03255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03255">
        <property type="protein sequence ID" value="RIE03255"/>
        <property type="gene ID" value="D3H35_12850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="238" mass="26080" checksum="92958E752E7317FE" modified="2018-12-05" version="1">MVQADRARLRRQADGGLHAGCIQLVTPSTSGITSVSQLKGKTIGIDRIGGGPQITLSISLKQQGIDPEKDVEWRAYPNQQLATAADKGEIDAFIVWDPAAQQAIDEKKYVRLLSNGHDEPFKSGYCCYTVISGKVANEDPEKAAAITRALLKASEWVGKNPKETAEIESGKKYVSADAATNEKLLASYHWNPGVKTAAESVKFFVKYQKELGILDKTTDEKELFDRLFYAAVPDYNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLV6</accession>
    <name>A0A398CLV6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_12220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03425">
        <property type="protein sequence ID" value="RIE03425"/>
        <property type="gene ID" value="D3H35_12220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="340" mass="37108" checksum="C271FBF9498FFF06" modified="2018-12-05" version="1">MIKLSVLDHTHVAEGLSVKQSLELTVRLAQEAERLGYTRFWVPEHHSMLSIASSSPEVMIAHLAARTETIRIGSGGVMLPHYSAYKVAENFRLLEALYPGRIDLGVGRAPGGMPIATRALQEGKIGHVDLYGEQIADLAGYLHDSLPESHRFAGLQASPAIPTAPELWLLGSSGGSAHIAAAQGTGFAYAQFFGVPGSEDAVPYYEERFKPSQLNEKPKALSAVFVICADTEEEADRLGQSADLFFLLLETGRLRSSFPSAQAAAEFPYTELDKERMKAGRRRRFVGTPAQVKARLTAYANQYGLEELMIVTMVHDFEARLNSFRLLSEAFGLLGNGKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLW2</accession>
    <name>A0A398CLW2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Stage III sporulation protein AA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">spoIIIAA</name>
        <name evidence="5" type="ORF">D3H35_26445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00837">
        <property type="protein sequence ID" value="RIE00837"/>
        <property type="gene ID" value="D3H35_26445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014217">
        <property type="entry name" value="Spore_III_AA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045735">
        <property type="entry name" value="Spore_III_AA_AAA+_ATPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19568">
        <property type="entry name" value="Spore_III_AA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02858">
        <property type="entry name" value="spore_III_AA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="144"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="313"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="356" mass="38198" checksum="41BFEE026564C3F3" modified="2018-12-05" version="1">MFPGPLKEVLLLLPGQVLESLEEIRVRERRPLEVGYGGRSGFVKPDGTLTEDYRSAYVPGAGECRNLLERVTNHSVYAVEEELRRGYITVAGGHRVGLAGRTVLDRGAVSHLRDVAGFNVRIARARLGCSSGVLPGLLDWKAKTIRHTLIVSPPQQGKTTLIRDMARSISSGEWHHPGAAGWGGRKVGIVDERSEIAASDKGVPTFDLGPRCDVLDACPKAEGIMMMVRSLSPEIVVVDEIGRPEDAYAVNEALHAGVRVLATAHATSLADVFARPVLARLAEDGVFGAFVLLSRSGGRVEHRIVSAEDALAEARSGGARMRAAARDAPEGKPKERPIPSIRSPNEPDSGGGNRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLX9</accession>
    <name>A0A398CLX9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_11170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03260">
        <property type="protein sequence ID" value="RIE03260"/>
        <property type="gene ID" value="D3H35_11170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="371" mass="40248" checksum="5EC03BE082F5AFB9" modified="2018-12-05" version="1">MTEGTVPADVQLRSDSLPPPKRKSWRIEIDPTRSSSPWWMTVVSVALALVVCGIFIWANGMNPLAVYKKMVVGAFGTSFGITETLVKSIPLLLCGLGVSVAYRISVWNIGAEGQFALGAIFATSVTIYFPEWPIYLSIPAMVVMGILGGGLWGLLTAIPRTYFQVNELITSLMLNYVALLLLDYFVFGPWKDPKGFNFPGSPMFNDAQSLPIFGDTRLHFGLIFALLAVGLYAFMIRYTRWGYELRLIGSNPEAARNAGIRINRHILLVMIISGGLAGLAGMSEVAGVTHRLMYGISPGYGYTAIIVAWLAKLNPVGLIVSSFLFGGLIVGGYSVQTLGIPSSISSMLQGAILFFLIAGGTISKFRLRRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLY1</accession>
    <name>A0A398CLY1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_26145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000047">
        <property type="protein sequence ID" value="RIE00857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00857">
        <property type="protein sequence ID" value="RIE00857"/>
        <property type="gene ID" value="D3H35_26145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="50" mass="5839" checksum="470C7E3453135D2B" modified="2018-12-05" version="1">MYGAMLSPFCIFMYSGFMRAIPYELEESAYLDGCSPARTFFQIILHLFCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLY5</accession>
    <name>A0A398CLY5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_13935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01878">
        <property type="protein sequence ID" value="RIE01878"/>
        <property type="gene ID" value="D3H35_13935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028964">
        <property type="entry name" value="Imm8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15586">
        <property type="entry name" value="Imm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="123" mass="13867" checksum="E2674DED1F8C1098" modified="2018-12-05" version="1">MILIIPEVKSIIITGNPTIIGKLEIDETVDLGDDFLLSGTACIGTKESSACDNFDFTVISPKALDRKLNTTNLINGRACFIVKDFDIKLLKERIDDIISNCLGETWEEIAQKLSPYFYWEYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CME2</accession>
    <name>A0A398CME2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_12265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03432">
        <property type="protein sequence ID" value="RIE03432"/>
        <property type="gene ID" value="D3H35_12265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="178" mass="19380" checksum="C14558B894776C77" modified="2018-12-05" version="1">MVMKWYRENVWAAVLVTVARIYLGWQWLDAGWHKLTADNAFNAGGFLKGAVTKPVADHETGAMIFPNYTYFLDHFALPNVKLINFLIPVGEFLIGLGLIVGGLTLTAGLFGMLLNFLFLFAGTVSTNPWLLLIGFIVFTAGANAGRFGLDRYLTPLLRKGWKKLFAGKAAGGGGHVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMJ3</accession>
    <name>A0A398CMJ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_22125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01117">
        <property type="protein sequence ID" value="RIE01117"/>
        <property type="gene ID" value="D3H35_22125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="96"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="308" mass="33088" checksum="51BC81A8BAABAB72" modified="2018-12-05" version="1">MVRAVSERVIASLLVIAGSSVLVFVIMYLLPGDPAGSILDPSTASAEAIANLRRQLGTDQPFLQQLADYFGKLLHGDFGQSLLNSEPVLPKIVAHLPATLTLAGASTFISATVGVLLGVLSAIHRNKTIDVVARIVGLLGISMPTFWSGILLLLVFSIHLGWVPAMGSEGWKTLILPAATLGLIGAGFIVRMVRNSMLEVVNEPFIVTLRSKGLSERAIMYRHALRNALIPTVTMIGMLVGEMLAGAVVIETVFSRQGIGRILADAIMAKDFPVVQGVIFFSAIVYVFVNLIVDLSYTFIDPRVRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMV6</accession>
    <name>A0A398CMV6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spore coat associated protein CotJA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03943">
        <property type="protein sequence ID" value="RIE03943"/>
        <property type="gene ID" value="D3H35_08235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020256">
        <property type="entry name" value="Spore_coat_CotJA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11007">
        <property type="entry name" value="CotJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="92" mass="10975" checksum="236704E4C629B471" modified="2018-12-05" version="1">MWSLSWRLKEEFILQQHDGQWREYRPYVSPTDPCPPILIKWYIVPPNQYITFQPMNWPQFSLDEALRKGTLWPPLFSPYSPPSESKEVGSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN18</accession>
    <name>A0A398CN18_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">alr</name>
        <name evidence="7" type="ORF">D3H35_04490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04746">
        <property type="protein sequence ID" value="RIE04746"/>
        <property type="gene ID" value="D3H35_04490"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="6">
        <location>
            <begin position="245"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="397" mass="44296" checksum="10F87B6B461020D0" modified="2018-12-05" version="1">MKRTYRDTWAEVDLSCIRRNVEAIKRKLPPAVKLMAVVKANGYGHGDAETARAAIRAGADYLAVAYLSEALRLRNQGFEQPMLVLTPIRPEDVPLAVRSGLMLTVASADWFEQARRYKSMRSSHKLAVHVKMDTGLGRIGIREKQDWERLLPWLLEDDVVVDGVYTHFATASQPETTFLRKQAARFEEMKAWVKQSGLAFGRFHCANSAAALRFPELAMDIVRIGAAMYGFYPGRLVPSVDLEPALSLHSRIVQTKKLSKGEFVGYDLAYRTNGEEWIGTVPIGYADGWAQSLRDSDVLVEGQRVSVIGKIGMDQLMIRLPHYVPEGTKVTLIGKQGNERITCAELAGHLDSVPQELSTSLSDRICRIYDKQELRADRFVRASRSSSLSAALSKLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN24</accession>
    <name>A0A398CN24_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-oxoprolinase subunit A</fullName>
            <shortName evidence="1">5-OPase subunit A</shortName>
            <ecNumber evidence="1">3.5.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-oxoprolinase (ATP-hydrolyzing) subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pxpA</name>
        <name evidence="2" type="ORF">D3H35_10085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10348"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.5.2.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex composed of PxpA, PxpB and PxpC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LamB/PxpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.9" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03640">
        <property type="protein sequence ID" value="RIE03640"/>
        <property type="gene ID" value="D3H35_10085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00691">
        <property type="entry name" value="PxpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="PTHR30292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="257" mass="27108" checksum="EAE63E352A3C1860" modified="2018-12-05" version="1">MTQRPLTVDLNADIGEGYGLYDFGCDGELLEVVSSANIACGFHAGDAHTMRRTVERCLSKGVSIGAHPGLPDRLGFGRREMAASPEEVADWIVYQIGALQAFVAAAGGVLRHVKPHGALYHMASAKPEIAEAIARAIRSVDSSLLLFGPAGTFLEKAALSQGVSFVAEGFADRAYLPDGRLAPRQLAGAVIEETERAVSQAVSIVKEGRSVAIDGSWAAVRAETICLHGDAANAAERARQLKQGLEAAGIKTSFPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN44</accession>
    <name>A0A398CN44_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_21335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01001">
        <property type="protein sequence ID" value="RIE01001"/>
        <property type="gene ID" value="D3H35_21335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="26"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="256" mass="28011" checksum="4270BDF7398372C6" modified="2018-12-05" version="1">MSKPQLGIQLYSVRDLAEKDFLGTIRQIAEIGYKNVELAGYYGVSAKDLKQALADNGLHASSAHVGLTVNEPEKLEENLKQQIEYAIELGLPKFVVPGYPLPENPTAGDVAKFIDTLGRAADVVTAAGLAFGYHNHAFEFKPAPSGKLIIDELLESIPANKLFAEFDLGWIKVAGQDPAAYVAKYAGRLPLVHAKDFKPDGVDTEIGRGTVDWDTALAASEQAGVEYVIIEQERYDISSLESAQLNFAWFKERGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN88</accession>
    <name>A0A398CN88_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">HlyC/CorC family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D3H35_08245</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0053 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03945">
        <property type="protein sequence ID" value="RIE03945"/>
        <property type="gene ID" value="D3H35_08245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="6"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="230"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="293"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE03945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="455" mass="51095" checksum="528AEFBF808F30F7" modified="2018-12-05" version="1">METEFHWGSIVWNVFIVLFLVFLNGFFVASEFALVRVRQSRLTQLSNEGKVLARYALKVNKKLDAYLSATQLGITLASLGLGWVGEPAISDLIVQPLLYKFGITDPTVVHTIAYIVAFSLITFLHIVLGELAPKSLAIQRSVGVSMWLSWPLLMFYRMFLPIIWLLNGTANRLLKLVGVEPVGEHDAAHTEEEIRILMNESAKSGIIDKDEMTLFDNVFEFADRVAREVMLPRTDMDCLFTGATLADNMKTVYSTKHTRYPVGVEDKDQIIGFIHITDLLTADPDEEHDLTEFMRPILSVPESMEISKVLKLMQRKKSQLAIVIDEYGGTAGMLTAETILEELVGEIHDEFDDELPSVIVKGDVTSVEGRMLIEDVNTMFGLEIEDDEVDSIGGWLFNHLEGNIAKGQKVEAHGFVFEIVQTERLRVQRVHIYRRKAAKPEPAAEQASVVSPKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN96</accession>
    <name>A0A398CN96_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">mfd</name>
        <name evidence="11" type="ORF">D3H35_23755</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01387">
        <property type="protein sequence ID" value="RIE01387"/>
        <property type="gene ID" value="D3H35_23755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="626"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="808"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE01387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1174" mass="133443" checksum="8BACE7B5A50011E2" modified="2018-12-05" version="1">MKPLIQSFVTDPELVSVMTGVRGGMREQLVAGLSGSARQVMLASFYRELQRPMLILTHNMFAAQKMAEDLQECLSTEEVLLYPANELIAAETAISSPETSAQRLEVLLKLAEGFRGVVIVPFAGVRRFQPDRHTMAEARLDLKVGDTRPMDGFLRTMIEMGYERVDRVEQKGHLSVRGGIVDFFPLASPVAYRVEWFDDEIDSIRTFDPADQRSVDKLEAYTVRPCREWIANDRRFKNAAQHASDLLEKQLEKMSDKQAKDRLRSEISREVDLLRQNVYFSEIYKYISLLYPERQTLIDYMPKDTVLFMDEPNRLAETARQLERDEVEWSTHLLSQGKSLPGFVLAVPAEQALYPKGFQTIYLSLFVRQVPHTQPQNIVNFVCRAMQSFHGQMNVLKAEMERWRKSGSRILMLAGNAERADRMRRVLEDYQIESPEILQGNLQSGFELPSVKLVVITEGEMFTQKQRKARRVDRHLDNAERIKSYTELKVGDYVVHQNHGIGKYLGIGTLEVAGIHKDYLHIVYSGGDRLSVPVEQFDLIQKYVGSEEKEPKVSKLGGADWNRVKSKVQSSVKDIADDLIKLYAERQATSGFGFGEDTPYQNEFEEMFPYDETADQLRAIREIKADMQTPRPMDRLLCGDVGYGKTEVAVRAAFKAAIEGKQVAVLVPTTILAQQHYETFRERFSGYPFNIRVLSRFRSRKEQTDALKGLKAGTVDVIIGTHRLLSQDVVFKDLGLLIVDEEQRFGVSHKEKLKRLKTNVDVLTLTATPIPRTLHMSMLGVRDLSVIETPPENRFPVQTYVVEHSPTLMREAIERELARDGQVYYLFNRVQGIYQMAEQISALCPEARVAVGHGQMSEQELERTILDFLDGEYDVLVSTSIIETGVDIPNVNTLIVHDADKMGLSQLYQLRGRVGRSNRIAYAYFTYQRDKVLTEVAEKRLQSIKEFTELGSGFKIAMRDLSIRGAGNLLGAEQHGFIASVGFDLYSQMLADEVQKRKLEWFGKADIPPRAVNTQLDLGVDAYLPPEYIYDSIQKIEIYKKVAAASSMEDIADLFEELTDRFGDPPKAVLNLLAVGRLKVYGRRYGVESIVRRADDTQLKFEDGRAIDVEASKLKDMESKFQGRLTCTVSAQQLNVRLRSRGLDENATLALVEEFLVQYKEVLKSKGELQDVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN97</accession>
    <name>A0A398CN97_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arsenate reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArsC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04083">
        <property type="protein sequence ID" value="RIE04083"/>
        <property type="gene ID" value="D3H35_09065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006504">
        <property type="entry name" value="Tscrpt_reg_Spx/MgsR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01617">
        <property type="entry name" value="arsC_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="122" mass="13898" checksum="805C494EBE15041F" modified="2018-12-05" version="1">MSTSLTVYHLPQCDTCRKAIKQLKEQGNELDTRHIVEQTPTAEQLRELIAASGLPLQKFFNVSGDAYRAMNLKDKLKDMSDEQKIELLASNGMLIKRPIVTDGTRTTVGYKEDSFRTEWRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CND4</accession>
    <name>A0A398CND4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03750">
        <property type="protein sequence ID" value="RIE03750"/>
        <property type="gene ID" value="D3H35_09335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="155" mass="18090" checksum="5CB4956C76B7F409" modified="2018-12-05" version="1">MTFHDWFLIGFAIYAYIADNKPKIISPLYYINSKQKIASDLAINSFFQQNFVTPTDVKDFNNQIENKIGSTFVLFYETYLRGVFVDKPMLRINETDYLVIHQELFMSRAAEGIFDICKKGYQATLEWNSDIILNDTSLISLENLFPLSKFMPRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNF0</accession>
    <name>A0A398CNF0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_28980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00444">
        <property type="protein sequence ID" value="RIE00444"/>
        <property type="gene ID" value="D3H35_28980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="332"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="495"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE00444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="621" mass="72166" checksum="11E2B885308554E9" modified="2018-12-05" version="1">MPFFWRMPSRSIGDIMLGQLHSEGGTAALRKLKPYVNTLRFKFLVAVLVIFAPLVTVLVINNYYSADVVRNQVSQSNKNMLSLYMNQIDRNLEEVDKYLSNTLESDLSVLDMEFPKSRDEDRYNIAKLTLFNTLRDDAGYYPILDAFFVYSEPNSDLLLTQNTPVSYEDRETARNEVRKMLQKADTIDFAKWHVWKGEQDYYLFHLMKSGNVYMGAWISSSKLMVPLSLIDLGKSGAAVITTDKMEPFSHEELIRDKGLDLRFPMDSYSITGDGNDMYLVMGESSTQGNFNLVAIVPESTILQKLPYLQRVSSVISIAAVLFLLLFVFMMRHIFLNPVKRIVVAMRKTRDGNWESRIEQRPTSTEFEIVNETFNRMIEEIHNLKINVYEEKLNHQRAELRHLQLQINPHFFLNSLNIIYNLATVKDFALIQEMSRCLVSYFRFMFRSNSYFVSLRDELSHTANYLRIQQLRFPDIFQYRVDRPEELLDLEVPPLIVQTMVENTIKYAVNMDEPILITVEADKETDEEGNSRLILSIKDTGPGFPDEVLRRLERDDDSSGSETGEQIGIWNARRRLRLLYRERATIEFYNEEANHGAVVRIGIPIEERERGEGDVSSLDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNW4</accession>
    <name>A0A398CNW4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000051">
        <property type="protein sequence ID" value="RIE00604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00604">
        <property type="protein sequence ID" value="RIE00604"/>
        <property type="gene ID" value="D3H35_27480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="185" mass="21261" checksum="4DCF643D92E93C8D" modified="2018-12-05" version="1">METDEERLTIRDPFPTKRTLEIVPLFDWTKVDRAFVDVSYEDPNNGVLEEQSFEFNDKSVATGRFVVALQDANRRQVGFKATIIRKDGTLSEVPQSYTLERRLTVREDMNGHKVVAIRPGDGDFAELKLREIIVKLRYDDPERGLSFADEFAFKSAADRASFEYDYTAEGPAGYQIQIVRRLRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP27</accession>
    <name>A0A398CP27_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Holin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_23180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the bacteriophage holin family. Cp-1 holin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01291">
        <property type="protein sequence ID" value="RIE01291"/>
        <property type="gene ID" value="D3H35_23180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006480">
        <property type="entry name" value="Phage_holin_4_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05105">
        <property type="entry name" value="Phage_holin_4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="158" mass="17540" checksum="B1057002071770E7" modified="2018-12-05" version="1">MDKLITAAAGGFLFPVFEYFYGPGSAVASLMVTLLFFISMDWLSGSRASKKDKTYSSRYGIDGVFRMFFMLLLPAGGHLLDVAFGTPGIVFGVFVFGLLYHTIKSMTANAIRAGWADWLPIHTMEKVTGWVQSEMEYKLSRAAKRMEEREGTPNGKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP28</accession>
    <name>A0A398CP28_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sigW</name>
        <name evidence="5" type="ORF">D3H35_02660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05136">
        <property type="protein sequence ID" value="RIE05136"/>
        <property type="gene ID" value="D3H35_02660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014294">
        <property type="entry name" value="RNA_pol_sigma-W_bacilli"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02948">
        <property type="entry name" value="SigW_bacill"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="24"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="128"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="188" mass="22186" checksum="5CC9F3C50FD58B36" modified="2018-12-05" version="1">MKSLETRLAKLALKGDQRAFAEIVDLYKDKLYHLAYRMVGNRQEAEDVTQEAFLRVYKNLDRYDQNQKFSTWIYRIATNLCIDRLRKRRAVYSLDAESSDHEGLDGYSMLPSDDRTPESELILSETQRLIREAMDTLPVKYKSVMVLRYLQDMSLQEISDVLDMPVTTVKTRVHRGREFLRKKLENKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPA5</accession>
    <name>A0A398CPA5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04413">
        <property type="protein sequence ID" value="RIE04413"/>
        <property type="gene ID" value="D3H35_07455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025942">
        <property type="entry name" value="SpoVIF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14069">
        <property type="entry name" value="SpoVIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="95" mass="11022" checksum="357A258888205BDA" modified="2018-12-05" version="1">MSWQKFGIRPELVQRVKAKMKNDSIKERVKALLDGVSKYDLQDRAKVHRLVKSAARILNEPLSDVQEGQIVSFIIAQKIDPKNMLSLLKLWSMFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPF0</accession>
    <name>A0A398CPF0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GHKL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_08795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04040">
        <property type="protein sequence ID" value="RIE04040"/>
        <property type="gene ID" value="D3H35_08795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039506">
        <property type="entry name" value="SPOB_a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14689">
        <property type="entry name" value="SPOB_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="273"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="454" mass="51591" checksum="737289DABA03A03B" modified="2018-12-05" version="1">MPLWLEITRLVFLVSIPQTFALLTFCFSFLHVPPKNLQRRLLLYTVVHSVYVDILYYIVPVPVHMLNSICASIILCFIMFRDLKAKQIFSLLLFSFILGSIMDLILGILSFYALNIPDQKTMMSTSFYQMLIALYPELLILWLWSWMIRKKDSLSFKRLFAAVMNSERADLTKLITMNGVQSVAIGTVLFLLSIGNENKYGYITIISIFVMIISLLALAFTIFLVVRTQERAVRMTQDIYLGDIDQMFASIRGQRHDFLNHVQVIHTMAQMRKIDQLQQYLGELVKESQGISEIVNHSSPVLAAFIKAKITVAISKSIAFTYELPNRWDSSDTSVKTIDIVKILGNLVDNAFDEVASLPQIERIVHVIVRHEEDGLTLEIRNKGRVLNDSELARIFLPGYTTKRAGHSGLGLAIVLERVGSYNGKLDVRSNEKEGTVFRIVLPQQEALAVKSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPG6</accession>
    <name>A0A398CPG6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_13510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01807">
        <property type="protein sequence ID" value="RIE01807"/>
        <property type="gene ID" value="D3H35_13510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="377" mass="41796" checksum="626431ACF2B5601B" modified="2018-12-05" version="1">MLNAILIDDEEIALDVLEILLLEIGGIAVAGKFRLAADAIECAAGLKPDLIFLDIEMPGTNGLAAAELLLSRYPDAEIVFVTAHHQYAVEAFDTNAIGYLLKPVAKEKLVKTLGRYTALQAKAAKRRGDSSGAATGGADRESSGGGAGANAGVGSTVRKPLNLKAMGSLELYDAEGRLVTWRTKKTKELFAYLWHHGGSPVYRYRILDHLWPELAADRAQTLFHTTLYNLRSTLRTAGFPEAVAFGDERYWMRTDDIGCDADRLDAILRAGDTAEFAEELLSLYRGDYLETEYYGWAESRRYELRSAFIRYLDKAVGKAGMTATEPMLRKLIEYEPYRERSYDLLLQHLTATGDTAGADRLRQSKNRIFDQELGLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ93</accession>
    <name>A0A398CQ93_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Calcium-translocating P-type ATPase, SERCA-type</fullName>
            <ecNumber evidence="13">3.6.3.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D3H35_07270</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.8" evidence="13"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04380">
        <property type="protein sequence ID" value="RIE04380"/>
        <property type="gene ID" value="D3H35_07270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="717"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="749"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="790"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="820"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="861"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="899"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="12">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="920"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE04380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="942" mass="101892" checksum="DB605B0320675CC2" modified="2018-12-05" version="1">MEGKTWHQIDVTELASRLGTDPKNGLSAEEAAQRLQRHGANELQERKGESPLKLLLNQFKDFMVLVLVGATVISGLLGEMLDALTIIAIILINGILGFFQEFRAERSLRALKELSAPSAKVVRDGTLLTVPANSLVPGDLVHVESGDRVPADLRFIECSQCSVDEAALTGESVPVVKSFQPIAAEELPLGDRKNCGYLGTMVTRGTAKGIVTVTGMSTEMGKIADLIQQTEEAETPLQRRLEQLGKILIVVALLLTVLVVAAGVLHGQPLYEMFLAGVSLAVAAIPEGLPAIVTIALALGVQRMIKRRAIVRKLPSVETLGCASVICSDKTGTLTQNKMTVTRLWVGGDRRIDVTGEGYGPAGLLQEAGKTIDPKGDAVLRRLTQVAALCNNAELAREERSEEPKRRKAAGKAGEGEADEQYEWKVKGDPTEGALLVLATKTGLPRTSLDKLYDRAKEFPFDSERKRMSVLVDHQGGRLLCSKGAPDLLVERCGYVLWGDHVVPFTGTLRQKVLQANEAMAKDALRVLGFAYRDVKPHETCETEETAENGLIFVGLAGMIDPPRKEVEEAIVKCRQAGIKTVMITGDHGTTAEAIARSIGIIPRGGRVISGAELNQMNDADLDKVADEVNVYARVSPEHKLRIVQALQRRGHVVAMTGDGVNDAPAVKAADIGISMGITGTDVTKEASALVLADDNFASIVAAVEEGRGIYENIRKFIRYLLASNVGEIMTMFLAMMMGLPLPLVPIQILWVNLVTDGLPAMALGVDQAESDLMRQKPRSAKENIFARRLGWKIISRGILIGVCTLAAFMLTLGSGASDAAALTHAQTVAFATLVMAQLIHVFDCRSSRSIFHRRFFENKFLVLAVLSSLLLMLAVLYLEPLQPVFKTVPLSLRDWALVLVAAGIPTFLMGIGSVLGTSKPKRRSNRIDYRGTGTQPRPFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQC1</accession>
    <name>A0A398CQC1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_25090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01621">
        <property type="protein sequence ID" value="RIE01621"/>
        <property type="gene ID" value="D3H35_25090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="325" mass="37049" checksum="5E5D2BAEAA38C4F3" modified="2018-12-05" version="1">MTKLTIQQIADIAGVNKATVSRVLNGNMNVSQKTQEKVEKVIREHNYVPNTIARGLAFNKTFTMGFCHDYTDKRAFANPFFYKMLQGIENVVYRNDYLFLMMSHPTGQQKKSMFERMVSEQRVDGIILPSTLLNDSSFQLLTANRMPFVVLGEKEFAHRNVHWVDVDNVQAAESLTERLIGLGHRRIWIFADRASIERDKFIQDRIAGYSNVMAGHGLPSFVVSRLESLLTKESGINDNSLLPDAVICCTHDQLFSILDEEKKEGSPAEFELATFDDNPLFQYLSKTVHYISIDLEQMGEQAATLLFKKINQEEDIPDMIRIPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQD4</accession>
    <name>A0A398CQD4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HupE/UreJ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_20570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02998">
        <property type="protein sequence ID" value="RIE02998"/>
        <property type="gene ID" value="D3H35_20570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032809">
        <property type="entry name" value="Put_HupE_UreJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13795">
        <property type="entry name" value="HupE_UreJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017263456" evidence="2">
        <location>
            <begin position="27"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="375" mass="41759" checksum="878FA9BD50D4CCFC" modified="2018-12-05" version="1">MKVVSFIAALPLLLLASLLQAQPAQAHLNTFGYSDIRLEGSKLVYDLYLDPREVSQWMDLRSNGVFVLESKKALAPDETSWTEEDIRPLVAESLIVKGGETAVEPSSIGDLSISRRGDVPYLRMKLVYELPATAAAYSIDYGFFYEEDPGHQNYATIRAGDSSKDVVFTKDDHQFAASLANAEESLMETTVSVPNWLATLWDYLQVGIEHIWTGTDHLLFVAALVLVKQRKWDYLKVLTAFTIGHSITIALAALDIFNLPASFVEPVIALSIAYVAVENIWMKQVKWRWIVALSFGLIHGFGFAQVLRGALGDRFILTLFSFNLGVEIGQLAVLAVLLPLLIWLGRYKGYQYVNYAASGLIALIALYWFVIRISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQJ3</accession>
    <name>A0A398CQJ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Efflux RND transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_24265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01691">
        <property type="protein sequence ID" value="RIE01691"/>
        <property type="gene ID" value="D3H35_24265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017264578" evidence="2">
        <location>
            <begin position="30"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="835"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="861"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="887"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="936"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="960"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1012" mass="107957" checksum="558618E9D377A9A3" modified="2018-12-05" version="1">MKFFTQFSLRNPVAIVLLVILVAVGGVYAASRFQQEQQPEVMFPGIMVSAVYPGAAPNEVLTQVTQPIEKALKNVEGVKNVSSYSANSVAQLEIEFSYNDDMKEKKNVVQEALNGLPLPEGAEKPEVIFLSTTNQPIMYTTINAKEGVSEEQLTELVKSSVIPDIQAIEGVSNVQAVGLKDDGVYIRLDAKKMSQYGITYEQVTGILQANNLSVPLGEATLNQNKLPVFVQGDLRSVEQLKKWSLTPDGKVKLTDIATIEQGTDNSVLSYTNGQPSILLNITKAGNANTVEVADEVEKVYEKAEKDGKLQSLIMYNRATDVKDSVNTLAREGGLGAIFASILILFFLRNFRATLIAIVSIPLSMLIALICLKYFTDVTLNIMTLGGLAVATGRVVDDSIVVIENLVRRMRGEKLTKELILSGTAEVGRAITSSTITTVAVFAPLGMLQGMIGGFFQPFALTVAFALLSSLLVALTVVPLMAWALLKNQKPKEQKESALSRGYKKALRWSLGHKFIVLALACLLFLGSLVPIFAGAIGVTLLPQGDSKFVFANLVMPKGTELKVVKEEADRLSLIIREHPDVKNTNVTVGGTIEGGLDSNIASWFIGLDPEADIDQFIDEVRPKAKVPEGSEFSFDKEDGVSGGGVAITVTGSSTGDIRTATEQITEAVKGVKGTDNVGNNLRDGTKGIAIEVRQNDASKYGLSAYQASALLRPFLSQTNAGLIDDGSKSSELYLALNGASITSVSDIGNLPIHAPTGETIRVNQIGDVKEVQLPSTLQFKNGAGFATVTAKITDKNTNKVNAEIDKALTKLKLPAGSSYSLGGSDAEIQQMMSDMMMAMLIAVGMVYIVMVIAFREGRTPLAVLFSLPFALIGGLVGTLVGGEPLSVSSMIGFLMLIGIVVTNAIVLLERVHQQIEDGTTIREALIEAGGTRLRPILMTAIATICALTPLAIGLGGSGTIISSGLAVVVIGGLASSTLLTLVVVPVIYELLYYKRSRKQRMASSQAQSGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQK1</accession>
    <name>A0A398CQK1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">U32 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_21080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03078">
        <property type="protein sequence ID" value="RIE03078"/>
        <property type="gene ID" value="D3H35_21080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001539">
        <property type="entry name" value="Peptidase_U32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032525">
        <property type="entry name" value="Peptidase_U32_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01136">
        <property type="entry name" value="Peptidase_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16325">
        <property type="entry name" value="Peptidase_U32_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01276">
        <property type="entry name" value="PEPTIDASE_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_U32_C" evidence="1">
        <location>
            <begin position="336"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="419" mass="46952" checksum="01FE5A23D220C735" modified="2018-12-05" version="1">MSSVLSHDQPRLAGTRARLAKPELLAPAGSLEKLKFAVHYGADAVYIGGQQYGLRSNADNFSFDEMREGVEFAAKYGAKVFVATNIYAHQEDLAGVADYLKELENAGISAIIAADPAIVETAQQVAPKLEVHLSTQQSTMNWQAVRFWKEEGLPRVVLARETSMDEIREMKRRVDIELEVFIHGAMCSSVSGRCVLSNHFTDRDSNRGGCCQSCRWKYDLKADERSVADPEMNLFTMSSKDLCMIDHLPDLIDAGVDSFKIEGRMKSIHYVASVVNAYRQAIDSYMDNPEGYALRSEWLEDIGKAANRPLNTGFFYTTPGAEEHIYEPEEKAAPFDFAAVVTEYDEDTGIATVQQRNFFRPGMEVEFFGPGGRRFVQRVGDMTDVEGNSLEVARHPLQLIRFRTEHPVAPLDIMRKRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQT3</accession>
    <name>A0A398CQT3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Baseplate J/gp47 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01294">
        <property type="protein sequence ID" value="RIE01294"/>
        <property type="gene ID" value="D3H35_23200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006949">
        <property type="entry name" value="Baseplate_J-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04865">
        <property type="entry name" value="Baseplate_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Baseplate_J" evidence="1">
        <location>
            <begin position="62"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="359" mass="38001" checksum="449302CCFF8DEA44" modified="2018-12-05" version="1">MYEAQTFDAILLRMLGRVPADMDKREGSVIYDALAPASAELAQMYAELDINYNLSFADTSSGDYLTRRAAEHGTVRKTATVASRLGLFYNAANEPLDVPIGSRYSISGINYSAASKLALGSYELICETVGVVGNQHFGQLLPIDYVDGLSRAELADIRVPGAEEETDEALRARFLAEINAQPFGGNVGDYLEKIGGLDGVGGVKVFPAWAGGGTVKVTIVDSSYNPPTIALVDEVQTIVDPESNSGMGIGFAPIGHSVTVAGAATVTINVTTTVTLQSGFTIGQVQDNLEAAVEEYLLSLRRNWANVAETIVRISPLEARMLAVQGVADVTGTLFNGTAANVTLTEEQIPMAGTVTLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQT5</accession>
    <name>A0A398CQT5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_04720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04903">
        <property type="protein sequence ID" value="RIE04903"/>
        <property type="gene ID" value="D3H35_04720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="130"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="130"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="231" mass="26603" checksum="B6F58BB6CE726C69" modified="2018-12-05" version="1">MKQHILIIEDEDGIARILQLELEHEGYEVGRAADGRTGLELALSGSWDLLLLDVMLPELNGIEVLRRLRQNDFASPVILLTARDTVPDKVSGFEHGANDYVTKPFAMEELLARIRNILRMSKASREGESEDVLRIGDLTIELLTRKVFRKDHSIELTPREFELLLYLAKHKNGEKTRDEILSDVWGYEYIGDTNVVDVYIRYLRQKMDKGYRHKLLHTVRGVGYMLKEPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQZ8</accession>
    <name>A0A398CQZ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DeoR/GlpR transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_03340</name>
        <name evidence="5" type="ORF">D3H35_26775</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000018">
        <property type="protein sequence ID" value="RIE04942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00797">
        <property type="protein sequence ID" value="RIE00797"/>
        <property type="gene ID" value="D3H35_26775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04942">
        <property type="protein sequence ID" value="RIE04942"/>
        <property type="gene ID" value="D3H35_03340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="254" mass="28346" checksum="985BA75FD81543FC" modified="2018-12-05" version="1">MLVAERYEKIVRLVNERGSIRVSELSELCDVTEETIRRDLDRLEADGRLRRSHGGAVSVKDQQLQSEIPYAQREIAYAEEKQRIAEEAVKRIRPKDRILLDASTTAWYMARIVPDIPLTVLTNSIKVATELASKEKIEVISTGGILAQRSLSFVGPLAERSLDAYHVDKLFFSCKGVHLDRGVSESNELQARIKHRMIGMADEVVLLADSSKFGVQAFTHVAEIGDIDAIITDKRLPDAALARLTERGLPVTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR00</accession>
    <name>A0A398CR00_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5 7">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsL</name>
        <name evidence="9" type="ORF">D3H35_02215</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 5 7">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE04985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04985">
        <property type="protein sequence ID" value="RIE04985"/>
        <property type="gene ID" value="D3H35_02215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="140" mass="15572" checksum="93C439837076411C" modified="2018-12-05" version="1">MPTINQLVRKGRQPKVVKSKSPALQKGFNALKRIETDLSAPQKRGVCTRVGTMTPKKPNSALRKYARVRLTNRIEVTAYIPGIGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGALDTAGVNNRKQARSKYGAKRPKVKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRD0</accession>
    <name>A0A398CRD0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_04295</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04710">
        <property type="protein sequence ID" value="RIE04710"/>
        <property type="gene ID" value="D3H35_04295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="19"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="337"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="373"/>
            <end position="380"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE04710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="600" mass="66525" checksum="F917C37AA3E86F3E" modified="2018-12-05" version="1">MDIFRNLKAYFWQDKGFMFGSVFGLAVATALGMVYPLLLRTLIDDMIVPGKFDGVLGLALLAVGIIVVKAAFQFLHGFSGGRLGNRLAYRLRNACYSKLQELSFSFYDTARTGDLMSRLTADIEGIRNFIGFGLAQLMNTVFLVIFGFSMMFAIDWQLALMTFVMIPILGFVAIRFEQQIHPVFRAIRSSVGKLTVSVQENIMGVRTVKSFAREPFEVKKFSVNNDEYKRYNVEISGVWARFFPLMEFIANFSVAILILVGGWRVIEASLTLGELVALNGMLGLIVAPLWTLGFQINNYTQSKASGERLLELLNQPISVRDDSHSMPLDENAVTGHLKFNDVRFRYANREDHPSALVGFNLDAPAGSVIGLLGGTGAGKSSAVSLLFRAYDVTEGAITLDGIDIRHIELESLRSRTAIVFQESFLFSTTIQENISYGCPGATMDEIVEAARLAQADGFIRELPLGYDTVVGERGMGLSGGQKQRIAIARALLRKPKVLILDDATSALDMETEQEIQKALLTVMKGRTTFIIAHRISSLRHADEIVVLDRGRVAQRGNHEKLLRQPGLYRETFRIQFADRPEELDSSPVASGGENDRRVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRE6</accession>
    <name>A0A398CRE6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03839">
        <property type="protein sequence ID" value="RIE03839"/>
        <property type="gene ID" value="D3H35_09820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="217" mass="25233" checksum="C81E00DE60BA0DEE" modified="2018-12-05" version="1">MRCCELLAMPERVTGGGDAMLREFSHARAGYWRRDAMLRAFSHARAGYWRRDAMLRAFSHAGAGYRRRDAMLRAFSHTGAGYWRRDAMLRAFSPTGAGYRRRDAMLRAFSHTGAGYRRQDAMLRAFSHTGAGYWRRDAMQWDEVTFFRRFVDANAQQWDGVTFFRRFVDANAQQWDEVTFFRRFVDANPQQWDEVTFFRRFGCGGSTVGRGNILSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRG8</accession>
    <name>A0A398CRG8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase CwlD</fullName>
            <ecNumber evidence="2">3.5.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cwlD</name>
        <name evidence="2" type="ORF">D3H35_02415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.28" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05133">
        <property type="protein sequence ID" value="RIE05133"/>
        <property type="gene ID" value="D3H35_02415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014234">
        <property type="entry name" value="Spore_CwlD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02883">
        <property type="entry name" value="spore_cwlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MurNAc-LAA" evidence="1">
        <location>
            <begin position="129"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="252" mass="28199" checksum="B00A30A24E2EEF76" modified="2018-12-05" version="1">MLSVHRRFVVWMTRRGWIRLTVAAGLMLLTTVVFFTEIPTARTWTHWTHPMSGIVIALDAGHGGADGGAVSKDGIIEKDINMAIVLHLRDYLQQAGALVLLTREGDHDLALPDTKGHSRRKTEDLIERAEKVQEQRADLTISVHMNSIPSPKWSGAQTFYHPRNPESKRLAADIQAEIREALGNTDRVAKQADKTVYLLKTLEMPTALVEVGFLSHPEESRLLADEEYQRKVAASIYRGILRFNSGSGERAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRT0</accession>
    <name>A0A398CRT0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05263">
        <property type="protein sequence ID" value="RIE05263"/>
        <property type="gene ID" value="D3H35_01710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="144" mass="16537" checksum="88FE0790F9D178CA" modified="2018-12-05" version="1">METGKNETITVETTVQKPVGEVWRYWTQPEHITKWSFASEDWHAPNAENDVRAGGKFITRMEAKDGSFGFDFGGVYDEVRINEFISYTLDDGRKVAITFISQENDTKIIEAFEAETANPIEMQKAGWQAFMDNFKKYSEACKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRT2</accession>
    <name>A0A398CRT2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gluconeogenesis factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_21415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for morphogenesis under gluconeogenic growth conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconeogenesis factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01644">
        <property type="protein sequence ID" value="RIE01644"/>
        <property type="gene ID" value="D3H35_21415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00973">
        <property type="entry name" value="Gluconeogen_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010119">
        <property type="entry name" value="Gluconeogen_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30135">
        <property type="entry name" value="PTHR30135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01826">
        <property type="entry name" value="CofD_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="330" mass="35813" checksum="3B3B4149561C355F" modified="2018-12-05" version="1">MQAQQKPKAVRLPRIVVIGGGTGLSVMLRGLKQKPLDITAIVTVADDGGSSGILREEMQMPPPGDIRSVLTALADAEPLLAEMLKYRFQNGTGLAGHSLGNLILAAMTDITGDFVTGITELSRVLAVRGRVLPAANQAIVLKAEMNDGTIVVGESTIPKSGLEIKRVFIEPADVEPLPEAVQALRDADAILIGPGSLYTSIIPNLIVPKLAEAIVQSDAVKIFICNVMTQPGETDNYSVSDHLSAVHAHIGHHLFDYVIVNNGEIPPQVQSLYAEKGSKAVHLDLEEVERRGYKVIADKLVLFRTYLRHDADRLSEHIYQLVEDWMQRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRZ2</accession>
    <name>A0A398CRZ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_15350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02131">
        <property type="protein sequence ID" value="RIE02131"/>
        <property type="gene ID" value="D3H35_15350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022138">
        <property type="entry name" value="Helicase_SWF/SNF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12419">
        <property type="entry name" value="DUF3670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="506"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="811"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="991" mass="111376" checksum="E37B499E712689E5" modified="2018-12-05" version="1">MNGITDTITIQISLTEHGDALIFGSLSEHHYLTGLYLKQRLFAWHEPSFYGTELAIQSVQDFELVSLPSEQVISFFADRKLLRHVEWKWSGFAERLVKAAPALARCIEEKRFLPSFDAYRIGKLQWTWDVEALEPLEKAALDAPSEGSAESLALEDGMRAAFSAAVFARHYGTEATSADLRREYPLLFTKGDSAGLDSEAWLVAVGWKADIAPFRPVLQLLEPDEFGEDEPAWGLRLILQDKLDEAAIAAVRLSENGEAFGSWPSSWTALVRERSASWLERLHACLPAERFAGGREDVLNGPLEDEAAWKFLTSDSNRLLEAGWQVLLPAWWEAARRKKPRLRAKINSGAGGKAGGSLFGLDSIVDFDWRIAIGDADLSEAEFAALVARNERLVRFRGQWISLDPALLAQIRKAMGRMDKSQGLSFQDVLQLHLLGGEDGDEGGQSNQLSEEEDSERIRLEIELNEHLVKLIGQLGQQSDWPKLEAPSGLRAELRAYQRDGFAWLAFLRRFGLGACLADDMGLGKTVQLIAYLLHLKEDADKHTGTSKNVRSPSLIVCPTSVLGNWQKELSRFAPSLDVLLHYGSRRLAGDDFYAEVRNADVVLTSYATAALDQDTLKEFTWAAICLDEAQNIKNAQTKQSAAVRSFPARHRVALTGTPIENRLSELWSIYDFITPGYLGSSRSFQERFGNAIEKERDERATADLQKLVKPFMLRRKKKDPSIQLDLPDKNEMKTYVHLTAEQGALYDQTVNQLMEKMQKLEGIERKGAILAALTQLKQLCDHPILLTKEPLSANADGWIDAEPLVGRSSKLERLLAMVRELREEGDRCLIFTQYVGMGEMLQRVLQQELGERVLYLNGSTSKSARDRMIEQFQARDLPDDEQPSVFILSLKAGGVGLNLTAANHVFHFDRWWNPAVENQATDRAYRMGQTRDVQVHKFISLGTLEERIDEMLESKQQLSDNVISSSEGWITELSTEALKDLFTLRREWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSI9</accession>
    <name>A0A398CSI9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FMN-dependent monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_14130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01914">
        <property type="protein sequence ID" value="RIE01914"/>
        <property type="gene ID" value="D3H35_14130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="147"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="219"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="467" mass="51777" checksum="37A2F3991221D208" modified="2018-12-05" version="1">MAKKRQIKLAAYMVGTGMHVASWRLPDARPDASIDIDFYRRLAQTAERGKFDIAFLADSLAINEQSHPNILNRFEPITLIAALAGATSRIGLVATASTSYIEPFNMARLIMSVDHISKGRAGWNIVTTRDLSGNTARNFGAEEHLDHGYRYKRAEQFLEVVRGLWDSWEDDAFVRDKDSGRFFDPGKLHRVNHKSEFFSVEGPLNIGRSPQGQPVLVQAGISDAGQHFSAKVGEVIFSIKYSLEDAKSFYQSYKDKLAAVGRNPEEVFILQGISPIIGRTEEEAREKLKRLEGLITEETGLSFLTDYFQGVDFSGHTLDSRSEELGLGQLELTKSDYKKHQEVIVRENPKLRELYSLLTGSFSGDHLVGTPEKIADTLELWFTEGAADGFMLMAPSLPDGLEDFVELVVPLLQERGLFRLDYEGSTLREHLGLPVPANRYSLPFAEAATEADSTATAVAASGNAPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSM6</accession>
    <name>A0A398CSM6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_05815</name>
        <name evidence="6" type="ORF">D3H35_19425</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000026">
        <property type="protein sequence ID" value="RIE04521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02807">
        <property type="protein sequence ID" value="RIE02807"/>
        <property type="gene ID" value="D3H35_19425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04521">
        <property type="protein sequence ID" value="RIE04521"/>
        <property type="gene ID" value="D3H35_05815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="132" mass="13923" checksum="C9257C4F6CD6405F" modified="2018-12-05" version="1">MEWGLLLLRVVIGLLFVGHGMQKLAGWFGGYGLNGTGGFFESIGIKPGKTMAFLAGLAEVAGGLLFAFGFLTPLAALLIVGTMLIAIIKVHGKNGLWVTQNGYEFNLVLIVIAIAVALIGPGDYSLDSLWID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTW4</accession>
    <name>A0A398CTW4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000028">
        <property type="protein sequence ID" value="RIE04148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04148">
        <property type="protein sequence ID" value="RIE04148"/>
        <property type="gene ID" value="D3H35_07825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="315" mass="36004" checksum="12A7E6CE081FA6DD" modified="2018-12-05" version="1">MRTIRKVKERIAMQEKKKYRYRQAAAAIVCTVLLGAGYLLRDDLADWMRKAPAAKPVISDDEEVRLSVQYYDTGSLLQRYSTFIIRHPSVRLEAVSPPQGEAYTAEGYVSWAKKSSADIFQVPLAYVDDMSREGLIKPLDAWIKRDSYDIESLYKPVVQAIREAGAGQLYGLAPSFETYALYYNKTLFNAANIPLPKDGMTWEEVWNLAAQFGESPKGNDIAGLSFGDTRPPRRFPFWAKHGFAANIRRRQAAYYRYSRLAKSAGTAGSRMEGRMDQQATAQKERGRYTHEGFVYGRPLFNGEIRHVIRQFYLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU29</accession>
    <name>A0A398CU29_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">era</name>
        <name evidence="12" type="ORF">D3H35_06205</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04208">
        <property type="protein sequence ID" value="RIE04208"/>
        <property type="gene ID" value="D3H35_06205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Era-type G" evidence="11">
        <location>
            <begin position="6"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="10">
        <location>
            <begin position="204"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="8">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="8">
        <location>
            <begin position="40"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="8">
        <location>
            <begin position="61"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="8">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="8">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="61"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE04208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="298" mass="33597" checksum="325890503EC56780" modified="2018-12-05" version="1">MKQPFKSGFVAIIGRPNVGKSTLMNQVIGQKIAIMSDKPQTTRNKIHGVYTTDEAQIVFLDTPGIHKPNSKLGNYMVKAAEDALNEVEAVLFLTDVSEELGGGDRYIIERLKRVNTPVFLVMNKIDKVHPEALLPIIEKYRKLHDFTEIVPVSALQGNNVNTLLEQITKYLDEGPMYYPADQVTDHPEQFVCAELIREKILQMTREEIPHSIAVEIESMGTGDNGVVNIGAVIYVERDSQKGIVIGKNGALLREVGKQARQDMERLLGSKIFLELWVKVKKDWRNRESVLKTLGFRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUF6</accession>
    <name>A0A398CUF6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GGDEF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_20070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02911">
        <property type="protein sequence ID" value="RIE02911"/>
        <property type="gene ID" value="D3H35_20070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="10"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="280"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="349"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="437"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="603" mass="67469" checksum="5F7FECDC84122EA9" modified="2018-12-05" version="1">MDNDVGVWFGKQSPERLEEAIDRQSSEVRYSPIASLLDGSVFGYEAVPWDEQAGAAWDAGRFFEQADKQGSLYDADRRFRESAIRGMAPLLTHVKLFIPVPARIIYDARLYPGNTLYRIEAAGLRPENVVLLLVDQGEGHSDTLIAAIRHYRLQGFRIALSGIGADRVSFRRLVELKPDYARIGGEWLPAHARDHAGESLFQAICLLARKEKIVLLAEGVAQEEQLRALMTHGVGYAQGEWIGESGERLEPIRREASERIRLEMRSKYHGSAGAGALVELLEPATTFSRRTPVSEVAQHFERHRETNGFVIVDDDKRPVGLLMKEKLHQMLAWQFGLPLYWNRPVDKIMDTQPLVVDQATSVDQLSQVAMAREPDKLYDAVVVTKNGRTEGIVSIRSLLEWVTNARMADAQSSSPLTGLPGNEPIRRELTRRLEDGRPFAILYADLDYFKWYNDKYGFHRGDDVIRFTSEALQTVVKEHGADESFVGHIGGDDFIVMTYYGNPVKMAEETLAFFEKGISSFLNDERGPSSDRSGKPLSGAALSLSLALLICRNADGWTPEKLAEYSALLKKRAKEKNGSSLAWEALGAGEGMDDRDKVVFTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUZ5</accession>
    <name>A0A398CUZ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome C oxidase subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_10335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03687">
        <property type="protein sequence ID" value="RIE03687"/>
        <property type="gene ID" value="D3H35_10335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017201841" evidence="2">
        <location>
            <begin position="32"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Cupredoxin_1" evidence="3">
        <location>
            <begin position="50"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="141" mass="14548" checksum="CEACC25437100DBB" modified="2018-12-05" version="1">MKTKHTVFSLLSIAALAMALSACGGNNDDNAASSAPASPSASSSASASAPAAGGETKEITITASNWKFDQTDIKVHKGDTIKLTLKNESGMHAIAIDDLNVEVKSGETKEFTVTDAGTFEFHCSITCGQGHDNMSGNIVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV96</accession>
    <name>A0A398CV96_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03817">
        <property type="protein sequence ID" value="RIE03817"/>
        <property type="gene ID" value="D3H35_09700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="270" mass="30182" checksum="7FCD9C165904D6E6" modified="2018-12-05" version="1">MRILYVTPYLPYEGVPYAGGYFLYEYLVRLSAYVDVQVIAPRTEENELAAAKLRHEFKVELLGDKPVKKSKAARLLPILWNHLVHPMNIPEMDNLSKELGKPGYLDDFDAVEMHFSQALPLAKVVKKARPELPTVIFAHDVFSQSVHRRVRGAPFSPGKLLNAIKSLRVSSVEASYMNRCDGAFVFSDKDKNILGGMGVRTRVEVLVPSVELPRRTAPLEGGPVCLFVGAMDRPENHEAASWLLSNVWPDVLERVPEASLKIVGAILRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVQ8</accession>
    <name>A0A398CVQ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_00805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05399">
        <property type="protein sequence ID" value="RIE05399"/>
        <property type="gene ID" value="D3H35_00805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="126" mass="13627" checksum="B757947819C41166" modified="2018-12-05" version="1">MLYRNIGFYLDSETAVIEIGDHTFLNRRSEVMCKRHVKIGSHCAISWDVTITDTDYHAIEGTEPTRPVVIGDHVWIGSRATILKGVTIGAGAVVAAGAVVSKDVPARTLVAGVPAKVVRENVSWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVS9</accession>
    <name>A0A398CVS9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proline--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="8">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proS</name>
        <name evidence="10" type="ORF">D3H35_11575</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03321">
        <property type="protein sequence ID" value="RIE03321"/>
        <property type="gene ID" value="D3H35_11575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PTHR43382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="SSF64586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="38"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="482" mass="55113" checksum="9A15B0B3F554B46C" modified="2018-12-05" version="1">MSKDKGFVTEITPQGEDFSRWYIDVIKKAELMDYSPVRGCIVFRPDGYELWENMQRELDQRFKDTGHRNAYFPLFIPESFFQKEKEHVEGFNPELPFVTEAGGEQLEEKLAIRPTSETMFGHMYAKWINSYRDLPMLINQWANVVRWEKRTLPFLRTSEFLWQEGHTAHEDEADARKETMTMLDVYTDFVENVLAIPVIKGQKTPSERFAGAVDTYSIEAMMKDGRAVQAGTSHYLGTKFAVAFDIKYLSRENTQEFCHTTSWGVSTRLIGALIMVHGDDRGLVLPPKVASTQVIMIPIGPPKTRETVIAKTDELYAQLKAAGVRVRVDDRSDVSPGWKFNEYEMRGIPIRLELGPRDLENGVCVLVSRVSGEKKQVPIDRIVEEVRALLEDVHRDMYERAQQFREENSFSVDTLDELKEKLEVKRGFALAGWCGSDACESTVKQETGATSRNIPFETKEKKPTCLVCGEASEHTVVFARAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW04</accession>
    <name>A0A398CW04_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_04335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04718">
        <property type="protein sequence ID" value="RIE04718"/>
        <property type="gene ID" value="D3H35_04335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="164" mass="18194" checksum="9F289012CC7E641C" modified="2018-12-05" version="1">MEPAADFVKSWMKLTKDWNALLEAELAPQLTAGQLEVLELLLAHEPMKPSDLLPYLETTPAAITTLLDRMERAGLVVRNRNEGDRRIVWVTMTELGRSEVERGVKVRTDVANRSLDRLSSHNRQLLVYLISKVAGTRDAAAAAERQASAKPQSEDETEVGTNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWD7</accession>
    <name>A0A398CWD7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_08835</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04137">
        <property type="protein sequence ID" value="RIE04137"/>
        <property type="gene ID" value="D3H35_08835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="13"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="248"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="284"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE04137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="510" mass="54792" checksum="57714EF89C0567F6" modified="2018-12-05" version="1">MGQDLLAELAEGARVSLLVGIVSALAATAIGALIGLIAGYSGGWTDTVFMRIVDVSMTLPYLPLMIVIGVYMGPSLHTQIGVITLIMWAGKARELRSQIMALRGRGPVLAAKSMGASHVYLLRKHLLPGILPLLIPQFVRAVNMSIILESSLSFLGLGDPLAKSWGSILYYANVRNAFLTDSWIWWVIPPGVCIILTVLSFSLLGYYLEERVSPRLRGASSHARWANWATALAGNALKPKSGEAGPVLEVEGLTVTYNRTGEAVLALNHVDFTVCKGEIVGIVGESGSGKSTIASSIMGMLKQPAEVSGGFIRLQGEELNGLPPEALRQLRGRRMALIPQAAMNALNPVLTVGAQLAEAVRAHRSIGKAELRRLVEQALEQVGLSSDWSSAYPHELSGGMRQRVVIAMALINEPALVIADEPTTGLDVKVQIEIIKLLEQLQGRLGISMILISHDLPVVLRLADKIVMLENGKIVDEGEAATLARSPSHPYTRRLMEAIPRISATKAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXR3</accession>
    <name>A0A398CXR3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Beta-galactosidase</fullName>
            <shortName evidence="6">Beta-gal</shortName>
            <ecNumber evidence="3 6">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D3H35_08695</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 6"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04021">
        <property type="protein sequence ID" value="RIE04021"/>
        <property type="gene ID" value="D3H35_08695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013739">
        <property type="entry name" value="Beta_galactosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013738">
        <property type="entry name" value="Beta_galactosidase_Trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003476">
        <property type="entry name" value="Glyco_hydro_42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36447">
        <property type="entry name" value="PTHR36447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08533">
        <property type="entry name" value="Glyco_hydro_42C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08532">
        <property type="entry name" value="Glyco_hydro_42M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001084">
        <property type="entry name" value="B-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Glyco_hydro_42" evidence="10">
        <location>
            <begin position="20"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42M" evidence="11">
        <location>
            <begin position="404"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42C" evidence="12">
        <location>
            <begin position="628"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE04021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="693" mass="78132" checksum="0480189B292A4626" modified="2018-12-05" version="1">MSSKFPPISGKIPGFMHGADYNPDQWQHDPQVLDEDIRLMKLAGCNTMAIGIFAWAALEPEEGRYTFEWLDRVLDRFAENGLFAWLATPSGARPAWMSEQYPEVLRVGANRVRNLHGQRHNHCYTSPVYRDKTGTMNRKLAARYAGHPAVVGWHISNEFGGECHCPLCQDAFREWLREKYGTLDELNMAWWTSFWAHRYSDWPQIESPAPHGESMVHAHNLDWKRFVTDRTVDFCKHEISCIREVGSDLPVTTNMMNWFAGLDYRKFSDVLDVISWDAYPTWHESKDDSQVAAWFAFNHDLFRSLKGKPFMLMESTPSVTNWQPISKLKKPGMHKLSSLQAVAHGSDTVQYFQWRKSRGSSEKLHGAVVDHVGHERTRTFRDVSELGASLGSLADVVGTKVDSRVAIIADWDNRWAVKNSQGPRNAGIHYEQTVMEHYKAFWQLGVPVDIIGSGDGYDFGRYALIVAPMMYLCRSETGAKLEKFVSDGGTLATTYWSGIVDENDLCHLGGFPGPLRTTLGIWAEEIDGLYDDERNGIVPVADNALGLAGEFEARELCELVHLEGAEALAIYRDDFYAGRPALTVNAFGSGEAYYLATRAFAPFYESFYGKLAVKLGIPRALESELPDGVTAQVRTDGETDFVFVQNYSGAERIVRLDGRSYRDAETEEELASFELTLPVNGVRVLKRNQVASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXR4</accession>
    <name>A0A398CXR4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000008">
        <property type="protein sequence ID" value="RIE05328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05328">
        <property type="protein sequence ID" value="RIE05328"/>
        <property type="gene ID" value="D3H35_01015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="91" mass="10464" checksum="04C2F0B553AF2DB8" modified="2018-12-05" version="1">MPQFGRVQSLLEELEQTLLEKSFLYELTILRIMSEVVFLVVNLEEAAGNDSQPRSADELLVGDVLAYLVAHCQEEIRIEDLLWRFPVSRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXU0</accession>
    <name>A0A398CXU0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05348">
        <property type="protein sequence ID" value="RIE05348"/>
        <property type="gene ID" value="D3H35_00725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027618">
        <property type="entry name" value="Beta_prop_Msarc"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04275">
        <property type="entry name" value="beta_prop_Msarc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="789" mass="85800" checksum="2538C3E022592006" modified="2018-12-05" version="1">MYDVSSKKEQQLTTSGKAYTPDINGNLVVWAENRGKSLDIYTYNLSTSQETQITNTDSLNETSPVIAGENIVYSISKGIYLYEIDKSASKKINTLADNDSSAQISFSASGDRVAWYENTLNSGTGKRETAVYTYTISEDKTDTIATGKNQQKPSIYEDKLVWEDRQSDEQSYSTIYFYDLSQQEGKFLDFSGKSQSSPVIYEDNVAWIDGRSGTNQIYVYNLTASSGETITTSNGAKASVDIYEDTLVWSVSSNIYSNKDIGPSAADAVNQAVDVKALKNLLENQEIGLTLGSYSGWKNGDKDAVVANVFAARPDQGYASVADVQTAFDNALTSRTPLANVNLATNVATLAEALEDTKLQLDLTALAALNETDRDAALHAMLTDRPSNGYASKENLQIAVIAAVLSWTTSSWKYVGEQAMKGWFGDLAVNRQGKLYVAYQDNENQDKATVKTFDGTSWQTVGSAGLSAGAIQTAMALSFDSNDRPYVAYSDSTKGNKVTVKRFDGTAWQLVGSEGFSEDYPFYLSMVIDKDNVPYVGYRASNRGYVKKFNGTSWVNAGTGALASGDISYLSMDLDSSGTPYVAFEGSDGKAVVKKLSGSSWNDVGNPGNTGPAYYMQFALGANDTPYVAYVDTQDEMKLVVLQYSGGSWVRVNIQNPPKLQTPHFDFAIYKGTLYITLYDVTHEKRATLMKLVSGVWTSVDSPGFTDGSVDIEISKFVFFNDVVYIGFLNRYSPISNTTTVISNNNLNGDPTYSIGALGDNTLLPLDAGYASGKQETRSIAIQKTGSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZQ2</accession>
    <name>A0A398CZQ2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartate 1-decarboxylase</fullName>
            <ecNumber evidence="9">4.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aspartate alpha-decarboxylase</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="9" type="primary">panD</name>
        <name evidence="14" type="ORF">D3H35_04125</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H(+) + L-aspartate = beta-alanine + CO2</text>
            <dbReference type="Rhea" id="RHEA:19497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="4.1.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="9 10">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooctamer of four alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9 12">Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PanD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.11" evidence="9"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04681">
        <property type="protein sequence ID" value="RIE04681"/>
        <property type="gene ID" value="D3H35_04125"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004068">
        <property type="term" value="F:aspartate 1-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006523">
        <property type="term" value="P:alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06919">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00446">
        <property type="entry name" value="PanD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003190">
        <property type="entry name" value="Asp_decarbox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21012">
        <property type="entry name" value="PTHR21012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02261">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006246">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00223">
        <property type="entry name" value="panD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5017499330" description="Aspartate 1-decarboxylase beta chain" evidence="9 13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017499329" description="Aspartate 1-decarboxylase alpha chain" evidence="9 13">
        <location>
            <begin position="25"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 11">
        <location>
            <begin position="73"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="9 10">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="9 12">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE04681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="127" mass="14183" checksum="7BCDD74FB1489E6A" modified="2018-12-05" version="1">MFRQMMKSKIHRATVTEANLNYVGSITIDQDLMELVDILPDEKVQIVNNNNGARFETYAIPGPRGSGVICLNGAAARLVQPGDLVIIIAYGFVTDEEARRHHPRVAIMDERNRVVKLLAEEPHSTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0P1</accession>
    <name>A0A398D0P1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GGDEF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04734">
        <property type="protein sequence ID" value="RIE04734"/>
        <property type="gene ID" value="D3H35_04425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="59"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="196" mass="22393" checksum="2900A7D983FC5F3E" modified="2018-12-05" version="1">MVEYQPHLILIVRDVTAQKENQREITFLAYHDPLTRLPNRRYFYEKLEAALKDADNQSHKLAVVLFDLDHFKEINDRYGHQIGDKVLLHVANIVREIVSSQGMAARLGGDEFVFFLHPVASENLVLELIHRLRQVIERNKLLVDNEAIPITLSIGASFYPVNGVDGDGLLNSADKALYEVKRKGRNAYRMLSEGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0T3</accession>
    <name>A0A398D0T3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05111">
        <property type="protein sequence ID" value="RIE05111"/>
        <property type="gene ID" value="D3H35_03000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="231" mass="25975" checksum="AB4E3F563AA14012" modified="2018-12-05" version="1">MAAETGKPEKRTKVRAIVTGATGMVGEGVLHECLQHPDVESVLVVNRKPCGVTHPKLTEIIHSDFYDLSPIESRLAGYNACFFCLGVSSVGMKEEEYSRKTYDLTIHMAERLAGLNPDMVFCYVSGVGTDSTEKGKSMWARVKGRTENRLLRLPFRRAYMFRPGYIHPTKGLNNTHRYYAALTWLYPVLRRVWPGSVITLREVGKAMIHSVTNGYENAILHSKDIAKLARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0Z7</accession>
    <name>A0A398D0Z7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_05095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04844">
        <property type="protein sequence ID" value="RIE04844"/>
        <property type="gene ID" value="D3H35_05095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="330" mass="33997" checksum="649C8A275702694D" modified="2018-12-05" version="1">MTTTIRWCLLLGGMLALAIMASLTFGDAFVSPIRAMEAVIGKGTIEEGLLVRTLRLPRTVVALLVGASLAAAGTLLQGAFRNPLAAPDLIGVTGGASVAAVAFVVLRPATLSIAWLPAVTMAGAAVVSALVLALARKGGTLSPTRLILVGIGVGAFMSAMTTMLVVFSPMHTATEAYIWLTGTVYGSSWKHVSTLLPWTVVFLSLAIMNGRRLNALMLGDELATGIGNAVERSRLSVVALSVALAGSAVSMGGVIGFVGLLAPHVARKLVGPLSSRAIPVSALLGGIIVVTADLAARTLFLPLDIPVGVFTSGVGAPFFIYLLFRTRNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1J5</accession>
    <name>A0A398D1J5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="6 8">5.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glmM</name>
        <name evidence="13" type="ORF">D3H35_02680</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23424"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="5.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Activated by phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="6 8"/>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05054">
        <property type="protein sequence ID" value="RIE05054"/>
        <property type="gene ID" value="D3H35_02680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05802">
        <property type="entry name" value="GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01554_B">
        <property type="entry name" value="GlmM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006352">
        <property type="entry name" value="GlmM_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01455">
        <property type="entry name" value="glmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="10">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="11">
        <location>
            <begin position="158"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="12">
        <location>
            <begin position="257"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="9">
        <location>
            <begin position="373"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE05054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="446" mass="47297" checksum="1EF3B76C9023EBF7" modified="2018-12-05" version="1">MGKYFGTDGVRGVANTELTPELAYRIGRCGGVVLAGRAERPKVVIGLDTRVSGPMLESSLIAGLLSIGADVVRLGVVSTPAVAYLTRELGADAGVMISASHNPVADNGIKFFGGDGFKLLDETEAEIERLMDAETDELPRPVGGGIGRVSEDLGAKQRYVEFLRSTVKHSFAGVKIVLDCAHGAAYELGPVVFRALGAEVITLGAEPDGLNINDGVGSTHPELLAAKVKELGADLGLAFDGDADRLIAIDENGEEVDGDYLLCICGDAMKRDGRLKRDTVVTTVMANIGFFKATETLGLKTAKTAVGDRYVMEEMVREGYNLGGEQSGHVIFLDYNTTGDGILTGLQLVDTLIGSGRKLGELKGMMRKYPQVLVNVRVADKSRYPGNEAILAAVASAEAELGDNGRVLVRPSGTEALIRVMAEGPEREEIERHVAAIVDVVRKELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D201</accession>
    <name>A0A398D201_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_02545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05134">
        <property type="protein sequence ID" value="RIE05134"/>
        <property type="gene ID" value="D3H35_02545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="5"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="339" mass="37616" checksum="53446B6707676FA9" modified="2018-12-05" version="1">MAGDNHLLDVQKLKTWFRTEKGSVAAVDGVSFHVREGEFIGIVGESGCGKSVTSQSIMRLLDEKRRVRYEGEVNYRGENLLQLPPSRMRSIRGNEISMIFQDPMSSLNPVFTIGKQLTEAITLHERVSRRAARERAIELLRLTGIPAPERRMGEYPHQLSGGMRQRIMIAIALACRPALLIADEPTTALDVTIQAQILDLLGELNRSYGMSVLLITHDLGVVAEVCSRVLVMYLGQIVEEAPVHELFARPRHPYTKSLMRAVPTLDSDRSQELPAIDGSVPTLYHIPPGCRFAPRCPYADERCTGPEQPPVVQVGEGHSARCWHAESLMEGGARDDDCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D250</accession>
    <name>A0A398D250_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_02100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05184">
        <property type="protein sequence ID" value="RIE05184"/>
        <property type="gene ID" value="D3H35_02100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="209" mass="24184" checksum="1D6F1E1AB31FB7B1" modified="2018-12-05" version="1">MGIHTYFQSLNDLERIIRCPGRFKFEEHSVSAHSWKVVQYAKTLADIEESKGVAIDWKKLYEITSSHDYGEIFIGDIKTPVKHYSLELRAMLQKVEEGMIAHFIDEHIPEEFKPIFRRQLREGKDDSVEGLILEVADKLDQVYEAFTELQRGNTEKEFIVMYRSALIKIKGIQLHCVDYFLNHILPDLVKEGSRSPIDIAKITDEALAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CB73</accession>
    <name>A0A398CB73_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_28710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00396">
        <property type="protein sequence ID" value="RIE00396"/>
        <property type="gene ID" value="D3H35_28710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="319" mass="34013" checksum="2F97D105B2E98520" modified="2018-12-05" version="1">MQLSENEGWPMNSVKLGLRNIPAVYVTLLLVVVVNMMMNHRILSENGINNLAIQMVPTLIAVMAQTCVLLARELDLSVGSNVGLSTVLMSATMEKWGLFSIVIVLVISILIGMLNGALAVYFKVPGIVITLATSMIVTGGALLILPTPGGYVSLDYARFVLGHHLFVPNTLFILAAVLLCWKYLRMHPWGHSLLATGGNEYSAYASGLKVQRSKILAFTLSSVLAAIAGMVLAAKTMSGDANIGTSYTLTSIAGAVLGGVSFLGGVGSMRKAIAGAVVIVLLVNILFFIGISSFYQYIFQGVILLVSVVVTLRNQNNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CC50</accession>
    <name>A0A398CC50_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-serine dehydratase</fullName>
            <ecNumber evidence="1">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sdaAA</name>
        <name evidence="3" type="ORF">D3H35_28415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00350">
        <property type="protein sequence ID" value="RIE00350"/>
        <property type="gene ID" value="D3H35_28415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004642">
        <property type="entry name" value="Ser_deHydtase_asu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="SSF103378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00718">
        <property type="entry name" value="sda_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_alpha" evidence="2">
        <location>
            <begin position="16"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="293" mass="30430" checksum="14F84FA63D976D14" modified="2018-12-05" version="1">MRFKTLSELASLAQAENKPISRLMIEEQARESGESEDVIIARMASYYGIMKEAVAKGLSEDTTSRSGLTGNDGKRVNRFAGEEQPSVGQDAAKAMAYALSVSEVNASMGRIVATPTAGSCGVIPGVFVSAQERFGWKDDDLVNGLFCAGAIGHVIANRSFISGAEGGCQAEIGSAVAMAAGALVELRGGTPEQSMHAAGLALKNSLGLICDPVGGLVEVPCIVRNGFGAVTALAAADMAMAGVRSVIPSDEVIDVMLEVGRAMPEKHRETAKGGLAQTPTGKAIMQKLNRQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCB6</accession>
    <name>A0A398CCB6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_26900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00816">
        <property type="protein sequence ID" value="RIE00816"/>
        <property type="gene ID" value="D3H35_26900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_TE" evidence="3">
        <location>
            <begin position="7"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="232" mass="26457" checksum="3B31CE0FB9895D21" modified="2018-12-05" version="1">MNGTKLFCFAYAGGSASIFLGWKKRLSDHLEVVPVEYAGRGSRFSEPLCENIEEMLSDLVKQISIRMDGSPFALFGHSMGSLLAYELAYRLRESFGMLPTHLFASGQSPPHRKECKKMIHALPRDEFMAEVTEIGGTPPQFFEEPDLQELFLPVLRADFKIVETYRFMEKSAPLDCDITVLSGARDDGIQGDLREWEKHTRGKTAFYELDGDHFFIREQEESILNIVRNHIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCI7</accession>
    <name>A0A398CCI7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00906">
        <property type="protein sequence ID" value="RIE00906"/>
        <property type="gene ID" value="D3H35_25375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="238" mass="25417" checksum="910F6D63D0C9369D" modified="2018-12-05" version="1">MGRGTILSAIGGGERSTVERGTILSAIGGDERSTVGRGTILSAIGWDRRAIVGRGTILSAIGWDRRATVGRGTILSAIGGGERSTVGRGTILSAIGWDRRAIVGRGTILSAIGGGERSTVGRGTILSAIGGGERSTVERGTILSAIGMVQTRNSGTRYHSFGDWRGRTLNSGTRYHSFGDWRGRARNSGTRYHSFDDWHGADAQQWDEVPFFRRLAGANAQQWDEVPFFRRLAGIGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCU8</accession>
    <name>A0A398CCU8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tpiA</name>
        <name evidence="5" type="ORF">D3H35_21365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01006">
        <property type="protein sequence ID" value="RIE01006"/>
        <property type="gene ID" value="D3H35_21365"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="251" mass="26364" checksum="CD86FEB7B40BE19F" modified="2018-12-05" version="1">MSRTPIIAGNWKMFKTAGEAVSFVSEVKGKAEVAGVESVICAPFTALPALVEAVKGTTIKVGAQNLHFEDNGAFTGEISGVMLKDLGVHYVIIGHSERRQYFGETEEIVNKKTHAAFKHGLTPIVCVGEKLEEREAGTTNEVVRVQTEGAFVGLSAEQASEVVIAYEPIWAIGTGKSSTAADANETISYIRGVVAGLYGADVASKVRIQYGGSVKPNTVAEYMGQPDIDGALVGGASLEPASYVALVEGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCX9</accession>
    <name>A0A398CCX9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_27945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00570">
        <property type="protein sequence ID" value="RIE00570"/>
        <property type="gene ID" value="D3H35_27945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025275">
        <property type="entry name" value="DUF4015"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13200">
        <property type="entry name" value="DUF4015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4015" evidence="2">
        <location>
            <begin position="72"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="396" mass="43968" checksum="1AE70D65AA3D3F24" modified="2018-12-05" version="1">MDILLTLLLLLQSAIGGDGGQHSESSLGKLWHTTQLAIKQQNAKPDKPNVEQPTTSNPSKEDPQKDAPKVKGIYVTAYSAGGARMATLLDLLDKTALNSMVIDLKDDSGFITYKTTNPELTKIGTPQPFIKDITKTMATLKEHQIYPIARIVVFKDTILAKKKPEWSFVNADGSVWSNKKGDRFVNPYRKEVWDYNIAVAKEAAKLGFKEIQFDYVRFPEGFEKKADHLKFTKTEQNRIDIVAGFVAYAKKQLEPLGVRVSVDIFGYAASVPAAEGIGQDFAKISSAVDVICPMIYPSHYSAGWFDQKDPDKAPYATIEGATIATHKKLDSLGDKKPIVRPWIQDFTASWLGKGHYIKYGTAEVNAQIKALNDNNVEEFLLWNAGNKYSPDANYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCY9</accession>
    <name>A0A398CCY9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_28000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00580">
        <property type="protein sequence ID" value="RIE00580"/>
        <property type="gene ID" value="D3H35_28000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008773">
        <property type="term" value="F:[protein-PII] uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018821">
        <property type="entry name" value="DUF294_put_nucleoTrafse_sb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005105">
        <property type="entry name" value="GlnD_Uridyltrans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03445">
        <property type="entry name" value="DUF294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10335">
        <property type="entry name" value="DUF294_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF294" evidence="1">
        <location>
            <begin position="43"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="DUF294_C" evidence="2">
        <location>
            <begin position="211"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="351" mass="39612" checksum="15E772945CC78B13" modified="2018-12-05" version="1">MSRSRWEKRLQQEIGSASDPEMLQMLRNKEQNRLLALVSISPINSVVDAMNELQDAIISRALELVENDLARLGLGAPPVPYAYFLFGSGGRSEQTMTSDQDSGIVYANPANDDEKERCELYFEQFGQTAVQYLVRAGYPPCEGNVIASNPEWRLSLHDWERKIDGYFNEPSWENVRHLLIIADGRKVAGDISMAEEFRERFFSDMLSNSVIVRRMMENTLRHKVLVGAFGQLLRERYGKDSGSLDIKYGAYIPMVNAFRLLAVQAGIHESSTLGRIAGLQHAGVLTLGEAEEASSAFSFLLRLRLLTLGNGKIPRDQLTKELTQPLKKALKIGKKVQRKVERELQYRFGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDQ3</accession>
    <name>A0A398CDQ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">G-D-S-L family lipolytic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00843">
        <property type="protein sequence ID" value="RIE00843"/>
        <property type="gene ID" value="D3H35_26815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="45"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="234" mass="25502" checksum="19C921A00D037855" modified="2018-12-05" version="1">MMTERIAMIKPGKFGSAAAADGRRDEFDYGNEVILTHGVSVDFVFIGDSITHMWELNAYFARGGKFVVNRGIGGDITSHALRRFDADVVQLKPKHVVIKIGINNFWELEAWIAADRKPADAIADGAAADIGAMIRKAKDAGITPVVCSVLPTNMPFTGHDAERNRGVNRLNAVLRKIAGVEGAIYVDYHSRMLSEDGTKLRDGLADDGIHPHVAGYDIMADALREELSKHGISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDS7</accession>
    <name>A0A398CDS7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR02206 family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00790">
        <property type="protein sequence ID" value="RIE00790"/>
        <property type="gene ID" value="D3H35_26740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011737">
        <property type="entry name" value="CHP02206_TP0381"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09529">
        <property type="entry name" value="Intg_mem_TP0381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02206">
        <property type="entry name" value="intg_mem_TP0381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="238" mass="26163" checksum="568FB4626CFC4995" modified="2018-12-05" version="1">MGFEAFSPAHWAALAVAAVVVAAIVLGRNRLRSPRANRAVRIGLAATLAGCEAALQASYAMAGEWGYEALPFQLCSIMVWLSAVLCFWRNRVLYEIVFFLGILGALQALLTPNLDETFPQFRYFHFFAGHIAIVAVPVLLTAVDGYRPNFRSALRALGWLHLLAIPAAITNAAVGTNFMFLARKPSTASLLDLLAPWPWYLLELELVAIALCLLLLAIVRLTDRVMKAKAHSKEVERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDW7</accession>
    <name>A0A398CDW7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tyrosine-protein kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00903">
        <property type="protein sequence ID" value="RIE00903"/>
        <property type="gene ID" value="D3H35_25360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="466" mass="51185" checksum="FCD7135D16EB5A1A" modified="2018-12-05" version="1">MNGVIGMRLFAGRWNGCHCRRGSEPALFNRTWLDVFCQSWYRNGTKNERKRKHRNRRAMREVAVLFCVPGEGGDMAVNVVIAIGNRDYAAKLSRYLREAEPEWETAAVTQQAALRRELASFGQVDLLAASPEFLADAGESKGSAAIRSRVALVEYQGQGGGARELSLYQPFPQLAAAIRSILLDNEIGCNREARAGTLTLGVFSASGGVGKSTIALNVVRQAAERGWRTFYLNMETLDPSGTLFGAGEPDRLSRLLYAMQAYPERFGEELGRAIKHQPTLRADYIDAPDHPGERMAMTSEQLEKLIQGIRDIGRYDIVVVDSDSGATDKHKRLQNCCDRVLWVVTDEWTSMVKAEQLHRYWQGEASGTPIGITYVLNKKIGELMNGWKLPGRGPDAVLPYIPQWKAIDQPGKWFLSPAFSGALEAVLDRLGLTEGGPPGASGRSREKEGSHSHGSHGSGGVVRGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEK2</accession>
    <name>A0A398CEK2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">frr</name>
        <name evidence="7" type="ORF">D3H35_11550</name>
        <name evidence="6" type="ORF">D3H35_25930</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000044">
        <property type="protein sequence ID" value="RIE00875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00875">
        <property type="protein sequence ID" value="RIE00875"/>
        <property type="gene ID" value="D3H35_25930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03316">
        <property type="protein sequence ID" value="RIE03316"/>
        <property type="gene ID" value="D3H35_11550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="5">
        <location>
            <begin position="20"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="184" mass="20702" checksum="1E5DC57C6D544269" modified="2018-12-05" version="1">MPQAIKKNAEERMEKALGALKRDLQTLRAGRASSAMLDRVQADYYGTPTPVNQLGSINTPDSRTLIIQPWDKSALAAIEKAILKSDIGLTPANDGTIIRLNIPPLTEERRKDLVKDTKKFGEEAKVAIRNIRRDANDDIKKKEKGEISEDESRRHQEDVQKLTDKYVAEVEKILAAKEKEILEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEL3</accession>
    <name>A0A398CEL3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01606">
        <property type="protein sequence ID" value="RIE01606"/>
        <property type="gene ID" value="D3H35_25005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="287" mass="32977" checksum="1AA616931EE40904" modified="2018-12-05" version="1">MQLFRSANTITYYLETNALYNLANQLELIRPRGIKAYTSFFTVLELLAGIVDTNSYIKRKSILNKLHKSKIDIHWKTPTKVLYDSFGLPYDDSIDIRIVEDMYMRVLESDSYDEFIRAAEKGGDSGKIQSYDKTLSNFGVETSKLFIDSFSKNNSKDRKKEYRKAMFEDKLLHAQAQVNSEILVREHIIDMTGFSPANEYEQYIKVAMAYDRSLKVYFYAEAFHRLLSTVKGEPYGKNDIADHFHLLYISGSTAIVSDDGLLTSLAEGSRIYVCKTAAEFRKMINEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEN4</accession>
    <name>A0A398CEN4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_25370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00905">
        <property type="protein sequence ID" value="RIE00905"/>
        <property type="gene ID" value="D3H35_25370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="DEAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042493">
        <property type="entry name" value="XPD_DNA_FeS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="182"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="797" mass="89254" checksum="C5429E177E453D0F" modified="2018-12-05" version="1">MLDKVTIAVRPLVEYAFRGGSLDAGFRSAASLTEGTKAHQAVQKGYGEADRSEVYVSGEIECDNIAFVIDGRCDGVLASDDGTFTIDEIKSTVRDLALIDEESYPVHWAQARCYAYLYAREHALDRIGIQLTYVQIDTDRQKRFVQEATCDELGDFVSEVLHRYAPYAKMLFEHQRRRDESIRSLPFPFRQYRKGQRTLAGAIYKSIENGTGLFARAPTGIGKTMSTVFPAVKAMGNGLLQQLYYLTARTTTRTAAEEAFNRMKAEGLHLHSVTITAKEKVCFQEQVDCRAEACEFANGYYDRINDAILDVLKRETSIDRTVVESYARKHRVCPFEFSLDAAYASDAVICDYNYIFDPRVSLKRMFAERKAKTALLVDEAHNLIDRAREMYSAELNKRDFMLLEREFKGIRADIGEAAKTINRLFIQLRKQKGGASFALAEKPDELLKAVEAFAAIAENTLAGHGSGHDRSGVGDEEGASFQGWGDGSRDVASASGSDLLLEAYFAASAFVRIGKLYDDERYVTFVEPVGNEVRLKLLCLDPSELLRQAGKGFRTRIFFSATLSPLRFYMDVLGAGENDYSVSVPSPFEAAQWEVAALPISTRYADRADSRAPIVALLGQLLERRPGNYLFFFPSYAYMNDIYEAFCDSCPDQRTMLQGAAMPEEERDRFLAAFDADNESAFAGFAVLGGVFSEGVDLVGDRLTGVVVVGVGLPQIGPERDLIRDHYNATTGKGFDYAYVYPGMNKVLQAGGRLIRSETDRGVLILADDRYLLPHYRRLLPEEWRNFKIIRGEDSYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEX5</accession>
    <name>A0A398CEX5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoporin-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_28910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00432">
        <property type="protein sequence ID" value="RIE00432"/>
        <property type="gene ID" value="D3H35_28910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017355431" evidence="2">
        <location>
            <begin position="30"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="513" mass="56946" checksum="2EB619E1E870E2AE" modified="2018-12-05" version="1">MPVRTVRTIALSAAAVVLIGLCGINLAFGSPFVHSWDEVDFAYALDRYDLLAMQPHFPGYPYFIAGAAAIHRWIADPVRSLTVFNAMLALSSSFPIALLARRWVGAIPAWWATVWVAMSPYLWLMGSRAMSECAGIAVLWWYLWSVRESADKPRSAWKHIVAVSLFGLLMGIRLSFFPFGVGLVLLWALRFRSYGSHENRFVRLGAWVVAASAAQAVWIGGLIMSEGTPAGFWKLSKAFVAGHFSEWGGGVAATRMPILERMATIFGDHLIGDVLLSRSVDLGIFYLILLAAIVWGVWTLRGERAARHPEMTYAMWLGVGLAAYAIWALLGQNVEKPRHIAPVAGPILLAIYIVAVRLIGRLWRASADRRGSLRVVAAAIGMTLAGVYATEAIHGFQLLERQAAQKPAVYQLHDYLSSMEQPFVVYTWEETRVLGYLGASYEHRRIVTFDYFRALSGAAPGSRVLLTDHVLKGFLSQNPEAGAYVRPIAHFRSESLFEPVYAEITLYEWKKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF28</accession>
    <name>A0A398CF28_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_13435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01796">
        <property type="protein sequence ID" value="RIE01796"/>
        <property type="gene ID" value="D3H35_13435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011623">
        <property type="entry name" value="7TMR_DISM_rcpt_extracell_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07695">
        <property type="entry name" value="7TMR-DISM_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017193350" evidence="2">
        <location>
            <begin position="26"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="484"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="619" mass="70321" checksum="F3591003C00CD623" modified="2018-12-05" version="1">MRRHLFLMITLVIVLAGCAKPPSDTDEKPKSFSGRMDLTDSKMKADELVDLNGEWAFYWRQLLEPKDLSSGTEQRTGYIDMPSNWYKHTMDGDKLPRNGFATFALQLRVSDPDQVKGLILPVMYSNYKLWVDDRLVAVSGQVGTDRKSSIPQKSTRVVYFHPQSEQVQLLLQISNYHNYAGGMWEPIVYGSASVIQNKHDWTSAEQYLLLGIIFLSGIYHIGLGSFHKKDSSLFLFGVFCLVAAIRNTTTGVVPLTKLLPNFPWEIGMKLEYITLYLMVLLLALFIQRLFPEESLRRFTRLTFVTVIIYSVLTMALNADQYYRILIYFQLFMAAALLYAMTVFVRATLRQREGAFYAMIGFSVFMLTAAFDLFRFLFTTTAQIVYSLGVVTFIVCFSFVLSKKLAVSFKMTQQLADKLVELNEGLDKKVRERTFVIEESNKKLEKLNRQLREWSMVDGLTGVSNRRHFDDFLSSGLAISREEETPLTLLLLDIDNFKRYNDQYGHIQGDFILQEVAQAVKSCLVPEDGGLAARYGGEEFAVVLPRCGKDGAERTANNICEAVRQLQIPHVQSEAGIVTVSIGAATVDSDADKDYKKLIELADRNLYKAKSRGKNRVCFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF90</accession>
    <name>A0A398CF90_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aspS</name>
        <name evidence="10" type="ORF">D3H35_27830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00552">
        <property type="protein sequence ID" value="RIE00552"/>
        <property type="gene ID" value="D3H35_27830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="143"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="7">
        <location>
            <begin position="200"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="591"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="222"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="535"/>
            <end position="538"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE00552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="615" mass="68928" checksum="560B0536D6B59037" modified="2018-12-05" version="1">MMLKNHDCGTLGQQNVGETVVLNGWVQGWRDFGGILFIDLRDRTGIVQIVFNPAFSGQALDLGARARNEYVLAVKGVVVGRDPETYNPNIATGEIELQVHEVEIINSAKTPPFPIEDGVEVDESLRLKYRYLDLRRPEMQKTLRLRSKATKVFRDFLDENDFIDVETPILTKSSPEGARDYLVPSRVHPGEFFALPQSPQLFKQLLMVGGLERYYQVARCFRDEDLRADRQPEFTQVDIETSFLTQDQLLAMMESLMARLFRETIGVEIPTPFQRLTYNDAIHKYGSDKPDLRFGLEIEDVTDIVKNSDVKVFASVASSGGVVKALNAKGCASWSRKELDDLQPFATRYGGKGIAWITVKEGEWRGPIVKFFKPEEIAALTEKLGVEEGDLLCFSADKLKTAADVMGNLRLKVGRELGLIDNSAFKFLWVVDFPLLGYDEEAKRWVAEHHPFTRPRDEDLELFATDPGAIRAQAYDIVLNGYEVGGGSMRIYRREVQEQMFSALGFTQEEAKKQFGYFMDAFEYGTPPHGGIAFGLDRLIMLLTGRTNLRETIAFPKTASATDLLCDAPSAVFDRQLDDLHIRLSAKAIAAQTKPNASQEGAPQDSQNAEPAAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGP5</accession>
    <name>A0A398CGP5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminoglycoside N(3)-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_14125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2-deoxystreptamine antibiotic + acetyl-CoA = an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12665"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57921"/>
            <dbReference type="ChEBI" id="CHEBI:77452"/>
            <dbReference type="EC" id="2.3.1.81"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the antibiotic N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.81" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01913">
        <property type="protein sequence ID" value="RIE01913"/>
        <property type="gene ID" value="D3H35_14125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046353">
        <property type="term" value="F:aminoglycoside 3-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003679">
        <property type="entry name" value="Amioglycoside_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028345">
        <property type="entry name" value="Antibiotic_NAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11104">
        <property type="entry name" value="PTHR11104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02522">
        <property type="entry name" value="Antibiotic_NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110710">
        <property type="entry name" value="SSF110710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="267" mass="30015" checksum="DED94FBCAC35E248" modified="2018-12-05" version="1">MTTTKETRVVLTKEDLIDQFKSCGVAEGQTIFVHTSLKSLGFVVGGAETVIRALLEIVGEEGTLMMPSQTWKNLDPTTGVHWEVPVEWWPIIRENWPAYDKEVTPAIGMGTVAEMLRKWPGASRSDHPARSIAAVGKHADYLTKDHDLSVIFGKGSPVDKLYELDGHILLIGVGYDKNTSLHLAETRADFPTKRFADESSAIMIDGRRTWVTYNTQAVDDEDFVRLGEEYDAAHSILVHKVGNADVRLLRQRPLVDWSVQWMEKNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH20</accession>
    <name>A0A398CH20_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_28585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00379">
        <property type="protein sequence ID" value="RIE00379"/>
        <property type="gene ID" value="D3H35_28585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="574" mass="64148" checksum="040C21B758F13868" modified="2018-12-05" version="1">MQKRLIPDTLTLEERAGHAMNAIVGMADRDYGDIPFFAANLMNDPANLTHGDWDYGSSHGRMVDAMILARHMSGETFGTDIEEKYRSNLLSFFKEDGLSYRQTNPHHNWEPNANFIDQRAVILSLTTWFMATGDPKAKEAADKHVAALKRVAVKEKDVWYYPASEYKEGGWPSSNAILLRLAPDPAAFCGRLVMPLLKYHQLTGNEDALELCEFFSALIVQRSGVFNADGSFNDALAYRSGHFHTRLGTLDALARFGAFKGDAALIAFVEKSYAWAITQCTTFGWTPGDMKEQAYEHETCSLVDLIATGITLAQSGYTKYWSVVEKYIRNHLAESQLLEMDWVKETSDRSKDVPGLITYHNIGQRTRGAFAGYSAPNDFCCNVNHGRGHTNDLQICCLGSGTRGLYMGWSNTVTEKKGTVSVNFLLNRGSAWLDVESCLPHEGKIVLRIHKDIHRLQVRIPEWAGYAKVKFARELNGETTNGKGSDPSTWVGEHFLLLGGAKAGEVITIEFPLSLRKTIETAVGQTFETEWRGDDVVGISPAGTEHPFYSGRKVYDKAPMREGELRKVENEFVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH93</accession>
    <name>A0A398CH93_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02113">
        <property type="protein sequence ID" value="RIE02113"/>
        <property type="gene ID" value="D3H35_15245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="271" mass="29373" checksum="B1902ED470A161EA" modified="2018-12-05" version="1">MKKGWMWTGVATVVLAAGVGIGTVYYYGSDDTLPDGVTVGGLSVGKQSPEDAIGQLKARIAELEGTKVTIASSERMKDARSLKELGMKIETEDFIGKLEKYRDASWWERARLRMDNELAADHGFQVQWDDKVLEKKIESYWGGFSGEKPIEATRTINERDEVVYTEERPGTALDLAALKKSVKALQPTSLSEGAVGGSKLLSRSLPLPIVETVPNVTLAKLKEEGIERKIAEFTTSFTSSAAGRSYNVTAAAKALNDTLLMPGMCSSTATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHA6</accession>
    <name>A0A398CHA6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_28990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00469">
        <property type="protein sequence ID" value="RIE00469"/>
        <property type="gene ID" value="D3H35_28990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="57"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="289" mass="32400" checksum="F02C3922555C9FB5" modified="2018-12-05" version="1">MMLPGLAYLIINNYMPMFGVIIAFKDINYAKGILGSDWIGFKNFEYLFKTADAYVITRNTILYNGGFIILNTVMAIGVAILLNEVKNKFAARFYQSVILLPFLISMVIVGYLVLSMLSAESGFVNSTLLPMFGIEPISWYFEPKYWPYILTLVQVWKATGYLCVIFLAAIIGIDNEYYEAATIDGANKWQQIRSITVPLIAPTITIMTLLAIGRIFYSDFGLFYQVPLNSGPLQPVTDVIDTYVYRGLMTLGDIGMSSAAGLYQSLVGFILVLLSNYIVSRRNKENALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHC2</accession>
    <name>A0A398CHC2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_23670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01372">
        <property type="protein sequence ID" value="RIE01372"/>
        <property type="gene ID" value="D3H35_23670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="549"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="8">
        <location>
            <begin position="425"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="243"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="244"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="617" mass="62330" checksum="1DD7A818AE9B4070" modified="2018-12-05" version="1">MSTERKEIGIPGDSAQGTLLKGAALLGGAALLSKLIGTLQKIPLQNVAGDEVFGLYSAVYALAVMWITLAAAGVPTAVSVLVAERSADGEDEDAQRVLRWSIVLLGLSGLIAFGLAQAFADTLAAWMGAKDAASAIRTSSIALLFAPATAAMRGFRQGQMKMLRPAVSQIVEQSARVAFMLVMLVWAIEAGWSPSSTAASLHGGLAAGASAGLAAMLWPARKRREPIALTVAARGARKKYGSSGATAVESTSADPVEEPTANAAKSASSSGSAPAAGFARPKKVRMPETRLALVKRIAVVAIPVAIASVAAPLLGLIDAFSVPRLLQHDPQVTSSSAMASFGVYNRGVALLQLILMAASGAAAALVPALTAARARGEGGGEEAAMRAAFTIRLAWWIGCAAAIGLALLASPVNIALFSDNSGSAALAIIAFAAVGGTLQAVSGGLLQGLGELRAPAVNLAAAAILKLTLNALLVPAYGINGAAAAMTLAFAAAALLNALSLRQRIAIPAPRAATMWRPAAALTAMAALTALAAALIAALARALPDRAAALLTALPGVAVGAAAFAASLVAFGALSPQQWRALPGLSAGSRPDRAFTRLFGASIRIHRSAEAEQPWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI03</accession>
    <name>A0A398CI03_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Efflux RND transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01642">
        <property type="protein sequence ID" value="RIE01642"/>
        <property type="gene ID" value="D3H35_25225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="89" mass="9963" checksum="1066423F42D46CEA" modified="2018-12-05" version="1">MLSDIAEIKTVSTQDEITRYNGEPSFVVQVVKNQDANTAEVSDEIKELLTSYQDKGELNVHVIRDQGRRSKSPYPVLFAKACMAHCSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI33</accession>
    <name>A0A398CI33_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">YitT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_15180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02100">
        <property type="protein sequence ID" value="RIE02100"/>
        <property type="gene ID" value="D3H35_15180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006483">
        <property type="entry name" value="Membrane_protein_YitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="229"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="293" mass="31027" checksum="FAA02B7A1063887E" modified="2018-12-05" version="1">MSKNNRRQPRFSPSVRRFASIVSLLLGSFLIAASFNLFLVPNSIASGGVSGISIIVNSVTDVPPAYIQWALNIPVFIAGIFILGRSFGVKTAIGSIVLPLFVLLTAHWTPPTHNPLLAAIYGGLGVGLGLGLVFRGQGSTGGLDTVAQMIRRWTGIRLGLAVALLDGLVIFTAGLLISPEKALYALIGLFVTSKTIDIVQVGLNTSKAAFIVSSEPERVSAAILHDLDRGLTKLQGQGGYTGQSRPVLLVVVGQSEVAKLKALVREVDPDAFVIISDTTEVLGEGFHDPRLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIE7</accession>
    <name>A0A398CIE7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02513">
        <property type="protein sequence ID" value="RIE02513"/>
        <property type="gene ID" value="D3H35_17640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="160" mass="18341" checksum="D0790FE8A27283D8" modified="2018-12-05" version="1">MAGAEAQQWDGVPFFRRLTGANAQQWDGVTFFRRLADAEAQQWDGVPPFQRFAGAEAQRWDGVPFFRRLAGAEAQQWDDVPFFRRLAGAEAQQWDDVPFFRRLAGAEAQQWDGVPFFRRLAGAEAQQWDDVPFFRRLAGAEAQQWDDVPFFRRLAGAEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIR4</accession>
    <name>A0A398CIR4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02270">
        <property type="protein sequence ID" value="RIE02270"/>
        <property type="gene ID" value="D3H35_16215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="159" mass="17014" checksum="6458D938F35C54B6" modified="2018-12-05" version="1">MVEIAGCSWATELADARTEEITGCGWATELADERVVEIAGCSWATELADARTEEITCCGWATELADERMEEITCCGWATELADERVVEIAGCSWATGLADVRMEEITGCGWATGLADERVVEIAGCSWATGLADERVVEIAGCSWAIELAAERVEEIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIX3</accession>
    <name>A0A398CIX3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MBOAT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_14810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02032">
        <property type="protein sequence ID" value="RIE02032"/>
        <property type="gene ID" value="D3H35_14810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024194">
        <property type="entry name" value="Ac/AlaTfrase_AlgI/DltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028362">
        <property type="entry name" value="AlgI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500217">
        <property type="entry name" value="AlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016636">
        <property type="entry name" value="AlgI_DltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE02032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="470" mass="54631" checksum="5D98AFF21B1495A2" modified="2018-12-05" version="1">MFFYSPNFIVFMIALLIPYFIFKRQRLFLLAAANALFYAAHPEGFIVLFLGMCLLTFGIVHLMTRPRWRWLFWVGIIANVLNLVLFKYTLFALDNLKLVGFQTAWTDSFAESIVLPLGISFYTFEFISYLVDVRRGDSKPTRSFFKFWVFVSMFPHLIAGPIMRGDELFPQLDKLPERRISWSDMKYGVYLFTLGIIKKLVIADQLSPIVKEYFDKGSALTGTESWIASYTFSFFIYNDFSAYTDMAIGLGIMLGVRFADNFKSPYLSGDPSEFWRRWHITLSRWIRDYVYIGLGGNRKGAVRTYLNLFGAMLVSGLWHGAMWTYVAWGGIHGLLQVVHRMSLGLNRISWIAAVRKSRLYRVIAVFVFFHIITWTWVFFHAPSIEMALDMTWKMLHAHADNVVAHPTFLLIVGLFAIHVAEFLLRKYEGAVGRAWRFVPFPLRSAVYLAIVLALIYYSKGDKYEFIYFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ23</accession>
    <name>A0A398CJ23_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_11495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03306">
        <property type="protein sequence ID" value="RIE03306"/>
        <property type="gene ID" value="D3H35_11495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007597">
        <property type="entry name" value="CheC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04509">
        <property type="entry name" value="CheC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheC" evidence="2">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="CheC" evidence="2">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="206" mass="21938" checksum="BA55E0460761211A" modified="2018-12-05" version="1">MSLFKKDSELKMDVLREVGNIGAGNAATSLSLLLDKPVDMAVPTVSLLPFEAISNRVGGTEAVVIAIFLRVEGDAPGNMFFILSRVAARRLLQGLLGFNAAEGDHYTELELSALCEIGNILAGSYLSSLADFTGLNMSPTVPSIAVDMAGAILSYGLLQYGTMGDDALLIDTTFVEGQLEAEGQFFLIPDPESFDKLFRSLGVPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ68</accession>
    <name>A0A398CJ68_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartyl-phosphate phosphatase Spo0E family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01269">
        <property type="protein sequence ID" value="RIE01269"/>
        <property type="gene ID" value="D3H35_23050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043937">
        <property type="term" value="P:regulation of sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018540">
        <property type="entry name" value="Spo0E-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037208">
        <property type="entry name" value="Spo0E-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09388">
        <property type="entry name" value="SpoOE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140500">
        <property type="entry name" value="SSF140500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="93" mass="10794" checksum="5EC8FE5CC39A0BD0" modified="2018-12-05" version="1">MDAYMNSDELIHRLQLLQRRLYEMADDLGNLTDPEIIAVSEEADRLIVQLQRIRMNEASSRRAHAFRSETLLSAAQPPEEGREQRPAFFVKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK37</accession>
    <name>A0A398CK37_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketopantoate reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01559">
        <property type="protein sequence ID" value="RIE01559"/>
        <property type="gene ID" value="D3H35_24730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="1">
        <location>
            <begin position="9"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="297" mass="33417" checksum="B5A3ADAB635BE7C7" modified="2018-12-05" version="1">MNTKPYRLLIFGAGVVGSVYALRFAQYGLDVTLLARGKRLEALKRNGLSYNDNGTIKQISVKTIDKLENDDIYDFIFVPVRYDQAESSLTAIKNNKSKTIVTLTNTIGYDSWLEIVGERLLPGFPGAGGDIKEDVLYAQFGSEKHQGTIFGEINGRTTERVKELAQLFESVNLHYEIQKDILAFHISHIALAIVNKHFYTNDGMVDIETARSIKILSKIAADIKQNLHLVEQAGIPVIPPETKAMGELPENDIISRYRQWLSNDFIIDVKLGNHAISQKAEILLLDKMFHELISIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKE9</accession>
    <name>A0A398CKE9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02835">
        <property type="protein sequence ID" value="RIE02835"/>
        <property type="gene ID" value="D3H35_19590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="25"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="128" mass="13765" checksum="7DEF52EF9C01B100" modified="2018-12-05" version="1">MRTLAEGAGIQWDTGKKEASAVKTSIVILTHNQLHITKLCLDSIRAFTGPSYETIVVDNGSSDGTTDFLRSQPDVKAIFNSENKGFAKGCNQGWEVSSGDCVLFLNNDTIVTPGWLEAMLEVLGGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKR2</accession>
    <name>A0A398CKR2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="1 6">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_19940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="1 6"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02890">
        <property type="protein sequence ID" value="RIE02890"/>
        <property type="gene ID" value="D3H35_19940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004439">
        <property type="entry name" value="Isocitrate_DH_NADP_dimer_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43504">
        <property type="entry name" value="PTHR43504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00183">
        <property type="entry name" value="prok_nadp_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="4 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Iso_dh" evidence="7">
        <location>
            <begin position="29"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="430" mass="47150" checksum="6D2A57619D7E220F" modified="2018-12-05" version="1">MQLEKFALPTSGQSITVTEGVLNVPNNPIIPFIEGDGTGRDIWRASQRVLDAAVEKAYKGEKKIAWYEVFAGEKAFNAYGEWLPADTLTAIREYIIAIKGPLTTPIGGGIRSLNVALRQELDLYVCLRPVRYFDGVPSPVKRPELVDMVIFRENTEDIYAGIEYQAESADVKKVLEFLQKEMGVKKIRFPETSGIGIKPVSSEGSKRLVRAAIEYAIKHNRKSVTLVHKGNIMKFTEGAFKNWGYEVAEQEFADQTFTWGQYDAIKAEQGEEAANAAQKAALDSGKVLVKDAIADIALQQVLTRPTDFDVIATLNLNGDYLSDALAAQVGGIGIAPGANINYATGHAIFEATHGTAPKYADKDVVNPGSVILSGVMLFEHLGWQEAADLIYKGIETSINNKTVTYDFARLMEGAKEIKCSEFADQIIANM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKX6</accession>
    <name>A0A398CKX6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Uroporphyrinogen decarboxylase</fullName>
            <shortName evidence="8">UPD</shortName>
            <shortName evidence="8">URO-D</shortName>
            <ecNumber evidence="4 8 9">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemE</name>
        <name evidence="12" type="ORF">D3H35_20880</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8 9">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 8 9"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03045">
        <property type="protein sequence ID" value="RIE03045"/>
        <property type="gene ID" value="D3H35_20880"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8 9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="25"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE03045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="351" mass="39624" checksum="1AFC2C930F6CD71B" modified="2018-12-05" version="1">MSDKDRFLRACRRQSVDRVPVWYMRQAGRYDPDYRKIKEKYSLLEICRQPELAAEVTMMPVKKLGVDAAILYSDIMNPVASIGIDFDIVKDIGPVIHNPVRTVADVDRLKPADIEGDLSHVLTTIEILRKELDVPLITFAGAPFTLASYIVEGRPTKSYINTKTLMYGQPEVWHRLMGKLADLATEYLRAHIRHGAEAVQLFDSWVGSLAPRDFREFVLPHVQNIFAGLKDLDVPKIYFPGVSSGELLPHVTELEADVIGLDWRVPLSEGRRRTSGKFAIQGNLDPYILTAPMEVIKEHARLLIDEGTTEHGYIFNLGHGLYPEASLEKLRELTAYIHEYSGEKLNSGVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL13</accession>
    <name>A0A398CL13_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_17955</name>
        <name evidence="2" type="ORF">D3H35_29275</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000059">
        <property type="protein sequence ID" value="RIE00311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00311">
        <property type="protein sequence ID" value="RIE00311"/>
        <property type="gene ID" value="D3H35_29275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02570">
        <property type="protein sequence ID" value="RIE02570"/>
        <property type="gene ID" value="D3H35_17955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="144" mass="16852" checksum="047E527FD4772DD9" modified="2018-12-05" version="1">MNDILLFTLIITLGINFGIYFRLIAKKRSTINYLFSKLKQILPDKAFESIIIINSSISEDIEILLSHKSGSWIILYNGPDWLFNIKKRKFGERCLLLNEVISDRKVFLFKNSAIFQKKGGKYLHISEVEQFIKYLQYSYSKNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLD6</accession>
    <name>A0A398CLD6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Winged helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_20795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03032">
        <property type="protein sequence ID" value="RIE03032"/>
        <property type="gene ID" value="D3H35_20795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="59"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="367" mass="39385" checksum="3CE50C48519543E5" modified="2018-12-05" version="1">MGREQQIIELIRRDPFISQLEIAEQVGLSRSAVAGHIASLIKKGILLGRAYVMAENGAVLCIGGANLDSKAIGKRTIRPASSNPVDVTQSCGGVARNIAENLAKLSCRTFLLTLVGDDKAGEWLLEETRKAGVDTSPSLMQREMKTGAYTAVLNPDGEMALAFADMAIYDLFSPRLLQEKWPHIAGSQLVIADTNPSADSLAYLIERCRDEKLPLFVDPVSSEKAKKLPERLEGVTAIFPNLEEACELAGVPITDEADAESLAAAIHLRGAEHVFVTLGKNGVAYGGAEGSRSFPVIPTEVVEVTGAGDAFVAGIAYGILQNHSYSEACRFGLAAAHLTLQSSESVSSRFNEEALLRVLEQQHDQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLW3</accession>
    <name>A0A398CLW3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_06975</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04336">
        <property type="protein sequence ID" value="RIE04336"/>
        <property type="gene ID" value="D3H35_06975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="4"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="392" mass="41544" checksum="7D63557B37C98A07" modified="2018-12-05" version="1">MKSKLAIVAIMLLTVFIGFGIIIPVLPQLVSDASPKSAAWHTGGMLTAYSLMSFLLSPVWGSLSERVGRKPVIMIGVLGFSVSFLLFGLSGDNLILMYASRILGGLFSGAVTACIVAYVADITTEENRTKGMAVVGMSIGTGFTFGPLFGGLLSKVSHHAPFFAAAALSFLTFLAALSILTESLTPEKRAEAARLKRVSRWSAFQGPLKALYVLAFFVTFSLAILEGTLQLYGMDRYDVTPLQVAYMFFFCGLVGALVQGGFVRRKIKLGDEAKYIAIGLVISAVGFFLLLTANSWILSTIYLCIFGIGNALIKPCVTSLITQKTTVSQGVASGLSSSMDSLGRIVGPLLGSALLVAAGWLPFVVSGVLSLAALGLLAQFRNMSQRNSQTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM38</accession>
    <name>A0A398CM38_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc metalloprotease</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rseP</name>
        <name evidence="11" type="ORF">D3H35_11570</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03320">
        <property type="protein sequence ID" value="RIE03320"/>
        <property type="gene ID" value="D3H35_11570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00054">
        <property type="entry name" value="TIGR00054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="204"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE03320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="420" mass="46542" checksum="1C4B7C6BBE5BC538" modified="2018-12-05" version="1">MEMIQVTLLTILMFFLLVSLHEFGHYYFARRAGILVREFAIGFGPKLFSVKRGETRFTLRLLPVGGFVRMAGEDPEIVEVAPGQTVAVRVKDDLVTRMYLDRLDERTNVIRGEVKAIDLEKHLYVNLDVDGELQRFDVHRQALVVARGRETQIAPIDRQFGSKTVGQRALSIFAGPVMNFLLAFVLFAVYLLLSGLPKEDSSKVFIYQVSPGMPAAQAGLQKDDWIKSINGVAIGGSTEEVVTAIKASAGKPMQWIVGRDGVDVPISVTPNKDTGLIGINPIPEMRTPTIGETISYSGEMMVVMTQRIFDGFRKIIFGEFKLDDLGGPVKTTQVTLDIAKQGLPQLTSWAAVLSLYLGIFNLLPIPALDGSRLLFLGLEAVRGRPIDPNRESMVHFIGFAMLMLLMVVVTYNDILQLVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMJ8</accession>
    <name>A0A398CMJ8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminoglycoside N(6')-acetyltransferase type 1</fullName>
            <ecNumber evidence="3">2.3.1.82</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Aminoglycoside resistance protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_11845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + kanamycin B = CoA + H(+) + N(6')-acetylkanamycin B</text>
            <dbReference type="Rhea" id="RHEA:16449"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58390"/>
            <dbReference type="ChEBI" id="CHEBI:58549"/>
            <dbReference type="EC" id="2.3.1.82"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.82" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03512">
        <property type="protein sequence ID" value="RIE03512"/>
        <property type="gene ID" value="D3H35_11845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047663">
        <property type="term" value="F:aminoglycoside 6'-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024170">
        <property type="entry name" value="Aminoglycoside_N6-AcTrfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000452">
        <property type="entry name" value="6-N-acetyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="147" mass="16770" checksum="94C4FE453BA3DC2A" modified="2018-12-05" version="1">MRSIIEANEQFIDELVSMALDLWPENDFENLKADFLINLHSEKNKVLLFSIGSEAVAFIHLSIRSDYVEGSEFSPTGYVEGIYVKPDYRRMGISRMLLNAGELWLRDKGCKQIGSDISIDNRISYKFHTSIGFKEAGRVIAFIKSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CML2</accession>
    <name>A0A398CML2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02479">
        <property type="protein sequence ID" value="RIE02479"/>
        <property type="gene ID" value="D3H35_17430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017222120" evidence="1">
        <location>
            <begin position="33"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="568" mass="63581" checksum="C034FD1080687F64" modified="2018-12-05" version="1">MGTLRKSWLLPLAMSVVVIAGCNGNNAGNGNAASSGTPAAGSTATASASATLSESDAAFAKGKYDPPIEISTVIMPKKYTQGDTKDNNVHDRWMLEQFGIKYNDTWYPAGGDQYKQKLQLALTSGEKLPDFVMVPTDPVLTNQLIDSNQFMPIDELFDKYANKIWKDHTAEHPELWYPFTKDGKKWNLPILEYTDNDDTLLWLREDWMEKLNLKAPATIAELENVMDKFKNENPDGLAPKDVYPLAISLKNNTNTWMGGLDWLFGAYGTIEEQWNKDANGNLEYGSINSGAKQALAKLKEWMDKGYINPDSALWDEGKSAEIWTKGNAGVLPGANWVPDWPAPDLLKNVKGAKYKAYPVPAGPDGLIGTKWQNSGVNSSFMINKDAKHPEAIFIYYNYLLDNLANPSTGSKFEYGFAQGYDWDVVDGQPTSNKDKIKDFNNEFPFITGPARIPDLYMKSLVKLAEGNAPATPYEKQLAEFRKPENWYAAKVVMSQLNVRKQNYFTGAATPTMIEKWNLLRQSELETFNKIIYGKLTVDAFDQFVSSWKSNGGEQITKEVNEWFQSVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMM7</accession>
    <name>A0A398CMM7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_10865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03542">
        <property type="protein sequence ID" value="RIE03542"/>
        <property type="gene ID" value="D3H35_10865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04843">
        <property type="entry name" value="Peptidases_S8_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005085">
        <property type="entry name" value="CBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034073">
        <property type="entry name" value="Subtilisin_DY-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03423">
        <property type="entry name" value="CBM_25"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01066">
        <property type="entry name" value="CBM_25"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017438677" description="Fibronectin type-III domain-containing protein" evidence="4">
        <location>
            <begin position="30"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="492"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="762" mass="80735" checksum="37E5B79A921A9321" modified="2018-12-05" version="1">MIRRGLLSFFMFAVAFTSIIAFNNVPVIASGAKETSGDKEAVHSASNEIVVKFKADVNVPYKDGVEREVKAKKDNDLNGILSEYSDLKINRLFKIMDSETKNVDKAKAIFQNYYTITVPEGADSEKLLKKLNNSKLVEEAYSKPIVIEEPSLSSNSTPVLPSNDPNNIYQSYLNAASQGINAPYAWQYEGGDGKGISYVDVERGWALGHEDLTAHSIPLLTGSQIVATSADHGTAVLGVISAVDNTIGNIGLASKAQPMVSSWWRTGEYGNIAEALIVAADALDAGDVILIEIQTTYPGASGYVPIEVYSAEFDAIRYAINHGITVVAAAGNGTVNLDTFQDSSGKYILNRTSPDFKDSGAIMVGAASDTVPHTRMYFSNYGNRIDAYGWGTGVHTLAAASPSATTGYQTSFNGTSSATPIVTAAAIALQGIVKAEYGVTYSPSQLREILRDPVLNTPSSSPSTDKIGYLPNLKNIIDNLPVPVVDTTAPSQPANLISPSKTTTSISLSWDASTDNVGVAHYEILRDSVLVGTSLTTSYTDTGLSAGQAYVYTVKAVDAANNKSLPSSLTISTNSSNIVTVYYKQGYSTPYIHYRPAGGTWTTAPGVAMPASEVPGYNKYTINVGSATGLEAVFNNGSGTWDNNGGSNYFFPVGTSTFIAGTITSGVPVNNTVTVYYKRGFSTPYIHYRPAGGTWTSVPGVAMPTSEFAGYNKYTVSIGSATSLEAVFNNGSGTWDNNGGGNYFFNIGTSTFDSGTITAGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMR2</accession>
    <name>A0A398CMR2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03530">
        <property type="protein sequence ID" value="RIE03530"/>
        <property type="gene ID" value="D3H35_10795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="434" mass="47148" checksum="C072ABFFF088C126" modified="2018-12-05" version="1">MPINEGSFARIIMADVEKRTIPIPGGRYSVQAIVPLAAIKGDTGEVIEHDNVVTFSDGNPHDNHIIVHFNSEKGTLYQIVPAPDPQDHDILVTYFLPVLKDYFQTHIQAIDYALSSINNKRPESGGTILTPKSFVFASAGDGDDGVLSLYIQTNESGNPPGNPSPSFQPGDTAVYPIPQGYTASIILSNRLITQSFLRPQLEACGFSVELSNPVSGGGVSAVLRKDENIIAVGKSGQSFFENHSYQGLQISMQSNPVHMTLQKGGISLEFGGYTLSEWSKSITFTRNSTYGGVYVTIKLHKFPVPLSLSADDVIGSHISVDPSEFTVELKAQGCSFFERMGGCSSSYPAFYDRNLRERIQFPTIALHLPGLDFFNATNLLAPGHNVIGLDTSKGVQTPHDFLVVGNFTSLGQLRKLRAGSPKDHRLAEHPDGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMR7</accession>
    <name>A0A398CMR7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_29715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00214">
        <property type="protein sequence ID" value="RIE00214"/>
        <property type="gene ID" value="D3H35_29715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="199" mass="21709" checksum="4DF65CF2446FE562" modified="2018-12-05" version="1">MRSHPEILRILLIVLVFGLLLMNYNTLLPVYTRSQLNLGEAGYGMLLASMGAGSLAAAVLIALKNQWFQRVYLIPLFPGIIAVLYAVLPIISQYRLLLPIFVIYGFCTTGFITASNTLVLQIGEPKARARIASTYNMMLNGFAPLGNLISGISLHVFGIAASFYWISSLVIGFLAGWVRLSRTKGGDAKALALRSSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMU7</accession>
    <name>A0A398CMU7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_09585</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03795">
        <property type="protein sequence ID" value="RIE03795"/>
        <property type="gene ID" value="D3H35_09585"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="330"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="266"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE03795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="454" mass="49163" checksum="32E16EA9A1887DAF" modified="2018-12-05" version="1">MNVTVIGTGYVGLTTGVSLAFIGHSVTCVDIDERKIENLLAGVMPIHEHGLESLFEAVRPRLHFTVSYAEAVRNAEVVILAIGTPAREDGSPNLSYLHEAVDQVLGSLAGKLTPTLLVNKSTVPVGTGDRLAEKVAARGLSARVSVASNPEFLRQGRALSDTLYPERIVVGGKPEGWRTLRELYLPLLEQKFEEPFDLPRPRGLAPVKFITVTLRSAELGKYAANAYLAMKISFINEMANLCDRVGADVIDIAGIIGTDTRIGGAFLQAGIGYGGSCFPKDTRALHYIADANGYDFKLLSAVIEVNRSQKFTLIDKLRSELIDFRGRKIAVLGLTFKPGTDDLRETPSLPIVEALLAEGAVVAVHDPVALDKARSLLPASVQASSDLEETLQDAEAALLVTEWPIYLALDGHRLRELMKRPLFIDGRNALPPERRIHLDYRGIGTGAAEAALIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMX0</accession>
    <name>A0A398CMX0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02138">
        <property type="protein sequence ID" value="RIE02138"/>
        <property type="gene ID" value="D3H35_15390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_2" evidence="1">
        <location>
            <begin position="21"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="219" mass="24631" checksum="ED43118B9A92420A" modified="2018-12-05" version="1">MTASYEYDVHLPPNAEPGKKYPAIFTLHGKGSNEKNMHGLVEPLSDKFIIVHIRGDLPLGAGYQYYELRGLGNPVRESFDRSVRKLEDFLEEATVKYPIDATNRYLLGFSQGAILSMTLALTLGDRLKGIVALNGYIPEFVKTEYPLRSVENVSVFISHGQYDSVFPLEIGRANAAYFGGRTSRCVFRSYPADHGVSEENQKDFVEWLLQNINTTTDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN19</accession>
    <name>A0A398CN19_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_29290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000059">
        <property type="protein sequence ID" value="RIE00314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00314">
        <property type="protein sequence ID" value="RIE00314"/>
        <property type="gene ID" value="D3H35_29290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="89"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="123"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE00314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="342" mass="38832" checksum="A11C2516544A39C2" modified="2018-12-05" version="1">MTIVNSAVVIILLVVLINKDLVSVGDYIAVTMAVAIIINVISNLIEDYIRMLENLNYSVKAKQMKEQIAEKSIIKSAHGKIPFRFHEQIDISNLSFTYPNIQIESLKNINLTINKGELIAVLGENGSGKTTLVKLLLGLYKVECDSIFYDGIPINQFDENSLYNNTSAVFQDFIKYQTNVRDNIAVGDITYVNNDEKLESALNRVLFDNHFPGGLNTKLGYIDQDSTNLSGGQWQRLALSRVFVKDNPELIIFDEPTSAMDPLSEMRILNEVLRYCKNTTTIMISHRVGIARKADKICVLQQGQIVEFGTHDELIKSKRNYYEMWMSQKEWYEDVEDKIPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN62</accession>
    <name>A0A398CN62_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_04810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04796">
        <property type="protein sequence ID" value="RIE04796"/>
        <property type="gene ID" value="D3H35_04810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="123"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="168" mass="18891" checksum="3A8FFE5802C51CB4" modified="2018-12-05" version="1">MSDAPKPMSHSRSLMTELVFPGDTNHHGTMFGGTLMQYIDKIAAISSIRHCGKAVVTASQDSLDFLSPIKVGEAVELEAVVTWTHRSSMEVYVVVRAENLFTRERRVTVTAFSTFVALDENGKPTPVPSVYPDNDEERKLHESADERYEQRMKRRGQRYSSSTGHETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CND6</accession>
    <name>A0A398CND6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Penicillin-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_19140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transpeptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02759">
        <property type="protein sequence ID" value="RIE02759"/>
        <property type="gene ID" value="D3H35_19140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="6">
        <location>
            <begin position="67"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="5">
        <location>
            <begin position="313"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="660"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="665"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="695" mass="76707" checksum="2589FC8DB8BA7773" modified="2018-12-05" version="1">MGNNKTEEAQKREIRNRRHFSFRLNVFFFATFFVFSLLIVRLAFLQFVEGPKLKEREHDIGTRVVPIPPIRGNIYDSTGTAIAYSTSTQSLYYTLEPGTKEADGKALAVRLFEVFAKYGNKAKNPPNAQEVFEDMDFGGAVHLPFQPRRIKSGLTKEEIAYFAEHQKEFKGVDILEESIRQYSDDQIAVQLVGYMKQMKGATSLDKYKDINTDQKDATLKYLESEEVGFDGIELMYQDELRGRNGLKTYPVNKDSRIVGPMQLTKPVKGENLFLTINKNIQLAAQKAITDQLNKLKHAPKGTTEYEGRNATTGYAVAMEVDTGKVVAMASMPDYNSNLWQGGISSKDYNSIKYFIGNGAIREVQPPYDDDKERAKHPSSLVFLGSTQKPLTILVGLSEKLITPSSSWVDPGYFGFGRKGHETKVRNAKSTPNGRLVPTTAIAKSSNAFMAAMVGNALYLRSPSKAVEIWDGYMKQFGLGVKTGSGLPGEQAGNLNYFKEEKNGSAQSAMIYSSFGQQAQYTVLQLAQYATVLASRGERLKPQFVDHIEDSDGNLVQPFQKELLNTVTFPKQYWQTIEAGMSQVKVQGFEDFPYSFNRKTGTSQQDVAGGKKVENSVFIAYAPADKPKLAVAVVVPEGGYGGWGAAPIARKIFDAYDEQVGLTGTPRKPTPASTVPADEAASQQQGDGANGAAAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNG7</accession>
    <name>A0A398CNG7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04906">
        <property type="protein sequence ID" value="RIE04906"/>
        <property type="gene ID" value="D3H35_04990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="147" mass="16654" checksum="29BF3CF293D49370" modified="2018-12-05" version="1">MQIVRAESAHLDELAPLFDLYRQFYGQSSNEAAAREYLEQRMHAAESVVFIAMENGRGVGFTQLYPTFSSISIKRSLILNDLFVHSDFRRRGIAEKLLHAAKSYAIETGAKALSLSTASDNESAQRLYESFGFEKDTSFFHYDLLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNT9</accession>
    <name>A0A398CNT9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1499 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00574">
        <property type="protein sequence ID" value="RIE00574"/>
        <property type="gene ID" value="D3H35_27970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010865">
        <property type="entry name" value="DUF1499"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07386">
        <property type="entry name" value="DUF1499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="127" mass="14278" checksum="C1D9C3B702D5F12E" modified="2018-12-05" version="1">MLKRMLIGLIRSQEHTGDKAKDPKLKSHYYRLSKDRAWDEIGSILKKMQGYKVLHEVPTIGEIVMEKRTVSGRTMDITVQIVSPTPGTSAVDIYSASRGSLGDLGANYRVIQEIYAVLDRKLAANRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP13</accession>
    <name>A0A398CP13_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PASTA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_06460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transpeptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04255">
        <property type="protein sequence ID" value="RIE04255"/>
        <property type="gene ID" value="D3H35_06460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PASTA" evidence="4">
        <location>
            <begin position="609"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="720"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="738"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="755" mass="81243" checksum="8D0A5BCAD09A2E88" modified="2018-12-05" version="1">MTKRIKLRTLLMGGVLALFFLGLIFRLYWVQVATASEWAAQARKTWMTHKTLTQDRGQITDRNGKVLASDAIAYTVAVGPQRIHDLEEKFPGFQITDQIVAELHTVLGTSEAELRKRIAATKEDGSLRDQSEIRPAGWKVDKAVRDRIDEFAVKLREKTKTKDVGIYFIEESKRYYPNGALASHILGYENKEGKAILGLESKLDNLLKGTAGFIQYEKDRSGTPLPNGEVEVEQPVNGKDVALTLDRDIQFYIEEALREAYAKYNPVSITAIAADPKTMEILGMASLPDFNPNSYGSTKNQAAFKDNGIQSVYEPGSTFKIVTLAAAVQEGLFDPEASYKSGTIRVDKKSRPIKDYNGYGWGDITYLDGLKHSSNVAFVKLGYEKLGTDKFIGYINSFGFGTKTGIELPGELGGSINIDKSIPRDVATATFGQGSVLVTPIQQVAAVAAVANGGNLLKPHIIKSITDPTSGEKQVFEPEKIRQVISAETSKKVAGYLETVVSDQKIGTGKNAYIPGYRIAGKTGTAQKVINGKYAEDKYVVSFIGFAPVEDPQIVLLVIVDQPDIPAAGGGSVAAPIFKQIMGQSLHRLGISPQLPKADAAKEAKTASGPVTVAVPDVQGMTVAQAKASLKRFGVQVVGKGAKVLRQLPEPEVVLPESQPVYLLTTESGAGGAIPDLKGLPLRDALDLCSLLGAACTVQGEGYVAQQKAEQANGKWKVELTLAPPGEQPAEEPEDDTKDSGDGGKTDSKGAKPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP33</accession>
    <name>A0A398CP33_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin-guanine dinucleotide biosynthesis protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mobB</name>
        <name evidence="2" type="ORF">D3H35_20905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03049">
        <property type="protein sequence ID" value="RIE03049"/>
        <property type="gene ID" value="D3H35_20905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004435">
        <property type="entry name" value="MobB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03205">
        <property type="entry name" value="MobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00176">
        <property type="entry name" value="mobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MobB" evidence="1">
        <location>
            <begin position="3"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="220" mass="23520" checksum="45E3285AE3D881BA" modified="2018-12-05" version="1">MRIIQIVGYKNAGKTTLVCEIVRTLSELGLRVGTLKRDAHDFEPDIPGTDTWKHRQAGAAATAITSAARTAWFEERPSELAQLAEGMAARSVEALIVEGFKNAAYPKIVMLRGPEDADLLALPNVVAILTRFPHENAAVKAIAAPEACNVLGASTTRESSEAIEAFAASDAPEPLDFSAAQTSSHSTEFLEKASSQGIPIFTAPDSDYGTVLAFARRFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPJ9</accession>
    <name>A0A398CPJ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04445">
        <property type="protein sequence ID" value="RIE04445"/>
        <property type="gene ID" value="D3H35_07625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="159" mass="17792" checksum="1E5397DE484E3151" modified="2018-12-05" version="1">MRTKDRIPFLQLLVIIAPSRLFLDLKLPWKGAAKNQAARVRTSSPCFFPTDSYPETAHIKGRRSAQRIGHGCNDRIANGSRRAPERVLKGIHKRKADDARRVPMACARKALGCGHQVDRPLRTTRAGSWASNQVGGLPDGTRLSFVFRSRAHVGRIERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPM9</accession>
    <name>A0A398CPM9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00914">
        <property type="protein sequence ID" value="RIE00914"/>
        <property type="gene ID" value="D3H35_25425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="490" mass="54844" checksum="1D8799EF592A538A" modified="2018-12-05" version="1">MLYVNFHLIMLPECKISFKTAKRWESPLTKQSPKKVVSSLLLTLVIVLLLSACSSKSGTNNAASPSTTGELPASSGNTEKVEINWVMAADPDKKAWQDSVIASFEASHPNIKVHLENIPYDQFDQKLTTMISSGNAPDVWNPNQADSGFATYMSMGAIKDLTPYIEKGVPELETMDKDLLNIYRIDGKYYGIPLVSNATYLFYNKDLFDAANIPYPTTDWDDKTWTYDKMLEIAQKLTHDVGDIRKQVFGFSSNLTANAMAWSFGGDFFKPEAYTTGVMGEPDLSNPKNVEALQYNLDLIEKYKVSPDQQTVAASAQLGDVFMTGKVGMFINGGWGLGAYEKADFKWGVAAVPYKDGRKVTLYVDPWSISASSKHPDEAWEFVRHLANPAEGGGAYKYMNEVGRTPADSSLFELWYEKISKQINMDKNDFKQVHEGSIKYGREAENHLIVKFNTILETMNQTMSSVWNGRKTLDTGLKEMDQNLRSLNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPS3</accession>
    <name>A0A398CPS3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_05420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyltransferase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04535">
        <property type="protein sequence ID" value="RIE04535"/>
        <property type="gene ID" value="D3H35_05420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="13"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="398" mass="46322" checksum="64CE131FAA4C8C6D" modified="2018-12-05" version="1">MATIPKDENGKIPELQLVRAMAIICVLSVHASASATVAMKESGYYYFYNFINIFMKIGTPTFILLSSFVLFYSYYSRPIDIKLIAGFYKKRLLYIMIPYVVFSAVYFLLTQRYGHHPILSRESLLLFGQKLIAGKAFAHLYFVFISIQFYLLFPLLLAAVQRWKAIARWLVPLGFAVQWGFVLLNKYAWQVPDKGSWSLSYFSFFMLGAAMGIYYPKIKNGLLNRNNQKRKVRAYRIGWSVIWSVWLMLSMAHVTIYFNARSYGTRYDSLWYELLWNFQCVFAALALFQAAFFIQKYWPGFVSRPLHRLGQYSFGIYLIHLLFLLFYDRYMPGFGISWPSHFRYLGSWLVMLGASWATVELAARFVPFAWIGFGNLPRSAEASRHFPQTPTIQPHSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ41</accession>
    <name>A0A398CQ41_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heptaprenyl diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_03910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04645">
        <property type="protein sequence ID" value="RIE04645"/>
        <property type="gene ID" value="D3H35_03910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009920">
        <property type="entry name" value="HEPPP_synth_su1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07307">
        <property type="entry name" value="HEPPP_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="263" mass="30326" checksum="AFC2D1461E2CC3A4" modified="2018-12-05" version="1">MSERRCGARYQVRRLEMTRNRIAQLAQKYMYHDMIGKHTELPDFPEARIRLLYSVLGHQPAASLNKELMALVASLVQMGLDTHDTVRNENAPSGEKSGILSMRAQQLKVLAGDFFSARFYQLLSQAGQIDAVRRMSEAVCEVNRVKMIFYTKMKQLKLNAEEYVQLSSEIRSGLFVAFTAFMQGLCERLWPEIVERFSRCEVLLKEIRQVEQTSDLESSWGVWHIMQEGSEEDRLALAQRQEDSSFIRHLLDKYHVPRSSAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ56</accession>
    <name>A0A398CQ56_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-dehydroquinate synthase</fullName>
            <shortName evidence="8">DHQS</shortName>
            <ecNumber evidence="8">4.2.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroB</name>
        <name evidence="10" type="ORF">D3H35_03955</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04653">
        <property type="protein sequence ID" value="RIE04653"/>
        <property type="gene ID" value="D3H35_03955"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00110">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="9">
        <location>
            <begin position="75"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="78"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="112"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="136"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="175"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="368" mass="39497" checksum="C4C0404D23709C4E" modified="2018-12-05" version="1">MAGGIKELTVDLGERSYPILIGPGLLARVGSLFAERGFAVKSPILLITDASVEDLYAGTVEQSLRDKGYTVARAVVPSGETSKSLTVFDDMITACLEAGLDRRSTVIALGGGVVGDLAGFVAATYMRGVRFVQIPTTILAHDSSVGGKVAVNHRLAKNIIGAFYQPEFVMYDLDTLLTLPIREVKAGLSEVVKHGLIWNADFVAWCDDNVDKLLALDPEALGYALYEGCKVKAIVVSRDERENDLRAILNLGHTIGHALEAVAGYGELLHGEAIAIGMVGSARLAGKFGYDPSIEAVTEALFRKIGSPVRIPGHLDVDQIMAAMQHDKKFMEGQMVFVVPTAIGAVEIRHDVPTAWVREIVEGLREGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ92</accession>
    <name>A0A398CQ92_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04695">
        <property type="protein sequence ID" value="RIE04695"/>
        <property type="gene ID" value="D3H35_04200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="23"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="270" mass="30184" checksum="CA4D9AA9F87140EF" modified="2018-12-05" version="1">MGYYVQVEQGVKLFVEDIGAGRPILFVHGWPVNHNMFEYQTTHLPKYGFRCILIDLRGYGKSDKPWTGYSYDRLADDIRVVIDTLGLDNVRLVGFSVGGAIVVRYMGRHRGHKIAQLLLLAAAAPSLTQRPGYPIGQPRANIDKIIAGTYADRPGVLAQFGEDCFASPVSTPFRQWFQSLGLEAANHATVAVMESLRDEFVGQDFPFIRVPTSIFHGVLDKVCLYPLALAQHAGIQGSVLHRFEKSGHGIFYDELELFNQRFFKALNDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ98</accession>
    <name>A0A398CQ98_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cof-type HAD-IIB family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01154">
        <property type="protein sequence ID" value="RIE01154"/>
        <property type="gene ID" value="D3H35_22365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="259" mass="28814" checksum="5944265E70A3831F" modified="2018-12-05" version="1">MKFSVVVLDLDGTYLNSAKQVSERNLAAVLACFDEGMRIVIATARPPRAVKEFLPEELHNIAAFVYYNGAQVICRHTGTEWHESIPASLTAEIIDFCLNRNPDAELTMEYRDEWFGLRELDYSVVMNVKANPVVKSLEELRQYEATKLLLSGEIELQPLYEAFAHRVNLIATDNNQLIQIMPLRASKEQAVAKLCEIYGTGADSVIVFGDDHNDIGLFRSSGYSVAMGNAISELKEIADEITASNDRDGVALILEKVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQF2</accession>
    <name>A0A398CQF2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA_edit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01224">
        <property type="protein sequence ID" value="RIE01224"/>
        <property type="gene ID" value="D3H35_22790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="30"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="149" mass="16563" checksum="1905C39193FF4479" modified="2018-12-05" version="1">MFTLDELQTYLKDSNSDFEIIAHETPIISTQDAAKYFDIEKAAPTLILQTEQGLIAFIVSSQRGRIDFKALGEELGYSKVKMADKSKVLEVIGYHPGAVPFIGHGLPCIFDNRLLVLDYIYGGSGDELHTLKIAPSDVTRLNNVIKFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQF9</accession>
    <name>A0A398CQF9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01661">
        <property type="protein sequence ID" value="RIE01661"/>
        <property type="gene ID" value="D3H35_22325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="87" mass="10234" checksum="F22F508D0C9855FE" modified="2018-12-05" version="1">MKKYVNAKQILPQHLIEEIQKYVEGAHLYIPQKGRKSWGSANGSREQLEKRNMEIQFLFRQQGVSIIELAARFGLSEERIRSILYDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQL8</accession>
    <name>A0A398CQL8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_21210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03098">
        <property type="protein sequence ID" value="RIE03098"/>
        <property type="gene ID" value="D3H35_21210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="2"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="229" mass="25973" checksum="7F792F25C0DA797E" modified="2018-12-05" version="1">MSYIVYDLEMTVRRKKGQIAEIIEIGAVKVDIIEGLPQVVDTFQSFVKPVIVTQLTSDTTTFTGITQDDVNGAGTLAQIVRDFAAWMGPDEYYLCAWGPDDQRQLVQECRQHGIPTDWIVNHNNLQKMLSKTFKLEKHQQMGLKPALEMLEIPFSGSHHRALDDAINTAQILVKLFDRVQFRRNKVSDESKIETEIVYKTDHFENLPFASLAGLAGLIPNDKKLPQQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQM7</accession>
    <name>A0A398CQM7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_21270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03108">
        <property type="protein sequence ID" value="RIE03108"/>
        <property type="gene ID" value="D3H35_21270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="492" mass="53670" checksum="1B743EFFBE08BCB2" modified="2018-12-05" version="1">MYIVSLIFRLANACEFKYEIIQFFMGGQNVKQKASLLSLVVVMIMGFGLTACAGTNNTGSNSNASPGASSSSSPGSSASPNEKPFAGKKVSMLLSQNAFTEEFRDVIIPQFKAKTGIDVVVDVLPESGYDTKLIMSLAGGTGEYDVVMSGAKNWSQMVSSEWIIPLDDYYNNSEDEYKNGFSQSLMNTLKVNGNTYAIPNNIGSNLLYYNKEMFEAAGIDPNDPPESLDEMIEYAKKLNKPEQDKYGFVTRGTREGNANSFSWIMMWFLNGGRWVGVEGRPDYAVLDLPEAIKTMDDFKTLTQYSPSGIASYGFQEAQLAMQQGKAAMWIDVASLGPSLEDPAVSSVAGKIGYHVLKGKGEDFTVGSVWAYSITKTAKNKDAAWELIKYITGKEVSLQQILSGTNGSPARADVLELEEVKKVFNEDFIDALKVATSYSNPHYTPLIAEGSEIRSALSVAISEVITGQKESEKAMKEANEQTLAILKKGGYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQZ3</accession>
    <name>A0A398CQZ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4Fe-4S ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_16055</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02247">
        <property type="protein sequence ID" value="RIE02247"/>
        <property type="gene ID" value="D3H35_16055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012206">
        <property type="entry name" value="Fd_FixX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43082">
        <property type="entry name" value="PTHR43082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036548">
        <property type="entry name" value="Fdx_FixX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="111" mass="12226" checksum="E4CB8F1F564328F0" modified="2018-12-05" version="1">MSDDTNPSATAASGSAAAKATTIEEKQYLLRFNADTQSHLHVLSADVCLDHCPDKLCTIFCPAEVYKWEDIRMHVGYEGCHECGSCRIGCPHENIKWVYPKGGHGIVFRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR32</accession>
    <name>A0A398CR32_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tripartite tricarboxylate transporter TctB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000038">
        <property type="protein sequence ID" value="RIE03248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03248">
        <property type="protein sequence ID" value="RIE03248"/>
        <property type="gene ID" value="D3H35_12800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009936">
        <property type="entry name" value="DUF1468"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07331">
        <property type="entry name" value="TctB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="161" mass="17257" checksum="F4FAE56DAA9B23B3" modified="2018-12-05" version="1">MIPKLAILRRSGLLTLALGVFFLYQSLKLELGSWNEPGPGLWPLLLSLLVLTASFVLLIGNSEGGAGSEKKPFAALLRDSRLPLAAIASLVLFIVLSRYAGLTLAGGIMLLAWLRLLGKEKWTTSIVVAAGLTALCHVLFAVALQVPLPEDWLLALWSAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR43</accession>
    <name>A0A398CR43_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplW</name>
        <name evidence="10" type="ORF">D3H35_02250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE04992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04992">
        <property type="protein sequence ID" value="RIE04992"/>
        <property type="gene ID" value="D3H35_02250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="97" mass="11253" checksum="535E31824D7161E2" modified="2018-12-05" version="1">MKDPRDLIKRPVITERTSEFIDQRKYVFEVELKANKTAIKQAIEQIFKVKVVNVNTLRVPAKPKRYGRHSGYTSEWKKAIVTLSADSKPLEFFEASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRE3</accession>
    <name>A0A398CRE3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Phosphoenolpyruvate carboxylase</fullName>
            <shortName evidence="11">PEPC</shortName>
            <shortName evidence="11">PEPCase</shortName>
            <ecNumber evidence="5 11">4.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ppc</name>
        <name evidence="14" type="ORF">D3H35_02650</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11">Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>oxaloacetate + phosphate = hydrogencarbonate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:28370"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the PEPCase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.31" evidence="5 11"/>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05135">
        <property type="protein sequence ID" value="RIE05135"/>
        <property type="gene ID" value="D3H35_02650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008964">
        <property type="term" value="F:phosphoenolpyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00595">
        <property type="entry name" value="PEPcase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021135">
        <property type="entry name" value="PEP_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022805">
        <property type="entry name" value="PEP_COase_bac/pln-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018129">
        <property type="entry name" value="PEP_COase_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033129">
        <property type="entry name" value="PEPCASE_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523">
        <property type="entry name" value="PTHR30523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00311">
        <property type="entry name" value="PEPcase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00150">
        <property type="entry name" value="PEPCARBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00781">
        <property type="entry name" value="PEPCASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00393">
        <property type="entry name" value="PEPCASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="9 11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 13">
        <location>
            <position position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE05135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="932" mass="107223" checksum="A70A30549AA3C1C1" modified="2018-12-05" version="1">MTELATATAGRSSSNHLLRRDVRFLGNILGEVLVHQGGRELLDQVEKIREMSKALRAEFLPELYAEFVKNVKSMEPEIRHRVIRAFAIYFQLVNIAEQNHRIRRKRDYERSAGEAVQPGSIENVVQSLKEKNVPLEELRGMIGDISLELVMTAHPTEATRRAVLDIHKRIADEMMELDNPTLTYREREKLRDKLLNEVLTLWQTDELRDRKPTVIDEVRNGMYFFHETLFEVLPEVYEELERCLTKHYPEEAWHVPTYLRFGSWIGGDRDGNPSVTAAITWQTLTMQRNLVIYKYEQNIRSLMRQMSFSTSIADISPELTESIKLDRENIELRIVDPWTNEKEPYRIKMTYMLQKLSNMREEEFKGTKQRYHEVSELLADLGVIDRSLRHHYADYVADTLLKKLIRQVELFGFHLAALDVRQHSKEHENAMTEVLAKAGVIENYSDLTEEAKLELLHHLLSDVRPLLYETAELTDTTKECLDVYKTIYRAQKEFGQGCITSYLISMTQSASDFLEVLVFAKEAGLFRRSDNGAYFSTLQAVPLFETIDDLHAAPGIMKTLFELPIYRECLSAMGNMHEIMLGYSDSNKDGGMVTANWELRLALKELTETANEYNVKLKFFHGRGGALGRGGMPLNRSIMAQPPNTVGAGIKITEQGEVLSSRYSLKGIAYRSLEQATGALVNAAYLARHPSEENGSEARWEEIMTVISETAQTKYQDLIFRDPDFMTFFKESTPLPEVGELNIGSRPSKRKNSERFEDLRAIPWVFSWTQSRYLLPAWYAAGTAFHGYVAGDKERLETLRTMYKEYSFFSSLIDNLQMALAKADLLIAREYSEMIKDDTIRTRIFTQIEEEYARTKEMILAITGQEEILDNVPVIQESIRLRNPYVDPLSYMQVQLLTELRQLRADDQDDAVILREVLLTINGIAAGLRNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRG1</accession>
    <name>A0A398CRG1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglutaminase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02417">
        <property type="protein sequence ID" value="RIE02417"/>
        <property type="gene ID" value="D3H35_17065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="30"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="232" mass="27106" checksum="9456B71A322BDCD7" modified="2018-12-05" version="1">MRAYLEETELLNYSHPLIRQVILSRKWNRMPRKEQILGIYNYVRDEILFGYNRADDIPASEVFQNGYGQCNTKGVLFMALLRAMGVPCRVHGFAIDKKLQKGAMKGWYYQLSPGEIVHSWVEVHYEGKWLNIEGFILDIPYLTKLQQKFGQCTGSFFGYGVATDNFQNPDIYWNENDTYVQKEGIVRDFGIYDSPDAFFSVHQQGLSPLRKTIYSRVVRHLMNRNVNRIRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRM7</accession>
    <name>A0A398CRM7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_12300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03438">
        <property type="protein sequence ID" value="RIE03438"/>
        <property type="gene ID" value="D3H35_12300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="139" mass="16065" checksum="ECF91EFE9D91CF68" modified="2018-12-05" version="1">MSVESVLRQFKEKGLRMTPQRAHVTKLLYEMGHPTADQLYCRLIERYPYVSHATVYNTLKLLKEHGLVTELTHSDRVSHYELAQAEHWHFTCKSCKEIFDMEAGEPGLPRVFSSLQEGFVVDGYRIEIYGTCPNCSKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS92</accession>
    <name>A0A398CS92_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000002">
        <property type="protein sequence ID" value="RIE05475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05475">
        <property type="protein sequence ID" value="RIE05475"/>
        <property type="gene ID" value="D3H35_00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="78" mass="8503" checksum="2B92EA320A6ED3D9" modified="2018-12-05" version="1">MLKPQSEADLENLTVMTDAGPKPASSVAEWVKEELPTKFFHKDGKSYVRVAATVEPSQLSIVGADIKKAMNDVKTPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSF7</accession>
    <name>A0A398CSF7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_13970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01884">
        <property type="protein sequence ID" value="RIE01884"/>
        <property type="gene ID" value="D3H35_13970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="64" mass="7359" checksum="82F14E239EFD6EBE" modified="2018-12-05" version="1">MEWTWESSVARSMKTERIGRWRLGENGLTFVRNPIVDRESHGIVPSARIDRGEVKTFLKNLGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSK4</accession>
    <name>A0A398CSK4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_06325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04229">
        <property type="protein sequence ID" value="RIE04229"/>
        <property type="gene ID" value="D3H35_06325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="317" mass="34701" checksum="A1B53CD1CA7BCC32" modified="2018-12-05" version="1">MALSNRYIGFGLQIWSELTLPELVKIRQGEEPDVRIEIGDLKRKWEECGSPMTYFAVKDGEVFFNIPNAALFRIDNGNRITVSPEAGADEAFIRLYLLGLCMSALLLQRGVLPLHGSAVVVDGLAFAFLGNSGSGKSTLAAAFTRCGFRLLSDDVIAISASCENNERSTPVAIPSFPYQKLWNASLEPLGLSGSALSPIYGETTKYAVPASNVYSAAAVPLSGLFELLPSEDAQKVDIAPVSRLERFPLLGHHTFRNFLVPLLDLGDWHFRVSASIAAKTDIYRLRRPTNRFALNEMVDRIVETARVFNAGGMGRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT35</accession>
    <name>A0A398CT35_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">8-amino-7-ketopelargonate synthase</fullName>
            <ecNumber evidence="9">2.3.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">bioF</name>
        <name evidence="11" type="ORF">D3H35_20510</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42288"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9955"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78846"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="EC" id="2.3.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cofactor biosynthesis; biotin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.47" evidence="9"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02987">
        <property type="protein sequence ID" value="RIE02987"/>
        <property type="gene ID" value="D3H35_20510"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008710">
        <property type="term" value="F:8-amino-7-oxononanoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004723">
        <property type="entry name" value="AONS_Archaea/Proteobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00858">
        <property type="entry name" value="bioF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="6 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="10">
        <location>
            <begin position="40"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604723-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE02987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="392" mass="42744" checksum="8AC62D0C3E63EFD4" modified="2018-12-05" version="1">MKWMEDELALLAGASLERSLRDTVPVPGRAGYAVRGERRLLNLSSNDYLGLSQHPAILEAIRQSLPAEGGGAGASRLVTGNRSPYSRLEEALAAWQNREAALVFANGYMANCGVIQAVVGRGDAVFSDRLNHASIVDGIVLSRAEHARYRHNDMEHLRQLLHKHRDKRRKLIVTDAVFSMDGDRAPLRELVELKREYGANLMVDEAHSGGIYGERGEGLCSELGLGDEVDIHMGTFSKSFGVYGAYVCGSRTLIRWLVNKARPLIYSTALPPSILAGISTALELVQTERWRRDKLVASCLLFRSSLSAAGFHVGHGDSPIVPVIIGDNDRALRFSEALEENGIAAVAIRPPTVPDGTARIRFSLSADHSEAELTDAVSVICRLGLEFGVLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT55</accession>
    <name>A0A398CT55_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_20640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03007">
        <property type="protein sequence ID" value="RIE03007"/>
        <property type="gene ID" value="D3H35_20640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="145" mass="14664" checksum="73841F206CFC970B" modified="2018-12-05" version="1">MCVKLNSHASAGYASGTMCAKLNSDASAGYASGMRVWKLNSDASAGYANGTMCAKLNSDASAGYTSGTMCAKLNSDASAGYASGMRVWKLNSDASAGYANGTMCAKLNSDASAGYASGMRVWKLNSDASAGYANGTMCAKLNSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT56</accession>
    <name>A0A398CT56_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02144">
        <property type="protein sequence ID" value="RIE02144"/>
        <property type="gene ID" value="D3H35_15435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="73" mass="8218" checksum="490A3CA560C2594C" modified="2018-12-05" version="1">MTCKSIEAYVNITLYVAIIRRQPHSYYCPKRAAFNHAFHTNFCRIRTSSAGDTKPSEKREGGGDCPLPSFLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTM2</accession>
    <name>A0A398CTM2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_16465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02314">
        <property type="protein sequence ID" value="RIE02314"/>
        <property type="gene ID" value="D3H35_16465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="139"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="358" mass="39140" checksum="7E62FA45624B2F85" modified="2018-12-05" version="1">MAQATKIRLGLIGAGNIGNVHLQEFGKLTELCEFVAVTDAYLPLAEQRASEYGIPVVANTPEELILRDDVDAVIVAVPNMAHAPLTIFALENGKHVLVEKPMGLDSNAAKEIVRAQQRTGKTVMVAHQMRWESLPLQVKGKIEAGELGRIYTAKTGWYRRKGIPGWGTWFTQQSQSGGGPLIDIGVHMLDLAFFLMGEPKPVSVYGSTYAEFGPKKKGIGDWGKPDWNGVYDVEDLATAIIKMDDGSSLTLEVSWAVHMDTDSAPFLHLMGSEGGAFLKGDQGKYLTERDNATVDEALVTPVEDEGARVRLSRHFLECVREGKEPWTSAVTGLRSNLIIDAIYESSRTGGEVKLDWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTS4</accession>
    <name>A0A398CTS4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_16755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02364">
        <property type="protein sequence ID" value="RIE02364"/>
        <property type="gene ID" value="D3H35_16755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017197240" evidence="2">
        <location>
            <begin position="22"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="169" mass="17884" checksum="05773B9D82789F6A" modified="2018-12-05" version="1">MSVFIAVFLCCLFLFSAISKAFDWRRFGESVAELGLARINVKLAVIVVPAAEAAVAALLPWPGTRTAGIVLLLGLLISFAWAAWKAKGQNIECHCFGKAVSENFGALTFVRIGVCGALSIGLLAYPSQRDLFSLGAAEVLYMVLTSCGILAAYVLLSAIAGHKKTGMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTT8</accession>
    <name>A0A398CTT8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent protease subunit HslV</fullName>
            <ecNumber evidence="5">3.4.25.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">hslV</name>
        <name evidence="6" type="ORF">D3H35_11335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP-dependent cleavage of peptide bonds with broad specificity.</text>
            <dbReference type="EC" id="3.4.25.2"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Allosterically activated by HslU binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase T1B family. HslV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.2" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03277">
        <property type="protein sequence ID" value="RIE03277"/>
        <property type="gene ID" value="D3H35_11335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01913">
        <property type="entry name" value="protease_HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00248">
        <property type="entry name" value="HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022281">
        <property type="entry name" value="ATP-dep_Prtase_HsIV_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="PTHR32194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039093">
        <property type="entry name" value="HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03692">
        <property type="entry name" value="ATP_dep_HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0888">Threonine protease</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="7"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="179" mass="19248" checksum="98591B6F9ABB2383" modified="2018-12-05" version="1">MNEFHATTICAVRHNGKAAIAGDGQVTFGQSMVMKHTAKKVRRLYRGQVVAGFAGSVADAITLFEKFEGKLEEHHGNLQRAAVELAKDWRSDRVLRRLEAMLIVVDATGMLLLSGNGEVIEPDDGVLAIGSGGSFALAAARALKKHAPNLEANEMARAALETAAEICVFTNHNIIVEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTW8</accession>
    <name>A0A398CTW8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trehalose utilization protein ThuA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02761">
        <property type="protein sequence ID" value="RIE02761"/>
        <property type="gene ID" value="D3H35_19155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009381">
        <property type="entry name" value="Trehalose_catabolism_ThuA_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030013">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThuA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="240" mass="27373" checksum="7BE6F8DE8A7B698B" modified="2018-12-05" version="1">MVRVTVWNEFRHEQEHEEVRSVYPEGIHAVIAAGLNEAGEGFAVRTATLPEPEHGLTEDVLNDTDVLIWWGHMAHGDVDDAIVDRVHERVMNGMGLIVLHSGHFSKIFKKLMGTGCDLKWREAKEKERIWTVDPSHPIAEGIPEYFELKPEEMYGEHFDIPAPDELIFVSWFEGGEVFRSGCTFRRGQGKIFYFRPGHETYPTYYHPLVRKVIANGAKWAAPTANAKPVRGHHQPLEPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTY3</accession>
    <name>A0A398CTY3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4358 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04729">
        <property type="protein sequence ID" value="RIE04729"/>
        <property type="gene ID" value="D3H35_04395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025648">
        <property type="entry name" value="DUF4358"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14270">
        <property type="entry name" value="DUF4358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017190137" evidence="1">
        <location>
            <begin position="25"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="172" mass="19110" checksum="4C5C9A6D0F403D0C" modified="2018-12-05" version="1">MKKRYSLLLLIVVIGLLVSACSNKTNNNTDSDTAGKQPTYESSLSAKEMTDKLLAQVEQPQLMDIDAASVKDQFHLDASLLADYSIKMPLMNVKSNEIAILKINDIKDIPAVETALKQRAADVQKQFETYLPDQYENAQNFKIIVKGVYVLYVISESADQLAAAFDELFAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTZ5</accession>
    <name>A0A398CTZ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02434">
        <property type="protein sequence ID" value="RIE02434"/>
        <property type="gene ID" value="D3H35_17165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="413" mass="44332" checksum="F4C1E8CAEA1EDBA3" modified="2018-12-05" version="1">MSIQQDLIFRMLPSQFRKSDESSLIYQLCWALGFPLGGLDRLGRRVLKSRYLDSVSDIADAARLALPFGEPPWPQDTIDEYRERLQSYIPLFLQGALSAERIILLTALAYGGTADTIALPNPYNLPDRPANEANVTTGRITAVVRDGSGKPSVVAFTAAVIERPEQARQQYTVAPTAEQSTWVIDGDGSFSPVIDITAGANPLVAPILAQRDTGFLLLVNRIIPPGGTIRIDTAASAVRDFGGSPSSDGPVLMPDGTAPPLLCGTGAILDDERSNKLSESDGTPLRLVHWSAAKIESAPLLPKGTSSWRLLQVARSNAESLAADVAPNAAEKGILVADLTTSFPDPAGCPKSVTFRWDIAPIPASFTVAYRADHQSSWYPEAPLAPNVSWLRNQINRLKPAGVAYLDPASVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU05</accession>
    <name>A0A398CU05_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="3">DERA</shortName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="3">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">deoC</name>
        <name evidence="5" type="ORF">D3H35_06090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04188">
        <property type="protein sequence ID" value="RIE04188"/>
        <property type="gene ID" value="D3H35_06090"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="263" mass="27426" checksum="A9BC547E59CF1EF0" modified="2018-12-05" version="1">MPEAVNTAKRITPSDARETEIENCPNDDPSILEYRFPIWVPGTRTAAFIDYTFLRPEANARDIAVICAEAKEYGFHSVCVSSGWVRLTREKLSGSPVKVSAVVGFPLGAVATRSKAFEAAAALEDGASEISMVISIGKLIDGEHEAVERDIGAVVQAVQGGALIKVILETASLTDGQKAEGCRIAEAAGADFVQTSTGFGRGGATVADIRLMRAAVSPMMGIKASGGIRNLASAQALLSAGAQRIGSSSGVEIVNRLESSTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUA9</accession>
    <name>A0A398CUA9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrE</name>
        <name evidence="6" type="ORF">D3H35_06660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04288">
        <property type="protein sequence ID" value="RIE04288"/>
        <property type="gene ID" value="D3H35_06660"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="57"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="127"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="214" mass="23148" checksum="73ACDFE39A89F3BA" modified="2018-12-05" version="1">MTTNLDQLPAVIAGNLLEIGAVSLRPQQPFTWTSGMISPIYCDNRLTMSFPSVRETIAEGFAAIIREQFPDCEAVAGIATGGIPHAAWVAQKLNLPMLYVRDKAKGHGKTNQIEGHYTSGQKVVLIEDLISTGGSSLKAAVAVREAGCEVQGVIAIFTYQFAHAIEAFQAESIPLATLSNYSALVQEALSRGAIREEDVAQLQSWRENPQEYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUB6</accession>
    <name>A0A398CUB6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02861">
        <property type="protein sequence ID" value="RIE02861"/>
        <property type="gene ID" value="D3H35_19735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="391" mass="42339" checksum="0312E0A3AF152D44" modified="2018-12-05" version="1">MKRKSNLQRSRSSVVRPRSAGKVGRRPRKALQGAKNKAQRRSGRRYSRNRKSSRSLGATLLSPPPAPVVLSSVYFERGVTAGAEWRSSNPPDPFSAGKIKETIFDGWNRIVREHSHSAHSGASIRAGDGVSYAKGFFRGAGIGEFPVAPVALKGKAVAVVCTAGEEYSLYSVMEQLTALPLDEIVVILYGPADGKFYRAKGYANTIVVFMPELTDADVGRALGANLADAETVLLVDGNAPVPAERLAEMLEMTDGRADITLADTPDNDSTFIRRNAVLRFQEFLNATLDRPELRTNSFSQLPLALSRHALNTLGAAVLTVPTVAHAMALLKGLKIGLVRVSDVSPVQRENALAKSAGDHMEAWREAMSVRGGRLEFADTYRNRSVLGGTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUK7</accession>
    <name>A0A398CUK7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-layer homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_06925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04328">
        <property type="protein sequence ID" value="RIE04328"/>
        <property type="gene ID" value="D3H35_06925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017349662" evidence="2">
        <location>
            <begin position="29"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="24"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="154"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="330" mass="35817" checksum="7343B5C17BCB0871" modified="2018-12-05" version="1">MNTWKRKSITLTLLVSLLCLTLSGSVYAFNDVKGEPESAAITKLEQRGILKGNGSGLFHPKQTLNAASAVSLIVRGLELNIDNLRFFKEPLASDYYTKVNDKAWYAGSFIIAQFNGLGLPKDIDPNAIVTREQFAKWLFGALSTKGDYAWIEIFLEVADADAVTDGYMDSIQKLLIAKIAVLDGKQAFRPKQPITRAEAAGMVARTIDFINDKKNTPVQPPVSYDVKLASEKVGTEAQRVTLTTTVGHPGYGFEISSVDFRDGKAYVNYRIVQPDPDRMYPQVLTEVKATTIISSDLTPVLGSDESGYSVSGSQPSDGSGAAGSTGFPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUW1</accession>
    <name>A0A398CUW1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PHP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_07260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04378">
        <property type="protein sequence ID" value="RIE04378"/>
        <property type="gene ID" value="D3H35_07260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="2">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="282" mass="30104" checksum="2201811217328A75" modified="2018-12-05" version="1">MNRADLHTHTTASDGKQSPTDNVRLAAEAGLAAVAITDHDTVAGISEALDAGARYGIVVVPGVEISTAENGTDIHILGYGISWRDPDLLGRLEELRSVRGKRNERIVARLNELGMPITMEEVAAEAQASPRGDGSIGRPHIADVLVRRGFAADMRDAFDRYLGEGGAAHIVPPRIAPEEAIRWIHEASGVAVVAHPGLYRKDDLVERLLEFGGADGIEAFHSDHDEVAEHRYSRMAAKAGKLATGGSDFHGTRQGVVFHGPIGSRTVDASIVPRLLGERAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVT7</accession>
    <name>A0A398CVT7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit A</fullName>
            <ecNumber evidence="6">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NADH dehydrogenase I subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NDH-1 subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nuoA</name>
        <name evidence="8" type="ORF">D3H35_14625</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cell membrane</location>
            <topology evidence="6 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03134">
        <property type="protein sequence ID" value="RIE03134"/>
        <property type="gene ID" value="D3H35_14625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01394">
        <property type="entry name" value="NDH1_NuoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023043">
        <property type="entry name" value="NAD(P)H_OxRDtase_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="PTHR11058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="6 7" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="153" mass="17270" checksum="5B242298E39FAFBE" modified="2018-12-05" version="1">MDLNGSICYNCEGNLTGSACRTAYDLGGEEVEKYVNSYVIVTVFLVLGILFPIFVLSLGKLLRPHKPAPGKEMTYESGNVPVGDSQIRFNVRYYLYALMFVVFDVETVFLYPWAVAYKQMGLFALVEMVIFAGLLLIGLLYAWKKKVLQWNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVW0</accession>
    <name>A0A398CVW0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMN reductase (NADPH)</fullName>
            <ecNumber evidence="2">1.5.1.38</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ssuE</name>
        <name evidence="2" type="ORF">D3H35_08665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.38" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04017">
        <property type="protein sequence ID" value="RIE04017"/>
        <property type="gene ID" value="D3H35_08665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052873">
        <property type="term" value="F:FMN reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008752">
        <property type="term" value="F:FMN reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046306">
        <property type="term" value="P:alkanesulfonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020048">
        <property type="entry name" value="NADPH-dep_FMN_reduc_SsuE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03567">
        <property type="entry name" value="FMN_reduc_SsuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="188" mass="20164" checksum="71CC740943760B49" modified="2018-12-05" version="1">MSKIVIISGSPTPGSRLNALIQSVESSLLAQGVEVNHIRVAELPAEALLHANFKDEAIVNAVSLVGDADGVVIASPVYKASFTGVLKAFLDLLPQTGLHGKISLPLFIGGTIAHLLSIDYALKPVLTALGGRHILGGVYAIDQWVERLEDGGFRLAEELRERLDKASADLIEELKWLDIRAKEKAVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVX7</accession>
    <name>A0A398CVX7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hemolysin D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_17530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0073 (Hly-III) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03174">
        <property type="protein sequence ID" value="RIE03174"/>
        <property type="gene ID" value="D3H35_17530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005744">
        <property type="entry name" value="Hy-lIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01065">
        <property type="entry name" value="hlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="211" mass="23555" checksum="97DCB6A79C36E850" modified="2018-12-05" version="1">MANTHVYSRKEEVANAITHGIGTLLSIAALVLLIVFASYKESAWHVVSFTIYGVTMLLLYAASTLVHSFPEGKMKDLFETFDHSCIYLFIAGTYTPLLLTALRSPLGWSLFGVVWGLAIGGVVFKAFFTKKFLVLSTLFYVAMGWIIVFAWGPLRAELQQGGLNLLIIGGLLYTLGSVFYVWRGFKYHHAVWHLFVVAGSVMHFFAILLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW36</accession>
    <name>A0A398CW36_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">mutL</name>
        <name evidence="8" type="ORF">D3H35_04570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04758">
        <property type="protein sequence ID" value="RIE04758"/>
        <property type="gene ID" value="D3H35_04570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00149">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020667">
        <property type="entry name" value="DNA_mismatch_repair_MutL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="DNA_mismatch_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_mis_repair" evidence="7">
        <location>
            <begin position="209"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="MutL_C" evidence="6">
        <location>
            <begin position="466"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="378"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="652" mass="71487" checksum="068AAEB41C52264A" modified="2018-12-05" version="1">MGIIRPLDEHLANQIAAGEVVERPASVLKELIENAVDAGSSRIDVVAEEGGLSLLRITDDGAGIQSDDMLIAFQRHATSKIAAAKDLFQISTLGFRGEALPSIAAVAKIRCVSATDNGGLARIVEIEGGAIRKDGETNAPKGTEMTVRDLFFNTPARLKYMKTVQTELGHLSDVVYRQALAHPDIAFTFQHNGSTLLRTPGNGDLRQVVAAIYGSSAAKSMVEIQGSDPDYSIAGLTALPVETRANRNAVTVLVNGRYVRSQAVMQPLLQAYHTLLPVHRFPLSVVHLRMHPSLLDVNVHPAKLEVRFSKEAELRTFVEETVKRALSAQAYIPSGSSTTSRTAKPQTWTQEQIRFQLPPAGAQAETAAAGYANSLPNTASPIAGHNPPGIGESSAQYDAPSPDRRAEQRADQSADQRDERGQRFDSRSDFRSASLPGSPVPERVWQAAFEPPASASAKPTFPELSWIGQLHGTYIVAQNENGLYLIDQHAAHERINYEYYYEKFGKPEEASQELLLPVTLEFAPDEHAVIRDRIASFESAGVYLEEFGGNTFIVRAVPHWFPEGDEADIVREMAEWVLRERKVDLHALREKAAIMCSCKASIKANQSQSREAGEKLLERLGACGQPYTCPHGRPIVVSFSTYELEKMFKRVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW76</accession>
    <name>A0A398CW76_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04798">
        <property type="protein sequence ID" value="RIE04798"/>
        <property type="gene ID" value="D3H35_04835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="341" mass="37969" checksum="5554A964EC9D724E" modified="2018-12-05" version="1">MENTALLSPADVTVIRRYVHTKYAPLPGGRRAEIVADAIRRTLEKRLPDLPPEIKGPMTDELIRRCLVAEQRDVRPDDVFDICAEMDIENDKMELISNSLLRWLDDRAPGGRWSPEQIASRIARRKAAGLESAIGVIEPNRSSSSMRLRSWAWAAVTALATAVAAVSILLWPNAEPVPKTVSPEPQAIVSSQPASDIGMPKELQFAAIDSKAVKEYLRGRDALIAEEPYFGAIVESARAHNVHPLLLFAIVGQEQGFVPKTNKKAKEIANNPFNVFHSWEEYNTDIGDSSNIAAKLIARLGRERPEGQEPFSWFNETYAEDPAWSDGVRNLFVKLNSLPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWH4</accession>
    <name>A0A398CWH4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_11895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03374">
        <property type="protein sequence ID" value="RIE03374"/>
        <property type="gene ID" value="D3H35_11895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="161" mass="18240" checksum="1C906D6F10324808" modified="2018-12-05" version="1">MGYIMELRKFVGTRPLIMVGACVLIFNEQGHLLLQRRTDSLDWGTIGGALEPGESLEEAAARELFEEAGLKAKAFKFITVFSGADMYYKYPHGDEVYNVLAVYEAIDVEGTPTINDDEGLELRYFTLKEPIAEINSFTESILRKLGYIQTKTELKDFERLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWU2</accession>
    <name>A0A398CWU2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="8">KARI</shortName>
            <ecNumber evidence="8">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="8">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ilvC</name>
        <name evidence="12" type="ORF">D3H35_10250</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03671">
        <property type="protein sequence ID" value="RIE03671"/>
        <property type="gene ID" value="D3H35_10250"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00435">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014359">
        <property type="entry name" value="KARI_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000116">
        <property type="entry name" value="IlvC_gammaproteo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="10">
        <location>
            <begin position="3"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="11">
        <location>
            <begin position="183"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="26"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE03671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="330" mass="35717" checksum="D8CC440E081273B0" modified="2018-12-05" version="1">MAVKLFHEKDADLGILKGKTIAVIGYGSQGHAQAQNLRDSGLSVIIGLRNGKSADAARNDGFEVLSVADATRKADVVQILMPDETQASVYKNEIEPNLKKGAALMFSHGFNVHFGQIVAPQDADVLLVAPKSPGHMVRRTYVEGFGVPGLIAIHQNGTGKAFEIGMAYAKGIGCTRAGVIETSFREETETDLFGEQAVLCGGASALVQAGFETLVEAGYAPEMAYFECLHELKLIVDMMYEGGLASMRSSISNTAEYGDYVTGPRIVTEETKKAMKAVLTDIQTGRFARDFILENQSGRAFLTATRRNEAEHPIEVVGAQLRSMMHWIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXI3</accession>
    <name>A0A398CXI3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03931">
        <property type="protein sequence ID" value="RIE03931"/>
        <property type="gene ID" value="D3H35_08175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="226" mass="24819" checksum="95E7448E3AB26595" modified="2018-12-05" version="1">MTTRSSTPEKCTIRKRGSIICERGIDPSIGRFISKDSYEGDLANPLTLNLYTYVYNNPMMYLDPSGNIGWRQIDNLLMGIGASAGDAIMDMLKSPRTLLQLGRALIAGDLSIVDLGKAIGASATEPIKYLVEYSKHVWGGKPTNAEVKEYGKQLGNVLQMALGSSAAMKIIAKAVPRLAKGLKAVEAASCNCSRQGLRFKQTKGRKTSKTLKSEIWFSRRMKRLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXY2</accession>
    <name>A0A398CXY2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03854">
        <property type="protein sequence ID" value="RIE03854"/>
        <property type="gene ID" value="D3H35_09895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029441">
        <property type="entry name" value="Cass2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14526">
        <property type="entry name" value="Cass2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AraC_E_bind" evidence="1">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="131" mass="15102" checksum="2F32F123483FE084" modified="2018-12-05" version="1">MGRAARAPRRNSDRSEPAVMIGFEDYSRGCELVPGQMPKFHYIAAAEVDRITDVPDGLFSKEVQEAEYAVFSLRGPLSNISGLFRYIYDEWLPASEYRLDPQMMADFEYYREPVNDRNDARVDIYIPIVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYR1</accession>
    <name>A0A398CYR1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine kinase</fullName>
            <ecNumber evidence="1">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_08590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04134">
        <property type="protein sequence ID" value="RIE04134"/>
        <property type="gene ID" value="D3H35_08590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="278"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="378" mass="42536" checksum="B755434E16A425B1" modified="2018-12-05" version="1">MQKWHQTLHKNTGLSPYVWVVFFILPFYFIFSSSSTWHIVAGFAMIVAFFVCYVLSFVSKGWPVYVWTSVLIAISITMTVVFGYVYFALFLAFFIGNLKSKAGFFTLYTIHLVTTLATINYGIVTKNSWLLSQFPFVLISLIAVILLPVNTYNRNKRDQLQGQLEDANKRISDLVKMEERHRIARDLHDTLGQKLSLIGLKSDLAGKLVRKNPEQALQELSEVRQTARTALKEVREMVTSMRGMRFEDEIFRVGQILKAAQIEFTLEGNAKLVQTSLLNENVLGMCLKEAVTNVVRHSGATACTVSIELTRAELVIRVKDNGVGPPVPEGYARGNGLRGMKERLEFVNGCLDIQSDNGTVLTMKVPNVIKQPLEEANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ08</accession>
    <name>A0A398CZ08_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">proC</name>
        <name evidence="5" type="ORF">D3H35_05940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04164">
        <property type="protein sequence ID" value="RIE04164"/>
        <property type="gene ID" value="D3H35_05940"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="3">
        <location>
            <begin position="2"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="4">
        <location>
            <begin position="159"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="283" mass="29972" checksum="04C0337231B788C6" modified="2018-12-05" version="1">MKIGFIGAGSMGSLLMEAFIATGAIQPDNIVASSRTPSKTAKLAEKFPGLAALPSNSDTADASDLLFLCVKPMDFRAVLEEIAPVMSPEQLVVSITSPVTLSQLEQVLPCKIAKIIPSVVNSAYCGASLFMWGSRLAPGDRTLLWDLFSHISRPVEIAEEEVRAASDLSACGPAFISYLLEEFIEAAVTTAGINREKATELAGEMLLGTARMLVEQRYSTAQLQAKVSVPGGITAAALEKLKARTTGAFADVFRTTHEKYAEDLSKVDASLASAIEAAGNDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZG2</accession>
    <name>A0A398CZG2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05247">
        <property type="protein sequence ID" value="RIE05247"/>
        <property type="gene ID" value="D3H35_01625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="279" mass="31880" checksum="A99F1C8B6C39D62A" modified="2018-12-05" version="1">MTIGQFSERTGLRPKILRYYEEVGLIVPCLRSANGYRKYSESQVETALLIHSLRQADVSMSGIREFLTATPGRRDELLAEWRSLAEIKLLSVKIANQFLQGFDSRTKRMHLVHWDCSRTVAWFSVKEIGWGASLPREVWRMCKEKFSPSMIAERAGYVRFAEAGEEAGTLQPEIGFVLENENQAPKDGRLEIVPPTLFATMSCSWDLPASCKPILSTIARFQFETVGEPLRKIAFRDERNYTLMVPVLIQGKHSGRSENNDSRSEHFRAAWHLRNGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D059</accession>
    <name>A0A398D059_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04851">
        <property type="protein sequence ID" value="RIE04851"/>
        <property type="gene ID" value="D3H35_05130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="688" mass="74547" checksum="684A880499B592FC" modified="2018-12-05" version="1">MKEGKWTRLRTTVTNLTDRDLKGELSITVVLPNGGYNQRYAVPAELPKGSPIEIEITVPGMSYNKQNNRIAFTDSSGKDVPVAIGKEYVEASSIGMSTVGVVARDPDTLNFLPILNQKGYNLKMVPIAEKDIPNTLQLLEGLDILLLNDVATADWTDLRKNALRSWVQQGGTLIVAGGAGYAKTAEGLGDLVPVAAEGTTKLDATKGLEQWGDGKPLAAGYPVTVSTGKLQAGNATAVSDGTIVAAERDYGKGKVAYAAFDPSLEPFVSWTGSPVFWSHFLSGSVNPYSQTGIPGFGSNNENWEISNALNQFPSIKTPSYSLLLIFFIAYLLIVAPGLFLLLRKLDRREWAWWIIPIVSIVSSVVIFTIGSSDKNSTLTHSLRTMELSGTGEAVRSASVAVFVPRGGDVTATFDAGAIALPYQSDGSGSTGNVLTNSTEQAIRLLPGNTEVEWKDVPYWSIRKTWMQYSSASSGHGQFNVALNKQAATYEVDVRNDTEADLTSVALLLSGNVYPIGDLKKGESGKVVVPITRPVQVSFYSDYGNQLFQQNVRNGQDRYARERGLLNGYMNQLANKGSLTKPVIVGYSNDKTGWFEVNGKKAKSDNLTLWVQSFELNDPNGNASGDILPGRYSRSLRIRRCKASATNRARGGWICTTAAWSSNMPSLKPQSQTEKIPVPGKCPFTRMNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D125</accession>
    <name>A0A398D125_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_02135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05191">
        <property type="protein sequence ID" value="RIE05191"/>
        <property type="gene ID" value="D3H35_02135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="308" mass="34032" checksum="698D4DB8661425CA" modified="2018-12-05" version="1">MIEKTSELILETRGLTKKISGKAVVSDVHLKIKRGDIYGFLGPNGAGKTTTIRMLLGLAKPTFGTVRIFGQDIRRDRLAILRKVGSLVEYPSYYGHLSAYENLETVRRLLGVSRNRIDEALSVVRLSKEAHRPVKGFSLGMKQRLGIATALLGEPELLILDEPTNGLDPAGILEIRELIKSLPRTHGVTILISSHLLSEVEQMATRVGIIAKGNMLFQDKIDVLKRQAKSRISLGVSDPESAWRLLLSQGHRAEWDRSRLTVEQASDQAVASIVAGLVRQNYQVYRVEEEVASLESIFLDITGSEGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1K1</accession>
    <name>A0A398D1K1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VanZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_00875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05371">
        <property type="protein sequence ID" value="RIE05371"/>
        <property type="gene ID" value="D3H35_00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016747">
        <property type="entry name" value="Phosphotransbutyrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019083">
        <property type="entry name" value="UCP019083_VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="13"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="169" mass="19025" checksum="0F7A666DF6AB9C3C" modified="2018-12-05" version="1">MTVKKSWILGAALLLLFCVIAAIFALSSQSYNTQTIQPLLHRTLSVDKAERIVPNLDIRYDGKEYRRDVNPFGLIEFLLRKGAHLFVYGVLAGAAALVLRMFRLRTSVVVGLSLLTVLLVAILDEWNQRYSTARTPTYQDVLVDLTGGMLSLAVCYGISRLYRRFSRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D2G7</accession>
    <name>A0A398D2G7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05264">
        <property type="protein sequence ID" value="RIE05264"/>
        <property type="gene ID" value="D3H35_01715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="336" mass="37372" checksum="E8681F2FEE752C04" modified="2018-12-05" version="1">MSLMEFCWTLPVDPNSFAASIEQACAAESHRYGAVLVSSLPKGMDPWVLSTAIGQRTKEIRLLIAQNTNYTLPTVTAKAWNSLKTITGCRADLNIVTGSYLPELAKHGKPLNHSDRYKKTYEFVEILQLLKKGKTSFNGDFFQINHADVTPPFEAEDSGNIFVAGSSQDAETVAAFVGDRYVVYADDVNTIRNKFAKVKAMGDSCSRQVKCGIFIDIIARRTASEAWACAEKMVADSTYIQRRLNKAYVHQADSIGVRNHGKYFIQDDYKVDQHLWAGLSQISDSVSLSIVGSYLDVITALKRYEEAGTDYFIVSGSRNDREIERIGQYVLPYANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBM6</accession>
    <name>A0A398CBM6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease R</fullName>
            <shortName evidence="6">RNase R</shortName>
            <ecNumber evidence="6">3.1.13.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">rnr</name>
        <name evidence="9" type="ORF">D3H35_29505</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.13.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RNR ribonuclease family. RNase R subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.1" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00180">
        <property type="protein sequence ID" value="RIE00180"/>
        <property type="gene ID" value="D3H35_29505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008859">
        <property type="term" value="F:exoribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01895">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040476">
        <property type="entry name" value="CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013223">
        <property type="entry name" value="RNase_B_OB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004476">
        <property type="entry name" value="RNase_II/RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011805">
        <property type="entry name" value="RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17876">
        <property type="entry name" value="CSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08206">
        <property type="entry name" value="OB_RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00358">
        <property type="entry name" value="3_prime_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02063">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="632"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="730"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="911"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="967"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE00180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1027" mass="112276" checksum="50ABC2F9A5E01A6D" modified="2018-12-05" version="1">MPLCTEQELLDFMRETAYKPMTYQELEKHFGIANAEEFKAFLRMLTEMENEGKILLTRTDRYGVPERMNLLRGRLQAHPKGFAFLLPEEPDHPDVYIHANDLQSAMNGDTVLVRVTSKSDNGSRLEGEVVRVVKRAVTQVVGLFTSHDSFGFVVPDDKRINKDIFIRQESFLGAASGQKVVVKIVKYPEGRSAAEGEIVEILGNKDEPGVDILSIIRKHGLPEGFPEEVLAEAEAAPEVITEDEIVSQGRRDLRNKVIVTIDGEDAKDLDDAVNVEVLENGNWLLGVHIADVSYYVREKSKLDEEAYNRGTSVYLVDRVIPMLPHRLSNGICSLNPKVDRLTMSCEMEFDPRTMRRVRHDIFTSVIRTKERMTYTNVRKIVQDEDPEVSERYADLVDTFKLMRDLAMELRGQRMKRGAIDFDFQESKVLVDEQGKPYEIIKRERSIAEQIIEEFMLAANETVAEHFHWLKVPFLYRIHEEPEGDKLVHFMQFAGNFGYAVRGKGNSVHPRALQTLLEEIRGKKEETVISTMMLRSMKQAKYDAQSLGHFGLAAEFYSHFTSPIRRYPDLMIHRVMREVIENGGALPEGRFDVLNAKMPEVAQQSSERERTAVDAERDTEKLKKAEFMLDKIGEEFEGMVSGVTSFGMFIELENTVEGLIRLSDMTDDYYHFHELHMALIGERTSKIYRIGDEVKIRVARVSMDDHTIDFELVDMKPRSYGGGRVNFVDSRGGGAGFGGKRKKRGSGGSGGGFGAVAGRGGGQGDRRGKGKAQPGGGKGKSERGSFGGAGSPGAKKGGRGAPGGTGDSGGHNGERESLGRVGVQGDQGGLGGFNGNEGGSGGKNVARKRGGEAGDGAVRGDIAQTSSAKREGVVAVAETAVAGVALQSGGKKRKGGSGSEPAAFDPNAPRGGRGGKKGRDQRGGRPPMDQTPDVNSVSGPRVKRKKGTDMWGLPISGTLSRATDDGEGGIIGEPRKKKGPGGRPEGKGNRAGGGRRSTDAGAGATESPAPASPSGETAPPKRKKKKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCH6</accession>
    <name>A0A398CCH6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_28915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00433">
        <property type="protein sequence ID" value="RIE00433"/>
        <property type="gene ID" value="D3H35_28915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017223516" evidence="3">
        <location>
            <begin position="26"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="348" mass="36418" checksum="542FEC39740DE452" modified="2018-12-05" version="1">MPRWLRSGLAAILFLVWLAPAQVSAYSYGDANTEDVAETFKLIESSLGGASADWSAAAAALQTRRSEIKSHFGEAVAVTLDKNAEAKDAKLLIANFKAVLVMNLDRRFTYAKKDLGDYAGAKLLLAKAKATYDVLAPYLSSGTDEINQAFDDALEALGNPGLFGVGKKEADPDVFKKKVDFVYAKVKPSFPYKAYVKPVVKEEAKPSPSKEPSVASPEVKPDKKPAAATNEAAATATPSASPSVSPSPSPSPSESAEAQPSPSASASAEPSQEASEPEASESLAPSEDAGAATAEAATEDQPSQEASAGHAPMERSNKTNGKVTVFVIGGVVIVGGGILWFIRKKGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCV9</accession>
    <name>A0A398CCV9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_29945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00255">
        <property type="protein sequence ID" value="RIE00255"/>
        <property type="gene ID" value="D3H35_29945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025883">
        <property type="entry name" value="Cadherin-like_b_sandwich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12733">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="SSF117281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017214967" evidence="1">
        <location>
            <begin position="32"/>
            <end position="2883"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="423"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="1726"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="2656"/>
            <end position="2721"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="2722"/>
            <end position="2782"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="2783"/>
            <end position="2846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="2883" mass="310352" checksum="33AA66695B336876" modified="2018-12-05" version="1">MRNHWISGLAKLLIAALLLQSIPLVYGSGNAAHAEGAEQVSDDLTDYTWKRADSGTFKPAARQAASMAYDEAAGNVVLFGGESSVLLNDTWLWDGSEQTWQEAAVSSTKPVARKYAVTAFDPVSQKVLLFGGEGSAGVLNDTWLWNGQTASWEKLTPAISPSQRAGAQLAYDGEHLILFGGYKISGGTKTSLGDTWLWDGTNWTDVTPTDPGASPPAAYNGQMTFDGQSAVLYGGITGNVTVNNGTTDVTMKDSSPKLWHWNADTLAWSSTDGPESFGRWGHTMAYDGRRVVFFSGARDYLHSFNGTLITDLKMPSSVYPYPRTGLAYGLKGGVWEGYPQVGSSGTGFQDDVGYPGQLQLYPNQRPFPLTNASMAFDGTNFVIFGGHRDAVDVWDKHQIQGGHKLETIPAGVMNETWVFGYTPPSPPGIKMVSEPIINLDPAHLDDTVSVVTSVYSLGGKPVTSRGVEYRPYTEAGSADWIAMPYSADPQATGSFTVTLTGLTWQQEYEVRSYAVNEIGTSYTPVERFVLEDDPSMEEPDVRFDRIGPSVLHVKDKKRIVAVGEGVTNLLRKPLNQIHYYLKNGGSITPLNYNILSKNQLELTWEADLPPGSYEVHLEHDTYQDYVYVDDLGTEEWNEGLALINVDFYKPRNFDRIDVPSTASGNEQTSLWLQGPFTETPSKPKEYVLNDTSEVVTINGNVLFKGSRLVVDKTDSAKTVITGEGRLYVNSGSSQGASLPYTLHDGPFAFDSDDFSLILSGNSAADYMGIDMPFKANKLTFAKDGLNLSGNLEVGFTAGSQKISSSIPISGVQYRNSRFELSGTYAMNKSFKVGPLDVSNTQFVIDSRVPYISVKGTGKLPNDSLGFDLLMKVKQGRLDEIGFGMYSKTKLASTGLQVNYLFGNVNNLAGKTQIPQRLGVTGSVADIIVPELKHPSVSYKFNLLGTDSIAVDLTNYGFDATGIEYYYWLPVNNMSMQTVVNPTVAGIPGFTSPGFLAKGDINVFDTIKGVIAAYSFNKKGYSGVLKGTVYVPKGIPRIGGVTVRNVVLSVNEKGVSGLFKHNGINARVTYTFQNNTILFEVEAEPPKKSWWEKGLDLYNSVNDFFEKTEPLGDLLEEIFLFNPNTSSSFNIAAADDWMKYFDFTQFNVANNVASTTGELKKVYELTPVRLAFQPEDTTETEVSARIADGQLTAVDRTPLVTTKADAAANGQISSVFPVKRAYEALIAINGDQRSAVLKASSAEKPTVEKTVLTEVVYDADRDTTYMRASLYAGSWKLITGESVRISVNELVFAKKSLTLEQLAGVWAQTADRSVTSLNIEEAGVYALNIDAGSDEVVLYKPDGRPYDLQGSQNQAGWNSFLDADDNRHVLLNAIEPGTWLIIADESPKAAINRVPAKTTTDELKQWVQDRAYPTFFEMSRTTNGQAIVEIYGADEETKLYMPSGELYSLQPDPNLSGLNVAYDESQNKLTVWLDKVELKGQWKVVSGGFTSFAAYKTSRKFKSIKPLLDEGRYSKYFELAEKGDYMLSVSGGNTDTVIYAPNGKPYTLSFEDQSGNAYLQPAADRTSSPSAGGDPLNQTQIVTPNPVQDGRDMLYVSLLNAPAGKWRVQNGTKVDLQIQKLIPSPDVKASADSIAGANNRIRVTWSTENAAADTEVAIMLTGSKDAYVGEVLAEGLAAAGSTVIDIPEMMIPGTYYVTVAATSVDKAPTYAIVEEPVVVSAPYSLNAPAQLSVQSTGNGEVSLKFSSVSGQVERYRVWVGEGADVQPATPVLDFAPEPGASQQAVISGLRVNEDYTIAVSAIGEQEGRLVLSPLSDNVSLTLPAPQPAALTVSVDAGSNLVANRTYKSYDGSDIQLALTAADQAKLDVTTNQAADLTFTINGHTFDSVHVAANGSYSFDLNERLETSVLEEQEYKVTIEAVNARGDRSVEYRRLFVDRTAPLLIASGGDDATGAPISLNGTIDTSGKVLIVGQTEVGAKLDINGVIVPLDDAGRFVYYAPLAWDSSIDRILITIKASDEAGNTTAYGFEVLKAVAGADLTYPGDLAALTTVGATMSAPYQFGTVDYETVAYLNKVRVYAAPMVSSSVVSIEGTPLPTSGYVEVAVPDAGRAVQIRVKPAGGLSEQLYTLNIETGSSAALLSTLTLKTQSGEAVAAQPFTGTEETYNVYVDNSVDGVTLTPDALMAGSVIRVKGQDVQNGQPSQTIPLQVDDNPIPVTVVSPDGLTTRSYQVVVSRMPSGNSELQQLGIATAGVSLTPGFDPNVLQYQVLVPHDTTAFALQPVAQQADAAVLVNGQESNGSTVTIPFGGESLSVAIEIRAPDDSERKYTLSVVRQKGAPAQAPLLTSLSASTALDGEFNPYQFFYGTKGQTENYLTTITAVAGDPQAIVTVKGVSLQGGGKFMPSLSLGENTIVVRVESADLTASRTYSINIKRVSKPEENLRHSTITGSAGDWSDQIEIVRTRTQEGTAVDTVRLDAEKARHILDKAKQNKDSIARIYVTDIPDDPADERMVKLSADSLSLLADGGMSLQIVLPEAVIDLPAASLQQLGKEGQDAYFRIIPVIADDERGEVTSRVLASDLVQQAAGGQPASVIGHPVKIETNYSGFKTKLLFPLTDLRLPADKAAAKQLLSELAVYIEHSDGEKVLAPGEIRYDAEGNVTGIAIEINKFSTFAIVRTNAANTVLEPYMSGYPDGTFRPSQSIKRAELAAILHRLGAEGTLSAQAAGYADVAAKHWAAEAIAYMKRSGLMLGDNKGLFRPEDAVTRAEMASIVARLLPASAANQASAGAYSDTHGHWAADAIKKAAQASILQGYPDGTFRPDNKLTRAEAVQILNKLFQRPTAGVPSSSWLDVPLSHWAIREIESASGTVEVSSDGTVLVEPAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD55</accession>
    <name>A0A398CD55_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_28375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00345">
        <property type="protein sequence ID" value="RIE00345"/>
        <property type="gene ID" value="D3H35_28375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005085">
        <property type="entry name" value="CBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM_fam20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03423">
        <property type="entry name" value="CBM_25"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01066">
        <property type="entry name" value="CBM_25"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017357664" evidence="1">
        <location>
            <begin position="31"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="816"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="1004"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="1193"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="3">
        <location>
            <begin position="1370"/>
            <end position="1476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1477" mass="159119" checksum="CDA61F1696A005AB" modified="2018-12-05" version="1">MFKSKWLAKTTAALAGALLVLQASVTPASAEIAAAHVYHNHMPNFWAFYDVNQYSSTSVGSPIRYTYDGDVIALKNNPPAGYTYFLPNGSPMPHDDLVSYYSHHAKKGAYLTWPWSVANDLRSSQPTAQMHVTMSGAVINNVNNIIQRGNVSDYNNPNWWQPWRTAYSNLITTNGKKTLDLIHFSGHHSMGPLTGNDYLLKDLIYQNVTLAQPYFLGTAFKSSKGFFPTELGFSERIIPVLDKLGIKWSVIGNNHFSRTLKDYPLLNSPGTDTMVSPPNRADLQNTSTVGSWVNQNMTNEQQVVYNKYPFASTPHWVRYVDPATGAESKLVGVPVAQAESWEEGFMGSTKATALKPFEGLTAQKQFFVIAHDGDNNMGRAGSEETWRNAANVTYTDSGVKGMGIDEYLIGNTPAASDVVHVQDGSWIDTRDSSSDPTWYHWHLPFGIWKSQFSSFNQVNQTSLAPKKNLSGIDDGMTVSFEKGYHYLERNFALLQAALNYAKTAEQIWLDDHLNYWHPSTPQENEITYPGNQLNPWMLSYPVKGDPNNDYAGGANPAELAWYFLLPALDSGFGYYDENVDDNVKPTLSFNQSLYFSKPYVQQKLAKDKTGPSVWWPQRYPYNPGSANVSKAEGWTLHHFDNSFAIYSYAYDTSGIQNIKVKVRAHTSKQADASDNTFKVYDPAAMQAAGVQGIDPTKVGAWTEYPMNVRDLTPDINGVDWQPSGKATMAKVPAQEIGNLYYSYINNYRDQLLDYYIEATDSKGNVTRSDIQQVYVGAGKYNLVNGKYVEDINGTVTGTHPFITDQPDIPDDESPSVPTDVAAQTLNASSIKVTWTASTDNVGVKGYEVYRNGTKVGTTASTTYTDNGLASSTTYSYTVKAYDAKNNFSSLSAPPATATTPAGNNVTIYYKRGFATPYIHYRPAGGTWTTSPGTAIPESEVAGYNKITVSIGSATQLEACFNNGSGTWDSNNGSNYLFGVGTWTYTPTGNIVAGAPIVDTEAPSVPTNVTAQASTASTANVSWSASTDNVAVTGYDVYRNGTKVGSTASTSYLDTGLAGGTAYSYTVKAYDAAGNKSDLSTPPAIATTSAGNNVTIYYKQGYTTPYIHYRPAGGTWTTSPGTAIPVSEIPGYNKITINLGSASQLEACFNNGSGTWDSNNGANYLFGVGVWTYTPTGNIVSGPPPIPESDPPTVPQNVSAQAVSAGSISLTWTASTDNVGVAGYEVYRGATLAGTATGTTFTDSGLSPATAYSYTVKAYDAAGNRSAASSPPATATTQAGNAVTIYYKNASFTSTNIHYKLDGSTTWTALPGVAMQPSTYSGYKTVTIQLGSAAGLTAAFNNGSGTWDSNGGNNYHFAAGEWTLVNGTITSGVPQPDSVTFRVTVPASTPAAGPVYLTGSFNSWNAADPAYQLTKGTDGVYSITLSLPAGTAIQYKLTRGSWATVEAQSNGSDIANRTLTPSGGAQTVSLTVVRWKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDG7</accession>
    <name>A0A398CDG7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Elongation factor P</fullName>
            <shortName evidence="8">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">efp</name>
        <name evidence="12" type="ORF">D3H35_26475</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the elongation factor P family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00743">
        <property type="protein sequence ID" value="RIE00743"/>
        <property type="gene ID" value="D3H35_26475"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="11">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="10">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE00743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="185" mass="20623" checksum="9B4834AF91B34E05" modified="2018-12-05" version="1">MISVNDFKTGLTIEVDGDIFSVTDFQHVKPGKGAAFVRTKLKNLRNGNVVEKTFRAGENVARAIVENRQVQYLYNSGNEFTFMDNETYDQFELTKSQLEWEINFLKENMNVNIASYQGEIIGITLPNSVELAVVETEPGIKGNTATGATKNAKLESGHNVQVPLFINEGDVLLIDTREGKYISRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEM6</accession>
    <name>A0A398CEM6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01163">
        <property type="protein sequence ID" value="RIE01163"/>
        <property type="gene ID" value="D3H35_22425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="299" mass="34102" checksum="FDB727650C33731A" modified="2018-12-05" version="1">MEKDSVINDPISIRLGDVTFQLQEHHDFRWLNHLGNAFCVFDQQDSGNISFGMEINGRKRFINYAGASPLAYTGSPDDAVARLLRAIPLYQQLEHPALIKLVDHFAVDKGHAAVFEWFEGECLHSHWSFPPPAKYNHPGSPFYRFKQLPIEKRLDSMDTILSFHEHVEARGYVAVDFYDGSILYDFKNDITRICDIDFYRQAPSINDLGEDFWGAMRSKSPEEFILGAPIDSRTNVFNMGAIAFGLLGGEMDRSYSGWDAGPLLYEVALRAVSDRRELRYAAVAEFKRAWDTARNSQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CER3</accession>
    <name>A0A398CER3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SMP-30/gluconolactonase/LRE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_28430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00352">
        <property type="protein sequence ID" value="RIE00352"/>
        <property type="gene ID" value="D3H35_28430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGL" evidence="2">
        <location>
            <begin position="19"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="301" mass="33021" checksum="040EA7E54D0895C6" modified="2018-12-05" version="1">MDGIIERKPMAVRAPQSELGEGPVWDERSARLLWVDIIHARIHCLHPESGEVETVAAPEWISTLIPSSQGRWIAAAYHSLFLWEPANGNFEEILRMEHFPEHVRFNDGKAGPDGGIWAGTMDMNGARADGGLYRIDPSLGWEEKLSGLVCSNGLDWSLDGSEMYGIDSAYRQVNAYAFDPLSGTLGERRTAVELATEFEGVPDGMCIDLEGMLWVAQWGGSRVARWNPADGSLLSAVRLPAPLSSSCAFGGRSCDALYMTSACEGMNGAQRSAYPLSGSLFRLDTDHLGIRGRQPFRFDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF09</accession>
    <name>A0A398CF09_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000055">
        <property type="protein sequence ID" value="RIE00472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00472">
        <property type="protein sequence ID" value="RIE00472"/>
        <property type="gene ID" value="D3H35_28225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="67"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="226" mass="24546" checksum="22FF751FC9092861" modified="2018-12-05" version="1">MYGDIYEGNGRTSGAALCCVIARHQQSDGETAEGLELLSAEEKRQLLHAFNDTKASYPESQTIHGLFEEQVKKTPDHTAVVLESESLTYAELNGRANQLARVLRGKGVGADRIVGILAERSLEMIVGILGILKAGGAYLPIDPDYPAERIGYMLEDSGADILLTQKRLEAQTMGFAGEVLHVDDERLYAGDNTDLDHTGSSKDLAYVIYTSGSQEGRRALSWNTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF32</accession>
    <name>A0A398CF32_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucokinase</fullName>
            <ecNumber evidence="2">2.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glucose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_21425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01015">
        <property type="protein sequence ID" value="RIE01015"/>
        <property type="gene ID" value="D3H35_21425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004654">
        <property type="entry name" value="ROK_glcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00744">
        <property type="entry name" value="ROK_glcA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="316" mass="32886" checksum="6D67A3D07750EFD9" modified="2018-12-05" version="1">MSETIYVGVDIGGTAIKVGICSAKGDLLHTFEGPTGTEQGTQKILANIAGYARRIVEESPYDWEQVAGVGIGIAGFIDMAKGFIKFSPNLPLDNVPLKDILEAELNKKVRVNNDANVAALGEAWGGAGRGVHSCVLYTLGTGVGGGIVVNGRLIEGFSGMGGELGHMSIVPDLEAIQCGCGKMGCLETVSSATGIIRMAHDAVSRGDRTTLADVENIMAKEVFDAAKNGDEVAQRIVSRAAYYIGKSMATVAVVVNPQRFIIGGGVSKAGEFLFEQIRTVFHKYALDKAQEGVDIVAAELGNNAGVVGAAGLLLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF58</accession>
    <name>A0A398CF58_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01210">
        <property type="protein sequence ID" value="RIE01210"/>
        <property type="gene ID" value="D3H35_22705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="283" mass="32487" checksum="FEBE0EFCCC2CFF94" modified="2018-12-05" version="1">MRPKLILIEGLPGFGKTTTAQLVQEILAEINIKSQLFLEGNLDHPADYEGVAYFKQNEFDELLRTHEVSRDLLSNHAIKQGNDFLLEYQKIKSEYGSGFPDDLLRAVVKNDVYELPLNQHRRLIADRWKRFTANALNGPDTFVFECCFIQNPVTMAMIKCGAEEIVLSYVMELATIVERLNPLLIYVEQSDLDGSFRKAVKDRPKEWSESFINYYTNQGYGKERGYSGLEGTLQVLKARKKLEEEIFVGMKIAKKKVDNSSYDINDYKQVLLGILSEYFISTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFC0</accession>
    <name>A0A398CFC0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_13980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01886">
        <property type="protein sequence ID" value="RIE01886"/>
        <property type="gene ID" value="D3H35_13980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="392" mass="43034" checksum="6E39F7302AC83023" modified="2018-12-05" version="1">MSSNGLLYLSVVRSFLAPGAEVAQLPVPGYVPALLAVDLDGDRDVELTAVYCYQGEPYLLALKRQGASWYPVASLKGKGYGVTDFAAAPITRRDQMSLVIGWRTGQGSSELELLEWTPHGFQRLIEEGTEYNYLELEDMDGLRGRDGLCELALWTYDERAAYSVETYRWSGYRLVSAPDAYPYYFPRVARYYEALSVQAPGELLYRSGLEDARAKAGLSDLTAEPSVDLSRTFGLNSERERDPLLEEAIAGAFGLQRGKGEVRYYYNRIDLNGDGVPETFVLLTGAEVCGSGGCSAAVFQPGQRSEDGYVLHSRFTLVRSPIIVSNETTNGYHDILAEVSGGGQASAWHRLRFDGTSYPSNPSVEPIVADGTKVFGTRLVSDDLDVYRGIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFK1</accession>
    <name>A0A398CFK1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">7-cyano-7-deazaguanine synthase</fullName>
            <ecNumber evidence="1">6.3.4.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-cyano-7-carbaguanine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">PreQ(0) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Queuosine biosynthesis protein QueC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">queC</name>
        <name evidence="2" type="ORF">D3H35_24425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-carboxy-7-deazaguanine + ATP + NH4(+) = 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27982"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the QueC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.20" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01503">
        <property type="protein sequence ID" value="RIE01503"/>
        <property type="gene ID" value="D3H35_24425"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01995">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01633">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018317">
        <property type="entry name" value="QueC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42914">
        <property type="entry name" value="PTHR42914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06508">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006293">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00364">
        <property type="entry name" value="TIGR00364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="223" mass="24584" checksum="B70C8EC3F174B1DB" modified="2018-12-05" version="1">MDSGKKKAIVVFSGGQDSTTCLFWAMERFGEVEAVTFDYGQRHKLEVEVAAGIAKELGVRHHVLDMSLLGQLAPNALTRSTIPIAQEEGELPTTFVDGRNLLFLTFAAILGKQAGARNVVTGVCQTDFSGYPDCRDVFVKSLNVTLNLAMDYEFVLDTPLMWLNKAQTWQLADDLGAFDFVKDRTLTCYEGVMGEGCGQCPACELRARGLREYEKAIGEGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG73</accession>
    <name>A0A398CG73_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Threonine synthase</fullName>
            <ecNumber evidence="7">4.2.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_24410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01500">
        <property type="protein sequence ID" value="RIE01500"/>
        <property type="gene ID" value="D3H35_24410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thr_synth_N" evidence="6">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="PALP" evidence="5">
        <location>
            <begin position="100"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="462" mass="51174" checksum="A3A9F012762CE078" modified="2018-12-05" version="1">MDYISTRGKVEAIGFVDAVLMGLANDGGLLVPSLIPSVSADTLNQWEKLSYSELALEIFTLFVDGDIPREDLKKLVDDSYATFRDPEVTPVRRLNDSLSVLELFHGPTFAFKDIALQFLGNLYSYISRKNNSIIHILGATSGDTGASAIEGVRGKEGIRICILHPHGKVSKVQELQMTTVNDANVLNLSVEGNFDDCQRIIKELFADVDFKHRYHLRAINSINIARILAQTVYYFYAYFQAAKGDPAAKVNFSVPTGNFGDIFAGYLAKRMGLPVNKLILATNENNILERFVREGVYEPGEFHMTYSPSMDIQVASNFERYLYYLYGEDSQAISALMDGFKKDGRIVIPEDKLRTVQADFGAYGVKNDECLATIGSYHKENGYLLDPHTACGVAAADKLAEAGEVTVALSTAHPAKFDEAIRLIDIEQTYPAPIQALFNKPQIQKVVGGSNEEITEQLLSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGC7</accession>
    <name>A0A398CGC7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_24685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01550">
        <property type="protein sequence ID" value="RIE01550"/>
        <property type="gene ID" value="D3H35_24685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="654" mass="75603" checksum="C2FF52D5F7C34D28" modified="2018-12-05" version="1">MAVQSNLEVQITNDHIGKLLKFQPLRALSELIWNALDADATEIDIDFERNALDGLEHIIIKDNGHGIDFNLVDEHFGKLGDSHKVKDKVSPKGRKYHGKLGQGRYSGFVLGRRVEWVSLIKKEEELYEFAISGHDSNLKLFSKTEPSRTNGQNSGVIVSITDLINESADKIADKLGLIQNLTMIFAPYLLAYKDISIRVEGFKLEPAKQIINTYEFPLFAHNEEQLPVRGTLKIIEWKSSKHKNLYLCGQTGIVFEEEPSGFRSSSFSHSAYLLSNIVDDLWETNQIDVRTLNPDYNTLRELTDLTLRDLYRQKMASEASNEIKKIKKENIYPYKGEAQTVVEEAERQVFDICAVKLNQYLPDFSKAEKGAREFTYRLMKEALQSNPDSLQTILRELLKLPTEQQDELAAILEKTSLESIINTTNLISNRILFLNGLEQILFSDQYRKRLKERSQLHKILLRELWLFGEQYVYGYDDISLKNVLKKHLSILGREELAKEIDFKSITSLDDIPDIGLYRQYKYGRDDCYENLVIELKRPKCVIGTEEISQVRRYAHAIEKNNNFDKAKTKWKIVLLGTDLDEDARLESSQGDRAPGLIYKSKTGNMEVWLKEWNEIIQEAKGKHQFLKEKLELEVKDNEEGLNYLRMKYKEYIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGI2</accession>
    <name>A0A398CGI2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="6">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_16545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02326">
        <property type="protein sequence ID" value="RIE02326"/>
        <property type="gene ID" value="D3H35_16545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022337">
        <property type="entry name" value="Inositol_monophosphatase_SuhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01959">
        <property type="entry name" value="SBIMPHPHTASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="284" mass="30381" checksum="A87BDBD0EA7A776D" modified="2018-12-05" version="1">MVDNAPERVVGSKSFTAVAINCAAKAGEWIQSKIGSVKQLDTKYSMHDLVTEVDKGSERMIRNLIGTHFPHHSFLGEEGVEPGPEAAAKALQDVSDAEYLWIVDPVDGTTNYVHGFPFYSVSIALAHRGQVIVGVVYDPSRDELFIAERGKGAYVHGRKVEASKEGTLGTSLLATGFPAEHLTALPANLREIGAIAPKVRNLRSSGSAALHLAYVASGRLSGFWEHNLSAWDIAAGSLLVEEAGGRMSDLAGEPYHLGVRDIVATNSLVHDELVSELKKASAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGM6</accession>
    <name>A0A398CGM6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbonic anhydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00229">
        <property type="protein sequence ID" value="RIE00229"/>
        <property type="gene ID" value="D3H35_29790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="PTHR43175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="188" mass="21182" checksum="54B4A2E48A0D240F" modified="2018-12-05" version="1">MSIVPSLLAYNKQFVEEKRYRDFLTDKYPDKKVAILTCMDARLSELLPKALGFKNGDAKFIKNAGAILTQPFGSAMRSILVAVYELGAREVIVIGHHGCGMTEINPEGMVRKFIEQGIDPLAIKTLEDSGIRMEKFLRGFERAEEGVMHSVRMIRRHPLFPQAVPVHGFVMDPETGAVEVIVEDYREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHF5</accession>
    <name>A0A398CHF5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0735 ACT domain-containing protein D3H35_27625</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_27625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0735 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00519">
        <property type="protein sequence ID" value="RIE00519"/>
        <property type="gene ID" value="D3H35_27625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00707">
        <property type="entry name" value="UPF0735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008310">
        <property type="entry name" value="UPF0735_ACT_dom-cont"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025624">
        <property type="entry name" value="ACT_PheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="2">
        <location>
            <begin position="69"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="145" mass="16041" checksum="7EE8F7CE97411372" modified="2018-12-05" version="1">MAERYYVVREDLLPEGILKTEQAKELLRRGEAATIHEAAERVGLSRSAFYKYKDGVYLLEQTNRERIVTLSTDLEHRSGVLSKVLGTLASSEGNVLTIHQSIPLQGMANVVVSLDTSNMAGTLTELSDRLRNIDGVKRVAIIGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHU2</accession>
    <name>A0A398CHU2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_26225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00699">
        <property type="protein sequence ID" value="RIE00699"/>
        <property type="gene ID" value="D3H35_26225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="74" mass="8128" checksum="88EA2B1A3A822B65" modified="2018-12-05" version="1">MARKLMGPSFGKMFPVSVLLGAIVVVLADLAGRMLSSRWTCLRAFFTAGVGAPFFNLFAVFQEEFHNRFGAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHY4</accession>
    <name>A0A398CHY4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_16985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02403">
        <property type="protein sequence ID" value="RIE02403"/>
        <property type="gene ID" value="D3H35_16985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="136" mass="15588" checksum="7C5BEB36D328D1EE" modified="2018-12-05" version="1">MLYSHVKVIMVTSNENYPYMERSVVAGARHYISKSKVGQIASLIRLVYHDADQSMQLLMLSLVKYKELSYLDTFNLTPREKTIYLHKKEGLSNQEIADLYVLSISTVRNQITSMLNKIGASTTAFAFEKIHKLLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI09</accession>
    <name>A0A398CI09_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="6">RF MTase</shortName>
            <ecNumber evidence="6">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">prmC</name>
        <name evidence="9" type="ORF">D3H35_14490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01975">
        <property type="protein sequence ID" value="RIE01975"/>
        <property type="gene ID" value="D3H35_14490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PrmC_N" evidence="8">
        <location>
            <begin position="18"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="MTS" evidence="7">
        <location>
            <begin position="112"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="134"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="202"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="298" mass="32390" checksum="307FFEE0E29A5897" modified="2018-12-05" version="1">MGDTEQEHDRLRLPTLGQMWRQGAAKLREAGAEEADADAELLLLHLLGIGKTELLRDLREPAALAADGLDRWERLLARRAAGEPVQYVTGEQFFYGRRFEVGPGVLIPRPETELLAEAVLEAGGRSSLTVLDVGTGSGILAVTLAAERPEWRVLASDLSEDALSRASSNAETHGVSARVAFYQGDLLEPFMSGPVVDVLVSNPPYIPSGDVPGLQREVKDHEPRLALDGGEDGLNPYRAMSSQLGRLPRLPRLVAWEVGAGQADDVAELLRAAAEWDSVRFVVDYAGIKRHVIAERYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI75</accession>
    <name>A0A398CI75_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_20450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02976">
        <property type="protein sequence ID" value="RIE02976"/>
        <property type="gene ID" value="D3H35_20450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="87" mass="9348" checksum="63F0785B7E19D468" modified="2018-12-05" version="1">MTNKHSSKASPNGAIVYQIRLGGHLDRQWSDWFDGLTVTLADNGDTLLTGPVADQAALHGLLRKVRDLGMSLLSVVHVTEENLGGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI90</accession>
    <name>A0A398CI90_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_03455</name>
        <name evidence="4" type="ORF">D3H35_03485</name>
        <name evidence="2" type="ORF">D3H35_13180</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000021">
        <property type="protein sequence ID" value="RIE04924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000021">
        <property type="protein sequence ID" value="RIE04927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01752">
        <property type="protein sequence ID" value="RIE01752"/>
        <property type="gene ID" value="D3H35_13180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04924">
        <property type="protein sequence ID" value="RIE04924"/>
        <property type="gene ID" value="D3H35_03455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04927">
        <property type="protein sequence ID" value="RIE04927"/>
        <property type="gene ID" value="D3H35_03485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="125" mass="14366" checksum="9C54DA039CB3F3D8" modified="2018-12-05" version="1">MGIKFDMIGIVVKDMRKALDFYRVLGLEIPESANDAPHVEVAQDGFRLAFDSQEMIKDIYGGWEEPAGHRIELAFLCDSREAVDELFNRITERGYRGHREPWDAFWGQRYAIVEDPDGNLISLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIL4</accession>
    <name>A0A398CIL4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00698">
        <property type="protein sequence ID" value="RIE00698"/>
        <property type="gene ID" value="D3H35_26220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="117"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="303" mass="34201" checksum="DC07A16E4D10850C" modified="2018-12-05" version="1">MRLYYLPRGEAIKASVSSNRSVCTCWLSSIFAGGKAAAERKGTRLSLLCFPPFLAPERLDPARGTDRILNWIRQLYEGNRQPVKGCRLQLLFQELLNGIAQEYEAGAERKSAQSGIELAIAHMKANFRSKLDMGTVADIANLTLSSFSRLFKKTTGESPIEYLTKLRMDSAKSLLSQKKCTIKTVSSAVGYEDEFHFSRMFHRHVGVPPTFYRKVKKLRVAVAASLPYRDSLLSFGVEPVASVNLFRYPGMAVKEYELVFASQWEELERAKPDLIIGDFYHFSFRIDSKGSLPYQACWRIEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIV8</accession>
    <name>A0A398CIV8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02663">
        <property type="protein sequence ID" value="RIE02663"/>
        <property type="gene ID" value="D3H35_18465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="166" mass="18674" checksum="CF8CDD4DE1CE9C3A" modified="2018-12-05" version="1">MPSIVLLDMSDPDIAEELWSLQHAAYREEAKLIGVPDLPPLKDTVKDLQTSRETFYGMIDASDGELTGALSTSSGSNGRIVICRVMVRPDRFRQRIGSRLLEHVLFHGQSPRQAKQSVYEVTAEARNIPAIRLYERYGFYRSETYHPLPGVAMIRFVRASSSTTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIX1</accession>
    <name>A0A398CIX1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02320">
        <property type="protein sequence ID" value="RIE02320"/>
        <property type="gene ID" value="D3H35_16510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="182" mass="20414" checksum="306CEFE34E41404D" modified="2018-12-05" version="1">MNRHDLCPEAIDGRGGDDQVPDKKGNMAGWKQTLFEYVNAINEAGLRGEPDKLEQVSDSGHRARLSAKIQAFARREALEGIKSIRSEMRARIERSNSAGRGAVADVAVHSVRSFEQRGQPWLEERVERERIRFVLSGAGKWRIDSILPLATERRPASYSIEEELYDAAGSRENGWGFLPLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIY9</accession>
    <name>A0A398CIY9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_14910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02052">
        <property type="protein sequence ID" value="RIE02052"/>
        <property type="gene ID" value="D3H35_14910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="174" mass="19108" checksum="CF72656060C1FDAE" modified="2018-12-05" version="1">MIPELLWIIGFYAAAAALTHSVFRRHSGGDRRHYVLVAGNHQMQIEWYVRSLQQFSRRTGMDIGITVVLDNSSDDTGKIMERFARRGDGVGLIRAEEVKSSAEWERLRLGEASGPEEHSEHRGSAAEGAGGSEAGAGRKQVLSERLAALGALQASPQQVWVELACEDDVARLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ08</accession>
    <name>A0A398CJ08_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02723">
        <property type="protein sequence ID" value="RIE02723"/>
        <property type="gene ID" value="D3H35_18920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="191" mass="20895" checksum="F6201B12C71E7B31" modified="2018-12-05" version="1">MDCRQRRLCVRANGTDPTDIGLNNDGAVEGMKFYQSLREALPIKAADATADVKTNLFQTGKLPINMDGVSQLGNFTKEKLGFEVGAVPLPPMSNGKKPVSFAGVKAYYVSSFSKYPNAAKLFIQFATTQEAAVKNFELTGIIPARNGMDSDPAIANNEIVKAFTEQIKNSQPMPNILPATQIWALRPLRWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ44</accession>
    <name>A0A398CJ44_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maltose ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_16710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02355">
        <property type="protein sequence ID" value="RIE02355"/>
        <property type="gene ID" value="D3H35_16710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017282722" evidence="2">
        <location>
            <begin position="31"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="446" mass="47823" checksum="C7658F721D3537A5" modified="2018-12-05" version="1">MKKQLATISTLSLLALSLAACGGGNSNTNASPSASGPAASPTSSAPASTTPASEAPADEPKPEDGAKLVVWSAQEQQKYVETLGKEFEEKYGVKVEYQKVGSADALNKIQKDGPAGVGADVFVLPHDNLDRAVQAGVILPNDIFADDTKANFVKQSVDAVTTTDGILYGYPRNMETSALFYNKSLVKPEDLASWDAIKAFSKGFTDASQKKYGVMWKLDDSYFNWGFLAGSGGYLFGKNGTDPTDIGLNNEGAIEGIKFIQSMKEVLPIKMATATSDYKTELFQKQKLAIDLDGIWQLGTFTKEKLGFDVGVVPLPPMPNGKAPKPFAGVQAYFVSSFTQYPNAAKLFAHFVSSQDAAVKLYQIAGVVPARAGLEEDPAIKDNELVKGFLEQFKNVEVMPSIPETAAFWTATMGNLFSPIWDDGVDAKTALDKSVADMKTLISQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJB3</accession>
    <name>A0A398CJB3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_25445</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00918">
        <property type="protein sequence ID" value="RIE00918"/>
        <property type="gene ID" value="D3H35_25445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="184"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="253"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE00918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="467" mass="53087" checksum="D43C75444F986780" modified="2018-12-05" version="1">MKLRTKLWLLLVLSAAMSMVLFGYTSVWIGKIANKGYALFQLNPLAQSIVDSIEEQSPLGRDSLKLTLDLAHEEHPDIRLIWMDDQGQSIYDTAGLNPTYTFKDLARMMQNMPERYLTEDDVHILTQATSGEQSYFLLLSIPSSAMKQGEVYFLVRTHKSLLTLVVPLVLSFSIPFLLALWIFSRINKRIRKLNKALNQLNIQGDSPVIKLEDKSKDELGQLTQHYNSMALRIRSQFAEIQQFENNRNLLLSNLSHDLRTPLTTMLGCAEIIRTGNYKDETELQSRAKIILQRCRYMDKLLDQMLDISRQDADSLSLQLVNHNLSEIIRKIAVEYIMVLDGDQVVLDVDLPNEDIANAIDAPLMERALRNLLDNAIRYGKDGRYLGIRLSADEQSVNITVMDKGKGIPPEHQAHIFERFYRVDRGRTGEGLGIGLSIVKDIVEAHQGSIEMSSTPNVETVFRIKLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJC7</accession>
    <name>A0A398CJC7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfur carrier protein ThiS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiS</name>
        <name evidence="1" type="ORF">D3H35_17300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02455">
        <property type="protein sequence ID" value="RIE02455"/>
        <property type="gene ID" value="D3H35_17300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010035">
        <property type="entry name" value="Thi_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01683">
        <property type="entry name" value="thiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="65" mass="7058" checksum="E37E7A1AF263D50C" modified="2018-12-05" version="1">MELIINGLKQELDAHTIQDVIEHYGLAGKPIVVEADGAVLTAEQWAVTVVRPHMQIELVHFVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJF7</accession>
    <name>A0A398CJF7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01309">
        <property type="protein sequence ID" value="RIE01309"/>
        <property type="gene ID" value="D3H35_23285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="120" mass="13948" checksum="0488AE8E2DC4F016" modified="2018-12-05" version="1">MEDMLKRILSEIQEVKTDVQGVKADLIEVKADLIEVKADLVEVKAEIREVKTELKEFREDQAVTNKLLSGDTAGIKTQLRDKAKDDREFRSEVREWQNRTSRRIDNLEDRIDGVRDALNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJG4</accession>
    <name>A0A398CJG4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_12470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03466">
        <property type="protein sequence ID" value="RIE03466"/>
        <property type="gene ID" value="D3H35_12470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017302321" evidence="5">
        <location>
            <begin position="31"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="6">
        <location>
            <begin position="32"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="6">
        <location>
            <begin position="93"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="6">
        <location>
            <begin position="158"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="7">
        <location>
            <begin position="227"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="539" mass="59239" checksum="B782ACA1C12CF4AA" modified="2018-12-05" version="1">MSFFRSLYVPTAAFLLCLATVATPVQLAAAAESKLPFNDIADSYAKGAIVHLSTLGIVSGNGSGKFEPRKSVTRAEWVSMLDRLFAIEPVNGAIPAFADVPNTVWHYPWVQSAVELGLATGTSPSLFQPDKKVSRQEAAVFLVRALKQSLAAASSSNDKTYMDSDRIASWALPSVRQLQKLNVMNGDGGTFRPEDSMTKQEAAALLDKVLQRNAWSAQFQAAPAASIQLGWQYGQTTVQFERQVAQSNVNTLSPRWFFLGQAGTLEDSADAPLVAWAHAQGKKVWAMVGNHSDPSLTGKTISDATQRKIFIQALADAVRKYGLDGLNIDFENVSPQDRNGMTLFVSELAAALRAIPAKLSVNVSPDLGTDWTDAFDYAALGNDADYIVLMGYDEHWEGDAEAGSVSSLPWLRSGLDALLDKVPANKVILAMPLYTRDWYAGAAATMSTEWSLIRQNDQVRALHLKPDWNERLAQYSASYWSLGVQHRIWLEDGRSLSRKMELGLVKNIAGFAYWYMGGDSPDVWASMRNRLRFSTYTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJJ4</accession>
    <name>A0A398CJJ4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gap</name>
        <name evidence="10" type="ORF">D3H35_21375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01008">
        <property type="protein sequence ID" value="RIE01008"/>
        <property type="gene ID" value="D3H35_21375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="209"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE01008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="334" mass="35560" checksum="3F915F1345D67B4D" modified="2018-12-05" version="1">MVKVGINGFGRIGRNVFRASLNNPNVEIVAINDLTDVSTLAHLLKYDTTHGRLDGTVEVGEGALIVNGKSIKVFAERDPGNLPWASVGAEIVVESTGIFTAKDKAELHLKGGAKKVIISAPATNEDITVVLGVNEDKYDPAQHTIISNASCTTNCLAPFAKVIHEQFGIVKGMMTTIHSYTNDQQVLDLPHKDLRRARAAAENIIPSSTGAAKAVSLVLPELKGKLNGMSFRVPTPNVSVTDLVAEVKNNVTVEEVNAALKAAAEGPLKGILNYSDEPLVSSDYNGDPASSTIDALSTMVVEGNLVKVVSWYDNEWGYSNRVVDLAAFIASKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJJ7</accession>
    <name>A0A398CJJ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YhcN/YlaJ family sporulation lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02873">
        <property type="protein sequence ID" value="RIE02873"/>
        <property type="gene ID" value="D3H35_19820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014247">
        <property type="entry name" value="Spore_lipoprot_YhcN/YlaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019076">
        <property type="entry name" value="Spore_lipoprot_YhcN/YlaJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09580">
        <property type="entry name" value="Spore_YhcN_YlaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02898">
        <property type="entry name" value="spore_YhcN_YlaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017479047" evidence="1">
        <location>
            <begin position="35"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="214" mass="23441" checksum="6C8A00A0FEAB9F72" modified="2018-12-05" version="1">MPWRTPPSFAKGGVRVRKGSVVSSILLSSTLALSLTGCMEKTGDVGNKNIRTNNVKRYDVSNRYYQNESNRMYLADDQANEMNRVSGRGLGNNNVVGMHANSNLELSDAVANKVATIPGIDKAYVMITNRNAYVGVTQKAHGKGAVMDQALKDKIADHVRTVSPTTDNVYVSANPDFMGRMENYAAEVRQGHPIQGFITEFNALVERIFPANSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJP3</accession>
    <name>A0A398CJP3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01058">
        <property type="protein sequence ID" value="RIE01058"/>
        <property type="gene ID" value="D3H35_21755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="74" mass="8424" checksum="CE1FE527040FCB44" modified="2018-12-05" version="1">MWKNDGSYTYLTPDAAYHMDKYSRGYDRMINIWGADHHGYIPRVKAAMAALGNDPDKLTVLIAQMVSLFQNGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJP7</accession>
    <name>A0A398CJP7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02575">
        <property type="protein sequence ID" value="RIE02575"/>
        <property type="gene ID" value="D3H35_17985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017393666" evidence="1">
        <location>
            <begin position="25"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="447" mass="48649" checksum="F1F40E8F4653C70E" modified="2018-12-05" version="1">MSGRSKWIGGLAAVLLAAVVTGCANDKKVELDPETITVLVVDQGTSAAGVKVNELMEKSKAYTEEKNKGLTVNLVKVATDQYLDKIKELKPDVFWIPPSQYRDWDKEIGLLDLTPLMELKGVNVDDYFPESLSAITMDGDKRWGLPIAALNYSIGYSKIWFDNAGLAYPSEDWTWEEFAAAAAKLKEANRDRAPNGYGAMIPLYPDILEPLVLSRGGSLVSPDGTTAAGYLDGEPAAEVIDWLKKLIDDGTIPSLTFGPEMGTAFEKIGAETGMAVSSMPILIEHFKKSGHPDQFGIVNFPKFQDGVRANSPSVTAIAISKNSEHANAAWTYIYESTMEDNPVTREFFGLGLNLSKKVYEKLASTAEPYVSIGYRDLEFAQNGAAARLPEWPAAINANYAQWQSLFNDNADSRKTLKQLASNIDANLAAARTAAEETEPAGEETAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK85</accession>
    <name>A0A398CK85_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_13415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03123">
        <property type="protein sequence ID" value="RIE03123"/>
        <property type="gene ID" value="D3H35_13415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="188"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="294" mass="33837" checksum="151F85FFE41D449E" modified="2018-12-05" version="1">MNGDLEAFRSIVNRYSNALLSVAYSVIGDFHEAQDVTQEVFLKCHHQLHTLQNQARLGSWLYAIAYRTSLDYAKKNKKTVPFDETNSPKSDPVHAWLDRHVVHESLWDALQTLEDKNKSAVVLHYLSDWSMKEIGRFLNLSLSAVESRIRRSRESLKRVLADDFELYFRPHRLGSDFGQAVCEQLLKRMGHFYIPVTNKKQTTDWFVRHFQLGTTARGQLQLESGQLLYLLECAPPFTKTSPGLTFSVSDVEDLWLQLNGDGVSVDPVEVDEWFGKMFVFYDPDGNPYEAVEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKB4</accession>
    <name>A0A398CKB4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4011 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01639">
        <property type="protein sequence ID" value="RIE01639"/>
        <property type="gene ID" value="D3H35_25200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025103">
        <property type="entry name" value="DUF4011"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13195">
        <property type="entry name" value="DUF4011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="221" mass="25716" checksum="AF9939A3039D528E" modified="2018-12-05" version="1">MSGRSVFLIWAKKNRLINYRETKRSNIKIVAPDLVELYRLLILNESALEFPFPFEDDDNDYDDETESYISLGDLQTNQTIKEQQKTLRNLRNKAKTALEEQGVNILYLSFGFLKWRESPDSDRIISSPIVLAPVSLMLESLTSPFVLRMHEDEIVINPTLKYKMEHEFGVILPEFDAHEDSITTYLDNLNKSVIKNKWEVTFETGPKLALLLENKYVRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKJ2</accession>
    <name>A0A398CKJ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-xylosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_12985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01719">
        <property type="protein sequence ID" value="RIE01719"/>
        <property type="gene ID" value="D3H35_12985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gal_mutarotas_2" evidence="3">
        <location>
            <begin position="158"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="775" mass="87531" checksum="DBDA79C9E0F0A6F2" modified="2018-12-05" version="1">MKFTDGYWHMRQGVTFNYPIEIRNVRTTPDKLTVLASCKKIVTRGDTLNTAILTVHYTSPMPDVICVELVHHDGKLPKGPEFAKNIREDVPVQVENGEDEASFTSGKLSVRIHKNEGWSTHFNYDGKRLTGSGYKSPGHIKTQDQSTYMREQLDLGVGEYIYGLGERFTPFVKNGQVVDLWNEDGGTCSEQAYKNVPFYLSSFGYGVFVDHPERVSYEVASEQVSKVQFSVPGESLKYYIIGGASLKEVLHNYTQLTGKPALPPAWSYGLWLTTSFTTSYDEATVNSFIDGMIEREIPLHVFHFDCFWMKEFQWCDFEWDRDVFPDPQGMLNRLKSKGLSICVWINSYIAQQSYLFEEGKANGYLVKTRDGDVWQWDRWQGGMGLVDFTNPAAVRWYKDKLKVLIDMGVDSFKTDFGERIPTDVVYFDGSDPVKMHNYYTHLYNKAVFEVLEETKGKHEAMVFARSATAGGQQYPVHWGGDCTASYNSMAETLRGGLSLGLSGFGFWSHDISGFENTATPDLYKRWTAFGLLSSHSRLHGSQSYRVPWLFDDEASDVLRYFTKLKSTLMPYMFSSSIDTTQTGLPMMRAMVLEFEGDASCEQLDRQYMLGESLLVAPIFNDQGAAKYYLPEGRWTNFLNGSVVEGGRWVFERHDYFSLPLMARPNSLIAVGSNELRPDYDYADGVVIHAFELEDGGEAKAVVYSVKAEQELEVRASRSGSCIDITANGAGKPWELILRGIREAEEVTGAEWTVTDAGIRLVPQAGADKIRVRLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKS2</accession>
    <name>A0A398CKS2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Crp/Fnr family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_08035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03906">
        <property type="protein sequence ID" value="RIE03906"/>
        <property type="gene ID" value="D3H35_08035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00034">
        <property type="entry name" value="HTHCRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="14"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="4">
        <location>
            <begin position="148"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="232" mass="26786" checksum="F69676B0C8DFCCF4" modified="2018-12-05" version="1">MPIDSVMLATSIPFFADIEPELLGRIVPYMREKTFKKGELIFLEGDEGNEIYFVGSGAISIHTFDRSKKVTLAILREGEYFGEMALMKPGLVRSATAQTMQPTLLYSLNRLDFQTLIELDRNLAFHLLNYTMERLRRANQQIYDLTFLSVRTRIIKRLLSWYDESRSDDNGNADRIPHKVTHQQLADLVGAVRETVTKVLQELQDEGLIAIRNKVIHLLQPELLQRKLDEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKZ5</accession>
    <name>A0A398CKZ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000061">
        <property type="protein sequence ID" value="RIE00291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00291">
        <property type="protein sequence ID" value="RIE00291"/>
        <property type="gene ID" value="D3H35_29400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="160" mass="18237" checksum="6F7B35B1528E6D36" modified="2018-12-05" version="1">MSADGKTIAFNSHKSFVPEDTGSSDFDVYWYDWHDPNATKLVWLSGLIENRKYSGTVKVDSSGRYAVFNITLAKQFLYVLRFRQRRTAGTVPEPLMTVPASSPMTLDYITSHSISGDGRYVLFSSQGKIVPGDTDNVTNLFVRDRWSKRRRWSACPTIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL31</accession>
    <name>A0A398CL31_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_11830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03363">
        <property type="protein sequence ID" value="RIE03363"/>
        <property type="gene ID" value="D3H35_11830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="89" mass="9752" checksum="30E22661AF90A206" modified="2018-12-05" version="1">MESVSPLDACAGKETSITPQGIVRRLKTVSLPFLLSLFRLGEDAALALESRGVGTNEHPTWAVTIRWSWKDSTWTISAALAASVLWLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL39</accession>
    <name>A0A398CL39_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_28355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00341">
        <property type="protein sequence ID" value="RIE00341"/>
        <property type="gene ID" value="D3H35_28355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="342" mass="37702" checksum="89415FE192817560" modified="2018-12-05" version="1">MRIEEITGCVWATGLSNMRMKEIAGCGRATRLANMRLDEITTCGRATGLADVRMDEITGWSCATGLSNMRMDEITSCGRTTGLADVRMEEIAGCGWATRLANMRMDEITSCGRTTGLADVRMDEITGWSWATGLSNMRMKEITTCGRATGLADVRMDEITGWSWATGLSNMRMKEIAGCGRATRLAGVRMDEVTSWSWATGLADVRMEEIAGCGWATRLANMRMDEITVWSWATRLADVRMDEITVCGRATDLANMRLDAITSCGRATRLASMRMDEITVWSWATGLSNMRLDEITVWSWATRLASMRIGAFRLPSIIILLSKGTEQVRALLANGVSNPPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL93</accession>
    <name>A0A398CL93_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hemerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_12270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03433">
        <property type="protein sequence ID" value="RIE03433"/>
        <property type="gene ID" value="D3H35_12270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="2">
        <location>
            <begin position="15"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="160" mass="18932" checksum="6F1A7B15797CEF40" modified="2018-12-05" version="1">MPHSNPPMLELYREYDQWKAEHEELQVEVRLLCAYVQRKRSSFDYERWERQHEELDERFRAFMSNWHRLLNKERRAIYPIAKPLTGGRAGPIAVLEQDGQIADLYYAEYVKLSAEGALTDETLTCLHQCLLIVSEHFRIENEVLLPVTEMLMDHIELGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLD8</accession>
    <name>A0A398CLD8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000038">
        <property type="protein sequence ID" value="RIE03235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03235">
        <property type="protein sequence ID" value="RIE03235"/>
        <property type="gene ID" value="D3H35_12730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="64" mass="6871" checksum="74D18E8C94142D1B" modified="2018-12-05" version="1">MVAAQALKPDCAICIDINIAADTPDLKDSNDIALGAGGCKHVQLPWTRYAQRYDSASPYGEMDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLG1</accession>
    <name>A0A398CLG1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase MtaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">mtaB</name>
        <name evidence="12" type="ORF">D3H35_06080</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04186">
        <property type="protein sequence ID" value="RIE04186"/>
        <property type="gene ID" value="D3H35_06080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:N6-threonylcarbomyladenosine methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006467">
        <property type="entry name" value="MiaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034557">
        <property type="entry name" value="ThrcA_tRNA_MEthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00295">
        <property type="entry name" value="threonylcarbamoyladenosine_tRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01579">
        <property type="entry name" value="MiaB-like-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="10">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="140"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="9">
        <location>
            <begin position="372"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE04186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="449" mass="50555" checksum="156BD662B3A2C61B" modified="2018-12-05" version="1">MPSVAFYTLGCKVNFYDTEAMWQLFKNEGYEQVDFETTTADVYVINTCTVTNTGDKKSRQIIRRAVRRNPEAVVAVTGCYAQTSPAEIMAIPGVDLVIGTQDRENLMTHINGVQQNREPVNAVRNIMKTREFEELDVPDFTERTRAFLKIQEGCNNFCTFCIIPWSRGLSRSRKPESVLNQARALVASGYKEIVLTGIHTGGYGDDLENYRLANLLEDLDRIEGLERIRISSIEASQIDDDMIRVLKKSPKMCRHLHIPLQAGDDAILKRMRRKYTTAEFAEKIDRIKAAMPGVAITTDVIVGFPGETDEQFENGYRFMEQIGFSEMHVFPYSKRTGTPAARMDEQVDEELKHERVHKLIDLSERMQAEYGATWVGKVLDVIPEREAKGEEGKGVLSGHTDNYLHVVFKGDSALIGELCRVRVTDSGVNECTGELLEVLSPARLLASNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLJ2</accession>
    <name>A0A398CLJ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02079">
        <property type="protein sequence ID" value="RIE02079"/>
        <property type="gene ID" value="D3H35_15065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="363" mass="42663" checksum="4352BAE53D5942E5" modified="2018-12-05" version="1">MRKKMAYFMHVDWKWIKQRPQFLAEELLAYYDIDLFYIRNMKVRGLIDNPLDEAAFHSVNRIRKLPYSSRSPWVQQAERWINRTSVKRAHETDYDYFWITSPYILHFIDIERIRARNIIYDCMDDILAFPQSEKTRNSLAALEKQLLKQSNLVFASSEHLKSKVEERDAQALVSVANNALSLTLAKSGHIFEPPTEKIERFTITYFGTISHWFDFDLLFKLLELHRDIQITIIGPSEVPLPPHERITYTGSIAHDAIKIFAERSDAFIMPFLVNELILSVDPVKVYEYIAFGKPAFVVEYPETLKFADFVYLYRNAEQLSAIIDRVKRDRTGKNSLDQIDSFLQQNHWGARARHIHQTLENSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLK1</accession>
    <name>A0A398CLK1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">M23 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00511">
        <property type="protein sequence ID" value="RIE00511"/>
        <property type="gene ID" value="D3H35_27575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="1">
        <location>
            <begin position="92"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="197" mass="21028" checksum="D075C69E3AF8FBA8" modified="2018-12-05" version="1">MFAICWGWIRSDIPGGEEARQWTVRAVTQDMDFEAVEAWYGQTFGGSPSFLPSFRGDDPAAEASAGWSRDATVLPVDGRVVQSFAQSDTGIIQIAAPLGSDILAVHAGRVTQVTTDNGGKATIIVQHSNRVMTVYGDISSPVVKTNDWVQAGQKLGVIGAANEDAAAIGDRDGEGTLRFAVKQNNNYLDPAEVIPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMC0</accession>
    <name>A0A398CMC0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferritin</fullName>
            <ecNumber evidence="4">1.16.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_07145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Iron-storage protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>4 Fe(2+) + 6 H2O + O2 = 12 H(+) + 4 iron(III) oxide-hydroxide</text>
            <dbReference type="Rhea" id="RHEA:11972"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:78619"/>
            <dbReference type="EC" id="1.16.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the ferritin family. Prokaryotic subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.2" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04496">
        <property type="protein sequence ID" value="RIE04496"/>
        <property type="gene ID" value="D3H35_07145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01055">
        <property type="entry name" value="Nonheme_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041719">
        <property type="entry name" value="Ferritin_prok"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="PTHR11431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="5">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="168" mass="19669" checksum="057FF0DA7FDDED87" modified="2018-12-05" version="1">MKDTLHEALNEQLNFELYSAHVYLAMAAYCSGESLDGFANFFVVQAEEERFHASKIYKYLNDRGKRVNLTGMSDPLNEYSSILDAFEHAFEHEKEVTRRIYHLSDLALNDREHATIQFLKWFIDEQVEEESMFDSIIHKLKRIDKDSNAFFMLDAEFLQRAFTPPAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMF4</accession>
    <name>A0A398CMF4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_17025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02409">
        <property type="protein sequence ID" value="RIE02409"/>
        <property type="gene ID" value="D3H35_17025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="307"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="586" mass="67488" checksum="E49B2873A3665BFD" modified="2018-12-05" version="1">MLPTIFISLRTKFIVMFFVLITIPFLISGVFTYKQFTSSSENTTKSYALQIMNQIVINLDNDLKSMDKLMIVPFYDDNVMSILKHHSDSNISNPYITTGEFTKMNLFISSLTYDKPEIEGYFLFTEDGGLFSNLIENVRNDWQPDQNEWMDYVKEADGGMVIIPPHQASYYIYRQEMVFSVARLIKEPLTHRPLGVVKIDLTNKLFDRILSTVSLSENSKFFVSDQDGYPYYPSYHNADLQLFESNSKQTKSYHKISLQSSNSKLQILGFLSVSDLQQDANQLVTYTLLISILSLFVACAVAVLSSNRFIKPIHHLQSKMRNVEKGLFSERATVQTKDEIGQLTNGFNNMVQEINNLIEEVYETKDREREAELSTLQSQINPHFLYNTLELINMIALQKQQYMISDIVSSLGKLFRYTVDKKEKPVYLKEEVRFVEAYLQIQSFRYGDRLAYEVDIPMELNYVLVPKLILQPLVENAIEHGISEGEGTVNVKALQRGDELFISIQDSGKGMTVEQIESLEQTIFAKKDTFSEREHFGRERKGYALRNLHQRLRLLYGDSYGINIDKSLKTGCVMTINLPIQVEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMT9</accession>
    <name>A0A398CMT9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_29815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00234">
        <property type="protein sequence ID" value="RIE00234"/>
        <property type="gene ID" value="D3H35_29815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017355021" evidence="2">
        <location>
            <begin position="24"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="317" mass="35720" checksum="5401ECEE957FDA23" modified="2018-12-05" version="1">MRLRSMTIVFLGLVLLTACTSNKANDRPDLQASSTSDASTETASPSPSASESTVGSLNDYWDGQSKRRLLDTAILDEEPPFEYVRFGLTHDNPEVRWYCAYRIGEEPSKIDEADRARLEAMTKDTDGNVRQAAQFTLQVLNGTFEGDAFSHSSDNKTVAFHRYREARYNDGKVWLSRNGDTKVVYYSDASITNLSISPDAAWLAVEYGGRIWGSLELVDMKTAKPLGNTFLLEAVLKDPNGGYTDVDPSQNDRFDPYVRFLEWKSDGTQFLFSYGFWRSADRPEYGTAVYTIKTGTVSRIEKAADERKHQKPENFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMV3</accession>
    <name>A0A398CMV3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell wall hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01237">
        <property type="protein sequence ID" value="RIE01237"/>
        <property type="gene ID" value="D3H35_22860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011105">
        <property type="entry name" value="Cell_wall_hydrolase_SleB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042047">
        <property type="entry name" value="SleB_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07486">
        <property type="entry name" value="Hydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="147" mass="17111" checksum="1955E6E91560D948" modified="2018-12-05" version="1">MAVVKARKQDIDMLARLLRAEAETEGEMGMLLVGNVGINRIRANCSDFKGLRTIPQMINQPHAFEALQHGMYYQNARERERRLAQRAVNGERNWPGKFSLWYFRPGTFENPGPCPPTWYNQPLAGRWKKHCFYEPTAEECENVYNTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMV9</accession>
    <name>A0A398CMV9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04686">
        <property type="protein sequence ID" value="RIE04686"/>
        <property type="gene ID" value="D3H35_04155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="178" mass="19282" checksum="E782770575417D6F" modified="2018-12-05" version="1">MKLRVWPLTVTAALSAALLFGGWFAYRHYGVEQPLDRIAAAVPGVQAATTEMRTGEVVVNVELAPDANLSDVYNRIKNDGQSAIGSKKVELKATAHKSSELLDKAWSHALFDVAEAMENHRYSGVRDAMDKLSQQFGGVTATTSMDEDNVYISLRDGTAAKFVVLPREGAAMGVWPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN69</accession>
    <name>A0A398CN69_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02689">
        <property type="protein sequence ID" value="RIE02689"/>
        <property type="gene ID" value="D3H35_18700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="232" mass="24947" checksum="110742E141EF5ACE" modified="2018-12-05" version="1">MSENNDNQLTDLIIDGVSSSAGGQYRNVKINGVGKVGGELVSRTFAANGHISVQGSLRTEELDCDGKLSVRGSAQVTKGTVDGMAGIEGAFRGEHLILNGLLTVRGDCEIERFEAEGGFTVDGLLSAGTLDVRLHGRGKARDVGVEWIRVRQASKSRWNLLWRWAFPKFSPELLAGTIEGDDIDLEYTIADIVRGNRVVVGKGCVIGRVEYKDHLSVHPDAKVGEEAKSGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNW0</accession>
    <name>A0A398CNW0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05056">
        <property type="protein sequence ID" value="RIE05056"/>
        <property type="gene ID" value="D3H35_02690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="74" mass="8422" checksum="F9AA77FEDFDDD5AF" modified="2018-12-05" version="1">MRNRIDSLFVRAGKLTRWGCSDHSAGTLRLSIEADNRKTKRSGRPGVQYSDKMLDRFDEWESPRPETAAGGRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP48</accession>
    <name>A0A398CP48_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00180</name>
        <name evidence="1" type="ORF">D3H35_07010</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000002">
        <property type="protein sequence ID" value="RIE05479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04343">
        <property type="protein sequence ID" value="RIE04343"/>
        <property type="gene ID" value="D3H35_07010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05479">
        <property type="protein sequence ID" value="RIE05479"/>
        <property type="gene ID" value="D3H35_00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="198" mass="23586" checksum="29A81DFA077D2F40" modified="2018-12-05" version="1">MNRSYEVEYCNLELRFDRRQIQNLLRELIQQGYSLYWNESDHLFTVSVRTGRKLLKLRFQRILNRYKLVGDYLVKDEKLALWIEKLIGDSRGHAIVKRFRDRQILIENIMFGEIIRLVEVSGMEHRIIFQKRPHITVEDMVQAFKSKRAELRAGVLRLEIDYELAVLHEAIQEGRAADAEASKEKLKVMRVEMLLLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPJ2</accession>
    <name>A0A398CPJ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04435">
        <property type="protein sequence ID" value="RIE04435"/>
        <property type="gene ID" value="D3H35_07575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="68" mass="7215" checksum="0E746D2D687164AA" modified="2018-12-05" version="1">MKPIDFFGTVSGSLLPYEATATKTDRDIVAATSSDQQRGDLPSCMDEKGAHKGTFIHQTEGGDELIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPN0</accession>
    <name>A0A398CPN0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asp23/Gls24 family envelope stress response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04372">
        <property type="protein sequence ID" value="RIE04372"/>
        <property type="gene ID" value="D3H35_07205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="126" mass="13501" checksum="6A25DCC11225F8D7" modified="2018-12-05" version="1">MTEQLQQGLIRISDDVVATIAGLAALETSGVAAMSGGISEGLAKRLSGRNAQKGVSVEVGQLEAAIDLRIVVQYGIPIQEVGRRLQENVRDNVENMTGLRVVEVNVKIEGVAFKEEETEEAANRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPQ4</accession>
    <name>A0A398CPQ4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">alr</name>
        <name evidence="7" type="ORF">D3H35_25625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00944">
        <property type="protein sequence ID" value="RIE00944"/>
        <property type="gene ID" value="D3H35_25625"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="6">
        <location>
            <begin position="246"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="393" mass="42499" checksum="CC1272E11BEDEB2A" modified="2018-12-05" version="1">MDCYYRPTVAEVSLDALGRNIGTFRRQIPAGTKLLASVKANAYGHGAAWIAKEAVASGADYLGVAFLDEALQLRNEGITAPILVLGFTPPEGLALARDNGITITLYRDDTLTAAAALPTNGLKLKAHIKIDSGMGRLGLLPGSDAEAFIERACRLPQLEVEGLFTHYAKADEVDKSYMMMQIERFGAVVDYVRRNGLPISIVHAGNSAAGIDLPEHAGQMLRLGISMYGLYPSDEVNRSAVDLEPILSLKTRIVHAKQLQAGEGISYGTRYFTQGNETIGTLPIGYADGFSRMLSGKAEALFRERRVPIVGTICMDQCMVRLSDAWSEGDAPLLPGEEVVLIGRQGEAFITVEEVAARLGTINYELICMLATRVPRLYRKNGEIVGVTNPLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPV5</accession>
    <name>A0A398CPV5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">GTP cyclohydrolase 1 type 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_06265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04220">
        <property type="protein sequence ID" value="RIE04220"/>
        <property type="gene ID" value="D3H35_06265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017221">
        <property type="entry name" value="DUF34/NIF3_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037489">
        <property type="entry name" value="UCP037489_NIF3_YqfO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR037489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="371" mass="40284" checksum="DA4CF34F8D982C7C" modified="2018-12-05" version="1">MFARGETVVQLMEKLAPKHYAVQDDKIGLQVGTLRKEIKKVLIALDVTPEVVDEASALGCELIIAHHAVIYRPLAHLRTDTPAGALASALLRNDIAVYISHTNLDTADGGMNDWMAEALELEGRGVLEEVHTDKLFKLAVFVPETHAEAVRNALFQAGAGWIGNYSHCSFNVPGTGTFLPREGSEPFLGKPGKLEQAAEIRIETVVPDSVRKAVVSAMLKAHPYEEVAYDLYPMDLKGRSFGLGRVGKLASAESLDAFAERVKTALDVPFVRVVGAPDKSIRKVAVLGGSGSRYIRHASFAGADVLVTGDIDYHTAHDALAAGLAIVDPGHNAEKIMKRKVAEWLGNKLKEQKYETEVFASQIATEPFRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPX7</accession>
    <name>A0A398CPX7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">POTRA_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000003">
        <property type="protein sequence ID" value="RIE05466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05466">
        <property type="protein sequence ID" value="RIE05466"/>
        <property type="gene ID" value="D3H35_00290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013685">
        <property type="entry name" value="POTRA_FtsQ_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08478">
        <property type="entry name" value="POTRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POTRA_1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="153" mass="16662" checksum="75E0EB26F926CCB9" modified="2018-12-05" version="1">MKAALAVNVGDSFFVPSSGKLETRVRSLKPVKEASIVKHFPGKLTVKLQEFEEVATELGADGKVQAVLANGLVLPSKQGALPDKPILTGWKTGDANFQALCQTLSQLPDHLLTDLSEIKPDPSKLSRPDQAVYPISLRGCNDCRQAVRKNYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ39</accession>
    <name>A0A398CQ39_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_19855</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02878">
        <property type="protein sequence ID" value="RIE02878"/>
        <property type="gene ID" value="D3H35_19855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="8">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1079"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1192" mass="132018" checksum="F10117C40088B14B" modified="2018-12-05" version="1">MCGFVHLHVHSEYSLLDGAARIKEMTARAAELGMTSLALTDHGVMYGAIPFYKACKERGIKPIIGMEAYISAGSRHEKVSRKEQPIYHLTLLAKNEAGYRNLMKLSSIGHLEGFYYKPRIDFDALKEHAEGLIVLSGCLASELSQLLLAGRYEDAKSTALRYRQLFGDDYYLEIQDHGILDQKKVTADVLRLAEETGIPLVATNDSHYLCEEDSALQDVLICIGTGKTLEDTDRLKMTTTQLYMKSGEEMAALFRHVPEAVANTAAIADKCSLDIDFGRHILPSFSPLPEGKTAAAYLAALCEEGLAARYEGTEEWRDGKFRDTAVNRLRYELDVIGRMGFDDYFLIVWDFIRFARESDIATGPGRGSAAGSLVAYSLRITDVDPLKYKLLFERFLNPERVTMPDIDIDFSDERRDEVIRYVKTKYGSDHVAQIISFGTLAARAAVRDVGRVLNVPYGDVDKAAKLIPGMPGMSIERAAKESTEFRALSEGGGPTGELVAMARRVEGMPRHASTHAAGIVMSPTPLTDYVPLQEGTDGVPLTQYSMEHLEAVGLLKMDFLGLRTLSIIERAMRWIREETGRELRWEDVPYDDPATYALLGRGDTTGIFQMESAGVRKVLKDMKPSTFEDIVSVLALYRPGPMEFIPQFIRAKHGQAEVVFPHPSLEPILADTYGIIVYQEQIMQIASGMAGFSLGEADLLRRAVGKKKREVLDEQREHFVRGSLEQGHGEEAANRVYDLIVRFADYGFCRAHAAAYAVLAFQTAYLRAHYPVPFMASMLTAVIGNQRKTAEYVDDCRKMGIPVLPPDVNESGVLFTPVRGEAIRFGLAAVKNVGTQAIDSLLRERSEQPYDSLTDLCRRVDPRACNKRVVESLLLAGALDTLPGHRAQLLAALDETVEAAAAWRKEKEELQIELFDFGDSPNWIVDLPEVAPFTAQQTLELERELMGLYLSGHPLDAFDGLMDELKLDRLMDMTDAQDGATVLTAGMIVSLKPFVTRKGQQMAFLEMEDRIMGTELVAFPTVWKNASSFVKKGSLVLVRAKVQQGDDDFKLLADDILPLEAPDLTRQVERLRQLRGRISGVDAGARPSREGAGAKPSQDGGLESAATSMEADALEGGMQRVYIRIDSTREQTALLTRLKALLSSHSGPLQAVLIYERGRRTVALSDDLRVRPSPELFGAIEALMGEGSVRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ70</accession>
    <name>A0A398CQ70_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pstC</name>
        <name evidence="11" type="ORF">D3H35_20055</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02908">
        <property type="protein sequence ID" value="RIE02908"/>
        <property type="gene ID" value="D3H35_20055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="74"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE02908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="293" mass="31218" checksum="01EF536CC5F0BD15" modified="2018-12-05" version="1">MKLPKHIREEWWGKSYVFGCVAILIVTIFSIVYFIASKGLSPFVSGGVGIGELLFGLKWNPEGEPATFGALPFLFGSFSTSLIAALIAAPFGFCAAVFMTQIAPKLGRSILQPAIELLAGIPSVVYGFVGLSVVVPFLRDHFPGQGIGVLAGAIVLSVMILPTVTTIATDALSTLPAGLKEGSFALGATRWQTIYKLILPTTLPALLTGIVLGISRAFGEALAVQMVIGNAPHIPRSLFESASTLTSIITLSMGNTVGGSLHNNVLWSLALVLLLMTFVFIFIVRMLERRIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ84</accession>
    <name>A0A398CQ84_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">YitT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_04070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04673">
        <property type="protein sequence ID" value="RIE04673"/>
        <property type="gene ID" value="D3H35_04070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006483">
        <property type="entry name" value="Membrane_protein_YitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="229"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="289" mass="32037" checksum="B0671B7968E4B8D7" modified="2018-12-05" version="1">MSSDDFWRKVRTWATLAAGTAVYAFGIQYFILPNRLMEGGVTGVAVLLNYAGNLPTSLMTLVINLPLFALGWRRLGKSAMVYTVGGTVLLSIFLWILERLFQHGYIEPFRTEQDFILVVLYAGVTLGVGLGLVFRVGGTTGGVDIIARILHRAKGWSMGQIILSLDVLILGISLFFIPKEKVLYTLVTVFIASKIIDFIQEGAYAAKAFTIVCESPDRLAKEITRELDRGVTLMPARGGFSGEPKTVVYCVVSRFEIPKLKSLVRQHDKRAFIVINDVHDVLGEGFREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQL4</accession>
    <name>A0A398CQL4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04782">
        <property type="protein sequence ID" value="RIE04782"/>
        <property type="gene ID" value="D3H35_04710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FtsJ" evidence="1">
        <location>
            <begin position="181"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="341" mass="37822" checksum="918E863132D7D89B" modified="2018-12-05" version="1">MTTYIGTANPGFAPYAMEELRKRIPGSAVSGLAPGETFRFTSGGMDDAALLKELRRDEPVFLRHLFPIEAEAQLTSDPASTADSLRRYAETLADRVKGRKIAVQVRKSHGSPFPFTSVEGRDFVAEVIREAGAELVAREADLIVSVYAAHKTLYTGCSAPKDNLSDWPGGAVRFRREEGLISRAAFKLLEAEQAFRLPLDKFTNALDLGAAPGGWTSVLLERGLKVTAVDPAQLDPALEDHPMLRHIQKNASEISFSPGTFDLLVCDMSWDPYNTCRLVSELASSMTAGASGIITLKLMYRKPFNTLQELSRAYGEVFDIRRIKQLFHNREEVTMWVRRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQP4</accession>
    <name>A0A398CQP4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_04970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04822">
        <property type="protein sequence ID" value="RIE04822"/>
        <property type="gene ID" value="D3H35_04970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="21"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="297"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="391" mass="41575" checksum="82204D28C63F366B" modified="2018-12-05" version="1">MNFMQGFKMALKSILSNKLRSLLTMLGIIIGVTAVIALVSLGQGATKSVQEQVQGLGTNLLTVNITGRGASNSLSIEDVNGLSSISGIQYISPTSSSNASIKYDSKTEDSVSVVGTNTDYMKVRGYELASGRFLSQIDLDFRQKVAVLGSDTATSLFGFSNPVGEYILVNGNRYKVVGLLASKGSTTNGSNDEVVMIPFTAAERLFKSKGARTVYVQVEKDDQIDKVVTELETALSKKFRGSTNSYRVFNQSDILETLSSVSDTLTLALAGIASISLLVGGIGIMNIMLVSVTERTREIGIRKAIGAKKRDILVQFLIESMVLSGLGGLLGIGIGMGAAKVASATLDMGIEFSMQIIVIAFVFSVVIGVVFGMFPANKAAKLKPIEALRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQR2</accession>
    <name>A0A398CQR2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gmk</name>
        <name evidence="11" type="ORF">D3H35_07315</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04500">
        <property type="protein sequence ID" value="RIE04500"/>
        <property type="gene ID" value="D3H35_07315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="4"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE04500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="210" mass="23734" checksum="F329C97DC22392AC" modified="2018-12-05" version="1">MNRGLLIVLSGPSGVGKGTVCTALRGKLPELIYSVSATSRQPREGERDGVNYFFKTREQFQDMIARDALLEHAEYVGNYYGTPREFVEKTLAEGKDIILEIEVQGAIKVKEKFPEGVFVFLLPPSLNELRQRIVGRGTETQATIDHRLSVAIEEMNLLYHYDYAVVNDQIDSACSRISSIITAEHCKRERFLHELFQELKPITAGENAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR59</accession>
    <name>A0A398CR59_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">map</name>
        <name evidence="5" type="ORF">D3H35_02350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05012">
        <property type="protein sequence ID" value="RIE05012"/>
        <property type="gene ID" value="D3H35_02350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="12"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="251" mass="27411" checksum="890D0DEFF2760CF5" modified="2018-12-05" version="1">MIVCKSETELNLMREAGRIVAETHRLMKEAVVPGVTTAELDRIAEAYIRSQGAVPSFKGYNGFPASICASTNEELVHGFPGPRKLMEGDIISIDIGAQYKGYHGDSAWTYGVGTISEEAQRLLDVTEASLYAGLELVRPDVRLFTVSHGIQKVIEEAGFSVVREYVGHGIGSNLHEEPQIPNYGVPDRGPRLKAGMTLAIEPMVIVGDRKVKTLADKWTVVTVDGSLCAHFEHTVAVTEDGYEILTRAEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRB8</accession>
    <name>A0A398CRB8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">rbfA</name>
        <name evidence="2" type="ORF">D3H35_11610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03328">
        <property type="protein sequence ID" value="RIE03328"/>
        <property type="gene ID" value="D3H35_11610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020053">
        <property type="entry name" value="Ribosome-bd_factorA_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01319">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="118" mass="13426" checksum="1BBD691B77B61675" modified="2018-12-05" version="1">MAKFRVGRVGEQIKKEISSIIQTELKDPRIGFITVTGVDVTNDLSLARVYLSILGNDEQKEETLKAIGRANGFLRSELGRRVRLRHTPVMEFRFDSSIEYGSHIEALLAQINKESREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRJ1</accession>
    <name>A0A398CRJ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_04645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04770">
        <property type="protein sequence ID" value="RIE04770"/>
        <property type="gene ID" value="D3H35_04645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="177" mass="20849" checksum="725F4391FA5C91D5" modified="2018-12-05" version="1">MSRSWERMVQKNSKSINNRRRKEGKDAIGSTSKVKPDRYQGRNYYVPALLLLLILFYVVMLQPWREPKAGEPTPDLTMTWVTVGCYVLLAVFYWFRRPYLAVTRDTLETRKFSGYKRLGPADIRKIVLMPGYVTVETVKGANWVFSRMMTRYPTEQMGERLKVFSEVNHIELEIKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRN5</accession>
    <name>A0A398CRN5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D3H35_05025</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04830">
        <property type="protein sequence ID" value="RIE04830"/>
        <property type="gene ID" value="D3H35_05025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="325"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="11">
        <location>
            <begin position="391"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="12">
        <location>
            <begin position="465"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="656"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE04830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="994" mass="111601" checksum="A2407E978743EF38" modified="2018-12-05" version="1">MLAFLAIICLFCMKMTLTTWEEAMFRSLRFKLIVVLLALHGVSFSLMAYFNYQMSTKKLTDEMERNMKGNLTTAARNLDDWLNLRQTEGSLLARSDNIRTGTTEDKLAYLRQLTSRTMEYVRIGIGDRTGKMRLTDGSTIEMNGMFAYRAALNGVSNIADPLKKSKPDEPNLLWTFVPIFDLSRQVSGVLGLALDSDAALKQHLYFDSFDYKDFTITLLDRSTTLLYHSNEPDLIGYNYHANTPNSNALFDLIQKQNYGHGDQFIRGRVQKVYFAHVPNTNWIITYSVNRAEFMHPLRSSLSWTLALVALTELLLGILLFVASDVIMMKRLKRILSQTEKVASGDLQLSPLPTGSRDELGAISVSVNRMTENLRDLFEPFNTFIKHNDFAMLVVDTRFVITSFNDRAVQLLGYSAAEVIGTRSLLRWHDPDQIKERARSYSEKLGTHVPNDENALFVLSQRGYLPEWEWIWINRDGARIPVSLNTSIMKNSDGSTKGYVVIARDVTEIKSAADTNVRLLEILESAHDMIASFDFRGRIFYLNQQGRKFMDILELNEHTELLSRYMNVTTTFQFANGLKSARDKGFWQGEVEMVRADGLSFMTSMIVVAHAPKDGGEPFFSTIVRDISAQKEIEREIVHAKHAADEANEAKSSFLARMSHEIRTPLSGIIGLTQLLRRSELSELQHEYLEQIGLSSQSLLQMLNEVLDFSKLEADKLSIEKVPFLPEESLQRLTATFAVLLGSNPVDFIVNVDPKLPAAWIGDPSRLEQVLLNLGSNAVKFTKQGVIELRIEPAPFTQDSGNNEEEIRVRFTVSDTGIGMTGEQITRLFQPFVQADDKTSRKYGGTGLGLVICKALIENMGGTISVHSEYGAGSSFPSTFLLACPKAVRLRKRRLPSRSGSKCSCSRTTPECSNIGAACWNRSDAKSQRPSVGEIPSPCWRAGLGTSCLSIWKPEICTEKKRGSSGNGSRIREACASCRSRRSRGATRCFACRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRY7</accession>
    <name>A0A398CRY7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_24745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01694">
        <property type="protein sequence ID" value="RIE01694"/>
        <property type="gene ID" value="D3H35_24745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="518" mass="60330" checksum="22A37EEF5089D6E2" modified="2018-12-05" version="1">MFNQKQRYRFSDAPIWALQRQYYEEEGLKAWNNDQVPQYITSNPMIAIAYAEMIFGLLQDRANKGYGSEPVMIVELGAGAGRFAYHVLRELSRLRDYAGIALPAFQYVMTDLAMNNVRAWKEHPALQAFIAEGILDFSRFDAMHDTSLHLELSDVMIRQGDLQQPLVIVANYFFDSIPQELLYIGDGQVYEADVYVEYPEHHDLLKPSELLNQIVLSYEHRRAAEYEQETYPYRDVIAVYKEQLEDSHILFPVAGLNCLERLNKLSQHGFLLVTADKGYHLLDSWKFAEPPELILHGSFSLTANYHAIQYVFEQRGAAALFPPHHFKNINVGCILNLEQPMDYAQTRLAYRRFIERFGPDEFFSMKVWVDRNLESMDLQQILSFWRLGGYDAEFFIQSTKRISGLMSDVNDEERQDLLTGIQQMWSSYYVMEQRYDLALDAGLVLFEMSMYEESKRFLEISILEEQDEVVSTVYYCLAICCFELELFKEASHYLRELLVLDPGHEEAMALLRINTESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS03</accession>
    <name>A0A398CS03_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_17995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02577">
        <property type="protein sequence ID" value="RIE02577"/>
        <property type="gene ID" value="D3H35_17995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="110" mass="11746" checksum="747965A5DC79A052" modified="2018-12-05" version="1">MNIVTTESGGVTVMAIEGRLDGIHASEAESAFLKLAAEGRSRFVLDFKDMVYISSAGLRVVLVAAKKVRSLQGRLICAGMSDQVRDVFEMSGFLSILETAAGTDEALSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS20</accession>
    <name>A0A398CS20_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Deoxyribodipyrimidine photo-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_08680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA photolyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04019">
        <property type="protein sequence ID" value="RIE04019"/>
        <property type="gene ID" value="D3H35_08680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="PTHR11455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="SSF52425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="5">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="447" mass="51721" checksum="D2F852EE692542AF" modified="2018-12-05" version="1">MKLFIHRKDLRTHDLPAFDYLKAGGEAATLHALILDPFLLRDDRHKEHSGIHFLRQAGRLREEYARFGATLAVYAGEPGEVLEHILTANPAVDEVVTHEDFTPYALRRDRTMLEIAKSAGVRFTSLSDLPLVRLRDFHEWTGREEGYRVFTPFYRKWREFLDMDNVSSYTIGLRDLKTAHSIALGERYRVPAEWEAIMDQGRATENPEQTLAAFADERLVDYSKSRDSFAQNATSRIGRFLNVGALSARSAYECVVAAGNHSEGWLRQLAWRDFYLYQSRMDPDFFRYESLFDLSSLDDRHFRAWAEARTGIPIIDAAMTELNETGWMPNRLRMVTAMFLTKNLGCPFVFGERYFRRKLEDYDNTLNRGGWLWSSSLGFDAAPYFRIMNPVTQSETHDPSGSYIRKWLPELAKLDDKRIHQLRPHAIVDLKTSRAAAIETYRSLLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS86</accession>
    <name>A0A398CS86_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_16025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02241">
        <property type="protein sequence ID" value="RIE02241"/>
        <property type="gene ID" value="D3H35_16025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="327" mass="34834" checksum="B061653F535478E5" modified="2018-12-05" version="1">MFRQWMVILVAAALLATVAVLSAMTGSIKVGFGELVQGLLFGNNEQVEIIRDLRFPRIFVSMLAGAALAVSGVLLQAVMKNPLAEPGIIGISSGAGFVSITVVTLFPMLYFWSPLFSVLGGAFACWLVYSLSWRTNLNPLRLILVGIAINATFTGLGQSFNYRGSYAVTSVNQAISSIFTMKTWEDVYILGLFGGIGLFCSLFLSPWCNLLAFSDETARNLGLRIVRVRLVISAAAVLLASVATAIGGLIMFVGLLVPHIGRVLVGSNYKVLIPFSAVGGALLILTADTVGRTVLAPAEIPASILMAVIGGPFLIFILKRSDNVRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS99</accession>
    <name>A0A398CS99_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00950</name>
        <name evidence="1" type="ORF">D3H35_03305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04980">
        <property type="protein sequence ID" value="RIE04980"/>
        <property type="gene ID" value="D3H35_03305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05402">
        <property type="protein sequence ID" value="RIE05402"/>
        <property type="gene ID" value="D3H35_00950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="46" mass="5672" checksum="EDD2455F6BE3A1C2" modified="2018-12-05" version="1">MPPKSNTATPWECDFYHYEERHVVECFFNKLKQFRGIATRYDKHNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSI3</accession>
    <name>A0A398CSI3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine kinase</fullName>
            <ecNumber evidence="1">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_00075</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000001">
        <property type="protein sequence ID" value="RIE05492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05492">
        <property type="protein sequence ID" value="RIE05492"/>
        <property type="gene ID" value="D3H35_00075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="61"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE05492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="320" mass="35881" checksum="9F7CE1184DC321D9" modified="2018-12-05" version="1">MRFVRNSKWEWTLYTGAISLAMALFFAWTETSDSPIEGKDWYGWAAGLIVLAMAVGYVLGRRTQQRIDQLQLAIKQAAAGNWTAKLPSLGMDAFAGVFLDFNAMLSALESRLKLLQQLGEKSVEEVSSQENAVLEERRRLARDLHDTVSQQLFALHMSASSLPKLLERDAEHAAKVMEQLIAMSSTAQRQMRSLIAQLRPLELQGRTLEEALDRWFPDYCRQNGLQGTLDIQLRSPVSEAMEHQLFLIIQEAMANVVKHAEAKVVRLFLGETDRQLSLNIEDDGAGFRRRGDNRIPKASTGPMAVHMGSEPKSLAEKPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTA5</accession>
    <name>A0A398CTA5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_08555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03998">
        <property type="protein sequence ID" value="RIE03998"/>
        <property type="gene ID" value="D3H35_08555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="203"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="308" mass="36443" checksum="951A9E4809807678" modified="2018-12-05" version="1">MYPEMRYEHVVYQNPFLAMRIWQIDSQNQASEETLRRLQQDWRQKRYFDWHYHEEVELVLILEGELTAFFREERQTLCAGDVALFGSSEPHMTLQVKDETLSYIVLQIDLRKYWDPSTLNSMQHFSEVIRPLSCLNYIYMDNEDARTQTADLICEIYKEMNDEQIGYELAVSSRIKNILLLLLRNDTRMQLNYNNNRLLERLQPAIDFVEEHLGEKLSVAEISGLVNMSYTHFVKTFKKAVGMSFTDFVVFKRIKKAEQQLLTNDEASIAEVAESVGISNIGHFYDMFRRFNDCSPKQFKDRLRSPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTB2</accession>
    <name>A0A398CTB2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RHS repeat-associated core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02551">
        <property type="protein sequence ID" value="RIE02551"/>
        <property type="gene ID" value="D3H35_17835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="99" mass="11825" checksum="C1EBCE9590C679C4" modified="2018-12-05" version="1">MRRVRKHHEQTGTSNNSIRYAGYQYDEENKLYYLNARYYDPKIARFLSEDTYRGQADDPLSLNLYSYAHNEPIKYTDPTGHWIESDSTLSAISRWLFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTH1</accession>
    <name>A0A398CTH1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03137">
        <property type="protein sequence ID" value="RIE03137"/>
        <property type="gene ID" value="D3H35_14775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06533">
        <property type="entry name" value="Glyco_transf_WecG_TagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004629">
        <property type="entry name" value="WecG_TagA_CpsF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34136">
        <property type="entry name" value="PTHR34136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03808">
        <property type="entry name" value="Glyco_tran_WecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00696">
        <property type="entry name" value="wecG_tagA_cpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="236" mass="26612" checksum="D10CB128DDA2AF9D" modified="2018-12-05" version="1">MNMKETVDYLTQAIADRKSHRIVTGNPIMLMAGLENPAFHRALRTADLVVPDGAGVVWAARHVGQPVQERVAGFDLMHELLRAGDRRGWSVFMLGASPDVIVTARDKLQRQFPGIRFAGCRDGYFKDSDDEEVVREIREANPDILLLARSLNTQEPWLEKYQEALQVPVMMGVGGSFDVVAGKLKRAPALFRKLGLEWFYRLLQEPSRYKRMLVLPRFALKVIKDGDKVLKPGDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTK7</accession>
    <name>A0A398CTK7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_18485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03187">
        <property type="protein sequence ID" value="RIE03187"/>
        <property type="gene ID" value="D3H35_18485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SH3b" evidence="1">
        <location>
            <begin position="147"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="233"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="564" mass="62796" checksum="012E3D1E1138D5E6" modified="2018-12-05" version="1">MFLLFVMAAGAAWWLSANLPNSEHTTPDYRSKPSAIMIRGEWTGAYARGDGEGIRLPLEVAQKLLGDGVRYESGTESIILTTDTGVLHFKTGDLDATLNRKPFTLRFSAEKVDGKLYLPLAPLKELFGVRSEVEDGTGIVTLLMPDSTIPRVSVKEGKKKGAKLRSGPDKSYPIVEDLEPGAALRAWSESKDEDNGWYRVQAKSGQIGFVSPKDVEPLEAEKVSSAGKNDQDKPFVAWKTEGQRINLTWEAIYSVQPDTKEIGELKGVNVVSPTWFELLDGTGTIRSKADAGYSAWARAKGIQVWGLFNNSFDPDRTTQALASYESRFRMIQQLSAYAKTFRLQGINIDFENVKTSDKDNLVQFVREMTPILHEQGLVVSIDVTPKSSSEMWSLFLDRARLGQVVDFMMLMAYDEHWASSPVAGSVSSLPWAENSVKRLLEEEDVPSEKLILGIPFYAREWTETPDGQGGVKVSSKAYGMDAIAKTIKSKKLTPTVDEETGQHYVEYKDKDVVKKIWLEDDKSIQARAELVKKYNLAGIASWSRSFASEDIWALLDKHLQSGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTQ1</accession>
    <name>A0A398CTQ1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purK</name>
        <name evidence="7" type="ORF">D3H35_16640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02344">
        <property type="protein sequence ID" value="RIE02344"/>
        <property type="gene ID" value="D3H35_16640"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="136"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="177"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="209"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="294"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="409" mass="44290" checksum="7E1FDD95BC4C3D37" modified="2018-12-05" version="1">MSGIERLDGLFEGGEICTDEGCAVPAPSKKILPGSTIGILGGGQLGRMLAHAGSRMGYRFVTLDPTPDSPCGQTAEQIVADYDSREAALELARRSDVITYEFENVNADVASMLEKESYVPQGSALLYTTQHRLREKRAIEAAGARVAPYAEIASLEGLREAAARLGLPAVLKTATGGYDGKGQWVLRSEADLEKAWPEASRTGTELVLEKFIVFDKEISVIAARRPSGEIRTFPPAENEHVDNILHLSIVPARIPGSVRAEAERMAISIAETLGVVGLIAVEMFLASDGTLFVNELAPRPHNSGHYTMEACRTSQFEQHIRAICDLPLGDTALMTPVVMVNLLGEHMDTLMDRIATGCNEAEKLGVTPKLHLYGKAEAKNKRKMGHFNVLAGSVDAALAWIEESIIWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTT1</accession>
    <name>A0A398CTT1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02721">
        <property type="protein sequence ID" value="RIE02721"/>
        <property type="gene ID" value="D3H35_18910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="207" mass="23327" checksum="3F579B3F9C507DB6" modified="2018-12-05" version="1">MHLYVIRHGQSTMNIGQGGGANCDLSEIGYWQAEQIPSFFQNIRIKAIYSSPLRRAIHSALPLSRFCGLPVILVPEMSEMFLEQWTDYRDYEWKSCSEIVSDYSDVRFLHTHDANKPWWPVWPEIPSGVRARVRSFYDAHIAPDLDTDEHIVVFGHGQSTADLKQIANPGDTIPVYNAGIVEFIMNSAGKCESAVVHTDHLGAHVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU62</accession>
    <name>A0A398CU62_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LTA synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_12035</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the LTA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03397">
        <property type="protein sequence ID" value="RIE03397"/>
        <property type="gene ID" value="D3H35_12035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012160">
        <property type="entry name" value="LtaS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005091">
        <property type="entry name" value="Mmb_sulf_HI1246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="9">
        <location>
            <begin position="258"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="641" mass="71789" checksum="4DB7D432205487AD" modified="2018-12-05" version="1">MERLPLHNQANQSPPTERNRRFRVQGAPLYSFTILLLLKMLLLRYFFFEGVAWGRLGSDLAAIVVLLCVAELLTPVRSKRIVFWIVNLIVSLLLFSSSVYFAHFGSVPTYTALMELNQVAGIKDSVKATIELSHYLFFADIVLALVGAILLRLNNRKLPAARAVWKKGTIVAGILGIVFSALFIKSGLQIDNELAAAENQGFINYEISAAIKSKQESIAVSDETPASLTEQIEQLKATYPYTVPSEKPPVYFGTQKGRNVIVIQMEAFQNFPINLSIGGQEVTPVLNGLMKESFYFPHVFQQIGQGNTSDAEFMSNTSIYPTGKVAMSTGYGDRELPSLPRLLESRGYEADTFHVNEVTFWDRNKLYPALHFDHYFDKPYYTNDNFNGFGASDEELYRVGVEKLTEVAKTGKPFYAQFVTVSSHFPFDVPKDRQRIELPDSLKGTQLGKYIAAVNYTDYAIGTLIDRLKANGLWDNTVLVAYGDHFGLQPKDNDAAMVSKELGITYEPNVSRFNVPLLIRVPGEKNGKVIDRVGGQLDIMPTLANLLGVSLKEDKYTAFGQDLLNIDRNVLGMRYYLPTGSFFNDDVLFIPGKSFDDGKAISLKTLQPVSDIAQYRSDYDYVMKLMTLSDQYVQVLPKRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVG2</accession>
    <name>A0A398CVG2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_08040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EamA transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03907">
        <property type="protein sequence ID" value="RIE03907"/>
        <property type="gene ID" value="D3H35_08040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="21"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="159" mass="16365" checksum="D7CFAC1A556652B7" modified="2018-12-05" version="1">MNECPAKNKATKQKGGNVPVWLVYALLSAATAALVAVFGKIGLKDIDSNSATAVRSVIMALFLLGVVVVQGKAGQLGDVFAHRKAFLFVLLSGIAGALSWLFYFMALKSGKVSQVGPIDKLSVVIAVALAVLFLGEKISAINGIGVALIAVGAILVAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVI4</accession>
    <name>A0A398CVI4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class D sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_05445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04538">
        <property type="protein sequence ID" value="RIE04538"/>
        <property type="gene ID" value="D3H35_05445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06166">
        <property type="entry name" value="Sortase_D_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042000">
        <property type="entry name" value="Sortase_D_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017434300" evidence="3">
        <location>
            <begin position="19"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="224" mass="24324" checksum="666610078B243159" modified="2018-12-05" version="1">MALLKSRKTLIVIWFMLAAGAVLALYPRANEIAQDRRELKLLAEWADTVGNRPRPIQPADASTAASANDSRRLDRPEWTVVDGLQLLGTLRIDKIGLEEPIVRGSDAKALKRGAGTVVEGPLPGEPGNFVLAGHRSLTFGRHFNRLAELKAGDEIVVETSAGPARYKVSTTSIVSPDDLTVLDNDGATSELTLITCHPRKNPTHRLIVKAILVNSIEKEEKPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVK9</accession>
    <name>A0A398CVK9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000038">
        <property type="protein sequence ID" value="RIE03251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03251">
        <property type="protein sequence ID" value="RIE03251"/>
        <property type="gene ID" value="D3H35_12820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="194" mass="21743" checksum="6B9DDFC0239841E6" modified="2018-12-05" version="1">MPKYAVLTNDLQYDLVNKNEERQVAVKEFLPGLISFLKELRELEVPIFHLQLIYLEDDPRAERYNGVLPVTRGSEGAKILAEALEDTDIVLEKNKDSGFYGTDLEERLRNLGVDTIIITGMQTQICVQTTAADGFFRGFNVVVPPDGVVSARAEDKQRALDWLGSYCARILTNAEIIEAIKQNADISFEVVPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW25</accession>
    <name>A0A398CW25_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartyl-phosphate phosphatase Spo0E family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04087">
        <property type="protein sequence ID" value="RIE04087"/>
        <property type="gene ID" value="D3H35_09085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043937">
        <property type="term" value="P:regulation of sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018540">
        <property type="entry name" value="Spo0E-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037208">
        <property type="entry name" value="Spo0E-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09388">
        <property type="entry name" value="SpoOE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140500">
        <property type="entry name" value="SSF140500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="91" mass="10122" checksum="A47FB3B154A831EA" modified="2018-12-05" version="1">MDAAEHNTTANEFAGAHVISSSSDRSDANVGGFYSSDFRLSEEIDRLRSIMTDMFLKEASLTADSVIHISRQLDIKINEYMAHSVRGKQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWE4</accession>
    <name>A0A398CWE4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spore cortex-lytic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sleB</name>
        <name evidence="8" type="ORF">D3H35_11705</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SleB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03344">
        <property type="protein sequence ID" value="RIE03344"/>
        <property type="gene ID" value="D3H35_11705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011105">
        <property type="entry name" value="Cell_wall_hydrolase_SleB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042047">
        <property type="entry name" value="SleB_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014224">
        <property type="entry name" value="Spore_cortex_SleB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07486">
        <property type="entry name" value="Hydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02869">
        <property type="entry name" value="spore_SleB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0309">Germination</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="PG_binding_1" evidence="6">
        <location>
            <begin position="42"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrolase_2" evidence="7">
        <location>
            <begin position="160"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="259" mass="28035" checksum="4ADAD30A138FAC1B" modified="2018-12-05" version="1">MSYRLVILTICLVFGLLGLYTLQHSGISRETFGTTTLKQGASGKDIYELQGRLKHLGFYSGKVDGDFGPTTLNSVKWFQWKFGMKADGVVGAKTKLKLWQASKNWKPTAAELPGGAAAGTGAAGGAPPANDNKLPAANKLGFSEKELKIMANAVYGESRGEAYEGQVAVAAVILNRVKSSEFPNTPTGVIFQPGAFTAVADGQIYLEPNESARKAVNDAINGWDPSDGCLYYFNPETATSKWIWTRPQYKKIGKHIFCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWP9</accession>
    <name>A0A398CWP9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03444">
        <property type="protein sequence ID" value="RIE03444"/>
        <property type="gene ID" value="D3H35_12350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="176"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="282" mass="31565" checksum="FAFB0B817D6F95D6" modified="2018-12-05" version="1">MAEYQYNPFRPAETPARLHLLFWGKEACSPGHAVGPGVRDVYKIHFVHDGKGKVRVGGQTYSLVAGQGFLIVPNVVYYYEADEAEPWTYSWIGFAGTDVAALLERTVITADRPVFTMDKKTMPALYEQLTLSSTASVARDLRLQAHFYEFLAAWIEISAKVSSAAALPGRQEEYVHRTLECLRSHYSDNISIEQIAESLGLDRKYLSAIFKKALDVPPMQYLLRYRMDKACELLGGGTLTVGEVARSVGYRDPLLFSRMFHKVKGVSPSVYRANATKTDINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX12</accession>
    <name>A0A398CX12_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE family efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03544">
        <property type="protein sequence ID" value="RIE03544"/>
        <property type="gene ID" value="D3H35_10880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="460" mass="49661" checksum="52A0D5A828456500" modified="2018-12-05" version="1">MKSLDSSKDKYGLWTLAWPIFIEVFLQTLLGTVDTIMVSRISDDAVGVVGLAGQLFGALTTLFMTIAGGAGILIAQKLGSKRGEDARTIGIMGVTASTAIGAAISVLLAAQPAFFGRLLNLSDELLPLWNVYVSNIGGGLFLTAMIAALGTAVRNTGNTKAPMFTGIGMNALHIALNYLLIFGAFGFPEWGLFGVTVSGNISRLIAAAVLLYVFLYSFDRPIRLADFRVFDRKLFSEIFQIGWPLGVNMSGWVFSQLAIYAFLAMLGAQELAARTYMNTLESFCFMLGYAFALACQIRTAHLFGAARTKEAYSGAFRALYIGLAVVTGNALLLFAVGKQLLGFFTSDPAIVSMGVSLLALNLLLQPAKMLNMALGDALNAVGDTRFTMYIAIFSMSIIATGCSYWLGIHAGWGLIGIYCCMIADELVRGFLVLQRWRGRKYLLKAERTRQLETTEAALSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXK3</accession>
    <name>A0A398CXK3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_05745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000026">
        <property type="protein sequence ID" value="RIE04507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04507">
        <property type="protein sequence ID" value="RIE04507"/>
        <property type="gene ID" value="D3H35_05745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="88" mass="9728" checksum="E10BD0F0EC0B6439" modified="2018-12-05" version="1">MPFSQIELPEVHSPANAIIVANQIAPPRRSGGLNELLLDLLLISAADNSFPPTKHKMEIFVPRNSVICPYNKTVPESEITRLQDRPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXR8</accession>
    <name>A0A398CXR8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_05595</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. EmrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04587">
        <property type="protein sequence ID" value="RIE04587"/>
        <property type="gene ID" value="D3H35_05595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="1"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="503" mass="54115" checksum="199EE80E5B6489B4" modified="2018-12-05" version="1">MALGLLMSSLDNTIVSASVNKVLSDIGGVEQVTWIFTAYMLAATSTMLIYGKLSDMFGRKRFYLIGIGVFLLGSALCGTAQSIDQLIFYRVVQGIGSGAIFPISFSIIFTMFADPKSAAKVSGMFGAVFGLSSVAGPQLGTWISDTLGWRWCFYVNLPIGIASFLVLLVALQESRADRKPKIDYLGAVLIIVSTVSLMLALEWGGNGKYEWSSWQLIGLFALAAASAVLFVFVEKRAAEPMLPLTIFRSRMVSGTSFVVFCQGAIMFSAITYLPLLATYVFGKENSNGLLTPMMASLITGAILSGFLQSFFKFRTLMFASMSLGIVAALLLMKVSYSNPYWEIVCIMVLLGLGVVGPLMSVSQNSVASSVDPRYIGVSSSIVGFWRSIGGVVGASIMAVIVNGYMRESVKTAATEFQLSANPNPAQDPLNYESVFRFKDHFDPQLVTFYGHEMGHAINKGFILALCVMIAGAIVALTVGPMKLQKKSEGDVPSPEAASPSHMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXV7</accession>
    <name>A0A398CXV7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">der</name>
        <name evidence="11" type="ORF">D3H35_03805</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04627">
        <property type="protein sequence ID" value="RIE04627"/>
        <property type="gene ID" value="D3H35_03805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="4"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="177"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="57"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="120"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="183"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="230"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="295"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE04627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="440" mass="49043" checksum="45626EDF1A7F6CB4" modified="2018-12-05" version="1">MARPVIAIVGRPNVGKSTIFNRIIGDRLAIVEDKPGVTRDRIYGTGEWNGRSFSVIDTGGIEIDGEDELLRLVRIQAELAIEEADVIVFMVDAKAGITNADEEVTRMLFRSGKPVVVAVNKVDNLQRMDDIYEFYGLGFGDPVAISGAHGTGIGDLLDAAVFKLPEKEDQTYDEDVIKVAVIGRPNVGKSSLVNAILGEERVIVSNVAGTTRDAIDTPFEKDGQRYVLIDTAGMRKRGKVYETTEKYSVMRSMKAIERADVVLVVINGEEGIIDQDKHIAGYAHENGKASVFVVNKWDAVEKDDKTMQHFSNSIRDHFMFMHYAPIVFLSAMTKSRLSKLLPVVNHVAEQHALRVPTHLLNDIIADAVAVTPPPTDKGRRLRVNYATQVSVKPPTILIFVNDPELMHFSYERYLENKIRASFDFEGTPLRLFTRRKSDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYX1</accession>
    <name>A0A398CYX1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl-CoA_dh_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05037">
        <property type="protein sequence ID" value="RIE05037"/>
        <property type="gene ID" value="D3H35_02560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="1">
        <location>
            <begin position="17"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="153" mass="16566" checksum="4E41C7207023B850" modified="2018-12-05" version="1">MLLTEEQRRQVERLELTEWQHGLLLQVRELGRSVIGPAAKRVDRDGDYPREAIEALKRSGLTALAVPQAAGGFGAGFRGDVLALPLVLMEIASWCSSASQVLALHNSGVQYIHALGTRLRQTFSSRRYGKARCSAASAARIGPTARAPDCAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYZ2</accession>
    <name>A0A398CYZ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YqeG family HAD IIIA-type phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04154">
        <property type="protein sequence ID" value="RIE04154"/>
        <property type="gene ID" value="D3H35_05875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027706">
        <property type="entry name" value="PGP_Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010021">
        <property type="entry name" value="PGPP1/Gep4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF25">
        <property type="entry name" value="PTHR19288:SF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09419">
        <property type="entry name" value="PGP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01668">
        <property type="entry name" value="YqeG_hyp_ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="176" mass="19384" checksum="2828159204FDA345" modified="2018-12-05" version="1">MFERLLPDQIVNTVFDIDLNALKSQGVRGIITDLDNTLVSAKTALATPELIAWLDRVEKAGFKVVILSNNNGSRVSKFAEPLGIPFIPMARKPQGKSFRKALVLLELSANQAVVVGDQMMTDVLGGRRMGLHTILVTPIARGEEGWGTRINRRIEKFALARLSRKGLWPLKGGKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ07</accession>
    <name>A0A398CZ07_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05077">
        <property type="protein sequence ID" value="RIE05077"/>
        <property type="gene ID" value="D3H35_02800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="571" mass="62605" checksum="094C7AF81EB813F7" modified="2018-12-05" version="1">MIAAKKSQQYAGSRLSSNQIRCEGDNRSMNKLKKIAMPALAFSLLFVMAACSSNDNSSSPSAPASGSPTASSSASGSPDTGKKYTISMLDFTYGKIPPSDGQGVKLLNEKFNIDYKPTIVPYEGYQEKMSTTIAGGDMPDVLGIEEYLAGGTLHTWAEQGAFLPLNDYIKKYPTLAAVPEEVWAIVTSKDGKIWGIPRYYPNNPTQNWVIRQDWLDNLGLQMPTSYEELAKVALAFTNDDPDKNGKKDTYGLVMGPGASPSYAMGAYWDRDAWYHKNADGNLIPGYISDAYKENVIMFTDLYKKGAITKGFGANAGFEVGQADFYNGKAGMFMGGIRGMDENLANSLLSVAPNAKLSSIPPFVAPDGTQGLTAQRGYYRITVLNAKLAGDEDKINRILSLVDYGRTFIPVSERTPDNETFDFRSGKANTGYTYENSVTTFTQPDQGLMPSSYLPDANMWAPSVLDNKYSELMNNPLLKPYVQQLEKEYSDYEEYVDPGYIGYSPILNTGKGTDAINKVIDAQVKMIMGELPLSNWDKVIADYMKNGGGDIIKEMNESLKGKTLTGFKKMGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZS9</accession>
    <name>A0A398CZS9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04424">
        <property type="protein sequence ID" value="RIE04424"/>
        <property type="gene ID" value="D3H35_07520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="60" mass="6581" checksum="58C1CE7B2075985A" modified="2018-12-05" version="1">MKRKTNPLLYVIFGVLLAAFGVIDLLYVNRLIGTALVIAGIWLGINGLRLRSQAKKNAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZT1</accession>
    <name>A0A398CZT1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_04300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04711">
        <property type="protein sequence ID" value="RIE04711"/>
        <property type="gene ID" value="D3H35_04300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="39"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="359"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="392"/>
            <end position="399"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="600" mass="66923" checksum="C431BBB828DDD500" modified="2018-12-05" version="1">MSRKFVYQDDELIEKPFNWKQVGRLFSFFRPYRAGVAKVVFVMTVFGMLSRLAIPFLMSKAIDGAISPGDGQKGDFTLLAALVAAMLVLYGLRWWAQHYTIAHTNLIGQKVVFDLRTALFKHIQSLSFRFFDKRPAGSVLVRVTNDVNSLQDMFSNGVVNTVIDILQLIGISIILLVLEPKLGLAVMITVPLMFIVSTSLRKRIRFAWQVVRIKQSRINSHLNESIQGMRVTQSFVQEKENKQFFESMNHGNIRSWNTASALNQLFGPVIEVTSAVGTLILLAYGTYLIQSDAMTVGVLVAFITYVGSFWEPINRLGMMYSQLLIAMSSSERIFEYLDEKSAVPEKPDAIAMPPIRGAVRFEGVTFGYETDRPALKGIDLDIQPGMSVALVGHTGSGKSTIVNLLCRFYDTVEGKVLLDGIDVRDVTIESLRSQVGIVLQDTFIFSGTIRDNIRYGRPSASDAEVEAAARSVLAHDFITHLPDGYDTQVEERGSALSVGQRQLISFARALLANPRVLILDEATASIDTETEMRIQEALGTLLEGRTSFIVAHRLSTIRHADRIVVLDHGVIVEQGNHEELMQRPGHYRNLVDAQYRVLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D212</accession>
    <name>A0A398D212_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_03125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05144">
        <property type="protein sequence ID" value="RIE05144"/>
        <property type="gene ID" value="D3H35_03125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="29" mass="3280" checksum="23ECE9045F1672E4" modified="2018-12-05" version="1">MAYDSFGNLIKVNDAEGQSYSYTYDGWAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CAZ2</accession>
    <name>A0A398CAZ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000059">
        <property type="protein sequence ID" value="RIE00306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00306">
        <property type="protein sequence ID" value="RIE00306"/>
        <property type="gene ID" value="D3H35_29240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="103" mass="11581" checksum="0C32B27661896A46" modified="2018-12-05" version="1">MDKFTHLGKEVLTIVNSAVVIILLVVLINKDLVSVGDYIAVTMAVAIIINFSNLIEDYIRMLENLNYSVKAKQMKEQIAEKSIIKSAHGKSLLDFMNKLIYPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CB06</accession>
    <name>A0A398CB06_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000057">
        <property type="protein sequence ID" value="RIE00326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00326">
        <property type="protein sequence ID" value="RIE00326"/>
        <property type="gene ID" value="D3H35_29075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="353" mass="39511" checksum="2D33AF3BAF29C57F" modified="2018-12-05" version="1">MGIMRRLYRGFIDLKIQDKIFLCFVVVIIASVLGIGISSYYKSSAIFGKKTSRYNVETVQQISTSVDYTLERIDDLSGILAFDQTIQRVFNTDMGAMSERETIAAVNEIESIMITHYNSQIMRSIEIYGNNGLVVKVPSSFNEQGNGPTPKQFVEMASVYRGKTKWLNDAQEHGLLYAVREINELQTAVKPLGTVIISLKSSMVADLLKNVDFDQSGAVLLMDENGSPVIASEPFGQPQAVEEIRQIAAFSSGSSIQTIGGERYFVSFRTSEYTGWKTVGIISLDKLYEDSRMIREWMIVVTLVILLFAFVLARIFAQTITRPIKRMLIPMKKSADGRFGRSFPSAARMKSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBM8</accession>
    <name>A0A398CBM8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00183">
        <property type="protein sequence ID" value="RIE00183"/>
        <property type="gene ID" value="D3H35_29525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="62" mass="7126" checksum="A0B6C7BFF48C9CB6" modified="2018-12-05" version="1">MNLLTGFKTLNSLKIEDIQLDHFEIEVGEMNYGLEINGILGFDFMRIAGIIIDTEMLEIHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDS3</accession>
    <name>A0A398CDS3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DeoR/GlpR transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000046">
        <property type="protein sequence ID" value="RIE00863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00863">
        <property type="protein sequence ID" value="RIE00863"/>
        <property type="gene ID" value="D3H35_26050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DeoRC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="91" mass="10027" checksum="B14BDABEA76ABAD7" modified="2018-12-05" version="1">MSADAVDIHFGVSNTTFVEQNIKRLMLEAAKASALVCDHTKFGNTALAKVCRLDELEHIITDEGISPSLREEMERLGLPVIVVQTWKASSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE64</accession>
    <name>A0A398CE64_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_24230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01466">
        <property type="protein sequence ID" value="RIE01466"/>
        <property type="gene ID" value="D3H35_24230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="60" mass="6926" checksum="C7A610E7C21B8944" modified="2018-12-05" version="1">MRLLISYVGESIISGEMDAAGSAEDWERPHSVQSEGPFMPSVHTLRMHHFIRQRKLRISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEI8</accession>
    <name>A0A398CEI8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">recR</name>
        <name evidence="9" type="ORF">D3H35_21610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RecR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01040">
        <property type="protein sequence ID" value="RIE01040"/>
        <property type="gene ID" value="D3H35_21610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015967">
        <property type="entry name" value="Rcmb_RecR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01300">
        <property type="entry name" value="RECR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="80"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="7">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="199" mass="22036" checksum="CB4A4CBB80E12516" modified="2018-12-05" version="1">MFYPEPIAKLIDAFSRLPGIGPKTAARLAFFVLRMKEEEVIDFAKALVSVKRNLTYCSVCCNITDADPCRICSDKTRDASVICVVQEPKDLVAMERTKEFNGYYHVLHGAISPMEGVGPDDIRVAELVRRLSDERVQELILATNPNIEGEATAMYLSRLVKPFGIRVTRIASGLPVGGDLEYADEVTLSKALEGRRELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CES6</accession>
    <name>A0A398CES6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_28545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00372">
        <property type="protein sequence ID" value="RIE00372"/>
        <property type="gene ID" value="D3H35_28545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="37"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="471" mass="50982" checksum="6BDEAA57AE3F7582" modified="2018-12-05" version="1">MLENGIKQELAAVVGSSFLKDDKQTLVAHSYDGTPMLQALPDAVIYPGSTQEVAAIMKILNRHRIPLVSRGSGTNLCGGTVPVLGGVVMVMHRMNAILEVDMQNLTATVQPGIITKKFIEHVESLGLFYPPDPSSMSISTIGGNIAECSGGLRGLKYGTTKDYVLGLECVLASGEIIRTGGKLVKDVAGYDLTKLLIGSEGTLAIVTEATLKLVPPPKYKKTMLAMFSDLYDAARTVSKIIENRIIPATLEFMDNPTIRVVDDYAKLGLPLDMAAILLIEQDGDTETVERDIERISGICRDENATQISIAHTQEEALKLLTARRSAFTALARLRPTTILEDATVPRSKIADMVLEINRIAQKHDVTICTFGHAGDGNLHPTATTDARDQEEIHRVEAAFEEIFEAAIALGGTITGEHGVGLVKAPFLEWKVGSAGVEIMKNIKLAFDPLSLLNPGKMFAKQSRRRVVLERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEU3</accession>
    <name>A0A398CEU3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YhfZ_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00392">
        <property type="protein sequence ID" value="RIE00392"/>
        <property type="gene ID" value="D3H35_28690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032791">
        <property type="entry name" value="YhfZ_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14503">
        <property type="entry name" value="YhfZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YhfZ_C" evidence="1">
        <location>
            <begin position="9"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="239" mass="27286" checksum="C6A9C3B8B759ED4C" modified="2018-12-05" version="1">MGTYLLSKDDAKLWQIADFGIIVGLLPLPNAIEYEGLATGFTESLLRSGVKFSLNYKHGAVERVKNLIDNRCDFIVLSNSAAETVLEQYTDLYALQHLSALTYYSGVYLIKRKDLDIDKTKWRIGIDRTSYDHITFSDNEFPENSKVNVHYVNIPYFIANGTIDAAIILNRTHIAIDLMEYLTIESLETTDYLRNRSSATIVTKKDLGMIGILFKEMVDLELIENVQRDVMERRVVPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEZ8</accession>
    <name>A0A398CEZ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01303">
        <property type="protein sequence ID" value="RIE01303"/>
        <property type="gene ID" value="D3H35_23250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="149" mass="16604" checksum="BEB1CB4A32180059" modified="2018-12-05" version="1">MGIRGEGMVTAIDVRDAVIGALGEAFPGLPIHTETVDEGVVKPCFFVKDFPVAQSRIMGRRYARAHSFDIQYFPLSAIEPIEEAHDAAERLTEALEYIPLEVGQVRGTGMRYEFVDSVLHFFVNVNLYMFKPIMPVPLMGSVEVEEGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG24</accession>
    <name>A0A398CG24_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_05350</name>
        <name evidence="2" type="ORF">D3H35_22895</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000024">
        <property type="protein sequence ID" value="RIE04594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01673">
        <property type="protein sequence ID" value="RIE01673"/>
        <property type="gene ID" value="D3H35_22895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04594">
        <property type="protein sequence ID" value="RIE04594"/>
        <property type="gene ID" value="D3H35_05350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="50"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="249" mass="28271" checksum="37B34B96066C992A" modified="2018-12-05" version="1">MNEKEYMDFYDRVGPLNGWDFSKLKCRVEGTPANLYEEVKKCCKQSDLLLDIGTGGGEAILALHEAALLLVGIDRSSGMIQKARDNLRHSGLANVRFIQMDAERLDFPEQFFDVVSCRHSEFSAHQAAKVLSQGGIFFSQQVSEGDKINLKQAFGRGQSYGDSDGNIMKKYIQDITEAGFTEIQSFEYDSEEYYQTPEDLIFLLKHTPIIPNYGQDRDDFEILHAFIAENQTAKGIRTNSKRFILKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGF3</accession>
    <name>A0A398CGF3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_13545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01813">
        <property type="protein sequence ID" value="RIE01813"/>
        <property type="gene ID" value="D3H35_13545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="31"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="133"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="526" mass="60352" checksum="99522123E7366F31" modified="2018-12-05" version="1">MRGTDRTNEAIVSLVQEAQAGNDIAFGELIGLYRAKAYRWARDVVKDPYLAEDIVQDAFLRAYLRKESLLGADHFMAWLYRIVRNEALMKARRGGYYRKERPVDAGHESFLQAIGDPESEPDREAARIESENMLRRLLDGLNTRERAVMEAHLFSRLSAGEIAVRLLLTPANVYQLLSRSRQKLQKARYGLLLQDYLDAVTRAGVAGKRHIPLPFQYFGEVWDTAILGALLIMKNTHGNEYTLPRLMGMTGQAFRLTLHRDRLDASSPFAFHWGRAYSEGFANIGYQAEYRWSADRPCTPETFLETVAWVRRAIDEGSPIIGWNLRNPLFGLITGYHDQAQKFEIAGMWEHRQAAYEDFVRKELFVMRIAPGRPREEEEMFFSAIKRMGDHAFGTEEAIEGTVQGLEAYDVWIRLLREGACENFGMCFAVAYTGDARRNAVLFLQECLDSNMPLYKRPGIRLALETALRHFREVHSALWKLRALYPYPRGVQAPSGSESERQAILLLEKARLEEEEGWKALRFIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGI4</accession>
    <name>A0A398CGI4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_29565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00189">
        <property type="protein sequence ID" value="RIE00189"/>
        <property type="gene ID" value="D3H35_29565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="74"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="280" mass="31491" checksum="6372B79599CDF6BD" modified="2018-12-05" version="1">MKAKKRNELIVKIGIHATLILFAIIVLIPFYWLIVNSLKSTGDFYSLSKSLFPTRPTLDSYRELFNETLYMMWFKNSFIVSVLAVALGLLICTASGFAFASYNFKFKNIIFWTVLGTVAIPEIVTIIPVFNIMVNVGLIDKYASLILPYAVSMFGIFLIKQFIETSLPNEVLESARIDGLNEYGIYFRIVLPLIKPGIGVLAIFLWLNSWSSYFWPLIMIRSTEMMTLPLGLATLYANPYDLKYGVLMAGNLIATVPIIFIFLAAQKQFIEGLTVGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGU4</accession>
    <name>A0A398CGU4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02426">
        <property type="protein sequence ID" value="RIE02426"/>
        <property type="gene ID" value="D3H35_17125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="162" mass="18882" checksum="460E5EB73C190706" modified="2018-12-05" version="1">MHERGECLLLQRYIRSDQDQLEDFMKTMYVSRGYVFDPEGPHSDIRSIELLYFETGGGFWLLKEEQSVIGTIGLKGIDSENRIGEIKRFFVLPEYQDKGYGKSMISQIIEFARQAGLIKLRLDTEKQSYKAMSVFRSFGFYEIPKYNDNDIAEIFMELSIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGU6</accession>
    <name>A0A398CGU6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_24220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01690">
        <property type="protein sequence ID" value="RIE01690"/>
        <property type="gene ID" value="D3H35_24220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="149" mass="17056" checksum="B2EDE28055731DE6" modified="2018-12-05" version="1">MNIAFFLLPKQDVVCLVHQATLRQTLERMEHHRYTAVPVLDEKGHYMSTVTEGDLLWYMKNHPELSFDQLHKVTLSEVPMRMKNLSVRIDANMEDLISLAKTQNFVPVVDDMNKFIGIVRRSEIIDYCEKLLIPGNGAGRGETKAAKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH15</accession>
    <name>A0A398CH15_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00198">
        <property type="protein sequence ID" value="RIE00198"/>
        <property type="gene ID" value="D3H35_29615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="391" mass="45359" checksum="B8C0F3D4FAFAE6FA" modified="2018-12-05" version="1">MRYSSIIYTNSRGWITMEFEKYIIQKNIEHAIKSEAVTKLSDILRLLPKTRLYEIATNRDLLGRSKMSKQELADALFELIPDVYELETTLIISDAEEWNLFNKLLKAPYVQEETLTPRMYLFLMNRGLLFSFYYEDKLIYSIPEEIKDSYRQLSQQSFHEARDRCQLINQYISASANLYGICTLDKTIEIFNAQNEKQVDENELISFLNLASGRGQEWYLNQGYIISNYFDSEDQDEELKALLERAKHKPYYIPPQPEFLKYADSGYFEETPQLVSLRAFILKHLCKDKEFVENLVDDIQVACSMEEPLSVIMGEFERRDIIFDNNAQVQAIMPLIIDVYNHTRIWSNRGHTPAELGGGAGQTARPISNKVGRNDPCPCGSGKKYKKCCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH43</accession>
    <name>A0A398CH43_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioredoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_13365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01785">
        <property type="protein sequence ID" value="RIE01785"/>
        <property type="gene ID" value="D3H35_13365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="199" mass="22589" checksum="8E4EF817F2C4F8CB" modified="2018-12-05" version="1">MSETLNLKHKIGTGITPQAFIDGMTRNRDELLGWYNRFAWKDENEAFFRVAGESGDLHGFILCTDWCPDVIWNVPVLLHVMEHSRISTEVLLMEQHLETMDLFLTDGGRAQPIAVFVSSNGDVQGQWGARPQYIQAVMNDFRKRNPDREAPDYQEKVTDVRNEIALMYNSGTGYQDVIVQELRAVFAAMPGIGVREANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHE0</accession>
    <name>A0A398CHE0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_15635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02173">
        <property type="protein sequence ID" value="RIE02173"/>
        <property type="gene ID" value="D3H35_15635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="705" mass="77267" checksum="516F338AEA1E8A2E" modified="2018-12-05" version="1">MITATSMPSSADRKTFDTQCPFCSVQCKMEVTEERAASGARPVYTVVPKLNAASEGRLCIKGMNAYQHALTGDRILQPLVKKDGHFVPVSWEEAYLLIKRKFDALSDNGGPDTLGLYGGGSLTNETAYLLGKFARVALQTRYIDYNGRFCMSAAASAGNKTFGADRGLTNPMSDIPLAKCIILAGTNIAECQPTLMPYFTRAKENGTYFIVIDPRETGTTAIADLHLKVKPGMDAALAGGIQKVLLDEGLIDEKFVNERTTGFDDVRSSLESLDLGEIADITGVSAEQIRQAALAFGKAATAMVFTARGVEQQTDGYMAVRSFLNMALMTGNMGKPGCGYGAVTGQGNGQGGREHGQKADQLPGYRLIENPEDRAYIAGVWGIEPAELPGKGVSAYEMMQKIHAREIRSLFVMGSNPIVSNPNANFVEEGLKKLDFLVVADMFMSETARLADLILPVSAYIENEGTMTNLEGRVLLRPANRPVPGEAKHDWRILCELAELLGKGSFFRYESSEDIFEELRIASRGGIADYYGITYERLRKEEGIYWPCPSVDHPGSPRMFEAKFAHANGKAEMVPVPVHFPDERTDDSYPLNLTTGRVLTHYLTGVQTRRSHTLAARDVESYLEIHPVTARKHGVREGTLIKVASRRGEIVVRCRLSGAIREDTVFVPMHWGDTQNVNKLTNPALDPTCRMPGFKVCAVRVESLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHK0</accession>
    <name>A0A398CHK0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-layer homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02696">
        <property type="protein sequence ID" value="RIE02696"/>
        <property type="gene ID" value="D3H35_18750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="100"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="160"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="227"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="287" mass="30347" checksum="BAD0BC312759FAEF" modified="2018-12-05" version="1">MKTAWQASGITLLGALAVTFELTITSGGTSRTIDDFGDSFVVRSFPVGNGPIDSERTSVFYGKEGEGEPGFAPARFFKDPVGVYHAIVSRTGNSTYAAGYKKAVFLDLGSHWAERVVDKLAAKGLLSGKTESAFAPDERITRAEFASLLVKGLGLQDEQGASAFRDVKEPSWYAKDVSIATGKGLLTGDPGGSFRPNAPLTRQELAVIIANALRYAKPQEKLAEASLASFTDAYRVPGWAEGAMRTVVAAGILSGDGSGRLNPGGYATRAQAAVAVERLLQKLGFMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHP2</accession>
    <name>A0A398CHP2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02303">
        <property type="protein sequence ID" value="RIE02303"/>
        <property type="gene ID" value="D3H35_16400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017255">
        <property type="entry name" value="AcTrfase_GNAT_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037663">
        <property type="entry name" value="Acetyltransf_GNAT_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="140" mass="15563" checksum="1D3E09CA8E3780E5" modified="2018-12-05" version="1">MQIRSFQLSDYRSVAELLENVLSEECCEETMGAFARQLSWDSDLVLVAETESGIVGVLIGTIDQQKGYMYRIAIDPDCRGRGIGRALVSSINNRFRQRNVLKVLIAGDKHNELLKPFYEALGISLKDFANLARPLAIVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI52</accession>
    <name>A0A398CI52_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA repair protein RadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">radC</name>
        <name evidence="8" type="ORF">D3H35_24480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0758 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01692">
        <property type="protein sequence ID" value="RIE01692"/>
        <property type="gene ID" value="D3H35_24480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020891">
        <property type="entry name" value="UPF0758_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00608">
        <property type="entry name" value="radc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01302">
        <property type="entry name" value="UPF0758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="14"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="136" mass="15159" checksum="3C12D135ED6DE056" modified="2018-12-05" version="1">MVREKTSLLYPQRKISSPQDAAEIFRQFIGEFDRESFCILCLNTKNEPTALHQVSFGTLNASLVHPRETFKLAILANSASIIACHNHPSGEPTPSQEDIQLTERLRDTGTLIGIELLDHIVLGNGNFVSLKERGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI57</accession>
    <name>A0A398CI57_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_26105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000047">
        <property type="protein sequence ID" value="RIE00849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00849">
        <property type="protein sequence ID" value="RIE00849"/>
        <property type="gene ID" value="D3H35_26105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="68"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="275" mass="30522" checksum="2C03F4E485005DBD" modified="2018-12-05" version="1">MKKTRNLLFELGVILLALIVSIPLYLVIINAFKPHPEIVKHPLAFPTFEVGFDNMINAFEKMDLIKSYGTTFSIGALAMFIAVGLGALAAYAVSRIKHPFFSTMYWVYTACILIPIQSALIPVVLLMRDLHLQNSILGMSLMYGAMLSPFCIFMYSGFMRAIPYELEESAYLDGCSPARTFFQIILPLILPVTASLIIVQFISVWNDLQLPLVLLNSADHPTVSISLYKFFAGRSMSDLSLLFGGIMLTLLPIIVLFVSFQRFFVKGLSAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI67</accession>
    <name>A0A398CI67_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_20400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02966">
        <property type="protein sequence ID" value="RIE02966"/>
        <property type="gene ID" value="D3H35_20400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="286"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="319"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="537" mass="59000" checksum="05EDF4E1DBDBAE50" modified="2018-12-05" version="1">MSTKEGGTILQVSGLQVAYRQNGQSVTILDNLAFELKKGEILALIGESGSGKSTIAKAVTGLLPPSAQIGGGALKIGSALIADMSDKSVQWERIRGRGIAMLFQDAQQALNPVMKIKEHFRESLLFHRLASSEAEIVSISVNLLTRLNFAEGHRILDCYPFQLSGGMCQRICLALALCLKPAVLIADEPTSALDTVSQKEVLDLLKRMQEELGLTVLLITHDIAVANAVSDRVIVLNKGVIAEEGDTRAVFSKPQAAYTRQLLSSRSSIAKRPRNREQPHSGKPLLEIVRLEKTFNRKKRVLHDVNLTLNSKEIVGILGQSGCGKSTLAKCIAGLETPNGGRVVYRGTDISRLQGRAKRDICKHIQLVFQDARASLNPGRTALQLVQEPLRYLRIGNEKEREAMARFYLQEVGIVGDMQTRRPPQLSTGQCQRIAIARALVLSPEILICDEAVSALDMSVQAQILALLQRLHKQFGFSILMISHDVRVLRSFCHQIAVMNDGSFCEVKRASELIHESDQPHTQLLLKCAGDLEQGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI97</accession>
    <name>A0A398CI97_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_20560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02996">
        <property type="protein sequence ID" value="RIE02996"/>
        <property type="gene ID" value="D3H35_20560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="643"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="750" mass="85089" checksum="61F2F04734189D16" modified="2018-12-05" version="1">MIRLGIRNTFFIKVFMCFLALTVLFSLFYSVALSFFKQRIKNEILHTNRTVLRNASERFNSQLNRIKTLLIETNDNADLIGFNQQLLSKPEADVDYLRAKRVIRSLQSEIYKPQTYLETIIVQFKSVSFSFSHKGSSSADLMFGQLYASEAYSHGFGNDEPSGLTSFKLLPVGRFFINGVSKPILPITFEQRGRNYRLTALLDIEEAYDALVGSLTSPGELVILDKDGNELYRRGELPSVSLPALDTDREYLYRAGNYYFYERDAAGTSYVYVLPYKKVIAEMRGLTDRWLLIWAAVLTTGVVAAYFFSRRIQIPVKNLLSAVLNRKPATASSSIQEFDLIRSKINDLLDEREKIADTVEKQSTALTSYSYINRLKDINAESSEWQSLLSAEKSYVVVLYSFRSRRSHRSGSSSLDHGQEEGRRAMLERMDRVVTERFPDSSTFQIERDQFVSVIAEAEREPIIALMSEWKNDPDLEPPDGVLTIAIGTPFGHPSKFSGAYKQVQKMVGQAPLSEKTEIVTNLAGVSPFTLNPKQDHSLNAFLQSGNEDGAYRQLEQLLEQMSRDKASCSHFAELSDIVLSKVSVAVEPLQRNSGASEKLQAFPALLKECFTQAEYKQTFRELVSVVCELIREDKEEQDPVAALVMDILNKRFAQDLSLSYLADLLNMSSAYLSVYIKEKTGSNFSEHLNGIRVRKAQELLVTTEMNINDISLQVGYTNFTSFNRMFKKQTGMTPGEFRRRQIMQIHKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CII0</accession>
    <name>A0A398CII0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urease accessory protein UreG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">ureG</name>
        <name evidence="7" type="ORF">D3H35_21200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03096">
        <property type="protein sequence ID" value="RIE03096"/>
        <property type="gene ID" value="D3H35_21200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="PTHR31715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 4" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="6">
        <location>
            <begin position="26"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="224" mass="24498" checksum="05A8100CB7931886" modified="2018-12-05" version="1">MCQGQGHHHHHEWETPAAQGGRPMRIGIGGPVGSGKTKLVEQLAFQLKEKLNLAVITNDIYTKEDARILSDTGCLDDERIIGVETGGCPHTAIREDASMNFEAVEELEHRFPDLDLILIESGGDNLAAAFSPELVDRFIYIIDVAQGEKIPRKGGPGIMRSDLLIINKIDLAPYVGASLQVMEDDSRKMRGEKPFVFSNLMGGDGLADIAGWVERETGRHVSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIS9</accession>
    <name>A0A398CIS9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1361 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00768">
        <property type="protein sequence ID" value="RIE00768"/>
        <property type="gene ID" value="D3H35_26615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009793">
        <property type="entry name" value="DUF1361"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07099">
        <property type="entry name" value="DUF1361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="234" mass="26416" checksum="12FC57D6DC4A7317" modified="2018-12-05" version="1">MTDSRSAHKYNPVVTPMVTVLLALTAVCFCLVVLRAFRVERDEYGFLLWNLFLAWLPLVVSIAAILYSRLAPKRLLTPGLVILGIAWLLLFPNAPYLTTDFIHLLFGGRLFTSFNSIGLLFWFDLIVYFLFAWCGLLLGYLSMRHFQAIVQRYSSLAVGWAFVIAASFLGGFGVYLGRVVRLNSWDAVFSPFRLIEGVIEGLTPDAAVFTFMFGFFIFGIYVSLYALQRDRSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIU7</accession>
    <name>A0A398CIU7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_20005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03216">
        <property type="protein sequence ID" value="RIE03216"/>
        <property type="gene ID" value="D3H35_20005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="135"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="377" mass="42177" checksum="054F9AE1596531C0" modified="2018-12-05" version="1">MVGYKFMGKAHSHAYKDVGMFFETNADVVMKAICGRDEQGVKAAADKFGWESYETDWRKLVEREDIDIVDINAPSDAHKEITLAAIAAGKHVFCEKPLALNLADGREMLAAAEKAGVKHAICFNYRFLPAVQLAKQIIDEGRLGEIHHYRATYLQDWLVDPNFPLAWRLKKEVAGSGAHGDLNAHSIDLARFLIGEFDRVIGHNRTFVKQRPIPESSEGLSGNGSAEYGEVTVDDATGFLADFKNGAMGMFIASRFATGRKNHNTFEIHGSKGSIRWDLERLNELEVYFREDEPNLAGFRTINATDASHKYAGNWWPVGHAIGYEHGFVHIVYEFVKHIMEGTPFTPTFLDGVRCQEVLEAVDLSIERGAWVSIEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ32</accession>
    <name>A0A398CJ32_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Adenylosuccinate lyase</fullName>
            <shortName evidence="11">ASL</shortName>
            <ecNumber evidence="4 11">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D3H35_16645</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 11"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02345">
        <property type="protein sequence ID" value="RIE02345"/>
        <property type="gene ID" value="D3H35_16645"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="13">
        <location>
            <begin position="349"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE02345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="431" mass="49670" checksum="5840E8DF77D688C5" modified="2018-12-05" version="1">MIDRYSRPEMRAIWTEQNKFQAWLEVELCACEAWAELGHIPKEDTVELRKNAKFDIDRIYEIELETRHDVIAFTRAVSESLGAERKWVHYGLTSTDVVDTALGYLLKQANVILKRDIENFIAILREQAIRYKDTPMMGRTHGVHAEPTTFGLKLALWHEEMKRNLERFERAADGVQFGKMSGAVGTYANIDPLVEQFTCQKLGITPAPISTQTLQRDRHAEYMATLALIATSIDKFATEIRGLQKSEFREVEEPFAKGQKGSSAMPHKRNPIGCENMSGLSRVIRGHMLTAYENVPLWHERDISHSSAERIILPDATMLLNYMLNRFGNIVKNLTVFPENMLRNMRSTYNVPFSGRVLTKLIDKGFSREQAYDTVQPRAMQAWEERRDFREIVESTKEITELLSAEEISDCFNPTWHLKHVDTIFDRLGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJE4</accession>
    <name>A0A398CJE4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02252">
        <property type="protein sequence ID" value="RIE02252"/>
        <property type="gene ID" value="D3H35_16085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025699">
        <property type="entry name" value="ABC2_memb-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13346">
        <property type="entry name" value="ABC2_membrane_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="241" mass="27363" checksum="385E9EB14FF58B84" modified="2018-12-05" version="1">MSVWQAVKHLGRFQLKSDWLGFVLTLLFVLYSGGLISVTLNDVLTDPETPKNANGLIDWMYLCLFPAFGLLINKNSISVWRNNTYHKRLSHWRTMPIPAEAIVLSRWLQAAVMVPLNGLVYLFLQYAISSGLRAEATAIQWLENAIVWIGYGLVVNAFFIFLELGYDGKKFTVIYTSFFVVSAAAVAFLTWQDIHVVDTVLAQIQTGRVWLPILSVLLAAVAFREGFRLTLRRIKSRPFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJT5</accession>
    <name>A0A398CJT5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_11100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03576">
        <property type="protein sequence ID" value="RIE03576"/>
        <property type="gene ID" value="D3H35_11100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01541">
        <property type="entry name" value="PBP1_AraR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033532">
        <property type="entry name" value="AraR_ligand_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="364" mass="40575" checksum="8059D158C79048BA" modified="2018-12-05" version="1">MSSRSPKYMQLKEQILSWIAGGRFRPGDKLPSENELAEQFSLSRQTVRQSIGELVQDGWLAREQGKGTFVTRLSADRRVTGGTRTVGLITTYISDYIFPSIVRGVEAALKDRGYRLLLSSTDNRKDRERESIEMMLGQAVSGLIVEPTKSAEGNPNFDSYMALENHGIPLVMINERYSDIECPCVKMDDEGAGHTAANHLLALGHRRIAGFFKTDDLQGVNRMKGFVRAHREQRLTVEAELLVRYTTEDKENRPAEALKQMLNSPERPTAIVCYNDQLAVALMDVIRETGLRVPEDLSMVGCDDSFLATATEIKLTTIEHPQTAMGEQAANLLMSILEKEGRPGNQGAVYPPKLIIRQSTTSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK32</accession>
    <name>A0A398CK32_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02502">
        <property type="protein sequence ID" value="RIE02502"/>
        <property type="gene ID" value="D3H35_17580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="107" mass="12015" checksum="D49FED7A9F8B3B53" modified="2018-12-05" version="1">MGMSKAKKSRLKTQREGKLNPEIGRLEWTRKPITQVKPNTKAEQRRSQCRHKGSRDGAYFFGTVKITAVESATNKLPPNGKEGAPHPSLGGTLFVYLVFNTMLKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK72</accession>
    <name>A0A398CK72_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18770</name>
        <name evidence="3" type="ORF">D3H35_18865</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02700">
        <property type="protein sequence ID" value="RIE02700"/>
        <property type="gene ID" value="D3H35_18770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02713">
        <property type="protein sequence ID" value="RIE02713"/>
        <property type="gene ID" value="D3H35_18865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="35"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="281" mass="30531" checksum="907FE19AFF8A98C7" modified="2018-12-05" version="1">MPKVEAYIESVANPRVKGWVKLTERKYREREGRFLLEGVHLVAEALQAGWPLEHVVYDAGADLPEELLRYKESDEEYDSLENVPSWIPVSPEIISKCSATDTPQPVFAVARKRIVDTDRLFSEERSLVAVLDGVQDPGNVGTIVRGAAACGATAVVLGRGTADLYNSKTLRATMGALFHVSVVEGDLKELLPEAKSRGIAVAGTSLQAARSCYEYDFSGPTWLVFGNEGSGLSTAVSDLVDSNLIIPMTGRAESLNVAMAATVLLFEAQRQRLFNADNNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKJ3</accession>
    <name>A0A398CKJ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FxsA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02885">
        <property type="protein sequence ID" value="RIE02885"/>
        <property type="gene ID" value="D3H35_19910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007313">
        <property type="entry name" value="FxsA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35335">
        <property type="entry name" value="PTHR35335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04186">
        <property type="entry name" value="FxsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="132" mass="14707" checksum="AE60AA5B74EC4C8C" modified="2018-12-05" version="1">MVKRLAVIFIIFLAIELWGIIEMVQRIGGITTFGLLLLTGILGGWFARAEGSKIWADARRQLQSGQMPGFALLDGLCVLAGGLLLLLPGFLSDIVGITLLLPFTRPIYRLFMYRWLEKKVRSGSISIRRGPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKK1</accession>
    <name>A0A398CKK1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02672">
        <property type="protein sequence ID" value="RIE02672"/>
        <property type="gene ID" value="D3H35_18605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="100" mass="11901" checksum="3D3C324BA89C8B8B" modified="2018-12-05" version="1">MKGELVGMDKQIQEWIFQYRLAERAIQGIDSEKQPERHALLKQRMEEAELQLTERGTETIRFMGKQLLRYAAALHETFEHRDSPEEIRRIVEQAFSREEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKL0</accession>
    <name>A0A398CKL0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_13110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01739">
        <property type="protein sequence ID" value="RIE01739"/>
        <property type="gene ID" value="D3H35_13110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="4">
        <location>
            <begin position="12"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="331" mass="36459" checksum="3F32724D23B64655" modified="2018-12-05" version="1">MKALVIEKPFQASIQEVEYPIPGMNEVTIKVERTGICGTDIHIYEGTYMSSYPLIPGHEFSGVIHEIGANVTGYSVGDRVSADPNIFCGHCEYCQTHRSNQCLNFAATGVTRNGSMAEYVRVPANTLIRMPDPMTFQQGAFIEPMACVVYAMNRLQVQAGNRVILFGAGAMGQQLVQAISRSGASELVVVDISPSKLRIAEQYGATLTVLSDELDARLCGQTFDIVVEATGIPSVIQRAFSYMGPAAKYLQFGVADSDVTVSLNPFKLFNNDWTILGSMAVHYTTIPAMRWINEGRIQVDHLVSQTLSLEETLDFFEKPKDRDLLKTQIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKX7</accession>
    <name>A0A398CKX7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02832">
        <property type="protein sequence ID" value="RIE02832"/>
        <property type="gene ID" value="D3H35_19565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="103" mass="11347" checksum="DF5FCA3A76A43414" modified="2018-12-05" version="1">MSQANIPNITPQISVNRTDVINLLLASIALEELGLSHIINAEGEKIQHVLGTLPGQSPTHPTLSDLLTINESVRNTIREIAKKEFLLQTKLENVIELIKHPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL54</accession>
    <name>A0A398CL54_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_08965</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04066">
        <property type="protein sequence ID" value="RIE04066"/>
        <property type="gene ID" value="D3H35_08965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="9">
        <location>
            <begin position="14"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="425" mass="44981" checksum="28F24737DAE85058" modified="2018-12-05" version="1">MEIAELSRGMDTIWVVLTAAMILLMEGGFALLEAGFVRQKNAVSIIMKVFVDISFGALVFYFMGFAIMYGKDAGGLIGTTGFWMDGDLSHLQLNISTDTYWLFQCAFVIAVISIVSGAVAERIHFRAYIVYTILMTGLIYPISGHWIWSPSGWLAKLGMIDFAGSAAIHALGGFAALAAALFLGPRIGRFGADGRTNIVPPSNLPLASVGAFILWFGWFGFNSGSTLSATNENIGHIAVTTMLASAAGCAACILFTLFRYQKADPPMAINGALAGLVGITAGCAFVSDGAAILIGAVSGIVMILASERLEKHRVDDPVGAFAVHGISGSIGTLAVGLFALPGSAAHTGLFYGGGWYLLGVQALGLAVVAVWGFALTWGALKLIQWFKPVRVSRDDELIGLDVGIHGVPAYNQEHDFLDVDKLRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLH4</accession>
    <name>A0A398CLH4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe/B12 periplasmic-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00697">
        <property type="protein sequence ID" value="RIE00697"/>
        <property type="gene ID" value="D3H35_26215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="215" mass="24226" checksum="9E6943508640D619" modified="2018-12-05" version="1">MGGIRKSEAGLNHRRFLSFFLSDRFQGIAPVSSLLADRSWVNNYRKMAEILGSSEEAEQAVNRFAMRVAAARSLLAARMGGKSIVVLQVTNHNIRIQGATDHPLSELLFGELGLQPGRTEQSNAKRLELQPEWLPQIDTDYALVFQNHIRAGSETIYDRMCGTHAWRSMRAVQNGNVLLIPNWFKMSWSPIGREEIIDELLMMTDTLPEAAKESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLI7</accession>
    <name>A0A398CLI7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_13185</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03120">
        <property type="protein sequence ID" value="RIE03120"/>
        <property type="gene ID" value="D3H35_13185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="444"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="715"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="942"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE03120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1052" mass="116768" checksum="A1B363FA0BB996B3" modified="2018-12-05" version="1">MLTKNKTSLQNIAVILLFLSALLGLRWAWSEVFSTAEHPGAVAGVLDMRGWDLDESPTVALNGEWKFYPGKLLTHRDTPLAADQARNIQVPGDWSGAQAEDSGSSYGYGTYQLRILIEPPDQPIAFWLQGIQASSSVEINGLAAAQTGEPAAAANEYKPKNISYTASHSVEGATEIELLIRVANFDDPYKGGILSPIRFGSQAAIDYVRWYSIGFQLVSFVILLLHGLYASILCLFNPGERTLLFVVLLTLAVGVSVVAGHDNLLMLWLPINYTWALKIRLLSLLWQTFFILLVFRRFSSAPPKNNLLRIYTVSLIAFSGLLLVAPAPLVNGMFHLGIFTVFYLFPFAWFIYIVGTMIFKKQTDNDSVFLMLSAAGIMCNFLWSLWDSIIREVTAVYYPIDIIAAIVGFSTYWFKKYFRNASENAKLNEQLQKADKLKDQFLANTSHELRTPLHGIMNIAQNVVAKEKEMLNERSLKDMELLITISRRMSHMLGDLLDVARLQEHRIVLQQEPLQIQSTVPGVIGMLKYMMESKPIQLNMDIAESLPPVMADEKRLVQILYNLLHNALKYTEEGTISISAETRNGHAIIHISDTGVGMDDETQERIFLPYEQGSYGISDGRGIGLGLSICKQLIELHGGTLTVRSEPGMGSVFSFELPLAASSSFPLSQPPLQHRQLANGMENEPVGSIFSYAAIGELAAAASLAPPLLNTGKVNILAVDDDPVNLNVLVGILSSGPYTITTAGSAREALDLLGTQSWDLLIADVMMPHMSGYELTHRVRKHYSVSELPVLLLTARSQPADIYAGFLSGANDYVTKPVDAMELQYRIRALTAMKQSMDERLRMEAAYLQAQIHPHFLFNTLNSIMALSDIDTKKMRQLGDAFTSFLRISFHFLNTGELVELSHELELVEAYLYIEKARFEDRLSIVWEVEPDIGLLLPPLSIQPLIENAVKHGLLSRSKGGTVKLRVIRQDGFTLIEVKDDGKGMEQDQVVQLLSATMKGKGGIGLSNTNRRLTQLYGQGLSIRSKPDEGTTVSFVIPDSRAEMQKKPISFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLK6</accession>
    <name>A0A398CLK6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosylmethionine:tRNA ribosyltransferase-isomerase</fullName>
            <ecNumber evidence="5">2.4.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">queA</name>
        <name evidence="6" type="ORF">D3H35_27695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:32155"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="2.4.99.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the QueA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.17" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00531">
        <property type="protein sequence ID" value="RIE00531"/>
        <property type="gene ID" value="D3H35_27695"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051075">
        <property type="term" value="F:S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00113">
        <property type="entry name" value="QueA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="PTHR30307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="SSF111337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00113">
        <property type="entry name" value="queA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="348" mass="38782" checksum="9C7D09695A49D73F" modified="2018-12-05" version="1">MNVSDFDFELPESLIAQTPLKERTSSRLLVLHRENGLTEHRSFTDLKSYLKPGDTLVLNDTRVLPARLFGVKADTGAKAEVLLLKRLEADRWEALVKPGKRIRKGTELHFGSDENGKPLLVAEVEEEGELGARTIAFRYEGIFHELLDKLGHMPLPPYIKETLDDRDRYQTVYAAHEGSAAAPTAGLHFTEPFLDELAQYGVKLCRITLHVGLGTFRPVSADTIEEHEMHAEWYSVSDESARLLNDAKASGGRIVAVGTTSARTLESIGQRFAPGQIEACSGWTDIFIYPGYKFTMVDAMLTNFHLPRSTLVMLISALAGREAVLAAYAEAVDRQYRFFSFGDAMFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM20</accession>
    <name>A0A398CM20_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flagellar biosynthesis protein FlhA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">flhA</name>
        <name evidence="8" type="ORF">D3H35_11465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03300">
        <property type="protein sequence ID" value="RIE03300"/>
        <property type="gene ID" value="D3H35_11465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042194">
        <property type="entry name" value="FHIPEP_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042193">
        <property type="entry name" value="FHIPEP_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042196">
        <property type="entry name" value="FHIPEP_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025505">
        <property type="entry name" value="FHIPEP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006301">
        <property type="entry name" value="FlhA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001712">
        <property type="entry name" value="T3SS_FHIPEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30161">
        <property type="entry name" value="PTHR30161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00771">
        <property type="entry name" value="FHIPEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005419">
        <property type="entry name" value="FlhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00949">
        <property type="entry name" value="TYPE3IMAPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01398">
        <property type="entry name" value="FlhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00994">
        <property type="entry name" value="FHIPEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="7" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="677" mass="74670" checksum="C92AF185A9EEC7D2" modified="2018-12-05" version="1">MKFRDLSILLGIIGIVLMMVVPIPKELLDILLVINISVALMILLISMNTQDALHFSIFPSLLLITTLFRLALNVSTTRLILKDHDAGHVVETFGRFVAGGQIAIGFVVFLILVVVQFIVITKGSERVAEVAARFTLDAMPGKQMSIDADLNAGLINEQQARERREKIEKEADFYGAMDGASKFVKGDAIASIIILVINLIGGFIIGMAIHGMSVTDALETYSILTIGDGLVSQVPALLISTATGIIVTRAASDGNLAHDVSTQLLRYPYLLYVVAGTVFLLGIATPIGFISTIPFSVILVIAGYRLQRNLVRRQQQEELLVEEKEIEEVRSPESVISLLQVDPIEFEFGYGLIPLADTHQGGDLLDRIIMIRRQCALEMGLIVPVIRIRDNIQLKPNEYIIKMKGNMVARGELLLQHYLAMSPGFDDDSVTGIETQEPAFGLPALWINEATKERAELAGYTVVDPPSVVATHLTEVIKKHAHELIGRQETKALVDSVKETYPALVEELVPSIMTVGEIQKVLSKLLKEKISIRDMVSILETLADYGKFTKDPEVLTEYVRQSLSRQITQQYAQASEPLKVITVSPAVEKKIAEAVQQSDQGSYLAMDPVSSQAIYQRLTEQVNRLIQSGQQPIVLTSPTIRMYLRQLLERSLNDIPVLSYSELEPNIEVQSVGVVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM73</accession>
    <name>A0A398CM73_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_25750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00967">
        <property type="protein sequence ID" value="RIE00967"/>
        <property type="gene ID" value="D3H35_25750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="11"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="150"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="217" mass="24456" checksum="28316517C700659A" modified="2018-12-05" version="1">MEAQGNGPFDKKGWRNRMTALRDTLDSDERRRNSALACRMVEDGILAPLRRRSDRPLTICLYGAFRSEADPELLFELALRAGDRIVAPRMVSSDSGRSLELREVRSMASFISGKWGVPEPDPARTTRYPESAPLDVVLVPGLAFDRFGGRLGYGGGFYDRLYAAETTGLREGTRWIGFAYSLQVTEERLPKESHDLRMDALATEKDVYWNSTWTEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMC1</accession>
    <name>A0A398CMC1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02369">
        <property type="protein sequence ID" value="RIE02369"/>
        <property type="gene ID" value="D3H35_16780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="97" mass="11019" checksum="6309AC4EAB1CA090" modified="2018-12-05" version="1">MEELPEYVNLSLRVKVPKDGRNSPYLLIGKLKVNRLADNDGVYGGELRLPRDIAFRFRITTDTGVQEAGRNGKEAPFRILKLPGDAAIDYEVERWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMF6</accession>
    <name>A0A398CMF6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_10050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03635">
        <property type="protein sequence ID" value="RIE03635"/>
        <property type="gene ID" value="D3H35_10050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="5">
        <location>
            <begin position="157"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="227" mass="24974" checksum="856A0710E9F9DDDA" modified="2018-12-05" version="1">MNGPIRVLLADDHRHARQAMSEIVGAEPDMEVVGEAASGEEAIELVDRLLPDLVLMDINMPGMGGFEAVKTIKGRHPPIKIVMVTVSDDAAHLFEALKKGAQGYLLKNLNPSAWRDYLRGVAFDEAPLNADLALSILREFSGRKPASASERARGEDGTVMQEGLTPRERGILQEVARGQKNREIAAVLGLSEHTVKNHLKNILQKLHLDNRVQLTRYAYEQGLVEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMM2</accession>
    <name>A0A398CMM2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03853">
        <property type="protein sequence ID" value="RIE03853"/>
        <property type="gene ID" value="D3H35_09890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="132" mass="14669" checksum="6CBF1AB698FE7817" modified="2018-12-05" version="1">MEKAVTFGDSRLVYDSASGLPLRWEKEDEALTTFVFPEPFVSLELNGISAANDAEQMIAIRNVMLTGARSELIHDEVKTVSEREKRLVIRTKIDGHWELTTTFLYCGDASLAVSVDVKTTNDSRNPVCAPYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMN4</accession>
    <name>A0A398CMN4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="7">GPI</shortName>
            <ecNumber evidence="7">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucose isomerase</fullName>
            <shortName evidence="7">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphohexose isomerase</fullName>
            <shortName evidence="7">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgi</name>
        <name evidence="9" type="ORF">D3H35_10550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03725">
        <property type="protein sequence ID" value="RIE03725"/>
        <property type="gene ID" value="D3H35_10550"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4 7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="449" mass="49750" checksum="A097BCC21729E2D3" modified="2018-12-05" version="1">MSKSIRFDYSKALQFVGQNEVDNLAPAVKLAHEQLHNGTGTGSDYLGWINLPFDYDKEEFSRIQKSARQIQSDSDALVVIGIGGSYLGARAAIEMLQHSFYNTLSKEQRKTPQIFFAGNNISSTYVTHLLQALEGKDWSINVISKSGTTTEPAIAFRIFREALENKYGKEAARKRIYATTDKERGALKKLATAEGYESFVIPDDVGGRYSVLTAVGLLPIAAAGIDIESMMKGAQDAATRFNNPNLAENEAYQYAAVRNCLYRKGKGVEILVNYEPGLHFVSEWWKQLYGESEGKDYKGIYPASVDFSTDLHSMGQFVQEGSRIIFETVLQVGEVAEQITIKSDPDDLDGLNFLTGKTLDFVNKKAFEGTLLAHTDGQVPNLIVQLPDQSPYTFGYLVYFFEIACGVSGYLLGVNPFDQPGVEAYKTNMFALLGKPGFEEQKKALEARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMT8</accession>
    <name>A0A398CMT8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02559">
        <property type="protein sequence ID" value="RIE02559"/>
        <property type="gene ID" value="D3H35_17890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="209" mass="23521" checksum="24B15824F1D075D3" modified="2018-12-05" version="1">MTIIAGKITSTLIGFLPLKVFLFSQDSNGQKRKAISSEDVYFKDKTLKTLKNYQGATLLDTYDYIYDPAGNQLKKTERVNGANKGETNYQYDDLNRLKQVTEPSGKMTDYTFDAFGNRSSERTTQGAAVTVLNYSYNEQNRLIATAEVKSTGDLQQVMFTYDNNGNMIAKSSEITKKIDPANVPTPTFGIFIYGQVNQNTRIALQVRWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNC6</accession>
    <name>A0A398CNC6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RHS repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03740">
        <property type="protein sequence ID" value="RIE03740"/>
        <property type="gene ID" value="D3H35_09285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1546" mass="175713" checksum="F4A9BB94C1A46904" modified="2018-12-05" version="1">MGIKHSNNDYCYFDKYGIYKKETNNSKYEFTTFYGYNVGYSRFQLDDGNTYTFASSTLLNSTYKNVTYSETKDDYVITVDDNVSYYFDRATMRIKMKRNKKGNFVTYTFKNYPSTSTLEKLTIDPLGQPFYVDILLSGKKVSGFQVFDRTNTLIKHVKYNVPRTTTTTPLTIRKLTRETTIAAGLAYYQLESVVDVLQNKTLKAYTYYNPTQTLADFNLEDDWKYFIDQNGNYILDVKDRNGNGVESAEVVRLNKGYYGEVAYLLLKEITDYTGFKTTVQYSTYDRSWPQYTDYEESEQKRGTIRSYGDLNLLQYIGYLPVVNVFYSYTDANGQTKIYTNNYQRDYSRAQEIWNRPKSVTPATTYLPAHRLVNASSYRNGDIQSSSMTQIYEGFSTSAKREFRVTSKGTFKLLWEKQINQLPQNNLNVTDGSNNISYSTENITAYQYDEGTNKPYLIKSLNGGQGNLVNDFGRSLPGNIANFANIQKLEYNDYGDVIYKEDTLGNKMTAQYDGIKHQVSYQSIVSADGKSKTENTFEYNTDSTIKKITTKQTYNDPATQLPVVKSSTEEYVSYNVRKMPTQVIVTADGSTQVINYLYDTRGFLVIKETVSVKLSDGTLKTEVSNSYTYDSLNRVTSQTYPDGSKVVYTYDSLNRKLSESFIPSTGGGTRTIQYTYDDSNRTITKILPDGEKIISTYTPYGTEEKIQRAIGSNTKVIQTKIFDSTGMVVKATLPYNDPTKGEYYSYGEDGQIQTVTNALGQSSNYYYSNSVTATDGSLSLPQMTSKTVDQDGKETWSYADRAGRVVKQVEKSGSKTRTTLQDYNGAGQVTKRQVISNGQLQTTWFEYDAVGNLIYVRDEKGQQYKYTYNSSNQLESISINGVLQNQKQYNELGWLLKSTNANGQAKNYQYRTNGLVEKVIDEEGQISNYSYTPYNEQERLSVKNATGTELYWLQNTFDPTSRLVTGITNSENETLTYRYDSWKHLDQQTVAGKKYSFAYDAFDRLSTVVYPDNAAVNYSYDALNRISTVSYPDMGVVSYGYNVSQNANKYTVTYPNGLVQEKLIDGFDELVSVTHSRSSSAPEWTESFGFDSFGNIETINRNGQIFNYLYDGLNRISTDVSSQKEYHYDDRGNIQSFEQNGQTYSFAYDNSNRLTQAALPSNTINFTYDNRGNRLTANSDTYTYNSLDQLKTFTNGTNQALYTYYGDGLRATKKVNGVLTRFVYLNGRVIDELDSNGNSKARNIWGNELIFRKDNATNQKGYYSYNGHGDVVRITDAAGTAINSYDYDIWGNITSQTEGMSNPFKYTGEIQDDESGLIYLRARYYDPSIGRFINEDSYEGQIDNPLTLNLYTYVGNNPLIYSDPSGHFWETIVDVMSIGWSAVDLWNDPSWSNAGFLAWDIAATIIPFAPGSYVLKVGKITFKSGEEATSYYNKLKKTQDITWSPYKNKHTLDSKVKWDKKAIQSTKTGSAKYKPGIDNEMLERITWDQGKIVKDSNGSTWKILEFDDIVGAYLGKETKYVVVKESGGTIHGHPISEEEAKAYLKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNC9</accession>
    <name>A0A398CNC9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04113">
        <property type="protein sequence ID" value="RIE04113"/>
        <property type="gene ID" value="D3H35_09225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="49"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="323" mass="37786" checksum="71F8494DAA7D1D4D" modified="2018-12-05" version="1">MADRTKAVTTAYFVTKFDLLKSEAGMNLSRLLERLRRHRPDPFPHKKVSVVIPNYNYEKYLRERLDTVFNQTFPVYEILFLDDASSDNSVSLFREYAAGNPRKQTAIRAFVNSSNSGSVFKQWMKGISLATGDYIWIAEADDSCSDVFLEKMMESFEADDQVVLSYAQSKQSDEDGQVYADDYTDYTNDIDMEKWKSSYIRKGLDEIRDTLVIKNTIPNVSGVVFKKFDIQEVEHRVTRYRIVGDLFFYVWLLQKGNIAYNHHSLNNHRRHSNSVAFKIDNKHVLYQEIVELQNELMEHFEIDSATLEKVYEYRAVAKKYSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNG2</accession>
    <name>A0A398CNG2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03780">
        <property type="protein sequence ID" value="RIE03780"/>
        <property type="gene ID" value="D3H35_09510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="123" mass="14040" checksum="EBAD968F921D87DE" modified="2018-12-05" version="1">MSIGTRIASLRDQRGWTQEELSSSLGISRAALSHYEKNRREPDADTLTKLADLFQVSIDYLVGRTFQPNMTLDTEVRQFADQLELSNADQLLDKFVLTIDGRQLTADEAKRFIAFIRAERSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNI5</accession>
    <name>A0A398CNI5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000021">
        <property type="protein sequence ID" value="RIE04926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04926">
        <property type="protein sequence ID" value="RIE04926"/>
        <property type="gene ID" value="D3H35_03475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="62" mass="7183" checksum="BE4069EE96A56202" modified="2018-12-05" version="1">MSRNKKVWIPAMIAAAIAALLVVYYYWTSAHGGERFARARWQGRDIVRRKMETNAMEAISRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNM5</accession>
    <name>A0A398CNM5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_16555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic sulfate-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02328">
        <property type="protein sequence ID" value="RIE02328"/>
        <property type="gene ID" value="D3H35_16555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902358">
        <property type="term" value="P:sulfate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005669">
        <property type="entry name" value="Thiosulph/SO4-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30368">
        <property type="entry name" value="PTHR30368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0574">Periplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017294168" evidence="6">
        <location>
            <begin position="24"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="205" mass="21837" checksum="6EFCA5882107B9F5" modified="2018-12-05" version="1">MNPRLIRKLSLTAVLSLSVTAFAACSSGSKSNGGAEEAAPTQSDYTKAVELVNASTDGTEPLYAELNAGFVLSWKSRTGQTVTVRQETGASSEQEQAIIKGDSKADVVTLGIGTDIDAIQTAGVVGKAGSNVTITIARLSIRRLHSSYAAAIRKAFWNGKTLSRTASLSLPRIRPLTPTPAGIMPRRGPTRWTQIRTIKKKRKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNY5</accession>
    <name>A0A398CNY5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_02905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05096">
        <property type="protein sequence ID" value="RIE05096"/>
        <property type="gene ID" value="D3H35_02905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="507" mass="59468" checksum="4133B669F2C77731" modified="2018-12-05" version="1">MIKIPFIYPNRDKYSADQITCLEKPLAIVSEGMKSQFSSYYYMLIKCFNLYRINKMENDRDLTHFNNLNSEVFRLLGIQLHFHSFDKNIDTLIREKIKLKQPVLVFGNMRELYYSNHYKKLDWIHLFLINGYDEERDIYSILDNTQKKNESHKLDEFILTAEMMRTLAFSSKETFGTTSVLSCERVQQHSDSVYLELLILCLKEIQDAPVENNEIVLMEFFQNGSEFHHMTVESLGFQLIRMNNFKEVLFTELINQLKRYLSDSAILTELEHLAKKLIQQWQSAINLFLVYYYRKGSTIDVRKLAGDAIETELSIKKLCSESLSLLYFNLQQQRHDKSESLWNEENNQDLVISLNDKSVVFQFEADLEFDFADCPKIFYKSPSVDFQNLLFKTKLTVHNPPRSAPFQAGIVFRTIDGETYIWGVFKNEQLVLSKTMDPLFSANIESKVAFLQLKYENHSYVFSYGDQNGVIRDAFKTDQIAEIDEIGFGSRNWGELKPMKLEFTLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP22</accession>
    <name>A0A398CP22_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03950">
        <property type="protein sequence ID" value="RIE03950"/>
        <property type="gene ID" value="D3H35_08290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="65" mass="7314" checksum="750A54ED7211C2EF" modified="2018-12-05" version="1">MPHLTLTSFVNQIANGNCSLPSYDQIHAGLKTSRPVQRAYFRDVRDDDDVGIDLRERLAARQLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP31</accession>
    <name>A0A398CP31_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04323">
        <property type="protein sequence ID" value="RIE04323"/>
        <property type="gene ID" value="D3H35_06890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="881" mass="97188" checksum="884E217F9D61009C" modified="2018-12-05" version="1">MSVDELVSELRQKIQENRYVVTDLSRLPEEEARFVQQLLPVDSLVLQEATLEADVQAVTITGYAALFQLERVEVKVSYTPVNGQNALRLSFRAAHAPGEAIPAAPWLEETLAKTDLAGPYFCSELELLAFKEQRLYSWQVRLASSRSLSAGADSLQLTDILVTLPYAQNAGAPAQLLISATAHAGELAFPLNAVLGDQTPEWSGALAALPLQSFIDSMCGPACYPIGAPDIHLSDSLLFLRKQEDGNYSLTLHHSSEMNGTYEIIIAPRLGNWHFTSGFLLPPNWDLTRFSCDLGPFSQLPLVGSTMYIASLDDSSFTLPRLAANHPAAHAGAKQGTWMYTGVLLNGHLMLKSLNILLNTQKLDAVARIKSDSTVVEWTASLQEKESYAIADSLEMTAFEVSGSSNRVDMTIHMEVAANVYGEKLVFAVETEFSLDPKDYLLPLQHTWKNPFGFSELNLAETKLRLELHPELRLTIESELPLSAGIAADSDLDQQSLQLACPVIGQELRDYFYGEYVGSLTLLQLVQTLNLEVAPAYLQEMTWSNSRLYLIGNPQGTSIEAASYNGRGLIITGTLDVIGIRSDARLFLDSQGQLKLEAEWPSFELGETLYVTGTEERPGPLLAITRETNGQWSGQIAGRITFFSESKDVLIQLSEYGIKTSFDGKLFHEFGADLQVHAPWGQAASGEFTVKGRLGPDFLNYVQRMIPELLNEKIESIGAQHKMADAAVDEQAQWIQSIEETIRRQENQHPSLSDDATATADRPFESPNSSSLDQLRASLEQAQTALEEGKQAAHSLKMEQGLLSALSLALPGLALFGQTVVTIREVGFEAGLQQLQHHTITLYADVEFIGQRFRPQFEFDFYDLAASVDNLLNELIVHFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP63</accession>
    <name>A0A398CP63_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00714">
        <property type="protein sequence ID" value="RIE00714"/>
        <property type="gene ID" value="D3H35_26315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="205" mass="24718" checksum="813CEDA8397ADC53" modified="2018-12-05" version="1">MIIQRTSLIYWFPQKPIKERCFYYDRVGISIGQLHAVLLVQELEPEDISGHIRQYIKYLRERGKYTVVNKEESKGKNHLESRNDFKKEVSMTTIANYIRNIKVFFNFLYQVEREIPKNPVENIENPKVERKVKKTLTPEEIKRGINQFERETFHGYRIYVIPIPRIFYWNVARRLLENARRHVRLALEYSREIHCPSVARSYKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPD7</accession>
    <name>A0A398CPD7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4291 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03179">
        <property type="protein sequence ID" value="RIE03179"/>
        <property type="gene ID" value="D3H35_17855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025633">
        <property type="entry name" value="DUF4291"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567">
        <property type="entry name" value="PTHR38567"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14124">
        <property type="entry name" value="DUF4291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="204" mass="23694" checksum="8E9D6FA04D51180A" modified="2018-12-05" version="1">MSVKSKNKSTENKRIHAQYDEKSIRVYQAYNYKIADEAVSLGTFGSHFKLGRTTWIKPSFLWMMYRSGWATKENQERILAIDIRRTGFDIILENVVLSAFKAEVYGQYENWKTRLENSNVICQWDPCRDILGNPLDERAIQLGLKGDIVNNYVNDWIVNITDITNTVIELGEAIKSKTFKDSMLPVEYEYPLNDRVKKILGIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPG5</accession>
    <name>A0A398CPG5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04473">
        <property type="protein sequence ID" value="RIE04473"/>
        <property type="gene ID" value="D3H35_05915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="26"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="254" mass="29306" checksum="A6CCA1F07AA4E76F" modified="2018-12-05" version="1">MEEMPYSEWMSFARKCWQTYGMPRTVVDLGCGTGNLSIPLARSGFQVFGIDLSSDMLAIARGKWDESSVRGLRSEEGSIRWLQQDMRDWELPEPVDAVISFCDCLNYLTDEDGVVDALRCTYDGLAPGGLFLFDVHAPSQLERYAEEQPFVYDEKDIAYLWTSEYEEEARVIRHDLTFFVREEAVGSGGGNGGGLYRRFEESHEQRAYEPEWITAQLERIGFELLHRCADFKWDEPDERSERLFYVARKPSRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPK7</accession>
    <name>A0A398CPK7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05336">
        <property type="protein sequence ID" value="RIE05336"/>
        <property type="gene ID" value="D3H35_00655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="94" mass="10338" checksum="55AF13E0A14EEE2D" modified="2018-12-05" version="1">MYMQVLNFTNVAKTENAELGKSIPIWVGKSTGKTLAEALGKIKETSQKSVYWGHVKVIVLTEDVLKRPINEVIEAITGTAKFGTTLTSSVRKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPM2</accession>
    <name>A0A398CPM2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04362">
        <property type="protein sequence ID" value="RIE04362"/>
        <property type="gene ID" value="D3H35_07135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="560" mass="60036" checksum="62DAFC615C0B3CC2" modified="2018-12-05" version="1">MKVIFKMRLKIHFVTIVNYDTIRTSDSYRKVFGQVERSKGMRRNRRKAVKTIVSLVAILVLSIAMALPAYAAIIDNGTVQLGINPEGHFNVEGGTESLPSDSTTAVGLRYIPTNGEATAPGCFCEGWGVANADAATGIFAGFANIATDGGAKGLVLLPETGVTDTADKTKEESEGSAFKSVVSAGGGRLKVTHHYKPSASPNLYEVEITVENTGKRPIGDLRYRRVMDWDIAPVTFSEFVEIHVGEASNVILATTDGFQSANPLSSPGPNIGTPPTTLHPGSPDYVARSASDQGSLFDFGFGELKAGEKKTFKTYYGAAENRKEALNALSAVGAEVYSFGIPSDPATGAPSLNGPHIFIFAFGEVGGDSVDTIAPTTTLVASSAKPAQANGWFSSDITVTLNAVDKLPGSKVDKTYYRIDGGAWKEYSAPFQFSSDKNYKVDYYSKDLAGNIELEKSTTLKLDKTSPVTRYGLQKIEAVNKKGTTYIAGFKVTLKPEDQLSGVSHTFYRINGGGWTAYTDPFEISANNTRTLEYYTVDNAGNVEISNVMDFVNGTFTGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPM6</accession>
    <name>A0A398CPM6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_06610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04485">
        <property type="protein sequence ID" value="RIE04485"/>
        <property type="gene ID" value="D3H35_06610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043723">
        <property type="entry name" value="DUF5665"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18910">
        <property type="entry name" value="DUF5665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="124" mass="13933" checksum="86E7B3C65C4D3615" modified="2018-12-05" version="1">MEHNNTGHHTDSSERKSSKLTEEARALKGTIHLLTDRLNTLASEMEKAQLKDYVNLMSRPWQLIWRNLLAGLSRGVGIAIGFTFFAATIVYILQGLGALNLPIVGDYIADIVRIVQRQLEINPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPT1</accession>
    <name>A0A398CPT1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="2">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tsaB</name>
        <name evidence="8" type="ORF">D3H35_25790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00974">
        <property type="protein sequence ID" value="RIE00974"/>
        <property type="gene ID" value="D3H35_25790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="7">
        <location>
            <begin position="49"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="275" mass="29692" checksum="CF42097849FAD6D4" modified="2018-12-05" version="1">MSERKAIDLGTNTGAERQPVTLLAFDTSTASLSVAVIRDGVAIGASQSFAERNHSVRIVSELKDIMRVSGIGREELDAIAVGQGPGSYTGVRIAVSAAKTLAWTWNKPLIGVSSLEALALGAHDTILLEPGEDERPDSEKRWIVPIMDARRGQVYTARFAAANDGSWERIDNDGIRLIESWAKRLLAEAENEGAGEVWFVGETAPHEAAIRQAADEYGRGRLLPFAMDAGALGRLAERRLSRGEADDVHSFVPNYTQLTEAEVKLLEASRQGGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPW4</accession>
    <name>A0A398CPW4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000004">
        <property type="protein sequence ID" value="RIE05456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05456">
        <property type="protein sequence ID" value="RIE05456"/>
        <property type="gene ID" value="D3H35_00385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="67" mass="7370" checksum="BE0C2CBEB5507BA0" modified="2018-12-05" version="1">MPRKSVFKVMDMKTGLSSGSRRAGSDHAVQPISREDTKIMNEIYGGQWSWNRKAVVVLAAVGGSPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ22</accession>
    <name>A0A398CQ22_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helicase SNF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_05465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04542">
        <property type="protein sequence ID" value="RIE04542"/>
        <property type="gene ID" value="D3H35_05465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013663">
        <property type="entry name" value="Helicase_SWF/SNF/SWI_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08455">
        <property type="entry name" value="SNF2_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="53"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="642"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="915"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1082" mass="123861" checksum="E81E729E5560F01B" modified="2018-12-05" version="1">MTEPLTLDAIRSLCGDLAFKRGQSYYKQKRVTRVERDPDSRLFDAVVIAEARFKVHLELDDGDVTHMSCECADFAESGTACKHIAAVLCHIQGMHRGQADRADGPFITNEHLFRARNLISIFDRPLPVSGGDEDVSDIRFDEPERLTVEFTCSALELGRKTSFAVEMKLGVKRLYIINKIKDLLRHWDNGTQMELAKLFTFDPSAQTFSEEDREVIELLSDIARNETAFRDAYMTYSYSRTLNEDRVLFIPPYAWSKLLPKLIAAKAKFVHGKMTYEALELKDEQVPLSFRFGHPTPDVYELSVTGLEHVTVMDTYSCVLIGSSLYRIHPSTVKQLGELKSMFFRSNEHHVLISPAHLELFLSRVVPGLKQLGEVDFSPELSDRIVTSPLQAKLYLDRNGDQLWATLEYAYGEVKLDPFATKNGKPVRADRILLRDGDKENRIMSLMEQIPFQYNGKVLHLDDEEDIYHFLFHTLPQLERWTEIYATPEARSMMRESVRPPKMTVDLDSRTDWLEVRFDMDGIDDGDIRDVLKSLVEKKSYFRLSDGRFLSLEDEGFSRIGQLLADMNLQASDVKDRYLQLSIARGLTFLDADERQQGLRLGQRFREFLANIRHPDQLQFDVPESLDPIMRDYQKLGFQWMKTLANYRFGGILADDMGLGKTLQGIAFILSELEASREAGTPALIVCPASLTYNWQNELKKFAPGIRSSVMSGDKSTREGLLAELADTDVLITSYPLLRRDASEYADRRFGVLILDEAQAIKNHSTLTAQSVQELKAKIRFALTGTPVENRLEELWAIFDAVFPELFWSKRRFNELTPEQVARKAGPFILRRLKSDVLTELPDKIETVQSSELLPEQKKLYLAYLAKLQEDTVRRLREEGLHKSRMHILAGMTRLRQLCCHPAMFLENYDGESGKLEQLLEIVDECRSAGKRMLVFSQFTQMLGIIRGELEKRDVPFFYLDGQTPARERVELCARFNEGEQDLFLISLKAGGTGLNLTGADTVVLFDLWWNPAVEQQAADRAHRIGQKNVVQVIRMVTQGTIEEKMYELQERKRNLIDAVIKPGEETLASMDEDDIRELLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ74</accession>
    <name>A0A398CQ74_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04360">
        <property type="protein sequence ID" value="RIE04360"/>
        <property type="gene ID" value="D3H35_07125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="147" mass="16664" checksum="01AB712143221018" modified="2018-12-05" version="1">MSDLLRADDIRQLIRSRGSLELPAHGKSMYPYLKEGQVCRFVPPSRLRVGEVILFVSRQGQLVGHRYHRELSPGCSPSILCKGDSNRNWDEPISPEQIVGRLAAVRNDNARVRRADSFVSFLWGRLIVAIPSLSFVIRLGMNIKKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ97</accession>
    <name>A0A398CQ97_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03479">
        <property type="protein sequence ID" value="RIE03479"/>
        <property type="gene ID" value="D3H35_12560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="35"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="314" mass="35042" checksum="23B91110013BE349" modified="2018-12-05" version="1">MNSIEMRSIEMKALIDEVVHAYFETPGYEIDSVPFGLTNVTKIVTIEADKYVIRIYNRHTKSVQSLELEAAITSFLSERALSFRVPEFVRSLSGNEYISMSDGTLGAVVTFLKGSAPELSSVRHAVDFGKVVGELSNALEQFEADRLSYRGKSFSEFYGLHPLADRAAVAAFIENPPFPIAEDQLLFYESMVSSIEKSAHLLKDLPTQLVHHDLLIFNLLADENGIRGVLDFDFVSVDARCMELAISLNHVLQMSGGSMEMAEAFVKGYAEQGKCTSPEIERLELLTRIYHIAVLHIYIGQHYSDMTLNEASIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQP3</accession>
    <name>A0A398CQP3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Urea carboxylase-associated family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03589">
        <property type="protein sequence ID" value="RIE03589"/>
        <property type="gene ID" value="D3H35_10955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018959">
        <property type="entry name" value="DUF1989"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017792">
        <property type="entry name" value="Urea_carboxylase-assoc_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09347">
        <property type="entry name" value="DUF1989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03425">
        <property type="entry name" value="urea_degr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1989" evidence="1">
        <location>
            <begin position="8"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="242" mass="27322" checksum="DB4CB391D22B670A" modified="2018-12-05" version="1">MNDEWSATIRPGGKWSGKIGRGKLLRFTALEAGANVSLLLYNADDLTERYNMPDTLKAQHTAHLTRGHTLMSDNGRVLAGIVEDSLGWHDTISAYTTREETDAKYGLSRYQENRNEWLRSGRENFAVELVRCGLGVRDLAPNVNLFSKVICDHAGEMRYDTKHCSAGATVTLRTEMDVVIVLSNTPNPLDPRTAYPSVPVKLEVRTATEAELANDQDYCVSFRPENRRAYENTWEYYSLQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQV1</accession>
    <name>A0A398CQV1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_10135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03649">
        <property type="protein sequence ID" value="RIE03649"/>
        <property type="gene ID" value="D3H35_10135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="229" mass="25426" checksum="5F961F8FB728A9FC" modified="2018-12-05" version="1">MKHLRNYPAEWLKGASLGEAVAGELRFRIVRGSLAAGAVLSENGIASEFGTSRSPVREALKALSAEGLIRLERMGAVVIGLSPKEIEELYDVRYLIESFVQRRLATGDLEPLIAKLSRIVDKMELAAKHHDVSEFSAQDFSFHETIIAESGHSRIWQMWKGISQVVLIVMLITTEEVFDSGDERVGAVISKHRTIVHVLSSKDESKIESAVRDYFSDSFVTLKSSIPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR11</accession>
    <name>A0A398CR11_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF98 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_03280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04973">
        <property type="protein sequence ID" value="RIE04973"/>
        <property type="gene ID" value="D3H35_03280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002800">
        <property type="entry name" value="Rv2949c-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01947">
        <property type="entry name" value="DUF98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="174" mass="20322" checksum="FA3A7C16EC80AF59" modified="2018-12-05" version="1">MLRTSTDGAVVRMLLRSDGSTTLLLESLLDRKLTVEVTGQYLASREEIHPDILAHLQTESTDRLYIRRSALQTDERIKVSFNYLVMRVPLGQENLYETLCTRDIPLGKQIANNRIEHHRHLIGDGRIEQEIDGRKRVCYFKHYLLELSREPIFYIHESFHPDYLPVEDTFAIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR42</accession>
    <name>A0A398CR42_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplY</name>
        <name evidence="6" type="synonym">ctc</name>
        <name evidence="9" type="ORF">D3H35_23790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01394">
        <property type="protein sequence ID" value="RIE01394"/>
        <property type="gene ID" value="D3H35_23790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="8">
        <location>
            <begin position="100"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="214" mass="23320" checksum="7A9ADDA658651BBA" modified="2018-12-05" version="1">MNQVLQAELRDTKTSGQLRGVRESGKVPGVIYGAGIAKPTAIAVEAKELLAILRSHPHAVVDMNVPGLGNQPVMMTDVQRDPMSHKVLHIDFHQIDMNRKIKAPVRLDASGKSPGEQEGGMLQFVMHELEVECYPKDFPDVIHVDVSGLQLGDNLTIADLKLPDSVQAVADAEAVVVSVLAPQKERTADELDALDDEEEENENHRKAAVAVEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR76</accession>
    <name>A0A398CR76_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prephenate dehydrogenase</fullName>
            <ecNumber evidence="4">1.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_04000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:13869"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.12" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04660">
        <property type="protein sequence ID" value="RIE04660"/>
        <property type="gene ID" value="D3H35_04000"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00122">
        <property type="reaction ID" value="UER00961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="311"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="379" mass="40866" checksum="505123D503A92B05" modified="2018-12-05" version="1">MSGDFSDFTFEQSEGTKIKIAIFGVGLIGGSLALCFKGNPGFHVVGHSVNPASIDKYIASGVVDEATTSLADAAADADFLFLCVPVGRLSDYVEELSRLSLKPGCIITDVGSTKASVVRHADKLALQGAVFIGGHPMAGKERSGVEAADVHLFENAYYVLTPTEATPAEALARLEELLHWTRAHIVKTDAVLHDDVVGAISHLPHVIAVALVNQIAGYNEENGLYASLAAGGFRDITRIASSEPVIWRDILLNNRDVLLKLLGDWKEETDKFVDLLERSDGEGIAEQFRAAGEFRNSLPERRKGLIASLFECYVNVPDHPGIVGGIATELGQARINLSNLHIIESREDVPGVLRLSFRNEAALEQAVALLKSLGYDVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR90</accession>
    <name>A0A398CR90_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmH</name>
        <name evidence="7" type="ORF">D3H35_24010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01434">
        <property type="protein sequence ID" value="RIE01434"/>
        <property type="gene ID" value="D3H35_24010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="44" mass="5053" checksum="0476747FF0C9510A" modified="2018-12-05" version="1">MGPTFKPNVSKRKKVHGFRSRMSTKNGRKVLKARRQKGRKVLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRG3</accession>
    <name>A0A398CRG3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02011">
        <property type="protein sequence ID" value="RIE02011"/>
        <property type="gene ID" value="D3H35_14695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="254" mass="28691" checksum="C2FE696FEE845E9F" modified="2018-12-05" version="1">MVHKQFYVIGRRGNKAPTVTISGGRVSNRRNKTLSVTISDGLMGIRGNKTLTVTISDSRVSIRGNKAPSVTISDGRAGIREIRHPQLLFPAVGWAFEEIRHLQLLFPAVGRALEEIRHPQLLFSAVGWAFEEIRHPQLLFPAVGWAFEEIRHPQLLFPAVGWAIAEIRHPQLLFPAVGWAFEEIRHPQLLFPTFRWAFEEIRHLQLLFPAVGRALEEIRHPQLLFPAVGRALEELRHLQLLFPAVGWACGVSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSA5</accession>
    <name>A0A398CSA5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_16145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02261">
        <property type="protein sequence ID" value="RIE02261"/>
        <property type="gene ID" value="D3H35_16145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="14"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="137"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="329" mass="35756" checksum="FFB0D78DAB23060D" modified="2018-12-05" version="1">MIRIGMLSYWHVHAEDYTRQVLEHPQTEIAAIWDERPDRGAEKAAKYGVPFVASLEELLAREDIDAVVVDAPTNIHKDVMVKAAKAGKHIFTEKVVALTLAEANEITGAVKQAGVKFAVSLPRLYDSYTQTISGVVGEGLLGKLTLARVRLSHNGSTANWLPAHFYSKEQCGGGALVDLGCHPMYLVRLFLGLPESVHANYGYVSGREVEDNAVAVLSYPDGAIGVVEAGFVNSHSPFSIELHGTDGTLLFGFPEEKVLVRSSRKGEGWIEVPAADRLPFAFSQWVGHILEGTEAARNVELAVDLTKLMEASNRSVAEGRPILLSELEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSE5</accession>
    <name>A0A398CSE5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000002">
        <property type="protein sequence ID" value="RIE05473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05473">
        <property type="protein sequence ID" value="RIE05473"/>
        <property type="gene ID" value="D3H35_00145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="167" mass="18285" checksum="E87B4A76A8015BE2" modified="2018-12-05" version="1">MLKNSKSKNTSFQALYFVPGMELRFKWLPILIAFLLLLGSVGTYFSLPKGAIDNSSASSLSITLDYKPDTPVDEVRENGLKLEKFLMEQEGQDYVDMQMGNSADGATYGNVNSPTLVSYTVQMKDGADADKIIDAVKGQRANYPGADLNAGPARFSAEAHLRKYSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTE6</accession>
    <name>A0A398CTE6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_21265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03107">
        <property type="protein sequence ID" value="RIE03107"/>
        <property type="gene ID" value="D3H35_21265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="73"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="277" mass="30689" checksum="55AD94B0A3163C2D" modified="2018-12-05" version="1">MNTIIYRRKLGKVSLNSVTIVLILLTLFPLLWLFLTAIKQPIDAFAMPPKWIFEPTSDNFLAVLTKSEFVKSYVNSLIVVTGTTVLSLWFGIASGYTLARSKSRFSNAMGMWIILARMAPPMGFVLPLYLMFSKIGILDTYFGLILVYLTVTLPFVTWLMVGFIKSIPIEIEEASAIDGCNRFQTLIRIVIPSSLPGISTCAIFAFIMSWNEFFYALIISGRNTRTASVEIQGFINFAGINWGELAAAGVLVVVPVLIFTIFAQKGLVRGLTQGATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTI1</accession>
    <name>A0A398CTI1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YtxH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02621">
        <property type="protein sequence ID" value="RIE02621"/>
        <property type="gene ID" value="D3H35_18235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024623">
        <property type="entry name" value="YtxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12732">
        <property type="entry name" value="YtxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="107" mass="11615" checksum="C5B8A14222A3CF50" modified="2018-12-05" version="1">MNMAANKGMFKGALIGGAVGAATALLFAPKSGRELRSDIKNRYIDAQDRTKQFVSDVTSKAKDTVSQVGDQASDLVGKTRSAIRSAKDELETWKEDRKEEQAQKSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTN1</accession>
    <name>A0A398CTN1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04068">
        <property type="protein sequence ID" value="RIE04068"/>
        <property type="gene ID" value="D3H35_08975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="119" mass="13813" checksum="B68B2BED98FD2FAB" modified="2018-12-05" version="1">MNEPASSASPAPTSRRKTAEVHSLLETLILKRESEIAEIEQMVDRYERRLRMEQQAYRTMSPIRRMLAGKKPDHHLALEYIHYVKKPMERVHSLREEIGKYRAMLDGTVPAELPSSLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTP6</accession>
    <name>A0A398CTP6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chorismate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.151</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Menaquinone biosynthetic enzyme MqnA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mqnA</name>
        <name evidence="4" type="ORF">D3H35_03930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>chorismate = 3-[(1-carboxyvinyl)-oxy]benzoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:40051"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:76981"/>
            <dbReference type="EC" id="4.2.1.151"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MqnA/MqnD family. MqnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.151" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04649">
        <property type="protein sequence ID" value="RIE04649"/>
        <property type="gene ID" value="D3H35_03930"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00995">
        <property type="entry name" value="MqnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003773">
        <property type="entry name" value="Menaquinone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030868">
        <property type="entry name" value="MqnA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37690">
        <property type="entry name" value="PTHR37690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02621">
        <property type="entry name" value="VitK2_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="293" mass="33069" checksum="D730417D39CD7B80" modified="2018-12-05" version="1">MSSKLHRPIRIGRIDYTNVWPVFHHFDESALACEAEIVREMPAALNRKLRAGEIDVAAISSFAYGQSSDRYYLLPDLSVSALGRVQSILLFLKSPLEKAIHGKIALTTTSATSVNLLKIIMEKFYGGKPVYEDAEPSLDRMLEHADAALLIGDHAIRASWEKRGYRVLDLGEVWNVWTGHWMTFALWAVRRETADSRPDAVRSIYEALLASKHASESDREPIIRKAINQIGGTRSYWEGYFSNLHHGFAKEQQAGLALYFQYARELGLMDGQPSLTEWPEAKAAYSRKSQVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTR7</accession>
    <name>A0A398CTR7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquinol-cytochrome c reductase iron-sulfur subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_04045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04669">
        <property type="protein sequence ID" value="RIE04669"/>
        <property type="gene ID" value="D3H35_04045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="7">
        <location>
            <begin position="98"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="178" mass="20132" checksum="229F48FD85723742" modified="2018-12-05" version="1">MDHNEQQDTVHKPIKRKEMSRRQFLTYTLGGATAFMAGGVILPMIRFAVDPILQKKTSGNFVKVIEESKVTKEPQQVDFKVHQIDGWYESDPKMQAWLTKGDDGKVFALSPICKHLGCTIGWSGEEAPNEYHCPCHGARYTKDGKNLKVAPKPLDEYEVKLENGWVYLGPLLANTRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU50</accession>
    <name>A0A398CU50_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03387">
        <property type="protein sequence ID" value="RIE03387"/>
        <property type="gene ID" value="D3H35_11970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="3"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="240" mass="27194" checksum="FCA32121DE14C0EE" modified="2018-12-05" version="1">MRRTLIVSDIHGCVDQLDELLLAVSYNPVADDLILLGDYVDRGPKSKESVERVMQLVENDGAVALRGNHDQRFADLIRADSEELTAKFLEHGGIQTLQSYCDLTGDQVVDPEVIRSARAHVSHNYSRHIDFLRSLPLFHEDRNHIYVHAGLNPNFKNWRDQPEHDFMYIKKEFHQAKLSVGKTVIFGHTRTVELQQSPDVWFGDGKIGIDGGCAYGMQLNGLIYYEGVYSTVSVPNNRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU86</accession>
    <name>A0A398CU86_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">M20/M25/M40 family metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_12115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03407">
        <property type="protein sequence ID" value="RIE03407"/>
        <property type="gene ID" value="D3H35_12115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="359" mass="38913" checksum="1C409865B84F3CEF" modified="2018-12-05" version="1">MTEGKLDPARPLSPGLDKDYVLGILEKLLRTPSPSGFCMEVMSVVEEEVRKLGYEMETTPKGNGIVTITGVGGGAALGLTAHVDTLGAMVRSIKPTGMIRFTPVGGYSMHTVEGEYCLVHTRDGRSYEGTVLSTKPSVHVYSDMRDLKRVEENMEIRIDESVRTKEDVEKLGISVGDFISWDARTRILPNGWVKSRHLDDKASVAALFGLLKWLKRSGSKPSRNVKIIFSTYEEVGHGSSYLPPDIDEMIAVDMGAIGDDLQTTERDVSICAKDSSGPYDYGMTTRLIELAKREGIAHAVDIYPHYGSDASAALRGGSNIRAALIGPGVHSSHGMERTHADAILGTASLLLAYVMQPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU96</accession>
    <name>A0A398CU96_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_05070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04839">
        <property type="protein sequence ID" value="RIE04839"/>
        <property type="gene ID" value="D3H35_05070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="92" mass="10454" checksum="C40FCF110D2CEABB" modified="2018-12-05" version="1">MNLYERSIVELLSSEFGYSAGDARALVVRYIQVIRKLGAYDNSRDQAERLAEADAKSYSPEAWLERLAASERERAYDKGLPHEKGTIFANVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUF5</accession>
    <name>A0A398CUF5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_18250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02624">
        <property type="protein sequence ID" value="RIE02624"/>
        <property type="gene ID" value="D3H35_18250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="295" mass="33235" checksum="F8B38888406B8C19" modified="2018-12-05" version="1">MDFVFLKSFIEVARCNSFTKAAESLGYVQSSVTSHIQKLETEYGVLLFERYGRTVRLTSAGEQLKETFERILQLYDDSLAVISRQVKGHLDIGTIESLMAFFLPQVFHRFRQTYPQVCLQALPLSETQILHQVKSGDLDLGIVLDRPIKDDDVEAIILREEPLVLVSAPDHPLCGAHHLEVSQLVGQSYVATENGCTYRAAFEGLLGRHGVSYHIHHEFGSLEAIKQCVSYGLGIGLLPRIALERELAEGRLVSLPFRHAEMTVYSQVIHHKKKWFDPAIRHLVDLLKETARSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUN6</accession>
    <name>A0A398CUN6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_03260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04969">
        <property type="protein sequence ID" value="RIE04969"/>
        <property type="gene ID" value="D3H35_03260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="816"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="891" mass="100193" checksum="9A771694D5CB5B85" modified="2018-12-05" version="1">MICYSSNREEVFVLDQYAVNVLLSSGELDEEKEYWLSKLKDETTKTEMPPDYPLGKYSDYQKGSVTSFMPYELTSKINKLSNHSDLGAYIVMLSAVMYVLHRYTGSRYVVTGTAVLKPQIPEPDVPINRLLPLRCNAGDSPDFRHWLKEVQNTLAEAGNNQRFPLDHIWRTLYPNENEAKPEFYHTAVVMESLHDQSFLDDEVPLNQVFCFFKEGSDIGLTIHFNANLYAADSMKRFVSHFANFLNAAIDTPEQPLSDIEILSVEEKKQLLFDFNDTRVEYSAHKKVHQLFEDSVRMSPNRVALLMDSDTSITYAELNRKSNQLAGKLRHLGVTEGSFVAISMDRSFEMIISLLAILKAGGIYVPVDESAPLSRTNRIFLRLGIRHVLIGNSQNGWIKQISHELPELDCVLQVSLYSNPICEAVDNCVSLCTNDQLIAYSDEDLQVELSRHPYAYVIFTSGSTGEPKGVLVEHGPIVNLIEWVNHTFEVSEKDRLFFITSLSFDLSVYDIFGILAAGGSIRIATNEELANPYAMFEALCTESITFWDSAPAALQQVLSYSLEDRTGPSLRLVFLSGDWIPMTVPGTVKAIFPHARVISLGGATEATIWSNYFPIDSMDARWTSIPYGKPIQNAQYYILGDQFQPSPIGVPGKLYIGGVCLASGYIGDPELTNAKFKANPFIENQRIYDTGDLARWLPDGNMEFLGRVDHQVKIRGYRIELGEIQIQLAKFPSIQSAVVIDREDQTGTKHLCAYFVSEDRISSFVLRRYLTDLLPGYMIPSYFLQVDQMPVTSNGKLDRKALPVPEGGVESDCEYEAPGDELESMLAEIYGEVLGISRVGVNDNFVQLGGHSLKATTLVNQIQKKLNVQIPLWKVFDSPTIRELANSIREMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUR7</accession>
    <name>A0A398CUR7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02744">
        <property type="protein sequence ID" value="RIE02744"/>
        <property type="gene ID" value="D3H35_19055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="133" mass="15158" checksum="BB2B2F22BE737594" modified="2018-12-05" version="1">MGLSDVSLARQVDIALEKLEGELKGLTAGTIVLQIREDTIGKFGIRHLPMDCEEDSSIHSGGMTEAHVRLLRRMAVDALKRKRGWTYGEILYDFGLKRGKVYVSVQFESNYNMANLMFRFTPKRRDHREIAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVA1</accession>
    <name>A0A398CVA1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rfbD</name>
        <name evidence="4" type="ORF">D3H35_09750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03827">
        <property type="protein sequence ID" value="RIE03827"/>
        <property type="gene ID" value="D3H35_09750"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="5"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="290" mass="32511" checksum="A886D3396A290CCD" modified="2018-12-05" version="1">MERKRIAVTGAGGQLGRDLCPLLERSGYDPIGWDRSDLDITDAQAVMRKIEEFRPDAVVHTAAYTKVDQAEKDSEAAYSVNAVGTRNVALAAEAVGAKLVYISTDYVFPGTGRDPWHESRETEPLNVYGHSKRAGEWIVSSVHSRWFVARTSWVYGSHGHNFVKTMLHLAGEKDVLEVVNDQVGCPTYTVDLSQAIIRLLESEKYGTYHVSNSGQCSWFEFAKRLFELAGVSVQVNPVTSERYPRPAKRPAYSVFEHRALKANGFPPMRPWEEALSEFVTHYSDKERRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVE8</accession>
    <name>A0A398CVE8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_20440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02974">
        <property type="protein sequence ID" value="RIE02974"/>
        <property type="gene ID" value="D3H35_20440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041617">
        <property type="entry name" value="TPR_MalT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17874">
        <property type="entry name" value="TPR_MalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="811"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="878" mass="95880" checksum="3522882D57CE05B5" modified="2018-12-05" version="1">MTMPILSTKLYIPPPRPNAISRSRLTERLNEGLHRKLTLVSASAGFGKTTLASEWIAGCGRSAAWLSLDEGDNDPARFLTYLTAALQTIGTNVGESVFGMLQSSHSPPIESILTALLNEIHANPNPFVLVLDDYHVIDANPIDQALVFLLERMPPQMHVVVATREDPQFPLARLRVRGQLTELRAVDLRFTLTEAAGFLNQAMGLHLSPEDVAALETRTEGWIAGLQLAAISMQGHKDAAGFIKSFTGSHRFVLDYLVEEVLQQQSDSVQAFLLRTSVLDRMCGPLCDAVQRPDDSTSGQETLEALERANLFIVPLDNERRWYRYHHLFAELLRQRLSQSAASSAGGKGSGAAELHICASIWYEDNGLEIEAFQHAAAANDIERAARLVEGKGMPLLFRGAVGPVLNWLESLPATVLTAMPSLLAMHASALLLIGQLPAVEQKLQAAEAALQGVELDEKTRDLVGHIASIRAAIAVSQHQVETIIAQSRRALEHLHPDNLPVRTATTWTLGYACQLQGDRTAANRAYTEAISISQTIGHLIILVSATIGLGSLHQSENRLGLAEQTYRRALELAGDPPMPIACEAHLGLAKLAYERNELDAAEWHGQKSVQLARLIENTDRFVACDVFFARLKLARGDAAGAAALLAKAGQLARQHRFMHLMPEIAAIQALALLRQGNPTAAERLAREYDLPVSLARVRLAVGDTSAALAALEPLRRHAEARGWEDERLKVMILQAVALYEHGDKGGAVRLLGDALALAEPGGFIRLFVDEGVPMARLLIEASARGIRTDYAAKLLAVFEAASLSRPLPLAQPLIEPLSERELEVLRLISEGLSNHEICERLFLALSTVKGHNRTIFDKLQVHRRTEAVARARELGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWK3</accession>
    <name>A0A398CWK3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03404">
        <property type="protein sequence ID" value="RIE03404"/>
        <property type="gene ID" value="D3H35_12085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="87" mass="9893" checksum="7CBDF3BAC92E47DB" modified="2018-12-05" version="1">MRMMTLDRLDDRWWPQAHRIYDGAFPHGRKPDSVISAMFDRRMAHLHLLIKDGDGDPELLAMAISGTTGNLLLIDYVAVSEDARAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWZ8</accession>
    <name>A0A398CWZ8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAGPA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03534">
        <property type="protein sequence ID" value="RIE03534"/>
        <property type="gene ID" value="D3H35_10815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAGPA" evidence="1">
        <location>
            <begin position="59"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="223" mass="24056" checksum="99A90AE7784DAD61" modified="2018-12-05" version="1">MPRDYAYATVTATNGVKLHSLRTRPSNAVPEVSRNNVTLTSFYGINGGFFYQNDLLSIAVVNDRPVGGAAAKYGSGAENVKYARGTLVWDGKTEGMSVQVVRASADLQVTDRSSYWAQGGISMGLGRDGEWLGQAAAENAPFPDDERLRSAAAYDEEGNLYLIVSENRGTLADFREAIVETVGGGKLVDGIFLDGDGSSQLNSRERKLQGDGRPVVEMLRLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXA1</accession>
    <name>A0A398CXA1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000034">
        <property type="protein sequence ID" value="RIE03624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03624">
        <property type="protein sequence ID" value="RIE03624"/>
        <property type="gene ID" value="D3H35_10640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="399" mass="45215" checksum="6E119BF11387105E" modified="2018-12-05" version="1">MGTTEKAASAECFTSCLSAAQRNWQICKRNSFSLDTSVQCQMLFEKARLRYFCLEPSDREAVAETMVYFKRLQQKTSPFEHMQAGSTLEKLWSKYEQRIAAAGSVPIFKDLHRKTVLYLDRLSQGLDYYGYKYNHVPVVSFDFCREQLDALIANFKTIQEEYALQLEALQDVTRAKSALAAARRQAEFTVRSHKAKINKLVVMLGDTARTIDNYTPYMARKKAIVEERIESFKAKLEKHFDWNWDNIFSSLGSIAFAPTSSVMWITHGAKIAFDGKTKVTGADDDTINEAYLVNRLKTITKDFQSLKEGYSAMPGGSLQPDDPGAAKLVGDAEAIESLLRQVSDQIDSTELREALHDYVQTVIDRNGHIMTYNATPYSCFRRSTSSRSWKAPLNGLISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXG5</accession>
    <name>A0A398CXG5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Ribonuclease J</fullName>
            <shortName evidence="9">RNase J</shortName>
            <ecNumber evidence="9 10">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnj</name>
        <name evidence="13" type="ORF">D3H35_01805</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9 10"/>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05278">
        <property type="protein sequence ID" value="RIE05278"/>
        <property type="gene ID" value="D3H35_01805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001587">
        <property type="entry name" value="RNase_J_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004803">
        <property type="entry name" value="RnjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01292">
        <property type="entry name" value="UPF0036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="12">
        <location>
            <begin position="20"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 11">
        <location>
            <begin position="366"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR004803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR004803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE05278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="560" mass="61319" checksum="6141DBFF845C646B" modified="2018-12-05" version="1">MNEVANRLSIIALGGVHEIGKNMYVIQYDDDIIVVDCGSKFPDESLLGIDLIVPDITYLLENQNRVRGLVVTHGHEDHIGGIPYIIKQLNMPIYATRLTLGLIKIKLKEHGLLGTTTLHQIDSDTRLRLGSVSISFFSTNHSIPDCLGIAFHTPQGTVVHTGDFKFDLTPVNNQFADIHKMAEIGMNGVLALLSESTNAERPGFTPSERLVGGHIHEAFTNADGKIFITTFASNVHRLQQIIDAATAVNRKIVLLGRSMVNVADVASSLGYLNIPSNMLLDVAEAGNYRRDELVILCTGSQGEPMAALGRIAGGNHRQIEVNPGDTVIFASSPIPGNERNVARIVDNLFAKKAKVIYGPGSATGMHVSGHASQEELKLMLTLMKPQYFIPIHGEYRMLHQHRLLAEAVGVKASNIFIVNNGDVVDIVGSEAIQERKVPNGNTFVDGLGIGDVGNVVLRDRKVLSADGILIIVLTLGKSDNKIVSGPDIISRGFVFVKESEGLLEEVHRITLKEVEQLQQEYAKMNNSWSIYKQTIKDSVGKFLYAKTKRRPMILPIIIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXJ0</accession>
    <name>A0A398CXJ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore coat protein CotJC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the manganese catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03941">
        <property type="protein sequence ID" value="RIE03941"/>
        <property type="gene ID" value="D3H35_08225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01051">
        <property type="entry name" value="Mn_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007760">
        <property type="entry name" value="Mn_catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039377">
        <property type="entry name" value="Mn_catalase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05067">
        <property type="entry name" value="Mn_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="189" mass="21584" checksum="148658E93E9BD735" modified="2018-12-05" version="1">MWIYEKKLQYPVRVGKCDPRMARYLVEQYGGADGELSAALRYLNQRYSIPDRVIGLLTDIGTEEFAHLEMIATMIYKLTKDSTPDQLEAAGLGANFVNHDGGMFYNNAAGVPWTASYIGTKGDPIADLYEDIAAEEKARATYQWLIDITDDVDLKDSLKFLREREIVHSFRFKEAVEILKADREQKKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYM0</accession>
    <name>A0A398CYM0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF350 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_09120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0719 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04094">
        <property type="protein sequence ID" value="RIE04094"/>
        <property type="gene ID" value="D3H35_09120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007140">
        <property type="entry name" value="DUF350"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03994">
        <property type="entry name" value="DUF350"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="139" mass="15358" checksum="FEC7F2D9A5F91E35" modified="2018-12-05" version="1">MKNVVDQLMAEPIVAVLAYFSVGILALIVFLSFFEKVTKYDGWNEIRKGNLSVAMATGGKIFGICNIFRFSIEANDTIYESLLWSAVGFMLLLAAYFLFEFLTPVLKIDDEIAKDNRAVGLLAMIISVSLSYIIGAAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYN3</accession>
    <name>A0A398CYN3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative NAD(P)H nitroreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_07000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nitroreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04341">
        <property type="protein sequence ID" value="RIE04341"/>
        <property type="gene ID" value="D3H35_07000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02135">
        <property type="entry name" value="YdjA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026021">
        <property type="entry name" value="YdjA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000232">
        <property type="entry name" value="YdjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 3" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="137"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="190" mass="20879" checksum="10B71347D8EFAFFA" modified="2018-12-05" version="1">MNVEEAIRTRRSIGKVKDEPVPRELLERMLEAAVWAPNHHQTEPWKFVVMTGEGRKTLGRAYAEIASGHSPNLSEQERAELHKREEAKANRAPVVIAVVCSPSEAPRVSRAEEFAAANSAVQNLLLSAHASGLGAVWRSGDPMYHPAMKSAFGLQPQEELVGLVYVGYPDLQPPEGKRIPAASKTIWIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYR2</accession>
    <name>A0A398CYR2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ca(2+)/H(+) antiporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cax</name>
        <name evidence="7" type="ORF">D3H35_07200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Ca(+)/H(+) antiporter that extrudes calcium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04371">
        <property type="protein sequence ID" value="RIE04371"/>
        <property type="gene ID" value="D3H35_07200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="PTHR31503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="30"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="207"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="352" mass="37939" checksum="1926A2FFC431C982" modified="2018-12-05" version="1">MKKLFFPLLIATFILSGLSHYMHWGPITEFVISAIAIVFVAGFLGKATEAVAHYAGQRLGGFLNATFGNAAELIIAFFLIKEGMFDIVKASLTGSIIGNLLLVLGASALAGGLKFKEQKFNIHLAGQNASLMLLAVIALFIPAIFVKTEHIPEKDTLMLSLIVSGALILAYVGWLIYSMITHKDMLEDQEETQPAHGEEPAWSKGKAILYLVLATVMVGFVSEWLVHTLDTFTTKFGLSELFIGAFVVAIVGNAAEHSAAIMLARKNKMGAAVEIAVGSSLQIALFVAPVLVFVSMFFKDHMNLIFTTVELAAIGVAALIATSISRDGSTTWYEGKLLLIVYAILGVAFFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZP8</accession>
    <name>A0A398CZP8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05337">
        <property type="protein sequence ID" value="RIE05337"/>
        <property type="gene ID" value="D3H35_00665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="79" mass="9348" checksum="AA4CEEBECE017B15" modified="2018-12-05" version="1">MLVDMLPIRSSSKASRRNWLIIAIIFSFVIISMIPVNEYTFYLWMYEYYFPISLLVVMSVFFVWLFISLLGRPAKKEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0E1</accession>
    <name>A0A398D0E1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_03170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04951">
        <property type="protein sequence ID" value="RIE04951"/>
        <property type="gene ID" value="D3H35_03170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="226"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="776" mass="86976" checksum="2AB913274F6636EE" modified="2018-12-05" version="1">MGKNKIIHVYGPTESTVFATYYEVNEVAEEDVNVPIGRPIRNTMLYVLNKTNRLQPIGVPGELCISGAGLARGYLNQPELTAEKFVANPFAPGERMYRTGDLARWLPDGNIEYLGRIDEQVKIRGHRIELGEVESALRSHESVKEATVIARKDEEGSAYLCAYFVANGNLGAAELRKRLSEMLPQYMIPSFFVRVEQMPLTPNGKLDRKALPSPEGTLERGTVYEAPRNALEETLANIWQGVLGVSAIGIADNFFELGGDSIKAIQISARLHAHHLKMEIKDLFQHPTIGELSSCLRPVGRTIDQGLVEGEVELTPIQRWFFEQNFTDRQHCNQAVMLHRKDGFDERIVREVLAKLAEHHDGLRMVYHPGSEGYTQRNRGMEGEVFHLEVRDVTGDQQAEEEVIQACATEIQASMDLGKGPLLKAGLFKTAEGDHLLLAVHHLVVDGISWRIVLEDLNTGYRQAMNGEAIRFPTKTDSYQAWAKALQGYANSGQVLEEAEYWQAVERAEVKPLRKDSEVGAGLMKDGRHVSLTLTEEQTEKLLKQVNKVYNTEINDILLTALGLAIGEWNDSKQAAIELEGHGREEIGHEVDISRTVGWFTTQYPVILEMEQSRELSYQIKTVKEHLRRVPNKGIGYGLLKYGKAAAEGRTWKLKPEVSFNYLGQFDQDVETGLFAGSRYGAGGSVSPNVERTSTLSINGMVLGGHLQLTIDYNGKAYEADTIESWQPGTSVIWKPSSSIVRIEERRKKRQAIYCSTNCPSKRWIKSTRHSCMWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0F7</accession>
    <name>A0A398D0F7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04971">
        <property type="protein sequence ID" value="RIE04971"/>
        <property type="gene ID" value="D3H35_03270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="72"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="412" mass="45622" checksum="FA0A67E01C35112D" modified="2018-12-05" version="1">MDFEYKVKDYTARQVSGIFGCLEALVDQIVTYPSVPIGELNVVTPEETMLLLQQFMSNTADIPQYKKFSSLFEEQAMRTPERIAVICGNETITYRQLDEKANRWSSLLRGKGVSSNTIVAVMMERSIDLIASLLAISKAGGAYLPIDPDFPEDRIAFMLADSKACLLITEPHLGRKLDNVEQLLIRQTAVTGMEEDTNPNNTCGKPDDLAYLIYTSGSTGKPKGVMVSHKAIYHFFAGVTQRIPLQKFRSILSLTTISFDIFVLESLLPLACGLKIVLVSDEQRDHLYELSQLIELNDIDLMQTTPSRLNIMINDVHLVSALSKIKVLLVGGEAFPLPLLQKLKKTTNARIFNMYGPTEATVWCTMGELTENDGACIHIGSPLVNTRVYIVDNGNRLIPIGTPGNYALVGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D189</accession>
    <name>A0A398D189_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_01700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05261">
        <property type="protein sequence ID" value="RIE05261"/>
        <property type="gene ID" value="D3H35_01700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011623">
        <property type="entry name" value="7TMR_DISM_rcpt_extracell_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07695">
        <property type="entry name" value="7TMR-DISM_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017183475" description="Histidine kinase" evidence="10">
        <location>
            <begin position="37"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="488"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="436"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE05261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="718" mass="79544" checksum="ECFEC9B543FDC40C" modified="2018-12-05" version="1">MGCAAGDMTRRWMRFCLLAVLLTTAVVSSAVETAMANAGGERNADGQIPEATEGILDLTGHSLAGDGTVLLNGEWEFYWTRLLEPDDLPVYESRAVGMKFERVPSIWSAYREDGKALKNRGYATYRLTVKLDKADAGRTLALYMPSVATAYKLWINEDLAAASGKVGRSKEEMTARNVPDVIRFVPKGRELQFVIQVSNFVQRKGGLWEALRLGNEEQISYLRTKSILEEACILGCLVIMGLYHIGLYRFRKKDPSPLYFGAICLAVGLRMTVLGQTLLPYLLPDMTWQTAVRIEYMTAIIAFHLLIRYIHSQYPRECSPAVRWISLIACAGFGLLVTVAPPSIFTQFMLPYQLTVALPTVLYVLVVYVLAAIRRRDGSLLNGIGSGFFGLTVGGDVLYYNHLIPSGNFIPYGLLGFMFTQSLNLAGRLSREFGRSEQLAHELVQVNEELEDKVRDRTAELRASHDRLERINMELTGLEQSRKQLLTAISHELGTPLTSIQGYVKLMIDGVLPADDRESLQLIYNKTKILDRIIQDLFELSKLEAGQLQFRFGDIRIVPFFRGLAEGYTVQFKKSGLRYELELGEVDVEAVIAADPVRLEQVIAIFVTNAEKFTLPGGTIRTSLKPGAMPVTQAPAIRLSVADTGPGIAVNDLPFVFDRFYRGSPSAGKREDGAGLGLAIAKQIVEQHGGVIGVESRHGEGSTFYMLLPLRHAEEGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D281</accession>
    <name>A0A398D281_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_01455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05214">
        <property type="protein sequence ID" value="RIE05214"/>
        <property type="gene ID" value="D3H35_01455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="233" mass="26239" checksum="F7BEE1582974C0EB" modified="2018-12-05" version="1">MDNLLTIEHLSKSFMLHQLDKRIPAAIDVNLHLKEGEFVGITGKSGSGKSTILRCIYRTYLPNSGMIKFQSGTFGAVDLAAASERTIIELRKREIGYVSQFLSAMPRTTARELVRHAIEEMGNDADYAEEQTVAMLEHFELDRGLWDSYPATFSGGEKLRLNIARAMVKRPRLLLLDEPTASLDHSSKLKVKLLIEQLMKEGTTMLGIFHDLEFMQGLCNREYQMKDGQMGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CAT9</accession>
    <name>A0A398CAT9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UVR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_29955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00256">
        <property type="protein sequence ID" value="RIE00256"/>
        <property type="gene ID" value="D3H35_29955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025542">
        <property type="entry name" value="YacH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38430">
        <property type="entry name" value="PTHR38430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015034">
        <property type="entry name" value="YacH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UVR" evidence="2">
        <location>
            <begin position="137"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="176" mass="19500" checksum="52F864B12349457A" modified="2018-12-05" version="1">MQCQECGKRPATLHFTKIINGEKTELHICESCAREKGELIPGTQSGFSIHNLLSGLLDFDTSGTASVGAKAADAAQQPRCETCGMTYGQFGKVGRFGCSNCYKQFSERLDPLLKRVHGNTVHVGKVPKRAGGRVKAKREIDRLKKEMQGRIEREDFETAAQLRDKIRDLEKEMANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCH3</accession>
    <name>A0A398CCH3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_25870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000043">
        <property type="protein sequence ID" value="RIE00886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00886">
        <property type="protein sequence ID" value="RIE00886"/>
        <property type="gene ID" value="D3H35_25870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="269" mass="30376" checksum="D450A68BE053780C" modified="2018-12-05" version="1">MKKITMKDIAKEAKVSTATVSYILNSVESQSISEDTKEKVMKAAQKLNYIRNLNARTLKSGKSELIGILLPQTAGESYWTPYRYTKAIFHLGKYLNRHGYHLIVVHIDPDSPKLDILLEREVDGVFVLNAAAKTFYQISKRYGLGIPLIGIDTYNEDTLFHKLIPDFTAAIAKVAELLGRRPDFVVIDDYRDKKYVDTIKAATGLDQRDIHAYADERRLRKFLAGRSGQAGCVINEFCAIRFWLSRSAAASSPSVRAVFPSCCRHRCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCL4</accession>
    <name>A0A398CCL4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase/acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00936">
        <property type="protein sequence ID" value="RIE00936"/>
        <property type="gene ID" value="D3H35_25580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="118" mass="13547" checksum="2FC5F48651101BF9" modified="2018-12-05" version="1">MAQFSYVLLQREDGTLLFIEMPASHAYQLSALNLRLHKELSKLTADNVPQLPRAVAECRDLELLNESDTPIHGLKYVNELEQAFSAIRESAYPLVSLLTEIRALQAQLEQWYEEEDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD00</accession>
    <name>A0A398CD00_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_28050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00590">
        <property type="protein sequence ID" value="RIE00590"/>
        <property type="gene ID" value="D3H35_28050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="75"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="200" mass="21083" checksum="C031BB24915EB2DE" modified="2018-12-05" version="1" fragment="single">MFEIRTLAGQSEWGHANGAASASTFFHPRSLLELSDGRVVVSDSGNNMIRVVKAGQVSTLTGLYIGDDSAGLPLGSNKDGQSSEAGFNLPMGVAADGQGAIYVADSGNHSIRKIAKDGTVTTLAGNGNIGQTDGKGANAAFYSPSDVAVDAKATFMSRTRLTTLFENFRPTERYPSHGHVHSSDRIFSRSRRICGRLCDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE01</accession>
    <name>A0A398CE01_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxypeptidase regulatory-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00665">
        <property type="protein sequence ID" value="RIE00665"/>
        <property type="gene ID" value="D3H35_27270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="598" mass="63332" checksum="84384A136AD656A0" modified="2018-12-05" version="1">MADLTLTVQGSQVKLVWGDPPAGSGTVSALRILRKLGTGDWQTLATVADAAARSYTDLSAAPGKTYSYVIRGVDGNGQPFPYSVEKTVDIGGFAISSFNYTMPFYFRQHAGQGDKVKLTLLASAGAAAKAELAYLDVNGVNRTLQSALVEAAETGVYKGELAVPEAAAKLLSLKGYIEEDGQTAEAEALREPILVGGTVDVELTGALDLPNDSLLTIYSKSVHAYQSATLKGMRSVTLKGLPAADDYTLTLSGAGGIDLFDDVPVPPVRIVAGGHQLVSAEPLLPARVNVAIYNPSGTAPDVHVIVTDEEGHPLASGITALNGNLSFPAFKKMVGKKAIIRAAPKDPKFASLEQTVTLASGLNRLDLRLTLKTDATLTGTVTDKDGKPVKDATVQVWYQGNYYKAQSDTTGRYTLGVPAGNVYAQAIVAGAFASSAITVATVSGQTKTVDIRYTRQIPSIFEVKLYTETENGSWIGPYELDWREMVHFHITSSASLLGSSNPLLVDAAAGQSVKICANGIEGGYGKACTEVTIGDKLKYEAVLRLSYLNTKAVGQLAETPASVYLYRLDNGANKTYVESRTAYTGSLVLKLPGRERMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE88</accession>
    <name>A0A398CE88_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00755">
        <property type="protein sequence ID" value="RIE00755"/>
        <property type="gene ID" value="D3H35_26545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="67" mass="7334" checksum="ABDDAC838C4FE9E7" modified="2018-12-05" version="1">MDLVDVSNVSPALFVTGALFIMLIGSLLSLGVLRMFQQKKKPGIVMFVLAIVSFAVFVGVIDTWFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEB0</accession>
    <name>A0A398CEB0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_21625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01043">
        <property type="protein sequence ID" value="RIE01043"/>
        <property type="gene ID" value="D3H35_21625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="162"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="384" mass="43035" checksum="844D34880748F582" modified="2018-12-05" version="1">MDVSLQSNGADGRAGHPISVRRERHVRRFAERFLYMEEGAGVIIIDSEFRIVEMSEMVARLFGCRRSDWLNRPVEGWFGHLELDCPLFDRTLLEGCSFANRSFKWGRGEIAKSLMLDGDVLEPNGKGKGAYVLFRDASHLLVLEEQIRRSDRLKTIGQIAAGTAHEIRNPLTAIKGFMQLLQKSLTDKSMAKETEFIGIVMMELERVNDLVSEFLLLSKPKKVKLQSIRIGSIIQELLPMIRGEAMLHDVIVQYEEEESLPPIVVDKEQLKQVFLNLSKNAIEAMGNEGTLTIRERRRADRHGHIAVDIQDTGTGISPDMLERVFDPFFTTKPQGTGLGLSICQRIVHDMGGSIEAESEPSGTTFTVWLPFSHGSGGAVSRDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEC9</accession>
    <name>A0A398CEC9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Agmatinase</fullName>
            <ecNumber evidence="5">3.5.3.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">speB</name>
        <name evidence="5" type="ORF">D3H35_21790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01063">
        <property type="protein sequence ID" value="RIE01063"/>
        <property type="gene ID" value="D3H35_21790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="290" mass="31600" checksum="64AD1CFD5519AF1A" modified="2018-12-05" version="1">MRLPQAYSGNVFICSSDDYASSKAVIYGMPMDYTVSFRPGSRFGPGRIREASVGLEEYSPYLDRSIVDLEYFDAGDLLLPFGNAAKSLDIIAEFVRGVLDDGKIPVGLGGEHLVTWPVIQEVYKKYPDLAILHFDAHTDLREDYEGEPLSHSTPLRKAAELIGPSNVYQFGIRSGSKEDWTYAQQSGIHFHPFVVAEPLKSELPSLAGRPVYVTIDIDVLDPSAAPGTGTTEAGGITSGELLEAIHAIARSGVNVVGFDLVEVAPIYDPTEMTPIVASKMIREMLLGFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEV9</accession>
    <name>A0A398CEV9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family DNA-binding transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_28790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00412">
        <property type="protein sequence ID" value="RIE00412"/>
        <property type="gene ID" value="D3H35_28790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="354" mass="39866" checksum="ABC487F1F7BE10ED" modified="2018-12-05" version="1">MCSSTQCKERADLNVTIRQIAEKAGVSRGTVDRVLNGRQRVKPEVRERIEAIAQELNYVPNAAGKALAYNKKPALFGIVMPPKEIPFFDEIRAGIDIAADELKNLGIRLEYRYVDNKNSEEGAAAIKELVEAGANGIMFSVMDDERIRGCINEAAERGVPVITFNSDVEQSKRVCFVGQDLYKSGKVAAGLMERILPSRSKVLILSGNLNFQAHRARVKGFHEACEVNENKIEVVQIIEGFDRYDETRYKLDQALREHDDIAGIYLATGPIKAALDVLQEHGKAGKIKVVSNDLIPETEEGLRNRFIDFTIVQDPKQQGYRSLRILYDLIFIGKRPEQEYYYTDTHIYIPESLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF53</accession>
    <name>A0A398CF53_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_23565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01353">
        <property type="protein sequence ID" value="RIE01353"/>
        <property type="gene ID" value="D3H35_23565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005085">
        <property type="entry name" value="CBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM_fam20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03423">
        <property type="entry name" value="CBM_25"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01066">
        <property type="entry name" value="CBM_25"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="800"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="892"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="1080"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="1273"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="1466"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="3">
        <location>
            <begin position="1648"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1722"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1722"/>
            <end position="1749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1755" mass="189768" checksum="6C757F273DED77A0" modified="2018-12-05" version="1">MIALIISMQAGTTSAFAEISASHVYHNHMPNFWAYYDTSSYGSASVGSPIRYTYDGQVIELKKNPPAGYTFFNPSNGTALPHDDLVSYYTHHAKSGAYLYWPWQVAQSLRQSNPSAQVQVTMSAAVINNVNSFMTTNNVSGYNNPNWWQPWRNAYSTLFTPGGNRTLDTIHFSGHHSMGPLTGNDYLLKDLIYHNVTLAQPYFLGDAFTPSKGFFPTELGFSERIIPVLSKLGIEWSVIGNNHFSRTLTDYPLLNDPGKDTMVSPPNRADLQNTSSVGSWLAQPMFNEQQVVYNKFPFASTPHWVRYVDPATGSESKVVGIPVAQAESWEEGYEGSVRATALKPFEGLVAQKQFFVIAHDGDNSSGRAGSEDTWRNAANVTYSDSGVKGEGISEYLINNKPAANDVVHVQDGSWIDTRDSSSDPTWYHWHLPFGIWKGQFAAFNQATGLNLAPKKNLNGVDDGMTVSFEYGYHYLERNFALLQAAENYAKTAEQIWLDDHPNYWSPTSTADKKVTYSGNQLNPWMLSYPVKGDPNNDYKGGANPAELGWYFLLPAMDSGFGYYDENIDDGVKPTLSFNNSLYFTKPYVSQKLAKDKTGPSVWWPQRYPYNPGSSNVSKAEGWTLQYYDNTFGIYTYGYDVNGLSDIKLKVRTHTAKSADAKDNTFRVYDPAAMKAQGIANIDPSKVSSWVEYPMNKRDLKKDINGVAWQPSSTKMFQVVPAQEIGDLYYTYLNAYRDQLVDYYIEAVDNAGNVTKSDIQSVYVGAGKYKKDASGKIVEDVNGSIQGTYPFLVIDNEAPTAPSNVVAANTTDRSVSLTWSASTDNVGVTAYDVYRGGVKIGSTPTTSYTDTGLTATTSYSYTVKAKDAANNVSPASSALPVLTKEPDTIAPDAPTGLTAVEKSASTVKLSWTAATDNYGVEKYDVYRNGVKVGSTNQTVYTDVDLSPETEYSYSVKAFDAAGNPSALSVAITVKTEKGNIVTIFYKRGYPTPYIHYRPIGGTWTVSPGVVMPQSEAEGYNKITINVGTASGAEAVFNNGLNTWDNNGGKNYTFQQGVWTYDNGKITEGSPVVIVDTIAPSVPAGVQSTAKTHNSVTLAWNASSDNVGVTGYEIYRNGTKVGTSAQTSYTDSGLSAETAYTYTVKAYDAAGNKSDASSVLPVTTNAVPASNTATIYYKRGYSTPYIHYMPTGGAWTTAPGKAMTASTQYPGYNEITVDIGTATSLKADFNNGSGTWDNNGGKDYTFEQGTWTFESGVIKPGAPVGVIVDTIAPSVPAGVQSTAKTHNSVTLAWNASSDNVGVTGYEIYRNGTKVGTTAQTSYTDSGLSAETAYTYTVKAYDAAGNKSDASSVLPVTTSSIPASNTATIYYKRGYSTPYFHYMPTGGAWTTAPGKAMTASTQYPGYSEITVDIGTATSLKADFNNGSGTWDNNGGKDYTFQQGVWTFENGTIKAGTPVGVIIDNIAPSVPAGVQSTAKTHNSVTLAWNASTDNVGVTGYEIYRNDTKVGTSAQTSYTDSGLTAETAYTYTVKAYDAAGNKSDASSVLPVTTSAVPTSNTATIYYKRGYSTPYFHYMPAGGTWTTAPGKAMQSSTDYPGYSAITVDLGTATSMQAVFNNGSGTWDNNGGKNYTFQQGVWTYDNGTIKAGEPTVNPQTQGLTIQLSVPSTTTSSDSVYITGSFNNWDPAGSSYKMTRNSDGTYSIVLNVTSGTAIQFKFTRGTWASAEANSNGSDTANRSYTMTGSTQTLSQTVQKWKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFA6</accession>
    <name>A0A398CFA6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_27955</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00572">
        <property type="protein sequence ID" value="RIE00572"/>
        <property type="gene ID" value="D3H35_27955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="33"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="214"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="434"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="521"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE00572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="545" mass="59674" checksum="5548B77E9FCDC8E7" modified="2018-12-05" version="1">MSTFAEFGLEQGVLQAISEMGFEEATPIQAKAIPVALAGSDMIGQAQTGTGKTAAFGIPLLSKIAPSEDKIVALVMAPTRELAIQVAEEIEKLGRFKGLRSLAIYGGQDIGRQIRSLKRKPQIIIGTPGRLLDHINRKTIRLDDVRTVVLDEADEMLDMGFMDDIQSILSLVPEERQTLLFSATMPVNIQKLAQQFLRNPEHISVIPKQVSAPSIQQFYVEVQERMKFDGLCRLLDMEPPELAIIFGRTKRRVAELSEALMKRGYSADGLHGDLSQNQRDTVMRKFRDGSIDVLVATDVAARGLDVSGVTHVINFDMPQDPESYVHRIGRTGRAGKEGTSWTFVTPRETDHLHFIEKVTRHRISKKPLPTLSEAMEGKQKLMAERLLETVRDEEEVGAFKWVAMQLLEQYDSVQLLSAAMKLLTGDKKEVNVELTPEDPIRSKKRKFDGRGGSGGYGGRSGYSGGGQGGYRGGQGGGGYRGGQSGGGYRGGQGGQGGARKPYNREGSGYQGSGGAYRDGGSRGPRTERRDDSRGTRSQSEDFVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFP2</accession>
    <name>A0A398CFP2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="5">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="5">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">xseA</name>
        <name evidence="9" type="ORF">D3H35_26365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the XseA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00722">
        <property type="protein sequence ID" value="RIE00722"/>
        <property type="gene ID" value="D3H35_26365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_anti_2" evidence="8">
        <location>
            <begin position="7"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="125"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE00722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="453" mass="50329" checksum="69CF31F22250B7EB" modified="2018-12-05" version="1">MDQTRVLSIRDVNRYIKMKLEGDPKLQDIWLRGEISNFTRHSSGHMYFTLKDESGRLKSIMFASYNQRLPFAPKDGMKVLARGGVSVYERDGAYQFYVTAMQPDGIGSLFLAFEQLKKKLEGEGLFAEEAKRPIPRFPRAIGVITSPTGAAVRDILITLGRRQPSVPVILYPVSVQGTGAAPSIVRAIETMNRLAEADVLIVGRGGGSLEELWAFNEEAVARAIRGSTIPVISAVGHETDFTIADFVSDLRAATPTAAAELAVPHIAELKQGIVHMRQRMVKSLHLLVGKSRERWRHAARSPYFTQPRRTLLAQSERLDRLRDRLVFRSQAQAGRAKERLARLEGRLAASSPMEQAAFARKRAVSAERALRQSMGVAIKQSQSSFGSLVRQLDALSPLKVMGRGYSLVYNEQEKELIRSIGEVQPGDLIRVRLADGRLDCQVWGIQGEEKPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHA7</accession>
    <name>A0A398CHA7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01855">
        <property type="protein sequence ID" value="RIE01855"/>
        <property type="gene ID" value="D3H35_13785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="328" mass="35791" checksum="8ED41852D4559B63" modified="2018-12-05" version="1">MKGLILGAGNGSRLQPFSQLKPKVLLPVMNRPMIGYCIDKLAELELKEIGIVIQSRHEKLFRDEIGTGRRWGVSITYIFQDQLLGVADAVKQASSFIGDDSFLLLLGDNLIEQPLTALRDAVVRDGHNASILLGPVASPQEYGIAEVVNHRIVSLEEKPLHPKSNLAIVGAYAFGPTVFRAIDTLSPSVRGEFEITDAIGAMIRLGDSVSYCITTQKHLDMGRHERWLEANRWMLKLSQEARRKAAMAKYKGCTFIEPVAIAENCKLEGCIIGPNVTVGPNVELTQCLIANSIVLEGTHLTMSSHSSSIISPIATFSLRNGGGSDWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHR3</accession>
    <name>A0A398CHR3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfate transport system permease protein CysT</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysT</name>
        <name evidence="11" type="ORF">D3H35_19310</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02786">
        <property type="protein sequence ID" value="RIE02786"/>
        <property type="gene ID" value="D3H35_19310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011865">
        <property type="entry name" value="CysT_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005667">
        <property type="entry name" value="Sulph_transpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406">
        <property type="entry name" value="PTHR30406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406:SF8">
        <property type="entry name" value="PTHR30406:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00969">
        <property type="entry name" value="3a0106s02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02139">
        <property type="entry name" value="permease_CysT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="61"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE02786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="278" mass="30488" checksum="13AFA53BFA9B741E" modified="2018-12-05" version="1">MATLRKKDRVLPGFRLTLGFSVTYLSLIVLIPLAALVIKTTELSLSEFWDTITNARVVASYRVSLLTSLAAALVNLVFGLLLAWVLVRYKFPGKKIIDGLVDLPFALPTAVAGIALTTIYGPNGWVGSVLEPLGIKVAYTPLGITVALIFIGVPFVVRTVQPVLQDLESDMEEASVTLGAYRWRTFRKIILPDLIPPLLTGFALAFARGIGEYGSVVFISGNMPLKTEIAPLLIITKLEQYEYSQATAIALVLLIMSFVLLLLINILQRWSNRRLKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHS1</accession>
    <name>A0A398CHS1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_19365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02796">
        <property type="protein sequence ID" value="RIE02796"/>
        <property type="gene ID" value="D3H35_19365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="306" mass="34756" checksum="56261C6758F0FDA9" modified="2018-12-05" version="1">MLEDMRIFATVVEHTSLNKAAERLNLSQPALSRRISRLEAELGVELFRRIGKRLELTAAGQLTYEFALELRRFHGSYLQKLNAFKSNEAVAVTIGASLTTLQTTLPWLITAMTAKHPELEIKAITGKSHEIASLVKERKIDFGLVGSTVEDDPSITSVPLFADHLMLVLPRAHYILERTHWEMADLNELPMILFTPGTWYRTLTDDLFRRNGVKPDIRMEIDSFEAIVRLLAASRAGTLLPKSYIRPQLLEDNDLYVVNVRGLERTKRTISLIHGDLAWFAPSVRYLIEETTAMFTRVSREPKTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHU0</accession>
    <name>A0A398CHU0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">murA</name>
        <name evidence="9" type="ORF">D3H35_14690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02010">
        <property type="protein sequence ID" value="RIE02010"/>
        <property type="gene ID" value="D3H35_14690"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetylglucosamine binding" evidence="7">
        <location>
            <begin position="122"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="462" mass="48532" checksum="3DAFE76A1B49AE71" modified="2018-12-05" version="1">MSKIIVRGGRPLSGAVRVHGAKNSVLPILAAALLAEEGACVIHDVPALDDVTNILQVLAALGVHSQQSDDCVRLNADSLVSYDAPYELVRKMRASFLVMGPLLARLGKVRISLPGGCAIGTRPIDQHLKGFEAMGAEIGFGQGSIEASVSGKLRGAKIYLDVASVGATENIMMAASTADGTTVIENAAKEPEIVDLANFLNAMGAKVRGAGTGVIRIEGVERLKGVVHHVIPDRVEAGTYMIAAAITGGDVYVEGAIRDHLGPVVAKLEEMGAVVDCDENGIRVRTEKPLRAVDVKTLPYPGFPTDMQAQMMALLLRSEGTSIVTETVFENRFMHVDEMIKMGAEIKVDGRTAIITGGLNLSGAAVCATDLRAGAALICAGLVADGVTEVSGVHHIDRGYMDIVGKLRALGADILRAPSPEELLEEAEQRSLQPAVLLAGIAQPEREEAAAVRLLNVQPTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHU4</accession>
    <name>A0A398CHU4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenine nucleotide alpha hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01905">
        <property type="protein sequence ID" value="RIE01905"/>
        <property type="gene ID" value="D3H35_14080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="Alpha_ANH_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="PTHR12196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthami_syn_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Diphthami_syn_2" evidence="1">
        <location>
            <begin position="146"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="239" mass="26797" checksum="566506B92FAD794F" modified="2018-12-05" version="1">MKKKAALSWSGGKDSCMALERLERGGEYEVSCLLTTVPQEIGRTFGHGERLELIRAQADALGLPVEFISCSFESYTEDYVRSLLEAKAKYRLSAVAYGDLFLAEHREWGTGVAKKAELEAVYPLWMAPSAEGVAPGTAPAAWNEREATRQGLLRFVESGYRAIVIRVKDNALSADWLGRELDRSFYEDILRLSEVCPMGEGGEYHTFVYDGPLFQWPVVFERGETRQLETTKRLEIGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHU5</accession>
    <name>A0A398CHU5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_24870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01582">
        <property type="protein sequence ID" value="RIE01582"/>
        <property type="gene ID" value="D3H35_24870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="79" mass="9283" checksum="8CB2EEA4774260B2" modified="2018-12-05" version="1">MNRVDKIRYVLLYGKAPEAICYGYMEMNRDGNMIALYNRYGEEIDMYGGHEFVRVRTLGKFDDEDRDHFYSLLESDGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI62</accession>
    <name>A0A398CI62_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_12940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01712">
        <property type="protein sequence ID" value="RIE01712"/>
        <property type="gene ID" value="D3H35_12940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="117" mass="12534" checksum="8CD21BDF59D5DED1" modified="2018-12-05" version="1">MNIALWIAQGILGLIFIMAGMMKAFQYEKAKEGMPWVKEYSKGLVIFIGLSELLGGLGVILPYATGVAPSLTPIAAIALGIVMILAAGFHAKRKENQAIGMNILFLALAIFVAVGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI98</accession>
    <name>A0A398CI98_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_15605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02170">
        <property type="protein sequence ID" value="RIE02170"/>
        <property type="gene ID" value="D3H35_15605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003852">
        <property type="entry name" value="Sig_transdc_His_kinase_KdpD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02702">
        <property type="entry name" value="KdpD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="KdpD" evidence="4">
        <location>
            <begin position="20"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="KdpD" evidence="4">
        <location>
            <begin position="415"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="645"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="774" mass="87633" checksum="BF7A7E2E3EBA8423" modified="2018-12-05" version="1">MDSFRRKTPEELLYSIYRIQRGRLKVYIGAVSGSGKTYQMLNEGQKLKDRGIDVVACAVSTKRRPETVEQLAGLDRVPSIHWMQGDEEKKDLDVDALLKRNPEVVLVDGLAHRNRPGAERRTRLDDIRVLLGQGIGVIATVNAYELEGVTQLARKLTGIEAEATIPADTLELADEVRLIDVSPETILKRLEEGNLGGVKDPGFLKRGNVGKLRELALRLMAEDVNESLEKHREEQGLQGASGAAERILVSAQYHWNGSIYIRRGQQIARRLGGDLMVVTFVKPRRGKAPSKEAGAFKQSIAKLTEKIGAKFEEVPLPSRRKLPKELIRYATVNNVTCIVLGHSKQSRWQELWNGSVVNGILRRASNIDVFFIADRADHEGERVLPAKSRAPQPAPSEPYRRLSAQEIERKIEKMRRGKFKVYIGAAPGVGKTYRMLREGNDLLRKSIDAVIGYLETHGREETIAQVGSLPAIPRSVYDYRGTKLEEMDVPAIIARNPEVVLIDELAHTNVHGSKNKKRYEDVLEVLDAGISVIATLNVQHLESLNDAVEQIAGVRVRETVPDGILRLADEVELIDVTPKALQERLREGRIYAMNKVEQALDHFFKTGNLIALRELALREIADDVDERLEAWERNGSLRGPYGRREVIFVCVTTSGNAERLIRRGFRIAHRLKAEWRVLYVHSGRELRGELERRVRALREMTVRLGGKFEMERVESRNRVPDMLMLKANEYRSTQMVIGQSSRKWWEPLLRKSVVKTVLERGRHMDVLVIADFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIF7</accession>
    <name>A0A398CIF7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Omega-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Relaxing enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Swivelase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Untwisting enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D3H35_15515</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02155">
        <property type="protein sequence ID" value="RIE02155"/>
        <property type="gene ID" value="D3H35_15515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005738">
        <property type="entry name" value="TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01056">
        <property type="entry name" value="topB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="612"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE02155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="769" mass="85255" checksum="0AB64190A6754A9C" modified="2018-12-05" version="1">MKTLIIAEKPDMGRNIAAVIEPKAQNRRTYLEGDTYIISWAIGHLIGLAEPDLYDEKYKKWRFGDLPIIPDEFKLLPNPRTKDQLHVIKELAERCDTLVNACDAGREGQHIFSLIRRHLELNQPVKRLWISDLTAETIRKGFDQLKDDAEYDNLTRAARARSEADWLIGMNGSRAFTTKHNELLSVGRVQTPVLALIYDRHKQIEAFDSLKFYDVTAKFEQESTGYRGLWQGERMTDRKKAEAIEAKVKGKPGTIASYEIKDTKEYPWKLYDLTLLQRDANGKFGFSAKKTLDTAQTLYEKHKVISYPRTNSNYVTEQNIPEMHRALDALRGSDYDKFVQGANKKLVHTGNRNVCNATKVEDHHAILPTVKKPQGLSPDERKLYDLIVKRFLSHFYPPAEYKVHTVMTEVERETFKTTVKQLLSIGWKVLNEGDAGDKAKAKGKDADKEKEEEEEETDAPFSLDAAKPVQCVDVEVKEKETQPPKHYTEGTLLKAMESAGKQIEDEELRDAMKDSGLGTPATRAATIERLKQVGYVDMQGKQIRITPKGRKAVELIRGAGVALLTSPEMTGQWERRLNEISRGQASADTFMGNVKKFTRQIIEKVHYQRPAAKTDFAKPEPAAGKRTRAAAGSKSARSAVDAGEATQGGGSSRAGGAPKASAAVADKPSDGTIAACPRPGCGGRIFMGRKGYGCSNYKTGCGFVVWKESFGRTLTDAMVKSLVEKGKTGKLKFGAGAVTGAGGGQGGEPFEARILLSNPVTGGLALERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIG9</accession>
    <name>A0A398CIG9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02180">
        <property type="protein sequence ID" value="RIE02180"/>
        <property type="gene ID" value="D3H35_15675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="107" mass="11890" checksum="3C2C58927A0A7CE9" modified="2018-12-05" version="1">MLQMKGVAAMAIRYTREYDQILDDLSRAIATVPDFYDAFEMEAADWEELSDDERSVCVRTLADDIFYALGADPEIPVGTGTASYDASHGFIKVAATDQLVHVIPLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ42</accession>
    <name>A0A398CJ42_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HTH-type transcriptional regulator MntR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Manganese transport regulator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">mntR</name>
        <name evidence="12" type="ORF">D3H35_26510</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Central regulator of manganese homeostasis.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">DNA binding is strongly activated by Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the DtxR/MntR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00838">
        <property type="protein sequence ID" value="RIE00838"/>
        <property type="gene ID" value="D3H35_26510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00732">
        <property type="entry name" value="HTH_MntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022897">
        <property type="entry name" value="HTH_tscrpt_reg_MntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0010">Activator</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE00838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="140" mass="16569" checksum="51CA271E6637BDF0" modified="2018-12-05" version="1">MPTPSMEDYLERIYRLIDEKGYARVSDIAEGLEVHPSSVTKMIQKLDKDNYLIYEKYRGLVLTNKGKKVGKRLVDRHHLLESFLKLIGVQEENIYRDVEGIEHHLSWDSITCIETLIEYFERDPSRVEELRNVRTELETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJJ6</accession>
    <name>A0A398CJJ6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_16455</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02312">
        <property type="protein sequence ID" value="RIE02312"/>
        <property type="gene ID" value="D3H35_16455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02895">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01231">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HPt" evidence="11">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="326"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="10">
        <location>
            <begin position="533"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="7">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE02312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="669" mass="73880" checksum="2E6F9EE61BB28CF7" modified="2018-12-05" version="1">MYDMTAYRSLYLEELDDQLRLMEEEVLFLERDGESVEGIQRLFRAAHTLKGSSAAMGYERMKRLTHEMEHVLEKVRNRELTVTRVLATLFFRCVDRMKKLKEEIAEQSEEKAAIDDLVDSLRDKDGYSATTTGTRTFPDKFPLSDEEYRLARQRLDVGDRIYMLRTSLSQQCVMKTARSAVISGLLGECGIVLWSDAEYGDADEREESPALWLVASGISPDELAAEARSWVDVDEVELLECGAERLAAKDRRAKEELSTSEEPIAITTAGAKSRGQTIRVSVDRLDHMMNLVGELVIDQTRFIQVERALGQKFGTNEAVTELEQISDHLARVVGDLQESVMKVRMLPIDQLFSRFPRLVRDLCHSLGKEVEFLIEGKETELDRTLIEEIGDPLIHLIRNAIDHGVEDPADRRAAGKSECGKLTVSAYHEDNQVVIVVADDGSGIDGGRLLRKAVDTGVISAAEAEAYSERQAVDLIFHPGLSTASSVSDISGRGVGMDIVRAGIEKMNGIIDVETERGRGTRFKIRLPLTLAIITGLLTEVGDQTFILPMSNVSEIVRIDPKAIARVNGVPVLTLRGQVIPITWLHDQFGLSRQAGSRKQIPIVVIGRADKRMALAVDRLVGNQDVVIKSLGGYIGQVEGIAGATILGSGKVALILEIGGIMKMAGRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJJ9</accession>
    <name>A0A398CJJ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01349">
        <property type="protein sequence ID" value="RIE01349"/>
        <property type="gene ID" value="D3H35_23540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005883">
        <property type="entry name" value="PilM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11104">
        <property type="entry name" value="PilM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="358" mass="40641" checksum="7E55ACEB5882DBD1" modified="2018-12-05" version="1">MRIKQMFHQYFRRDCAGIEITDSCMKWVSLDNRRTETPVVHSYAIQPIEQGVIVDGVIVDKEAATRTLRALLARINNPTKRVHFVLPSQLVLTRILRLPDIPEPDLKKMVSFEIEHNLQLPFKHPYYDCIKLNGSANNRNQPSLKQLFSRKKPVQAGHIQIMGPAGAEAQNGMCDVLLAAAPYNRIEEYRNLFEECGLEPISFDIKSFSLFRLLQEDQSYDNEQTVMLADISANSADLVILQKGRIQISLNVPFQSSSQTDAAEDSFSQICAEFADEVDRLTKFYLYTLEHRGEDVATVYLTGDFGRMEDIREFLSRELPLEIRIVSNSRFSSQTPDFAPFFSALAVPLGLALRGSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJK3</accession>
    <name>A0A398CJK3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_17570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02500">
        <property type="protein sequence ID" value="RIE02500"/>
        <property type="gene ID" value="D3H35_17570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040751">
        <property type="entry name" value="SbsC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18316">
        <property type="entry name" value="S-l_SbsC_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017237940" evidence="1">
        <location>
            <begin position="29"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="S-l_SbsC_C" evidence="2">
        <location>
            <begin position="44"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="S-l_SbsC_C" evidence="2">
        <location>
            <begin position="142"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="S-l_SbsC_C" evidence="2">
        <location>
            <begin position="238"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="S-l_SbsC_C" evidence="2">
        <location>
            <begin position="338"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="635" mass="65665" checksum="6418E172B0CFBD88" modified="2018-12-05" version="1">MNFVKKSIIATAFSGAFAAIALIGSAFAATAPTPAEALSATISAGTDAGTTKVTAVPDSGDFLVYQLSKTQAKVPTQETTVPATAIYYVPSTDIKVDLKTAKYVDIYEIDGTTFKVKKFKELEIGTNYTANLAPAINKLVIAPGTAPTTIKATATLGKGNKLKVFPGNVPVTYPPLIGSSVEGGIVYTLGQNIPLDPTNDNYIAFVELDGSGKAVAFTEVKVDNAIVTASALKEPTIAAGSKAGTTKLTATLSKSGNALVYQLAAKKPTVLPTIGSSLPAGTFPYTSGNDIRGVDTVKNKFLNVYEITDKGKVASYQSFELKQADISVPAVTVTSSTYGKKAGSTIFVLKAAAGGTFQIALTDSPISVLPQVGDSAPSGTTAYKSGTDLIIGNSKYIDVYELNKQSKIVGFAEIAMADYGKITAPVLASTVQSSVYTAGSAALTVNSGNTVYYAINSKATNVLPAVGTPISTSGKVLVTSTTQDLVAFLGDVNKFVDVYELDGNGNLLSFASIKLIATMFAPAPINFTIAPGLSEGSTKLTVVPAKAGNIFKFEVRSVGDPVPTIVRGALPPGSVNLVNSGSEIGTLDPITKKFIDLYELAGGKIVGYKQIILTSADIKGAVPVETEEPTGLCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJN7</accession>
    <name>A0A398CJN7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02352">
        <property type="protein sequence ID" value="RIE02352"/>
        <property type="gene ID" value="D3H35_16695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="35"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="273" mass="30762" checksum="4ED7E1F9A1F69C15" modified="2018-12-05" version="1">MERPLNIRHEDLTLAATIHYPAADSKLPVGKLPLVIINHGFVGSRIGVDRLFVLTGRELADRGFLVIRFDFAGCGESEGVYGEHGLESMISQTRSVLDYALGLDIVDPLRITLLGHSLGGAAALLTATRDRRIKSLALWSPVGYPFNDIVRIVGRKTYDEAVTKGKSDYSGYTLKPDFFESLQQHQPFQEAQKFHGDVFIAHGTSDDVIPADYSFLLEKTFWLRGEGRCDKNIIFQADHTYTRGEHKQELIRSTADWLGGHDERQQNWHHWSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJP6</accession>
    <name>A0A398CJP6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactose/methyl galactoside import ATP-binding protein MglA</fullName>
            <ecNumber evidence="4">7.5.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_17780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + D-galactose(out) + H2O = ADP + D-galactose(in) + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:60156"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.5.2.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">The complex is composed of two ATP-binding proteins (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily. Galactose/methyl galactoside importer (TC 3.A.1.2.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.5.2.11" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02540">
        <property type="protein sequence ID" value="RIE02540"/>
        <property type="gene ID" value="D3H35_17780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043211">
        <property type="term" value="F:ABC-type carbohydrate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015862">
        <property type="entry name" value="ABC_transpr_MglA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43790:SF7">
        <property type="entry name" value="PTHR43790:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="15"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="265"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="511" mass="56881" checksum="D8D268565546D458" modified="2018-12-05" version="1">MVRSVKPVTKSTYLLEMDGIAKSFPGVKALDNVTLNVRPGTVHALMGENGAGKSTLMKCLFGIYTPDEGEIRMNGEKLVLANSKAALGSGIAMIHQELHPVPRRNVMENIWLGRFPLHNFGVLKFIDGKKMFRDTEKLFQELGMDIDPHEMVGRLSVSKVQSLEIAKAVSYNAKVIIMDEPTSSLTGNEVEQLFRIIDDLKKRGVSIIYISHKMEEILRISDDVTIMRDGRKIGTWPAAELTTDLIISKMVGRDLTERYPERTNVPGDSLLKVEGLTSPYRNSFKNVSFELRKGEILGVGGLVGAQRTELIEALFGLRSVESGQLSLRGQPIKIRKPIDAIRNKIALLTEERRVTGIFPVLSVLENTVIASQKNYEKFGFLNNRSRREVSEEGVRRLSTKTPSVNTQIRYLSGGNQQKVLLSRWLLTDPDILLLDEPTRGIDVGAKFEIYSIIADLAKQGKSIIMISSEMPELLGMSDRIMVMCEGRLTGIVDGKTATEEEIMRLAAQHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJW6</accession>
    <name>A0A398CJW6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pentapeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01148">
        <property type="protein sequence ID" value="RIE01148"/>
        <property type="gene ID" value="D3H35_22335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="294" mass="32315" checksum="890BA08236E6845E" modified="2018-12-05" version="1">MSDNPKHTEIYSEDSRHRLQADCESCFGLCCVALPFAASSDFAIDKSAGQPCPNLQSDFRCGIHNSLRQRGFRGCTVYDCFGAGQQVSQVTFGGRHWLQAPETAKPMIEVFPIMRQLHELLWYLTEALTLQAAHPIHDKLGWALDETRRLTRLDSDSLLELDVGAHRANVNTLLLQASELARDEARRRHKPPVKQRKNVGRGADLIGANLRGADLRSSSLRGAYLIAADLRGADLRAADLIGADFRDANLCGADLTGSIFLTQAQLNAAKGNADTKLPSSLVRPAHWSGSDKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKA6</accession>
    <name>A0A398CKA6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03143">
        <property type="protein sequence ID" value="RIE03143"/>
        <property type="gene ID" value="D3H35_15560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="241" mass="26362" checksum="08AF0059939A84BE" modified="2018-12-05" version="1">MEHSSGHEESGEGYAQVAFAFDGGKAKANEDSAVTIRISDSAGNPVKEFKENHEKLLHLIIVDHDLATFSHIHPDYKGDGTFTVTARFPSGGQYKLFADFVTADGTKETKSEWVNVEGAEAEHAPLAVDDKLVRQVDGQEVELTLSSVKAKEEAVLTFDIRDAATKQGIDDLQPYLGAVGHVVIISEDGSRYLHVHPVDEKAKGPKAEFMTTFPESGIYKIWGQFQRDGAVFTVPFVVKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKN1</accession>
    <name>A0A398CKN1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_29000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00447">
        <property type="protein sequence ID" value="RIE00447"/>
        <property type="gene ID" value="D3H35_29000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022627">
        <property type="entry name" value="DUF3502"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12010">
        <property type="entry name" value="DUF3502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017239539" evidence="2">
        <location>
            <begin position="34"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3502" evidence="3">
        <location>
            <begin position="381"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="514" mass="55230" checksum="4E52178051439863" modified="2018-12-05" version="1">MPRKSKTATVMLSIALILSLLLSACSKSNDSGSSSAPASGGSAASSDNGAGGSGNGKEIELKVAFLGLGNMKDVAAVQEEVSKITKAKINATVKLMPIDIGAWVQQVNLMLAGNEPLDLLVTSSFFNFSSQVAKGQLLPLDDLVAKYAPTIKDTMEPAIFNATKIGGKSYGVPSVRDTAADHGVAARKDLMDKYKLTFDNVKTYADLDPIFQTIKDNEPGVYPLVPRSQSNTIAAEIVRGHLDLLGDTPGVLLIDNQDLKVVNLYEQQMYKDALQLTRKWYKAGYIMPDAATTQESNNSLLKAGKGFAYFANMKPGFEAQETIANGHEMTGTRFVSPISTSDSSTGFMMSIPKNTTDPDRAAQLLNLLYTDKDIVNLIANGVEGKHYVDAGNGLIKAPEGGSNYVFNQWQVGNNALAKVWEGTSPDIWEQTKAFNKSSKFSKALGFSFDSSPVKTEVAAVANVNNQFKAGLEMGTIDPAKLDDFLSKLKAAGIDKIIAEKQKQLDAWAKENNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKP0</accession>
    <name>A0A398CKP0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03876">
        <property type="protein sequence ID" value="RIE03876"/>
        <property type="gene ID" value="D3H35_07860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="178" mass="19990" checksum="24FF92226A369B4D" modified="2018-12-05" version="1">MAQEDSGDKRLKEAVKLLRKGVDGDKKAAKDAYERFVEIRAANPSDALIEAYYGSALALTGRDAVKPLDRSDKAQQGLDALDRAVAMNPERAEIRLIRAGVCSRLPEDFFHRTKTAVEDFEWLLSRHRTDPGSLTDRQLIQVLLDLGAAYEKTDKPEEAKAAWKRLAQLDPKYKHLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKT0</accession>
    <name>A0A398CKT0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent dethiobiotin synthetase BioD</fullName>
            <ecNumber evidence="5">6.3.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DTB synthetase</fullName>
            <shortName evidence="5">DTBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Dethiobiotin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">bioD</name>
        <name evidence="6" type="ORF">D3H35_20500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the dethiobiotin synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.3" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02985">
        <property type="protein sequence ID" value="RIE02985"/>
        <property type="gene ID" value="D3H35_20500"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43210">
        <property type="entry name" value="PTHR43210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006755">
        <property type="entry name" value="DTB_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00347">
        <property type="entry name" value="bioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="120"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="213"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="251" mass="26474" checksum="EAF02FD878D791A0" modified="2018-12-05" version="1">MSRGVARKLRGLFVTGTDTNVGKTIVTAAITAVLRAEGRNVGIWKPVQSGALLGSGATDAERLLQWTGIRERPGAVSPYTFEAPLAPLLAAQKAGLSLTLQEVIAAGEPLVRRYESLLIEGAGGVAVPLTADALVADLIAELRIPALIVARSGLGTINHTLLTVSYLRQLKVPITGIILNDGECGAGKDDPSVASNAEQIERYSGIPVLGRFPRLPGGTDREALVNAVCQKIRIAPIREAIEMQSKEDERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKU1</accession>
    <name>A0A398CKU1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03926">
        <property type="protein sequence ID" value="RIE03926"/>
        <property type="gene ID" value="D3H35_08150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="65" mass="7585" checksum="B28EE892DB5D57ED" modified="2018-12-05" version="1">MVRKRKNVKPPEYLWAGSAQWSLSRFAQIKLQGIECALLLAIARRGLRFARPSKSYEMVSRYLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLC7</accession>
    <name>A0A398CLC7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_28960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00441">
        <property type="protein sequence ID" value="RIE00441"/>
        <property type="gene ID" value="D3H35_28960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017345052" evidence="2">
        <location>
            <begin position="31"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="180" mass="19461" checksum="969D4F1D1C27F344" modified="2018-12-05" version="1">MKSRIGWIVSVMLAITVFLAACSEKESNSANSAKNTNTNTAQSSQTPQQADKVTVNIGLQQSLDPMRVTKEKRFFEEEFAKLGAKVNWLEFQSGALYFEAMAAKRLDLGLAASAPVVVGQAANIDFKIIALTTDGLNDSSLLVSKNSSIKSLQDLKGKKVAVAREAAPGIFYIKCSMRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLD1</accession>
    <name>A0A398CLD1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_21025</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03070">
        <property type="protein sequence ID" value="RIE03070"/>
        <property type="gene ID" value="D3H35_21025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="4"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="385" mass="40143" checksum="359DF324F63CEFD2" modified="2018-12-05" version="1">MTSIYFDHAATSPMRAESLEAYLNTAGAGPSNPSSLHSFGRAARSRVTAARDAIASLLSCSPSELVFTGGGTESDNAALVGAANAQLARGRNGIVTTAVEHHALLHTCHNLQEQGFKLTVLPVDDTGRVSVEDAAAAIDDKTAVVSVMAGNNEVGTLQPIAEIGAVARDRGAVMHVDAVQALGYVQLDLANLPVDMMSLSAHKIGGPQGVGLLYIRKGTSFRPMLLGGSQERNRRAGTENVAGIAAFAAAAKLAEAERELRCRHAEELRQSLLTELEQAIGAESFVVNGPADSASRLPHVLNMSFPGIPSENMLMNLDLAGVAASGGSACTSGSLKPSHVLSAMNLSRDLVASAVRFSFGLGNTTEETKETAKIIATISARMRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLF1</accession>
    <name>A0A398CLF1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor 4</fullName>
            <shortName evidence="6">EF-4</shortName>
            <ecNumber evidence="6">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lepA</name>
        <name evidence="8" type="ORF">D3H35_06005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04176">
        <property type="protein sequence ID" value="RIE04176"/>
        <property type="gene ID" value="D3H35_06005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="9"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="21"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="605" mass="67688" checksum="5DFE8C27175B78C4" modified="2018-12-05" version="1">MTDHQANQSRIRNFCIIAHIDHGKSTLADRILEYTGAISSREMQDQILDSMDLERERGITIKLQAVRLQYKADDGETYTLHLIDTPGHVDFTYEVSRSLAACEGALLIVDAAQGIEAQTLANVYLALDNNLEILPVINKIDLPSAEPERVKQEVEDVIGLDTSEAVLASAKNGIGIKEILEQVVQKIPAPQGDRNKPLKALIFDSHYDAYKGVVCYIRVVDGTIKAGTKMKFMGTGASFDVVEVGTFRPRATVIDELGPGDVGFVVASIKNVKDTRVGDTITDAKNPTSEALAGYRRINPMVFCGLYPIESTDYNDLRDALEKLELNDASLRYEPETSQALGFGFRCGFLGLLHMEIIQERIEREFNIPLITTAPSVIYKVTLTNGETIDISNPADYPEAGKLERVEEPYVKASIIVPNDYVGAIMELCQGKRGEFIDMQYLDTNRVTLKYDIPLAEIVYDFFDQLKSSTKGYASFDYEVSGYRQSNLVKMDILLNSEKVDALSFIVHRDRAYNRGRVICEKLKDLIPRQMFEVPIQATIGQKVVSRETIKAMRKNVLAKCYGGDISRKRKLLDKQKEGKKRMKQVGNVEVPQEAFMAVLKIDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLT2</accession>
    <name>A0A398CLT2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lysophospholipid transporter LplT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lplT</name>
        <name evidence="3" type="ORF">D3H35_15670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02179">
        <property type="protein sequence ID" value="RIE02179"/>
        <property type="gene ID" value="D3H35_15670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="408" mass="43677" checksum="4426B1E73EA23EC2" modified="2018-12-05" version="1">MRGIEVKRKMGLTPLQAVVVTQFMSAFADNLNFFLIVGMVKRQGVANPDGMVTYIQMAVLLAYVVLAPLVGAFADKNAKAHVLLYGNALKAAGITLLLFGVSPVICFFLVGIGAVVYSPGKYGILSELTSNERELLRANAQVEGSTIFAILAGTVAGGLLASRSDLPAILVCLLVYLISLSMTFLIPARAGHADIRYGSAARSFFADLKTLFRNSRARFSLIGTGSFWLTAAVLRIALIAWLPVNLGITDTDQQSLIIGITALGVVASAVITPKLVPEGNLHRGYYYGIAMVATVMIASFTHMLWLTVSLLFLVGVFGGIFLIPLNTMLQEEGKRSVGPGKTIAVQNFVENSLTVAGLSIYLALTEMKVPINWSVVGIGIVLFLFIAFLATQIGQIRRAAAESIREAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLT9</accession>
    <name>A0A398CLT9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_13630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01828">
        <property type="protein sequence ID" value="RIE01828"/>
        <property type="gene ID" value="D3H35_13630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="247" mass="26200" checksum="370697D6B2A99A15" modified="2018-12-05" version="1">MRFKDKSVIVTGGASGIGESTVRLFAAEGAKVVIADFSDRGEQLAEELKSQGCEALFEKTDVTQEEQVKRMIASTVEAFGKVDVLFANAGIAKDGPAHELTSDAWRLTIDINLSGVFYCDKYAIEQMLTQGTGGTIVNCGSIHSHVGKGNVTAYAAAKGGVKLLTQTLAIDYATRGIRVNAVCPGYIDTPLIGGRTEAITRHLVDLHPMKRLGRPDEVAKTVLFLASDDASFVTGASLLVDGGYTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLW9</accession>
    <name>A0A398CLW9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00641">
        <property type="protein sequence ID" value="RIE00641"/>
        <property type="gene ID" value="D3H35_27130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="191" mass="21498" checksum="78F59703BFBFE391" modified="2018-12-05" version="1">MSDAGRIEMTFADLADVVWQEADVSIAGAYGEQELKDRLAEAAEKARAQARGRPSVVRFRLLGSGPLHEELLSESLADDWVRELREWLGSPEDREDWIWAESMKIRTSGTGDELADLPEEDGFIGELVRTGRSAAESPDESKRLLDEAMEALRHQPKIRQWVAGRTDADREELVSRALSRALALLIREDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM24</accession>
    <name>A0A398CM24_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADPH-dependent 7-cyano-7-deazaguanine reductase</fullName>
            <ecNumber evidence="1">1.7.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-cyano-7-carbaguanine reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NADPH-dependent nitrile oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">PreQ(0) reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">queF</name>
        <name evidence="2" type="ORF">D3H35_16210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-aminomethyl-7-carbaguanine + 2 NADP(+) = 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH</text>
            <dbReference type="Rhea" id="RHEA:13409"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="EC" id="1.7.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.13" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02269">
        <property type="protein sequence ID" value="RIE02269"/>
        <property type="gene ID" value="D3H35_16210"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046857">
        <property type="term" value="F:oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033739">
        <property type="term" value="F:preQ1 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00818">
        <property type="entry name" value="QueF_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029500">
        <property type="entry name" value="QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016856">
        <property type="entry name" value="QueF_type1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14489">
        <property type="entry name" value="QueF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03139">
        <property type="entry name" value="QueF-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="102"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimide intermediate" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="170" mass="19808" checksum="75B474F662F640BD" modified="2018-12-05" version="1">MSENASVGRSGQELKDITLLGNQGTKYPFQYSPEVLETFDNKHPSRDYFVKFNCPEFTSLCPMTGQPDFATIYISYVPDIRMVESKSLKLYLFSFRNHGDFHEDCMNIIMNDLIALMEPRYIEVWGKFTPRGGISIDPYCNWGRPGTKYEKMAEHRLLNHDIYPEKVDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM65</accession>
    <name>A0A398CM65_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03743">
        <property type="protein sequence ID" value="RIE03743"/>
        <property type="gene ID" value="D3H35_09300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="314" mass="36900" checksum="B69C7178E59C6749" modified="2018-12-05" version="1">MDFHIGSSRVIKQIVRSINSFQEDRIKSFQGGHLVKKNETFVDLMKVDYLNEISILEQIFVLEERFNIRFFTFNWPEGFRYESSFFAYIVFDNSKTKHRYEQNYFTIKIEQDALNKERHRVFFIPGTSNREVTIPEAFEILNKKSDVASAPLLNRELLQLGELTIGDLEALGRNIVDDESAIELSGSPGQQKSINAYLQLLKIKHDFILLKRIEESGHAFIEGKLAFEAYYIPRLKVAYREIEKNELTIRIINSDTKTIRIVHYHREYSLQQLFQFANLKTEVEDEFELLLTFSVYDLNVIALLAENVYESEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM76</accession>
    <name>A0A398CM76_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_11825</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03362">
        <property type="protein sequence ID" value="RIE03362"/>
        <property type="gene ID" value="D3H35_11825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="697"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="725"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="757"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="62"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="355"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="641"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="646"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="97"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="392"/>
            <end position="399"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="836" mass="92663" checksum="D42350F0F9CA887B" modified="2018-12-05" version="1">MMKSLSNLLLNVNLNDVEWLTNRIVAWEWRIGKREFFMAMERPGIGLALDGEQTNLQRPLVLSHVSVYAADELGTAIPRLEEVELSLHAGEWLYLVGVNGSGKSTVARLLAGLYMEGTTGSIERGFAGDRSSPVVLQYPEAQLFGETPLEELQFAMEWQGIPPEKMARRAGEKLAAAGLAGKENMTWDSLSGGEKQLAATAAAVVCEAPLIVFDEASSMLDELHREKVLRMAESLQRGGAAIVWVTQRLEELSPDKRVVAMEAGRVVYDGESRKFLFGESAGSPSPCASCGLRLPYLSHLAMELWDRGVWKGKPPMIAEEWSGALERLTFSADDRNLMKECPVNEPEKTGVSIKIPLREIASSRDGISVGGISGIAPGTLRLEPGTLTLMMGSNGAGKTTFLEKLAGLREPEGLRIAYGNEPLWTKRRWIGGNKLNARALRSYSYASQSPEHSLFARTVREELGYSLRPYKPDVRFEQQRMDDALSAVGWDRSWMERDPYQMSGGERRRTALASAFASPAGWLLLDEPTAGLDGAGHELIARQMLAMKGEGRGIVLVSHDSDWALPLADRVLIVHADRDRTIRACSRDELIAHPHWLEAAGMTIPAWLEIAHEAWRSGVAIDRLWQPRDLAASLTGLKGRQSDLAHEPCQSENDAPLSSNSSAEVETASRLLIRMDPRSLWLGYVLLSIGLFSQSDWLGLGIGAVVVLSILLIGHIPVWKWRWTLINFAYFAVFMSVIAGFSSGMGNWDGGAFKETLFPFTRTMLVLLLGLGMTAAITPLRLRRSLEQLLSRKGRTIPIAQRFILTLTLTIRFVPVLLKEWNRYRRLMLARGKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM95</accession>
    <name>A0A398CM95_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01928">
        <property type="protein sequence ID" value="RIE01928"/>
        <property type="gene ID" value="D3H35_14230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="232" mass="25363" checksum="FD17A19F1D7DD197" modified="2018-12-05" version="1">MSNLWIGLELAGSLLGSIIAWISGAKASRLLYSGSAERLHRKSRKLLVWTVLCTLPSLVSLFAILMSSVKSDTLFGADRILLHLPLIGVPLLALWLVTAPGAWRLWKQTKKLSGCPLPLEVRRHSAAPGLIVPFQALALNGVAVCYFSIVPPVPWSFTRATVSLLIFGLTALALWKLHDKRLERVIRSNAALASASGHTDFAPALREYRPRFNGAFAPYSASDTNIRGHHPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMI3</accession>
    <name>A0A398CMI3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03492">
        <property type="protein sequence ID" value="RIE03492"/>
        <property type="gene ID" value="D3H35_12655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="88" mass="10121" checksum="898E902A90CB1420" modified="2018-12-05" version="1">MKENGKEFKSDWQSGVADKLFINDPFSASRTVSVRGFGDFAARIDSIFVDLVYRDEENNYGQSQSVALSQAVNFFDWTFPVITRREDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CML5</accession>
    <name>A0A398CML5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03490">
        <property type="protein sequence ID" value="RIE03490"/>
        <property type="gene ID" value="D3H35_12645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="199" mass="21477" checksum="7C886A866C22F31B" modified="2018-12-05" version="1">MKSNFRIDGIVFIRRRHLVSGPEGAVRFLLRTGRACSERDPSGQAVLTLWLFGQNQSSRLQFGVQWTAEQSTLQALAAEIVRRYPERKLTAASIRLMPAQVDIDSVTLAIGDGSGTFADLQSVRSSGYPPFSALFNTALTSEQSGQATAALNGSPDRLTVTYRGQVQRSGQGAAQLAATADLSRWLPAGTSANYIRSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CML9</accession>
    <name>A0A398CML9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative pyruvate, phosphate dikinase regulatory protein</fullName>
            <shortName evidence="5">PPDK regulatory protein</shortName>
            <ecNumber evidence="5">2.7.11.32</ecNumber>
            <ecNumber evidence="5">2.7.4.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_26710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] = AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase]</text>
            <dbReference type="Rhea" id="RHEA:43692"/>
            <dbReference type="Rhea" id="RHEA-COMP:10650"/>
            <dbReference type="Rhea" id="RHEA-COMP:10651"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:83586"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate = diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]</text>
            <dbReference type="Rhea" id="RHEA:43696"/>
            <dbReference type="Rhea" id="RHEA-COMP:10650"/>
            <dbReference type="Rhea" id="RHEA-COMP:10651"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:83586"/>
            <dbReference type="EC" id="2.7.4.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.32" evidence="5"/>
    <dbReference type="EC" id="2.7.4.27" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00841">
        <property type="protein sequence ID" value="RIE00841"/>
        <property type="gene ID" value="D3H35_26710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016776">
        <property type="term" value="F:phosphotransferase activity, phosphate group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00921">
        <property type="entry name" value="PDRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005177">
        <property type="entry name" value="Kinase-pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026565">
        <property type="entry name" value="PPDK_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31756">
        <property type="entry name" value="PTHR31756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03618">
        <property type="entry name" value="Kinase-PPPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="149"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="264" mass="29792" checksum="03108F870B0A0201" modified="2018-12-05" version="1">MRDKTIFVCSDAIGETAEAVAKATLRQFATEQVKVKRYGNIKHEDEVKAIVREASDNGGFIAYTLVQPELRDTMREETVRLGVRAVDVMGPMMQAFIDTFNDSPKYKPGLLHEMDESYFRKIEAIEFAVKYDDGKDARGLLQAQVVLVGVSRTSKTPLSVFLAHKGIKTANYPITIEVKPPEELFKLKDRLVIGLTMQPERLLKIRLERLKALGLPSQAHYASLERIEKEIRFADEIMGRLSCPVIDVTERAIEETAGIIMSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMN0</accession>
    <name>A0A398CMN0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aamy domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03863">
        <property type="protein sequence ID" value="RIE03863"/>
        <property type="gene ID" value="D3H35_09955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="20"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="485" mass="55448" checksum="03FC3363849F7AFD" modified="2018-12-05" version="1">MSRMKGSRLDALRKAADAFRIYVRSDSQALAGQKTLKICELHIGEKIGRKTFDDYDQIAKKLSYLKSLGFNAIQIMPSFPFPSYSVYDYFNLDKTYGSERGLKNLVRTAKRLGLKVIIDMVLHGPLEKEPASWRMPPGEYEFDSPYLTDRTGWFSRHESGDYARTYTRSFDLANPELRRHISEAIAYYAGSVGIDGVRLDAQTWNFFPNWRPEGGRKPYESIYAGFRMMEEIRKEAKRHYPDLIFYTEGMGPLAAKYHEFRYNYDFHWIYPALSPVRDERGMSTMFWNPASENTLSWSDLAQWLEEQRTTVPPGLTIVHQTDSHDSHEWAAFWQGQFHREAFGPRLHRVHAALALFMDGGFMSFYGAELGNEAFYARLLPMKDLPLFSQGKCSYTDAWTNDTKVFCVAWTKGSEWAVVIGNLEDREKEVEVVFFPESDIALKARGSDPQLLDLAGDGKLSGAAEDGRIGLFMAPCGVLVLSNTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMN1</accession>
    <name>A0A398CMN1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_26115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000047">
        <property type="protein sequence ID" value="RIE00851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00851">
        <property type="protein sequence ID" value="RIE00851"/>
        <property type="gene ID" value="D3H35_26115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="187" mass="21599" checksum="D683ABA2246663A5" modified="2018-12-05" version="1">MQRKAYSTGIFFMAPITIIIFVFMVYPILQSVFYSLTDWTGIGGYHFVGFSNYKDIFSDEGFTDALKRTLFIGFSRRTRQLFRLLFAILLDQSLKTKSLLRALFYIPNVIPTVVAAFVWRYILDSNTGLLNKAMVELFGSGSSILWLDSPDYVVYTIIFITVWQMWGPILIIYLAALQGVPHEMRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMQ6</accession>
    <name>A0A398CMQ6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_17720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02529">
        <property type="protein sequence ID" value="RIE02529"/>
        <property type="gene ID" value="D3H35_17720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="230" mass="25393" checksum="E8977F620D78012C" modified="2018-12-05" version="1">MTEASQNIIRASGVIRTFGRGSGAVTVLKGIDLSIPSGKLIAFKGRSGSGKTTLINLLGALDRPTEGTIEFDGRDMTGLSDRERDQIRRTRMGLIFQSFALIPLMSAYENVEFVLRIADYPAKDRQRAAEAALDQVGLKPRMHHRPFEMSGGEQQRTAIARAIAHKPKLIMADEPTAELDSRTGLHIIKIFRDLVQQQGISVVLTTHDPAIMEIVDQVYELEDGQIVAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMR8</accession>
    <name>A0A398CMR8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01197">
        <property type="protein sequence ID" value="RIE01197"/>
        <property type="gene ID" value="D3H35_22635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029441">
        <property type="entry name" value="Cass2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025868">
        <property type="entry name" value="Zn_ribbon_dom_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14526">
        <property type="entry name" value="Cass2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12674">
        <property type="entry name" value="Zn_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AraC_E_bind" evidence="1">
        <location>
            <begin position="109"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="270" mass="30278" checksum="D55E503C363BD409" modified="2018-12-05" version="1">MTTATLFCQSCGMPVASEEVHGTEHDGAKTDKYCTYCYQDGAFVQPDLTLKGMIEASIPYMVEEGMDEQHARELLQHQLPGLERWRGQQREADKDNDSGAVAAFSQPIVEPLVKQLDAFSIAGLAGVTANEAERGPDAKIAKLWERFWQQDQLQSLFSSGDEPHVSYGCYSNYSDGVNGSYQITVGCRIGSEQDVPEEWTRVDLPASRYAIFTSRRGPVVEVVVELWQHIWEWAETGSYKRTFTGDFERYDVRSANPNETVVEIYIAIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN22</accession>
    <name>A0A398CN22_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03875">
        <property type="protein sequence ID" value="RIE03875"/>
        <property type="gene ID" value="D3H35_07855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="324" mass="35280" checksum="4F754C22E40E93B5" modified="2018-12-05" version="1">MDDEGTEPRNRPIEADSSKGERDSIEPPAAEILTPEQQEDAREADSPKDDGELEWAQFIRKELIKKHGTSADDWQPLTNGRGASDVGIPLAPAVIPASPRAIPAAPTGAESKVLKRKAEKKPSEPVKPAEKTAPEPAKERKIRKELLEPTRSERNEPRRFERGAREWHKSPPIAEKKLPEPTHVAGNAIHTPAHVEAIEPPNPKPEAAIAIADFAPTDAIVAVASEPMLPAIVDSVIPAAPIPLSEPSNAAAAAVAEGRRPRSRSARKPVRTRKRVPVNRTKAASGTRQKAVFKKKTKRSPKAAARRSAVRIRTKPAARKRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNI4</accession>
    <name>A0A398CNI4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01141">
        <property type="protein sequence ID" value="RIE01141"/>
        <property type="gene ID" value="D3H35_22290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017301323" evidence="1">
        <location>
            <begin position="33"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="257" mass="29253" checksum="FC5136BE865D66DC" modified="2018-12-05" version="1">MKWNRFVGASLIALLIFATACSGDGTDKTASAELPLIKETDHGLFYSPDLPENVNRVITILSEAFESNYSRIAKLFDYELSDKTSIYVYTDKSEFQTMMGRATEGSYVASEKIIKVYTPANLDDPETREEYTDQIVHEFVHAVIQQINPSVGRVKWLDEGAAYYASNQLGKELQRRAVFFDLPTLEQLKSPDYFDEAGSAAYFYCGTFVQYMADTYGADALNRIVRNPKQIERILNNSFEKLYEQWKIQMSKPPSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP30</accession>
    <name>A0A398CP30_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_08345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03960">
        <property type="protein sequence ID" value="RIE03960"/>
        <property type="gene ID" value="D3H35_08345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="25"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="113"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="180" mass="20874" checksum="C3E650E90AB9F333" modified="2018-12-05" version="1">MPEPPLDTSMILEARSGDKEAFGLLIRKLSHEMYRLAKAILVNDEDCADAMQETIVRAYGGITKLREPLFFRTWLFRILIRECQQTLRRNKKMLPQSSLPEKGVIQAIPDYDLHSAVDRLEESLRIAVKLHYFAELPLSRIGELMAISEGTVKSRLFRARKQLAEQLRSPDERKMEYELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPR8</accession>
    <name>A0A398CPR8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ger(X)C family spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_06045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKC lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04180">
        <property type="protein sequence ID" value="RIE04180"/>
        <property type="gene ID" value="D3H35_06045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008844">
        <property type="entry name" value="Spore_GerAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038501">
        <property type="entry name" value="Spore_GerAC_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35789">
        <property type="entry name" value="PTHR35789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05504">
        <property type="entry name" value="Spore_GerAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02887">
        <property type="entry name" value="spore_ger_x_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="402" mass="44808" checksum="BDC137947F2DEFC8" modified="2018-12-05" version="1">MKIALRVILVSLLALITGTGCWDRRELNELGIQLGAAIDKSSEGYELSVQVVDPGQVASAKGSGGINRAPVTMYKASAPSILEAYRKLTQTSPRKIYNSHLRVLVIGEELARDGIAKALEMQSRGSESRTDFFIMIARKTSAENVLKIITPLEKIPANKMYYSLDASARSWAPTTTFTLDKFINQLVTDGLNPVLTGIDIVGSQHEGESNRNVQNIDPAARLVFSGLAVFRRDKLVGWLNEEESRGYNIIMNNLYSTAGPVTCPNGGNVIVEILRSHTKMTGKMVGDKPVIDLTFTAEANVGEIACDIDITDPQSLRQLEKTAAKLTVKALDETIDSVKQKYNTDIFGFGDAIHRYHPRQWKKVKDKWANEMFQRTEVRFHIHFYIRRTSTKGNSFIEDLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPW2</accession>
    <name>A0A398CPW2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uracil/xanthine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_03575</name>
        <name evidence="6" type="ORF">D3H35_13860</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000022">
        <property type="protein sequence ID" value="RIE04918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01867">
        <property type="protein sequence ID" value="RIE01867"/>
        <property type="gene ID" value="D3H35_13860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04918">
        <property type="protein sequence ID" value="RIE04918"/>
        <property type="gene ID" value="D3H35_03575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="438" mass="46739" checksum="5EFEA0A4F758B06B" modified="2018-12-05" version="1">MKPDLSPKILFAGIQWMFFILTNTVVVPLTLGQAFHLQPEQIAASVQMSFVLTGAACVLQAWIGHRYALMEGPSGVWWGLTLSLAATAGAGSGGPGLAAVGGGLAAGYLLSALLMVALGALGFVSVLTKVFNPIVISVFLFLLTVQLEMNFFSGMLAVDGEGRLNPSIAALSAATALFVGLLYLKGRGWISNFALLLGMIVGWIVFEWLFPGYSSRHAPPPSHPSAEAAFAWFPWGAPRIEIGIMITSFVVGLVNMSNTVTALSSAEKLYKRKTTNAQYRRSFVLTGAFSALSPAFGLLPFGTFASSLGLLESTKILNRSAMVIGSGLFFLFGLVPPLGDFLSEMPLSIGSAVLFVAYLQMFGTAVRTIRGQAFDSKTIYRLALPILLGICIMNVPAEAFSVLPVYIRPLLGSGLIVGIVVSVLLETTVNWQREERED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ26</accession>
    <name>A0A398CQ26_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4190 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_21925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01084">
        <property type="protein sequence ID" value="RIE01084"/>
        <property type="gene ID" value="D3H35_21925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025241">
        <property type="entry name" value="DUF4190"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13828">
        <property type="entry name" value="DUF4190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4190" evidence="3">
        <location>
            <begin position="52"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="146" mass="15668" checksum="E87C920BC1F3471A" modified="2018-12-05" version="1">MGRRNHLGGSEVDQFSNESQPHNDSQPINESQQYAFSPPPNPYQPPKTNGKSIAGMVLGICSIAIPYIGFIIGIIAIIFSSLSLKEIKRNGDQGRGMAVAGLVCGIIGTALYAIIILAIVLVIAFNPDIGNNYDFSNNSNNIEQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQA4</accession>
    <name>A0A398CQA4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04693">
        <property type="protein sequence ID" value="RIE04693"/>
        <property type="gene ID" value="D3H35_04190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017184860" evidence="1">
        <location>
            <begin position="30"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="310" mass="34818" checksum="C7A65641140124D8" modified="2018-12-05" version="1">MKQHFLAAIALFAGIATGCVNHPNNSSSAATSPVSIQDWKQVLKSEQNHSIEGNVKIINQFPVHSLGTTRNIWIYLPPGYEESDSRYPVLYMHDGQNLFDKATSYAGEWGIDETMERLSADNEAFKMIVVGVENGPRRMYDYTPYPNSDGLGGDGAKYVAFLTDELKPFIDKSFRTKPNSPDTYISGSSLGGYISVYAGLERPDIFGNVLAFSNVFQIGQKAFFGYIGQLDRTLDSSRFYLDIGTIEDQQFSYSVSDNRKVLEMLQAKGVSEDRLKLYIDPVGDHNESAWNRRFPDALKWILEREVGDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQG1</accession>
    <name>A0A398CQG1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DAK2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_07390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04400">
        <property type="protein sequence ID" value="RIE04400"/>
        <property type="gene ID" value="D3H35_07390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019986">
        <property type="entry name" value="DAK2_dom-cont_prot_YloV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033470">
        <property type="entry name" value="UPF_DhaK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13684">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01121">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03599">
        <property type="entry name" value="YloV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DhaL" evidence="2">
        <location>
            <begin position="9"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="614" mass="65585" checksum="A9A4737ACA44B67B" modified="2018-12-05" version="1">MSKRFLNGNEWAAMVFAGAERLSANAERVNALNVFPVPDGDTGTNMNLTMSAGSAELTNRPSEEVGKAAEALSKGLLMGARGNSGVILSQLFRGFARAVAGQRELTVPLFATALQQGVDTAYKAVVKPVEGTILTVAREAARHGTAASRRTDDLVEWMTEVLDKASETLARTQEMLPVLKQVGVVDSGGQGLVYIYEGFVAYLSGSAEFPAAGSPSSSASLPIAPEPPARTATVHAVRDPRSSAQAKLETESIEFPYDMEFFIRKFPGAAFPEQKFRQALERDGDSIILIDDGDIVKVHVHSRRPGDVLNYALAHGDLTDLHILNMQEQHRELLRPYGETPAAASQQKATAIMPEMYEALGLEAASGISVAGYSASGVVASPESEPNPDVHELADYGVVAVSVGEGNAELFRSLGVDVVLSGGQSMNPSTEDLIGAVQSLAAQRIFLLPNNPNIVLAAKQAAELADRPVTVLPTRTIPQGMAAMLAFEENDPETINIERMTKASERVLTGQITIAVRDTVMDGVDIREGQYIGILDKTIINAASTKEEASRQLLAKMLESGSGGEIVTILKGEDADGEEAELLATWIEENYPDAEVEVHDGGQPLYPFLFAVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQJ4</accession>
    <name>A0A398CQJ4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="7">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">mnmA</name>
        <name evidence="8" type="ORF">D3H35_21015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03068">
        <property type="protein sequence ID" value="RIE03068"/>
        <property type="gene ID" value="D3H35_21015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Interaction with target base in tRNA" evidence="7">
        <location>
            <begin position="103"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="154"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="315"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="377" mass="41716" checksum="7319D2C7AAF39A66" modified="2018-12-05" version="1">MDDIRFEDPSSVRVVVGMSGGVDSSVTALLLKRQGFDVIGVFMKNWDDTDENGVCTAEEDAEDVRRVCDQIGIPYYTVNFEAEYRDKVFEYFLEEYRRGRTPNPDVMCNREIKFGDFLQKAMDLGADVIATGHYARVERVDGQYRLLRGVDGNKDQTYFLHALNQSQLSRAMFPIGHLPKPEVRRIAEEAGLATAKKKDSTGVCFIGERNFKEFLSQYLPAKPGNMVDILTGDVKGRHDGLMYYTLGQRQGLGIGGSGNGEPWFVADKDLASNVLYVVQGERHHSLYSVGLTATGINWISPDALSGPLRCTAKFRYRQPDQGVTLTLTPEGDLNVEFDAPQKAITPGQAVVFYDGDVCLGGGTIDKVRKLEPSAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQK2</accession>
    <name>A0A398CQK2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_12875</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01701">
        <property type="protein sequence ID" value="RIE01701"/>
        <property type="gene ID" value="D3H35_12875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="53"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="113"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE01701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="333" mass="37401" checksum="18537CCD52DCFE9E" modified="2018-12-05" version="1">MVLGLPFKINGKPFALFITPEFGELGSFIGSWLRNQLLIVLLFGSLFIVVSARYIVRPLQHLTAATRKMAKGDFSFRLTTKRKDEIGQLTTSFNRMAHELGMLENSRRQFVSDVSHEIQSPLTSIKGFTHALIHKKMDEASRVRLLGIIEDETNRLSRLSEDLLQLSSLEYEHLQLNVSNYRLDEQIRNVIIASEPQWSFKNLAIELESAEVLIMADQGKLNQLWTNLIGNAIKFTEERGSVRVTIREDNHGIKVLITDSGQGIPEEEIGNIFKPFYKVDKSRDRAISGNGIGLSIVKRIVDLHQGDIQVTSRVGEGTTISVHLPPLSTAAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQP1</accession>
    <name>A0A398CQP1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00460</name>
        <name evidence="3" type="ORF">D3H35_00490</name>
        <name evidence="1" type="ORF">D3H35_13125</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000005">
        <property type="protein sequence ID" value="RIE05438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000005">
        <property type="protein sequence ID" value="RIE05444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01741">
        <property type="protein sequence ID" value="RIE01741"/>
        <property type="gene ID" value="D3H35_13125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05438">
        <property type="protein sequence ID" value="RIE05438"/>
        <property type="gene ID" value="D3H35_00460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05444">
        <property type="protein sequence ID" value="RIE05444"/>
        <property type="gene ID" value="D3H35_00490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="487" mass="53898" checksum="65701D10EC84E6EA" modified="2018-12-05" version="1">MGNYSQRLLEGAETQHLVNFRQGLTTLFLGGNARMNNRKWLKVLLLVLVCCLCVSLAACQSKENTNNEASGTSGKQPSEKTTIKMWTFLDPNGTSAREVALKQIITNFERDNPNVKVAVEPQVWDTLGTKFLAANQTGNAPDVIWTSMDDFGTALKQNALVDFESLFLNSWTPEDIKDIDDAYWAFGNKDGKHYQVTLSRNYIGILYREDLLAEKGIKVPFKTWDELIDAAVKLTEKDAATGIQRYGFGQAFSPESPDPQVFPPSLIQSQGDMFTEGGKANWSTDAGVTAMNRQLDMVTKYKVTPDSAISSSVEDVYNEFKAGRYAMMIGAGVRIPTLQKESTFDGSKIQMTYFPSEDGSTFSPSVINGWNVGVWSGSKNKEAAGKFVEHMINAESDEIWMTVGGQVPVRKSTVQKNADFLSKPDKTYLSVMAEGFAKYGYAQPWEFPVSGWRADLNKIAQDILVKGKDVKAALQAAEKEFNERAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQP2</accession>
    <name>A0A398CQP2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cysteine desulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_06305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04480">
        <property type="protein sequence ID" value="RIE04480"/>
        <property type="gene ID" value="D3H35_06305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="3"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="391" mass="42238" checksum="97923B7CD40DA3A1" modified="2018-12-05" version="1">MYYYDHCASAPIHETVLRTVTELMELHYANASSLHRSGAEAMKLVERARAGVAAVMGAKPGEVIFTSGGTEGNNLAIKGTVAKSSKSRKHVISSAIEHASVYQCLRQLEEQGIIEVSWLPVDCYGRVSVQDVEAAISPDTILVSVMHVNNETGTVQPIREIGALLAGYPQIRFHVDGVQAIGKTALNWNGWGIDLYTGSAHKFRGPKGVGFLLVREGIALSPLLAGGSQEQGVRGGTYNVPAIVGMAQALRLASESMERRRETMYGLRSRLLGLVRNIPELVVNGFGAEAHQETQDEAAPHIVNVSYPGMRPEVLVHMLEKQGILISTQSACSSKSLKPSRVLLAMGHKAERASGSIRVSFGDEHTEADIDVLGERLAMTVRKLKPLEGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQP6</accession>
    <name>A0A398CQP6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04875">
        <property type="protein sequence ID" value="RIE04875"/>
        <property type="gene ID" value="D3H35_05270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="150" mass="16708" checksum="03A04AD4250B3DF3" modified="2018-12-05" version="1">MKENKLLRMDNVGIVVDSLDDAISFFEEIGLKLEGRATVEGEWAGRVTGLGSQCVEIAMMVTPDGHSRLELSRFLTPHTISDHRTAPVNSLGYLRVMFTVQDIDEMVSRLTKYGAQLVGEVVQYEDSYRLCYIRGIEGLLIGLAEQLGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQU2</accession>
    <name>A0A398CQU2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_05395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04530">
        <property type="protein sequence ID" value="RIE04530"/>
        <property type="gene ID" value="D3H35_05395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="144" mass="15480" checksum="7E7F5560B2AB3AEC" modified="2018-12-05" version="1">MSKQAVIKLANGNEVVVELFDKDAPNTVANFEKLANTGFYDNLSFHRVIPGFVAQGGCPNGNGTGGPGYEIDCEINPNKHERGALAMAHRGKNTGGSQFYIVYAPQPHLDGVHTVFGKVVSGMEHVDQFKGGDKFESIKVSETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQU6</accession>
    <name>A0A398CQU6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_03545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000022">
        <property type="protein sequence ID" value="RIE04913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04913">
        <property type="protein sequence ID" value="RIE04913"/>
        <property type="gene ID" value="D3H35_03545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="97"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="300" mass="33626" checksum="0843DF2991C4A79B" modified="2018-12-05" version="1">MARSPWVYDPGSPDQRHASSRLRRTNPTAKSLLTFTLRQPLGLKPKQSNLYEEVFFIMPDHAKIYLEEAEKYARLIASQPPLDGVIEEIRPFEGLDIVDIGAGTGRLSAVLAPRAKSLVALDASQAMLNETARQLSEAKLSNWRTEVADHRRLPLEDGCADLVVAGWSVCYLASADAPDWEDNLRIVMSELKRIVRSKGTIILFETMGTGVETPAPPDFLLPYYAQLANLYGFAHRWIRTDYLFESHIPWRKRSGSIRMSHQTPPHSGTRRSSSRATRSPSSSPKKKRVISSASLVDSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQX7</accession>
    <name>A0A398CQX7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03198">
        <property type="protein sequence ID" value="RIE03198"/>
        <property type="gene ID" value="D3H35_19145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="248" mass="27201" checksum="14B80FFAF1C20578" modified="2018-12-05" version="1">MTQYRLLAIDLDGTLLNEAGEISAMNHEWVKKATDAGITVCVSTGRGFKSALPIAEQLGLQTPMITVNGGEIWSKPHTLHQRTLLDSDKVAKLHALAKRYPETWFWAYSIEDIYNKERWIDNDPEAHEWLKFGYYTEDKNALDGILAEIRTWDGLELSNSSPFNIEVNPSGVSKATAVEEVCRLLGIELSQAVAVGDSLNDIAAIRACGLGVAMGNAQDEVKASADIVTSSNLEDGVAHLIQNYLLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRE9</accession>
    <name>A0A398CRE9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_03015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05112">
        <property type="protein sequence ID" value="RIE05112"/>
        <property type="gene ID" value="D3H35_03015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="198"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="300" mass="33887" checksum="A0DBA544F6C71054" modified="2018-12-05" version="1">MSNERSEPTEAYEWDELTNRILAEYPVQCVSRTGPLGQKTLHAHEGFELYLCVSGSGFYMVGDRLFPLHAGTLTVIPPHAIHRAYSGSLSSFRRFVLSVDTSYLKLLNDACPTTEPDLLQLLAGERSTAGSHYFLPMPQFGRVQSLLEELEQTLLEKSFLYELTILRIMSEVVFLVVNLEEAAGNDSQPRSADELLVGDVLAYLVAHCQEEIRIEDLLWRFPVSRSRLFGLFKETTGTTIKQFLTEYRLNKAKRLLADTALSITEVASRAGFGDLSHFYGTFRKATGVTPRSYRFQKTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRG5</accession>
    <name>A0A398CRG5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05155">
        <property type="protein sequence ID" value="RIE05155"/>
        <property type="gene ID" value="D3H35_01940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="251" mass="27747" checksum="3203DA101C7F34E9" modified="2018-12-05" version="1">MDVWNEAEDFVFRVPNVLALKAIRKEHRAPGTVVWVDGYHEAGDPGGKLVRWSEHSVAADNGGTVHAPEDGGGPGRWLLVHEGIGNFRAFGIFGAENAADDALDAMVNDDTIYRIEAGSDLKLVRRHRFERSGIELDFNGFAVYTDGIEEAASNDPFSAVLLFKGSEAGIVQTLALTERLEEMQELFEVADSSVFQIGDWWIAQSNRLSGSAERELDKLVRVTEIADATHVRFDYKNGWALSAGERLLTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRZ9</accession>
    <name>A0A398CRZ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02141">
        <property type="protein sequence ID" value="RIE02141"/>
        <property type="gene ID" value="D3H35_15410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="78" mass="9027" checksum="AD92ACF2C77CEE0A" modified="2018-12-05" version="1">METTAQQVAEWMVEEIRFRGILHQADAIAHVRTNFGEQFVFVNESGNASLDKEVKKAFRKLHGGKVAWDRDGFFWGWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS02</accession>
    <name>A0A398CS02_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Threonine-phosphate decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.81</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">L-threonine-O-3-phosphate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_08560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + O-phospho-L-threonine = (R)-1-aminopropan-2-yl phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:11492"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58563"/>
            <dbReference type="ChEBI" id="CHEBI:58675"/>
            <dbReference type="EC" id="4.1.1.81"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.81" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03999">
        <property type="protein sequence ID" value="RIE03999"/>
        <property type="gene ID" value="D3H35_08560"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005860">
        <property type="entry name" value="CobD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01140">
        <property type="entry name" value="L_thr_O3P_dcar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="10">
        <location>
            <begin position="39"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE03999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="354" mass="40131" checksum="AABC3F09B6FE3226" modified="2018-12-05" version="1">MKLERYGHGGDLATATEAYGLPQESWLDYSSNMNPWGPPEIVGELMKEHWRDVAKYPDPAVRRLRAKLSETYRIPAESILVGNGAAELIDLVVRVFKPEETVLARPSFSEYEEAVLKAGGRTRSVLLREERMFELANAREFASGAVFLGHPNNPTGRLIPAHVLDELREAGSRMIIDEAFMDFVPDEEELSYIRRASESEQIQVIRSMTKFYAIPGIRLGFMVAHPDLIRRLAEAQTAWSVNFLAQLVGEAVLDERAYAERTKTWLLEERPWLSGELRSLGLVVYPSDVNFLLVSLAGLEGWNVGRLQRAMAGRGILIRDASLFEGLNDSYFRIAIRLRPDNERLIKELKECLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS13</accession>
    <name>A0A398CS13_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-methyl-L-tryptophan oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_08625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04009">
        <property type="protein sequence ID" value="RIE04009"/>
        <property type="gene ID" value="D3H35_08625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PTHR10961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="2">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="365" mass="40236" checksum="C5680350B27D11F4" modified="2018-12-05" version="1">MGMSAGYELARRGFKTLLIDAFDPPHPNGSHHGEPRLIRHAYHGGEAYVRLALRADERWLELEAAAGEKLLERAGVLNMSDPDVYTFDGRLDDALKLGVRLEMLDVPEIVKRWPGVRLPDTYRAMYEPDAGYLYSERCVAAYKKLALKAGAELVTNTFVTDVKAENSIVSVRTKDDTFLAGHVVLSAGAWFKTLEPFIKLPIRAVRKSVAWFEPRGTLFDAGTFPGFTLGTKAGGYYGFPNIAGAGVKLGRHDTGVEWTPGEPFEPFGAYPEDEGYLRRTLETFLPDSAGKLLNGAACKYELTPDDNFIIDTHPHHSNVILAGGFSGHGFKFASVVGEIAADLIERRVSDQDLRLFSVARFAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS80</accession>
    <name>A0A398CS80_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02657">
        <property type="protein sequence ID" value="RIE02657"/>
        <property type="gene ID" value="D3H35_18435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="131" mass="14974" checksum="E171483DAEE42E41" modified="2018-12-05" version="1">MTESELMQIRKFVHLTCLIKVAINTINDLSESRISFKSMPISITKLFGKRIRNDLKELQKEMRANVVHAWLEDNGEDVVYVHTSIKGVNGRHGIKRKILNEDLQDKIEDYANQFGKMSIDSPYVLDPGGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSC4</accession>
    <name>A0A398CSC4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.63</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_18755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.63" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02697">
        <property type="protein sequence ID" value="RIE02697"/>
        <property type="gene ID" value="D3H35_18755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019700">
        <property type="term" value="P:organic phosphonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012696">
        <property type="entry name" value="PhnM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038971">
        <property type="entry name" value="PhnM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="200"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="400" mass="43170" checksum="0ABF0E1F2B5F20C1" modified="2018-12-05" version="1">MNGKRLVVRGGNVVLPDGVVKADVVAENGIIQSVDYAGSKSSAVETIDESKDRIIEAEGAWVLPGLVDIHCDTIEKEVEPRPGTLFPMEMAFLQYERKLAGHGITTMMHSLSFGVGLSLRGEHLVSQLIDLIRSCSRERAMIRHGVHLRYEVSQPTGIPLARRLIEEGAIDYLSLMDHAPGIGQYARPGAFQRYVMKNQGVSLDEVEKIVEELQERRAKVDWNALRELTAFARSRGIAVASHDDDSEEAVNRSLAFGADISEFPLNGATAAYAKKQGMGVCVGAPNIVRGGSHDGNLKAAEAIVAGDANLLCSDYHPASLLHAVFALAKEGVALERAVRMATLEPAIAMGRGAEIGSLEPGKRADLIVVDTVRECPLVRCTVVDGVTVYETRDFSGAKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSJ6</accession>
    <name>A0A398CSJ6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="3 8">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purD</name>
        <name evidence="11" type="ORF">D3H35_16690</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="3 8"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02351">
        <property type="protein sequence ID" value="RIE02351"/>
        <property type="gene ID" value="D3H35_16690"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="107"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE02351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="419" mass="45399" checksum="A8CD1675595A09CD" modified="2018-12-05" version="1">MQILVIGRGGREHAIIWSLKRSDKVKRIYCAPGNAGTAQLAENVDITELEFDRLVQFAQDNAIDLVVVGPDDPLAAGIVDAFEAKRIPVYGPRRNAAEIEGSKIFMKNLLRKYDIPTAKYETFTDYETALDYLRKQELPIVIKADGLAAGKGVTVCFSREEAEKALQETMVDKSFGSAGDKVVIEEFLEGQEMSILAFVDGETVRPMSPAQDHKPVFDGDKGPNTGGMGTYSPLPHIDQAIIDEAIENIVIPTAKAMVSEGRPFRGVLFAGLMITKDGPKTIEFNARFGDPETQVVLPRLQTDLLDIFLASINGRLNEIDIAWSDDAAVCVVLASEGYPGSYPKGLPIKGLDEAGDALVFHAGTAVKDGEIVTNGGRVLGIVGRGPDIKAAREQAYEAAERITFKGKHNRIDIAAKALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSY1</accession>
    <name>A0A398CSY1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_20165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02927">
        <property type="protein sequence ID" value="RIE02927"/>
        <property type="gene ID" value="D3H35_20165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="92" mass="9709" checksum="30E673FBF1FB99F6" modified="2018-12-05" version="1">MLLKEVLKGVKKEILNLADAALTSGAANVGKELSNMKRDVNQPNDINLGAITSALKSGVLVTGQDLLTRGLERVGIPPQAVKSKVSEVSKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT06</accession>
    <name>A0A398CT06_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_15150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02094">
        <property type="protein sequence ID" value="RIE02094"/>
        <property type="gene ID" value="D3H35_15150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="245" mass="27018" checksum="1A7F09A52381FAC3" modified="2018-12-05" version="1">MEQSVIIEANDVWKTYGTGARAVEAVRGVSFELRQGEIVSIMGPSGCGKTTLLNCLAGMDTLDRGAVRIDGVELHKLSERGRDAFRAERLAFVFQFYNLVPVLSALENVELPLLCQGVPRKEAQRRARQALVRVGLKDRESHRPGELSGGQQQRVALARAIAHEPKVVFADEPTGALDRKSNEMMMDLIEHINRKDGISFVIVTHNPKVASYAHNTFYMDSGKMILEQRSAAMEGSRGMQGDGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTA2</accession>
    <name>A0A398CTA2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Galactose/methyl galactoside ABC transporter permease MglC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mglC</name>
        <name evidence="7" type="ORF">D3H35_17785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02541">
        <property type="protein sequence ID" value="RIE02541"/>
        <property type="gene ID" value="D3H35_17785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030158">
        <property type="entry name" value="MglC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32196:SF18">
        <property type="entry name" value="PTHR32196:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="337" mass="35269" checksum="BA7BFB94A1747C91" modified="2018-12-05" version="1">MNASAKKINLFLTQYAIYIVLVLLIAGIALYDTNFLSLGSLQNILYQNSTKAIIALGAAFILITGGTDLSAGRVVGLSAVISASMLQMADYPQKFFPNIGELPIFVPVLLAIAVGLIVGLINGLVVSKLNVPPFIATLGTMVIVYGANSLYFDMPPNNSQPIGGLRAGFTKLGTGSIELGPFKLHYLVIIAIIVALICWVIFNKTRLGKNMYAIGGNVQAAHVSGINVSRNLIMIYSFAGALYGLAGVLEAAKSGGASNNYGNMYELDAIAACVVGGVSTAGGIGTVPGVMAGVMIFGVINYGLTFIGVNPNYQLVIKGLIIVVAVAIDIRKYLAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTP0</accession>
    <name>A0A398CTP0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_16585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02334">
        <property type="protein sequence ID" value="RIE02334"/>
        <property type="gene ID" value="D3H35_16585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="24"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="388" mass="42558" checksum="8A8C6A39FE9E1C3F" modified="2018-12-05" version="1">MLAIDVQDLRKQFKVQKNREGLKGALQDLFKREHTEVTAVKDISFQIPQGEICGYIGENGAGKSTTIKMLTGILVPTSGKLLVNGYVPYKERETFVRGIGVVFGQRSQLWWDIGVIESFRLLRKVYQVSEADFRSRLDELVETLQLQELLNRPVRKLSLGQRMRCELVAALLHNPSILFLDEPTIGLDIVVKTEIREFLKRLNREHGTTILLTTHDLQDIEALCSRVIMLDDGRIIYDGGLEELKTRWGKGREVQFQFTDPVRLPKVAALTDGLDGLRWTLENEVTAKVWIPRDMNVSEVLSRVVGAIEISDIKIFETNTDEIVREIYSSGSAEAPKEVEIAAGLGDSAADSAESGTDGESGEAGGAGTSSAAAAAGAGSGTGAGERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUL9</accession>
    <name>A0A398CUL9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02684">
        <property type="protein sequence ID" value="RIE02684"/>
        <property type="gene ID" value="D3H35_18665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="76" mass="8515" checksum="BBBB238664CDFA15" modified="2018-12-05" version="1">MRITAISAYEYQRVYGVSSVERSARPYAAFPFRENDPLREERSPSGRAGKRTGARSKRGDCSPIGRERQPAKPPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVF9</accession>
    <name>A0A398CVF9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05289">
        <property type="protein sequence ID" value="RIE05289"/>
        <property type="gene ID" value="D3H35_01590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="109" mass="12811" checksum="5376C0BD8C1BEBA9" modified="2018-12-05" version="1">MSENNLLRDVFDAIADPTRRRLIRLLADTEEIPLHELTAQFQMGRTAVSKHLTILKEAGLVIDRKVGRETRYRLNAAPLREIQDWLAFYSKFWSTNMLRLNLLLEEDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVK1</accession>
    <name>A0A398CVK1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_00675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05339">
        <property type="protein sequence ID" value="RIE05339"/>
        <property type="gene ID" value="D3H35_00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005690">
        <property type="entry name" value="GerBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="493" mass="54127" checksum="D1EED2A840A89A26" modified="2018-12-05" version="1">MSEARSKEEPKWSEDRVRELFRNSADVIVQKCQIGDDSSTDIVLAYSDGLCDSSQIGLVVLPGLSKLVSEKGTLDDDSVWMAGKLPLVTFDETPTSGQLSESVFQGDLLIFILQSGTAYRLSIGNLPRRSPSESNTEISIKGPKDGFVEDIVVNVALIRKRIRSSDLCNESFTIGRRTKTRISLLYFHDIISPDVLKEVKRRLSQIDIDGIYGSGQIEEMIADSKYSMFPLFASTGRPDYTVNSLLAGRFVLIVDGSPLALIGPAELSLILKSPEDIHFNYAYVSFARVVRGASLFISLFLPGIWVALLAFHQDQIPFRLMATISVARLGLPMSVQMEMFLLLMLLEVFREAGVRLPSSIGQTLTSIGGLIIGDAAIRAGLVSPSIVVVGAITAVSGVTLVNQSLSTIISILRLFFFAMGAFLGMFGIILGMIVLAAYLSRLQSFGVAYMGALSPPRFNSMLRSYLRVPWQFMKKRPLFLKPGDSDHQGDEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVK3</accession>
    <name>A0A398CVK3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_20875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03044">
        <property type="protein sequence ID" value="RIE03044"/>
        <property type="gene ID" value="D3H35_20875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="7"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="404" mass="43552" checksum="98D29FF86E08C378" modified="2018-12-05" version="1">MQRWQINLAVLWFGNFLVMAGMTMIIPFLSLYLKKDFGLTDSHEIGVWAGLIFASNFTTSFLFQPIWGKLSDKYGRKMMLLRSGFGMSIVMVLMGFAQAPWHLLALRMLNGVISGFSPAAVSLVSSTTPKEKMGFAMGTLQSGGTAGTILGPFIGGLLADSLGFRPIFYITGTFLFLASTLSWIMVKENFDRDAAAHTPQQSVLTGLKSLMAIPQLPALLSVTFLIQFAMLSPMPLIPLYVEKLHGTEANLAFFAGFVGSVTGLSNMVSSPLLGRLGDRIGSTRILIISLAGAAFMLIPQAFVGTVGQLLVFRFLLGCFLGGMIPTVNALIRRYTPDNMVSRSFSFNGSSLALGNMIGPVVGGALSGLIGIEGIFIFSASLLLVTCVWAYRTLRSPARSSGEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVM3</accession>
    <name>A0A398CVM3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03917">
        <property type="protein sequence ID" value="RIE03917"/>
        <property type="gene ID" value="D3H35_08095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="28"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="335" mass="37400" checksum="134150520628219A" modified="2018-12-05" version="1">MSDLSPIWTEHAHGWLQVKIPLPFSLKWVNSYLLPGDAGWTMIDPGLRTEEAIACWDSVLDQVGIDWSGISSIVVTHHHPDHYGLAGLAQMRSGAPIWMSQTAMKTARRLWGKDETFSAELTEAFVKHGLPSELEQSMLEHMTGFREKVSPRPERPDIRILEPGTEFKMAGAIWEIIGGEGHAPGHVSLLDRRRRLLLCGDQVLPQITPNIGWMPGGDPDPLGSYLQTLRSMLGLPVDIAFPGHRDPFSRFDERVLEIAAHHDRRLSHMLELVGDGSISTFELCEATFGARLRGNIHNLRFALAETIAHAVYLEKSGKLIRAADFDGSIIRFRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVU6</accession>
    <name>A0A398CVU6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="11">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">trpB</name>
        <name evidence="13" type="ORF">D3H35_03985</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TrpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="11"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04658">
        <property type="protein sequence ID" value="RIE04658"/>
        <property type="gene ID" value="D3H35_03985"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="57"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE04658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="400" mass="43647" checksum="3D22FBF21DA5E2DF" modified="2018-12-05" version="1">MSQTQVPDQHGRFGAFGGKYVPETLMNALIELEEAYNRYKDDPDFLEEVRYLLKQYSGRPTPLYYAERLTEHLGGAKIYLKREDLNHTGAHKINNTIGQAVLAKRMGKKKVIAETGAGQHGVATATVAALMGLECKVFMGEEDTKRQQLNVFRMKLLGSEVVPVLSGTRTLKDACNETLRYWVSHVEDTYYILGSVTGPHPYPMMVRDFQRIIGLETRDQIVEAEGRLPDVIIAAVGGGSNAAGMFHPFVGDKSVRLIGVEAAGRGVDTDEHAATMSKGRPGVFQGSLSYVLQDEGGQVLPAHSISAGLDYPGIGPEHAYWKDSERAEYAPITDAEALEALKLLSRKEGIIPALESAHAVAHALKVAPSLSKDKIIVINLSGRGDKDVESILSYEAEGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW14</accession>
    <name>A0A398CW14_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MBOAT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_04390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04728">
        <property type="protein sequence ID" value="RIE04728"/>
        <property type="gene ID" value="D3H35_04390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024194">
        <property type="entry name" value="Ac/AlaTfrase_AlgI/DltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028362">
        <property type="entry name" value="AlgI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500217">
        <property type="entry name" value="AlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016636">
        <property type="entry name" value="AlgI_DltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE04728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="460" mass="53089" checksum="E48AF68EE8868502" modified="2018-12-05" version="1">MVFSSLLFLFLFLPAVLALYYGAPWRIKNLILFLTSLVFYAWGEPVYIVIMLLSTVTDYSFGLLLSRPTLNDRQRKTIVAVSVVVNLGLLSYFKYADFLINNVNSSLGTSIPLTDLPLPIGISFYTFQSMSYIIDVYKGKAKAQRNWIDFGTFVALFPQLVAGPIVQYSVVAEQLRHRTVNVEMFAAGVRRFVIGLAKKVLLANNIGMLWHTVSSSNLDTMPALTAWLGIIAFAFQIYFDFSGYSDMAIGLGLMFGFRFNENFNKPYVSQSITDFWRRWHISLSSWFRDYVYIPLGGNRKGKWLQLRNILIVWLLTGFWHGASWNFVLWGLYFGIVLIVEKMWVLKRLKRLPRWMRHVYSLLLILVGWVFFAFDQLSNVVSYFAAMFGRNDQPIWNDDTLYLLYTNAILLCILAVASISLDDRLRSRFAPLQLGWYAALFVMSLAYLVDATFNPFLYFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWA1</accession>
    <name>A0A398CWA1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome C oxidase subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_09140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04097">
        <property type="protein sequence ID" value="RIE04097"/>
        <property type="gene ID" value="D3H35_09140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017264151" evidence="1">
        <location>
            <begin position="23"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="2">
        <location>
            <begin position="38"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="127" mass="13376" checksum="96CBADCC6B97E46D" modified="2018-12-05" version="1">MKSKLFLFLTIIALAFALAACGSKKENSGASPSSAETPVAASAEVVIKAQSWEFDKAEYEVPANTPVKITIENTKGAHGIKVDGTDIDIGPGKESQVVTLEPGTYDFSCSIMCGSGHRKMVGKLIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWD9</accession>
    <name>A0A398CWD9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4303 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_05290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04878">
        <property type="protein sequence ID" value="RIE04878"/>
        <property type="gene ID" value="D3H35_05290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025409">
        <property type="entry name" value="DUF4303"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14136">
        <property type="entry name" value="DUF4303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="326" mass="37821" checksum="E35B6B0940AF9BAD" modified="2018-12-05" version="1">MPKSIDLAKIKKMLIQHGEKTIRSFAKTSHNKDVYAFVLDAQATHGSVNFRWNTLEGIAYTCTFDSYKNYTDDRLYGHRGLKYSVGDFRFEDPGNEKLEKWGMKYEEVLDILWETDEDQAEQIPAAFMDVLIQVVKELIPVLEELHLTDDFIAYAVEHDEEDMKFIPQTVSPAQLEKVFPELKAYEAYKERIGLRPPIDQAAFWCQTLADFEEACESEAVVELRRLSRHSFDVQEELVRLGEVSVPILITYLERALDQLPAQTSINDRLNVWTYQSTLIDIAKARETEISRLQAIYARLNQDRPENQDTKNTLRVLHAIDPLRFPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWK8</accession>
    <name>A0A398CWK8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04948">
        <property type="protein sequence ID" value="RIE04948"/>
        <property type="gene ID" value="D3H35_03155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="279" mass="30442" checksum="02ADDBF8CC383D92" modified="2018-12-05" version="1">MFEEQVKKTPDHTAVVLESESLTYAELNGRANQLARVLRGKGVGADRIVGILAERSLEMIVGILGILKAGGAYLPIDPDYPAERIGYMLEDSGADILLTQKRLQGQTMGFAGEVLHVDDERLYALDNTDLDHTGSSKDLAYVIYTSGSTGKPKGVMIEQDGVINALLWRKQAYGFNETHSVLQLFSYSFDGFVTSFFTPILSGARAILLQDTRNPYAIVKAIATSKVSHFICVPSLFQAIQEYLSPQDAEHLQVITLAGEKADSGVIEKRLAGTDILNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWL3</accession>
    <name>A0A398CWL3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000035">
        <property type="protein sequence ID" value="RIE03601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03601">
        <property type="protein sequence ID" value="RIE03601"/>
        <property type="gene ID" value="D3H35_10705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="87" mass="9919" checksum="1109F17E964A5FFA" modified="2018-12-05" version="1">MFEVNLRLDRRWSVEYCPSCVRSRRISHLAVVPFDEGTVLHQLFERGVDAGADEIDLRLDGPLSACIRAPNRVISTFRADHPVNLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWQ5</accession>
    <name>A0A398CWQ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">5-oxoprolinase subunit PxpB</fullName>
            <ecNumber evidence="6">3.5.2.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pxpB</name>
        <name evidence="6" type="ORF">D3H35_10090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.9" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03641">
        <property type="protein sequence ID" value="RIE03641"/>
        <property type="gene ID" value="D3H35_10090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010016">
        <property type="entry name" value="KipI_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00370">
        <property type="entry name" value="TIGR00370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00724">
        <property type="entry name" value="urea_amlyse_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS1" evidence="4">
        <location>
            <begin position="5"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="AHS2" evidence="5">
        <location>
            <begin position="262"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="591" mass="62323" checksum="71536A7B47764609" modified="2018-12-05" version="1">MANGMFIRHLGDRALLFAWNERVVPKASMASLAAQIRQWKVPWIGDVVPGYATIAVHCRGASPAEEAAAALAERIAACEGAELPEPRTLTVPVRYGGEDGPDLEACCARCGLTEEQFIERHSGTVYEVAMIGFAPGFPYLSGLDDALAQPRHETPRKRVPAGSVGIAGGQTGIYPVASPGGWQIVGRTDERLFRPGEEEPFALTPGDRVRFVPAAKLDAADEPQSANAREQEAEGEGAAVLTVVSPGLLTTVQDLGRPGWQAWGVSVGGAMDSIALRTANILAGNGEEAACLEMTLVGAAFRVERDTVLAVSGGLSAASIDGERLPAERPVWVRAGATISFGSMSAGCRTYLAIAGGIDVPVVMGSRSTDVRARIGGVGGQPLERGTRLQGGALSEQSHILHQWLRNKSLREDRAWTTVPWSASTVRKGSFSEGNPGSASAISLRVLRGAEWGRFAPESRARLFEQPYRVDVSSDRMGIRLKGSPLRIEAAVELSSHGVAAGTIQVPPGGQPIILGAGCQPTGGYPKLAHVIGSDLPLLGQAAPGALVRFVPTNREEAAKEARRADGELAELKAGVLLKIRADMERISSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX09</accession>
    <name>A0A398CX09_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1507 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04367">
        <property type="protein sequence ID" value="RIE04367"/>
        <property type="gene ID" value="D3H35_07180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009983">
        <property type="entry name" value="UPF0358"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036270">
        <property type="entry name" value="UPF0358_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07408">
        <property type="entry name" value="DUF1507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140404">
        <property type="entry name" value="SSF140404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="97" mass="11048" checksum="F5D74171819365D6" modified="2018-12-05" version="1">MASSDTIEHLNQKAIRLLQEDADKIEKLIAIQMENLATRKCPLYEEVLDTQMYGFSRAVDFAVRAGLMEEGAGKQLISQLERNLALLYEAMERNSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX17</accession>
    <name>A0A398CX17_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04377">
        <property type="protein sequence ID" value="RIE04377"/>
        <property type="gene ID" value="D3H35_07250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="145" mass="17639" checksum="D5ADD1B3ABA6BBF8" modified="2018-12-05" version="1">MKDKHTERWNTYEPFHVVLGDKRVVDIIITNHARQRWTDRVESEKTGYSDIAQYMWECLKEDRIISYYRNEQDVYTIDDDLVFVAEFSVSEKDVDLLGNPLHKMIVVTFLGRMSETMELRDLKTYYSWLRHSRRMTLIKNNRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY51</accession>
    <name>A0A398CY51_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_04330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04717">
        <property type="protein sequence ID" value="RIE04717"/>
        <property type="gene ID" value="D3H35_04330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005741">
        <property type="entry name" value="TopoIV_A_Gpos"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43493:SF9">
        <property type="entry name" value="PTHR43493:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01061">
        <property type="entry name" value="parC_Gpos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="9">
        <location>
            <begin position="10"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="825" mass="91014" checksum="D366FA8A6476F493" modified="2018-12-05" version="1">MSLLEQFLPAFLEEVVGDRFGRYSKYIIQDRAIPDVRDGLKPVQRRILYAMYDSGNTPDKPYRKSAKTVGDVMGNYHPHGDSSIYDGMVRMAQPWKLAHMLIDGHGNWGSMDDDPPAAMRYTEARLSTIAMEMLRDIEKRTVQFKDNFDNSTKEPVVLPSRYPNLLVNGVSGISAGFATEIPTHNLREIIDACIAVMNKPDITVAELMTIVKGPDLPTGGIIMGEEGIREAYETGKGRMYVRSKTAIEDLRGGKQQIVVTEIPYQIVKSKLVNAIDNLRIEKKVEGIAEVRDESGRNGLRIVIELKKDADPHGILAYLLKKTDLQITYSFNMVAIVNKAPRQLGIKPILEAYVEHQKEVVTHRTQYDLEKAEDRAHVLEGLVKALNLLDAVIETIKASKNRQDAQNNLVAKFGFSERQADSILTLQLYRLTNLEITSLEKEHADTLKKIAQLRSILDSPRKLLGVIKDELTEIRDKYGIDRRSVIQGEVEEIKVNLEVTVPAEDVLVTLSREGYVKRTSLLSFTRSGGELGSAGVKEGDVIRWSLGVSTLDPLLLFTQKGSYFLLPVHQIPEFKWKDTGTAVVNLLPLAKDDRIVGIIPVKPAEFAAAPSAGEDAAGPALVFVTKRGQVKRTLLTDYATTRSMAIAACKVAEGDEIIKVFRSSDSSEDLMLVTEQGMSIKFGLGEVSLQGRVAGGVRGIALKENDAIADAIPVAGDEGEIMVLSDYGYAKRTLLLDYPVQGRGGKGIQTFEFKEGKRVRPNGTKLVSAFHVKEAVTVQAMTAGGTLTEFHSESAPIEDRRGQGKAVAAAERSDLLVESFLKPLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYR5</accession>
    <name>A0A398CYR5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_00955</name>
        <name evidence="3" type="ORF">D3H35_03300</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04977">
        <property type="protein sequence ID" value="RIE04977"/>
        <property type="gene ID" value="D3H35_03300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05385">
        <property type="protein sequence ID" value="RIE05385"/>
        <property type="gene ID" value="D3H35_00955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="158"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="279" mass="31690" checksum="F304CC335258A1C2" modified="2018-12-05" version="1">MSMSNESLPVNFIEINFPNSSEWSSSHFQIVWESGMENMQDSTSIAMVRPDLPIAKPTPHASVISILFEADFLTKQKNLMNAKMPLEMPLNGYSKTILSQILEYGKQSSSNSWKKRIACAIFSLTIEFLDFFSSGQQSPPSLFSKPKGTEPKEAKAIIYATRYIRNHMANPDLSLDELAQAIGYNPNYFCQEFSRILSVSPIRYLNKLRLDRAMRLLEHSDHSVRTICNMVGIRNPSRLASMVKLASGMNPLVLRRTKKLQNLMYNQPTNTSISFKKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ42</accession>
    <name>A0A398CZ42_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">16S rRNA (cytosine(967)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">16S rRNA m5C967 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">rRNA (cytosine-C(5)-)-methyltransferase RsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">rsmB</name>
        <name evidence="14" type="ORF">D3H35_07345</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(967) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42748"/>
            <dbReference type="Rhea" id="RHEA-COMP:10219"/>
            <dbReference type="Rhea" id="RHEA-COMP:10220"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.176"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.176" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04501">
        <property type="protein sequence ID" value="RIE04501"/>
        <property type="gene ID" value="D3H35_07345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004573">
        <property type="entry name" value="rRNA_ssu_MeTfrase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00563">
        <property type="entry name" value="rsmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="13">
        <location>
            <begin position="210"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="300"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE04501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="494" mass="54148" checksum="FABE1BEAAF63A4C5" modified="2018-12-05" version="1">MFVQDILWKKRGIGVSDSKTTHKTHKRKTGTAAQPAATRKPKGPREVAMDILKRIDTDGAYSGLELNKALSASGMSRQDAALATEIVYGTIQRLATIDRVLEQKVKGWPSKVEPWARSLLRLSYYQLRWLDRVPAHAVVDEAVRLAKKRGHAGIAGLVNGVLRGVLRDGVVQPLPANLPPAERIALEHSYPGWMVERWIADYGAEIAEAICAAGNVPPHASARVNRLRTNRDDLLASMKEAGVYAGESPVSPDGIIATRAGSLVSTDWFKEGQLSIQDESSMLVAAVADPRPGMAVLDCCAAPGGKSMHLAERMENRGDVFANDVHPHKKALIDEQAERLGLGIVRTMTGDAKELSLVLPTESMDIVLLDAPCSGLGVIRRKPEIKWNKQPQDVESLSALQGELLQSVRALVKPGGTLVYSTCTVAKEENERAIRSFLERNPEFSLDPDWPEEVLRPLRQAEGVLPQPFEGMLQILPHQFGSDGFFIARMKRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZQ7</accession>
    <name>A0A398CZQ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_07410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04404">
        <property type="protein sequence ID" value="RIE04404"/>
        <property type="gene ID" value="D3H35_07410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="245" mass="27695" checksum="C32427E21A801939" modified="2018-12-05" version="1">MADKGERMDRVTLFMFPYAGASASVYEKWKPLFHESIDIVPVEIPGRGKRFPEPPLRRIGPIVEDAYTRIEGQLSERPYALFGHSLGSVVAFELARKAKRLGKKPPVRLFVSGRAAPQVKELDEPVYLLPDERFKQKIRSLGGTPPEFFQNEQLLSLFLPILKADYEASDTYRDEADASDKLSCGMTVLHGTEDEPCDPSEWSVHSTGTSDFHEFEGGHFFINEHAKPVAELINRLLCTKEERTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0F1</accession>
    <name>A0A398D0F1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_03905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04644">
        <property type="protein sequence ID" value="RIE04644"/>
        <property type="gene ID" value="D3H35_03905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="179" mass="20273" checksum="7B94E639FB7AE0B2" modified="2018-12-05" version="1">MAHWLRFGGLLATGFAVVLLLGRLPAIERSPPSHRQSLEVFTPVQVKTLTGENLVDAMIGLPLRERLSRVGWDHSILTVDLSVEQPLAAPRDVWRDTARLIRFSFFDVQGVRQLLVRVYSVDGGQRTLLFSAETRPGDWTEERLASLRTPIGYPDDEFRAGIHLVIYPQGELWLRNFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CAR3</accession>
    <name>A0A398CAR3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00226">
        <property type="protein sequence ID" value="RIE00226"/>
        <property type="gene ID" value="D3H35_29775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="168" mass="17624" checksum="C59C9E217EA5E36B" modified="2018-12-05" version="1">MINDVFAAAQTGNAPQLMRLLSSNPALANMENAEGLTPLGFAAHFGHAQAAAVLLDYGAVINALSHSKVGYIPSNTALHAAIAGERSMEVIGLLLERGAATNIFDSNGHTCLHVAAFHDDNWEMANLLIEFGADVHAKREGGASALSIAIERGNLKVAELLREKGAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD85</accession>
    <name>A0A398CD85_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage tail protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00670">
        <property type="protein sequence ID" value="RIE00670"/>
        <property type="gene ID" value="D3H35_27295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011083">
        <property type="entry name" value="Phage_tail_collar_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037053">
        <property type="entry name" value="Phage_tail_collar_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07484">
        <property type="entry name" value="Collar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Collar" evidence="1">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="174" mass="18428" checksum="08DAEA43E9119771" modified="2018-12-05" version="1">MDPYVGEIRIFAGKYAPNGWALCDGSLLPVQSNQALFSILGKTYGGDGRTTFGVPDLRGTAPMHQGTGPGLTPRPYATSGGQNTVTLLESQIPNHTHVPLIQTTASQSSAAQAIWATSPGSSKTARKIYSNNVDTPMNPMAISPTGGNQAHNNLQPYLTMNFIISLEGVYPLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDF8</accession>
    <name>A0A398CDF8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01216">
        <property type="protein sequence ID" value="RIE01216"/>
        <property type="gene ID" value="D3H35_22740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="293" mass="33725" checksum="B0911CF543F0B837" modified="2018-12-05" version="1">MLQQLNHLMDYIETHLTEEISGKDISRIVGLSDYHFKRMFSYMAGMSLSEYIKNRRLSVANVELINGARVTDIAYKYGFQSIEGFSRAFREWSGFLPSEVTKNKIQKSFPKFLFFIDIRGGISMEFKIEKKEKFNIVGVSKRVPIQFEGVNHAILELAQSITEQQRNEMHQLADLYPHQVLNVSYEFDEGFLEEKGNLTHMIGFATTKENTFDDLEQLSIEESLWAIFPNQGPFPVTLQETTAKIYSEWLPSSGYEAADIPGISFTKHNGTSENVYSEIWMPVRKKIEINSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDK9</accession>
    <name>A0A398CDK9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SPOB_a domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_27605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00515">
        <property type="protein sequence ID" value="RIE00515"/>
        <property type="gene ID" value="D3H35_27605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016120">
        <property type="entry name" value="Sig_transdc_His_kin_SpoOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039506">
        <property type="entry name" value="SPOB_a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14689">
        <property type="entry name" value="SPOB_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55890">
        <property type="entry name" value="SSF55890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="SPOB_a" evidence="5">
        <location>
            <begin position="104"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="294" mass="32859" checksum="E7FD7C37FA51B036" modified="2018-12-05" version="1">MAGVFALRDASFPIHGIMGAVNRFPQSGAVCKEKRNETGKVSTMDKKKWQIGAAASLVVPITALLLWREAGWSLILFVVWTIAAAAAAVALERRHGREQTIRMREHSNRTLIRTLSHHRHDWLNELQLVYGYLRMSKSDKAVGVVERIRERMNHDSKVTHLGSPELIAYFLTFRTLCNTMRLDVEVEEGIYLDRLFPNSDKLPDVIIGLVNAFRRRAASAEVSANVLKVSFSKLEKERRLVIALGYEGELASIDSLESELNGLLDGWGTIASEEAGAEEHTKAHRMAAHIPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDV4</accession>
    <name>A0A398CDV4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000051">
        <property type="protein sequence ID" value="RIE00615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00615">
        <property type="protein sequence ID" value="RIE00615"/>
        <property type="gene ID" value="D3H35_27535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="176" mass="20758" checksum="B65632DD51659E03" modified="2018-12-05" version="1">MNFPWERYSHVEVRTQYEDPEHRISQADSFVLSKETVTEASWKMFVMDSGKTRFRYKIIYRAVDFRDVELPWMETDEERLTIRDPFPTKRTLEIVPLFDWTKVDGLSWTSRTRTRIMACSKSSLSNSTISLSRPGALSLHSRTQTGGRSDSKRRLFAKTERCPRFRSRIPSRDVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEE1</accession>
    <name>A0A398CEE1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00222">
        <property type="protein sequence ID" value="RIE00222"/>
        <property type="gene ID" value="D3H35_29755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="462" mass="50992" checksum="4F2ADF31760FB998" modified="2018-12-05" version="1">MFIRAAEKAPGDWSTWKATFSVTEPGIHILTARCTDLANNTIEKTVSVNVTILPEVSSRLKRIILVESYRMSSFLGNYGAGGMIKTTSLLPGEKTKISIRSYTQSEESAKTASTILDSVTDDIADEFEKSMGNEQTDQKNYKESFEYKVSAEAGASWGWGSASISASASGGTNAARDQFARNISNSTQKHVARASARRDVQINTNYEVKTTAGEESSIIREIENINVSRTLNFVFRQMNQEFITLLHLVDLRIGFFKVDIVNGQEKHTYTEVTLPQLDALLGDIIIASKRQEVRNAIINQMTNIFDYQDRHHRFVEEEPFKDENGNVIPLSNYLRVKKDYVSTYADEAAGTNISVPGIILAANRHVLRTEGVIVEALLGQGEALDDYSRNLQSETVREKSLRNDLLESEMKMKLLALDILESRDELAAKIYGLLNPAPVIVEGDSEASGSSASGSGVLAGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CER1</accession>
    <name>A0A398CER1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iron-hydroxamate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_22185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01656">
        <property type="protein sequence ID" value="RIE01656"/>
        <property type="gene ID" value="D3H35_22185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017182833" evidence="2">
        <location>
            <begin position="36"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="81"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="332" mass="36578" checksum="84FF6CCCB0D8CF8E" modified="2018-12-05" version="1">MTPNGHLAKKLFVLLTAILIVAALSACGKNNDKNAASPTASASNSPSASPSASPSASAETATGTITYQSENGPIEVPANPQRVVVLSSYTGNVLDLGVPLVGVESWSKSNPNFQEQLKDVQEVSDENLEKIIELQPDLIIGLSTIKNVDRLKQIAPTVTYTYGKVDYLTQHVEIGKALNKEKEAQAWVDDFKKRAQELGDQIKAKIGSDKTVSVIENYEKQLYVFGDNWGRGTEILYQAMKLPMPAKVSEMTKKDGYYALSQEVLPDYAGDYVIFSKNPDADSSFQQTDTYKNIPAVKDNHLFEVNAKAFYFNDPISLEYQLEFFKQKFLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CES0</accession>
    <name>A0A398CES0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_22450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01666">
        <property type="protein sequence ID" value="RIE01666"/>
        <property type="gene ID" value="D3H35_22450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="334" mass="34733" checksum="DB5423698479CBCF" modified="2018-12-05" version="1">MKPKKTYAICLWFIAAVAILILSTFIAISYGAKSLSLSSVWSAVFQYDPTATSDQIVHDIRLPRVLGAVVTGMAFAAAGAIMQGVTRNPMADTGILGVNAGASFVVALSFAFLPGLAYSGLIVMSFTGAAIATLLIVLLGSATPGGLTSIRLTIAGAVVAAMLHSLSAGIAIYFDLSQDLAFWYAGGVAGVKWSQLKLLAPIILAALIWAISMGRSITFLSLGDESAVSLGIDTRRVRILGMTAAVILAGASVSVAGAIGFVGLVVPHIARRLVGVDYRVVLPLSALLGSILLVWADFASRMVNPPKEFAIGAMVALVGVPFFLYLARKEGRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF91</accession>
    <name>A0A398CF91_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_21870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01075">
        <property type="protein sequence ID" value="RIE01075"/>
        <property type="gene ID" value="D3H35_21870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="329" mass="36571" checksum="080A97580857A4ED" modified="2018-12-05" version="1">MADIHTVAKEAGVSVATVSRVLNNHPSVSLKTRRKVEEVIEKLKYEPNMLGKSLRSSQSRLLLALIPNISNPFYAKVVSGIESVAKANRYNIMLCTTDSNPERELLYYDMVKKKLAEGLISIDPSSEFYEMLTTTNRYPVVICGEHVGNDHAPCVSIDNAKAAYKAVKHLIALGHRKIALVNSNIYTAGLRQQGYLKALEEHGIEVNPRWIAHADLNFENAQQDVRELLMTEDRPTAVFAVSDTIAISVLKAAKDLDIKVPEELVVSGFDNIDFSSVMNPTLTTISQPMFEMGSHSAAMLFKRIADRSAAIKNVILDHDLIIRESTMNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFY5</accession>
    <name>A0A398CFY5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2 9">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argG</name>
        <name evidence="10" type="ORF">D3H35_15210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2 9"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02106">
        <property type="protein sequence ID" value="RIE02106"/>
        <property type="gene ID" value="D3H35_15210"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="Argininosuccinate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="9"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE02106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="412" mass="44997" checksum="11675DB6CDE92157" modified="2018-12-05" version="1">MAKEKIVLAYSGGLDTSVILTWLKETYDAEIITFTADIGQKDELDGLEEKAIKTGASKVYIDDLRAEFAKDFIYPMFQAGALYEGQYLLGTSIARPLIAKRMVEIALAEGATAIAHGATGKGNDQVRFELTAAALAPDIKVIAPWRDEAFREAFPGRAEMIAYAEKHNIPVQASASKPYSTDRNLLHISFESGMLEDPWFDSSAADVEDMYVLSVSPEKAPDQGEYVELDFEAGNCVAVNGNKLSPLEVMELLNELGGKHGVGRVDMVENRFVGMKSRGVYETPGGSILFTAHRKMESLTMDRDVMHLRDSLISKYASLVYNGFWFAPERLAIQALVNESQKNVTGTVRLKLYKGNVMAAGLKSPVSLYNPHIATMEADPTQAYDQGDATGFIRLNALRLKVSSGVTGASGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH83</accession>
    <name>A0A398CH83_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase T</fullName>
            <ecNumber evidence="7">3.4.11.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aminotripeptidase</fullName>
            <shortName evidence="7">Tripeptidase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Tripeptide aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">pepT</name>
        <name evidence="11" type="ORF">D3H35_13730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cleaves the N-terminal amino acid of tripeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Release of the N-terminal residue from a tripeptide.</text>
            <dbReference type="EC" id="3.4.11.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 9">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase M20B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.4" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01845">
        <property type="protein sequence ID" value="RIE01845"/>
        <property type="gene ID" value="D3H35_13730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045148">
        <property type="term" value="F:tripeptide aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00550">
        <property type="entry name" value="Aminopeptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010161">
        <property type="entry name" value="Peptidase_M20B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42994:SF1">
        <property type="entry name" value="PTHR42994:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037215">
        <property type="entry name" value="Peptidase_M20B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01882">
        <property type="entry name" value="peptidase-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="M20_dimer" evidence="10">
        <location>
            <begin position="209"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" evidence="7 8">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037215-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037215-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE01845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="412" mass="45443" checksum="66235394D4DF555A" modified="2018-12-05" version="1">MKNEILKRFTQYVQIDTQSDDSSDTCPSTPGQWNLARHLVYELQDIGMEDVTVDENGYVMATLPSNTDKSVPTIGFLAHMDTATDFTGANVNPQVVESYDGGDIVLNKALNIVLSPRDFPELSGYKGQTLITTDGTTLLGADDKAGIAEIMTAMAYLIAHPDIKHGRIRVSFLPDEEIGRGPHRFDVAAFGAKFAYTIDGGPLGELEYESFNAAQARITVKGVNVHPGTAKGKMVHSSKIAMELHTLLPVQEAPEYTEGYEGFYHLISIQGNTEQTKLVYIIRDFDKVTFASRKAFVESVVGQLRSKYGEDSIELELKDQYFNMREKIEPVKEIVDIAHDAMTNLGIAPIVKPIRGGTDGSQLSYMGLPTPNIFSGGENFHGKFEYVSLDTMVQAVRVIVEIAKLYEERAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHC8</accession>
    <name>A0A398CHC8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000059">
        <property type="protein sequence ID" value="RIE00308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00308">
        <property type="protein sequence ID" value="RIE00308"/>
        <property type="gene ID" value="D3H35_29250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="99" mass="11610" checksum="B5A1D6FE3597A3F9" modified="2018-12-05" version="1">MNDILLFTLIITLGINFGIYFRLIAKKRSTINYLFSKLKQILPDKAFESIIIINSSISEDIEILLSHKSGSWIILYNGPDWLFNIKKRKFGERCFYSMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHK6</accession>
    <name>A0A398CHK6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02253">
        <property type="protein sequence ID" value="RIE02253"/>
        <property type="gene ID" value="D3H35_16090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="131" mass="14939" checksum="7152491A18E356DF" modified="2018-12-05" version="1">MWLPIRIDEQRPEPLYHQIEVQLRGLILGGQLKEGTMLPSIRELAASLKCSAITVRRVYQDLENEGIIRTRQGTGTFVAGVDSGALDAHRLDRVAEELNRAIETGLQLHCSDEEMEKLFRDILKRKREETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHU1</accession>
    <name>A0A398CHU1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_29015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00448">
        <property type="protein sequence ID" value="RIE00448"/>
        <property type="gene ID" value="D3H35_29015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="178"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="280"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="541" mass="61838" checksum="A07B9913B260B745" modified="2018-12-05" version="1">MSRKPYLFQPEPVFRLMELEHVSSKPHEETIRQFVGDYIVLIVIGGSGALVIDGRPVALNRGKLMLLVPAMLIEIRSNPANPLRYYRIAFQALRETGRRNKTLTFAALDDSLQFPVGGELPDSLYNEALRVARLLHDSVQYERGRNHHEVYGLFHRLLALISDSGQAGGRGEAEEALRSTISYIETHYQEEVTRDTLAGIAGMSPWHYSRKFKELTGQSPSEKLESVRIGKAKEHLLRLDCSIPEVAQKVGYRDESYFRNKFKASTGYSPTMFVARRREKIAALSYHYASHLLTLNVVPFATYVEQSRESHRKEYHESIVCHLKRSKTLNAGVWEANLQALARAKPEVILCDELMDEQVRTCLEKIAPIVSIPWLELDWRSHFEEIAAFLGKRRESSRWLSVYERKAEQLRKQLRSKLGRGSVAVLHIMAGQLFVYGARNGGSVLYEDLQMSPVCDTSAIQVCKQITEEELLLYDGDRIFMAIDADEASRQCWDRIRRNDVWASLQAVREGRVHFVKEFPWLEYSPYAHSIVLDEAAGLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIE0</accession>
    <name>A0A398CIE0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_13540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01812">
        <property type="protein sequence ID" value="RIE01812"/>
        <property type="gene ID" value="D3H35_13540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025666">
        <property type="entry name" value="PQQ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13570">
        <property type="entry name" value="PQQ_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017330669" evidence="2">
        <location>
            <begin position="22"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="PQQ_3" evidence="3">
        <location>
            <begin position="326"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="PQQ_3" evidence="3">
        <location>
            <begin position="373"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="410" mass="44338" checksum="2CC88FA493E37078" modified="2018-12-05" version="1">MIFVRRLMVAVFCIVLSLSLAACSKGKEGAGANEKEAAAKPEPTPTVTASAGATDAMNGGAPSEPSGAVPAKEIAWKFKSDGSINGAPRAIDGVVYVGSYDKHEYAVSAETGEMIWKFQAEGAIRSAAAADGKNVYFVDCFGNLYAVDRATGKQTWHFKAEGDTLVQVDEWDYYDSSPVLEDNVLYFGSDNRFIYAIDAGTGKPIWSYEMGGPTHSTPTLKDGIVFISDWEGRIYALDGKTGKLKWKQVGMGSIQGSPAADESQVYFGTRLGTSFYALNALTGEQSWKWISSMGSWFVSTPVSHEGIVYSGSSDEYLVYAWDAATGKKRWTFNTGSNVNTSPKLAGGILYVTTAYAYEEKHDDHLYAIDPATGTPIWQVKVEQPLYASPEIADGAVYFASRDGYLYSVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJN3</accession>
    <name>A0A398CJN3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murA</name>
        <name evidence="9" type="ORF">D3H35_21655</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01048">
        <property type="protein sequence ID" value="RIE01048"/>
        <property type="gene ID" value="D3H35_21655"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetylglucosamine binding" evidence="7">
        <location>
            <begin position="121"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="7">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="416" mass="44475" checksum="C4E368527E4569F4" modified="2018-12-05" version="1">METLLIRGGRPLRGTVAISGAKNSAVALVPAAILAESEVRLDNLPQLSDVAVYAELLEELGGSVTWMDDRMTIDPSKMKSVPMPNGRVKKLRASYYLMGALLGRFGEATIGLPGGCNFEPRPIDQHIKGFEALGAEVTNDHGSIKIRAKELRGAKIYLDVVSVGATINIMLAASRAKGSTLIENAAKEPEIIDVATLLNSMGAKIKGAGTETIRIEGVDSMHGCRHSIIPDRIQAGTYMIAAAATRGDVLIDNIIPKHLEALTAKLQEMGVHVYEMDEAIRVVGQPDYEAVDVKALVYPGFATDLQSPMTSLLTQARGVSVLSDTVYNNRFKHVPELVRMGAQIRVEGRSAIIEGGLLNAAKVRAADLRAGAALVVAALTVPEGTTEISGVEYIDRGYDKLVTQLSNLGAEVWRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJN9</accession>
    <name>A0A398CJN9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02565">
        <property type="protein sequence ID" value="RIE02565"/>
        <property type="gene ID" value="D3H35_17920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="224" mass="25528" checksum="2E4E05E593E5DBE0" modified="2018-12-05" version="1">MTAKVYDKTGRLYQVKDGSTVQSTYVYYADGSQNTVTYANGSKEEYVYFKDKTLKTLKNYQGATLLDTYDYTYDAAGNQLTKNEKVNGANKGETNYQYDDLNRLKKVTEPGGKVTDYTFDAFGNRSSERTTQGAAVTVLNYSYNEQNRLIATAGSKVDGRIAASDLHVRQQRQYDRQVDGNHEEDRPGERTDANVWYLHLRSEQYELAHRAGCGQRSPLRVRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK40</accession>
    <name>A0A398CK40_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02512">
        <property type="protein sequence ID" value="RIE02512"/>
        <property type="gene ID" value="D3H35_17635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="228" mass="26712" checksum="6113F5ABA7FDC909" modified="2018-12-05" version="1">MEMLNQPFEAAYERMLHNALKTSGEERKRRLLKKHSHLEKLFLFNVWWPAMGNLDNLHPEYEIRDFKEGTRFLDYTYIPNSIFSLAIELDGFGPHWRDLSRWQFADNLMRQNHLLIDGWKLLRFAYDDVNEKPRICQQTLLMAMSKWGQGKEALVLNVYERAIIQFSLKQSVDLTPKRVSEGLGINIKTAIRNLQSLSKKGFLTPIQSLRGRTMKYVASSQVLSDYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK88</accession>
    <name>A0A398CK88_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_23160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01288">
        <property type="protein sequence ID" value="RIE01288"/>
        <property type="gene ID" value="D3H35_23160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="70"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="277" mass="30706" checksum="F346CD3A2D20755E" modified="2018-12-05" version="1">MAIWKDRLATGAIYAGLILILVITVYPLIWVVGTSLNPGNGLLITRMFPEHPTFQQYSRLIGETDFAQWYFNTLKISFSNMALSTLLIAVSAYAFSRFRFKGRKAGLMILLVLQMFPGFLSIMALFVLLMQTKLLDTHLGLILIYAGGSISFGIWVMKGFFDTIPKSLEEAALIDGANQFDIFVKIMLPLSLPALTFVMMNSFIGPMMDFILPQIVLRSPEKQTLAQGLYNMVSDKMNSGFAQFAAGAVLTALPITIIYTLFQKYLIHGLTAGADKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKD7</accession>
    <name>A0A398CKD7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_17510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03173">
        <property type="protein sequence ID" value="RIE03173"/>
        <property type="gene ID" value="D3H35_17510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="5"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="316" mass="33587" checksum="7012F33B24C89FDB" modified="2018-12-05" version="1">MNGPEVVTFGETMALFMPSSSKGIEHAASLEKLFGGAESNVAIGLARLGHRVGWFGRLGNDPLGRFILKKLRGEGVDVSRAALSANGPTGLMMRESIAGKSSVYYYRKLSAMSAMQPDELDAEYIGSATILHVTGITPALSESCRLTLLEAVRIARSRGVKICFDPNIRLKLWSADEARAALLPIAEQADYFLPGLDELKLLYGTDDLGALSGMLGKLPGVSVIKGGADVTYLLENGRLTEIPYFKAKQVVDTVGAGDAFCAGFLSGVLKRKPLGEAVRLGNLLGSLAVQAYGDWEGLPTSEEVEAVLGGKGHVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKG3</accession>
    <name>A0A398CKG3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02642">
        <property type="protein sequence ID" value="RIE02642"/>
        <property type="gene ID" value="D3H35_18355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="13"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="209" mass="22987" checksum="5D2B0B9747D67D6D" modified="2018-12-05" version="1">MLKFQSFSLGALGTNCYLLVNAERTSAVVIDPGTADTQLLRRLEGLKLEAILLTHAHFDHIGGVEELRRKFSAPVYLHSLEKEWLVDPAKNGSLRWAEVTPPVTGQLPDHLLADGDRLELLGETFVVLHTPGHSPGSVSFLCDDLLFAGDALFRRSVGRTDLPGGNGPQLERSIQTKLYVLDDSILVLPGHGPETTIGEEKRENPYVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKH5</accession>
    <name>A0A398CKH5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_19905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03213">
        <property type="protein sequence ID" value="RIE03213"/>
        <property type="gene ID" value="D3H35_19905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008272">
        <property type="entry name" value="HB-CoA_thioesterase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006684">
        <property type="entry name" value="YbgC/YbaW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003230">
        <property type="entry name" value="YbgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00051">
        <property type="entry name" value="TIGR00051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01328">
        <property type="entry name" value="4HBCOA_THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="3">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="158" mass="17999" checksum="B5AF550DD3DD77DA" modified="2018-12-05" version="1">MKIWSLHPLRVRYQETDRMGVVYHANYLTWFEIGRTEWVRRAGISYLEMEKKGLLLPVTDVEASFGKPAGYDDWVTVCTRVAELSAVRVRFESRIVGGDLTEAANGFTYEGDEPPGAALVRGGTRHVWVKSDSWRPIRLDREAPDWYAALKDLAHTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKM6</accession>
    <name>A0A398CKM6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_19675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02850">
        <property type="protein sequence ID" value="RIE02850"/>
        <property type="gene ID" value="D3H35_19675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="165"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="261" mass="29972" checksum="91B7A2FE14EF5595" modified="2018-12-05" version="1">MLEASPSAFLLKPAFAKIVCEPGWKWQKREKPLANYDLFYVWSGEGEVILNDVPYAVGKGSCFLFRPGDHTSATHNPQKPLVLTYIHFDIAEPVSMVPEPYRALGDTFDFEQLLARYVRLFLVRTFAAEEEARLILKQLVIHLLRHDREEPVEKKASNQLTESIHEIANYIQQHPGVPHRVDDLAARAGLSSRYFSIKFKELIGMSVQTFLIRSRIDRAHHLLIHAGMNVTEVADALGYRDIFFFSRQFKQYTGKSPSEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKU0</accession>
    <name>A0A398CKU0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_24400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01498">
        <property type="protein sequence ID" value="RIE01498"/>
        <property type="gene ID" value="D3H35_24400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="108" mass="12416" checksum="967B5CCA82647B00" modified="2018-12-05" version="1">MKETFIVKHAVGGEIYIDTAKRAVDYRVEPAGAGWTFTVHSPLVPELEEILRMKDELNVFIFREYDDRPTVKTWYYVGDGPVKYDPERGELTIAASSHIEYVPDSYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKV1</accession>
    <name>A0A398CKV1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ring-cleaving dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01839">
        <property type="protein sequence ID" value="RIE01839"/>
        <property type="gene ID" value="D3H35_13700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="153"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="317" mass="35443" checksum="304559B8D7299C16" modified="2018-12-05" version="1">MTTQRTTGIHHITAFARDPQRNVDFYAGVLALRLVKRTINFDAPEVYHLYFGDQAGSPGTIMTFFPWANSRRGTVGGGQVGITTFVVPPGSLEFWRARLASYRIQTRESERFGEQFLQFEDYDGLRLEIVERADGRASQWSFAGVPSDKAIKGFGGAVLYSSAPNRTEAVLTNVMGLDFVGRHAEYNRYRASGDLGNIIDMPANPVGRGNGGSGTVHHIAWRAKDDQDHAEWRSRLQEEGLSPTPVMDRQYFNAIYFREEGGILFEIATDPPGFARDEAQEALGEKLMLPSWYEPHRAEIEANLAPIQVREPEVENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKV9</accession>
    <name>A0A398CKV9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GGDEF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_13750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01849">
        <property type="protein sequence ID" value="RIE01849"/>
        <property type="gene ID" value="D3H35_13750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="254"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="387" mass="42431" checksum="97FE21EC87082645" modified="2018-12-05" version="1">MNSLLDMTTVLISLVIGNLFTLLLVFLYRQKDGIDRSSRTFFAAKVLQSAVWAYYGIFGKALDLFSILFGNTVLFLGIALETSAILMLLGRFTPLMKRFYIGLSAVSIVGFQLVALSGLDEEARTLVASLLFILFVPAPAYLLLSQRKQSLLKGMMGALYAAAVVLLVGRVTAVGIFGINMGLLSPNLFQTVSFLGLYLLMILGNTGFALMSKEKTDGELLRWASLDDLTGVMNRRAFGEAAEKTISGLKKAGQPFSFILFDIDEFKAINDEFGHDAGDRVLQHLTAEIKGRLGSEDLFGRFGGDEFAILLPGQNEERSRGTAERLRSAIESASFEGLPLRYTISLGVVTIEPNKTVQLSQLYKWSDLALYDAKKKGRNQVANNVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL76</accession>
    <name>A0A398CL76_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_20660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03010">
        <property type="protein sequence ID" value="RIE03010"/>
        <property type="gene ID" value="D3H35_20660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="304" mass="35047" checksum="105644DB5BA33A42" modified="2018-12-05" version="1">MEANPQNSFINHVELTGTLLHIPIQPKMTTVPIYNMSFQTIRPKGIIDQLDLVLFGNDQFHKQFKIGDRIRLEGFIQSNNYDKKGYKVEPLHQAAVENYYELFGEYPSDIVPTYNKTSIINWNKLLNAGLVPAIPDDSMYVSQSIKRRGADMKSVYSLNEHRTVTKSTFHINYQVVIQQYRHEDQPPHPLKGDLNRVHMQGKVDQVLYYNPAYGPRKVPFLSLRVFVNAYGVQSFIHVVCWNQLAQSHQSLKKGDIVWLKGYLQSREYDKDVRTTNGKEKQVTAITREVNATDFKLLAQGDSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL99</accession>
    <name>A0A398CL99_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Globin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03195">
        <property type="protein sequence ID" value="RIE03195"/>
        <property type="gene ID" value="D3H35_19030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="124" mass="14121" checksum="A899511AFD39694F" modified="2018-12-05" version="1">MSSYDTIYEAVGGEAVIREIVEKFYPNVQTHPLLAPLFPEDIRPVMEKQYQFLTQFFGGPSLYSDEHGHPMMRARHLPFPITPERAKAWLGCMAKALADTSIPEPLQQLMLERLSGPAYHFVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLD3</accession>
    <name>A0A398CLD3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AhpC/TSA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_12920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01708">
        <property type="protein sequence ID" value="RIE01708"/>
        <property type="gene ID" value="D3H35_12920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="42"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="214" mass="24208" checksum="CE45D1F0BE9C1842" modified="2018-12-05" version="1">MLLHEMLEEAKKQFVAKVPADVHTEIFRLIREQQQAGIVYGLQEGQQAKDFTLNNSAGVPVNLFERLSSGPVVLTFYRGSWCPFCNIQLRAYQAILPEIEALGGQLIALSPQSPDNTLSQQEKEALRFQVLSDTNGLAAGLYHVLFDVPSYIQEVMTNKLKRNLADYNATDRWILPIPSTFIIDKSGIIRSAYVNPDFMQRLEPQDILDQLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLI4</accession>
    <name>A0A398CLI4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HDIG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_06185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04206">
        <property type="protein sequence ID" value="RIE04206"/>
        <property type="gene ID" value="D3H35_06185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011624">
        <property type="entry name" value="Metal-dep_PHydrolase_7TM_extra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011621">
        <property type="entry name" value="Metal-dep_PHydrolase_7TM_intra"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07698">
        <property type="entry name" value="7TM-7TMR_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07697">
        <property type="entry name" value="7TMR-HDED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="HDc" evidence="2">
        <location>
            <begin position="523"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="749" mass="83439" checksum="B0FA4EDE26C9B2BF" modified="2018-12-05" version="1">MSRIVKGPSGKPLALSSAGWKHSAAVRWLLLLLFVLLFYMSISPRLVPETYDLTLNAKSDKDIKAPKQLQDEKATFEAQEAAAEKIGPVYPIVALHNELLVDELFARIDQLNQEDQVTFNEKVDIFKGDIPMRVEKYVTDFVASNKGSQSYSDDLLAEMKRVVTAQSYLVPEETFYKLPKLTSDQLSAMKTVTRDIVRKLTKEPITEAETARTKVAELVNASTLPTKTERETVQELARLTIFPNKFYDKQATDEAKEQARKDAPPVVIKQGDVIVKSGQVITQDIYDQLVALEMLKERKTYWPQVGVLLFCLLFTLALYGYGELTASSAAQKRTNAQWLMLLIVFALNLLFMHLAALAHSEQWPYVGLLAPVALGSMLVTLLIDMHLGMVSALLFSLLASIVLNVEQKQVFDFHYGFVTAVVSFTAVLAIYRASQRSSILKAGIMVSLFGSIAVLALMLVDQEPDKTQIVQSIGFIFSSGLLTAVLVIGLMPFFELTFGILSALKLVELSNPNHPLLRKLLTETPGTYHHSLMVGNLSEAAAEAVGANGLLCRVGSFYHDVGKTKRPLYFIENQNGGENPHDKLEPKVSASIIIAHARDGADMLKAYKLPKQIRDIAEQHHGTTFLKYFFHKVVKQAEAQGVECAYSEDDFRYPGPKAQSKEAAIVGIADCVEAAVRSLNHPTVAQIEGIIGKIIKDRLDDHQYNECDLTLRELDKIAETLKETVIGMFHSRIEYPDDKEMKKLKEKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLJ8</accession>
    <name>A0A398CLJ8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rfbD</name>
        <name evidence="4" type="ORF">D3H35_15115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02089">
        <property type="protein sequence ID" value="RIE02089"/>
        <property type="gene ID" value="D3H35_15115"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="278" mass="30662" checksum="831D21DDA96737ED" modified="2018-12-05" version="1">MKVVVTGGSGQLGKEVMLVLQGKHEVYGLGRQELNVADPQQCKEVLDRIRPQAIIHCAAYTAVDKAETDSEQAYLVNATGTKHIAAAAESIGAKLCYISTDYVFDGEGTAPYRVSAPTQPRSVYGQSKLLGEHYARKLCTKAFVVRTSWVYGLHGANFVKTMLKLGQEKDSLKVVNDQIGSPTYTRDLAMFLLELIESDRYGVYHASNSGSCSWYEFASAIFEEAGINVQVEPCSTAEFPRPAPRPKYSVMDLSDLGSNGFQPMRPWREALRCFLQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLT5</accession>
    <name>A0A398CLT5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000035">
        <property type="protein sequence ID" value="RIE03613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03613">
        <property type="protein sequence ID" value="RIE03613"/>
        <property type="gene ID" value="D3H35_10765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="277" mass="30527" checksum="E1CD8B3E6D2EFE8F" modified="2018-12-05" version="1">MDLSQPMTTWRTIVVSLEPFDTARQAVSSAGLETIVPPPVIVPPLTTGFTKWTYQRIFLSPGRGISGRLTLRAAPHPPSRPQAVTASTELSSRSGAAFVRLKLSPLEPLAYTCSTFIVTEDSRGIRQWDGLELARTEERLRLKPDDFPIRFVPIAVSPELLELATIRGRCEWLEANHSSASSAFVLDRDRPELAIAIPAAASNASFDFDVLSVEGDRSLHLGPFSAEPLLLGLHLFPEYGPQQISIELAEAASPSLVAIDLLPENRKRWPKPLPYWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLT6</accession>
    <name>A0A398CLT6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03220">
        <property type="protein sequence ID" value="RIE03220"/>
        <property type="gene ID" value="D3H35_20210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="45"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="292" mass="32740" checksum="9C4B2A924C7B4960" modified="2018-12-05" version="1">MPRGSATATVASDALVELQLLTAGFCRHPEFLTLRGGALKPVPFPAGFAVIRHPRHGYILFDTGYSARFFDETKRFPALLYRMMTPVTFSEKDSAVNQLRRQGIEAEDIRYVVLSHFHADHVAGIRDFPHASFLYKKEAYAAVKNLGSFASVKAGYLPGLLPENFEKRSLFIEEANRCRLPNDFPFLTGYDLLGDGSLIAVDVPGHAAGQIGLFLSTASSDYFLCADAVWSSRAFQERRKPHAAARLIMADHRHYADTFERLCLLHRQYPHIRIIPSHCGEALLQRTGEEQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM11</accession>
    <name>A0A398CM11_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellar hook-basal body complex protein FliE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">fliE</name>
        <name evidence="4" type="ORF">D3H35_11360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the FliE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03282">
        <property type="protein sequence ID" value="RIE03282"/>
        <property type="gene ID" value="D3H35_11360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00724">
        <property type="entry name" value="FliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001624">
        <property type="entry name" value="FliE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34653">
        <property type="entry name" value="PTHR34653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02049">
        <property type="entry name" value="FliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01006">
        <property type="entry name" value="FLGHOOKFLIE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00205">
        <property type="entry name" value="fliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="102" mass="11064" checksum="8913FC46FF33EC16" modified="2018-12-05" version="1">MITNNLIAPVGITTNVLTPLERKTATPAEATESFAAFLKNALDGVAAQETNVHKVTDQFIIGNADVNDVMIAATQAELSLSLTSQVRNKVIEAYQEIMRMQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM22</accession>
    <name>A0A398CM22_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpe</name>
        <name evidence="15" type="ORF">D3H35_07370</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04396">
        <property type="protein sequence ID" value="RIE04396"/>
        <property type="gene ID" value="D3H35_07370"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="143"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="177"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="14">
        <location>
            <begin position="199"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE04396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="223" mass="24411" checksum="90EB7573B0BC1F55" modified="2018-12-05" version="1">MEKAYYRPSILASDFSRLGEEIRSIEEAGADWIHIDIMDNHFVPNLTFGPPIVSMIRHVTKLPFDVHLMVERPETLFPALAEAGADRITVHPEACVHLHRTLASIRELGIKAGVALNPHTPLNVLEYMLDEIDLVLIMTINPGFGGQAFLPSMLPKLRQLRELLDKHGRNDIHIQVDGGINAETAALVTDAGANSLVAGTFIFGKQDRAAAISALRAASKVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM44</accession>
    <name>A0A398CM44_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ROK family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_16325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional repressor of xylose-utilizing enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02289">
        <property type="protein sequence ID" value="RIE02289"/>
        <property type="gene ID" value="D3H35_16325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="386" mass="41156" checksum="285E07F677D75A25" modified="2018-12-05" version="1">MTTITGDQALIKRINTAVVLEAILRAAPLSRAQISESTGLNKATVSSLVQDLIDNSLVREIGRGESSGGRKPVMLEFIASSGYSIGIDLGVNYIRGVLTDLRGSVIAERTASLRQVEPEPVLLALFRCIDDLIAAAPDSRYGIVGIGVGVPGLVDESGTVLYAPNLKWREVALRKMVAERYAVPVTIDNEANCGALGERKYGAGRRIGNLVYVSVGIGIGTGLILQKELYKGASGFSGEMGHLSVEAFGKPCGCGNRGCWEMYASEQALLSKASELGLNDLESLLASAEGGREDVRALFGEVGEYLGVGIANIVNVFNPDAVIIGNRMNKARPWIEDHIRSTVVQRALGFHLRKVQLLFAELGERSAMMGAAEMATAGFFIQLKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMH7</accession>
    <name>A0A398CMH7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA polymerase sigma factor SigI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">sigI</name>
        <name evidence="3" type="ORF">D3H35_10220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Negatively regulated by the anti-sigma-I factor RsgI.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with RsgI.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. SigI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03665">
        <property type="protein sequence ID" value="RIE03665"/>
        <property type="gene ID" value="D3H35_10220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02064">
        <property type="entry name" value="Sigma70_SigI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014244">
        <property type="entry name" value="RNA_pol_sigma-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30385:SF6">
        <property type="entry name" value="PTHR30385:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038953">
        <property type="entry name" value="SigI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02895">
        <property type="entry name" value="spore_sigI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="42"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Polymerase core binding" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="264" mass="29690" checksum="9BC10683F5609DF4" modified="2018-12-05" version="1">MLLLLWRKWFPLEEDGVRKDDGSPESMVAAIQAGDDGLRNELIAKYKPYIAKTASRFSRRFIDPERDDEFSVALAAFNEAISSFSPDGGRRFLGFSEKVITRRLIDYARQEGRHSASIPYSAVAGNGSEGADKLDKVEAVQALEVYEQQREAEERRTEIVALQQQLDAYGIGFPELTEQSPRHADSRRALLKLAGLLAQSDPLFEKLADKKQLPVKELCETGNVSRKTVERHRKYIITVALIARGPFPFLKEYIGMNRGGEEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMK9</accession>
    <name>A0A398CMK9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_10375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03695">
        <property type="protein sequence ID" value="RIE03695"/>
        <property type="gene ID" value="D3H35_10375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017245085" evidence="2">
        <location>
            <begin position="33"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="603" mass="66222" checksum="16AC38CEFFBD6130" modified="2018-12-05" version="1">MWEGEVPLKSRKRLAVLVSVALCLTLVVAACSKDNEGKNDPKQSPSQTAQPTASAESSPSSDGSQGFAFHKYDPPIKLTFHTAVSADTKWRDGESVDNNAFTQWAKDELGIEWKTKFVTPTNEDGKTKINLGMASGDLPDAIFGETPQLSTLASQGYLLPLNDLIDKYASPLVKDRLEAAMDASGGKFLSPYTIDGKYYALPIDAEIWGRTYYNTFIRQDILDTLGKPVPQTLDQFEDVLAAYKAQVPDGVGVFLHKDLVPNGVNQMSPAMQPYGAYPGRWIVGADGKLAYGSVQPETKKGLETLRKWYSNGWIDKEFIVKDFSKAVEQVATGKTLSMTGDWWFVYYPFPDVVKNVPQATFSATSLLGPDGKAKLVTGNPFNFAIGISAESEHPEAFIYQLNELMDSALRQDTALRDRLLGESGYIFKYPAESPSALVAKNPEAPQELQDFDVAKPGPKFFRTSVHPKYYPGFSFFGEVDTGYSDLVAVANAAETGNKDGLTAAQLQSYTDLSNNKVLSALVSEMKLAKSIRSDLTIDAFMGAPTPTMIEKNAYLLKLENETFSKIIIGTAPLDDFDKFVAEWNKAGGAQITKEVNDWYEKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMQ1</accession>
    <name>A0A398CMQ1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="7">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tyrS</name>
        <name evidence="10" type="ORF">D3H35_12100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03520">
        <property type="protein sequence ID" value="RIE03520"/>
        <property type="gene ID" value="D3H35_12100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="9">
        <location>
            <begin position="353"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="229"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="419" mass="46978" checksum="E6B4295C01B5CA7F" modified="2018-12-05" version="1">MTFIEDLEYRGLIYQLTDREGLLEKLQNERVKLYSGFDPTADSLHIGHLLPVLCLRRFQLAGHLPIALVGGGTGLIGDPSGRSTERSLNTSDTVAQWTERLKEQLSSFLDFETDVNPAVMASNYDWLAPLDVITFLRDIGKNFTVNYMLAKDSVNSRMESGISFTEFSYMILQSYDFFKLNKDFGCSLQIGGSDQWGNITAGLDLIGKMGGTKSFGFTMPLVTKSDGKKFGKSESGAVWLDRNKTSAYQFYQFWLNTDDNDVIKFLKYFTFLTREQIEELEAELRERPEQRAAQRTLAREVTGLVHGQEAVVSAEKISQALFSGDVKLLSESELVEALDGVPSVLLEDGEPLPLLDFVIAAGAAPSKRQAKQDIESGAVYINGERLKEAELAVSSDYRLHGKYVVLRRGKKNYFLVQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMX2</accession>
    <name>A0A398CMX2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Energy-coupling factor transporter transmembrane protein EcfT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_22990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01257">
        <property type="protein sequence ID" value="RIE01257"/>
        <property type="gene ID" value="D3H35_22990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="297" mass="33444" checksum="B278D47E119F34C0" modified="2018-12-05" version="1">MNEGFGVRSLHPSVVLLYYAGGITFGMLLFHPLLLIAGWAALLLLNLHLDQGKEWRRWAIPMTTGLLFLIVLNPLISHRGRTVLYYWGDIPITLESVAYGATLAASMLNLLTLFVSYRVLMTEHKFLYLFARLSPKAALLVMMATGLVPRLVRRLQELTLIQRTRGVSVKEGSFRQRAHNGVRLVGTLLSWSLEDALQTADSMQARGYGTGARSSYLDFRFRKRDAVALGLLAAVALAVMAAWWNGHGFWTIYPRLEPFGLSSGDAAALVFYLIYLLLPLGWEWRDRYAWRGWNAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMX7</accession>
    <name>A0A398CMX7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Thymidine diphospho-4-keto-rhamnose 3,5-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rfbC</name>
        <name evidence="5" type="ORF">D3H35_09740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:16969"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="5.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03825">
        <property type="protein sequence ID" value="RIE03825"/>
        <property type="gene ID" value="D3H35_09740"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01221">
        <property type="entry name" value="rmlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="192" mass="21344" checksum="FB9BC0D3B0229A19" modified="2018-12-05" version="1">MKLITTELDGVWIIEPQVHVDNRGFFMESYNDAFVRGLGIPSAFVQDNHSLSKEAGTLRGLHFQSAPRAQTKLVRAASGAIYDVAVDIRPRSATFGRWVGVILSADNRRQLLIPQGFAHGFCTLVPNTEVLYKVDDYYSREHDGGVAWDDPDLGIPWPFAQPVLSEKDGRHPRLRDLSPNANTEADKEADAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN83</accession>
    <name>A0A398CN83_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_04930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKC lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04816">
        <property type="protein sequence ID" value="RIE04816"/>
        <property type="gene ID" value="D3H35_04930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008844">
        <property type="entry name" value="Spore_GerAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038501">
        <property type="entry name" value="Spore_GerAC_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35789">
        <property type="entry name" value="PTHR35789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05504">
        <property type="entry name" value="Spore_GerAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017281451" evidence="4">
        <location>
            <begin position="27"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="382" mass="43295" checksum="2CA5A74220F6202F" modified="2018-12-05" version="1">MREKLRRILLSGVCLVILSTMLSACWDEVTIQDVNYVTALGVDYDAQSEQFTLYVQLIDMSTVAKSEANSATSNAPASFTGIAKGHTVYLAMQDLLNTIQEPPSLEQLMAVIVNERALSQMSDILDALNRNRAVRYTTQLTATDIDIPELFNADRYFNKSPLMNVYYNPGYNVEKRPHSPIADVQHFVREYRNPTLTALIPRMVMSDKHWLAEGKPARFPYVEGAYAFKKGKWIGEIKDEEIRGMKWFKASMLQSTIPIMKDGSYAASLSVISNKGQIKYVPGVNGGSYVFTLNVQSVVKEQMEKLGMRQMMQLAEKAVKDDLQRSIQYSAKKGIDLYNVEEQAYRYHHKSWVKAKAEGIEFERLPVKMIVNVKIMSTGKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNC5</accession>
    <name>A0A398CNC5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tmk</name>
        <name evidence="5" type="ORF">D3H35_23910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01417">
        <property type="protein sequence ID" value="RIE01417"/>
        <property type="gene ID" value="D3H35_23910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="4">
        <location>
            <begin position="12"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="13"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="210" mass="23529" checksum="755C9FDF890F30E9" modified="2018-12-05" version="1">MTVRGGLFITMEGGEGAGKTTLISLLEGKLGQIGRETVITREPGGIPIAEAIREVILNKDNTAMDARTEALLYAAARRQHLVEKVMPALNRGAVVLCDRFVDSSLAYQGHARGLGVEDVWNINRFATEGCMPDLTLYLDIDPEDGLRRIKANEEREVNRLDLESLDFHRRVQEGYRIVAAKFPERFLSLDASLDPQELLDRAWRLLQNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CND7</accession>
    <name>A0A398CND7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF370 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01427">
        <property type="protein sequence ID" value="RIE01427"/>
        <property type="gene ID" value="D3H35_23975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007169">
        <property type="entry name" value="RemA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04025">
        <property type="entry name" value="DUF370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="81" mass="9172" checksum="BEEC3C6F299092B4" modified="2018-12-05" version="1">MYIHLGGEKIIRTSQLVAIFDISIEQSSKLSRQFVAQAQKNRVVETIGEEDPKSIVVTEERVYYSPISTSTLKKRAHHLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP24</accession>
    <name>A0A398CP24_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YtxH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_20835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03039">
        <property type="protein sequence ID" value="RIE03039"/>
        <property type="gene ID" value="D3H35_20835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024623">
        <property type="entry name" value="YtxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12732">
        <property type="entry name" value="YtxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="115" mass="12042" checksum="0FF599BFD495AF43" modified="2018-12-05" version="1">MADKKVVKTFLWGALTGAVSGAITALLFAPKSGKELRKDIADTAQKVGGKTADLSRQAGSSVQSLARRTSEFASDAKQAASRFVTDIRSRRGSEAAVEEAAASSEASPDEERQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP43</accession>
    <name>A0A398CP43_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-layer homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00684">
        <property type="protein sequence ID" value="RIE00684"/>
        <property type="gene ID" value="D3H35_27385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="156"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="281" mass="30262" checksum="25306239507DED58" modified="2018-12-05" version="1">MLPISSCRSIPANCFKGSFWSFIPETLRCLLTPALLEQLKNGLSDSQQQEGKLQVKVELQALSGAGVKPGAGVALQGAVIDFDIQAIAKDGQTSSSSGFEQPVKVRWPVSSAYDSDLLGIYKISDSGEPIYVGGTVVNGAIEAELNEAGKYALLEYRKTFSDVPATHWAANTLTRIAAKHLIAGTSETTFEPNRSITRAEFVKLIVNTLPLTDKADLAFGDVPENAWYADSLAKAVEAGLVSGKSADRFEPNAVITRQEIFDDSDARLRHRASDGISVRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPB8</accession>
    <name>A0A398CPB8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02558">
        <property type="protein sequence ID" value="RIE02558"/>
        <property type="gene ID" value="D3H35_17885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="79" mass="9262" checksum="9A54FC57FDFE536D" modified="2018-12-05" version="1">MARFLCRCGEILSNSEVPSGIELRVYTDREWEQIASSDSVDPLLIPFPKYEVWRCPKCERIYVFEEGNQSAIKVYKLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPJ8</accession>
    <name>A0A398CPJ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02638">
        <property type="protein sequence ID" value="RIE02638"/>
        <property type="gene ID" value="D3H35_18325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="230" mass="25737" checksum="6DE19DEDC2F118CA" modified="2018-12-05" version="1">MVRIGQGMSEEKVLLPLAALLHCRTVVEKQNFVSTGLMTHVEGELFEVELAEFDLFNLGETVKLTVYSPVGIQTIQSIVFAKYDGAIALIQPPAIRKRFEEKREHPRVEISGSLSISHIRESGVERVLEQPLIVPLRNISISGIGFEAPETHDISKGAVMKGIVDAGLVFACGLELKRRDRVEDIYIFGAIMTLEEPDMLRSLRAFVLKRQVENHVESRKRAGKQRSFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPR5</accession>
    <name>A0A398CPR5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_18950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02728">
        <property type="protein sequence ID" value="RIE02728"/>
        <property type="gene ID" value="D3H35_18950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="199"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="300" mass="34038" checksum="0CC7D75A5547EFBA" modified="2018-12-05" version="1">MDYITYGDAMYTGHPHPMKYVPETSALEDGQPSFCYRLIFVQAGNGLLSINDKLYPITAPALYGLNEKEAAKFHAAGAPVAAVSLRFHPSVVNDKLTLDLEAGPGADYIVTDVQDRWLLKPFFERLDGYYGCIPVDPSMIKLITQIMDDIRETLTVQPVSWPCKSRSLLMELLLLMKRMNPLTSDAPDTIAGMAEDPVLPIVEYLHSFYEQKLNIEELAKTFHTNKTTLNKRFRVYTGHSVMSYLNAIRMRKASDYLRTTTDPVQVILERTGFKDATHFARNFRAYSGYTPSEYRNRSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPU4</accession>
    <name>A0A398CPU4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_00450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000005">
        <property type="protein sequence ID" value="RIE05436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05436">
        <property type="protein sequence ID" value="RIE05436"/>
        <property type="gene ID" value="D3H35_00450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="77" mass="8725" checksum="1E73A3AC645AFB4E" modified="2018-12-05" version="1">MRSKGLNFTFSGSLKSLMLFIAFGLIVIVNIVPILWGLKTSIMSPSDIFSYPPKLFNFEASFEHYIESLTEGIFKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ34</accession>
    <name>A0A398CQ34_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_12130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyltransferase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03409">
        <property type="protein sequence ID" value="RIE03409"/>
        <property type="gene ID" value="D3H35_12130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="4">
        <location>
            <begin position="13"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="660" mass="70998" checksum="70A1F9C4FFA59559" modified="2018-12-05" version="1">MKNNEHGNRRYMPGLDGLRTLAVFAVIAYHLDLRWATGGLLGVGAFFVLSGYLITDLLVEERQRNNRIDLKMFWIRRARRLLPAMLFMMLVVVAVLSITDSGRLASIKGDLLSALTYSSNWYLIFHDVSYFESFGPPSPIGHLWSLAVEEQFYLLWPLLLTGILMLVPSRGKVAMIILAGAALSFASMAILYEPGSDPSRVYYGTDTRAFGLLIGAALAIVWPSGKLAGAFSRKGALIIDSLGAAGLACTVYMLAATGEYDESLYKGGMVVLSVAVAFVIAAVASPYSLIGKLLGCKPLRWLGVRSYGIYLWHYPVIVMTGPAVPTGEPDAVRALLQVAASVALAAFSYKYVEEPIRRGRWKPWKAILRKKDRLGSGRLRLLRQRSTKMLTVSLIVMICISCTNGNNGHPSVSADSGKQPAVSDDSSASPEASGPVDVPDTTNPTVPAFPAPSAAQAEPAPSPKPSPSKDSPGPSPTAKPVVKPPKPMPDSSDSKPSPGAEKPVEGAGGITAIGDSVLLDAEPYLKKLVQGILIDGKVGRQMSKAQEVVDGLLAEKKLGNLVIIELGTNGSFTAKQMNKLIDTIGKDRRIVLVNTRVPRKWQDTVNSALSKAAAEHDNVTLIDWYAFSADKAEWFAKDGVHLKLKGAEAYAKLVADSLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQC2</accession>
    <name>A0A398CQC2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diaminobutyrate--2-oxoglutarate transaminase</fullName>
            <ecNumber evidence="5">2.6.1.76</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Diaminobutyrate--2-oxoglutarate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-2,4-diaminobutyric acid transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_22555</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + L-2,4-diaminobutanoate = L-aspartate 4-semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11160"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58761"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="2.6.1.76"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amine and polyamine biosynthesis; ectoine biosynthesis; L-ectoine from L-aspartate 4-semialdehyde: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.76" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01184">
        <property type="protein sequence ID" value="RIE01184"/>
        <property type="gene ID" value="D3H35_22555"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00067">
        <property type="reaction ID" value="UER00121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045303">
        <property type="term" value="F:diaminobutyrate-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019491">
        <property type="term" value="P:ectoine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004637">
        <property type="entry name" value="Dat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43552">
        <property type="entry name" value="PTHR43552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00709">
        <property type="entry name" value="dat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE01184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="453" mass="49387" checksum="D2A3DA2A2E801E9A" modified="2018-12-05" version="1">MMISINAENTYLQLQNDRESNAKSYPRRFPLVIDKAKGLIITDTEGKSYYDCLSGAGTLALGHNHDVIIAAIGDVLEKQIPLHTLDLATPLKIAFMEEIFSILPEGLRDTAKIQFCGPTGADGVEAAIKLVKNATNGKSILAFQGAYHGSTQATMSMSGNLSKKQHLQSLLPDVHFLPFPYEYRCPFGVGKGMTAKISTQYIENLLDDCESGIASPCGVIIETVQGEGGAIPADIEWLRELRRITAERGIPLIVDEVQTGIGRTGTMFSFEHAGIVPDVIICSKAIGGSLPMSVVIYKEELDQWKPGAHTGTFRGNQLGMATGLATLKYMKEHRVLDNVKARSEQFFEALNRLKATYEEIGDVRGRGLMIGVEVVDPNGQKDRIGHYPPCGELASKIQESCFKNGLIIEVGGRRSAVLRFLPPLTITAQETAEVLSIFEKSVASAIEAKRYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQC7</accession>
    <name>A0A398CQC7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_25150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01631">
        <property type="protein sequence ID" value="RIE01631"/>
        <property type="gene ID" value="D3H35_25150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="66"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="270" mass="30631" checksum="DB34DB232FBA840C" modified="2018-12-05" version="1">MRKLISTIVMFMFALLMIYPFLWMISTSFKQPFEVFQYPFQWISDHPTLKYHENVWTGPASFIKYYLNSLKISTISTIGAVFFAAVAAYGFSRIEFKGRDTLFLIYLVAMMVPNQIIFVPKFILFNAIGIYNTHLALILPGIFTVLGVFMLRQFFIAVPKDISESAMLDGAGHMRIFLRIMLPMAKPSLATLAIIDFSWHWNDFENALIFLLDEKLYTVSLGLQNFVLENSVDYNGMMAAATAGMLPMIIVFLIGQKFIVEGLASSAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQF8</accession>
    <name>A0A398CQF8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_04605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04763">
        <property type="protein sequence ID" value="RIE04763"/>
        <property type="gene ID" value="D3H35_04605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="103"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="330" mass="36348" checksum="0D507ACDF51B3344" modified="2018-12-05" version="1">MNARAGSSGIREPAAAALRPSRQINIVLRKADSAADAAQGLADSAAAASGVKAMPQTGPWSDWHKELDKMVGLENVKDLVYEIYALLQISQFRSEAGLHAHAHVYHMIFKGNPGTGKTTVARLLAKLFQNMGLLTKGHLVEVERADLVGEYIGHTAQKTRELVKKALGGVLFVDEAYSLARGGEKDFGKEAIDTLVKAMEDYKNQFVLILAGYTMEIDAFLLTNPGLPSRFPIAMEFPDYTADQLIQIAEGMAKDRDYSLLPQSLFKLRDLILQEKTESIYPFSNARYVRNVIERAIRNQAVRLLAVYPTGASPGRQELMALRAEDIKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQJ0</accession>
    <name>A0A398CQJ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster biosynthesis family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04752">
        <property type="protein sequence ID" value="RIE04752"/>
        <property type="gene ID" value="D3H35_04525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="1">
        <location>
            <begin position="17"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="122" mass="13658" checksum="DDE864D0294F9FDD" modified="2018-12-05" version="1">MYNQPKPTKDIGVIGLKISWSPEASDELLRRYGDDAVEWRLVYDTEGCGCAVNGVPALWAVTGPEPDDSAADSTPFKLWHDPRQAVFFDDELRVSFNSEKMSFSLASDGQIYTSRLVLADRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQK0</accession>
    <name>A0A398CQK0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="5">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hisC</name>
        <name evidence="7" type="ORF">D3H35_04985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04825">
        <property type="protein sequence ID" value="RIE04825"/>
        <property type="gene ID" value="D3H35_04985"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 5 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="6">
        <location>
            <begin position="26"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="352" mass="38994" checksum="57EBEA6CDD6F2343" modified="2018-12-05" version="1">MSRYWNERTASLVPYVPGEQPKDQTYIKLNTNENPYPPSPAVLEAIRSATGDQLRLYPDPTCEDLTRAIAIRYGVSEKEVFVGNGSDEILAFAFAGFFTPGSPILFPDITYSFYPVYAQLYGLDYETIALDESFGVPIEDFRRPNGGIVLPNPNAPTAQAIPLAQIRKLLDSSPDRVVVIDEAYIDFGGESAIGLVGQYPNLLVVQTLSKSRSLAGLRVGFAIGSEELIEGLNRIKNSFNSYTIDRLALAGAIAAIEDNDYFETTRQAVIATRERTVRQLVRLGFNVTDSKANFVFVAHPEKNAADLFAQLKRDGILVRYFNKPRIDNYLRVSIGTDEEMDAFLAAIEKIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQS1</accession>
    <name>A0A398CQS1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000034">
        <property type="protein sequence ID" value="RIE03619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03619">
        <property type="protein sequence ID" value="RIE03619"/>
        <property type="gene ID" value="D3H35_10615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="457" mass="51342" checksum="A9C735D70CBBB999" modified="2018-12-05" version="1">MLGDTARTIDNYTPYMARKKAIVEERIESFKAKLEKHFDWNWDNIFSSLGSIAFAPTSSVMWITHGAKIAFDGKTKVTGADDDTINEAYLVNRLKTITKDFQSLKEGYSAMPGGSLQPDDPGAAKLVGDAEAIESLLRQVSDQIDSTELREALHDYVQTVIDRNGHIMTYNATAVLLLQTINEQQELESAIKRFNQQMIGMMTEVSPEHTGFVARMYFDAIAQIFEMLYLTTRAYNFWALEHIQLSDVLGGSVKEVTYAGLLSAQNRILGLYKDAVGHFGTNCSYFPANQQKGISFKLTPLQLGFMKTNYEAMVNIPLQKHEADAKSPFAGLANVRITKVRCFLNGAKVKPGAPNSEVLLNITHSGQEQLISRDNAIYDFHHDKREVPFRYDLNDATIVIDGSFGESLQGEKTPYALFGPYTTWKIEVDKSFRSRIDLSELEEVTLEFHGTCYSFHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQT0</accession>
    <name>A0A398CQT0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01781">
        <property type="protein sequence ID" value="RIE01781"/>
        <property type="gene ID" value="D3H35_13345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016919">
        <property type="entry name" value="UCP029416_PTP"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029416">
        <property type="entry name" value="UCP029416_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="112" mass="13192" checksum="30667AD455D3C0FF" modified="2018-12-05" version="1">MKLLFVCSRNKWRSLTAEKIFNGYNGYEVRSAGTEENARIKVTEGHIGWSDLIFVMEKKHTRRLREKFSDKLRGKQIVCLDIPDDYKFMDEDLIEILKSRVSDYIEVPEESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQT6</accession>
    <name>A0A398CQT6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ChbG/HpnK family deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_05255</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04872">
        <property type="protein sequence ID" value="RIE04872"/>
        <property type="gene ID" value="D3H35_05255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006879">
        <property type="entry name" value="YdjC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31609">
        <property type="entry name" value="PTHR31609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04794">
        <property type="entry name" value="YdjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="299" mass="34083" checksum="5A36E4B1C7FA06E7" modified="2018-12-05" version="1">MIQELGFSPTDRVVIINADDLGVTRSTNQAIMQMFQNNAITSTSIMVPADAALDAALQCTKGKAMNVGIHITLTSHKSRFYKPINNLKKFSSLTNEHGYFYDEVCDFEKNADLDEVRIEVEAQIQTAISLGIEPTHLDSHAGSILGLYNNRDFLEVIFYLCQKYALPFCLPIRILEHPSFSSEQKQMFRQRIHLANQLGVRLIDDIAGLTYHFSSDEGYEGAKKELIKQINNLKPGITQITTHPAIVSDELKELTKFYENREIEYQLFNDPDVKELIKNQNIKLISWKAIRDLQRNSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQX5</accession>
    <name>A0A398CQX5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DinB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01831">
        <property type="protein sequence ID" value="RIE01831"/>
        <property type="gene ID" value="D3H35_13650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="21"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="183" mass="20705" checksum="2A50960080ABACB6" modified="2018-12-05" version="1">MIMISHIETVTSLGQLTDLYADELKAYSMEQLTRKPSEDEWSLGQMYVHLINTALNMQLRNVEICRDRSGESVTETKGATEAGQAIFAAGGFPPVRIQVPPSPQYTPGQPESKEQLAEGLQTVLRRMKEISSELESIDPRQTVDHPRLGAFNANQWFALVEMHFRHHLLQKKRLQDWLSSSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR13</accession>
    <name>A0A398CR13_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_03225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04962">
        <property type="protein sequence ID" value="RIE04962"/>
        <property type="gene ID" value="D3H35_03225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="958"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2468"/>
            <end position="2542"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="993"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="2664" mass="298569" checksum="4BEFD4BA8FC5F5B8" modified="2018-12-05" version="1">MSTNIEIEDIYPLSPLQQGMFFHSFINQDSNSYRSQMFMEFKGDFDVDLFEKSVNKIIERHQIFRTIFNNQNKDNKLLQIVIEERPTKVFFEDISALGVLEQDKLFSHFKEKDLIAKFDLFKDHLVRFYLFKTGDQSFRSIWSFHHILLDGWSVSTVASELIAIYQSLRVQKPHGLGPVTPYSQYIKWLGKQDRAAASQYWEGYLEGYELSVTLPTLGNQQSEAYMLEKMSLTLEEDLTRRLTRTANEHQVTVNTWLQTIWGVLLQTYNGVDDAVFGSVVSGRPSEIAGIEQMIGLFINTIPVRIQSRPGMTFSDLVKQVQRSSLSSAEYDYYPLYEIQASSPLKQGLVNHVMVFENYPIGEAIEQSSGQSIGFAISNVETFEQTNYDFSIMILPGKKMTIEFSYNAARIDRGMVARIRGHLQEVIGQVVETPHVGIDQLEIVTEEEKRQLLHAFNDTKASYPADQTIHGLFEEQVKKTPDHTAVVLESESLTYAELNGRANQLARVLRGKGVGADRIVGILAERSLEMIVGILGILKAGGAYLPIDPDYPAERIGYMLEDSGADILLTQKRLQGQTIGFAGEVLPVDDERLYALDDTDLDHTGSSKDLAYVIYTSGSTGKPKGVIVEHRSLVNLCEWHRNEFKITASDRSTQYAPSVFDASVWELFPYLISGSEVHLLDDVIRLDVNELNRYYHENDITITWMPPQVYEQFAALENRSLRILLTGADKVKGYQLNNYEVRNTYGPTESTVICTHYAISHNAANIPIGTPIANTKVHIVDAGGRLLQPIGIPGELCISGAGLARGYLNQPELTAEKFVANPFAPGERMYRTGDLARWLPDGNIEYLGRIDEQVKIRGHRIELGEVESALRSHESVKEATVIARKDEEGSAYLCAYFVANGNLGAAELRKHLSEMLPQYMIPSFFVRVEQMPLTPNGKLDRKALPSPEGTLERGTVYEAPRNALEETLANIWQGVLGVSAIGIADNFFELGGDSIKAIQISARLHAHHLKMEIKDLFQHPTIGELSSCLRPVGRTIDQGLVEGEVELTPIQRWFFEQNFTDRQHCNQAVMLHRKDGFDERIVREVLAKLAEHHDGLRMVYHPGSEGYTQRNRGMEGEVFHLEVRDVTGDQQAEEEVIQACATEIQASMDLGKGPLLKAGLFKTAEGDHLLLAVHHLVVDGISWRIVLEDLNTGYRQAMNGEAIRFPAKTDSYQAWAKALQGYANSGQVLEEAEYWQAVERVEVKPLRKDSEVGAGLMKDGRHVSLTLTEEQTEKLLKQVNKAYNTEINDILLTALGLAIGEWNDSKQAAIELEGHGREEIGHEVDISRTVGWFTTQYPVILEMEQSRELSYQIKTVKEHLRRIPNKGIGYGVLKYGKAAAEGRTWKLKPEVSFNYLGQFDQDVETGLFAGSRYGAGSSVSPNGERTSTLSINGMVLGGQLQLTIDYNGKAYEADTIEKLAAGYKRHLEAIIEHCADRRETEKTPSDLLFNELSIEALDQIHEAFMHVGKVDNIYPLAPLQQGMLFHHVFDPGSHAYFEQTSFEIDGYLDVGLFEKSINTLIERYDIFRTVFHYGEGNRLLQMVLRERPIQIQLADLAEYGIEEQNGVIEQFKQKDKAQGFDLSEGPLMRLALFRKGTAGYTMVWSFHHILMDGWCLSVVAKELFAIYQSLREQKPHGLGPVTPYSQYIKWLGKQDRAAASQYWEGYLEGYELSVTLPTLGNQQSEAYMLEKMSLTLEEDLTRRLTRTANEHQVTVNTWLQTIWGVLLQTYNGVDDAVFGSVVSGRPSEIAGIEQMIGLFINTIPVRIQSRPGMTFSDLVKQVQRSSLSSAEYDYYPLYEIQASSPLKQGLVNHVMVFENYPIGEAIEQSSGQSIGFAISNVETFEQTNYDFSIMILPGKKMTIEFSYNAARIDRGMVARIRGHLQEVIGQVVETPHVGIDQLEIVTEEEKRQLLHAFNDTKASYPADQTIHGLFEEQVKKTPDHTAVVLESESLTYAELNGRANQLARVLRGKGVGADRIVGILAERSLEMIVGILGILKAGGAYLPIDPDYPAERIGYMLEDSGADILLTQKRLEAQTMGFAGEVLHVDDERLYALDDTDLAHTGSSKDLAYVIYTSGSTGKPKGVMIEQDGVINALLWRKQAYGFNETHSVLQLFSYSFDGFVTSFFTPILSGARAILLQDTRNPYAIVKAIATSKVSHFICVPSLFQAIQEYLSPQDAEHLQVITLAGEKADSGVIEKTVGRYGHIEIVNEYGPTENSVVTSYLRHVERALKLTIGSPIANTKVHIVDAGGRLLQPIGVPGELCISGAGLARGYLNQPELTAEKFVANPFAPGERMYRTGDLARWLPDGNIEYLGRIDEQVKVRGHRIELGEVESALRSHESVKEATVIARKDEEGSAYLCAYFVANGNLGAAELRKRLSEMLPQYMIPSFFVRVEQMPLTPNGKLDRKALPSPEGTLERGTVYEAPRNALEETLANIWQGVLGVSAIGIADNFFELGGDSIKAIQISARLHAHHLKMEIKDLFQHPTIGELSSCLRPVGRTIDQGLVEGEVELTPIQRWFFEQNFTDRQHCNQAVMLHRKDGFDERIVREVLAKLAEHHDGLRMVYHPGSEGYTQRNRGMEGEVFHLEVRDVTGDQQAEEEVIQACATEIQASMDLGKGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR40</accession>
    <name>A0A398CR40_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsZ</name>
        <name evidence="7" type="synonym">rpsN</name>
        <name evidence="8" type="ORF">D3H35_02305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05003">
        <property type="protein sequence ID" value="RIE05003"/>
        <property type="gene ID" value="D3H35_02305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE05003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="61" mass="7280" checksum="BC8CDCE60DC5BCD5" modified="2018-12-05" version="1">MAKTSMKIKQQREPKFKVRAYTRCERCGRPHSVFQKFKICRICFRELAYKGQIPGVKKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRH2</accession>
    <name>A0A398CRH2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="6">2.7.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphatidylglycerophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">D3H35_14750</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein catalyzes the committed step to the synthesis of the acidic phospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02021">
        <property type="protein sequence ID" value="RIE02021"/>
        <property type="gene ID" value="D3H35_14750"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00934"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006655">
        <property type="term" value="P:phosphatidylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RIE02021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="168" mass="18629" checksum="3A7E8C8C9DD14C4F" modified="2018-12-05" version="1">MNLPNLLTMSRFALIPLFLALYWNDHPVAALLIVLLAGLTDILDGYIARRRGQITVTGSMLDPLADKTMMLTVVLSLLFNEKISWSVGAVMAFREIGMIASSAFFYFRGMKTVPANMMGKATTVVYYVAIVLLFLDQPGGSEVLWCGIALSFVTSGIYFMKFRNLNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRI9</accession>
    <name>A0A398CRI9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_01925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05153">
        <property type="protein sequence ID" value="RIE05153"/>
        <property type="gene ID" value="D3H35_01925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="27"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="135"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="335" mass="36618" checksum="D758F0CF93009201" modified="2018-12-05" version="1">MTKLKIGLISFAHSHAFDYLDGLLRMPNAIVAGIADDVPERSQELARRHSIPFYADYNQLLADETIDAVVICSENVRHAELTIASAHAGKHVLCEKPLGVSVSEMERMIAACREAGVQLMTAFPCRFLTPVVRAKEALERGDIGDIISFKATNRGSFPDPAWFSDRSLSGGGAVLDHTVHVMDLMNWFTGSPAKNVYAYADTLFDPERKRTIDDAGMVHVTFENGVFAVLDPSWSRNPGFPTWGDVTMDIIGTKGVISIDAFNQKNNVYGRASGKGEWQFWGDDMNAIMMEAFVTALTEGKAVPVTGEDGLKSTEVALRAYQSAVLGKPVSVKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRK7</accession>
    <name>A0A398CRK7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_02045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05173">
        <property type="protein sequence ID" value="RIE05173"/>
        <property type="gene ID" value="D3H35_02045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="307" mass="33670" checksum="35EC7D7C327B9D76" modified="2018-12-05" version="1">MWNSILRRLIASVFVVWGSLTLVFFIMNVLPGDPAELIVGQTATEETIAKLHESLGLNRPLLTQYTDYMSGIVRGDFGVSFISKEPVLHRLLEQFPATLTLTAASVIVALALGITLGILSAVYRNRLLDYVIRTLTLFSISMPTFWLGILLILIFSVSLRWLPAIGNGSFEQLVLPACCLGFACSGALARMVRNSILEVLGEPFVVTLRSKGLSERSVLYRHILRNALIPTITLTGILIGELLSGSVVTETVFSRQGIGRVVVDAIMQKDIPVVQAAILFASIFYILVNLAVDLSYSYVDPRVRSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRS8</accession>
    <name>A0A398CRS8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flagellar secretion chaperone FliS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fliS</name>
        <name evidence="7" type="ORF">D3H35_15010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FliS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02071">
        <property type="protein sequence ID" value="RIE02071"/>
        <property type="gene ID" value="D3H35_15010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16098">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003713">
        <property type="entry name" value="FliS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036584">
        <property type="entry name" value="FliS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34773">
        <property type="entry name" value="PTHR34773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02561">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039090">
        <property type="entry name" value="Flis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101116">
        <property type="entry name" value="SSF101116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00208">
        <property type="entry name" value="fliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="126" mass="14715" checksum="D8FB47705E8AEFFB" modified="2018-12-05" version="1">MLQPAVNSYKHNQVETAPPEDLTLMLYNGAIMFVKRAKQAIEKKDLNHAHHYNTRVQDIVDELIITLDRKYPISEQLLALYDYLKRRLIEANVSKEIAVLDEVEGFLSEFRDTWKQAMVLARSQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSB9</accession>
    <name>A0A398CSB9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03638">
        <property type="protein sequence ID" value="RIE03638"/>
        <property type="gene ID" value="D3H35_10070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="170" mass="19749" checksum="76E48B7919DA78AF" modified="2018-12-05" version="1">MQRKRAASTVYWTLALFFGFIAGRGAFGRLLADRLSRGKKYHTFSGRQADWRNSGKRYHTFGDWQADWRNSGKRYHTFSGRQADRSNSGMRCRTFGGRQADRRNSGKRYHTFSGRQAERRNSGKRYHTFSGRQAERRNSGKRCRTFGGWLGDWLSRGNSSRTIAAWGVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSN2</accession>
    <name>A0A398CSN2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="8">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mraY</name>
        <name evidence="9" type="ORF">D3H35_06480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04259">
        <property type="protein sequence ID" value="RIE04259"/>
        <property type="gene ID" value="D3H35_06480"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10555">
        <property type="entry name" value="MraY_sig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="321" mass="34718" checksum="0887945DCE991C12" modified="2018-12-05" version="1">MDYTSILWTLGVSFVLAVLFGPLFIPILRRMKFGQQVREDGPQSHLKKQGTPTMGGVIILLALTLSYLKFADHDSPAFWALLVACLGFGLVGFLDDYIKIAFKRSLGLTAKQKLFGQLLFAVIFCVILYSMDHSTAIGVPGTDWSVDLKWGYYLLVIVIFFASSNSVNFTDGLDGLLAGTSALAFGAFALIAVEATESHSAVFSAAVVGAVLGFLVYNKHPAKVFMGDSGSLGLGGGIAAVSILTKTELLLVVIGGVFVFEMLSVIIQVASFKTRGKRVFKMSPIHHHFELSGWSEWRVVTTFWAAGLVLAGVGLFLYRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSQ9</accession>
    <name>A0A398CSQ9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_06665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04289">
        <property type="protein sequence ID" value="RIE04289"/>
        <property type="gene ID" value="D3H35_06665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016667">
        <property type="entry name" value="Caps_polysacc_synth_CpsB/CapC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39181">
        <property type="entry name" value="PTHR39181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19567">
        <property type="entry name" value="CpsB_CapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="98" mass="10898" checksum="DC62F590B0D961A0" modified="2018-12-05" version="1">MIDIHTHILPGLDDGAQTIDDALEMARAAHEEGIEHIIATPHHANGSHMNAGRDVRLEVRRFNEQLQAADIPVTIHPGQEIRVHDDLLDAWGETSFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT86</accession>
    <name>A0A398CT86_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02174">
        <property type="protein sequence ID" value="RIE02174"/>
        <property type="gene ID" value="D3H35_15645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="88" mass="9183" checksum="794F1A18D2FA1A99" modified="2018-12-05" version="1">MIIVTIPARSRSSGGDVLISVTIPARSRDVGGDVMNSVTIPARSRSFGEGVMNSVTIPAHSRDVGGAVMNSVTIPARSWDVGSVKKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUB3</accession>
    <name>A0A398CUB3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02574">
        <property type="protein sequence ID" value="RIE02574"/>
        <property type="gene ID" value="D3H35_17980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="117" mass="13399" checksum="AA72AEFCA60619AF" modified="2018-12-05" version="1">MTVAERAVRRPIHRCAGAEFGERTVRRPTHRRAGAEFGERTVCRPTHQRAVAEFGERTVRRPTHRRAGAGFGERTVCRPTHQRAVAEFGERTVRRPTHRRAGAEFGERTVRVPYISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUF4</accession>
    <name>A0A398CUF4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03487">
        <property type="protein sequence ID" value="RIE03487"/>
        <property type="gene ID" value="D3H35_12630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="60" mass="6838" checksum="01A67EFFC4E85ADF" modified="2018-12-05" version="1">MQLPQFDERLLERVARLKPYIQQTVGLRRQHRIAAAIKLQLNVRQSAGRTAGLSLSGVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUK2</accession>
    <name>A0A398CUK2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_10835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03537">
        <property type="protein sequence ID" value="RIE03537"/>
        <property type="gene ID" value="D3H35_10835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="34"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="409" mass="44938" checksum="53BD51C4D463A106" modified="2018-12-05" version="1">MNPMSMNEHLSETARTLPPSGIRRFFDLAGASKDLISLGVGEPDFVTPEHVRQACIQALENGRTAYTPNSGLPELRQAIADYLKEGFRLEYEPSCEMMITVGSSEAIDLALRALIAPGDEIIVPVPTYIAYAPIAALHGGRVVELETSARDGFKLTAASLREKITSRTKAIILNFPNNPTGAIMTREDWIPVAQLIREHNLIVIADEIYAELTYEGRHVSIASLPGMQERTLLVSGFSKAFAMTGWRVGYVCGHRDLIGAMLKIHQYTVMCAPVIGQIAAVESLKQAGLEEMKYMIRSYDQRRRMFVEGLRRIGLPCREPQGAFYAFPSIAHTGLTSDQFAERLMNEAGVATVPGNVFGPGGEGFIRCTYASSVAKLTEALERMERFLARIAEERESEVPSPDVVLANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUL4</accession>
    <name>A0A398CUL4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_06985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04338">
        <property type="protein sequence ID" value="RIE04338"/>
        <property type="gene ID" value="D3H35_06985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="342" mass="37546" checksum="FC03FA16D76AE49A" modified="2018-12-05" version="1">MRIRSLTVRIVRQFIRDKRTLALIMLAPLLVLTLMKFVFEGQAADPRIGAVNVPAAALAVLEQTNADVTAYPDKDAALSDMKAGTLDAIVSFNGLRPEMTLEGSSPTKNRNAVAAIQASLRAVLESGSSEQPVISYLHGSGDMDIFDYYGSVLVGFFSFFFVFLIAGVSFLRERTTGTLQRLLATPLRRWEIVVGYLLGFGLFTLVQATLIAWYSTSVLGIALEGSLFLVLFMNLLLAVTALTLGTLLSAYAQNEFQMFQFIPLIVVPQIFFCGLIELDSLPQWLQAVGKILPLYYGADAMRGIMLRGDGWSDIGVDAAMLVGFSLLFAMLNVLALRKHRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUU2</accession>
    <name>A0A398CUU2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_02515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05029">
        <property type="protein sequence ID" value="RIE05029"/>
        <property type="gene ID" value="D3H35_02515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="310" mass="34442" checksum="5CB7B3729820FEAA" modified="2018-12-05" version="1">MEIRLIKTFLTIVKLGSFHEAAKALQYSQPTITVQVKKLEDELGIKLFERGKTTELTSAGRFFLQKAEKLLNQYDEFENELRDYRDGDAGIIRIGISEPSASNRFPAILSSFALKRPKVQIKVSIGSNKGLVDMLLNEEIDLAFCNRPEPHIELSFEHLLTETFGLLLPADHPLADLDKLHILDLKDEKFIMTPGTCPFRIRVEEAIAEKIGMLRQSSIEITGINSLKYFVQAKLGIALAPLVSISPPITGTVVKAVSDMIAGPDLGILTKKEAKGRSLVLTYLTDEIRRVSGEVDLESTPPLLLVANPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUV4</accession>
    <name>A0A398CUV4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03647">
        <property type="protein sequence ID" value="RIE03647"/>
        <property type="gene ID" value="D3H35_10120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="17"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="325" mass="35431" checksum="7EDBE663001D946B" modified="2018-12-05" version="1">MSRSISLHKHGINASRLALGCMGLGGGWNRNPVTAANVKEAHEAVDAALEAGINMFDHADIYTFGKAEQVFGEVLKERPELRDRIILQSKCGIVLAQAEGQSNRFDFSKDHILNSVDGILSRLGVGQLDVLLLHRPDPLMEPDEIAEAFGKLKQAGKVKRFGVSNMSAAQMRLIQASLDEPLVANQLELSLLKLDWLDSVVHVNQDAGKQVSYPEGTTEYCRLENVQIQAWSPLARGLFSGASLEGAASNVKDTAALVAKLAEEKGTSREAIVLAFLLRHPAGIQPVIGTVKPERIIASGKATDVELSREEWYLLYTTSRGRKMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVE4</accession>
    <name>A0A398CVE4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Crp/Fnr family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_07920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03887">
        <property type="protein sequence ID" value="RIE03887"/>
        <property type="gene ID" value="D3H35_07920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="220" mass="24994" checksum="2EE7163834F5D3EF" modified="2018-12-05" version="1">MIEWLKKVSLFDNLNDDQLEHILRIANRRTFQTGTILFQEKDYGNTFYVVLTGTIKLFTRSNSGEEKILSLVNAGESFGELSLLDGRPRSASAQTLETTTVLELSSQTFMELLQTHFDITRGILAELCRRLRQTNEHVNDLTFLDGRTRVLKNLITLANQNGKRDGQIITVHMALNFDELAQMAGVTKIVLTDVIREFESRGVLQFGIGEYKINLLKLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVF2</accession>
    <name>A0A398CVF2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2129 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04498">
        <property type="protein sequence ID" value="RIE04498"/>
        <property type="gene ID" value="D3H35_07245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016979">
        <property type="entry name" value="DUF2129"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09902">
        <property type="entry name" value="DUF2129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031653">
        <property type="entry name" value="UCP031653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="87" mass="10412" checksum="A8322A6489AA5632" modified="2018-12-05" version="1">MFAERTGYIVWVSDIKAARGLDKYGTVHYMSRKMNYAVMYMNADAAEEAVRNLQRLPYVRKIERSYRNEIKTEYEKNVPDKTRFYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVM4</accession>
    <name>A0A398CVM4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_05650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04588">
        <property type="protein sequence ID" value="RIE04588"/>
        <property type="gene ID" value="D3H35_05650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="6"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="73"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE04588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="294" mass="33793" checksum="E7A3EA4B8517B3F2" modified="2018-12-05" version="1">MVLLNWRRFLYVEHLNRAVEHIANGNFNDSVPVRQRNEVSVLAENTNMLVEKLKRSLDDERRAEQTKNELITNVSHDLRTPLTSIIGYLGLIDQDRYRDEVELRHYVQIAHAKAERLNALINDLFEYTRMNSGVIFLRAIPFNLVEMMNQLVVHYRLQLEQAGLEGQVHSASPEVVVQGDPEKLVRVFENLLANAMQYGKDGKKVDIHIRKESRMAVIEVVNYGEPIPPSDLPYLFDRFYRIDKSRTEHAGGSGLGLAIVKSLVEKHDGMIQAESDSRRTVFRIKLPLPQEAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWG9</accession>
    <name>A0A398CWG9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_11015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03561">
        <property type="protein sequence ID" value="RIE03561"/>
        <property type="gene ID" value="D3H35_11015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015594">
        <property type="term" value="F:ABC-type putrescine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03300">
        <property type="entry name" value="ABC_PotA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017879">
        <property type="entry name" value="PotA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="15"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="372"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="420" mass="46856" checksum="40287F03CE7AABF1" modified="2018-12-05" version="1">MERKRVAVVNSNAIIRFDNVTQRYDSGVVLHDVSFEIEHGKFYTLLGPSGCGKTTILRLIAGFAEPSEGSIYFHGKKINDVPPNKRQVNTVFQDYALFPHLNVFENVAFGLRIRKLKNDQVEAKVKEALRFVGLADYENREISEMSGGQRQRVAIARAIINEPEILLLDEPLSALDLKLRTEMQVELRELQRRLGITFVFVTHDQEEALAMSDEIIVLNKGKIEQSGTPTDIYDEPINRFVADFIGESNLLAGRMIRDYLVEFGGQTFECVDGGFNDNETVDIVIRPEDLEITAPGSGQLRIRVDSQLFRGVHYEIGGTDKTGNKWLVHSTRKVSVGEEIGLAFEPEAIHIMRLGETEEEFDKRLEAYSDTEEEAEIADEGKAVKGEAAKGIGPETASKKTADTIAEKAPNGHSGGHHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWI3</accession>
    <name>A0A398CWI3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_06085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04187">
        <property type="protein sequence ID" value="RIE04187"/>
        <property type="gene ID" value="D3H35_06085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="148" mass="16487" checksum="C5285EA4B74CF94D" modified="2018-12-05" version="1">MKEISAGGVVYRKENGAIEIQLIQDRFGKMTLAKGKMEPGETIEQTALREIEEETGIVGAIVDTLSVIAYQYEAKGRGTIHKEVHYFLVEATEGRLQAQVEEITGVGWYSPEEAWRLQLLSGYDNNDEIVRSGLRKLGTEVEPNARSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWW6</accession>
    <name>A0A398CWW6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03504">
        <property type="protein sequence ID" value="RIE03504"/>
        <property type="gene ID" value="D3H35_12715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="97" mass="11279" checksum="CF0F502718F9333C" modified="2018-12-05" version="1">MRWLYWISTADQRQRLSHLLSVRGQRGSPLDAGQAESGRSSRRTADVQLQFYRGSNPMLPPQPYGLLDIRLEARYPFEEALVKLRELHPEPGLNRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWX5</accession>
    <name>A0A398CWX5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_02810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05078">
        <property type="protein sequence ID" value="RIE05078"/>
        <property type="gene ID" value="D3H35_02810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="90"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="317" mass="36310" checksum="713415E0C4E100A0" modified="2018-12-05" version="1">MMAKENIAGSSLTQKTFFQSLSHRLWRDRYIYLLLLPGLIYFLMFKIIPIFGNVIAFQNFNPFKGIMESDFVGFANFQRIFEDSEVLRVLRNTLFISLMQIVFVFPAPILLAIMLNELANERIKRFIQSIVYLPHFFSWVVIISIATIFLKPEGLINQLLMYMGYDWVSFMTNSHLFVPIVIVELIWKETGWSTIIFLAALASINHELLEAAIVDGANRWKRIWHIIVPSIGPTVVILLILRLGTVLDSGFEQIFLMLNPFNKEIGNVLDTFVYEKGIKQSDYSFSAAVGLFKGLVGLVLVLGANRIVKRFGHDGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWY7</accession>
    <name>A0A398CWY7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03524">
        <property type="protein sequence ID" value="RIE03524"/>
        <property type="gene ID" value="D3H35_12155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010394">
        <property type="entry name" value="5-nucleotidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31367">
        <property type="entry name" value="PTHR31367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06189">
        <property type="entry name" value="5-nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="310" mass="34847" checksum="6C4ECF24B5F812B0" modified="2018-12-05" version="1">MGYQIQEKFVVAVASSALFDLSESDSVFQKSGEDEYRTYQRRNENVVLGKGVAFPLIKRLLNMNGTDSDDRQVEVVLLSRNDPDTGLRVFKSIEHYELPISRAVFVTGNDPFNYMDAFNASLFLSGNKEDVKQAVALGLPAGCVYPTDFVDDDADDELRIAFDFDGIIADDSSESVYEQGAIELFHQHERLKAGEPMPEGPLLRFFLEISKLQKRELAKKAEKADYRTKIRVAIATARNAPAHERVISTLRKLDIRIDEAFFLGGIDKERVLKIFKPHIFFDDQVGHIEGVARIAPSVHVPFGVRNAGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX27</accession>
    <name>A0A398CX27_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methylenetetrahydrofolate reductase (NAD(P)H)</fullName>
            <ecNumber evidence="5">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D3H35_07305</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04387">
        <property type="protein sequence ID" value="RIE04387"/>
        <property type="gene ID" value="D3H35_07305"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106312">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106313">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADPH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="12">
        <location>
            <begin position="4"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE04387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="630" mass="67685" checksum="FBE64CC2760E051B" modified="2018-12-05" version="1">MRPDLRSALSLSHRPLVGDGAMGTFLYQLGFPVGVSYEEFNLLKPGVIGDVHRRYVEAGAEVIETNTFSAQHGKLSKYGLEKKVEAINAAGVAIAREAAGDRAYVVGAIGAIRAGRRRAVRTATIKREYEEQIGAILAAGVDGLLLETFFDLEELSLALGLIRAKSDLPVICQFAVEDTDRTHDGVLLGEAFRRLKGEGADVIGFNCRSGPNAILRAMQTIPRDLGASLSAFPNAGIADLVDGKVVYSATPEYFASSALRFADLNARLIGGCCGTTPDHIAAIAKALRDYSPSPERENGNAGGVDSAVKTGAGAEERPVYDGGRFGDEPSIVELVKHRHTVIVELDPPRDLDIAKFMAGAKALKEAKADALTMADNSLAVTRMSNMALAALVKERIGIRSLAHIACRDRNLIGTQSHMMGFDALGIDHVLAVTGDPAKFGDLPGSSSVYDTTSFEIIRMIKQLNEGVAFSGKPLKQKARFVVGAAFNPNVKHLDKAVQRLEKKVQAGADYIMTQPVYDAGLIERIAEATKHIPIPVFLGIFPLASGRNAEYLHNEVPGIQLSDEVRERMRGLEGAEGRAEGVRIAQELLDTAMKHFNGIYLMTPFLSYEMTVALTAYVKEKSAVIAQAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXE3</accession>
    <name>A0A398CXE3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04437">
        <property type="protein sequence ID" value="RIE04437"/>
        <property type="gene ID" value="D3H35_07585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="132" mass="14981" checksum="7BAFCC03634CE42A" modified="2018-12-05" version="1">MSHGFHHGPITVAATLDDLISQVTAFYTEDWQKRQNEIIILDFTHFDNYDDKERPGALQSFFTALYNSSLNPYLIPQGSFGPNTTLNSLWTASTQQRVIASVNFDPSSYQNTGNIWNGKKLFADEWDVPNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXW4</accession>
    <name>A0A398CXW4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03834">
        <property type="protein sequence ID" value="RIE03834"/>
        <property type="gene ID" value="D3H35_09785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="273" mass="30280" checksum="9D434A2735B72AB0" modified="2018-12-05" version="1">MVNFLKLVQNENMKIYRRLRTWIMLGAIVLIPILISIIWKLTTDGPDPSNWHATNQEFGFVLMLITIFTVVQSAESVAGEFTWGTIKLLLIRPWSRSVILLSKYLSLILFALFFTVIAFAVTLLANIAIFGYTDNPGDYLARFSMGGQLAVDLSPWTLMLEDIGLQLVSLVMIVSFAFMLSSAFRSGGLAIGLSIFLLFAGSIITAILASANGTWVKYVMFIHLDLSSYLNGGDGPIPNHPMTMSFSLAVLAVYFIIFNLVSWTVFVKRDVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXZ2</accession>
    <name>A0A398CXZ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_09960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03864">
        <property type="protein sequence ID" value="RIE03864"/>
        <property type="gene ID" value="D3H35_09960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017348999" evidence="5">
        <location>
            <begin position="31"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lacI-type" evidence="6">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="344" mass="37656" checksum="CADF8F6BADC0139F" modified="2018-12-05" version="1">MATMKDVAKKAGVAPITVSRVLNNPGSVASATKKKVMKAIEELNFKPNQIARSMITRRTNTIGMLLSNITNPYFPEVLLGLEVTARSQGKNLIICNAIDYENTLRSLDVLLEKRVDGIIVAPIEFPSVESQKEFYSYLESLSSKLSDQSIPVVFINNDLQETSLSCVSIDNYLSARLAMEHLLALGHKRIAHLTVERDVKVWIERLRGYKDMLASSGIAIDSSLIAMGSEDVESAERAALELLKRKERPTAVFAANDTLAIGVIHAANRLGLNVPRDLSVIGIDGTPLGLYIYPKLTSVSHPRFQIGEVSVKLIIDKINGDTSNFNVTLKPELLARDSTGPVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY15</accession>
    <name>A0A398CY15_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03884">
        <property type="protein sequence ID" value="RIE03884"/>
        <property type="gene ID" value="D3H35_07905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="80" mass="9341" checksum="67F00993E2FED35F" modified="2018-12-05" version="1">MTDQSNGLRFDIYERVHLPDEVAAIEELEEIELVPHMQALPQEDEVLLRGICCYPACTNRKIRPESRSWSIGFRSKLHCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY30</accession>
    <name>A0A398CY30_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04131">
        <property type="protein sequence ID" value="RIE04131"/>
        <property type="gene ID" value="D3H35_08440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017480017" evidence="1">
        <location>
            <begin position="35"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="473" mass="52445" checksum="67F020E5FCFDF235" modified="2018-12-05" version="1">MRKRLLTTVAALTLATSVLAGCSSNNNEAGNAAATDSGQTTTGKKEKVDIKVWLTPQWKGVLDASEQGADYDSFFKYAAKKFSEQYDKYDAKINVEVIAGDQRDQLLNVNLSGGTPPDVFFESVFAMGDYVHRGALVPLTDIVDDEAKKDINESYWNTVTFGNDVYFYPFQNNPGTLVYNADMFKAAGLEKYVGGDTEIKTWTLAEYEDILKNLKDNLPKDKYSNAYPMALYGVNNQGDTWNLAYLRMFGNKFFDDQGNIVLNDENGVKAAAWLKKIKDAGYTNPGPESVSSNDANAMFLNQQLAISFTNPVLFNNAKADMESGKTTKFDLRLANIPSESGDPLSFTYVVGASVFQSKDAKRVEVAKDFVKFFSTDPELVKSSKNAIPVRSSVAEAYKAEKPLFAAYDANSKYLFNFTGNVPGYSQLREVLYPELQALYMGAKKPEQVVKDYQEKGNKLIETNKASSVIFQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY42</accession>
    <name>A0A398CY42_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-layer homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_04275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04707">
        <property type="protein sequence ID" value="RIE04707"/>
        <property type="gene ID" value="D3H35_04275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017323836" evidence="1">
        <location>
            <begin position="35"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="35"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="171"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="901" mass="95937" checksum="8C5244BA5A4C0B46" modified="2018-12-05" version="1">MNKETSRLKQGMIGLTAAALITTGVLGTGASSFAASNPFSDVAAGHWAEKHITKLALQGIVLGSNGKFRPSDKVTRQEAIIIALKFMGLADQVDDSGVLAFPSSLVIKDDYKKFLKAAFLNKLLIPEEEIALAESEKGKKWGYEPASREWLTRLLVRAIGKQEEAASNTGSTAFADDSSIDDALRGYVKVAVSEGLVSGMTATTFEPKTAVNRAMIARLFSLAEAKTKVAYSGQASGTIIDVSDTSITVLHDDGTINERVLTPDTVFYRFDSDKPITIADLKLFGKASLISDGDGAIGYVEQTDDTPQVKSYDGTLTLKNTTTGKLTLLIGEEYKPFTYDLLHPPVIKDFTGKTISAADLPVNVDVSVQVDTIRAEGKVLTVTVKQAVENKSGSGTVVAWDPAALSLEVKDAVSGVTEKLKVSTQATYVRGDVPVKADNLKVGDAISYDVKLGAVSSVQIAQAAVTSVTGKFVSLNKSEKIITYNDGKGLASKYVIDYPSVKIDGMTDATVEDLQKDDQVTLSLNDADKVTQIAVNDRSVIVTSATVAGYIADTRTLSLIDAAGKTRNLILPSNVRYDMNGTSLTEASALALVGVKGKKIVVAYSGENVVYVSIVAKYNGTVVENNTSSRTLKISLTGTTNQTVTVPYSYPAVEWFGTNAKTYADVKVGDVVSVLLNGNQDQASIIQMQKTVQLEIVSVDAINNKIRTKRADGVLDDWYIATSIGLQDESGNAASLGAFTAGAVANVTFVGNTPVKFKQVSVQYGTIKSVNTAASTVELTLPNGSTVTKSVGASPLITINGATSSTLSSVQANDRVEIRKDESERTVIQVVPALSKVVWTVELSTRTLNVKRANLTENYSFPVPAQAYIHQGATTLTLSDLKPDDTIKLYILRGVVVEVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY61</accession>
    <name>A0A398CY61_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MMPL family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_05920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04161">
        <property type="protein sequence ID" value="RIE04161"/>
        <property type="gene ID" value="D3H35_05920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="561"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="585"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="664"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="691"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="610"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="739" mass="79021" checksum="A05D29776A851D67" modified="2018-12-05" version="1">MNPKSGLAKWVTGKWSRWVTLLIWIAAAGLMSALLPSVNNEEKNNAPNLSDSKPSVQAEALANREFPGGADIPALLVWHRGTGLTDEDLQHIQKLSGQWTEAPVPHQTSIPPLHQVPLAALKGQLSEDGSTLVTPVFFSKSADTDQLKEGVDKLKEDAAALLGANPFEAAAGSDNELTARATGPVGIQIDATGLFKNADFALLMATVVLVLALLLLIYRSPILAFIPLVAVGFAYGVIGPLLGWMAHEGWITVDSQGISIMTVLLFGAGTDYCLFLIARFRQLLKTEGDKGKALRAAFSGASGAIAMSGFTVVLSLLALLAAEYGAYHRFAAPFSIAIFVMGIASLTLVPALLAIIGRASFWPFVPRTEGMQAERARKKGKPAPHAAAAPRYRIGSAVVKRPALIVIASIIVLGGFAAFTPQIKFTFDILSSFPEDMASREGFKTIGEKFSEGELAPVKVMADTQGKAVSLENDLRALPYVAELSKPTIGKETPSIVAYDVTLSMNPYSLEAMGHIPDLRAAVESSLQKAGADSPENSVWIGGQTAEQHDTKVTGDRDTRVIIPIIIGMITLLLLVYLRSVVATVYLVLTVILSYFSALGLGWLVLHFGFGVDAISGSIPLYSFVFLVALGEDYNIFMISSIWQKRKTMPLKQAIREGVGETGSVITSAGLILAGTFAVLASLPIQVLVQFGTITAIGVLLDTFVVRPFLVPAITTLLGRRAFWPGKYAPIEERNVRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYG7</accession>
    <name>A0A398CYG7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SEC-C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_05230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04867">
        <property type="protein sequence ID" value="RIE04867"/>
        <property type="gene ID" value="D3H35_05230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="335" mass="38658" checksum="FCC9F82146E04ACF" modified="2018-12-05" version="1">MRIGRNEKCPCKSGKKFKNCCINDPKYTETQLNNGIPRKYMSEFALHTYSSQVTIVSPKLLENVDVSNASYHIYMINKIKRLSFVENSIKVLDTHVEIQIKHGGTLIDKIEIIEIPLHDDIVSYEFESDKILVMKDGYGGGLKADILWLYSTFSNEELVCEVLYVGQSFGKKGDRDALLRLKSHETLQKILVDILYEDINYEVAITLWEFTPRLIALIDGRNGFLVSAKEDKQHFEKVLSAPNINIDNQIINVTEAALINYFKPKYNDKFKNNFPDITHKGYTFYYNYDYNAIAVELDPSCVNIKIHSEHTGYSQFSPVEYLLNSEEKRKSMFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYQ2</accession>
    <name>A0A398CYQ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04361">
        <property type="protein sequence ID" value="RIE04361"/>
        <property type="gene ID" value="D3H35_07130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="267" mass="30002" checksum="BEE986FF9EBC6DC5" modified="2018-12-05" version="1">MTWNDREICKIAEHRLFIDCSSASLGHYLELAFGPFRERVADYTDAADMNIRIDEGFGVPFSGYEVAVSQSNDGVVFARADYRITADTAYYNVRIEAFDGFSLKHALLQLYSAFITNREWGLLVHSSCVLKGERAYLFAGPSGAGKSTVVRHSYPRPILSDEASIVKIESGRVVAFNSPFRSDIHASSGSEAHPLAGIQFLRQAPRNRRLLMRSSDGLLKLLTTVFHWAHSPAENAKALRLCKRMVGLVPVYDFHFVQNESFWEEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYT8</accession>
    <name>A0A398CYT8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplP</name>
        <name evidence="10" type="ORF">D3H35_02275</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE04997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04997">
        <property type="protein sequence ID" value="RIE04997"/>
        <property type="gene ID" value="D3H35_02275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="9">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="145" mass="16336" checksum="7B404C9A5D021C40" modified="2018-12-05" version="1">MLIPKRVKHRKQHRGKMKGMAKGGTEVHFGEYGLQAQEPSWVTNRQIEAARIAMTRYIKRGGKVWIKIFPSKPITQKPLEVRMGSGKGNVEKWVAVVKPGKILFELAGVPEEIAREAMRLAAHKLPIKTKFVKREELGGEANEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZI0</accession>
    <name>A0A398CZI0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_01730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05267">
        <property type="protein sequence ID" value="RIE05267"/>
        <property type="gene ID" value="D3H35_01730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004761">
        <property type="entry name" value="Spore_GerAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34975">
        <property type="entry name" value="PTHR34975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03845">
        <property type="entry name" value="Spore_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00912">
        <property type="entry name" value="2A0309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="356" mass="40339" checksum="8B33B7F494E50047" modified="2018-12-05" version="1">MNKQALRVGPFQLYCILMQAQFGSAVISIASDLNDKSGTSAWISCLIGGLANMIFVYLIWLLASKAPNSNVFQMLLQRLGGIFGRCLLAILAAFYAGIAYVILTNWIYTTDLWAYERTPKWVLLFLFIALCSYLVIQPVTVYARFAVLTTFFAPLFVIFAVYMFKDWNTYNLLPLLDKGPLKLLRGSVVVLWALAGIEILLVIPQYVKHLGARKVLRIALLSNGTTVLFYTFSVFSSLVLFGSEMISYIREPLLYQMKAVSFDIIERMDLIIISVWILFVMTSFCSYFILCVSSIAAMLKKKEEVPLWLALVCGGLLFIASIWRFSADQLDRFHEIINYWGHGSVIRINCRHIIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZL9</accession>
    <name>A0A398CZL9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000012">
        <property type="protein sequence ID" value="RIE05307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05307">
        <property type="protein sequence ID" value="RIE05307"/>
        <property type="gene ID" value="D3H35_01280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="89" mass="9335" checksum="484EFF730DF3CD4A" modified="2018-12-05" version="1">MEQEGQDYVDMQMGNSADGATYGNVNSPTFVSYTVQMKDGADADKIIDAVKGQRANYPGADLNAGPGSFFGGGSSTQVFVDVTATIWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZT8</accession>
    <name>A0A398CZT8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type III-B CRISPR module RAMP protein Cmr6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cmr6</name>
        <name evidence="2" type="ORF">D3H35_00905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05377">
        <property type="protein sequence ID" value="RIE05377"/>
        <property type="gene ID" value="D3H35_00905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010172">
        <property type="entry name" value="CRISPR-assoc_prot_TM1791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39965">
        <property type="entry name" value="PTHR39965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01898">
        <property type="entry name" value="cas_TM1791_cmr6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="274" mass="31219" checksum="74D349884838FC90" modified="2018-12-05" version="1">MNAYLSMTKSVGLKNNDLLEEVIKKGQLRQDFNKEVVNVYTACRDELEWKQWYHHRYYQRFKLSVRENSRHSESGSDWKEGVFTQECASSVITGQGQSSVLETHLTVHPVYGFPYFPGTMIKGAAAHYCHRVLGAQEERFRENGDYYTMLFGSKEQASVIQYEDAWPDPECAETGLCHDVLTPHHRNYQSLKTGGEKHSDAALADFAPRDDDSPDPVHFLAVKGRFTFKLTIDPEVREAEKWLPVAEKIVKAMLNREGLGGKSSSGYGLFEEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0B6</accession>
    <name>A0A398D0B6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_03435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000021">
        <property type="protein sequence ID" value="RIE04921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04921">
        <property type="protein sequence ID" value="RIE04921"/>
        <property type="gene ID" value="D3H35_03435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="214" mass="25930" checksum="C1171D0A0A8CD6F3" modified="2018-12-05" version="1">MGWRPIVERLHNKFAQRVGRRPIVECQKQQFAKRMGWRPIVECLHNKFAQRVGWRPIVERLDNKFAQRVGWRPIVECQNNKFAKRVGWRPIVERLHNKFAQRVGRRPIVECQNNKFAKRVGWRPIVERLDNKFAQRVGWRPIVERLDNKFAKRVGWRPIVERQNNKFAERVGRRPIVERQNNKFAKRMGWRPIVERLHNKFAKRVGWRPIATRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0L6</accession>
    <name>A0A398D0L6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="12">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alpha-IPM isomerase</fullName>
            <shortName evidence="12">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">leuC</name>
        <name evidence="14" type="ORF">D3H35_04260</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="12"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04704">
        <property type="protein sequence ID" value="RIE04704"/>
        <property type="gene ID" value="D3H35_04260"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 12" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="10 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="13">
        <location>
            <begin position="8"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE04704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="473" mass="51539" checksum="02A40D5D2535479C" modified="2018-12-05" version="1">MSKKTMFEKIWDNHVIVSEEGKPSILYIDLHLVHEVTSPQAFEGLRMTGRKVRRPDLTFATMDHNVPTKDRFNIADPISKQQVDTLTSNCREFGVTLYDLDSLDQGVVHVMGPELGLTHPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVMATQCLQQAKPKTMEVRFNGKRKPGITAKDLILGLIAKYGTDFATGYVIEYTGEAIRGLSMEERMTVCNMSIEGGARAGLIAPDQTTFDYLKGREHAPQGEAFEAAVKRWEALGTDEGATYDTTVDFDVDSLVPQVTWGTSPGMGTDITSKVPVPAELPTENERKAAEKALEYMDLQPGTPMQEIPIDYVFIGSCTNGRIEDLRAAAAVARGYQVSSNVTAIVVPGSGRVKIQAEKEGLDQIFTAAGFEWRDAGCSMCLAMNPDYLLPGQRCASTSNRNFEGRQGRGGRTHLVSPEMAAAAAVKGKFTDVRNWEFKSEVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCH9</accession>
    <name>A0A398CCH9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alkaline phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_28900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00430">
        <property type="protein sequence ID" value="RIE00430"/>
        <property type="gene ID" value="D3H35_28900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="3">
        <location>
            <begin position="380"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="518" mass="58838" checksum="FA41134FF8DB7C32" modified="2018-12-05" version="1">MKKASSFEIVAARCWNLLNEGKPFLPIFVVGAFALYRADQWLDSGFWLAAFQSLLLVVPLLAIYYRYDYPLFLRNYLWLPVVGALLVWEPADLSLYASAIGLYFFFTVFFWGTFYYRMRIGTTWWNFSRFWKLVLKNSDSTSGNAQEQLPKLLLVLFLWNHYYRAIGSGESQLWQTADLSEGLVPLGLFTAGLWLYSWILHANLFDWKPKEKEGLTEDPDATGRGLNEKVIVIVVDGMRKERFEEAEAPFLKKLRAEGTEYAQMETVYPARTVVCFSSMFTGAYPKDHGIRSNMVWKLGIKVESIFDSLRKVGKKGNLLGIAHLIDSMGDDVESVTAVMHNDLADRQIIERAKRIMAEQNPDLFVVQLIGVDQTGHSRGVLYDEYIQKIAEADKLIEEYVGWLTDRGMMNNTTLIICADHGQADGIGGHGHLDEGERFVPFFMHGPAIRQGCRIDERHSLISMAPTIARLLGAPYPNRSRGPVLTDALKSSQTIDTDIRENSHERSQKQEAGRLYPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDH4</accession>
    <name>A0A398CDH4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_28240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000055">
        <property type="protein sequence ID" value="RIE00475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00475">
        <property type="protein sequence ID" value="RIE00475"/>
        <property type="gene ID" value="D3H35_28240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="41"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="175" mass="19260" checksum="4B4AE74678AA871F" modified="2018-12-05" version="1">MHDPVVLRAGRADAADANGKLDRKALPSPEGTLERGTVYEAPRNALEETLANIWQGVLGVSAIGITDNFFELGGDSIKAIQISARLHAHHLKMEIKDLFQHPTIGKLSSCLRPVGRTIDQGLVEGEVELTPIQRWFFEQTSRTGRTVKKTGSYAVVFESELTYAELNDGESLREC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE16</accession>
    <name>A0A398CE16_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_25675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00953">
        <property type="protein sequence ID" value="RIE00953"/>
        <property type="gene ID" value="D3H35_25675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="240" mass="26163" checksum="94457518A0C3AAC5" modified="2018-12-05" version="1">MIKVSGLKKAYGKHVVLNGIDADISKGEVVVVIGPSGSGKSTFLRCLNLLETPTDGAIEFEGKPITESGVPIDALRQSMGMVFQQFNLFPHMTVLENVTIAPIKVRKLPRAEAERDGLALLRRVGLEEKSGTYPSRLSGGQKQRVAIARALAMKPHVMLFDEPTSALDPEMVGEVLDVMKSLAKDGMTMVIVTHEMGFAREVGDRLLFVDGGVIVEQGDPREVFANPKHPRTKEFLSKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEC4</accession>
    <name>A0A398CEC4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron-sulfur cluster-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_26765</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00795">
        <property type="protein sequence ID" value="RIE00795"/>
        <property type="gene ID" value="D3H35_26765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019516">
        <property type="term" value="P:lactate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004452">
        <property type="entry name" value="4Fe-4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024569">
        <property type="entry name" value="4Fe-4S-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47153">
        <property type="entry name" value="PTHR47153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11870">
        <property type="entry name" value="DUF3390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00273">
        <property type="entry name" value="TIGR00273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="304"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="507" mass="55848" checksum="BF05E77AF3B72A4A" modified="2018-12-05" version="1">MSGTGTVPGTVKERSELALNDEFLRKAVKFTTERLRNGKKNASEEHGNWDEWRERGRQIRLHTIAHLDYYLNLFADNARANGVHVHFADTSAEAVAIALEIAKRKEGKTVVKSKSMVTEELHLNHALEEIGVEAIETDLGEYIIQLAGETPSHIIIPAIHKNRYQIADLLSKEAGETLAPDTQILAGFVRKKLREKFLEADIGMTGCNFAIAETGSMVLFENEGNARMVTTVPKTQITLMGMERIIPSWTDLEVMATLLPRSATGQKLTVYMSGITGPRRQEDADGPEEMHIIIVDNGRSLQLGDPEFQELLNCIRCGACLNACPVYRHIGGHAYGGTYSGPIGAVLTPALKKNVAEWDDIANASSLCGACYEACPVKIPLHEMLIYLRRRKVEAGRGNKLESIGMKGFATVMGKSGRFRAALRLGKLGQKLVARDGAIRLKVGPLKGWNSYRVAPTLPKESFRDRWGTLEQEIRGGLKEIDPSVRERMEAIAKAAREGKGGHGHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEE4</accession>
    <name>A0A398CEE4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_21330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01000">
        <property type="protein sequence ID" value="RIE01000"/>
        <property type="gene ID" value="D3H35_21330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041380">
        <property type="entry name" value="Acetyltransf_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17668">
        <property type="entry name" value="Acetyltransf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="305" mass="34967" checksum="6C33CB931147BD7B" modified="2018-12-05" version="1">MMTLRNVRENEFDDLMALWQFAFQIQMPPERVEKERESFRADNHWGLFDENGRLLTNLSILPLEVWIHGVRMKMGGVASVSSWPDARRQGGVTKLLHHALRKMREAGQTISMLHPFSVPFYRKYGYELTVTRKQYTIETKHFPPRADVPGTVAIVPKRSELLNDVYEQYAAKYSCTLARTDDWWERKVLSKPGVAALYRNPDGIAEGYLLYEAADRKMRIHEWVHTTETARAALWSFIGNHDSMIDQLVMMARRTMTCLSCCRSRGSSKSCCLISCRVSWMWSGSSSRIPLRLPSGGCIGDPGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFE8</accession>
    <name>A0A398CFE8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01916">
        <property type="protein sequence ID" value="RIE01916"/>
        <property type="gene ID" value="D3H35_14145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="210" mass="24312" checksum="7C865FF5E4897DC5" modified="2018-12-05" version="1">MLNCSQKPERAKGSYELKGKFAEKGRTTFINPTLHPEEYRTDRRCQLRIRNVNNERDAARSKKALRGITAGASRCSYFSCGCDGQRRNGSGIGRFPWSRRPRCRHAIYHASGLTGSPSRWQRRNEDDSIVPRTDSRRQRARKLREWKRFKSEGWIRDALAKSYAWDGEQFVFIVWELTGRAWFRDAAGAFVKRDSAAEQLFARIFKSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFH6</accession>
    <name>A0A398CFH6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01946">
        <property type="protein sequence ID" value="RIE01946"/>
        <property type="gene ID" value="D3H35_14330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="81" mass="9265" checksum="CAD97750C289652E" modified="2018-12-05" version="1">MDDTELCSTDCQSLLEQSARHRLAHPFLTDSRSNANTPHTADKGSHEAWFFVLKRILSGFVDSGFQSFPFDCRRDQFVERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFI6</accession>
    <name>A0A398CFI6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LysR_substrate domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01956">
        <property type="protein sequence ID" value="RIE01956"/>
        <property type="gene ID" value="D3H35_14385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysR_substrate" evidence="1">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="111" mass="12442" checksum="5A8B587A2055A576" modified="2018-12-05" version="1">MYMASSDNRLRHACGNRGMFAEFGIHPKRLMEMGSTQSIKETVEAGLGLTLQSNLCLRKELGLGTLKLLDVAGLPVRRNFHILIRVGDLRTRTLDVFLEALRLVTAEMNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFY3</accession>
    <name>A0A398CFY3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prepilin-type N-terminal cleavage/methylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_23520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for transformation and DNA binding.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01345">
        <property type="protein sequence ID" value="RIE01345"/>
        <property type="gene ID" value="D3H35_23520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030420">
        <property type="term" value="P:establishment of competence for transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0178">Competence</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="211" mass="23194" checksum="462C9A12481EE96B" modified="2018-12-05" version="1">MLKYANNQKGLTLIELLGAIALSAIVTTTAFFIFSGLTNFTQASSKEGRQAQNEAKFALSQLSTRLQDSIGIFAPTDKNELRYSVFVDETKVAYKAVYYENGTLTLYDFVGTTGDWSDDKVSLKSTPPAPRTSYADLYKKKYTLAQNLFAAPTYNTKSAGALTALVGSATKNSLIEISIKYKNTSRAFDGTLQFTGEKTLQTTFKRFNDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG01</accession>
    <name>A0A398CG01_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YkgJ family cysteine cluster protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_26805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00842">
        <property type="protein sequence ID" value="RIE00842"/>
        <property type="gene ID" value="D3H35_26805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="84" mass="8996" checksum="0535062553587A73" modified="2018-12-05" version="1">MECRIGCAACCIAPSISSPIPGMPNGKPAGVRCVQLAEDNKCKLFGKPERPAVCGDLHAEIFMCGSSNEEAYAILEKLERDTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG09</accession>
    <name>A0A398CG09_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DeoR/GlpR transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_15380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02136">
        <property type="protein sequence ID" value="RIE02136"/>
        <property type="gene ID" value="D3H35_15380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="261" mass="28809" checksum="70FB0257708D166B" modified="2018-12-05" version="1">MSISSEERKRVILEHLRLEGRVKVPDLSRRCGVSEETVRRDLFVLEREGRVKRVYGGAVLSDPANYEPPYLQRQKARAEEKVRIGRAAAELIVSGDTIVIDAGTTTLELAKAIAGRERLTVLTNSIAVAYYLMESLNAGRFSGKIIVIGGELNPEQQSLSGATGEQVMSQFRVDKAFISVGGISMKRGVSDYDLNETIMSRRMVESADQTIALADDSKLDKEAFVEIVPIRGVHTIVSNVPPPKGWIPSLKSNQVQWIQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGI9</accession>
    <name>A0A398CGI9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1934 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01062">
        <property type="protein sequence ID" value="RIE01062"/>
        <property type="gene ID" value="D3H35_21775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015231">
        <property type="entry name" value="DUF1934"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09148">
        <property type="entry name" value="DUF1934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="156" mass="17632" checksum="6989666A07CC333B" modified="2018-12-05" version="1">MPRDGASDEKALVRIRLESDAGGEKQEQSLEGEWYSKNRTIYLRYEETEGANLVRTLLSWKDGRLRLVRQGDVESEQIFSAGGRHSGYYRSDNVQFPLETETSFLRIVSSGGEGPGDQTPSPKLPMLLEWHYTLRIAGEDAGLFVIRLHAESIEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGV7</accession>
    <name>A0A398CGV7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Efflux RND transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01700">
        <property type="protein sequence ID" value="RIE01700"/>
        <property type="gene ID" value="D3H35_12870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="539"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="864"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="890"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="918"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="969"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1036" mass="111021" checksum="8DBDDE9D905E2365" modified="2018-12-05" version="1">MQTGSREERENVNWLTRISLKNSVAVVILCILILGYGLYSATQIKQQTLPDLEFPAVFVQVVQPGASTEEMETEVTKPLEESLKSIQGYESLTSTSSENFANIAIQFPFGSDMDKLFNDIESALDKVSLPDKAEATVKRLSANTQPIYQAAIFSEGDNSQALEEKLQEDVVPKLQKLNGVSSVSLKGTTSELLNIVVDKEKAAQKGITLSAIQSALQSLDYALPLGTVTQEETTIPIRLTGSVDSLKQIEDLKLGAAAAQPGTASSPQQQASGVALLSDIAEIKTVSTQDEITRYNGEPSFVVQVVKNQDANTAEVSDEIKELLTSYQDKGELNVHVIRDQGEEIKESVSGLIREGLYGTLFCVLIIFLFLRNVRATLISIISLPISIFATIAVMNQMGYTLNIMTLGGIAVSIGRIVDDSIVVIENIYRWKQEKGEQLKGKELAFQATREVIGAVASSTVAMIVVFAPLAFVSGIIGEFFRPFSLAVVISILTSLLVAVMLIPVLGSKFFKRVKPHKQGGRLTDGFEKVIRGALKRKGIVLGASVLLLIGSLSLIPLLGVAFLPAGSVPTASIGITLPSKSGLEQTDKVSAKVESYLKELNETESYSVSIGSSGGNPLASSGGKNKATVTAQFVDGTDIDQLVDRMNTELPAIVTAEEEGTAINVKAGEQEGLVTGNNIDVSVFANNADNLAKAAQQIESLMKQSSDLKDITNNMNEVSPKWVLTLNQQGIDANVSPLLIMQLVGEQLRPVDAGTYTIDNKDRDITLSYDRQITSREELENVQVPTVGGLKKLKDVADITQQNAWIQVNHDDGKMYAQISGTVKKSDEVSAVTKKIEDNINSLSLPSGVEVTIGGGQQMIAEGFVNLGIAMVVAIGLVFLVMSMTFGGLLTPLIILSSLLFIPVGALGALFVTGQSLSMSGMIGMLMLIGIVVTNAVVLLDRVEKNRKSAGMPITEAIVEASKTRLRPILMTAFATMLALVPLALSGSSTSLISGGLAITVIGGLFTSTLLTLIVVPVVYELAWRKRKTKEAETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGW4</accession>
    <name>A0A398CGW4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DinB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01202">
        <property type="protein sequence ID" value="RIE01202"/>
        <property type="gene ID" value="D3H35_22660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="56"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="228" mass="26795" checksum="1381A2D94B527120" modified="2018-12-05" version="1">MNLEQRRTWNDNHKRLTGIILKPDEHEEAIDLFLKQHALLYSRAMDHSEYPTMEDDLLEGIKEETLRQYPVNAPDTRNSIVWHLWHIARIEDMTMNVLVNGSDQIFHTNNWFDKMKVNASHSGNEMETEEVAELSSTMDIEELLLYRLAVGRQTRDIMKSLRPGQLKNKVESARLRKLTEQGAVKDKAQWLIDYWGSKTVAGLVLMPATRHNFLHLNRSMRIKNKYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH36</accession>
    <name>A0A398CH36_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_23130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01282">
        <property type="protein sequence ID" value="RIE01282"/>
        <property type="gene ID" value="D3H35_23130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017461110" evidence="2">
        <location>
            <begin position="24"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="433" mass="46790" checksum="EFA1D7B6986F8498" modified="2018-12-05" version="1">MKKSALILTAISLVMSALLTACGDKNESSPSEQSTASNSPAASSSEKVTLSIGSWRVEDVEGYKKIIAEFNKANPNITVEFKPTADQEYNTVLNTALMTGGGPDIVHMRPYAPGSELGDNGYLAAINDLPGLNTIPADLLASSTGKDGKIYGVPIALNATQIFYNKKIFADLQLSEPQTWDELMKVADTLKSNKITPFAVGSKDGWILSLVHSAIAPGFYGGTAFEEQLLKGEKKFTSPEFVKSIQAMKDLAAYFPDNYVGLGMDDMRNLFVTEQAGMFIMGDWEIAVVESMNPDLQLGMFPIPKPDGSKPTVTTWVDGSFGVNANSPHKEEALKFLEFAASKSFGQLMASELKRASAIPGVPGVDELTSKVADNAVNHSTPYNILIHFDRGNPTLKTALQDALQAMYLNKLTPEKAAEEIQKNADSWFKPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHD4</accession>
    <name>A0A398CHD4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_29150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000058">
        <property type="protein sequence ID" value="RIE00318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00318">
        <property type="protein sequence ID" value="RIE00318"/>
        <property type="gene ID" value="D3H35_29150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="71"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="337" mass="37674" checksum="238AF45252C0521E" modified="2018-12-05" version="1" fragment="single">DPLYLIPAMAAVTEHLGFAVTSSITYDHPYAMARKMSTLDHLTGGRIGWNIVTSNLNSAALNFGWREQLEHDRRYDRGDEFLEVCYKLWERSWEDDAVVRDRQRRVYTDPSKVHDIGHEGEFFKVPGIHLSEPSPQRTPVLFQAGSSQRGRLFAAKHAECVFLNAMTPEETKYLVDDIRSKAKEAGRDPADILFFPRFVPVVAPTEREAREKFESYLEQVSTEGTLALLSSWSGIDFSAFGRDELLAFIERKGNGSQYIADYLSRASAERPLTVPDLAKLYAFGGIENVAVGSAEQIAERMIAFADATGIDGFNVAYAIRPQAFATSPIWSFPSCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHM1</accession>
    <name>A0A398CHM1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000051">
        <property type="protein sequence ID" value="RIE00609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00609">
        <property type="protein sequence ID" value="RIE00609"/>
        <property type="gene ID" value="D3H35_27505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="87" mass="9589" checksum="D0B954817C2CDA1D" modified="2018-12-05" version="1">MKENGKEFKSDWQSGGRTSCSSTIRSVLAGRSAFGFGDFAARIDSIFVDLVYRTKRTTTPVSVRGAQSSGQLLRLDVPGHYRDGEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHM3</accession>
    <name>A0A398CHM3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MgtC/SapB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_18940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MgtC/SapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02726">
        <property type="protein sequence ID" value="RIE02726"/>
        <property type="gene ID" value="D3H35_18940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="159"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="247" mass="27194" checksum="74BD24CC4C8A8E9D" modified="2018-12-05" version="1">MSMASSGIWHITYLDMTIRILVALLLGGLIGFEREVNNHAAGFRTHILVCIGSATIMLLSIYGFGDFAKELNVRMDPARLAAQVITGIGFLGAGAIIRTGSYVSGLTTAASIWVVAAIGLCVGAGFYYGAALVTFLVLVSLFIFNKWEKYLLRKFRKHEMSIEIYDRPGLLGELVEKLSEQGIQISKMSVQPNDEKEERKRTVLVRFNVKVPQADRMVRAIDYITAFEEVLSIELPAFSGYSKAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHW1</accession>
    <name>A0A398CHW1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_14215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01925">
        <property type="protein sequence ID" value="RIE01925"/>
        <property type="gene ID" value="D3H35_14215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017482004" evidence="2">
        <location>
            <begin position="28"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="126" mass="13246" checksum="905F396EFB247722" modified="2018-12-05" version="1">MKKALRGMTAGASALLLFLLLSVTANAETGSGSAASPEPTATLPACHYMPPDDGQPIQVATTKTKTIQLSQTDSAVKSSDYENGAVKSGGLDTDGWQSYAWAWGAILFIVVGVTGRAWFRGRRGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHX6</accession>
    <name>A0A398CHX6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02856">
        <property type="protein sequence ID" value="RIE02856"/>
        <property type="gene ID" value="D3H35_19710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="105" mass="11751" checksum="9639D5CB6AE13326" modified="2018-12-05" version="1">MKNIYTNIILTAMLLCLIIIAIKDKNNITLEPNPVPEVVVNSSSEFVQIAPTVIGIKDNGTHTGIQGQLLIFELKGDSKTFTFRGTLNYEDYMNHPEKYGIPIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI24</accession>
    <name>A0A398CI24_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01662">
        <property type="protein sequence ID" value="RIE01662"/>
        <property type="gene ID" value="D3H35_22370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="42"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="153" mass="17117" checksum="9F1E2B41B504F424" modified="2018-12-05" version="1">MRKIHNINSIPDEFIGDYLGKASTMFLGGAAGSEKLYINIDKIQPGAKSAKYHTHSKQEEFFIILSGNGTLRMNGEELAVSRGDFVAKPAGQGNAHQFINTGTDVLEILDIGTNETGDVVHYPDENIYYLKDQNLKFKQQDDLREWDTEPNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI61</accession>
    <name>A0A398CI61_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_15345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02130">
        <property type="protein sequence ID" value="RIE02130"/>
        <property type="gene ID" value="D3H35_15345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="607"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="679" mass="76497" checksum="F23185AE8B4ACFAA" modified="2018-12-05" version="1">MGQTIGERMNEWMERRFVGRRFECDVFGQLLSAIHSRTERIINISGTAGMGKTTLLDRYESLALAQGAHSLRIDIAETGSGSDRIWRAVFEGLGRSAEQEAPASLEACISAIHRKSENGMLVLFVDSYEKIGSSDHWFRTAFLPRLPMNMLIVVAGRYSLEGPWRHSPAWKPLIIRLPLTELSYEDIHGYLQESGETDDEAIDAVWFRTLGHPLSLSLLNSSDGGDKAMQPLFSFEDRLEVWLREAPEEELRQLLFAASITRSFHQEWLSALLEKEVASTWFEKLSKLSFVSRASEGWQLHERVWEAMRRTFRERMPDTFERYCGKAVGRCLAKIEEGIRQGRDISREFAEALRFAGNPIMRAHYRHARESRHYMEPVDAGNREEAAAYAARRRDEARPWTVRCADLESGALFRYDLTAEESLLRLNALPIDELLEESPGALKLIRNAAGIVVGLTALIPIHEGTIDYLMRAPLSRAYFQSLSPVRRQELRVAPEQSSGVFVYSIDVDNLEDEELRGDIIPILFEPLLAGSLLVQSPPPLPYFAQACESLGFEETPGARHTGYGDEKVALTYALDTRKSRLPSYLRRMISDSGSLATAETMSDQSTISQLPERLTAREQEVAALLTQGFTNPEIAARLYVSEAAVKKHVNAMLSKFNLKNRTQLAKLILDGGSPDPFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CII8</accession>
    <name>A0A398CII8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Galactitol-1-phosphate 5-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_21260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03106">
        <property type="protein sequence ID" value="RIE03106"/>
        <property type="gene ID" value="D3H35_21260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="4">
        <location>
            <begin position="10"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="346" mass="36859" checksum="5037ECEF77B1AE18" modified="2018-12-05" version="1">MKAALIREVESVKKIRIEEAQLPELSSEHHVMVNIGAVGICGSDLHGFYDPKSMARIPGLIMGHEAAGVVTEVGAAVTRVKVGDRVAVDPQVICGECAQCKKGYYSVCDNKKIIGSNLKGFMNGCMAEFAVVTEKQCFLLPESLSLEEGAMVEPVSNAIHVLNRVKVNMGDTIVVIGAGTLGLCIMQAAKLTGTGRVIVTDLSEKKLALAKALGADIVIKADEDPVARILSLTDGLGADIVIEAVGIGATYKQAIAMVRKRGSIMFFGATHKEVSLELIPILHKELHLIGCTGAETECPVAIDFIASGKINVKPLISHRFTLDDTQEAFETMANPENDAVKVMLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIP0</accession>
    <name>A0A398CIP0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02603">
        <property type="protein sequence ID" value="RIE02603"/>
        <property type="gene ID" value="D3H35_18140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="609" mass="69221" checksum="608698B7202019AD" modified="2018-12-05" version="1">MSSDNSSRRMGSAPSFAHLRRLTDDTGLLEHALGRVPRRREGYTTDDNARALWTVTEWLSLASHRKKTDTIVGRRTNDSGTAADLARDDQAMEFGPDEDRSRNDRAMEVRSDEDRLRNDRAMETRSDEDRLRNDRAMGTRSDEDRLRNDRAMETRSDEDRLRNDRAMETRSDEDRLRNDRAMETRSDEERLRNDRAMEMRSDEDRLRNDRAMETRSDEERLRNDRAMEICAEKDGKMTAEQAGTLSALAEIYMAFLLWSQHDDGWWHNNIAYDRTPEPEELSHDCQGRAFWACADAWVRLEGPLRETARIMIEKSLQTIMRIDSLRGRAFAMAACAHLLDADESGTIQLPDDWRQLLKQQMKRLEQLMNEAFRHFADDSWRWFEPAMTYSNGIPAWALLRTYRVTQKPETLKNGLDSLAYLLDTMTAEEGWLRPVGNDGWCTNETISRWDQQPLEMFKLALALEEAALAVEAARYDESRLVASGVSSTLGTSGGSDSANSGSLGSSRHSGSSGSLGSSRHSGSLVGASWPGLVQSHRGSDMADTRYLREMRDLCLSWFYGENDLQVPMIDCSDGSCCDGLAEHGPNLNCGAEAAISYLMTEAICRRERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIQ3</accession>
    <name>A0A398CIQ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_16135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02260">
        <property type="protein sequence ID" value="RIE02260"/>
        <property type="gene ID" value="D3H35_16135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="42"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="103"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="167"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="3658" mass="386228" checksum="9AB2A51E62409876" modified="2018-12-05" version="1">MVKRIIRGKWNGFLLKWMLIASLIVGLFAPAGEGARAEAAASLPGFDVPADLLGHWAKEPMTEWVDRGLLKGFPDGTSRPDEIITRIQFVALVNRLFALVGDGKAAFSDVPIDAWFASDVKAAAQAGYIRGFPDNTFRPDKPLQRVEAVTMLTQLVPTIADEAANALGAFKDNTDVPGYGLVSLEAAIASGLLQGYPDGTVRPLKPLTRAEAVSLLDGIRKRSVPAANGGIVPNARALTTAGAYGPSSGEFTVGGNLEINAPGTTLRNVIVKGDLTIGKSVGEGDVFLQNVVVRGKTFVNGGGQNSVHIDNSELGAVVIEKTDGRIRIVVGGTTVIEQMDVRTDATIESPNSGIAGITISSSGEVTLSGEFKNVEIKDDVKLTVASGSIESIVVGEEVTGSKIRLESGVNVVNMTLHGATDVTGAGTIETAIVDSDKVSFEKEPAKKEVTTNGGSQGAGGGGTGGTPGPTPTQTPEPTQSPEPTSSPEPTQSPEPTPTPDIAVVASVSQSSATGFRLALSVQVAGLSASDITLRDAANQPVAVATPTTLDGGTVYRIPAVLTEGAVYKLSISKTGYSFGAETAFTVPVTPPPLVSVTASVYGISSEGFTLALNGPVAGLTSSNFTLVNKIDNTPISFGESSTGDGGSYVFDAELSEGQTYTLSIAKTGYSFGDAITIFVPVSDPEIIAVNAAITASDTEGFAVSLNPPVAGLTASDFTIVPDGGGAPVQATGTTTEDGGASYSVEAALAEGTSYEIAIAKTGYSFGASLTISVPVGDINVQPTISRISTAGFVISLDKQVPELDALNFVLTDGAAEIGVDMLSPIREGAEYEVWSRLAKGGTYTLKLDKEGYSFANGTVELTVEPTRLQAETAWVARTGFKLRLPNAVAKLPFVSYELKDESGNPIPVDAVKTEDGGRSIVFQADLSAAGNYHYRIDIDDDHYIEGIAAVPEAIPVSKYTTFEPSNAGIIVYFNVPVPGLALGDFQLTDTDGNSIVIDAATTADGGNSYYLESAAMQYQRLKLAIAHEGYDFGAPVFLIRTTLAQSYVGVGPNNFLAGLSPAVPGLTADNFRIVNASGESVPVENVAWYSFQGYYIVSYGGLRGQSNTVSVVKEGYDFGESKSITLEPEYKVTDISYGGFTFVLNPPTAINTVNGFEVKRSNGTVVNGIAVSTSDGGASYQVAANLTPGDYTLRVTASLGRTSFPFNVPVLATISADQVTNTGLRVSLNFPLDGLQPYQFVITRADTGEEVGIQSATTTDGGRTYRLVAELTGGQYKLKLTGHLPAEGVAFEAGVTIDAEAKEIANISNNGFDLVFGQAVPGLLPADLDLRDDQGVRVDGLSLTTLDGGATYRVSVKLTSNKDYTLSIRKDYVKFGSPIVFHVPIFVKGSIGEVTSGGDVSMSFDPPMPRIQDYGNMIVFKDASGNIFNPYLYQTLDGGANYLFKFAGEDALQQGTTYTVELNVAGHAMSPVSFAVPAGYSVSHASAAGITVAFDAPLPGLLKNQFVIRDASGADVKIVSAATNDGGGSYVLTASLTPGKFYTLQVKPGALYQQYKPITFAVTKTITATISELKQDGMKLTFSERVTDLKPSQLVFRDGSGTIIPPNLYAVSISTKDQGLTYQVRFGSFGSNDLSLDLNREDYNLAAPIAFSIPSLGSIWLFGTFAGQIIFGINPTPSELTIANVKLTDSKGKTVAAALAYDSGPYYSLLGDFEADETYYLAVTYPGFDFGDPLAIGMQIKSDAWMTGENQDGFVLRLFPPVPDLAPSDISVKDETGGTVAVQSLQSTDGGLTYKVEVPLSGAHAYSVSIEKAGYLVRSTQTLSLKSRSAALDRISIGGMTLNLSSKTSLNYTDIVLFDDSGNAVPTVSFASWDGGYSYEIGASLQTDRTYTLKVAKAGYDFGAPLSLFIKSVQTGYGGMASDNKSAFLLHFSEAVPDLRAGDFRLKRASDGRVLPVLIASTEDGGFTYKIEASFWGGERYTVVPLKAGYDFGNPVFAEVPVFANAALLGAGLSEFVIGMNPAVLSMNAGNFSILDGDGNAIPVLGVVTDDEGETYRVQANFRGGETYHIAFVRAGYVIEPSLSVTLPTTIASEILSAAPTGIRIGLTPGVAGLSKDAFQLKDSTGNVVAINTAISNDGGFSYWLEAELEGGKTYSLVLAAPGYVFGSALSAYVPIKVGKSIADPESIGFRVALDSPVPGLSASNVILLDGAGNTVSISAVETTDGGGTYTVRAALIEGEDYSLHIVRQGYDFGEGMPFVVPVPPLPEPEPLVAMTTSDAYYLGFKLHFSAPMPGLTKEWLRITDDQGQVITPNNVYGIYHRVDENNGWTDEQNFQVLMSMAVGKVYTVELIEPDRQSEGPIEVFEPLAVYPKLESATRDGFMIRFQNAGPNELQAENISIYSVDDTDAEIAVTSVTTGSEAGTYLVRANLAEGSVYRVELNKKAYDFRWNSNQLYVPIKASAAAARVNENGFDLVMSTPLPGLSIKLYSNINVSGFQPNSFVSTDGGRTYQVGIPFPYNSNYRVRLAKDGYDLGGDLVVEHVSLPPALLTAATDPGGRKIVLSFDKALSLVEENAPFSVKINNQWQSGVRAARVNGEPTKVELTWNASGAAITSTSAVRVAFGGVNRVQAVNGAYLVPFGEFEAANVATFEGFVRSFPTDQYADPLAKALRETYGKTALETIKLLREAGFARWNYSRAVKNEYGLDTAGFIALLFQMDADASMLFASLNDIQVQSSYTDLTGAMIAAGYEASDIAPQLRDKGYQAKQVSLSLKQAGVSASDIAAVLNETFRASADGAAAMLKGNGSNISAVGNAVQSVFGLSNADTIKAVASAGFTASEAETFARQRYSASGTEIASWLIGAGYAAADIGTALGASDPFANASEAAIALHGAGLEPTKLYAVVRGLFDGSSAANAMLAVDIPAGPVAEAVHAAGDAPKVVLSALLASGVDVKVAAAHVADAWGSSPSALASAMSGLASNGVAIAERAGLLREVYGANIASAIAALQHGATATESNAMASVLIAGGYDGEAVVSYFLINVYKGNRIVTYNLLRESKLPSDESLRLIRSAAVAAGNEFTLKDAVTVMIQSNESYAADDVLKALMTAFVQTEEDEIGAKEFAKAMSDANRWSSLDIGKSMIKRLGITLRDWIDLERSDVFSKQGCPCSVKTIAADSKYLFRGTTIEDITAAMSQSQYFTLTELIEGLVVHFDVVRMDALPYLTAALKNSGYPFTDIAAAFDTMGWNDWIWSFSRNGIAASEVAAYLKSVQLADDEIVQRLEPYPLNAIALTLRTELGKQDVEAAALLKSRYEDQDVANALAFVFGGDPAELWIKTLKSQNATAVTAIKTITARFPYYRNADVVGPALVRGGYGMDEVMTGLMFLTNLYGNLKATVSLLKEMYSAEQVSISRLLSASGSDTPESGIMFLRNAGFGIAAIARGLKEHYGLASGKTSGLLAKAYPNNIGDVLNAVTAAYGEDRGQTVVGVLEEQGITTLEDAMTYLSRKGYSFAEAVGAVKDAFGLSPGETAKRISAMNISSPGVLLTTISSVYKQSMLDTVYQRQIADGTANFQAAIEIAYGAGLSLAEMVRMAKDNYGISSGGGVPGFDGFASVYFFRDHDSHFDYLRDRRERKHCGFLASQRLDHARRRCLLFAKQPLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIS6</accession>
    <name>A0A398CIS6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLP-dependent aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_16270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02280">
        <property type="protein sequence ID" value="RIE02280"/>
        <property type="gene ID" value="D3H35_16270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="51"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="403" mass="44575" checksum="E4D078F315CF1F3E" modified="2018-12-05" version="1">MTHTPANTQPYPFAKRVPAIPPIGAAQASSRSDTIPLSFGAPHSDTFPYDALNDAASEAILSQGRDALQYAGASGPSFLLDWIAARSARRAINVEPSQVLLTYGSQQAIDFAARTLLDPGDHAWVEAPTYFGAVSTFRTAEAVLTSFPIDADGLQTDEVEAALRAAVKTGKPIPKLLYVMPNFHNPGGVSLSLERRKKLAELAVEFNFFILEDDAYTELAFEEQALPSIYSFAPERVVYLSTFSKTIAPGIRLGWAIGSRDVISRMNTFFQGSKASVFSQEIVAQLLKKLPFEEHIAKLNGLYRANRDAMVSALKQYFGDDVRFEVPGGGFFVWLEFREDVDTSQFVQDAYERGVSFIHGKQFFVKPEGARFARLSFSYCDEERIHNGVKLLADAYYAYVDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ80</accession>
    <name>A0A398CJ80_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03366">
        <property type="protein sequence ID" value="RIE03366"/>
        <property type="gene ID" value="D3H35_11850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="104" mass="12067" checksum="4EAF835FBD14DEBF" modified="2018-12-05" version="1">MKSKVNRYLYNLGLGIFVLFIIFVILSSYVEKDGSYTITIYGEVPEKYISEIKDPNHLVNGYGLNVPDERVEISAKPFYVLFKKKGREILLVTNNVNKLNEYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJD3</accession>
    <name>A0A398CJD3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_19405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02803">
        <property type="protein sequence ID" value="RIE02803"/>
        <property type="gene ID" value="D3H35_19405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007892">
        <property type="entry name" value="CHASE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05228">
        <property type="entry name" value="CHASE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="303"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="377"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="662" mass="70673" checksum="15B343A3305B0561" modified="2018-12-05" version="1">MRNLNRKSRFGAGSLRTQVLLMMFVVLMVPLGVLGGVYYSTLSSDLRDIEWSHALEIDSSAHKLTEQLGEQLSASVITNAKWEDNRAAVEAKDTKWIKENVDVSKGIIPNVHFVVTLDNDGNVLSQAGDLEEFTKKVAVGELFPELKKKPDVYGMVRTSKGLAVIAVSRITNEEKDKPSPGLLLFGRVMDDAALQGVSSLLNAGVAIRSKDGQTLASDEALPAYLGENAAPAEPEFDSVTVNGKQFSHVTSQYGLMTGETASFIVSVPAEASSTVRTELIRMSGIAGALAVVLIGLIAVMIRRRIVLPLIRFKLFLGGVTEGKLSDELSVKDTRRTDEVGSIARSLQEMTGQLRTIVSGIRSTASVTAESAEELSANSEQAASGADQIADSMRELAAGADSQREGMKRGAEVTIQIRDGIWTIGDRTTSVAAVAEQATKHAQDGNETVKQAVEQMGTIARTVESSVRDARELHEKSKSIRGMADAIAGIAYKTNLLALNASIEASRAGEQGKGFAVVAGEVRKLALQSNETAAVISSKVEEIRAVIEAVAKRIEEGFVEVQSGTELVRQAGGTFQDIVGGIADMEAELREIASAGQEIGARIEELAALVEETEAISEASADRSQEAAGIAEFQSNSVRGVADAMGSLTQRIAELERAVNRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJD8</accession>
    <name>A0A398CJD8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdenum cofactor biosynthesis protein MoeA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02465">
        <property type="protein sequence ID" value="RIE02465"/>
        <property type="gene ID" value="D3H35_17350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="1">
        <location>
            <begin position="26"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="184" mass="21256" checksum="36903A37A10B633E" modified="2018-12-05" version="1">MKEIWIRLERWLEEEAPEILSDLNAGATEAEIAALEEATGLQLPSDLKESLNIHNGQNGEGQWLFAGWEFLSTERILDEWKVWKELYDKKSFDSWDVDAESGIANEWWNPAWIPITYNGSGDHHCIDLSPTKDGTIGQVITMWHDSDERRIVASSYRQWLELIVAKFEANDSEYVFDSGDFEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJE6</accession>
    <name>A0A398CJE6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_17400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02475">
        <property type="protein sequence ID" value="RIE02475"/>
        <property type="gene ID" value="D3H35_17400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="323" mass="35747" checksum="918664E7772BFB37" modified="2018-12-05" version="1">MVSIKDIAKKAGVAVSTVSYALNGSDKITEETTARILAIANEMNYVPHAAARSLKKQQSHMIGIFLTDFGGHFYGDLLQGVKEGLNRKGFDLVVCSGRQSRRMIPERMIDGAIILDETFGDEELLEYASRGHKLVVLDRDLDHPNINQVLLDNKAGASLAMEYLIDQGHDKIYVVNGPKGSFDSKQRMHAVKQAVDRTPGVTFVELPGNFDKAAGEAAARRIADEYTRPAAVFCLNDEMAIGLYDYVQNNTSLIIGEHLHPIGFDNIELSRYVQPRLATIDYSMRKWGALASEQLIKLISGQPVDHERIYVTLVQGESVKTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJG5</accession>
    <name>A0A398CJG5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00978">
        <property type="protein sequence ID" value="RIE00978"/>
        <property type="gene ID" value="D3H35_25815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="237" mass="25579" checksum="4FA0ECBDB18FC8DD" modified="2018-12-05" version="1">MAYSYNNWFKIIDKSAVLPVILNKRFAEQDNGKLTLEFRFKMSAAMAGVKWQLRGDELEGVSIVADNTHLSIETAGGQASILQPYSSGIEYGIKVVADIGANSADVYVNGALKASSAPFKQPLATLNNFQAQTGSGSMGELFFAPVKLYKGYVVNERFLSVTPGTLPGDWSAAGGGGAISVEEMVSSTRPDAFSLKLDAANASNDMSFSTSFTPQSDDLIFEYKMLIPKKRTGCRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJI8</accession>
    <name>A0A398CJI8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_16395</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02302">
        <property type="protein sequence ID" value="RIE02302"/>
        <property type="gene ID" value="D3H35_16395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="7">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="8">
        <location>
            <begin position="97"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="203" mass="22149" checksum="251309ACD8BD6221" modified="2018-12-05" version="1">MAHELPALPYATNALEPYIDQATMEIHHGRHHNAYVTNLNKALESAPELADKSIEALIADLNAVPESIRTAVRNNGGGHANHSLFWTTIAPNAGGAPTGALAQAIESELGGFEKFKETFAAAAATRFGSGWAWLAVSKDGKLKVYSLPNQDSPIFEGDTPILGLDVWEHAYYLNYQNKRPDYIAAFWNIVDWNKVGALYEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJK5</accession>
    <name>A0A398CJK5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="7">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ddl</name>
        <name evidence="11" type="ORF">D3H35_16520</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02322">
        <property type="protein sequence ID" value="RIE02322"/>
        <property type="gene ID" value="D3H35_16520"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="167"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE02322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="391" mass="42488" checksum="7563AE9E97037D39" modified="2018-12-05" version="1">MNKGNKIRVGLVYGGRSGEHEVSLQTALAVLKAFDFDKYELIPFYITKTGQWRAGALLAAPPASVAELQFANEGAAEIGASETGEDKGQGPGTGELFPVLLQGMSEQALTNGVAADEGRPIDVMFPLLHGTFGEDGTIQGLFEMAGLPYVGAGVLASSVGMDKVAMKTMFAHAGLPQVGFRHFNRFGWKSDREARLNEVEELGYPCFVKPANLGSSVGVSKARDREELASAVELALRFDRKVIVEEFVDAREIEVSVLGNDEPIASVPGEICSSNEFYDYKAKYIDGKSAMVIPAEIPPETAEQLRSMAVRAFLAIDGSGLCRADFFLRRSDGALFINEVNTMPGFTPFSMYPLMWKESGMSYRQLLDNLIGLAIERHEERQSIDYTGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJU0</accession>
    <name>A0A398CJU0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_20385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02963">
        <property type="protein sequence ID" value="RIE02963"/>
        <property type="gene ID" value="D3H35_20385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017369825" evidence="4">
        <location>
            <begin position="30"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="5">
        <location>
            <begin position="93"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="530" mass="58180" checksum="401BAE6C81CF2BE7" modified="2018-12-05" version="1">MKNLFFAALLFVIITTSACGNNTNSTNDAAGKPSNGTGTEQASAGTDKPNDQELIVAGQEIAASLDPVQPLTSSYLRNIGAAEALFIVNAEGKVEPSLAESATEVDPTTWEIKLRPEARFWSGKAIDADAVIASLERSKALDLQAKPFLEELTFAKADDYTLRVKTKRSHLSVPLNLSYYQTVIHNTAAKHDAVPTMDLSGMYKVTEFIPKQKLVLEKNESYWGKKPKIQRVVYEEISEEQTRVLSVLSGRSQVALNISPSSLAQLKDSKEAVLSAVPAANTQTIYLNLSRPQLKDVRVRQALSWGLNREDLVILAAEGQSFPVSTWLSSNPAYAEARNAVYAKFDPEEASRLLDEAGWKKGSDGIRYKDGKPLTLRLMTWGGDKALGEALQNQWTGIGVKAEVQHGDYSLIETARESGDWDASIEAWSTFGDELSLLTGQYAPEGRANYGGYNDEETNQWLSQLAEASDEAARHSLALKINERVAQQAPVISLFPRPQISAISSKLHGFKEHFRQFENVVNADLTLDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJW8</accession>
    <name>A0A398CJW8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000035">
        <property type="protein sequence ID" value="RIE03606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03606">
        <property type="protein sequence ID" value="RIE03606"/>
        <property type="gene ID" value="D3H35_10730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="100" mass="11602" checksum="EC4F9F4259D56306" modified="2018-12-05" version="1">MGLVSQLFLSSNRLHAYRSQKTERQLQRTDRGQEIHLSARPLERPVQIAAEPGIDLSRFVLSVDLIDPWFELRKIQVISRADYQEDDIASIHVTLEYGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK67</accession>
    <name>A0A398CK67_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_29380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000061">
        <property type="protein sequence ID" value="RIE00287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00287">
        <property type="protein sequence ID" value="RIE00287"/>
        <property type="gene ID" value="D3H35_29380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="283"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="558" mass="59997" checksum="13FB13DC361019C4" modified="2018-12-05" version="1">MPNNSPKYRDVYLYDAAKDEMTKVSRGPDGKGGNNNSYYPAISADGQYVAYLSKASNIVAADTKSSQDLYVYNRLNRTTELASVDSGGVQPGVDVYDPSISADGSYVSFHTDGAFDPADAGRTDVYIATESGRDALDQQDSRRRERRSTGRQGDAERRCRYDCVRDESDEYGSSSDPDSFIDIYAAALPSGASAPIGLRSRRDGSIWCRLCVVKLARSRRSRVLQGDAGRSGRRHRDRRIVRGGRTEAGTEHRYRIAAGSSGYAWSDGRRSDRNDIGGARDDAPGRTTANAAGVLGGAQVSWVYPSDPDVVGAKVFWRKTFGAAQFGPTRESVLYPKSVASALVPNLENGQFYEFAVAIVDGDGNRSVSEWVRIKLPAGPAIVRLDVRASDGRPAGSDTPRIADISGDGRYTLFLTEAQGIVPGDDSVNPGDSYTPTTDLYLFDAELGATQLISRTPGGKSANSNSNGGSISDDGRWIVFGSRASNLTETADTNGKWDVFLYNRDVNGNGVYDEEDDTSLTKISTPLANNGQANGDSSGLLLAPTAALSFSARMPSIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKG2</accession>
    <name>A0A398CKG2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_28575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00377">
        <property type="protein sequence ID" value="RIE00377"/>
        <property type="gene ID" value="D3H35_28575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="68"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="272" mass="30536" checksum="7844A16C4C6BE055" modified="2018-12-05" version="1">MTRRSSVIALEIVAIALALLILIPFFMILVNSFKGIRESALFGLSLPSTWEFGNYKDVLKQDNILRGFKNSFLISGLVVVCVNVFAAMCAFVIQRRGGKFLQGVYLAFIMGLIVPVSIVPTIKMMDALHIKGTYFSIIMYYSAVLLPFAVFLLVGFMKSIPRELDEAALLEGCGYFRLFFRMILPLISTVLVTVSIVVIVSVWNDFFGPFYLVTDSTKWTIVLQVFNFVTLYSTNWGIVFAFMIIVITPVLVIYLFLQRYIIDGLTAGSMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKK5</accession>
    <name>A0A398CKK5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02830">
        <property type="protein sequence ID" value="RIE02830"/>
        <property type="gene ID" value="D3H35_19555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="98" mass="11090" checksum="8CA0863C2F0EC88D" modified="2018-12-05" version="1">MLDLRHPRFLFAADDGRALDLRHPQFLFAADAGRVLDLRHPQFLFAADDGRVLDLRHPQFLFAADDGLPVLRIKGNLSSNKTMAKKQTLCLCHNPIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKN7</accession>
    <name>A0A398CKN7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_19730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02860">
        <property type="protein sequence ID" value="RIE02860"/>
        <property type="gene ID" value="D3H35_19730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="55"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="292" mass="31896" checksum="C16A4C53F958EE80" modified="2018-12-05" version="1">MAKKTVNRRGRSPAAGRGKFAKKRIRAKKAALPKSNTGLEETTEAVISRPSPSVSVIVPVMNERRTIRRVVQEAFRVHPRTEVIVVANGSTDGSAEIARRSGAKVIAYDKPLGHDVGRSMGAREAQGDILLFIDADMVIPAVKLRPFVRQIESGTDVALNDYSGPVDTTVVHGVVLAKHALNSLLNRSDLAGASMTAVPHAISRRTLQTIGYAALAVPPLAQTMAIRAGLQVARSIHVNVGKLNPLRVKRERTRSLEPLIVGDHLEAMNWWIDNSDYRGGYDDGARDRWRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKR0</accession>
    <name>A0A398CKR0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_20395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02965">
        <property type="protein sequence ID" value="RIE02965"/>
        <property type="gene ID" value="D3H35_20395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="70"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="275" mass="29650" checksum="F869DDC9F10C0A1B" modified="2018-12-05" version="1">MPDSNNPISFIFGLLILSLLAVSILGARWIAPHDPVKQNASERLEKPTVQHPLGTDRFGRDVLSRTLYGGKNTMLSSVFALCTALLIGLLTGLAAGMFHGAIIDRLLMRLIDVLLAFPFMVLAMVIAALFGTSLIHLLIAVVSVWWVSFARLTRSVVLHAKNETSFAAAKVLGATSGTLIFKELLPKALSPVLILATFELGSLILSIAALSFLGLGSQPPTPEWGSMLADGRDHFMQAPHILIGPALFIFLTVLAFNLIGEGLRDRLDPYEKSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKR6</accession>
    <name>A0A398CKR6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-glutamate methylesterase/protein-glutamine glutaminase</fullName>
            <ecNumber evidence="3">3.1.1.61</ecNumber>
            <ecNumber evidence="3">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheB</name>
        <name evidence="9" type="ORF">D3H35_11480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol</text>
            <dbReference type="Rhea" id="RHEA:23236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="3.1.1.61"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CheB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.61" evidence="3"/>
    <dbReference type="EC" id="3.5.1.44" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03303">
        <property type="protein sequence ID" value="RIE03303"/>
        <property type="gene ID" value="D3H35_11480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018277">
        <property type="term" value="P:protein deamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006482">
        <property type="term" value="P:protein demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16432">
        <property type="entry name" value="CheB_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00099">
        <property type="entry name" value="CheB_chemtxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008248">
        <property type="entry name" value="CheB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="CheB-type methylesterase" evidence="8">
        <location>
            <begin position="301"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3 5">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="499" mass="53744" checksum="C3C5FAF28FEC8D43" modified="2018-12-05" version="1">MPKYNVLIVDDSPFMRKVFSDVVDADEAFQVLATASDGEEAVELTVKLLPDIITMDMEMPNMNGLEALHRIMEVRPTPIVMLSAMTDNGTRDTIKALQYGAFDFIRKPDGSGKLDIHLVGEQLREKLHIAVEAVRKGSFRLLPASSPGGAQPVSALSPPAPAIAETSDRTDTNPDMATGTDTVKEKPIVIPEPAERRKADGVKPEDRIPTQDTTFKNSRFGRTALERSTSLGTPSIDKKPDPIPKAPARPADGTELKGRRVTTGARHQADPAPASAPVKKSVDPSRIEQKPHKSDEPKGKPMPTFNQVVAIGTSTGGPRALHEVLTGIPADFPAPILVVQHMPPKFTHSLAQRLDSFCRIHVREAVDGEPLETSTAYIAPGGKQMSITKDAAGKYRIKLTEEGPRNGHMPSVDVLFESLIGHKPLKRHAVLMTGMGSDGAKGMKALLEDGASTAIAEAESTCIVYGMPRSAIELNAATEVLPLPKIAQALVHEVKVRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKX9</accession>
    <name>A0A398CKX9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00547">
        <property type="protein sequence ID" value="RIE00547"/>
        <property type="gene ID" value="D3H35_27800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018513">
        <property type="entry name" value="Cell_synthase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39083">
        <property type="entry name" value="PTHR39083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03170">
        <property type="entry name" value="BcsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017378028" evidence="1">
        <location>
            <begin position="28"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="291" mass="32459" checksum="C7F9AEECD321FD35" modified="2018-12-05" version="1">MKRTASNWILMVAMIVVILSSQSAAYAETGAQSSSANESRSIFSEERVFRGENARQDSYFEIGKGLEARQGSSINIYYSHSETLLPEYSNLTVLLDDVPLGSVTLSKENEKETLWSIDLSNLSLKPGFHKLSFWGKMKVSNVICEDPENSAAWLVIHKKSAVALHLEQSYEKADLTQYPSPFIERGSPDPLRAIIVLPDKFNQDEFKAAARISRFFALQTPNHRLNVPVYVESDVTDALARSHSIVWIGKADRWLAKGKSVTEAFAQSKDADQLAKGLSAKRLHPGMPKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL09</accession>
    <name>A0A398CL09_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyl-accepting transducer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_21115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03085">
        <property type="protein sequence ID" value="RIE03085"/>
        <property type="gene ID" value="D3H35_21115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="3">
        <location>
            <begin position="37"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="193" mass="21593" checksum="A9055E3DDB6C10FA" modified="2018-12-05" version="1">MVRQTNSSAKEVLDTATSLTDASRKTPKRLRNRHRYEEIANGATNLAFESEKGTDMTSEIGTQVQTVIASNVEMGNSANEVEEASRRGSDYMDTLINKTGQTEEMTRSMVEKVDKLKDSTRSIRKNSRCARQYDEADEHLVVERHNRAGPRGYAGKGFMVVADEIRKLADQSRQSIGVVAKSSKRFSAKSTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL17</accession>
    <name>A0A398CL17_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureF</name>
        <name evidence="4" type="ORF">D3H35_21195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03095">
        <property type="protein sequence ID" value="RIE03095"/>
        <property type="gene ID" value="D3H35_21195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="243" mass="26769" checksum="E8AE0C86C5EC22FA" modified="2018-12-05" version="1">MSAGQWLSLQMLLDSALPIGGFAHSYGLESLVQDGLIADGADLRRYAEGMVRHSWAVSDLMVVKAVYAGGGSGSESDSESDGDWRELDWPYAFHIEKLVHLQRIAPETRDGIEKTGRRLLRLAPELFPRLDLRMLGQSVRSGECSGTFPLVYAVICRGLDVSFEQASEGYLYTSVVTCVNAGLRLISMGQSEAQRMIASLLPVIRQARESVAAMNPEDAYGAMPMSELAMIRHETLYSRLFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL65</accession>
    <name>A0A398CL65_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03403">
        <property type="protein sequence ID" value="RIE03403"/>
        <property type="gene ID" value="D3H35_12080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="209" mass="23738" checksum="0D96DDDDF69D6CD8" modified="2018-12-05" version="1">MTTENQTPEKTEEVEKQAEMMRLLTQVYQHSITAIKSGFPDNEVDGQIMNHEQFGPLLVFHVKNEQGHVYSCGFFLNELLNKFQKGTNAATYLSSFFVDLMETEGGKPLPQPPQSEDDVTHLIDNELIPHCRKAVQEEFEPEIIHIQLDLHEQYGPVLESGFQAITEGNNVCAVPIPILMIHYLLNRDPADIIINGLYRIRDEHGLGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLE4</accession>
    <name>A0A398CLE4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_14680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02009">
        <property type="protein sequence ID" value="RIE02009"/>
        <property type="gene ID" value="D3H35_14680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="SLH" evidence="4">
        <location>
            <begin position="716"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="4">
        <location>
            <begin position="780"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="4">
        <location>
            <begin position="841"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="895" mass="95879" checksum="9388804E9A45E3C3" modified="2018-12-05" version="1">MRVNKQLDNRGAARKKHARSGKFIALGCVFALIAGSLTSEISLYGESAATAGDVRSLSQANVLVDPGDTDKTVAARKPAFLETLGIPQAWSSFDGNVRATIAIVDTGADLSHPGIRPYLTDGVNLLQKGKPPQDDNGHGTAVAGVIAAIADAGNAGSGDLASKPRWQGRIMPIKALDQSGAGDEAKLTEGIRYAVEHGADIIVLSLGLRRDAASLRGAVALAESRGVLLVAASGNDAAEFGSKAAVQYPAAYPTVLAVSGATGDQAEARSTHGSETDIAAVWKVETLAIGGGRTSMEGTSMGAPQVAAAAAMLWGAHPDWTPLRVREALRRSAADLEPKGWDPSTGYGMVRVDTALRAKDVPDWREPNDTLAKASAFPLGKEVAGTWSGSKDIDSFLVRIPYDGTLVLEGSAEAVDWQSGLTLYSAGDQKVVRPLSPAHWPVRKGQSYWLKAAAPPLLKDGGVAAAAYRFVSTLKIGADSMEPNDSALSAYTLPARSQDWSGTFHQRQDEDWAVVTLPKEGTLRLAVTTDTTRIDPSLWVQPAGGTATMADENGDGEAEELILRQARAGKYYIRIRNESSENPEPVIGTYTVSLEYITKYEDPNERNDDALTATPLATGKIYNGLIDTSKDNDWFRFTIDGKREMNISMSNIERTAAVSIALKNQKLQTIHTWKNAAGKQELSGLTVLEPGTYYLSITANSPMSNGLYALKLTERSAEEPLWDIAGHWAEKPIRAIVKQGWAAGFADGRFRPDRELTRAEAVAFVVRSVDERETLGLPAKTRFQDLSSKHWAYGSISKAEKAGWLAMYGSSSMFQPDRPMTRGEIAILLAAAGSVETGRPTGQRFRDVPASHPAAAAIEALERKGWLAGYRDGRFQPDEPLTRAECAVILAHLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLF6</accession>
    <name>A0A398CLF6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000055">
        <property type="protein sequence ID" value="RIE00471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00471">
        <property type="protein sequence ID" value="RIE00471"/>
        <property type="gene ID" value="D3H35_28220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="160" mass="18850" checksum="DAB58E3B529A147C" modified="2018-12-05" version="1">MQEVKEVALQAYEHQEYPFEELVEKLNVRRDLSRNPIFDTMFSLQNMSEEETEIEEMRFSPYGFEHSASKFDMSLTAVETGREIGLSLSYCTAIYTKETAERLGRHYVALLRDISSQTEKQLKASNCLARKRSVSFCMRSTTRRRRIRRVKRFTGCLKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLH7</accession>
    <name>A0A398CLH7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">M42 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_21280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03110">
        <property type="protein sequence ID" value="RIE03110"/>
        <property type="gene ID" value="D3H35_21280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="362" mass="39420" checksum="25B4CD92BEA206FE" modified="2018-12-05" version="1">MNLTEILKILSLTPALSGYEHLMADRMKSFLSPYVDQIETDKMGNLITTIKGLEADAPRIMLFAHMDQLGFVVRKIESDGFIRVERLGGVPEKALAGQPIVIQTEDDRLIPGLIGNKSHHLTPQEEKYTVAGYKNLYVDIGADSAEEVYAAGIDIGCPVMYQPDFQPIMNNKVYGTSIDNRGGCAILIRVAEILKEMKPAATVYIVGAVQEEFNLRGAMVAAQALKPDCAICIDINIAADTPDLKDSNDIALGAGPVVSMYNFHGRGTLNGTIPPRRMVKWTREAAEAAHISLQRGAMSGILTDASYVQLVDSGIPTIDIGFPARYSHSAVEVCDMQDLEQVARLIVQMVQMAKPGAPFGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMB3</accession>
    <name>A0A398CMB3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn_Tnp_IS1595 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_26685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00781">
        <property type="protein sequence ID" value="RIE00781"/>
        <property type="gene ID" value="D3H35_26685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024442">
        <property type="entry name" value="Transposase_Zn_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12760">
        <property type="entry name" value="Zn_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_Tnp_IS1595" evidence="2">
        <location>
            <begin position="17"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="196" mass="22242" checksum="C3ED7B7CADE23762" modified="2018-12-05" version="1">MMTELPAFESFCHQYSSEQACAEALFHARWPDGFRCPTCRHSHYYLTRTRRMPLYECRSCRVQTSVIAGTIMEGSSTPLTRWFQALFLIASPSGISSSKLSKIIQVTYKTAWLIARKIRHVMQRADQYDPLSGLVRVNHMKYGYSYYQDAQQPLLIGGAFTASAQNIPSTDLIGSMSSTKTEESRPQLNNRIPTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMC5</accession>
    <name>A0A398CMC5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PIG-L family deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03400">
        <property type="protein sequence ID" value="RIE03400"/>
        <property type="gene ID" value="D3H35_12055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="223" mass="24456" checksum="ED53C1B874BD0F4F" modified="2018-12-05" version="1">MNQLGKTAFIYAHPDDESFLSACMIRRLADQEQAPVLLLATRGDAGGKNGFASQLTREQLGELREREMEAAARVLGLTAVSHLGIPDGRLDEADETEVASRIAEFANLHGARTLVTFPPDGGNGHRDHVAISRFTTAAVVSGRCETVRELYYVMSAGLAEQGIAPDMTIDAKPMWEMKARALWAHESQRLAIERYFGQGAAFSESRRYETFVVGWTAEGGLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMC6</accession>
    <name>A0A398CMC6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_4-like_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03803">
        <property type="protein sequence ID" value="RIE03803"/>
        <property type="gene ID" value="D3H35_09625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="43"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="250" mass="28284" checksum="4018F474F5C8D476" modified="2018-12-05" version="1">MPRQQAQEIVVVTRKGVRAECVSWMGWVVQLNILQVADHFGPFGGLEKFIYDFSRKLAGQGDTTAIAVIDKEERHDWGSETIDTALIPRDEEQWLAFAKRYRPDLIVWHTGPATASFVDRLSTLAPVIATVHSPVCPAGTRLFRDKDEICCHPTGAACLMRWYTRRCGTHPEPWLALEAMTRNGKMLKTLRSCDRVYTVSESLSRFIEIEGIKPDRLRIFDNTFGDGTGGARRCLPCKYRETRKSCTCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMD6</accession>
    <name>A0A398CMD6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="7">TC-AMP synthase</shortName>
            <ecNumber evidence="4 7">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_14505</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SUA5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="4 7"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01978">
        <property type="protein sequence ID" value="RIE01978"/>
        <property type="gene ID" value="D3H35_14505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="9">
        <location>
            <begin position="17"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE01978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="385" mass="40592" checksum="196426C4BE8ACFDF" modified="2018-12-05" version="1">MTTTQYWTASSTAERGEADLKEAAAALAAGGVVAFPTETVYGLGGDARSTEAVGKIFAAKGRPSDNPLIVHIADEADVESLCERVGEIERTLMRIFWPGPLTLVLPVRPGAVSPLVTAGLDTVAVRLPEHRLARDLIAAAGCPLAAPSANRSGRPSPTEARHVQEDLDGRIDGVLDGGAAGVGLESTVVRVLDGIVHVLRPGGVTAEHLQAAIGDLAEVRQSHGTEETNPVVAADDSAADSGISARELAEERLLPELRQAAEPPRSPGVKYAHYAPRGEMLLVTGDPERMVAEAQRAADEARRQGRRVGVLACAEHEARYRAEHVLRIGSRAEPATAARALYAALRQCDELGLDYIVAEGFPEAGIGAALMNRLRKAAGGREHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMI5</accession>
    <name>A0A398CMI5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_05680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04576">
        <property type="protein sequence ID" value="RIE04576"/>
        <property type="gene ID" value="D3H35_05680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="277" mass="31003" checksum="6EA4E32BC7A8F607" modified="2018-12-05" version="1">MKNSAGKGRAIYEVSFLSSIRARRYINKKELKFDRFPVDMLCFVTDGVGKLFIGDEMTEIGPMRLYYLPRGEAIKASVSSESVGLYLLAFEYFAGGKAAAERKGTRLSLLASRPSSLPRGSIRLRGTDRILNWIRQLYEATGSQSKGCRLQLLFQELLNGIAQEYEAGAERKSAQSGIELAIAHMKANFRSKLDMGTVADIANLTLSSFSRLFKKNDGRISDRIFDEASNGQRQKLALAKKVHDKKPYRRPSDTRMNSILAACFIGMSECRRLFTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMK4</accession>
    <name>A0A398CMK4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_03615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04596">
        <property type="protein sequence ID" value="RIE04596"/>
        <property type="gene ID" value="D3H35_03615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="155" mass="17463" checksum="89B3EF52D7F38D2A" modified="2018-12-05" version="1">MPSKQLREPMLAAKKLYDPYPVGVAEQEALADWMADGGYDRYMKRLRRSYGRLESMLRQRLEADLPGLFRIAPSDAGLHLYAIWLRDSESYGEFKRECRLRGVAWKDGTGYDAHSGSSSTAGAPAALFGFSHLEEREIEEGISVMREAAETIREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMZ9</accession>
    <name>A0A398CMZ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_08475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03983">
        <property type="protein sequence ID" value="RIE03983"/>
        <property type="gene ID" value="D3H35_08475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="20"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="272" mass="30792" checksum="743CF85169FA4983" modified="2018-12-05" version="1">MIPAYFHKYPKTLLNKGTGFLSGYSHSLNPYAGCSFGCSYCYVRQMPVSVFRGAEWGTWVDVKMGAAELFRTELQKAKAKGPVTIFMSSSTDPYQPAEHKERVTRSLLEAMADDPPDFLFVQTRSPLVCRDADLLRRLGDKVRVSVTVETDREDIRKHFSPYAPPINARLRTLRLLADAGIPTQATIAPLLPSTDKFAETLQTLVDRVCLDDYFMGDGSGGKRTRRMGIRALYEQLGLEEWYDPSAYRVVRERLLKVFPEDRVYISQAGFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN68</accession>
    <name>A0A398CN68_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_08875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04053">
        <property type="protein sequence ID" value="RIE04053"/>
        <property type="gene ID" value="D3H35_08875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="59" mass="6436" checksum="1A20178E28B789FB" modified="2018-12-05" version="1">MPHAGGEIRLIDGGVLLCPLHFWTFDSASGDCTSMPGERLLFRQVSVSNGRLIAFESDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN71</accession>
    <name>A0A398CN71_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class C beta-lactamase-related serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04806">
        <property type="protein sequence ID" value="RIE04806"/>
        <property type="gene ID" value="D3H35_04880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="314" mass="35222" checksum="A355AF1BEBF77543" modified="2018-12-05" version="1">MHPVSSPDSRFLDSFANEVSKAKIDYCEIRQGDAVLFAHCRDPHNPGKLHKVNSITKSVVSLLIGIAIDRGELENVHTAVSDYIPSCERQDLTIEHLLTMTDGWDWREWGDWGGLPKPMTGSPNWIRYIVDREIVHPAGRHMAYSSGSSHLLSAILQKATGMTTDKYAERHLFGPLGIEEYRWQSDPQGIVIGGFSLELPAADITKLGLLALNNGRWNGRSVVSSEWIGQSTRPLYLTYPHVGHYGYHWWVLPAPNGGAPRIPTVFFAMGYGGQFLYVVPEHRLVAAFASSLYKDSFLPHRLFLSQLLPAFERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNA4</accession>
    <name>A0A398CNA4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arg_tRNA_synt_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_21770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01061">
        <property type="protein sequence ID" value="RIE01061"/>
        <property type="gene ID" value="D3H35_21770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="6">
        <location>
            <begin position="2"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="58" mass="6649" checksum="A5897A34755B13ED" modified="2018-12-05" version="1">MIAHLDKSRRVIQSAEIAGPGFINFRLDKSYLYPLSRRFCSKGALWLGCGWRRPVRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNC8</accession>
    <name>A0A398CNC8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02749">
        <property type="protein sequence ID" value="RIE02749"/>
        <property type="gene ID" value="D3H35_19080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="327" mass="37583" checksum="7EFEFB730ED209A1" modified="2018-12-05" version="1">MDTGTHFVFGLGLGGLAMTDPVIASHPYGPIAVLIGTVIGSNAPDSDSLLRFKSNADYIKNHRGLSHSFPAIVGWTGLITVALSLAFRSIPWWHIGFWVLLSVVVHVFVDLFNSYGTQAYRPVSKQWVAWNIIHIFDPFIFSAHLLAIFMWITGAADPKVVFPVLYALLAVYYGWRTLVHRRLSRQVPSRDAKRRKGDRYTLLPTLSLYRWNVVRLSEDGTYGVGEWHNRRLQWFDVLKCDVHPAVEASKQHPDVKAFLSVTPFPCGHVKPHTWGYEVRWIDIRYRYRKQYPFVAVVMMDLSYAPLQSYVGWLSDERLDKRLRMNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNM9</accession>
    <name>A0A398CNM9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03850">
        <property type="protein sequence ID" value="RIE03850"/>
        <property type="gene ID" value="D3H35_09875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="72" mass="7415" checksum="CCD334F0F6C65C9C" modified="2018-12-05" version="1">MAGRAKDDRPTGLTIVHQTDSTIPTNGPLLAGTKPTPRVPGADESESFPMELSLPKSGPFVGIVGIGLMNDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNP0</accession>
    <name>A0A398CNP0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00524">
        <property type="protein sequence ID" value="RIE00524"/>
        <property type="gene ID" value="D3H35_27660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="247" mass="25185" checksum="B53B41AD0C0CB89F" modified="2018-12-05" version="1">MPIAPIGTLPGLPVAPIGTLPGYPIAPIGTLPGLPIAPIGTIPGYPIAPIGTLPGLPTAPIGGIPNMPIAPIGTLPGLPITPIGTLPGFPVYAAPVKHGCKPCQAPTPVWPTPLAASPLAVSPSSVGPAGVGPNGYYDGGYGSNVAAANVHVHAAHAAHAHYPYGAPTSVSPLSAAPVEYPYYSDQQHGLSSSSGYYDPKEPRLHASEEEDQLEQTTKRVSVKPKSKSSAARQSKPKRRGSLPWIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNT2</accession>
    <name>A0A398CNT2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_24840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01577">
        <property type="protein sequence ID" value="RIE01577"/>
        <property type="gene ID" value="D3H35_24840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025584">
        <property type="entry name" value="Cthe_2159"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14262">
        <property type="entry name" value="Cthe_2159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017259365" evidence="2">
        <location>
            <begin position="29"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="408" mass="41497" checksum="33BBFC1920209CB6" modified="2018-12-05" version="1">MKNKKLKSISAITLAALLTVSAVGCSKAQVGSEDAAATTQTATSTASSNATSAAGASVLDTSELFSDRDLEQSADLATATQMNLVSNQDVTLNKEGVYVLSGEVENATVVVDAAEDAKVQIVLNGVRITNEDSPAIYVKAADKVFVTSTDSENNMEVSGSYVADGDTNLDAVIFSKADITLNGTGTLEIVSNQGNGIASKDDLKITGGVYTIHSSADAIEANDAILISDGTITIDTDKDALHSENDEDGSLGNIYIKGGVLNITAADDAITGNNVVQIDGGTINIKTSEEGIEANNIKVNDGQITLYANNDGINATPKVNSNAAIEVNGGTIDVSMASGDTDAFDSNGDIYINGGTINVKAASAFDADGTAQLNGGNVTVNGEQITQITQSRGGGGRGGAGGGGRVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP59</accession>
    <name>A0A398CP59_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_02060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05176">
        <property type="protein sequence ID" value="RIE05176"/>
        <property type="gene ID" value="D3H35_02060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="314" mass="34539" checksum="673EBA41106FD982" modified="2018-12-05" version="1">MDIRTIKTFQTIVKHGSFQRAADELQYSQSTITMHIQKLETDVGLKLLERGKKLRLTEAGRLLNQKADVLLKDYDHLNSSMAELVQGEAGVVRLGVMEPTASYRLPAIIGPFLQQYPKVQISIQIGNTTVLHQMLEEDQVDWVICTTPDTGIGHLFEPLFVEKLGLLMPDSHPLAVKEAIYLRDLQNENLLVTTNVCPFRRKLESSLLEKGGSPYNGMEIGNMAALKFYVQASFGLAVVPYITAVPAPAGTVLREIEDLDSGLVTGLLRKESGAVLSSASIKLIECLREGLTKPLQPIDSAASPIFPSISSRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPN2</accession>
    <name>A0A398CPN2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_00050</name>
        <name evidence="11" type="ORF">D3H35_08955</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000001">
        <property type="protein sequence ID" value="RIE05490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04140">
        <property type="protein sequence ID" value="RIE04140"/>
        <property type="gene ID" value="D3H35_08955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05490">
        <property type="protein sequence ID" value="RIE05490"/>
        <property type="gene ID" value="D3H35_00050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="61"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="143"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE04140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE05490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="343" mass="38500" checksum="5792AD22D5E7262B" modified="2018-12-05" version="1">MRFVRNSKWEWTLYTGAISLAMALFFAWTETSDSPIEGKDWYGWAAGLIVLAMAVGYVLGRRTQQRIDQLQLAIKQAAAGNWTAKLPSLGMDAFAGVFLDFNAMLSALESRLKLLQQLGEKSVEEVSSQENAVLEERRRLARDLHDTVSQQLFALHMSASSLPKLLERDAEHAAKVMEQLIAMSSTAQRQMRSLIAQLRPLELQGRTLEEALDRWFPDYCRQNGLQGTLDIQLRSPVSEAMEHQLFLIIQEAMANVVKHAEAKVVRLFLGETDRQLSLNIEDDGAGFRAEQVRTGAYGLSTMRERAQKLGGEAEIVTKPGSGTRVKVWFPKFEPSTEKESTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPU5</accession>
    <name>A0A398CPU5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-xylosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_05665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04573">
        <property type="protein sequence ID" value="RIE04573"/>
        <property type="gene ID" value="D3H35_05665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gal_mutarotas_2" evidence="3">
        <location>
            <begin position="159"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="774" mass="86019" checksum="37D8C71D1D869EF6" modified="2018-12-05" version="1">MKFSDGYWMTREGYQVLTPYEVHDVVVGTNGITVFATHRHLENRGNTLNEPLMTMEFSSPMNDIIRAKFYHHKGQRRLGPSSFPLLSAGNSTVRIENNEDAVSLTSGDTTVTITKRHPISITYSHKGRRLTGSGTRATGYIKAADGNHHFREQLGLSVGETVYGLGERFTPFVKNGQVVDIWNQDGGTASEQSYKNIPFYVTNRGYGVFVNHPELVSFEVASEIVSKTQFSVAGEMLEYYIIGGDTLKDVLGNYTSLTGKPALPPAWSFGLWLTTSFTTNYDEATVTSFVDGMAQRDLPLAVFHFDCFWMKEYEWCSFEWDERVFPDPQGMLTRLKAKGLHICVWINSYIAQRSPLFDEAMELGYLLKRPDGSVWQWDMWQYGMGLVDFTNPAACEWFKGKLSALLVMGVDSFKTDFGERIPTDVAYYDGSDPQQMHNYYTYLFNKTVFELLEEKRGKGEAALFARSATAGGQQFPVHWGGDCEATYESMAESLRGGLSLGLSGFSFWSHDIGGFEQSSPPDLYKRWVAFGLLSSHSRLHGSTSYRVPWLYDEEAVDVLRHFTKLKLRLMPYLFGQSVHSAKNGLPVMRAMLLEFGDDPTCDYVDRQFMLGDSILVAPIFSPDGEARFYLPKGAWTHYLSGEQVEGGVWLTNTYDYFSLPLFVRENSLIPVGAEDSRPDYDYAQGVTLQLFSLQDGATATASIPTVTGETAFTASASRSGSTVTIDTQGAADGWSVLLRGVTSATSVQGGTAETGAEGVRIIPSAGASRLIIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ64</accession>
    <name>A0A398CQ64_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04665">
        <property type="protein sequence ID" value="RIE04665"/>
        <property type="gene ID" value="D3H35_04025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="415" mass="47340" checksum="433D6499BBAEEE32" modified="2018-12-05" version="1">MNLADMLCYADIEQLTRIADAYECDCSSHSKNELIQSILTAVQRRDALETRVGQMSKDDLRFLNSLLFETRATYSLEELKARAIGNAAGKEERASGSANSPMLSVPVKQALSPAGSRSRKKSASPELPPLEPDEIARLAITRFKRFGWLFNGISQQTRYLFQVPEDVKTRLCDTLERQFRTSLQITDEPPVYRDEQGLLADDLIRLLRYARDNDAPLTSEGILYKRQLGQLLELMSIGEQVPAKGGWRFGYGRRIRDYPERFSLLYDFAWYNGFIREEFERLVVTEEGHRAAEAKGTLDPAPLYRLWLRLYKGPIPNLLSLVQWVSRLGTEWVTVSSLREVLLPLIRPYYYDTPQDVLERRVLAMMVHLGLLRWGETEAREAVVRMTSQGRSIVKGTSLAFEDTIRMDGTGVDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQB7</accession>
    <name>A0A398CQB7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04725">
        <property type="protein sequence ID" value="RIE04725"/>
        <property type="gene ID" value="D3H35_04370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="91" mass="10315" checksum="1C1A59CBEDBEB5A9" modified="2018-12-05" version="1">MNIRILAATMKHDESNGYLGHVRFEAEGHKQPYELTLQSDKRIDDWNYALNFLDESGSEQQIEAVEKALEEDDDIFDSLVDAALASLDDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQE5</accession>
    <name>A0A398CQE5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04765">
        <property type="protein sequence ID" value="RIE04765"/>
        <property type="gene ID" value="D3H35_04615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009651">
        <property type="entry name" value="Met_g_lyase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46658">
        <property type="entry name" value="PTHR46658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06838">
        <property type="entry name" value="Met_gamma_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="434" mass="47367" checksum="0BDFC6DC2094448A" modified="2018-12-05" version="1">MRARLRQRRDGKVEVRVTDWERKWEQLAKEAETIAADRLRAMDSIVERNQWKVIQAFQKQKVSDYHFAGSTGYGYNDRGREVLDLVYADVFGAEAAIVRPHLVSGTHTISAALFGCLRPGDELLFVTGKPYDTLHKVIGSAGDGTGSLSDWGVSVKMVALLPDGRVDWDSVAAAVTDKTKMFGIQRSRGYDWRPSFTIAQLREMTARLKELKPEAIVFADNCYGEFTEELEPPHVGVDLIAGSLIKNPGGGLASSGGYIAGRADLVELAAYRITAPGIGGEVGAMLGTTRSIYQGLFLAPLLVGQAVKGSIFAACMFESLGFETHPRWNDPRTDLIQAIRFQSAEPLIAFVQAIQKAAAVDAHVVPEPWDMPGYEHPVIMAAGTFIQGGSLELSADAPIREPYIAYMQGGLTYAHVKYAVKLAISELGIRGYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQW2</accession>
    <name>A0A398CQW2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_04670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04902">
        <property type="protein sequence ID" value="RIE04902"/>
        <property type="gene ID" value="D3H35_04670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="72"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="288"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="761" mass="85296" checksum="65157938A0790699" modified="2018-12-05" version="1">MNRLTGKTESVEEWLQVLRGKPEIMENVTHWHTKPASPARTVPFPERIHPKLAEALRAKGIEKLYTHQAASFGAVAEGNHVVTVTPTASGKTLCYNLPVVQTLLEDDSARALYLFPTKALAQDQVAELQELANLMEADIKTHTYDGDTPPTVRQAIRNAGHIVVTNPDMLHSAILPHHTKWVKLFENIRYVIIDELHAYRGVFGSHVANVVRRLKRICQFYGSNPQFLCASATIRNPREHAERLVGETVALVDDNGAPTGEKHLVFYNPPVVNQQLGIRRSSVLESQKLAALLLRNGIQTIVFARSRVRVELLLTYLQEQVKHELGAKSIRGYRGGYLPKLRREIERGLRSGEIRGVVSTNALELGIDIGQLQACVLNGYPGSIASTWQQSGRAGRRHGSSVTFLVASSNPLDQYLIQHPDYFLGTPAEEARIHPDNLLILLDHVKCAAYELPFEEGDSFGEEKLTDLLEFLAEERVLHRVGSRWYWMEQAFPAHNISLRSAAQENFVIVDMTEGHKVIGEVDRFSAPTLIHEEAIYIHEGVQYQVEKLDYPEKKAFVREVNVDYYTDASQAVELKVLHSDLEARSGPLTRQYGEVMITAKPTIFKKIRLRTHENIGSGPIHLPEEELHTSGYWFSFSEEETAKRSANDMQMALLGVANVLIHLAPLHLMCDPFDIRVVPQVKALHTKRPTIYFYDRYPGGIGLSRRLYDLHDTLLEEAERLIHGCGCLSGCPACVGPIEEVGLLGKDLALGMIEGLRAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRC3</accession>
    <name>A0A398CRC3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LytR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_24215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01464">
        <property type="protein sequence ID" value="RIE01464"/>
        <property type="gene ID" value="D3H35_24215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="50"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="305" mass="33981" checksum="1570F7F3F64B221B" modified="2018-12-05" version="1">MADKVEKQLADSYHPLDNRPSDAEPPQAQATEPFSMLIMGVDARKNERGRSDTLIYTVVRPKDGNVLMISIPRDTYADIVGKDKKDKITHSYVYGGPEMAVATVEKLLDAKVEHYASINFQGFVEVVNTLGGISLPITKDLVNDDPGHEKFVVKANQSSYDGKDALNYVRYREDAGGDVSRTERNREFIESIIRKTASLKQWSKIPEVLGIVGDNFRTDLAPESMSDLTKQFLQVDHRIQSYTLKGVGKRMGPSNLWYFVADEDDLTDIRQTIAAWMNADTPVEQLKAPGQKKADSADKSAKVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRD8</accession>
    <name>A0A398CRD8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LytR_cpsA_psr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_09760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03829">
        <property type="protein sequence ID" value="RIE03829"/>
        <property type="gene ID" value="D3H35_09760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="84"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="309" mass="35217" checksum="00A89118AB16A845" modified="2018-12-05" version="1">MKRWIWISAGAAVVILLGIVGTGGYAYFSLKHTAKQVYVPLPDKPKYVSKDTELKRPETIDTSKLSPFTVLLLGVDERQGDRGRSDTILVLTVNPKQEKALLFNIPRDTRTEIAGRKSQDKINHAYAFEGVAGSLATVENFLDMPIDYYVEVNMEGFKSIVDTLNGVDVVNAFAFSYEGSEFPAGEQHLDGDQALKFSRMRYDDPRGDFGRNERQRQIVRDVLHRASQWNNLWELPDVLKTVGNHVRTNMTFDEIQDLATKYRTRIAKVESTEIRGKGSMINGIYYYLVDEKERDRIHSDMKKLLMEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRI7</accession>
    <name>A0A398CRI7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_24540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01524">
        <property type="protein sequence ID" value="RIE01524"/>
        <property type="gene ID" value="D3H35_24540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="124" mass="13773" checksum="9378058661CB9F1E" modified="2018-12-05" version="1">MENDQHKRLLEFLESSFDHEGTMCFLAVSASQVGQDGSKQEITLKVRVALAFREGESVTPYFDGTDLYVTICSNSIQFTNEDEWSEGPPIMEGSPIALAAGWVSELAPPFWISLEAREAANRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRJ4</accession>
    <name>A0A398CRJ4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-layer homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02041">
        <property type="protein sequence ID" value="RIE02041"/>
        <property type="gene ID" value="D3H35_14855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="87"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="149"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="216"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="277" mass="29320" checksum="74C8BBAF98A29C36" modified="2018-12-05" version="1">MVGNAYDFSVSLLLGNVERTVSEFDSYVERSISVNSSGLTASELTVVRLDAESGDATYVPTSTETASGKIKVKFSRKGNSVYAVMRKAPLVYSDMTKHWAKADVSKLAAKFIVSGINSTQYKPEQAITRAEFAEYIARGLGLTGDKSVVTSKYKDVPATGASAAFIGAASKAGIVSGGTDGKFRPNASITREEMASMLVRAMKYAGVSTTASSTALNKFTDRAKVGSWAKDGVAACVQAGIISGVTPTTIKPQNNAKRSEAASMITRFLKYVDLLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRL3</accession>
    <name>A0A398CRL3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03418">
        <property type="protein sequence ID" value="RIE03418"/>
        <property type="gene ID" value="D3H35_12185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="152" mass="17574" checksum="3D25B4A511238732" modified="2018-12-05" version="1">MMPIRNSAKAIIIHNESLLLTKNKDDQGYFYLFPGGGQEKGEELKHAVKRECMEEAGCEVEVEDLLFIREYIGKNHEFAEWDKEVHQVEFYFRCILENKDTPASIGENPDENQVGVEWVELSRLDEIRLYPNALGEKIKRGNYSPCYLGDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSH0</accession>
    <name>A0A398CSH0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidase_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02321">
        <property type="protein sequence ID" value="RIE02321"/>
        <property type="gene ID" value="D3H35_16515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024301">
        <property type="entry name" value="Amidase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12671">
        <property type="entry name" value="Amidase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase_6" evidence="1">
        <location>
            <begin position="43"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="208" mass="23658" checksum="4ED127D3C9999503" modified="2018-12-05" version="1">MGLPSAPYMNPDALYRFGSRVYSGVRSGAAGGWNGEARSGVPYRREAAVAFAERWWNEPSPSYEEFEVNCTNYVSQCLFAGGAPMNYTGKRDSGWWYKGKANGQEQWSYSWAVSNSLSHMLSVPRVNGMRADVVSSPSYLRLGDVICYDWDGTGRFQHSTIVTAFNPEGQPLVNANTVSSRHRFWDYRDSYAWTDRTQYRFFHIADEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSM0</accession>
    <name>A0A398CSM0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_16790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02371">
        <property type="protein sequence ID" value="RIE02371"/>
        <property type="gene ID" value="D3H35_16790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM_fam20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017354681" evidence="6">
        <location>
            <begin position="35"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="7">
        <location>
            <begin position="615"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="719" mass="77633" checksum="61266CDFBC452460" modified="2018-12-05" version="1">MFKSVRRTIVAAFLATALFAGLALPGAPVSTAFASPDTDVSNKQNFSTDVIYQIFTDRLYDGNSGNNPSGSSFDGTCTNLKLYCGGDWQGITDKINANYFSNMGITALWISQPVENIYSVVNYSGVNNTSYHGYWARDFKKTNPYYGTVTDFQNLVSAAHAKGIKIVIDFAPNHTSPAMETNSAFAENGKLYDNGTLLGGYTGDTNGYFHHNLGTDFSSLENGIYKNLYDLADINHNNSTIDTYFKDAIKVWLDLGIDGIRVDAVKHMPFGWQKNWLASIYSYQPVFTFGEWFLGVNDADPNNVQFANESGMSLLDFRFAQKVRQVFRDNTDTMYGLDSMISSTATDYAQVSDQVTFIDNHDMDRFKSGTVSDRRVEQALAFGLTSRGVPAIYYGTEQYMAGSGDPGNRARISSFSESTTAFNVIKALAPLRKSNPAIAYGTTQQRWISNDVYVYERKFGDSVAVVAINRNGSSSTSVSGLITSFASGTYTDALGGLLNGNSITVGSGGAVSTFTLAAGGVAVWQSTPTQTTPVVGHVGPVLGKPGNTVTIDGRGFGSTKGTVYFGTNAVTGANIVSWEDSQIKAIVPSVTPGKYAVKVRTSGSVDSNSYNSFNILTGTQVSVRFIVQNASTTYGQNVYLVGSASEIGGWDTSKAIGPMFNQIITAYPNWYYDVSVPANTALQFKFIKKNGATVTWEGGSNHTFTTPSSGTATVTVSWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSW6</accession>
    <name>A0A398CSW6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphate-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D3H35_20050</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the system for phosphate transport across the cytoplasmic membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex PstSACB involved in phosphate import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cell membrane</location>
            <topology evidence="2 11">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the PstS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02907">
        <property type="protein sequence ID" value="RIE02907"/>
        <property type="gene ID" value="D3H35_20050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011862">
        <property type="entry name" value="Phos-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02136">
        <property type="entry name" value="ptsS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7 11" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0732">Signal</keyword>
    <keyword evidence="6 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027151739" description="Phosphate-binding protein" evidence="11">
        <location>
            <begin position="29"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="13">
        <location>
            <begin position="47"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE02907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="313" mass="32539" checksum="F231A3EFBFAD3C72" modified="2018-12-05" version="1">MKKSLVLLLTLVLAFTLAACGKSNNSESSGSPSDPASESTDNGAGSDLSGTILAAGSTALQPLVDQVSKKFMDKNSGVTVTVQGGGSGGGLTQVQAGQADIGNSDIFAEEKFKDADADKAKELVDHQVAVVSIAAVANPKANVDGLTKQQLVDIFTGKITNWKDVGGADQAIVLVNRPASSGTRKTFEKYALGETSQDLPGSIQEDSSGTVRKLVAETPGAIGYLALSYLDDSVKALKYDGVEATADNVAAGTYPVWAYEHMYTKGEPNAAVKALIDFVLSDEIQNSDVTELGYIPIGKMQVTRDVTGAVTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSZ2</accession>
    <name>A0A398CSZ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03878">
        <property type="protein sequence ID" value="RIE03878"/>
        <property type="gene ID" value="D3H35_07870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="258" mass="28888" checksum="91AEE07B26D94199" modified="2018-12-05" version="1">MSSLISEKGNTQMLKKKAAGLTRKSSQSELSPDAPPSTPFEYGLDLAIRLHHQGIEGDANAVRKANIAFQRLRDGHPGHPIADAYHGSVMALMARDETNVMQKMQLAKRGLELLDQAVASEPRDRTIRMLRGKVAYRLPESFFRRTETAIEDYIILIDGEIRSPGGFDKETYSTLISELAEAYERINRHEEAALCWKNLNKLTENPAYRKLAQRKMKPEKSLPSSSKAVETKPPELRDWIGAAVLVAGASVVHWIGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTC3</accession>
    <name>A0A398CTC3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02561">
        <property type="protein sequence ID" value="RIE02561"/>
        <property type="gene ID" value="D3H35_17900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="126" mass="14541" checksum="04CD029C1068E7A1" modified="2018-12-05" version="1">MEILETKKVVEDINTFIGSQLWLDFEVLQYDKQKLTIIGSIDISNMHDIEIVFEDIFFVSLPIEWKTDTSRPVLSILEGEKAKILNKKFQVEQGHSIFAFAPEDYPDDFGCYVCAKKIAFNLTSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTD6</accession>
    <name>A0A398CTD6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF58 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_08730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04028">
        <property type="protein sequence ID" value="RIE04028"/>
        <property type="gene ID" value="D3H35_08730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="183"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="370" mass="42023" checksum="9304B29CD6CC9EE0" modified="2018-12-05" version="1">MPFYLVIVNGMILLFILTYIYRRQALKNVTYARRFSRMTVYEGDRIEMVEEIENRKLLPVPWLRLESYMSRELKFDKQANLDINSGEMFQNHLSLFSLRPYRRIVRRHELRIAKRGLYSLNSATMTAGEPLGIVETSKQFPLTLSLLVYPLAIPLQELPLPNHSWLGNIVVRRWIVEDPFLTAGVREYAPGDSLSNINWKATARMGSLQIHRKDHTADHRLVICLNIEINPAMWRTVTEPERIERGIRYAASVAGHALKNGIETGFICNGWLHGETKAPIRVEPQGGSVQGEVILAALAKLQLETSSNMAYLLDEEAGRLSTRTDYLIITCHRDEKLVAAANRLRALGNGIEWMDIPADATGGEAHEYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTH5</accession>
    <name>A0A398CTH5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-ketoacid dehydrogenase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04569">
        <property type="protein sequence ID" value="RIE04569"/>
        <property type="gene ID" value="D3H35_05630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="4"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="328" mass="35510" checksum="F7D6B36C049B9105" modified="2018-12-05" version="1">MPEIEYIDAIRLAMKEEMERDGDVFLLGEDVGLKGGVFGTTKGLQLQFGELRALDAPLAESAIAGVAIGAAMAGMKPIAEMQYSDFMFPAANQIISEAAKIRYRSNNDWSCPIVIRAPIGGGVFGGLYHSQCPESVFFGTPGLKIVAPATAYDAKGLLKAAIRDPDPVIFFENKKCYRSIVDEVPDDDYIVPIGKANVMREGTDITVIGYSMPLHFALQAAQELAEEEGVEAHILDLRTIQPLDREGILEAAAKTGKVLIIHEDNKTGGIGAEVAAIIAEELLYDLDAPIRRLCGPDVPAMPINPPGEKHFLLNKEKVKAAMLELARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU03</accession>
    <name>A0A398CU03_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02444">
        <property type="protein sequence ID" value="RIE02444"/>
        <property type="gene ID" value="D3H35_17215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="474" mass="49858" checksum="1C613B894D7CA16B" modified="2018-12-05" version="1">MGSALPVLPGVSIQVIREVVPTPMDSPGVLGILGCVGNYTPKQKLTIVGSVQEITDAYGSATLASIPELRQAFSAGLNQVVISPVDPSTALAAYSTIPVTADNAGTGLGVTAKVAGAWGNGISVQATPKIGAGTNSSTQLVDVTVYYPDENTLVEAYRNLSTSASDSNYFITAINAASGYIVLSPMTGSKVVVPNTANGMITLNKGKDASVQAFQDALDRLKDIEEVDMVAASLSPDPSNINNITQIYAQILSHCELMASQNYPRIGFGQTISALNDRADVDNAQLMIAPLISERFVFSAPAGYLGSVIGMVAGMNFYESPTYKTVPNVVSLNWDYTASELTTLVSSGVFAIDQLPHKGIVCVKGITTDCGQLNVTRIADLCVRQINHIASGFIGLLNTDVQRLALKQLIIQTFTDMENQSALVKSADGKLPAFVVDVTSTPADFSQGIVRITAAVRPVRAIDYIIATLTVQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU28</accession>
    <name>A0A398CU28_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell division protein FtsJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04779">
        <property type="protein sequence ID" value="RIE04779"/>
        <property type="gene ID" value="D3H35_04695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="115" mass="12650" checksum="1BD201C650230D04" modified="2018-12-05" version="1">MINVFLDDVRPIPRGFAAARSAEECILLLRHSDVAVLSLDFELGYDQPNGLAVVHAIIVSGRYPREVYVHSSSLMGRAEMVRALRESAPLDVVIHDGPMPEQVKEAIAEGKIRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU81</accession>
    <name>A0A398CU81_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative cysteine ligase BshC</fullName>
            <ecNumber evidence="1">6.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">bshC</name>
        <name evidence="2" type="ORF">D3H35_06425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the BshC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04248">
        <property type="protein sequence ID" value="RIE04248"/>
        <property type="gene ID" value="D3H35_06425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01867">
        <property type="entry name" value="BshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011199">
        <property type="entry name" value="Bacillithiol_biosynth_BshC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10079">
        <property type="entry name" value="BshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012535">
        <property type="entry name" value="UCP012535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03998">
        <property type="entry name" value="thiol_BshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="574" mass="64787" checksum="B278F6B015377F73" modified="2018-12-05" version="1">MATKFLTSFAPLCTINHDILQLWKRGNVPVIVNTLQGPVSPTLSERYREQDEAVVALFGKHPLQKEDWHARADELDRRSSSSQADRTALAEALRSFQSGMNEHPAVSRSLERLAEPGSLVVVGGQQAGLFGGALLIFYKAMTVVQTARHAEKLLGRPVVPVFWIAGEDHDFDEANHVNVQTQAGELRRVRLERPDGSRLAVSRTRLSPEAWEAALQELETELPDSEFKPALIDRLRSHVTDAPTLSLAFARLLSEWFGPEGMLLLDADDAGLRALEGPMFRELIERNDKLEEALKAGEKKVASLGFSLQAETAFGSANLFLHHDSGRLLLHKEPNGNFADRRRSVSLCRDDMLSLTEDSPERLSTNALTRPLMQDYVLPVLAAVLGPAELAYWGILGPAFAEFGLEMPLLVPRQSFVYVETGIARQLDKFALTPEEALWNWERRKEQWLASQDEWRLEEKFRNAKEQFLAIYRPVMETVAALQPGLAKLSESNRDKIVEQISFLENRSMDALAKQHEASLRQWDRIRTALMPGSKPQERVFGTIHFWNRYGPEWLTRWAEVPYEPNGGFRLIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUF1</accession>
    <name>A0A398CUF1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_18200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02614">
        <property type="protein sequence ID" value="RIE02614"/>
        <property type="gene ID" value="D3H35_18200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="6"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="106" mass="11903" checksum="8E83CC6A68595EFC" modified="2018-12-05" version="1">MRTNKLTLRTDNREDRTIVHVGGELDLEVASQMRAAMEPLMGLADRRLTLNLSELKYIDSTGIGILISVLKARHSRQAPFDVEDVPEHIRKLFDMTGITPFLAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUK8</accession>
    <name>A0A398CUK8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02971">
        <property type="protein sequence ID" value="RIE02971"/>
        <property type="gene ID" value="D3H35_20425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05324">
        <property type="entry name" value="carb_red_PTCR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045313">
        <property type="entry name" value="CBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="236" mass="25029" checksum="93B3696A3E60F0C6" modified="2018-12-05" version="1">MNNKIALITGANRGLGLEIGRQLGRQGIIVLLGARSLSKAEDAAVQLKAENIEAYPVELDVTDDRHIRAVAAKIKAEYGKLDILVNNAGIFLDHEGNNTDVMRRTFEVNIFGAHALTEALLPLLNASPEGRIVNQSSILGSVATILTNEMYAKAAAPAYTASKAALNAWTAQLSIQLRGTNVKVNACHPGWVKTDLGGKDADMEIHEGAETAVSLATLPSDGPTGGLFHGSETLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUS5</accession>
    <name>A0A398CUS5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_19110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02754">
        <property type="protein sequence ID" value="RIE02754"/>
        <property type="gene ID" value="D3H35_19110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="3"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="403" mass="42810" checksum="FD3619F63F8812A4" modified="2018-12-05" version="1">MKTAVWLYLFLFVAFFDLHAQYPMLTPFAVSLGAAPSFIGLVMGMYSLTHLPGNMLAGYGVDRYGSRWFIAASLTGAGILLILQSRVTDPWHLLYIRSASGFVLAFLSPACMALLAKLARDHIHQGKLMAGNGLVHTVASVVSPAAGAWLAATIGFGASFAILGWGLLFTGITSILFIKEPVKIRQTSSLEQGGVDSDQGASDLRKTTSAANKTAASGGRFPWAVFAIPISLACAQGILSFELPLRARTSAEVLAVGLMFSVVSLGALATLVLLFLNKYLPYIRTVAGLSLLAVAYYGLASGWPLPLSMMLFVIGMAKGIIFPAMTSFLIQLSGEARYGRTFSFLSISLSIGSFLGPVLAGAARDSFSPFFISFLALMLAMAVIFPRPAFRAGWNGDPTAPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUT3</accession>
    <name>A0A398CUT3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper amine oxidase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02764">
        <property type="protein sequence ID" value="RIE02764"/>
        <property type="gene ID" value="D3H35_19170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="1">
        <location>
            <begin position="424"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="526" mass="58377" checksum="289B696DE4A00316" modified="2018-12-05" version="1">MRKRNYRKIGLWLSAALVLLLVGCQAIGGLNLDDMILKQLEVKSAEQSGKVEIELELNDKVVLAEAAEDPAAAKALELFKKMTFTVEHAAIDSKNRFQLKGAVNFGGKGDIPITLGMDEKAIRFDIAGAPEPIVLEIDSFSAQSLQGVLSDAGLPDIQSDDADLTEWSRSLLRTVGTYFVHHLPNPPKITVDRLAAPVNGTTTTLTKVHAELNGEELGDLIPAYLDNIVKDETGFKEMLRQFLKALYSLPPELVEQLGLEEPPTEAETEEAINAGVEELFPMLKEFQTNLADFRKEKEWGQIFDKGISLVTDLYVDDSLHVRKSNVDLTIAPAYFAEEDSPIRSIRIRSSFDIWNVNGDVTVPAVEVPSNALTEQELDAMQPYEYVRGLDEQSVLYDLLKNDLAIDDQSFEISDEWGIPWMADEQDNVYVPVRYSLEQFGNEPIVYTKKTKEIRFTDGATSQEIVLHIGSAAATVNGKPVTLKHAVFQDGPYAYISADDLFGLLHAEYSIAESDYGDFVLSVTRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV68</accession>
    <name>A0A398CV68_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_20135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02924">
        <property type="protein sequence ID" value="RIE02924"/>
        <property type="gene ID" value="D3H35_20135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="66"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="280" mass="31671" checksum="653BB419A5ED7C1B" modified="2018-12-05" version="1">MEKSIKKYFAFFVLPTLLTFLALFLVPFLLGVYLSFTDFTTVNDSKWVGFSNYSRVFEDTDFLKASWFTVKYAFVSVISVNLIAFIFAMVLTKGKKGTNLFRTVFFMPNLIGGIVLGYIWQLIFNGILFKYDLTLTFSAKYGFWGLVILTSWQLIGYMMIIYIAGIQGISKDLLEVATIEGASRFQTLRKVTIPLIMPAITICLFLTLSNAFKLFDQNLALTAGAPSKESTMLALDIYNTFYGRTGFEGVAQSKAVVFFVLVALISLVQLVITRRREIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV86</accession>
    <name>A0A398CV86_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_01930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05199">
        <property type="protein sequence ID" value="RIE05199"/>
        <property type="gene ID" value="D3H35_01930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="142"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="323" mass="35397" checksum="15BE049FE6AC42AA" modified="2018-12-05" version="1">MGTIHADRYMSMPEAELVAVCDINEQAAASLGRTTGAPHFTSFQEMLEQAKPDAVSIAVPTYLHVPLVKQAAENGVHVICEKPIALTSEEAAKALRICEEYGVRLFVGHVVRFFPQYVQLAEKVELFGGDRGGVYHAKRAGSHPALVQPWFKETDKSGGVILDLMIHDIDYILGTFGEAVEVYAFNRVTDDLDYAAATFRFRNGTIAQLEAFWGYPGPFHTAFEYASAGGIVRADSSDAESLRVRSAAPAGSGSAFVETPQSVMLQDPYYRELRHFLECLRSGEKPIVTAQDALLAIRWAEAALKSVRSGLPEKPSEEEDGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVT9</accession>
    <name>A0A398CVT9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsO</name>
        <name evidence="8" type="ORF">D3H35_11630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="3 6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03331">
        <property type="protein sequence ID" value="RIE03331"/>
        <property type="gene ID" value="D3H35_11630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="89" mass="10384" checksum="FB54C46042AF32D3" modified="2018-12-05" version="1">MALTQERKQELIETHKTHASDTGSPEVQVAILTENINNLTTHFKSHKKDHHSRRGLLKMVGQRRKLLAYLKNKDVRRYSALIEKLGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWP6</accession>
    <name>A0A398CWP6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7 8">Elongation factor Tu</fullName>
            <shortName evidence="7">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">tuf</name>
        <name evidence="10" type="ORF">D3H35_02230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE04988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04988">
        <property type="protein sequence ID" value="RIE04988"/>
        <property type="gene ID" value="D3H35_02230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="396" mass="43422" checksum="08DE3B3A9AD2E057" modified="2018-12-05" version="1">MAKAKFERNKPHVNIGTIGHVDHGKTTLTAAITTVLSKKYGGAAVAFDQIDKAPEERERGITISTAHVEYETPNRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLSKQVGVPYIVVFLNKCDMVEDEELLELVEMEVRDLLNEYEFPGDDTPIIRGAAREALQNPDGPWADKIIELFEQVDTYIPQPERDVAKPFLMPVEDVFTITGRGTVATGRVERGTIKIGDEIEIIGLVEESRKSVVTGVEMFRKLLDSAQAGDNIGALLRGVDRKDIERGQVLAKPGSVKPHTEFTAQIYVLTQSEGGRHKPFFTGYRPQFYFRTTDVTGIIDLPEGTEMVMPGDNITVTVKLIAPIAVEEGTRFSIREGGRTVGAGAVASIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWR8</accession>
    <name>A0A398CWR8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpmD</name>
        <name evidence="8" type="ORF">D3H35_02330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05008">
        <property type="protein sequence ID" value="RIE05008"/>
        <property type="gene ID" value="D3H35_02330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_L30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="PTHR15892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="7">
        <location>
            <begin position="5"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE05008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="59" mass="6505" checksum="CF21030CA6B47A4D" modified="2018-12-05" version="1">MAKLQITLVRSLIGRPGVQRQTVQSLGLSKLNQTVVKEDNAAIRGMVNHVSHLIEVKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWX2</accession>
    <name>A0A398CWX2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03701">
        <property type="protein sequence ID" value="RIE03701"/>
        <property type="gene ID" value="D3H35_10410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008391">
        <property type="entry name" value="AXE1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039069">
        <property type="entry name" value="CE7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40111">
        <property type="entry name" value="PTHR40111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05448">
        <property type="entry name" value="AXE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AXE1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="321" mass="35739" checksum="B0FDC295961DAFA0" modified="2018-12-05" version="1">MSNAIARRIEELEKMSPPLTAMPDLEDYWTRTLKHFETKPLHGSRTRVDTPMKFAEVFRVEFEGFDDTRISGWYMLPRFQEDVGSDRKRPCVVLFHGYMGGKGMPEDYGSYLLMGMAVLAVDVRGQGGETGNRLPQEYGMTKGWITQGILDRDTCYYKAITIDALKAIEFAARQDEIDPSRIAIHGISQGGGLVLLAAALSDIPAVAIAHIPNMCQMDYGILNSNSSLSEAAEFAAKRPELLGKVLETLSYFDNLNMACRIRVPVLVTCGLKDTITMPETIFAAYNRIAAPKRIEVSPFTGHAVTGHLNRLAMEFLNNHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWZ1</accession>
    <name>A0A398CWZ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sulfate ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_10530</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03721">
        <property type="protein sequence ID" value="RIE03721"/>
        <property type="gene ID" value="D3H35_10530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005667">
        <property type="entry name" value="Sulph_transpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406">
        <property type="entry name" value="PTHR30406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00969">
        <property type="entry name" value="3a0106s02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="49"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE03721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="264" mass="28648" checksum="7472901C0BD7B9A8" modified="2018-12-05" version="1">MRKLWIGLTVVVFGLLLVAPLVRIAMGAWDEGWSGFARGVTRPEALHALYMTLLIVVIVTIINALFGVMLSLYLVRATWLGRKLKQVLNSVVDLPFAVSPVIGGLMIVLMLGPETAIGAMLGKAGIDIVYALPGMIIATLFVTFPLIIREVMPVLQEIGHQQEEAASTLGAYGWTTFWRVTWPSIQWSVVYGIVLTVARSLGEFGAVLVVSGNILFKTQTATTLVYQDVENFSLTSANAVALVLAAGSIALLLFMEWAKARKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWZ7</accession>
    <name>A0A398CWZ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Crp/Fnr family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_07110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04357">
        <property type="protein sequence ID" value="RIE04357"/>
        <property type="gene ID" value="D3H35_07110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="33"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="4">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="223" mass="24830" checksum="AA05B84B860197BD" modified="2018-12-05" version="1">MISESLTSRVLDSFPCLSAVTAEEWNEAQPTVRTFPAKSCIFQRKDASSYGMFLLSGTARISRIAEDGGESVISILKAGEVCALLVLSGLSDRDYPGALTAESEVEALFVAKQSFLNWLQTHAEIRSVVFGGLLDNLLSISVQYDGRRLEPLDGRLAKALLRTTSEQKQLLNMTHHELAVEIGSAREVVSRALRRYRQRGWIETGRGWIRIVRREELESMLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZN0</accession>
    <name>A0A398CZN0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Diaminopimelate epimerase</fullName>
            <shortName evidence="8">DAP epimerase</shortName>
            <ecNumber evidence="4 8">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dapF</name>
        <name evidence="10" type="ORF">D3H35_07290</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="4 8"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04384">
        <property type="protein sequence ID" value="RIE04384"/>
        <property type="gene ID" value="D3H35_07290"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018510">
        <property type="entry name" value="DAP_epimerase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01326">
        <property type="entry name" value="DAP_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="212"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="222"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="276" mass="29759" checksum="FBFEE62042348D35" modified="2018-12-05" version="1">MEFTKMHGLGNDFIVVYGESELPADAAELAVRLCNRFFGIGADGLVYILPTDRADFKMRIINSDGSEAEQCGNAIRCVAKYVYDNKLTDKTELTIETIGAGVQPLTLETQDGKAVRVTVDMGAPILNGLDVPTTIDANPVIGQSVTVDGREFRFTAVSMGNPHCVIYVDDAVGFDLAAWGPKLETHPLFPRKINVEFAKVNSRDQVDMRVWERGAGPTLACGTGACATLVSSVLNGLTDRKATISLAGGDLFIEWSEENNRVYMTGPAAIVYTGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZP1</accession>
    <name>A0A398CZP1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Menaquinol-cytochrome C reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D3H35_04055</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04671">
        <property type="protein sequence ID" value="RIE04671"/>
        <property type="gene ID" value="D3H35_04055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005798">
        <property type="entry name" value="Cyt_b/b6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036150">
        <property type="entry name" value="Cyt_b/b6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008168">
        <property type="entry name" value="Cyt_C_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00032">
        <property type="entry name" value="Cytochrom_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00605">
        <property type="entry name" value="CYTCHROMECIC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81648">
        <property type="entry name" value="SSF81648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51003">
        <property type="entry name" value="CYTB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_CTER" evidence="12">
        <location>
            <begin position="32"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="13">
        <location>
            <begin position="205"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE04671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="288" mass="31856" checksum="F415183E7EF51833" modified="2018-12-05" version="1">MAHKQDPNEKIVYVGDSRIRKRDNKNVVPPDYTAFPGKSEAFIPNFLLKEWMVGVVALVGVLVLVISEPAPLGYPANPLNGAFIPMPDWYFLFMYQLLKYPYTSEDFIVFGTALFPALLFGGLLLAPFLDTGKERRFYRRPMASSFMALSLVAVIYLTWVSWDHYQFELKASGTIPEHIEREIKAEEAIEKGLPRPIPGKEKIPAMVAADDVAFTGTMKEAQCIACHGAELEGGGAPALRGIGDTLSKEELVATITNGKGDGMPPFKGKLTDEQIDQVATWLSKQKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZX9</accession>
    <name>A0A398CZX9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000006">
        <property type="protein sequence ID" value="RIE05417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05417">
        <property type="protein sequence ID" value="RIE05417"/>
        <property type="gene ID" value="D3H35_00580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="73" mass="8251" checksum="CE928E701336941B" modified="2018-12-05" version="1">MAVRLSNSNAPERVEKERESFRADNHWGLFDENGRLLTNLSILPLEVWIHGVRMKMGGVASVSSWRTRAGKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CB56</accession>
    <name>A0A398CB56_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_28570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00376">
        <property type="protein sequence ID" value="RIE00376"/>
        <property type="gene ID" value="D3H35_28570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="154" mass="17436" checksum="1DD2E108B99D74AF" modified="2018-12-05" version="1">MVGLDFMMQDWLNDPKYALFTIIMTDIWRVAGFSMVVYLAGLQFIPKDLIESSNIDGANYWSRFKHIVFPLLAPAFTVNVLLAMIGSMKVFEIVMVLTEGGPGYTTEVFYTLIRTTFSSGEMGYATAVNMLLFFFVTLVGVPVLLKMKKREVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD65</accession>
    <name>A0A398CD65_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00355">
        <property type="protein sequence ID" value="RIE00355"/>
        <property type="gene ID" value="D3H35_28445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="272" mass="29842" checksum="E1A3336AE9FB11EB" modified="2018-12-05" version="1">MSQKVALITGASSGIGKEAAIELKNKGFTVYAAARRVDKMQDLAERGIHPIALDVTDDESMVHCVNKILKKEHRIDVLVNNAGYGSYGAVEDIPLDEARRQMEVNVFGLARMIQLVVPSMRKNQFGKIVNVSSMGGKIWTKFGGWYHATKFAVEGLSDCLRLELEPFGIDVIVVEPGGIKTDWGIIAAENLKKVSAKGPYAQAAGKAADGMIKNYTGNQLSKPELIARTIAKAATVKRPKTRYLVGFMAKPMVFMKNVFGDRAYDKIIKMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDA2</accession>
    <name>A0A398CDA2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_27360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00680">
        <property type="protein sequence ID" value="RIE00680"/>
        <property type="gene ID" value="D3H35_27360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="411"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="510" mass="58175" checksum="771E4FB7BC23B49E" modified="2018-12-05" version="1">MYKVFLVDDEPFISEGLCDAIDWSSYGLEITGRAENGLQALERLKEVPADILITDISMPVMNGLELIRAVRETRPDMKIIILSGYNDFHYLKEGMARGIENYLLKPINIEELTETLRNTVERLNTAVEPAFGYTEDEIGLLKDNILYRWMTGTIAPAELEERTRFLNIRLEGAYVQAALLRTDKEQCESANRAIKRFVRRMSDAVAFADMSNDLVVAVMAESSEACKRKAIELLTSLRQELPEIAFSRISLGTSERMDGGEQLSYERARRAQEYFLLLDRSEIAEYETLLLKPEEESAQLQVDWAEFGKLILAKDAEGLCARIDEEFDRAQTRERTTPELLRGLAIEMTIRLKMELDAIKPSESSAGGVFKAVFGKVAGATDREKLVAAVKETAVMITDALTRDDKSPVVKQILNHIHECYQEDMSLKSLGFQYKIHPGYLGKLFHKETNDTFTEYINKFRIEKAKELLKETPLKVHEIAKQVGYWETGYFHKQFKKYVGISPNDYRGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDE8</accession>
    <name>A0A398CDE8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_28985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00445">
        <property type="protein sequence ID" value="RIE00445"/>
        <property type="gene ID" value="D3H35_28985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="46"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="475"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="578" mass="66194" checksum="338A3AB462A5A185" modified="2018-12-05" version="1">MREDVFGCCTGNGRQSNFITKKPIMARSCGSAFRLKRESEVKAMFQALIVDDEVHAVRGLQAGVQWERLDIGVVHTAHSLRQAQEVFQAQPVHLMVCDIEMPQGSGLELTAWVKENYPDTETIFLTCHSDFSFAKQAIQLNSFDYLLKPVDYSELESVIGRALGKMRKERERRSFEETHHHYRKLWESHRPVVADRFWQDLIQQKIPANPLSIAEHSRNAGLTHPENARFMPVYARIQRWHKDLSERDRRIMEYALRNVLEEMMEPTPGAAVIPVGNGSLLTVVPIDEPNDDALTRDNCDAFIRNCNRYLFCDISCYVGVPVPLHEMVAMLRALENLDENNVTQINRTFILGETKKGESRMQPAPLSEWAEWMKQGARSKLAANVSHYLESWKAFDSRVDAQAMNSFYQDFLQMIFFVLQSKGLQANQVFAHNLLTDKPESALRSLSSLQEWVVYVLDVAMNHIHSLEENLSVVDKVKRFVAERIGEQDLSREDIASHVYLNPDYLTRIFKKDTGMSLSDYLQSSRIDYAKELLANTGQSVSEIAVASGYSNLSYFSTIFKKATGYNPVDFRKQHQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEA5</accession>
    <name>A0A398CEA5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase H</fullName>
            <ecNumber evidence="1">2.1.1.177</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA (pseudouridine1915-N3)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m3Psi1915 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (pseudouridine-N3-)-methyltransferase RlmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">rlmH</name>
        <name evidence="2" type="ORF">D3H35_24440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10221"/>
            <dbReference type="Rhea" id="RHEA-COMP:10222"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74486"/>
            <dbReference type="EC" id="2.1.1.177"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA methyltransferase RlmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.177" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01506">
        <property type="protein sequence ID" value="RIE01506"/>
        <property type="gene ID" value="D3H35_24440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070038">
        <property type="term" value="F:rRNA (pseudouridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18081">
        <property type="entry name" value="RlmH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00658">
        <property type="entry name" value="23SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003742">
        <property type="entry name" value="RlmH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33603">
        <property type="entry name" value="PTHR33603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02590">
        <property type="entry name" value="SPOUT_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004505">
        <property type="entry name" value="MT_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00246">
        <property type="entry name" value="tRNA_RlmH_YbeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="1">
        <location>
            <begin position="127"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="159" mass="17711" checksum="5EA3B31C0781CB6A" modified="2018-12-05" version="1">MQIQLVCVGKLKEKYWVGAVEEYAKRLGAYARLDIRELPDEKTPDSMSPAEEDQVRSREGERILAALKPDAHVVALAIEGDTWTSEQLAAHLDKQAVYGGGSVSFIIGGSLGLSPAVLARADKKLSFGRMTYPHQLMRVLLLEQVYRGFKINRGEPYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFF5</accession>
    <name>A0A398CFF5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YjzC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01453">
        <property type="protein sequence ID" value="RIE01453"/>
        <property type="gene ID" value="D3H35_24150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025549">
        <property type="entry name" value="YjzC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14168">
        <property type="entry name" value="YjzC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="60" mass="6969" checksum="F89B58932B17D369" modified="2018-12-05" version="1">MGEQSEFNPGDRVPNDGEYAEIGEAAFHTNVNNPKHVRLRAGERFPETSNHNRKWKRFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFI7</accession>
    <name>A0A398CFI7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-grasp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_22560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01185">
        <property type="protein sequence ID" value="RIE01185"/>
        <property type="gene ID" value="D3H35_22560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004218">
        <property type="entry name" value="GSHS_ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02955">
        <property type="entry name" value="GSH-S_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="70"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="331" mass="36779" checksum="273B392366F2F7E1" modified="2018-12-05" version="1">MNPYQVQNAQNKQIMKKAREMGIECEPLIPGCEDFLELSYRGKTIVINKTRSHKMPLMAGLLAKNKDASNLLLRRRGLPVPDYIVVSQAGEEAVRFLNTHRMVIVKPLDTSRSVGVTLRIDREDDLENAVKTARLHSEQVMIQQYVEGTDFRVLVIGGKAIGALEYKPAFIEGDGRSTIEQLIRKLNEDQLRRNSVGDAGSFQPVDVESKSLLMHLQELGKSLQAVLEQGERVELFSGGNILADGISEIVLDRSEDISAVNANIAVEAAKALQVDVAGIDIRCRDIRLPLNDENGGILEVNALPDMIDPSLFFQGASTDVFQSYLQYLFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFQ2</accession>
    <name>A0A398CFQ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage III sporulation protein AG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spoIIIAG</name>
        <name evidence="2" type="ORF">D3H35_26415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00732">
        <property type="protein sequence ID" value="RIE00732"/>
        <property type="gene ID" value="D3H35_26415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014195">
        <property type="entry name" value="Spore_III_AG"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02830">
        <property type="entry name" value="spore_III_AG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="218" mass="23743" checksum="8FFC72BA365FCA6B" modified="2018-12-05" version="1">MAKWLQKLETFIGGGPGGARRVRAFRWLVLIGLIGAALLLAASLLNVKTVDPSKQPDYSPYRDEDVPKQQEAFIGGGESGKDDPFTDIEAQLETRLKEMLETMVGVGSSDVMVTVESTEETVVQLNEKTTSQITEETDRNGAKRHITDVTRDGQVVLYEVSSGSKSPIIVKKLKPKVRGVIIVAKGAENATVHRLIAEAVSRGLDVPIHRISVVPRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFT9</accession>
    <name>A0A398CFT9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagellar protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02056">
        <property type="protein sequence ID" value="RIE02056"/>
        <property type="gene ID" value="D3H35_14930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="135" mass="15304" checksum="572EF6E0277148D5" modified="2018-12-05" version="1">MPRCGKLFARHFRDVCPDCLKRLEKEYEACVDYLRDHKGATINELSEETEVTIKQITRFIREGRISLVGAPNLSYPCEVCGILIRDGTMCDSCRGRLNRDVKNATSNDNPKASSAAQDYRSGGAYRIGDRLRDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFZ7</accession>
    <name>A0A398CFZ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation protein YabP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yabP</name>
        <name evidence="1" type="ORF">D3H35_23630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01365">
        <property type="protein sequence ID" value="RIE01365"/>
        <property type="gene ID" value="D3H35_23630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012504">
        <property type="entry name" value="Spore_YabP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022476">
        <property type="entry name" value="Spore_YabP/YqfC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038705">
        <property type="entry name" value="YabP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07873">
        <property type="entry name" value="YabP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011576">
        <property type="entry name" value="YabP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02892">
        <property type="entry name" value="spore_yabP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="93" mass="10357" checksum="4951A4E7AFD1CE19" modified="2018-12-05" version="1">MDHGKTAKHQEVRMLNRKLLEISGVGNVESFDNEEFLLETECGFLTVRGQNLHMKNLNLEQGLVAIEGLIHSLQYLDGNGAGKSKGLFGKLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG05</accession>
    <name>A0A398CG05_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D3H35_23990</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the beta sliding clamp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01430">
        <property type="protein sequence ID" value="RIE01430"/>
        <property type="gene ID" value="D3H35_23990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7 11 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="12">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="13">
        <location>
            <begin position="137"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="14">
        <location>
            <begin position="254"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE01430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="379" mass="42068" checksum="8E7F3194980F6720" modified="2018-12-05" version="1">MKLTILRNELNDAIQHVSKAVSSRTTIPILSGIKLEASFTGVTLTASDTDIAIQSFIPLETPDKTIGTVERMGSVVLPAKFFVEIVKKLPHEEVHIDVGERFQTLITSGSAEIQLVGLDPEEFPVLPTIQEDQVFSIPGDILRDMIRQTVFAVTTNEASPILTGVLWNLQDGVFKLVATDRHRLASRTSPVDTQEVRFSNVVISGKTLSELAKIVPDQNVLVDIVVADNQVLFKLGNVLFFSRMLDGTYPDTSKIIPQNFKTELVLNTKLLSDSIDRAYLLSREEKTNIVRLATTENGGIEISSSSSELGRVNEQLDVKEFHGEQIRIAFNSKYMLDVLKIIDSEQLFIGFTGAMSPIIIKPRDHDNGLHLILPYRTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG25</accession>
    <name>A0A398CG25_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease M5</fullName>
            <ecNumber evidence="9">3.1.26.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">RNase M5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ribosomal RNA terminal maturase M5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">rnmV</name>
        <name evidence="11" type="ORF">D3H35_23845</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Endonucleolytic cleavage of RNA, removing 21 and 42 nucleotides, respectively, from the 5'- and 3'-termini of a 5S-rRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ribonuclease M5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.8" evidence="9"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01405">
        <property type="protein sequence ID" value="RIE01405"/>
        <property type="gene ID" value="D3H35_23845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043822">
        <property type="term" value="F:ribonuclease M5 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01027">
        <property type="entry name" value="TOPRIM_RNase_M5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01469">
        <property type="entry name" value="RNase_M5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004466">
        <property type="entry name" value="RNase_M5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025156">
        <property type="entry name" value="RNase_M5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034141">
        <property type="entry name" value="TOPRIM_RNase_M5-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13331">
        <property type="entry name" value="DUF4093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00334">
        <property type="entry name" value="5S_RNA_mat_M5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 9" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Toprim" evidence="10">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE01405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="187" mass="20774" checksum="0E5578BB6A5667A4" modified="2018-12-05" version="1">MIREMIVVEGKEDTAAIRRAVGADTIETGGSAVGEDVLRRVELAFERRGVIVFTDPDSPGERIRKIVAERVPGVKHAFLTRDEARGKDGIGVEHASDEAIRRALDRVREPEAQGASVSTREPELEWSDLLDAGLIVHASSARRRERIGELLGIGYANGKTLYKRIVMFRITREEFVAALEQLEREGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG76</accession>
    <name>A0A398CG76_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_25670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00952">
        <property type="protein sequence ID" value="RIE00952"/>
        <property type="gene ID" value="D3H35_25670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="4"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="319"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="534"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="586"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="351"/>
            <end position="358"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="647" mass="71263" checksum="A7E2D209708F086E" modified="2018-12-05" version="1">MHLLSVQHISKSYGDKILFDDVTFGIEEGEKIGVIGVNGTGKSTLLKVVAGIDQPDSGSIAVGRSVRIRMLAQDPAFAPGETALEHVLGGDSPQLDAVREHAAAAAALELKPADEALQQRLIAAGLRMDELDAWGMESEARTALGKLGIADFDSPVGTFSGGQRKRVAMAAALLQPSDLLILDEPTNHIDNESVAWLESMLQKRRGALLMITHDRYFLDRVSNRVLELDQGRAYFYEANYSRFLELKLEREEREASSEAKRKNLLRNELAWIRRGAQARSTKQKARIDRYEALKEQGPKASAGKLDVSVASSRLGKKILEIDGLTKRLGGKTLIRNFSYIAVPEDRIGIVGRNGSGKSTLLNLIAGRLNPDEGSVEPGPTVKLGWFSQEHEEMDESLRVIEYIREGADQVKTADGTTVSAGQMLERFLFPPSVQWSVISKLSGGEKRRLQLLRVLMSAPNVLLLDEPTNDLDISTLAVLEDYLDEFPGVVITVSHDRYFLDRTAERILAFEGDGVIVQYVGNYTEYREFADRRDRTGATTSDGGSSTKLSSAAPASKPEGGGNGKDRPTKMSYKDQKDFEQIDGWIADAEERLKAVAGNMEAASSDSMRLQELMAEQSKLEEQLESLLERWTELNELAEQIAANKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG79</accession>
    <name>A0A398CG79_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminoacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_24225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01465">
        <property type="protein sequence ID" value="RIE01465"/>
        <property type="gene ID" value="D3H35_24225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017273153" evidence="2">
        <location>
            <begin position="33"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydro_3" evidence="3">
        <location>
            <begin position="419"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="670" mass="73356" checksum="6B87B9CF61D1BCED" modified="2018-12-05" version="1">MSINSRNSRKRKRRSPVLLVFLAFIVVVGFWAAKTLFSDKDASPGQGVGESGPPSAASSPSGQGSSPASPSASGKDGDAGSPDGQAALDKPTAAELAATYDIVIRNGRVINPETKLDKEGLNVAIQGGKIALVTEEELQGKRIIDATGLVVSPGFIDNLSYDPNPLGVWNKIADGVTTNIAMHGGTSTPEKWYPYYIRNNTPVNFGASFFYTQARNQFKISRYDTLKPEQIQKMVDQAEKALNNGVLGLSFSLEYVPGVNDKEIMPFMRLAYKYNVPVYFHARYSDMEEPGTNIDALNELIGYARASDAAVHIDHINSTGGTFSMTQSLGMVSEARAEGLDITSCIYPYDYWGTYLNSARFDTGWQNRFRITYKDLQIAGTNERLTEESFKKYQKEGKLAVAYAIPKEDVIDSLKAEYVMLGSDAILEPGFNNHPRASGTFARTVGLYVREQQVITLSDAIAKMSLMPAQRLEKQAPALKKKGRIAKGMDADIVVFDYDTISDQSTVEKPNLYSKGISYVLVNGQVALDEKGLHKDIHQGQPIKSEFLRVKAENAAESLAWDGSSAPLLEYRGERYVDLETLKSHGYVYEWNKVNKTFALTKGDSGADSAAIPKPKVGELMLERGYKLSWEGGRTELLSVGDRSYVPLSALSSLGWKATKSANGYSVDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGB2</accession>
    <name>A0A398CGB2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1540 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01495">
        <property type="protein sequence ID" value="RIE01495"/>
        <property type="gene ID" value="D3H35_24385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011437">
        <property type="entry name" value="DUF1540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07561">
        <property type="entry name" value="DUF1540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1540" evidence="1">
        <location>
            <begin position="5"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="51" mass="5580" checksum="4862C29C7A93B246" modified="2018-12-05" version="1">MAKDVLCEVNSCKHWAPGNNCAASSIYVVSNRGKQASNSEETDCKTFEPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGR3</accession>
    <name>A0A398CGR3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01933">
        <property type="protein sequence ID" value="RIE01933"/>
        <property type="gene ID" value="D3H35_14255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="125" mass="13009" checksum="F5A0E37071058F7C" modified="2018-12-05" version="1">MRGNKAPTVTIFDGRAGMRGNKAPSVTISGGRVGMRGNKTPTVTIFGSRADMRGNKAPTVTIFGGRVDMRGNKAPTVTIFGGRAGMRGNKAPTVTIFGDRAGMRGNKVPTVTIFDGQAVGRLSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGW1</accession>
    <name>A0A398CGW1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_24810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01695">
        <property type="protein sequence ID" value="RIE01695"/>
        <property type="gene ID" value="D3H35_24810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="77"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="298" mass="33426" checksum="F237E752A3449136" modified="2018-12-05" version="1">MEMKIKKKNSSYTGKDNQLAVMLLSPVFLYLLIVMLFPLLWTVYISFTNKKIGTPSEFIGLANYWELLTDSMFLKAVLHTLLFTLCSVVAKVVLGTVMALVINEPIRGRNIFRSLLIIPWTLPTVISILIWKWLYSDVGGVLNHILMSMRIVSEPVLWLSDPSMAMFSVILVNVWRGLPFIGISVLAGLQTISHDLYEAASLDGANKWQRFKHVTLPGINSVLYLSALVTTIWTLNDFEIVWLLTGGGPSNATNMISTYSYIVGFINMDVAKAVAVPILFLPFMIYLVNKVTNKTLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH96</accession>
    <name>A0A398CH96_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Flagellar motor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_15300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02123">
        <property type="protein sequence ID" value="RIE02123"/>
        <property type="gene ID" value="D3H35_15300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="9">
        <location>
            <begin position="107"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE02123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="281" mass="30254" checksum="EA401A487069383C" modified="2018-12-05" version="1">MNRLDKTSSLGILAGLAAIIGGFLWEGGHIGGLFEITAVLIVFGGTFAAVAISFPWSRLRKIPDALRLAFRPQVENPAQLIEDMVEYATIARREGVLALETRAADHPNRFLRDGLQMVVDGTDPDLNRQILEVEIDAMEQKLEQQAKIFESAGGYAPTMGIIGTVMGLIHVLGGLADPSTLGPAIAVAFTATLYGVASANILYLPLAAKIRSRIAEQVHVMELMLEGILGIQAGENPNLIRKKLVAFMLMDEADAPVPVKTEESAKENAADKKVTLDAQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHH4</accession>
    <name>A0A398CHH4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_18480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02666">
        <property type="protein sequence ID" value="RIE02666"/>
        <property type="gene ID" value="D3H35_18480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="143" mass="15937" checksum="D3FD6A241BC5BF35" modified="2018-12-05" version="1">MDSQVEHAVDQLKSGGVRMTPQRYAILKYLMESYSHPTADEIYRSLAPEYPSLSVATVYNNLKLFVDAGLVRELTYGDDSSRFDADLSDHYHVICSGCGTMVDFEHPPVKQMEESAAAATGFRIHGHRMEFYGHCPACVGKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHR8</accession>
    <name>A0A398CHR8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01875">
        <property type="protein sequence ID" value="RIE01875"/>
        <property type="gene ID" value="D3H35_13910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017194657" evidence="1">
        <location>
            <begin position="21"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="834" mass="89535" checksum="8FDDC13838D83F0C" modified="2018-12-05" version="1">MAAVLLFSMSGICSAQSAGGASFDARTVAPASEIFGSPAIARDLSKDTSGKGGVKVAVPVPETEASGAAEMKFSRDRSLVGNQSSKVKEDVSKRTRNSRTFVRADGSVRVDQSRYSVNYFSGKEWLPIDTTLRADTSIAGFSYSMLANQFKVRLNHEAGKAAVSFAIGDQAVTYKPVGMKAVKGVVKQDTISYPEAWASTDLVYQVQDDELKMELLLRDAKAPKVFGFEIQTQGVQYRINADQSVDFLNADGQPVFKIPSFWVQDSSSPDRRYDRLEVSIVESRGKTVIQLKLNDEGLKYPIIVDPSTAAIYNTVSSGGSYYLYDNGGRLSQTVSLLGTVDYLYDLNGNLLRRTKSNNLLVNGSFELNTGTTGIADGWNPIYLTPQTVSSPVTSGQKAQKLTASNVMSGYYVGMSQRVRVDGGKPFIANASLNIEALSNATVYLYMDFMDSQNNWIGNSGDAYSGTTGSKYITMTTTGTVPANATYADVYIMVLANANYGSATLYVDQMNFRYDSEPNLLTNPGFEGYSGLGGTADGWIKLSSGSTPYIQVVNESVSEGLRSHKVFDSNIPSGAISGIYQNVKMSGNAAYNLSAVFDTVALTNTKVQLFIDFLNSQHQYIGNNVTENTLLVPNLALSLSGTTPPNTAYAIVYILLRSTGTGGTGTIFADMVNLKYTSAPNKVANGSFEVAGTDPKLAAGWQRAASIFDLVSSPVLSGRRAQKLAGSGIPNGYVVYVCQSIKVTPGALYSTSANVYVESLTNALVRLQINFFDVQGQVVGVNSMVSTTVGNSYDQIYLSNYTVPSNAVRANVLIVLQPIAASGSGTVYIDDVKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIL3</accession>
    <name>A0A398CIL3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_14120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01912">
        <property type="protein sequence ID" value="RIE01912"/>
        <property type="gene ID" value="D3H35_14120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="341" mass="37582" checksum="CC3F00AF8F39EB3F" modified="2018-12-05" version="1">MSVRLSILDQTLLNPGEDPAAAFRQTIELARLAESWGYYRFWVSEHHDSNLVAGSSPEVLISHLLALTSTIRVGSGGVMLQHYSPYKVAENFNVLASLAPGRVDLGIGRTPGGLPHSIQALQKGAVESRPLPDKIEELRAYIQDRPLTKHAIAGLKASPIPRQPASLYLLGASSLSAESAASLGLPYVFAQFINNDEEEAAKAFEAYRARFVADSYSPTVSKPEALLAVPVITADSDEEAQSLADDYRIVRIHLEGGRIITVGSVEHAEEYGRQAEEKYRIEVRPAYVIHGGKELVRKQLLEVRDRYGVDEFIVIATIRDAKKRFRSYELLMEAFSEVPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIV5</accession>
    <name>A0A398CIV5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GGDEF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_16470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02315">
        <property type="protein sequence ID" value="RIE02315"/>
        <property type="gene ID" value="D3H35_16470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017283334" evidence="7">
        <location>
            <begin position="27"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="8">
        <location>
            <begin position="397"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="535" mass="59657" checksum="3DE948A7592A95FD" modified="2018-12-05" version="1">MSASRIRAKGIKLSVIISAIVLLSVAATFAFNTLVGYQTQKRSLYNNTLDLNRITANEMSRTTNTIILSMKDAMKTAAAHFADSYDNEKTIQTEMDFFQKSVPYFNSVALVNEQGRLAARSPEKKSVVGERLVSDAAQQALKLKTPLISEPYTTTTTKRLIVLVSHPIFDSTGHYRGFIAGTIYLQEPNVFQNILGNQAQTENGSYYYVVDSSGILIYHPEMSRIGEKVTENPVVKKIMTGQNGQTAVTNTKGTRYLAGFSIVPSVGWGIVSQTPASNVTKSATEIVAHMAAISAPLVILLLLLVIWISHRLTYPLNRLAYWASKFNRGEGVAPAIPPAKNWNYEANELYRTVSEAFRIMGRRTQELSLEVNTDPLTGLANRRFLDAIVSQWIEEKVPFAVVMLDLDHFKSVNDTYGHQMGDDVLRFLAVWLNSEKREIDYGCRYGGEEFTLLMPYADEEMAFLVAERIRLHMRDEINPIGKPVTLSLGISSFPYSAQDAASLFGQADEALYDAKQNGRNRTVIYRAEKGKSEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIX0</accession>
    <name>A0A398CIX0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01149">
        <property type="protein sequence ID" value="RIE01149"/>
        <property type="gene ID" value="D3H35_22340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="70" mass="8193" checksum="CEA3897BAE8EE915" modified="2018-12-05" version="1">MRPFIGKERDADEFGDYSHPGDTYGLYGRPSDFDFSYPIRQRVGFVRYDGEYGSNKEHVREGRVRGRNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ25</accession>
    <name>A0A398CJ25_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_26925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00818">
        <property type="protein sequence ID" value="RIE00818"/>
        <property type="gene ID" value="D3H35_26925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="322" mass="37249" checksum="0E85F1CA265A6AB7" modified="2018-12-05" version="1">MLLLDKEQIKPDDLVNLAPLECLCSSVLTGLKLAGLNHHLFLVNCWDVQFHSNYLMSCREIEDYEKIDRIYGTRSDFFENGSVEHLEEIFDSGGVAYFLCFASRLSYFPKAFLSYEATGLAHSVLLSRYNKKKNSILLIDSLVDYIDEIHAKDLQSASLLDDKLIYFTQCFSENSKSSSPNLYEIFTDATERNLSVYSKGKGNRGVGALMMFQKETSSSINWDQYSLDKWVDMNKVTMTSIIRMRKYVWNSFQSLGVMSPDFIERGDLLVNEVIRQWNSLIFLMLKYKRNFQNAALIDSIIRKTDDIKNAEIRMLEYLNGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJE0</accession>
    <name>A0A398CJE0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA_circ_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02440">
        <property type="protein sequence ID" value="RIE02440"/>
        <property type="gene ID" value="D3H35_17195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009826">
        <property type="entry name" value="DNA_circ_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07157">
        <property type="entry name" value="DNA_circ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_circ_N" evidence="1">
        <location>
            <begin position="36"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="224" mass="23577" checksum="1C8E39F8ECCB12F2" modified="2018-12-05" version="1">MPCGTASGLRGEAVSAANAVVIGTVELDKVTGILVEEKRKLAVHPWPGSTGDLIQDLGMAAARIRIYGIVSGDGAGDKLEQLRALINKGDSVDFTASAAIPSDVTQVMIVSCQVYQPPGFVNLFEYELELIRYVPVPVTDSGGFHIGSLSSLKDSMHSSALDEISGAVSELGTAKGRLQDIEDVMSATKDSLSLLKNGMNLFSGLNVLRKVISTGQEVVEASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJI5</accession>
    <name>A0A398CJI5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE00998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00998">
        <property type="protein sequence ID" value="RIE00998"/>
        <property type="gene ID" value="D3H35_21320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="181" mass="20430" checksum="58D9426C6901B20E" modified="2018-12-05" version="1">MVEQMAAGTEEALASVDVQQHNILSMNESVRQAVSTGMSLRSAVSQFKLPAENGMTPLSSAIESWMEGALGVRAIMLSMIECRAPEDIRAWNERKLAMEQQLEQRFEELAVHCADSRDSRCLAELREAWESFHRTKDRNAGYMLNGEYEKARQGLTQQGRQLFKAALDHAIQWMEDEPIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJL4</accession>
    <name>A0A398CJL4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4023 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_21490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01028">
        <property type="protein sequence ID" value="RIE01028"/>
        <property type="gene ID" value="D3H35_21490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025097">
        <property type="entry name" value="DUF4023"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13215">
        <property type="entry name" value="DUF4023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="43" mass="4895" checksum="DE32F55C04248EEE" modified="2018-12-05" version="1">MDSTRQFVDKVQDTQRKAKNNKRRSGNGSQGEHLPGKQHSTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK18</accession>
    <name>A0A398CK18_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_18400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02650">
        <property type="protein sequence ID" value="RIE02650"/>
        <property type="gene ID" value="D3H35_18400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005690">
        <property type="entry name" value="GerBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="507" mass="56243" checksum="8D666644CD4C7E39" modified="2018-12-05" version="1">MQRSTALQSELLRNEETLRSIFAECSDVSYRTLLIGDRIEALLIYVDGLSDTDGIEEHVVSPLLRVSYEETVGLDQRLKRLITVSEVQDVSTFEQCEAYLLDGMPILLYEGGASGLALGLTKWQMRGIEEPSAESSVRGPREGFTETIRVNMSQIRRIIKSSSLKMETMKIGEYTRTKIVVAYIDGLVDRTLVEEVKNRLGTIRLDGILESGYIEEMIEDSPFSPFPQLLSTERPDVICGNLLEGRVAILIEGTPFTLVAPITFFSLLQSSEDYYQRFIVSTVVRWLRYMYVALSLLLPSVYVAVLTYHQEMVPGSLVLSMASSREDVPFPALVEVLIMEVSFEALREAGVRLPKQVGSAVSIVGALVIGQAAVQAGLVSAPMVIIVSLTGIASFMIPRYIAGISIRMLRFPLIVLAGTLGLLGIMLGLIAIVLHLCSLRSFGVPYLSTIQTPKLGEMKDVLIRAPWWAMRKRPHLTGHYNQYRQPPGQKPGPDKEGEIGNRRGDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKQ3</accession>
    <name>A0A398CKQ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)H-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_18975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nitroreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02732">
        <property type="protein sequence ID" value="RIE02732"/>
        <property type="gene ID" value="D3H35_18975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02149">
        <property type="entry name" value="NfsB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033878">
        <property type="entry name" value="NfsB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="224" mass="25726" checksum="3D4A784DB58C781C" modified="2018-12-05" version="1">MSDKEAIKQAILAAHHFRHSTKAFDPDRRVSEDDFRFILETARMSPSSAGFEPWKFVVVQNAVLRERLRLVSWGAQKQLPTASHFVIILARRNVRYDSPYIEDLFNNVKKTPPDIFAKIPQIYKDFQQSDFHLLESDRALFDWSCKQTYIALANMMTAAAQIGVDSCPIEGFSFDKVHAILEEEGLLEGGNLDVSVMVAFGYRAHDPKRPKTRQELERIVTWIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL18</accession>
    <name>A0A398CL18_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_08720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04026">
        <property type="protein sequence ID" value="RIE04026"/>
        <property type="gene ID" value="D3H35_08720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="230"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="251"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="799" mass="90727" checksum="8CFD046F9CBEA0A0" modified="2018-12-05" version="1">MIQQGVLKARYGKRSGINVASEQSMRDEEQKRLTEVLEQVEKRLDKELSVLGDRRGDVVGIRQEFWDDVRMNFSDATEMGETWTSIMQQKELLIERERSHRVAFEAVERLARMHDNPYFARIDFKEDGAESAEQIYIGRSSLSSEDGETYWVYDWRAPVSSLFYDQEPGPAAFDTPGGEIIGDLALKRQFVIRGGKLKHVFDTNETVGDDILQAVLSERSDTSMKSIVATIQKEQNQIIRDERHRLIVVQGAAGSGKTSAALQRVAYLLYRYRDSLTPEQIVLFSPNPVFKGYVSRVLPDLGEANMQQKTFRELIEARIGRRFEVEDLFAQTERLAAEEGTAEGEAREKAVRYKGSEHYFRTVEKYLERLSEEGMRFKPWRFRGDVIASAEEMSRYYYGIRASEGFGTRAAKLRKWLLERLASWVESQLDEPWVEEAAELADDEDIQRAYVKVRRKGGFRDSAFDDEEQMAEILMRQAAESAVEPLRRAAKALRFLDPVGVYLELFRSRSLFKACAPDGNLPDGWEWMAARAEETFGRKAVDHEDATPLQYIMDAIEGFRKVEGEIKHLFVDEAQDYSPFQAAYLRRRFPRARMTVLGDFNQAIYVQSQESGGFGGWTRLMAAEDTKVWKLGTSYRSTRPIVDFSKRILPDEDASGIRPFERDGEAPVVTICPDSFELANKIAEDIGRLLKDGHGTIGVIAKTAREGGNAAALLKERLPDEVPVTHVSGGSANLPRGVSVLPSYLAKGIEFDAVVVWDASAVRYGREKDRKLLYTVCTRALHVLHVYSAGTLSPWLAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL19</accession>
    <name>A0A398CL19_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_24960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01598">
        <property type="protein sequence ID" value="RIE01598"/>
        <property type="gene ID" value="D3H35_24960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="289" mass="32604" checksum="B8ACE68497D2821A" modified="2018-12-05" version="1">MNHYEVVENALIHIENHLDQPLSLESVANASNMSKFYFHRLFSAMMGCSLNPYILSRRLNASLELIRTDRLPLTDIAYRLNFGTPSSFTRAFKRQYGIAPSSLRAGHLSIAQSPVPAVVKRPIKNINGDIVTDFTLTEFEPVRLSGIAFEVDLATDDYKSKIRAHSNMLLNELDATVNGPCYVVYSNCQPDSTCFKVLFGVPSGIQIEKPFYFTVDVPQLFCAKFKYSGDLLDIGDVLATDYARFLKVSRQETDDSHIELIQFFDDVHNLDSAYHIYAPIKKLPIDSDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL36</accession>
    <name>A0A398CL36_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_20360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02960">
        <property type="protein sequence ID" value="RIE02960"/>
        <property type="gene ID" value="D3H35_20360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="99" mass="11767" checksum="22AB08BDAA4B4BE4" modified="2018-12-05" version="1">MGLENGGGSEPRLSPSRKVCKDPFIVRSSAQQWDEVPYIRREVQSSAQQWDEVPYIRREVQSSAQQWDEVPYIRREVQSRAQQWDEVTYIRREVRSRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL47</accession>
    <name>A0A398CL47_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_28420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00351">
        <property type="protein sequence ID" value="RIE00351"/>
        <property type="gene ID" value="D3H35_28420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="461" mass="51234" checksum="916BA3316CC302A1" modified="2018-12-05" version="1">MLNLPSRPDENKDIPIGLVGAPELIEPIVLVLRSFPSFRPIVRPAECDEDTVRCAEELLSEVEVLFMTDPDAFRLVKEKLPSPVPMHYLPLSGAGFFKAICRVLMQTVQSSLPLAGVTVDTFPEETVRHMIKGTDPSLSGMIHICDADRSSIEEIYEFHARHYRNGSSSASLSANRRVAERLEQSGVPCVYIEPADNDIVIALERALLSTETRRSKESQIVVGMVVVDNFDSVIRSRASEHEVQKLRLDVQRTMLDFIERLDGYLTPLGPNEFLFFTTRGLFERETGGYKYISLASQAQKRFGLSLSIGIGFGLSANVAGTNARAALRSTKDAGGGTCFIVREDQTFIGPLEMSEPLQYDLSFRDAELLKKVEEAGLTTAYLSRLFASASRHGKLDYTAVELAALLDLTTRSANRLLVQWADAGLAEPREMRKAGRGRPTQVYVFTFMREHLSEHGISLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL62</accession>
    <name>A0A398CL62_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Magnesium transport protein CorA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">corA</name>
        <name evidence="7" type="ORF">D3H35_09025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mediates influx of magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04076">
        <property type="protein sequence ID" value="RIE04076"/>
        <property type="gene ID" value="D3H35_09025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004488">
        <property type="entry name" value="Mg/Co-transport_prot_CorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00383">
        <property type="entry name" value="corA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="311" mass="36486" checksum="37C2BD40BD6A806D" modified="2018-12-05" version="1">MKIRLVQNGVFTTVEDVSEALIAPAEGFYWIDADDEDLVVLQPLFGLHDLAVEDCLTEEEQRPKLEVYENQYFLVINSIRFDDEEIFLRALNIFLGRHYLITVTRQKINELRSVKPVLWEQEVNRPDRFLYHLVDIVVDNYFTVGDRIEARIERLEEDILMHTKKSHLNEIIGLRSEILWLKKVLGPQREVIGILNKRDLRLIDDQLQKYFGDIYENAVKIFETFETYRDLMGNLREAYQSSLASRANDIMRVFTALTTIFMPLTFITGIYGMNFDYIPGMHDHYGSVALLVVMALLGVGMFYLFRKKDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL77</accession>
    <name>A0A398CL77_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01658">
        <property type="protein sequence ID" value="RIE01658"/>
        <property type="gene ID" value="D3H35_22255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="34"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="313" mass="34698" checksum="E17EB95778481971" modified="2018-12-05" version="1">MGSMPTNNDALPDNVLKWVLNAVHPKAAYRESRQLQGGISSLVHGVSLDVHGEEINVVLRQFDNADWVRNQPDVALREAESLRRAARAAGADTPRLIAFDETGSQCGAPALLMSRLEGHVVLDPPDFPQWLDGMARAIVRIHAVEPDDFPWTYSPYTDSSTLDTSSWSKHPDKWQAGVAIVKGSRPKFANRFIHRDFHPANILWSGGEVSGIVDWVNGCIGPAGIDVGHCRVNLAQLHGVEAADEFLARYRSHAGDAFVYDPYWDLVVLLDYAYGPPPEIYAGWTALGMTGLTNEMMRERLDEYLLSLLNRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL89</accession>
    <name>A0A398CL89_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04116">
        <property type="protein sequence ID" value="RIE04116"/>
        <property type="gene ID" value="D3H35_09245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="121" mass="13269" checksum="9BB5278DB8202F13" modified="2018-12-05" version="1">MAKIHERQQELGRPVRLELGIERAAFRIDLVVVGINTSASLCSSTYAANSQRVRRQFVVLIQEDKKFSEAIDAALFEAALILPLLSLNSAECGRPSSAFADHRFDRRIGAGVVDDAQLQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLF4</accession>
    <name>A0A398CLF4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flagellar hook-basal body protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_14735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02019">
        <property type="protein sequence ID" value="RIE02019"/>
        <property type="gene ID" value="D3H35_14735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="2">
        <location>
            <begin position="5"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="3">
        <location>
            <begin position="211"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="292" mass="31380" checksum="79878A4DB6A57C64" modified="2018-12-05" version="1">MLRGLYTASSAMVAQQRRHDAVTNNIANLNTPGYKESGAVTRSFPDMLISALGGDIGSDNKVGKLSTGVFAEENLLRMSQGDLQETYRPSDMAIVSDILVDGVAFDASGKYVDPESGEVTYQPQAFFTVEGANGEPLYTRDGSFKTAVDGTLVTSSGNPVLGADGQPIVVTGAWEQVSITADGRLVSTATGLPLAGEPRLMLTRVDNPNLLVRQGDGTFQYKGEAGDIRQVDPADVNTRVQIRQGFLERSNVDSAQSMVDIMSALRSYEANQKVIQFYDRSLDKAVNEIGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLG9</accession>
    <name>A0A398CLG9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA topoisomerase 1</fullName>
            <ecNumber evidence="10">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">topA</name>
        <name evidence="12" type="ORF">D3H35_11325</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="10"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03275">
        <property type="protein sequence ID" value="RIE03275"/>
        <property type="gene ID" value="D3H35_11325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="zf-C4_Topoisom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="10">
        <location>
            <begin position="163"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE03275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="699" mass="78500" checksum="80196EADBEDCA359" modified="2018-12-05" version="1">MADSLVIVESPAKAKTIGKYLGSKFIVKASMGHIRDLPKSQIGVEIENDFTPKYITIRGKGTVLKDLKDASKKVKKVYLAADPDREGEAIAWHLAHYLELDEKDACRVVFNEITKQAVKDAFKAPRPIDMDLVNAQQARRVLDRLVGYKISPLLWKKVKKGLSAGRVQSVAVKLVIDRENEIKEFVPEEYWSITAHLSKEKAEFEAKFHAVNGEKKELGSEAEVKEVLALLKGEAFSVGEVKEKERLRNPSPPFITSSLQQEAARKLNFRASKTMQIAQQLYEGVDLGTEGTVGLITYMRTDSPRISEIAQTEAREFIAGKYGVAFVPETPRVYNKKNANAQDAHEAIRPTSVLRDPESVKSFLSRDQIRLYKLVWERFLASQMASAVLDTMTVDLQNGPVTFRATGSKMKFAGFMKVYVEGNDDGTSADEERLLPPLAVGDAVKSSSVDPKQHFTQPPPRYSEARLVRTLEELGIGRPSTYAPTLETVQKRNYVAIEEKKFVPTELGELVIQLMEEFFPEILDAEFTANMEGDLDHVEEGKENWVHVIGDFYKSFEKRLTVAEDEMKEIEIRDEPSDEVCDKCGSPMVYKMGRFGKFLACSGFPDCRNTKPIVKDTGVTCPKCKEGKIVERRSKKGRLFYGCDQYPGCDYVSWDKPVAKPCPDCGALMVEKRTRAQTQWNCTSCTHSEEAPDIEEAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLM8</accession>
    <name>A0A398CLM8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_06415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04246">
        <property type="protein sequence ID" value="RIE04246"/>
        <property type="gene ID" value="D3H35_06415"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="3">
        <location>
            <begin position="21"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="4">
        <location>
            <begin position="218"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="339" mass="35896" checksum="08302B691184F79E" modified="2018-12-05" version="1">MLQSFQKSITDKGCCLAMSEWAVVGGGSLGLLLAGKLAAAGCRVVLWTRTSEQAERIEADGIAIEEMSGVVSQPVRLRAIPISSVKGIHEGPILLTVKQTALDSELYSFLRLATGGAGRIYLFQNGVGHVEKLARALPGTTLTPAITTEGALRLGPSSVRHTGKGAIWFGVVGAAELLPMPMTTGIDSENALFADSSVRNVAEMMKQAGFTVFLSNELEKRVLRKLLINSVINPLTALLRIPNGQLLKTPERLSLARELFDETAKVLERSGLPDAANAWDEVAAVCEATATNLSSMLQDVQAGRATEIDAINGAVCRLAERNGLEAPLNAAVTALIKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLN5</accession>
    <name>A0A398CLN5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stage V sporulation protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_06465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transpeptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04256">
        <property type="protein sequence ID" value="RIE04256"/>
        <property type="gene ID" value="D3H35_06465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011927">
        <property type="entry name" value="SpoVD_pbp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02214">
        <property type="entry name" value="spoVD_pbp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="579"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="640" mass="69708" checksum="B24F0437652A62E4" modified="2018-12-05" version="1">MKVSQVKVRRRLLTALIVLIAAFSALVLRLGYVQLWKGGELSLMAEENWRRGIPFEPKRGEIVDRNGTRLAYNVSSPTVYAVPVQIKDKPGTAKRLSGILGMSEELLLKQISKQARDVRLSPGGRKMTLEKAQEVRNLRLPGIYVGEDNKRFYPYGSMAANVLGFTGAFNDGLTGLELKYDKLLTGLEGRVSFLTDAAGRQMPNSSDKYVPPKDGLTLQLTLDQTVQSIVERELDQAMLQHQAKSVIAIAMNPKNGEILAMGSRPTFEPDKYQEVPTEVYNRNLPIWMTYEPGSTFKIITLAAALQEKKVDLTHERFFDPGFVEVGGARLRCWKKGGHGSQTFLEVVENSCNPGFVALGQRLGKEKLFSYINAFGFGQKTGIDLMGEENGILFKPSRVGPVELATTAFGQGVSVTPIQQITAVAAAVNGGNLWKPHVSKGWIQPETGAVLESVKPELVRQVISPEVSAQVRDALEKVVAQGTGKNAFLEGYRVGGKTGTAQKVINGRYSPNEHIVSFIGFAPADDPQLIVYVAVDNPQGIQFGGIVAAPIVRNIMADALPYLGVKPRTIQVEKEYKYGDTPILKVPNLVGKTVSDIYEDMSMDFQLAASGSGATVIRQAPAAGSKVEKGAVIRIYLGAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLZ4</accession>
    <name>A0A398CLZ4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HPr family phosphocarrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04366">
        <property type="protein sequence ID" value="RIE04366"/>
        <property type="gene ID" value="D3H35_07175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPr" evidence="1">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="79" mass="8556" checksum="30623E7504FFA301" modified="2018-12-05" version="1">MSNNAAIVELSQTANKFRSSIVLQAENKYIDVKSILGLFTTLVGGLSYELHVHGPDAEEAKKELAAVFSKHNLNVAVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM35</accession>
    <name>A0A398CM35_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FMN-dependent monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_16265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02279">
        <property type="protein sequence ID" value="RIE02279"/>
        <property type="gene ID" value="D3H35_16265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="149"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="221"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="445" mass="49134" checksum="EDEA18C4FAA30E7F" modified="2018-12-05" version="1">MSRPNEQMSLGAFLFSFGHHFAAWRYEGTKTDGVIDMNFYKEIAKTAERGKMDMLFLADGLSLPDKADVASNVSAVYPEATTVITALAGVTERIGLAATLSTTFNEPFNVARRFATLDHLSGGRAAWNVVTSTKNSDARNFSGRDLPEHGVRYERAEEFLDIVTGLWDSWEDEALLFDKASGAFADPSRIHQISHEGTAFSVKGPLNIPRPPQGKPVIVEAGTSPSGQRLAAKTADVVFTACEDKEEARRFYAGLKAQLPEFEREPHELKVMPGVLTFIGDTESEAIEKEAELSELISPDAVVANLSRMVNVDLSGYPIDGPFPDIPLKGNSSRAFMVADLARQRNLTLRQLGFHFSVARGHLVLRGTPEQIADQMEDWFVSKACDGFNVMPPYLPGGLGEFVDKVVPLLQRRGVFRTEYAGRTLRDHLGLNRPANRFRRLPAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CML4</accession>
    <name>A0A398CML4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoside recognition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_03680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04606">
        <property type="protein sequence ID" value="RIE04606"/>
        <property type="gene ID" value="D3H35_03680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Gate" evidence="3">
        <location>
            <begin position="43"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="231" mass="24108" checksum="E0B1D117AB21354A" modified="2018-12-05" version="1">MVNWIWLGMIVVSVVFAAVTGRMNEVAEAAFGGAQTGVTVCLGLVSILVFWMGLMRIAEDAGLVRKLSALLAPIVRRLFPDVPKDHPAMGYILSNMSANLLGLGNAATPMGIRAMQELQKLNSQPHIATPAMCTLLALNTASITIVPTTIIAIRMNMGSAHPADIVAPTLLATAISTAAALLADRWYRRKSGAPPIARNKAGSKRRPPKGPLSGASLSPSGVPPADKAIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMN8</accession>
    <name>A0A398CMN8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iron-hydroxamate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_22460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01167">
        <property type="protein sequence ID" value="RIE01167"/>
        <property type="gene ID" value="D3H35_22460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017425625" evidence="2">
        <location>
            <begin position="27"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="70"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="330" mass="35156" checksum="687D8CE1A2E83BBE" modified="2018-12-05" version="1">MKNKPLVLIISLAILIVLSACGQTSGSEKPEASPTPSASPTAGSSAPAADAGSSSSAAADEILKNNPNAKIASISIHITNNLLALGITPVGSVVGGDVKDFLPHVKDRLAGAAKLGVVTDPDMEAILSLKPDVIFIDSVYSGKDRAKFEQIAPIIAIDMDAGTWRDHLQTIAGHVGHEAQAEAFIKNYDDKAAKVSKLIHSELGEGAKVMAIRSTAKELRVMGIKRPVGPIMFDDLALKPANGVEKIDKAFEVISQEVLPDFDADAIFVIISKGNEAMNNYTSLEKSALWSNLKAVKNRHVYVLDGQTWLDYSSIGQDFALDDAERLFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMT2</accession>
    <name>A0A398CMT2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_10940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03550">
        <property type="protein sequence ID" value="RIE03550"/>
        <property type="gene ID" value="D3H35_10940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="225" mass="24424" checksum="443316862C4359CD" modified="2018-12-05" version="1">MLQLENVVKSYTVEGKRQVRVLDIRSFGMAAGEKAALVGPSGSGKSTLLHLLSGIIRPTEGTIRLLDRRLETLAEAELDRFRACHIGYVFQSFNLLPGFTAIENVLAAMQFGSSALTGKEKKERAAELLDQVGLGHRLRHRPAQLSQGEQQRVSIARALANRPALVLADEPTASLDAANAGNVFELLANACKEEGAALLLCTHDSELAGRMDRIVRIRELSREGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMU4</accession>
    <name>A0A398CMU4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_15220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02108">
        <property type="protein sequence ID" value="RIE02108"/>
        <property type="gene ID" value="D3H35_15220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="200" mass="22335" checksum="3D3C3161B98A99C9" modified="2018-12-05" version="1">MKGEDNKREKIIEAAYQLLAEGGYDQSSTKEIAKRAGVAQGLINYYFQSKSLLLAEVARRETIRYCESFDDMTSFYGKPVNAELIRQLLMLSKNRAMDNPDWFRLRYELAAIGLREGEASGLLKETMDVKRAHLARLVEEVGRLPTELSKPLSSILLSVFEGVGLQKLADPSFDMDGAYAMLGDMLAVYFESLQSKSGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN16</accession>
    <name>A0A398CN16_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_10590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000033">
        <property type="protein sequence ID" value="RIE03630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03630">
        <property type="protein sequence ID" value="RIE03630"/>
        <property type="gene ID" value="D3H35_10590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017293505" evidence="2">
        <location>
            <begin position="31"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="302" mass="33608" checksum="D9C01E945F025C0C" modified="2018-12-05" version="1">MLKTSKKFGKSSAIMLATAMSFVLILSACGNDKNKTGGNEASPVPPSSESASPTASESSSPDTKLSDYNLTLFLPGTTPKDEQKVEAEINKYLKDKINATLDLRFVDWGQWDNKMNLAIASRDPMDIIFTAAWNGHAANVAKKAFLALNDPNGPKGNLIEQYGQDITATLPEQFLKGAKIDGLNYGIPSNKELAEQGGIIYRKDIADELGLTDKIEAVKTIADLEPILAEVKAKKPDMIPVFMRDGENFNAHYFFQIRLPRRQHDRRRRHEGRHGYDGTGPLRPRATKKRWRLPAIFSKRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN29</accession>
    <name>A0A398CN29_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small acid-soluble spore protein P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01317">
        <property type="protein sequence ID" value="RIE01317"/>
        <property type="gene ID" value="D3H35_23335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012614">
        <property type="entry name" value="SASP_SspP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08179">
        <property type="entry name" value="SspP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="49" mass="5449" checksum="6FECB61DF6F6D4CC" modified="2018-12-05" version="1">MSKPKTQPVPQPGEHNAHDLDRGHQPNEPLSGSKKVKNRNHVSHHNPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNK0</accession>
    <name>A0A398CNK0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 11">Trigger factor</fullName>
            <shortName evidence="9">TF</shortName>
            <ecNumber evidence="9">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PPIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tig</name>
        <name evidence="15" type="ORF">D3H35_08000</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="9">About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the FKBP-type PPIase family. Tig subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="9"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03902">
        <property type="protein sequence ID" value="RIE03902"/>
        <property type="gene ID" value="D3H35_08000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00303">
        <property type="entry name" value="Trigger_factor_Tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003095">
        <property type="entry name" value="Trigger_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="SSF102735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="14">
        <location>
            <begin position="163"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="361"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE03902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="429" mass="48061" checksum="ED245CB1DA1E446A" modified="2018-12-05" version="1">MKANWEKIENNVGVLDVEIEAEQVAQALDKAFRKVVQKVNVPGFRKGKVPRTIFEARFGVESLYQDAIDILLPEAYTNAVNEAGIEPVSRPDVDVEQFAKGQSFKFKAKVTVKPEVKLGEYKGLEVSAPELEVSEDEITKELERLQQRHAELVVIDEGPAQQGDLTVIDFEGFLDGVPFDGGKGDNYSLELGSGSFIPGFEDQVVGLNIAEEKDIEVTFPESYHAENLAGKPVVFKVKLHEIKRKNLPELDDEFAKDVSEFDTLDEYKQDLTSKLSERKAKDAESSKESAVVDKASENAELEVPDVMIESEVEQMFKDFENRLRQQGMNLELYFQFSGQDEAALKEQMKGDAQKRVRNNLVLEAIAKAENLEATEADLDEELENLSKVYNRSADELRSIFAANGYLENLQADLKVRKAVKLLVDSSKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNP3</accession>
    <name>A0A398CNP3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_06285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04223">
        <property type="protein sequence ID" value="RIE04223"/>
        <property type="gene ID" value="D3H35_06285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07484">
        <property type="entry name" value="Peptidases_S8_Thermitase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034084">
        <property type="entry name" value="Thermitase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017468451" evidence="6">
        <location>
            <begin position="26"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="343"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="621" mass="67503" checksum="1F70DC78232B361D" modified="2018-12-05" version="1">MRRRYALLGLLFTAAVALFVVPLFAPPAARTPSPPSTSSLKQAAASKELTYKHSSIKRDMQETERLSRKQSVRDAVQYLDGKSDATVAARTGSLERLLRTHPEMQAVAWVKGSQTVAAGSPAQGLRKAAEPYWKHGENAIRSGRAYTSSLFAYEGKSHFVLAQPASDGKSGLVMLLSASVVQEVERHQRRNLRVVPYPAEGRYRIESVLPNTTKDITVKTGEDNGNASHYSVDEVVVKFKKPLDNRQLLQIRKELHLTVVRHLKQTYVFRSKKHSAEQLMKYFQKYDPVYVEPHYLYLTNELPDERAANDSSTIVPNDTLYSEYQWNLPEIATEQGWNVSKGSKDIVVAVVDTGVQSDHPDLKGRLVAGTNIVDPSSPPDDDVGHGTHVAGIIAAEVNNGEGVAGMTWFTKIMPVKVLDSTGAGSTYSVAEGVVWAVDHGANVINLSLGNYADAEFMHDALKYAYDHGVVLVAASGNDNTDRPGYPAAYPEVLGVAATDPNEARAEYSNYGDYIDIAAPGTSIASTYPGSRYASLSGTSMACPHVSALASLVRAANPKMTNAEVMDVLRRTAKDLGSAGKDASFGYGQIDVKAALQAAGGTSSSLQLYPRQVKRDLERIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNR8</accession>
    <name>A0A398CNR8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04135">
        <property type="protein sequence ID" value="RIE04135"/>
        <property type="gene ID" value="D3H35_08690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipase_3" evidence="1">
        <location>
            <begin position="59"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="252" mass="27445" checksum="3B4CE8165D03F435" modified="2018-12-05" version="1">MGKAIFLAAVCSQTYMQFSQNGAFIVPTDYSPVGSFTAESLGGGRELFGFILESERDAIVAFRGTSTTEDWITDAMVAQVDYKWVKQGGLVHRGFARVYGSAREQILAALNRMQGDKPLTITGHSLGGALAVLCAPDVSANSRFRLPCVYTYGAPRAGDPAYAKTFGSRAGASFRVQNVYDAVPHLPPFIMKLPRRGKVYYYSHVRREAPLDFQNGSVSANHVISSYFNDLAGKDPAYAKRMCARNPGFCPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNW5</accession>
    <name>A0A398CNW5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SMC family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_06130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04195">
        <property type="protein sequence ID" value="RIE04195"/>
        <property type="gene ID" value="D3H35_06130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="3">
        <location>
            <begin position="6"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="492"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="739"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="822"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1160" mass="128529" checksum="176653C8F5712FCD" modified="2018-12-05" version="1">MKPIGLELSGLQSYREKQYVDFDKLCEGGIFGIFGPTGSGKSSILDAMTLALYGKVERAAKGTQGIMNGAENKLTVAFTFELSDSKETMRYRVERQYKRAGDVSVHGAICRLVQVKLEGDIVLADKQSDVDAEIERLIGLGMPDFTRAVVLPQGKFAEFLTLAGKDRRQMLQRLFRLERYGDVLSGRLSRRADAVKLSLKETEAEQLGLGDASPEALAEAETRLAAAREAANLLKLRLAAAEAAHTELTRRRELHTQLERIERELAAHRLRSDEMKEKERRLHLLEQAQAVAPFLSDVEDADQELAAGRIAKAEAEAELARRAAEAAEAAADWLARAAEAERTEPELLVKLERLEQAIRLEGELADWARQSTELASSLEEAAADKRSADASAAVSSDKLARARTKQSAIKEQLDRTAPLAEASSRLQTASSRKERLDALMREARESGVETATAKEQELRAADRLRRADEFVLAAAAEGAQLRYWWKKADEELAAVQQRIHRWATELQNEEERQRAEERDHERRHLARLLTERLVDGQPCPVCGSSDHSGVAVHDSSKELSVDWEAMRAELSARSARLAQLKRETDGWRTKSEWHLARVSEAIRASVSASASPKEDIELGREDESSFIRLAERYDDPSFSQALSEAAVGLEKADSAGFDIVWREWSRFDSQLIENADRTSMWESDWSGANRERAQAAEAHAGALQAAAIAETKSNRRSEEANAFLTAWSAEFPDLRLESVEDEAAAAARSEAETKELRERLATSVGFIEEQEAKLKELERRSTEMAIRQAELNARLQNVEASRLSVSERLREWTGGQSAGQLQILARQELESLRRTAAEAKTQAEASEKRSRDAAALAAVAADREATAVSRQERAAVRLMESLSGRFDSAADAKRLIPAIPEAPFMKRELDDYKQHEAQLAGQYRLMKENAAGDPVPQNIWEASAASVDSLRTETDIALASAAKSERDSDDLKARRDRWEQLESSRVRFAADASRIAQLQSAFRGNAFVEYIAEEQLEQVCVAASERLGFLTSRRYALEVDAGGGFVIRDDANGGLKRPVSSLSGGETFLTSLALALALSVQIQLRGKYPLQFFFLDEGFGTLDPELLDTVITSLERLQHSLLSVGVISHVPELQARLPRKLHVTPAEPGGRGSRITFESM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP16</accession>
    <name>A0A398CP16_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_20760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03029">
        <property type="protein sequence ID" value="RIE03029"/>
        <property type="gene ID" value="D3H35_20760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="92"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="322" mass="37167" checksum="969B4D1DB4F2E7BD" modified="2018-12-05" version="1">MKAMSGVAIPQGKSQTPRKGSGFWFRFYQNRYLYLMSLPFVVWVFIFSYLPLWGWLMAFQKYKPGKSIFEQQWVGFEQFKTLFQDDTFYLVMRNTLAMSFMGLIAGFIVPIVFALLLNEVRHMFFKRFVQTISYLPHFVSWVVVSSIVSKMLSTDNGVVNDLLMWLGFIDEPIQYLAQEKLFWGIVTVSDVWKEMGWNTIIYLAAISGIGAELYEAARVDGASRLRQIWHITLPGIRSTITILLIMSIGHLISIGFEKQFLLGNNMVRDYSQVLDLYALQYGLQMSRYSFGTAVNIFNSVVSVILLFTANGLFKRFTKESIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP21</accession>
    <name>A0A398CP21_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_06805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04313">
        <property type="protein sequence ID" value="RIE04313"/>
        <property type="gene ID" value="D3H35_06805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="92" mass="10951" checksum="8DE66F662D550094" modified="2018-12-05" version="1">MTRQRHLNNEELAVETDIAPNKIRAWIRSGKFKIYDYPNLADNCDLCRAPIRSGKLCYSCTTRIKDDVEKVYQQERLMRERLRQANAYISRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPC6</accession>
    <name>A0A398CPC6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04433">
        <property type="protein sequence ID" value="RIE04433"/>
        <property type="gene ID" value="D3H35_07565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="516" mass="57769" checksum="5A481E59B2BC00A6" modified="2018-12-05" version="1">MLDTNGLDQLGFANMSFQNGGTPSAEGSPDDSNNGLVAAGLQRYHRDVVAASLEYQIGESNRACWNHGDSNDGSTTCNQTTFKDKRALIFIENTIPETLTFVKYWNDNKGGAGNWYIEPNADDTVPPDCKRIFVLKDNDRAGLYFKMNYIEFHMSFTCPKMSSNSAEGSPHTGLQTYSGSGTPVTFTYRVGTPNLACWSSGTSNSGKTVCPQTLVLPFDLRRWMGKVNEKYAGFKNQKLRQLFIPGTHDAACYNNSGVATPWVQTQQVNFHDQLMLGARYFDVRPKYVHEGEGEWSHGFHHGPITVAATLDDLISQVTAFYTEDWQKRQNEIIILDFTHFDNYDDKERPGALQSFFTALYNSSLNPYLIPQGSFGPNTTLNSLWTASTQQRVIASVNFDPSSYQNTGNIWNGKKLFADEWDGSKFWPNTDKQTDLIQFINNNISTFSALTNLWALQDLLTPGLTSSVYSLVDQAHGALYGPSGLSWRSQANIVIQDYYDDRTTIEAIIENIRRISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPI1</accession>
    <name>A0A398CPI1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_08985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04070">
        <property type="protein sequence ID" value="RIE04070"/>
        <property type="gene ID" value="D3H35_08985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="113"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="176" mass="19938" checksum="1E9241411CBDA3FD" modified="2018-12-05" version="1">MSFLREPDPIHSLWTEEEVMGELYRQMLRVARSKLYNKGDAGDVVQEAWVRILENGHSLREADKLFPWARTIASNLASSANRSRRRLETVYEGYAEFLRGGSQSAEPELIAVLSDALGRLDPATRTLLLYKFYYGFKDDEIATALDVPVGTVKARIHRSKARLKSNSNDEGYPSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPL0</accession>
    <name>A0A398CPL0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division protein ZapA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">zapA</name>
        <name evidence="3" type="ORF">D3H35_09210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04110">
        <property type="protein sequence ID" value="RIE04110"/>
        <property type="gene ID" value="D3H35_09210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007838">
        <property type="entry name" value="Cell_div_ZapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036192">
        <property type="entry name" value="Cell_div_ZapA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029605">
        <property type="entry name" value="FAM184"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870">
        <property type="entry name" value="PTHR18870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05164">
        <property type="entry name" value="ZapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102829">
        <property type="entry name" value="SSF102829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="581"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="677"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="70"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="702"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="887" mass="100379" checksum="E5CC101258CF96C6" modified="2018-12-05" version="1">MNGNDGTRVTVDIYGTQYSLKGHSNPDHMKKVAALVNDQMNKIAGGTNRLDLTRLSVLAAVNVADELITAQVDMERLRQAEADIERLSNELSELSVNSEAELKEARLELAAALDKSKRDFETAFDAEKTRHADELALANRSLEEAKKALARSSEEHRAEVAKLRGAHAAEADELKKGREAEIGRARRELEGVRQQFAAKLADTRKECDGKLADMRRSHAEETQRLRREGESALGRVQSEHSSELERIQGERKSELEQLQGGHESELERVHSEHKSELEQLQGGHKSELERVHSEHESELEQLQGGHKSELERIQGERKSELEQLQDRHESELERIHSEHKSELGQLQGGHKSELERIHSEHESELEQLQGGHESELERIHSEHKSKLEQLQGGHESELERIHSEHKSKLDAVRVAHEERLKTAAVSHSEELEASKRASGDELEELRRSHAKELIEIAESHGDELTAIKGSHAQEIDAIAVMHAAELTAAKQAFAAEHAEIVRVLETKLQAAKTEYESLEMAHKSEYESLELSYMTELESLELSFKSELESQKSAKESELAQFKGEHAAKLESVRTESLAERSAELESLRNEHQSELSKQREDHAVQVKSLKEEYSSEMEVLSAVYSDEFAGIRSEHADQLERERLAHREELARITAANTAQLADLRFDLELKLEQERADHDEHAQSLHKQLAGERDAASGQFDMARRELEEEKAAIAAERDEWREREQEWQSLRGKLESDSNHWAREAEELRSKLRETEGREESALESTLILEEMVSSAERERTAAEQRAAVLQARLDELDNAKEHLSEAAKLAASELEAARAQAAALDAREVEIAEALDQAAADSERTSRLEISLSSLEREHEELKKEYSKLQSEFNEWIDLLESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPP0</accession>
    <name>A0A398CPP0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Inhibitor of sigma-G Gin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01421">
        <property type="protein sequence ID" value="RIE01421"/>
        <property type="gene ID" value="D3H35_23930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019700">
        <property type="entry name" value="Sigma-G_inhibitor_Gin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10764">
        <property type="entry name" value="Gin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="61" mass="7309" checksum="E16944CE3C77A3EB" modified="2018-12-05" version="1">MEPIERKTCIICGEQKEEGIKVVTEFICVSCEREMVSTKVEDRKYPFFVQQLKQVWVRFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPT3</accession>
    <name>A0A398CPT3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OTCace_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_00630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000006">
        <property type="protein sequence ID" value="RIE05426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05426">
        <property type="protein sequence ID" value="RIE05426"/>
        <property type="gene ID" value="D3H35_00630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="109" mass="11591" checksum="7955BF0C8620A6BB" modified="2018-12-05" version="1">MTTLFFEASTRTRLSFESAMNGLGGSVIGTENAAQFSSAIKARRLRIRSKSLPATAMSSLCGIRTSAQPKSGQGIGRTGHQCRGRRGRAPTQALLDAYRSARSLARSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ37</accession>
    <name>A0A398CQ37_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_03835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04633">
        <property type="protein sequence ID" value="RIE04633"/>
        <property type="gene ID" value="D3H35_03835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="196" mass="21366" checksum="7F1FB91849743997" modified="2018-12-05" version="1">MKGGYSGAALAALADRLESCGAHWVVGGSTGLSIRGAELDRAPRDLDIYTDENQIPIMHAKLMELAMDMPTLSETELYRSVLAHYNAEGTVVELVGGFRVTALSSSYRTDVSAILYPQGDSVQIDGREVRLVPLGHELLFNLLREREDRAEAAGSLMRLEPEKHFPVLEKLLAANSISPEVAAKARRYAGGREDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ60</accession>
    <name>A0A398CQ60_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">Phosphoenolpyruvate-protein phosphotransferase</fullName>
            <ecNumber evidence="6 15">2.7.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 15">Phosphotransferase system, enzyme I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ptsP</name>
        <name evidence="22" type="ORF">D3H35_07060</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 15">General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="6 15"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04350">
        <property type="protein sequence ID" value="RIE04350"/>
        <property type="gene ID" value="D3H35_07060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024692">
        <property type="entry name" value="PTS_EI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006318">
        <property type="entry name" value="PTS_EI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000732">
        <property type="entry name" value="PTS_enzyme_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47831">
        <property type="entry name" value="SSF47831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01417">
        <property type="entry name" value="PTS_I_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 15 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 15 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="22" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="15 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PEP-utilisers_N" evidence="21">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="19">
        <location>
            <begin position="155"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="20">
        <location>
            <begin position="256"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="PEP binding" evidence="17">
        <location>
            <begin position="455"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="16">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00016544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF05524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RIE04350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="586" mass="64855" checksum="D2B8762A23D8C23E" modified="2018-12-05" version="1">MIQALGASNGIAIGKAFVLPHWEWELPDQKIDVADLAKEFERLYEGIRRSKTEIALMKTELDETVGVSEASIFDAHLAILDDPIFMNEIQGIIQRQYKVAEVAVKEAIDHFVTMFDLLDDEYMKERALDIKDVGNRLLKHLLGAPEIALPEDTQPFVLVVRELSPSQLIHLRPELVLGIVTMVGSPTSHSAIMARAFGIPLVMGVDGKLEEPIETGELIIVDGGAGIIHVGPSGETVLRYSEIRKRQLEEREQLLTIAELPSVTPDGHKLILAANISSIKEMEAALSNGAEAVGLFRTEFLYMDRNHFPSENEQYEVYRDVVKMLDGKQIIIRTLDIGGDKQLDYYEMPVEDNPFLGYRAIRFSLDRKDLFKVQLRAILRAAVHGDMQIMYPLITSVEEVREANALLAEAERELEAEGVPFRGGIPTGIMVEVPAAVAIADLLAEEAAFFSIGTNDLVQFTLAVDRMNENISHLYEPFHPAVLRMLRTVTEAAKRKGIPVSVCGELAGDVRALPILLGLGIEELSLSAQAILPVKEGLLRTSAAESRLFLEELFRLPTVGQIRQAAEKFHAETTLSASPGRVYPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ78</accession>
    <name>A0A398CQ78_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_22235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01134">
        <property type="protein sequence ID" value="RIE01134"/>
        <property type="gene ID" value="D3H35_22235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004761">
        <property type="entry name" value="Spore_GerAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34975">
        <property type="entry name" value="PTHR34975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03845">
        <property type="entry name" value="Spore_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="373" mass="40351" checksum="FB681CEED8B602E6" modified="2018-12-05" version="1">MENRQSNLTQGQMVSLLIAFSTGSAIIYIPGTLAGIAGNGAWVSIAGSSGFGMLVLSCILYLHRRHNGAGLVDYCRKLLGKTATGLVMIPVAAMLLFAIPAILTGIGDFFARGMMPRTPTFVFCSLSMLAAALTARAGIKVTARMFVLLVPVMIVFTVAVLFFALPLYDWGRLLPFLDKGTGSALHGFFVAAGFPFGEVCLFSVILSSSPQEGGRSFYRKLYWAFSVTGILMVFSTICTIIAFGPAAGHLTYALYQLASNIVFSGINERVEAVIGIALILGSYMKATIFLIALNRILIRLTGTDDEQAYIYPIGLICIFLSLTLFASPAEFQRQVYTLWPFTVVGVGCTLVFALAGLTWVRERLRHQPEEKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQE8</accession>
    <name>A0A398CQE8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_20700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03018">
        <property type="protein sequence ID" value="RIE03018"/>
        <property type="gene ID" value="D3H35_20700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033480">
        <property type="entry name" value="sCache_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17200">
        <property type="entry name" value="sCache_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01049">
        <property type="entry name" value="Cache_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="231"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="10">
        <location>
            <begin position="303"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE03018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="589" mass="63513" checksum="6C1701CFEE418CF6" modified="2018-12-05" version="1">MRTMTNTFAAGKRMLTIRKKLLFVCSFLLIVPIAALGLATYQVTDEETTALIENGLKNNVRLASEMLGVLDKAVQDGLMTKEAAQERFKSSLLGERLTDNTRPINRNFDLGDNGYFFILDDKGLLLAHPLLEGQNIWDKKTSDGTYYIQDLLKKAQEGGGFTYYDWPLPNSDKEAEKVAYAERADAWGWTIAAGSYMKDYNSGQRHIVNVIFLTLGICLAGGAILLTLFAQHISRPLIRMAGQAERIASGDLTGEAYVPKRQDEIGTLAVAFQHLQNNLRELAGNQSLSAGSLASSSAHLSDVISETVGAANETTRAITELAAHNETQVHSIEETSRAMEEMTIGIQKIAASSVTAFDASSRTLAEAEKGHILIVRSSEQMNDVSGTVVDLSSVVHRLGDRSEQIGEIAGAISELAGQTNLLALNASIEAARAGEHGKGFAVVAGEIRKLAERSNESAAKVSGLTEAIRGEIGYAIESMRKSEREVQTGVASIQETGEAFARILQATRSVAAQVEEASAAAEEMSASSQEIAAALQQMERVSSTTAEAAQTISGATEEQLASLEEIEESAGRLRTMSDDMKRQANKFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQU0</accession>
    <name>A0A398CQU0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclear transport factor 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01791">
        <property type="protein sequence ID" value="RIE01791"/>
        <property type="gene ID" value="D3H35_13405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017354493" evidence="1">
        <location>
            <begin position="26"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="152" mass="17051" checksum="70685BE7DD777210" modified="2018-12-05" version="1">MLKIRMLAIPVIFALTLLQACNYSGSDNSSSPSPLYSNSASVSTPEEVIEAYAKGWEDRDPAAVSALFADDGLYKDPSKPLGIRGKELEEYIVYVGDTYKDHDFKKGETVKIDATHYRFDWWFESKEGIISLKGFDEVEIVEGKIKLLQGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQY1</accession>
    <name>A0A398CQY1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_03440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000021">
        <property type="protein sequence ID" value="RIE04922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04922">
        <property type="protein sequence ID" value="RIE04922"/>
        <property type="gene ID" value="D3H35_03440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="177" mass="20119" checksum="0F292955973BC144" modified="2018-12-05" version="1">MQTKAPYIISHSTFPEIEWPNPYIWLSSRGISLNLLPQNKYQLISTTWNSTSIYFYDYAGNIVEFIARHNLNYSSTSPFTSNSLLNISEIGLVVSDVPSTRELLRSRFSIDGYKNNNDCSFAAVGDEDGLFILTAHNRIWLGSNKEAKIYKTEVEIEGAVTKGELIFKDYPYKIIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR61</accession>
    <name>A0A398CR61_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_02420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the MIP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05023">
        <property type="protein sequence ID" value="RIE05023"/>
        <property type="gene ID" value="D3H35_02420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="6">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="139"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="376" mass="40694" checksum="423B963CD7224BDB" modified="2018-12-05" version="1">MLTREIVLESLQTISEPTLRRPLTELGLVRDIVVRDGSVSLTIVIHPDSEAARSAIEKEVTDSLARIESSGTPHIRYRIMTEHERSEAAIKLETAAEPTVQPSEPAEKAAPIKGHGAGLERGTLLSKESGVEFIAIASGKGGVGKSTVTVNLAVALARRGKRVGLIDADIYGFSVPDMMGIEERPEQAGEKIIPIERYGVKVMSMGFFVEGNSPVVWRGPMLGKMLRNFFAEIEWGELDYLLLDLPPGTGDVALDVHQMIPQSKEIIVTTPHATAAFVAARAGSMAIRTEHEILGVVENMSYYENKDGEKDYVFGRGGGGKLAETLNTDLLAQFALGAPNNHPSEPDYSPSVYKADSQTGREYLALADAVIRKCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR89</accession>
    <name>A0A398CR89_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome b6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_04050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04670">
        <property type="protein sequence ID" value="RIE04670"/>
        <property type="gene ID" value="D3H35_04050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00033">
        <property type="entry name" value="Cytochrome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="2">
        <location>
            <begin position="5"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="223" mass="25451" checksum="9B0985FC6D0E7DC3" modified="2018-12-05" version="1">MFKSMYNWIDERLDVTPMWRDIADHEVPEHVNPAHHFSAFVYCFGGLTFFITVIQILSGMFLTMYYVPDIINAYYSVDYLQHQVAFGAIVRGMHHWGASLVIVMMFLHTLRVFFTGSYKAPREMNWVVGMLIFFVMLGLGFTGYLLPWDNKAYFATKVGIEIAASVPWVGPYIKELMQGGTIVGAQTLTRFFAIHVFFLPGLLLALLAAHFFMIRKQGISGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRK1</accession>
    <name>A0A398CRK1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04780">
        <property type="protein sequence ID" value="RIE04780"/>
        <property type="gene ID" value="D3H35_04700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="75" mass="8530" checksum="C22736E5016253D4" modified="2018-12-05" version="1">MREWEPESWRREWTATRGPLAVFIHTPLCGTCKLARKMLDVVREVLPEAPLVAANLNAMPSLLSYFGLKAFRACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRN6</accession>
    <name>A0A398CRN6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01584">
        <property type="protein sequence ID" value="RIE01584"/>
        <property type="gene ID" value="D3H35_24880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="59" mass="6919" checksum="488B4C2CB72F24F1" modified="2018-12-05" version="1">MAANWWLALIIMVVLNGIVVWNFIVGQERVSRRAKKWFFIVANVIGLCLAVSQFFWMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRP1</accession>
    <name>A0A398CRP1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03458">
        <property type="protein sequence ID" value="RIE03458"/>
        <property type="gene ID" value="D3H35_12425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007136">
        <property type="entry name" value="DUF347"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03988">
        <property type="entry name" value="DUF347"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="299" mass="33523" checksum="8586187F9BA9A90D" modified="2018-12-05" version="1">MSNKRLIDLLFFRYTIVEEPIRYESGGGFRLKDQRSIAMNETATVMPLVRQMLNKVPEVTIFFWIIKIMATTVGETAADFLTFNLNWGLTCTTLLVAGLLCVSLVIQFRAKKYVPWIYWLTVLLISVIGTLITDNLVDNFGVPLVTTTVIFAIALLATFTVWYASEKTLSIHSIYTSKRESYYWLAILFTFALGTSAGDLLSEALDLGYWLSALLFAVLIGIVTVAYYRFKLNSVLAFWIAYILTRPLGASIGDYLSQPSDERGLGLGTTGISVIFLLTILGLVIYLTVTRRDEVNPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRP4</accession>
    <name>A0A398CRP4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PHP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_01500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05223">
        <property type="protein sequence ID" value="RIE05223"/>
        <property type="gene ID" value="D3H35_01500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="2">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="306" mass="32988" checksum="31E712E974AB9A02" modified="2018-12-05" version="1">MKTELHCHTRLSDGSFTFDEILASAIDKGISCLAITNHDTTRDLEEMRVKGLARGVEIIPGIEISAYDFARNRRVHILGYYIDPASPAIEALCAPLLEQRHQGCLSSIANLIEAGYDISLEDVLTYAEGGTGIYKQHIMHALIDKGYATAIYGDLYKQLFSRGENGEQPGIAYVKTTYVSAVDAIRVILQAGGVPVLAHPGQYRSFEALPELVKNGLRGIEVWHPLNGPTDEAMAACLAKEYGLVMTGGSDFHGIYGERETDLGSKCPGAEAILAMKAIASKPAPASMTVSKPMSDPGFREGAVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRR6</accession>
    <name>A0A398CRR6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05285">
        <property type="protein sequence ID" value="RIE05285"/>
        <property type="gene ID" value="D3H35_01840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="67" mass="7321" checksum="2DC2A793CC692EA5" modified="2018-12-05" version="1">MLLLGSRTITIEGITIFPDHADPDQFWYLPGPVQLARRDGRAAFTFIKYKPAAVTGGRRAAGSSCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRW3</accession>
    <name>A0A398CRW3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05335">
        <property type="protein sequence ID" value="RIE05335"/>
        <property type="gene ID" value="D3H35_00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="85" mass="9852" checksum="DBE5FC6AF971CB5A" modified="2018-12-05" version="1">MQKSIFNLSPLDTLMYTPEQIFTPITGNKFIAQISEPGHSGAMPAIRIDRASWNEEKEKKPMLRLAGVYFFENRKMNAHLPSRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS57</accession>
    <name>A0A398CS57_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_00445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000005">
        <property type="protein sequence ID" value="RIE05435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05435">
        <property type="protein sequence ID" value="RIE05435"/>
        <property type="gene ID" value="D3H35_00445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="79" mass="8692" checksum="F627F78FAC51782B" modified="2018-12-05" version="1">MWIIKSGVETIPVEVDEAATIDGASRSYIIFGMMSVLCRPALAAAALFIFLGAWNEFILSSIMINSPNLRPFNWLSISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS87</accession>
    <name>A0A398CS87_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04099">
        <property type="protein sequence ID" value="RIE04099"/>
        <property type="gene ID" value="D3H35_09150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="303" mass="32904" checksum="EC57B2FA053F4DE3" modified="2018-12-05" version="1">MKAVVTGGAGFIGSHLVDALIGLSFDEVHVIDDLSSGSMHIHPAAAFHRLDIRSEACREAIIGTKPDVVFHLAAQMDVSRSIADPKHDAEVNIAGTINLLEACRLASVPKFIFASTSAVYGNLQKSRMTEADPVHPISYYGLSKLSAESYIRIYSELYGLSYTILRYANVYGPRQTPKGEGGVIAVFANKIKAGDALPVHGDGEQTRDFIYVSDIVRANIAAIDEGHRETIQVGTARGTSINELIKALSEIRGEKLTAKHGPERIGDIKISCLDNRKAKKLLRWKPQTDLKEGLLATLRASLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSE8</accession>
    <name>A0A398CSE8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_03130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05130">
        <property type="protein sequence ID" value="RIE05130"/>
        <property type="gene ID" value="D3H35_03130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="82" mass="9232" checksum="9145B0B785389561" modified="2018-12-05" version="1">MLVNDTYDGLNINKSKLTAMQLMQTTYTYDSLGRLKTTVNPAAETTTYYYSNSAKNLVTNKSTFAKYGKSGSAGWKRRNFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSG8</accession>
    <name>A0A398CSG8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01894">
        <property type="protein sequence ID" value="RIE01894"/>
        <property type="gene ID" value="D3H35_14025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="93" mass="9014" checksum="435F34DB4F63D836" modified="2018-12-05" version="1">MLAFGMATGSSPFDPWEPEYQREREGASSSCQSGGYGANADGSGYDGTNRYGESGNDGSDSNGSGGDDGGSSSCSSSSCSSSSCSSSCGGGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSS8</accession>
    <name>A0A398CSS8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04309">
        <property type="protein sequence ID" value="RIE04309"/>
        <property type="gene ID" value="D3H35_06780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="221" mass="23830" checksum="F383FD8D7A4C4BBF" modified="2018-12-05" version="1">MEKRKKRWKRVLIWSIAIIVLLGATSLVVANIVVNKVISSLADGLEIDFEESADLNSTPDSQELPSPASTNTTSEGSKQTNTNPVIDSTKGTNPQSSAAADSPSKESRAPDQTDDKDKAGVYAAEVSVNKAKSIKENITLSEKASVTKILMSNLSMSDIKHIQDLASGGMTVDEKREARKILLEKLTPDEYNKIAGIAKTYGVSQGKTYAEAEKEENDASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT69</accession>
    <name>A0A398CT69_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1802 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03958">
        <property type="protein sequence ID" value="RIE03958"/>
        <property type="gene ID" value="D3H35_08335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014923">
        <property type="entry name" value="DUF1802"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008307">
        <property type="entry name" value="UCP018957"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08819">
        <property type="entry name" value="DUF1802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018957">
        <property type="entry name" value="UCP018957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="190" mass="21847" checksum="F2405CB759146F97" modified="2018-12-05" version="1">MNGQSIGLKEWAVAVKALEEGRQIIVLRKGGISEETRDFRLESPAFFLFPTFEHQRAELVKEDERAVVASTQEEAARHPGFFKLTSYAEVAEEIEVTDSATLSKLDELHIWTHDYAEERLKWKKTKPLHVLLLRVYKLEEPIELPMREEYNGCKSWTAFSDELPGRAQTPVLEDEEFAEKVSAVQEALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTY6</accession>
    <name>A0A398CTY6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_05960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04168">
        <property type="protein sequence ID" value="RIE04168"/>
        <property type="gene ID" value="D3H35_05960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="22"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="116"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="182" mass="21097" checksum="1D3C3A5BB6BFFFE6" modified="2018-12-05" version="1">MMEPALIKAAQAGDKEALVALLREIENQVYRTAYYLLNHEQDALDASQEALIRIYTKINSYEEKAQFRTWVQRIVTNICIDKFRRSKPSVSIDEHELVFESGDSVEGEVLSAYEAEEIREAIQKLPEHHRTVVVLRYLQDFSYNEIADSLHLPLNTVKSYLFRARQQLQVLLHDYQKGGVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV01</accession>
    <name>A0A398CV01_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_02920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05099">
        <property type="protein sequence ID" value="RIE05099"/>
        <property type="gene ID" value="D3H35_02920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="426"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="525" mass="59562" checksum="5F20093386CF1BF3" modified="2018-12-05" version="1">MRNVMIVDDESLVRIGLQSMIDWESRGYRITGVFKNGEEALAAATRQPFDVVLTDIRMPGMDGFELIRELRKLSPSLHVIVLSSYNDFEYTRQAIQLGVKDYISKYEMEPDELLRVLASLSFASRQEAVDKPFAVPQVPIAEEAKRLLGGREQEEGVVSALAYPNLARTLTGSGDAFRWIALLPYPREAGYSSAERKAMLLLAEEMFSRLRNPVLFGESDGCLHGGYACDSDGGFPGSREECLRMADEWTSAFSQKLNVALAAGFGTPTALSGSWTAARREAEEAVAVSLFDGGVQFREAVGERRAFTEDEWLKMYKQIKQRVRYMQFRLLSDDLTGFMDEHLDRYKPSEWIRLGVAAVSQLTDFLIERYDLETVELRERFGSLWPLDESAGAVRSAAAWRSMLHDVSVRTQEVVAHRQAKGGWVERVKIYLEAHYGEQIRLEDIAQLANFSESHFSQRFRQETGQVFSDYLTDLRIAKAVQLFRNTGLSTEEIAERVGYSNPNYFIKVFKRKTGQTVKNFKSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV29</accession>
    <name>A0A398CV29_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_19900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02884">
        <property type="protein sequence ID" value="RIE02884"/>
        <property type="gene ID" value="D3H35_19900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="227"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="2">
        <location>
            <begin position="348"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="538" mass="61301" checksum="E537037367FF25C3" modified="2018-12-05" version="1">MAKRKEDAFFGFAEERTTLQQAKTVMEAAKHHDNELLPGYAMLSDRYEKLLKEMNKVLLISDRQSNALIRMEAEMKTLLDNVGQGFLTVDGSLKVQRQTSSECQRLFDRKISGLNVTELLWPDDQSMRDKAESLLLSAMVEDSSSFLDELPAECDLGGKKLRLDYKKIQVPFTTEQVRIMIVMTDVTEQRKSQKRLEYMSSHDPLTGLWNRGHVDRWMDHNGKGSERPFSLIMADMNGLKLVNDVFGHLLGDELLLKAAQILLSVFGEKAICARWGGDEFLILLPNTDREECLGLIDRLDEACQASDGKPIKISMSVGAATSSRPQDEYAQLFLHAEKEMYKKKMLESRDSRKRLMENISDTMYEQGIEDPRHVERIATLASELAERMGIPPQSPQMNMLKMLARLHDVGKIAIPQELLANEEELTPEQWEVVRNHSEIGYRLAFSLGEPALAEAILSMQEHWDGTGYPYGLKHDQIPEFSRLLAVVDAYDVMTERKPKPNRTPLSREKALKKLLEGSGSRFDPQVVAEFVLHMERKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV51</accession>
    <name>A0A398CV51_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="2">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">raiA</name>
        <name evidence="2" type="synonym">hpf</name>
        <name evidence="4" type="ORF">D3H35_15135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03141">
        <property type="protein sequence ID" value="RIE03141"/>
        <property type="gene ID" value="D3H35_15135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="3">
        <location>
            <begin position="127"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="187" mass="21676" checksum="765A04E70C527B10" modified="2018-12-05" version="1">MKYNIRGQRMEVTDALREYVERKLSRLERYFEAPPQSDVHVTLAVTKGQHAIEVTIPLTGVMLRAEEKREDMYASVDFVVDKLERQIRKHKTKVNRKLKQTGASRSLFKEESGSGYGVATLAPEDDDEWQVIRTKRFNLKPMDVEEAILQMNMVGHNFYLFSNSDTKEVNVVYRRDDGRYGLIESVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVT3</accession>
    <name>A0A398CVT3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_08495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03987">
        <property type="protein sequence ID" value="RIE03987"/>
        <property type="gene ID" value="D3H35_08495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="611" mass="70967" checksum="FFC081FEA1946B26" modified="2018-12-05" version="1">MLMQSYVSDPFLGSRSAEQWQRIGTNRRVGALLPLASLYSRRTAGIGDLEDLKLAADWCERTGHTILQLLPINDYYNSPYSTFSLFAIDPMYMALDRLIGVPPEKLEPVIRRIQERYPTGCGYIEYDVKHEKINALYEIFREYSLGTENAAYAEFVENNVYWLDDYALYTALKFEYSQDTWENWEPSYREADPLTLREFARKHEVRIRFVQWLQWQLYEQLKAAKAYANAKGILLMGDMFYVVSRDSADVWKRRNYFRLDLVPGLPPEPAHEKGQRWGDQPVYNWDAIRESGDELLKQRLRYNANFYDIARLDTASALFRMWCIPRDEPDINQGLNGFFYPEAMSDYCEQRGKSLLSQMLSSTSMLLCAENLSPACLSFTPSVRELGIPPINFQRWDKEWDELHDFIPPDELHPVTVMVLSNHDTSLWAEWWEGEAGTIEASMFTEFCFNYGLPEAELKMRLFNDKTSVGSKLRWRDSVNSPSRVAEIVGLPEAAIGGFIHDYLNSYREKEKLWEIMKLEGPMRQRADREILKHAIRSIITSNAIWSIVSIVDYLCLLGIIDGDYGNYRLNRPGTERGRNWTWALPVSLEALMDESFCRTVRDSIEIGEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVW7</accession>
    <name>A0A398CVW7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative N-acetylmannosamine-6-phosphate 2-epimerase</fullName>
            <ecNumber evidence="6">5.1.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ManNAc-6-P epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nanE</name>
        <name evidence="7" type="ORF">D3H35_17110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23932"/>
            <dbReference type="ChEBI" id="CHEBI:57599"/>
            <dbReference type="ChEBI" id="CHEBI:57666"/>
            <dbReference type="EC" id="5.1.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the NanE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.9" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03164">
        <property type="protein sequence ID" value="RIE03164"/>
        <property type="gene ID" value="D3H35_17110"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047465">
        <property type="term" value="F:N-acylglucosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009385">
        <property type="term" value="F:N-acylmannosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006051">
        <property type="term" value="P:N-acetylmannosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04729">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01235">
        <property type="entry name" value="ManNAc6P_epimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007260">
        <property type="entry name" value="NanE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36204">
        <property type="entry name" value="PTHR36204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04131">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="224" mass="24634" checksum="91B1C83872243604" modified="2018-12-05" version="1">MLDRIREGLVVSCQALPHEPLHSPFIMSKLALAAEQGGALGIRANSRDDIIAIKQEVSLPVIGIVKRNYVDCDVFITATFKELDELLESGCEMIAMDATSRERPGGVKLSQLIAYCREMNPHVQLMADVSTVEEALEAEKLGFDCVSTTLYGYTQYTSGRKLYDEDFSFLKAVLEAVRLPVIAEGNVMTPEMYKRCLTLGAASVVVGGAITRPLEITRRFTIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVZ2</accession>
    <name>A0A398CVZ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03381">
        <property type="protein sequence ID" value="RIE03381"/>
        <property type="gene ID" value="D3H35_11935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="PTHR13355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="149" mass="17057" checksum="8F90A693214FC5C0" modified="2018-12-05" version="1">MSAYSVRIIQEDELPKLLELYKHLHDQDPELEHDDRLEALWKEILGDSGMKIIVLEQDGQLLASCVLNILKNLTRNARPYGLIENVVTHSDHRRKGFGKIVLNKAIELSGEHNCYKVMLLTGSKKEETHRFYESAGFVKGLKTGFIIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVZ6</accession>
    <name>A0A398CVZ6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04708">
        <property type="protein sequence ID" value="RIE04708"/>
        <property type="gene ID" value="D3H35_04280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="193" mass="22935" checksum="833D4F4B4E3EDF95" modified="2018-12-05" version="1">MEHAHMVRIALRTKANWSEHAQVVRIALHRKANWSEHARLARIALRTKANWFEHARMARIALRRKAKWSEHARMARIALRRKANWSELARMARIALRRKAKWLEHAHMVRIALRRKANWFEHAQVVRIALRRKANWFEHARMARIALRRMANWSEHTHMVRIALHRKANWSWSYLPPNGFGVAHLRLGPIAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW08</accession>
    <name>A0A398CW08_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04067">
        <property type="protein sequence ID" value="RIE04067"/>
        <property type="gene ID" value="D3H35_08970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="92" mass="10686" checksum="599D9E2F511A4054" modified="2018-12-05" version="1">MAGGSEQQWEEVPYIRRLAGGSEQQWEEVPYIRRMAGGSEQQWEEVPYIRRMAGGSEQQWEEVPYIRRLAGGSEQKWEEVPYIRRLAGGSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW58</accession>
    <name>A0A398CW58_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Deoxyribonuclease IV</fullName>
            <ecNumber evidence="9">3.1.21.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_04690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.2" evidence="9"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04778">
        <property type="protein sequence ID" value="RIE04778"/>
        <property type="gene ID" value="D3H35_04690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008833">
        <property type="term" value="F:deoxyribonuclease IV (phage-T4-induced) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="8">
        <location>
            <begin position="18"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="280" mass="30339" checksum="21FD2609C9E744F4" modified="2018-12-05" version="1">MRIGSHVSTRRGYREAAKAVAAMGGNAFQYFPKNPRSLQLKAFDSRDAKSCAAWCEENRIVSIAHGPYGVNPAAEGEAARLMAACTLNDLEIAEACGSLGVVVHFGVFKGSDPLQGYRNVIQWINTVTAAWQGKSKVLLENQAGDHGPSGTTPEELAQIRALCREPEKVGFCLDTCHLFASGEWAPDRWATFVERATKCGFFDGLEAVHLNDSRFPSGSRKDRHAPIGEGCIGLDGFKPMLASPEIRGIPLFLETPAGQDGTHRDQIELVRRLGKEAGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWA0</accession>
    <name>A0A398CWA0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_05005</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04828">
        <property type="protein sequence ID" value="RIE04828"/>
        <property type="gene ID" value="D3H35_05005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011620">
        <property type="entry name" value="Sig_transdc_His_kinase_LytS_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07694">
        <property type="entry name" value="5TM-5TMR_LYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="8">
        <location>
            <begin position="238"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="7">
        <location>
            <begin position="381"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="639" mass="72213" checksum="79D16DEB3E506481" modified="2018-12-05" version="1">MIMTHNWNVYGKKEDGTMFGSEIVFSLLQTIINMIVFILICNRIYPFIIHWSSYRRKVIIGFLFGIASLISLKFPIVAQKGILVNLNDVLAGMSGFLGGPIAGAITFTMAASYRAMLGGIGAVAGIGVMLVAAFIGALLHLYMRGKGFPSMRRLWMPVMFGVIIAIDSFAWTLLFPVRVRLELLHDYAIPFFTLYPLSAVVFYYLMAEEWYSLLHKRNTSLSFQTVQARLERQAAKGRPFSLVVMNIDQFKAVNEMYGFSFGDELLEEVRKRLNALLPEQGWSARINGDEYLLSLPIADRKDALQWLENAKKELTSPYTVKPDGKLVHLSFSTGLALSENNEIPVEELLRQADMALKDAKTRGLNMISPYEQRMTERLKQRTLLEEELRFALERKQLSLHFQPQFELKSGKLKGFEALLRWHHPELGAVSPDEFIPIAEETGLIVPIGQWVLRSACETMQRILPLCPSSTIGVNISALQLIPEQFPDMVLETAMLTGLPLDRLELELTESELMTSLDSAQEQLTRLSEAGVRLALDDFGVGYSSLNYLRKLPFHRVKIDRSFIQDIGTSKDDELAEAIIRLVRQLHLDVVAEGLESYDQLMRLQEWGCDIAQGYLLGRPMPESELHAFIARNTTSFSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWQ9</accession>
    <name>A0A398CWQ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03454">
        <property type="protein sequence ID" value="RIE03454"/>
        <property type="gene ID" value="D3H35_12405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="265" mass="29651" checksum="FF0C8609BD5F1B07" modified="2018-12-05" version="1">MDNNGSSNQSPGTASFDQKLEKAIEWQQKGAAGDRDAVRTAERAFKRLRTEHPDQPIVDAYFGSVLALLARDETKPKERLRLAKSALKLLDDAVARAPHDRTIRLLRGKVAYRLPEKYFSRTGTAIEDYKFLIEACQSDPSSLAPGIYQELLYELGAAYFRSDRQAEADSWWGKLMEQPDSHQYRGLIDQMKKGTNEKAGSRQSSRGSSKLQAVKTSLLGSVQQALLNERTGTTIVLLGASIISMGPRKFSKKFLSSLRKELLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXC4</accession>
    <name>A0A398CXC4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03871">
        <property type="protein sequence ID" value="RIE03871"/>
        <property type="gene ID" value="D3H35_09995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="95" mass="10910" checksum="4B5246AAECEF6A56" modified="2018-12-05" version="1">MEAYSVISFRYEVQTDGYDEGRREKSGVAPITVSRVLNNPGSVASATKKKVMKAIEELNFKPNQIARSMITRRTNTIGCFCRTLRIRIFRKCFWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXK4</accession>
    <name>A0A398CXK4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YcxB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_10485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03714">
        <property type="protein sequence ID" value="RIE03714"/>
        <property type="gene ID" value="D3H35_10485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025588">
        <property type="entry name" value="YcxB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14317">
        <property type="entry name" value="YcxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="YcxB" evidence="2">
        <location>
            <begin position="108"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="179" mass="20377" checksum="EF0F4E6F051FDCC4" modified="2018-12-05" version="1">MATRMGSDGMDDRQPYEATVNLTAEDFRKYTLYQSKAQLVGLFAFYVCLIVIAVHFGSEDKMNVLFAIPVAVLVAGGLVWYQVWRIGQRVRKIFNGDRVLQLKQKIRLTEEGIHHETGASSLDAKWDEIYKVADSGPSILIYMAKNKAFVLPKRDLADLEVVLDLLKRHVPAPRLKLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXP2</accession>
    <name>A0A398CXP2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenosylcobinamide kinase</fullName>
            <ecNumber evidence="8">2.7.1.156</ecNumber>
            <ecNumber evidence="9">2.7.7.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Adenosylcobinamide-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">D3H35_08575</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15769"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15765"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.7.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CobU/CobP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.156" evidence="8"/>
    <dbReference type="EC" id="2.7.7.62" evidence="9"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04001">
        <property type="protein sequence ID" value="RIE04001"/>
        <property type="gene ID" value="D3H35_08575"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036429">
        <property type="term" value="F:adenosylcobinamide kinase (ATP-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036428">
        <property type="term" value="F:adenosylcobinamide kinase (GTP-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008820">
        <property type="term" value="F:cobinamide phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00544">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003203">
        <property type="entry name" value="Cobinamide_kinase/P_G-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34848">
        <property type="entry name" value="PTHR34848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02283">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006135">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="16">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="32"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RIE04001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="186" mass="20549" checksum="D6D3BE959E755DB8" modified="2018-12-05" version="1">MIVLVTGGARSGKSRFAERYAASIGSRGKYIATAQIYDEEMSQRAEKHRERRNSSGFSWRTVEEPYRLGELLAESDDPIVLVDCLTLWLSNWLLLYADEERMEDKVQGKLDELTRTLAACAGTVILVTNEVGDGIVPEYALGRQFRDLSGAMNQAVAAISDQVFLVTAGIPIELKSKEFKLADGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYG5</accession>
    <name>A0A398CYG5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-layer homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_08765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04034">
        <property type="protein sequence ID" value="RIE04034"/>
        <property type="gene ID" value="D3H35_08765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="12"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="118" mass="13215" checksum="FB41450089CF6341" modified="2018-12-05" version="1">MAKYLQLDVAKPIQSRFGDAKGRWSSSYIEALDRNSLISGYPDGSFRPGNNIPRLEAVTLINRMLFRGPLTNVSPSFPDVQKSNWGFGYVEEASRSHESTRNSDGSEVFVKSIEDNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ53</accession>
    <name>A0A398CZ53_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000026">
        <property type="protein sequence ID" value="RIE04511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04511">
        <property type="protein sequence ID" value="RIE04511"/>
        <property type="gene ID" value="D3H35_05765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="106" mass="11579" checksum="AD0DB26BB1C4F997" modified="2018-12-05" version="1">MSANSEQAASGADQIADSMRELAAGADSQREGMKRGAEVTIQIRDGHLDDRRSDDFVAAVAEQATKHAQDGNETVKQAVEQMGNDRKDGRELRSGRSRIAREVQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZM8</accession>
    <name>A0A398CZM8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04661">
        <property type="protein sequence ID" value="RIE04661"/>
        <property type="gene ID" value="D3H35_04005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="121" mass="13603" checksum="13DFEF26A370600F" modified="2018-12-05" version="1">MAGEQRYAVPLISAIAAFLNGVGGTPPYIPYRRANSNWSGKVVLREKFSSEKSGYRPSLVRKNDALSEWQRIRNVFDGKKKTALTGGCTECKDWIGVERNHTVLLLYVSVYILSISVYILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0C4</accession>
    <name>A0A398D0C4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_03410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000020">
        <property type="protein sequence ID" value="RIE04931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04931">
        <property type="protein sequence ID" value="RIE04931"/>
        <property type="gene ID" value="D3H35_03410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="2">
        <location>
            <begin position="119"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="624" mass="68282" checksum="E16AF5B593B284E7" modified="2018-12-05" version="1" fragment="single">MKTMGKKAAIRYARNERGPTLGYSEASGVRLLYEDGLAFKDLNKDGKLDRYEDWRLSPEERAKDLASKMTIEQIAGLMLYSSHQAIPGNLNWFPATYGGQFFEASGAAPGDLSDQQLSFVANDHIRHILITRIQDPATAALWNNNVQAYAESLGFGIPANNSSDPRHSSDTSKEFNAGAGGAISMWPESMGLAAAFDPAVARKFGEVAAKEYRALGLATALSPQVDIATDPRWYRFGMTFGEDPQLAADMARAYIDGFQTSEGEAEIADGWGCDSVNAMVKHWPGGGSGEAGRDAHFGYGKYAVYPGGNFDEHLVPFTEGAFRLAGKTGQASAIMPYYTISVGQDSKNGENVGNSYNEYLINDLLRGRYGYDGVVCTDWGITADEGEDISRLFPGGRCWGVEEGYSVAERHYKLIMAGVDQFGGNNEIGPVIEAYNIGARKHGESFMRLRFEQSAVRLLKNMFRLGLFENPYLEADVTTATVGQAEFMEAGYEAQLRSIVMLKNEGVLPVARKKTVYIPKRSLPADTDWMGMPIPPSESYPIHLDVVKKYFAVTDRPEEADFALVCIESPRSTKGYSKADAEAGGNGYVPISLQYAPYTAEYARETSLAGDARDVLNRSYKGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D2U3</accession>
    <name>A0A398D2U3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000006">
        <property type="protein sequence ID" value="RIE05404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05404">
        <property type="protein sequence ID" value="RIE05404"/>
        <property type="gene ID" value="D3H35_00510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="108" mass="12377" checksum="3DBD70BBD05D3221" modified="2018-12-05" version="1">MELKLLQVAVDDGDLFGHSLDVLCGFLYAESTSWIVFVTVAAWPEMISDRCVTESRRSPSSREERKTRRSNVRKLLDDRRSVNRSESFFLLAATGERLPEIPSAKRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D2W2</accession>
    <name>A0A398D2W2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">secG</name>
        <name evidence="11" type="ORF">D3H35_00615</name>
        <name evidence="10" type="ORF">D3H35_29500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SecG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000006">
        <property type="protein sequence ID" value="RIE05424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00179">
        <property type="protein sequence ID" value="RIE00179"/>
        <property type="gene ID" value="D3H35_29500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05424">
        <property type="protein sequence ID" value="RIE05424"/>
        <property type="gene ID" value="D3H35_00615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34182">
        <property type="entry name" value="PTHR34182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE00179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE05424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="79" mass="8378" checksum="E568E970FC9E9097" modified="2018-12-05" version="1">MVVFLKVLLVIFSLGMITVVLLQRGKSAGLSGAITGGAEHLFGKQKARGLDLFLQRLTIGLAVGFFVLSLVVAYVVKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBD8</accession>
    <name>A0A398CBD8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_28655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00466">
        <property type="protein sequence ID" value="RIE00466"/>
        <property type="gene ID" value="D3H35_28655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="105"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="400"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="596" mass="68692" checksum="6E49DC4376443972" modified="2018-12-05" version="1">MAGDIPETGTGFEQKPPPDFTFTPAASDYPPRLIHPLVELRVDRGAFDDLERRVERNGPWDDWTMYKLAWEAEEASKVSDFHELQCLRLLPHFTPLPHQTETARKVLHDMRGRAILADEVGLGKTIEAGLVLKEYLVRGLVRKVLILVPASLVLQWVRELNGKFDIPAIAQKKEYQWASDIVVASMDTAKRDPHRSLLLDGEYDMLIVDEAHKLKNKRTGNYQFISDLRKKYCLLLTATPVQNDLSELYNLITLLKPGQLGGEGDFAANYVADRRVAKNEDKLQETLSQVMIRNRRSDGGVEFTKRFVTNVPLRLSPEEMALYDGVTNYVRQHAQTERGDLSSMLSLVTLQREVCSSRDAVFLTLINLFKKTEEDSPLRARIWELVELIKNIKANTKAQKTMELIEQIGDKTIVFTEYRQTQEYLLRFFKERGLQAVTYRGGMNRGKKDWMMDLFRRRAQVMIATEAGGEGINLQFCHHIINFDLPWNPMRVEQRIGRVHRLGQKEDVRIFNLCTSGTIEEHIVHLLHEKINMFEMVIGELDEIVERMEKEEALEKRLAKMVLESADENDLRKKIDGLGDKLLETRNQLHQETNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBS9</accession>
    <name>A0A398CBS9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_29795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00230">
        <property type="protein sequence ID" value="RIE00230"/>
        <property type="gene ID" value="D3H35_29795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="66" mass="7176" checksum="1709F2B54DA05AC7" modified="2018-12-05" version="1">MEAGIVKWFNADKGFGFIEVDGGSDVFVHFSAIVGDGYKSLDEGQRVEFNVVQGNRGPQAENVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CC62</accession>
    <name>A0A398CC62_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_28470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00360">
        <property type="protein sequence ID" value="RIE00360"/>
        <property type="gene ID" value="D3H35_28470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="77"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="265" mass="29307" checksum="D78F1798D2832365" modified="2018-12-05" version="1">MEVPSVIDTSKKYTVPSLEKALAIIETLAELDHPLGVSELCKLVGVPKTSAFFILNTLDQHRYIHKTEDGKYTLGNRFINLGQSILSKMDIRQQAKPFMEELSRETRFTVHLAILDQGEALYLEKVESSTFVKFSTYIGQRWPLHISGVGKALASHLSEEELDRIIEEKGLPAKTDNTVSSAREFKAILATAREQGFAVEDEEGEVGIRCIGSSIFGHNGQQLGAISITALRSELPIQDIQNVGEKVKEAALKISKHLGYQPSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CED7</accession>
    <name>A0A398CED7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_24600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01536">
        <property type="protein sequence ID" value="RIE01536"/>
        <property type="gene ID" value="D3H35_24600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="225" mass="24273" checksum="A4A459C8E6F1F023" modified="2018-12-05" version="1">MTTGLHMSNVTKYYSEGSNKIAALDQVSITISPGELVAVVGPSGSGKSTFLSVAGALLKASQGEVNISGQELSELSDRELSTIRLNEIGFIMQSSNLVPYLNVLDQLLIVKRMSGKVKSADKEVAIRLLEELGLGAKLKSFPEALSGGEKQRTAIARALINDPKVILADEPTASLDTKRAHEVVGLIAKEVKSRKKAAIMVTHDERMLEYCDKVYRMEDGKLTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEF2</accession>
    <name>A0A398CEF2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF975 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_21920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01083">
        <property type="protein sequence ID" value="RIE01083"/>
        <property type="gene ID" value="D3H35_21920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010380">
        <property type="entry name" value="DUF975"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40076">
        <property type="entry name" value="PTHR40076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06161">
        <property type="entry name" value="DUF975"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="209" mass="23311" checksum="C31E11EED3D07057" modified="2018-12-05" version="1">MLPTSAEIRARARQSLRGNWGLAIGTLVLFYIASFALGLFNLIPFAGWIVGFVLAGPLALGLNMFFVKLARLNSPSVGDAFEGFGRFVPAFVLYLLVGIFTFLWSLLFIIPGIIASFRYSQAFYIMQDNPNMDALEAINRSKQMMVGHKWRLFVLYLSFIGWWILGALTFGIGYLWIAPYVLTSAAHFYDDLKDRVAVPPPPPPGFTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEG6</accession>
    <name>A0A398CEG6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_24780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01566">
        <property type="protein sequence ID" value="RIE01566"/>
        <property type="gene ID" value="D3H35_24780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="168" mass="19366" checksum="11F69BC5D56B55D1" modified="2018-12-05" version="1">MKEGQTFTIKQTAKQTGISEDTIRYYEKIALLPRAERKDNGHRIYRQEDIETIRLITCMKKTGMPLEEMRPFLAVSTDADPAEYPELVVLLRSHRENIVSQISSLQQVVDFIDMKLEQGRYRRDCSDEIQDDVSENRMEEPKPKSVSTDQMSYFSVPAGMGKSPTSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEH3</accession>
    <name>A0A398CEH3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4395 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_29920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00252">
        <property type="protein sequence ID" value="RIE00252"/>
        <property type="gene ID" value="D3H35_29920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025508">
        <property type="entry name" value="DUF4395"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016942">
        <property type="entry name" value="UCP030042"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14340">
        <property type="entry name" value="DUF4395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030042">
        <property type="entry name" value="UCP030042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4395" evidence="2">
        <location>
            <begin position="6"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="137" mass="15202" checksum="5FEFABB5459A8A8F" modified="2018-12-05" version="1">MNIPLAYVKANQTGIVLLVLISLLFQPWLLAALWLVQVVGLATNGRWNLFVRIAKPFLQTSNRPTQAAELTRFNNLLAVLFLTVSLLFLLVGWTAAGYSAALMLLAAASAALLGYCVGCTIYFQYKQFRHRVSRKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEU4</accession>
    <name>A0A398CEU4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA repair protein RadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_24935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01696">
        <property type="protein sequence ID" value="RIE01696"/>
        <property type="gene ID" value="D3H35_24935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="30"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="164" mass="18439" checksum="D9FF6E940C13F412" modified="2018-12-05" version="1">MLKINHCIPKRVDVVKVKLVREKSFLSLQNVGSPEEAHQLLRKFIQFELDREYFLLLCLDTKNRPTTIQVIAVGTLDSVLIHPREVYKTAILANAASIICAHCHPSGDPEPSPEDLKITRRLMRTGTIIGISLLDHLILGTDNNYISFKETGLMELQNPPNSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEY3</accession>
    <name>A0A398CEY3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_28965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00442">
        <property type="protein sequence ID" value="RIE00442"/>
        <property type="gene ID" value="D3H35_28965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="119" mass="13365" checksum="FAF1E3A9E75569B6" modified="2018-12-05" version="1">MLDAASLKPSDLEIVYLEPNEAQPAFDGGSVDAWAIWDPLLTSEIQQKEARVLIDNKQVNAISPIFALARSEFAEKHPNWSSLSCRRTRRAGSGTTIIMTKLPTFWPHSKKWKSRLSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF07</accession>
    <name>A0A398CF07_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycerate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_23305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01313">
        <property type="protein sequence ID" value="RIE01313"/>
        <property type="gene ID" value="D3H35_23305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="PTHR21599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006078">
        <property type="entry name" value="GlxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="SSF110738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00045">
        <property type="entry name" value="TIGR00045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="382" mass="39932" checksum="CC34213DEEB348FE" modified="2018-12-05" version="1">MKIVVAPDKFKGSLTAKQVAEAIRRGLLDAHPNWNVRTFPMADGGDGTMECLVDATGGHYGSTVAKDPIGRSRNVEYGILGDGLTCVAELASSSGLTLLAPHERDPLRASTFGFGQLIRAGLDAGARRFILCLGGSATNDGGAGMLQALGFGLLGDKGLPIGLGGEELRGLRILTRDGADPRLTQCEWIAACDVNNPLLGLHGASAVFGPQKGATAEMVGRLDEALSNWADILTATTGIRVHDMPGAGAAGGVAAALAAALGARLAPGVRICLEASGIERELAGADLVITGEGRIDSQTLSGKTPLGVAQAARNFGVPVLLVGGDIADDVTLEHWQQYGVRRIIGLREKEMSMLEAISQASRLLENRMFCFFRDESEKFFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFC8</accession>
    <name>A0A398CFC8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_14035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01896">
        <property type="protein sequence ID" value="RIE01896"/>
        <property type="gene ID" value="D3H35_14035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="41"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="127"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="203" mass="23189" checksum="E15BF326F990D00D" modified="2018-12-05" version="1">MTANKEASSSPNVAVSANAPDSETLARMALSGDDEAFFRLVTDDRERLLRIAYAYMKNEHDALEAIQEATCRAYAKLRKLKEPSLFLTWYTRILINCCIDEQKRKRRMLPMLRLPEGAAIDRLPDERLRLDAAIAKLAPHYRHIIILKYYEDMTLTEIARLLEKPDGTVKTWLNKALKKLRADLGEGGGGFHDRWGEDGTLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFW9</accession>
    <name>A0A398CFW9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_25045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01613">
        <property type="protein sequence ID" value="RIE01613"/>
        <property type="gene ID" value="D3H35_25045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="178"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="277" mass="30783" checksum="23231005B203A1D5" modified="2018-12-05" version="1">MQAATGLTLTGGLGVRIEDVLQLDASYQSALAASYRRFRSGGNTLYEFGDGPESAVADTVDDLLQIVKRIVNDPFADKRLRGGPLLAELLSEPDDAPANYVYSFGAFLLRELERGSEERRPEQWKRAWQTLDGLLPSDAPTQTLDSANAAYQAALDTLQTPTAAADKSADANEPRIVDDIRRFIEENYAKPISLSLLSDTFQLSQQHISTAFHKHVGMPYIKYMTRVRMENAARLLSEQPDAKIFEIAESTGYANVKHFSYVFKKHFGVTPGEYPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG21</accession>
    <name>A0A398CG21_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02156">
        <property type="protein sequence ID" value="RIE02156"/>
        <property type="gene ID" value="D3H35_15520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="73" mass="8326" checksum="B6958511354662E7" modified="2018-12-05" version="1">MARNSNRRLLTEADFVEALERGARLRVFQDDHIVSTGGVIVRFDDSTVVVQSGVGDIDYLSRTDCEFFEMRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGA8</accession>
    <name>A0A398CGA8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CpaF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_25355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00982">
        <property type="protein sequence ID" value="RIE00982"/>
        <property type="gene ID" value="D3H35_25355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="173"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="392" mass="43831" checksum="489301888E8E270C" modified="2018-12-05" version="1">MEWDDQVSDDDLRTLIESELFRREKHRRLTAAERHSAVSRVFHSFRGLDALQPLLSDPSITEIMINGHRDIYIEREGEVVPVPIEFESRERLEDLIQFMVGGVNRIVNEASPIVDARLPDGSRVHVVLPPVALNGPTVTIRRFPPKPLDMKELVARGSVSEEAARLLRRLVRAKYNLFISGGTGSGKTTFLNALAEWIPEDERIVTIEDSAELRLRGIPNWVPLETRNANSEGKGRIGIRELIRASLRMRPNRIIVGEVRGEEALEMLQAMNTGHDGSLSTAHSNGTKDMVSRLEAMVLSGADLPVSVVRKQISSAIDIFIHLSRFRDRSRRVAEISEVIGIGQNGEVELASLFRFEEEGERIGESVGKLVQVGRLRNESKLRFAGEGTDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGL9</accession>
    <name>A0A398CGL9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF305 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01605">
        <property type="protein sequence ID" value="RIE01605"/>
        <property type="gene ID" value="D3H35_25000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF305" evidence="1">
        <location>
            <begin position="67"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="123" mass="14160" checksum="CBF3FE7746953CB0" modified="2018-12-05" version="1">MIASLWYYQGRSRKGIFDHRAIKPENVFNQCANDFERSAYRRGFEPIAQTMFFEMGTAPVTNGVNANFVREMIPHHEGAVRMSNNVLQFNICPGLKLILYAIITTQCEGIRQLKHLLNHLDNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH14</accession>
    <name>A0A398CH14_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HEAT repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02496">
        <property type="protein sequence ID" value="RIE02496"/>
        <property type="gene ID" value="D3H35_17545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="556" mass="61330" checksum="8AB22AD8C7C04519" modified="2018-12-05" version="1">MSMDALIELRHEVRRLFIAGGKLAPGDLKLTKLVPSLRQIGETAPVFARVAQSVERAIGPAEDDGASRLLELAMLLNSISYTQGRTDIGDGEIVPLQGGHDFSYANIGYRKIKPVLDALTQKGPGRLEVLQTAYQEGVFRDFRLLIPAVSALDESYPEIPELLIHAIIPSYGSYALPVLHAKLELDGGKGDSRRLQMIHRLSGYAEIDLYARAAEEGAFEVRLAAIHALGDYSDQEERLLGLAGDRRKEIRRAALASLSRLDTPKAAAKIFEALASKDREIAIEPARQSRDVRLVARIIELADSLKADIKDGRKDEETVGRLQSALEALEGRQTSEMFGLLKSLLNDPAFAIRETSGIQERAVQQLVRLNDPEARKFAVSLKDSHNGNFLSYSFGAALRSLPPEEAFDSFSGFFEQGRKGVVRDLLRVFHDFVSSEDEETAASGSGEKVDSRWIGLFVKTDHINSVSRLIRPQDSNAAAYLADKCKAEPDFTDHDTVRALLALYRIGHKDTPELLMHVLYSGVHGNIYYLNDDQMNALMLLPGAYAEPLPGSRQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH25</accession>
    <name>A0A398CH25_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyphosphate polymerase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01765">
        <property type="protein sequence ID" value="RIE01765"/>
        <property type="gene ID" value="D3H35_13255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VTC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="246" mass="29767" checksum="FC5202716EE3C741" modified="2018-12-05" version="1">MAIEVFNRYENKYLMDSKAFYALYNRLLEYMVLDEYNKDDKFYSISNIYYDTEQDSLIRNSLAKPKYREKLRIRAYGIPERNAKVYLELKKKVFGLVNKRRTALKLNEAYEFVRTGTAPEPKEYMNRQVIQEIDYFLQRYELQPKVYLAYDRIAMFCKNNRDLRITFDTNIRSRRHDVRLESGDYGEQLMERGQWLMEVKAEKTIPVWLSHLLSELRMFRTSFSKYGNEYKKMLTNDKLAKESILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH30</accession>
    <name>A0A398CH30_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vitamin B12-dependent ribonucleotide reductase</fullName>
            <ecNumber evidence="7">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_28660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the ribonucleoside diphosphate reductase class-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00389">
        <property type="protein sequence ID" value="RIE00389"/>
        <property type="gene ID" value="D3H35_28660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02888">
        <property type="entry name" value="RNR_II_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013344">
        <property type="entry name" value="RNR_NrdJ/NrdZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02504">
        <property type="entry name" value="NrdJ_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="6 7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5 7" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIBORED_LARGE" evidence="9">
        <location>
            <begin position="151"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="645"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE00389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="877" mass="96515" checksum="2905FB9C00169466" modified="2018-12-05" version="1">MFRLDTKTVQGQRLTGLSEKIFLDRYAWKNADTDATKVGDVVLVLTKDDPKFPAKEVGEVVKREGRHVTVKTRSGELVESTVEKLTLTIEKTPEEMWTRLAGAMASVEASPEKQAEWSEKFRWLLDDWKLVPGGRIAAGAGASEELTLFNCYVIPSPHDSRGGIMETLSEMTEIMSRGGGVGINLSSLRPRRSIVRGVNGSSSGAVSWGGLFSYTTGLIEQGGSRRGALMLMINDWHPDVVDFITVKQTMGQVTNANLSVCVSNGFMKAVKEDLDWELVFPDTSDPEYNELWDGDLDKWKKLGKNVIPYRTVRAREVWHTIIESAWKSAEPGVVFMEYYNQMSNSWYFNPIICTNPCGEQGLPGWGVCNLSAINLSRFYDADRHDVAWEELGKVVRYSTRFLDNVIDKTPYHFPENEANQKKERRVGLGTMGLAELMIRLEIRYGSPESMEFLDKLYGFMAHEAYLASTEIAAEKGSFPAFDANKFLQSGFMKNMTKAFPEVGEAVRKRGMRNVTVITQAPTGSTGTMVGTSTGIEPYFAFEYYRQSRLGFDKQLVPIAQEWQDAHPGEELPEWFVTSMSLSAMDHIRAQAAIQRWVDSSISKTANCPADFTVEETKELYEKAFELGCKGVTIYRDGSRDVQVLSTAKDEKKEETAKGESSKDEAVKAELATEAVPAAGESAVATLDRTLNASVTPQQAQVFDKQYRSRPKVLRGATYKFNTPFGMAYITVNDIDGTPGEIFLNVGKAGSDVFAMAEALGRVCSLFLRYGDHGNKVQLLIKHLKGIGGSGAVGFGPNRVESIADAVAQALEQHAGIGDAPHEHAAAVESATPLISATIDKLSKPYTSTDLCPSCGSASLINVEGCKTCSSCGYSKCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH56</accession>
    <name>A0A398CH56_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RHS repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02546">
        <property type="protein sequence ID" value="RIE02546"/>
        <property type="gene ID" value="D3H35_17810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="701" mass="76957" checksum="772D845C520DF481" modified="2018-12-05" version="1">MQTTNRYGNAVAYTYATGSTTIKDPAGRTTIKWFDASGFVTKSQDPEGRIATAEYYLDTAGVNKYGEEKIIVDRYGNKTEYVRDTTNGNILTQINPDSSKYEYAYDTKNNLISEKDETGRATYYVYDAAMTKLLQKAQPLNGTDVYDAKADPDRFAITTYDYYTDAESSQLGYKAKGLLRSETDPEGNVTAYEYDAQGNKTAVTDPDGNTTSFEYNGLGWLTAKVSPTGYRTEFAYDKAGRLFRTVLDGGETSFTEYDALGRPVQKVTPNVYKSSEDGLNDTPAAYTYKNDNVGERYTYWPNGMLQTTTDALGFVTSYTYDVYGNLSSESKPNGAVYLYQYDVMNRLKKTLFKRSASDAPVTLETVAYGVLANGSTTRTVTTYFSDSDTASTVYTIDKNGREVGKRLPDGSSTSTAYDVNGLVQSVKDARGNSTYYRYDGLGRLMATWSPLDNGKYSYKGTVYDKAGRAIASRTGKDAVSLYTIPADDRVMWAKSTYTASGQVAGTTDSAGGKTQLTYDEEGALIRQEVSTAKDEVALTEFEYNHLGKPVVQKQHVRNGDLDGNASDDDGDTAILTTYEYDAEGQLKKQTAPDGVVTSFSYDALGHLLSTRTEGLDENGNPAELVTATTYDWAGQPLTQVDAKGNVTSFEYDRRGFLIAQTDALGGIAQYQYDRGGRKTKAASRSKSRTTSPPGRNIRTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHG0</accession>
    <name>A0A398CHG0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02646">
        <property type="protein sequence ID" value="RIE02646"/>
        <property type="gene ID" value="D3H35_18380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="297" mass="34025" checksum="363B9F5DF8B32C26" modified="2018-12-05" version="1">MTEYGSSLLSAMSWFIQLAFAFVGFAAVLKLGFVRRYRWQVSLKSWKKGGAPPWFLKLWRTDRDSPALRERQLLFARCGIRLSPAAYLATQRMAITLLPAAGLSVYSLGRIGWITPLASWNMMIGCSLLIAAAAFDRTALNGFQRYRTDRIRRELVIVGSQLLYYTGSRLHLHGKLMRCLPLTRTIRGETGLLLNEWYYDADAALRRFKDRLGTEEAYAFSECLRTLKTHESEEVYGLLRDIVKDYKAKIEMAKASRKETSSYLLFVLAGIPILYTFQLFLFPWVQEAAKLFDSLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHH9</accession>
    <name>A0A398CHH9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_28580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00378">
        <property type="protein sequence ID" value="RIE00378"/>
        <property type="gene ID" value="D3H35_28580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="426"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="530" mass="59601" checksum="5D21F6420D328D9B" modified="2018-12-05" version="1">MRQVMIVDDERWIRRGLIQSIPWDELGLELAGEAEDGKDAYDMALEKKPDLMFLDMRMPGLDGKQLLALLRRDLPELLTIVVSGYSDFEYTKEAILHNAFDYLLKPVKKEELASVLEKALVRLNEQESLKRKTAVDNRKNGLWSALFQRERSNDAEREAADDGAAERWKPGEEAVVMVAQPDRFCDRYETQLLTDELQSKLMRDKAFYMGGAWDFALTAAPGDAGEIVLSIRSGQPELREHRSLVADVQALLKQSGNSSYSIGISDPVGHVSELPQAYKQAKTSLSAKKLGIACAILYPKRETASGAGQYPRELETKLLLTLQMGSEEAAKSEFGRFYAAVAEDGMTVDDLQRSASLLVHAIEKQLHASQASLEEISGTGPLGYAEIIKARNDAASIRTLFECRIIPAASAYYGATVANQGEKIVREIQKLIEIHYAQPLSLHQIAESRFVNPDYLSRLFKKTTGRNFVDYLADFRIAKSIEFLKDSKHKNYEIAKKVGYEDYRYFSQIFKKKTGMTIGEFRSSRPPTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHV6</accession>
    <name>A0A398CHV6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TlyA family RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_26345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TlyA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00719">
        <property type="protein sequence ID" value="RIE00719"/>
        <property type="gene ID" value="D3H35_26345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005578">
        <property type="entry name" value="TlyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00478">
        <property type="entry name" value="tly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S4" evidence="2">
        <location>
            <begin position="7"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="278" mass="29928" checksum="978CBD3ED03F0C8A" modified="2018-12-05" version="1">MTAAAKERLDVLLVEQGYFESREKAKATIMAGLVFVGTERVDKAGTKVPRDSAITVKGAPHPYVSRGGLKLEKAIKSFGIELDGAIMLDIGASTGGFTDCALQNGASFVYAIDVGYNQLDWSLRQDERVLVMERTNFRHMTPEQLPGPRPGFASIDVSFISLKLILPALTGLLEPNGRVVALIKPQFEAGREQVGKSGVVRDSSVHASVLREVLDAAEGLGFELLGLTYSPITGGEGNIEFLAYWEFPPARTDGDARPPVSHAQLIRDVVGQSAGAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHW4</accession>
    <name>A0A398CHW4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_19650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02846">
        <property type="protein sequence ID" value="RIE02846"/>
        <property type="gene ID" value="D3H35_19650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="261" mass="27843" checksum="312ACA70B15070F8" modified="2018-12-05" version="1">MGAVDNKGAAALAIRGLTGGYSVRKPVLHQVSFEVFPGQLIGLIGLNGAGKSTAIKHILGLMIPHEGEVRVNGVLLEEDRELYRSSCAYVPEQPNLFPHLTVGEHLQWTAMAYGMERSEAETKIRELAEKFRMTEAMGSLPDTLSKGMKQKVMLMNALLASPSLLIIDEPFLGLDPLATRGLIEALAAAQAAGCAILLSSHILPALERRADGLIVLHRGKVIAHGTPSDVKRQAGCTDAESTLDDAFELLVTAAEGGAFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIF2</accession>
    <name>A0A398CIF2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_13655</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01832">
        <property type="protein sequence ID" value="RIE01832"/>
        <property type="gene ID" value="D3H35_13655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="9">
        <location>
            <begin position="209"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE01832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="452" mass="49329" checksum="2471B35E6789F342" modified="2018-12-05" version="1">MITATRASLYVQQVYEGVLKRNPNENEFHQAVYEILTSLEPVFEQHPEFIERGILETIVEPERMVSFRVPWVDDQGKTQVNRGFRVQFNSAIGPYKGGLRFHPSVNASIIKFLGFEQIFKNSLTGLPIGGGKGGSDFDPKGKSDNEIMRFCQSFMTELYRYVGQDTDVPAGDIGVGAREIGYMFGQYKRIRGGNEPGVLTGKGLDYGGSLTRKEATGYGCVYFVDEMLKTVGDSFQGKTVVVSGSGNVSIYAIEKAHQLGAKVVACSDSGGYIYDPNGINLDTVKQLKEVERKRISEYVKIHAGAEFHADYQNIWSIPCDIALPCATQNEIDEQSAKTLVANGVKAIGEGANMPSTLEAINVFLDNKVLFGPAKAANAGGVAVSALEMSQNSMRYSWTFEEVDTKLKQIMTSIHANSAKAAEQFGHPGNLVVGSNIAGFLKVARIMMAHGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIF3</accession>
    <name>A0A398CIF3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_21005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03066">
        <property type="protein sequence ID" value="RIE03066"/>
        <property type="gene ID" value="D3H35_21005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="109"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="245" mass="26780" checksum="FC1B3644F9492420" modified="2018-12-05" version="1">MIDIHSEEAAIRELENEAMERLKAVVQRYCLSLSGTAWDADDLAQEVWLKVLGSETGLSHANPEALLLRIAKNAWIDRSRREWRRVKIQNSDAPAAALSDSAIFEVEAAFQALIKHLSSLQRSVFLLRDVFGFSIAETALRLQLSEGAVKAAHHRARASLGSVRKELSGNALPLPEDEGMRAILRALATAYRDGDVAKVVQLAQLDTLEPAVAMVLFQNGLLRKASSHPQPALGKSGAPLMRMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ51</accession>
    <name>A0A398CJ51_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-sulfur cluster insertion protein ErpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">erpA</name>
        <name evidence="3" type="ORF">D3H35_19235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family. Ycf83 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02773">
        <property type="protein sequence ID" value="RIE02773"/>
        <property type="gene ID" value="D3H35_19235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031108">
        <property type="entry name" value="ISCA_plant_cyanobact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47265">
        <property type="entry name" value="PTHR47265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="2">
        <location>
            <begin position="2"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="119" mass="12699" checksum="28D53000281EE6F8" modified="2018-12-05" version="1">MVNISESAGDKIQEMLTEQEIPNLFLRIGVKEGGCSGFSYGMGFDDEQHEDDQVLEIRGLKVVVDAESSKYLRGVEIDWKDSAMGGGFTINNPNASATCGCGSSFRTATEAGNPAAEPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJG3</accession>
    <name>A0A398CJG3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02460">
        <property type="protein sequence ID" value="RIE02460"/>
        <property type="gene ID" value="D3H35_17325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="177"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="335" mass="38164" checksum="A9DBEE8C64CD6002" modified="2018-12-05" version="1">MHVLGRAKAPLRELSFQLRQVELVTCTPECVYAKKPADVHTLLVCGNGKGKLYKDDEVLLFSRASAFLLPPQASYQFKSSDDQPVECCKITFSVTRMDPSGSPKLFRDELFPHRNELRVYPSSQLMEMAEAIYRGEEQQEGMAYFEQNMDFLKLMNFVLRQHLPSDEDESSAVVAVERTVRYLQLHYFDKITVGQLERLSGLPSGQYSAVFKELTGKKPLDYLTELRIRHSQSLLLETNESLRHIAERVGFTDEYYFNRRFRQTTGMSPRQYAASMKGRVRVRDWAGHDVIIPAKPSRIMFYGETIEDLLALGIQPVGGGCTVETAGSILKTPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJG6</accession>
    <name>A0A398CJG6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase</fullName>
            <ecNumber evidence="5">5.3.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">5-keto-4-deoxyuronate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">DKI isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kduI</name>
        <name evidence="6" type="ORF">D3H35_17525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate</text>
            <dbReference type="Rhea" id="RHEA:23896"/>
            <dbReference type="ChEBI" id="CHEBI:17117"/>
            <dbReference type="ChEBI" id="CHEBI:29071"/>
            <dbReference type="EC" id="5.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the KduI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02495">
        <property type="protein sequence ID" value="RIE02495"/>
        <property type="gene ID" value="D3H35_17525"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008697">
        <property type="term" value="F:4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00687">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007045">
        <property type="entry name" value="KduI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021120">
        <property type="entry name" value="KduI/IolB_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027449">
        <property type="entry name" value="KduI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38461">
        <property type="entry name" value="PTHR38461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04962">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006625">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="277" mass="30929" checksum="916BE7C456DA5D60" modified="2018-12-05" version="1">MEIRHSTNPSDAKKYDTAQLRHHYLIEELFVDGQIKMVYSHEDRLIVGGAKPTDEALALEAQETLKTDFFLERREIGFFNIGSSIAVITVDGEAYELGKLDTLYVGKGAKDVRLASKDAAAPAKIYFTSALAHSTFPTRKVSVEEANTLHLGSLESSNERTIHQIIHENGVQSCQLMLGVTLFKPGSVWNTMPMHVHDRRMEAYLYFNLGEDARVFHMMGEPDETRHIVVANEQAVISPAWSVHSGAGTSSYAFVWAMAGENYTFKDMDAVPMSTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK89</accession>
    <name>A0A398CK89_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tartronate semialdehyde reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_10555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03726">
        <property type="protein sequence ID" value="RIE03726"/>
        <property type="gene ID" value="D3H35_10555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="4">
        <location>
            <begin position="165"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="PilZ" evidence="3">
        <location>
            <begin position="322"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="433" mass="45814" checksum="FA17AE1734DC6E0F" modified="2018-12-05" version="1">MNTIGFIGLGVMGGPMAANLLRKGYAVTVYNRTPGRTEELEKLGADVAASIPETVRSADVVISMISNDQAIEQIYYGENGVLAALKPGTTVIDSSTISPALARRLANDVAAQFCDFMDAPVTGSKPAAIEGTLLFMVGGSKTTVAAHRELLLAMGKEVIHVGDSGSGAVAKVAHNTIVGINAAGLIEGMAIAAKGGLDASSFLRIVQSGGAASKQADLKGNKIIDHDFSVQFSLDLMLKDLKLSAALTDGLGVSTPMLEAAKSLFQIGQASGYGELDLAALARVYEEWIGMRIGNVAAAPSSSAEEELAAASSAAEYISEKERRKKARLSLEIPVMLSIYQWLQEGSFSGQSLPGYIRDVSEDGLQISSASPLEKDMFVIVHLPPEAGLPPMTARIIRIEKENGMFKYGCLLTALSLYQRIQLKEYIDSKLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKG8</accession>
    <name>A0A398CKG8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_09640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03806">
        <property type="protein sequence ID" value="RIE03806"/>
        <property type="gene ID" value="D3H35_09640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="261" mass="28415" checksum="454634A549004DF5" modified="2018-12-05" version="1">MRGPVRRSIEAGLGECLMKTRERKIKLAGRLNKWLRFIQYWSAQKNGGNVDPSVTIEVGSRVSPGAAIGRYTYVGHNTHIAAGQIGAFCSISWNVTIGADEHPITGVSKHPFWYSPSHPSFAADELRWTQIKEEPVIGNDVWIGAGATILRGAVIEDGAVVAAGAVVTGRVPAYAVVGGIPAKIIRTLFDEETAQAIRRTKWWEWDAGRLREAAPYFSDPAQFIRRFAVAGADRTEEPSYAGQRQAESRSAASPVSAILDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKI1</accession>
    <name>A0A398CKI1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NAD(P)-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_29580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00191">
        <property type="protein sequence ID" value="RIE00191"/>
        <property type="gene ID" value="D3H35_29580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="7">
        <location>
            <begin position="18"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="357" mass="38014" checksum="71AC4A2EC9FB9888" modified="2018-12-05" version="1">MSQTIKLPETMKAAVMTGTRQIRMEDHPIPKPRANEALIKVMAVGVCGSDIHYYEHGRIGRYVVEGPFVLGHECAGEVVAIGENVTRVAVGDRVAVEPGVTCGTCSACKAGRYNLCPDVQFLATPPVDGAFVQYMTHREDFLFEIPTTMSYETAALVEPFSVGIHAARRAGVQPGSAVVIMGMGPVGLMAVIAVKAFGAGTIIVADLEEKRLNAARQLGATHAIQVNRDDAAAIIEELTGGIGADAAFETAGNDRALLSALKSLRRGGALAIVGLPPQGDIPLPIPFIVDNELDIFGVFRYANTYPDGIRFLSSGMTDLDAIITDRFPLAETWAAMERALTSKSDTLKVIVYPNGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL42</accession>
    <name>A0A398CL42_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_14320</name>
        <name evidence="6" type="ORF">D3H35_14405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01945">
        <property type="protein sequence ID" value="RIE01945"/>
        <property type="gene ID" value="D3H35_14320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01959">
        <property type="protein sequence ID" value="RIE01959"/>
        <property type="gene ID" value="D3H35_14405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19157">
        <property type="entry name" value="AKR_AKR5G1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044500">
        <property type="entry name" value="AKR5G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="20"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="275" mass="31403" checksum="ED90E6B10334A427" modified="2018-12-05" version="1">MALSIGSTVELLNGVLMPRLGLGVWRTPEGEQTEEAVTAALNAGYRSIDTASLYENEGGVGRAIRESGIAREEIFVTTKVWNNEQGYDNTLNAFRNSLERLQMDYVDLYLVHWPVAGKYLETYKAIEHLYEQGKVRAIGVSNFLIHHLEDLMGSCRIKPMVNQVEFHPLLTSKKLLMFCRKEGIQLESWRPLMQGRLDIPLIRELASKYGKTPAQIVLRWHLQQGVVTIPKSVRKERIEENADLYDFELAPEDIVRIDGLNEDRRFGADPDRVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL96</accession>
    <name>A0A398CL96_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00411">
        <property type="protein sequence ID" value="RIE00411"/>
        <property type="gene ID" value="D3H35_28785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="33"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="270" mass="30066" checksum="BF2C85B0BC727EAD" modified="2018-12-05" version="1">MNSKGYSSAHYGFLHEYERLNGTSIPMEVLVRKIAESGVRAFESDPTDELVSLAKEHGLHISAAYIGLNLHETADSLQLDNKLLPLLERMARHEVPTLLLNADPKGGWSSPEVKTEDELKQQGENIARVDQIAKAHGIECCFHNHGATKPLAEGDLRSVTEFDGKEVKLCIDTGWAHVAGYDPIEWIRTYSDRVSAVHLRNQRGPVPSVQFDEGELNAAQLLSALREIGYSGWLTFELYHMAETMSALSVAEATKRSAAFVENFYRNHHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLF2</accession>
    <name>A0A398CLF2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Penicillin-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_21155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transpeptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03090">
        <property type="protein sequence ID" value="RIE03090"/>
        <property type="gene ID" value="D3H35_21155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_dimer" evidence="4">
        <location>
            <begin position="62"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="275"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="609" mass="65266" checksum="5F4EFAFEA3FB06BE" modified="2018-12-05" version="1">MSNRFAYRAFQMLLILVCLFAIAALRLAWVQLGSGRGRAEPSASIARQAVLEHSDELVIDTGRGRFLDRNGYLLTDRTVNGLVAFPTGGMPRGSEASINQLAAALGTTGESLSNWLDSLKEPAMWRAHKSPVAANLTDKQASAVASAGLNGVFALPYRNRYPDGSEPLHAIGYVSQHPERLSRLYASQLARNQIKETDGIGGSGLEKSLDRLIRGIGPTEAVRLTDAQRRPLSGLGVRLTTPDNAHFPLQVHTTLDHGMQEAVAALMEKAGVKQGAAVVLDVRQADILTMVSLPKLNPYRIGAEGTDERNHALTAFPPGSVFKTVTLAAALDSGTAKLDDLFRCDGEFDRYGLKCWLQGGHGVLTLAEAYAQSCNVAFAMLAEHLDPAWLQITADRLGLGRQIGWNSEAFKDGKPLRLLGEEESGKIFSSRKAAEDGGVRTGTGIGQRDVRLTPLQAANLVVTLLHGGKVASPRIVSEIRYGDGALFAALPPQSAPSSYGAIRPETAAAVLKQMRAVVTDGTAESALGNAKWPLAGKSGTAELAGKLKARNDHWFIGYGPAEGTPRYAVAVLIENQPAGLRNRASALFGDIMDSLRDRDEQAEARTERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLL8</accession>
    <name>A0A398CLL8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YlxR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03325">
        <property type="protein sequence ID" value="RIE03325"/>
        <property type="gene ID" value="D3H35_11595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00279">
        <property type="entry name" value="YlxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007393">
        <property type="entry name" value="DUF448"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037465">
        <property type="entry name" value="YlxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035931">
        <property type="entry name" value="YlxR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34215">
        <property type="entry name" value="PTHR34215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04296">
        <property type="entry name" value="YlxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64376">
        <property type="entry name" value="SSF64376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YlxR" evidence="1">
        <location>
            <begin position="9"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="106" mass="12091" checksum="E246DBE71B266C3E" modified="2018-12-05" version="1">MRPRKIPQRKCVACQEMMPKKELIRIVRSPQGEITIDLSGKKPGRGAYLCGKVSCFKLAKKSKAFERALKVPVSADIYDRLEEDFIRAEDEFQASKELQDDDDDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLN4</accession>
    <name>A0A398CLN4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_15140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03142">
        <property type="protein sequence ID" value="RIE03142"/>
        <property type="gene ID" value="D3H35_15140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="144"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="144"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="245" mass="27509" checksum="80EE82BFA2BF8717" modified="2018-12-05" version="1">MSRPTILVVDDEEKMISFISSYLTNEGYGVLEASSGYEALEKLRSPQELGTIDLVLLDWMMPGLNGPDTCRKIRGFSQVPVIFLTARAEEVDKLIGLELGADDYITKPFSLREMEARIRVILRRIKPLQQSPSAAVAEPNRREADLIRRGSLTINLPNHSVSLHGQAVAFTPTEFKIVRTLAQSPGRVYSRLDLLEIALGEEYSGYERTIDTHIRNIRKKIESDFSDPEYIVTVHGVGYKFGEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLP8</accession>
    <name>A0A398CLP8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">YitT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_27950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00571">
        <property type="protein sequence ID" value="RIE00571"/>
        <property type="gene ID" value="D3H35_27950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006483">
        <property type="entry name" value="Membrane_protein_YitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="220"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE00571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="281" mass="30686" checksum="442D935B481BF252" modified="2018-12-05" version="1">MKKTVGWIAKTGPYIMMALSAAAVSCGFQLLLIPQKLLSSGVSGVAMIIGYVSGWNIGWLYFALNVPILIWGYRVLGRKFILLSMVTVIFTSAFMQFVPEHALTNDRLLACVFGGVLVGAGTAVTLRFGGSSGGFDIIASIISRHRDLPVGILVVALNAIVVAANGWLRKDWDAALYSMLSIYLTGKVIDLVHTPHRKVTAFIVTKQTDLLAAKLLTLPRGVTILKTRGGFTSNEQDMLMTVTTRYELTELRKIIRGVDPNAFVNVVQTIDVIGQFRRRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLS5</accession>
    <name>A0A398CLS5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000035">
        <property type="protein sequence ID" value="RIE03603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03603">
        <property type="protein sequence ID" value="RIE03603"/>
        <property type="gene ID" value="D3H35_10715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="96" mass="10841" checksum="CA14713A39391716" modified="2018-12-05" version="1">MNGIKSSLSARDGDFAELKLREIIVKLRYDDPERGLSFADEFAFKSAADRASFEYDYTAEGPAGYQIQIVRRFTNGLSNMIDWKTSDEPDVVVPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLX5</accession>
    <name>A0A398CLX5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_03580</name>
        <name evidence="2" type="ORF">D3H35_13865</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000022">
        <property type="protein sequence ID" value="RIE04919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01868">
        <property type="protein sequence ID" value="RIE01868"/>
        <property type="gene ID" value="D3H35_13865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04919">
        <property type="protein sequence ID" value="RIE04919"/>
        <property type="gene ID" value="D3H35_03580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="132"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="269" mass="30014" checksum="0130179A64B84857" modified="2018-12-05" version="1">MLEKMPADDTLLHEPPFTDEEVPYNLLFRICDSNDALRLKRSDGSLIYAQNPGLNGWLWMQRDLSDEEAQERLAELIEYLGDRPVPGVCARPATADFFAHAYAAARGYSYRTNMMLEAYRCEEAVKPLRVKGSLRSARRDDVPRVAEFLAEFAFDAFGLTVKPSSQVEDAESAVASGGLYLWQVQGLPVSMASIAHRSRRHARINGVYTPRNHRKNGYASALVAELSAVAASEGRNAMLYADKSNPDSNKVYRNIGFIESGNIKDIKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM05</accession>
    <name>A0A398CM05_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01898">
        <property type="protein sequence ID" value="RIE01898"/>
        <property type="gene ID" value="D3H35_14045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="153" mass="17563" checksum="38FF52EFFB57DEC0" modified="2018-12-05" version="1">MFNIRRYSTVDHDHVWRVHLLVVAEAGVEPTHQHYHDIFHIEEQYLQSGGEFLVGTDEQGHVVAMGGLKRLGEDQAEIKRLRVHPSYQKRGYGQQILNRLEDVANELGFRRIYLDALHNQNGAHKLFTNNGYQEKGPATIDGFDVIVFEKSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM23</accession>
    <name>A0A398CM23_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_10365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03693">
        <property type="protein sequence ID" value="RIE03693"/>
        <property type="gene ID" value="D3H35_10365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="115"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="339" mass="37843" checksum="2F41D7AD5E7ED51B" modified="2018-12-05" version="1">MCNIRSRRRLGCSSPWLALSLSFRLIDFPLNTRLEEFSKEDGAVMTGTNTTSAKAFRLLIGMFLLGAALLCLLPILNLLAISFSDKASTTANEVTFWPIGFNWKAYGLILNNDAFLHSTWIAVKRVAAGIAVNMILIVLSAYPLSLGSKQLKGRTFFVWYFVFTMLFSGGLVPLFIVVNKLHLVDSFWALILPYGVTAFNVIIMMSFFRTLPAALSESAMIDGAGHWTILFRIFAPLSLPALATLTLFSIVYHWNDWFTGLFLLSSNDKWPLQTYLYSQLYVGVDFSKLSPEEAKTIGSISNRSLRAAQIMVTIVPVILIYPFIQRFFIAGLTIGAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMD4</accession>
    <name>A0A398CMD4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LacI family DNA-binding transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00801">
        <property type="protein sequence ID" value="RIE00801"/>
        <property type="gene ID" value="D3H35_26800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="31" mass="3336" checksum="9BA0A15FE407FA62" modified="2018-12-05" version="1">MVTIYDTAAKASVSAMTVSRVIIYTGSWEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CME8</accession>
    <name>A0A398CME8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000034">
        <property type="protein sequence ID" value="RIE03625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03625">
        <property type="protein sequence ID" value="RIE03625"/>
        <property type="gene ID" value="D3H35_10645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="260" mass="29313" checksum="EE679A0577B693A6" modified="2018-12-05" version="1">MIGMMTEVSPEHTGFVARMYFDAIAQIFEMLYLTTRAYNFWALEHIQLSDVLGGSVKEVTYAGLLSAQNRILGLYKDAVGHFGTNCSYFPANQQKGISFKLTPLQLGFMKTNYEAMVNIPLQKHEADAKSPFAGLANVRITKVRCFLNGAKVKPGAPNSEVLLNITHSGQEQLISRDNAIYDFHHDKREVPFRYDLNDATIVIDGSFGESLQGEKTPYALFGPYTTWKIEVDKSFRSRIDLSELEEVTLEFHGTCYSFHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMF3</accession>
    <name>A0A398CMF3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_12255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03430">
        <property type="protein sequence ID" value="RIE03430"/>
        <property type="gene ID" value="D3H35_12255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="5">
        <location>
            <begin position="147"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="217" mass="23891" checksum="2C55B5916BC15F46" modified="2018-12-05" version="1">MVRIMVVDDHAVVRSGLVLLLDGKHGMQVVGEAADGDEAIRKGEELRPDVVLMDLSMPNGKDGLTATSELKKRLPDTSVLILTMHDDDEYLFRAIKAGASGYLLKSAPHEELLAAIRNIADGNAYLYPTATKKLMGDYLEKLKHGDHSGAYDSLTAREKEIMAKVAQGYSNKEIAELLQISVKTVETHKSNLMEKLGIRTKPDLVKFALKKGLLTYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMH4</accession>
    <name>A0A398CMH4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02439">
        <property type="protein sequence ID" value="RIE02439"/>
        <property type="gene ID" value="D3H35_17190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="272" mass="26934" checksum="F48C3603A7EF9CF5" modified="2018-12-05" version="1">MPDATTTPAEASGTAATPAANTADSGNATAPAANTADASNATAPAAATADVSNATAPAAATADVSNTAAPSALTADAGNATAPAAGAATTPDQQLKSLPQLGQDIIAATSDMLGVICKNWDNTKIWGATGALALNDIENYFKTTLQLKDDISSAITSLKGKVKGTPVGDALHSVVSGISTALKLVESKMTAVNSTADQAANFKTVVDQLLPKATSLLTAAGVDAAKFTGPVQTAGKLFDAAEAVVRFTNQVEGVIAFIVQNIDPEPDAAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMJ9</accession>
    <name>A0A398CMJ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01127">
        <property type="protein sequence ID" value="RIE01127"/>
        <property type="gene ID" value="D3H35_22180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="151" mass="17248" checksum="4B69CF308840BD88" modified="2018-12-05" version="1">MTTTTADREIVITRMFEAPRTLVFQAWTDNRHLARWWGLTGFTITTRSQDFRPGGEWRFDMHGPDGTDYPNKIVYGDIEPPERLVYIHGDDSDDGGHFEVTVTFEEQGSGTLLTMRSLFPTAEERDRVVREYGAIEGGKQTLDRLAEFLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMK3</accession>
    <name>A0A398CMK3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03480">
        <property type="protein sequence ID" value="RIE03480"/>
        <property type="gene ID" value="D3H35_12565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="147" mass="15912" checksum="5102C11F2B522DBA" modified="2018-12-05" version="1">MSSASRGIQIGPPRFKIAVHSVVWLANSGGILSSAMIADQVQSHATFMRRVLQSLAVAGIVESRGGREGGYLLRKKADELTLGEIYCAVSAEPAESVDDVDCGEAGVQLDAELEKILFEAERLTVEHLRQYTVADIMGRVEFFCPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CML0</accession>
    <name>A0A398CML0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_22265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01137">
        <property type="protein sequence ID" value="RIE01137"/>
        <property type="gene ID" value="D3H35_22265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="2">
        <location>
            <begin position="23"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M41" evidence="3">
        <location>
            <begin position="141"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="359" mass="39979" checksum="009DC9DE058325E5" modified="2018-12-05" version="1">MDPPNIDGSRIAKLLRTLGLRRRKAERPAVLTIAATNLPDVLDDALLRPGRFDRKLWVDSPDYDGRVDVFQYYLRKVKLDATLTPELAALDTVGYSPAQIKHIVNESVVIAHQRGAPLAGYEDFRVAMETYEWGLKQPLRSMSEDEKRNVAYHEAGHAVAQYLLKPHDRVWKVTIIRRGGALGLAATKPMSERYNRSDSEILAEIQVCLAARAAEETFLGKKLNGVTSDLQQATELAGVYLGMLGMGDELFSWQASGGTRADALKALRPRINELLRDQMLQVKKLVLEHAEFIHVISEELLKRGDLTGEEIEMIYSELYGRSRPVPPAINWRNISDLPDAEATTAAALEEAGDDPASKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMM9</accession>
    <name>A0A398CMM9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_21345</name>
        <name evidence="3" type="ORF">D3H35_29470</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00174">
        <property type="protein sequence ID" value="RIE00174"/>
        <property type="gene ID" value="D3H35_29470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01003">
        <property type="protein sequence ID" value="RIE01003"/>
        <property type="gene ID" value="D3H35_21345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="69" mass="7641" checksum="6D0EA243D88A513F" modified="2018-12-05" version="1">MRMSRTVNVALREKKRQQIIDAASSLFSTRGFFATTVSEIAKEAGMSHAAVFTYFSSKEELLDAIIQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMQ8</accession>
    <name>A0A398CMQ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02078">
        <property type="protein sequence ID" value="RIE02078"/>
        <property type="gene ID" value="D3H35_15060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="313" mass="36453" checksum="5F4D3FC1F4363D23" modified="2018-12-05" version="1">MTKPNSDRVAVLLSTYNGERYLEDLLDSLFRQSHLNFDLFVRDDGSDDKTLRIIEEYRQRYANIRIVSSECNLGPKKSFGTLLEVALKYSTYAYFMFADQDDVWMDDKIAKSLRLMRENESEDDSLPVLVHSDLIVVDSELNRIGPSFWGYQKLDPDKDGINRLLVQNVITGCTMLINRKLAELSVPVPDECIMHDWWIGLIACSNGRIRYLREPTIFYRQHGRNSLGAVKFDLPYMLSRFKRMKGIEWNVVQASALISRIGGEVEAVREFADLRNRSYASRLYTVWRRKYYKNGFIRNIGLFLQLAKLKKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMW7</accession>
    <name>A0A398CMW7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-antigen ligase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_09690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03815">
        <property type="protein sequence ID" value="RIE03815"/>
        <property type="gene ID" value="D3H35_09690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017188265" evidence="4">
        <location>
            <begin position="16"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="487" mass="53680" checksum="13ACE50DDBC56466" modified="2018-12-05" version="1">MFLLKKMNGKSMVSVCSAIAIALGSSMLLQWLLQRGSSFTLFFVVFVVIGIGYALACCLYDPLKVYLAGSVFLMMINAKVIFDPVTDYIGGVGAGKFYAGVPHLVVGLGIVSFVIDKLRFPDRLSFRIGKSEFYVILFTVITLTAGLVAPFKAASVVQSNFYIVLLALYLLWSNAFRSLGRDRATKLFVRALSVGMLVQFGLCLLQLSLGKEIGLAFIGEGVLEERAGLNGSSITGTFNHPGPLSLFFLIGVSLLFPLVLQKRNFSAVVCFIAAIVGLVLTYSRTSLVIGAAVLLLEWLVLAYFSNKISKNRAALVAIVVIVVAFSMGDSIAARFSSLENNSNDDQIAHRLDHYRMAWDYIQQKPWLGNGLNNWSYVTQHTQLLTSVGSDIFYYTNPVHNIYLYVWFEGGLLMLAGFLLVIIHTLIGLLRKIKRRKELDIGLIASIVCVLAYGITGWGLFNGGQMLYIFYFILCVSNIKSDELAEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMX5</accession>
    <name>A0A398CMX5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_25525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00931">
        <property type="protein sequence ID" value="RIE00931"/>
        <property type="gene ID" value="D3H35_25525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017414238" evidence="2">
        <location>
            <begin position="34"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="208" mass="22987" checksum="9FE087A3A7BD17B3" modified="2018-12-05" version="1">MRNFKVLGVLTLVLVLSVSLLAGCGNGSSNSNASPSGTAIDTGASNSDTGSADSQPKKKLRFFTKGNENNADYRVMKSLIDQYQKEVNPNFEVEIESIPNDTQYFQKLRTYIAGNQLPDFFKIPNGLLSENLAKQGRLVDIKATLQEFGMFDEFNKAAIDFLSFSDGNLYLFPRANTAKPSGITRSRSKKTTLKYLQPSTSSSMRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN14</accession>
    <name>A0A398CN14_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02639">
        <property type="protein sequence ID" value="RIE02639"/>
        <property type="gene ID" value="D3H35_18335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="103" mass="12017" checksum="BF5F95006CBF0533" modified="2018-12-05" version="1">MKMGQEKHSAPLPTARSIRRACSNELYRTAKRLKQYVPADKMEQAEKLYVKRVIGHLLWIADNRSNRKALADWWEKEVSAEIAELWNVDRTRLSEAFRQAFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN55</accession>
    <name>A0A398CN55_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation histidine kinase inhibitor Sda</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01011">
        <property type="protein sequence ID" value="RIE01011"/>
        <property type="gene ID" value="D3H35_21395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015064">
        <property type="entry name" value="Sda"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036916">
        <property type="entry name" value="Sda_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08970">
        <property type="entry name" value="Sda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100985">
        <property type="entry name" value="SSF100985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="84" mass="10031" checksum="05F049BB35BDA0C4" modified="2018-12-05" version="1">MNQKAYPYLVKPNRQPEIPLRFDEPIDYVPARRLSDKAALLRPLQDEHLLEVYREAKKMNLSSEFIELLEEAISIRQLEHRREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN98</accession>
    <name>A0A398CN98_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_28610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00384">
        <property type="protein sequence ID" value="RIE00384"/>
        <property type="gene ID" value="D3H35_28610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="DUF4981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bgal_small_N" evidence="5">
        <location>
            <begin position="215"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="492" mass="54554" checksum="16312AC849EE2FB0" modified="2018-12-05" version="1">MGSGSSIPRLLGGLIWEWSDMGIVRYAEDGKPWYAYGGDFGDEPHSGPFCMDGLLFPDRSLKASILEYKKAIEPVVAEAVDMASGLVRIRNRYHFLTLGHLTAEWALMREGVRVDGGILEQLNTEPGASETVTLPLVRETIAAEGEHWIHLRFALSDDTLWANAGHEVAWADLLLPAMEQETGTERLVQAAVKEPHRTKEQSPALTVTENGKTAVAAGADFRIVFDKLTGRITEWTREGKSLLLAGPKLNVWRAPVDNDVHLAKEWKKAGYDRLVQLVKSFSLEREETRRCRIRVELVLGASGEGIAFRAELSYTVSSEGWVEIEASMESLKDLPSLPRFGLELRMPAGYDRLSWFGKGPHECYPDRKESGKLGLYEGTVMEQFVPYVKPQENGNKSEVRWSSVTDSSGAGLRFAGAAPFELSVHRFSTEDMTLTDHVHLLTALDETIVKLDAGQSGIGNHSCGYAPTLDKYLLPSAKAYFKMRLESIAVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNA5</accession>
    <name>A0A398CNA5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04093">
        <property type="protein sequence ID" value="RIE04093"/>
        <property type="gene ID" value="D3H35_09115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="176" mass="19921" checksum="030DCB0D5588266A" modified="2018-12-05" version="1">MAAILCPWCQSEIPVEEGQGPDKFCPVCDNEIDGYRTLRIGIDEEDEEDEEDGDSVGLVRAEDEEDLSWMQDDELQEKDEALIQFEEAVEELLDEQEVVPECPQCREYMLETGQQIVTAEQFQPRVSKLLASKGGKVLEAPFALTVYLCPSCFAVQHALSESGRDEIVRRMAEEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNB7</accession>
    <name>A0A398CNB7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_28750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00404">
        <property type="protein sequence ID" value="RIE00404"/>
        <property type="gene ID" value="D3H35_28750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022627">
        <property type="entry name" value="DUF3502"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12010">
        <property type="entry name" value="DUF3502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017410688" evidence="1">
        <location>
            <begin position="20"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3502" evidence="2">
        <location>
            <begin position="348"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="488" mass="53693" checksum="90FA9B978AA10578" modified="2018-12-05" version="1">MLALTLALSACSSGKTENAENGSASGEKPYEVVYAYPTFDNVPPDIQQVQDEINKISKAKINVTVKLMPISSSAFLNQINLMMSGGEKLDMMAMFNYSTQVSKGVLYPMGNIMEQNAQGIIDALGPDYYNATKVNGISYGVPSIRDLAQDYGFVVRKDLVDKYKIDLSQIKTFDDLGNVFKVIKENEPGMVAATNQTNDSILGSYELDDPLGNDLGSLLNNGQDDLKVVNWFASEEYEHMLRKLREWYLAGYLLKDAATNPESNAAVVKSGKAAGYFSQMKPGFEAQESRVNGAEMVAVRTLPPVAKTDTVTNVTIGISAQSKNPEKTLQFLNLMYTDKDIVNLLDWGIEGKHYVKVEGQDNVIKYPDGITAQNVGYKNYSWMHGNQFLSYVFEGDDPDVYKELDAFNKSANKSKALGFTFNGESVKTEIAACTAVLTQYQRVLQSGAVDVDKVLPDFLKKLSDAGIDKIIAEKQKQLDAWAAANGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNI7</accession>
    <name>A0A398CNI7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AbrB/MazE/SpoVT family DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_08885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04055">
        <property type="protein sequence ID" value="RIE04055"/>
        <property type="gene ID" value="D3H35_08885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="5"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="80" mass="9136" checksum="3136C97C0E6ABE55" modified="2018-12-05" version="1">MKPAGVVRKVDQLGRIVLPKSLRKRYQMNEGDPVEILVQGDHIILERYRPRCVFCTSMEGVSEFKERYVCSACMSEMGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNI9</accession>
    <name>A0A398CNI9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04173">
        <property type="protein sequence ID" value="RIE04173"/>
        <property type="gene ID" value="D3H35_05985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="211" mass="23857" checksum="612782506A24DE55" modified="2018-12-05" version="1">MKRIVVTLNWPLLRNRWRRILITGRAYFILSLGSMLVFVMLGLAGMLQNAVAASPVQSMKGFAASLSGGFFGSLLGMELPHMKTAKEDSPLKSDVVASFLIRFLTNLNPDDPKACCPPRCRECFRTSLCCSEPAPEERRSPLRITVRSNRRSEAERMTMGRRLRPKSQTRHCRRMDNRTAVRNFRAIASCRQRTRSGVHGRTQGCVHLSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNN7</accession>
    <name>A0A398CNN7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spore coat protein CotJB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_08230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03942">
        <property type="protein sequence ID" value="RIE03942"/>
        <property type="gene ID" value="D3H35_08230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024207">
        <property type="entry name" value="CotJB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12652">
        <property type="entry name" value="CotJB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0946">Virion</keyword>
    <feature type="domain" description="CotJB" evidence="2">
        <location>
            <begin position="32"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="107" mass="13157" checksum="8B7C8DC74B03A827" modified="2018-12-05" version="1">MVERRFRELRDQREEKTEEKQPERGNEAYRKELEELQKVDFALVELTLYLDNHPTDMQSIQQFNQLAQLRGQLAYAFEMKYGPLMQYGHSFSRYPWQWIESPWPWQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP15</accession>
    <name>A0A398CP15_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00664">
        <property type="protein sequence ID" value="RIE00664"/>
        <property type="gene ID" value="D3H35_27260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="600"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1135" mass="120715" checksum="AA79F3DB79939731" modified="2018-12-05" version="1">MLKSKFGFGTNSKQRIGAARKPRRVWKSGLASLLAAVIVTGGLEQLAYAEPVQARGVDPSLLELLDKLGMGEDQPSVGDDVYGEEKGRLSFTNAVYGLPTKISSAPEGAPGTGDSKSASISGDGRYVAYASVSSNLVAGDTNGKQDIFLLDRTSGTTKRISLAAGGVQADGDSYAPFVSLDGSMVLFTSKATNLTSGDTNRNEDLFLYDDKLGAVQRLAEYVPGSEFAGAGSSYQISADGRYVAYAGKTSSQGTCDIWLLDRRPNTLTGKPDAAKLIVRQKYIYENFRSRLSISADGRFVAFDSLSPDVTPDDIVPNNSPKYRDVYLYDAAKDEMTKVSRGPDGKGGNNNSYYPAISADGQYVAYLSKASNIVAADTKSSQDLYVYNRLNRTTELASVDSGGVQPGVDVYDPSISADGSYVSFHTDGAFDPADAGRTDVYIRDRKAGETRWISKTAGGANADQPADRATLSADAGTIVFETKATNMGSSSDPDSFIDIYAAALPSGASAPIWPEEAVVTAASGAAYVSLSWPEVDGAAYYKVMQDDRVVGIVTGASFAAEGLKPGTEHRYRIAAGSSGYAWSGWSAEATATTLAAPETTAPGRTTANAAGVLGGAQVSWVYPSDPDVVGAKVFWRKTFGAAQFGPTRESVLYPKSVASALVPNLENGQFYEFAVAIVDGDGNRSVSEWVRIKLPAGPAIVRLDVRASDGRPAGSDTPRIADISGDGRYTLFLTEAQGIVPGDDSVNPGDSYTPTTDLYLFDAELGATQLISRTPGGKSANSNSNGGSISDDGRWIVFGSRASNLTETADTNGKWDVFLYNRDVNGNGVYDEEDDTSLTKISTPLANNGQANGDSSGPVISADGSTIIFSTNAVNLVNEPPAGNDYYNIILGTESRELKPLLLPDGRSPGASSDSIDLSADGKTIAFNSHKSFVPEDTGSSDFDVYWYDWHDPNATKLVWLSGLIENRKYSGTVKVDSSGRYAVFNITLQNNSYMSYVFDSAAPAGTVPEPLMTVPASSPMTLDYITSHSISGDGRYVLFSSQGKNIVPGDTDNVTNLFVRDRLEQKTAMVSLPYDPSIKIMVYSSDGMLSRDGTRFAFRSSMMNMVSGSERSKMGLYVQRIAVTEPSASWRRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP32</accession>
    <name>A0A398CP32_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_27325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00674">
        <property type="protein sequence ID" value="RIE00674"/>
        <property type="gene ID" value="D3H35_27325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017400336" evidence="2">
        <location>
            <begin position="41"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="243" mass="24785" checksum="5011414660073A46" modified="2018-12-05" version="1">MKKWKKTVVTLTVLLAVSAVAVPLAIACGAQSNNKNSAEAAAVQSDSRKKPGKKPAPAHAAPKPSAGPAAGAESSSMTDRNGYSIVITGGYETDAQDHGRPIALIAAALGVPDAVFRQAFSGVTPAGAGSSGPTSEEAQSNKAALMKVLSPYGITNERLDEVSNYYRYSGVKGETWKRTPATLSTTVKDGVVTGVTITNAGSGYSSAPTVKITGPSGTYTATATIAYTKDFKTNGSISSIAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPF2</accession>
    <name>A0A398CPF2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phage_base_V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02588">
        <property type="protein sequence ID" value="RIE02588"/>
        <property type="gene ID" value="D3H35_18060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="1">
        <location>
            <begin position="19"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="235" mass="25354" checksum="30A1A093C2E8AFFD" modified="2018-12-05" version="1">MFNYPPQQQQAGIINGVMIAKVTNNKDPEKLGRVKLKFPLRENEHESDWASVTTFMTGGSRGSVFIPEVDDEVLVAFVLGNLNMPIVVGSLWNKNSKPPTPDENNNIRKIVSKHGHEFIFDDTSSAAKVTLKSKKGMQLEFVDQNDKVEIKAGSTGPVVTLEGGSSGTLTLKSGTNKITIDNKGNINVDSTTGITIKSTQIKVEATAQMTLKANASLNLESSGIVNIKGSLVKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPR9</accession>
    <name>A0A398CPR9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01451">
        <property type="protein sequence ID" value="RIE01451"/>
        <property type="gene ID" value="D3H35_24135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="49"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="145" mass="15900" checksum="209049143BFEE040" modified="2018-12-05" version="1">MTVSQTTVKTAEAMEWSLMPDHVALYHREIVSAAEADAMGVRASSVLWEKIGVGGAVLPHYHNVAEIIHITVGKVRLLCNGEWKSYQAGDTFHVPAGVVHSVVNDDTAPTEQISIFLPVEEQVPPNRFFETTQVAIPTERPLQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPS9</accession>
    <name>A0A398CPS9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04190">
        <property type="protein sequence ID" value="RIE04190"/>
        <property type="gene ID" value="D3H35_06100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041532">
        <property type="entry name" value="RlmI_PUA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17785">
        <property type="entry name" value="PUA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="459" mass="51119" checksum="9BFB9AEE940626F7" modified="2018-12-05" version="1">MANQARAVLSRSRRPRLEQGHPWIYANEIEKWEGEPPEGGLVQVVDHKGKFLATGYANPVSQITVRVVAYSPLEEMNGVFFRERFERCAAHRARFVSDHLSCRLVYGEADFLPGLVVDRFSDILVVQVLSLGMEKARDAWLPALIDVFSPKGIYERSDVGVRALEGLEERTGVLYGDCPRYTEIEENGLKIEVDIEGGQKTGYFFDQRENRASIAPLMKGWGARSGILLQERAADDGQLQSVPVNKSGNVVTYPYWDGATVLECFAHTGSFTLHACKYGAKKVTCLDISQHAVGTAKRNVDSNGFGDRVEFEVADAFEYLRRQVAGREERTARGAGQKTDTSKPLTGDGRTWDVIILDPPAFAKTKRAVPSACRGYKDINLQAMKLLNEGGYLVTASCSYHVRPELFLETIQEAAVDAGKILRRVEWNGAGKDHPQLAGVEEGHYLKFGIFEVRTKREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPY8</accession>
    <name>A0A398CPY8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Efflux RND transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000002">
        <property type="protein sequence ID" value="RIE05476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05476">
        <property type="protein sequence ID" value="RIE05476"/>
        <property type="gene ID" value="D3H35_00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="41" mass="4630" checksum="E200ABCDE57FDE77" modified="2018-12-05" version="1">MLVGIVVTNAIVLIDRVRQNEETMTIREALLEAAERGCVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPZ5</accession>
    <name>A0A398CPZ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_05770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000026">
        <property type="protein sequence ID" value="RIE04512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04512">
        <property type="protein sequence ID" value="RIE04512"/>
        <property type="gene ID" value="D3H35_05770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="3">
        <location>
            <begin position="22"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="94" mass="10080" checksum="39DABB65983E83AC" modified="2018-12-05" version="1">MSGIAGALAVVLIGLIAVMIRRRIVLPLIRFKLFLGGVTEGKLSDELSVKDTRRTDEVGSIARSLQEMTGQLRTIVSGIRSTASVTAESRGIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ08</accession>
    <name>A0A398CQ08_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CPBP family intramembrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04615">
        <property type="protein sequence ID" value="RIE04615"/>
        <property type="gene ID" value="D3H35_03735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="198" mass="22892" checksum="FC401BAD2D6F1190" modified="2018-12-05" version="1">MKKFDIRKIKLRQVTVDELNDKMLLVNLYMTQAITLIIGFAWMFFQSRNPFALFKWPGSWNFALWGAGLAALVLIVDLILSRWIPEEASDDGGVNERIFKNRPFWHIVVLSAIVSICEESLFRGAIQQAIGPYWTSIVFAAIHVRYLRHWIPTGLVFSISYGLGWIQVQTGTIWAPIAAHFLIDFIMGCIIRYRREQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ85</accession>
    <name>A0A398CQ85_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01591">
        <property type="protein sequence ID" value="RIE01591"/>
        <property type="gene ID" value="D3H35_24920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="73" mass="8440" checksum="D127D2C878318427" modified="2018-12-05" version="1">MGEKVVIKIPELLKKHGISLRELSRLTDIRHAALSELSSQKRQNINFNHIEKIAEAFDIHDIREIIDLVETKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQM8</accession>
    <name>A0A398CQM8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_05090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04843">
        <property type="protein sequence ID" value="RIE04843"/>
        <property type="gene ID" value="D3H35_05090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="339" mass="35006" checksum="5D4E48F0DDF9DE3C" modified="2018-12-05" version="1">MIEKKTTSWLSIKWAGLLLGSLLLLLIFCCSIVYGATPTGWDDAISSIVRYDESVNEQIVVRTTRIPRALMAASIGASLAVAGSVMQAVTRNPLASPSILGINGGASFAVVFAITVLHVGQQGALVWISFAGAAFGAASVYTMGAMGRGGLSPLKIVMAGAAMSALFMSFTQGLLAGNESGLQDVLFWLAGSVAGRPIELLTAVIPYMTAGWLGSLLLARHLNILASGEETAKGLGQRTTAVKLAAGAIVVLLAGSAVAVAGPIGFIGIVIPCIARFFAGTDYRWSIPYCAILGAALLLSADLAARFIIMPEEVPVGVMTAVIGTPFFIYIARKGGVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRE7</accession>
    <name>A0A398CRE7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-oxoacid:ferredoxin oxidoreductase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_11795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03358">
        <property type="protein sequence ID" value="RIE03358"/>
        <property type="gene ID" value="D3H35_11795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011896">
        <property type="entry name" value="OFOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032686">
        <property type="entry name" value="PFO_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12367">
        <property type="entry name" value="PFO_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02177">
        <property type="entry name" value="PorB_KorB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="3">
        <location>
            <begin position="48"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="PFO_beta_C" evidence="4">
        <location>
            <begin position="199"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="288" mass="31547" checksum="9CABD58969BD63C3" modified="2018-12-05" version="1">MATFKEFRNNVKPNWCPGCGDFSVQAAIQRAAANVGLEPEQLAVISGIGCSGRISGYINAYGLHGIHGRALPIAQGVKLANRELTVIASGGDGDGFAIGMGHTVHAIRRNLDVTYIVMDNQIYGLTKGQTSPRSAEGFKTKSTPEGSIETTLSPLEIALSAGATFVAQSFSSDLKQLTMLIEEGLKHKGFSLINVFSPCVTFNKVNTYEWFKEHVVNLDQFPEHDPSNRMAAMNKIMETNGLLTGLIYQDKVRKPYEDLAVGFKEQGLAKQSLELTREEFDKLVKEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRN0</accession>
    <name>A0A398CRN0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Efflux RND transporter periplasmic adaptor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_04960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04820">
        <property type="protein sequence ID" value="RIE04820"/>
        <property type="gene ID" value="D3H35_04960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="5">
        <location>
            <begin position="76"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="513"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="138"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="550"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="573" mass="58097" checksum="4475E3CC9CE3EF3A" modified="2018-12-05" version="1">MTLCNIIANEITVESGARGMKEGRGASVRWKKWTLIGLSVIVVGGGATGGWIYWKKDDKPLAAGYSTTVVRKGTLEVKVSGTGTIEPANRQSIKASSGNSTIKSVLHKEGDTVKKGDVLATFEQTDVSSQVKSKQLELKSKKLDLTDLQTKYKTAEDDDSRASIALSIQKQQLNIEMAEADIESLQEDNSIDPIVAPIDGQLTGFDLTAGDALGQNTDLGEVVDYTNLQMVVGVDELDISTIKKGQKAQISVEAISEKTYEGEVVAIADEGTASNGVSSFDVTISVSEPVNLKAGMSAEANILTESKENALYLPIEAVQSLQGQYYVMVPASGSSQGTGTGPSGGQGAGQGAANGANGQAGQTGQTGQAGQSGQGTQAAQSGQGAKTDNQTGTAPQNGQTGQAAPSGGAGQSGQAGGAGGQGGPGGGFGNMTDEERQAMREQFQNMSDEDRQSMRSQFSGGRGAGAGVAATTTGVTATSRVNVEIGIKNEDSIEIVSGLTEGQQVVLPTVTSSSSSQQNQGFPGGGFGVGGITGGAIGGGGMPGGGFQGGQGGQRQTTTTTRQSSGGTGGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRQ0</accession>
    <name>A0A398CRQ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03468">
        <property type="protein sequence ID" value="RIE03468"/>
        <property type="gene ID" value="D3H35_12485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017479049" evidence="1">
        <location>
            <begin position="24"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="375" mass="40395" checksum="1706C90AA7AD8C61" modified="2018-12-05" version="1">MNKKKAILIATVAGVIATTASVGASGILEKVSGLVRKDYQISVNGEKTSLTPVFINGQAYLPVRSAAAALGYELQFDGANKEIDLTERSKEEAADYMRMNGVIVTAQPVDNGQYRIELLGRGDSNWIILYVDDKTALTDAEGKAVAAKDLKPGMQATAEFGPVVALSYPGQSHAAKLSIGAERLIKEDVIQSVKHTDDGWQVQFGESKDGAAVPTLILNAGKETSVLTAEGQSVAFEDLKAGDRVRAYYGPIMTKSIPPISPLYYLVLLAPDNGQQIAPAEAQQFRDLAWNQLSDDQKTHLTTARNDAVVDVVSAKESGVFPSDDAQKKKLEELKAANAKLVTVTYHTDQDALLGPLTAAFSLETKEFIGYYIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRR9</accession>
    <name>A0A398CRR9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_17415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02477">
        <property type="protein sequence ID" value="RIE02477"/>
        <property type="gene ID" value="D3H35_17415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="88"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="316" mass="35690" checksum="DDAC0CC17D6D8E83" modified="2018-12-05" version="1">MEANTARQANLKAARQTKKMRGYKQPWMLHFMVLPAVLLVFVFSYVPMTGIVMAFQNYKASLGITGSPWVGLQHFRYMFENEYFVKITWNTLLFACSKIAMNLIVPFIFALLLNEVRNMGLKRSIQTLVYLPHFLSWVTLSGILIDLLAQTGLVNQFLTSAFGIKPIFFLGDGTWFRLTIIFSDVWKEFGFNTIIFLAALSGINPALYEAAEVDGATRLKQTLHITLPSLVPILIVVGTLALGNVLNANFDQVFNLYSPMIYQQGDIIDTFVYREGLLSGQFSFATAVGLFKSMISLILIAISYRLAYKFAGYRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRU5</accession>
    <name>A0A398CRU5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_12070</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03518">
        <property type="protein sequence ID" value="RIE03518"/>
        <property type="gene ID" value="D3H35_12070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017371682" evidence="10">
        <location>
            <begin position="29"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="11">
        <location>
            <begin position="35"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE03518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="402" mass="42483" checksum="FCE519BDC44E4748" modified="2018-12-05" version="1">MHRYARAGLSIVVFLVGIGGLAGTPIGAEPGSAVQSEPAIQSESAILIDADTGIALFGKNANTRMYPASITKMVTAILALETSDPDETVTVSRTAREEEGTRIYLAEGEQKPMGDLLYGLMLNSGNDAATAIAEHVDGSKEAFSNRMNEFVSGKLGLTGTHFTNPSGLPDEDHYTTASDMAVIAKYAMQNPTFRAIVSTKKMAWNGLEWQSSLINHNKLIGTYEGATGIKNGYTVAAGSTLVASAARGTKSLIGVVLKAPSSNAVYDDMKKLLDYGFAAFEPRELVKAGDVFAAGSGESALEFKAVSSLSPLVRNDIQPQLSVGEDGRLWMSSATGAQVVAQLEQVKPAESVRISSSDAAASEDSAPGHRRNPVSVITLVALAVFCAIVVLRVRKKRRIKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS14</accession>
    <name>A0A398CS14_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type III-B CRISPR module RAMP protein Cmr1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cmr1</name>
        <name evidence="2" type="ORF">D3H35_00880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05372">
        <property type="protein sequence ID" value="RIE05372"/>
        <property type="gene ID" value="D3H35_00880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007522">
        <property type="entry name" value="CRISPR-assoc_prot_TM1795"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01894">
        <property type="entry name" value="cas_TM1795_cmr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="467" mass="53785" checksum="42DFD2F481386392" modified="2018-12-05" version="1">MEVNVEAPDLQKVEQWIESAGKNLFEQYPITVVTSAIIGKDLQDHMNGGEPRISSIRGHLRFWWRATRGAKYKDAHDLKVWERQIFGDTSLPSPCKLKLTSVVKNGRKEYSSIPTYVSFPYRDQKKKNKDKNKEEMQFKVFEAAQKNRGLSFILQIDYLDSLEYLQGQEKPHRWLTAIEVKNEVEAALWAWINFGGIGARTRRGCGSLYSAFFSPQAATSEELEGWIKQCVAEYRLPVLNANEHREWPILALLTEQQNSIAVQEQPDAVMKAWEETVRVYSKFRQKRNWKKDINRKPQPGRSHWPEPDSLRRITGQSTQLHKSPVSLNPKDDIAFPRAQFGMPIIFRFKDNIDGKGDPPETELVPLNKKRLASPLILKSLAVSEDKAFGAMICLVQPPLERLQLSSSDASPEVKEKVENQTINKKQIYPEKIENSLYPLRNSVPNAVEGFLRSEVVRQWKKMQPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS88</accession>
    <name>A0A398CS88_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000006">
        <property type="protein sequence ID" value="RIE05413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05413">
        <property type="protein sequence ID" value="RIE05413"/>
        <property type="gene ID" value="D3H35_00560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="35" mass="3927" checksum="AFDD18EE749A1B04" modified="2018-12-05" version="1">MQPLRCFSRGVFSRTTVSEIAKEAGMSHAAVFTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSF0</accession>
    <name>A0A398CSF0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02301">
        <property type="protein sequence ID" value="RIE02301"/>
        <property type="gene ID" value="D3H35_16390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="68" mass="7750" checksum="0E541C9D873B976C" modified="2018-12-05" version="1">MNKTAYIGLVQAARARDQREPVTVWIDDKPVETGVIEELTEEYILVNGSYYLIRVVHLSFADEPIEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSJ4</accession>
    <name>A0A398CSJ4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_02080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05180">
        <property type="protein sequence ID" value="RIE05180"/>
        <property type="gene ID" value="D3H35_02080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016767">
        <property type="entry name" value="UCP019853"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019853">
        <property type="entry name" value="UCP019853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="129" mass="14589" checksum="A9C76D2AFEE54CA4" modified="2018-12-05" version="1">MQYTTKLVELSPLIEEEAVLEIHGQRIVAFINNCPFEIDKGGQYLIEIELSILDDFIISQADSDGNGIKQIENGFSHFISGILNIDSGTIDVGTGILFEIDREFLFDYGYLHNQYVQIRVDRLSVDFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSY6</accession>
    <name>A0A398CSY6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDP-2,4-diacetamido-2,4, 6-trideoxy-beta-L-altropyranose hydrolase</fullName>
            <ecNumber evidence="4">3.6.1.57</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pseG</name>
        <name evidence="4" type="ORF">D3H35_15025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.57" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02074">
        <property type="protein sequence ID" value="RIE02074"/>
        <property type="gene ID" value="D3H35_15025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020023">
        <property type="entry name" value="PseG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03590">
        <property type="entry name" value="PseG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_tran_28_C" evidence="3">
        <location>
            <begin position="197"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR620023-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR620023-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="365" mass="40735" checksum="33B550787E5BD046" modified="2018-12-05" version="1">MQVVIRTDASVRIGIGHVMRCLTLAASLRKNGAFVQFVCREHPGHLCDYIQHQGFAVQRLDAVQRSEIDESSQQGYESWLGDSWSRDADQTSDIMSRNRSSVDWLIVDHYAIDSRWEERTRKLANRTMVIDDLANRVHSCDVLLDQNLYANMEGRYRSLIPESCLQLLGPRYALLREEFQNARKNARTRSGSVRRILVFFGGSDPTNETEKALKAIKRLQQSDILVDVVVGGSNNRRQHIEALCSQMANVHFHCQIDYMSELMAKADLAIGAGGSATWERCYLGLPALVVTTAANQVEVTEAVSRAGALIYLGHFEQVSAQTIFDALLVLLSRLEEVSGMSRKALELMPAAESGGAEYVAGLLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT04</accession>
    <name>A0A398CT04_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05290">
        <property type="protein sequence ID" value="RIE05290"/>
        <property type="gene ID" value="D3H35_01670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="108" mass="12339" checksum="4D833B1FF292CE13" modified="2018-12-05" version="1">MEPGRQAWQRPVESRKTGRYGRLVFQSPLLSGPVQPGSLGIEAMLQLLQFHMLQEEMDAGMTRARFEPLVRGWRSCGNTEARSRRGTTKSLLTSIFWRRAATIMVFMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT07</accession>
    <name>A0A398CT07_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_20345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02957">
        <property type="protein sequence ID" value="RIE02957"/>
        <property type="gene ID" value="D3H35_20345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="93" mass="10672" checksum="692012A912188B16" modified="2018-12-05" version="1">MSIFLGLGLTQNFSSWDQLFLDDPIQSMDDIKILSFIDVLRAISDSNFKKQNLIISTHDDNFAKLLAIKYRNKSLTQYNFIGYGLQGPLIQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT57</accession>
    <name>A0A398CT57_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04439">
        <property type="protein sequence ID" value="RIE04439"/>
        <property type="gene ID" value="D3H35_07595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="150" mass="17605" checksum="5537B81F38074AA5" modified="2018-12-05" version="1">MKFKMKVANTYRIIYQFGAEIQSLTGYFDKTLNAIQINQLPEENLMETEYTIHALTQFCADLKEVKLPIIEEAKKYALDLSDMKDFLDEYYKALNYYSEAYTLLNGYYKTGSKKDLEDKQTALNKAGEVARMPYQYATAKYYDYYNATQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTP5</accession>
    <name>A0A398CTP5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sensor histidine kinase</fullName>
            <ecNumber evidence="15">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">D3H35_18650</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="15"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02681">
        <property type="protein sequence ID" value="RIE02681"/>
        <property type="gene ID" value="D3H35_18650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017202">
        <property type="entry name" value="LiaS/VraS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037431">
        <property type="entry name" value="STHK_LiaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 15" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="18">
        <location>
            <begin position="71"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="17">
        <location>
            <begin position="150"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RIE02681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="349" mass="38826" checksum="7AB538F59168676B" modified="2018-12-05" version="1">MESRKVTNMIWRHMGEGILFSLCIGALVIYLLISNGLAGDFTEWSTVISYILTAIGVLTAAGAAFGFWRGYPIRQRVEALSEAMAQLEKGAPVAALPDLGKDEIGRLGDRFAKLGRKWEEQVASLQRLSTNNAELETKARMSAIVEERQRLARELHDAVSQQLFAISMTATAVGRTLDHDFERARRQVELIEEMASVAQSEMRALLLHLRPVHLEGKRLSQAIPELIEEMKAKVPVEIGLDMDDDLPLNKGMENHLFRIVQEALSNTLRHSKATRMDIVLHRRGEVVRLGIRDNGIGFDPEAKKHASYGLVSMEERVNELGGSWNVASAPGKGTRIEIRVPIMAEGELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTU1</accession>
    <name>A0A398CTU1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1861 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02384">
        <property type="protein sequence ID" value="RIE02384"/>
        <property type="gene ID" value="D3H35_16860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015045">
        <property type="entry name" value="DUF1861"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37036">
        <property type="entry name" value="PTHR37036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08950">
        <property type="entry name" value="DUF1861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="315" mass="35190" checksum="2EFCC9A93E714FC0" modified="2018-12-05" version="1">MLAYTEQASSCAKLLERFRKEQPNSRGTKLIFSGVGARDVYNITAPFMDDGEPVIAGRVEDRSKEESEVIFFVNRNGEWVPRNGAPVFALQDPFVAFVHGEIVFGGVEVYFDGNDPHYVTSWRTVFYRGTRIGSLEPFAKGPLTMKDIRLIELENGKIGIFTRPMFVEGARAMIGYAEIDDLSELAEEAIDRADLMRQMFLPDEWGGANEAHLLSNGKIGVLGHIACMEHNNIRHYYPMTFAYDPADRSYTAVKLIAARDMFLDGPAKRPDLKDVLFSGGLVRNKDGSASLYTGVSDAEAHVIVIPDPFEEYESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTV9</accession>
    <name>A0A398CTV9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Flagellar biosynthetic protein FliP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">fliP</name>
        <name evidence="14" type="ORF">D3H35_11445</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a role in the flagellum-specific transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FliP/MopC/SpaP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03297">
        <property type="protein sequence ID" value="RIE03297"/>
        <property type="gene ID" value="D3H35_11445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005837">
        <property type="entry name" value="FliP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005838">
        <property type="entry name" value="T3SS_IM_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587">
        <property type="entry name" value="PTHR30587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587:SF0">
        <property type="entry name" value="PTHR30587:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00813">
        <property type="entry name" value="FliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00951">
        <property type="entry name" value="FLGBIOSNFLIP"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01302">
        <property type="entry name" value="TYPE3IMPPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01103">
        <property type="entry name" value="fliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01060">
        <property type="entry name" value="FLIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01061">
        <property type="entry name" value="FLIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7 12" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="11 12" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="5 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="14" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017386172" description="Flagellar biosynthetic protein FliP" evidence="13">
        <location>
            <begin position="26"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE03297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="249" mass="27430" checksum="2521D1ECB2CE0BE8" modified="2018-12-05" version="1">MKRKLIASLLFLQTAVLAFGGSAFADSPLIDISVGDGKEPVGASSLSLLLIITVLSLAPAILVLMTSFTRIVIVLGFVRTSLGTQQMPPNQVLIGLALFMTLFVMSPTLSKVNSEALQPYLKSEISQTEALQKASVPMKEFMYKHTRAKDLLLFMNYTKTEKPESYQDIPITVLVPAYAISELKTAFQMGFMIFIPFLVIDMVVASTLMAMGMMMLPPVMISLPFKILLFVLVDGWYLIVKSLLTSFQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTZ0</accession>
    <name>A0A398CTZ0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 9">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">infB</name>
        <name evidence="12" type="ORF">D3H35_11605</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8 9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03327">
        <property type="protein sequence ID" value="RIE03327"/>
        <property type="gene ID" value="D3H35_11605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="555"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="71"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="G-domain" evidence="8">
        <location>
            <begin position="558"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="78"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="412"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="564"/>
            <end position="571"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="610"/>
            <end position="614"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="664"/>
            <end position="667"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE03327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1053" mass="110839" checksum="8F22C6A4C47E79B8" modified="2018-12-05" version="1">MSKQETNDNKDKLRVYEYAKQLNMSSKEVITILKRQNMPVNNHMSVMEDGMVGAVEKFFRDVKANAAAKMAQNNKPGGAPAQGASQGQSARRPEETRANASVASTPPAQASQPAPRPAQVSSQPAAASAPAASASASAPSAPAASAATAAPSAGSEPSGQPQSSPSNGQGGGYQGNRDGNRPQGQGGGYQGNRDGNRPQGQGGYQGNRDGNRPQGQGGYQGNRDGNRPQGQGGGYQGNRPQGQGGQGGGYQGNRPQGQGGQGGGYQGNRPQGQGGQGGGYQGNRPQGQGGQGGGYQGNRPQGQGGQGGGYQGNRPQGQGGQGGGYQGSRPQGQGGYQGNRPQGQGGQGGGFGGSRPQGQGSFGGNRPQGQGGQGGGFGGGRPQGQGSQGGGFGASRGGPAPASAAAGQRGGRPGENRRDNGFNRDGGKRNQNDFGKRFEEGRPGGPRGKGKGGKNARGRSNLPPREKIDNTPKKVIVRGPMTVGELAKLLHKDASEVIKKLLMMGTMVTINQELDLDTVLLVVGEYGVEVEVKIVVEDTNFETTEENDDPDALEWRPPVVTIMGHVDHGKTTLLDAIRETKVAAGEAGGITQHIGAYQVEINEKKITFLDTPGHEAFTTMRARGAQVTDITILVVAADDGVMPQTVEAINHAKAANVPIIVAVNKIDKPDANPDKVMQELTEYGLVQEAWGGDTIFVNVSAKQRLNLDELLEMVLLVAEMNDYKAVVDKRARGTVMEAELDKGKGPVARILVQNGTLKVGDAFVAGDCFGRVRAMTNDRGRRIKEAGPSTPVEITGLTEVPQAGDPFMVFEDERKAREIADKRSIKTRQDNIKANSKVTLDDLFSKIKEGEIKDLNVILKADVQGSLEALKGSLEKIDIEGVRVRTIHSGVGAITESDILLASASAAIVIGFNVVAESRAAQAAEQEKVDVRLHQIIYKVIEEIEHAMKGMLDPVFKEKVIGHAEVRETFKVSKVGTIAGCMVTDGKIVRNAEMRLIRGGSIVYTGKIDSLKRFKDDAKEVSEGYECGITLDKFNDLQQGDVIEAFIMESVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUX5</accession>
    <name>A0A398CUX5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_19465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02814">
        <property type="protein sequence ID" value="RIE02814"/>
        <property type="gene ID" value="D3H35_19465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="300" mass="32877" checksum="BD8B35FDB6AB07E5" modified="2018-12-05" version="1">MNISQLETLLTISKTLSFRKAGELLNLTQPAVSAQIKSLEDEFKTVLVDRNHPVTLTDRGQVFLEHAESILAIVEELKQKLSDLDQNPQGHIVLGTTSSIAIQILPRVLSYFQDQFPLIKSTILSMPSTQVLASVENGSVDVGIGYLSDRNTHVETSVLYYDTFELVVAPRHPLASAGPVTISSLKDVPLIMLSPDTLGRRFADQVFRNNGIQPNIVMELSSSEEVKRMAELNLGAAIVSKLSIAGELKRGTLKMIPVSALQASHPVGVMTKSGRYLNSAMRQFLNDLKGMPEHQFVGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVZ7</accession>
    <name>A0A398CVZ7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoserine aminotransferase</fullName>
            <ecNumber evidence="6">2.6.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphohydroxythreonine aminotransferase</fullName>
            <shortName evidence="6">PSAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">serC</name>
        <name evidence="9" type="ORF">D3H35_08895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 6 7">
            <text>2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="6">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6 7">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04057">
        <property type="protein sequence ID" value="RIE04057"/>
        <property type="gene ID" value="D3H35_08895"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00611">
        <property type="entry name" value="PSAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PTHR43247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01364">
        <property type="entry name" value="serC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="6 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="8">
        <location>
            <begin position="6"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="238"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="362" mass="39067" checksum="DE6A5FD85D241E3E" modified="2018-12-05" version="1">MANRAYNFNAGPAALPLEVLQQAQEQFVEFDNTGMSLMEMSHRGAVYEKVHYETENLLRELLGIPEGYKVLFLQGGASTQFAMIPMNLLSPGKVGAYVATGSWATKAIEEAKLFGDTAIAASSEADKYARIPSLTDVKIPDNAAYLHVTSNETIEGTQWQAYPDSGSVPLIGDLSSDILCRPIDVSRFGLIYAGAQKNLGPSGVTIAVIREDLIGKPSMTVPTMLRYSTHAKADSLYNTPPTFAIYMVNTVLKWVKANGGAAGMAARNGEKAKLLYDAIDGSGGFYRGFAESASRSIMNVTFRMGSEELEKQFAKESEANGFVGLKGHRSVGGLRASIYNAVPPESVQALVSFMKDFQSRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXG4</accession>
    <name>A0A398CXG4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_08065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03911">
        <property type="protein sequence ID" value="RIE03911"/>
        <property type="gene ID" value="D3H35_08065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005690">
        <property type="entry name" value="GerBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="458" mass="51187" checksum="5BB4A5CBB2FE8E84" modified="2018-12-05" version="1">MAACGQPNGNRRNGGFHLLNRLVAELNDPDDLCSETIDNGYWTMELVYFPALCDEAFIKDGLLVPFSYRFDPDEFRRMLKANPKFVKQDDRSDLKKHVLQGKVILSLEGTVYSFDAIRKLITKPDTAQVETALQGPYSALAEDLDINLYLIRSSYNDSSLAIEYRRLGDISNTRISLVYDKKLVNESVRKELDRRLSAADLKLVQAAGELGKKIAGSKRPLFPLTLVTERPDRITMLLKRGKIVIVIDGSRFALVLPVCFSDFMHAMDDEYEMFWMSRALLLLRYLSLFLTLTLPAAYISIVSYNPEIFRVQLTLSIAGSRLVVPYPSFIEVFIMLFMIEALTEASLRLPRYIGSTAATVGGLILGQAVQQAGLVSSIMIIVTSVVAISNFVIPNSTFSYAIRFAKYIFVAAAIFFGTVGVVVTFFMLVVYVSGLRSFGEPYLTLPLAKNKGFKQKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXL6</accession>
    <name>A0A398CXL6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_05855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000026">
        <property type="protein sequence ID" value="RIE04527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04527">
        <property type="protein sequence ID" value="RIE04527"/>
        <property type="gene ID" value="D3H35_05855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="82" mass="9043" checksum="27BFECF23ED1071C" modified="2018-12-05" version="1">MRSFHLFDGLLHRLVAILRVLGRLLSDGCHRSRPISDRPDAVANLNRDFGASLHSFRWESAPAASSRIESAIWSAPDAACSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXX4</accession>
    <name>A0A398CXX4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05388">
        <property type="protein sequence ID" value="RIE05388"/>
        <property type="gene ID" value="D3H35_00970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="92" mass="10483" checksum="F41CF3D4546215EE" modified="2018-12-05" version="1">MLRYSGNRMLVGSDGDIQEIEQNAPIWPAAICVLWPTYVYRRSPLRAYAAADLYRYARIDVAAVLLRRPVLDETQPFVQPRRPALFFAPASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY69</accession>
    <name>A0A398CY69_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsT</name>
        <name evidence="9" type="ORF">D3H35_05975</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04171">
        <property type="protein sequence ID" value="RIE04171"/>
        <property type="gene ID" value="D3H35_05975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="90" mass="9672" checksum="7F60B51309F775EE" modified="2018-12-05" version="1">MPNIKSAIKRTKTNEKRRLRNASQKSALRTAVKAADQAVVGTDVNAAKDALVLAQKKLDKAVTKGLIHKNAAARKKSRLAKKLNALSAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYD3</accession>
    <name>A0A398CYD3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04817">
        <property type="protein sequence ID" value="RIE04817"/>
        <property type="gene ID" value="D3H35_04935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="PTHR13355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="148" mass="16945" checksum="600AB224CCEC94C7" modified="2018-12-05" version="1">MECKRIDTEDELKQAFAIRMEVFVDEQGVPESEEMDEYDVLSAPCTHFLLWQDGVPIATGRWREYDDRPGAVKIQRFAVRARYRGTGAGRVLMEGMERDARTRGFTQAVLDAQCTAEPFYLKLGYVTESEEAFLDAGILHVRMSRSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYV6</accession>
    <name>A0A398CYV6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rplQ</name>
        <name evidence="6" type="ORF">D3H35_02385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05017">
        <property type="protein sequence ID" value="RIE05017"/>
        <property type="gene ID" value="D3H35_02385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE05017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="121" mass="13854" checksum="A7F324331347504A" modified="2018-12-05" version="1">MAYQKLSRDSSSRKALFRDLVTDLFLYERIQTTQAKAKEVRSIAEKLITLAKRGDLHARRQVAAFVRRETIDGNQDAIQKLFSELAPRYAERPGGYTRILKLGPRRGDSAPMVYLELVDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ70</accession>
    <name>A0A398CZ70_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3907 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_06290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04224">
        <property type="protein sequence ID" value="RIE04224"/>
        <property type="gene ID" value="D3H35_06290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025013">
        <property type="entry name" value="DUF3907"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13047">
        <property type="entry name" value="DUF3907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="166" mass="19290" checksum="604C1D4D2DBBB343" modified="2018-12-05" version="1">MPATNVKGLAESSREKLKIAIAQLEQFLNGHALPQLVQEDKAESENFYSGLLSDLRHLLVFSEVAYEKLGALLRRPNFDLELAERALYEVYHHGVNAFFYPKNECYSEDGRYAYTGQDAIRFRQKPVRAARDIVLNVSRLYEELRDDLSYYESDYLTQRRMQGQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0Q7</accession>
    <name>A0A398D0Q7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Outer spore coat protein CotE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cotE</name>
        <name evidence="1" type="ORF">D3H35_04545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04754">
        <property type="protein sequence ID" value="RIE04754"/>
        <property type="gene ID" value="D3H35_04545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018901">
        <property type="entry name" value="Spore_coat_CotE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10628">
        <property type="entry name" value="CotE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="186" mass="20484" checksum="4040ECCA366F331F" modified="2018-12-05" version="1">MAIADKRLQAREIITKAVCGKGRKFSTITHTVTPPHHPSSILGAWIINHQYEAVRSGDGIEVIGSYDVNIWYSYNKNSQTDVAKETLSYVELVPLSYVDPKHRSSTEEVSADATQEPNCVEATISSGGSSVLIRVEREFAVEMVAETKVFVAVYPGGVDDDKDQDFGLVDDGDYENLDADLLEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0W7</accession>
    <name>A0A398D0W7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04814">
        <property type="protein sequence ID" value="RIE04814"/>
        <property type="gene ID" value="D3H35_04920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="87" mass="9574" checksum="E0607B2AA9A55BFF" modified="2018-12-05" version="1">MRTASALCLLADMFGVRSNKHRGAFIALIIFLVLFVNVYPTGDSLQYFLVSWYTPSMLPIALLLSMYLFLLAVVSRKGGKSNAQNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D171</accession>
    <name>A0A398D171_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2306 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05241">
        <property type="protein sequence ID" value="RIE05241"/>
        <property type="gene ID" value="D3H35_01595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018750">
        <property type="entry name" value="DUF2306_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10067">
        <property type="entry name" value="DUF2306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="209" mass="23846" checksum="3749A62BDF09B35A" modified="2018-12-05" version="1">MEKRKIAYLLLSVVCTILIVYALANNYVLDPGREHFLSSKTGLQRELNVSVWLKVMYIHVAFACLAMASGLLNFSKHTLDSHRKLHRVNGYIYLFSVLIVLLTSGYMAPYATGNQISSIGFNVLNLTWLFTTITAFVHIKRKRITLHRAWMVRSYAFCFNNMLIHLFTAILHDGFGLGYTSSYTIGIYGSIATIVTVPTLINRRQRFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D306</accession>
    <name>A0A398D306_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Efflux RND transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000002">
        <property type="protein sequence ID" value="RIE05474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05474">
        <property type="protein sequence ID" value="RIE05474"/>
        <property type="gene ID" value="D3H35_00150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="84" mass="8926" checksum="13EF1C6644969924" modified="2018-12-05" version="1">MTGDNLDQLTKSADEVIAKIKPIKDVLKVESNQEEKKTVYTLKVNASQAKAGDIASQLQGMLNSVPIGTMKANGSLSALFSSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBL6</accession>
    <name>A0A398CBL6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00173">
        <property type="protein sequence ID" value="RIE00173"/>
        <property type="gene ID" value="D3H35_29465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="69" mass="8243" checksum="AFED827BB049A266" modified="2018-12-05" version="1" fragment="single">MKSAAIWRRWRDRATMWSPRPTFRDVAQPVPEGIRPEALPYPFREDERIAAAFDSKLDDDELDFNQLMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBU9</accession>
    <name>A0A398CBU9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_29935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00253">
        <property type="protein sequence ID" value="RIE00253"/>
        <property type="gene ID" value="D3H35_29935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011152">
        <property type="entry name" value="Pesterase_MJ0912"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000883">
        <property type="entry name" value="Pesterase_MJ0912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="2">
        <location>
            <begin position="4"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="244" mass="27487" checksum="A38AA8A775EA7D1C" modified="2018-12-05" version="1">MDTIAIISDVHGNIPALEAVLNDISRRKITRIFCLGDLVGKGPDSVAVVDIVKERCERIVMGNWDDLVTKPNDHEEVSWHRNILGVDRLNFLRSLPFSIEFFMSGKFIRLFHASPRSLYERIQPWDALEKRLSLCQSSVFCLEDREADVIGYGDIHNAYLQHSNGKVLFNVGSVGNPLDSVDASYAIVEGAMDEERSSAPFELRFIKVPYDIEMAVRLAVAAKVPSSEAYIKELRTGKYRGLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBV6</accession>
    <name>A0A398CBV6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00260">
        <property type="protein sequence ID" value="RIE00260"/>
        <property type="gene ID" value="D3H35_29975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="279" mass="31310" checksum="439F4942BB60E12C" modified="2018-12-05" version="1">MKKIGFIDYFLDEWHADNYPTWIEQATGGEMKVAYAYGMKDAENGLDNASWCRSKGIELLDSIEAVVDKSDYLIVLSPDHPERHEELATLPLQSGKPTYVDKTFAPDRKTAQRLFQLAREHGTPVFSSSALRFASEYVGADREGIRAICSIGPGKYDNYSVHQIEPIVSMMGVEAERVMYVGTEKSPEWIIGFSGGRQATIHFFKNSPFFLALNEEADSSRFLKVESDFFAAFIKSMVQFFETGKPPVEPIETIAIVSIIEYGHLAAAAPYQWVELPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCI9</accession>
    <name>A0A398CCI9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_28955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00440">
        <property type="protein sequence ID" value="RIE00440"/>
        <property type="gene ID" value="D3H35_28955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="71"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="267" mass="29351" checksum="4886F0C593341919" modified="2018-12-05" version="1">MIGKFNLFASGKRSSVGKKVVLGSVIPILIVSVWQYLSSNGIVDAILFPAPSTILNSFYEMIVSGELIDHLKISVVRAMLGFLLGGSLGLLAGLVVGMFVRAEELLDPTMQMLRTIPLLALTPLFILWFGLGETSKVLLIAFGAFFPLYVNAFLGVRNVDAKLFDVAKVLEFNRFRQITRLVLPAAMPNVLLGLRLSLSVSWLLLVVAELMGASRGVGFLIQDARTFVRTDVVFIGIFLFAAAGKLTDSLVRMLEHWLLKWQDSYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCT4</accession>
    <name>A0A398CCT4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cysteine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00513">
        <property type="protein sequence ID" value="RIE00513"/>
        <property type="gene ID" value="D3H35_27595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16332">
        <property type="entry name" value="Prp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007422">
        <property type="entry name" value="Peptidase_Prp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036764">
        <property type="entry name" value="Peptidase_Prp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39178">
        <property type="entry name" value="PTHR39178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04327">
        <property type="entry name" value="Peptidase_Prp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118010">
        <property type="entry name" value="SSF118010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="109" mass="11826" checksum="37DC6005C608E2AB" modified="2018-12-05" version="1">MITVTIVRSAEGRIRRFSIAGHANYDKIGKDIVCAGVSAVTVGAVNAIEKLTGFVPEATIRSGWLTAQFPICEEAAREANVQLLLEGMVVALETIVDEYGKYVRIQQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD01</accession>
    <name>A0A398CD01_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000060">
        <property type="protein sequence ID" value="RIE00295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00295">
        <property type="protein sequence ID" value="RIE00295"/>
        <property type="gene ID" value="D3H35_29315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="17"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="105" mass="11975" checksum="BDC0E8C788031849" modified="2018-12-05" version="1">MEVRRGSLVSPNGERTSTLSINGMVLGGQLQLTIDYNGKAYEADTIEELAAGYKRHLEAIIEHCADRRETEKTPSDLSFKQLTIQELEEFEEEMEWLTILDSERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD66</accession>
    <name>A0A398CD66_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SRPBCC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01126">
        <property type="protein sequence ID" value="RIE01126"/>
        <property type="gene ID" value="D3H35_22175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="176" mass="20094" checksum="0591BEFF8C8C539B" modified="2018-12-05" version="1">MNENISAEENAAELLITRSVNAPRELVFKVCTEPEHLSRWWGPKGFDMHVSKLELRPGGVFHYSQRSPEGQVMWGKFVYREITAPERLLFTSAFSDEEGNTVRAPFSATWPLEILNDWQFFESDGKTTMTMRGTPVSPTDDELATFKNAKSMLQQGFAGTFQQLENYLFELTEGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDM9</accession>
    <name>A0A398CDM9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0756 membrane protein D3H35_26460</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0756 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00740">
        <property type="protein sequence ID" value="RIE00740"/>
        <property type="gene ID" value="D3H35_26460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01874">
        <property type="entry name" value="UPF0756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007382">
        <property type="entry name" value="UPF0756_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38452">
        <property type="entry name" value="PTHR38452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04284">
        <property type="entry name" value="DUF441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="152" mass="15906" checksum="EA5A29A1BE608705" modified="2018-12-05" version="1">MNGEIVLVALIVIGLAARSPIITTAACLLLIVKLVHLQRYLPAIERRGLELGLLFLTLAVLSPFASGKMQAKDVIAAFSGWTGWVALAGGALAAYLNSRGLELLKVDPQMIVGLVIGSIIGIVFLRGIPVGPLMAAGLTAMLIKIVQLIVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEG3</accession>
    <name>A0A398CEG3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01093">
        <property type="protein sequence ID" value="RIE01093"/>
        <property type="gene ID" value="D3H35_21985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024307">
        <property type="entry name" value="YmaF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12788">
        <property type="entry name" value="YmaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="120" mass="13474" checksum="9F89EC1444370C51" modified="2018-12-05" version="1">MPIRKPKIKRIAASSVRVQRHVHEFEGSTKLAEQGADRHNHRFAGVTGQAIRVGNSHVHEIDLSRTDFLNHFHNLRRIRTGPAISVGNGKHVHFVTGQTTLNDGHVHRFNFATLIQAPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEH8</accession>
    <name>A0A398CEH8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4405 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_24835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01576">
        <property type="protein sequence ID" value="RIE01576"/>
        <property type="gene ID" value="D3H35_24835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025517">
        <property type="entry name" value="DUF4405"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14358">
        <property type="entry name" value="DUF4405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4405" evidence="2">
        <location>
            <begin position="78"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="191" mass="21613" checksum="2ADD94F04E16B2EC" modified="2018-12-05" version="1">MKKINDVKLALDVVMGVLFVLFFNKNVLGGLAFHEIAGLFFAGAYVTHILLNLGWVKRVTLKMFDRRLSWRVRGSYALNFLLLVSMTFIIVSGIMVSHVVFPNINVGDEGWFKMTHISVSFLVLALIGIHVGLHWQWVVNMCKKMTSVKKSRAWMRYVAQGVTLIVLLFGLYQINQTSYVTHLKSSVSAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEQ9</accession>
    <name>A0A398CEQ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4367 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_22090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01110">
        <property type="protein sequence ID" value="RIE01110"/>
        <property type="gene ID" value="D3H35_22090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025377">
        <property type="entry name" value="DUF4367"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14285">
        <property type="entry name" value="DUF4367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4367" evidence="2">
        <location>
            <begin position="141"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="254" mass="28424" checksum="7A077C9885CF9D32" modified="2018-12-05" version="1">MMNELEEDRLIQQAMQTVHADVEIPDPTKSWNNVQNKIQRLHQAKKRRKRLKIVVGVVALTCLIEISIQASILKSYANVSTLFREVKQNVIEIFFEPSPKQDTSAAKTSPPPSAEIDVPAVPEEVPLSDALEKLAFDLLLPSYLPQGFELGAVRIFREADGLYKNVYLEYETASGEIFKLSERIVEPKTASIKSDIASEAGAINNYIVNGNEAVLVVMPDNFVDMEWLTKSHIKISISGKLAEEEIVLFARSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEZ1</accession>
    <name>A0A398CEZ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_29035</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00452">
        <property type="protein sequence ID" value="RIE00452"/>
        <property type="gene ID" value="D3H35_29035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="333"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="366"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE00452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="571" mass="64350" checksum="3C3E0A53467C4E00" modified="2018-12-05" version="1">MIRRFFAYYQPYKRLFMLDFGCAVFAGLMELAFPLVVNRFVDDLLPGGKWDLIVWASAGLLALYVLNMFLQYIVNYWGHMLGINIETDMRRKLFEHVQKLSFRFFDNTKTGHLISRLTNDMMQIGEMAHHGPEDLFIAVMTLAGSFTLMLFINWKLAILTFIVVPAIIGLVVYFNGKMTKAVEQLFSDIGDFNARIEDNVGGIRVVQAFSNEEHEKKQFDVNNSRFRATKLLSYKLIAKNGSISYMMMRFVTLFVMVCGTWFVIQKELTYGQFIGFLLLSNVFFRPIEKINAIIESYPQGIAGFKRYAALLDTEPDVADTPDAKVIGELQKEIKFDKVSFGYDRGSSVLNDIDLTIRKGETVAFVGPSGAGKTTLCSLLPRFYEVDAGTVSIDGFDIRQAKLSSLRKQIGIVQQDVFLFSGTIRENILYGNLNATEEQIWEAARRARLDDFIRAQPDGLDTVIGERGVKLSGGQKQRMSIARMFLKNPPILILDEATSALDTETETIIQQSLAELSKGRTTLVIAHRLATIKNADRIVVVTEDGIAEQGDHQELIAADGVYSRLHRAQFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGC1</accession>
    <name>A0A398CGC1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">7-carboxy-7-deazaguanine synthase</fullName>
            <shortName evidence="5">CDG synthase</shortName>
            <ecNumber evidence="5">4.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">queE</name>
        <name evidence="7" type="ORF">D3H35_24435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-deazaguanine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:27974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="EC" id="4.3.99.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </cofactor>
        <text evidence="5">Binds 1 S-adenosyl-L-methionine per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.99.3" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01505">
        <property type="protein sequence ID" value="RIE01505"/>
        <property type="gene ID" value="D3H35_24435"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016840">
        <property type="term" value="F:carbon-nitrogen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00917">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024924">
        <property type="entry name" value="7-CO-7-deazaguanine_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017742">
        <property type="entry name" value="Deazaguanine_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000370">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00300">
        <property type="entry name" value="7-carboxy-7-deazaguanine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03365">
        <property type="entry name" value="Bsubt_queE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="29"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="23"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="48"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="136"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="250" mass="27817" checksum="C7005DBCC21F2D40" modified="2018-12-05" version="1">MGRGKRMSSELRFPVIEVFGPTVQGEGMVIGRKTMFVRTAGCDYSCAWCDSAFTWDGSGKEQIRMLTAEEVAAELRASAGEAAFSHVTISGGNPALLGRLEALIERLHADGMQVALETQGSRWQEWFAQIDDLTLSPKPPSSGMSTDWDVLDEIVGKLQACGSSFSLKVVVFDETDLRYAAKVHGRYPGVPFFLQSGNDDVREPDTARLLERLVQRYEWLVGEVTMSKEWTDVRVLPQLHAWLWGNKRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGE4</accession>
    <name>A0A398CGE4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10 12">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="5 10 12">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">hisA</name>
        <name evidence="13" type="ORF">D3H35_21460</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10 12">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 11">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="5 10 12"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01022">
        <property type="protein sequence ID" value="RIE01022"/>
        <property type="gene ID" value="D3H35_21460"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006063">
        <property type="entry name" value="HisA_bact_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="Isoase_HisA-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00007">
        <property type="entry name" value="TIGR00007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="9 10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE01022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="245" mass="25711" checksum="20FF1D152BDA3E5D" modified="2018-12-05" version="1">MSNFIIYPAIDIRGGKAVRLVQGDYNQETVYNDDPVSAARDWEAQGGKWIHLVDLDGAKAGHPVNDELIGRIAKAVNVPVQVGGGLRKEEDVERLIGLGVSRVILGTAAIEDRAFVSRVLAKYGAQVAIGIDARNGLVATRGWLETSEVKAEDLAVQLAGEGAQTFIFTDISRDGMMGGPNVEAIVNLAKVSGRSVIASGGVSKPEDLDRLAVHAKDGVGGAIVGKALYTGSIDLAEAVRKTAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGK2</accession>
    <name>A0A398CGK2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="7">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purC</name>
        <name evidence="9" type="ORF">D3H35_16650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02346">
        <property type="protein sequence ID" value="RIE02346"/>
        <property type="gene ID" value="D3H35_16650"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="8">
        <location>
            <begin position="18"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="297" mass="33408" checksum="E09491BD443EF8B1" modified="2018-12-05" version="1">MATEALSTAEGLVNAPLIHKGKVRELYDLGDQLLIVVTDRISAFDYVLDPAVPDKGRVLNGLSAYWFEQTAALQENHVIHTDAYKLGDLVTAPEKLEGRIMVTRKAKRIDIECVVRGYITGGGWRQYQTNGEVNGIKLPEGLRKNGKLEQPIFTPAGKNDIGHDEDIPFEEMARRVGAELSEALRDRSLKLYAFGRDFCAERGIILADCKFEFGLIGDDIILIDELFTPDSSRFWAEEKYALDIEIDSMDKEPVRAYLANSDWDKNSPPPRLPDEVVETTSARYKDIYRRLAGDRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGK6</accession>
    <name>A0A398CGK6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01873">
        <property type="protein sequence ID" value="RIE01873"/>
        <property type="gene ID" value="D3H35_13895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="208" mass="23098" checksum="34724DD3B37BF25A" modified="2018-12-05" version="1">MQLWLRLLLVAVIIFCASSFVWFLLGSTAYFQRSMDIIGTTAFWGAAVPVLLFVGLFIILLIKGWKPTSGGQYAAISIGLLVSILLSVVLIQSVSTNGWANEKIESDSVKVTADKKYEYRIELISLFQKNGHARLYLKDSGSGTETYIPVDIQTRKIVGLGVKKVNHWVMLEPTDTESEYILYTTKELGIPEEKFKIDIIAGTSNGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGR2</accession>
    <name>A0A398CGR2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_21680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01645">
        <property type="protein sequence ID" value="RIE01645"/>
        <property type="gene ID" value="D3H35_21680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07477">
        <property type="entry name" value="Peptidases_S8_Subtilisin_subset"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034202">
        <property type="entry name" value="Subtilisin_Carlsberg-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="121"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="377" mass="41336" checksum="6CC6F56CF8123368" modified="2018-12-05" version="1">MRRIADWLQHSLAANERRHSRKILRFTNPGDYRSFLEEWVRRLPGIDSPTPVRALGLIQALACPIPEGDSPPSPGDRIICEEDEKVAIAGLPKGEITSDKGIPWGVRRIKAPEAWSRTTGHRIRVGVIDTGVDFQHPDLAHSLERGINLLQRSMLPQDDNGHGTHIAGTIAAANQYYGMMGVAPRASVHPIKAFDNNGTAYVSDIVLGIDWCVRNHIDVVNMSFGMRTRSKSLLNAVAGAYRSGVLIVASSGNDGRKEEIDYPARYHQSVAVGAINRQGRIAAFTNRSPLIDIYAPGERISSAWIRGKHRIMSGTSMATSHVTGAVALLLSYRPGLSPAQIKAILKQSAKPLKYGKAPRLAGELDISRMLHIAERDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGV6</accession>
    <name>A0A398CGV6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_22605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01192">
        <property type="protein sequence ID" value="RIE01192"/>
        <property type="gene ID" value="D3H35_22605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="195"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="325" mass="37321" checksum="958B8B9DBD209CDF" modified="2018-12-05" version="1">MDTQLDFAPCGYFSISSKGIIQSVNQTLLNMLGYDRNGMLDRHIESFLSVTNKLFFHTYFYPFIQLYGQVSELYLSLKASSQLDVPVLLNGVRQERNGEIFIDCVVVEMRKRLEHEKDILQTKKRLEELYQATNEANKKLELLHQEYEIKQQELMNVNHQLETIALTDPLTGLKNRRFLQESLLTNIALFQRTQLSFSLLIFDIDHFKSINDTYGHPVGDLVLIKLAQLLKAEAREIDIVARYGGEEFILILPNTTQEDSSRIAERYRSKIEATPMGEYRITTSIGAATITQEDSDQTLLQKADQALYYSKANGRNRVTHAIALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH59</accession>
    <name>A0A398CH59_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pcrA</name>
        <name evidence="10" type="ORF">D3H35_29900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00248">
        <property type="protein sequence ID" value="RIE00248"/>
        <property type="gene ID" value="D3H35_29900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005751">
        <property type="entry name" value="ATP-dep_DNA_helicase_PcrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01073">
        <property type="entry name" value="pcrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="19"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="9">
        <location>
            <begin position="299"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="682"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE00248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="786" mass="87106" checksum="D9B783E10AAC46E0" modified="2018-12-05" version="1">MFFEPVHQSGAVDIDKAISKLNPRQKQAAESVQGPLLIMAGAGSGKTRVLTHRIAYMIAKRMAAPWSILAITFTNKAAREMRERVEKLVGPSASDIWVSTFHSMCVRILRKDIERIGYGSNFTILDSTDQLSVIRNVMKDQNIDTKKIEPKSVQAAISGAKNELLSPEIYEQRQGDYFQSIVARVYTQYQKRLKSNNALDFDDIIMLSIRLFKEVPEVLDYYQNKFRFIHVDEYQDTNRAQYMLCRMLADKHHNICVVGDSDQSIYRWRGADITNILNFEKDYPEAKTVLLEQNYRSTSNILEAANAVIKNNLGRKAKNLWTDQTGGDKIVVYQGDSEHEEGYFVAGEIRKNRANGRKFGDHAILYRTNAQSRVVEEILIKSEIPYQIVGGIKFYDRKEIKDILGYLRLISNPDDDISLNRIVNVPKRGIGDTTMARVQEQAGQWGISMYRALTESLHELDIQARAKAALGEFRDQVASLTAMVDYLSVTELTEKMLEMTGYRIELQREKTLESQSRLENIDEFLSVTQEFEKRNDDKSLVSFLTDLALIADIDSMNSAEEEDGGDAVVLMTMHSAKGLEFPVVFIVGMEEGVFPSSRAFMDNEELEEERRLAYVGITRAEKKLYLSCARMRLLYGRTSSNAPSRFLGEIPEQLKESNGNMSGRSGSFGGFASRVGGSGGTSGTVGGFGSRGTTGGFGARPSASGSGMAPAPAARASVTQTPAVKPAGSGEGLTVAAGDKVQHAKWGIGTVVAVKGTGNDMELQIAFPAPIGVKRLLAAFAPVTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHE7</accession>
    <name>A0A398CHE7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000053">
        <property type="protein sequence ID" value="RIE00509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00509">
        <property type="protein sequence ID" value="RIE00509"/>
        <property type="gene ID" value="D3H35_28110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="71" mass="8361" checksum="C090CAA0CF01CCCC" modified="2018-12-05" version="1">MEREECERNPYRERNAGQTALQGFRRNERLYESPRSFPFEPAFAAGLRRDGCSRYPAQAPNGSREWKPVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHR2</accession>
    <name>A0A398CHR2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Low molecular weight protein arginine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_14515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01980">
        <property type="protein sequence ID" value="RIE01980"/>
        <property type="gene ID" value="D3H35_14515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="5">
        <location>
            <begin position="2"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="194" mass="21537" checksum="213E4483926CC1D3" modified="2018-12-05" version="1">MKRILLVCTGNTCRSPMAEAMLRKMADRAGKKLEVRSAGVSTIGGLPTSPHATETLKRRGIPLPGPSSTLSESETEWANLILTMTSGHKRAIVQRHPEAMNKTFTLKEYALLGEAVMDDLAEAERLYSEWQVRQALGQQLSEKDRSRLMELQSKLPDFDIADPFGGPLYVYEQCADEIEEALRAILGKMDANDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHR5</accession>
    <name>A0A398CHR5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage tail protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00669">
        <property type="protein sequence ID" value="RIE00669"/>
        <property type="gene ID" value="D3H35_27290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011083">
        <property type="entry name" value="Phage_tail_collar_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037053">
        <property type="entry name" value="Phage_tail_collar_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07484">
        <property type="entry name" value="Collar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Collar" evidence="1">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="169" mass="17570" checksum="193936AB1409C15E" modified="2018-12-05" version="1">MAEPFLGEVRLLAFNYPPQGWVQCNGQLLSISQNQALFTLLGNSYGGDGKTTFAVPNLQGSVPVQTNNASVVGAAGGEAAHTLTINEMPAHTHEATGGADATSATPLGNAWGTQSAAPAVTSYEPTANTTMNSNALQSMGASQPHSNMQPYLVINYCIAVEGYYPPKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHW3</accession>
    <name>A0A398CHW3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Anion permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_16855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02383">
        <property type="protein sequence ID" value="RIE02383"/>
        <property type="gene ID" value="D3H35_16855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="335" mass="35308" checksum="AFE4D6FA38CFA06B" modified="2018-12-05" version="1">MDSTMILVVIIVALALGFDFINGFHDTANAIATSVSTRALTPRRAIILAAVMNLVGALMFTGVAKTIGKDIVDPFKMGEHGLTIVIATLVAAIVWNLLTWLWGIPSSSSHALIGALAGAGIASQGWDGINYGGFSKIVLGLVMSPIIAFVIGYIIMFILKHVFANTSPHHVNKVFRSGQVLTAALQSFTHGTNDAQKAMGIITMALVVGELHPDMDSIPFWVKLSAALAMAAGTSIGGWKIIKTMGTKIFKIEPINGFSADIASASIILTATLAHLPVSTTHTITSSILGVGAAKRFSSVKWHVAGRIIVTWIITIPVVAILSAAVYGVLSLFMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI72</accession>
    <name>A0A398CI72_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ComF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02055">
        <property type="protein sequence ID" value="RIE02055"/>
        <property type="gene ID" value="D3H35_14925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="270" mass="31037" checksum="E579CCF1B1F4161C" modified="2018-12-05" version="1">MLGWVHIGKWFRPAAEPCLLCGQWLRSSPSERRSVPVRMEQPRRVLMQLCDACMASIPWIRRPICLTCGRAEACGDCARRRETHFVRSRSAVRYDASMKAWLALYKYRGHERLELLLSAMLAFAFERMCLERGVSVRQASSYFHAVVSVPLADERLEERGFNQADRMASALARWYGLKHEHLLSRLHHTEKQSLKSRRSRMLDMQGNFALSASSGRLAVLRSSELRRIVLIDDIFTTGSTMNECARVLRMARPSFAESDIQVYGVLWARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIE6</accession>
    <name>A0A398CIE6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Trk family potassium uptake protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_20955</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03056">
        <property type="protein sequence ID" value="RIE03056"/>
        <property type="gene ID" value="D3H35_20955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004772">
        <property type="entry name" value="TrkH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00933">
        <property type="entry name" value="2a38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="448" mass="48869" checksum="DF2D4DF937AB8BB4" modified="2018-12-05" version="1">MLFLLIRSFLSQRSPQQVLVVGFLLLIVVGSILLWLPVSSRDGHDISFHDALFTATSAVCVTGLTVVPTGQTFSLFGQIVMMILVQMGGIGFMTMTTWFALALGKRISLKERLIIKESLNQANTEGIVRLIRKVVLYSLVVESAAALLFALRWYSEMGPAKALYYGLFHSVSIFNNAGFDLFGGLGAYVNDVPFNIVSIVLILLGGVGFIVMSDLIDYRRTRRFSLHTKVVLVFSGLLFAFGGFVIFLFEYTNPVTFGQLGDGSKLLSAFFHSASLRSSGTSTVDISSMRQATQFFMIIVMFIGAAPGSTGGGIKITTFAVLLAAVWTLLRGREDVVLFRNRLSKDLVYKAVTFTMVGLALVIVPTMILSVTESGSFLSILFDTVSAYGTVGHSMGVANEDLSGFGKTLLVILMFVGRLGPVTLAYALHNKKQRKTLFRYPEGKIIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIG4</accession>
    <name>A0A398CIG4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02165">
        <property type="protein sequence ID" value="RIE02165"/>
        <property type="gene ID" value="D3H35_15570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="107" mass="11981" checksum="3A1874E42E0BDC69" modified="2018-12-05" version="1">MARFGRASGDVWDEVPPLARFDRTSGVVWDEVPPLARFGRASGDVWDEVPLLARFGRISGDVWDEVPLLARFGRISGDVWDEVPPLARFDRTSGDVWDEVPPLARFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIR1</accession>
    <name>A0A398CIR1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_18245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02623">
        <property type="protein sequence ID" value="RIE02623"/>
        <property type="gene ID" value="D3H35_18245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="3">
        <location>
            <begin position="8"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="337" mass="38321" checksum="24F2DDAB0558A6AC" modified="2018-12-05" version="1">MSKGCFLSVVVPMYNEEEVIETTYRRLSDVLESLGETYEIIFVNDGSRDRTADIVHGICASDSRVKLVDFSRNFGHQIAVTAGMDYSSGRTVVLIDADLQDPPEIIKDMVERWREGYDVVYGKRIARKGETWFKKTTAAMFYRLLRSMTSVNIPVDTGDFRLMDRKVCDALCEMRERSRFIRGMVSWAGFRQASVEYVREERFAGETKYPLRKMIKLSLDAITSFSTKPLKFAGILGFLLSAAGFIYLLIVLYQRLFTETTQKGWTSLIIISLFFHGITLSLLGVLGEYIGRTYEESKRRPLYLVSEKVNFESGAVADRAEETRAKSDPKPVLTAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIR7</accession>
    <name>A0A398CIR7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03186">
        <property type="protein sequence ID" value="RIE03186"/>
        <property type="gene ID" value="D3H35_18375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="311" mass="35811" checksum="9500CDFC366A1F38" modified="2018-12-05" version="1">MAPLQGIFLLTALFFLLFVCFRIGIRAWLDRAALARRLHANRNKAIHRATVIPRTRFIRLHSHISDLLAAIGWSMRTDAFVTLSFCLGVTGATLGMLFFQSFRSSALLAAVLALFPYALLWMRLVSRQTAARLEFLPAVELFYQCYLVSGCRHVRTAVQRTVEERRLTSEVQTIFEQLYRNLSVQEDDEASLRRFVLSFGHEWADYFGNVLKVSLAEGNNVAHNLQELIADMRKAQLTDHQERHRLLEIRLANFSPILFLVLFLVINFRMNPESSYRYYVLDPAGRAMILNAVVLLFGSFLMGLYLSRRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIY0</accession>
    <name>A0A398CIY0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_22395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01159">
        <property type="protein sequence ID" value="RIE01159"/>
        <property type="gene ID" value="D3H35_22395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02857">
        <property type="entry name" value="E_set_CDase_PDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004185">
        <property type="entry name" value="Glyco_hydro_13_lg-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02903">
        <property type="entry name" value="Alpha-amylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="135"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="602" mass="69626" checksum="3FA9BC71B1D345D0" modified="2018-12-05" version="1">MFLEAYYHRPKLNWAYALDETTIQLRIRTKRDDVDAVRIFHGDKCLPWSAMTEAPMTRIVSDERYDYWETEVRPPYRRLCYGFILCKGEERRWATENGFSEGAPTQHLGLYEYPVLHPEDVFKIPAWVKDAVFYQVFVDRFANGDPAIDPPNVQPWGGRPEYDNFFGGDLQGVWDKLDHLSELGVTAIYFNPLFDAPANHKYDTRDYLKVDPHFGSNDLLKRLVQACHDRGIRVMLDAVFNHSGQTFRPFVDVLEKGAESRYADWFLVRKWPLRVAKNGIPTYETFAFEPTMPKLNTANPEVRSYLLDVARYWIEEIGADGWRLDVANEVDHSFWREFRKVVKQANPEAYILGEVWHDSIMWLQGDQFDGVMNYPFANAVLDFFVFGHHDARRFADRVSELLVRYPKQALEASFNHLGTHDTVRLLTLCKGDKRIMRLAVLFQFTFAGVPCIYYGDEIGMDGEFDPDNRRCMEWDHSRQDRELFIFHRDVIALRKKYSSLRSGAFNFLRAEERDTLLAYERSDGSERIVVLMNPDEDTREIAVPLSGGRWSDAFTGQAVDVSGGICKVRLDPYGFQVIAATRAEADVQAVDGNEKANKEGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIZ6</accession>
    <name>A0A398CIZ6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IucA/IucC family siderophore biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_22525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IucA/IucC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01179">
        <property type="protein sequence ID" value="RIE01179"/>
        <property type="gene ID" value="D3H35_22525"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="PTHR34384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IucA_IucC" evidence="4">
        <location>
            <begin position="165"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="FhuF" evidence="5">
        <location>
            <begin position="437"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="589"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="614" mass="69623" checksum="A694525A0CA20745" modified="2018-12-05" version="1">MNRAITQSRPRAAERQIMKDLMDAFIAERFFAIDDQTTIKLSAAPDLAQRLYPEYEQAWLYVGDICFLLQESYRQGHQWVSDSPIYIRVNGDWTKTRSPRELSQIVLRGALSETAYAHPGVADFLEGLDIAIRQLDRSLERAEAYRSFAPKSAYDWYVKGEMISSLRDRPFHPLSKAKIGFTERDYENYMAEFGKTTALHWVAIDNDSVVKGCPEAAIQALDVLNDGQRAIIEKELAEKAISKDKYTIIPVHPWQLENIILPDFKKEVEEQTVIVLDSMAGDFLATSSVRSLTSSDASTTMLKLPISVKSLGAARYLPVVKLLNGLVGEKMFRQAVACDETLADKVFLCEEKNWWGYMPSTMGLFDDHPRHLAAQVRVYPREIMEEGYKIIPMSSLGVVERETHFLSEILGEDLSGEDVIRFYTDLAAMFYDVTMRLFKVGIVPEIHGQNCCVVLKDDKVVGLLFRDHDSVRLHQPYLDKHRIQDPGYHIRPGYSNSLYNETLEKLIFYVQSLGTQVNLASITEALSDAYRIPVNLLWEVTETKLREALQNIDIPEVDRSLLRHVLFDNDAWPVKLIIRPLLEADGVPGAMPSGKGAGPNPFHPKSRTVPSSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ71</accession>
    <name>A0A398CJ71_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease Y</fullName>
            <shortName evidence="7">RNase Y</shortName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">rny</name>
        <name evidence="10" type="ORF">D3H35_11770</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endoribonuclease that initiates mRNA decay.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RNase Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03356">
        <property type="protein sequence ID" value="RIE03356"/>
        <property type="gene ID" value="D3H35_11770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00335">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017705">
        <property type="entry name" value="Ribonuclease_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022711">
        <property type="entry name" value="RNase_Y_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF15">
        <property type="entry name" value="PTHR12826:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12072">
        <property type="entry name" value="RNase_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03319">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="9">
        <location>
            <begin position="329"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="59"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="513" mass="57974" checksum="DEC18028D5B8124C" modified="2018-12-05" version="1">MDPIFWILIVLVVGAVFFGIGYVVRKSIAEAKISSAEQAAVQIVESAKKEAEAIRKETVLEAKDEVHKLRNEAEREVRERRNEIQRQERRLLQKEESLDRKLEALERKEEQVANKEKRVEEIQDQVEVLHKQQLTELERISNLSMEDAKQLILSTVEQEVRVETAQLIKEIEQQAKEEADKRARDIISLAIQRCAADHVAETTVSVVALPNEEMKGRIIGREGRNIRALETLTGIDLIIDDTPEAVILSGFDPIRREIARTSLEKLVADGRIHPARIEEMVEKSRKEVDERIREYGEQATYEVGVHGLHPDLIKILGRLKFRTSYGQNVLKHSMEVAYLTGLMAAELGEDVTLAKRAGLLHDIGKALDHEVEGSHVEIGVELGKKYKEHPVVINSIASHHGDCEATSVIAMLVGAADALSAARPGARRETLETYIRRLEKLEEISESFEGVDKSYAIQAGREVRVMVQPEKIDDTEAFRLARDITKKIEGELDYPGHIKVTVIRETRAVEYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJC5</accession>
    <name>A0A398CJC5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_19350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02793">
        <property type="protein sequence ID" value="RIE02793"/>
        <property type="gene ID" value="D3H35_19350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017211642" evidence="2">
        <location>
            <begin position="22"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="77"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="307" mass="34277" checksum="2298696A283D3030" modified="2018-12-05" version="1">MSLLVFGLALLWSMGEVPAALAEAHTVSTARADNLKELMKNGSQVKPSSRHPAGGHWQELQRRYRGVFVLYASRGSRQVALTFDDVPDPRFTPQILDVLKRKNVKATFFVVGKRASKHPDLVTRMQREGHAIGNHSYNHPDFSKLTLSEMQGQIRRSQNIIEGIVGYEPRLIRPPYGEINAEQLQWAKENGYTVVNWDVDSSDWRQLPAERIFRNVTRSVKPGSIVLMHAGGGEGQSLAGTVAALPRIIDWLRANGYQAVTLPELLKVPEKREANVSERTHVPKVPQTAEEMPGTSDEIPGVLLPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJF2</accession>
    <name>A0A398CJF2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamine pyrophosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_19515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02823">
        <property type="protein sequence ID" value="RIE02823"/>
        <property type="gene ID" value="D3H35_19515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="202"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="398"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="588" mass="63891" checksum="B8DEDEFDAEF87861" modified="2018-12-05" version="1">MKLSDYVIDFLASRGVNHIFEMTGGAITHLLDSAGARPDVECVSVHHEQAAAFAAEAYARTNGSLGAAMATSGPGALNLLTGIGSCFFDSVPCLFITGQVNTFEFKFELPIRQLGFQETDIVGIAKPITKWAELVTDPGRIRFALEKAVHTAQKGRPGPVLLDLPMNVQRADIDPERLESFYDSNEYREYESALPVLDGRLVDQAMDLLIRADRPLMLVGGGVRASGAAELARTFADFSGIPCVSSLLGLDAIPFDQKLSFGLIGSYGHRYSNLAVANCDVLLVIGSRLDTRQTGTRPETFARGAVVVHVDIDVAELNRKVKADLAIRCDAKAFLSALCDAAQSTEWPAYAAWHEALNGWRDRYPTRNPSVASDGIDPNLFMELLAERSSDGDIVCLDVGQHQMWASQSFRLRPGQRLLNAGGMGAMGFGLPAALGAAKAAVGSRVIAILGDGGLQVNIQELDTVLRHRLPVKLFVMNNRHLGMVRQFQDMYFDGRHQSTVVGYGCPDLVAIAQAYGWNAYRLDGWEAADAVIAHALSQEGCVLVDVRLDLTTTVNPKLTVGRPLEDMSPFLERDELKRTMIIDPLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJT4</accession>
    <name>A0A398CJT4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_16980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02402">
        <property type="protein sequence ID" value="RIE02402"/>
        <property type="gene ID" value="D3H35_16980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="17"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="93" mass="10770" checksum="8625DCB205DCD456" modified="2018-12-05" version="1">MDEGKYLYPKGELSMIRIIHAEDEESWRYLIANKINRESDMQVISSVTSVNECLQELDRAPYDIALIDLNLSEDEDYAGGYGLPEKFNCYIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJW4</accession>
    <name>A0A398CJW4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02993">
        <property type="protein sequence ID" value="RIE02993"/>
        <property type="gene ID" value="D3H35_20540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="29"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="268" mass="29932" checksum="A798C18BD9875A30" modified="2018-12-05" version="1">MEPIVKSISCKQTPITYYIWGNSNADTLLLLHPAFADHTIFEPQTAFFQNRFRVIALDMPGHGECRTKGAQATLGDMPDILDRILADNRISSCHLIGVSLGSLVAQAFADRYPRAVRTVTAVGGYSIHKANDAILKEQRKEGWRWLLYLLFSMKKFRKHVVSVSCSTAEGRAAFARGIERFGRKSFLAMAGMNAFFVKKDSPVPYPLLILTGEHDRQLAHDAAAELHRMEPLSEKITLPRAGHCANADAPYEFNTIVEKFLLANRANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK41</accession>
    <name>A0A398CK41_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_18880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02715">
        <property type="protein sequence ID" value="RIE02715"/>
        <property type="gene ID" value="D3H35_18880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004761">
        <property type="entry name" value="Spore_GerAB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03845">
        <property type="entry name" value="Spore_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="129" mass="14405" checksum="0B27ED5CEFE2EAC4" modified="2018-12-05" version="1">MTDSFVFPVMIAARYISFADFLQHIEALIVAIWIAGIFVKVSVFLYVQAISLAQWLNLNDFRPLVFPLAFLDLVYSFWVISNQSEIATLLGSSGNLYTLFVLIVLPGLLLAVARIRNGRVHRTVGNGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK63</accession>
    <name>A0A398CK63_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TIGR01212 family radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_10380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03696">
        <property type="protein sequence ID" value="RIE03696"/>
        <property type="gene ID" value="D3H35_10380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005911">
        <property type="entry name" value="YhcC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF1">
        <property type="entry name" value="PTHR11135:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01091">
        <property type="entry name" value="uncharacterized_CHP01210-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01212">
        <property type="entry name" value="TIGR01212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="29"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="319" mass="36905" checksum="7877078F79DAF6AE" modified="2018-12-05" version="1">MNLWTEASTQPLLWGDKRFHTWNYEMREAFGTKVFKVMLDAGFTCPNRDGTIAAGGCTFCSTRGSGDFAGSRRDDLITQFETVRDRQHLKWPEAKYIGYFQAYTNTYAPLETLREYYEAILRQPGVVGLSIATRPDCLPDDVVDYLAELNERTYLWLEMGLQTVHESTSTLINRAHDTECYRDAVERLRKRGIRVCTHIIYGLPGEDRDMMLETGRQVAAMDVQGIKIHLLHLMRKTPMVRQWREGLLRFLEKDEYVELIADTLELLPPEMIVHRLTGDAPRDLLIGPMWSLRKWEVLNAIDAALVRRDTWQGKAWRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKU7</accession>
    <name>A0A398CKU7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Recombinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_24450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01508">
        <property type="protein sequence ID" value="RIE01508"/>
        <property type="gene ID" value="D3H35_24450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="6">
        <location>
            <begin position="12"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="7">
        <location>
            <begin position="168"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="4 5">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="558" mass="63441" checksum="AD25CCEE7CA73C68" modified="2018-12-05" version="1">MLSANESNSPVAAALYIRVSTTEQAELGYSIVAQEQALRQYCEATNKVVYEVYCDRGITGTSIEKRFALKRLLNDAKKGLFQEVLVWKVNRMARVNLDLLKIVDELSRHDVGFRSITESHVDTTTKHGVFNLHMMGAFSELDRNTILENAQMGLKQRARTGKHNTRAPLGYQVAILSLSGRKRNTRIEVVPEEAAIVRRIFEQFASGRGLRSIANSLNRDGHRTKKGNAFTICAVGDILDNAFYVGKIIYLKYLDWNKKRRKGKNTNPIIADGQHDPIISEELWDKVRFLRQQKSVVSEKRFHGDLLLTGLLRCPVCGSAMTGSRTNNKDKHGNLITRFYYSCSKMRSSGAVVCKANSIRKQDAEDYLFARLKEVLAKPHILRGIVRGINDRKVNSVRPLQEELAAVCSGIEEINAKKNRLVELCELDDFDRLFVTERIKNLDSDLYQLHARRADIANMLTGDYTEPVSYETVRSLLGRFEHLLRYSNRDQRKTLLHLIISKITLTSDKKVDKIEMIFDEMTEQHFLSAAPSSAIAEEGAFLFERKVPDLTNRLTITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKZ4</accession>
    <name>A0A398CKZ4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D3H35_14050</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01899">
        <property type="protein sequence ID" value="RIE01899"/>
        <property type="gene ID" value="D3H35_14050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011620">
        <property type="entry name" value="Sig_transdc_His_kinase_LytS_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07694">
        <property type="entry name" value="5TM-5TMR_LYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="253"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE01899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="464" mass="51252" checksum="F1446A508EC231C1" modified="2018-12-05" version="1">MIVILEHFSSLGKGYIAYCVVLYHRELLSGLSAVLEERILLLLLENLLLHLLIVVAPNLVFVSFQDRLKYGHAPILFGLIQGGAAVCSVVFSMEADEAYWNLHIVPLVISFLYAGPLAGCIVFVCAFAAQLSMGEFDRFGMALLDLLAAAIPAKLGPGFASMHPRRRRMMFGLSITLPLLFPFMFHYLYIQFNENTGIFEKFEGLESLLFGFIYLLGIWVAGKLNETMLERKRSKLEHLRAEKLDTLGELAASIAHEVRNPLTVVKGFLQLMQRKDQDKAQAYLPIALDELERAETVIGNYLSFSKPHLKKMEPFCLSTQLSEVHALLLPLAGDRGVCFTFEAENGVTVTGDSAQLRQAIVHIVKNAIEATPTDGNVWVAMRSEGGEAVVEVKDSGVGMTEEQLERIGTLFYSTKVKGTGLGMTVAWRIIRQMGGDLVYRSRPNIGTEVTITLPAGKAAKSAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL82</accession>
    <name>A0A398CL82_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mannitol_dh domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03020">
        <property type="protein sequence ID" value="RIE03020"/>
        <property type="gene ID" value="D3H35_20710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol_dh" evidence="1">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="98" mass="11134" checksum="570818D85A245A85" modified="2018-12-05" version="1">MTKLSRAALDEAGRERWERLNDSPVTILQIGEGQFLRGFFDWMIHRCRAEGLYDGAIAVSQPRPSGKRKLDALARQDGLYTLVIRGLRMERLSSAKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLB2</accession>
    <name>A0A398CLB2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03453">
        <property type="protein sequence ID" value="RIE03453"/>
        <property type="gene ID" value="D3H35_12400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="217" mass="23274" checksum="F6D01822FC52A6EA" modified="2018-12-05" version="1">MKGSTHLAIGAAVGAAASLYYPFSFHSAALYVTAASVSALSADLDGPSLLSNKLKLGKLAEALREFVIWAGVLLMGIVAYRYYSDLRFDKTFAASGIALFLIGIATKEGVIRNLLVSVIGGGFLYAGFTSGQPWLMGFGLFVAWAPWLKHRGMTHTVWALLLWALIGRGLERQLGLDGIMAASAAGYASHLLADTLTPQGVKWLYPIYKKSIKFPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLI5</accession>
    <name>A0A398CLI5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_21165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03092">
        <property type="protein sequence ID" value="RIE03092"/>
        <property type="gene ID" value="D3H35_21165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="38"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="422" mass="48424" checksum="6F3747899A2D3427" modified="2018-12-05" version="1">MEIILWIGFYFLTFYAFLPAFVSRVFGFRVFMRGKTKSEIALTFDDGPDPVYTPILLDLLKKHGAKATFFVVGANAEKYPELVSRMHEEGHIVGIHNYVHHSNWFMRPKTVKRQIHRTSDVIKKITGARPKYYRPPWGIVNVFDYGNIGYLQIVLWTSMFGDWRKKIGAENLYLRMRKKLKPGEVFLLHDCGITVGADRDAPANTIAALARILEDGRELGYRFVGIDEMIELTEGKKSKISTEAEGSPSVGPVKRVLVACWMLWEKLFHVTFRLKPIGDGKSFNYRVRKYSGPVVYLRDGKTLRSGDKIMEMHFENRMLYDMGMNSRSAVHTAIRLVRSVADALPFYARELESLPDRDDVKALYGVSIIHRGSDGLGFQIFDLPRGMFSWTSDLYLRFMMSIITPEGSKRVRERGTRLHPGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLQ5</accession>
    <name>A0A398CLQ5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_10825</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03583">
        <property type="protein sequence ID" value="RIE03583"/>
        <property type="gene ID" value="D3H35_10825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="17"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="316"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="749" mass="86046" checksum="2455EA115685AA58" modified="2018-12-05" version="1">MHTHRHFFTRKQTEIGVALNEVQQQAVLHSEGALLLLASPGSGKTTTIIMRIGFLIEEKGVPSSRIKAVTFSRASAKDMKERFDRFFPDHAAAARSVDFSTIHSLAFAVARDHFYKTGITYQLIEGEMDLEELELSGPDQLVLHKKFILRQLFKSLTGESITDDQMEELTRYISYIKNKLVPENQWAKVKCDVKEADKLLREYERFKREGTGKLLVDYDDMLTIANDALETDRALLARYQRRYDYVMTDESQDTSLVQHAIIEKLVREHGNLCVVADDDQSIYTWRAAEPQYLLDFRKTYPRAAILKMEQNYRSSPDIVSVANRFIKQNKNRYDKNMFTKNKTHKPIKIKSLPDYRVQAKHLAERIAKLDDWRETAILYRNNSSSIALMNEFDRQGIPFYMKDGDNRFFSHWVVEDVLNFMRMSFTDKRPDILERIHTKCAGYITKQQMAAVKGFANNESVFDNLINYVHLQEYQIKLLQGCKETFEHMSGMAPKKAIVVIRYKLGYEKALEKMCDKFGFRKEVLLGILNTLEDIAESLETMEEFAKRLKHLETVMKTSKFNKNANAVTFSTLHSSKGLEFERVYMIDLVEGIIPSDEDAKKVQGEYTDAMEEAVRLFYVGMTRAKRHLELLSYKMRDGAEAKESRFLAGVRNIQSPPKEAEAAAGKSGVSVNVGTVKERSKPRNPNAIRDKALLVPGRSVAHRVFGAVKIVKVEGDRLQIKVSSEMKELSVAACLERGLLEKIMTKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMD0</accession>
    <name>A0A398CMD0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GH26 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_16835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02379">
        <property type="protein sequence ID" value="RIE02379"/>
        <property type="gene ID" value="D3H35_16835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006080">
        <property type="term" value="P:substituted mannan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022790">
        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000805">
        <property type="entry name" value="Glyco_hydro_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079">
        <property type="entry name" value="PTHR40079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02156">
        <property type="entry name" value="Glyco_hydro_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017295796" description="GH26 domain-containing protein" evidence="5">
        <location>
            <begin position="32"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="GH26" evidence="6">
        <location>
            <begin position="141"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="542" mass="60412" checksum="4D8823F049C1BC5A" modified="2018-12-05" version="1">MNGSSATKRFGTWAIAALLALTLAPSTDTHAAKAPAKINVWKVYEEANKAKDKKDFKTAVAKYLQIALEFIAKKEFNNAALMYNKAGDLQSQLALYDDAVKSWDLEAANWTKANKTQEAIAAARKADWIRSRFELYVADESAAGSVYHGVKYEPRNGTLLGAYAENDPAVHNANGGDKFYMTDFPALTGKKHAMYLLYTTYGLNFFESYKRHIDIARKEGVALQVALQPMKGLGAVQDDEYLRSLARSARDAQIPIFLRFANEMNGSWVKEWYSADPKPYIEKFRIVAKVFHEEAPNVVMVWSPNYFPPDNITKYYPGDDAVDWVGVSMYQTFNGSLDPLKKGIDRSSYIEKFDHIYKLYAKKKPIILSEGAVSYTDPVLHSDRNAWAAYQTKVFYESIPLLYPGVKAVVWFDATKKEEGRLNSYLLSKSPSLLGAYKQSVQNPYFLSGVTENSKVAYKSLASGKLAAKPQTIAAYVKTVSPILGKVEYSMNGKLVAAAKTAPWTLAYDFTSLKGKTVELAVKAFDDKGASVSSRTFKLTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMM3</accession>
    <name>A0A398CMM3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_14840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02038">
        <property type="protein sequence ID" value="RIE02038"/>
        <property type="gene ID" value="D3H35_14840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032812">
        <property type="entry name" value="SbsA_Ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13205">
        <property type="entry name" value="Big_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Big_5" evidence="2">
        <location>
            <begin position="36"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Big_5" evidence="2">
        <location>
            <begin position="129"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="268" mass="28737" checksum="25CEF1B75C591819" modified="2018-12-05" version="1">MDVHDGGIVRYGSSYRKQFRVYFLGSVDSAGGLNGVLSVTFSEKVYTGSGAIEIRKSDNTTYCSIPVGAGAVTLDSAGKVVTISPSVYACPKFVNGSTYKLVIGNQAFRDGNGNYYAGQSGWSFKASVDNTLPSVSIYSPAVSAKAVSVNTTTLTLTFNKAVKQVGEDVVTAVAFPQSKPSTASERINWTVSFDSTDNKKIILTKDDGEKDFNPNTKYVVNIPAGVISDLAGNLYPGMLNLYQWTFDTGAAGEFQLCKKRKWTEPLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMM5</accession>
    <name>A0A398CMM5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03500">
        <property type="protein sequence ID" value="RIE03500"/>
        <property type="gene ID" value="D3H35_12695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="729" mass="83014" checksum="B380249BF654DAD5" modified="2018-12-05" version="1">MLMWDKPEVVEGLTVYRDHEDRTLYYVLPSVPGFRIDDNGLPVFKFIKYRFPIDRPDGKKGGGFLIADVEFSVPEDKLAKVKEALQERLDEQARNLGQQTPASPVKFGQLSFLRGTASITVLDDGGSLVEKVINPAAPSLYGKMITPFTAELSAEGATLLEQALQGKGAIVQVAYDLWMPVRLPPVKARIWFKAEKFMEFHQEIDVEENFWSEDDYREKISEKFSQREAGGVQIDPGGVVDQKVIGAVRDWALRNWEDRLAKMVLGDIPPVDRDASKWYTEHDFENISRDVISSRVSSFDIKYEEGSIMEWNPSPRGSLPNITTLTGRDGQPFKWEDFSLTVDLDDPFFRQLRVTTRANADFDKLPLNSVEVKIEYKQGAEHSIKEFDLRSPDDLGKFASFIANDSYKYKYSYQVNYKGEAQAYQSPEIESDEENLTINVGDIGILLVDVAPGDLNFNQVSEAQVTLQYEDRDNGVDLIEDVFKLDKDHSEHRFSRVIFKPRKNPYRYRVNYFMKENGKEFKSDWQSGVADKLFINDPFSASRTVSVRGFGDFAARIDSIFVDLVYRDEENNYGQSQSVALSQAVNFFDWTFPVITETGGQVTYSANIRFKDGTFEEVPTTVSDRNTIMLGDVALTQSIQLVPDLINFDLVKLVKVTLHYADEANGIDETKDFLFKKGAQEAKWEFTYKDKSKQVYEWRASYFMVDGSVKNIEPGNTSEKTIVLPETPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMP8</accession>
    <name>A0A398CMP8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_17670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02519">
        <property type="protein sequence ID" value="RIE02519"/>
        <property type="gene ID" value="D3H35_17670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004761">
        <property type="entry name" value="Spore_GerAB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03845">
        <property type="entry name" value="Spore_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="59" mass="6015" checksum="25F7176DF70E07F6" modified="2018-12-05" version="1">MGRIGSLQLWSLVFSFVFASGVAFLIGPLAHVGGTDGWMSILFAAIAGTGLGSRAFPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMQ3</accession>
    <name>A0A398CMQ3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferric oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_26015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000045">
        <property type="protein sequence ID" value="RIE00871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00871">
        <property type="protein sequence ID" value="RIE00871"/>
        <property type="gene ID" value="D3H35_26015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="177" mass="19795" checksum="E8516F61588EBCD2" modified="2018-12-05" version="1">MTDWLMQLPTWVITRVAGLSAFYLLTIGVVSGIFCGSPGIKGVWKARIFRFHSWTQGFGLIVAIAHVIVLAIDRYAKFDWITLIIPFSAPQHRLEYGLGSLAMYGLLAILLTSDFRGLLANRIWKTIHMTAYPVFFLALIHGLFSGTDSAKPLVFWSYAAGPARRSSHRHSGVNRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMU1</accession>
    <name>A0A398CMU1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_11010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03560">
        <property type="protein sequence ID" value="RIE03560"/>
        <property type="gene ID" value="D3H35_11010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="373" mass="43829" checksum="B20F10BE35AA1687" modified="2018-12-05" version="1">MLIFLEGLPGVGKSTNTGLLYRQFERNGFATSWVHEFDRPHPVLFFHEACLKKDEYRSWKHRHGGELTVLDEMVRFRDVTVGIDLLELEWNYSDRVSETAFAELREKDVWNFSLEEYMDVALEKWRSFAEKLAEKPEQVVLLDSCIFQYQIFSFQLENAPAEELNRFVQALWDIVSPLQPRLVYLYRNSVADAIDHLRAARGARFFRHIWERDRSRPYYKARADSVETYFEFLNDYNRTAQELFEKAPCPKLGIEVTAGDWKEYERRLLAFFDLTPISDLQEEFEGGEFFNDALGISLQIKQVEGAWLLTDPEGNERQLHPRSSKEFYIRDLPVLLDTSVKNQIVISGASLNNRWTETGLVFAKNRDWKPRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMU8</accession>
    <name>A0A398CMU8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000035">
        <property type="protein sequence ID" value="RIE03612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03612">
        <property type="protein sequence ID" value="RIE03612"/>
        <property type="gene ID" value="D3H35_10760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="112" mass="12489" checksum="D3A23D5022537FA9" modified="2018-12-05" version="1">MKDAVKGVKSNFRIDGIVFIRRRHLVSGPEGAVRFLLRTGVPVPERDPSGQAVLTLWLFGQNQSSRLQFGVQWTAEQSTLQALAAEIVRRYPERKLTAASIRLMPLKSISTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN43</accession>
    <name>A0A398CN43_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03712">
        <property type="protein sequence ID" value="RIE03712"/>
        <property type="gene ID" value="D3H35_10475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="121" mass="13693" checksum="84297B0C9E1220B8" modified="2018-12-05" version="1">MTTFGNRLRNARNGKKLTQTDVAARLGLDFTTISKYENNKSEPDNEILRELANLYEVSVGWLITGSTSEDEGSAPDHLMVNGATELLSDEEGLFLLDNLEMYRLLKAKREKERRNKEEAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN59</accession>
    <name>A0A398CN59_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Molybdenum cofactor biosynthesis protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_10405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">May be involved in the biosynthesis of molybdopterin.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the MoaB/Mog family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03732">
        <property type="protein sequence ID" value="RIE03732"/>
        <property type="gene ID" value="D3H35_10405"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012245">
        <property type="entry name" value="MoaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43232">
        <property type="entry name" value="PTHR43232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006443">
        <property type="entry name" value="MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="7">
        <location>
            <begin position="19"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="174" mass="18871" checksum="BDF31D05E529F244" modified="2018-12-05" version="1">MSASTEQHRREAPDNVACLILTVSDTRTPDTDKSGQLIEQLLGERGYRVVDRRIVADEYALIAQLLDEAAADPAVEAVLLNGGTGIAARDTTYEAVRDRLDKEMPGFGEIFRYLSFTEDIGSAAILSRAIAGTIGSTAVFSMPGSTGAVKLAMTRIIVPELGHVMREIYKDRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNA6</accession>
    <name>A0A398CNA6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative septation protein SpoVG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">spoVG</name>
        <name evidence="5" type="ORF">D3H35_23805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Could be involved in septation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SpoVG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01397">
        <property type="protein sequence ID" value="RIE01397"/>
        <property type="gene ID" value="D3H35_23805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00819">
        <property type="entry name" value="SpoVG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007170">
        <property type="entry name" value="SpoVG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036751">
        <property type="entry name" value="SpoVG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38429">
        <property type="entry name" value="PTHR38429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04026">
        <property type="entry name" value="SpoVG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160537">
        <property type="entry name" value="SSF160537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0717">Septation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="94" mass="10473" checksum="A624148E3FAC5C4A" modified="2018-12-05" version="1">MQITDVRLRRVNSEGRMKAIASITIDNEFVVHDIRVIDGNNGMFVAMPSKRTPDGEFRDIAHPISSGTREKIQAAVLAEYERAAQEEDVMVEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNI2</accession>
    <name>A0A398CNI2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenylacetate--CoA ligase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_07895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03882">
        <property type="protein sequence ID" value="RIE03882"/>
        <property type="gene ID" value="D3H35_07895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="101"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="448" mass="50958" checksum="7F2DF7813EB648FE" modified="2018-12-05" version="1">MKTQSHKMSVSIDEHQSHLERLIPFFTRLDEEGTTIEKLPQERREQYQLEAVNLTLEHIWSHNEFYRTALEEAGFAEPRIDSLEQLSTVPLLNKDVIRGDKRKLLCVEPKQIGQVHLTSGTSGKPIYTSYTLADQYVYDLLPKYLELFTEKEEDVAAIALPYEFALPGLGFQRLYQFAFGTAVLSLGKGGYMAPVDKSLALMKEYEATVLATTPSYAALLAEESERIGFRLGEDIKLRRIMLTGEGCSHTFRKRLEKAWGCEVSFFYGSTECGVVAVECKEHNGYHIMEGHVKVEIVDPASGAPLGYSQTGEIVVTTLLREGMPMVRYRSGDIGYLQKSQCACGIRMDVLQLRGRMENMINLNGDDYSPFLLEHFLMEVPDVGMWYHFILEQGRLTIEAEPYRTKLTDSQLAEKIRAHMSNRTGVDCHVEIKRDLPRTFGKATRVFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNQ6</accession>
    <name>A0A398CNQ6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04125">
        <property type="protein sequence ID" value="RIE04125"/>
        <property type="gene ID" value="D3H35_08135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="221" mass="24455" checksum="47AC1E291EC7F2D7" modified="2018-12-05" version="1">MIALTPEAVIFDLDGTLFQTETLLETVHARVFDTLREEGLYTQETPPIASLLGSLGMLLSDIWKKIIPDGSEEAHERANVLMLQYELEELEAGRGSLYPHVRETLEELRNRGIRLFIASNGLEEYVKGVPVAKEIAGLFEGTYSAGEFATLSKVDLVRKLLDTFGVKSAWMVGDRSSDVEAGKKNGLFVVGCDYAGFRREGELDGADAVIRSFRELITLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNS9</accession>
    <name>A0A398CNS9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="3">DERA</shortName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="3">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">deoC</name>
        <name evidence="4" type="ORF">D3H35_27905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00564">
        <property type="protein sequence ID" value="RIE00564"/>
        <property type="gene ID" value="D3H35_27905"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="3">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="223" mass="22841" checksum="F2F98F0B14C7D2F1" modified="2018-12-05" version="1">MNADQIAKMIDHTLLSPVSTKEDILRVCEEAKRNGFATVCVNPYWVPTAAEALKGSGVGLTTVIGFPLGASRTEIKAAEATDAIEAGATEIDMVLNVGALKSGERDAVLKDIRAVVAASEGKAAVKVIIETCYLTDEEKRTASLLSKEAGADFVKTSTGFGTGGATVEDIALIRAVVGPDMGIKASGGVRDLATARKLIQAGATRLGASSSVAIVTGGTGQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNX7</accession>
    <name>A0A398CNX7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0178 protein D3H35_06240</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_06240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0178 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04215">
        <property type="protein sequence ID" value="RIE04215"/>
        <property type="gene ID" value="D3H35_06240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00489">
        <property type="entry name" value="UPF0178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003791">
        <property type="entry name" value="UPF0178"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35146">
        <property type="entry name" value="PTHR35146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02639">
        <property type="entry name" value="DUF188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="156" mass="17175" checksum="77D8457502DC3934" modified="2018-12-05" version="1">MVLVRNRVVVDGDACPVKSEIARTVQSLDATALMVSSHAHRLVAEDRVSVVTVDASNQSADLYIANVLTRQDVLVTGDYGLAALGLARGAAVLTPRGREIREADIDELLAQRHFSAKQRRGGARTKGPPPFTNEDRDRFQQKLTTLLRGMQENRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP04</accession>
    <name>A0A398CP04_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RsfA family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04245">
        <property type="protein sequence ID" value="RIE04245"/>
        <property type="gene ID" value="D3H35_06410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014243">
        <property type="entry name" value="DNA_bind_RsfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41302">
        <property type="entry name" value="PTHR41302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02894">
        <property type="entry name" value="DNA_bind_RsfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="214" mass="24853" checksum="279384F5A4BAB70E" modified="2018-12-05" version="1">MTAVRQDAWSPDDDLILAEVTLRHIREGSTQLAAFEEVGQRIGRTSAACGFRWNSCVRKKYDDAIGMAKQQRQKRNYLKKQGITTISGTDRLTLEESESAKGELLSSESISLEAIIRYLRQWKGTVQEMSRQIRQLEKELKEKDDKLNAYLSENERLSKEVNEVQTDYQVVNDDYKALIRIMDRARRLAFLTEEPDEDRTRFKMDANGNLERIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP37</accession>
    <name>A0A398CP37_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation protein YhbH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhbH</name>
        <name evidence="2" type="ORF">D3H35_08400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03970">
        <property type="protein sequence ID" value="RIE03970"/>
        <property type="gene ID" value="D3H35_08400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014230">
        <property type="entry name" value="Spore_YhbH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006698">
        <property type="entry name" value="UPF0229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30510">
        <property type="entry name" value="PTHR30510"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04285">
        <property type="entry name" value="DUF444"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02877">
        <property type="entry name" value="spore_yhbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="381" mass="44067" checksum="7AC92154CC10074D" modified="2018-12-05" version="1">MNQPSFLLSREDWSLHRKGYQDQARHQQKVREAIKQNLPDLLSEENIVLSDGKQIIKIPIRSLDEYRFIFNGNKKKHVGQGSGDSQVGDVLGRDPAEGPGKGEGAGDKPGDDVVEAEISIVELENLLFEELELPYLKRKEKEQIEVREVRFTDVRRKGIMSNIDKKRTILENLRRNSREGNGEIGGISPDDLRFKTWEEIIKPQNNAVILAMMDTSGSMGSFEKYCARSFFFWMTRFLRRQYEKVDIVFIAHHTEAKEVTEEEFFTRGESGGTICSSAYVKALEIIDSRYPPSLYNIYPFHFSDGDNLTSDNERCVRLIHELMKRSNIFGYGEVNQYNRSSTLMSAYKHVDHEQFLYYVIREKSEIYSALKTFFRKRDAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP98</accession>
    <name>A0A398CP98_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_13035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01727">
        <property type="protein sequence ID" value="RIE01727"/>
        <property type="gene ID" value="D3H35_13035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="259" mass="27799" checksum="C685FBB5386DCC49" modified="2018-12-05" version="1">MSAWLLLFRKEMLENARNYKWVWIPLVFVLLGISNPISTYYMPQILKAGGVAEEAAKLIPVPASAEIMAKSLSQYGTLGLLVLALSFMGTVAGERQSGSAIMVLVKPVSHASYILAKWFGMTVLTLAAVGLGQLGAWYYTNVLFEDVSFQAVWSSCLVYALWLLFVNTVTLLLSCLLKSQSGIAFLSLGAAAVISLLTQLFGDAMSWSPSRLTGEASRILLEGPGGSQDLWLVVGAAVAIIAALLFGAVAASKRMWVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPC3</accession>
    <name>A0A398CPC3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_13215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01757">
        <property type="protein sequence ID" value="RIE01757"/>
        <property type="gene ID" value="D3H35_13215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="326" mass="38906" checksum="D128558E455DD164" modified="2018-12-05" version="1">MQPKPLRIISVKERRGEIEGDRFYPYYTEFYYVFRIVSLESGTIRMHKRELNSGTWYHTFGRKCDQELNGGTWYHTFGRKCDHELNSGTWYHTFGRKCDHELNSGTWYHTFGRKCDHELNGGTWYHTFGRKCDHELNSGTWYHPFGRKCDHELNSGTWYHTFDRKCDQELNSGTWYHTFGRKCDQELNSGTWYHTFSGKCDQELNSGTWYHTFGRKCDHELNSRTWYHTFGRKCDQELNSGTWYHTFDRKCDQELNSGAWYHTFDRKCDQELNSGAWYHTFDRKCDQELNSGTWYHTFGRKCESGNEPKTSNGGAGITTLHRHFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPM1</accession>
    <name>A0A398CPM1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Esterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00904">
        <property type="protein sequence ID" value="RIE00904"/>
        <property type="gene ID" value="D3H35_25365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="266" mass="29958" checksum="B4270466D80AB0EF" modified="2018-12-05" version="1">MPLFQCDFFSDTLKMATSMTVILPRDPSKFAKEPDGSSSGKYPTLYLLHGLSDDHTIWLRRTSIERYADEFGIAVVMPNVHRGFYTNMKNGFDYWTFVSEEVPSFAQASFPLSARREHNFAAGLSMGGYGALKMALRRPEMFAAGAGFSGALDVVSESLDFLFEKREYERIFGSKAETRGSDDDLFRLAEKLAASDGPVPKLYQCCGTEDFLYEDNLRFLKHIRALGLELLYEEGPGGHEWGYWDAAIRRTLEWLPLPERVGAGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPP1</accession>
    <name>A0A398CPP1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000028">
        <property type="protein sequence ID" value="RIE04150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04150">
        <property type="protein sequence ID" value="RIE04150"/>
        <property type="gene ID" value="D3H35_07840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="264" mass="29317" checksum="3859625C4C470DC0" modified="2018-12-05" version="1">MVGEYPVIVLITVRRYPPGRYVRHVFIVISGSLFSARRHYFLRGVLVVQGRGVVLGRVAVCNVFRATVVGRRMADQSEDAAKQLKKYGFELNLNQKMSGESAGSNSTVKLDMQGRAELGPLKLDQTNKSDIDGEKSSLRAILVPDAYYMYSDEFKEWSKLSKEETANVVRTLSSLQINLAESIEGVRGLGSALAVKPSGDEIAISYNGNGPEALTFSRACWRAHWICRAWSRPFATRSRSIRSRYSSSWTPSIIGRCRTGSIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPW9</accession>
    <name>A0A398CPW9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2292 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02788">
        <property type="protein sequence ID" value="RIE02788"/>
        <property type="gene ID" value="D3H35_19320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018743">
        <property type="entry name" value="DUF2292"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10055">
        <property type="entry name" value="DUF2292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="61" mass="7025" checksum="9B59177D73119059" modified="2018-12-05" version="1">MAKPVELNENWLVRITEAVEGLKYGTVQIVVHDGRIVQIERTERFRYEGSVEGKQPARKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ19</accession>
    <name>A0A398CQ19_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Divalent metal cation transporter MntH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mntH</name>
        <name evidence="6" type="ORF">D3H35_03795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">H(+)-stimulated, divalent metal cation uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04625">
        <property type="protein sequence ID" value="RIE04625"/>
        <property type="gene ID" value="D3H35_03795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00221">
        <property type="entry name" value="NRAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="PTHR11706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="452" mass="48794" checksum="A0D5937842E25267" modified="2018-12-05" version="1">MSDNATPLNTNTDRGWRNTRTQSSMPEVYRSMKIPKSGSTFRKFLAFAGPGYLVAVGYMDPGNWATDLAGGSKFGYTLLSVILLSNLMAIVLQALAGKLGIVTGRDLAQACRDHYSKPVSMALWFLCELAIAACDLAEVIGTAIALNLLFGIPLLYGVILTALDVLVILLLQNKGFRFIEAMVITLIGTVGVCFLIEIIMSNPVFGDVMKGFVPSGEIVSNPEMLYIAIGILGATVMPHNLYLHSSIVQTREFDQTEIGKRQAIRFATADSTIALFFALFINAAILIVAASAFHTSGYTEIAEIGEAYHLLAPMLGSTMASILFGVALLAAGQNSTLTGTMAGQIVMEGFLNIRLAPWLRRLITRMIAIIPAVIVTAIAGEKGTTDLLILSQVILSLQLSFAVIPLVKFTSDKKKMGVFANPPWLRALSWAVAVIIAGLNIYLLYQTFNGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ82</accession>
    <name>A0A398CQ82_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04370">
        <property type="protein sequence ID" value="RIE04370"/>
        <property type="gene ID" value="D3H35_07195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="228" mass="25561" checksum="D3D2823A120856DD" modified="2018-12-05" version="1">MNRTASIIRMHTNDRFFWLYLPLIILGSSFFINLIISALIDEEGGLYTGGLASIYVYTGIISMITVSQTFPFALGFSVTRKDYFFGTAATAVLVSVITGAILYLLSTLENATSGWGVKLHYFHLPYFSDGPIYEQLSVSFLNMLHLYFLGFVLASLFRRFGRKGISIFFLLLLVVGTTLGYAVVYLEWYKPIGDWLSDQTALGLSAWLIPLILLYGAASYRMLRNSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQF1</accession>
    <name>A0A398CQF1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3 8" type="primary">coaBC</name>
        <name evidence="8" type="ORF">D3H35_07325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04390">
        <property type="protein sequence ID" value="RIE04390"/>
        <property type="gene ID" value="D3H35_07325"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="6">
        <location>
            <begin position="8"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="7">
        <location>
            <begin position="188"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="193"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="307"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="435" mass="45726" checksum="DD0F4755AE3DC56B" modified="2018-12-05" version="1">MVKPLEGKTILLGITGGIAAYKAATLCSRLVSLGASVRVIMTEGATKFIAPLTLQSLSRHAVATDVFDERDPSIVQHIDWADSADLAVVAPATANAIAKLANGIADDMLSTTLLAITAPIVVAPAMNVHMWEHPAVIENVNKLASRGVRFVEPGTGQLACGYVGKGRLAEPEEIAASIVGFLARPKPLAEKRVLITAGGTIERIDPVRYVTNDSSGKMGYAFAEAARELGAEVTLVCARTDGPPPGGVAVVTAESAEEMLEAVMSRLTESDYIVKAAAVADYRPLHRFDAKIKKSADTLTLELVKNPDILQTIGEWKAARPAGSRPYVIGFAAETNDLEKHALDKLHRKKCDLIVANDVSAVGAGFGSETNIVSVYGAEGLVENIPQTAKRLVAERVLAIAIDRANRETAASGLKQASRNSGAASGSPAAEEPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQQ4</accession>
    <name>A0A398CQQ4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01264">
        <property type="protein sequence ID" value="RIE01264"/>
        <property type="gene ID" value="D3H35_23025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="95" mass="10432" checksum="EF4DC9882AB84694" modified="2018-12-05" version="1">MGCIVVTASVANIIPYISLSVPINITITSVCIVLAYFFAPNNLERTSRIPTRYYPTLKYAAILLIAVNLLVRSDVLAVTFLIQCLSLIRKGGDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQW9</accession>
    <name>A0A398CQW9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02217">
        <property type="protein sequence ID" value="RIE02217"/>
        <property type="gene ID" value="D3H35_15885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010343">
        <property type="entry name" value="ArAE_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06081">
        <property type="entry name" value="ArAE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="347" mass="39025" checksum="6E57D9A3C705BA96" modified="2018-12-05" version="1">MTIGARVFKTGLAVALALWIGTLVGLESPLLAAIAAIFTIQPSIYRSWMQMLEQVQSNVLGAAIALGAVWLVGSTPVTVGLVCIGVILLCIQLKTEETIGLTLVTVVVIMEAHSQGWMLALERLAAVLTGMVSAFVVNVAVAPPRHRTRFVKQVQETQTMLSRLLRTAVSNELKENVFREEHEKLRTKLRKLEEFYDMFAEERVWRRKSRTARVRLLVVYKGMLTALERGVSLIDAVEDHYWGVKTAETWNHLVDRQIESLCGYHEQLLWKWEGVMKPGAAASAPPQEASLTLTELVEAQTKDREGTDRARLLVITSSVFSYEESMRRLDKLMEQWLHREEASPEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQY4</accession>
    <name>A0A398CQY4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03679">
        <property type="protein sequence ID" value="RIE03679"/>
        <property type="gene ID" value="D3H35_10290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="189" mass="20449" checksum="7D4F17832A74B0EA" modified="2018-12-05" version="1">MRYRTFAESLDGATNSGMRYRTFAESLGGATNSCTRYHTFAKSLGGATNSCMRYRTFAESLGGAANSGMRYRRFAESLDGATNSGMRYRTFAESLEGAANSGTRYRTFAKSLGGAANSGMRYHTFAESLGGATNSGMRYRTFAESLDGATNSGMRYRTFAESLDGAANSGMRYRRFAESLDGATNSGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQZ1</accession>
    <name>A0A398CQZ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore maturation protein cgeB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03208">
        <property type="protein sequence ID" value="RIE03208"/>
        <property type="gene ID" value="D3H35_19795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024542">
        <property type="entry name" value="DUF3880"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12996">
        <property type="entry name" value="DUF3880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3880" evidence="1">
        <location>
            <begin position="76"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="318" mass="36969" checksum="8102179D5D3BFF10" modified="2018-12-05" version="1">MFVATGKGYPYSPLDAALHESLMAVTEKVTYVTPQEDIAGIAAYSRPDLMFVLDGLEMPIEKVQAVRALNIRTAVWFTDDPYYTDDTSVLATCYDIVFTLERNCVDFYKERGCSHVHYLPMGVFPGHFRPRNPPMSERCDIRFIGTAFWNRVNWLHETLPLIEHRNVKVSGLWWDRLPDYSRWQSKIELDKWMEPGETAQQYNASRIVLNSHRAYDDDTVNRSQIKVPPASPNPRMFEIAACGTLQLTDWREDISLYYAPGLEIVTYDSPQDLAEKAKYYLENEEERQQIALRALYRTMKEHTYVSRFHQLLDMAFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR83</accession>
    <name>A0A398CR83_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_02790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05075">
        <property type="protein sequence ID" value="RIE05075"/>
        <property type="gene ID" value="D3H35_02790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="308" mass="32648" checksum="AB056F3525F6AE8F" modified="2018-12-05" version="1">MKRIPVPAPATAIFTLQSDGQGRIWGASGFGQTIFRLDPASGKSWSSSSVCNAGGEVYGMQFAGGRLFLTAYVGGDHIVFDPDAPWDQLNNVNPRTLRSVAPELIRPEGRSAIGPDGGIWTGWSAKYGTYGGGLSRIDPATLAVEGWLDPVPGQQVAGVAADAKYVYFTTNGGASGLAHREVQCRFGVWAPGRGLIHEETFEPEQEAGNAIVAIGGNVLIGVGDDIWIFDPDRLAFVHSVPIGHASSWLVAIDDRIAGAYGGGQYWEIDAASGSGVFVSEVPGYVRASVMHDGKLYFAVDSTLYVLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR86</accession>
    <name>A0A398CR86_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglutaminase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01941">
        <property type="protein sequence ID" value="RIE01941"/>
        <property type="gene ID" value="D3H35_14300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013589">
        <property type="entry name" value="Bac_transglu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08379">
        <property type="entry name" value="Bact_transglu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="172"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="288" mass="32376" checksum="AAEE8011E4F9D7C1" modified="2018-12-05" version="1">MKLEIRHTTRYKYGSSVTDSVNEIRLTPRTDERQACYHHRLTIEPNVPLVSYEDFFGNRVHSFTANDPHKELVITSHSTVVTRDRDVTRAAEWGAEESWGRLRTPDFIDANAEYLLPTHYVTLQQKVKEYAAGIGGADEGVFGFIRHAAARVFGDFEYRPLSTGVHTTAEELVGIGSGVCQDFAHLLLAICRLRGVPARYVSGYHFVGDLQGRDADFEQASHAWVEAYVPGVGWQGIDPTNNNLIDWRYVKLGHGRDYMDIVPVKGIYRGTAEQKLHVTVDVQLAETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRE1</accession>
    <name>A0A398CRE1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04720">
        <property type="protein sequence ID" value="RIE04720"/>
        <property type="gene ID" value="D3H35_04345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="81" mass="8687" checksum="D1D36231A360E36F" modified="2018-12-05" version="1">MESSEDEAVGGADTEPEGAGEAAGFPEGEEEGERGDEVAEQAVNSPTDKYIASKYVFRGPLILPPLSTVRCLRSFSNLRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRE2</accession>
    <name>A0A398CRE2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02397">
        <property type="protein sequence ID" value="RIE02397"/>
        <property type="gene ID" value="D3H35_16955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="83"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="345" mass="39163" checksum="8BA8B0D2C28D243B" modified="2018-12-05" version="1">MDDWNRSRRAKNGKFQNEIPVIVKFSAGDIVSMLREFLSAKTQRRPKQPLPIVPLLRGTLSDGKDKIFWFGHSASLLQIGGKTILLDPMLGKNPSPLPFSRNRRFSVKLPITIEELPPIDIVVLSHDHYDHLDSSSIRKLIPKTGTFLVPLGVGKRIRKRGASPDIVIELDWGEEQIVQGIRFTCTPARHFSGRGLFDQDSTLWCSWVIKTEKRSLFYSGDGGYGPHFKRIGRQHGPFELAFMECGQYMECGQYDKRWSGVHMLPEETVQAHRDVQGGVLLPVHWGGFALALHDWNDPARRLSAAAEEQSIPYLLPKIGEAVYLDQIPLSPLREVWWQNPGIRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRM3</accession>
    <name>A0A398CRM3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_02145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05193">
        <property type="protein sequence ID" value="RIE05193"/>
        <property type="gene ID" value="D3H35_02145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="7">
        <location>
            <begin position="122"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="122"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE05193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="223" mass="25601" checksum="3DE0BE71167D55A5" modified="2018-12-05" version="1">MVRVLYVEDDPEIGLWVKDDLERRGYKVEWLTTGEGAAELAKQADLVVLDVMLPGLDGFTVGQRLKKEAPGIPILMLSARTSVDDKLQGLRFADDYLTKPFHPDELVARLEVLQRRYGQLPGKSVKLGHILVHVDRLTVIDSRTNDEIPLTSKQWQILHYFIRHPNQILTKEQIYEAVWEESYIEGDKTIMVHIRHIREKLEIDPGNPAIIETIRGLGYRVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRQ6</accession>
    <name>A0A398CRQ6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_25050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01614">
        <property type="protein sequence ID" value="RIE01614"/>
        <property type="gene ID" value="D3H35_25050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="44"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="298" mass="34163" checksum="C977998A83E3E39D" modified="2018-12-05" version="1">MIECDEIPFFSPEGSIFSASLIPFRKFGILQVFTYKEREMSLYSVLIVEDEDVQREFLRMQIPALDSRFVIAGEAVDGREALDFLSRREVDLLVTDIKMPVMNGLELCREAYAKYPRMRIVILSGYEEFEYARQALKYKAEQYLLKPLAREAMRRVLAQVADHFEQVRSDESALRGLRALSDEGRKQVARRLLQALIAGSQAEIGTLFPLTYRMKIPLFEGEGHLLLLEIDESSLRDKRIGYQETSVFHYILNQIASETAEGCELAWTTFDDRERTAVLLSGTETSELLPECGSFTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS22</accession>
    <name>A0A398CS22_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01734">
        <property type="protein sequence ID" value="RIE01734"/>
        <property type="gene ID" value="D3H35_13070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_5" evidence="1">
        <location>
            <begin position="6"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="144" mass="16218" checksum="F5C97921CB8B8274" modified="2018-12-05" version="1">MAVLAIYATKTGATEQCIKVLAEEISNCTICDIQTEKPAIEHFDSLILGAGVRDGKIYKPIRDFIKKNHQQLLEKKMGYFICNEKPKETEEIFERNIPADLRETAVCMESFGGYKAYAAPKEGTDQLKGIFVDKIKAFSEKFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSC8</accession>
    <name>A0A398CSC8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000004">
        <property type="protein sequence ID" value="RIE05453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05453">
        <property type="protein sequence ID" value="RIE05453"/>
        <property type="gene ID" value="D3H35_00350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="106" mass="11712" checksum="EFF359E45F209563" modified="2018-12-05" version="1">MKRLLRAFKLRQSLLSQYLLIVLAALLLLPLSSPLVSFAPILAVASIGRSAEALYRDGEKLEKMWRSEAAKLEGAADGQVDETLAQLKIEYPARICSGWTRAARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSW3</accession>
    <name>A0A398CSW3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09865</name>
        <name evidence="3" type="ORF">D3H35_09945</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03848">
        <property type="protein sequence ID" value="RIE03848"/>
        <property type="gene ID" value="D3H35_09865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03861">
        <property type="protein sequence ID" value="RIE03861"/>
        <property type="gene ID" value="D3H35_09945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029441">
        <property type="entry name" value="Cass2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14526">
        <property type="entry name" value="Cass2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AraC_E_bind" evidence="1">
        <location>
            <begin position="40"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="200" mass="23188" checksum="5A65BFF0792F7D18" modified="2018-12-05" version="1">MIRGNKFRSLRCYNGVTMTDRGVPERETMRMANQISGASSQPRFMRKERFFLVGAQRYTDNGQASIVQAWDELLERLDEIPDRSEPAVMIGFEDYSRGCELVPGQMPKFHYIAAAEVDRITDVPDGLFSKEVQEAEYAVFSLRGPLSNISGLFRYIYDEWLPASEYRLDPQMMADFEYYREPVNDRNDARVDIYIPIVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTA8</accession>
    <name>A0A398CTA8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldose epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02194">
        <property type="protein sequence ID" value="RIE02194"/>
        <property type="gene ID" value="D3H35_15750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="296" mass="32853" checksum="A3395163D6D24F3F" modified="2018-12-05" version="1">MTNADYSNYSIAVETDGFPIYRLTDRSTDSLVSVCPERGAIVIGCRLNGQELFYLDRATFLDPQANIRGGNPVLFPICGQLIGGQYEWEGQTYGMKNHGVARINPWEVEASGATEDSAYVTVVLRSDEKTLSAYPFDFELRFTYRLKNGVLSIEQNYSNLSDKPMPMVAGFHPYFAAEGKNLPYATDATKYLDYNDNVVKPLADTVDLNGLVESVALLDPVKPEISFPLNGERRVRLSYSEQFRNVVLWSVEGKPFVCVEPWTALNEALNSKEGLLLVGPGESLALELSFACEAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTF8</accession>
    <name>A0A398CTF8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000004">
        <property type="protein sequence ID" value="RIE05450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05450">
        <property type="protein sequence ID" value="RIE05450"/>
        <property type="gene ID" value="D3H35_00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="111" mass="11406" checksum="9D06097FADD32E6B" modified="2018-12-05" version="1">MTGGTMSVGSGESSKISWFYPVCATIERARAAGANWLREVRASVGSAVSVSRQCGSRSAGAPASGSVAGGGFFGLNGLDDWMGFMQKALPMVRMGVDMVKTIMPLLGGLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTI5</accession>
    <name>A0A398CTI5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_16540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03157">
        <property type="protein sequence ID" value="RIE03157"/>
        <property type="gene ID" value="D3H35_16540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="267" mass="28299" checksum="0E28504825D1B756" modified="2018-12-05" version="1">MLAIGVVSAIFGSIVGLGGGIITVPVLVLIGPSLLGEAVSSQTAVGTSLAVLIFTALSATWTYKKQRKVDFASGWLFFSTSGPAAMIGALLTNRIAQGPFQLAFGAFMLVMFGLMVARERMKPLNIRWKITRTFTEGSGREHTYGYSIPLALLIGCGVGLVSGLFGIGGGSLFVPLMVLLFRFPPHIATATSMFVILLSSVLGSGVHAWHGNIDWSLFAALAPGAIVGGRVGAVVASRMSGRQLMWLLRVTLLIMAIYLILKGIREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU54</accession>
    <name>A0A398CU54_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_04895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04809">
        <property type="protein sequence ID" value="RIE04809"/>
        <property type="gene ID" value="D3H35_04895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="108"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="346"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="450"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="552"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="708" mass="82280" checksum="9A9E38243035B7FB" modified="2018-12-05" version="1">MKLAVFVVLIAFLIRGNRMRDSGRRKPFRLFADWRTKRLKPEEKVEYSLLLHESGRTEEALRLLDDVVRSSSFAYAYERRAHIYNELGREEEAIADLDEAIKLNPEPYIVWYTRAIAHNDRGELEEAARDFQEALKRRDDSKASTYYELGNVYMKMNDYEKAEAAYSLSLKDTSKAIPHFYYRLAVVLEQLDRDEEALAAARSAVKLHVQFMKANDRGAAAIKERTNYSTVAVGSFIRSAKEEYGFRLYESGLLERMGKQEDALEAVEQALLEYPNNRELELRKGVLLRQLGKFEASEQLINGIKNMHPSWIPVYMELCTTYRLQEKTEEAVSVLQQAKRRFPDNTVVRYWLADAYREAGKTEEAIEENRSLLEVEPEDPLNWKQRGELAIDADLYEEADEAYSKALELVDSSEYFMRRSFVRYMADRFEDALLDIQSALKRDGSLLQESRTSYAMGELYVGMENWELAEAEYSRAIALEPDNPQIYDRRARCRYASERLPEALEDCDRGLALDPHNAKLLWLRGFISFRLDDFEAALADSLVYTRMLPDDPQGHYNIGLVYNQLDRHDDAIRAFSRTIDLNPFEAQAYLERAKLRYHYSFDRGRAADDLAQWLLYAGGEKTDNDRFALLGELSGFDDEMRDRAKEQFVSTYGIPYPATYHETGHCRGTYSNVLIKLKSIRIDWEEFTCSSRLHRTWKGTALRNTKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUC1</accession>
    <name>A0A398CUC1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02584">
        <property type="protein sequence ID" value="RIE02584"/>
        <property type="gene ID" value="D3H35_18035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="84" mass="10139" checksum="E4F7E743274853E8" modified="2018-12-05" version="1">MRSRVRGGSRFFVRNGGALVGYPADRIYEEVGFIAYYFHWPHDDVMNMDHRERRRWCEEISKINRKLNDEPESKQNVFDVFGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUH7</accession>
    <name>A0A398CUH7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02644">
        <property type="protein sequence ID" value="RIE02644"/>
        <property type="gene ID" value="D3H35_18365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="279" mass="31575" checksum="465DDD174734B9D4" modified="2018-12-05" version="1">MVSGRLAVFTGSTPNIGTTVTAFGTAYRAAALSGKRIGYLCLNLKSAKTHLYLGVGKPEVTLDGIRPELRAGTLTGDKLRQYTYRLPRMEGLHVLFGNMAREQAEYYEPDDIRKLLEASKQAFDLTIADVSAYWDNAATVCAMKEADERFLVTTGHLSHFQEDIQRWTGQVGTMFGIAPDQFQLILLKDMNRITGGFGMKEIRKETGCLSFAEMKLLDSVHLQLDSGRLDEWLATEEHHAAAFDAVADPMLSRLSWNERLLRTERPWLRRLMFHRSRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVP6</accession>
    <name>A0A398CVP6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Urease subunit beta</fullName>
            <ecNumber evidence="2">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Urea amidohydrolase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ureB</name>
        <name evidence="3" type="ORF">D3H35_21185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the urease beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03094">
        <property type="protein sequence ID" value="RIE03094"/>
        <property type="gene ID" value="D3H35_21185"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01954">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="SSF51278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="122" mass="13197" checksum="53E5365D0A797FE3" modified="2018-12-05" version="1">MIPGEIRAQAGELELNEGRKTATVLVTNTGDRPVQVGSHYPFFEVNRALRFDRESAYGMRLNIAAGTAVRFEPGEEKPVELTELGGAKRVFGLNGLTAGAAADELEPGVAERLKAWQKLGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWK1</accession>
    <name>A0A398CWK1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">ybeY</name>
        <name evidence="9" type="ORF">D3H35_06190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04207">
        <property type="protein sequence ID" value="RIE04207"/>
        <property type="gene ID" value="D3H35_06190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="PTHR46986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="188" mass="21308" checksum="EAB355AD8B5C528F" modified="2018-12-05" version="1">MTLSLEWIDEREGGAGEREEAWMELLEKLLRIAGEQEGVTKGIVTLTLTDNEGIRQLNKQFRGLDKPTDVLSFSMLETVEDEPEIRYDDEYETVETDEGDEEDDAEQAEAESTDLSDPFADMIGDIVISVPRAEEQASDYGHSFERELGFLFVHGFLHLIGYDHGDEEQEREMFAKQEAVLAQAGLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXA0</accession>
    <name>A0A398CXA0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_09830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03841">
        <property type="protein sequence ID" value="RIE03841"/>
        <property type="gene ID" value="D3H35_09830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="5">
        <location>
            <begin position="153"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="223" mass="24912" checksum="26169482300508B9" modified="2018-12-05" version="1">MYRVLIADDQRLLREGIQMILQLENDMEVVSLSENGQEACEAVRLYGPDIVLMDIKMPVMDGIEALRTIKRDFPKTIVLMLTTFAEEKHIVDALAAGADGFVLKDMTADRVVEMLRESMKGHVLLPAAIATKLAAKLATLSPQGSNEFDEGALQRNGLIFTDRERKIILLMLQGHSNKQIAISLFMSEGTVRNYVSIIYSKIGTNDRKAAMAFLRELLNDEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXI6</accession>
    <name>A0A398CXI6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_06740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04487">
        <property type="protein sequence ID" value="RIE04487"/>
        <property type="gene ID" value="D3H35_06740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="142" mass="14881" checksum="4B845E6EC1C0BF18" modified="2018-12-05" version="1">MKTIAKSCGNNVACHTNVYFFNPENISIGNNVSIHPMCYIDASGGIEIGSDVSIAHGNTIMSATHAYENVYIPIADQGIVLKKVVIKDNVWLGAKATIVCGVTIHSGSIVGANSVITKDTLPNSIVGGVPAKVIKYRGGEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXU5</accession>
    <name>A0A398CXU5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_08860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04051">
        <property type="protein sequence ID" value="RIE04051"/>
        <property type="gene ID" value="D3H35_08860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="318" mass="36882" checksum="DC4D1A39BB0057DD" modified="2018-12-05" version="1">MIIFLNNRTVTIERCFQLKSIEQIETFLVLAECGSFTETAKRLYRSQPAVTNQIQKLEEMVGASLFKRSGKAVQLTKSGEIYLAYARQMNRLMEEASEQIRKSAKQQVLSVYASIYLSNYYFADILDRFNRDNPKQVMEIYSFCYDDLKRALMEKRTDFAFMPYYSEDENIHDQFDYIELFQEQFQLILPSDHPWASRKLLLGRDLQNEKILLPSSSYFQKIVSEQMELSGVNVTFLQMSNFELIRQAVKSHLGLAFLPSSVVADEIRRGELVVRPVSGLHIRRRNGIIIRKNASLSPIETAFCTIAQNHFQSHAQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY20</accession>
    <name>A0A398CY20_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04121">
        <property type="protein sequence ID" value="RIE04121"/>
        <property type="gene ID" value="D3H35_09270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="69" mass="8246" checksum="8A5A0F917DEA181C" modified="2018-12-05" version="1">MEILLYKKRTRRNQGHARHQNTIPTYPASSSKFDIQEVEHRVTRYRIVGDLFFYVWLLQKGNIAITIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYH1</accession>
    <name>A0A398CYH1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="6">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase II</fullName>
            <shortName evidence="6">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">lspA</name>
        <name evidence="9" type="ORF">D3H35_06620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the peptidase A8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04281">
        <property type="protein sequence ID" value="RIE04281"/>
        <property type="gene ID" value="D3H35_06620"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00855">
        <property type="entry name" value="SPASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="175" mass="19811" checksum="B5FCD63878B24A1F" modified="2018-12-05" version="1">MQRRLWPVWAYYAVALFVFLIDLVSKKIVDKNVELDERIGVLGDFFIITHIRNRGAAFGMLQEQRLFFLLITIAVVSGIVWYMQRSYRTGSPLLLLALGMILGGAVGNFLDRALYGEVVDFLQFNFGSYTFPIFNLADSGICVGVALVVLDALLSWKQENKDNDNGEQPREEQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYI7</accession>
    <name>A0A398CYI7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-layer homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_06675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04291">
        <property type="protein sequence ID" value="RIE04291"/>
        <property type="gene ID" value="D3H35_06675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017255534" evidence="2">
        <location>
            <begin position="33"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="541"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="601"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="670"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="725" mass="76082" checksum="AD58AB69F18A16F0" modified="2018-12-05" version="1">MAFKRKLAVTTLAASMVTASLAGLPLSQKGLAETFGVQVASATAPGLNAPTLKSRLQAIHNQLNNITGGQAAVDALQAAIDDVDDVTLINDIVTKINQKLAADSIAPLTTVPGGEVETLFNLFKGASLAVYDPQLTELESLRTSPAVQSLLLKLDPDNDLTVASIESFILSLETEASSKLVTLGWPGRLALINDTNNTNRKSFLSDVISAAVPAGSTTGVSGFLNEYGISSTLIVNTLFALQDAIDAEAGGVQVSKNAFIKLAAAYFAYKNLSTTAPSTSTSDGSSNPVVSQDPVKKASDAIDDLAKKLEGASEAEKAKLQKDALAKAQEAITTSGSVDLSKSLKKEGDKSSATLDASTATKVIADIQNAAKSLGEKLSTVGVTSPSLDLTLTVNLGTVSEKTSEVTIPKDVLSQVKAADIPNVAVVVNNISVTVPVEQFNDDTSLSISQGDASTVTSITNLPVASNVYDFSLQEGNTPVTQFDKPVLIRLPINDSNLDTDLLTLAKIIEEKLQFYGGRVSGKQLVEARDSFSSYVVVENKVEFNDIASVKSWAGRQIQVVAAKGAIVGKAQGKFAPQDQVTRAEFAKMLISLLDLDNSLAKESFSDVNESDWFAPYVAAASQLGIIYGRTADKFDPSAKISRAEMATMIARALKVTQGLKDVADVEGALKGFSDSADISSALKSGAAFAASNGLIFGSDGKFKPNNNATRAEAAVVLYRTFNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYP7</accession>
    <name>A0A398CYP7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease PH</fullName>
            <shortName evidence="4">RNase PH</shortName>
            <ecNumber evidence="4">2.7.7.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rph</name>
        <name evidence="7" type="ORF">D3H35_08060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)</text>
            <dbReference type="Rhea" id="RHEA:10628"/>
            <dbReference type="Rhea" id="RHEA-COMP:17343"/>
            <dbReference type="Rhea" id="RHEA-COMP:17344"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:173114"/>
            <dbReference type="EC" id="2.7.7.56"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homohexameric ring arranged as a trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.56" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04124">
        <property type="protein sequence ID" value="RIE04124"/>
        <property type="gene ID" value="D3H35_08060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009022">
        <property type="term" value="F:tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11362">
        <property type="entry name" value="RNase_PH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00564">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002381">
        <property type="entry name" value="RNase_PH_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018336">
        <property type="entry name" value="RNase_PH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01966">
        <property type="entry name" value="RNasePH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01277">
        <property type="entry name" value="RIBONUCLEASE_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="RNase_PH" evidence="5">
        <location>
            <begin position="9"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="6">
        <location>
            <begin position="158"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate (substrate) binding" evidence="4">
        <location>
            <begin position="122"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="246" mass="26676" checksum="393896B623D48A3A" modified="2018-12-05" version="1">MRRKAARDLRSFAVTLHPNKYAEGSVLIEAGETKVLCTATIDERVPPFLKGQGKGWITAEYSMLPRATQQRNQRESIKGKPTGRTMEIQRLIGRALRSVVSLEALGERTITIDCDVLQADGGTRTTSITGGFLALALAIHKLSGTVTFNKYPLTDFLASVSVGVFHNEVVLDLNYEEDSKAKVDMNVVMTGSGTFVEVQGTGEDSPFSRSELDGMLGLAEEGILKLVEWQKETLGEAGVRIGGGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYU3</accession>
    <name>A0A398CYU3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04401">
        <property type="protein sequence ID" value="RIE04401"/>
        <property type="gene ID" value="D3H35_07395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="285" mass="30884" checksum="AD946555F9632C97" modified="2018-12-05" version="1">MADIALVTDSTADIPLEIREKYGISMVSLKVLFGNESYLDNIELSPAQFYEKQRSFAGLPTTSQPSPAEFYEHFKRLTDEGKTVISIHLSSALSGTYQSATIAKSMLDDENADVTVIDSRSASYGYGMLVVKAAEMASRGAGKDEIVAEVERLRRELRLFFLVDTLEFLQKGGRIGKASAVLGTLLNIKPILSIDDEGYVTPIEKVRGLKKAMGRIAELIETDLGRASLDVIVALTPGRDEGAKEMAALLKERLNVRSLLFTEIGPVIGTHAGPGTIGLFVTPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZC8</accession>
    <name>A0A398CZC8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotase</fullName>
            <shortName evidence="5">DHOase</shortName>
            <ecNumber evidence="5">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrC</name>
        <name evidence="7" type="ORF">D3H35_06640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04284">
        <property type="protein sequence ID" value="RIE04284"/>
        <property type="gene ID" value="D3H35_06640"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_B">
        <property type="entry name" value="PyrC_classI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="57"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="67"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="329"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="436" mass="47546" checksum="C8584C0CC98A2F0B" modified="2018-12-05" version="1">MTIWILNGLTVDDNEANSGLVKKHLRIEDGKIAEWADGETTPDTTGALTIDASGKLISAGLIDMHVHLREPGFEYKETIASGTRSAAKGGFTTIAPMPNTRPVMDTPETIKYVLDKAATEGVVRVLPYAAITKNELGRELTDFAALKESGAIGFTDDGVGVQNAQMMKNAMALAASLDMPVIAHCEDDTLVEGAAYSEGAFVKKHGLKGIPNESEAIHVGRDILLSEATGVHYHVCHVSTEQSVRLIRLGKSVGVKVTAEVCPHHLLLSDEDIPNATDANWKMNPPLRTPRDVEACIQALEEGTIDIIVTDHAPHSEEEKAREVLRAPFGIVGFETAFPLLYTRFVKTGRWTLSFLLRRMTSDPARVFRLPYGTLAVGAPADVTLIDLENEREVDPATFLTKGRNTPFAGWKLYGWPVLTIVDGQVVWMEENGINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZW2</accession>
    <name>A0A398CZW2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04741">
        <property type="protein sequence ID" value="RIE04741"/>
        <property type="gene ID" value="D3H35_04465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="240" mass="26298" checksum="2F50A4882869A8A9" modified="2018-12-05" version="1">MDNSFMFWNLQRLGASTDAEVVTGITAIASAQQANAEGYCELTTACTAMTPHNITYRKETSHQLCYSARDYAQLPSPIVYPIPTQLALTRIEPESTAAYEQAGYDGGKNFKNLCDRAPAYVGGGLIGGVNVFIFHAPAHADSAERAVAFIACYLQDYYTTNPAPWLLIGDLNVEPKQLAGSKVGISLEDYIISSGQPTHKKGKELDYALTNYPNAIKLKRVHANKRFEYSDHIPIVAVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1H6</accession>
    <name>A0A398D1H6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05351">
        <property type="protein sequence ID" value="RIE05351"/>
        <property type="gene ID" value="D3H35_00740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="103" mass="12262" checksum="E0A11B6E65FF8FC5" modified="2018-12-05" version="1">MFATLVLIFEIAEKSLNPEKYKEIRLERCYSGNWNVRNRFQYISTFDSVKNSPIGAMAYKIRYEDETGFKIYSHNKSKSVFIKRFHFYLKMMPSISKALKNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D2T4</accession>
    <name>A0A398D2T4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05394">
        <property type="protein sequence ID" value="RIE05394"/>
        <property type="gene ID" value="D3H35_01000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="271" mass="30350" checksum="6A7B4429DC9586E2" modified="2018-12-05" version="1">MRIGFYNHTSVVSGAEISMLLTAKNLKNAEPVVFAPEGELGDRARVSGVAFEPISGYRARLTKNPFVLVRHLAGMRREGWRLAKRFKSAEVDIVHANSIRAGLIVSLFGWLHRRLSFGTFATIRRRLDRKSDRFHRETYGQRADLHFRVCQSWHGRRAANAGEGRAQRVELSFATAEEKAKYRRAIREELGASPSARVIAVIGQIAPWKRQMDALIAARFAGWTTAATFKCGSSASRSFARRTKLTQSGCDKWQAGRNGKEKSSSPVFART</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CAS7</accession>
    <name>A0A398CAS7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 4">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">galU</name>
        <name evidence="6" type="ORF">D3H35_29890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 4"/>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00246">
        <property type="protein sequence ID" value="RIE00246"/>
        <property type="gene ID" value="D3H35_29890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01099">
        <property type="entry name" value="galU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="292" mass="32438" checksum="442AE84542A88233" modified="2018-12-05" version="1">MRIRKAIIPAAGLGTRFLPATKAMPKEMLPIIDKPGIQYIVEEAVSSGIEDILIVTGKGKRAIEDHFDSYYELEQNLLQKGKLDLLSEVQKASDLTDIHYIRQKEPRGLGHAIWCARKFIGNEPFAVLLGDDIVQSEVPCLKQMMDVFDTTQSSVLAVKQVPNAEVSRYGIVDPDPAGGDGNRLIKVRGVVEKPSPEKAPSNTAIIGRYILTPAIFDLLETQDTGAGGEIQLTDAIYRLLRQESVYAYNFEGNRYDTGEKLGYLKTIIDFALERPDLKEEVRAYLSEKLGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBJ3</accession>
    <name>A0A398CBJ3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="11 14">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">ruvC</name>
        <name evidence="15" type="ORF">D3H35_27670</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 14">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the RuvC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="11 14"/>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00526">
        <property type="protein sequence ID" value="RIE00526"/>
        <property type="gene ID" value="D3H35_27670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020563">
        <property type="entry name" value="X-over_junc_endoDNase_Mg_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00228">
        <property type="entry name" value="ruvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01321">
        <property type="entry name" value="RUVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE00526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="167" mass="18163" checksum="9337547EEA5F01E0" modified="2018-12-05" version="1">MRVLGIDPGIAIMGFGFIDKIGHKLVPVQYGCIETEAGTLPEVRLKQIYEASCSLLDKYKPDTVAVEKLFFNRNVTTAFSVGQARGVLLLAAAQRGLPIGEYTPMQVKQAVVGYGAAEKKQVQEMVKMFLKLSVVPKPDDVADALAVAVCHAHSYSLNDKLNGAKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBR8</accession>
    <name>A0A398CBR8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00223">
        <property type="protein sequence ID" value="RIE00223"/>
        <property type="gene ID" value="D3H35_29760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="240" mass="27078" checksum="B079318F3950F591" modified="2018-12-05" version="1">MSDPNMLVLNTRMIQNQALENGKKATTDYRDLTMRYKLLFGMLKQLIEIPVAKKILDFHKIHFQYLLIVVTAVENMKPFDDAIEQIQRNLDEYVRQTGLVLAAVRDIPQDPWEGMNKMGLIVLAPALKESPELARTYNDTLDAYEKLTQEALNAATLCADQGRAIEADTRLKAVEILAKLDALKAQGAIDVVLIEAARKKVQFIQLDTMTRIQTTRGNAEDGVKRLQPMVLKAAQAQRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBT9</accession>
    <name>A0A398CBT9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copper amine oxidase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_29870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00243">
        <property type="protein sequence ID" value="RIE00243"/>
        <property type="gene ID" value="D3H35_29870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017412323" evidence="1">
        <location>
            <begin position="25"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="2">
        <location>
            <begin position="29"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="2">
        <location>
            <begin position="57"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="638" mass="70712" checksum="94D9DD7283E7F032" modified="2018-12-05" version="1">MKSKLTAIALVFALIFTFALPAQAAAALDIKLKIGSDQMTVNGKASKITAPYKTGSTVMVPLAVVTKAIGAKLTLKNTKTITLTYQKHTVVVTIGSKAATFDGKKVDLAVAPVNKSNVTMVPTKVIEGLGAKVTINASTKEVRITVAATPATTTGGGTGGGTTGSTINTDAGKSKVGDSYYGWSINYPTGLVLDYQSEDGDAIEFRDVKKEYYLGVFVMEELDALTVEEKRQTLYGYFDKGESLVDKQTVKAAAQTYEKITSKNKEGFYFEYRGIQANGRMYVIIFGKKTANASELSRYTNVLDSFKTTFDASDRTLKNLTKIIAGYKAFKNADYGLSVVLPKEWTANTEDYVYPMYQSKNRFLSVEATSLVEGDTLDAWVKREVERFHNKYVEAYRKDSEPTAITWNGIQAKLYKTSFSNDTTNWASNYSIYAVQGNYRYEITYAFIDGQQADSESLFADILRTLKVDFNFIAQNFGTITDDSDLADVNATVTKTSRKYGYSITLPEQWYGVKKDFEKEEVLYLLDGGNFSIYVVEDVSDFSNFSWAIDEEYRKMVAEEKNMKVVESVTIMIAGAPAKKIVLENSGTDKENPSRSIAYFIWKNGKVYVAEGSYYVANGTEFITKQLETATNSFTFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CC77</accession>
    <name>A0A398CC77_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation protein YjcZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00370">
        <property type="protein sequence ID" value="RIE00370"/>
        <property type="gene ID" value="D3H35_28530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="37" mass="3728" checksum="A3626D06E5A24B73" modified="2018-12-05" version="1">MGYPVAGAGCGTGGGMQAAAFVLVLFVLLVIILRTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCK2</accession>
    <name>A0A398CCK2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type 1 glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_28625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00463">
        <property type="protein sequence ID" value="RIE00463"/>
        <property type="gene ID" value="D3H35_28625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01382">
        <property type="entry name" value="PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="6"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="177" mass="18633" checksum="D159CB6D9CE23480" modified="2018-12-05" version="1">MKQMTKKVAFLLANGFEDSEMKNPYDAMTENGTEAVIIGLERGASLSGKQGTITYTSHLAAHEAKASDYVAIVIPGGQSPAILRDNKSIIDFVREADSLGIPIAAICHGPQVLAAAGLTKGKTLTGYPGIAGELTQAGASFVDREVAEDGNLITSRKPEDEPAFIDAIIRRIGVAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCN0</accession>
    <name>A0A398CCN0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_25690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00956">
        <property type="protein sequence ID" value="RIE00956"/>
        <property type="gene ID" value="D3H35_25690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="171"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="392" mass="42039" checksum="88166F16800FFC73" modified="2018-12-05" version="1">MSASKSIVRSAISGYAPRLKEIAAFIGANPELGHEEKQASALLASELEGLGFIVERGTLGLSTAFVAEYRSAKPGPIVALLAEYDALPEIGHACGHHLICTMALGAAAGVKAVIDETGGTVRVYGTPAEETKGAKVDMATAGLFDDCDAALMAHPFHVFEKSGLSLAMDAWQFEFHGKAAHAAAHPHLGINALDAVIQLFNSVNAMRQQTRSDARIHGIVSSGGEAPNIIPDYAAAQFYVRSLDRRYTNELSQRVVACAEAAALATGCTVTKSNYEYSYDELRTNEPLSEAFTSNLIEAGIPADDILTGHDHGSLDLGNVSLRCPAIHPYIQVVEQPYQLHTIEFRDAAQLERAYEGMAFGATMLAFTAFDLLSDEELLKRVRTAFEAGRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD14</accession>
    <name>A0A398CD14_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000060">
        <property type="protein sequence ID" value="RIE00305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00305">
        <property type="protein sequence ID" value="RIE00305"/>
        <property type="gene ID" value="D3H35_29365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="171" mass="19202" checksum="9A1E4073F78C705D" modified="2018-12-05" version="1" fragment="single">AKALQGYANSGQVLEEAEYWQAVERVEVKPLRKDSEVGAGLMKDGRHVSLTLTEEQTEKLLKQVNKAYNTEINDILLTALGLAIGEWNDSKQAAIELEGHGREEIGHEVDISRTVGWFTTQYPVILEMEQSRELSYQIKTVKEHLRRIPNKGIGYGLLKYGRQLLKGGHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDJ5</accession>
    <name>A0A398CDJ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00773">
        <property type="protein sequence ID" value="RIE00773"/>
        <property type="gene ID" value="D3H35_26640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017270643" evidence="1">
        <location>
            <begin position="31"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="452" mass="49681" checksum="5EF225809500D9AB" modified="2018-12-05" version="1">MTTKTTIYGKWLLAGVLTALPFTIAANVYAAPPQAVSKEAPTKEYELFLKEKLGITLPPAPKKGDFLSALADALKLEPTADSVIFKDLALSSPYYADAKALYQQGFITADSVHAADRLSALNAVQIAVKAAGLQELADTYPKAKVEKAFAKLKLNTADFAARSAQVVAAAVDTGLLPEAFYPELKPKAAASEPLSATLIGKVLTVRGQYKHYIGYVGDPDIFGKLSDAYRSSDIIQSDELQKIVDTALEQNIVTGYNLKDARYDANFVNSLSLTYGHSDLKHALQLIGLLRSEGIDAKVQFEPKTSAFVYLKEWGDPGESDLYEVKQIANGNYIEYAKEYDIAFEFDTAADKERFDQIVLAYAKKNADEQAGLIAGSWWQPLYYSLTELKGYKKITNNKITAGHYYAQSFSLKEQSASVTAGFKKADPSVKVENYDFWTDVPFFNYLNGESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDJ9</accession>
    <name>A0A398CDJ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000053">
        <property type="protein sequence ID" value="RIE00505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00505">
        <property type="protein sequence ID" value="RIE00505"/>
        <property type="gene ID" value="D3H35_28085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="78" mass="8908" checksum="0D557A91356FA8DD" modified="2018-12-05" version="1">MEWKGKARGRRKKYAHYRLYSRRIILILFIAATLRDAEKGEKSAMAIKELPVNPDTAAELAVPPPPTNEQRLPSHRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDL9</accession>
    <name>A0A398CDL9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_26820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00803">
        <property type="protein sequence ID" value="RIE00803"/>
        <property type="gene ID" value="D3H35_26820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017292741" evidence="2">
        <location>
            <begin position="32"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="335" mass="37588" checksum="9E6D5B5694691851" modified="2018-12-05" version="1">MNLFRNQARCTRLFFIAILCAAATGCSLASANGTSSSPATSLPSSSLSSPTASASIPASIEPEAPKPTVPSQVIKTEFYSKHLEKNMRIQIYLPPGYDESADYPVLYMLHGYNGTEKAWLSEMGLNKAADRLIADGLIEPLIIVSPEMDNSYGLNSETKYRIATPEDPVHSRYYGPYEDYLVEDVIAYADETYRTIASKEGRSIGGFSMGGFIALHVAFRHPELFSKAGGHSPALWTDDWSRVPRMKSWLYPTKAERKKRDPIELALTQDLNGLEVYLDCGEQDDFKLYDGTKKLYDNLQSRGVRSEYHLNPGKHDRTYWRSQLDEYLLFYGTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDR6</accession>
    <name>A0A398CDR6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thiol peroxidase</fullName>
            <shortName evidence="4">Tpx</shortName>
            <ecNumber evidence="4">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peroxiredoxin tpx</fullName>
            <shortName evidence="4">Prx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Thioredoxin peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tpx</name>
        <name evidence="6" type="ORF">D3H35_27975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxiredoxin family. Tpx subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00575">
        <property type="protein sequence ID" value="RIE00575"/>
        <property type="gene ID" value="D3H35_27975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03014">
        <property type="entry name" value="PRX_Atyp2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00269">
        <property type="entry name" value="Tpx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002065">
        <property type="entry name" value="TPX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018219">
        <property type="entry name" value="Tpx_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01265">
        <property type="entry name" value="TPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="16"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="4">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="165" mass="17982" checksum="B4EA4AD060B22B8D" modified="2018-12-05" version="1">MATFKGNPITLVGPELKVGDQAPDFKLSKNLLESVSLQDYAGKVKLISVVPSIDTGVCDAQTRRFNEEASKLGDNVIILTVSADLPFAQARWCGAAGVDRVVLLSDYKDNNFGKSYGVLIEEFGLDMRAIFVLDANDKITYVEVLPEMTEHPNYEAAVAAVQQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CER7</accession>
    <name>A0A398CER7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane lipoprotein carrier protein LolA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_25630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00945">
        <property type="protein sequence ID" value="RIE00945"/>
        <property type="gene ID" value="D3H35_25630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017247057" evidence="2">
        <location>
            <begin position="28"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="383" mass="42056" checksum="5E24D4EAFF8B6A72" modified="2018-12-05" version="1">MRRRIPLVVAAVLLLAAVLSACGSKNADSIVKDLDKVKSKMESYEGSGTMTLHTGQQPLTYKVEVRYQKPNFYRIALTNEKRDITQIVLRNGDGVFVLTPSLNKSYRFQSDWPENQGQVYLYQTLLQSILVDNSRQFTTDKDAYIFDVMAGNYQNGSFARQKIWLDKENYAPKQVQVTDTNANVMVDVKFDSFAFDKKFDSLVFDMNENMKQPNSQSSSSGPDASNSPDASQSPSASGKPTDGESSPDPEATAGTNEEPTSGSIDKQPDTVTVSEPDPDALPVGVKQIDGAIDVQLGDSMGVMLRYTGTYDFTILEMASKDRAASLSEGIVLDLGFTYGLLTGTDTKTLTWSYAGVEYRLTTNDLPEEDMVAIAQSMEESSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFP6</accession>
    <name>A0A398CFP6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02016">
        <property type="protein sequence ID" value="RIE02016"/>
        <property type="gene ID" value="D3H35_14720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="1">
        <location>
            <begin position="181"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="370" mass="41939" checksum="1EA7194946ABD84F" modified="2018-12-05" version="1">MPAIGRSSRKPGIPPSPTRRAARLFLLDVSTRIDSLCHNFQYLFKKVRDGDRMREVYVSHLEPGDVLDKPVFARNGVVMLEEGTVLTEPYIQSLKRIGIDRVRLRSRKPGVAWPEDANDRSGETESEYRLPDISALKSDVRAREDAVRLATAFADSDLGLGRMSMPFPVEVFRKQFREIVMGIVSQPAFAEELGVLYLTDRQLFEHSLQVALCSDIIGTIRNFDASRRYALTLGAMFSDIGMTRLPTELLKLPRELKDPERAIIKRHTTDGYRLLTRMKEMPAESAKCALLHHERYQGGGYPLALKNSDIPEYAQIVGLADVYNALLSPRHHRQPYAREEALEYLYAAGNWEFEAQLIRLFLNSVKGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFZ5</accession>
    <name>A0A398CFZ5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase_M23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_15260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02116">
        <property type="protein sequence ID" value="RIE02116"/>
        <property type="gene ID" value="D3H35_15260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017263325" description="Peptidase_M23 domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="4">
        <location>
            <begin position="318"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="177"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="419" mass="46990" checksum="56D8B6B9E55A7CC7" modified="2018-12-05" version="1">MKKKLMWTLAMLIAVTVLARPYDGYAKTESQKLEDEIKQLEKQMNALESSKRKAERDKKKAQSSKQNAQKESEAVSSKKELTLADIDQLNAQIETATAELMETQGNVANAEEELHNIGVELEETTKKKLDQDELFQDRIRLLYKEGAVSYLDVLLSSVSFSDFLERYDAVQSIMLYDKDMLTKIQSYEKQVEEQQAKKDEELENLKDLYAQRADQVASLEDKEQEKEVMIAAYNKQLQDKAQVIAKSNEIIEESEEISEEAERKLTAFAKKMSALEAKKNSIKNYYKGGKLGMPLQANYKLSSPFGYRIHPITGKKKLHAGMDMAVAQGTPIYAAESGVVIVAQAWSGYGNCVIIDHGGGLWTLYGHIKANGILVEKGQTVKRGQKIALVGSTGQSTGPHLHFEVRKNSEPVNPAPYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG07</accession>
    <name>A0A398CG07_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000047">
        <property type="protein sequence ID" value="RIE00852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00852">
        <property type="protein sequence ID" value="RIE00852"/>
        <property type="gene ID" value="D3H35_26120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="117" mass="13319" checksum="F8859F66BFC5C020" modified="2018-12-05" version="1">MLISSYLRTHGSQRQEQASRRGQDVPQLAVQQRDLRQNSESERLLLGYAGSRRTGRVLHRRSELAEYGPRHLLRQYGPVPSPTWIALGNAAQEYTFKGDADKSIDKFITAYNKTKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG14</accession>
    <name>A0A398CG14_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02146">
        <property type="protein sequence ID" value="RIE02146"/>
        <property type="gene ID" value="D3H35_15445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025916">
        <property type="entry name" value="YdjO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14169">
        <property type="entry name" value="YdjO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="75" mass="8627" checksum="D9425A1BA8473CD0" modified="2018-12-05" version="1">MYNRKKISEELPQEETLIWSCVSESCKGWIRDNFAFDTVPTCPLCKSAMEKTTRMLPQLENHGHNQKSPTNGVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGJ7</accession>
    <name>A0A398CGJ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_25030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01610">
        <property type="protein sequence ID" value="RIE01610"/>
        <property type="gene ID" value="D3H35_25030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="26"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="116" mass="12251" checksum="0699DAFE50814B1E" modified="2018-12-05" version="1">MCGSGSARINYPKFVVQCYQIHRTGGKIDVHAQLSGDTVTVSVRDNGVGMEEEQLRRLFGGTPLHSLAGTLGEKGAGLGLLVSRQFVERSGGSLWAESKAGQGSAFYFTMRGGAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGL3</accession>
    <name>A0A398CGL3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_16715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02356">
        <property type="protein sequence ID" value="RIE02356"/>
        <property type="gene ID" value="D3H35_16715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="202"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="436" mass="49307" checksum="2DC7CAE3458FDD9A" modified="2018-12-05" version="1">MRQHRITAAALSTVFMGLGQLYNRQYVKGLSFFVFYVLAIVYAIKNLYHGLWGIITLGETKQKLVLVGKVYQKIPGDHSIFLMIEGLITIFVALLTVYFLIMNILDAYKGGKLREEGKTLSGIADTLKFIVDKKFPHLIITLPLIFVFFFSVLPIIFSVLIAFTNYNRTHEPPGNLVDWQGFRAFKDLLGLSQWAHTFLGVFSWTMIWAVLSTFTTFFGGFAVALLVQQKGIRLKSLFRAIYMVPFAIPSFLSLLIMRNLFNDEVGPINALLLKFGIVGPPWLSDPTWAKATIILVNFWLGFPLSMLLVIGILVTIPRDLYEAAEVDGASAFFKFKSITFPSVMFSLAPIVISQFMGNINNFNVIFLLTNGGPTNSQYQFAGHTDILITWLYGLSVTNARYNFAAVVSIFLFIIIAFFALVSFRRTRSFREDDMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGL8</accession>
    <name>A0A398CGL8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Trans-2-enoyl-CoA reductase [NADH]</fullName>
            <shortName evidence="9">TER</shortName>
            <ecNumber evidence="9">1.3.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">fabV</name>
        <name evidence="12" type="ORF">D3H35_21980</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:18177"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TER reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.44" evidence="9"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01092">
        <property type="protein sequence ID" value="RIE01092"/>
        <property type="gene ID" value="D3H35_21980"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050343">
        <property type="term" value="F:trans-2-enoyl-CoA reductase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01838">
        <property type="entry name" value="FabV_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024906">
        <property type="entry name" value="Eno_Rdtase_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024910">
        <property type="entry name" value="Enoyl-CoA_Rdtase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010758">
        <property type="entry name" value="Trans-2-enoyl-CoA_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37480">
        <property type="entry name" value="PTHR37480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07055">
        <property type="entry name" value="Eno-Rase_FAD_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12242">
        <property type="entry name" value="Eno-Rase_NADH_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12241">
        <property type="entry name" value="Enoyl_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl_reductase" evidence="11">
        <location>
            <begin position="81"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Eno-Rase_FAD_bd" evidence="10">
        <location>
            <begin position="324"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="110"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="138"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="272"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE01092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="397" mass="43170" checksum="9D8B08549A04CBAE" modified="2018-12-05" version="1">MIIKPRTRGFICTTSHPRGCAAQVQEQVDYVKERPPIKGPRNVLVIGASAGYGLAARIAAAFGAGANTVGIYRQGERGGGRTASAGWYNSAAFETAAQEAGLKSFSVTGDAFTDETRAKAIEVIREELGQVDLVVYSVASPRRTDPRTGVTSTSVLKPIGKPYTNKTVNFHTGEVTEITIEPATEEEIQATVAVMGGDDWQLWIDDLQQAGVLADDATTIAYSYIGSQITQAIYREGSIGQAKDHLEATANRLNEQLGATGGRAFVTVSKALVTQSSSAIPVVPLYISALYKVMKEKGLHEGCIEQTYRLFADRLYSGGGEVPVDEKGRIRIDDWELREDVQEEVAKLWNALTTENIAELSDLEGYRREFFQLFGFETDGVDYEADVDPDVTVPNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH67</accession>
    <name>A0A398CH67_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D3H35_15145</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02093">
        <property type="protein sequence ID" value="RIE02093"/>
        <property type="gene ID" value="D3H35_15145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017416842" description="Histidine kinase" evidence="10">
        <location>
            <begin position="40"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="67"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="128"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE02093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="347" mass="38190" checksum="D7F0FD5FD6C89FCE" modified="2018-12-05" version="1">MTLRKKLFLWIGGSATFALLIGLLIGSLWAAPPQDGAKAADSSGMTYLAAVLLLLFTIWAIASMASQQMTARLRSLVRRADRVAREGTLEGADDEPGHDEIAMLADSFNRIAGEWIQGEKLRNQLVSDAAHELRTPIAILRGHLETMWKGAAEIKRENLLSLLDETKRMTRLIQELQQISLAESGQLSLECSWVRFAPLIREVADIFGVEAEEKRIDLTYEDDTPQGFEVYCDAARIKQALINLIGNAIRYTPEQGAIWIRQSVAREGIVQVEVADTGPGIPAEKLPYIFHRFYRVDDSRTRTAGGTGLGLAIAKQFVETHGGTLVASSAEGKGTVFVMRLPVFPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHL8</accession>
    <name>A0A398CHL8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine kinase</fullName>
            <ecNumber evidence="1">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_24370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01492">
        <property type="protein sequence ID" value="RIE01492"/>
        <property type="gene ID" value="D3H35_24370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="121"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="339" mass="36596" checksum="E1AE3E926348EC8B" modified="2018-12-05" version="1">MTRTVREALKLPYASIELQQDDNGESFAVAEDGARQAETVRFALVHRGEPIGHLVVAPRSPGEPFSTSDRRLLDMMVRHASAVVQSAKASLDLKRAAADLRESRERLVVAREEERRRLRSNLHDDLAPRLAALAYTASAAESLLDSDPGKSKTILVELQSVIRSTVTDIRRLVHDLRPPALDELGLIGAIEERIGDLSRPLPTGSSVDAARKPSALQFRLHAPNALPALPAAVEVAAFRIVTEAIVNVVRHAAASSCEVRILYPAPQGDGLALEVIDDGRGIGERSYPSAEPGGIGLPSMRERAEELGGFVRLERAGPNGTRVKAYLPIALHQEGSEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIA1</accession>
    <name>A0A398CIA1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">6-phospho-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_25395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00909">
        <property type="protein sequence ID" value="RIE00909"/>
        <property type="gene ID" value="D3H35_25395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019802">
        <property type="entry name" value="GlycHydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01324">
        <property type="entry name" value="GLYCOSYL_HYDROL_F4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="197"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="437" mass="48102" checksum="D027E6E0CFBADB50" modified="2018-12-05" version="1">MKNENLKVAVIGGGSSYTPELVEGFIRHHRELPVKRLVLVDVEAGREKLEIVGALAKRMVEEANVPIDIELTLDRRKAIKGADFVSTQLRVGLLNARAKDERIPAEYGLIGQETTGAGGFAKALRTIPVILDICRDIRELAPEAFLINFTNPAGIITEAVLKHGGVRTIGLCNLPIGTRMQIAKLFDVDVSKVDVEVVGINHLNWATRVSVEGIDVTEALLSKASGAGGLTMKNIPDFGWDTDFLRSMGALPCSYHRYYYMPEQMLEHQKEQLQQGFTRADRVKQVEAELFELYRDPDLKIKPTQLEQRGGAYYSEAAVNLMTSIYNDRQDIQTVNVRNNGILPCLPNDVSVEVNAVIGANGAQPVQPSKELSPQIRGLLQVVKAYEELTVQAAVHGDESAALQALTIHPLVGSADKAKRLLADILAAHREYLPQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CID1</accession>
    <name>A0A398CID1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF86 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_20820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the HepT RNase toxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03036">
        <property type="protein sequence ID" value="RIE03036"/>
        <property type="gene ID" value="D3H35_20820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="140" mass="15390" checksum="334357218B835CB7" modified="2018-12-05" version="1">MYYVNREGIDSRLNCIPEIVEALAAAASDWRGTLAEGLAQERALHLAAEIVTDIGSALIDGFLMRDASSYEDIIEIIATEQVISPEVSVPLTQLVALRKALVQQYDTWPRRELHPLSAALPALLNDFAIQVRGYLAKELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIM2</accession>
    <name>A0A398CIM2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome (Ubi)quinol oxidase subunit III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_15965</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02230">
        <property type="protein sequence ID" value="RIE02230"/>
        <property type="gene ID" value="D3H35_15965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02863">
        <property type="entry name" value="Ubiquinol_oxidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033946">
        <property type="entry name" value="Ubiquinol_oxase_su3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="PTHR11403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="9">
        <location>
            <begin position="27"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE02230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="205" mass="22818" checksum="9C750E78CF53BFE3" modified="2018-12-05" version="1">MSAHEHVDGQLPHEPERATLEGRNKVLGFWIFLGAETVLFGTLFSAFLALRHNIGDGPAASHLFELPMVFAATMILLFSSLTSVFAVQAMHSNKVKPMIVWLAITILLGLAFLCLEIYEFNTYVSEGHQFRTSAFSSSFYTLVGFHGAHVAFGVLWIGLLIAQIFKKGLTVVTAPKIYVSAIYWHFIDVVWVFIFTVVYLMGKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIQ2</accession>
    <name>A0A398CIQ2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YflT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02613">
        <property type="protein sequence ID" value="RIE02613"/>
        <property type="gene ID" value="D3H35_18190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025889">
        <property type="entry name" value="GSP17M-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11181">
        <property type="entry name" value="YflT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YflT" evidence="1">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="168" mass="17544" checksum="21D75119A25E30A5" modified="2018-12-05" version="1">MAMTIGIFDRESDVAEAIRLLREAGLEQGDIRVVVKNAESARWLVSETDVPIEELTAIRAAGQKESAADGIESDTIVLPAAIMGTTTGTFGYGYVGGAAAYGTIVGGLDGDDEVRTTEILRNIGVSDEAAGQCGVALNEGSYLLLAESGEEAQAEQLLRHAGAKDIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ31</accession>
    <name>A0A398CJ31_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02330">
        <property type="protein sequence ID" value="RIE02330"/>
        <property type="gene ID" value="D3H35_16565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017299212" evidence="1">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="65" mass="6512" checksum="9DD32EFF5218E149" modified="2018-12-05" version="1">MTHSRTSSGNIVKLAAAALVAVQVASFGLGGSASAAESPIVVNVDQIAKQAEWAPVSTGGRCNCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJL1</accession>
    <name>A0A398CJL1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02535">
        <property type="protein sequence ID" value="RIE02535"/>
        <property type="gene ID" value="D3H35_17750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="84" mass="9897" checksum="C6B869606DACAD10" modified="2018-12-05" version="1">MAGSSAQQWYEVPFFRRLAGTGAQQWYEVPFFQRLAGTSAQQWHEVPFFQRMAGTSAQQWHEVPFFQRMAGTGAQQWYEVPFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJS4</accession>
    <name>A0A398CJS4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Magnesium transport protein CorA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">corA</name>
        <name evidence="7" type="ORF">D3H35_11045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mediates influx of magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03566">
        <property type="protein sequence ID" value="RIE03566"/>
        <property type="gene ID" value="D3H35_11045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004488">
        <property type="entry name" value="Mg/Co-transport_prot_CorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00383">
        <property type="entry name" value="corA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="317" mass="37414" checksum="AFFAC6AC5129B8D9" modified="2018-12-05" version="1">MLHILAMTEDLQVLENIEIERLTDKDVKWFWVDFDKPTEEETKLLDSYFHFHPLAIEDSLHLLQRPKVDHYGDTHFFVLHGIEPGDSAKVGEINFFLGPRGIVTIHLEPSAEIEDAWRQMASPDFYSKYDHNYVAYLILDKLVDNYFPMLYRIEDQLNELDDAGSEARVRLEIDQVYDIRSALLRLRKTVIPMRDLLYRIINSDKITGVKEHHAYFTDVYDHLLKLAEMIESNREMTADLRDSYNSRQNNRMNAIMKRLTVITTIFMPLTLIAGIYGMNFRFMPELEWHWGYFAVLGAMGALAWGMYAWFRKKGWFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJT2</accession>
    <name>A0A398CJT2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01108">
        <property type="protein sequence ID" value="RIE01108"/>
        <property type="gene ID" value="D3H35_22080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017251536" evidence="1">
        <location>
            <begin position="33"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="160" mass="17311" checksum="43AEB071701EC9BE" modified="2018-12-05" version="1">MLRKYKWLLAATCTIALVAVGHDLIGVNPATAASEKTVQSSNDLNTEDSINDQANKETLQALLTDHGFPQSAASSLQSSIQSAPAVIGGKSGKTTVTYKVVVTQSSTENNSKPYEVELTKDWNINVNGKDVIGYWKYKVNGDKVTLLIERNNDSAINLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJV5</accession>
    <name>A0A398CJV5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02983">
        <property type="protein sequence ID" value="RIE02983"/>
        <property type="gene ID" value="D3H35_20490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="125" mass="14148" checksum="6A114C71E1C3FA6A" modified="2018-12-05" version="1">MRIVYHASRLLLGIIFITGAVNAVWIHVLGHASFMPLNEKATNLILETHYLYTLVKIFETAGAMLLLLNKYVGLGALILSPVVGNILFMHIVWDPGFVPVALLMVVAEAILIWKFRSRYRVLFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK13</accession>
    <name>A0A398CK13_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_20870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03043">
        <property type="protein sequence ID" value="RIE03043"/>
        <property type="gene ID" value="D3H35_20870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="210" mass="22866" checksum="A07D5684A435D263" modified="2018-12-05" version="1">MERSPEHYFDSLYEEDPDLSRVEQTLSRLGMPAISVAPGYGRLLTWLVSLSGARAVLEIGALGGYSGICLAKGLAEGGRLTSLELRADYAEVARTNVEEAGFKGMAEYMVGDASASLERLHADGRKFDFFFIDADKENYPVYLEWAIKLGNVGAVIAADNTLLRGRTVDPGKMGPSVLAVREFNRLIAQDRRLAGVHLPAYDGLALARIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK16</accession>
    <name>A0A398CK16_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02685">
        <property type="protein sequence ID" value="RIE02685"/>
        <property type="gene ID" value="D3H35_18670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="125" mass="13532" checksum="80B6C195F620F34B" modified="2018-12-05" version="1">MSEENLRQLYGREIVIILKDGTRHFGVLTSCGKSAVVLNGDKEEAAELAAISALDKRKAAQRSRRISRRTRTASADHSESSESSSGSNERPYWGPMGLDGIRASGPDVPSKVVIPLEPIDTVIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK21</accession>
    <name>A0A398CK21_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_24620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01539">
        <property type="protein sequence ID" value="RIE01539"/>
        <property type="gene ID" value="D3H35_24620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="69" mass="8468" checksum="75238FB2E392A9A4" modified="2018-12-05" version="1">MAIKGQKYMHYPESLKLESIRLHVDEGWRWMRKYREDGQAAFEDRRGSPHRAETEQERELKRLYMEVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKI8</accession>
    <name>A0A398CKI8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldose 1-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_28765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00407">
        <property type="protein sequence ID" value="RIE00407"/>
        <property type="gene ID" value="D3H35_28765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="326" mass="36497" checksum="9B1694303D1B591A" modified="2018-12-05" version="1">MSRYSATIREHDGFKIVSLMDSGADAEATIVADAGSNLIRFRQQGCEVLSHPDSLAELKGNGRSKYGTPILFPPNRVKKGIIKFKGREYKLPLNEPPEYHLHGELSSRPWEIIATGVSDKDGAFAITRFRFADHPDIMNYFPHSLVFTMTYKLSDGKMFVEGAIANEGPDEAPFAFGLHPYFNLPFRSHSAISLQVPASVEWPVSNQAFVIGEPSITALCRELRNGITLNDFPQLGVALVELDPAGDRTCKIVVNDEAKRYTIAYRMDESFPYVVLFRPDWSDAFSLEPYTYVTDAFNLDYAYERTGARGIRSAETISFATSLWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKK6</accession>
    <name>A0A398CKK6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00427">
        <property type="protein sequence ID" value="RIE00427"/>
        <property type="gene ID" value="D3H35_28885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017446500" evidence="1">
        <location>
            <begin position="25"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="375" mass="40930" checksum="7C6292591CAF89D7" modified="2018-12-05" version="1">MKKIKLTLFVALCVSLLPAVGVSAEKKSANEIERGLAEIINEELNYNGYSSLSTSDFNKSDADFDQLITEKKVDSKIKDRIKKLKNAEYVSLTFDEDGILTEAQSNKSGNVVERFKHENPNKNKVSNKNEVRISSLLTDTSPKPVGASSGAFHRIKTPESTSLSASFTGAVADGIVLPTVDINNSYLTGESSNLYIGIDSATNGYAEVGLVTAKSLSLAAGWYPGFHAKGTHTLNSGHNSNSGGGYYYDVNRPMTPGTDIGFFKVYYKYDEATLRVRYLLGATTVYDVSFTGVNSTGKSVKRLTTIAMNSSATDTTKFSNSWTSYASWKNFRFLTNNGSSTTYWETVTGIKSETWSHGGSIDYTKSGTTESYKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKQ5</accession>
    <name>A0A398CKQ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02880">
        <property type="protein sequence ID" value="RIE02880"/>
        <property type="gene ID" value="D3H35_19865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="62" mass="7115" checksum="4FD79C8991C7BF4B" modified="2018-12-05" version="1">MWTVIYIAPTAKIAERIQKRLTEEGFLVRVRPINLTKPQYEILVPSGEVQEVQEVLGSILHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKS4</accession>
    <name>A0A398CKS4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000054">
        <property type="protein sequence ID" value="RIE00487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00487">
        <property type="protein sequence ID" value="RIE00487"/>
        <property type="gene ID" value="D3H35_28125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="His_kinase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="66" mass="7674" checksum="F7F91EA245EE6694" modified="2018-12-05" version="1">MEHGRQPYGQSNSFARRRVLPRENFVLQQSELKALQAQINPHFLYNTLESINWMAKMNGLTPSAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKS5</accession>
    <name>A0A398CKS5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YycH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01478">
        <property type="protein sequence ID" value="RIE01478"/>
        <property type="gene ID" value="D3H35_24295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009996">
        <property type="entry name" value="YycH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042274">
        <property type="entry name" value="YycH/YycI_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07435">
        <property type="entry name" value="YycH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YycH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="446" mass="50243" checksum="4DE7DBCE757705D8" modified="2018-12-05" version="1">MMDKLKSVLLAALVMVSMIQSYFLAYNMPNMKAKVNTEQDYVKTEPLGAEEDAKNLIFPEMLVLHMGGDKHTVFYPNKTFYKEILGKLQGREFKGFQRDSVGVVDWNEVRREDNGIELRFGRPVPFDLLRKVFKIDGDFLFSRDSVDRIWIFSRADREEVRTFFFSADGRSVYESLRADLTVGDVTQVVGFGQYGLSYSTGDGEVYIPDKPYDGVPQMQVPITRFTPEQMQRNLFFDAAITRTAQGNQEDTQIYTDGKKLLLVGQNGGWMGYSDPAAPADAVNDLVDNFMAAVQFVNQHGGWNGTYRLTQAPVPDTLNGATSEDNVIRFQQYYGKVPLVSSGSMTFGYMQLTMQQGAVSSYERSLLQLDMNTQTNKKVRLLPGGNDLRQLINRAAGGERIEALYPAYRPSEAKDVITLYPVWVIRLASGEERIVTESGPVQTKTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL48</accession>
    <name>A0A398CL48_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RibD_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03383">
        <property type="protein sequence ID" value="RIE03383"/>
        <property type="gene ID" value="D3H35_11945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="5"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="189" mass="20858" checksum="5A6C848162936C04" modified="2018-12-05" version="1">MRVRKLVAGLFITLDGIVDSPANSPKKWSNAEMAERIAAGVAQADTVLLGPRTYRLLAQFWQHQSDDIPMACFLNRSRKYVVSHTPDNLEWQPATLIQGNLAEEVAKLKEQPGKNIQIPGSPRLVRSLLRLGMLDELNLNICPVVAGTGLRLFDDLDSPLPLQLVDARTYTNGVLGVSYRLVRLTGGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL79</accession>
    <name>A0A398CL79_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-L-AF_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_28670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00391">
        <property type="protein sequence ID" value="RIE00391"/>
        <property type="gene ID" value="D3H35_28670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-AF_C" evidence="3">
        <location>
            <begin position="40"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="210" mass="23822" checksum="9530D3825A1E59EE" modified="2018-12-05" version="1">MDVRKRKFLRSVPQEYQGVRRRVCGTSQQRHEYAGIEQLGCGSGGSRLHDGLERNADVIVLASYAPLFARLRYAQWSPNMIWFDGERSYASPSYYIQKLYSTQIGTHLLQTIADTEEIPFVVSYDREAGALFIKLANPLDRNVSVKIESDFSLADQGEVQVIQADEEEVNSIESPRRVAPITSAFACFDGMEYEVGAKSFHVLKIFRKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLH3</accession>
    <name>A0A398CLH3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03082">
        <property type="protein sequence ID" value="RIE03082"/>
        <property type="gene ID" value="D3H35_21100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="116" mass="12954" checksum="87609605243898B4" modified="2018-12-05" version="1">MSNRFAYRAFQMLLILVCLFAIAALRLAWVQLGSGRGRAEPSASIARQAVLEHSDELVIDTGRGRFLDRNGYLLTDRTVNGLVAFPTGGMQEARRLRSINWRCFGNDGRELIQLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLR8</accession>
    <name>A0A398CLR8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn-dependent protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_27580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00591">
        <property type="protein sequence ID" value="RIE00591"/>
        <property type="gene ID" value="D3H35_27580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="8">
        <location>
            <begin position="13"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE00591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="273" mass="30790" checksum="8160EC199C12E6C1" modified="2018-12-05" version="1">MLASLLTGRFVELVTLFFIVLFHELGHLAMALRFGWTVREVKLLPFGGVVEVEEAGSVPAREELAVALAGPAQNVFLAGVGWALGHLGWVDSLWAEHFVRANVLIGLFNFLPILPLDGGRIAQAWISLRVPYHRTLLWSARISLLFSVLVVLYAVYPLLRGDLLQLNLLAVGLFLCFSNWTYLRNVPFVFLRFLVHRNRRSEVRFDQGTLARPIVIGDDGSLSLVVRLFMKESYHLVYVMKQGRIANVVPEKTVLDRFLGRLSSGNADLRFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLW4</accession>
    <name>A0A398CLW4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c biogenesis protein CcdC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02209">
        <property type="protein sequence ID" value="RIE02209"/>
        <property type="gene ID" value="D3H35_15840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031306">
        <property type="entry name" value="CcdC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39164">
        <property type="entry name" value="PTHR39164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07301">
        <property type="entry name" value="DUF1453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021441">
        <property type="entry name" value="DUF1453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="155" mass="17717" checksum="CD166DDBC2B00C7F" modified="2018-12-05" version="1">MGNSFYVTFILIAALVLWRRTRSFYRPIKGDGRRILLPVLFMLPGIALVLNKDVHAPAYEWLVACAIGVALSIPLIWTTEYEVREDKQIYAKKNVGFIVAFVAVLAIRFALRSYLQMIDPQTLSALFMVVAFSYVLPWRIVSFVKFRRTALLQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM50</accession>
    <name>A0A398CM50_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04426">
        <property type="protein sequence ID" value="RIE04426"/>
        <property type="gene ID" value="D3H35_07530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="121" mass="12793" checksum="95888686271CC9BB" modified="2018-12-05" version="1">MNEWYFDRFGQAMFVIAEGDRFVSRNGRNLGWLKDKSVYTLTGRPVAWLDNGVMRDGSGNIVAFARSAAGVLPSVPGMSGAPGTPSLPGRPPLPGFAGTMSNPGGGGWGSKTIRELFGTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM90</accession>
    <name>A0A398CM90_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_11040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03565">
        <property type="protein sequence ID" value="RIE03565"/>
        <property type="gene ID" value="D3H35_11040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="347" mass="38343" checksum="0D118C15F05C1D97" modified="2018-12-05" version="1">MPSSMFRWSIHLLTIGCLFMLYLIFTGQKIGSLTPLPSISADQWQSLKTVFVSIFLEALPFILLGVLVSSALNLFVSEDALRRVMPKNPVLAIVVACLFGILLPVCECGMIPIVRRLIRKGMPVYVGIAYILAAPIINPVTFFATYTAFRGQPDMAWERVAVGFAVALSLGLILYKSVKKNPLRVDAHHHHDHRDEHAHVHNHNHDHGRKGSRLLDVFTHASDEFFEMGKFLLIGAFLTAVIQTFVSRADLVDLGGGALGPHLLMMGFAYLISLCSTSDAFIASSFNGMFPKSALLTFLVFGPMLDFKNTLMMLAAFRTRFVLKLSLLIVVAVPVASIVLSRTLFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMI4</accession>
    <name>A0A398CMI4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_22075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01107">
        <property type="protein sequence ID" value="RIE01107"/>
        <property type="gene ID" value="D3H35_22075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="72"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="279" mass="31133" checksum="DC396368D5F34D6A" modified="2018-12-05" version="1">MKKSGYTSKTTRLFIYLLLGAVAVSSLYPILWIVLSSLSPGSTLYSASLIPDRVTFVHYKTLFLDSPFTLWYWNTLKIALMTMTLSVLLIVLGAYSFSQFRFKGRQFFLTTMLVLQIFPPFMTMIAVFLLLYQVNLLDSHLGMVLVYTGVAIPYGTWLMKGYMDGIPRSVPEAAKIDGASHFVIFARIMLPMTTPALIFISLTNFTAPWMDFILARLVLHSADKKTLALGLFDMVKDKAASEFTTFAAGSVMVAIPIALLYLYLQKYIVNGVTEGASKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMN7</accession>
    <name>A0A398CMN7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_29535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00184">
        <property type="protein sequence ID" value="RIE00184"/>
        <property type="gene ID" value="D3H35_29535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032109">
        <property type="entry name" value="Big_3_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025883">
        <property type="entry name" value="Cadherin-like_b_sandwich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16640">
        <property type="entry name" value="Big_3_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12733">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="806"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="870"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="932"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="989" mass="105249" checksum="7F87A77F44F20800" modified="2018-12-05" version="1">MRNLEEWTVRKSSLLTRKGLYTKCFLILVITYGSVFFSGEAYAANPVSVSLTGNAVTIAYGQSVTLSSTVTDTLGGSNSPVGTVTFVDNGTTIQTAQPLIEQTPEIIVEASPPGIIPSGYKQACMIDGRDNNPVGSPTCPVLKWGEYTFWGYSDTNNMGIFNIVQYNKEGVIINQDIFQSETRYLYKIELDNTNHTVSFVGQSEKRITVSINSLKAANSIASITTPPLSVGVHEFKAEFNSSDGNHDNEVSSTFKVNVSQITPSVSLTSSVPSSAYGERVSFEAEAPSVSGLVPSGDVIFYDGNVELGAVTLGNSGVTSAVYETSSLTPGVHMITVRYSGDNNFESRTSLPLTYTVNRIAANLSLTSSSSQLSYGSGVMFMVHVPAINLVPVTGTVTFKDGATLLCNVPIGTDGTAQCSAPLLLAGSHTITASYSGDSHYTDSTKSMLQTVNKIGSQINLNGLPSTVAVGDSVSVDVQVDTLGNVMPSGTVDIIIDDQTVSSPELEANASIHLNIPQLSVGSHKIEAAYRGTDNIESSVSTAQVINVLNNNADLSGIALSSGKLSPVFSTSITSYSANVANHVSSIVVTPNVYDSNATMTVNGAQVSNGQANKTINLSVGSNTITIVVKAQDGTLNTYSILVTREQESSSSGSDSSSTASNDTVISTDGTLKLPVNKTGLVSLGDSVQISIPANATDKELILTIEKLTDSLKLITKNDVLASPIFEILKNFSENFSNEISMTFAFDPNSLTDDQEPFVFYYDESKQVWVKVGGEVNGNTITVRVNHFTKFAVFGVGQASDPTSNTKQPTSFSDISGHWAEDNIKQAVSAGIVSGYQDGTFKPNRAVTRAEFAVMLMNALKPQGDEATLTFADKSKIGTWAQKSVMQAVYAGIITGYEDNMFRPDAEITRPEMATIIAKAMAQTVEEKIATGFVDDNYIPDWAKGAVAFMKNLGIIQGKGTNQFAPNDKTTRAEAVTVLLRMVEQRAART</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMS0</accession>
    <name>A0A398CMS0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 5">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rfbB</name>
        <name evidence="7" type="ORF">D3H35_15110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 5"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02088">
        <property type="protein sequence ID" value="RIE02088"/>
        <property type="gene ID" value="D3H35_15110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="6">
        <location>
            <begin position="4"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="338" mass="38235" checksum="0C90B91E3D03F835" modified="2018-12-05" version="1">MRLLVTGGAGFIGSNFISYMLTKYPTYEIVNLDALTYAGNLDNLKAVESNSRYRFIRGDIGDRRVVEDIFASGVDTVVHFAAESHVDRSIKEPDLFVRTNVLGTQTLLEAARKYKAAKFIHVSTDEVYGTLGETGLFSESTPLAPNSPYSASKAGSDLMVRAYYETYGLPINMTRCSNNYGPYQFPEKLIPLMIANALNDMPLPVYGDGLNIRDWLYVEDHCNAIDLVIHQGVNGEVYNIGGSNERTNIQIVRTILNQLGKPESLISYVRDRPGHDRRYGIDATKIRSELGWTPKHNFESGIKETINWYLGNREWWERVRSGEYRQYDERQYGKGLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMV1</accession>
    <name>A0A398CMV1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">QacE family quaternary ammonium compound efflux SMR transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_15275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02118">
        <property type="protein sequence ID" value="RIE02118"/>
        <property type="gene ID" value="D3H35_15275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="113" mass="12147" checksum="DFD0524D0640258C" modified="2018-12-05" version="1">MNRYWLWLVVAGLSEIGWVSGLKHASNVWEWALTLIAIAFSFWTLLAVSKILPVGTVYAVFTGIGAAGTVLSEALLFHSTLEPAKLTLVILLIIGIGGLKMTTSKTASDEEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN56</accession>
    <name>A0A398CN56_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3 7">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">leuA</name>
        <name evidence="9" type="ORF">D3H35_10245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3 7"/>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03670">
        <property type="protein sequence ID" value="RIE03670"/>
        <property type="gene ID" value="D3H35_10245"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01025">
        <property type="entry name" value="LeuA_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005671">
        <property type="entry name" value="LeuA_bact_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00973">
        <property type="entry name" value="leuA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="517" mass="56292" checksum="98F6C56637CD4729" modified="2018-12-05" version="1">MRKIYIFDTTLRDGEQSPGVNLNTQEKVEIALQLEKLGVDRIEAGFPAASPGDLAAVNAVARAVKNATVIGLARSREQDIDAVREAVKGAQDPGIHLFLATSPIHRKHKLRMEKEQVLETADRMIRYAKQYFDKVEFSPEDAGRTELDFLCQVTELAIKAGATVVNIPDTVGYLTPYEYGNIFKTLKENVPGIETIQLSAHCHDDLGMATANALAAILNGADQIEGTINGIGERAGNTALEEVALALETRSDYFQAKTTLNLKEIAKTSRLVSKLTGMPVPGNKAIVGANAFAHESGIHQDGMLKEKTTYEIISPDTIGLKDSKLVLGKHSGRHAFREKLVDLGYESLNEEQVNAAFGKFKDLADRKKTVSDEDIRALLEEKLTETPEIYALEQLTVAFDSHETPSATVRLKIADRGIVEKQSKGNGSVDAIYQAIDALAAEAVELDDYSIKSVTDGTDALGEVHVVLKQGELSAQGRGVSTDILEASARAYVDALNRLVDKRKAPARGRRDNMTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNA7</accession>
    <name>A0A398CNA7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribose ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_28700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00394">
        <property type="protein sequence ID" value="RIE00394"/>
        <property type="gene ID" value="D3H35_28700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017268144" evidence="1">
        <location>
            <begin position="32"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="50"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="353" mass="38559" checksum="4E0874A054811592" modified="2018-12-05" version="1">MAMSKKRVWFTASLLVVVLLFLAACGKDTQGNESSTASGETKSDGYVIVWSPLYQGNSHQAQSLANIQEAVKNNPKIKELIVANPDGNVETQINLIRNAIDKKADAIIIQAVSETALVPVLEEAVEAGVVVINQDSLIKSDKMTSKVYVDDTEWSRITGEWLVDKLGKKGKVVVLNGLAGNTTNRDRWENAEKVLKGTEGIEVLAETNADWAQAKAQSAVASWLAAYPQIDGVWSQGGEMTSGAILEFEKANRPMVPMVGEAYNGFLKLWAKHKDKGFSSIAPALPNYNVLISLEVALRALEGKEVPKNVLVPLPMVTDETLSNYVQPDKADDYWVFDKLAAEEIDKIITDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNB6</accession>
    <name>A0A398CNB6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_09170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04103">
        <property type="protein sequence ID" value="RIE04103"/>
        <property type="gene ID" value="D3H35_09170"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="PTHR43078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="4"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="325" mass="36167" checksum="14582ABBB663721F" modified="2018-12-05" version="1">MRILVTGGAGFIGSHLVDALIEQGHEVVVLDDLSNGKREFIAGLEENPRFRFVQGSILDRPLVRQLLAECEIVYHLAAVLGVKNTVENPLKVIEGNIDGTRNILEIAWENRVKVIFASTSEIYGKNNELPFTEQSDRVLGPPHIHRWCYATAKALDEHICFAYADKGLPVTIVRFFNTYGPRQTSTQYGGVVPKFIVAALGRHDITVYGSGEQTRCFTFIDDVIGGLLPCMDPAFDKHAFNIGTTYRLTINELAAQIKRLTDSASSIVHIPYEAAYGPGYEDMQNRLPDISKAEGMLGYSPRTNMEQGLSKTIAWYKDNEGWRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNF5</accession>
    <name>A0A398CNF5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_16120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02258">
        <property type="protein sequence ID" value="RIE02258"/>
        <property type="gene ID" value="D3H35_16120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="136"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="352" mass="38686" checksum="2CC51B6385FB7412" modified="2018-12-05" version="1">MASLRIGVIGTGSISELHLNAYSANPSASLVAVCDINGQRASDVAAKYGAGKIYTDYREMLADPNIDAVSVCTWNNTHAPISIAALDAGKHVLVEKPLCRTVEEALAIEQAVRRSSKLLQVGFVRRYDPNVAMLRRFIDDGEFGKLYFAKASTIRRLGNPGGWFSDTERSGGGPLIDIGVHIIDLCWYLMGRPKATTVSANTYRQLGNRAHIENLSFYKAADYDASKNTVEDLANAIIRFENGASLMVDVSFTLHAKKDESVVRLYGDKGGFEIDPEIAIVTEKHNTILNIEPQTDYSRLNIQAAFQNEIDHFVRCALTGETPISPVEDGVAIMRILRSIYESAEKGEEIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNI0</accession>
    <name>A0A398CNI0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">HPr kinase/phosphorylase</fullName>
            <shortName evidence="11">HPrK/P</shortName>
            <ecNumber evidence="11">2.7.11.-</ecNumber>
            <ecNumber evidence="11">2.7.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">HPr(Ser) kinase/phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hprK</name>
        <name evidence="14" type="ORF">D3H35_05930</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[HPr protein]-L-serine + ATP = [HPr protein]-O-phospho-L-serine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46600"/>
            <dbReference type="Rhea" id="RHEA-COMP:11602"/>
            <dbReference type="Rhea" id="RHEA-COMP:11603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>[HPr protein]-O-phospho-L-serine + H(+) + phosphate = [HPr protein]-L-serine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:46604"/>
            <dbReference type="Rhea" id="RHEA-COMP:11602"/>
            <dbReference type="Rhea" id="RHEA-COMP:11603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The Walker A ATP-binding motif also binds Pi and PPi.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the HPrK/P family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="11"/>
    <dbReference type="EC" id="2.7.4.-" evidence="11"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04163">
        <property type="protein sequence ID" value="RIE04163"/>
        <property type="gene ID" value="D3H35_05930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01918">
        <property type="entry name" value="HprK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01249">
        <property type="entry name" value="HPr_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003755">
        <property type="entry name" value="HPr(Ser)_kin/Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011104">
        <property type="entry name" value="Hpr_kin/Pase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011126">
        <property type="entry name" value="Hpr_kin/Pase_Hpr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30305:SF1">
        <property type="entry name" value="PTHR30305:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07475">
        <property type="entry name" value="Hpr_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02603">
        <property type="entry name" value="Hpr_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00679">
        <property type="entry name" value="hpr-ser"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hpr_kinase_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Hpr_kinase_C" evidence="13">
        <location>
            <begin position="130"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for the catalytic mechanism of both phosphorylation and dephosphorylation" evidence="11">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for the catalytic mechanism of dephosphorylation" evidence="11">
        <location>
            <begin position="264"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity" evidence="11">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="153"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE04163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="305" mass="34677" checksum="B2275F337CBB9821" modified="2018-12-05" version="1">MKSIPVQSLVDRFQLEVLAGEERLDRSITRSRSHRPGLEFVGYFDFFPMERVQVLGRKEINYLHKQTAEERKLHIGNVVKYHPPCFIVTTNQDGLKYLMKFCQEEGIPLLRTAETTTEFIAKLDAYLIKELAPEISVHGVCLNVSGIGILLRGKSGIGKSETAHTLIRRGHRLVADDIVVLKKLSPHTLLGSHNGVTKEFLALRSIGLVNVVRLYGRKAFQDETRIVLDIELCPWKDQALNNDLELEAKYTEYLGVRIPHIEIQLQPGRDVAGMIEAAANNWYLKQQGYSAAEEFMKRLEGEIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNK9</accession>
    <name>A0A398CNK9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">addB</name>
        <name evidence="8" type="ORF">D3H35_06115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04193">
        <property type="protein sequence ID" value="RIE04193"/>
        <property type="gene ID" value="D3H35_06115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014140">
        <property type="entry name" value="DNA_helicase_suAddB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02773">
        <property type="entry name" value="addB_Gpos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="7">
        <location>
            <begin position="270"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1176" mass="130773" checksum="C6857AED2ED92377" modified="2018-12-05" version="1">MSLRLVTGRSGSGKTRFILDEIRAKLAEDPQGSPLVLLVPEQATFQAEYAMANTPGLGGFMRAQVLSFRRLAFRIMQETGGSAVVPIHENGKAMLLHKVLEDRREELKLFRGGSNETGLIARMGELFTELKRYGVDGAGLSHAARDARSESSLLKDKLHDLSLLYAETERELDGKWLDGEDMLGRLSDGALASAWLAEAEIWVDGFHGFTPNEYSVIRSLLRRSKRVTVALCADRPYLAGDRPDEMNAFHPTAETSAKLCELAAESGVATDASVHLNPVIFPRFARSRMLAFLEKEWTTRVRWTEETAVLHPDHPDCGISLHAAAGRRAEADAAARDMLRRVREEGFRYRDMAVFVRQMEDYADLLAGVFDSYGIPYYLDGKAGISHHPLSEFVRSALECVTGSWKSEAVFRCAKTDLLGAKGAGLSRDEIDKLENYALAAGIDGWRWNDDRVWRPLFTGDIEQEIEEDREAGDSRMAELLRVRDALVGPLRALEKRLKSAKTVRALCEGLYSFLEETGAADSLERWSREDAEAGQPGRAAAHRPIWDGVMNLLDQLVELTGDLKPDLKLFAGMVDSGLEELKLGAVPPSLDGVLIGSPERTRSDRVSVVYLLGVNDGVMPKRMAENGLLSEEERDALALSGLEMAPGARRRLLDERFLAYLALTAASRHLWIGYPIADNDGKSLLPSEWIGRIQRKFPGMPIRMEAAEPQDGDGEDAQLSFAVHPGRAMTHLLARLRRWRQGDSIAPGWWSVYEWLRERGEWKDRIGQLLRSLHFTNVEPPLAPETSRLLYGDRLLASVSRMERFVSCPFRHFASNGLRLRERQLYRVDAPDIGQLFHAALRQTTERLFADANASPTMEQLRLEAAASVERLLPKVQQQILLSSSRHAVMARKLRAIVAQAAGILGGHAELAAFRPVGLELDFGPTGALPPLSLELGGGRWMDVAGRIDRVDAAQSPEGLLLRVMDYKSSGMKLKLDEVSYGLSLQMLTYLDVVVTHAPHWLGQTAAPAGVLYFHVHNPLLHTANGMSQEEANDRLFREFRMQGLLLADGEAVKLMDDSLDGGGAKSAVVPVEFKKDGSFSARSQVAEPAQWDILRKSVRRQIRGIGKRIVEGDVSIKPYRMERKSPCTFCEYKAVCQFDLELEGNEFKTLAKAANRDELWRRLEDQAGEGGMPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNS4</accession>
    <name>A0A398CNS4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">rsmH</name>
        <name evidence="7" type="ORF">D3H35_06450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04253">
        <property type="protein sequence ID" value="RIE04253"/>
        <property type="gene ID" value="D3H35_06450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="32"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="317" mass="34275" checksum="BAAFC2E789DB7435" modified="2018-12-05" version="1">MFHHITVLLEEAVEGLNVKPDGIYVDCTLGGAGHSSLIASKLGPGGRLIALDQDDAALANAREKLAPWADSVTLVKSNFRYLKQALREAGVPEVDGTPRVDGVLFDLGVSSPQLDEADRGFSYNHDAPLDMRMDREGPLTARDIVNEWDEKEITQIIRDYGEEKFARSIARKIEGARAKGPIETTGQLVDIIKSAIPAAARRTGPHPAKRTFQALRIAVNDELGAVKEALAQTIDVLNPGGRASVITFHSLEDRIAKTAFAAEVASCSCPTDFPICVCGGGDGRLRLTPRKPIVPSERELADNPRARSAKLRIAEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNT0</accession>
    <name>A0A398CNT0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_08520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03992">
        <property type="protein sequence ID" value="RIE03992"/>
        <property type="gene ID" value="D3H35_08520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="40"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="73"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="286" mass="32015" checksum="D5FF7269E583F572" modified="2018-12-05" version="1">MIVSIQVTIKSAKRVVEIAEEPEERKNGNVYAEENDGRMVEFKKVSFSYEEREPALIDFDAVLQKNKITALVGPSGCGKSTVTKLLCGFYEDYEGLISIFGGELKQWDIREARARVSVVSQDSFLFPCSVFENISYGNLNATRDEVIEAARMAHADEFIREWPLGYDTMVGERGATLSGGQRQRLAIARAFLKNAPILVLDEPTSALDAHAEAQVQAALERLVANRTVLVIAHRLSTIMEADEIIVMNKGRAVSRGTHRELLQTNQWYRELCEKQNVFSLAEGVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNT3</accession>
    <name>A0A398CNT3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02388">
        <property type="protein sequence ID" value="RIE02388"/>
        <property type="gene ID" value="D3H35_16885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="97" mass="10442" checksum="89074E1E73C6BA8C" modified="2018-12-05" version="1">MGALFGGERGRWAWIVTVGALFDGEQGRWARIVTVGALFGGERGRWAWIVTESALFGGERGGVRELGEHPSAPFALPIAVIGKGFPKVTKVLFRSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNW1</accession>
    <name>A0A398CNW1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4256 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02428">
        <property type="protein sequence ID" value="RIE02428"/>
        <property type="gene ID" value="D3H35_17135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025352">
        <property type="entry name" value="DUF4256"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14066">
        <property type="entry name" value="DUF4256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="191" mass="21971" checksum="CFCD5408C6CFF017" modified="2018-12-05" version="1">MTKNESNIEQLSPEQSEDLLKTLKARFEKNRNRHQGVEWANVLAKLEAHNDKLWSLHEMERTGGEPDVVDYDAKTGEYIFYDCSAESPKGRRSICYDRAALDSRKEHKPQNNAIEMAAFMGIEVLTEEQYRELQKLGSFDLKTSSWVKTPANIRKLGGAIFCDCRYDTVFMYHNGAESYYAARGFRGSLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNY8</accession>
    <name>A0A398CNY8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Elongation factor G-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_24955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01597">
        <property type="protein sequence ID" value="RIE01597"/>
        <property type="gene ID" value="D3H35_24955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032330">
        <property type="entry name" value="EF-G-binding_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010841">
        <property type="entry name" value="EF-G-binding_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038344">
        <property type="entry name" value="EF-G_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07299">
        <property type="entry name" value="EF-G-binding_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16571">
        <property type="entry name" value="FBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-G-binding_N" evidence="1">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="FBP_C" evidence="2">
        <location>
            <begin position="101"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="218" mass="25080" checksum="1636230A1BCFD14C" modified="2018-12-05" version="1">MCEPFIRNHEYNFIKKQADYVLYALRTVGDPKVLESVRLNAQAKVAELFPDLRDHRRTMLESISDLRTAEDFQKYLQALEPYLIEFPAITNKQIQKLFPKNKKLKLPDLAQVDFRYVSYLSWIDISTNKMFIVYPAAGGQFVGLEGRFTANNKKSYCFACNRIEELALFSAVSKKRPANASPDYYKSVGNYICMNGHECNKNMTDVSSLEKFIDSVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP17</accession>
    <name>A0A398CP17_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02498">
        <property type="protein sequence ID" value="RIE02498"/>
        <property type="gene ID" value="D3H35_17555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043737">
        <property type="entry name" value="DUF5682"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18934">
        <property type="entry name" value="DUF5682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="782" mass="87769" checksum="D300B82FA59524C0" modified="2018-12-05" version="1">MAEPIQRLPGNERLTGDSGEVRVFGIRHLSPSGAYHLTEFLDAVRPSAILVEGPSDASGLISQIVSKGVVPPIALLAYTSQLPVRTLLYPFADYSPEYQAFRWADRHGAACEFIDLPSGNALALHGLTSEEDSESRAEDRQQYAFRQRELYRRIAELSEEPDYEAYWERQFEHNSGDQAYRETISVFSVRMRELTEQDELAFNPQGAAYNEIREAYMRRRIQETLEAGHAPGDVVVVTGAHHASVLTGTNHVMTDRELAALSFTDTRLTLMPYTYYKLSSHSGYGAGNQAPAYFQLFWECLREGRLPELPNRYLSNLAARLRERGTYRSTASVIEAVRMAEALASLRSGSQPTWQDLRDAAVVCLGGGELSVIAEALARVDIGTVIGRLPEGVSQTPIQDDLARELRRLKLEKYKSPVAQSLELDLRENRRVQSESAAYLDLNRSILLHRLEILDIRFARKLPVRQDAASWAEHWTLQWSPETEIQAVESTLKGETLEVAAAYVIHERLLSISHIGEASRLIRAACLCDLPKAMNDAKRLLQTLAVDAGSFEHVAEAAFELSTIIRFSSIRKHETESLVPLLRQLFLRGALSVNEAANCNDDAAAPVLSAVRMLHALAQEHDGEVDGDVWLRELNRLATRDDRNPKLSGFSFAILLEQDAWAGEEVAREVSRRLSPGIPADLGAGWFEGLSMRNRYALLSRPLLWEHLDAYIQSLEDEQFRRSLVYLRRAFSAFEPRDKAAVADLLGGLWGAEDSSLHLQRPLSEEEKESLDELNDFDFEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPF6</accession>
    <name>A0A398CPF6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoside triphosphate pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_23665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01371">
        <property type="protein sequence ID" value="RIE01371"/>
        <property type="gene ID" value="D3H35_23665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11723">
        <property type="entry name" value="YabN_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024180">
        <property type="entry name" value="Tetrapyrrole_Mease/MazG_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035013">
        <property type="entry name" value="YabN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002845">
        <property type="entry name" value="Ttrprl_mtas_MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00444">
        <property type="entry name" value="mazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TP_methylase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="MazG" evidence="3">
        <location>
            <begin position="259"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="MazG" evidence="3">
        <location>
            <begin position="404"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="493" mass="55803" checksum="781773D2D497E256" modified="2018-12-05" version="1">MHGTITIVGLGSGGENQLTLGILKKLEQATHRYVRTVDHPAVADLSARGIEFVSFDSLYESYGRFEEVYEAIAKTLLSAAADHPGESIVYAVPGHPMVAERAVQLLRERAVQEGIELQLLGGESFLDQAFVRLGFDPIEGFQLLDASELTREHLRPRLHTIIGQVYDAFTASDVKLALMSVYPDEYPVTVGQALGVPGQERILTVPLHELDRLDVYGNLTLVYIPADSSESLRRRSFERLHEIVSILRGPGGCPWDQEQTHQSIRKNFIEETYEAIEAIDNDDPDNMKEEFGDVILQVLLHSQMEEENGAFDVYDVLAELNDKLIFRHPHVFGGEDARNAEEALKNWEQMKAEEKRRKGVEERQSVLDGIPKDLPALPRAYKLQKKASRVGFDWPDLSGVFDKIEEELAELRQAASDESPERQKDELGDLLFAVVNAARFIKADPEEALAGTNRKFRSRFEYIEQQLRIRGRTFDETGLVEMEEWWQEAKLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPG1</accession>
    <name>A0A398CPG1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aspartate/tyrosine/aromatic aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04050">
        <property type="protein sequence ID" value="RIE04050"/>
        <property type="gene ID" value="D3H35_08855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="206" mass="22750" checksum="2351FE804D2703E1" modified="2018-12-05" version="1">MKPVAHVSNGIQFTGLSKEMRQTGLSSVMLYDLPYTDLSAYAGVVLTNYIDEEYLYEHRSIIHHFLQSGGVVCSFAEPYLPWLPGGVLWQRSPIPLKDREIIVAGDGHPIFQDIDPYDLNYKEGVRGFFSRGYFEMPDGAEPIIVDQSGSVIMYSQRLATGGTVLAGAGGDPAMFSSPGNTSRAAVPQLVNWIRAERARNEGRHPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPP2</accession>
    <name>A0A398CPP2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_11165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03259">
        <property type="protein sequence ID" value="RIE03259"/>
        <property type="gene ID" value="D3H35_11165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="260"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="517" mass="57099" checksum="B15723ACEB14F9B7" modified="2018-12-05" version="1">MREGYAIEMRDICKQFGPVIANDHVDFAARAGEIHALMGENGAGKSTMMCMLSGVYRPNSGEIRIDNVPVKIRSPKDAMKLGIGMVFQNFRLVPTLTAAENIVLGEKSSFLRGPKWMKNKQAEIKGIAEKFGLTFPVDVPVWQLSVGEQQRVEIVKTLYRGAGIIILDEPTSVLTPGEADQLFDTLRQMKNEGKTVILTTHKLKEVMATADRISVMRKGRMIHTIDRSETNERELARLMVGKEVAPERKASARTRGRPLLKVEALEVHADHGRKALDDLELQVHEGEIVGIAGVAGNGQKELAEVLNGLRSWKKGSIVFNGQEIKTASVRHMIEAGVAHVPENRMKSGLAGGLGAVDNLLFKSYRTDKRSRFGFLRTSGNRDWSKSLVEKFDVKTPDIDTPVQQMSGGNQQKLLFAREIDHDPLLMVAVHPTQGLDVGATEGVHRLLTELRDAGRAVLLLSEDLDEVLQLSDRVLVMYNGRIVGEMSGDEADRETIGMYMAGMYGHEDEKLAEEVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ49</accession>
    <name>A0A398CQ49_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_19930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02888">
        <property type="protein sequence ID" value="RIE02888"/>
        <property type="gene ID" value="D3H35_19930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017338827" evidence="2">
        <location>
            <begin position="27"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="222" mass="24454" checksum="0EED5132AB2F8214" modified="2018-12-05" version="1">MKYFVVLWIVFALALSGCSKTKQSEANTAAVQSTEPASESNKSEPAEPSKSPDENKKSGQSLKIDKGLSRTEVTLPASFFDENSNEEEVALKAKERGISEVKKNADGSYTYTMSEDAYNKIVKETKESTLEYINGLKGSSDFPSIKDIEYDDSLTEFTLIVDKTAFEKGFEGMVAIGISASGMMYQAFNGVKPDKLKVTVHAKDVETKKVFKTTVYPDAFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ69</accession>
    <name>A0A398CQ69_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_22165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01124">
        <property type="protein sequence ID" value="RIE01124"/>
        <property type="gene ID" value="D3H35_22165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="447" mass="50336" checksum="5C7C27110E4EADFF" modified="2018-12-05" version="1">MKMDTAYAVQQAIDYMEERIGERLEPERIAEAAYMSLPNLYRAFYALTGHPLMEYIRKRRVSQAAIQLRHFGDSVMDTALDCGFESYRTFAAVFKKTTGMTPGAYRKAQTYYSFERVNLAERIDYSEDRELSSRYPDVKVVRVGPVDVVSYRHVSSAREGLAEEAFAIFYKMLWEAGVNMNKIRLFGSDVPDSGSQPNTHEYVMMAPVRDAFTFAHPKASVIRLPGGLYALSKAPPGPAASITAAWNRVLAEWLPRSAFKLGDHPFMEEFQHLRGKVARLKLFLPVMRKKEHEAIGIAELSPVRVLAFRSEGKDAEAKVDERMSAWLTGRAGLGDSGTSIYMSCSYGISEEADSWYELALSVVDDMDLSVEDRGRISWLAGGLYAHMTTGAYGAMTGVLDLLHAWVCRNGEYRLDDQRQWFAKYVAGDDGDLDRSTMVVCYVPVLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQB9</accession>
    <name>A0A398CQB9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_04310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04713">
        <property type="protein sequence ID" value="RIE04713"/>
        <property type="gene ID" value="D3H35_04310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="317" mass="34958" checksum="FB4859390C9E4818" modified="2018-12-05" version="1">MTVVLSVEGLKKKIGRKTIIRNVSFDVRAGEIFGFLGPNGSGKTTTIRMLVDLIKPTEGRILVCGEDVNRHPERALKHVGCIVENPEMYGYMTGWENLEHFAGMQAGITPERIGEVVGIVGMDNRIHDKVKTYSLGMRQRLGIAQALLNRPKLLILDEPTNGLDPKGIKELREFIRMLAESGMSLFISSHLLSEIQLMCDRVAIIAHGEVLAVGEVDELVSQAGTYTVWQLDKPDEGRRLFGAASSEPILVPDSEHRIDEALLSSIRDPIVTTMDEESIPSWVETFVSAGIGVLSVQRVAPTLEELFLTLTEGEDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQD3</accession>
    <name>A0A398CQD3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_04420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04733">
        <property type="protein sequence ID" value="RIE04733"/>
        <property type="gene ID" value="D3H35_04420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="237"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="313" mass="35953" checksum="183230C74AB27B3E" modified="2018-12-05" version="1">MSLSQVIIPLFTHLLPVLFFVYMGVDVLLRNPGKVEHRLVSAIILCCMLLFMEEYVRNLLPIEYSPTLAAAWFSTVGIMIPGLGFHLFIKLARLKEKMPRIVYPYFFYLPAIIILINLLVDDSIISANEFYQEGLWKVPVYNQSYYIAMISSNVINFLYMIPLAKGRAKAGTRELKAIYNQLILGVTLSTLCNMVFGLIDYGSSLPPYPYLYGCVVWCFILRHTMKTYDFLNFMDKRYEKLFNLNPAAIMLVDLQGNIKEANPSAKQFFDSIGLEQANFYATLHDDFKNRIQAREAIANCEMTIWNEKKGGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR02</accession>
    <name>A0A398CR02_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">phoU</name>
        <name evidence="3" type="ORF">D3H35_20045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03218">
        <property type="protein sequence ID" value="RIE03218"/>
        <property type="gene ID" value="D3H35_20045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="18"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="121"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="219" mass="24423" checksum="4403DE8F802DC7D4" modified="2018-12-05" version="1">MVKRREFDLGLEELQSLLREMGTRVESALTESMNALKTLDIAKAKAIIGSDLELNNLEVKITELGAKLIATQQPVAKDLRSILAAFKISGDLERMGDLSVDVAKVVLRLDGQTLIKPLIDLPRMAEITVQMTKDAVNSYLEENVDLAYKMAKDDDTVDALYSQIIRELFTMMVEDPKTISQSMLLSFVGRYLERFADHATNIGESAVYLVTGKRPDLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR14</accession>
    <name>A0A398CR14_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02267">
        <property type="protein sequence ID" value="RIE02267"/>
        <property type="gene ID" value="D3H35_16175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="81" mass="8948" checksum="A59FA5DB7B352044" modified="2018-12-05" version="1">MDLVTSFFILQNSILSKKNAEKHNSLQPQETTEKAAITEKSLQQLLSRFGAASQTAIFLNREANFPGMVQTYSYPLLAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR31</accession>
    <name>A0A398CR31_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Urea ABC transporter permease subunit UrtB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">urtB</name>
        <name evidence="7" type="ORF">D3H35_23740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01384">
        <property type="protein sequence ID" value="RIE01384"/>
        <property type="gene ID" value="D3H35_23740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017779">
        <property type="entry name" value="ABC_UrtB_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03409">
        <property type="entry name" value="urea_trans_UrtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="301" mass="32810" checksum="D3598AA23B42977B" modified="2018-12-05" version="1">MEIWISQLFNGISVSSILLLIALGLAITFGLMRVINMAHGEFIMIGSYSAYVTQQFFQKSLPDGMFGVYFPVAILFSFVVAFAFGYLLEGTLIRFLYGRPLDSLLATWGVGLILQQLARTIFGAPNVAVSSPKWLDGGWTIMEDVVLPYKRLFIIALVALCLFAMYLYIYRSNAGRRMRAVMQNREMAACLGISTRRVDAVTFAIGSGIAGIAGCALTLIGPIGPNIGTYYIIDAFMVVVLGGVGKLVGTVAGALGIGMFNSLFEWWTDASLGKVLVFLGIVAFLQWKPMGLFAVRTRSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR88</accession>
    <name>A0A398CR88_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FMN-dependent monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_02585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05042">
        <property type="protein sequence ID" value="RIE05042"/>
        <property type="gene ID" value="D3H35_02585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="410"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="206"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="440" mass="48983" checksum="58D4C241F98CBE0B" modified="2018-12-05" version="1">MWAHPDDEGHRYKELSYWTELAQLLESGGFDAIFLPDVLGQYDVYKGSRNTSLEQAIQSPINDPTYLLPAMAAVTKHLGFAVTSSTTYEHPYALARKLSTLDHLTQGRVGWNIVTSFLTSAARNFGLEAQLGAEERYDRGEEYLEVCYKLWEESWDDGAVVRNTEARIYTDPAKVRDIGHEGKHFRVPGIHLSEPSPQRTPVLFQAGASSSGRDFAAKHAECIFLNTPTLEATRAIVEDIRGRAAKLGRKPEHILFFPKLTVITAPTDEEAEAKYRDYLNYSSTEGLLALLGGWSGIDFSQFGPEKLLKFAQNSGNRSIVEYINERPEKKWTVEELANLYAFGTSSLHVGSPAKIADAMERFVEETGVDGFNISYLTRPGTIRDFVELVVPELRRRGRVQAEYAPGTLREKLFGQGPGLPDSHPGGNRRQAAAIPEGARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR95</accession>
    <name>A0A398CR95_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_02845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05085">
        <property type="protein sequence ID" value="RIE05085"/>
        <property type="gene ID" value="D3H35_02845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="69"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="256" mass="27953" checksum="84A53CEC077BAAD4" modified="2018-12-05" version="1">MKRQYSVPALAKGMSIMEMLASSRDTLGITDIYDRTGLPKSSIFTILSELEHLGYVAKTEDGKYQLTLKLYNVGMERLSKLDIRQAARPEMEWMAENLKFTVHLAILEDDKALYIDKVNGPGFVQFSTQIGQTQLLHNSGVGKALAAYMADDQLLQAIAKHGMPKTAAHTMTSLEEFKPFLVGVRETGYAIEDEEGEAGIRCIAAPIFNHTGKVAGALGITALSSELPSRAFGECGELLRAKALAVSNKLGYIPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRC6</accession>
    <name>A0A398CRC6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribose 5-phosphate isomerase B</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpiB</name>
        <name evidence="4" type="ORF">D3H35_14520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01981">
        <property type="protein sequence ID" value="RIE01981"/>
        <property type="gene ID" value="D3H35_14520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004785">
        <property type="entry name" value="RpiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01120">
        <property type="entry name" value="rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="8"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="152" mass="16490" checksum="17635DE2B141BBDF" modified="2018-12-05" version="1">MKIAIGADHAGYRLKDVVIPFLQELGYEIVDVGSHCADSVDYPDYAVPVCDMVVKGEVERGVLICGTGIGMSIAANKTPGIRCALVHDLFSAKATREHNDTNVLAMGERVIGPGVAQEILKVWLETPFSQGERHIGRINKVKALEAKQELHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRU6</accession>
    <name>A0A398CRU6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000011">
        <property type="protein sequence ID" value="RIE05315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05315">
        <property type="protein sequence ID" value="RIE05315"/>
        <property type="gene ID" value="D3H35_01175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="61" mass="6832" checksum="4C3A8D25692DF2C2" modified="2018-12-05" version="1">MSIRLRLTLWYSGLLAAVLIGFGLLIYSVVYNSTMSDIRGELAKLSANMRVQAKILMAVWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRW2</accession>
    <name>A0A398CRW2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_01160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000011">
        <property type="protein sequence ID" value="RIE05312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05312">
        <property type="protein sequence ID" value="RIE05312"/>
        <property type="gene ID" value="D3H35_01160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="158" mass="17918" checksum="A1E01D160FFE9F31" modified="2018-12-05" version="1">MDRRPFEALDGVWVKGNKDYLLQLLFILIENGFKYTPSGKVRLYASRSGNHVGLTVSDTGIGLAAEDLPHIFDRFYRADQSRGRRPVRVSPIHCEVDRRHAQGKAGSKIANGRRHLLYSMASDFEPRTVDFAQSGEYGIMEPSERPDFSNSESREDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS49</accession>
    <name>A0A398CS49_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type III-B CRISPR-associated protein Cas10/Cmr2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cas10</name>
        <name evidence="2" type="ORF">D3H35_00885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05373">
        <property type="protein sequence ID" value="RIE05373"/>
        <property type="gene ID" value="D3H35_00885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038242">
        <property type="entry name" value="Cmr2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024615">
        <property type="entry name" value="CRISPR-assoc_Cmr2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013407">
        <property type="entry name" value="CRISPR-assoc_prot_Cmr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12469">
        <property type="entry name" value="DUF3692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02577">
        <property type="entry name" value="cas_TM1794_Cmr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="360"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="643" mass="73512" checksum="64C703F50D27CF11" modified="2018-12-05" version="1">MFEERGSEAVEKDAAVQTLIVISIGPVQDFIAQARKTRDLWFGSHLLSELSRAAAEQFQKEGELIMPVLPAKELSDERTEKLPIANKIIGVVRREKPEDFVNEVHDAVQEKWKTYTQQAQKHLEAEGAINPEMWKRQVRDFVEFHAAWSGLSDGRSYRETLERTNQLLAARKTLRDFRQNEPARMYGDKKSSLNPGRESVLLESRYSNYARFGIRKGETLDAVSLVKRLSTWITADKQSSENKASFASVCDLAFSSFRQRLKDEPTLEAKAAELYKGLITECEPHLTMRSRVVHASKADEFDSRLFYPHQIKDFVDEHAYREVSGKKAATLNEVEKKELTSRLRRRIRSGLRHPLSAPSPYYAFLLCDGDRIGDRLKKVLSPELHRQWTERLSRFAVESRIIVQQNDGEFIYGGGDDCMALLPLHTCLQAVDELRLRFAELMRGEQNVAEEEPVTLSAGLVIAHMMEPLGQVRHMAQEAERQAKLCRNRLFVHVQKRGGGEQLKVGMSWKENPVQILNQWRQLYRDNAIPAQLAYDLRQLHRTYLKMAGFPSLASADGDRDRPKAELQNKELLVLEVARLLRKKQLDNCYMQNGSLETISQRMASFIRAGEESALARLEMLAEQLTLAMTLNKMEAGQDVDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS60</accession>
    <name>A0A398CS60_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GGDEF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02637">
        <property type="protein sequence ID" value="RIE02637"/>
        <property type="gene ID" value="D3H35_18320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="69"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="194" mass="22015" checksum="9F3B00F4247992CD" modified="2018-12-05" version="1">MACWQRRSRLRDRRRGARLVSRTELRPFEGVGRPGFFDRRLYPALSCPMLSQAGHESGALEPQIRRRPDRSGRVQRVNDKLGHEAGDGLLCKVARTLREQSTLGEIVGRIGGDEFLVLCPYGDSAALEKYGERLNKKLIELSAGWNHHPLSMSIGYAVFPEEGRTLEQLMRAADCKMYADKQRADPLVNRRMHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT25</accession>
    <name>A0A398CT25_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_07435</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04409">
        <property type="protein sequence ID" value="RIE04409"/>
        <property type="gene ID" value="D3H35_07435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="790"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1334" mass="147139" checksum="E190770094EA18FA" modified="2018-12-05" version="1">MMEVGNPILYELDDDREEIAEARDYWLAHLSDDPKPASIQPDRAEGGVDRSFGSLSFAWPEPLSAKLLELARGQDTLLYVVLLAGLATVVRKYGGESDMTVASPEYAGFGSGDGDARLATNRYLPIRCRLDGDMTVKELLTAVNRTVTSAYRYQYYPVRKALEKQGLEDRSYGKMACELTNIHDSRALESLRNSGDNEISVSFTRAEGRLEGRIAYDVSLFTERSVHTLLDVCEYVLEQAAADPGASLRSLELVRAPERERMLAEFSGNKWDLPANVSMSRLFEEQAAASPSRTAVVSGTERLTYGELNEKANTLADRLRRRGVGNGRVVGIMLEKSVLMVTSILAVLKAGGAYLPLDPGYPEPRLRHMLEDSGTEVLLTSALFAGRLPFAGNTVIVDAIPPEEEAEGDEAFSQTTGQAALADDLAYMIYTSGSTGKPKGVMVGHRGMVNLQSFFKRELNVRENDRILQFASASFDASVWELFMALFTGAELHLPAREVLESYDRFTDYLNGNGITIATLPPTFAAHLDPSGVQTLRLLITAGSATSPELVRRWKGRVEYVNAYGPTESTICATIWKADEAFGEDEPDGSAASSPRSVPIGKPILNADAYIVGCDGQLQPIGVMGELFIGGVGVALGYWGRDSLTAEKFVPNPYKPGETMYRSGDYARWLPDGNIDYRGRIDHQVKIRGFRIEIGEIETELLSHPDISEAAAAAKSLAEGDVGLCAYYVASSPIRPQEIKDWLALRLPGYMIPQYMIPLDKLPLTVNGKVDLAALPAPGSSGSGGGTLDENASETEKKLARLWSEVLGISSIGADAHFFEAGGHSLRAALLISEIHRTFHAQLSLRDVMEAPTLREMAKRIEENGGKGSFEAIVPAAQKPYYPLSPAQKRLYVLSRFDPESVAYNLPAALLLEGELDTDRLKRAFQALTSRHETLRTSFGLEDGAPVQFVHSSADVSFEIASEPLGEIGVDATEKAVKQFVRPFDPGVAPLLRVRVIRYSDTRHTLLLDMHHLISDGISTSVFIRDLLQLYAGERLDPLPLQYKDFACWQSGRLEAGGMEEQERHWLSQFSVPVPSLGIRTDYPRPSEPLFDDGDAVVRTIPAEKTNGLRELAASADSTLYMVLLAAYSTLLSRYSGDEDIVVGTPVAGRRHADLQGLIGMFINMLPMRTRPKAGLSFADYLNDVKDTALQALENQDYPFDELVRKLNAQRDFNRNPLFDASFALQNMDMPRIEAEGLAIEPINIRFHPAKFDLTLWAEEGEDGLRLTLEYRPALFKQETIAKMVDDLTTILDRIVEEPQIELGEIELLGDEEQRAMASRLARLEQDLEMEFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTJ7</accession>
    <name>A0A398CTJ7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Riboflavin biosynthesis protein RibBA</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="13">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
                <shortName evidence="13">DHBP synthase</shortName>
                <ecNumber evidence="13">4.1.99.12</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="13">GTP cyclohydrolase-2</fullName>
                <ecNumber evidence="13">3.5.4.25</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="13">GTP cyclohydrolase II</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">ribBA</name>
        <name evidence="15" type="ORF">D3H35_03645</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">In the N-terminal section; belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="13"/>
    <dbReference type="EC" id="3.5.4.25" evidence="13"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04599">
        <property type="protein sequence ID" value="RIE04599"/>
        <property type="gene ID" value="D3H35_03645"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00180">
        <property type="entry name" value="RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01283">
        <property type="entry name" value="RibBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016299">
        <property type="entry name" value="Riboflavin_synth_RibBA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="14">
        <location>
            <begin position="210"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="DHBP synthase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="13">
        <location>
            <begin position="30"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="13">
        <location>
            <begin position="142"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="GTP cyclohydrolase II" evidence="13">
        <location>
            <begin position="204"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for GTP cyclohydrolase activity" evidence="13">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GTP cyclohydrolase activity" evidence="13">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="254"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="297"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="13">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="13">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE04599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="419" mass="46315" checksum="9D0BD9214CC0049F" modified="2018-12-05" version="1">MKTITFDSIEDAIKDLMLGKAVVVVDDEDRENEGDLIALAEKATPEVINFMITEARGLVCVPIMPERAEELDLPPMVGHNTDYHGTAFTISVDHVSTTTGISAPERAATVRALIDPSVKAVDFRRPGHIFPLIAKNGGVLRRAGHTEAAVDLARMCGSAPGAVICEVIKEDGTMARLPDLAEFSRKHDLKLITIEALIRYRNETENLVHREVEVRMPTDYGTFSAIAYTNDVDSKEHIAMVKGTIDGSKPVLVRVHSECMTGDVFHSHRCDCGPQLEAALRQIDEAGAGVLLYMRQEGRGIGLINKLRAYQLQEQGLDTVEANKKLGFPADLRDYGIGAQILKDIGVRDIRLLTNNPRKIKGLEGYGLNVVERVPLQMEENEDNTGYLHTKKKKLGHLLSFADDGLDEYEQGEYPEYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUC4</accession>
    <name>A0A398CUC4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03447">
        <property type="protein sequence ID" value="RIE03447"/>
        <property type="gene ID" value="D3H35_12370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="133" mass="15108" checksum="EC794CD02BAEA411" modified="2018-12-05" version="1">MLSIGEVARQSGASASTLRYYEQIGLIPPPQRISGKRAYTEEIVSRLEIIKLAQSAGFQIVEIKQLLDGFDSNVPPSERWRVMARQKQQELEEQINQMKRMQSVLAKSIGCDCLSWEQCFSDPSPMTIKMKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV41</accession>
    <name>A0A398CV41_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LysR_substrate domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03131">
        <property type="protein sequence ID" value="RIE03131"/>
        <property type="gene ID" value="D3H35_14390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysR_substrate" evidence="1">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="75" mass="7961" checksum="0103D4594CA38FF5" modified="2018-12-05" version="1">MPNSANIPRLPHACRSRLSEDAMYIAVGAGHPLANTASVAPERLSEQTWLVREIGSGTRAATEGMFAEFGIHPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVH4</accession>
    <name>A0A398CVH4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Efflux RND transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000012">
        <property type="protein sequence ID" value="RIE05309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05309">
        <property type="protein sequence ID" value="RIE05309"/>
        <property type="gene ID" value="D3H35_01290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="411" mass="44186" checksum="3584407F06C62542" modified="2018-12-05" version="1">MEWNLRFKWLPILIAFLLLLGSVGTYFSLPKGAIDNSSASSLSITLDYKPDTPVDEVRENGLKLEKFLMEQEGQDYVDMQMGNSADGATYGNVNSPTLVSYTVQMKDGADADKIIDAVKGQRANYPGADLNAGPGSFFGGGSSTQVFVDVTGDNLDQLTKSADEVIAKIKPIKDVLKVESNQEEKKTVYTLKVNASQAKAGDIASQLQGMLNSVPIGTMKANGQPVSVILEPVLKPQSEADLENLTVMTDAGPKPASSVAEWVKEELPTKFFHKDGKSYVRVAATVEPSQLSIVGADIKKAMNDVKTPDGVKLNVGGASADQSEDFMSLFMMMLVSIGIVYLIMVITFKTLKAPLAILSSLLFVPIGAVLGLLIGNVKPDFTAIFGVVMLVGIVVTNAIVLIDRLDRTKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVV9</accession>
    <name>A0A398CVV9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal protein S12 methylthiotransferase RimO</fullName>
            <shortName evidence="8">S12 MTTase</shortName>
            <shortName evidence="8">S12 methylthiotransferase</shortName>
            <ecNumber evidence="8">2.8.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ribosome maturation factor RimO</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">rimO</name>
        <name evidence="12" type="ORF">D3H35_11745</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37087"/>
            <dbReference type="Rhea" id="RHEA-COMP:10460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10461"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:73599"/>
            <dbReference type="EC" id="2.8.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="8">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the methylthiotransferase family. RimO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.4" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03351">
        <property type="protein sequence ID" value="RIE03351"/>
        <property type="gene ID" value="D3H35_11745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103039">
        <property type="term" value="F:protein methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018339">
        <property type="term" value="P:peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01865">
        <property type="entry name" value="MTTase_RimO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041582">
        <property type="entry name" value="RimO_TRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18693">
        <property type="entry name" value="TRAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00274">
        <property type="entry name" value="ribosomal_protein_S12_methylth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01125">
        <property type="entry name" value="TIGR01125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 8 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="10">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="142"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="9">
        <location>
            <begin position="375"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE03351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="442" mass="49576" checksum="B34DC461F2035A6E" modified="2018-12-05" version="1">MPEKVSVVTLGCEKNLVDSEIMSGLIHQRGFSLVQKPEEATVVIVNTCGFIDAAKEESVNTILSLAELKETSRLKALIVSGCLTQRYKQELMTEMPEIDGIVGTGDFHRINDIIDEALGGRKPVYVGNPVFTYEENMPRLLSTPSHTAYVKIAEGCDNACTFCSIPIMRGKFRSRSVESIVSEVKSLAAQGVKEVSLIAQDSTNYGTDLYDGFKLPELLNKVSEVEGIAWVRLHYAYPGFFTDELIETIATNPKICKYIDMPLQHSEDSILKRMRRPGRQRDIRELIAKIRARIPDVAIRTSMIVGFPGETEEDFNSLCEFVRELKFDRLGVFAYSQEEDTPANRLPKQLSDEVKQTRAIALMEIQREVAKENAAKYVGRTIEVLVERYDGRSDVYVGRSQFDAPEVDGEVYITGCSTEIGEIRRVRITHAYEYDLSGEGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW54</accession>
    <name>A0A398CW54_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_12330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03441">
        <property type="protein sequence ID" value="RIE03441"/>
        <property type="gene ID" value="D3H35_12330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="307" mass="33502" checksum="9F0E979314E41286" modified="2018-12-05" version="1">MDPVIRLDKIRKTYGAKLAVDDLTLEIGKGEIFGIVGPNGAGKTTLIEIIEGLRQADGGTAAVLGMDIGKEADRIKQKIGVLLQSTSIPGKARVGELLRLFSSFYDKSADVQAVARSFGLDDKLDAMYKSLSGGWKQRVALALSLINDPEIVFLDEPSMGLDPNARHEMWQTILKLRKEGRTIVVTTHYMEEAEALCDRVAIISGGRLIALDAPNKLITMLGGTKRLSFKNPGKSGKAAFESLANVVGVEWEAEIVRLQTTDMDLTLKHLFHLADKEDWLVSGLRLEEATMNEVFTALTQRHGGTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW93</accession>
    <name>A0A398CW93_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03481">
        <property type="protein sequence ID" value="RIE03481"/>
        <property type="gene ID" value="D3H35_12595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="154" mass="17165" checksum="D6660B766949DA52" modified="2018-12-05" version="1">MATDSKGAPSSNEENDEAFLHNCLYFTTNRLSRAITRMADEAFATTGLTPAYGYLIRLVIGKPGSTQKELSEKLYIAPSTLTRFIDKLENKGLVKRKVQGKTVLVYPTERGMELEQAVRQASRRLHDAYEAILGVEASDKLTYALESSSEKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWH3</accession>
    <name>A0A398CWH3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">dnaK</name>
        <name evidence="12" type="ORF">D3H35_06030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="9">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04177">
        <property type="protein sequence ID" value="RIE04177"/>
        <property type="gene ID" value="D3H35_06030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="9">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE04177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="614" mass="65482" checksum="A6ED7870F78B276E" modified="2018-12-05" version="1">MSKVIGIDLGTTNSCVAVMEGGEAVVIPNAEGNRTTPSVVGFKKDGERVVGETAKRQAITNPDRTVISIKRHMGTNHKVSIDGKDYSPQEISAIILQKLKADAEAYLGQPVTQAVITVPAYFNDSQRQATKDAGAIAGLEVLRIVNEPTAGALAYGLEKSEDHTILVFDLGGGTFDVSILELGDGFFEVKATSGDNNLGGDDFDQVVMEWLSGEFKKEHGIDLLKDKAAVQRLKDAAEKAKKELSGTVSTTISLPFITVVDGIPQHLELNLTRAKFDDLTASLVERTMGPTRQALSDAGMTASDIDKVVLVGGSTRIPAVQEAIKKLIGKESHKGVNPDEVVALGAAVQAGVLTGDVKDVVLLDVTPLSLGIETAGGVLTKMIDRNTTIPTSKSQVFSTYADNQTSVEIHVLQGERAMARDNKTLGRFILSDIPPAPRGIPQIEVTFDLDANGIVNVSALDKGTGKSQKITITSSSGLSKEEIERMQKEAELHAEEDNKRRELIEAKNGADQLIYTVEKTIKDLGDKVDAGEIAKAEEAKENVKKALEGDNLDEIKAATEALTEIVQQLSVKLYEQAAQAEQAGQDGAADAGAASAKKDNVVDADYEVVDEDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWY5</accession>
    <name>A0A398CWY5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RidA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05088">
        <property type="protein sequence ID" value="RIE05088"/>
        <property type="gene ID" value="D3H35_02860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="124" mass="13307" checksum="3B3255B7F85AE54A" modified="2018-12-05" version="1">MRQAVRTKDASIGSGPYSQGIKAGNMLFVSGQGPLDANGAILSGDIEAEARLTMDNVREIVEAGGFTMNDVVKVGVYLASLADFDRFNAVYKTYFNEPYPARTCVEAGLDGIKVEIDAIVCKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX39</accession>
    <name>A0A398CX39_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Stage V sporulation protein SpoVM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04397">
        <property type="protein sequence ID" value="RIE04397"/>
        <property type="gene ID" value="D3H35_07375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012609">
        <property type="entry name" value="Spore_V_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08183">
        <property type="entry name" value="SpoV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="26" mass="3034" checksum="16E4FA1C0BC810D3" modified="2018-12-05" version="1">MKFYTIKLPKFLGGFVKAILNTFNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX47</accession>
    <name>A0A398CX47_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CPBP family intramembrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04407">
        <property type="protein sequence ID" value="RIE04407"/>
        <property type="gene ID" value="D3H35_07425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="556" mass="62067" checksum="DDAFB4B87C003B16" modified="2018-12-05" version="1">MKNYIRMIVNLVLYLGVTFLVFWGVGILKEQNETFKRLLDDNPPVLLIICACIIYLILTLLFQVRHKLTKSEPKRLLDAVGFRKLNDNEYVGSFLVGAGCALFFFGLMTLSVLPEKTLYELNNYVDVFSKSDAFVFAILGAGVIGVLFEEVYFRGLVFGELRRVLPLPVAFLAHAAVYAYFQPNLTISITGFFLALFYSFMYVKTKSVWSTVTAAATLNITIVAAKEYGLIEALGKGNDFMPVAVLVVGAIFVLLGLFRISRFAGIESGTGGKVEAYLKAIAAAGAYIAIYYAVLTSVIYIWTQVLTSYEPIRPWLNESSNNLWALVINDIIAVALYFFILRRYRSVNLFELCGFSRISRSTVVQIAILSISMGLWVTSIAKIPYVEETFPQFDTLFNSLVGGPLLPFIVFLLFHSVYKEILFRGLIFNAFKTAMPLAVVFLLDALVYGQLFFQWDPALTIYGGMGTVIFGLLYLWYRSLWAPIVAQLGLFATYYAARHSIAAFEIEFNGAFYAVMVVSSASVLFFMIRLWKKRTSAVPAPQPSAIPAKRGARAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXE5</accession>
    <name>A0A398CXE5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RsgI N-terminal anti-sigma domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_10215</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03664">
        <property type="protein sequence ID" value="RIE03664"/>
        <property type="gene ID" value="D3H35_10215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024449">
        <property type="entry name" value="Anti-sigma_RsgI_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12791">
        <property type="entry name" value="RsgI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51849">
        <property type="entry name" value="RSGI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="RsgI N-terminal anti-sigma" evidence="9">
        <location>
            <begin position="2"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="263"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="274"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="365"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="421"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="455" mass="50492" checksum="2C91C4BA1BD6AE93" modified="2018-12-05" version="1">MSQGIVMSIDRSTAVVMTSDGRFVRLKKTDRHELGLEVAWDSSELASSGSYGLAVRKAIIGLPRRWVLTAASVAAMFVLLFGIWSLRPPEVVAYVSMDINPSVELGLDSKERVRVLRAINRDARPIVEGIAYKGHSIEDVARQLADKLAEARVLSERDSEVVIASVPVKQLDSEWERHVTGAIEKALSEAASPAAGGSSSALRVTKISLPEEVREEAKTYGVSSGKMAFWLKAESEGHEVSLDTLKKNSLKKIASSWGGVDKVMTGDVEAPSEKDNIATGKNDAKENSGNQAKDDKKEDDDWKKLLDNLKTKKDQKQQTKQTNQTKQSNRPKQEKNKEDSEKNKPQKDDKSDSNKSGGRTQQENTKQDSKQESKTDKEKGQKGRETDKKRDGEQEKERDSKKISSKKQDSKPTVDQPEMSGSGHKNEDARNKNRDRDRNTRHNDDDKGGKSSHQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY11</accession>
    <name>A0A398CY11_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000005">
        <property type="protein sequence ID" value="RIE05428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05428">
        <property type="protein sequence ID" value="RIE05428"/>
        <property type="gene ID" value="D3H35_00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039650">
        <property type="entry name" value="HdrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498">
        <property type="entry name" value="PTHR43498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="80" mass="8767" checksum="A98386501276A87D" modified="2018-12-05" version="1">MYAADYTSRHYHSDGIYQIPYRSLYSFNVNNLLFAGRNISATHIAFGSSRVMGTCASVGQAGRYRCCALCGEQGYPAGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY80</accession>
    <name>A0A398CY80_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SUF system NifU family Fe-S cluster assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03954">
        <property type="protein sequence ID" value="RIE03954"/>
        <property type="gene ID" value="D3H35_08315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="148" mass="16144" checksum="DC6041D6BD009B9E" modified="2018-12-05" version="1">MQLDDLYRRVIMDHYKNPRNRGTLEDGSVTVNLNNPTCGDRISLQLQVEDGIVRNAKFSGEGCSISLSSASMMTDAVKGKTAAEALALAEKFSSLMKGESVEFEEYEDIEALSGVNKFPARIKCATLAWNALRKGVEQGNGKHDGVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYB4</accession>
    <name>A0A398CYB4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GHMP kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_08530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03994">
        <property type="protein sequence ID" value="RIE03994"/>
        <property type="gene ID" value="D3H35_08530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001174">
        <property type="entry name" value="Galkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014606">
        <property type="entry name" value="Heptose_7-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036406">
        <property type="entry name" value="Hept_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00960">
        <property type="entry name" value="LMBPPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="5">
        <location>
            <begin position="87"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="6">
        <location>
            <begin position="227"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="340" mass="37823" checksum="E92BBA7BF714717E" modified="2018-12-05" version="1">MIISQTPLRVSFFGGGTDLKDYYENHGGAVTSVTIDKFIYIIVKRRCDDDIVLNYSEREQVKDIHDIKHPIIREALRLANVTKGVEITSIADIPSQGSGLGSSSSFTIGLLNALFAYQGMWKNASELAELACHIEIELLGEPIGKQDQYAAAFGGFKQYMFRRDGSVDVEAIGITQEDSRLLQMNTLMFYTGMTRKASAVLGDQKANTDAKLSQLHALKKLSDLGKEGLVNGDIRLIGDMLHQNWENKKLLSDKIHNDEINRMYDLGRQAGAYGGKLLGAGGGGFFLFVCPPDKQLDLRRALRDYKELPITFEQYGSRIVMNLNDRSGFLQYREPAALAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYE8</accession>
    <name>A0A398CYE8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonucleoside-diphosphate reductase subunit beta</fullName>
            <ecNumber evidence="4">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nrdF</name>
        <name evidence="8" type="ORF">D3H35_05110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 6">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="4 6">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04847">
        <property type="protein sequence ID" value="RIE04847"/>
        <property type="gene ID" value="D3H35_05110"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026494">
        <property type="entry name" value="RNR_NrdF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000355">
        <property type="entry name" value="NrdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04171">
        <property type="entry name" value="RNR_1b_NrdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="322" mass="37028" checksum="726938D8F78EB856" modified="2018-12-05" version="1">MAVMKAVNWNRPDDDFTITFWNQNIMQFWTDEEIPLSDDKMSWMTLSDTERDLYMKVLGGLTLLDTVQGGIGMPKILEHVDGLQRKAVLGFMGMMEQIHAKSYSSIFTTLATTEEIDGVFRWVEQNEYLQTKADTIAQYYRRIETKKDLYLAMAASVLLESYLFYSGFFYPLYLAGQGKMTSSGEIIDLILRDESIHGLYVGVLAQEVYAELSDDERQDAYETLCGLLQFLNQNEEGYTDSLYSDVGLADEVKKFVRYNANKAFMNLGLDPQYPEEEVNPIVFNGISTRTKQHDFFSKKGNGYIRTLNVEPLTDKDFVFDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZS8</accession>
    <name>A0A398CZS8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lasso peptide biosynthesis B2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05367">
        <property type="protein sequence ID" value="RIE05367"/>
        <property type="gene ID" value="D3H35_00855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032708">
        <property type="entry name" value="McjB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13471">
        <property type="entry name" value="Transglut_core3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglut_core3" evidence="1">
        <location>
            <begin position="33"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="151" mass="17387" checksum="71E50C3A7447EB64" modified="2018-12-05" version="1">MRRLRTFMAWPAEKKRLMLEALFFLAWARILKSLPFPRLAPSLGRPMTETPSVHDLSNERLIRRISEAVRVMSRHTFWESQCLVQALAAKKMLERRSMDSTLYLGTAKDRQGNLIAHAWLRSGPIYLTGAGERHLFTTVASFGTDKSNRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZX7</accession>
    <name>A0A398CZX7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein Hfq</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hfq</name>
        <name evidence="2" type="ORF">D3H35_04585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Hfq family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04761">
        <property type="protein sequence ID" value="RIE04761"/>
        <property type="gene ID" value="D3H35_04585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01716">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00436">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005001">
        <property type="entry name" value="Hfq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34772">
        <property type="entry name" value="PTHR34772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17209">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02383">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="80" mass="9208" checksum="97179A585F20070A" modified="2018-12-05" version="1">MNKSINIQDTFLNQLRKDSIPVTVYLTNGFQIRGVVRAFDNFTIVIDSDGRQQMVYKHAISTFMPQRNVSLMQQDHSSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D042</accession>
    <name>A0A398D042_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5668 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000001">
        <property type="protein sequence ID" value="RIE05487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05487">
        <property type="protein sequence ID" value="RIE05487"/>
        <property type="gene ID" value="D3H35_00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043726">
        <property type="entry name" value="DUF5668"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18917">
        <property type="entry name" value="DUF5668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5668" evidence="1">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="125" mass="13332" checksum="8396F448D7E750B1" modified="2018-12-05" version="1">MQSSFLHRFFWGIVVIAIGVVFLLNQTGAASFDIGELFSVYWPVIVIFSGCRDCCSNATAACAGIRSSLRSAFIFWAEIWTGSSGKSASYGPLSSYGSASACCFEAIGRSVPIAKPITERTDGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D057</accession>
    <name>A0A398D057_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_05525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04554">
        <property type="protein sequence ID" value="RIE04554"/>
        <property type="gene ID" value="D3H35_05525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017422397" evidence="2">
        <location>
            <begin position="26"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="557" mass="61673" checksum="1DF9CFACE2170483" modified="2018-12-05" version="1">MNGKQKKPWLLGALTLILAGMFAMAGCSSNNGNGNENGSASPIVTPSGSPPASPSSTPSAAPAEEPYSIKLLLPQDISKPYDPAKDAIKKAVEEKLGVTLVPEIVDVQQYKTKLNLKMSSNDIPDIVRIDFADDFQKYAPQGAFVDLTELINEKDTPNIWKEVPQQVFEQAKVNGKIYGIPYQGGPGSGYRWNLVMRSDYLKEVGESVPTTLDAYYNALKKIKEMKKDVIPLGGYTAKTGEVKFATNSFDNIFGAFGVTPGYFTQQDGKFSNYDIDPRMKEALKFLQKMYAENLIDKEFATIKEEQFRAKLFAGKLFSWMGWWSTAKDYDTQIESFELKKSGKLDKDGTLPDQSSEPYKYLSLTGSLTGADGKAVAPQGAPFGQVLAISAKTKDPKKLLAIIDKSLEIDNQMLTVWGVENVDYELTGGKLQQIPTAIDQATQTDKDGNFRGTQRYTWAPGLKGWPHYLESLPLRPSMALDTAINNPNQITDAANYLDSPTKIAKQVELNTMRDSYFTQIIMGASIDKFDEFVAKWKSQGGDQILQELEQSYQKKMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CB82</accession>
    <name>A0A398CB82_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_28760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00406">
        <property type="protein sequence ID" value="RIE00406"/>
        <property type="gene ID" value="D3H35_28760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="72"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="296" mass="32693" checksum="D03836693EC97C8B" modified="2018-12-05" version="1">MALENKSLKWLAYFVLGSFSLACIVPFVLLIVSSLSSEASIIQKGYTFFPEAFSLKAYDYLWLHHLELGRAYGITVLITVVGTVVSLAITSMLAYPLSRRDMPLRNFWTFLVFFTLLFNGGLVPTYLVYTQIFDIKNTIFGLLVPGLLMNGFNVLLVRTFFLTSIPPALIEAASIDGAGEIRIFYRIVLPLSLPIMATIGLFQAIGYWNDWFNGLIYLTDSRLFGIQTILTKMIMDIQFLTSNSNAAGSGAGQAVAEIPGTSVRMAIAAIGVLPILIAYPFFQKYFVKGITIGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CC14</accession>
    <name>A0A398CC14_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000058">
        <property type="protein sequence ID" value="RIE00320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00320">
        <property type="protein sequence ID" value="RIE00320"/>
        <property type="gene ID" value="D3H35_29180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="139" mass="16140" checksum="9C5B187290C7C90C" modified="2018-12-05" version="1">MIERLSNVDALPSLFARKFVSFWGGPDSSAFWSMEKLNMPKQTERVNKLERAVYAAMCFFGAIGLLALVRDRQYEWHRLFLILLFGYAAIHLFIEIQGRYRLDMIPILVLLQSYGVYAAYSRITLWLSPRADRDQGVPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCS1</accession>
    <name>A0A398CCS1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_28165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000054">
        <property type="protein sequence ID" value="RIE00500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00500">
        <property type="protein sequence ID" value="RIE00500"/>
        <property type="gene ID" value="D3H35_28165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="138" mass="15984" checksum="1240024F53989421" modified="2018-12-05" version="1">MRHVRRVQQSCYRFPFFSDGNLYLFPEGKYGEAFWYYKKPFEENNIKVPTTFDEFVDAAAKLKRRVIRDRGIRQGDVAAGSLPVVHPSSSDHTEFIDKLKTGTKSLPEKSHESGELAFHARQGRYFKKASAAWIIRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDA0</accession>
    <name>A0A398CDA0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4180 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00673">
        <property type="protein sequence ID" value="RIE00673"/>
        <property type="gene ID" value="D3H35_27315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025438">
        <property type="entry name" value="DUF4180"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13788">
        <property type="entry name" value="DUF4180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4180" evidence="1">
        <location>
            <begin position="10"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="122" mass="13620" checksum="9DAD7B848F5030F5" modified="2018-12-05" version="1">MNIAKVEAGGRCIAVVSGSEILIGDVQDALDLMATVRYEADCDHIVINKSLLSESFFDLKTRLAGEILQKFINYRLKVAIIGDFSTYTSQSLRDFIYECNSGNDIFFLPTEQQGIEKLSMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDE0</accession>
    <name>A0A398CDE0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_28925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00435">
        <property type="protein sequence ID" value="RIE00435"/>
        <property type="gene ID" value="D3H35_28925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="PTHR31632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="304" mass="33812" checksum="700FB07BAA7A0B8A" modified="2018-12-05" version="1">MGLQSFLITFREAFEAILIVGVILTYLKKIGQTKWNKWVWVGVLLAIVASYGVALLFQTVLTGFSTMGSQNYLKIGIMLVSSVLLSHMVLFMSRQSRDMQGEVENKVAAILTVGGALNMILHSFLVVVREGVETVFFFAAITGGDIQRALQSKGALYGLLLALIIGYFFFKGTRRIPLKAFFRITSVFLLMIAGGLIVQAVGIMQDIGMMGTLYRTPGGEIGELYNITAFMPEHPLDETQYIRDTGEHPLINGQVGIFFKAFLGYTQNPSVEEFALYWGFYLVLFILLGVQKKKDEKRQTSRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDV6</accession>
    <name>A0A398CDV6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000043">
        <property type="protein sequence ID" value="RIE00893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00893">
        <property type="protein sequence ID" value="RIE00893"/>
        <property type="gene ID" value="D3H35_25910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="111" mass="12597" checksum="224AEBB5565E1215" modified="2018-12-05" version="1">MLEYQLYDGSTRAVGSKVYSNSLRSIQMNMPSVDGNYSLNLIKQNFPNDVVKLSGSIPISVVSNFKISISLPSGYELNPFGWNQSVEICRRTEKERISIRLSLISMEIWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF02</accession>
    <name>A0A398CF02_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01150">
        <property type="protein sequence ID" value="RIE01150"/>
        <property type="gene ID" value="D3H35_22345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="70" mass="8026" checksum="20C5749C46B9CEF4" modified="2018-12-05" version="1">MTNGRPLNSTTTMVLHIYNLTFQRFKMWNAAAVTVVFARKSSIELSGLLRYTFLIRQKQIVRGIAFSGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFN5</accession>
    <name>A0A398CFN5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA sulfur modification protein DndB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dndB</name>
        <name evidence="1" type="ORF">D3H35_24585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01533">
        <property type="protein sequence ID" value="RIE01533"/>
        <property type="gene ID" value="D3H35_24585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16412">
        <property type="entry name" value="dndB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017601">
        <property type="entry name" value="DGQHR-contain_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017642">
        <property type="entry name" value="DNA_S_mod_DndB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14072">
        <property type="entry name" value="DndB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03187">
        <property type="entry name" value="DGQHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03233">
        <property type="entry name" value="DNA_S_dndB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="366" mass="41560" checksum="23C5B7DB284310D8" modified="2018-12-05" version="1">MQNAFYYNFPAIRGIQAGKEYFISMCPMRIIPKIFLFDEEELQPEIRAQRVLNKSRIPEISSYIVQNPEAYVFSALTASVDGNIEFSPASDQPVHYNLGFIKIPMDAQFIINDGQHRRAAIEAALKERPELGDETISVVFFVDLGLRRSQQMFADLNRYSIRTTKSLSLLYDYRDPYAQMAREIISEVHVFNGLTETEKSTISNRSNKLFTLSGIHNATLDLLQDKNNLDLSSQTALAIEYWNEISKNINEWQLVKKGEVSAAELRKDYIHAHAVVLSAIGKAGRTLIQCYPHDWKAKLGQLKVINWHRNNVQWEGRALIGGKISNSRNNITLMAIELKRSLGLVLSVEEECAEKAYISSKKVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFU0</accession>
    <name>A0A398CFU0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HU family DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_23660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01370">
        <property type="protein sequence ID" value="RIE01370"/>
        <property type="gene ID" value="D3H35_23660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="90" mass="9502" checksum="FEBE02C89351B088" modified="2018-12-05" version="1">MNKTDLINNIAEKSGLTKKDVESVLNGFLDEVSGALAGGDKVQLIGFGTFETRARSGRVGRNPQTGKSIEIPASKVPAFKAGNKLKDAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFU9</accession>
    <name>A0A398CFU9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RadC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01593">
        <property type="protein sequence ID" value="RIE01593"/>
        <property type="gene ID" value="D3H35_24930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RadC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="56" mass="6188" checksum="F164FCF20D1C1C52" modified="2018-12-05" version="1">MIAIQVVAVGTLDSLLVHPREVFKTTILANTTHIVFMLTIVCRPLASAEEIIKLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFY7</accession>
    <name>A0A398CFY7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_26950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00822">
        <property type="protein sequence ID" value="RIE00822"/>
        <property type="gene ID" value="D3H35_26950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="84"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="327"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="412" mass="45471" checksum="C0B0DCC38514632D" modified="2018-12-05" version="1">MISVDQSHHGKQEVQNWFPQFAKMNDLHSPADFMFAVCLKSPLAILSAVLYLKERGGSVLLLNGETPLQTAKEIAKRAGSSFLLHETCREIIPLGRKASREEPSLFQCSSGTSGTPKLIRRLWKDVDVEIDSYNKAIAWADSDIPLILVPVYHSFGLVGMLAALARRVKPIIVVDKNPKHIAKMVRSTRNAVVYGVPFLFHLAASFQKEPLHFYKIISSGSPLTDDLLQTIKKNSQQVYQQYGCSEIGCISIADDPASASDVGKPLPHLEVAVAERESDFHEVVVSFGNNTICTGDIGFLSPDGSLQIYGRLDDLICVSGLKVAPLEVERVITSMPGIAEAVVHRTKHPVWGEAVKAIIVRSGLMSAEEVRDWCKWHLPPYKVPGVVEFVKEIPRPPSGKISRKYLSERGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG66</accession>
    <name>A0A398CG66_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mRNA interferase</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_25615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Toxic component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PemK/MazF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00942">
        <property type="protein sequence ID" value="RIE00942"/>
        <property type="gene ID" value="D3H35_25615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033490">
        <property type="entry name" value="MazF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR033490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="116" mass="12906" checksum="BC0EFA8E0F033E1E" modified="2018-12-05" version="1">MIVKRGDVFYADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIEAKTHGMERDSVVLLEQIRTIDKQRLTDKITHLDDETMRKVDEALQISVGLIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG93</accession>
    <name>A0A398CG93_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01520">
        <property type="protein sequence ID" value="RIE01520"/>
        <property type="gene ID" value="D3H35_24520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="126" mass="14283" checksum="1AA1836A601B98FE" modified="2018-12-05" version="1">MDGQDIDLKVLVGKRVRQLRKIQGWSQSELAFRADMQESYLAGMERADRNVTLDSLARVLTALGVEPIEVFRFGELEIGKGLEGKQAAIRLHAAFLDERSLEEVELIRRLAKDVMATIDSQKKKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGD1</accession>
    <name>A0A398CGD1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prim-Pol domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_24490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01515">
        <property type="protein sequence ID" value="RIE01515"/>
        <property type="gene ID" value="D3H35_24490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="2">
        <location>
            <begin position="11"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="952"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="979" mass="110224" checksum="9A22C6ECA4D62518" modified="2018-12-05" version="1">MTPYKTIHQAAQRYAELGLRVIPLCSYNHHGMSEKHRHDCTKSGKAPLIGNWTARASNDPKIVAEWFDKYMAANVGVLTGVRGGIVAIDVDGDYGREQLEIISGGKIPATWEFTTPGGGHRYLFLAPEGVPLRKYSDSLPGAVHQELNFLIDGQQTVMPPSRHKNGGTYLWVDGHSPDEIELAAAPDWMVQKMSLALALDVLFDDSDTSSNNGSGQSIKQQLDNKPTQSKTSAGRTSNSPSSNRNEKDEILRNQCAKVSEAWELQNGDGCDWHKWFHTASLLVKAGSVEDALAFSEASSKKHNENSRTEIENMTKKDFGPTRCTTLGCDADQIKRCFGKLRKNEKNEITNSPVAFLKAEKSSNTGDIAELVKTFTRYRVQHGAIGQVDVNKSGDEVFKPFANFVAVPEEEVCLDDGATQERCFVVTGVLLDDDTMLPPLRVDHQDFHDPTKWVIRWGLRPTIFPGNYNKDRVRHTVQLLSHRVKNTVVYTHLGFRNIDGEWKYLHAGGCSDDNNVQVEVDSRLSRYILPSEEPDPIAAVERCFDLLEVANERVTHPLIATMFLAPLCEILRKIEIEPAFVVWLYGQTGAMKSTISALFLCLFGRFTAKSPPASYRDTANSLERRAFACKDSVLWIDDFHPTQNPLEARKMEQTAQSHIRAYGDRVARGRMRADATLRQDFAPKGLALDTGEQLPYGHSSNARLLGLELLPKDVNKEKLTKAQLHAPHLAEAMLGYTRWLGRQMTNNDLSRQLKETFAAKRSEAESSSSHGRIAETIAWLFLGLQSFLNYAVYIGAVTEDERKYRLVNGWRILLSLADSQSESVRESMPTTQFMDTVSELLQNRTIYVRSLNSPYESEKDFPGKHVGWHDKDYYYFLPTVLYNEVSSFLANQHEHIPLKMAALWKQLEVEGALSTETYMENGVEKVKRIRRKTVRGVRVPVLWIKKESVAVPDETEARKRDKRTRAVTQKSEPGNLFDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGQ0</accession>
    <name>A0A398CGQ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Efflux RND transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01635">
        <property type="protein sequence ID" value="RIE01635"/>
        <property type="gene ID" value="D3H35_25180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="118" mass="12280" checksum="87B33AD8984AA122" modified="2018-12-05" version="1">MEQTDKVSAKVESYLKELNETESYSVSIGSSGGNPLASSGGKNKATVTAQFVDGTDIDQLVDRMNTELPAIVTAEEEGTAINVKAGEQEGLVTGNNIDVSVFANNADNLAKAASKLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGS2</accession>
    <name>A0A398CGS2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01655">
        <property type="protein sequence ID" value="RIE01655"/>
        <property type="gene ID" value="D3H35_22160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="134" mass="14627" checksum="F1AAA45B112DC96D" modified="2018-12-05" version="1">MKSTVQSTTNAEPSPIKNKVGSLFIPVTNIEKSREWYCRLLGLPADCEIMNGHLCPLPMDGTSIILDTMPMWGGKEPGGAPAIKTPAFTLLTSDLQGAFEFVKENDIALATGIEHDHWFVIKDPDGNLLMVAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGU0</accession>
    <name>A0A398CGU0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">APC family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_14425</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01963">
        <property type="protein sequence ID" value="RIE01963"/>
        <property type="gene ID" value="D3H35_14425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="605" mass="66637" checksum="315EB8DE80E49ADD" modified="2018-12-05" version="1">MVSRLKRFLIGKPMKSTHLEDEKLSKLKALAVLSSDALSSVAYGTEQILLVLITLGFAAIWFSIPISIAVLGLLLILILSYRQTIFSYPSGGGAYIVAKDNLGTASGLVAGGSLLVDYILTVAVSSSAGTDAITSAFPSLHDYRVPIALIVIALLTILNLRGTTESASVLAYPVYLFVAAVFVLIVAGGVKLMVEGVHASIPEWGSAVNNISLFILLKAFSSGCSALTGVEAVSNAIPNFKKPAEKNAAMTLVMMGIILGVMFLGISLLAYGFGIAPNEKETVVSQIANATFGRGVIYYAIQAVTALILFLAANTAYSAFPLLAFMLAKDKFMPHMFKVRGDRLGFSNGIIMLGVLSALLIILFHGDTENLIPLYAVGVFIPFTLSQLGMMIRWLKVKPAGWPVKLAINTIGMLTTLTITLIFIFTKFSQVWMVFVFLPIVIFGFFRIQRHYMNIADQLRIDIDEEKPHIKGSTIVIPVAGITRVVLHSISYAKSLTDNVAAVYVGFDEEEIRRMEEKWEQWNPGVRLIVLRSRYRSVMRPLIKFIDTVEWKTAETDHITILIPQFITKHWWQNLLHNQTSLLIRAYLYNQKDIVIATVPFHLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGY3</accession>
    <name>A0A398CGY3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_28330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00339">
        <property type="protein sequence ID" value="RIE00339"/>
        <property type="gene ID" value="D3H35_28330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="2">
        <location>
            <begin position="685"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="773" mass="83788" checksum="A08F115E066994C1" modified="2018-12-05" version="1">MKYRNASAPLKERVEDLLGRMTREEKIGQLCQPFGWHSYRKNGEGGVEVTESFRREIAGRGIGSLYGTLRADPWTEVTLETGLSPGQGAEAVNVIQKYAIENSRLGIPILFGEECSHGHMAIGATVFPVPLAIGSTWNVELYRRMCRAVALETRAQGGAATYSPVLDVVRDPRWGRTEECFGEDPYLIGEFAVAAVEGLQGDSPDGTDSVMATLKHFAGYGFSEGGRNAGPAHMGMRELHDVDLYPFKKAVEAGALSVMTAYNEIDGVPCTSSSYLLREVLREQWGFDGFVITDCGAIDMLASGHDVAEDGGHAAALALKAGVDMEMSGRFFGDYLAGELEGGRLSEAELNEAVGRILSVKFRLGLFERPYVDPERAALVVGSREHAELARQIAREGTVLLKNEAGTLPFDSRTVGTVAMIGPNADNVYNQLGDYTSPQPRGKVATLLEGIREKLGPERVRYAPGCRVTGGNRDGFESALECADAADVVVLALGSSSARDFGEGTIDLRTGASVVRADAESDMDCGEGVDRTRLSLSGVQLELMQAIRALGKPIVVVYVNGRPIAEPWVDEHADAILEAWYPGQEGGRAIADILFGEANPSGKLTVSVPKETGQLPVHYNGKRSRGKRYLETDLKPRYPFGFGLSYTEFVYSDLQAGSWKEEDDGAFRARLSVRVTNAGGTAGAETVQLYVKDDVSSVARPVKELKGFHKIWLEPGEAREVEFIIEREHLMFTGQHYRLVLEPGTFTLTVARHSDDSDGLSATIVVEDEGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH26</accession>
    <name>A0A398CH26_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_13285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01770">
        <property type="protein sequence ID" value="RIE01770"/>
        <property type="gene ID" value="D3H35_13285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="406" mass="47080" checksum="BB70A748CF99942D" modified="2018-12-05" version="1">MSDGESIIFLLSVPRSGSSLTTAILNNHPDVFAAPESWLLMKLNDLLLPLPNKYGGEKIFQTFINGIMGEALQEEAMRAFVDKTYHGLASANGATLFLDKSPRYYTVLELLDRLFPASKRIWLIRNPLSVVASYKMLDVKRGTPFSEKLFKQKEFSMRVFDLTYGYWRYYHYFHNSSSEQVYRLSYEKLTEQPLEETVRLCTFLNIPYIDRLERYGERRDEAKKALLTASHSGDPYVWKHNEPHQASVDLWKTELSSEEIAAYMNIMGTRLFEELGYGQVVAEAERITGTSFPREPDEEWLKMRHDQWLQQFPQPIPLSYNIKIRPSSNELSQGSTGPTISARPTTGPATMEVNQLKVALRASELKRERIEMDLEKLKRRNIEIKRRIPFYSILAPIVRRILLKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHS4</accession>
    <name>A0A398CHS4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">purE</name>
        <name evidence="7" type="ORF">D3H35_16635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02343">
        <property type="protein sequence ID" value="RIE02343"/>
        <property type="gene ID" value="D3H35_16635"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="6">
        <location>
            <begin position="3"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="162" mass="16681" checksum="15D2A050B7135C21" modified="2018-12-05" version="1">MSALVGVIMGSTSDWETMKKACDILDELGVPYEKKVVSAHRTPDLMFEYAETAAERGLKVIIAGAGGAAHLPGMVAAKTVLPVIGVPVQSKALNGLDSLLSIVQMPGGIPVATVAIGAAGATNAGLLAAQMIGSFDSEVQARVAARRERITQDVLDNAELPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHV1</accession>
    <name>A0A398CHV1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar basal body protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_14740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02020">
        <property type="protein sequence ID" value="RIE02020"/>
        <property type="gene ID" value="D3H35_14740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="3">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="4">
        <location>
            <begin position="191"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="271" mass="29214" checksum="B00F50D502685D7C" modified="2018-12-05" version="1">MNNSIISASVSMGALQKRLDILADNIANVDTVGYKRKSAVFEDIMTSLQSQQEDFRLDGRRSPLGYTHGWGSRIASIQLDMTQGSLKDTGNPTDVAIEGNALFEVRTTDGASAYTRHGAFQLIAQPDGDRVLLTDTGLPVLNSNGAEIRVPNGYELKIEENGTLTANGPQGSQPIDLGKLSLVQVTKPEFLVSVGDNLYGVPADVNVDDVLQNLIELPQGVAVRQGFAEQSNVSWGDEMSDLLLVQRAYQLSARALSSSEQMMGMANNLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHX4</accession>
    <name>A0A398CHX4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphosulfolactate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_26455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphosulfolactate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00739">
        <property type="protein sequence ID" value="RIE00739"/>
        <property type="gene ID" value="D3H35_26455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003830">
        <property type="entry name" value="ComA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036112">
        <property type="entry name" value="ComA_synth_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02679">
        <property type="entry name" value="ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102110">
        <property type="entry name" value="SSF102110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="272" mass="29922" checksum="E6BF57F879E98F5B" modified="2018-12-05" version="1">MEISALTKWPKALADPSGSRASKPRSAGLTMVIDKGLGLHSFAELLETADEYIDIVKFGFGTSPLYKTPVLRSKIELAKRHGITVIPGGTLLEIAVSKDVVPAFFRQILTLGFDGIEVSDGTITLGRKDRDELIRDGSALGLRVFTEYGKKLFGSRIDAEQFAETAERDLAAGAELVTVEARESGVGVGLFDERGMCRQQDLESMLRLIPFPSRIMWEAPQKEQQVALIKALGSDVNLGNILVNDVMALETMRRGLRSDTFDHRLAYSDYMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIJ9</accession>
    <name>A0A398CIJ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02205">
        <property type="protein sequence ID" value="RIE02205"/>
        <property type="gene ID" value="D3H35_15810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="166" mass="18724" checksum="34C5963B6DEBD658" modified="2018-12-05" version="1">MTETAVKRWYARGLRSHFHLLRVLGFLLGILLLIGWGLVSLERSPAGQGLDSSKWQWASASSFQEAAPPDQGWIPLSSRPDLHNESRYYWLRIPLAYDDEAPLLREPTLWVFNTPSLRVFDRGNGCFPTTRRSGAIGSTCSPTGTQRRFPHLFHPSCTCLSTTAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIN7</accession>
    <name>A0A398CIN7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01059">
        <property type="protein sequence ID" value="RIE01059"/>
        <property type="gene ID" value="D3H35_21760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="86" mass="10080" checksum="70E6A4848B0548A9" modified="2018-12-05" version="1">MEDKARFEFFRTYGLEKELDKIKRDLGRFGVRFDEWYSETSLYETGKVVEALDALRAKGQVYEQDGAVWLSSTTFGDDKDRVLVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIQ8</accession>
    <name>A0A398CIQ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Patatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_26505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00748">
        <property type="protein sequence ID" value="RIE00748"/>
        <property type="gene ID" value="D3H35_26505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="8"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="39"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="199"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="319" mass="34688" checksum="934FFCDFB90F562B" modified="2018-12-05" version="1">MAATRVNAVFEGGGVKGISLTGAVKAAEQAGICFHRVAGTSSGSIVASLLATGHSASEMKSIIESTPFRSFLKQSPIFRLKVIGPAIRLFLRNGLYSGDALELWIGKLLAAKGVVRFGDLPKGALRIVASDITNGKLLVLPDDIALYGIDPERFSVARAIRMSASIPFFFDPVILRTPIAAAKAHEKIKPKLNLTYVVDGGLLSNFPLWVFDDDDDTDLAERRIPVIGFQMVGKNDSHPNAIRGPVTMLKAMFETMLSAHDERYIEDHNRARAIKIPTLGVSTTDFGLSKEKSEQLYLSGLAAGEKFFKQWNRDTGKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIW3</accession>
    <name>A0A398CIW3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YafY family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_22275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01139">
        <property type="protein sequence ID" value="RIE01139"/>
        <property type="gene ID" value="D3H35_22275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="305" mass="35117" checksum="470C393460D43D22" modified="2018-12-05" version="1">MKLERLISMIYMLLNNEIISASELADKYKVSQRTIYRDIEAICAAGIPVVSYQGVNGGYGIIEEYKMDKSLLGSYDVGSLITLLQSMSTVFKDEKAMETVRRLQTIRKDNGAPSLSMEIGNRRVSNQGLRLLRTAITARQLVRFDYIDAKNERTNRRVEPVSLLYKNHTWYLYGYCRTREDYREFKLSRMMELASLPEVFQRAHDAAPSNNAYEWMERHRRAEVVLNVSANSLAKAMDAFYDATRNFNEDGSLTLILKIDDIAASDWLISILLSFGEGVEIVEPRELRRQFKAKLEKMIGRYSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ55</accession>
    <name>A0A398CJ55_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NlpC/P60 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_15415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02142">
        <property type="protein sequence ID" value="RIE02142"/>
        <property type="gene ID" value="D3H35_15415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017448855" evidence="2">
        <location>
            <begin position="29"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="48"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="176" mass="18557" checksum="949D1B5879645A2D" modified="2018-12-05" version="1">MNHLQAWKKLLIGTACFAVIAAGSTAAASPSTFAATTSATASASSTAAQKADKLIAKAKSLQGKVRYKYGVNSPSTYTFDCSAFTKYIFASQGVTLKWGSSAQSKQGTYVSKNNLRKGDLVFFSVGTPGKINHVGIYIGSGKFIHNTIGGSVNGVIISDLNSGNYPKRYITARRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJF3</accession>
    <name>A0A398CJF3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_16150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02262">
        <property type="protein sequence ID" value="RIE02262"/>
        <property type="gene ID" value="D3H35_16150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="221"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="323" mass="37886" checksum="6393D71ED898FB67" modified="2018-12-05" version="1">MTEPHRNDLQNRKKTGAPFPFARMARKRNALDRLDLQFRWGRYGIRVLRCHLMAFEPGQVIGFHKHSEFEFHFIPKGKGTVTIQDRKYELGEGLFYLTGPDVIHEQRSDDEDPMFELCLHCEIVELDRAAEAEWGDKLEEREAEECVRLLQTMPPEPALDRYQAMNCFLDAYRAWEEQPVGFYTTMKQTVLQILLRAARVHAAPGDSGNIPERDMKDHRFRLATQFIEDNEARPLTLEDVAEKVRVSPRQLQRIFRSEGNSTFHDWLEHARLQKICSELLQTDRPIEDIALDHGYSTPNYLYPVFKKKYGMTPSAYRRHHGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJI3</accession>
    <name>A0A398CJI3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Esterase-like activity of phytase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_17435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02480">
        <property type="protein sequence ID" value="RIE02480"/>
        <property type="gene ID" value="D3H35_17435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027372">
        <property type="entry name" value="Phytase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13449">
        <property type="entry name" value="Phytase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017263455" evidence="1">
        <location>
            <begin position="25"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="2">
        <location>
            <begin position="35"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Phytase-like" evidence="3">
        <location>
            <begin position="106"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="484" mass="52554" checksum="D4BA993A7C030AA0" modified="2018-12-05" version="1">MKKKGLLVVTTALALTAGTGIVSAAVLSGNTAEQINYSNNGQTVKPSSPAVNIDGHLYLPIRALGETTGKYVDWDEFRSGVSLTDKPQLTGKYKLNAPNLADGIKMGVGSSLTHLPGDPDNVFYSTADRGPNGQIEVGGKTVRTFPLQDYTPTIYKIEIKDGEINILDQFPLKVQGTDPVTGKANVTGLPNIKGRDEAPYDAKGEKELAYDPYGLDIEGLAYNPKDDTFWISDEYGPSIVHVKRDGTIIERIVPKGWAAQASASLVPSRETLPAVYNKLRQNRGAESVGITPDGKYMFMAMQNALRNPDKAMDNSRQVRIIKFDLATLNPVAEYAYLLEDAGAFDKLAQADIVVSDLVAVNENTLLIDERDKFAGDKAQLKRIYSIDLSNATNILGKYDDAAAAGKTLEQLTVAELKANGILPAAKRTVLDAVEFKFPYEKIEGLSLVNGNTLVIVNDNDFGIDSTTPENGTELWTFKLPYTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJJ3</accession>
    <name>A0A398CJJ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_17490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02490">
        <property type="protein sequence ID" value="RIE02490"/>
        <property type="gene ID" value="D3H35_17490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="2">
        <location>
            <begin position="125"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="328" mass="37214" checksum="1191DED6CB05C246" modified="2018-12-05" version="1">MNSQLRTFLSLADAVIITDEEHTILAVNAAYETITGYASDQIIGKGAGVLRSPYTPASTYKSMKEAIHSGSSWSGVFTNHKRNRELWHSSITITPFEMEGTTYFVGMFRELEQLDRGYYLDDERVGQIQGSLLKVLAISCEIRDPGIESHLLRVQNLTEQLVRKHNDRLGLKLRPSYLSRIAHSSILHDIGKSSIPEGILYKPGPLADYERKIIEMHTLIGVDIVDKIYAELDDELFESELATAKNIILHHHERWDGTGYPHRLQGDQIPLEARIVSVVDVFDALTTKRPYKEKWDAETALRYLTEQKGKQFDPEIVDSFLAMNTVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJQ9</accession>
    <name>A0A398CJQ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01409">
        <property type="protein sequence ID" value="RIE01409"/>
        <property type="gene ID" value="D3H35_23865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045509">
        <property type="entry name" value="HD_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19276">
        <property type="entry name" value="HD_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="58"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="428" mass="50405" checksum="8CE244193DFCAC9A" modified="2018-12-05" version="1">MFRQLEEEKVFKDPVHQSIYVQDATIWKLINTPEFQRLRRIRQLGTSYLTFHGAEHSRFSHSLGVYEITRKIISQFERNGYSDWPQQEKLVSLCAALLHDVGHGPFSHSIEQVFDTDHEDWTCEVILGNTGVNRVLREVSADFPDKVASVIRKTYDKPIVISLVSSQMDADRMDYLLRDAYFTGVHYGTFDLERILRVLRPYKDKIVVKESGMHAVEDYLMSRYQMYWQIYFHPVTRSSEIVLRQIFRRARELYAEGYEFGFMLPPLRQLLQGTLSVEGYLQLDEALVQTAFGQWMEEKDELLSDFCRRFLNRVLYKYIPLEQRDETWLNGLRDEWKSIGLHPDYHMEVDTPIDLPYDVYKPGEDSPEKPPILLLDDREGLTEIASKSEIIQSITGLHRGKYFLYYPEDLVRPHASKLSRLTRERLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJR9</accession>
    <name>A0A398CJR9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Stage V sporulation protein AD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">spoVAD</name>
        <name evidence="1" type="ORF">D3H35_21950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01088">
        <property type="protein sequence ID" value="RIE01088"/>
        <property type="gene ID" value="D3H35_21950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010894">
        <property type="entry name" value="SpoVAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038369">
        <property type="entry name" value="SpoVAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07451">
        <property type="entry name" value="SpoVAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011570">
        <property type="entry name" value="SpoVAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02845">
        <property type="entry name" value="spore_V_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="338" mass="36105" checksum="84EAE00DA954909F" modified="2018-12-05" version="1">MLKGHQSWIFRRRPVITGTAAVVGPFEGRGPLGDDFDIVHGDSMVGQDSWEKAEQALLEEAANVAIQHAGITKEQVHFHVGGDLMNQITSTSYTARTMTIPYIGVFGACSTSMESLALGAQLVDSGAAKHVLVGTCSHNSSAEKQFRYPTEYGSQKPPTAQYTVTGAGAAVVSDEGDGPVVVAATIGRVVDMGIKNPFNMGAAMAPAAVDTITAHFRDLQVGPDHYDLIVTGDLAKVGYEIASDLFEKHDIPMHKTRYRDCGMLIYDYEKQMVQSGGSGCGCSAVVTYGHLIKKLRKREFRRILVVATGALLSPIAMQQGETIPGIAHAVAIEAPESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJV1</accession>
    <name>A0A398CJV1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_22200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01128">
        <property type="protein sequence ID" value="RIE01128"/>
        <property type="gene ID" value="D3H35_22200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="98"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="196" mass="21922" checksum="B84C31FCE019FD6B" modified="2018-12-05" version="1">MAAGSDPAAFSVQLVECDRLAQRVRYDAHAGFAGSVRQVSPGKLRSRNLDRFVPLRQELDLVRAYLFIEKERFEDRLRIVWEVDEHMGMEVMIPPLSIQPLVENAVRHGILKRAQGGEVRIRIVDRGEYAEVTIADNGVGVEESAMRRFRDGQASEEGRGIGLGNTDRRLKQIYGRGLRVDSTPGQGTTVSFSAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK07</accession>
    <name>A0A398CK07_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cupredoxin_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_18340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02640">
        <property type="protein sequence ID" value="RIE02640"/>
        <property type="gene ID" value="D3H35_18340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Cupredoxin_1" evidence="2">
        <location>
            <begin position="65"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="149" mass="16027" checksum="2E2D062BE28BB56F" modified="2018-12-05" version="1">MNKVVILSRKKIQFYAILAVIVVIAVSLIGWQQSRPASAPAHDGTQVYQLVTGEFNATTDSGEKLESYGFHPGVIIVKKGSPVELRITGINGQTHPFVIEGLGITGEVRKGKTTVVRFTPKEAGTYSIICQTHSDSKSGGPMVGYLIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK09</accession>
    <name>A0A398CK09_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fe-S cluster assembly protein HesB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03646">
        <property type="protein sequence ID" value="RIE03646"/>
        <property type="gene ID" value="D3H35_10115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="91" mass="10181" checksum="0A81BAA6A2BD72DC" modified="2018-12-05" version="1">MELTVTSSALACFKKEWGFDEGEHIRVFVRYVSGGESPFAFGISRDTPQEAALTTTAGKLTFFVERKDLWFLDGSSLVLDCRGEDIVFHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK62</accession>
    <name>A0A398CK62_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bactofilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02690">
        <property type="protein sequence ID" value="RIE02690"/>
        <property type="gene ID" value="D3H35_18705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="223" mass="23950" checksum="D0B3E0C9008BDE7B" modified="2018-12-05" version="1">MADETRQDLKMVGTTSSGGGRFRSVKITGESVLNGAVDCDKLACTGELVVKGELRSDEVKVMGECRIEGPLNAGSVRGQGEIEVKASARVETMKMTGNVDVGGHFESGDLRLFGGFRVEGLLSAERLELRMYGPCRAKEIGGGTLIVKRSRAAALAKWIKPHSQAMLNVDIVEGDSVELEHTTAGIVRGNRVVIGPGCEIGRLEYRDSLVLHKNAIVKDQVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKB7</accession>
    <name>A0A398CKB7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_16245</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. EmrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03153">
        <property type="protein sequence ID" value="RIE03153"/>
        <property type="gene ID" value="D3H35_16245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="1"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="470" mass="50653" checksum="9E547FF1C12AFB94" modified="2018-12-05" version="1">MVAIFVGSFLVVLASATINIALPILVEHFDSSLGTVQWTLTGFMLAMGTTAPIVGYLGERFSYKRLFLYSLIGFTLASALCAAAWDIHSLIAFRVLQGAFSGLILPATMSVIYQVIPKEKQAMAVALWGLAAMLAPAFGPTLSGWLLQNFAWEWLFLMNIPIGIVAVLLVARYIPYYRLSIPKSFDAIGFITVIVSSSSLLLALGQGHNWGWDSAKVIGLLALGVLSLIAFIFRELTAKSPLLNLRVFRNGRYTISLVITNILTISLYSGTFLTPVFLQNIQHVSAMDTGLILLPASLVMALVMPIVGKLYGVIGPRWLMSAGIVLLAVGTLTLSWLSIDVPHSYIVWWMTVRNLGIALVMMPSSNAAMERIPAELSGHASSVLNWTRNVFGSFAIAVFTTMLASYSTSHATDMAMAGDTDKVHIASMAFTMSVNDVYVVATIVAVVALPLALLIGKAKKGAAEQVRNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKD4</accession>
    <name>A0A398CKD4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rrf2 family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00347">
        <property type="protein sequence ID" value="RIE00347"/>
        <property type="gene ID" value="D3H35_28390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017317320" evidence="1">
        <location>
            <begin position="26"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="151" mass="16533" checksum="4FDDE4B8F989664D" modified="2018-12-05" version="1">MKQISNRFSIAVHILSMVAVMPAKCTGDFIASSVNTNPVIVRRIMSMLKKAGLIKIRPGVGGSNLLKEPEDISLLDVYRAVDVVEDGHMFNFHKDPSQACPVGKTIEQVLRRELTEAQSAMEQRLSQTSIRQVNEQVLAASGLSGHMDSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKS0</accession>
    <name>A0A398CKS0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCO family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_19100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02752">
        <property type="protein sequence ID" value="RIE02752"/>
        <property type="gene ID" value="D3H35_19100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="PTHR12151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="33"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="204" mass="22974" checksum="5CCA6E3D60EEABDB" modified="2018-12-05" version="1">MFPKKYGFPLAVLALCLILGGYLLWSQKKDSELPIEQQGAPFSYTDLDGQTVSLDNTNGKVRLLYFFFANCPDVCPPTTFMLSQVQNQLKEAGLFGDKAQLLSVTIDPARDTVDSLKKFGDQFNADYSGWKFLRGDEKATEELAKKYQIWVSKDSPESFSHMNLIVLLDKKGQVREWISAKDYIEMGADNLPVSNIVDKIKSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKX0</accession>
    <name>A0A398CKX0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">secF</name>
        <name evidence="10" type="ORF">D3H35_27740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00537">
        <property type="protein sequence ID" value="RIE00537"/>
        <property type="gene ID" value="D3H35_27740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE00537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="301" mass="33601" checksum="3039B5AC01A99BDA" modified="2018-12-05" version="1">MHSNKKFNFVHTSRTFLMISLIITVLGIAAVGIFGLNYGIDFSAGTALDITTNKQVEKAKIESFLDEQKLGEYTLVTSDNRASVRFKAALNDVQEKKIKADFSKQLDDKADYEMHIVDAEIAREQQRSALIGMAVACLGIVLYVSIRFEWRFAIAAVLSLIYNAFFVIAVFSIFRLEVNLPFILAVLTIIGYSINDTVVIFDRIRENLRFAKIKSTSDLDVLVNKSIWQTLARSINTVITVLIAAVCLFIFGSESIKLFSLAMILGLVSGAYSSIFIASPIWLYLKKKEPLKKAVKTSNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKX1</accession>
    <name>A0A398CKX1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_19510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02822">
        <property type="protein sequence ID" value="RIE02822"/>
        <property type="gene ID" value="D3H35_19510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="3">
        <location>
            <begin position="137"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="402"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="447"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="530" mass="59718" checksum="6A1B4DF649AC41A0" modified="2018-12-05" version="1">MRHNYSSATRQQPPLCSNASHLLPVYPPSASVVLECITTTPRLPADSFRCARTRHIYSPTTRRQPPLCSNASHLLPDYPPDSLRYAQMRHKEPPPFLLHSGMQPANPAYVQDVYVFFVFPRAPEVVAVLNKLSLLAVSFNQENTIERCLTSVKFIADELIVVDLGSTDRTKEIALSCGANVLDYSGNGLNSDAHNFGLELATGDWILHTSPDEYLDPQDRYKLRDALYEEDKELMLLPVVLHPSKDGTAAQGREFARTRLFRNGSGFRFTGKIHGMLNFEEKMASAEALNKFGSLAVRIHHAPTTGLLQKHKMKAAKNDPAPSIAKSPFTAYHMACECYRAHLHEEAVQHLNQSIRLFLDLGYRVPPSFLYKLKYHIFARYLTKNDSTRGLQAALRIYPDYAELHYDMGLICMSRQAYDKAVNHFNECLALGERQSEYLVQQGTGSYAAAYNLGLCLEKKGRYDEAVQSYHEAVRMRHSYSPPLHALNRVADKHRIDVISSLAEDARLSTEQLEALIKAAPVRAKDPLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL55</accession>
    <name>A0A398CL55_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="9">Peptide methionine sulfoxide reductase MsrA</fullName>
                <shortName evidence="9">Protein-methionine-S-oxide reductase</shortName>
                <ecNumber evidence="9">1.8.4.11</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="9">Peptide-methionine (S)-S-oxide reductase</fullName>
                <shortName evidence="9">Peptide Met(O) reductase</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">Peptide methionine sulfoxide reductase MsrB</fullName>
                <ecNumber evidence="8">1.8.4.12</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">Peptide-methionine (R)-S-oxide reductase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">msrB</name>
        <name evidence="9" type="synonym">msrA</name>
        <name evidence="11" type="ORF">D3H35_12005</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 8">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="9"/>
    <dbReference type="EC" id="1.8.4.12" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03393">
        <property type="protein sequence ID" value="RIE03393"/>
        <property type="gene ID" value="D3H35_12005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01400">
        <property type="entry name" value="MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MsrB" evidence="10">
        <location>
            <begin position="177"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE03393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="315" mass="36023" checksum="415DFE194DC6150D" modified="2018-12-05" version="1">MKQLATFAGGCFWCMVTPFEELPGIHGVVSGYTGGHKVDPTYEEVCSETTGHAEAVQIEFDPDLFPYSKLLDIYWRSVDPTDAGGQFHDRGHSYRPVIYVHNESQREEAEASKAALDASGRFDKPIAVAIEAASAFYPAEEYHQDYHKKNPLRYRYYRSGSGRDAFIKSHWNTKKDKEELRKRLTPIQFEVTQNNATEPPFRNEFYNNREEGLYVDIVSGEPLFSSKDQFDAGCGWPSFTRPIQESGVLEHEDFSHGMFRVEVRSREADSHLGHVFDDGPEPTGQRYCINSAALRFIPKDKLEQEGYGKYAEWFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLB1</accession>
    <name>A0A398CLB1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SRPBCC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03050">
        <property type="protein sequence ID" value="RIE03050"/>
        <property type="gene ID" value="D3H35_20910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="169" mass="19438" checksum="A6361C982D28456C" modified="2018-12-05" version="1">MSNKMTLKAEGQELTLERVFEAPRALVFKAFSEAEHLKRWWGPRGWTLTVCNIDFRPGGVWHYCMKCIDENQGDYFGFESWGKAIYHEIVEVEKIVYVDYFSDAEGNESDAMPSARITMTFVEQDGKTKLVSHALYESAEALKTVLEMGMEQGIAETWDRLAEHLQDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLH0</accession>
    <name>A0A398CLH0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02039">
        <property type="protein sequence ID" value="RIE02039"/>
        <property type="gene ID" value="D3H35_14845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011801">
        <property type="entry name" value="Swm_rep_I_cyn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028059">
        <property type="entry name" value="SWM_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13753">
        <property type="entry name" value="SWM_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02059">
        <property type="entry name" value="swm_rep_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="113" mass="12017" checksum="DF82A8964B153E7A" modified="2018-12-05" version="1">MDGASIVLTYNETLNPDTVPYADNYYATVSGSFRQVTGVSVSGTQVRLALQQGVVVGQSVKLSYTPQLNDASRHIQTLLGKEAAAFTNRDVTNTTSTTLPRPVSGSLSGRSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLJ5</accession>
    <name>A0A398CLJ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03130">
        <property type="protein sequence ID" value="RIE03130"/>
        <property type="gene ID" value="D3H35_14170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="26" mass="3137" checksum="A92F50F132E8E61A" modified="2018-12-05" version="1">MYAAIEKGFFKEEGLTLRWFSKISKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM28</accession>
    <name>A0A398CM28_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_25440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00917">
        <property type="protein sequence ID" value="RIE00917"/>
        <property type="gene ID" value="D3H35_25440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="128"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="128"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE00917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="228" mass="26646" checksum="F5086DCAB0238E16" modified="2018-12-05" version="1">MERILVVDDDPQIREVIRTHIEQAGMDAREAESGNQAIERMESEHVDVIILDLMMGDRDGFEVLRYLHNRKLDTLVIVVSARRQEQDKIVTLGLGADDYITKPFSPMELMARIQAVLRRRHPKSSHSSLVIRLNNMILDIDNFTLLVYNEKISLTWVECGLMQLFMQNPDRVMTKLEIYQQVWQHERYDDNNLSVYMSRLRKQLERAQSTWEIQTVRGVGYRLTGVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM81</accession>
    <name>A0A398CM81_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_16560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic sulfate-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02329">
        <property type="protein sequence ID" value="RIE02329"/>
        <property type="gene ID" value="D3H35_16560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901681">
        <property type="term" value="F:sulfur compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902358">
        <property type="term" value="P:sulfate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01005">
        <property type="entry name" value="PBP2_CysP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000957">
        <property type="entry name" value="Sulphate/thiosulphate-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034408">
        <property type="entry name" value="Sulphate/thiosulphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005669">
        <property type="entry name" value="Thiosulph/SO4-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30368">
        <property type="entry name" value="PTHR30368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00971">
        <property type="entry name" value="3a0106s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00401">
        <property type="entry name" value="PROK_SULFATE_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00757">
        <property type="entry name" value="PROK_SULFATE_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0574">Periplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017273155" evidence="7">
        <location>
            <begin position="25"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="341" mass="37987" checksum="A07100B5F036191A" modified="2018-12-05" version="1">MKNSFRLIVLTLFAFVLTTSTVFGAVTKKSEKKNVTLLNVSYDPTRELYVGYNAAFAKYWKKKTGQTVTIKQSHGGSGAQARSVIDGLEADVVTLALEYDVAAIEKKGLIAKGWQKRLANNSAPYKSTVVFLVRKGNPKKIKDWDDLVKTDVSVITPNPKTSGGARWNYLAAWGYALKHNNNSQDKAKDFLKKLFANVPVLDTGARGSTTTFVDKGIGDVLLAWENEAYLAKKEYGDKFEIVTPSLSILAEPTVAVVTKNVNKHDTRQVATAYLDYLYTEEGQRIAAKNFYRPINTKVAKEFEKQFPKLNLITINDFGGWDKAQTTHFADGGTFDQIYLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM85</accession>
    <name>A0A398CM85_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03763">
        <property type="protein sequence ID" value="RIE03763"/>
        <property type="gene ID" value="D3H35_09410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="82" mass="9796" checksum="17A32D1A215AF691" modified="2018-12-05" version="1">MIFAKKVGLRRQPQARQEFILKRGGHVYIVTVQHEKQMKALLRLHYKIGSGAKSIIIPRVRIFARFFCVNLRIFENRRKMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMA4</accession>
    <name>A0A398CMA4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Asparagine synthetase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_09525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03783">
        <property type="protein sequence ID" value="RIE03783"/>
        <property type="gene ID" value="D3H35_09525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="6">
        <location>
            <begin position="2"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="645" mass="74226" checksum="2993FE5CFD3F6FCD" modified="2018-12-05" version="1">MSAIVGIYQNDGESVPQDHGMGLMRALASYPSDDSRIWQHSSVFLGCHAQWITPESIGEILPCYDQQRQLAITADAILDNREELFEKLQVDRSIRKIIPDSQLILLAYGKWGDESPSHLVGDFAFMIWDEAERRLFGARDFSGNRTLYFARASGRFAFSTIIKPLFSLPYISNALNEQWLAEYLANPGRLETVDAGSTVHRQIEQLPPSHFISVTDGAVKISRYRTFEEARTLRLKNDGEYEEAFRDVFRTSVASRLRTFRQVGSFLSGGLDSGSVASFAAKALRRDNKQLFTYSAIPLKSFDDWTTKSRVADERPLIRSTVEHVGNIKDHYLDFEGKSPLTEMDEWLDTMEMPYKFVENSYWFNGIYETAKRNDVGVLLNGGRGNFTVSFGPALEYYVQLLKRLKWFTLHRELYLYSRNKGIGRRRLLGYMKDRLFPPRISPGDRSVLSQLIHPAFAERTQAYEKLQRNGIDLSGSAIPDMIHARTKQFEECYHWTNSGTSGTKLSLRHGMWYRDPTNDLRVIRFCLSVPIDQYVRDGMDRALIRRSTVNLLPDQIRLNYKTRGIQGADGIQRMAPAWKSFIREVDRLCEDREMAEWLNIPVVKAAASKYREVPDPRQIYTAEFTILMRSLIVYRFAHRLRGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMK5</accession>
    <name>A0A398CMK5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_27000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00831">
        <property type="protein sequence ID" value="RIE00831"/>
        <property type="gene ID" value="D3H35_27000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="182"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="267" mass="29365" checksum="52CD110606BCA33B" modified="2018-12-05" version="1">MILVPVYHSFGLVGMLAALARRVKPIIVVDKNPKHIAKMVRSTRNAVVYGVPFLFHLAASFQKEPLHFYKIISSGSPLTDDLLQTIKKNSQQVYQQYGCSEIGCISIADDPASASDVGKPLPHLEVAVAERESDFHEVVVSFGNNTICTGDIGFLSPDGSLQIYGRLDDLICVSGLKVAPLEVERVITSMPGIAEAVVHRTKHPVWGEAVKAIIVRSGLMSAEEVRDWCKWHLPPYKVPGVVEFVKEIPRPPSGKISRKYLSERGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMN5</accession>
    <name>A0A398CMN5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="4">dUTPase</shortName>
            <ecNumber evidence="4">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dut</name>
        <name evidence="6" type="ORF">D3H35_11650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03510">
        <property type="protein sequence ID" value="RIE03510"/>
        <property type="gene ID" value="D3H35_11650"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00116">
        <property type="entry name" value="dUTPase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="5">
        <location>
            <begin position="16"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="67"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="84"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="147" mass="15970" checksum="3E118C63EAEBBBB9" modified="2018-12-05" version="1">MYPIQLKRLPGNEDIALPRQMSEWAAGFDVQAAVTEPFVLAPGARALIPTGFAMAMPRELEAQVRPRSGLAYKHGITCLNSPGTIDADYRGEVKVLLVNLGQEPFTIERGERIAQVVFQRVPQVSISEVDELPDTVRGAGGFGHTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMT7</accession>
    <name>A0A398CMT7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Type II secretion protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_25345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00901">
        <property type="protein sequence ID" value="RIE00901"/>
        <property type="gene ID" value="D3H35_25345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="144"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="280" mass="30645" checksum="0795D8C680106E73" modified="2018-12-05" version="1">MLITMASAITITVYVVLLILALMARKERETAFHALTEPIGQLLLRTGWFVRLQPILRRQESALLLLREGKADRDALFRWTAESVGQGYAALMAFLLIGSLSGNAALAWIGLIVGAGLPLLRAKELQKRVESRRRRILIELPELLNRLLLLVGAGENVMKALIRSSERGSGAVAHPLYDQLNAALAAMNRGESMTVAMEEFGRRCAVPEAKLFATVLLMNARRGGETLAPALRELTRALWEKRKVVALTMGEQASSRLAFPLAVVFLVIMALAGAPALLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMW8</accession>
    <name>A0A398CMW8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DNA integrity scanning protein DisA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">disA</name>
        <name evidence="11" type="ORF">D3H35_29995</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00264">
        <property type="protein sequence ID" value="RIE00264"/>
        <property type="gene ID" value="D3H35_29995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01438">
        <property type="entry name" value="DisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038331">
        <property type="entry name" value="DisA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018906">
        <property type="entry name" value="DNA_integrity_scan_DisA_link"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023763">
        <property type="entry name" value="DNA_integrity_scanning_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10635">
        <property type="entry name" value="DisA-linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAC" evidence="10">
        <location>
            <begin position="11"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE00264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="363" mass="40874" checksum="0C1561046559A9C9" modified="2018-12-05" version="1">MKETKDKELVQQETMNQLLQMIAPGTPFREGLENVLRAKTGALIVVGYSPEVMELVDGGFSINSDFSPNYLYELAKMDGAIILSEDSKRILFANTQLIPNSSISSSETGIRHRTAERVAKQTGKLVVSISQRRNVITLYQGNLRYALKDMGVILTKANQAIQTLEKYRAVFTQALTNLSALEFEELVTMHEVAYVMQRAEMVLRIKTEIKRYVLELGNEGRLIQMQLDELVSSAEDEARMLLKDYAKDASDDKIKEIQACFKKLTSEELLESPGLIRLLGYASLSSVAEEGLLPRGYRMLSKIPRLPVIIIHNLVERFGALPHIVMATIEELDEVDGIGEVRARAIKEGLKRIQDQVFIDRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMX3</accession>
    <name>A0A398CMX3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02599">
        <property type="protein sequence ID" value="RIE02599"/>
        <property type="gene ID" value="D3H35_18115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="165" mass="19379" checksum="D5EAA22AC99002A1" modified="2018-12-05" version="1">MIANTYRIERLGSVADAERIVAFFFSPYSFDDTRHTPGEEEHFRTLPYRALEGEAVFWFVTNEQGDIVAVNSVKENEQKTGGYSWDYIVVHRDYRSEGIASRLIEAMFLFLEYSSARYVMTYTCSLPEYGTIRKLFERNGFELIGRCPDYYFEGEDRLIYCRKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN34</accession>
    <name>A0A398CN34_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D3H35_15775</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02198">
        <property type="protein sequence ID" value="RIE02198"/>
        <property type="gene ID" value="D3H35_15775"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012744">
        <property type="entry name" value="Nitri_red_NirB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017121">
        <property type="entry name" value="Nitrite_Rdtase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037149">
        <property type="entry name" value="NirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02374">
        <property type="entry name" value="nitri_red_nirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="13">
        <location>
            <begin position="4"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin_C" evidence="14">
        <location>
            <begin position="316"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="12">
        <location>
            <begin position="420"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="12">
        <location>
            <begin position="484"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="11">
        <location>
            <begin position="559"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="10">
        <location>
            <begin position="629"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="802"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE02198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="830" mass="89789" checksum="8959A512350BE603" modified="2018-12-05" version="1">MRRKLVMVGNGMAGVAFMEQLLKLNPNKFELTIIGAEPHPNYNRILLSSVLAGDAKLDEIVLNDWNWYTDNGIAFYAGHSVTHIDTFGRTVRTDRGVVVPYDELVLATGSLPFMLPLPGADKEGVIAFRNIEDCHTMIEAAREYKKAVVIGGGLLGLEAARGLLNLKMDVNVVHIFDCLMERQLDRTGSKMLQAELERQGMKFLLEKQSDAILGKKRVTGLSFKDGTRVDADLIVMAVGIKPNVQLAKSSGIEVNRGIVVDDYMQTSVPGIYSLGECAEHRGVVYGLVAPLYEQGAVLSKKLAGAETSGYAGSVLSTKLKVSGANVFSAGRFGDDPGTKSLRVQDDVEGIYKKVVFQDGKVVGAVLLGDTSESSKLFSLIRGGENFAGREREVLFGASGGGIGKPSSPVDLIAEMSGNEIVCGCNGVAKDTIVEAIREKGCVSIGEIKACTKASGSCGGCKPLVEAILISTLGADSVVDAKEGICGCTTLSRDEVVEAIARMKLTTTKEAMHVLEWANPEGCSKCRPALNYYLGMLFPEEHEDELESRFVNERNHANIQKDGTFSVVPRIYGGVTTPEELKRIADVAEKYEVPLVKITGGQRIDLLGVKKEDLPAMWKDLDMPSGYAYGKALRTVKTCVGNTFCRFGTQDAIGMGIAMEKKFERLNTPAKVKLAVSGCPRNCAEATIKDLGVVAIDGGWEIYVGGNGGTRIRAADLLVRVKTEDEVLEWTGAYLQYYRETGSWNERTSEWLQRVGIGQIKESLADPDARAALLGRIEKTLNLAKDPWQQIIENDDLRKAFDALTAKPPKPASGGADSKAQASLVEKPPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN58</accession>
    <name>A0A398CN58_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Germane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_08085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03915">
        <property type="protein sequence ID" value="RIE03915"/>
        <property type="gene ID" value="D3H35_08085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00909">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017388863" description="Germane domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Germane" evidence="2">
        <location>
            <begin position="139"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="298" mass="30975" checksum="47FCFE50F8A1D610" modified="2018-12-05" version="1">MKSSWTRKSRTRLLAAMLLLLPVVSACSLGGGGGEPDVADIDAPPASVEQSMLEQTDEQPSHPSIATVDNAQDGHAVKAGDAAGQAGQAGQVSQEAAGDTVTVYLLDRNGYVAPMTLRTAAESGGKEKGGDNAAGQTLAETALSWMIDNPERRDQLPPGFSALLPAGTKINSVVPDAESRSVTIDFAEPLTGLETGKDRKAIEALVWTMTELPGTDSVKLTVAGKPLQLLPGSSIPVDAKLTRGIGINVEAAKDVQTSARWELLCTSPPVPQKEKAISFLSRASSTVSPTAPEPPCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CND3</accession>
    <name>A0A398CND3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_28860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00424">
        <property type="protein sequence ID" value="RIE00424"/>
        <property type="gene ID" value="D3H35_28860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="755"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="803"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="846"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="19"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="341"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="785"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE00424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="883" mass="98022" checksum="9935C37A6EAADD27" modified="2018-12-05" version="1">MRNYTGLTEKYLWGQKKRSILTMIGIVLSVTLLTSIGTIATSYKDKLIRQTMQSYGDYHVSFNGIPGEAVSKVSNYATVGSAGIISREGYAVISETDEKEKKENPVTAPFRYLNVKRYDANAMNMLQVRLESGRLPENANEIILSSWGLNLFPNKPKLGDHIKLNLGVRTVASTGKEKAINGMGDFGWDLDEAFQARTQKEFKVVGIMKPPSNSAWSSAFIIPAITFNDNKAIDPDRPYFIYAKMKSMDQIKKKTESIVSSLKINDTDQGSALQLNRDNSIKNVRIEFNNELLKLYGKSTYDGVNKSSILALAAIIAIILICTFAVIYNAFHISVLERIAQFGILRCIGATPSQIRNIVLKEAAILSLVSIPIGLFTGTLFMKILFYSISFISLGFLNDMKMVVSIPILAFAGLLGLLTVYISAIGPAKQAARVSPLEAVKSSGNTNAEKITRIKKSAFMKKLLGLEGQFARRNLQRNKRRFRITAFSMIISVILFIVFSGIVDFLKQTSSSGMHYSYSINYEGPSKRIPDSVYQDVLKLEAVQKAYKFYNHQVEAIIPKNKINPNYYEVMKSMYSVDVGEGYRTGNNYLNSLGDNGLDDLKSKLIEGTIDREKMNRENGVIVLQKIAMITEKGKKLIIDQTNFKVGDQIQIRSPEEGKKEYTTVTVVGVADQELLSSGYSESHTVGFITTPKVIAKITGNDAFSRILIIANPDAPNAPITDYLQALIKQDAGYSYMDKVAESEQAKNDEMTSRILLYGFIGVIDLIAFINILNTVSTNLILRTKEFAVLKAIGMTQKQLNKMILLEGALLGVFAALNGILIGVALDFSIQRLFSDVVEMAWTIPWRNMGIAFAGAMITILVATIWPMRTLKKVNIVDALRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNQ2</accession>
    <name>A0A398CNQ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04233">
        <property type="protein sequence ID" value="RIE04233"/>
        <property type="gene ID" value="D3H35_06345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="160" mass="17829" checksum="F8C1FC7E172CC15F" modified="2018-12-05" version="1">MNKQSAAAGVLVLVAGLVILLGKLGVFAFIGTVFWPLFILIPGVLLHVLYFGRIVPSAVLIPAGILTIVSIVLLICNWFGWEAMRYLWPLFPFAIAVGLYEYYIFGYSRSRTIWTISVVLGGLSILLFALTLLWTWGIYLFAVVLIGVGAWLVLRRPKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNV9</accession>
    <name>A0A398CNV9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_06075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04185">
        <property type="protein sequence ID" value="RIE04185"/>
        <property type="gene ID" value="D3H35_06075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="255" mass="27702" checksum="B94F99618CEA735C" modified="2018-12-05" version="1">MQRYFVSPEQITDNTVTLEGDDARHLAQVMRSKAGDRFIACDGSGRDVLAVIVSVDKQAVEAAIEETLPVTSEMGWRITVAQSLPKGDKLETVIQKGTEAGAAAFLPFVSKRTVVQYDERKEAKRIDRWRKIAKEAAEQSHRSVVPEIHPVCSWKQLIKQLSGYDLVLLCYEEEGRRGAGLREVLGSFRSELSGKSDPSILVVIGPEGGFAPEEAEEAAAAGARTVGLGRRILRTETAALFALACLAYEAGELGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP39</accession>
    <name>A0A398CP39_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04275">
        <property type="protein sequence ID" value="RIE04275"/>
        <property type="gene ID" value="D3H35_06585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040591">
        <property type="entry name" value="YlmH_RBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17774">
        <property type="entry name" value="YlmH_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="1">
        <location>
            <begin position="185"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="261" mass="29334" checksum="0B6681432A75E01C" modified="2018-12-05" version="1">MSHREIYEHFHPDEKSFVDRAWEWVERAAERHETRRTDFLDPRQAFILFTLANRHPDAAVRLDGGGSAAERKRAIIAPDYKPLEDEEMGIAVLRISSDDKKIAELDHGDYLGALLGLGIKRDKIGDLHVHEDGCDALIAEEIADFLIGHMKQAHRVDVTVSLLPLEELRESETELQESTLSVASLRLDGIASDVFRLSRAKILAPIKAGRCRVNWKSEEDPSASLRAGDVVSMKGFGRFKVIEVEGMSKSGRIRVRIGKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP55</accession>
    <name>A0A398CP55_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_06695</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04295">
        <property type="protein sequence ID" value="RIE04295"/>
        <property type="gene ID" value="D3H35_06695"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="334"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="155"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="270"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE04295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="454" mass="50151" checksum="7FDD4FD16E0ACF7B" modified="2018-12-05" version="1">MKVLIVGSGYVGLTTGSALAYLGYEVTLLDINKERILQLRDGEVPIHERGLSEVIKESKHNMKFISEWESFDSNVDVVIIAVGTPNKGNGDVDLSYVEIVAKSIGEKLTVESEPIIINKSTVPIGSARRVKTIIEEELKKRNIFKSIDVASNPEFLREGEALFDTFYPDRIVIGVETEKAKNRLLKLYQPLLEQTFTPPLSIKRPEGISLPSVITTSPTSAELIKYAANSFLAMKISFINEFAGLAELVGADIKEVAKGIGLDKRIGDRFLQAGIGWGGSCFGKDTAAILFTANQYNYDMQLIQATINTNYKQREAIIRILQSELKVLRGSTIGLLGLAFKPNTDDLRDAPSIDIIRSLIELGANVKVFDPIAMDNCSIQNPELNVSYCNSADELFDGCNGVVLVTEWEEFLHLPYSKLANNMKNKVIVDGRNVLDKENLKKSGIIYRGIGRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPA4</accession>
    <name>A0A398CPA4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adenosylhomocysteine nucleosidase</fullName>
            <ecNumber evidence="2">3.2.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_07090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.9" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04355">
        <property type="protein sequence ID" value="RIE04355"/>
        <property type="gene ID" value="D3H35_07090"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008782">
        <property type="term" value="F:adenosylhomocysteine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008930">
        <property type="term" value="F:methylthioadenosine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010049">
        <property type="entry name" value="MTA_SAH_Nsdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01704">
        <property type="entry name" value="MTA/SAH-Nsdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="6">
        <location>
            <begin position="5"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="233" mass="25063" checksum="6E02E181C34FC9CC" modified="2018-12-05" version="1">MTYGTIGLIGAMQEEIELLLGQLQNAETERHAGITYYKGTLHGRKTVLCKSGVGKVNAAVCTQALIDRFGADAVIFTGVAGAVDPKLNIGDIVISTSSVQHDMDVTPLGFTRGVIPYQEVSDFPADERLISLAQEAGEIALPGRCHTGKVLSGDQFVADREFVKKLREELDGACTEMEGAAVAQVCFMNDVPHVIIRSMSDKADGSAHVNFAEFTVEAANRSFSIVNEMVRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPB6</accession>
    <name>A0A398CPB6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04423">
        <property type="protein sequence ID" value="RIE04423"/>
        <property type="gene ID" value="D3H35_07515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="414"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="606" mass="68391" checksum="C881007E8CC192A9" modified="2018-12-05" version="1">MAVNVHRLARAGGAGGGRLQLRSGPVRVFGDKVLKWHSYDMVNNPRVAKIGYLDQYHDRYNSYIIGGSKSSSISPTLLNKYYGDDAKFYSMLMYGGDFHDYEKTLVYIVDHYKPKNIVIHMSLQEISHYNETATDFKQSLHAKVTGESLFSFYLKYLKLNPSYGYTKLEGLAKRGIDPFEYSQFIPETGVYNKVKRDAEKVDDLEAFMAANKEAFAPFGKLEATALDKNVEAIKRMKEYTESHGITFRMIAGATSEQELKSYDMSALKRYWAKIANVTDFWDFSGYTNVSGDLRYFYDTMHYRNTLGAMMLGYIFKDPDVYVPKNFGHLTTKDNVAEYAEKIFTPPAAASKTKLKMPILVYHHIDEDPDEPGPLITPPDKFRSDMAAVKAAGYTPVFMQDLIDYVDGKKELPAKPVAITLDDGYLSNYEYAYPILKELGMKATISMIGWSVGLTEHRVPGKPFYPHFTWQEAKEMVDSGVIDIQNHSVDMHESGKDDPDVRIGVLSKDGESTGAYGQAFIEDVREMESRIESRLGNEVNVFTYPFGYYNHLSEQILKDMGYRVTLTTKSGISDIVRGDPRTLFGLKRINAGPEVSSDALVGKLAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPE5</accession>
    <name>A0A398CPE5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03189">
        <property type="protein sequence ID" value="RIE03189"/>
        <property type="gene ID" value="D3H35_18730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="SSF50985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="211" mass="21627" checksum="ABDA5CD8D12F64EE" modified="2018-12-05" version="1">MPFRCSGRGRERMDMGAQRLRSARGRHEDEPFRSCEGGGHRGVTAIASGDYRTLALTSDGSVWNWGSNEAGQLGDGTAVQSSAVPVKVSGFGSGRKAIAIAGGNGPFVALASDGTVWTWGYNAFGQLGDGTKDNRSQPVQAILPGSGKAIAVAAGTGHTAILEDDGTVWAWGSNSVGQLGDDSAAERLSPAKVAGISEVGSISAGYYHTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPG3</accession>
    <name>A0A398CPG3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_19830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03209">
        <property type="protein sequence ID" value="RIE03209"/>
        <property type="gene ID" value="D3H35_19830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="46"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="348"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="382"/>
            <end position="389"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="585" mass="65545" checksum="42DC654130F8DCE2" modified="2018-12-05" version="1">MEHLFENEALTDRRPSRFLLLLYRKHWSKLLLSIVFFLLKHSPVYVIPIITANLINLAMHPEKNSTSTLWLNIIVLAFVIVQNIPTQVLHISYLSKAVRYMEAELRSTLVRKLQRLSMSAHGELMSGKLQAKVLRDVEAIEFLSRQMMLSVVPAIINVIVAVAITSSRSLLVTGFFVLTIPAALAIVSFFRNKIKASNSEFRKQIESMSGQVSEMVGMIPITRAHGLEQTEINKIDKTLTKLRHKGYKLDIVEAYFGSYAWVTFQLFQVLCLAFTIMLAYKGTIPIGDVVLYQSFFTMILGSITQLLNVYPNIAKGFESIYSVTEILLSKDTEAYQGKKKPEALKGQFTFENVSFGYPNSERHVLQQFNINVKAGESIALVGASGAGKSTVLNLVIGFSKPGEGRVLLDGVPMDELDMGAYRSSLAVVPQTTLLFSGSIRENITYGLPSVSDEKLAEIIRMTHLEDVIAQLPDGLDTMIGEHGGRLSGGQRQRIAIARALIRDPKIILLDEATSALDNESEYRVQQAMRKLTQGRTTFIVAHRLSTIRDADRIVVMKQGRCVEMGTFEELMELRGEFYQLKQLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPH8</accession>
    <name>A0A398CPH8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Photosystem reaction center subunit H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_21030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03229">
        <property type="protein sequence ID" value="RIE03229"/>
        <property type="gene ID" value="D3H35_21030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="77"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="166" mass="18476" checksum="E32D84075FA76C87" modified="2018-12-05" version="1">MSGRSSGKVKDVWFDEFWRLSGVVLDTRVWLSKAVKAIKWDNIVSCGEDALLIRDSGAVETIDRNQLLRTFNGGVVRLKEMPVYTVAGIELGKVADVYFKDSEGTPLVGYELTDGFLADVFEGRRRLYLPDGPENVILGEDAILVPASCERVLERDHTRKVIGEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPL3</accession>
    <name>A0A398CPL3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04465">
        <property type="protein sequence ID" value="RIE04465"/>
        <property type="gene ID" value="D3H35_07745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="294" mass="32244" checksum="BF0B2F2CFC2EB543" modified="2018-12-05" version="1">MCTTGAVVCRDDRGLPHVYGFKNSDSAPVGYWHGRTGGVEGFASLAYGLFPQLGVNAGMNEKGVALISSFFDYADPENEGADGSRYWSGDLRGKAQGEALAKARTASEALAVMNDVFERERELSIGGCHIIADPEGSLFVFEHSRGRVAVQDATNQRWVARSNQAFCLFREEQRTMSEDIAQDRNERLQSAEDTLRFLTERDIQPPDARKALRQLLSSHAYVDSQSHCDNGMAAADPVNRQGSICAHGIVRGRSNAAIPHVTMSGMIWELSAGTMSYTLGQPCRSAWRKLSFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPN9</accession>
    <name>A0A398CPN9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small, acid-soluble spore protein I</fullName>
            <shortName evidence="1">SASP I</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">sspI</name>
        <name evidence="2" type="ORF">D3H35_18760</name>
        <name evidence="3" type="ORF">D3H35_18855</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Spore core</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="1">Expressed only in the forespore compartment of sporulating cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SspI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02698">
        <property type="protein sequence ID" value="RIE02698"/>
        <property type="gene ID" value="D3H35_18760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02711">
        <property type="protein sequence ID" value="RIE02711"/>
        <property type="gene ID" value="D3H35_18855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030436">
        <property type="term" value="P:asexual sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00669">
        <property type="entry name" value="SspI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017525">
        <property type="entry name" value="SspI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14098">
        <property type="entry name" value="SSPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03092">
        <property type="entry name" value="SASP_sspI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="80" mass="8890" checksum="C9040A53DF4064C7" modified="2018-12-05" version="1">MQLNLRQAIIQRVHDKTNEELRDVVDDSVGNAEVTLPGLGVLFEIIWTGSTEEERLKMIGTLHDHLHNESTEAPAVSSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPV9</accession>
    <name>A0A398CPV9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02778">
        <property type="protein sequence ID" value="RIE02778"/>
        <property type="gene ID" value="D3H35_19265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="397" mass="43969" checksum="BFA0D0054073506A" modified="2018-12-05" version="1">MSSIPKIVILGAGYGGVLTSLRLQKELNYNEADVTLVNKHDYHYITTHLHMPAAGTDNPENARVNISKLIDEFKIDFVKSTVVQIRPQDRKVILEDGTLSYDYLVIGLGGEPETFGIPGLLENAMNIRSINSVRLIREHIEYQFARFKREPHRTDYLTFVVGGAGFTGIEFIGELSDRIPELCKQFDVDPSLVKIYNIEAAPTALPGFDPELVEYAMEVLRKKGVTFRIGTAIKECTPDGVIVGDGEEIRSQTVIWTGGIRGNRLIEEAGFETMRGRVKVDEFMRAPGHENIYILGDNSLVFNPEGRPYPPTAQIAMQAGVNCAHNLVASIRNQPLKGFAYSNKGTVASLGKGEAIGIAFGKKYKGRVAAWLKKAIDLRYLFIIGGIPLVLRKGKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ36</accession>
    <name>A0A398CQ36_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_05590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04562">
        <property type="protein sequence ID" value="RIE04562"/>
        <property type="gene ID" value="D3H35_05590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018309">
        <property type="entry name" value="Tscrpt_reg_PadR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10400">
        <property type="entry name" value="Vir_act_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Vir_act_alpha_C" evidence="2">
        <location>
            <begin position="93"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="180" mass="20993" checksum="651F83DF47889E7D" modified="2018-12-05" version="1">MVGADVILGLLHKRPFSGYEIKNYFETLFFYFYGTSFGTIYPTLNKLERQGCISKQSVPQDNRPNKNLYSLTDKGREQFRDYMDSPVEADVFRSDFMMRLFFGSLAGPEKILGWMTERLEQTTQTLKKMEEDYNLWSPSMSPSQQICMQWGIESQRTSIHSLRDGIDRLQTTTFSREGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ38</accession>
    <name>A0A398CQ38_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LysR_substrate domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01957">
        <property type="protein sequence ID" value="RIE01957"/>
        <property type="gene ID" value="D3H35_14395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysR_substrate" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="81" mass="8993" checksum="4071CF444ACA1419" modified="2018-12-05" version="1">MEMGSTQSIKETVEAGLGLTLQSNLCLRKELGLGTLKLLDVAGLPVRRNFHILIRVGDLRTRTLDVFLEALRLVTAEMNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQC4</accession>
    <name>A0A398CQC4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04735">
        <property type="protein sequence ID" value="RIE04735"/>
        <property type="gene ID" value="D3H35_04430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="159" mass="19359" checksum="82566EB683A8B182" modified="2018-12-05" version="1">MSFPDGLSYHIRKYKITTLFQRLHNKFAERVGWRPIVEPLHNKFAERVGWRPIVERLHNKFAERVGWRPIVERLHNKFAERVGWRPIVERLHNKFAERVGWRPIVERLHNKFAERVGWRPIVERLHNKFAERVGWRPIVERLHNKFAESVGWRPIVTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQG2</accession>
    <name>A0A398CQG2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04785">
        <property type="protein sequence ID" value="RIE04785"/>
        <property type="gene ID" value="D3H35_04735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="189" mass="21625" checksum="530E6A2B8E0A3275" modified="2018-12-05" version="1">MQRADQYDPLSGLVRVNHMKYGYSYYQDAQQPLLIGGAFNEPDELQHVKIKQPDPAHVNPQSRRIAKSGVQAFVDEHTKGLNVSVSAPIAPRHPHLYHIEKKVTSWLNDTFHGIGAKHLQAYLDEYCFRLNLDFRQIPIVGQLLQWCAITPTLIYDELTRDKPVLAVPWHAWGSKAKWKGNYLSLWNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQK5</accession>
    <name>A0A398CQK5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase</fullName>
            <shortName evidence="8">DHK-MTPene dioxygenase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="8">ARD'</shortName>
            <shortName evidence="8">Fe-ARD</shortName>
            <ecNumber evidence="8">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="8">ARD</shortName>
            <shortName evidence="8">Ni-ARD</shortName>
            <ecNumber evidence="8">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mtnD</name>
        <name evidence="9" type="ORF">D3H35_04655</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 1 Fe(2+) cation per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="8">Binds 1 nickel ion per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="8"/>
    <dbReference type="EC" id="1.13.11.53" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04772">
        <property type="protein sequence ID" value="RIE04772"/>
        <property type="gene ID" value="D3H35_04655"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01682">
        <property type="entry name" value="Salvage_MtnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023956">
        <property type="entry name" value="ARD_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="PTHR23418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="1 8" id="KW-0533">Nickel</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="site" description="May play a role in transmitting local conformational changes" evidence="8">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="site" description="Important to generate the dianion" evidence="8">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="179" mass="20444" checksum="33CA674E8AF33561" modified="2018-12-05" version="1">MAEIRIRNTNERISGEENVGSFLAQQNVLYEHWDASKLPESLRGKYVLTDEEKELILSTYNEEIVEIAGRRGYKTWDIVALSEATPDIEALLKKFEQVHTHTEDEVRYIASGHGIFIIKGDEETGYFDVELEPGDVISVPEGQPHFFTLMEDRQIVAVRLFIEPAGWVASPYEDPAFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQN9</accession>
    <name>A0A398CQN9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03118">
        <property type="protein sequence ID" value="RIE03118"/>
        <property type="gene ID" value="D3H35_13085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="68" mass="7904" checksum="09ACFD3B229CD809" modified="2018-12-05" version="1">MNNRLEEIRKQRGIKQEELAAALEVSRQTIGSLENGRYNPSILLAFKIARFFGMSIEEIFIFEEDENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQU3</accession>
    <name>A0A398CQU3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01304">
        <property type="protein sequence ID" value="RIE01304"/>
        <property type="gene ID" value="D3H35_23255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019069">
        <property type="term" value="P:viral capsid assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009636">
        <property type="entry name" value="SCAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06810">
        <property type="entry name" value="Phage_GP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="52"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="185" mass="20679" checksum="CFD285B27D95F026" modified="2018-12-05" version="1">MIRMEWLKKLLEAQGLSEAQIKTITEGVTTNYTGYVPPYRFEIVNTARKTAARTLKARDKQLEELQKALSNEAALKEQIAQLQADNRSASEKFEADLNDLRLSMALKSSLAGKVHDLDIVAGLLDKNKIELDDVGSVKGGLDDQLEALQVSKAFLFVTDSGVKPRFKSASRRKRRKIGRGKRSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQZ7</accession>
    <name>A0A398CQZ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_23570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01354">
        <property type="protein sequence ID" value="RIE01354"/>
        <property type="gene ID" value="D3H35_23570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005085">
        <property type="entry name" value="CBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031965">
        <property type="entry name" value="CBM26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16738">
        <property type="entry name" value="CBM26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03423">
        <property type="entry name" value="CBM_25"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01066">
        <property type="entry name" value="CBM_25"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017283538" evidence="6">
        <location>
            <begin position="34"/>
            <end position="2102"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="787"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="879"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="1073"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="1267"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="1461"/>
            <end position="1546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="2102" mass="227824" checksum="4DE6A41133DB9401" modified="2018-12-05" version="1">MKLARKTLNAFLICALVLSTFLTFGSARQEVSAAATTSTEPASPFSWDNATVYFEITDRFLDGDSSNNHSYGRELDQSGNEYSGYKNKVGTFHGGDLKGLTNKINEGYFNNLGVNAIWITAPYEQVHGWVGGEAFRHYAYHGYYPLDFTEIDKNMGTESDMKTFVDTAHEHGIRIVMDIVMNHAGYETMKDMSEYDFGQLASGWQSYYYNQPESSAHYTTYNNIVQNTDSSRWSKWWGSDWIRVNKSGYDACGGSDTTMCLSDLPDFKTESSKVVGLPPILLSKWDSAKKTKEQQELDAFFNRTGKPRTVSNYLTKWLTDWVRDYGIDGFRVDTAKHVDQSVWKSLKAEAVTALRDWKAANPSKKMDDLDFWMTGEVYGHGVGRSSYFDNGFDSLINFSFQGQAGNLDKLESIFSEYASKINSDDSFNVLSYMSSHDTSLYNRGNLINGGTSMLLLPGAVQIYYGDETARQPVTAPWDQPTRSDMNWSSINQSVLSHWQKLGKFRSNHISIGAGAHKQLQASSPYVFSRTYNKNGLEDKVVVAVGASGSTQVNVSGVFDDGAAVRDAYTGAETVVSGGKATFTANGNGVILIEELPNPKAKVSATPMGGKFSSATKDITLYVKNSATGKYTLDGSDPQTSGTSFTNGQTLTIGTGMQIGDTATLRLYAVNELGSDSKQYTFTKTDRSMLTVHFKKPSNWSTPQLYFYETTPKVTEPVWASAPSMTDDGDGWYSYTIADVESTRVIFKDASGKQLPAAQSAGFLISAEGWYDGANWIDNPVDNDPPSVPTNLAAAAKTQNSVSLTWSPSTDNVSVKGYEIYRNGTKVGTSTSAAYTDSGLTAETAYTYKVKAYDAAGNKSDESSALSVTTEPKDLQAPSVPTNVQAASKTNNSVSLTWSASTDNVGVTGYEVYRNDVKVGTSASTSYADTGLAADTAYTYKVKAYDAGGNLSALSAPLIVTTEKAPTTNTATIYYKRGYSTPYFHYTPTGGAWTTAPGKAMTASTQYPGYSEITVDIGTATSLKADFNNGSGTWDNNGGKDYAFQQGVWTFENGTIKAGTPTGGVIIDTIAPSIPAGVQSTAKTHNSVNLSWSASTDNVSVTGYEIYRNNSKVGTSAGTTYADSGLAASTEYTYTVKAYDAAGNKSDASAELKVTTNAQPTTNTATIYYKRGYSTPYFHYTPTGGAWTTAPGKAMTASTQYPGYSEITVDIGTATSLKADFNNGSGTWDNNGGKDYTFQQGVWTFENGTIKAGTPTGGVIIDTIAPSIPAGVQSTAKTHNSVNLSWSASTDNVSVTGYEIYRNNSKVGTSAGTTYADSGLAASTEYTYTVKAYDAAGNKSDASAELKVTTNAQPTTNTATIYYKRGYSTPYFHYTPTGGAWTTAPGKAMTASTQYPGYSEITVDIGTATSLKADFNNGSGTWDNNGGKDYTFQQGVWTFENGTIKAGTPTGGVIIDTIAPSIPAGVQSTAKTHNSVNLSWSASTDNVSVTGYEIYRNNSKVGTSAGTTYADSGLAASTEYTYTVKAYDAAGNKSDASAELKVTTNAQPTTNTATIYYKRGYSTPYIHYAPTGGTWTTSPGKAMTNSPDHSGYSVITIDLGTATGMQAVFNNGLNTWDNNSGQNYTFQQGTWTFESGTIKSGVPGNNGGGGDDTPITDPVDWSKQSIYFMMTDRFVNGDTSNDNYGGFNSDKSNPTKWHGGDFQGIINNLDYIKNMGFTAIWITPVTMQKGAYAYHGYHTYDFYSVDGHLGTMDKFKELVNTAHQKGIAVMLDVVVNHTGDFGTGGAAAPFNNYDWYHHIGDISNNDYNTNNTYRIENGEVAGLDDLNQENPAVANALNDWIKWLIAQSKVDGLRVDTAKHVPKWYLKSFDNAANTFTIGEIFHGDPAVVGDYSNYLDAVLDFPMYYTITDVFAKDGSMNLIKDRYNSDNKYRDTRFNGVFIDNHDTKRFLNVATSGDKWKQLKAALGFVLTSRGIPIVYQGTELGYSGGDDPSNREDMVLNANHELYKYIAQVNTIRKAHPALQNGTQTEKWVDNDIYAFQRSKDGDEALVVINNSWSSQTRTISNVSNMGQAYNRMGSDSASVNNGSITVTLAPKEVKIFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRA6</accession>
    <name>A0A398CRA6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05062">
        <property type="protein sequence ID" value="RIE05062"/>
        <property type="gene ID" value="D3H35_02725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="1">
        <location>
            <begin position="23"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="446" mass="49974" checksum="BA08B80562043FAD" modified="2018-12-05" version="1">MVVILAASLFPRQISFGKENGNFKVMGYFTESSYLNDPIDEAVQFDGLTHLIYGFLKPASDGSLYPIGQPERLKELVDKSHAHGVNVVIAVGGVFYGKEPLSGHFEALAGNDEAIQRFVREVWAFVETYKLDGVEIDWEYPDAEASAKYERLLLALKEVLSPMGKTLSAAVAAAGSVNTKAESVQSVTDKALESLNWINIMAYDLAGGQHSPYWLADVSIQYWKKRGAPEDRIVVGIPLYARPSWKQYRNLVALDKANAYLDFVPGDKLDSYYNGLNTIRQKTRLALNKGGGIMFFDIQEDTRDETSGLKAVLDMIQRYEQYNLDDYFIVVDNRELLYAPEEKLGMPYKDGQNRIQIPVRKALEAIGAEIDYDHASRTVTAIREDTTVKIHIGSEVLEVNGNKVTMDTKAAVQDGRTYLPLRWVYESFGYKVIWSESSKTVVASKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRS2</accession>
    <name>A0A398CRS2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05262">
        <property type="protein sequence ID" value="RIE05262"/>
        <property type="gene ID" value="D3H35_01705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="7"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="182" mass="19727" checksum="2CB7F3E4BC3EE593" modified="2018-12-05" version="1">MGNEKLKIGIVLGSTRQGRVSPQVGQWVKQIADQRGDAEYEIVDIAEFKLPFLGEGTGQEPALASWNEKIGSLDGFVFIVAEYNHSITGALKNALDSARDAWNNKAAGIVSYGSTGGARAAEHLRGILGELLIADVRVHPTLSLFTDFENYSTFKPSELHLTNVNAMLDQVVAWSGALKTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS82</accession>
    <name>A0A398CS82_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_13495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01804">
        <property type="protein sequence ID" value="RIE01804"/>
        <property type="gene ID" value="D3H35_13495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032687">
        <property type="entry name" value="AraC-type_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12625">
        <property type="entry name" value="Arabinose_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="235"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="336" mass="37372" checksum="CAAF28809B462ED4" modified="2018-12-05" version="1">MSDIGLSIKLVYPIVKTLSAQGIELARFYSVTGFDERLLQDPEARISELEYDRLLNSAAELTDDESFGVRQGMALEIFDLGILGYVLVHSGTIREALASYQRYNVVLCNGIDVTTKESGEEADILVTFPNPASNPSRHCAEGVASSLFHLFSKLSGRSVPVRAVEFVYPEPGEYGGHASVWGVMPKFGGESNLIRVSREMLDFPIMYADAKLLQAFEEDVKDVRSRLLYGRALSDRLAEWMVSAMASALPSLAEASKRFHVGTRTLQAKLKGEGTTFNEILSRVRMELAIKYLGNRQYSVGDVAYLLHYSEPSAFQNAFKKWKGETAGQYRLRLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSB7</accession>
    <name>A0A398CSB7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_18685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02687">
        <property type="protein sequence ID" value="RIE02687"/>
        <property type="gene ID" value="D3H35_18685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="232" mass="25096" checksum="E1CD6BEB3074B4A7" modified="2018-12-05" version="1">MKQWLSRWNSGESGKVALLFVYLFCVASASTVGRTAADALFLSHFDSGLLSKMYLPQSAALILVGYLFQKFSHRIRIDKLIIGLIPMVTLLVLASRIGVGLEFRWVIPVMYVAYDVFNFLMIVCFWQLASAVLDQRKAKKTIGLVGSGGITGGIVSGFGLKLIVPLVGTANLIYFYAGLQISALVMVLLLTRISDLSAEGAASPGKSAERPLPKQASGSPEPNRGYSPTFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT38</accession>
    <name>A0A398CT38_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_17440</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02481">
        <property type="protein sequence ID" value="RIE02481"/>
        <property type="gene ID" value="D3H35_17440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="162"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="223"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE02481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="442" mass="50194" checksum="6BF62071D2B8E0C7" modified="2018-12-05" version="1">MSFKWKISAMITATVALILIATHIFVYYKIKSVTEERVQIYLLEKGKRLIDRIEANPGALGKEVDEWAEELEIDQAYQIINTNGIVLFETRSVIGQELIGEATSGICAETEVYYPGSTGLTIRLFDRADRELEFLKDLRLWLLAGSAFGTLLASVLSYFISRAAIHPVRKTIHRLKRIDIQQLDQRLEEPQARDEIYHLTQAFNHLLGRLEQGVKQLKQFVADASHELRTPTSIIEGHANLIKRWAKESPEIMEESLGYITQETVRIKTVTDQLIQLALLEQNEPIFRFESPEVNAIVRTIQLRLVPLHRHVDIQVHELQAPVFAHIPQEYFQQVLLNVLNNAIKYTPEGGNIHIHVSKASDQAIVRVKDTGIGIPPEELSRIFDRFYRVDKSRNRAHGGSGLGLAITKKMLEAFGGTISVESQPRRGSVFEIRVPLLSNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTC9</accession>
    <name>A0A398CTC9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_21125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03087">
        <property type="protein sequence ID" value="RIE03087"/>
        <property type="gene ID" value="D3H35_21125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="62" mass="7152" checksum="DF5CA4ACA40D47FA" modified="2018-12-05" version="1">MKKSWRDLTKTDNWKAKTKSASGLTQRIGGKLKGKRFENPVRSVGMKLFLLIFCSIWRASLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTY8</accession>
    <name>A0A398CTY8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GtrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_19285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02781">
        <property type="protein sequence ID" value="RIE02781"/>
        <property type="gene ID" value="D3H35_19285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="13"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="140" mass="15631" checksum="7BCB7B1AD6B724CA" modified="2018-12-05" version="1">MRLRSEESRKLVKYALVGGMNSGVDFAVFVSLVYAAGMTSLWAQVLSYTAGLLNSYFWNRRWTFGVKRKQTVGEMVRFIVVNGLSFGVATAVLLLLEHWGFGSIFAKIVSFVFGLVVNYAGYRAWVFRGHTPQPETHPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU14</accession>
    <name>A0A398CU14_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Aminopyrimidine aminohydrolase</fullName>
            <ecNumber evidence="6 8">3.5.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">tenA</name>
        <name evidence="11" type="ORF">D3H35_17270</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4-amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>4-amino-5-aminomethyl-2-methylpyrimidine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:31799"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:63416"/>
            <dbReference type="EC" id="3.5.99.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H2O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17509"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="EC" id="3.5.99.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the TenA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.2" evidence="6 8"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02454">
        <property type="protein sequence ID" value="RIE02454"/>
        <property type="gene ID" value="D3H35_17270"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050334">
        <property type="term" value="F:thiaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026285">
        <property type="entry name" value="TenA_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027574">
        <property type="entry name" value="Thiaminase_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003170">
        <property type="entry name" value="Pet18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04306">
        <property type="entry name" value="salvage_TenA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0784">Thiamine biosynthesis</keyword>
    <feature type="domain" description="TENA_THI-4" evidence="10">
        <location>
            <begin position="11"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR003170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR003170-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE02454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="223" mass="26181" checksum="6F73DD5FB9D4751C" modified="2018-12-05" version="1">MSRFSERLYRAAQEIWIKSHRHPFLTELREGTLDPGRFIYYLKQDYVYLIDYAKMFAIGSIKARDLETMVKFAELLHSTLNVEMELHRQYAERFGVTREQLEQTRPSPTTVAYTKYMLDAAAQGSLAEVVAVLLPCMWSYREIGTAFMKFPGALDHPLYREWILMYGSEEFGALADWCIGLMDRLAEGLPEQELAQLEERFVAASKLEYLFWDMAYRQEEWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVA3</accession>
    <name>A0A398CVA3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphonate C-P lyase system protein PhnH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">phnH</name>
        <name evidence="1" type="ORF">D3H35_01480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05219">
        <property type="protein sequence ID" value="RIE05219"/>
        <property type="gene ID" value="D3H35_01480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019634">
        <property type="term" value="P:organic phosphonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038058">
        <property type="entry name" value="PhnH-like_sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008772">
        <property type="entry name" value="Phosphonate_metab_PhnH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05845">
        <property type="entry name" value="PhnH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020680">
        <property type="entry name" value="PhnH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159709">
        <property type="entry name" value="SSF159709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03292">
        <property type="entry name" value="PhnH_redo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="196" mass="21587" checksum="C2F00C32D6C349FB" modified="2018-12-05" version="1">MIDRIHDIQSAYRKLVDSLSRPGLVSDLSPEAGKLPGNDDCLPATKILALMLLDTEVRFKVFSEREAEVAHGFAQLTYAKNTEASEADFLFVLNDAKPGELRRALSEASAGDLQNPNRSATIIVETRGISGEAGLRLTGPGIETEAFADVRTVDEWVELRAERNEEFPLGVDLIFVDADHRLLALPRTTRATREVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVC4</accession>
    <name>A0A398CVC4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_01635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05249">
        <property type="protein sequence ID" value="RIE05249"/>
        <property type="gene ID" value="D3H35_01635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="421" mass="45008" checksum="EE90208B89CE605F" modified="2018-12-05" version="1">MKTFIYFYRTFLSTGIQTVLPQLFIMAYVPLHRSELLPLCLLLASISSIGGIAASRHLSRYFYGGPVDGRAAIGIGLSALVGAGVISMFLTHDWPIYFIAVALVSGLLELLFNMLDHRYVEELSGIEFKAHASRVTVVQLIALTAAPFYFTFTVDMVWLQVLLAAGGSAMLVALMLSSASAAKQGQTVLAMDTADRPARAASGANRLRTRDFAFLLYALAVYVAVFIFSSHLIYILHDYYGMTGATWKGGLLLGIGNLVAVAVVLGCFRVKSAQMVRKSHAKAVVSSTALPARTHAAVVACLLASAVLLYGRWLTGFAFILALACLVGGAFGIFQLLAREYASRRAVGEGAGIVLTSYNNLKNIASLVGFSSALALASASSRLHIEYVRLVILAVIVCILAACMALAVIPALGIPQEEEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVE6</accession>
    <name>A0A398CVE6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_06795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04488">
        <property type="protein sequence ID" value="RIE04488"/>
        <property type="gene ID" value="D3H35_06795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="2">
        <location>
            <begin position="59"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="209" mass="24440" checksum="5D33B6DFAE7997BA" modified="2018-12-05" version="1">MESGGRRMSEQILQSILGELKGVNQRLDGMDQRLDGMDQRLDGIDQRLDRMDQRFDGIDQRLDGMDQRLDGIDQRLDRMDQRFDGIDQRLDGMDQRFDGIDQRLDRMDQRFDGMDQRLDRMDQRFDGIDQRLDGVDQRFDKIETTLGEIKLAVLETHEFVGRIAVVQEQQAAAIDSLKTEQHRHGRILEALAVKSLEHDTEIRELRRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVS8</accession>
    <name>A0A398CVS8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_00590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000006">
        <property type="protein sequence ID" value="RIE05419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05419">
        <property type="protein sequence ID" value="RIE05419"/>
        <property type="gene ID" value="D3H35_00590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041380">
        <property type="entry name" value="Acetyltransf_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025559">
        <property type="entry name" value="Eis_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17668">
        <property type="entry name" value="Acetyltransf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13530">
        <property type="entry name" value="SCP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyltransf_17" evidence="4">
        <location>
            <begin position="9"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="SCP2_2" evidence="3">
        <location>
            <begin position="113"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="195" mass="22395" checksum="840C0EDF3FBFEC15" modified="2018-12-05" version="1">MRCKYSCTLARTDDWWERKVLSKPGVAALYRNPDGIAEGYLLYEAADRKMRIHEWVHTTETARAALWSFIGNHDSMIDQLVMMARRTMTCLSCCRSRGSSKSCCLISCRIVDVERFIEPYSFAASEREDVLAIRVEDERADWNDGWFRLTIPANGRSALVERTEMAAPGIPRLRATFRHGLQCSPEDDVRQRSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVV6</accession>
    <name>A0A398CVV6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03154">
        <property type="protein sequence ID" value="RIE03154"/>
        <property type="gene ID" value="D3H35_16345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="108" mass="12150" checksum="C47FDFE2732FF940" modified="2018-12-05" version="1">MASDTLEELGYDPQLHEGGRLHIHVHKEDLTSALEVVQSHGGQLMEHAPAETVTITNLAYGIDDIPIPAHTVNEDWEDRYRERSSLPRSGEEEAFIPDDGSYDHFDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW23</accession>
    <name>A0A398CW23_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2269 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04738">
        <property type="protein sequence ID" value="RIE04738"/>
        <property type="gene ID" value="D3H35_04445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018729">
        <property type="entry name" value="DUF2269_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10027">
        <property type="entry name" value="DUF2269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="152" mass="16531" checksum="A5C45A8EF5B43254" modified="2018-12-05" version="1">MEWLVAVHVISAIVGIGPTYFGHVLFRKRQRMEQLRQSLALFDLLNYFPKIGGSIAVVSGVALVGFSGWEFADLWIWISLVLYVLIQIVAVGILGPVVGQLIHALNGGDEQEAGSAAVTNKAAFLLAKANRLFNIVSFLGLVLIVLMIVKPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX65</accession>
    <name>A0A398CX65_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03801">
        <property type="protein sequence ID" value="RIE03801"/>
        <property type="gene ID" value="D3H35_09615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="312" mass="34545" checksum="8C235B48E4B2EB26" modified="2018-12-05" version="1">MSNISVIVPTYRRPADLLRCLNGIDGQELAPHDVVVIYRDTDDDSIRVIREWQSVPGKYGKKSVQVTEPGVLVAMKEGTKAAGGEIVAYTDDDAVPRADWLKRMSAHYADPSVGGVGGRDVQEGVKEGAAGEKVGEVTWYGKLIGNHHIGTGAAREVDVLKGVNMSFRKSLIKFPEGLLGSGAQVHFEVHLCLRVRRFGRKLIYDPAILVDHYPAQRFDTDQRNRVVPEAVRHAAYNMHLGILNWGGAVRAPARIVYSVTVGDRSAPGLARLLIACLRRERDVLQSFVPGQQGQWKSLWFRLRQGPPPRMRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY41</accession>
    <name>A0A398CY41_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000004">
        <property type="protein sequence ID" value="RIE05458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05458">
        <property type="protein sequence ID" value="RIE05458"/>
        <property type="gene ID" value="D3H35_00395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="152" mass="16988" checksum="9C7FD0C689C716AF" modified="2018-12-05" version="1">MRRIEPIQREACGIRETRLYGETGKYRILQFADAAVQGAADLKNRVASSFPIRGLPSLDGAQRPSLEDVFVIGQESVNRGAIPQAICRRGNRREGGRAEQIVFQLSAGYNVIVGDGRTFCSIRLRTPSIASFWTLLTRTGLRGIWYPFLFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY44</accession>
    <name>A0A398CY44_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Germane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_08080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03914">
        <property type="protein sequence ID" value="RIE03914"/>
        <property type="gene ID" value="D3H35_08080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Germane" evidence="2">
        <location>
            <begin position="4"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="138" mass="14962" checksum="417D9C282EAA06F9" modified="2018-12-05" version="1">MGVTLYFSARSAEGEGYFVPVTRLINRQPDRARAALQELIKGPQDLASLNPVLTTDLIVDQLSTVENTVDLSLKDAGWSPQSPVPAEMMQALVLTMTEATGAPQVKLAMNGDDTFVDSDSNSYDHPVTRPTAINSLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYA4</accession>
    <name>A0A398CYA4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Formamidopyrimidine-DNA glycosylase</fullName>
            <ecNumber evidence="5">3.2.2.23</ecNumber>
            <ecNumber evidence="6">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">DNA-(apurinic or apyrimidinic site) lyase MutM</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">mutM</name>
        <name evidence="23" type="ORF">D3H35_04685</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.23" evidence="5"/>
    <dbReference type="EC" id="4.2.99.18" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04777">
        <property type="protein sequence ID" value="RIE04777"/>
        <property type="gene ID" value="D3H35_04685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020629">
        <property type="entry name" value="Formamido-pyr_DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00577">
        <property type="entry name" value="fpg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="17 23" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="11 23" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="22">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="21">
        <location>
            <begin position="236"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00016240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RIE04777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="272" mass="30797" checksum="486177C4EC0BA194" modified="2018-12-05" version="1">MPEWPEMETYRTLLSPLVCGRTIQNVEISREKTINMPENEFRDSILGKKILFVERRGKQLLFHLDDGYRLMLHLMLGGYVNYGEQGAKTDDHYQVIIGLDDGNRLFFGGLRLGYLHRVSAKAVIEQLRDLGPDPFDPRLTLEAFRKKLGTRRGKLKPVLTDQKFLSGIGNCYSDEIAFDARIHPETTIASLDENASARLYQSMRSVLEEAASAGGYMEIPLTADDELTGGYNDQCKVYDRGGEPCVRCGTPIVLETLSSRKMFYCPECQRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZF8</accession>
    <name>A0A398CZF8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Segregation and condensation protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">scpA</name>
        <name evidence="5" type="ORF">D3H35_03655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ScpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04601">
        <property type="protein sequence ID" value="RIE04601"/>
        <property type="gene ID" value="D3H35_03655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01805">
        <property type="entry name" value="ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="264" mass="30655" checksum="D6AA0B475D887FF8" modified="2018-12-05" version="1">MKVLYKLETFEGPLDLLLHLIDKAEIDIQDISINEITDQYMAYLGAMQELELDITSEFLVMAATLLSMKSRQLLPKPPATDEPWLTMDDDDGLDPREELIRKLIEYRKIKSVATQLRDHEWERSQVFTREPVDLSPFAVRKPTNPVEGLHVDDLVRAFQKALRRAAGRNRISTIRRDEISVKDRIRDVVETLKLRAKDGKMLFSQLLGDETDRQEIVVTFLALLELMKRRWVTCNQNTIRDEIVVSWTGREEDENGLLDAEISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZL6</accession>
    <name>A0A398CZL6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndk</name>
        <name evidence="4" type="ORF">D3H35_03940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04651">
        <property type="protein sequence ID" value="RIE04651"/>
        <property type="gene ID" value="D3H35_03940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="147" mass="16583" checksum="5A5A181339ADD2FC" modified="2018-12-05" version="1">MERTYLMIKPDGVQRGLIGEIIGRFERKGLKLVGAKLIQMPLELAERHYAEHKGKDFYARLLEFITAGPVMAMVWEGDQAVSHARALIGKTNSLEAAPGTIRSDYAIHTNFNLIHGSDSHESALREIGIFFRDDELVSYEKAVQVWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0M9</accession>
    <name>A0A398D0M9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma-W factor RsiW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_02665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-associated anti-sigma factor (ZAS) superfamily. Anti-sigma-W factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05051">
        <property type="protein sequence ID" value="RIE05051"/>
        <property type="gene ID" value="D3H35_02665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007607">
        <property type="entry name" value="BacA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04519">
        <property type="entry name" value="Bactofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="4">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="204" mass="22426" checksum="F79DC3D522F7AF69" modified="2018-12-05" version="1">MKCNVAVAYIHEYLDGDLPRGQVDDLQKHLAHCSSCETRLSQLERVDAFARAMPAPATPPNMAEQIMKSLPKSRRSPSTWTKWVRRHPAASAAAMFLVVMLSSFVAMWNQDQKLSISGPDLEHVIIEGHTVTVPEGQKVTGDLTIVNGSARVLGDLQGDLTVIDGNVTLASTAHIAGQVKEIDRAVDWLWYKVTSWFGTLAYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0X7</accession>
    <name>A0A398D0X7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_04980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04824">
        <property type="protein sequence ID" value="RIE04824"/>
        <property type="gene ID" value="D3H35_04980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="160"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="386" mass="42620" checksum="CDD1297C05FC53E2" modified="2018-12-05" version="1">MKSRLNIRTIVFISALLLLLTALNVYIGWHGSVLLGTVVPAFPQAVYWPVFLLFSFGYLFGRLVPLPKPLKPTGRLLKVLGSYYIGILEMSVILLPLVDIAAWIGWANGADKDTFVSWAGGIVVGLLTIFLLVGSRNAWSTVTRTFDVRVDKKAGAIEKIRIAAASDLHLGNVVGNRHLGRLVERINAMEPDVILLPGDVLDDAIEPFVRNDMASVLGKLKARFGVYAVLGNHEYFGGDIEEYVKRMSDVGITVLRDEKAIVADSFVVAGRKDRSAEQMDSSGRLETRDLLADVESAMPIILMDHQPYQFDLAEAAGADVLLCGHTHRGQFAPNHWVTKRLFELDWGYLRKGALHVIVSSGYGTWGPPLRIASRSEVIRVNVEFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CAQ1</accession>
    <name>A0A398CAQ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00216">
        <property type="protein sequence ID" value="RIE00216"/>
        <property type="gene ID" value="D3H35_29725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="310" mass="35121" checksum="C067F95A62147062" modified="2018-12-05" version="1">MKRGEAAEDFPPLSPKACILSSRSGSRMNSTELGHRLIRHYPFASESLLNERGIGIYVPPSYYRDENKRYPVLYMHDGQGVFGPNPFSNSSWNVHRTAEELISEGLMEEIIIVGIDNYGQERLNEFAHPLQSSGIPGAPDIICKGESYERFLIEELKPTIDGLFRTLPDREHTALMGSSMGGLVTYNIGFRNPHIFSKLAVMSPYFVRLDLNTLREIPFYKRYPGVNNLALWLDIGEIEANILVEHVRGVVEELIEQGFVFGQNLMYYEVPALRIPRRIGQPECDRRCCFSSGSRAKQLKPSCTAEKKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBU6</accession>
    <name>A0A398CBU6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_29910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00250">
        <property type="protein sequence ID" value="RIE00250"/>
        <property type="gene ID" value="D3H35_29910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="216" mass="24155" checksum="0F768498940BD344" modified="2018-12-05" version="1">MTESDLTSNFPQQSGLPGEKRTDELGMRILKAAQTMFVRDGVDAVSMHKVAKTVGIGQGTLYRRYPNKGSLCMSLMQTKFDCFAEAINEYLRDAANATVFERLSRVVSSLIRFSENDLDWLKAILQSGTLKDAKANIFESPPFLFIRDTVQRLLEEAAAKRELVPLDPAFASVLITSSMTPELMFYLFDSGYTPERIAERYVETFLAPLFAGAGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDZ9</accession>
    <name>A0A398CDZ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF348 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_23850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01406">
        <property type="protein sequence ID" value="RIE01406"/>
        <property type="gene ID" value="D3H35_23850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010611">
        <property type="entry name" value="3D_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007137">
        <property type="entry name" value="DUF348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06725">
        <property type="entry name" value="3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03990">
        <property type="entry name" value="DUF348"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51109">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="G5" evidence="3">
        <location>
            <begin position="165"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="384" mass="41423" checksum="16512EE606539BED" modified="2018-12-05" version="1">MGVVPVQETHDPRPTTRLFAAKWRHEHLRMILIGAILSFAMITMFISLLQDASAKSVTIVDGSSSSVIQTLKDDVTGLLKEQNIVVGPFDSVSMPLTASLEQGSTVVIDRAVGITLQADGKEAATHTTADTVGEALAAMNVTVQADDRVIPSPEEQLQDGMKVTVVRVRSEVVETKHPIAYTVVNKKDDNLESGKQKVVTTGKEGVLVKKTERVFEDGKLVSERIVGNAVSQPAVQQVVAIGTKKKAKVVTLAYEDPKKDENRTLKLNGKTVKVRRLLNNVTLTAYSAGLESTGKSKGDSGYGITASGTTVSEGRTIAVDPKVIPMGWWVYIDGVGFRRAEDTGSAVKGKKIDVYYDNEKHANRFGTKKGYTVYVIGPVKPSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE02</accession>
    <name>A0A398CE02_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_26165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000047">
        <property type="protein sequence ID" value="RIE00860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00860">
        <property type="protein sequence ID" value="RIE00860"/>
        <property type="gene ID" value="D3H35_26165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="SSF89562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="57" mass="6194" checksum="5BB29EEE4BAA71DE" modified="2018-12-05" version="1">MEAERTVGRAALDGIEGARRARAIVDGLIRDTKKILELGFPVFAQARSRSIPKAEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE90</accession>
    <name>A0A398CE90_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_30130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000064">
        <property type="protein sequence ID" value="RIE00172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00172">
        <property type="protein sequence ID" value="RIE00172"/>
        <property type="gene ID" value="D3H35_30130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="74" mass="8697" checksum="7A645CAE484A5DAF" modified="2018-12-05" version="1">MRILVAEDNKINQKFIEFILKKLGYEIDMVHNGIEVLKLMETNTYDVILMDVQMPEMDGFEATSIIKSRPEHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEI9</accession>
    <name>A0A398CEI9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7 8">Elongation factor Tu</fullName>
            <shortName evidence="7">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">tuf</name>
        <name evidence="10" type="ORF">D3H35_30075</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00272">
        <property type="protein sequence ID" value="RIE00272"/>
        <property type="gene ID" value="D3H35_30075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE00272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="377" mass="41583" checksum="50B6B5F69B891E8F" modified="2018-12-05" version="1">MAKAKFERNKPHVNIGTIGHVDHGKTTLTAAITTVLSKKYGGAAVAFDQIDKAPEERERGITISTAHVEYETPNRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLSKQVGVPYIVVFLNKCDMVEDEELLELVEMEVRDLLNEYEFPGDDTPIIRGAAREALQNPDGPWADKIIELFEQVDTYIPQPERDVAKPFLMPVEDVFTITGRGTVATGRVERGTIKIGDEIEIIGLVEESRKSVVTGVEMFRKLLDSAQAGDNIGALLRGVDRKDIERGQVLAKPGSVKPHTEFTAQIYVLTQSEGGRHKPFFTGYRPQFYFRTTDVTGIIDLQEGTEMVMPGDNITVTVKLIAPIAVEENCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEJ0</accession>
    <name>A0A398CEJ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_24890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01586">
        <property type="protein sequence ID" value="RIE01586"/>
        <property type="gene ID" value="D3H35_24890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="284" mass="32004" checksum="CE170BA1A1813F7A" modified="2018-12-05" version="1">MLAIDVRNLNKTYQGFQLKDISFQLEKGYIMGFIGANGAGKTTTIKSILKMIHIDSGEVRILGKNIAEHEIELKQEIGCAFGGIDFYTRSKMKTLTDVIKKFYKNWDDGAYYSYLKRFKLDENKKIAELSTGMKVKYGLALALSHGAKLLILDEPTSGLDPVARDDLLDLFQELVADGEISILFSTHITSDLEKCADFITYIENGKIINSSEKHEFMESYRLLNGSVSQLDQVKERLISYKVNSFGFTGLIHSKDFIPSSDIKATTPSLEDIMIYFAKKEDTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFE4</accession>
    <name>A0A398CFE4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01135">
        <property type="protein sequence ID" value="RIE01135"/>
        <property type="gene ID" value="D3H35_22240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="73" mass="8921" checksum="ED893109589FCFC9" modified="2018-12-05" version="1">MLLLFASWIMAEWRHWRKRSRRTRIWSLIFAVPSVYLSILFIGHPRWPGYGELLEWVYGAPSDWVVYWFESFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFX6</accession>
    <name>A0A398CFX6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copper amine oxidase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_15160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02096">
        <property type="protein sequence ID" value="RIE02096"/>
        <property type="gene ID" value="D3H35_15160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017187161" evidence="1">
        <location>
            <begin position="28"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="2">
        <location>
            <begin position="194"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="294" mass="32145" checksum="CF5FEC3560DD5D82" modified="2018-12-05" version="1">MKMAGWKSALAALVLCFAITGSTSAFAEEADGSGGEGDEAVEQTAESFFEGLEEMEYNELTFQVIRTDVVKGNDKIPEAHFRSIVLFQNTSPYTIQTPATAFELFDKGFNQVALTNVRFEGVKLLPGDSKWIATEYESLAEVTEGQSTKGLKAGMYNSLYGERVEDSSEITAKGVYVFVNSKPLKVKVADPLGTQYVPAKNLLEAMGYKFVWNAKTSTFTATKGQLKVEQKIGSRQMKINGKIVKVDAGATAFVNKAPMISLYLVPTISSTWTVSRGIHDDITILSIVDRTLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG15</accession>
    <name>A0A398CG15_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleoid occlusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">noc</name>
        <name evidence="8" type="ORF">D3H35_24045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01440">
        <property type="protein sequence ID" value="RIE01440"/>
        <property type="gene ID" value="D3H35_24045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023705">
        <property type="entry name" value="Nucleoid_occlusion_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04285">
        <property type="entry name" value="nucleoid_noc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="ParB" evidence="7">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="270" mass="30720" checksum="C5A8599681C1ED56" modified="2018-12-05" version="1">MKEPFSRLLGLSDRSNHEEVKQLPVRDIVPSPYQPRTVFDDDRIDELCQTIKTHGIIQPIVVRLRGGKHEIIAGERRFRAVSKLGMDTIPAIVREINDSQAASMALIENLQRENLTALEEAIAYQKLMDLHQLTQESLAQRLGKSQSTIANKIRLLQLGEQAKSALLERKITERHGRALLGLPTEELQNKLLTEIIEKELNVKQTEMRVAFYLEVAKPVKKRVSFTKDVRLALNTIRQSVDMVNGSGIPIKASERDCEDHIEIVIRIPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG67</accession>
    <name>A0A398CG67_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">panB</name>
        <name evidence="11" type="ORF">D3H35_13010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01723">
        <property type="protein sequence ID" value="RIE01723"/>
        <property type="gene ID" value="D3H35_13010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="9">
        <location>
            <begin position="44"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE01723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="274" mass="30711" checksum="9CFA824E0674F586" modified="2018-12-05" version="1">MKKTMAHLHDKKRSGQKIVMLTCYDYRTAVLQEKAGVDVIFVGDSVGTNVLGYGSETEVSLDEMLYHLKMVKRGVNEAYLLVDMPYRTYEEPQIALETARALLAQGADGVKLEGIEPSIIEFLRGHGIEAWGHIGYNPQLHRDVAVQGKTFEQAAALIEGALELQRAGASMLVLELVPEELADVITNRLSIPTIGIAAGRYTDGQVLSVNDMLGVNPQKLRHAKLYMDFSGQALEAIRSYSEEVRNREFPAESHVRHMKESELRRVEEWLRFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGJ1</accession>
    <name>A0A398CGJ1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FMN dependent NADH:quinone oxidoreductase</fullName>
            <ecNumber evidence="6">1.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Azo-dye reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azo compound oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azoreductase</fullName>
            <ecNumber evidence="6">1.7.1.17</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">azoR</name>
        <name evidence="8" type="ORF">D3H35_24830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 a quinone + H(+) + NADH = 2 a 1,4-benzosemiquinone + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:65952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:134225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:55872"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15783"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:71579"/>
            <dbReference type="EC" id="1.7.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:55874"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="6">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the azoreductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.-" evidence="6"/>
    <dbReference type="EC" id="1.7.1.17" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01575">
        <property type="protein sequence ID" value="RIE01575"/>
        <property type="gene ID" value="D3H35_24830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01216">
        <property type="entry name" value="Azoreductase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023048">
        <property type="entry name" value="NADH:quinone_OxRdtase_FMN_depd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 6" id="KW-0288">FMN</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="7">
        <location>
            <begin position="3"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="17"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="102"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="210" mass="23256" checksum="6BBE063ACA9EB8B8" modified="2018-12-05" version="1">METVLYITAHPLDPQESFSLAVGREFIEAYREANPTDEVVHLDMYKEDIPQFDADVLRGWGKLRSGSSFDQLSDAEKLKVARLEAIVDQYVAADKYVYVSPMWNFSIPPVLKAYTDATSIPGKTFKYTQNGPIGLLSGKKALHIQASGSVYSEGPLAPIEMGYSYLTKVLQFYGIQSIEAIFVEGTASLEQAPAIKEKAIAAAKEFAKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGT5</accession>
    <name>A0A398CGT5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02416">
        <property type="protein sequence ID" value="RIE02416"/>
        <property type="gene ID" value="D3H35_17060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="148"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="255" mass="28799" checksum="94F3675841ED9181" modified="2018-12-05" version="1">MMMILYGAEHHLLVISNTIDAEKHWHSFLQVTISLEDEFEIEVVGQSLSCSGIIINSNVVHRLKGAGHPLMLLLMDSTSEMAASFKRYIEDRKYYAFPPGMMKTIREFVQKEYPGVKDTDSYLSFLGQLMKLLDVEHVNTTIVDPRVREFIQLIKDCTDSEHSVSLYARQMGLSNSRLSHLFKENTGISLSGYMLLHKLQKATYFIFNGLSITDAAMAAGFDSPSHLAVTSKRLLGMTAKDIRKDSVFLKVSCLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH39</accession>
    <name>A0A398CH39_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphotriesterase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_28725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00399">
        <property type="protein sequence ID" value="RIE00399"/>
        <property type="gene ID" value="D3H35_28725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009056">
        <property type="term" value="P:catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PTHR10819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016839">
        <property type="entry name" value="PhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1 2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="283" mass="31699" checksum="03C1ADA5C87397D3" modified="2018-12-05" version="1">MSFVRTVLGDVDSDRLGMVYSHEHLIISGGLGVQKNPDLRLNSVEKACEEVNDVKKHGISTFVDMMPLDCGREPADLMEIASQTGSHIIAATGFHKPMYYSDIHWVHRYNEQQIAELLVAEVEEGMDRHSYSGPVTERLTAKAGLIKGASDYNRIDKLSQKLFHAAAAAQLMTGAPISTHTEHGTCGLEQVELLLGDGVAPSKVIICHLDRNPDFEYHRSVAESGVYLEYDNIGRIKYWPDSVIIDLIEKMIEYGFEDQILLGRTAPFVLISERMEEDRVWPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHB0</accession>
    <name>A0A398CHB0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01860">
        <property type="protein sequence ID" value="RIE01860"/>
        <property type="gene ID" value="D3H35_13815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="198" mass="21324" checksum="55260A2476D63648" modified="2018-12-05" version="1">MQKIDIMRNALKNESDKIVEVQVEYKNGRKKATYCLEPDKVGNREEALARILREVDWEKVEEAEIEYSNGKTAEINLSAVHTARAAALPVVKIEDGEKETEAAAVATEPQANAAVADSKPAEDGVVVSALADSASPAAKAPAPKAASRARNRKPLSARSGRLRTGRAVRKAKAVRSRASKRSVANKFVRAGQRTIVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHF0</accession>
    <name>A0A398CHF0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01910">
        <property type="protein sequence ID" value="RIE01910"/>
        <property type="gene ID" value="D3H35_14110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="250" mass="28635" checksum="2F322A2423646B4F" modified="2018-12-05" version="1">MGKRKRDLRGKSFVWFDLGYTLVYKPRERVYRSFLRENGIDRTEEEVGLAYHLADKYFMRAYPGVLAKEERLYFPWYLGVLNHKLGVEFGLSAQYERLMELQQRERSKWQPYPFSESVLRSLKRGSIGVGLISNWDATARRLLDEHGLAPYFDAIGVSSEVGWTKPEESIFRHSFALAGVAPEECVYVGDNYYDDIVGSARVGMDAILVNRYGRLGIEEIDHEPTVASIESLPEMVLQPHSNNGGDERVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHK1</accession>
    <name>A0A398CHK1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purA</name>
        <name evidence="11" type="ORF">D3H35_24260</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01472">
        <property type="protein sequence ID" value="RIE01472"/>
        <property type="gene ID" value="D3H35_24260"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="298"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="330"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="412"/>
            <end position="414"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE01472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="428" mass="46643" checksum="4595AA138ADC525B" modified="2018-12-05" version="1">MSTVVVVGTQWGDEGKGKITDFLAEKADVVARYQGGNNAGHTILIQNKKYKLTMIPSGIFNENKTCVIGNGMVINPAALVEEIQYIIDNGFSADNLKISDRAHVIMPYHLVLDALEEDRKADNKIGTTRKGIGPCYMDKAARNGIRIADLMVAEEFTEKARRLIVDKNQVITQMYDGEALDAESIISDYLALAEKLRPFVTDTSVVLNDAIDEGQKVLFEGAQGVMLDIDQGTYPFVTSSNPSAGGVCIGSGVGPSKIQQVIGVAKAYTTRVGDGPFPTELLNELGQWIRDKGHEYGTVTGRPRRVGWFDTVVVRHARRVSGITGLSLNSLDVLTGLETVKICTAYRLNGELVTTYPANLKLLGECEAVYEELPGWSEDISNAKTLEDLPATTRAFVNRVAELTGIPIAIFSVGRNREQTNQVAPIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHL5</accession>
    <name>A0A398CHL5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02716">
        <property type="protein sequence ID" value="RIE02716"/>
        <property type="gene ID" value="D3H35_18885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="113" mass="11847" checksum="8DCA10647B15CF61" modified="2018-12-05" version="1">MLTISILLLLSTGCWDRREINDLAIVLATGVDLSEEGDVLLSAQIFIPRAAGGGPQGNTGGSGGNTTGDTFVRKATGKTIAEAMAKLQRKLSRHLFWGTARSSSSAMQPLATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHN8</accession>
    <name>A0A398CHN8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01950">
        <property type="protein sequence ID" value="RIE01950"/>
        <property type="gene ID" value="D3H35_14350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="63" mass="7325" checksum="84412F498126BBCF" modified="2018-12-05" version="1">MIHEADFSIAVSQIINDILRRGLQRGLRIRGFGLQAGRYIDGFDAQAKRTCRRRLRYRRGVCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHQ2</accession>
    <name>A0A398CHQ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_16460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02313">
        <property type="protein sequence ID" value="RIE02313"/>
        <property type="gene ID" value="D3H35_16460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024478">
        <property type="entry name" value="HlyB_4HB_MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12729">
        <property type="entry name" value="4HB_MCP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="213"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="270"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="532" mass="57554" checksum="452702892E92A500" modified="2018-12-05" version="1">MKWFYNLKTGVKLISSFLVLAVLMAFVGLFGISKLGTLNDNLEDMYDNQLVSVQSLMGAQVSLNELRVQLRKLYMASDPFMQKDVMESYKQEYDKIDDAIKDFRATDMSAASKAGLKQFEDSMVEYRDYYERGIALYQENKLDEMESLINGDYNTASGMTKGYLSKLVEINVSEAKKARDDGAKVYSTSRLITFIIVGFAFVLSIVFGYFISRIISGPLNRVVALVTKVADGDLRETIGLGTKDEIGKLGNAIDAMVRNLRNIVGSILGNAQSVSAASQQISASTEEIASGNANQASSAQMISELFQELSTAIHSVAQNTEQASELSEATIDKAREGAQVIQSSMDSMREVSGTMSRLEDDSQKIGEIIEVIEDIADQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLAERSSDATKQITGIIKGMQENTRQSVIAVQQSTSFSTQTEESFRRIAAFVNDAGNKVTEIAAASEEQAAQASTVLEAVESISAATEEAASASEETAAAAQSLALLAEDLQHAVSVFKVNTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI29</accession>
    <name>A0A398CI29_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00809">
        <property type="protein sequence ID" value="RIE00809"/>
        <property type="gene ID" value="D3H35_26855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="10"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="403" mass="44567" checksum="EF103C8CB10B9723" modified="2018-12-05" version="1">MTMPNRQFDLLTLQQAMDILGVSRATIDRWRKDKRLPYVKIGKEIFVEEKKLHSWMQTFSQGNAEPLAKETPSASPRLVTIGYQSGAALLWSPLIIRKLGLFEEQLQRLCPDENIRIEWVHAPNGIELVEELIAGRVRIASVGDFPMMMSMALSRVLTKFKPVLLAFDGKTPVGEGISLVVPSSRSSRKPLSAASIATVGHSSASFRLDEWTNALDLRTPPIIHRGMSDCLDGIVGGSLDASVLWEPYLSWAKMAGAGVTVSGEGTGNDYLTGLLADDRWAQDNEAVTVAYLAAHLQAHQFIRNSPDMAARLIHGATGYPVEVVAKAISKIRWDASLYNRDLQTLESLDKEDPVRFPESQPKPGVSRHLPIRKPYLHYAADSLKLPALPDAPLPGDWSEQPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIK7</accession>
    <name>A0A398CIK7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diacylglycerol kinase family lipid kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_15875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02215">
        <property type="protein sequence ID" value="RIE02215"/>
        <property type="gene ID" value="D3H35_15875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="15"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="341" mass="36240" checksum="C2CE334188DA691C" modified="2018-12-05" version="1">MMRNKSTNGRHGKGRHAIVILFVVNESSGNGRGRKIWRQVKQELRRRSISYRVVAAATEAESARQTKAAIDSGDLKAIAIIGGDGSLHSLLPHLAGSGIPIGLIPSGSGNDNALTFGIPRNPMKALDIVLNGQPRAADLIATIEAPPAGAHNTPHAFDSAGSPSSPPRYSSTAIAVGLDGAVADDVNRSRYKRWCNRLGVGSLAYLIGLLRMLAVFKPQRIAVTVDGERREFERGWLVAIASHPTYGGGLRICPDARADDGELHVCVVHDCSALRILSVFPTILNGSHVKQPYVAMLRGKSVLIEAPRPLLAFGDGEPVGRTTIRADVHAGQLLFLTAASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIP9</accession>
    <name>A0A398CIP9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2619 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00738">
        <property type="protein sequence ID" value="RIE00738"/>
        <property type="gene ID" value="D3H35_26450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020390">
        <property type="entry name" value="Uncharacterised_YqhV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10942">
        <property type="entry name" value="DUF2619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="87" mass="9074" checksum="A6D0D24E548A0D3B" modified="2018-12-05" version="1">MDKSVFGMALLRILSGSLELTAALVMLKLNDVQKALTVNSTLALVGPLVLISTTAIGLVGIADKLSPAKFIWILAGVGCLLIGILRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ90</accession>
    <name>A0A398CJ90_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphatase PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_15685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02182">
        <property type="protein sequence ID" value="RIE02182"/>
        <property type="gene ID" value="D3H35_15685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="6">
        <location>
            <begin position="49"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="220" mass="26093" checksum="C6821F6006885150" modified="2018-12-05" version="1">MLQRVRDIQWKKYTPLIFMLVFPFLGMMYKWTNRSDQDVSSLVTSIDQAIPFIKYFSLPYSIWIFYIYVCLVYFFRKDVNVYFRALLTYIVCALVCYMIYSVFQTTVPRPALTGNDPFTRLMEYIYNRDQPFNCFPSIHCFSSYMVMRMLWTSQFRNKWNMILITGMSSLIILSTLFVKQHVILDAVSGILLVEIVVPIIVLGERLVKVSRARQNRSYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJC9</accession>
    <name>A0A398CJC9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_12230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03426">
        <property type="protein sequence ID" value="RIE03426"/>
        <property type="gene ID" value="D3H35_12230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="68" mass="7285" checksum="00EB9067E36198DD" modified="2018-12-05" version="1">MNTGLLIILVVVVMVAAVAATLMVGFSRSNNQEDTGYTANTGRKWGRLIALYAVSIILVAILFIALMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJI7</accession>
    <name>A0A398CJI7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_17650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02515">
        <property type="protein sequence ID" value="RIE02515"/>
        <property type="gene ID" value="D3H35_17650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="357" mass="39672" checksum="899D23A0A4DA18FB" modified="2018-12-05" version="1">MPQNEKTVRGPQDAFVEDIWTNLSLIRQRIKTTDLKVDSFELGTESKTLVLLLYMKSKCEPRLVKEVGAKLNGIHVEGLFGSNMVEEYLDTNKFSPFPQSQYTERPDAAITALIEGKVVILVNGTPNQLILPASLVAFLQAAEDYYQRFFFSSWIRLIRYLFFAVSLILPSAYVAITTFHPEMIPVSLLISVASSRDLVPFPAVFEAFAMELTFEVLREAGQRIPAAMGQTISIVGALVIGEAAVQAGIVSAPMVIVVSLTGISSFIIPHFELNLAVRLLRFSLLILAGMFGLLGLLIGIILILTHLIALEPFGVPYLSPLVPLDRLKLGDVLIRLPWTTMMKLKQRQQQKQKQNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJQ3</accession>
    <name>A0A398CJQ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_10905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03546">
        <property type="protein sequence ID" value="RIE03546"/>
        <property type="gene ID" value="D3H35_10905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="9"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="319" mass="36570" checksum="E973553E8C81C1A3" modified="2018-12-05" version="1">MNENEIRYSVIIPMYNEEEVIEETYRRLKSVMSRTGETYELLFVNDGSRDRCADIVRQYGEWDESVKLIDFSRNFGHQIAITAGMDYASGDAVIIIDADLQDPPELILSMIELWKDGFEVVYAKRVKRNGETRFKKWSASLFYRVLRASTDVAIPVDTGDFRLMDRKVCDQMKRLPENNRFVRGLVSWVGFRQTAVEYERDERLAGETKYPLKRMIKLCLDGIMSFSYKPLKLAGYAGALLSGAGFLYLLYVLYLALFTDATNKGWPSLIAIMLIFNGFVLLMLGIMGEYIGRIYDETKGRPLYIVRNFTGGAPGAMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJY4</accession>
    <name>A0A398CJY4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01168">
        <property type="protein sequence ID" value="RIE01168"/>
        <property type="gene ID" value="D3H35_22465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017187759" evidence="1">
        <location>
            <begin position="28"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="278" mass="31295" checksum="14949E0FA63AAAF7" modified="2018-12-05" version="1">MFTRKMLFTKVSTLLLTIFIAEGCSSKDSDDKADQVALTSLSDEFNESSSWSKWTKAIDVKTDDAYIGKFDINQTSEGHLYIEAVKGTWYGENTGHLSFKQVTGDFVASMRVKVAGKNTPIPQGSYDLTGLMARVPNQKTGEAYSDSNENWEYLSTGGHADSRIIDYKKNIRSSFTFQTADVNTDWIELRLARIGNDIVKLYKEDGGAWQFAEANRRDDFPDTLQVGFCLLTDLNGSPDNYTTIDYIRFQEPVLTDDMAKKIEDETAEDKDWIALLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK34</accession>
    <name>A0A398CK34_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02705">
        <property type="protein sequence ID" value="RIE02705"/>
        <property type="gene ID" value="D3H35_18795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="153" mass="17059" checksum="AC78488551390614" modified="2018-12-05" version="1">MSSTLKELPIRHWRAKSRGGSRECESRGCWKANRSRNGFRIIRSLPFLNCCRRSAGCRLRQSSGGPHRHPDRRNAVCPRSSGQLILDAPVSGGLLSEHTLQLVHSLASLCFFRHVAAASVAYVAITTYHQEMIPTVLLLNIANRARRSLFPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKL7</accession>
    <name>A0A398CKL7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal transduction histidine-protein kinase ArlS</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D3H35_28935</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00437">
        <property type="protein sequence ID" value="RIE00437"/>
        <property type="gene ID" value="D3H35_28935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041610">
        <property type="entry name" value="ArlS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18719">
        <property type="entry name" value="ArlS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="190"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="251"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE00437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="471" mass="53076" checksum="8805507EE53CBE6E" modified="2018-12-05" version="1">MRRWTSVFSRMPIKIKLTLGSAVLLALLFAGYNALQYLIMEKWIINREKDAAHRSMNGILNYFLERESGFTADELPDIRHYLEKVNRDDQRIRIIDASGVPILTVTDQLSETWLEPVSSAHEQLAIARDNEHSALILRSPLTIFEFEGTVEIVKSMDEFEELTAAISKVMYLFAIAAVGLSVLVGWLLSWRLLKPLQAMALTLRGVRDKGLQERMVPASNGDEIATLMHLFNEMMDKVEESFRQQSRFVEDASHELRTPIAIIEGHLGLLQRWGKENPEVLEESLEASQQEFARLKGLVQELLALSRAEKMTLVQDSAPMRPKDEIQAIVKRVALIFPAFKLLTDLEAVSNARLAMSGAHLEQILLIVLDNAVKYSYRSNEILIGADLRDDRVHIHVTDYGIGIPAKDLPLVTNRFYRVDKARSRELGGNGLGLAIAMRLVERYQGTLAIRSQESVGTTVTIILPLLPNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKN6</accession>
    <name>A0A398CKN6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_29850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00241">
        <property type="protein sequence ID" value="RIE00241"/>
        <property type="gene ID" value="D3H35_29850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017430125" evidence="2">
        <location>
            <begin position="23"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="184" mass="20943" checksum="456B2A9E297A1BB0" modified="2018-12-05" version="1">MKSKWIALLGAATLAFSVPAVAAAGPAHEHGHSHDNGHRHEKADQALDWSSYPADLQALKSQLDKLRDEQKDVYRQIHEQREQIKAANHSLTQEQRKKVFGKAKTLIEKLKASSQTIREKRDQKRAAWEQFHQHTAAKQWDAAKSDLQTIVERKKDILEDQRNIVKLQKQLTELLPAAPAPKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKR7</accession>
    <name>A0A398CKR7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsL</name>
        <name evidence="7" type="ORF">D3H35_30055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 5">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00271">
        <property type="protein sequence ID" value="RIE00271"/>
        <property type="gene ID" value="D3H35_30055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="124" mass="13575" checksum="E21C1D5171B698A7" modified="2018-12-05" version="1">MVKSKSPALQKGFNALKRIETDLSAPQKRGVCTRVGTMTPKKPNSALRKYARVRLTNRIEVTAYIPGSATICKSTVSCLFAEAGKRPSGVRYHIVRGALDTAGVNNRKQARSKYGAKRPKVKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKV3</accession>
    <name>A0A398CKV3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_24505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01518">
        <property type="protein sequence ID" value="RIE01518"/>
        <property type="gene ID" value="D3H35_24505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="252" mass="29610" checksum="EEE6AEE2D96B6D2E" modified="2018-12-05" version="1">MKQQQKHKTITDIARHVKNNESSTFRGRANEAVFKIGKSFDIDYENRAVLNSKKTIEYAFSEKEMHLLAALLAVSKHRPLWHKNRKWENVRISEIFDYHTKLIEEINKMPSEFQQEITADERFEQAEQIQQHVQRIHILVEKLEFLFYLSPAKVGVEILRIVEERVDEFVEGAFEALGEYEKSDALEILEKEGAEVSEEAVREQIKRNTDEKLEKIRTGIDPEVHLLDNLIGDHLKKANDEYTNQFFNSEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKY1</accession>
    <name>A0A398CKY1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">MEP cytidylyltransferase</fullName>
            <shortName evidence="7">MCT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ispD</name>
        <name evidence="8" type="ORF">D3H35_30025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00281">
        <property type="protein sequence ID" value="RIE00281"/>
        <property type="gene ID" value="D3H35_30025"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="229" mass="24447" checksum="1106FB813F67386B" modified="2018-12-05" version="1">MRWGAVVVAAGRGTRMGAADNKPYLPIAGRPVLAYTLEAFERCDAVETVVIVAAPGEEERARELVAKEGFRKTAAVVTGGAERQDSVLAGVNALDTDGVLVHDAARPLVEPERIAACCRSAEENGAAALAVPVKDTIKVTDKDGFMVATPDRSALWAVQTPQAFARAELIEAHRLAREAGAAATDDTMLMELLGRTVAVVPGDYRNLKITTPEDLLVAELFLGRRQEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL40</accession>
    <name>A0A398CL40_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_25070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 66 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01618">
        <property type="protein sequence ID" value="RIE01618"/>
        <property type="gene ID" value="D3H35_25070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14745">
        <property type="entry name" value="GH66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025092">
        <property type="entry name" value="Glyco_hydro_66"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13199">
        <property type="entry name" value="Glyco_hydro_66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="564" mass="64164" checksum="F79A5C19C2E3A589" modified="2018-12-05" version="1">MIKDIYPLKAQYRSGEPISVALELENSGPSAAVWRAAINVSRLERLTQQRVEEVTLEGGESRTITLMLQGCEAEFDGFGVDVDLLGSEGGVLHSASTSFDVVSDWRRSTRYGFLSDFNARESGDEEDVKWLNKLHLNVVQFYDWMYKHDDLVADKNEYTDLMGRELSLDVVKEKVDLCHRYGMKAMAYGAIYAASKPFAELRPDWVLYQSDGKPYDFIDIFTIMDITEESPWHRHIIGEYKRAVELVDFDGIHMDTYGFPKTGNSIRDGQTKTVRLDEHFAKLIDNTKAELSRSKDDIGLIFNNVGNWPVAPVASAEQDALYIEVWKPYERYHHIRQVLQWAQHTGGGKPVILAAYLKPFRTETDPERARFAGLLLTAAIAAHGGYHLLAGENSAVLTQAYYADYTTVGEQFRSELRRYYDFNIRYANLLYAEELKDVSMTHADGDNLEYVFDGLAYSTYGEAGKVWTVIRESESRKTISFINLTGNDEDYWNEGKNRPERLTDIKVRILLESEVAGVFLASPDDNLGRARPLPYVVTNSLRGLTLELMLPALEVWSVLWIDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL51</accession>
    <name>A0A398CL51_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Toxic anion resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_20470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TelA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02980">
        <property type="protein sequence ID" value="RIE02980"/>
        <property type="gene ID" value="D3H35_20470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008863">
        <property type="entry name" value="Toxic_anion-R_TelA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38432">
        <property type="entry name" value="PTHR38432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05816">
        <property type="entry name" value="TelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026508">
        <property type="entry name" value="TelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR026508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="379" mass="42095" checksum="0104CEA3597DDF43" modified="2018-12-05" version="1">MSFSMEVASPEEIKTAIEQEVKPVPEELAKLKEAADSNVATIMALDLESLEKRKEILQSIDTFGLNTMKSSSDKNSLLQVSVGNLSKTGDEGGQVAKGLAELHTQLKDLDPSVIDFAKTGFLGKLFNPLRAYFLKYQKADAVIADIVVSLDKGKSTLKNDNTTLEIEQQALRDLTKRLQKEIQLGVLMDESIESQIEAAKLRNEDADKIRFITEEVLFPLRQRVMDLQQMLVVNQQGIMAIEVVIRNNKELIRGVDRAKNVTISALKISVTVASALYNQKIVLKKIELLNQTTNELIAGTSKMLKEQGAAIHKQSLETSISVDTLKQAFTDVLAALDSISTYKQEALPKMRETIGQFRELAETGEKQIQRLEKGHKLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL69</accession>
    <name>A0A398CL69_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_20580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03000">
        <property type="protein sequence ID" value="RIE03000"/>
        <property type="gene ID" value="D3H35_20580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="438"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="538" mass="61951" checksum="45AC9850BDD94697" modified="2018-12-05" version="1">MMMQLLLVDDEMNVADTLADTIPWHSIGIDTVHKAYSSAEALNLLNMHEIDIVITDVRMPEMDGLELARRIFLYWKHIKCLLLTAHADFEYAQAAIKHNIQGYMLKPIDDKELVRQLSAVVDTIRTERENESNYNRAMAAMRHHLPRIQAELLQSLLQGTRMTETKLAEQLKLLELPVGIGQDIFMMLVRFKERLCDYNSFEISLMEYAIGNMAKETFQDHFDTWYCRDVHEYLAFALIPRDASDGSSLEHLNRLANQFQMNVQRFLKMPISVLSGQAGRFPDEVTKMYNNLLLLFGRRFGDDKDLPVYIAGRGEMAAIGTLVSLYEPPLFVHLMEAGHWEAVSAKLHAVMNELETDWSESSEQLTEAFFAIFSAFSYIAHKSGRNLADLIGAEYVLGKELQPARTVKHLREWTVSVLDTFRRNARNETRSARASAVKEAQKFIISHLSGDLSVQMISDVLNMHPAYLSRLYKLETGENISDYIARLKMEKVVLLLKTSTKKIYEISIEVGYQNPHYFIKLFKKHFGFTPQEYRNMNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL72</accession>
    <name>A0A398CL72_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04096">
        <property type="protein sequence ID" value="RIE04096"/>
        <property type="gene ID" value="D3H35_09135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="84" mass="10183" checksum="E2B5E2226F0B7D2F" modified="2018-12-05" version="1">MCGLPYISGKSVIERQQWEHVTHIVWKSVIERQQWEHVPYISGKSVIESQQWEHVPYISRKSVIERQQWEHVPYISRKSVIERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL84</accession>
    <name>A0A398CL84_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03175">
        <property type="protein sequence ID" value="RIE03175"/>
        <property type="gene ID" value="D3H35_17535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007405">
        <property type="entry name" value="Phage_KVP40_Orf299"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39961">
        <property type="entry name" value="PTHR39961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04308">
        <property type="entry name" value="RNaseH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="191" mass="21374" checksum="36631D4C5E588544" modified="2018-12-05" version="1">MSAKQRLSVPGESSFQSVAERNLSPGDVLARIMAFISQNPKAAYHFIIGTDSQVHRGYTKFVTGIIIHRLGQGAWACYRQTALPRELTSIREKLVLETSFSQRVAAFFDADAVGRMEDLLLPYVYQGAMLETYIDIDAGTEPAVNKTSLYVQEMMDRVEAMGMYAPRVKPEAYAASSYANRHTKKPIRLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLV8</accession>
    <name>A0A398CLV8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sigK</name>
        <name evidence="9" type="ORF">D3H35_12760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000038">
        <property type="protein sequence ID" value="RIE03240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03240">
        <property type="protein sequence ID" value="RIE03240"/>
        <property type="gene ID" value="D3H35_12760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014209">
        <property type="entry name" value="RNA_pol_sigma-K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02846">
        <property type="entry name" value="spore_sigmaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="8">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="233" mass="26522" checksum="D475ABBE63C309DC" modified="2018-12-05" version="1">MPGFIASIALFVKQLALLVSYVKNNAFPQPLTDEEEALHLQRMSQGNAHSRNLLIEHNLRLVAHIVKKFDNTGEDLEDLISIGTIGLIKAIESFQTGKGTKLATFAARCIENEILMHLRSLKKTRKDVSLHDPIGTDKEGNEITLQDILGTEPDEVVEKVQLKIEKSKIYRNLDILDEREQEVIRGRFGLDGGGDERTQREIARELGISRSYVSRIEKRALMKLYHEFYKAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLY3</accession>
    <name>A0A398CLY3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04356">
        <property type="protein sequence ID" value="RIE04356"/>
        <property type="gene ID" value="D3H35_07100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019152">
        <property type="term" value="F:acetoin dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045150">
        <property type="term" value="P:acetoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024699">
        <property type="entry name" value="AcuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021278">
        <property type="entry name" value="AcuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="210" mass="24337" checksum="3856F55FC47E7483" modified="2018-12-05" version="1">MEHFKTFVTRTVEREGRLLLVEGPIAPEKLRRCKLHPALDAFRRPAEQHAALVEIAELPEGRIIAAREGDLIVGYVTFHYPDELERWSEGGMDDLIELGAIEVADEYRGLGIAKALIATAFADEQLDNVIVYTTEYYWHWDLEGSRLNVWEYREMMENLMKTVGMVWFATDDPEICAHPANCLMVRIGKDVPLSSAERFDRVRFRQRFMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM49</accession>
    <name>A0A398CM49_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Riboflavin kinase</fullName>
                <ecNumber evidence="11">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">FMN adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D3H35_11625</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ribF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="11"/>
    <dbReference type="EC" id="2.7.7.2" evidence="11"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03330">
        <property type="protein sequence ID" value="RIE03330"/>
        <property type="gene ID" value="D3H35_11625"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11" id="KW-0288">FMN</keyword>
    <keyword evidence="11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="12">
        <location>
            <begin position="192"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE03330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="331" mass="35738" checksum="D6303B24CD8F93E7" modified="2018-12-05" version="1">MERYELTAASIGRIEGSATLPATDDGLCLAIGFFDGVHIGHAEVIRQAVSIAEERGLSPAVMTFDPHPRAVLGQDPQFGTVLTPLDDKLSLLAELGVKAAYVIRFDRDFAEISAERFVRELLLPLGVRTAVVGFDFGFGHRGEGKAESLSAFSGGAISVQVVEAVFLDGCKVSSTRIRERLAEGDASVASQLLGRPYVIRGEVIHGDKRGRQLGFPTANVKAFQPYVIPRNGVYAVSVDIFSASGRIESSHHAVLNVGIRPTFDAPGGEVKLEAHLFDFEGDLYGRELALSVHTFLRPEMKFDGIEALVAQIRTDAEQAKQLLSKMTANDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNA9</accession>
    <name>A0A398CNA9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YbhB/YbcL family Raf kinase inhibitor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_18955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02729">
        <property type="protein sequence ID" value="RIE02729"/>
        <property type="gene ID" value="D3H35_18955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017258624" evidence="2">
        <location>
            <begin position="28"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="184" mass="19714" checksum="44699A0BC426ADEE" modified="2018-12-05" version="1">MMKKGFGVLLAGLLLLIAAACSNNEGSDKKGKFELTSSAFKNGGRIDEKYTGANTNFPLAWNGAPKGTKSFAVFTVDLHPVADEWVHWVVIDLPADTKELGENVSGTDQLPQGSKELGNSFGPKGYGGPTPPAGSGDHEYKTILYALDVEKLDIPDSVSYAGFSKLVESHVIEKTELSGFYENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNB0</accession>
    <name>A0A398CNB0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_10520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic sulfate-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03720">
        <property type="protein sequence ID" value="RIE03720"/>
        <property type="gene ID" value="D3H35_10520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902358">
        <property type="term" value="P:sulfate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005669">
        <property type="entry name" value="Thiosulph/SO4-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30368">
        <property type="entry name" value="PTHR30368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00971">
        <property type="entry name" value="3a0106s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0574">Periplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017189753" evidence="6">
        <location>
            <begin position="40"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="363" mass="38990" checksum="528E25CABC5091CE" modified="2018-12-05" version="1">MHPGVRPPTLRQNTGFARYAVFLLIILLLAGCADNGEQASGSNDEGVGGSKGGTTLVIGAYSVAKDALQDILPAFKEEWKAKTGQDITFQESYEASGTQARAIVGGFQADVALLAMEGDMDKITKAGLTSDAWKKGADGGMVTNSIVVLGTREGNPLGIKDFDDLTRDGVKVLYPNPQTSGGAQWDINAIYGAGLKRSEKETGAKDPVAAKAFLAAVHRNIESMDKSGRASMAAFEYGVGDVIVTYENELLARIAKGVNYDIVVPSSTILIQNPASVVERNADRHGVREAADAFVAFLHGEKAQQLFAKHGFRPVLPALAEKLKADYPQPEELFDIHYLGGWKEVRETLYAKRGVWYQVLAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNG4</accession>
    <name>A0A398CNG4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03862">
        <property type="protein sequence ID" value="RIE03862"/>
        <property type="gene ID" value="D3H35_09950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="245" mass="27505" checksum="43D2B3F59877824B" modified="2018-12-05" version="1">MEKAVTFGDSRLVYDSASGLPLRWEKEDEALTTFVFPEPFVSLELNGISAANDAEQMIAIRNVMLTGARSELIHDEVKTVSEREKRLVIRTKIDGHWELTTTFLYCGDASLAVSVDVKTTNDSRNPVLRAVRLNLGGFGYRRLDEWELLMPGYIPELTLPIDLHRKLDGCEDRAVFGSRKKDEPGNGTSIMGVYHAESESAMLSWWMSDMFPAVSTMTLIKEEEQLRRKASSIARASLNAASRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNH0</accession>
    <name>A0A398CNH0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Divergent polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00464">
        <property type="protein sequence ID" value="RIE00464"/>
        <property type="gene ID" value="D3H35_28630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10936">
        <property type="entry name" value="CE4_DAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006837">
        <property type="entry name" value="Divergent_DAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30105">
        <property type="entry name" value="PTHR30105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04748">
        <property type="entry name" value="Polysacc_deac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017376176" evidence="1">
        <location>
            <begin position="24"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="274" mass="29891" checksum="223DA08C0119E199" modified="2018-12-05" version="1">MKKWQPISIALVGAFALAAQAFAEPSERPQNHSGQQSEARRQIAVVIDDFGNNMKGTQEMLDLPIKLTVAVMPFLPTTKQDAEAAFAKGHDVIVHMPMEPISGKKSWLGPGAILTDLPDAEIRRRVEAAIKEVPHAVGMNNHMGSRVTADARVMRIVLEVCKEHGLFFLDSRTSFRTVVPKVAKEVGLQVLGNDVFLDDVYSSRHVAKQIAIIRKFLQSHPTCVVIGHVGSPGLVTSGALKSAIPALKSEAEFVKVSQLLPTPVLPTERKNDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNH3</accession>
    <name>A0A398CNH3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aliphatic sulfonate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_16260</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02278">
        <property type="protein sequence ID" value="RIE02278"/>
        <property type="gene ID" value="D3H35_16260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010067">
        <property type="entry name" value="ABC_SsuA_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01728">
        <property type="entry name" value="SsuA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="9">
        <location>
            <begin position="87"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE02278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="386" mass="41261" checksum="87509DAB0CAA716D" modified="2018-12-05" version="1">MTGQPDPIDASKQQEEELPVKPKQSYYPKARIGIAALVLVLTLTLLAACGKSDNSAGNGSTSPSASPSESSSGGASPSAEPSKSAEGVTVNLEASQIGPILIAKEKGWFEEEFAKYGAKVNYQALQSSSQFLEGIVSGRLDFARIGYIGTITGQAANIPFVTLSEGSDGAGDGIIVQKDSKVKSIKDLKGKKVAVSKGSSSWGLLLRALEKEGLKVSDIQLINLQPDEAQGAFQSGQVDAWGIWEPFRSNQVNNQGATVIANSQLIGAYTPGYNIARKAFADEHPELVVAYLKAYERALQWENQNFDEAVKLLAGIKKLDEATVNISLKNNVPLNSPVSDEANKSQQKTADILLSLGEIKEQLDVTKVVDNSFITKALEEYKTENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNL4</accession>
    <name>A0A398CNL4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_03195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04956">
        <property type="protein sequence ID" value="RIE04956"/>
        <property type="gene ID" value="D3H35_03195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="307"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="568" mass="63883" checksum="07CF84D490D404FF" modified="2018-12-05" version="1">MYGAILYGGKLIVVPKEVSKNPREFLTLLRTEKVTVLNQTPTYFYQLVEEDRLQAEPLLLRMVIFGGEALKPSLLENWKSKYPNVELINMYGITETTVHVTYKQIKQTEIEGHISNVGQPLPTLHTYILGSDHKLRPVGVPGELCISGAGLARGYLNQPELTAEKFVANPFAPGERMYRTGDLARWLPDGNIEYLGRIDEQVKVRGHRIELGEVESALRSHESVKEATVIARKDEEGSAYLCAYFVANGNLGAAELRKRLSEMLPQYMIPSFFVRVEQMPLTPNGKLDRKALPSPEGTLERGTVYEAPRNALEETLANIWQGVLGVSAIGIADNFFELGGHSLKATTLVSRIHKELNVQVPLREVFQSPTIKELAQAIRGMEAHAYASIEPAPLREYYPVSSAQKRMYILSQLQGADESYNMPGAVMMEGKVDRERFERAFRQLIARHEALRTSFEWVEGEPAQRIHLEVDFEISYKKAEEGGLRQIAEFIRAFDLGQAPCCGWGCWSWSRSARCCCTICTILFPTGCPWTFSYGSLSGCMGVKRCLPRGCNTKIMRYGSRRSCRAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNL5</accession>
    <name>A0A398CNL5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Corrinoid adenosyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cob(II)alamin adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cob(II)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cobinamide/cobalamin adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_09075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:28671"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:11528"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:58503"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04085">
        <property type="protein sequence ID" value="RIE04085"/>
        <property type="gene ID" value="D3H35_09075"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="5">
        <location>
            <begin position="3"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="194" mass="21702" checksum="CBFFB17C565C2B36" modified="2018-12-05" version="1">MKLYTRTGDEGKTSVIGGGRVRKDDARVEAYGTVDELNSYVGQAVAVLLKAPEEKLQQLAERLILVQHELFDCGSDLCYAAPSPDKMKVSAEMTERLEVWIDESEAQTPPIERFILPGGSESAALLHVCRTVCRRAERRVVTLGVDQPYPDEVRRFLNRLSDFFFAAARLANAALSVPDIEYERGAAVFRRREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP07</accession>
    <name>A0A398CP07_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02488">
        <property type="protein sequence ID" value="RIE02488"/>
        <property type="gene ID" value="D3H35_17480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="70" mass="8034" checksum="4993CF5843474D7F" modified="2018-12-05" version="1">MSEHTNRPNADEAEEPKKVSLGDAMKQMLERKKQAQAQARGPKQRQADGEHKMKTQIHKVQNNQKRRTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP45</accession>
    <name>A0A398CP45_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">OsmC family peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OsmC/Ohr family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01657">
        <property type="protein sequence ID" value="RIE01657"/>
        <property type="gene ID" value="D3H35_22250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="152" mass="16816" checksum="CCD99926711F6A89" modified="2018-12-05" version="1">MAAVQTFKATAHLQDGVKVITRSRQFELIIDEPKSLGGTDTGLNPVEALLASLGACQSIVARVYASKFGIELDDFRVEVEGDIDLDGFFNKSDVRPGYSDIRYSFYIRTNSPRDKVEEFVQFLESKCPVGDTIANPVNLKLDSIIIEEPIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP58</accession>
    <name>A0A398CP58_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_05925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04162">
        <property type="protein sequence ID" value="RIE04162"/>
        <property type="gene ID" value="D3H35_05925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="217" mass="24106" checksum="FBB35A0B4D2E6DE9" modified="2018-12-05" version="1">MKFSMSKSKEPAKRSPGRPKVVDQGTLPMRDAILRMASALFMEMGFEPVSVNQVAEKTGVTKASVYYYFTSKAELFTASVSEMMGRIRESTLYHLRQTGDLRTRLNQLAAAKLRHPHIEFESMMREAMPSLSEEQRERIRSAEQRIHDAVTDGFIEAMEKGEIAKANPLLLSHAFGSLLMMGNRASELAGGSSGKPLAEQIVDLFWCGISQNSNGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPF3</accession>
    <name>A0A398CPF3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03199">
        <property type="protein sequence ID" value="RIE03199"/>
        <property type="gene ID" value="D3H35_19175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="117" mass="13434" checksum="2FB51D1F07A7E75B" modified="2018-12-05" version="1">MQKVSQEEEFRRITGEDRLTVAVFKTTWCKDCHFIDPFIPDVEKAYADRLTLIEIDRDDMPDLCSELNILGIPSFIAFRKGQELVRFVSKLRKTRDEIEQFLDRAVAVSAAVAPVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPI7</accession>
    <name>A0A398CPI7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galE</name>
        <name evidence="10" type="ORF">D3H35_18275</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02628">
        <property type="protein sequence ID" value="RIE02628"/>
        <property type="gene ID" value="D3H35_18275"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="9">
        <location>
            <begin position="3"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE02628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="329" mass="36056" checksum="F563F45BA831ECF4" modified="2018-12-05" version="1">MAVLVTGGAGYIGSHAVAALLEKGEQVVIVDNLYQGHREAILGGKLYEGDIRDAEFLEKVFAENDIDGVIHFAANSLVGESMKDPGKYYHNNVYGTLCLLEQMVKAGVKRIVFSSTAATYGEPEKVPIEEFDRTLPTNAYGETKLSMEKMIRWFDVAHGVKSVSLRYFNAAGAHESGRIGEDHEPESHLVPLVLQVALGQREFISVFGDDYGTEDGTCVRDYIHVSDLADAHLLALDRLREGGESSVYNLGCGNGFSVKQVVDIARQVTGHPIPAKIEPRRSGDPAILIASSDRARSELGWSPRRDKLEDIIASAWKWHSANPKGYGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPJ4</accession>
    <name>A0A398CPJ4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA1(Val) (Adenine(37)-N6)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01411">
        <property type="protein sequence ID" value="RIE01411"/>
        <property type="gene ID" value="D3H35_23880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="28"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="265" mass="29748" checksum="7A0459A111C2BABB" modified="2018-12-05" version="1">MAETANTDAILQPGERLDDLLSYDMRIIQSSEVFSFSLDAVLLARFAALPPRGRILDLCTGNGVIPLLLTTRTSACVDAVEIQPRLADMARRSIRLNGLEERISVIEDDLRAWTPPNGEYDAVTVNPPYMPLQSGDRKENIHQAMARHEIGCTLEDVVAACARCVKTGGRVSMVHRPSRLVEITEAMRRHRLEPKRMRFVHPRSDAEANMVLIDALKGGRPEVRLLPPIIVYKGDGRTYTEELLDIFYGRRTELADSTGKQEEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPL8</accession>
    <name>A0A398CPL8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04120">
        <property type="protein sequence ID" value="RIE04120"/>
        <property type="gene ID" value="D3H35_09265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="40" mass="4513" checksum="7B1C914F2D648921" modified="2018-12-05" version="1">MKGISLATGDYIWIAEADDSCSDVFLEKMMESFEADDKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPP3</accession>
    <name>A0A398CPP3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000026">
        <property type="protein sequence ID" value="RIE04505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04505">
        <property type="protein sequence ID" value="RIE04505"/>
        <property type="gene ID" value="D3H35_05735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="63" mass="6729" checksum="AC2357E47B73A669" modified="2018-12-05" version="1">MPDCLRVSKFAPLAAPRQAADSTVTVVRGRRTALIAIAALNLLLFGFYCVLFISGGHPAWKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPP8</accession>
    <name>A0A398CPP8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02708">
        <property type="protein sequence ID" value="RIE02708"/>
        <property type="gene ID" value="D3H35_18835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="63" mass="7077" checksum="198DB0E7E76245FF" modified="2018-12-05" version="1">MIPLACHAVFKAAPGPSDGGRYQYEFPLHFRFQSSVRFQDKGRHSETTKMSRSRAKGSFRASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ55</accession>
    <name>A0A398CQ55_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anti-sigma F factor</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Stage II sporulation protein AB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spoIIAB</name>
        <name evidence="5" type="ORF">D3H35_05430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anti-sigma-factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04582">
        <property type="protein sequence ID" value="RIE04582"/>
        <property type="gene ID" value="D3H35_05430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016989">
        <property type="term" value="F:sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030436">
        <property type="term" value="P:asexual sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042174">
        <property type="term" value="P:negative regulation of sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00637">
        <property type="entry name" value="Anti_sigma_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010194">
        <property type="entry name" value="Anti-sigma_F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01925">
        <property type="entry name" value="spIIAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 3" id="KW-0749">Sporulation</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="4">
        <location>
            <begin position="31"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="142" mass="15566" checksum="7CABF76F9BB7BD68" modified="2018-12-05" version="1">MKLSFAARSENESFARIVVASFVSQLDPTLDQLDEMKTVVSEAVTNAIIHGYDGSANGVVTLEAEIDGDTVSLSISDQGRGIEDLDLARQPLFTSRPELERSGMGFTIMENFMDEFEVDSAPGGGTRLRMKKRIESKKALFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQH5</accession>
    <name>A0A398CQH5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF115 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02067">
        <property type="protein sequence ID" value="RIE02067"/>
        <property type="gene ID" value="D3H35_14990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002826">
        <property type="entry name" value="MptE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01973">
        <property type="entry name" value="MAF_flag10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAF_flag10" evidence="1">
        <location>
            <begin position="191"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="460" mass="51649" checksum="834EA2C974067001" modified="2018-12-05" version="1">MNNANHIIHRAAVSGQSPTISLEKARNGMWTGFTETAGVPFYLHSRYDPVNEAERFIAAQLKDWADDRPERIVIYGMGCGHHVKALLKETHGSDVIVEVWESNVPAFSLMESKGVFEGLLEEPRLMAVVTEELLLFSERIQEWQGQRVLVIVHEPSLRIVPPELEPLKRVLRDYQMQKNSAIVHRDLLQANFDRNVRTMHPSLSLFQDMHAVPAILISAGPSLVKSLASLADASKYALLGAVGTVVSLLLSHGIRPDFVVMSDPQPNMLDQLQGWETEEDIPLFYLSTLYSEVVERYRGPQFILYQEGFDSAEEMASARGEPLVKTGGSVSTTLFSLSKLLRFEPICLVGQDLAYTDNSTHAAGTPLYQKFEEHTKGEYVKAVDGRGMVRSPRNLQIYKKWFEERALESNETYYNGTEGGAYIEGFSHVSLAEFVALTGKNDVAEAREYFQRQARSSFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQQ3</accession>
    <name>A0A398CQQ3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_05035</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04832">
        <property type="protein sequence ID" value="RIE04832"/>
        <property type="gene ID" value="D3H35_05035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="122"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="184"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE04832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="417" mass="48001" checksum="7C2D2EDC3AA20346" modified="2018-12-05" version="1">MSRRRSGESLLKRFRDKREARRERMLAFQEEYFRTQIRNKVEGSNDKVPARPKRWLFFGLAMVYVVMLANYLFAQWLMTFVYDYWFPEMGHTIGRQLITVVLMLFIFGLMMTLIRVIFDPGRHQLHLFISMMDAMRRMAKGDFSVTLDSNPRHGGQFGVLIKSFNEMASGLSNMEKVRQEFISNVSHEFQSPLTSIGGFARALQSEDLTPETRLHYLRIIETECSRLSKLSDNLLKLTSLESDHHPFEPKSFRLDRQLRQIVLSIEPIWRDKKLEMDVDLPAATIEADEELLSQTWINLLHNAIKFTPEGGTVRIRLTENERHLRIVIEDTGVGIAEQSLPYLFDRFYKVDKARSRVNGGSGLGLSIVRKIVELHGGEVSVHSRPMEGAAFTVVLPKLASSLQAPVQKPGEARSRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQU7</accession>
    <name>A0A398CQU7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ANTAR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02197">
        <property type="protein sequence ID" value="RIE02197"/>
        <property type="gene ID" value="D3H35_15770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ANTAR" evidence="1">
        <location>
            <begin position="116"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="185" mass="21277" checksum="80B1E4567B457192" modified="2018-12-05" version="1">MYKPLVWLEEGLDPAPVNKLAQACAALTCVRSENELKSSVASASAVILHVSYSKLRDRQITVIGLRRMPILWLCAEPRTPMELESGYSLDGILYPSMTGREIEWALKWGTRAFQERRRWLEEKEQLLQRLEERKWVDQAKGILCEIKGISESEAYDFLRKQAMNERKRIGEVAASIVKVYQLIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQZ0</accession>
    <name>A0A398CQZ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_03180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04953">
        <property type="protein sequence ID" value="RIE04953"/>
        <property type="gene ID" value="D3H35_03180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="775"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1806"/>
            <end position="1880"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="810"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="2641" mass="296522" checksum="38ECA485D1279EF8" modified="2018-12-05" version="1">MAAGVHAERSDETAGDVLAGDVLGELPVLEMPTDYPRPAVQSFKGDQIQFVLDGELSAGLNRIAAETGTTLYMVLLAGYSALLSKYTGQEDIVVGTPIAGRPHADVENIIGMFVNTLAMRSRPAGEKTFTAYLQEVKEVALQAYEHQEYPFEELVEKLNVRRDLSRNPIFDTMFSLQNMSEEETEIEEMRFSPYGFEHSASKFDMSLTAVETGREIGLSLSYCTAIYTKETAERLGRHYVALLRDISSQTEKQLKDLELLSAEEKRQLLHAFNDTKASYPADQTIHGLFEEQVKKTPDHTAVVLESESLTYAELNGRANQLARVLRGKGVGADRIVGILAERSLEMIVGILGILKAGGAYLPIDPDYPAERIGYMLEDSGADILLTQKRLEAQTMGFAGEVLHVDDERLYAGDNTDLDHTGSSKDLAYVIYTSGSTGRPKGVIVEHRSLVNLCEWHRNEFKITASDRSTQYAPSVFDASVWELFPYLISGSEVHLLDDVIRLDVNELNRYYHENDITITWMPPQVYEQFAALENRSLRILLTGADKVKGYQLNNYEVRNTYGPTESTVICTHYAISHNAANIPIGTPIANTKVHIVDAGGRLLQPIGIPGELCIAGAGLARGYLNQPELTAEKFVANPFAPGERMYRTGDLARWLPDGNIEYLGRIDEQVKIRGHRIELGEVESALRSHESVKEATVIARKDEEGSAYLCAYFVANGNLGAAELRKRLSEMLPQYMIPSFFVRVEQMPLTPNGKLDRKALPSPEGTLERGTVYEAPRNALEETLANIWQGVLGVSAIGITDNFFELGGHSLKATTLVSRIHKELNVQVPLREVFQSPTIKELAQAIRGMEAHAYASIEPAPLREYYPVSSAQKRMYILSQLQGADESYNMPGAVMMEGKVDRERFERAFRQLIARHEALRTSFEWVEGEPAQRIHPEVDFEISYKKAEEDGLRQIAEFIRAFDLGQAPLLRVGLLELEPERHVLLYDMHHIISDGVSMDILVREFVGLYEGQTLPAPRLQYKDYAVWQQAFMQSEAMKRQETYWLETFSGELPVLEMPTDYPRPAVQSFKGDQIQFVLDGELSAGLSRIAAETGTTLYMVLLAGYSVLLSKYTGQEDIVVGTPIAGRPHADVENIIGMFVNTLAMRSRPAGEKTFTAYLQEVKEVALQAYEHQEYPFEELVEKLNVRRDLSRNPIFDTMFSLQNMSEEETEIEEMRFSPYGFEHSASKFDMSLTAVETGREIGLSLSYCTAIYTKETAERLGRHYVALLRDISSQTEKQLKDIELLSAEEKRQLLNEFNDTKATYPADQTIHGLFEEQVKKTPDHTAVVLESESLTYAELNGRANQLARVLRGKGVGADRIVGILAERSLEMIVGILGILKAGGAYLPIDPDYPAERIGYMLEDSGADILLTQKRLEAQTMGFAGEVLHVDDERLYALDDTDLAHTGSSKDLAYVIYTSGSTGKPKGVMIEHKNVVNVVSWFHAQYELSLNPNIVLMTEYTFDPSVEQIFGTLLHGAKLHCIRKETLLNKYKFVQYVKENQIHIINGTPSLLHELLGDQQKIESLRVLISGGERLDDQQKEKFLKQGYVLHNHYGPTETTIDVIVGECTESERVRLGKPIKNTKVYICNNQGLLQPIGVPGELCISGAGLARGYLNQPELTAEKFVANPFAPGERMYRTGDLARWLPDGNIEYLGRIDEQVKIRGHRIELGEVESALRSHESVKEATVIARKDEEGSAYLCAYFVANGNLGAAELRKHLLEMLPQYMIPSFFVRVEQMPLTPNGKLDRKALPSPEGTLERGTVYEAPRNALEETLANIWQGVLGVSAIGIADNFFELGGDSIKAIQISARLHAHHLKMEIKDLFQYPTIGELSSCLRPVGRTIDQGLVEGEVELTPIQRWFFEQNFTDRQHCNQAVMLHRKDGFDERIVREVLAKLAEHHDGLRMVYHPGSEGYTQRNRGMEGEVFHLEVRDVTGDQQAEEEVIQACATEIQASMDLGKGPLLKAGLFKTAEGDHLLLAVHHLVVDGISWRIVLEDLNTGYRQAMNGEAIRFPAKTDSYQAWAKALQGYANSGQVLEEAEYWQAVERVEVKPLRKDSEVGAGLMKDGRHVSLTLTEEQTEKLLKQVNKAYNTEINDILLTALGLAIGEWNDSKQAAIELEGHGREEIGHEVDISRTVGWFTTQYPVILEMEQSRELSYQIKTVKEHLRRIPNKGIGYGLLKYGKAAAEGRTWKLKPEVSFNYLGQFDQDVETGLFAGSRYGAGGSVSPNVERTSTLSINGMVLGGHLQLAIDYNGKAYEADTIEELAAGYKRHLETIIEHCANRRETEKTPSDLLFNELSIEALDQIHEAFMHVGKVDNIYPLAPLQQGMLFHHVFDPGSHAYFEQTSFEIDGYLDVGLFEKSINTLIERYDIFRTVFHYGEGNRLLQMVLRERPIQIQLEDLAEYGIEEQNGVIEQFKQKDKAQGFDLSEGPLMRLALFRKGTAGYTMVWSFHHILMDGWCLSVVAKELFAIYQSLREQKPHGLGPVTPYSQYIKWLGKQDRAAASQYWEGYLEGYELSVTLPTLGNQQSEAYMLEKMSLTLEEDLTRRLTRTANEHQVTVNTWLQTIWGVLLQTYNGVDDAYSARSYRAVLPRLRALSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRA4</accession>
    <name>A0A398CRA4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_02900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05095">
        <property type="protein sequence ID" value="RIE05095"/>
        <property type="gene ID" value="D3H35_02900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026283">
        <property type="entry name" value="B-gal_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="PTHR23421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006336">
        <property type="entry name" value="B-gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_35" evidence="6">
        <location>
            <begin position="11"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="595" mass="67628" checksum="75D0203CA8742547" modified="2018-12-05" version="1">MSTFGVDAGLFVFNGRPIRLISGAVHYFRIVPAYWEDRLLKLKACGFNAVETYIPWNLHEPREGRFNFEGIADVTRFIELAHKLELFVLVRPSPYICAEWEFGGMPSWLLADANMKLRCMHRPYLDKVDAYYDVLMPLLKPLLCTNDGPIIAMQIENEYGSYGNDKAYLDYLRDGMIRRGVDVLLFTSDGAEDSMLQGGSLIPEVLATANFGSKPEKAFAKLAEYQPDKPAMCMEYWNGWFDHWGEEHHAREYDDVAGELDNMLRSGASINFYMFHGGTNFGFFNGANDFGRYEPTVTSYDYHALLNEAGEVTDKYMAVREVIARHVGPPAVPLPEPVKKMSYGAVRLTEQAKLFDQLDRLSRPVTSVYPETMERLGQDYGFVYYQTQVSGPRPKSKVVIQEVRDRALVYLNGDYQGVIDRNEHDNTLDMNAHDIAVEISPEGSKIGILVENQGRVNYGWMLKDSKGITEGVRLAGQFLFNWEMYSLPLDDLSELRFGLLREEERSVASLNSPSFFRGTFEVSEPADTFLKLEGWNKGVVFLNGFNLGRYWAKGPQQTLYVPGPLLLEGKNEIIVFELHGTIDPVVRFQDYMVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRD4</accession>
    <name>A0A398CRD4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01474">
        <property type="protein sequence ID" value="RIE01474"/>
        <property type="gene ID" value="D3H35_24275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="224" mass="24675" checksum="E4EAB5000B591A2D" modified="2018-12-05" version="1">MWKWFEWAARIIVTALLLSFLCVWTTGYIVNSYMQTLLKQLNLPIETQPFALSGVWGKLWGAEEPSKAAESTPKASPESSASPRAVEPSSSPTASPSDAKTDETSGTQREPESSPEPGPDPAAEGVDGTVQEEDGSVPVTGEQLEEIENRLTDDQKQQLYRTIMPKLNADQLQTMSDYLQDGLTTDELEKVKSLIQPLLSNEEYAQMMELLQGSAKTEPIAMQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRG2</accession>
    <name>A0A398CRG2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03859">
        <property type="protein sequence ID" value="RIE03859"/>
        <property type="gene ID" value="D3H35_09930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="154" mass="16838" checksum="82DF50104BA0D42B" modified="2018-12-05" version="1">MHLRSGRRDQLFGLVSPVKMFTAQRIKDVHLRTISQGCAPPDRNVRIALHLCDKQVSGRIFRGATEYLKGVRAVRFRGIGCDQKAGYDAHESNWILSTLTETSAILQKAYYLSPGSGGSGHTACCLNDAQSGRRIGMPKVASEARAALPLSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRH6</accession>
    <name>A0A398CRH6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_24485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01514">
        <property type="protein sequence ID" value="RIE01514"/>
        <property type="gene ID" value="D3H35_24485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="123" mass="13780" checksum="BD8BA8214292AF60" modified="2018-12-05" version="1">MITIQSETDLRALNSRVFPELLVQFVTDLLSDHSEELGGDEEFLHENPIHLCETNDPLLSWLAQSPFGPEYVERIVLPGLTLYRVGVLLDNDAFVQYLILAGTLDGETECWLAENASVGGDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRM6</accession>
    <name>A0A398CRM6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mannose-1-phosphate guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05202">
        <property type="protein sequence ID" value="RIE05202"/>
        <property type="gene ID" value="D3H35_01375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="57" mass="6193" checksum="FFA7E55D592F683E" modified="2018-12-05" version="1" fragment="single">AYAGMPRLSIDYAVMEKAKTIYCLPVNCGWDDIGSWGSLLRHLSSDRAGTSSTARSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRQ8</accession>
    <name>A0A398CRQ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_01605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05243">
        <property type="protein sequence ID" value="RIE05243"/>
        <property type="gene ID" value="D3H35_01605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="7">
        <location>
            <begin position="130"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="130"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE05243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="230" mass="26479" checksum="9D58C9ECD56C3A88" modified="2018-12-05" version="1">MNDVYTVLVVDDDPSIVELLRDFLENDRFEVKTANDAAEALIVFQRYPIHCIVLDIMMPGQNGFELCRRIRSESNVPILFLSARGDDVDKIRGLTLGGDDYIVKTASPGEVVARVKAVLRRTGSREEINRQVLDFGRLKLDLTIREVYVEGKPVSLTPREYELLRLFAEHPKYVFAYDQLLTKFWDGIGDKHTIRVHLSRLREKIEANPNRPAYLINVWGVGYRFEGVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRS5</accession>
    <name>A0A398CRS5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannose-1-phosphate guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04880">
        <property type="protein sequence ID" value="RIE04880"/>
        <property type="gene ID" value="D3H35_05300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="338" mass="37093" checksum="8843A01A1D80B109" modified="2018-12-05" version="1">MEVNSLKIVILAGGKGTRTWPRSNDELPKQFLPFLSKQTLIQETVNRFRDFVPPSRLFIALPRHYLPLLKEQLPDFPSNQLIVEPQQKDTAACIALTVFRFLQTKDDEPVAFVPSDQFIADKDAFLAAVSAAADVALLPDAIVTLGVRPDRAETGFGYLLTAPDSAAGKASSVSGIRRVDRFLEKPDEEQARLFMKEPDIFWNSGILICRPENMARCIQSFEPAIWNLLSQNPSNPDAAYAGMPRLSIDYAVMEKAKTIYCLPVNCGWDDIGSWGSLLRHLSSDPCGNVIHGEVDLMDASGNLVFMDNKKAVIIGLAALSSPLLPTVCSSALNTKSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRW4</accession>
    <name>A0A398CRW4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <shortName evidence="5">AGPR</shortName>
            <ecNumber evidence="5">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
            <shortName evidence="5">NAGSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">argC</name>
        <name evidence="8" type="ORF">D3H35_15185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02101">
        <property type="protein sequence ID" value="RIE02101"/>
        <property type="gene ID" value="D3H35_15185"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="4 5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="7">
        <location>
            <begin position="7"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="350" mass="38372" checksum="F4CABF8CD8C800D4" modified="2018-12-05" version="1">MNTPKLRAAIVGSTGYGGVELIRLLASHPYVDVTSVISSSSAGSPIAEGFPHLTEIRADKLDDVDPALVSEKADVVFLATPHGVSMKLAPQYLEAGLKVIDLSGDFRLKNIEEYRQWYKHEPASQADVDRAVYGMCEIFGDEVEGQSFISNPGCFVTSAVLALYPAVKAGWIDPDSIIIDAKTGVSGAGRGLNLSSHFSEINENFKAYKINKHQHTPEIEQSLARAAGRPVAVTFTTHLVPMTRGIMSTIYASQQERRSAADFVELYRQFYEGRKFVRIRPNGQWPATKEVWGSNYCDIGFNVDERTGRVTVISVIDNLVKGAAGQAIQNLNLVMGWDETLGLQFTPVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRW5</accession>
    <name>A0A398CRW5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4179 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_08340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03959">
        <property type="protein sequence ID" value="RIE03959"/>
        <property type="gene ID" value="D3H35_08340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025436">
        <property type="entry name" value="DUF4179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040680">
        <property type="entry name" value="DUF5643"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13786">
        <property type="entry name" value="DUF4179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18705">
        <property type="entry name" value="DUF5643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4179" evidence="2">
        <location>
            <begin position="59"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5643" evidence="3">
        <location>
            <begin position="231"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="456" mass="51266" checksum="42B80734ADE042FD" modified="2018-12-05" version="1">MKGRWNMNLTNLELELKRIGRAAMSEQEEMPDDVLERLEKTLTGLPDRSRRVEWRGRRAAIATGIVAAVITILCGFSMLSAPAAAALRQVPIIGSVFGQVGDYGLRLIYEGKTSTKVQLSDSHKGITFHVRDVLYDGTSLAFGYYFDGADEGISSSNIRMDVYVNGKKTDFRGFGYAMSELNGYIWHERPEQPDSLPEKFDLSLKVSRVGDVKGNWSVTVPVEEYKEGRLTLFPNVGKSSPDFSLLVRKVRFSPTMTAVDLDVQQAVMENIVLDYVLEDDQGVEYPPYESTWSTIIAPKQLNKTLETSLLFGPTGRIPKWIKIKPFLPSTDLGEETKAGMVSPPAPDQPIVLLQGEAGKMDILSVEYFRDRTRVHYRVQGKFPFFRASGLAIEDSGGNRVNRLPELVYVIEDLQKSEFFTDFPPIQEKDIRSFVTHRFAAPVYFPELDTIVPVDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS59</accession>
    <name>A0A398CS59_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1906 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02211">
        <property type="protein sequence ID" value="RIE02211"/>
        <property type="gene ID" value="D3H35_15850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015020">
        <property type="entry name" value="DUF1906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08924">
        <property type="entry name" value="DUF1906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="246" mass="26368" checksum="03703D28D318A9B4" modified="2018-12-05" version="1">MAKGIDCANPLTAKTAKSLAKSGFEFAGRYLVPAAYKWKRLTDAEAKVITDAGMQIVSVFETTASRPSGGASAGKLDGASAYKEAIGIGQTTGSAIYFAVDYDAQPGDYGHIEAYLKAAKAELPGYEVGVYGSYAVIEEMAKRKACGHFWQTYAWSGGKKSGHANIYQYKIDTTVNGLAVDLNESFGGEGWWSLNGEEESVMSEKDANKIIAFLQAGFNATESKEARDEFHRLANEVRKAAGMPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS84</accession>
    <name>A0A398CS84_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_00285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000003">
        <property type="protein sequence ID" value="RIE05465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05465">
        <property type="protein sequence ID" value="RIE05465"/>
        <property type="gene ID" value="D3H35_00285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="71" mass="7643" checksum="1412FF94F6F3DC60" modified="2018-12-05" version="1">MENGGELTNEREDSGAQASGAPRQGKKRGRKLLAIVIALLAIILVFLFFSLLLAKIQVINVEGASYLTAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSC0</accession>
    <name>A0A398CSC0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2062 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_00015</name>
        <name evidence="3" type="ORF">D3H35_08920</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000001">
        <property type="protein sequence ID" value="RIE05489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04139">
        <property type="protein sequence ID" value="RIE04139"/>
        <property type="gene ID" value="D3H35_08920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05489">
        <property type="protein sequence ID" value="RIE05489"/>
        <property type="gene ID" value="D3H35_00015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018639">
        <property type="entry name" value="DUF2062"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09835">
        <property type="entry name" value="DUF2062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2062" evidence="2">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="155" mass="17284" checksum="1DC99C448F62A6E8" modified="2018-12-05" version="1">MKYKYMMLIRAKGGASMVAMGFAIGIAVEMFTLPTLGFAFVLIFPLVYLFKGNLPAALVGFVVGKVIYLPMAILNTMVGAWVLPSHMSIHLPWMWVNKLLLANLKLIVGGVINGILLGAVCYYPIKLSIEAYKNKRREKRKLRHSTRLDTRPAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSF4</accession>
    <name>A0A398CSF4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cell division protein DivIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_00230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000003">
        <property type="protein sequence ID" value="RIE05462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05462">
        <property type="protein sequence ID" value="RIE05462"/>
        <property type="gene ID" value="D3H35_00230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013685">
        <property type="entry name" value="POTRA_FtsQ_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08478">
        <property type="entry name" value="POTRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="8">
        <location>
            <begin position="46"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE05462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="242" mass="26390" checksum="DF5DB4CDA0261837" modified="2018-12-05" version="1">MNERIPALKQAELPAKGKKRGRKLLAIVIALLAIILVFLFFRSSLAKIQVINVEGASYLTAEEVKAALAVNVGDSFFVPSSGKLETRVRSLKPVKEASIVKHFPGKLTVKLQEFEEVATELGADGKVQAVLANGLVLPSKQGALPDKPILTGWKTGDANFQALCQTLSQLPDHLLTDLSEIKPDPSKSYPDRIKLYTRSRFEVVTTVGKLSEKIIFLSDIVETASLDASFCSKTYFPYSANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSJ7</accession>
    <name>A0A398CSJ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_06260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04219">
        <property type="protein sequence ID" value="RIE04219"/>
        <property type="gene ID" value="D3H35_06260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006901">
        <property type="entry name" value="TrmK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04816">
        <property type="entry name" value="TrmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018637">
        <property type="entry name" value="TrmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="270" mass="29470" checksum="6E1614276F521DC0" modified="2018-12-05" version="1">MKETNAKQNGAGVKLSRRLSALAEWVPQGARFADIGTDHALLPVFLAGSGRISYAVAGDVHAGPADAARRQVAEAGLESLVSVRHGDGLSVLAPGEVDTVCIAGMGGSLIVRLLTEAGERLDGVRTLVLSPHVAEDQLRIWLRDKGFVLERELLLEEDGVIYTLLQATRGDSDDAKRANEALYDKSELGDCLSRLSDQLCYEMGPLLLRAPSSVFFAKWEQEASKREKIVAQMRKALAEDTTEKALEWEKAINDIREVLACLRAEKRSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSN0</accession>
    <name>A0A398CSN0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01964">
        <property type="protein sequence ID" value="RIE01964"/>
        <property type="gene ID" value="D3H35_14430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="130" mass="14565" checksum="10E3D6D4C7A6A188" modified="2018-12-05" version="1">MDSENQSPLRRRSQFIDAELPSSSFKTTYEWGSADGSGDPIRLTFRDYFEKFVYDQDFADAPNVSAGKLLGTGNTPSNILEVYPKASFVEYHYPGTDKNGGMDWKSLVVVFVPSGSDWKLVSIVHGQWTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSW4</accession>
    <name>A0A398CSW4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_14920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02054">
        <property type="protein sequence ID" value="RIE02054"/>
        <property type="gene ID" value="D3H35_14920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="109"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="294"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="451" mass="49157" checksum="12CDF56EE957956E" modified="2018-12-05" version="1">MGRSRECGLLVIGTLERERSVSRPAAANAGELAARWGLSPAQAEAAAAALNFLASPGRWLPPFSPDASVLSSLAGPGYSQLRPSSFTLQSLVAKRLANLLSSTFGRRNERSRLSGRTFLLWAVTGAGKTEMIFPLIDSVLASGGRVLIATPRRDVVLELAPRLSKAFPDAKRAVLYGGSADKFANAELTLATTHQLLRFQGAFDLVLIDELDAYPYHNNPMLHYAAAKAGKKAGATVLLSATPPAELKRQAVRGKLPHARVPVRHHGFPLPVPRRLPVPGAARWLQAAKPPHRLLKALAQSLDRGAQVFLFVPVIRFVEPLVELLRLHLRIRPDSIQGTSSEDEARTDKVDLFREKRIRLLVTTTILERGVTIPKSDVFVLDADKPLFDAAALEQMAGRAGRSRDDPAGRVYFAASSWTSAQRKACREIRGMNREAVRKGYLSANGRRGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSX5</accession>
    <name>A0A398CSX5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_17090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02421">
        <property type="protein sequence ID" value="RIE02421"/>
        <property type="gene ID" value="D3H35_17090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="73"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="278" mass="30568" checksum="A7A9821615C56E18" modified="2018-12-05" version="1">MRTVGSSRFGISLLYVFLALASLVAVFPLLWILLSSFKTSGEMASHPLAFFPETWTFDYYKRVMTNLNFGTNIKNSLIVSLSATVITIVISSLGAYGIVRFFPRTGKKMTKLLITTYMFPPILLAVPYTIIIIKLGLANSFTGLVITYLSFSVPYAVWMLIGFFQTVPMEIEEAAKVDGAGKLRVFLQVVLPVVSPGIVATAIYTFINAWNEFLFALLLINTSSKMPISVALYSLTGSEILDWGEMMAASVIVILPSVIFFMFIQKKIAGGLSDGSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTB8</accession>
    <name>A0A398CTB8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_07255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04499">
        <property type="protein sequence ID" value="RIE04499"/>
        <property type="gene ID" value="D3H35_07255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="300" mass="33043" checksum="1E3A8361D74FCD8E" modified="2018-12-05" version="1">MALNVHQLHIFYTVAERGTFSAAAQALHMTQPAVTMQVQALEERFGTKLLNRSTKKLMLTEAGHCLLPQARKAVELMRDTDTLMAKFVEDLKGRLKFGASLTIGEYVLPPMLGAFLRRYPDVSVSMKVMNTTDIIDAIGSQGLDFGLIEAPCDEPGFHTEPVMNDELVLVASAEHPFAAREEVELAEVIAQPLVLREQGSGTRQVMEDELLRHGVHGDSLRVVSDFGSTGAIKSAVEAGLGLSVLSEWAIKREIELGYLKKVRIRGVEFRRQFFAVRLKSALASMPAAALLQEIRGVSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTE0</accession>
    <name>A0A398CTE0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_00420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000005">
        <property type="protein sequence ID" value="RIE05430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05430">
        <property type="protein sequence ID" value="RIE05430"/>
        <property type="gene ID" value="D3H35_00420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="190"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="328" mass="38136" checksum="0EA485305B5F0CD5" modified="2018-12-05" version="1">MRLRIIIHSEGDSMNDALGDLHNMVPHFTQVIHRVVNGSWVNHRKVWDTHSFILVYDGEAVIGCNEEQRVGKGDLIYFKPGDVRWGYTFEDNPMKCYGMDFKYSCLLFDNDDWIKKDIPLPIQSFLHLNDSHLFSRVLHLFQNLTKEWISPTTFNKVSRERAYFMEILNLLFLWNSSKQSLNYDKIRKVEKVSQYILDNYSRKVKLQDLADYIQLSQSYLQVIFKDITGSSPIEYLINVRINKSKELMKEGYQNIGEISELVGFNDAFYFSRCFKRIEGITLLNTEVRFHRSANLSNISGSGLCPGLDIQTRLSHPGAALFGLLLHMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUI5</accession>
    <name>A0A398CUI5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03517">
        <property type="protein sequence ID" value="RIE03517"/>
        <property type="gene ID" value="D3H35_12050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="110" mass="12959" checksum="6D1A116950CB5A55" modified="2018-12-05" version="1">MAFGIRRQELQQWKDRVTRGEIAYLTHYWLDPRFPDSRTVTKVGCANVERLAAWCEENGLPSRYIHRRDAYPHFDLFGPKQAEVLLRAGEWEQLRRFGLLTEGKEGSEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUX6</accession>
    <name>A0A398CUX6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_02760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05069">
        <property type="protein sequence ID" value="RIE05069"/>
        <property type="gene ID" value="D3H35_02760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007742">
        <property type="entry name" value="NosD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032812">
        <property type="entry name" value="SbsA_Ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13205">
        <property type="entry name" value="Big_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05048">
        <property type="entry name" value="NosD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017281452" evidence="1">
        <location>
            <begin position="30"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="4">
        <location>
            <begin position="153"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="NosD" evidence="2">
        <location>
            <begin position="403"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Big_5" evidence="3">
        <location>
            <begin position="658"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1061" mass="112274" checksum="07F0FFAE9D45B2C6" modified="2018-12-05" version="1">MKKSINRFFAAFMVVMTIFAVLPQGFASAGNTGAGTTYYVSNDGDDGSAGSNAEPFKTLAKGVSQLQAGDTLVIKAGDYTEALVLNGLTGTAQAPITIRGEDGASITANAYVNAPFWKNFTISIINSQYVNISNVHFAFGDAPQSGDSYMAGISGTKHVNVHNNSFGDSGPAYAVFYLNTNNEKLVIDGNYVQGADNAFYGYGINDTTITNNIFTQWWTFHFESSTSKNNVISNNVFAGEGEHFYGGTYENSIITNNIFLGNPAISLGAGNTVGYNSVTSDSQKTSDKDVVATAADTFVSGSDYHLKEGSLSIDAGTDIGLPRYDRDGNERYGVADIGAYTHGMIYFVDANAAGGGDGLSEAAAFNNLADANAAIVPGATLLVKPGSYSGQIAITGTGASDTKSITIKKLGEGTVNINGGSSPAISLTDIANVTIEGLSLASTGNSALLANGVIDSKISGSTFTTAVHGIEITGNTRGSRFYNNTFKQADQKGILLKDSSNNQIYNNIFENYKNILNEGGSFTDTLIMNNVFVSRYGDGANIILKGTDTGNTIANNIFRAEGPAAIQAPASFYDAGAGNTVDYNLYDSTSAGLADGKPANETNSVYGNPLFASGSDYRLQLGSAAINRGTNTNAPEFDRDGSVRFGTTDIGAYEYAGDASAFYVISQSPQGSGLNVNSAIRIVLSEKTNDNNGNIASNVAVTTVVDGKTVAVSGSFSTADEGAGSAITFTPSANLNYDSTYTVTVKKDLMSANGNYLPADVVWNFSTAAFIMNEYYISSNGSDANLGTIDSPKRTVSSSLIAKLKAGDTVYFREGTYNGVIVLQAYTGTADKPITFKSYQNEKAVLTSDSPDYIIYLGHSQHIRIEGLTFAPNASQNGSRGTALRIDNHTAGSQPSSNITVTGNRFENTSTAIATRDLVNVGFGDFEISNNVIVSNDGWDCTSRRPRPRRAATAKSLTMSFTARRAALICGAKAPICCSTTTRSPTRTTPQAAAEDMTSIRCRARTTRLLIRSTFRRIWCSRTISLPSRFARSWKAANPLSTLRRTSYSTTMCTRLPARNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUZ4</accession>
    <name>A0A398CUZ4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_02865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05089">
        <property type="protein sequence ID" value="RIE05089"/>
        <property type="gene ID" value="D3H35_02865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="250" mass="26755" checksum="230DB8403ADAA80A" modified="2018-12-05" version="1">MQRFANLTTLVTGAGQGIGFAIAERFAAEGAHVLLADIKESTLIEAEEKLRAAGYSASRYAFDVSSPDQVDEAISRMIGERGEIHILANNAGIASEEPFVDIPDERWRRMIDVNLNGMFYVAQRVSRAMVRQGKGTIVNMASTNGLVGEAGYAHYNASKGGVVLLTKTMAIELGRSGIRVNAVCPGYIVTPLSASIDSEGVVERYVERYIPLGRTGKPEDVASVFAFLASDDAAFITGECIVVDGGQLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVS5</accession>
    <name>A0A398CVS5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_08435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03977">
        <property type="protein sequence ID" value="RIE03977"/>
        <property type="gene ID" value="D3H35_08435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="69"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="290" mass="32362" checksum="03DE9846033EA6B8" modified="2018-12-05" version="1">MRLRNSFKENMTGYLFIFPQILIFLVFLVYPILEGIRLSLYQINYQSEKFVGLDNYATLFNDPVFFKALVNTIVFVVFIVILTVGFALFVASAVFDKNAKYVSFIRGSYYIPVMVSMVVMSMVWSFLLNPANGLISYLSRESGMGTVNLLGNTQTVLPVIIFVTFATNVGQAIILYIAAMIGVPKDLFEAAEVDGASRWQVIRKILIPSVKPSTVYITIINIIAVLKIFVVIQLLTGGGPNNASVTLMYYLYNNAFKFNQLGTASAVGVIMFLITLLLSVPQLRSMIKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWS2</accession>
    <name>A0A398CWS2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">OMP decarboxylase</fullName>
            <shortName evidence="7">OMPDCase</shortName>
            <shortName evidence="7">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pyrF</name>
        <name evidence="10" type="ORF">D3H35_06655</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7 8">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the OMP decarboxylase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04287">
        <property type="protein sequence ID" value="RIE04287"/>
        <property type="gene ID" value="D3H35_06655"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01200_B">
        <property type="entry name" value="OMPdecase_type1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="PTHR32119:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7 8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="9">
        <location>
            <begin position="12"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="246" mass="25751" checksum="AF7CD6E6CA5A8CC6" modified="2018-12-05" version="1">MAQLTRDEAASKIMVALDKPDAEAALKLAGRLEGSGVWMKVGFELIYAAGPDIVRELKRRGMRVFLDAKMHDIPNTIRGGARSITRLGADMFNVHAAGGIAMMSAAIEGVREAVEAGDAEKAPIVIAVTQLTSTSQSTFNEEIGISGSIEDSVVHYAKTALKAGLQGVVASPLEVAAIKAACGTGFLTVTPGIRPRGVDAGDQSRITTPYDAVKGGTDYLVIGRAINAASDPREALDTILKEMTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWX8</accession>
    <name>A0A398CWX8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_06980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04337">
        <property type="protein sequence ID" value="RIE04337"/>
        <property type="gene ID" value="D3H35_06980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="217" mass="24909" checksum="BB00A880133D2977" modified="2018-12-05" version="1">MKDPLELWLTELLEKQEGERRTEKQSRILRAAVEVFAEKGYSGAATNEIAQRAGVAEGTIFRHYRTKKDLLYSIVAPFVAKLIEPFVLKDLYSVIDSPHETFEGFIRGMLENRIAFAEKNLKIIRILIQEVPFHDELREQFLNRVGEKVLQRLDNVVSHYREQGQIVELPSLTVVRLVASSLLGYLLVRFILAPKSGWDDSAEREATIQFILRGLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX76</accession>
    <name>A0A398CX76_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_02070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05178">
        <property type="protein sequence ID" value="RIE05178"/>
        <property type="gene ID" value="D3H35_02070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="177"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="4">
        <location>
            <begin position="393"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="650" mass="74727" checksum="A686A1BBD4E2695B" modified="2018-12-05" version="1">MNQNDHLRLWKTASIRVLDIRYTQMKKGEELRSYRLPASGFLYSVRGKARVILDGKMHDVEHYHVLHSGRGGCIDINRVGEEFEYYLILYKAALPLPIRHTLLELMEKSNPFQMQYVFAPSYPINLLDKVQKMYQEWNKQGELEHFHVKALFYQFVYELLRQQQDWEIHPFKPDLVDQAVYYIEENYNSPITLLSVAEKFNYSISYLGKQFKRKTGKSLIDYVIQIRMQKAQSMLLTIDATLQEIASRVGYADVSYFVRLFKKYSGITPSRFKTQYQNKRKVADYPIMRSNYANDWEWLWCYIDNEFHYHGKKKGDLSMVKVTKPSMLATLCLCFALLLSACSGGAATTNTGATEQSGASQAAATNPISNASETRIFVDDLGSEVEVPANPKRVVVATWHYPGHFLSLGITPIGVFENAKESKFIGDQVKDAELLTQESVEQTLALNPDLIITDSTNPNIDKLKEIAPTVVFDLTKRTNRLETLLDIGEIVGKVDEAQKQVANWENRLAITKKRFEEEFDSSQTVSVIGDYTKELYIYGPNFGRGTEVLYTSLGLKYPKILEDQLSKNDVRYVQLSEELLPDYLGDYVFISGPTEERKTILDDPLYATLPIVQNKRVYYIHEPSFYFSDPISLNGQLDFFERILLDGAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXQ9</accession>
    <name>A0A398CXQ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Glutamate synthase large subunit</fullName>
            <ecNumber evidence="17">1.4.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D3H35_09480</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="17"/>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03774">
        <property type="protein sequence ID" value="RIE03774"/>
        <property type="gene ID" value="D3H35_09480"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="16">
        <location>
            <begin position="24"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="910"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RIE03774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1534" mass="169252" checksum="96521D25ECD9F79B" modified="2018-12-05" version="1">MKEMIHGLPPKQGMYDPQYERDACGMGFVAHIKGRKSHEIVEQALTLLINMEHRGGQGSEPNSGDGAGIMLQIPHAFLSEEVSKLGFALPEEGQYAVGMVFFTQDEAVRREHEEKFAAIVEEEGQTLLGWRTVPTDDSTLGASAVRVKPYVRQAFIARAAALTDELAFERKLYVIRKRAEQAIRYSGIVGGESFYFSSLSSRKIVYKGMLTTEQVGHFYTELHDPKLVTAMALVHSRFSTNTFPSWERAHPFHYMIHNGEINTLRGNENWMHARQTLFASELFGDDLKKVTPVINDDLSDTGKFDNTFEFMYLAGRSLAHCAMMMVPEPWQNDELMDPDKKAFYEYHATLMEPWDGPAAMGFTDGVQIGAVLDRNGLRPARYYVTKDDIIIMASEAGVIELPPEDIVLKDRLRPGRMLLVDTKQGRIISDEELKKSIVSEHPYREWLDDHLVDLEDLPDALELPEPDHETVQQRQQAFGYSFEDVRKILEPMALTGGEPLASMGYDAPLAVLSERPQRLYNYFKQLFAQVTNPPIDAIREEIVTSTYTTVGPERNLLNPEPESCRHIRLYTPFLSNEEFAKLRHVHRPGFKSITLPIFFPADQGEEGLRQALKVLNEAADRVISKGHNILILSDRGVDEANAAIPALLAVSSLHHHLIRQGTRTKVSILLESGEPREVHHFALLLGYGVSAVNPYLAFETLDDLIRQGMLRNISHEKAVKNFIKAATKGVVKVLSKMGISTIQSYRGAQIFEAIGLNQAVIDEYFTGTPSRIEGVGLDVITAEALSAHNRAFSKQEGAVLELDSGGDYQWRKDGEEHLFNPQTIHTLQMATRTGNYETYKKYAALVQGEYENVRTLRSLLDFKLDQPPVPLEEVESVESIFKRFKTGAMSFGSISKEAHESLAIAMNRIGGKSNSGEGGEDPARYIPDANGDSRRSAIKQVASGRFGVTSYYLSNADEIQIKMAQGAKPGEGGQLMGRKVYPWVAEVRGTTPGVGLISPPPHHDIYSIEDLAELIHDLKNANPSARINVKLVSEVGVGTIAAGVAKGRADVILVSGYDGGTGASPIGSIRHAGLPWELGLAETHQTLIMNNLRDRVVVETDGKMMTGRDVAVAALLGAEEYGFSTAPLVVLGCIMMRVCQLDTCPVGVATQNPELRKKFMGEPEHAVNFMTFVAKELREIMAQLGFRTIEEMVGRVDRLDTKKALSHFKTQGLDLSALLHMPELPEGSARFNSKSQNHGLELSLDVQELVPAAAAALERQQPVEGKFEIKNTHRVVGTILGYEVTKRYGKEGLPEDTIKYHFVGTAGQSFGAFMPNGMTLTLEGDANDYVGKGLSGGKIVIYPSAKSKFQAEDNIIIGNTAFYGATSGEAYVRGVAGERFAVRNSGVNVVVEGVGDHGCEYMTGGRVVVLGRTGRNFAAGMSGGIAYVVDWDGQFVNRCNFEMVALERIEDASEIAEVRGMIEKHVAATGSELGQRVLNDWEGFLAKFVKVIPKDYKRMMEQIAKAESQGLSGQEALLAAFTANMRDLSRVGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXS1</accession>
    <name>A0A398CXS1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Intimin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Attaching and effacing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D3H35_08745</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the intimin/invasin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04031">
        <property type="protein sequence ID" value="RIE04031"/>
        <property type="gene ID" value="D3H35_08745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003344">
        <property type="entry name" value="Big_1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02369">
        <property type="entry name" value="Big_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00634">
        <property type="entry name" value="BID_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103647">
        <property type="entry name" value="SSF103647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51127">
        <property type="entry name" value="BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017399100" description="Intimin" evidence="8">
        <location>
            <begin position="50"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="domain" description="CBM21" evidence="11">
        <location>
            <begin position="46"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="CBM21" evidence="11">
        <location>
            <begin position="160"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Big-1" evidence="10">
        <location>
            <begin position="271"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="9">
        <location>
            <begin position="848"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="12">
        <location>
            <begin position="1436"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="12">
        <location>
            <begin position="1504"/>
            <end position="1569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE04031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1638" mass="177061" checksum="424CBBCE82B909C4" modified="2018-12-05" version="1">MVCEFVQSFAYSIEKLREIKTLKKITMWLLVCALLVSLAPSAFVGTAYAETNQVKLLFAKAAAGCQSACYEFSGAVEVNNVAYQKEVYIHYSTGNGQWSDIPATYAGKTEGNLEAWTFKKTINEPGKQIQFVVKYVVNGQTYWDNNNNQDYRIGGGSVPDRLLAKSYLALDEAGIGPSNSFSGRIYLKNVAYAKKVKIKYTTDNWATFQEREAAFAEMLPQSNNSLEYWDFQINIPPNTQELKYVVAFIANGVTYWDNNFNLNYTLGLPPQLTLTPSSASATAGTAVNLTVRASDKFGSPLKGFPVNVTSTGSAVVPAVVNTDANGQAQITVSNQKAETVVVTASLNGYSAKGTATVQFLPGQPASLVLQTDTPQIAVGQTVSIKAKLMDLNGNGVPNQTILWSRTGSVALPSTSVTDSKGETVVQASNSAAETATVTATSANGIKGTLQLTTRVPVAGIMLNKPSLKLQAGKQEQLTVIYTPSNSSNKKVVWSSSDPAIASVTQDGLVTAVSPGSATIKAVTEDGGYTAQSAVTVISADAIQAIERDNKIVHPNDQVGLHAVVANEGDIVSYAWSADKGTIAGTGGSVIWTAPEQYGFCEIAVTVTTSAGQTERKTIVINVVPLSDTTDPYGQLDPNEDTDGDVLMNSEEIALGTSPWSKDTDHDGLSDSREVQLHTNPCAKDTDGDGVYDGAEASLGTNPLTADIPANKKFTVNLALDNSNAASATVTGAGNLYYNTLRVSDNPLFASFKNVIGTPVVLTSSEHADKAVIKFRYETAELAAKGISAQDLLVYKFDNDRKVFVKLPQSAVDTANRWVTAEDNDVFDPKTVYAAASSSLSVNATKAFDVVYALDMTQSLYDRDPGFASKDGLRNTLAELPEGSSVSIVRANPAIETLEQDSGDKELLGYTFEDAQYKPDPGTGDLGALVGKGIQLLSGGSSAKGKVLIVLSAAYNAADRTALTAQIKAARSQGIVVYVTGYSNSPEDYGGIEQLAAAGAGKAAVAANPGSYDIALGELKNDFSFFVPAAAQAGISPPLNMFTRTVKGFDISKHGFKFINFAVGPYGTLSAHSAGFAAAAAMNFAGLLPSSVEINAFEKSLDDKNEPFSFNGQSTAYDLFADGDILQTNNREIAKLDPTESVKKLIAFWWLRGMGEMTAYSDLFNRNDASKSVKSDGFNYLSSNDVDFITDQLDAGYPVYIDFGQSYENASKANELTHTYHPVLIYGYNKQSRNGQPVRIDLQAYDSNHKLDPTRAITLDRLTDGSKLKDEWKYEYDLAYNGTSVYSSDKTYDGNKVTYRRFLVFDMRKYKETFDRQYDSSKNTKATITETRSATELWGSRTGVQTVIKLTVPKEKKDEWTIIHFAGQKGTEVKHEFTATETPKGDFIEYTLKSFNIYNQLAVKVKTEFVEIDASSQSPATGKVNMQDNYPDAFLFPSNNFGDVSGNMWFAREVKTAKFLGIASGYADGLFHPANGITKAELITMAMKASETEARWEGDYSLAKAEADKYTDLTNHWAWRNIGLALARGWVEPGDAAGGLFKPNEEVTREEAAYLLWTIMSSTQANGIKPLIQNNAATPPYSDIGAIQTKYQSAVTLLNLNNIAQGKVYYSSGQLVNKFEPLSHLTRAESCKWIVDFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYF1</accession>
    <name>A0A398CYF1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3'-5' exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04024">
        <property type="protein sequence ID" value="RIE04024"/>
        <property type="gene ID" value="D3H35_08710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="202" mass="22771" checksum="9BE12867CDCFF553" modified="2018-12-05" version="1">MKLPDITVLDFETSGLKPAADRVIEIAAIRVSGGEITTQFSTLVRFDGYLPAKVTELTGLTSAQLAKGMDEETAFRILNRVIGDSVIVAHNALFDLSFLHHTLLRLAGRSFRNSFIDTLTISRTRHAYPHTLTDMSKRYGIELNGAHRALADVVACWQLLEKLNEEQSVEPDMNRIGYLRKYGKPEWYPEQAKMESIELKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYN0</accession>
    <name>A0A398CYN0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YheC/YheD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_03395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000019">
        <property type="protein sequence ID" value="RIE04937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04937">
        <property type="protein sequence ID" value="RIE04937"/>
        <property type="gene ID" value="D3H35_03395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026838">
        <property type="entry name" value="YheC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38437">
        <property type="entry name" value="PTHR38437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14398">
        <property type="entry name" value="ATPgrasp_YheCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="216"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="456" mass="50284" checksum="806AE6C40570C6D9" modified="2018-12-05" version="1">MSTPKVNVQIVSSDILSDDVLMLGESVMKQLKIPAHQPISLKFGAFRHSVTLVPVPRFEGMRMSQTLSHRMGIHSGTPLRLQYRTSGRTLALGPLIGVLVSRSFPHIPDKPFGDITLFCRELTTACRAQGAYVYFFTPGGIGSSSNSVEGWVHNATGWHRMSLPAPDVVNNRLTTRKLENSAVVQSFMKDIRNRYGSHVFNEKFLDKSEVFEALKKDSAVQKYLPESYSLRSYAMFKSMCTRYSAVFLKPVRGSLGKGIIRLTRVGSESWQASYATVNGTRRQSFNDPAKLFSSISGKMKTVRYLIQQGLTLIEAGGRPVDFRALTQKNASGAWQITSIVGRTAGSHHFVSNLARGGTLSTVKEAVAKSNLPGTHRAVASSRLQRAALDIAKGIDEKIPAHFGELGIDLAIDTSGRVWLLEVNSKPSKNDNTPLKEGKIRPSVRMMIQYARHLSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYT3</accession>
    <name>A0A398CYT3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Primosomal protein N'</fullName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">priA</name>
        <name evidence="11" type="ORF">D3H35_07330</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04391">
        <property type="protein sequence ID" value="RIE04391"/>
        <property type="gene ID" value="D3H35_07330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041236">
        <property type="entry name" value="PriA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040498">
        <property type="entry name" value="PriA_CRR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18074">
        <property type="entry name" value="PriA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18319">
        <property type="entry name" value="PriA_CRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00595">
        <property type="entry name" value="priA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="290"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="550"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE04391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="824" mass="90578" checksum="FC668EB6D62E1A10" modified="2018-12-05" version="1">MTIARVIVDVPSRETDRPFDYSVPDSLRDWVEVGSRVAVPFAGRTLQGIVVALPGDAEVELSRLKAVSDVLDAVPPLSEELVKLGEWMSRRWLCPLTVAFQAMLPAALKGRTEKYVSVADDAVFSDEELAEAGALLHALRKDSATQAKLSALLTKFQGSGAHLKRWLKQGRLIERQKVENRLSVKTVLTVFPRDADTLGAGKADIPARARKQREVIEWLEEHPEPIALQELAEAAGTTASTIRSLEERGLLEIRGVTEDRDPYADRDFPVSSPLPLTPAQATALEPIASAIDAKDRKVFLLHGVTGSGKTEIYLQAIQQALSLGREAIVLVPEIALTPQMVERFKSRFGARVAVLHSRLSQGERFDEWRKIREGRAQVAVGARSAVFAPFSNIGLIVIDEEHETSYKQEESPKYHARDVAIERARLSGAAVVLGSATPSLETYEAALSGRAGPDIPHYISLPERVADRPLPGVTIVDMREELKLGNRAMFSRELADALRDRLAKGEQTVLLLNRRGYATFVMCRSCGHTVQCPHCDISLTHHKGSGNMRCHYCGYAETEPKTCPACQSPHIRFFGTGTQKVEESLAHTFPGIRVIRMDVDTTSEKGSHEKWLTEFRERRADVLLGTQMVAKGLDFPYVTLVGVLAADAALRLPDFRAAERTFQLLTQVAGRAGRHELPGEVIIQTYDPEHSSVASVQGHDYAKFTEQELFIRSQLGYPPYGRLIALTFSHESVPMLLSVGQRFASGLKAKAAELGLASTELDVLGPVPSPIPRLKDRYRFQCMVKYRGELAASALVAGVLQGMGEAVKKSGVLTSVDVDPQMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZD4</accession>
    <name>A0A398CZD4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbon-phosphorus lyase complex subunit PhnJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05217">
        <property type="protein sequence ID" value="RIE05217"/>
        <property type="gene ID" value="D3H35_01470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019700">
        <property type="term" value="P:organic phosphonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010306">
        <property type="entry name" value="PhnJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06007">
        <property type="entry name" value="PhnJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011468">
        <property type="entry name" value="PhnJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00379">
        <property type="entry name" value="Phosphonate_metabolism_(PhnJ)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="283" mass="31887" checksum="92DD402AABAEFAA8" modified="2018-12-05" version="1">MPTHYNFAFFDEGSKREIRRATLKAIAIPGFQVPFASREMPIGRGWGTGGLQLTLSLIGKNDTLKVIDQGADESVNAVSIKKLIGKTTGVLTVDETDRATLIQSRHRVPEVPLRAGQILVLQVPMPEPLRPYEPSELETKRLHGEKEYSGAWLMLFEQIMKYRSVSTGADHPVMVHDRYVMAPSPIPKFDNPKLDRSEALILLGAGREKKIYAVPPYTRVVSLAFEDVPFEPETFRDHACKLCGATEVFMDELYDEEADAAYFQCNDTSNCLDRRNRQQSQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZL2</accession>
    <name>A0A398CZL2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04364">
        <property type="protein sequence ID" value="RIE04364"/>
        <property type="gene ID" value="D3H35_07160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="523"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="650" mass="72879" checksum="BC65C3EAEDDF7D44" modified="2018-12-05" version="1">MQGSNNETSARSPVWSVSRQHLPSWLAEQDLTEADLPYIQPLLTDAFLDWLGESDGFPWLRGRLSIVQPSGKTVIQHGDGWFPESWDAKLIGTTAVSEALDRMEPALINSDKHASSFLRSSDSIAVPIFTRIKGVAFGVVVCLLPAGTAKQEELSLLQAAALHYRSCVYRRFESMFVNGMLSEQKQSRREQRRRDILFEVMRRLNGHIDVENVLSEVLDSLEKLYPFCRADLFLSQDYSSANEKVKPLAFHELDMDLCRHAFLDGQVREERAGGRHLVAMPLTGKQGVYGVLRLDTPENNFDDDDLRFLTMLAGTAGAAFEKAKLHEHANVLIGELRIINELTQQLNRSLRLTDTMQFASAELLHIFNADYCCILQLDASNNEFVIMAANVPELIGETFSSDYGFCGVIWDTKEPIILSDYRSATPVTSMFMEVTSSRSLLASPLLLNGNIIGAVLIGKQHANHFSYENYKLLQVLSTHLGLAMSNASLHAEVRRMVITDNLTGLFARHYLNERIGRKLKKDASGSLILVDIDHFKRINDTYGHQVGDSILIQVSNIIRSSIREGDIAARWGGEELAIYLPQLGLEQTGRVAERIRERVELETDPQVTVSCGISEWHSSDDKISVESLFYRADMALYEAKNNGRNRVEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D032</accession>
    <name>A0A398D032_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000002">
        <property type="protein sequence ID" value="RIE05477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05477">
        <property type="protein sequence ID" value="RIE05477"/>
        <property type="gene ID" value="D3H35_00165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="68" mass="7123" checksum="99A78539E46EC6C3" modified="2018-12-05" version="1">MRPILMTAIATVCAMLPLVFGTSESGSIVSQSLAIVVIGGLIVATLLTLVIVRAFTSCYFFRKSNASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0I6</accession>
    <name>A0A398D0I6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplX</name>
        <name evidence="6" type="ORF">D3H35_02295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="3">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05001">
        <property type="protein sequence ID" value="RIE05001"/>
        <property type="gene ID" value="D3H35_02295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE05001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="117" mass="13084" checksum="B526293704A4FFEF" modified="2018-12-05" version="1">MPRVKKVLESHNNKLHVKKDDNVLVITGKDKGKKGRIIAAYPRENRVLVEGVNMVKRHTRPNPANPQGGIIEREAPIHVSNVMHIDPKSGKPTRIGYKVLDNGTKVRVAKRSGQEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1H0</accession>
    <name>A0A398D1H0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spore gernimation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_02425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05024">
        <property type="protein sequence ID" value="RIE05024"/>
        <property type="gene ID" value="D3H35_02425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041262">
        <property type="entry name" value="GerD_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17898">
        <property type="entry name" value="GerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017275921" evidence="2">
        <location>
            <begin position="29"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="GerD" evidence="3">
        <location>
            <begin position="76"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="222" mass="24308" checksum="EF4B425AA1C663F7" modified="2018-12-05" version="1">MRRYRLPALGAVIGLTFTLVSCGPESSGSGDNQMSYKEVKSMVIDILGSQEAQQALEKAQSAQYGESTLHMKGLTVQDQEQVRIAVKDILTSPDYSKVLETIMKNPKFAGEFAKAVSSDNKQIHKDLMKDPTYQSELVSTFKTPEMQRILFDAMKSTEYRKQIQASVSESIQNPLFKLEIMKLLQTVVKEELTPTAKESGKKEGGQEGEGGKSNDSGGSSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1Z1</accession>
    <name>A0A398D1Z1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_03080</name>
        <name evidence="2" type="ORF">D3H35_03095</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05124">
        <property type="protein sequence ID" value="RIE05124"/>
        <property type="gene ID" value="D3H35_03080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05125">
        <property type="protein sequence ID" value="RIE05125"/>
        <property type="gene ID" value="D3H35_03095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="72" mass="8465" checksum="DB25321AC3E20859" modified="2018-12-05" version="1">MLHTTISYGLDDTELAEYEAENKGYRKDVFVKIQDDYYNLRTENIKEIICLLYDDGYFKHLKPVDKGVHGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CAZ5</accession>
    <name>A0A398CAZ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000059">
        <property type="protein sequence ID" value="RIE00316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00316">
        <property type="protein sequence ID" value="RIE00316"/>
        <property type="gene ID" value="D3H35_29300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="101" mass="11593" checksum="05D88B4794A25D93" modified="2018-12-05" version="1">MKSFIKVLKMIIESFIRVYKVSPFSVLLMLLVSLTGAFYSYANIYFSKLLLNSIVEMNKNIITLSICSIAGFQLIKLIIDFISSLQTVKLSIRFSKKVMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBH2</accession>
    <name>A0A398CBH2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_28090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000053">
        <property type="protein sequence ID" value="RIE00506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00506">
        <property type="protein sequence ID" value="RIE00506"/>
        <property type="gene ID" value="D3H35_28090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="69" mass="8259" checksum="E3885AC527828F51" modified="2018-12-05" version="1">MNLFRKCLYFGSNCARRFQAAFALRVYRFFRMRAEIEQYLDELRSVSEPGSVRWRDSNHSKSSTAVFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBP6</accession>
    <name>A0A398CBP6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_29640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00203">
        <property type="protein sequence ID" value="RIE00203"/>
        <property type="gene ID" value="D3H35_29640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017180533" evidence="1">
        <location>
            <begin position="23"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="2">
        <location>
            <begin position="41"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="2">
        <location>
            <begin position="64"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="220" mass="23835" checksum="C45DDEAC0879E826" modified="2018-12-05" version="1">MKKKWAAAAISAALFLCTGAGAYAGANLQEIKAYLNSGIKIKVDGKPVKLQDAQGNPVIPITYNNTTYLPVRAVSDALKIAVDWDGSTSTVLLGEKVDGVSIDTGEQLSIHTTLDPTFTTYNGKNYKAAITYQGNDSIVLYPKKKYQKLYLQIAAIDKDVDIEFKDSDTFRTLKETTTIKANSGLNTIEVDIGGIDTIWAGVTAKEGGTFFIPLTTSYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CC73</accession>
    <name>A0A398CC73_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D3H35_28555</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00373">
        <property type="protein sequence ID" value="RIE00373"/>
        <property type="gene ID" value="D3H35_28555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="307"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="466"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE00373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="593" mass="67799" checksum="95E035249254A422" modified="2018-12-05" version="1">MLSYFVVILLSIALVGTVSFYISYKTMADRAESAGLQLVRQIENNMDNDFHSKRNLLLAPYNDQAYIDGINRYADMSDQEKFLFRQRIGDLYLKSFNVTPIRDFLRFQIYYGDGELLSSSDARKPWTPSQVRNSEWFRSTVAKDGEAFFSGFIPQEANEPSEVAAYASSIMIRDFSNPDRFIVVRTEYRSSLFRSIGQNDDLSLNSRIVILDEDNRLVYESGNESKSIAESELLERAVGREGKFWINVGGEEMLASFTSSGYSNWKAVLVTPRVEIFGALDKIKTTVIFTAIIAFVFTFMISVLFGQRITRPILNLYKTVNRIKRGDFSLRVKIDRNDEIGRIGMNFNAMQDELQTLIETKYLNQIKLQEVELAMLYSQINPHFLYNTLDSIRAMSDYYKVEEISVMAQSLADMFRYNTKNKDEIVTLQEELDQIDSYIKIQSIRFEGKIECGIQIDEALYGTPLLKMTLQPLVENAVFHGIERKRGKGMITISASKERSRIRLSIKDDGVGISEKRLAEIRDKLKPPAQQLIEPSAEREIGIGIVNVYSRYAIRFGDRFDFTIDSKKGSGTEITLVFPPFETESDAKSESST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CC95</accession>
    <name>A0A398CC95_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">add</name>
        <name evidence="4" type="ORF">D3H35_26720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00786">
        <property type="protein sequence ID" value="RIE00786"/>
        <property type="gene ID" value="D3H35_26720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01320">
        <property type="entry name" value="ADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="PTHR11409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A_deaminase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="340" mass="37974" checksum="4B747F65BC04419C" modified="2018-12-05" version="1">MVRDDSLRFLPKVDLHLHLDGCVSPDTLAELAAQENVPLPAKDRAGLLPYMQVKDDCVSLKDYLTKFDFVLPLLQTGEALERVAYETVEQAARQRTMYLEVRFAPQLHRLRGMSAEETIGHVIGGLRRGEKDFGVKSRVIAICMRHHPERLNLEVIEAASAYLGKGLGAVDLAGDEASFPAHRFRSVFTLANRKSIPVTIHAGEAAGPANIREAVNRLGAARIGHGVRLREDPDLRSAIRNSRIPLELCPTSNLQTKAVSRWDDYPIRDYFEDGILVTVNTDNPTVSGTDMTTEYRILRERFGFTLRELGQLTLNGVEAAFLEPNEKKLLKKEIEQALPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD76</accession>
    <name>A0A398CD76_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01136">
        <property type="protein sequence ID" value="RIE01136"/>
        <property type="gene ID" value="D3H35_22245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="55"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="307" mass="34760" checksum="9767CBA48B472A6A" modified="2018-12-05" version="1">MIPECLSAYRLFMPMLDEVAEWSLLRQWSLSEVYRAILKTGETRIIKWGGKEMAGEAVIYRQLVSQLQIKAPEIFEFFEANGSTVMVMEDAGKYNLEQQPYPRYFLEAARELANLRATAAANLARNIPGRVIRSHTVSVEDFLALLDDLLQSPCLSERIALAKLKNTFPYDLAKLYRTSPLTLVHHDYQAKNLLVQADGILPIDWSIAYLSPHLGDLYCLIADARTWSGVSREEILSAFLSEAGNDLSIEQLNWHIRIGGLCWLVKTLRWLVYGGTAAIPGSDAWIPDLMNQVEKLVKEAEEEGERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD87</accession>
    <name>A0A398CD87_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01146">
        <property type="protein sequence ID" value="RIE01146"/>
        <property type="gene ID" value="D3H35_22320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="169" mass="18730" checksum="964433F5E6E28A01" modified="2018-12-05" version="1">MGSKVIIEQLQSIEESSAELSELLIQVVEDGASIGFLPPLSPADSEQYWGNVISPEAILFVAKLNERIVGSVQLHLCTKQNGSHRAEIAKLMTHPGYRRKGIGRLLMQEAEKRAEREGRSLLVLDTREGDPSNILYGSLGYIQAGRLPNYAQSSNGELHATIFYFKYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDR1</accession>
    <name>A0A398CDR1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="10">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">dusB</name>
        <name evidence="14" type="ORF">D3H35_23415</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:54452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23624"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dus family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01326">
        <property type="protein sequence ID" value="RIE01326"/>
        <property type="gene ID" value="D3H35_23415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004652">
        <property type="entry name" value="tRNA_dU_NifR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00737">
        <property type="entry name" value="nifR3_yhdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="13">
        <location>
            <begin position="15"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE01326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="350" mass="38460" checksum="AD2233C88D616F5F" modified="2018-12-05" version="1">MLKIGNIEMPNNVVLAPMAGVCNPAFRLIAKEFGCGLVCAEMVSDKAILHGNQRTLEMLFVDEREKPLSLQIFGGDKESLVAAAQYVDKNTNADIIDINMGCPVPKVTKCDAGARWLLDPNKIYDMVSAVTDVVDKPVTVKMRIGWDSEHIYAVENARAVERAGGAAVSVHGRTREQLYTGKANWDIIRDVKQAVNIPVIGNGDVVTPEDAKRLLEHTGCDGVMIGRGALGNPWMLYRTVHYLTRGEMLPDPSPAEKIRIAMLHLDRLANLKGENQAVREMRKHMAWYLKGMPGAARVKDSLMELTARSAVEAALRDYVYSLEELRASEEREAAEGGNSEGAEPGEVLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDZ6</accession>
    <name>A0A398CDZ6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MMPL family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_25535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00933">
        <property type="protein sequence ID" value="RIE00933"/>
        <property type="gene ID" value="D3H35_25535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="648"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="727"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="255"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="587"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE00933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="787" mass="82443" checksum="716008E62D503D78" modified="2018-12-05" version="1">MSKLLYRIGKAAFDKPWAFIAAWILIIGIVVAMLGVNGMSVSSEMKIEGTESQKVLDKLEKELPEASGGQASVLFTAPQGERLDTPERIAAISRAVNKVYGLDYIINPSELAAAAGAELSAEQAAQKDASAETAQDGQPAGAAQGTDATSAANAAGGEMPPYTQLMIDGQPVPGVLIATDGSIALLQFQFTVQQNSLPQGVTDKVVDAVTESVDGSGVIALPSDSLKATEVPIGINEVFGLLIAAIVLVMTLGSLVAAGLPIITALFGVGIGVGGAFALSTFVTMTSFTPVLALMIGLAVGIDYALFIVNRQRRLIFDQGLTAREAAGRAVGTAGSAVFFAGLTVIIALFGLLVIGISFLSMMALVASVTVFLSVLIALTLLPALLGLLGERICSAKAREKHRLKAASKQHGFADVWVKAIVKFRWLVIIAVIAVLGVAAIPAVKMEMGIPSGASANLDTSARQSYDAISAGFGKGFNGPLLIVAESNNSAGVIAPETLGGIVQEIQKNKHVSVVTPLGMNANGNIAIFSLIPTTGPTDTDTKDLVKELRSADSAIAKNYGVTLGVTGLTAINIDMSAKLSEVFPTYIGIIMVLSLIILLLVFRSILVPLKATVGFLLSILATFGITTAVFQWGWASSLFGVDTGGPLMSFIPILVTGILYGLAMDYQVFLVSSMRESYVHGHRGRSSVIHGYDQASRVVVAAAVIMVAVFAGFVMTHDIMIKQIGFALALGILIDAFFVRMALVPAVMALFGDKAWWLPKWLDRLLPNLDVEGDKLIAELQAKEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEK6</accession>
    <name>A0A398CEK6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01143">
        <property type="protein sequence ID" value="RIE01143"/>
        <property type="gene ID" value="D3H35_22305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029441">
        <property type="entry name" value="Cass2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14526">
        <property type="entry name" value="Cass2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="287" mass="33277" checksum="06D4B2969DA5C113" modified="2018-12-05" version="1">MNDYTRVQNAIEFIENRLHEDVDMKEIAAQACFSAFHFQRLFHLITGFTVHEYIRKRRLSEAAKVVKETNGSLLDIALSCRYGSHEAFTRSFAGFFGVTPAEYRKNDYRLNMQNKVDFRDYSGRANEETKLRKPDLVRLEPMKIVGHEYKTSLNNGSYFADIPGFYDHFGVNGYYERITDRAKPDFPYGIGAYYEDNGDFSFIIGEEVHSFGNRETGFVHFEIPGGTYAEFKANGAPEFNQSLWRYIYGTWLPNSNYERREGPDFEVTDVRHSVPGCLAMKIYIPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEY2</accession>
    <name>A0A398CEY2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2277 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01130">
        <property type="protein sequence ID" value="RIE01130"/>
        <property type="gene ID" value="D3H35_22210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018735">
        <property type="entry name" value="DUF2277"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10041">
        <property type="entry name" value="DUF2277"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="90" mass="10108" checksum="7A944AFF8010465C" modified="2018-12-05" version="1">MCRNIKTLFNFEPPATEEEVRAASLQFVRKLSGFNEPSKANGEAFELAVQEVAEAARKLLDSLVTQAPSRNREIEIERARAKSIKRFGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFA3</accession>
    <name>A0A398CFA3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation peptidase YabG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yabG</name>
        <name evidence="1" type="ORF">D3H35_23835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01403">
        <property type="protein sequence ID" value="RIE01403"/>
        <property type="gene ID" value="D3H35_23835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008764">
        <property type="entry name" value="Peptidase_U57"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05582">
        <property type="entry name" value="Peptidase_U57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011575">
        <property type="entry name" value="YabG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02855">
        <property type="entry name" value="spore_yabG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="298" mass="32970" checksum="A7E2C2F0EC9C67A3" modified="2018-12-05" version="1">MKQGDLVVRKSYGGDMLFRIAAVGGKDALLRGMDYRLLADAPIQDLQAVRYPDELGGTRTARIHTNESLRRMREERVRTASLSRQPNDSDYRRQPFFELPGKVLHLDGDANYLKKSMQVYNQLHVPAEGAHCLESQMPLVLQRLLPHVRPDIVVITGHDGVLKQREDLQHIGSYKNSLNFVHSVNVAREYERNRDSLVVVAGACQSHFEALLQAGANFASSPGRIMIHALDPVYVAVRAAFTPFRETINIADVIAHTISGMQGVGGIETVGKYRIGVPNMKPPTIAPSTITGSNVNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFC7</accession>
    <name>A0A398CFC7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_22115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01115">
        <property type="protein sequence ID" value="RIE01115"/>
        <property type="gene ID" value="D3H35_22115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="7"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="361"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="404"/>
            <end position="411"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="677" mass="74286" checksum="0CA9766FDC56A178" modified="2018-12-05" version="1">MEQLLDIQELSVDFHTRRGLLQALTDVSLTILPGETVCLVGESGSGKTLTSKAVMRLLDYENGRISKGRIRFGGHDMTTLSQQELRLLRGKKMAMVFQEPMAAFDPVYTIGHQIVETIRVHDAKTKAEAWMHAVSLLERVGIPEPRIRMKQYPGELSGGMLQRAMIALALSCGPELLIADEPTTALDVTIQAQILQLLQELKEEFGMAILLITHDLGIAAEIADRVVVMYAGRVVEQAPTEELFTAPRHPYTQGLLRSIASLDTKKGEKLHAIEGTIPSLSALPAGCLFHPRCPYATDQCRSEAPPLVSEGDRKAACWHSDRVIEAAWRVPDTQAAAIVDTESARSAVDESGEDAPAPDLIEVNGVSKFYPVKGRLPGRTRTFIRAVDDVSFTIRKGETFGLVGESGSGKSTLGRVLLQLERATEGTISFQGRELTTLGGSALRGARREMQMIFQDPYGSLDPRWSVGDIIAEPLRTHEKPSARESQERVAELLGAVGLDASYAKRHPHELSGGQRQRVGIARAIALNPRFVLADEAVSALDVSVQAQVVNLMQELQAKLGLTYLFIAHGLQIVRHISDRIGVMYLGKLVEIAPSHELFLRPAHPYTQALIASIPLPDPSRRWERTTLQGEIPSPMRPPSGCRFHTRCPFAAAKCREEEPKLAVIGKDHVAACHYPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFN9</accession>
    <name>A0A398CFN9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05335</name>
        <name evidence="1" type="ORF">D3H35_22910</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000024">
        <property type="protein sequence ID" value="RIE04589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01245">
        <property type="protein sequence ID" value="RIE01245"/>
        <property type="gene ID" value="D3H35_22910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04589">
        <property type="protein sequence ID" value="RIE04589"/>
        <property type="gene ID" value="D3H35_05335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="257" mass="28221" checksum="DF2941B10996F16D" modified="2018-12-05" version="1">MQGVIMRIVITGGTSGIGYGTARLAAERGWKVTIVGRNRAQGAKITAELGVDYLHADLSKMSDVRRLAEQIEGPINALALCAGGISTDKEVRLTNEGLETTFATNYLSKFALSEMLLQQNKIVPDGCIVMVGGNGVHKNASTVWAEPQAGLQAAMKAAFAVDLYASELAKRHPRLRVHTCYPGMVRTNLFQEAPLLFRLLSRIFGQPIAKGSAYLGRLILENHSGVHWKQDRPMRFRVPLPEGQEAEALWAYSRQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG08</accession>
    <name>A0A398CG08_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exodeoxyribonuclease III</fullName>
            <ecNumber evidence="4">3.1.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">xth</name>
        <name evidence="4" type="ORF">D3H35_21995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01653">
        <property type="protein sequence ID" value="RIE01653"/>
        <property type="gene ID" value="D3H35_21995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="PTHR22748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00727">
        <property type="entry name" value="AP_NUCLEASE_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="251" mass="29049" checksum="005659F1CF49EC3C" modified="2018-12-05" version="1">MKLVSWNVNGLRSCVNKGFVDYFEATDADIVCVQETKLQDGQIKLELGDSYSQYWNYAVKKGYSGTAVFTRIKPLSVRYGMEEDEEPEGRIVTLEFDAFYLVNVYTPNARRDLSRLEYRLEWEERFKSYLLQLDALKPVIACGDLNVAHREIDLKNWRGNRGNSGFTDEERDKMTRLLDAGFVDTFRHLYPDRTDAYTWWSNMPGVRERNVGWRIDYFIASSRLVPSVIDARIDAEIRGSDHCPIGLTVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG91</accession>
    <name>A0A398CG91_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">M23 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_24280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01475">
        <property type="protein sequence ID" value="RIE01475"/>
        <property type="gene ID" value="D3H35_24280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51109">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="246"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="G5" evidence="3">
        <location>
            <begin position="297"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="503" mass="54716" checksum="80C608E20514A4C1" modified="2018-12-05" version="1">MAVFRGTGRMKNGWNALQQKIRNNRSLSLNLRIYSVPIAVTAIAFAAIGGVAALGHQYVQANSVDYYRVMLEGKPIGAISSKDKVEQLLSAKEAELRKADTPVLAALDEDQVSYEPERAYKIETDDEATLVRLEGMLKVHAVGVKIVVDGKDVGTVRDQKTADALLQRIKNKFAPQQTAKKSVPEVQSLSVKTTATAKAAATPQRTITSVKFVEDIDTKEVAIGGTPPSDPDKLFEKLLTGNPAPITYTVKEGDCVGCIAEKLGVSTDLIYEKNPWIKDDEIDVGDELDLTALTPLINVETVEQITQVEPIEATVEYQKSDDMRAGQTKVLRQGTDGQRQVTYRLVKQNGSTLEEEIVSQQVLKPAVSTIILKGTKVILGEGTGKFSWPVIGHRITSYQGTRWGRMHKGIDIIGKSSILAADNGVIEFAGYKSGGLGNAVIINHKNGYRTVYGHMKSVNVKKGQVVQKGDTIGIMGSTGHSTGTHLHFEIYLNGKLKNPTSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGC4</accession>
    <name>A0A398CGC4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01002">
        <property type="protein sequence ID" value="RIE01002"/>
        <property type="gene ID" value="D3H35_21340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="132" mass="14690" checksum="7DF3F4579D089DF9" modified="2018-12-05" version="1">MKEESSRLRKLLSQEGAPGRILELIVKEQVESHIRKGSYLRIVQIVLSQPAVFDKQSKAVFAYSSEIVTALTRLIEQGQAAGELLPGDPEATGWSYFSYVSGLGMINHDADDNLVREFVDRGCRIIGLLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGS3</accession>
    <name>A0A398CGS3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_14310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01943">
        <property type="protein sequence ID" value="RIE01943"/>
        <property type="gene ID" value="D3H35_14310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="298" mass="32969" checksum="8ABB6F5C5B0DA2CA" modified="2018-12-05" version="1">MDQALKVFVMVADTRHFSHAAEKLHMTQPAVSQQIRTLEQRFNVRLLERNNKSVSLTKAGEIVLHHAREIAGLYRRMEEMVDELVHYTGGPLSIGASYTFGEYVLPKALARLSVDYPDIQPAITIGNTSDIAQKVRNRELDVGIVEGEEIGSGLEVERLSEDAMYIAVGAGHPLANTASVAPERLSEQTWLVREIGSGTRAATEGMFAEFGIHPKRLMEMGSTQSIKETVEAGLGLTLQSNLCLRKELGLGTLKLLDVAGLPVRRNFHILIRVGDLRTRTLDVFLEALRLVTAEMNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH32</accession>
    <name>A0A398CH32_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02516">
        <property type="protein sequence ID" value="RIE02516"/>
        <property type="gene ID" value="D3H35_17655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="102" mass="11247" checksum="CB90804DCA89CD57" modified="2018-12-05" version="1">MGRRWIAVALLTPVFLLGITGCWSKEELNDRTFAMAMMVDLTDEGKTELSMLFYLPNRLSTGVSASNSLQKPFRSSAGPAVTSPKLWTTFSTSSLEELRGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHD8</accession>
    <name>A0A398CHD8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cof-type HAD-IIB family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01392">
        <property type="protein sequence ID" value="RIE01392"/>
        <property type="gene ID" value="D3H35_23780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="255" mass="28343" checksum="D51C3BB07C254D1D" modified="2018-12-05" version="1">MTYKIAFFDIDGTLVNEEKQIPDDTVAAIRELQQSGVTAVIATGRAPYFFRPIAEQLGIDSFVSLNGGYVVYKGEPIYRYSIPRDRMEDLVAQASKNNHSLVFEGEEAYFANTDSHPHMISSVSSLRVELPGFDPDYWQKADVYQAFLHCEVHEEHLYDFPGLRMVRWHSSAMDVLPNDGSKARGILELLKRLNLTPEEAVAFGDGLNDKEMLSCVGLGIAMGNSHPDLLPFADYVTKSVDEGGIRSGLQHAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHJ3</accession>
    <name>A0A398CHJ3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Formate acetyltransferase</fullName>
            <ecNumber evidence="5 14">2.3.1.54</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Pyruvate formate-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">pflB</name>
        <name evidence="18" type="ORF">D3H35_24200</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>acetyl-CoA + formate = CoA + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:11844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Fermentation; pyruvate fermentation; formate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.54" evidence="5 14"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01462">
        <property type="protein sequence ID" value="RIE01462"/>
        <property type="gene ID" value="D3H35_24200"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00920">
        <property type="reaction ID" value="UER00891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008861">
        <property type="term" value="F:formate C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01678">
        <property type="entry name" value="PFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005949">
        <property type="entry name" value="Form_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019777">
        <property type="entry name" value="Form_AcTrfase_GR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01255">
        <property type="entry name" value="pyr_form_ly_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00850">
        <property type="entry name" value="GLY_RADICAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14 18" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="10 13 14" id="KW-0556">Organic radical</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFL" evidence="17">
        <location>
            <begin position="1"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="16">
        <location>
            <begin position="604"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="588"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="13">
        <location>
            <position position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RIE01462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="727" mass="80908" checksum="E450DFF43A7E658C" modified="2018-12-05" version="1">MDVNDFLGLNLTPYEGDESFLASPTEGTQRLWEAVLELMKRERDNGGVLDVDTETVSTITSHGPGYIDPALEKVVGLQTDAPLKRSVQPFGGIRMVVDACEAYGYKIKDELVSLFTDIRKTHNQGVFDAYTTEMKLARKAGIITGLPDAYGRGRIIGDYRRVALYGIDRLVEAKKEDLLQLETDAMTEEVIRAREELSEQVRALGELKRMAASYGYDIGKPAATASEAIQWLYFGYLAAIKEQNGAAMSLGRVSSFLDIYTERDLREGRLTEAQAQELVDHFVMKLRIVKFLRTPDYNELFSGDPTWVTESIGGMGNDGKTRVTRNSFRFLHTLYNLGPAPEPNLTVLWSTRLPEPFKEYCAKVSVDTSSIQYESDDLMRPVYGDDYGIACCVSAMRIGKQMQFFGARANAAKALLYAINGGVDEKLGIQVGPALAPLAGDTLDYDTVTKRYDEMLEWLARLYMNTLNVIHYMHDKYSYERIEMALHDANIVRTMACGIAGLSVVADSLSAIKYAKVRPIRNEKGLAVDFEIEGDYPQYGNNDARVDDIAVGLTEAFMSKLRKHRTYREAVPTMSVLTITSNVVYGKKTGSTPDGRKAGEPFAPGANPMHGRDRKGALASLNSVAKLPYESCLDGISNTFSIVPKALGKEADTRVRNLVSLLDGYAVKGGHHLNINVFNREQLLDAMEHPEQYPQLTIRVSGYAVHFIKLTREQQMDVINRTFHGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI16</accession>
    <name>A0A398CI16_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02433">
        <property type="protein sequence ID" value="RIE02433"/>
        <property type="gene ID" value="D3H35_17160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="371" mass="42085" checksum="63E67DC7CF37015B" modified="2018-12-05" version="1">MTQPLPPGATLPLTFAPGDALTADSLNRLQTELLSRILSHSHAGNTETDQEGVVLGSSSLADGSVEARHLAPNAVPPEAIPDRSVTRAKLAESLHELLAHLEHQTRHLREHIFRLESDMDEAKEAVYRENDRIALLNERLELALVIAEDARLKEQEDELRIENMENQIVHRDERFAKMEGAVAALTESFERAERDAERSRRDSDERLARIERGFNGLQERFDRLEATTTVQIAELVEHAERDEATDIAFRESVGEMVDRLVRTPLPTTWGYFRNYQDIVSYEEEYTQNIDAADIVSGADGETVELRFVRPYADKYYTVLITPEQRGVHALPTAVPVILHRDAETVRFGFWDGYRWHARNGAWNIAIFGLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI96</accession>
    <name>A0A398CI96_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_27865</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00558">
        <property type="protein sequence ID" value="RIE00558"/>
        <property type="gene ID" value="D3H35_27865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026032">
        <property type="entry name" value="HcaT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004925">
        <property type="entry name" value="HcaT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="176"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE00558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="390" mass="42891" checksum="CFADA89E95FA2F95" modified="2018-12-05" version="1">MKDNMNLRAQLWILRSLQFASFATMALVVAFFPLYFDSLGFSKQQIGAIYSIGPVLSIFSNLLAGFVSDKTKNVRRVLNLLFVGQILALALLLPQKEFGLVAGVMALFYLFQTPVNSMLDSVSLLAAERMQISFPSIRVFGSLGYAVSAVAFGYLLKVSDSTLTLKIGLATTACALLFSILLGNFQASVKKFEFGGLWALFRRREVVLFFLFIAFVSISHRMNEGFLSVAMRDNGASDFLIGTASLASAVSEMPIFFLLAKYGQRFKELPLLAIASIMYVVRLSLLSFADEPWMFVALQMMHSVTFGIFYITALRYLLTLVPDEYRSSGQALFTVVWSGIAGLVAGLLGGWLYDSAGLSFVYRIGACTALVSAIGFLYSHISPSRRADRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIZ2</accession>
    <name>A0A398CIZ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_11215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03266">
        <property type="protein sequence ID" value="RIE03266"/>
        <property type="gene ID" value="D3H35_11215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017331691" evidence="2">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="62" mass="6683" checksum="5D5AA4F2A861E98B" modified="2018-12-05" version="1">MRNRTKSLSIGLVVLLLFAFTLAGCGSSNKKNEASPSGSSSPAVSRRLRKLPRHPTRRSCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ89</accession>
    <name>A0A398CJ89_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MmcQ/YjbR family DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_11905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03376">
        <property type="protein sequence ID" value="RIE03376"/>
        <property type="gene ID" value="D3H35_11905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="114" mass="13129" checksum="84F30A6DFB328188" modified="2018-12-05" version="1">MISVDEIRSYVLTLPETVEVEHWGKPSFRIKNKIFVVLQEDGRTLTVKTIGDDRAIYTELDPTTYRIPDAYAKLSYMHMNINQVEPEEARGLIYKAWSSVAPKRLVNRKPGTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJB4</accession>
    <name>A0A398CJB4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03406">
        <property type="protein sequence ID" value="RIE03406"/>
        <property type="gene ID" value="D3H35_12095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="67" mass="7741" checksum="7AA1519A4D5A1F4D" modified="2018-12-05" version="1">MEKRQAPSPLETDNGRQPSRPSAKSRRVRIAMLGDVIRIRPRTGLHQPPALWNVRNERYCFPSTRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJU4</accession>
    <name>A0A398CJU4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MgtC/SapB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_17040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MgtC/SapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02412">
        <property type="protein sequence ID" value="RIE02412"/>
        <property type="gene ID" value="D3H35_17040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="166" mass="18114" checksum="9CAA2EFCA3206E55" modified="2018-12-05" version="1">MKRVEAIYSWFERYLLDDSEMYLRILLSAVLGFIIGWDRESKSKPAGIKTYMFVCVASCLITLISIYSVDKFSSLNNRTMMDPLRLAAQIVTGLGFLGAGVILKNGLEVKGLTSAAMVLFVGGIGIGIGAGFYALIVFAVLVSMVMVRIGNAIEQSKFVRAKGKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJW5</accession>
    <name>A0A398CJW5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02432">
        <property type="protein sequence ID" value="RIE02432"/>
        <property type="gene ID" value="D3H35_17155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="223" mass="23192" checksum="7733303ED38C8D98" modified="2018-12-05" version="1">MIRALEARLAAWVADRLESLGQQSGWLGTIYTDIGVLNNGQGRRLNNSDVLVQIQVAGLAPAVGGTAPSPDQVVGTCRISLRLLGQTSHELGGDAAGSTATSESDANAEQSNVHAIDLAAFTLLAGLKEPPVAAPSGAAPDPARPAPVGTIAIQAGTSSAALAWTDLRMVSTSIVPLNDEGLRQWDIPLEASFIFRMSPLRTESAFIRRAPQAVNVIKPPEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK60</accession>
    <name>A0A398CK60_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02532">
        <property type="protein sequence ID" value="RIE02532"/>
        <property type="gene ID" value="D3H35_17735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="365" mass="41986" checksum="0D0617114E410B7D" modified="2018-12-05" version="1">MALFVMIIRKMAQNKWLVISLFLGMLMSVALVSTMPIYSEAILSRMLVKDLEEQQTASKQYPAIHYTKLGFVVEKPEKRRQVIAELNRFMKEEAAPGFAIPVKELTTEYQTKAFELEIEGKPVEVGEKKPTTTLMAMSGLNDHIKLKDGRLASDQPVDGVYEVMVTQKALIEYNFVLGQVIKLDDDKLNLHFKIKPVGVFEKKQDDDLYFRAPDLSNVSRAFVVNDKLFDKEFLAGGKAPILASSWFFVLDYSKMELSTIDNFINTDKLIQDKAKSMVQEYQLDYWVPAMKTIETYFERSEHLYKLMWSLNVPVLIMLGFYMFMVSNLIVDRQKNEIAVLRSRGLPDGKSCWRSLSKALLLAERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK76</accession>
    <name>A0A398CK76_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MurR/RpiR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_23105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01278">
        <property type="protein sequence ID" value="RIE01278"/>
        <property type="gene ID" value="D3H35_23105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="122"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="282" mass="30929" checksum="2793C4E49AC0413B" modified="2018-12-05" version="1">MNGGLVRLKEIWNEVTPSEKKVAQYILDYPEETIQLSVAELSARSGGSQAAIIRLCKSMGVKGYQELKLKVAGDLQSGEDSGYQEIRPMDSVENIVHYVSNNNIQSIRDTVKILDMEKMTQAIDVLHRAKRIFFFGLGASNIVAVDAQNKFMRINHTSFAFSESHLQLTSAVTMEADDVAVGISYSGEADFVIACLKKAKEAGAASISITKYGNNTLGGLADIPLFISSTENEIRSGATASRIAQLNVIDILYLGVASRSYDQSVMYLEKSRAALREMSQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKD2</accession>
    <name>A0A398CKD2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF456 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02760">
        <property type="protein sequence ID" value="RIE02760"/>
        <property type="gene ID" value="D3H35_19150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007403">
        <property type="entry name" value="DUF456"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04306">
        <property type="entry name" value="DUF456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="161" mass="17202" checksum="73BB60B2977664E6" modified="2018-12-05" version="1">MDVLGWILIIVLFVVGMAGAVYPILPGALAIYAAFFVYGLFFSFGPFGFWFWTIQTLIVAVLFVADYVVNAWGVKKYGGSKASIWGSTIGILIGPFVIPAFGLIIGPFAGAVIGELIHGSSADRAIKVGWGALVGLFTSTVVKFILQAAMIALFVVWLIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKF9</accession>
    <name>A0A398CKF9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_24180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01689">
        <property type="protein sequence ID" value="RIE01689"/>
        <property type="gene ID" value="D3H35_24180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="62" mass="7308" checksum="B24F028CB7A0E37A" modified="2018-12-05" version="1">MKTMETRITENLLRFCYPCPHADECTTEEDCRACWAERAAIEDEEEEGPALTRRLLRECEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKG5</accession>
    <name>A0A398CKG5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrABC system protein C</fullName>
            <shortName evidence="6">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">uvrC</name>
        <name evidence="11" type="ORF">D3H35_19330</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UvrC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02790">
        <property type="protein sequence ID" value="RIE02790"/>
        <property type="gene ID" value="D3H35_19330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="GIY-YIG" evidence="9">
        <location>
            <begin position="34"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="8">
        <location>
            <begin position="216"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="10">
        <location>
            <begin position="267"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="323"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE02790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="688" mass="77184" checksum="7213386773BE91D3" modified="2018-12-05" version="1">MPDQPISDGSPPAPFQDRDKAMDNIRNKLALLPDQPGCYLMKNIDGTIIYVGKAKVLKNRVRSYFRGSHDGKTQKLVSEIRDFEYIVTASNMESLILECNLIKEHHPRYNVLLKDDKSFPYLKITHEAHPKLEVTRRIVKDKAKYFGPYPNAFAAQQTKKLLDRLYPLRKCGTLPDKVCLYYHLGQCVAPCEYPVEPSEYERMTGEIARFLNGGHGEIKRDLQRKMEEAAEGLEFERAREFRDQIAAISALMEKQTITMADAMDRDVFGYAVDKGWMCVQILYMRQGKMIQRHVSVFPYYGEPYDDFLSFVTQYYSDNPALPREMLLPVPPEETGGEAAASGESSGAESPAGLREQVPAEESFPTSLEASQPPLDSEDTADEAAEEGESGEIGDSLRKWLKIKVAVPKRGSKRQLVAMACDNARVALQEKFRLIERDEERSVKAAHGLAEWLGIPSASRIEAFDNSNIQGTNPVSAMVVFTDGKPDKKEYRKYNVRGVEGPDDYSTMREVVRRRYERVLKEEMALPDLIVVDGGKGHIAAALDVLVNELGLDVPVCGLAKDAKHRTAQLLVGDPPEVVPLPRDSQEFYLLQRIQDEVHRFAITFHREKRAKSMIASRLDAIPGIGEKRRKQLLKHFGSLKAIREASVEDFREVSIGEALAQRILEALREKEEAGASSGTTGSDGGSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKG7</accession>
    <name>A0A398CKG7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylserine decarboxylase proenzyme</fullName>
            <ecNumber evidence="7">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="7">Phosphatidylserine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="7">Phosphatidylserine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">psd</name>
        <name evidence="8" type="ORF">D3H35_19705</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="7">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02855">
        <property type="protein sequence ID" value="RIE02855"/>
        <property type="gene ID" value="D3H35_19705"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00662">
        <property type="entry name" value="PS_decarb_PSD_B_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033178">
        <property type="entry name" value="PSD_type1_pro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PTHR10067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="6 7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023419138" description="Phosphatidylserine decarboxylase beta chain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023419139" description="Phosphatidylserine decarboxylase alpha chain" evidence="7">
        <location>
            <begin position="227"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="7">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="7">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="7">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="7">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="7">
        <location>
            <begin position="226"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="7">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="263" mass="29889" checksum="14EFEB5BD8447EE6" modified="2018-12-05" version="1">MNRPLLRLMTELSSRKFISRLAGTIAKSSLSRRWIPRFAALYKIPVEEAEKRLEEYGSLNEFFTRRLKPGRRPIDDSSEAIVSPVDALITACGTIEDGMLLQIKGQDYTLDELLNGSPRTSQYRHGYFWVLYLSPTDYHRIHSPCEGDVVESEHIPGRVYPVNDFGLKHMKRVLSRNERLVTYIRHAIGEVAVVKVGALNVSSIRYVEPLPKHLERGGELAYFEFGSTVVLLTEDGTLDPRTNLQVGDKVRMGERLGTLTEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKH2</accession>
    <name>A0A398CKH2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">pyrB</name>
        <name evidence="9" type="ORF">D3H35_29510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00181">
        <property type="protein sequence ID" value="RIE00181"/>
        <property type="gene ID" value="D3H35_29510"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="154"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE00181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="308" mass="34143" checksum="065F2A609FAC011C" modified="2018-12-05" version="1">MERNLYHVLGAKQFGREDLDRLFAEAREMEKVVAAGGDRRFTGKIMTTLFFEASTRTRLSFESAMNRLGGSVIGTENAAQFSSAIKGETLEDTIKIITGYSDVIVMRHTDIGAAKRAAKVSGVPVINAGDGAGEHPTQALLDAYTIGKELGQIDGVKIAMVGDLAYGRTVHSLSYILANYKDVMIYYISPENVQIPASVKRYMDEKGIRFAETTDLDSVAGDVDVVYQTRIQKERFPSIEEYEKASGQYIVDRELLDRMRKNSIVLHPLPRAGEIAEEVDADPRAAYFRQAQNGLFIRMALIDKCLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKM9</accession>
    <name>A0A398CKM9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine kinase</fullName>
            <ecNumber evidence="1">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_13225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01759">
        <property type="protein sequence ID" value="RIE01759"/>
        <property type="gene ID" value="D3H35_13225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="47"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="417" mass="45876" checksum="B9797417624FC60B" modified="2018-12-05" version="1">MAAALSIRRGLGYDGGLLRFGRLDHSAAMAGAIGRSRGWKWRPCMTTLMIVDDHRHIVEDLATTISWSEHGVTRVLQAYSGPEALERLRRESVDIVVTDIRMPVMSGLELIREIGTSNPQTDCLLLTGHAEFEYARQAVELGAAGYLMKPVRHEELVHTVTRVMNNRAARLAETAEASRLRDTVRIELPRMRAELLAARSEAEQAAETERARIVGDIHDIVGYTLTTMIVQLEVVGKQLKLDREAGIERLEQSKRFMHQSLGEIRETLGQLLTMEQNAGEEEPDDLASLIERFLQGAERAVCISVERRISLSQPIDDPALIKALLNALQEGITNGVRHGGAETFRFCLEAAGGDLRFELWNNGKPYDGADSGTGLYVMSERVGKLGGRAGLFATSDPEGTLLTISIPSAGWLRADGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL27</accession>
    <name>A0A398CL27_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OMPdecase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_21255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03105">
        <property type="protein sequence ID" value="RIE03105"/>
        <property type="gene ID" value="D3H35_21255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="216" mass="23430" checksum="D9B902EA81C8D5F9" modified="2018-12-05" version="1">MKPIVQIAIDTTSITDACRMADAAVEAGADWLEVGNPLIKFEGVHAIEALSKRYPDQYLIVDYMILAGAKKYIQAAKERGAKNVTVFGLVPDYSIQNAIDEAKALQMHVTIDLFNCSDPVESARKFAAMGADYVMVHFGVDQKKQFPNGSPIPVLEQVVKAVSIPVAYATYDVNESIAAVKAGASIIVQGEPLISGPNAEEELRAFIYKTKHSVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL90</accession>
    <name>A0A398CL90_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_20485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02982">
        <property type="protein sequence ID" value="RIE02982"/>
        <property type="gene ID" value="D3H35_20485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="611"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="678" mass="77656" checksum="08F68239F09E5EF7" modified="2018-12-05" version="1">MNFVREPMSERFIYDAINRLEEHYFVGRTEQTERFVSFLRESGSSEIILNVYGTGGVGKSYLLREFARIAAAQGRIVCQLDARTFRHTPEAFIAAVMTSLQQPASNEVSADFPEAVALHNCLNIMNILADRHRFVLFLDEYATMRGLDGWLQDAFFRGLQPNVRIVVAGRTPLDGSWVSSPAWRRFIASMPLEQFSKHDVSEYLARNDIVDEAAIEKAWVVSGGHPLYLSLTVPLLSRCPDLASLPFVELNSELVKHWLKETTTEEMRSLIEYMSIPRTFNQELLGYMRGFPVTDVEFASITRLSFVKASARGWVMQDRIRETIHSEFKKRMPKQYQGGLIRCANYWYALIHRRASSVHSAADIRDYICCVSDSMVRSVFQHSGINSKNRLETMDRRNFHEVKRYLNKRKFQAKTKQAYYVDNQKQQTYTFHMDPRQDEKRAVLARPEDWLALELDSVKLLRNDTGSMIGLVAAIPINRSTLNYLSEQPVTSSFFRALSEEDRSALAAPRHTQAGWVLRMLDVEDGNDSEARSELLNYWLEYLQYGNLLLVSTPDSFYRKLLLALGFREADVPAHYDYGENTPAPTYMLDLRKDRFLSYLHGMSHMAGIPLSVPNIALSGRESEIASLVLQGLTNNEIGKSLYLSEITIKKHVSNIFRKTGTKNRSQLIRSLMEISPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLA1</accession>
    <name>A0A398CLA1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_12340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03443">
        <property type="protein sequence ID" value="RIE03443"/>
        <property type="gene ID" value="D3H35_12340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="27"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="649" mass="73539" checksum="6BD06624CFC84B2F" modified="2018-12-05" version="1">MSRYPFEFEHAKPFLQQAGEWIADVFYDILPEAGFEVRDEQIYMAFQLERAFAEKKTIFAEAGVGTGKTLVYLLYAICYARYTRKPAVIACADESLIEQLVKPEGDVAKLAQHLSLAIDARLGKSPDKYLCLVKLDEARGGPEYVEAYQDIHDRLPSFVNKFEAMQTFHAYGDRREYPDLNDEQWNSISWDPFQDCFVCERRHRCGQTLSREHYRQSADLIICSHDFYMEHVWTYEGRKREGQLPLLPEHSSVVFDEGHLLEAAAQKALTYRLKHSVFEQLVSRLLQNEIRESLAVLIDEAIDRSEALFDLLSRQSVAIAGSDRKHIMITERLQRDVSAFRGVIEAIEEELVFESELYTLDDYQLRIVEEHLEMIQKALGLFQQSASLICWATDSSEGLTLVIMPRAVKEVLRERVFGSNVPVVFSSATLSVDGSFDYVADSLGIGDYLSFSVDSPYDYADQMEAVAPTWPPGGAAFTDKMTAAARLLGGSDGGALVLFPSKEELQRFKASISSYSECANKRILFEGDREISHLISDFQNDEASILCAVSLWEGLDIPGPSLNKVIVWSLPYPPQDPVYMAKRQAAASPFEEVDMPYMLLRMKQGMGRLIRSRDDRGFVAILSEEIHDDSKLRERIEALLPEGVALKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLK0</accession>
    <name>A0A398CLK0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asp23/Gls24 family envelope stress response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00727">
        <property type="protein sequence ID" value="RIE00727"/>
        <property type="gene ID" value="D3H35_26390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="136" mass="14802" checksum="E0BED2735C414FF8" modified="2018-12-05" version="1">METLAPDYERTDLGTIEIAPEVIEVIAGLATVEVEGVAGMSGGISSGIAELLGRKNMSKGVKVEVGQREAAVDVNIIVHYGRRIPEISAEIQRNVKQSIQTMTGLNVVEVNVHIHDVHFGKSNDKPEEEETQTRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLM5</accession>
    <name>A0A398CLM5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_14475</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03132">
        <property type="protein sequence ID" value="RIE03132"/>
        <property type="gene ID" value="D3H35_14475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="37"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="355"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="388"/>
            <end position="395"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="596" mass="65633" checksum="A788B4344369F3D0" modified="2018-12-05" version="1">MSSLKRLSEAHEARAKLSEVKLSRVLSLFRPYWKQLAFILLLSLAAALVGLIAPLATKEIVDQAIPKKDFGLLAIFALLMLASPVGKGMLNVWQTHLNNKVGQSVMRDLNDSLFRNLQRQSMAFFTRSRTGEIVQRISGDVQAIQSAITGTIVSAITQAVTLLATATILFRLDWKMALLSLVVLPGLLLPVRRISSLRKELRLKVQKQRGEMSSHLAETFGVSGALLTRIFNREESQVRKFAAMNDSVKSMELRLGLIGRWYAMAAGVTNPIGAAVIYLYGGWNVINGDMTLGSVIAFAALTGRLYDPVSGLLNVHLELSAAMGIFQRIFEYLDLEPDIEDAPGAKPLSKLQGRVEFRGVGFSYRPDAPALQNLSFEVEPGGMLALVGPSGAGKSTLIGLIARLYDPSEGGVYVDGQNIREATLHSLRSQIAYVTQEPFLFYGTLADNLRFAKEEATQEEMEDACRRAYIHDFIQSLPEGYETMVGERGHRLSGGERQRVAIARAILKEPRILILDEATSHLDSQSEAFVQEALEQLMRNRTTIAIAHRLSTILAADRIVVLNEGRIVESGTHAELLDEGGLYAQLYHTQFVPSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLP3</accession>
    <name>A0A398CLP3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_16125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03152">
        <property type="protein sequence ID" value="RIE03152"/>
        <property type="gene ID" value="D3H35_16125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="194"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="295" mass="34376" checksum="D233B4C26E323471" modified="2018-12-05" version="1">MEVNNLALLREPMPMPNPAFPIKIHPRWTSPVEVGSLLFPHHWHEHIEFLYFVSGKATIECGSVPYTFNAGDLCVVNSNELHYGIANDVDLSYYAMIVDLSLLHSHSEDAVERKFISPITENRILFHNKIASDGEIAGCMMAIHDELEREEIGYELAIKSHLYRLLSLLVRGHVATVRNREEYDYRIKELERLAPVFLEIDKRYKEKLTVQRLADLVGLSRFHFSRLFKQLTDKSLVEYINLVRINKSESMLRSMRMTISEVAHETGFNDIYYFSRTFKKLKKMSPSEWRNAARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLZ0</accession>
    <name>A0A398CLZ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2726 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_27245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00661">
        <property type="protein sequence ID" value="RIE00661"/>
        <property type="gene ID" value="D3H35_27245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024402">
        <property type="entry name" value="DUF2726"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="PTHR10887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10881">
        <property type="entry name" value="DUF2726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_11" evidence="2">
        <location>
            <begin position="177"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_12" evidence="3">
        <location>
            <begin position="547"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2726" evidence="1">
        <location>
            <begin position="790"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="917" mass="106534" checksum="5BDC832417750A9C" modified="2018-12-05" version="1">MDERTVLIVTDKGDQTKDIAKYTVLENGVEIQFKSRLEPYTYSTSKVSIKRNPIPIDIRDHRVLYRGMPLRNVQEMVDFEGVIKVFFGDKHTQIYDSALIRLEHADGDNNKIGELMEYWAEIAQHVKTDDEPETFLKKQYSKLNAIHPESVLAAYMNQTLSTQSNRSSIPAIFPFRFNLSQMQALEQALLSKISIIEGPPGTGKTQTILNILANAAIMQNKSVAVVSGNNAAVQNVKDKLQKYGYDFIAASLGKKENKQAFFRNLPEYRVTEWKSEIQVEQLTETVRDLSERLKRLLGLANRKAKLDQDIAAYRLEQKHFHIHNRSQDLDGIKRLFLRRQTPDTIIAFLADEYFTGNRSLRFFHKANLLFKYGFFDFKKLKESRLEWITKLQMKYYESKLAELEQESSDIQMELDRYSFSDLLDRHESYSSALFKHKLHHKYEGKTTYQGSMGSYIRDFDEFIESFPIMLSTTHSLRSCIPEDFLFDYVIIDEASQVDLLTGVLALSCCKQVIVVGDTKQLPQIVDEKIQSKLVNRPSNETYNYFKHSLLSSMLAIYGENVPRVMLKEHYRCHPTIIGFCNSQYYKGDLIPFTPEKEADIPIRLHYTAIGNHMRRVTVKGKEGKFNHREIDAIKEEILEELRLVDVPMEHIGFTTPYRLQVEEASLILDHKIEIDTVHRYQGREKPIMILSTVLDRTRNGQIGKKFVENSCLVNVAVSRAQNQFILVTDHALFRNSRKDIGNLIRYIEYNSLHEHITSSELISVFDLLYSEYSAKLNQLQSRLVSKSRYKSENIMWRVLTDLLSEEKYKSVFFGTQVYLKDLFNNEIRFRESLNEQEESYIRNRASFDFVIYDAINKQPLLAIEVDGFASHRNNPDQPKRDLMKDSICTKYHLPLLRLPTTGSDEITKIRNALEQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM26</accession>
    <name>A0A398CM26_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03495">
        <property type="protein sequence ID" value="RIE03495"/>
        <property type="gene ID" value="D3H35_12670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="115" mass="13074" checksum="26C476760E9E1344" modified="2018-12-05" version="1">MALRPAYSVRLSIDWERVQNHLDETFGSDSIFYQSQITEAVDKLIDNRVIVIEDDLFVVEGEDEGLTARHEQAVDEVRSMITDAFFTPSLNPIEPEKEDTGTRSNISPKPLPRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMB8</accession>
    <name>A0A398CMB8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000035">
        <property type="protein sequence ID" value="RIE03595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03595">
        <property type="protein sequence ID" value="RIE03595"/>
        <property type="gene ID" value="D3H35_10675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="134" mass="13970" checksum="33576AED271E2D8B" modified="2018-12-05" version="1">MDSRAIDASGVGRRNRPALPERKLTAASIRLMPAQVDIDSVTLAIGDGSGTFADLQSVRSSGYPPFSALFNTALTSEQSGQATAALNGSPDRLTVTYRGQVQRSGQGAAQLAATADLSRWLPAGTSANYIRSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMJ4</accession>
    <name>A0A398CMJ4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_17320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02459">
        <property type="protein sequence ID" value="RIE02459"/>
        <property type="gene ID" value="D3H35_17320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017376872" evidence="2">
        <location>
            <begin position="32"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="75"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="329" mass="35952" checksum="E5E425E1607F3954" modified="2018-12-05" version="1">MAQAKKAVPVLMVLIMMGALLIACGKNSNGAADESKATHEAAKETASPESKAAEPVTHIVTDWTGHQVEVPTHPKRVIYHGEVTGDVLALGVTPVGALKGSGTVYDDRLTSTEDIGFPINLEKSMALQPDLIIFSNNDEQQYEQLAKIAPTATFDSFASLENRLRALGDLLGKKDEAEAWLQNYNAEKAAMWTGLREQTIKENETASVFTMYPGNRLFVMAGAGLPQFLYDEQGFKPLAKVQELIDQGTGFIEISAETMQEYAGDRIFILNPVDPAAQESTNELMKGSVWNSIPAVKNGYVYRFDILKASGDALSREWMLQELPKALNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMP1</accession>
    <name>A0A398CMP1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydrolase Nlp/P60</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_09445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03873">
        <property type="protein sequence ID" value="RIE03873"/>
        <property type="gene ID" value="D3H35_09445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017194375" evidence="2">
        <location>
            <begin position="30"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="3">
        <location>
            <begin position="32"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="185"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="330" mass="35700" checksum="CD8609FEF56EEC08" modified="2018-12-05" version="1">MEVLHMRRQIAIALAALSLLLTVPSITAAAAKNGSAVVVSSVSFRTAPSTSSSVMKYLKAGEKVVLLEQPNDYWYKVKDASGTIGYISSGEKYVNVVTPIQETAVGANAVAVGSVTFRTKPSTSGERIRYLKVGEPIVVTAREGAYWYAVTDANGVSGYVSNSSAYIKLTGTIPQPSQPSKPTADQQIEAVIAAGMRYLGTPYEYGSSRDNTATFDCSDFVRQAFFDGLNKLLPADSRQQGEFVRANGSVQTDWHQLKRGDLMFFMDYKGTKAASYTGKKPFSEKITHVAIYLGNGQMLHTYSVDSGGVRTNAIGGNHWEYRFLYGGSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMR9</accession>
    <name>A0A398CMR9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HEAT repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03903">
        <property type="protein sequence ID" value="RIE03903"/>
        <property type="gene ID" value="D3H35_08005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="305" mass="34674" checksum="A77A2E4EDDE4DA1B" modified="2018-12-05" version="1">MTDQTRDNLVLFPKTLDYYQIQLTKMLETERYGDAKSLLSFLLHCKGDAERHHTEWQALLGWLEAAFPEAQPIDGLPDSIEDDEEENEADWARKHTIDRSEQDAEYLPKLIATLQSAADPDQQALVIGQLMHLSHPSIEEALRQWLAAPAHHPSVQFKALQALRKQGAVGPTPVWRGGETLLVEVADTPLSFGEFAQGVLDVLERVRQAAEVSDPTLSYFAEEFWKECVQTAFGTSIYRSMAEDDDGSRDIWAAALHQLLMEKLHGRLSDESVREQYGITDELRFRYEQALRWLRQYAAEPGKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMU2</accession>
    <name>A0A398CMU2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cu_amine_oxidN1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_22805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01227">
        <property type="protein sequence ID" value="RIE01227"/>
        <property type="gene ID" value="D3H35_22805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="2">
        <location>
            <begin position="80"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="545" mass="59612" checksum="D197E8C85C2C74A2" modified="2018-12-05" version="1">MDWKLGKWSLDRGIWEVGQVMSSERKWIYWIGTALLAIVVATGGSDLSFAAGKAQPPINVVVDGAKTSLAVNPYLGKEGIMLPYATLFQALKIDARLERKTLVVRRANTVYKIDIGSTKLMVGNRQVRLTTAPVIVNGRVFVPKRYVELVLDKQVTYDAKLNLVTIGLTEKAKLALQKMLFEAARLGDAATIEKVVKQGIDPNGKLKQIYLDNTALVYAVNNNRTAAVRALIKNGAKVIESERYLGTRAISLQNAEILGLLLDAGLDPNYREYGNTLLETASTISSTVLELSEVTQGPSPAVVETLLKHGADPGLDDSLARAIGSQNYSIIQLLLRAGAKTDKPDRFGQLPYNMAASYNIQRWMSIQNDQPKIPTFVMEDDQGVRIHTGAVAFRSLSAPSSGSYYTNWSLDTIYADVPDGSYQVTEHRMYGQTTLFPSSMSFTVKDGVISPSVQRLPTPNVAGKIVGDPSKQAIGGHLELTNEQASFYSIIEVDGDHFKLSIPPGQYKLARYTSSNGTVYPLNKAITIENKDGVQELIVQIGEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMY1</accession>
    <name>A0A398CMY1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spore gernimation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_10150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03652">
        <property type="protein sequence ID" value="RIE03652"/>
        <property type="gene ID" value="D3H35_10150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004761">
        <property type="entry name" value="Spore_GerAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34975">
        <property type="entry name" value="PTHR34975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03845">
        <property type="entry name" value="Spore_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00912">
        <property type="entry name" value="2A0309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="347" mass="38841" checksum="5F1925C0F0F4B723" modified="2018-12-05" version="1">MIINFILAAGILSFPRVISERMGTPDGWISILLSGGLAMVEGIIIVKLSQRFPQKTFFEYSQEIVGRWVGIFASILVIGYFLVLSAFEIRMMAEVTNFFLLEGTPSWAVIMPLMWVALYLMLGGIQPIARLFELILPITALVFLIAIFLGFHIFDIDRLRPVLGLGLWPVFEGMKESALYFLGSEVMLFLVAFMQKPDKGVKAVVSGVAFTVVFYLITFVIVIGALSLEGTEARTWPTVDVLRSFELQGLFFERFESLLLVIWIMQIFSTYTTAHYGAALGLAQLFKKDISPFAYGLLPIIFIVAMAPKSVNDVFSIGDFIGNFGLWYFGLFPLLCLIAAKWRGRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CND2</accession>
    <name>A0A398CND2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_21965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01091">
        <property type="protein sequence ID" value="RIE01091"/>
        <property type="gene ID" value="D3H35_21965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="138"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="138"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="242" mass="26895" checksum="2D26179986253CC7" modified="2018-12-05" version="1">MMNPRILIVDDEPSIVKMLHMVLQKEGFEQIYTAGSCRAALDALDRHGADIVLLDVMLPDGSGFELISQIRTRGNPHVFFLTAKVSDLDKLTGFAMGGDDYITKPFNPLEIAARIKARLRRTDSSAVAGLPASPSSSSPSYDFGRFRLFEASGELYVGDALVSCPAQVFQLLLYFCKHPGILFSKTQLYEAVWGIDGFGDDNTVTVHIRRIRERIEADPSAPKHLVTVRGLGYKLSKEYLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CND5</accession>
    <name>A0A398CND5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04005">
        <property type="protein sequence ID" value="RIE04005"/>
        <property type="gene ID" value="D3H35_08605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="192"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="415" mass="44544" checksum="9C2EF90F647216B2" modified="2018-12-05" version="1">MTLDTTPIFALLKEREKDWIALRREFHRQPELMYDVDRTATRIAALLESYGLEVQRNVGHHFGKGIVGILRGGKIGKTVLFRADMDALPIQERTGADYRSAVEGAMHACGHDAHMTMLLAAAYGLSRFRDRFAGTIKFVFQPAEEGAAVSPVDGILRSGGRDLVESGVADDASAAFAFHVWPELPAGWIGVHRGYAMAASTHFRIAFRGRSGHHGSPHLAADALLMAAHFAAEARAAVYAAVDPLEPFAFAFGTLRAGTVINAIAESGEAAGTYRAFEERTVLRVRSVLERCAAACAERFGGEYEASFRMGKALINDARGVEAVLRAGASAAGSERTVLLEKPSLAGEDFAYYLDKAPGAMVLIGVGNAEKGIVHPLHHPEFDLDESALVVGAKLFVQLVAEVGEGSIVGTEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNG5</accession>
    <name>A0A398CNG5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01121">
        <property type="protein sequence ID" value="RIE01121"/>
        <property type="gene ID" value="D3H35_22145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="346" mass="39216" checksum="7AF7941E5D27BA84" modified="2018-12-05" version="1">MKFALFSLIMNNPNPVTGETFSDHQQLHNVLTQAELAERLGFDAYGVGERHGPPFLSSSPPVVLTAIASRTKRIRLLTTVTVLSVLDPVRVAEDYATLDHLSEGRLEIIIGKGNDPRHYPLFGIREEQQWDSLAERYGLLRRLWDEENVTWEGKYRPPLHEVTVLPRPYQKKIPIWHGSASSQLSTELAAQYGEPLFSSNTFHQQEKYKALIDHYRERLAFYGHDPRKAIVGAGAGSLYLADSPEEAIKRFRPYYDAYFSTPSSLHNQSPFKDLEDHVARGSMLVGNPESVVEKILNYREAFGNEVLSISVDGLSATEQREQLERFAEEVAPILRREVPSSVWNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNN6</accession>
    <name>A0A398CNN6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04105">
        <property type="protein sequence ID" value="RIE04105"/>
        <property type="gene ID" value="D3H35_09180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="291" mass="34181" checksum="2C1F9A548FF2DC83" modified="2018-12-05" version="1">MLAKSVKDNAKHCKLVLCLVEEDIHPDAKKFEGFDHVVLAKDLGVPNFYKFVAKYNLYEAACALKPYLLQYAFEYYGKEEKFLYLDSDLCVYGSLDHLEALLEDHSILLTPHRLEPQEILNSIDEEIVNLKDGVYQAGFFGVRRTAESAKFLAWWADRNKDYSYADPNEGLFLDQKWLDLVPCFFDGVHVIQDPAYNMASWNLSQRKLTLSDKNQYLVNGKPLVFFHYSGMGKWLDNSMRLHVPDQSNAIYRMVNDYVLAYTKMGYHKYIDIPWSYENFDYERHLMKQWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNP5</accession>
    <name>A0A398CNP5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04115">
        <property type="protein sequence ID" value="RIE04115"/>
        <property type="gene ID" value="D3H35_09240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="117" mass="12766" checksum="B5FBAE1E59E0F372" modified="2018-12-05" version="1">MPVFRSDQDGDFALRREKGREYAAGRFDGQSGCTTSADASSVERFLHGSSAASKLEGLAARSMRSIRMNAPMVQNKRIWRYAVPSVTLSADRNPGSLRSRVSSAVLRNKAVRTTTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNP9</accession>
    <name>A0A398CNP9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01201">
        <property type="protein sequence ID" value="RIE01201"/>
        <property type="gene ID" value="D3H35_22655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="156" mass="17567" checksum="D3C6BE0DC8A86890" modified="2018-12-05" version="1">MNVIIERALVSDAEQILTLQKLAFRSEAESISNYEIEPLVQTIENFKSQFESHIVLKAISDGTIIGSVRAYVKDGTCFIGKLIVQPEYQGRGIGKSLMEEIEKACPATRFELFTGSNSEKNIGLYNRLGYQVFKREVIGHYLTLVFLEKSCKSLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNW8</accession>
    <name>A0A398CNW8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02969">
        <property type="protein sequence ID" value="RIE02969"/>
        <property type="gene ID" value="D3H35_20415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="171" mass="20105" checksum="598054C5D26F69A2" modified="2018-12-05" version="1">MKQQGIEFRILSADKGRSAEIKHFVLAMMSNLYPRGAYYENPYDLAFFEEVYIQPANANFFIAEDRKGRIVGTAAVKPYDRRFPEAEPFIGNGPVCEIVKFYIHPESRRMGIGSRLYEKAEQFAREAGYEENCLHTSLHLPGGYPFWQSRGYCERYWESERIVHMSKRWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP36</accession>
    <name>A0A398CP36_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phage tail sheath protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_23240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myoviridae tail sheath protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01301">
        <property type="protein sequence ID" value="RIE01301"/>
        <property type="gene ID" value="D3H35_23240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035326">
        <property type="entry name" value="Phage_sheath_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035089">
        <property type="entry name" value="Phage_sheath_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020287">
        <property type="entry name" value="Tail_sheath_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04984">
        <property type="entry name" value="Phage_sheath_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17482">
        <property type="entry name" value="Phage_sheath_1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17481">
        <property type="entry name" value="Phage_sheath_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_sheath_1N" evidence="3">
        <location>
            <begin position="94"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Phage_sheath_1" evidence="2">
        <location>
            <begin position="182"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Phage_sheath_1C" evidence="4">
        <location>
            <begin position="336"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="438" mass="46302" checksum="17BAF855993C6677" modified="2018-12-05" version="1">MAGGTWVAQNKVRPGAYINFVSEGGALGSVGERGIVAAALVLPWGPSKQILEINAGDDVSELLGYDIAAPELLLIRESLKRAKTLLLYRLNTGTKASKAIGVLTATAKHGGARGNDLTIIVQTNVDDNAKFDVITVLEGEEVDRQVVSAIADLAPNAWVTWSGTGTITTSAGAALTGGADGTAVNGDHTDFLAALELRDWQTVAYPGTDNVLKGVYAAFARRLRDTEGTKVQAVLENYPVADHEGIISVKNGVVLSDGTTLTAAQATAWVAGATAAATIAESLTYQAYDDAVDASPRYTNSQTITALEAGELLFTVSGGKAIVEQDINSLTSFTPDKGKQFRKNRVVRVLDGVGNDFKRIFEAYYLGKVNNNADGRNLLKAEIVTYLASLQAAGAIQNFDSQADVQVTSGIESDSVYVELSVQPVDAIEKIYMKVKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP76</accession>
    <name>A0A398CP76_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formate-dependent phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">6.3.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">5'-phosphoribosylglycinamide transformylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Formate-dependent GAR transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">GAR transformylase 2</fullName>
            <shortName evidence="2">GART 2</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Non-folate glycinamide ribonucleotide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Phosphoribosylglycinamide formyltransferase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">purT</name>
        <name evidence="5" type="ORF">D3H35_07285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24829"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (formate route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.21" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04383">
        <property type="protein sequence ID" value="RIE04383"/>
        <property type="gene ID" value="D3H35_07285"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043815">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase 2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01643">
        <property type="entry name" value="PurT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005862">
        <property type="entry name" value="PurT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01142">
        <property type="entry name" value="purT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="4">
        <location>
            <begin position="111"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="2">
        <location>
            <begin position="14"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="2">
        <location>
            <begin position="355"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>N(1)-(5-phospho-beta-D-ribosyl)glycinamide</name>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="152"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="187"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>N(1)-(5-phospho-beta-D-ribosyl)glycinamide</name>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>N(1)-(5-phospho-beta-D-ribosyl)glycinamide</name>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="386" mass="42122" checksum="C3FCB5D600EDAD45" modified="2018-12-05" version="1">MYATKKIMLLGSGELGKEVIIEAQRLGIETVAVDRYEGAPAMHVADRSYVIDMLDRAAVRELALREKPDLIVPEIEAIATAELLALEEEGFRVIPTARAARLTMDREGIRRLAAETLGLPTAKFQFADTFEEFGAAAREIGFPCVVKPLMSSSGKGQSVCRNEEGLERSWAIAMEGGRVQQARVIVEEFITFESEITLLTVRTESGTLFCEPIGHIQQDGDYIESWQPHPMSEAQIAEAKRIAGVITDSLGGLGLFGVELFLAKDKVYFSEVSPRPHDTGLVTLVSQNLSEFALHVRAILGFPIPEIVVVSPGASRPLKAEAEFASYRVEGVGDALSVPMTQVRIFGKPVTKPGRRMAVTLSSADSVEEARARAKQALDKLRIIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP88</accession>
    <name>A0A398CP88_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_12975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01717">
        <property type="protein sequence ID" value="RIE01717"/>
        <property type="gene ID" value="D3H35_12975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="70"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="276" mass="30316" checksum="E3BC5B5B45DF13AA" modified="2018-12-05" version="1">MTSKWKAAGATSFATLLMIVFLFPVYWMVKTSITPITELYHNPPHLFPVKATFESYINNFVRNQDMLGYIGNSVIISVGTMLLTIVLAVPAAYALSRLKIKGKSIIMILLLSIQMLPGIMMAMPLYIMFSKVGLIDNFIGLIFANLIHALPFAVITLRPFFLSLPGGLEEAAMIDGCNKFTSFTKIILPLVTPGLLTVSVFCFLFGWGDFIFALTLTSGDAVRPLTLGLYRFIGQYGTEWNNLMAVATLAALPIIIIFVSMQKYVVGGITAGSMKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPB1</accession>
    <name>A0A398CPB1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_tran_28_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03149">
        <property type="protein sequence ID" value="RIE03149"/>
        <property type="gene ID" value="D3H35_15910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_tran_28_C" evidence="1">
        <location>
            <begin position="87"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="239" mass="26142" checksum="78D0DBAAB53225B4" modified="2018-12-05" version="1">MGPSGRRQILCCYRGYGRAASKSRHNSRAGSCNGHTDPVIVRSRESARIGRLPLRTRTLSSDRACDGRGYGALSGIRAAIRELTAGGKAQAAIVCGRNRLLEEELRRYYNGDSHISVLGFIDRIDELMGLASCIVTKPGGLTLSEAICAGIPIVLYRPVPGQERNNALYLQNKQAAVVCRTSSELLTAMTGILELPSLRLHLQSAVRKLRQENSSDRICLDILRQLNIMEEVSETPIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPG2</accession>
    <name>A0A398CPG2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_18110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02598">
        <property type="protein sequence ID" value="RIE02598"/>
        <property type="gene ID" value="D3H35_18110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="4">
        <location>
            <begin position="599"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="3">
        <location>
            <begin position="691"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="941" mass="106018" checksum="790264DA30FA7F09" modified="2018-12-05" version="1">MEISGLETEMVENAIDFEKATVDSDMKKLAIFLLLAALAVTSFSAYRIQQNGGLSSGPWERDTVLGNLSRAVDATNGSLAVISQSRQEVDKVSSDGKLEARITHQGSKSVSRRNFTDVAVDGEGRIFVLDTVLDAYGLYVTEEQIIRYDSNGKSAETLYSWKGNGQSKRVGQLKGLQVQGESLFFFVSETDRIALMEIPLSGGNAKETFKFSLPVNRYLSEVIGTQPGQIYYTTKRGAIFLVAENGDSRIVYPLPTMDRTRKNFPEHLSLDPSGKLIFIDRLLNAVTSMEPNKPNSLKVVVEGVSLETAAPGAESYEIMDVDWTAGGGLAVVLNDALLRYDEGGRLAGVQSKFSYERSVITGKWLVWIFGAASAALLVFSLRLVFVHVMNRRFSLFFKMVFITVPIVVICMILLSNFIYNSFSARMEVEMQRELSLLARNGQHLIDGDKLVNMHSPQEYRSADYEAVRKNMNFLFEGEDSADRQGLYSTLYKYEDGQLYILMDDDDGVNMFKPFETSEDNLAVLQEGVVRSGQWEDANGKWMYAIGPVYNSDGQVVGIYETGRDLNVLYQANRKIYKNIIENIVYITSGLLVVILLATFLMLSSVRKLRRSVMAMADGNWDTEVSIRSRDEVGDLGVQFNRMARYIRQYIADITQFSEASYRFVPQQFFKSLGKKGILDIRLGDQVQQNMAVLVANIRGFHQLSQKLTPKENFNFMNSFLRRFGSQVRKEDGLISKYLGAGFMALFPGYAEEALRTAVAIRRDLVDYNEGRRRAGYEPVEVGIAIHKGPLMLGIIGEELRWESNVISDDVHLTATLEKLSDDLGASILVTRAFFEQLREPERFRHRTLGRITPEGQGEAIELIDIYEGDSEQTRQLKDRTKPLFERGLQLCQEGRFYDARETFVEVIKQNRLDKAAKLYFYLCDEYYQKGTGSGWNGTLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ09</accession>
    <name>A0A398CQ09_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_21805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01064">
        <property type="protein sequence ID" value="RIE01064"/>
        <property type="gene ID" value="D3H35_21805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="195"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="266"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="552" mass="59184" checksum="05728EAAE2B6394E" modified="2018-12-05" version="1">MGLYIAQKNAAFHEFEQIGDKLRTQAQANVSLILPMAQAFDANQEPPADEMEILKKLLDGMTDPDLLTNSYYLSANKIDKDGTAYLKTLQVSQSLTDKQFVAGKEFPASDVLLKAFDESAKGHSELTASYQDELGSWITYIAPVQDEDGDPVAYFAIDFDYDKVEKQMSTLLLRAVLFGIIVALIAIGLVIFLIRMAVRPLRLLAANAKEAAKGNLTVSVPVTNGNEIGQASASFNEMIGSLRELAINIKQTSAEVSVSSRSLKETASQTAQATNEITEAIQNVATGTETQLGSSQECQRAMSEMAGGIQRIAESASVVSDLAVNTADLAAEGDTVITRTVKQMQTIESHVFTASDSMRELNDSSDKIEDILSHISEVANQTNLLALNASIEAARAGEHGKGFAVVAHEIRKLAERSKESSEEIVAILHSIGIRSKQVAASLAVTAEETRIGSELAVTSGESFRSILLSVKQVSEQVQEVSASSQQMSASSEQIAASLEELERIAQTSSAHSQQVAAASEEQLASVEEIASASEQLRSMAGDLNEAVSRFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ63</accession>
    <name>A0A398CQ63_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CidA/LrgA family holin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_12315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03439">
        <property type="protein sequence ID" value="RIE03439"/>
        <property type="gene ID" value="D3H35_12315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005538">
        <property type="entry name" value="LrgA/CidA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33931">
        <property type="entry name" value="PTHR33931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03788">
        <property type="entry name" value="LrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="126" mass="13574" checksum="81C3E3712FDDB03C" modified="2018-12-05" version="1">MKAVKNKLVAALQISILYAFALVLDQAAEACKLPIPGSIIGMALLFALLRTGAIKLRWIEAGARWLIAEMLLFFIPATAGIVQFKHLLLSNGLSLLLVIVVSTFVVMLTAGMLVDRIGKRKEQAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQI9</accession>
    <name>A0A398CQI9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cu_amine_oxidN1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_07550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04430">
        <property type="protein sequence ID" value="RIE04430"/>
        <property type="gene ID" value="D3H35_07550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017252173" description="Cu_amine_oxidN1 domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="2">
        <location>
            <begin position="50"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="429" mass="47636" checksum="BEB915E66235559F" modified="2018-12-05" version="1">MRKTVRIVALFLVFGIMALPRLVGAQPASPASVYLDGSPLSFEHEVVEVNGYNYVPFRNLFEALNVTIDWNPSTKTIIGQSNSDTLELQIGSLTALVNGKSVILDAAPFIRNGASYVPLRFASQSLGLLVQWYSAEKVIRLSTNYVTLNIKNVLGDKVTNEEVSVRLLAKEPQQEPYSLDHRQATMEMTGLLPEREYEVSVQVKDSLRFIQPKPFTFVYKAGMQVLPDLMLEDAPSDLLRGTVTDEDGNPVPNLTLMVLDENAGEETLNKVNTLVYPDEKGRYSLPNLIAGHRYNISVQKLSNYRAGEPYPDHAYPWVPPFTYKPGMKSLPSIVVPKAQWVGNIALSDGIISAIVFLNDEDGTQISHSPYYGGKYVLGGMVKGQKYRISYMLIRLSSAAPLDQSPLWSAYWFTYDPAAPAPDLPITPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQT2</accession>
    <name>A0A398CQT2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000026">
        <property type="protein sequence ID" value="RIE04520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04520">
        <property type="protein sequence ID" value="RIE04520"/>
        <property type="gene ID" value="D3H35_05810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="120" mass="13668" checksum="7D6A2C25E3AB48F3" modified="2018-12-05" version="1">MDYSKMCPKYESAADLLGKKWTGLIIRVLLGGPKRFKDIKGQIPDMSDKMLTDRMKELESLGILTRTVYPEMPVRIEYELTEKGRGLEEVIQSIQNWARNGCSTKPKRPFTGTAFLLANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQV2</accession>
    <name>A0A398CQV2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_05455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04540">
        <property type="protein sequence ID" value="RIE04540"/>
        <property type="gene ID" value="D3H35_05455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="10"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="383" mass="44219" checksum="DF7F62792592B57E" modified="2018-12-05" version="1">MASEGGAGMNAILLDDEPLALRSLAFQLNRFEDMNILGTFSFPADAIVAAEKLRPDVAFIDIDMPDMNGIQVAEKLQDIDDSMVIVFVTAYEEYAVKAFELNALDYVLKPVQPSRLERTVQRLLEDNRLHKESRAVKEDTKAERVIVHCAGSMNVIGRDGEPLPWRTAKSRELFAYLVFKRGQPVRKETLLELLWPDTDEKKGFTQMYTTIYRLRKTFDAAGLSIRLLNSGDGYWLRIEDLAVDLLEWEEAIAQLPALSAESADAYQWQLDYYPGDYLDEHDYVWSEGERQRLRSLCYRQAVQLGRFWTSQGFGKKAADTYERLQRQFPFAEEIYEALIELYANEGHYSLAQRQYELLSDMMRSEYDSEPSEEAKKIYSRIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQZ6</accession>
    <name>A0A398CQZ6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe/B12 periplasmic-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04580">
        <property type="protein sequence ID" value="RIE04580"/>
        <property type="gene ID" value="D3H35_05715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="228" mass="25934" checksum="0BF8009E66D1CB10" modified="2018-12-05" version="1">MAVKEYELVFASQWEELERAKPDLIIGDFYHFSFRDRFQGIAPVSSLLADRSWVNNYRKMAEILGSSEEAEQAVNRLAMRVAAARSLLAARMGGKSIVVLQVTNHNIRIQGATDHPLSELLFGELGLQPGRTEQSNAKRLELQPEWLPQIDTDYALVFQNHIRAGSETIYDRMCGTHAWRSMRAVQNGNVLLIPNWFKMSWSPIGREEIIDELLMMTDTLPEAAKESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR29</accession>
    <name>A0A398CR29_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplB</name>
        <name evidence="8" type="ORF">D3H35_02255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE04993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04993">
        <property type="protein sequence ID" value="RIE04993"/>
        <property type="gene ID" value="D3H35_02255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="7">
        <location>
            <begin position="124"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="276" mass="30358" checksum="DF047B0C5CF899DE" modified="2018-12-05" version="1">MPVKKFNPTTPSRRQMTMSTFEEITTSTPEKSLLAPLSKRAGRNHQGKLTVRHHGGGHKRKYRIIDFKRTKDGIPARVATIEYDPNRTSYIALLNYADGAKTYIIAPKGLKVGDEIMSGPTADIKVGNALPLENIPVGSVIHNIELKPGKGGQLVRAAGTEAQLLGKEGQYVTIRLASGEIRRILRQCRATIGTVGNQDHELINIGKAGRNRWLGKRPVVRGVVMNPVDHPHGGGEGRAPIGRKSPMSPWGKPTLGYKTRKKKKASSKYIVRRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRD1</accession>
    <name>A0A398CRD1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SMP-30/gluconolactonase/LRE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_02880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05092">
        <property type="protein sequence ID" value="RIE05092"/>
        <property type="gene ID" value="D3H35_02880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGL" evidence="2">
        <location>
            <begin position="19"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="302" mass="32776" checksum="FC441FD723AADF67" modified="2018-12-05" version="1">MKNADEWEPVALALPPSSLGEGPCWDEGTGTLLWIDITSAKVCRLDPGSGKVESYPAPEWISTIVPCAGGGWIAAAYHSLYRWEPGSSVFEECLRLDGLPAHVRFNDGKAGPDGRLWFGTMDMNGSLPLGSLYRIDRDLSVFEALRGVTCSNGLDWSLDGREMYYIDSAVREVRAYAFDDKQGELGERRTAIRLEEGTNGVPDGMTLDSEGMLWIAQWGGSRVARWNPAGGSLLTEVRLPVLQPSSCAFGGERLQTLYITSASDGLQAAELNAYPRSGALFAVDTSAAGLSGRRPYSFDMAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRF9</accession>
    <name>A0A398CRF9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03075</name>
        <name evidence="3" type="ORF">D3H35_03100</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05123">
        <property type="protein sequence ID" value="RIE05123"/>
        <property type="gene ID" value="D3H35_03075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05126">
        <property type="protein sequence ID" value="RIE05126"/>
        <property type="gene ID" value="D3H35_03100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="151" mass="17851" checksum="CEAF3A54553B95EE" modified="2018-12-05" version="1">MTQYRVLDEKICLSAIKYLWNNEIVGYQISRTMNPLVLETFRKSFDKHKDVTGLIVHSDQGSHYTSRAYHDMLPQVGAQISMSRRGNCYDNASMESFFSHLTVEALYPYDIRSIDEAQRRIKEYIRFYNEDRAQRKLNKLTPVEYRNQLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRH7</accession>
    <name>A0A398CRH7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_03085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05142">
        <property type="protein sequence ID" value="RIE05142"/>
        <property type="gene ID" value="D3H35_03085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="172" mass="20805" checksum="4405D91183C68F04" modified="2018-12-05" version="1">MELEINLKQSYGVIKHSMSTENIADLISLFIEKDSIALFSFYERNMHLFDVNTQKFISDRFVFVNSEWVLPWEESIPHWDEPDQTPPKIIWFSVTQKEDMIKAIEIDYLFRCIVIKQGEEFKRCTNVLFHQEYYSSVDEEDYEYYLGFTNKDFFFVNSLDEVKERFEIRLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRM4</accession>
    <name>A0A398CRM4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0145 protein D3H35_04900</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_04900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0145 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04810">
        <property type="protein sequence ID" value="RIE04810"/>
        <property type="gene ID" value="D3H35_04900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00338">
        <property type="entry name" value="UPF0145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="PTHR34068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="105" mass="11198" checksum="B958C4B6E1A4FB01" modified="2018-12-05" version="1">MLVTTTPNVEGYRITQYKGIVNGETIMGANIFRDFLASITDVVGGRSGSYESKLKEARDIALSEMVAQAQQLGANGIVGVDIDYEVVREGMLMVAVSGTAVLVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRN4</accession>
    <name>A0A398CRN4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphonate ABC transporter ATP-binding protein</fullName>
            <ecNumber evidence="6">3.6.3.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">phnC</name>
        <name evidence="6" type="ORF">D3H35_01445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.28" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05212">
        <property type="protein sequence ID" value="RIE05212"/>
        <property type="gene ID" value="D3H35_01445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015416">
        <property type="term" value="F:ABC-type phosphonate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03256">
        <property type="entry name" value="ABC_PhnC_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012693">
        <property type="entry name" value="ABC_transpr_PhnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02315">
        <property type="entry name" value="ABC_phnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0918">Phosphonate transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE05212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="263" mass="29154" checksum="D1DA2126CF5BC98B" modified="2018-12-05" version="1">MTMTILEFKQVSKQYDTNTKALSHVNFSVREGEFVSIIGPSGAGKSTLLRCINRMIDVNAGEIAFDGCDVTKLKKSELKKVRTQIGMIFQHYNLVNRLSVIENVLHGRLGYKSTLAGMLGVYSEEEKRNAYSILKVLGLEEQIYKRCDQLSGGQKQRVGIARALIQNPKLLLCDEPIASLDPNASKIIMDHLKNISRTMGITVIANLHQVEAAMNYSDRIIGVNKGSIVFEGAPADMSRDKLRTIYGAELEEQSVEVGGRYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRR8</accession>
    <name>A0A398CRR8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellar assembly factor FliW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fliW</name>
        <name evidence="4" type="ORF">D3H35_14960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with translational regulator CsrA and flagellin(s).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02061">
        <property type="protein sequence ID" value="RIE02061"/>
        <property type="gene ID" value="D3H35_14960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01185">
        <property type="entry name" value="FliW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003775">
        <property type="entry name" value="Flagellar_assembly_factor_FliW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024046">
        <property type="entry name" value="Flagellar_assmbl_FliW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39190">
        <property type="entry name" value="PTHR39190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02623">
        <property type="entry name" value="FliW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141457">
        <property type="entry name" value="SSF141457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="148" mass="16792" checksum="12A93FADF7B5D996" modified="2018-12-05" version="1">MCLGEGRFMIQLLHERVVQFKGSLLGFEELNEFSITAVEEDSPYAYMQSLQDESIGFLVATPFIFHPDYTFEIEEKDKTLLELKSQEEVAVFNLVTIKEPFTQSTVNLLAPVIINLTNGQARQVVLPPKSNYGTSELLFREIPEKSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRZ1</accession>
    <name>A0A398CRZ1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04960">
        <property type="protein sequence ID" value="RIE04960"/>
        <property type="gene ID" value="D3H35_03215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="74" mass="8359" checksum="4BA5E8F00C9697D2" modified="2018-12-05" version="1">MTLTEEQTEKLLKQVNKAYNTEINDILLTALGLAIGEWNDSKQAAIELEGHGREEIGHEVDISRTVGWFTTQYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS01</accession>
    <name>A0A398CS01_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_03265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04970">
        <property type="protein sequence ID" value="RIE04970"/>
        <property type="gene ID" value="D3H35_03265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="140"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="146"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="643" mass="73143" checksum="A6A4FD7F3045508E" modified="2018-12-05" version="1">MTQERFVNDPFVSGERMYKTGDFVKWLPDGNIEYLGRMDQQIKFHGYRIETQEIEARLLDIEAIREAAVLLVTQNESTYLCAYYSADRQLSYNELRANLSEVLPVYMIPTSFMKMDAIPLTPNGKIDRKALPEPIGREIKTTSDYISTSRTEQTVMTEIQELLNLSNIYPDRNFFELGGDSIKALILINRLHGSGILLETKDIIYSNSISDIVSSVKHADMSFVQSQFSGIVKKTPAMEWLMARGLPYINQRHQSVFLQLQVPIEGSELKRILLEIIRHHQLFRIRLDDDTGDFYLDNSQPPLEPEIDLITLSDYGLAELSKIMEEARVRSTSSLVLDRGNVVQACMFAGEDGQIAHLMLSAHRLVMDLDSWGILSKDLSTMLRLHLNGEAARLAAPRSIDLQPANGNQGSGKRTYDSLGIDANELLEANHAYHTRTAELLIIALVLTMHERLSPLAFGVEIDLGERGGSVTEDEVSGIGCLAPIYPAVFQVHSTDLHDQIKEVKEQIRGVLKDGQSLGGLQERLEQFEEPNRRLVGFRYGGDLDAIFENDIFTLMRFEEGFENSHPRFLDFRFVFRHRTLQLDVHYNPAELADFAVNEWVEVLVRNMKKIILHCAMKKTSEFTPSDFKMMKISQSDLDLLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS27</accession>
    <name>A0A398CS27_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D3H35_15615</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02171">
        <property type="protein sequence ID" value="RIE02171"/>
        <property type="gene ID" value="D3H35_15615"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012744">
        <property type="entry name" value="Nitri_red_NirB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017121">
        <property type="entry name" value="Nitrite_Rdtase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037149">
        <property type="entry name" value="NirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02374">
        <property type="entry name" value="nitri_red_nirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="12">
        <location>
            <begin position="4"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin_C" evidence="13">
        <location>
            <begin position="316"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="11">
        <location>
            <begin position="418"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="11">
        <location>
            <begin position="482"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="10">
        <location>
            <begin position="557"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="9">
        <location>
            <begin position="627"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE02171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="808" mass="87815" checksum="92BF448F14AE9B23" modified="2018-12-05" version="1">MKKKLVLVGNGMAGVSCVEQMLKLAPNRYDITIFGSEPHPNYNRILLSSVLAGDADMQDIVINDWSWYEENHITLHTGQTVTRIDQQNKLVSTDGGISVPYDELIIATGSLPFMLPLPGADKEGVIAFRDIKDCETMIETAKKYRKAIVIGGGLLGLEAARGLLNLNMEVSVVHINPYLMERQLDEPASIMLRKELESQGMRFLLSKNSESILGKKRVTGLRFTDGSEEQADLIVMAVGIKPNVALAKASGIEVNRGIVVNDYLETSAPNVYSVGECAEHRGIAYGLVAPLYEQGAVLAKRLAGAETKGYQGSVTSTKLKVSGVNVFSAGMFTDAPDTRAIRVQDEIGGVYKKIVLRGGKVIGSVLFGDTSDGSRLFAMIRSEEDVTGREKEVLLGAGGGGSAKSGVELVASMADDEIVCGCNGVSKGAIVQAINEKGCASVNDIKACTKASGSCGGCKPLVADVLTYVLGADGVKTVKEGICGCTTLGRDEVVESIKAMHLTTSKEVMNVLGWNNAEGCSKCRPALNYYLGMVWPEEHEEERESRFVNERNHANIQKDGTYSVVPRMYGGVTTPADLKKIAEVAVKYDVPLVKMTGGQRIDLLGVKKEDLPKMWADLDMPSGYAYGKALRTVKTCVGSTFCRFGTQDSIQMGIDLEKKFERLNTPAKVKMAVSGCPRNCAESNIKDFGVVAIDGGWELHVGGNGGTKLRATDLLCKVKTEEEVLEWAGAYLQYYRETGKYNERTSEWVERVGLDTIKAALEKQEDRAELVERIEKTLSLTKDPWKEIIEKQELNRNFVPIAGEPAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS66</accession>
    <name>A0A398CS66_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05393">
        <property type="protein sequence ID" value="RIE05393"/>
        <property type="gene ID" value="D3H35_00995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="180" mass="19538" checksum="DDFB5444E4D1FF43" modified="2018-12-05" version="1">MRRELGFADGDRVLFCIRRLVRRMGIDRLIRAMAKVKSDVPGAKLVIAGDGTMRSELERLTAELGLGDSVRFVGRVSNEDLVRWYQAADFSIVPTVTLEGFGLVTVESLACGTPVLGTPNGGTKEILEPFHPELLFRDDSPEALAYTISAVLRGTSSCRIERPAGSTSCSATRGSRLPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSE7</accession>
    <name>A0A398CSE7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_18890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKC lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02717">
        <property type="protein sequence ID" value="RIE02717"/>
        <property type="gene ID" value="D3H35_18890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008844">
        <property type="entry name" value="Spore_GerAC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05504">
        <property type="entry name" value="Spore_GerAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="170" mass="18642" checksum="83C4ACE613E61660" modified="2018-12-05" version="1">MDFFLRYLQFREHAYAYVSEGEAETVLGLEPLLERSSSEELREMGNMKIGMLVTLKNLARMVDGDSRSAVLSNISPVVSKNGNRPAAKTTALNHLALFEEDKMIASLQEPESRGLLLIRNEMETINFSFPLKGTEGEVSINLLDASAKLIPRIGSDGNGGCASTCAYPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSQ5</accession>
    <name>A0A398CSQ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Renal dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03788">
        <property type="protein sequence ID" value="RIE03788"/>
        <property type="gene ID" value="D3H35_09550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039498">
        <property type="entry name" value="NTP_transf_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14907">
        <property type="entry name" value="NTP_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="392" mass="46025" checksum="9E3D64482216A2B2" modified="2018-12-05" version="1">MMARSSTDIDGLPQELRLLLRMLSTENGGEPLSAEAAPYEDIDWGRFQRLAMHHRVYPSLYAILKKAALPWVPQPLIQDLSREYKKNTFRMLRLTGEMERICALLADQGVRSIVLKGPPLARELYGDVSLRTSKDLDIMIPIDDVDKTDRLLTQLGYKCVDFVPNILNGWRWRQHHAGYDHPDLPINLEIHWRLSPGPSREPGFEELWERRRISEMTPTPIHYLGAEDSFLYLVTHGARHGWFRVRWLGDIDILACRHADEWAKIEALMDRYQARDMVGQSLYLISALWSTPLTPDMRRYSSGTKAQTLGRQALYFIREMVENPPPELERKHKQYLFSLKSFRQKILYALSFLYPYPKDVETLPLPKPVHFLYFPLRPFLWMWRKARKHAWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSZ0</accession>
    <name>A0A398CSZ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_20235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02937">
        <property type="protein sequence ID" value="RIE02937"/>
        <property type="gene ID" value="D3H35_20235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="372" mass="42393" checksum="038E76AD1346BAA5" modified="2018-12-05" version="1">MFNVVIVEDEKPILELMKVVIGKNPLYNIVGAFSNPLEALAHLPALQPDVAFLDVEMPKLGGMELARKIGECCERTRIIFATAHKEYALEAFNVYAFDYILKPVTPAAVERIAARLTKLDRPISAPAAVKAARQVSLSCFGGFEVRNAQDELIHWPTRKTEELFAYFLCYSNQDVGKWRLADDLWPEMAEERAASNLYNTIYRLKKTVQSQEIGMDIVKTNDGYMLKTLHADYDLLEFQRAVSALKNEAEDIAELERLCSLYRGPLLEHKDYMWKIQLEAGYDKQYRKLALQLIRLYMSGEEWSKAERQIDICLTAYPLNEDMHGLLIDIYAASGRKERIAAHYVGFKAHYREELGIDPPAELSGKVAAYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT13</accession>
    <name>A0A398CT13_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asp23/Gls24 family envelope stress response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04399">
        <property type="protein sequence ID" value="RIE04399"/>
        <property type="gene ID" value="D3H35_07385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="119" mass="12938" checksum="F50E53FB79EAA055" modified="2018-12-05" version="1">MPIQLATENGKIDVADQVVSVIAGSAALDCYGLVGMASRKGLKDGIAELLGRENLSRGIEVRREGEQVHLDLYVIVSYGTKISEVAHNIQSKVKYVLDEVVGLKVDDVNIYVQGVRVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTL7</accession>
    <name>A0A398CTL7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Genetic competence negative regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04619">
        <property type="protein sequence ID" value="RIE04619"/>
        <property type="gene ID" value="D3H35_03755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038471">
        <property type="entry name" value="MecA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008681">
        <property type="entry name" value="Neg-reg_MecA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39161">
        <property type="entry name" value="PTHR39161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05389">
        <property type="entry name" value="MecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029008">
        <property type="entry name" value="MecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="201" mass="22799" checksum="E25771F3D766B765" modified="2018-12-05" version="1">MRMERLSTDKIRIFLTFDDLTERGIQKEDMWREIPKVHELFSEMMDQAYNELGFDASGPLAVEVFAMPAQGMVVIVTRGKLERDAERATEDEEQEEEVYEMEVTLEQSEAIIYRFRDIEDAIGAAKTLIGQLTGEGRMYRYQDQWILCFDPAGLEAAGYHALIAVLAEYGEATSVTPAVLEEYGQIIIASDAVKVLAEHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU36</accession>
    <name>A0A398CU36_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04789">
        <property type="protein sequence ID" value="RIE04789"/>
        <property type="gene ID" value="D3H35_04760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="36"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="257" mass="29384" checksum="5DD6ECD2D4347D54" modified="2018-12-05" version="1">MRITFLGQGDSLGTPRVYCECEVCEEARSTGRNRRFRSSLWIETEGEEPLLLDCGPDFRTQMEQLGERFVGKGLLTHAHFDHIGGMVEWADACRWRDSYADVFGPREVLDEVRARFPWLESRLRMKDNDGGMSYGEWTIYPWKVNHGKNGYSYAYRFEHSATGRAWAYCSDSINLNAKEKEPLNGLNLLILGTSYVVEPFPMETRSLYDMKEGLLLVAEVGAETALFTHLSHDVDVRRNYGLPNHVKLAETGMKVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUK6</accession>
    <name>A0A398CUK6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04949">
        <property type="protein sequence ID" value="RIE04949"/>
        <property type="gene ID" value="D3H35_03160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="2"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="300" mass="34031" checksum="73AE31A564D71320" modified="2018-12-05" version="1">MQYKDYAVWQQAFMQSEAMKRQETYWLETFSGELPVLEMPTDYPRPAVQSFKGDQIQFVLDGELSAGLNRIAAETGTTLYMVLLAGYSALLSKYTGQEDIVVGTPIAGRPHADVENIIGMFVNTLAMRSRPAGEKTFTAYLQEVKEVALQAYEHQEYPFEELVEKLNVRRDLSRNPIFDTMFSLQNMSEEETEIEEMRFSPYGFEHSASKFDMSLTAVETGSEIGLSLSYCTAIYTKETAERLGRHYVALLRDISSQTAKQLKAIELLSAEEKRQLLHAFNDTKASYPADQTIQGCLKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUQ3</accession>
    <name>A0A398CUQ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tagaturonate reductase</fullName>
            <ecNumber evidence="4">1.1.1.58</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_20715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19661"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:61381"/>
            <dbReference type="EC" id="1.1.1.17"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.58" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03021">
        <property type="protein sequence ID" value="RIE03021"/>
        <property type="gene ID" value="D3H35_20715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008926">
        <property type="term" value="F:mannitol-1-phosphate 5-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009026">
        <property type="term" value="F:tagaturonate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol_dh" evidence="2">
        <location>
            <begin position="28"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol_dh_C" evidence="3">
        <location>
            <begin position="156"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="439" mass="49548" checksum="BED2DDBDFF387A1D" modified="2018-12-05" version="1">MSASSVRQAEAGCFSASGRIVHVGYSGLENGETVERKEVVNVFRELVDPYSEWKRFVALAENPDLRVIVSNTTEAGLKFRSEALAEGKPLESFPGKIAYLLYRRYAAFQGSTEKGLLLLPCELLERNGDELLACVLRHAEEWRLPGEFSEWVRTSNRFLNSLVDRIVTGYPGDEQAQSWSGEWGYEDSEMNTAEPYHLWAIEAEPELDNVLPLRQAGLNVHWTRDLRPYQQRKVRILNGAHTLMTPLGILSGLTHVRELMEHSELGSFVVRTVENEIVPSLPYPREEMDDYAAAVFERFRNPFIRHRLSDIAMNSISKFKTRLLPTLAHYGKQHKPIPDGLARAFAALLRYYNVRATGNGFIGKTFAGAEYAVRDDESLIGLFEEIWTDAERLKQPPIRIAERFLRLEAAWGIDLAKVDGLAAGIAAQWTKMGGAATYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUW7</accession>
    <name>A0A398CUW7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AI-2E family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_21160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03091">
        <property type="protein sequence ID" value="RIE03091"/>
        <property type="gene ID" value="D3H35_21160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="378" mass="42734" checksum="89658188C6F03CAB" modified="2018-12-05" version="1">MFSLYQKYWRTAFDIAVIALTVWLVMYLFSYLYNLATPVFLSFIVFWCIEPLAKKLQKLGIRKSIGAGISVLFFMLIIIALFVGIGFMFTYQIGQLMDKLPTYQTMFQNQFASISAELKDRFADLPEGFDTKLAEVVNNITKQGTTWAQQFLKWLIGFLTSFSSFILNFSIAVVLAYFLSVEIDTWKRLGTERAPKTLKVALDFLRNNVFWGIGAYLKSQAILISITFAVIFVSLLALGVNNAFAIALLAGILDVLPLLGVNTLFIPWVIYLFIVGDTSLAIWLTGLLVFVTLTRQILEPRITGQTIGVSAFTMLAFMMVSLSLFGVAGLILAPILMILLKALYDQGYFHRWIRYPKEEFTVAPFEPQPARPDLEENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV08</accession>
    <name>A0A398CV08_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_02990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05109">
        <property type="protein sequence ID" value="RIE05109"/>
        <property type="gene ID" value="D3H35_02990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="222" mass="25888" checksum="F3D89F012600F1E8" modified="2018-12-05" version="1">MTICFHCTKLGFVMKQHSLSVADIESPEVLIVGYKRQKELACGECGRVLFPEEMYFEDERDYESFVRKTLDAIAEKISAQLDYCSRCDGYDIERSIYLVNKGEARDLIKEGAYGQTVWEFMSDNDIPERYFNEIRKRLCCRNCGRRDLEIGQRVYSEDDMDSFWGRKLISFAFSYGINIGSADLEEFRTHLYYRPMLAMQHEVGGKYSQPFNGNSKRAPTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV10</accession>
    <name>A0A398CV10_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03707">
        <property type="protein sequence ID" value="RIE03707"/>
        <property type="gene ID" value="D3H35_10450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="84" mass="9626" checksum="8E640DB57B71C484" modified="2018-12-05" version="1">MAEYSESRQFGLRRSMQIAMLGWATESDVSRSLQIAMWGWVADSDVRRSVQITMLGWATESDVRRNVQITMLGWVADSDVRRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV56</accession>
    <name>A0A398CV56_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02914">
        <property type="protein sequence ID" value="RIE02914"/>
        <property type="gene ID" value="D3H35_20085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="80" mass="8704" checksum="5DC760B9A68ECD62" modified="2018-12-05" version="1">MAKRKNGTLARLSEGDSTDKRKNGTLARLSEGDKTAKRKNGTSARLSEGDNTDKRKNGTLARLSEGDNTDKRKNGTLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVL4</accession>
    <name>A0A398CVL4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_05690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04578">
        <property type="protein sequence ID" value="RIE04578"/>
        <property type="gene ID" value="D3H35_05690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017482957" evidence="5">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="79" mass="8540" checksum="18A300CB3F0EBEA9" modified="2018-12-05" version="1">MIRKPFAAPVVMLLLCAASVVASAALGKMALSPLEAIRGLLGIGAEDHEMVIRNLRLPRILVALLAGLHWPLPERCFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVR9</accession>
    <name>A0A398CVR9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000006">
        <property type="protein sequence ID" value="RIE05409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05409">
        <property type="protein sequence ID" value="RIE05409"/>
        <property type="gene ID" value="D3H35_00540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="127" mass="14215" checksum="496845180338F280" modified="2018-12-05" version="1">MMTLRNVRENEFDDLMALWQFAFQIQMPAGASGKGARIVPCRQSLGLFDENGRLLTNLSILPLEVWIHGVRMKMRRVASVSSWPDARRQGSDQAASPCAPKKCAKRTDDQHAASVLGSLLPQIRYEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW02</accession>
    <name>A0A398CW02_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03391">
        <property type="protein sequence ID" value="RIE03391"/>
        <property type="gene ID" value="D3H35_11995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="97" mass="11571" checksum="D7EC2A70330C9985" modified="2018-12-05" version="1">MILEVASLQVKPGLSASFEADFRQASRIISSMKGYIGHELQKCMEHENKYILLVKWESLEDHTIGFRQSERYQEWKKLLHHYYDPFPTVEHYEIVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW13</accession>
    <name>A0A398CW13_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoesterase</fullName>
            <ecNumber evidence="2">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_12060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03401">
        <property type="protein sequence ID" value="RIE03401"/>
        <property type="gene ID" value="D3H35_12060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="167" mass="18582" checksum="ACFFF2D23F9D3A9B" modified="2018-12-05" version="1">MKIVVVSDTHMPRMAKGLPATLTKELRGADFIIHAGDWTDLRVAEELEKHAPLDGVTGNNDGHDVWRKFGWKKTISFGEVKVGIVHGHGDGGRMGTEERAIAAFKDEDVDCIVYGHSHIPALREVGGVLVFNPGSPTDKRKQPLYSFGLLEIEGRQIRARHLFYKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXP0</accession>
    <name>A0A398CXP0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_05540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04557">
        <property type="protein sequence ID" value="RIE04557"/>
        <property type="gene ID" value="D3H35_05540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="PTHR11592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="182" mass="20692" checksum="F9BD1F6CF0FE04DE" modified="2018-12-05" version="1">MSNIYEIPTKTLRGEQSDLSAYRGKVLLIVNTASKCGYTKQYEGLQKLYEQYKDQGFEVLGFPSNQFGEQEPGTNEEVEQFCSVNYGVSFPLFDKTDVRGEQAHPLFRFLTEQAPFQGFDQADPAAKGMGDYLKEKLPDYYEGDGIKWNFTKFLVDRNGNVVERFESPVTPAALEPKVKELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ89</accession>
    <name>A0A398CZ89_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2626 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04244">
        <property type="protein sequence ID" value="RIE04244"/>
        <property type="gene ID" value="D3H35_06405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020254">
        <property type="entry name" value="DUF2626"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11117">
        <property type="entry name" value="DUF2626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="78" mass="9267" checksum="E37AFDDB72577406" modified="2018-12-05" version="1">MARMFRVLGFWTLAIALMAYAGDMYEMSLLFFIQSAVFFLFGYLKFSERTYILMFWGYMIVAFLGFTYWSVFEMGLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZC2</accession>
    <name>A0A398CZC2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_05655</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04571">
        <property type="protein sequence ID" value="RIE04571"/>
        <property type="gene ID" value="D3H35_05655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="134"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="134"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="232" mass="26336" checksum="85567F874BACACF0" modified="2018-12-05" version="1">MSRRILIVDDDKEIANLIAIYLRNEGFDTDIAHDGEEAIRKVADQTYHLIVLDVMMPRMDGMEACRRIRETAEIPILMLSAKAEDMDKILGLMTGADDYLVKPFNPLEMIARVKSLLRRTYQYSAQGTTGTDEEGIIRIGGLTINRVTHTVHSEDRQVHLTSTEFGILFLLAGQPGRVFSAEDIFQQVWKEKYFESNNTVMVHISKLRDKLEQETGSKLISTVWGVGYKIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D009</accession>
    <name>A0A398D009_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione hydrolase proenzyme</fullName>
            <ecNumber evidence="4">2.3.2.2</ecNumber>
            <ecNumber evidence="4">3.4.19.13</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase large chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase small chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="5" type="primary">ggt</name>
        <name evidence="5" type="ORF">D3H35_07735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Cleaved by autocatalysis into a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="4"/>
    <dbReference type="EC" id="3.4.19.13" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04504">
        <property type="protein sequence ID" value="RIE04504"/>
        <property type="gene ID" value="D3H35_07735"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102953">
        <property type="term" value="F:hypoglycin A gamma-glutamyl transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="530" mass="58183" checksum="F05A6F062D1A0A02" modified="2018-12-05" version="1">MPKVKRAMVATPHYLATAVGSSILQGGGNAYDAAVAVSAALSVVYPHMTGLGGDAFFLLYDASRKTYRGYNGSGRSSAAASVEYFKSKGRKEIPHRGIESALTVPGMADAWWSVWREGGKLPWHKLIEPAAAYAEEGFPISRNLAEWIAKDESLLSCDPGMKKTYLPGGQVPREGSALLQPELAESLRTLQREGRDAMYTGTLMKRIVEAVRQDGGLLGERDFAEHRGEWVEPLKTRYRGCDVYQMPPNSQGFSLLMMLNMLENMKLTDVPRHSAEFYHLAAEVVKRAFVERDRYLTDPEFNNIPLDKLLSKPFAQELFRTIRMEGAGLGGEAGSASIPMGQDTAYAAIVDEEGNAVSFIQSLYFDFGSCYMAGDTGIILQNRGSFFSLDPSAPNVLEPRKRSFHTLMPGMVARDGKPYILTGTQGGEGQPQTQLSVLTGVLDYGLSIREAIELPRWVYGRTWGSEDDSLKVEPRFEAGVEERLSELGHKVERVREWDGIMGQSQGILIDETGTISGAADPRGDGSVIGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBI4</accession>
    <name>A0A398CBI4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTPase Obg</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">obgE</name>
        <name evidence="7" type="synonym">obg</name>
        <name evidence="11" type="ORF">D3H35_27610</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00516">
        <property type="protein sequence ID" value="RIE00516"/>
        <property type="gene ID" value="D3H35_27610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036346">
        <property type="entry name" value="GTP-bd_prot_GTP1/OBG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015349">
        <property type="entry name" value="OCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09269">
        <property type="entry name" value="DUF1967"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102741">
        <property type="entry name" value="SSF102741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03595">
        <property type="entry name" value="Obg_CgtA_exten"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51881">
        <property type="entry name" value="OCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="10">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="8">
        <location>
            <begin position="159"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="OCT" evidence="9">
        <location>
            <begin position="356"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="165"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="190"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="313"/>
            <end position="315"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE00516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="444" mass="48862" checksum="36081484AD5DB046" modified="2018-12-05" version="1">MFVDKAKVYVKGGDGGDGLVAFRRELYVPEGGPAGGDGGKGGNVIFRVDEGLRTLMDFRYQKHFKATRGEKGRNKTQHGANADDMIVRVPPGTVVIDDDSGETVADLTRHGQEVIVAKGGRGGRGNTRFKTSVNTAPSIAENGEEGQERWVNLELKVMADVGLVGFPSVGKSTLLSVVSGARPKIGAYHFTTLTPNLGVVDLGDERSFVMADLPGLIEGAHTGVGLGHEFLRHVERTRIIVHVVDMSGMEGRDPFEDWTKINDELKLYNPKLAQRPQIVAANKMDMPDSEANLDEFRKRVEETSPGVEILAISSLTRQGIPELLYRVGDLLDSLPEPSALEETAEAGGDEGVVYRFESKDSQDFTIRRENDTFVVESESIERLLRRTQFGSYEAVMRFAKILRTMGVDAELRKRGAKDGNLIRIGEFEFEFFEGGADSYLYEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CC80</accession>
    <name>A0A398CC80_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Beta-galactosidase</fullName>
            <shortName evidence="6">Beta-gal</shortName>
            <ecNumber evidence="3 6">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D3H35_26605</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 6"/>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00766">
        <property type="protein sequence ID" value="RIE00766"/>
        <property type="gene ID" value="D3H35_26605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013739">
        <property type="entry name" value="Beta_galactosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013738">
        <property type="entry name" value="Beta_galactosidase_Trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003476">
        <property type="entry name" value="Glyco_hydro_42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36447">
        <property type="entry name" value="PTHR36447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08533">
        <property type="entry name" value="Glyco_hydro_42C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08532">
        <property type="entry name" value="Glyco_hydro_42M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001084">
        <property type="entry name" value="B-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Glyco_hydro_42" evidence="10">
        <location>
            <begin position="14"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42M" evidence="11">
        <location>
            <begin position="401"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42C" evidence="12">
        <location>
            <begin position="621"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE00766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="681" mass="76838" checksum="6C946AB063034AB9" modified="2018-12-05" version="1">MINASKPKIWYGGDYNPDQWEKPVWDEDMRMFKLAGIDVATLNVFAWAKNQPDEETYDFGWLDEMMDKLHAEGVGVCLATSTAAHPAWMARKYPDVLRVDFNGRKRKFGGRHNSCPNSPAYRKYSTRMAEKLAERYKDHPALLVWHISNEYGGYCYCDNCEAAFRDWVKARYGTLDEVNRVWNAAFWGHTFHDWEDIVSPSSLSEEWYGANGRTETTFQGISLDYRRFQSDSLLECYKLECDAVKTYTPDLPVTTNLMGAFKDLDYYKWAKHMDVVSWDNYPALDTPPSYTAMMHDLMRGLKGGQPFMLMEQTPSQQNWQPYNSLKRPGVMRLWSYQAVARGADTVMFFQLRRSVGACEKYHGAVIEHVGHENTRVFRECAALGEELGKLGDALIDSAVKAKVAILFDWENWWALEMSSGPTIALRYVDEAHKFYDALYRAGIAADVVSAEADLDAYDLVIAPVMYMTKRGVAAKLEQYTRAGGTFVTTYFSGIVDENDLVTLGGYPGELRSLLGIWAEEIDALLPEQRNRIVVKDGAFGLKPEYECSMICDLIHTEGAEVKAVYGDDFYAGMPALTVNKFGDGEAWYVATSPEPSFLQEWLPKLCAERGIEPLVASASEGVETTLRVKDGKEYLFVLNHNAQAASFDLGNRVGADLLTGRELPGGMAELAGRDVLIVRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCT3</accession>
    <name>A0A398CCT3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2071 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00225">
        <property type="protein sequence ID" value="RIE00225"/>
        <property type="gene ID" value="D3H35_29770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018644">
        <property type="entry name" value="DUF2071"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39186">
        <property type="entry name" value="PTHR39186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09844">
        <property type="entry name" value="DUF2071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="242" mass="28218" checksum="4FC9A94FD0FDF503" modified="2018-12-05" version="1">MRTDHRPWPIPSKPWRMKQVWHRLLFAHWPVAADVLAPLIPGKLKLDLFEGQAWIGVVPFHMSGIRLRGLPPVPFTSSFAEINVRTYVTNGHASGVYFFSLDAAHLLAVKAARQFYHLPYYYAEIGMNKENEEILFRSNRIGADDKFQFEGKYRPISEPFVSQKGTLDYWLTERYCLYSHHKDRLFRCDILHEPWMLQHAEAEIFTNTLGNRAGVRLPPTQPLLHYSERLDVLTWGLEEVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD28</accession>
    <name>A0A398CD28_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000051">
        <property type="protein sequence ID" value="RIE00613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00613">
        <property type="protein sequence ID" value="RIE00613"/>
        <property type="gene ID" value="D3H35_27525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="127" mass="14589" checksum="1EFF6F38306E71BB" modified="2018-12-05" version="1">MSPIGIIYSLDYLALRPAYSVRLSIDWERVQNHLDETFGSDSIFYQSQITEAVDKLIDNRVIVIEDDLFVVEGEDEGLTARHEQAVDEVRSMITDAFFTPSLNPIEPEKEDTWDKIEHLAKPLPRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDD9</accession>
    <name>A0A398CDD9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_26310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00713">
        <property type="protein sequence ID" value="RIE00713"/>
        <property type="gene ID" value="D3H35_26310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="86" mass="9757" checksum="88AA5E665B6B9127" modified="2018-12-05" version="1">MQNDFSSIASDYERVVSKFDKLTIQARSCEAIIDMVIQELVVRGHEYDFFMMEDLLNALQRVQEDVLVELSQAAFSTDGSFISTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE52</accession>
    <name>A0A398CE52_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MgtC/SapB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_25405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MgtC/SapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00910">
        <property type="protein sequence ID" value="RIE00910"/>
        <property type="gene ID" value="D3H35_25405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="232" mass="25552" checksum="89AF9B81D0926817" modified="2018-12-05" version="1">MHNPWVIDNVHILIRLLLAVILGGAIGFEREHHNHPAGFRTHILVCMGSTLIMMLSVYGFAEFVGEANVRIDPARLATAVITGVGFLGAGTILFTGKSITGLTTAASLWVVAAIGLAVGAGFNFAAIAASVIVLINLWVFNKIEQRFLKRRKTRVLIIQASTRDQLLDQVCDQLTNKAIITRDMRWANTKSELTDQRQTELHLKIDVPKSIEISKMIADLRRIDGVFAISIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE76</accession>
    <name>A0A398CE76_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="7">3-dehydroquinase</shortName>
            <ecNumber evidence="5 7">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Type II DHQase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">aroQ</name>
        <name evidence="11" type="ORF">D3H35_26485</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes a trans-dehydration via an enolate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="5 7"/>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00745">
        <property type="protein sequence ID" value="RIE00745"/>
        <property type="gene ID" value="D3H35_26485"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="PTHR21272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="SSF52304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="101"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 8">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7 10">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE00745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="145" mass="15462" checksum="BFB12C3BC66CCFD6" modified="2018-12-05" version="1">MPSILVLNGPNLNMLGVREPGVYGAATLSEIEANLRARGSKLGLELRFFQSNHEGALLDEIHAAYGRDDGILINPGALTHTSYALRDGLASVGLPVVEVHLSNIHKREAFRHVSVTAAVCIGQIAGFGPIGYELGLEALSRHLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEL6</accession>
    <name>A0A398CEL6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01153">
        <property type="protein sequence ID" value="RIE01153"/>
        <property type="gene ID" value="D3H35_22360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="150" mass="17023" checksum="8D9B0557C911F7E7" modified="2018-12-05" version="1">MNDLKYVVYIAAEPEDVWRIFVTPEGTKAIFFGCVLDSTFEIGAPYAYKGPGNDGDETVHVYGNVLGFEPNRMMSYTEHPGPSYRENHAELETRVTLELEKVGSCTKLMLINDRWPEGHPSYESTQESWPMILSNIKTYAESGKTLDFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFD2</accession>
    <name>A0A398CFD2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000051">
        <property type="protein sequence ID" value="RIE00602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00602">
        <property type="protein sequence ID" value="RIE00602"/>
        <property type="gene ID" value="D3H35_27470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="135" mass="14981" checksum="D8BA0DF214C17E00" modified="2018-12-05" version="1">MQDGAIKIKVVDFTGEQDEKEKEKWALDFFKENLLRQWFEPTLTPGQVTGGFVQPESLDSVFKRGNELRPAATPAPPRPEFTGSTTAKPESKSPTEGTGNGDAAAATIRRLRNRRPPLRQVRPKEPASPSLPINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFX4</accession>
    <name>A0A398CFX4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="9">CMK</shortName>
            <ecNumber evidence="2 9">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ispE</name>
        <name evidence="12" type="ORF">D3H35_23820</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="2 9"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01400">
        <property type="protein sequence ID" value="RIE01400"/>
        <property type="gene ID" value="D3H35_23820"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF2">
        <property type="entry name" value="PTHR43527:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 9 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="10">
        <location>
            <begin position="88"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="11">
        <location>
            <begin position="220"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE01400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="285" mass="31187" checksum="28F1529F716D80A5" modified="2018-12-05" version="1">MTKIFEKAPAKINLLLDVLRKRDDGFHEVEMIMTMVDLADRLEMEELPRDQIVLTSQAGFIPLDEKNLAFQAARLLKERYDVRRGVYIHLVKRIPVAAGLAGGSSDAAATLKGLNKLWGLGLSVSELELLGAELGSDVPFCVRGGTAIARGRGEKLESISPPPQCWVILAKPPINVSTADVYGKLRASQIAKHPSVPRMLDAIARQSFPDMCGELGNVLEDVTLDRYPEVRQIKECMIKLGADGVLMSGSGPTVFGLVSKEAKVARVYNGLRGFCKEVYVVRLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFX5</accession>
    <name>A0A398CFX5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">33 kDa chaperonin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 33 homolog</fullName>
            <shortName evidence="6">HSP33</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">hslO</name>
        <name evidence="7" type="ORF">D3H35_23460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HSP33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01335">
        <property type="protein sequence ID" value="RIE01335"/>
        <property type="gene ID" value="D3H35_23460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00498">
        <property type="entry name" value="Hsp33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.30.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00117">
        <property type="entry name" value="HslO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000397">
        <property type="entry name" value="Heat_shock_Hsp33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016154">
        <property type="entry name" value="Heat_shock_Hsp33_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016153">
        <property type="entry name" value="Heat_shock_Hsp33_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30111">
        <property type="entry name" value="PTHR30111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01430">
        <property type="entry name" value="HSP33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005261">
        <property type="entry name" value="Heat_shock_Hsp33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118352">
        <property type="entry name" value="SSF118352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64397">
        <property type="entry name" value="SSF64397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0862">Zinc</keyword>
    <feature type="disulfide bond" description="Redox-active" evidence="6">
        <location>
            <begin position="236"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="6">
        <location>
            <begin position="269"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="295" mass="31883" checksum="B464C8D24758BE09" modified="2018-12-05" version="1">MLDELVRGTAWNGGLRVFAARTTRLVSELQRRHGTFPTATAALGRAATIGAMMGVMMKGDNKLTIQVKGDGPLGQIVIDANAIGEVRGYVDHPHVHLPSNEHGKLDVAGAVGRSGFIYVIKDLGLREPYGGSVPIISGELGEDFTLYFADSEQTPSAVGVGVLVETDNSVVHAGGFIVQVLPGLSDEQLDRLEHALASMPHVTALLDQGESPESILKFLLGDDVTIHETIEPIFKCKCSRERVERTLFTLGPKELRSLIDEDGEAEVVCPFCNEAYHFTGEQLESLHNRASSELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGR9</accession>
    <name>A0A398CGR9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_22590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01670">
        <property type="protein sequence ID" value="RIE01670"/>
        <property type="gene ID" value="D3H35_22590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="310" mass="32579" checksum="3A9EA5C36EAF7EF1" modified="2018-12-05" version="1">MLLSTSLGDMRIHPLDVMRTLFGGGTDEHRLVIQKLRLPRIIAAFLVGAALAVAGAILQGIIRNPLASPDIIGITSGASLAAVTFISYLAGTVSIVWLPVAAMAGAAVTSIVIYMLAWRKGVTAIRLVLIGIGINFLLGSITKVILVKNPIQTSSQAYIWLTGTVYGTDWSIVWMIVPWVAVFIPLAFVFARNVNVLQLGDDIAAGAGSAVQRQRFALLMISVALAGAAVSVGGAISFIGLIAPHMTRKLIGPSFGGVLPVSALIGGLIVVLSDTVARTAFLPYDIPVGVFTAGVGAPFFIYLLYRNRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGS6</accession>
    <name>A0A398CGS6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Transcriptional regulator CtsR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_29950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the CtsR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00279">
        <property type="protein sequence ID" value="RIE00279"/>
        <property type="gene ID" value="D3H35_29950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008463">
        <property type="entry name" value="CtsR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041473">
        <property type="entry name" value="CtsR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041908">
        <property type="entry name" value="CtsR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040465">
        <property type="entry name" value="CtsR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041902">
        <property type="entry name" value="CtsR_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40028">
        <property type="entry name" value="PTHR40028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05848">
        <property type="entry name" value="CtsR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17727">
        <property type="entry name" value="CtsR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010607">
        <property type="entry name" value="Txn_repr_CtsR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CtsR" evidence="8">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="CtsR_C" evidence="9">
        <location>
            <begin position="80"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE00279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="153" mass="17222" checksum="09898A7FA77A8AA6" modified="2018-12-05" version="1">MRNISDLIEIYLKQILNDSSEGAVEIQRSDLADKFSCVPSQINYVISTRFTLEKGYYVESKRGGGGYIRIQQVDLPSLEAVQRHIQCTVGEQIDQTAAEGLIYQLEEARYMTSREAHLLRATISRDVLAIKLPLRDVIRANVLRAALIALLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGT8</accession>
    <name>A0A398CGT8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lsa family ABC-F type ribosomal protection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lsa</name>
        <name evidence="6" type="ORF">D3H35_22485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01172">
        <property type="protein sequence ID" value="RIE01172"/>
        <property type="gene ID" value="D3H35_22485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="310"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="342"/>
            <end position="349"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="492" mass="56602" checksum="16A5449850C7639D" modified="2018-12-05" version="1">MSLIKVANLTFAHEGSYDNIFENVSFQIDTDWKLGFTGRNGRGKTSFLNLLLGKYEYSGKIAANVHFEYFPFHVENKQSNTLDVINDICPDYLHWQLMRELSLLEVSEDVLDRPYDSLSNGEQTKVLLAALFLRENSFLLIDEPTNHLDLNARKLVSDYLQTKSGFILVSHDRSFLDNCVDHILSINKTDIEIQKGNFTNWWENKKRQDRFELAENEKLKKDIRRLSDASKRTSNWSDEVEKTKNGTRNSGSKVDKGYVGHKAAKMMKRSKAMEQRQQSAIDARSRLLRNIETSENLKISQLTYHKRQLAELENVSIYYGEKRVCQDVSFTIEQGERIALSGKNGSGKSSIIKLICGENLTYTGTFRRGSQLKISYVSQETSHLQGNLTDYARNNRIDESLFKAILRKLDFSRAQFEKDISAFSGGQKKKVLIAKSLSEQAHLLIWDEPLNFIDIISRMQIEELLLEYAPTILFVEHDSEFCNNMATKIIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH03</accession>
    <name>A0A398CH03_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_29560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00188">
        <property type="protein sequence ID" value="RIE00188"/>
        <property type="gene ID" value="D3H35_29560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="72"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="301" mass="34757" checksum="1A7C9D6CC416BD9B" modified="2018-12-05" version="1">MLIMLKRFMNHKSVVPYVLLFPFIFFFLVFRLWPIVWSFFISFTEYFGNGYKFIGLDNYRELISDRVFWIATKNTFYFVGVYNVIMISCALVLAVIVKSPKIRGRNIYRSVYFMPMAMMLPVVAIVFDMIFARNIGFISVIYSMFGEEFTARWFSDVDLAMWGIIIMRVWRGMGYYCAYFLAGLSGIPNEVYEAAQIDGAGVVRTFFRITLPLLKPMLMFVIIMSTILSFEIFDEPWILTQGGPANSTLTLQIYLYQTSFLDGNLSKGSAVAYIMTLFMMVFSIIYVRGLSEKNSSKSSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH57</accession>
    <name>A0A398CH57_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01302">
        <property type="protein sequence ID" value="RIE01302"/>
        <property type="gene ID" value="D3H35_23245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="67" mass="7659" checksum="234121357B418920" modified="2018-12-05" version="1">MSHHNEQDTPVSNNSLEPTYSKRQLLEAGRFTPLQKDVLSAVLTNYELYSVDKAERMISDFEQGTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH75</accession>
    <name>A0A398CH75_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_29020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00449">
        <property type="protein sequence ID" value="RIE00449"/>
        <property type="gene ID" value="D3H35_29020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017448640" evidence="2">
        <location>
            <begin position="40"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="76"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="335" mass="36573" checksum="388E2CEFDF6E7679" modified="2018-12-05" version="1">MSRMNNRLAWTGSALLLTLSLAACGSSNSGSAKPSDSSAKPSASEAAAQQTNEATPSPSSRVVNDIFGEVRLPENPQRIVAPYVEDALVTLGVKPSMQWSLGELVQDYLQPYLQDVPKLDFTGGANLEVLLASSPDLILLYNKTMAENGAYEKFAKIAPTYAFEDATVDWKGTLRTLGDFLHKSDEAEKAIREYETKSSAAKEKLKPIVDGKTFAVIRVKPKEFLLMDGTYYSGPVLYGDLGLTPHKLVRELSWELNKPLSLEMLPELDADYIFLLVQGEAAKAKAKELTDSPIWQGLPAVKQNHVFNADISYWMSSGAIANTKKIDDVLKAVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHB7</accession>
    <name>A0A398CHB7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_18100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02596">
        <property type="protein sequence ID" value="RIE02596"/>
        <property type="gene ID" value="D3H35_18100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="610" mass="64187" checksum="3115BA047D7A4874" modified="2018-12-05" version="1">MIEQILKPFIKPIKRMIIMPLKRAKQLPKLILRWLISWMRNVMGSGLRSLDNYWKLGTFYIAKKLIVIILLISLAIVFFVFIKPPKFVDKWFSRTPKIEASAAAAQGFSGQAKITNEAGELVYAGPLKDGLYSGTGKLFGPGGQLLYAGDFDKGLKTGKGEQYDSEGRLLYRGEFANDQYAGAGSLFAADGSLVYEGAFAGGKYEGEGTLYASKDVVRYTGAFVAGVFQGEGKLFGDDGKPVYEGAFNGGVYEGAGKLLRNDGTVQIEGNFLGGVASGEGTEYYPSGAAKYKGAFALGRYHGAGTLTNDQGVAIYTGAFVNGLREGDGQAFLPDGTPLYAGKFKADRYEGIGTLLDADGGTVYKGYFRGGKMAVQAFLGLALPKLQEVLGPADPPKEEEASTEEEIPSGEEEPAASPDPLPSPEPSATPSPSSEPSPSASSSPGASPATEAAPSASEPASSAEPSASPSGAASAAANKKATVTILSAATAEPSIVSPTAAATSTSEPSLSGETVAVPMELVYSASQFSFKLIADEDNPEAYFVSEIRSWNRAVLNEVAAQIEASGSKGVKTPLAAGKYEIAYEWNGTLVILTYNKETPVRLSISLMNTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHS0</accession>
    <name>A0A398CHS0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CopG family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01552">
        <property type="protein sequence ID" value="RIE01552"/>
        <property type="gene ID" value="D3H35_24695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="67" mass="7717" checksum="48DF19C5CA29E4AE" modified="2018-12-05" version="1">MDNDDFIVTPKEKSVTITIRVDKAIADKLDSLALQSERSRNELINMALDYALKNVKFMRSTSENKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI44</accession>
    <name>A0A398CI44_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02110">
        <property type="protein sequence ID" value="RIE02110"/>
        <property type="gene ID" value="D3H35_15230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="227" mass="27023" checksum="F9AC7EC1F22868C3" modified="2018-12-05" version="1">MTFEEAHKEFIGRHLNLRKGERRGRLERGHRHGERLFCEKIWWELKGGFDDLHPEYEVTDWCGKSYFADFAYKVPGWKVTLLWEIKGFNSHVKEMDRNRFCGECRRELYLEALGFHVISIAYDDVESNPELIIAFMRMLLSRYETRKEPVLRSFFEENEVIRLAAGLARPIRPKDVEEHFGINHRTAVRLLKSLCTKGWLVPLMRGTGNRKVRYELTRAGMESMWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIP6</accession>
    <name>A0A398CIP6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_16100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02255">
        <property type="protein sequence ID" value="RIE02255"/>
        <property type="gene ID" value="D3H35_16100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="300" mass="33997" checksum="F374C491D77DB028" modified="2018-12-05" version="1">MNSLNVDRIVKDYGDKRAVNGLSFEVAQGEIYGLLGANGAGKTTTMRMVLGLILPDGGAIRYFGKAYSQEQLSMLGYLPEERGMYPKIKVSDQIIYLAQLRGMSRKDADANLKRWLDKFEVPEYYNKKVEELSKGNQQKIQFIAAVIHNPKILILDEAFSGLDPVNVELLKTTVKELRDNGTSIVFSTHRMEHVEELCRNITIMHKSNPVLQGPIKEIKKRFPQERVMLAAEKPISGLENVPGVREVIRHEHGYELKIQSESAAQDILKHALAQGPIRRFELMEPTLNEIFIKTVGERHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ01</accession>
    <name>A0A398CJ01_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_22585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01189">
        <property type="protein sequence ID" value="RIE01189"/>
        <property type="gene ID" value="D3H35_22585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="336" mass="34804" checksum="F869AC16BF6DB6A0" modified="2018-12-05" version="1">MGRLFAGSLAKGSGLALGFIVMVALVYASMIYGLTPIGWSDVYHSFTNYDTSSNEQVIVQTARMPRAFTAAAIGASLAVAGSLIQGLTRNPLADPGILGINFGSSFALVFTATVLSVSSLPVLTGVSFAGAAVAAAAVYLLGSLGRDGLTPLKIILAGAALSALFTSFTQGMLVLDEQGLSEVMFWLTGSVANRSFDMLKAVLPLMVAGWIASLWIARHMNVLTMGEDTAQGLGQRTLFVKLAAGLIIVALAGGSVAVAGPVGFIGLIVPTIARQFSGNDYRWIIPYSAVLGAILVLAADIAARFVIRPEELPVGIMTAIIGIPVFIAIARKGIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ66</accession>
    <name>A0A398CJ66_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000045">
        <property type="protein sequence ID" value="RIE00868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00868">
        <property type="protein sequence ID" value="RIE00868"/>
        <property type="gene ID" value="D3H35_25990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="72" mass="7953" checksum="017B96C227D87D82" modified="2018-12-05" version="1">MNALREKAGWPLEAEAQQRNGQLEELKRLVSAIPDSVPPAVRTEAASALERLESEWAKLVPDKLLAKGCLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJP1</accession>
    <name>A0A398CJP1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1 2">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pth</name>
        <name evidence="4" type="ORF">D3H35_23765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PTH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1 2"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01389">
        <property type="protein sequence ID" value="RIE01389"/>
        <property type="gene ID" value="D3H35_23765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="190" mass="21215" checksum="0A3D69DB79B81C5E" modified="2018-12-05" version="1">MRWIVGLGNPGAAYEKTRHNAGWFVIDELARRWGVQVGQNKCKGLIGEARVQGVKVGLLKPMTYMNLSGESLRAYMDFFKVKLEDAIVVYDDLDTEVGRIRLRYQGSAGGHNGIKSIIQHTGTQTFNRVRLGVSRPKTGMVISDYVLSTFAKAEQQDVSRMVEEACDAIEFALQHPFEQAMAKFNGRTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJS1</accession>
    <name>A0A398CJS1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02560">
        <property type="protein sequence ID" value="RIE02560"/>
        <property type="gene ID" value="D3H35_17895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="585" mass="64094" checksum="2F2587F1C16A986F" modified="2018-12-05" version="1">MAFSSTARSIKTRASRYKYDGFNQLVKVSSGSGGSTYEYNGDGLRVKKTTASGTTAYLYEYDKVVLETDGAGKQTARNTYGINLITRTAGTDKFFYLYNGHADVTALINTVGTIVGTYEYDAFGNITNKTGTSNNSIRYAGYQYDEENKLYYLNARYYDPKIARFLSEDTYRGQADDPLSLNLYSYVHNEPMMYVDPTGNTDVSLREIAGATGSTIVYDAKTKTATVTLVSGYSVTFDPKQKGSGVTLVNGRMIVDNEVFDKMMTGSKKTSSGTIYAYVDSYVAPSVKDKKGNEIEAAKVAVVTLVGKQTNSYVKNDFGFAVPEMKTLRNSTVIYNKDTNKVLDTTSVFSLPSFLSPQALGGENSNSLAYSALVGYAFKDGEMNKGERKQLDFSKDGAALLELSIRLNKQGMSLAQASFLYQQQYGNFDLVAAYAGIRSIKVGGSVSAPVKVVNRSSFTSNRRSSNTSQGAGNSAKLSSSTNPNDYLNTALKRQGLDKAPSNFKEKWSQDGYDYEVRIHPADPKYGKQGDIYRVARREQGTDANGQGKGWEYMDSNGNWHSTSSLKPQNPSYNAQAAADTHIQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJU6</accession>
    <name>A0A398CJU6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alkaline phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_10930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03586">
        <property type="protein sequence ID" value="RIE03586"/>
        <property type="gene ID" value="D3H35_10930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="PTHR11596"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017347706" evidence="2">
        <location>
            <begin position="33"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="3">
        <location>
            <begin position="608"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="684" mass="73029" checksum="70AB60EEAD9D4DF9" modified="2018-12-05" version="1">MNAVKVTLGVLLASGAIVSATGLPTYPQTANAAEQAAATAVAKPSVYIAPIDRAKFLAGSKFDFRVELNDLTGDPGNVAITVNGKEASAFFGKAFEKTSTAKSREFTIRDVTIGKAGTYTVSVKAGSLSKSVKYEAVTADVAGKKAKNVILFIGDGMGISSVTMARIMSKGLTEGKYNDLLQMDKFDQRAIVTTSGMDSLVTDSANSASAYNTGHKSAVNGLGIYPDNTESSLDDPKVETLAEMLKRTRGMSVGVVTTSEIEDATPAAVVSHTRRRSDKPEIAEMLLKLQPEVVLGGGSAYFLPKSVAGSKRKDEKDLIADFEKSGYTFAENATQLKAAKSPSKLLGLFHTGDMNVYYDRSTNNKEALKSFTDQPNLWDMTQKAIDVLSKNENGFFLMVEGASVDKQLHAMDWERSAYDEIELDKAIGVARKFAEQNGDTLIVATADHNHSASIAGTYWEGDGKSGREAIRTYEAAKFPTYTDANKDGFPDSPNPDRKLAVVFGATPDYYEDYKFNAIPQAPAVNSDGKYVANPATLANPDDPNKDRFLHTGTLDPKVDSTEVHTADDVPLMAYGPGASYFKGTLDNTEVFFGIVNSLGLSLTGAKPDGKTWVSLTEFLNVIGGSAKYDSAKNTTTVKANGSTLVLNLAKRTATKNGKAVALEFKISQGKTVVTSNSLLAALAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK50</accession>
    <name>A0A398CK50_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1573 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_30015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00267">
        <property type="protein sequence ID" value="RIE00267"/>
        <property type="gene ID" value="D3H35_30015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="131" mass="14681" checksum="2F9F869EC73880E5" modified="2018-12-05" version="1">MSAPSLQQFQEQVSELLLRHRSLLDVVTKYTQSNGSVNRAVAKSITECGCIELNARPQGFNEEMELDQAKRQSKSHMNGHLCEACGEVVRSEMGKNLFYLSALCNILDIRLEEVVAKEADKCSTLGWFNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK77</accession>
    <name>A0A398CK77_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02552">
        <property type="protein sequence ID" value="RIE02552"/>
        <property type="gene ID" value="D3H35_17840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="133" mass="14411" checksum="76FC56551850D473" modified="2018-12-05" version="1">MRVWGNAAQGTETFYRTMSKADYETFLKTGKVPATSETFISPTRSFSEGYNGVIVEFKVKAGTTNSLANIGVRDSSAIVKDAYGNMPTVGKGWTSNNAYFKGEDGQINIGLGKGKALDTFNDNIVEYKVVGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKR5</accession>
    <name>A0A398CKR5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_28255</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000055">
        <property type="protein sequence ID" value="RIE00477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00477">
        <property type="protein sequence ID" value="RIE00477"/>
        <property type="gene ID" value="D3H35_28255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="66"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="184" mass="20725" checksum="05F513C7DFABFB9F" modified="2018-12-05" version="1">MRLFRRERQSWRSGTEEAFVGNAAQYMIPSFFVRVEQMPLTPNGKLDRKALPSPEGTLERGTVYEAPRNALEETLANIWQGVLGVSAIGITDNFFELGGHSLKATTLVTRIHKELNVQVPLREVFQSPTIKELAQAIRGMEAHAYASIEPAPLREYYPVSSAQKRMYILSQLQGAEQSYNMPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKS8</accession>
    <name>A0A398CKS8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="11">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">rlmN</name>
        <name evidence="13" type="ORF">D3H35_13525</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="11"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01809">
        <property type="protein sequence ID" value="RIE01809"/>
        <property type="gene ID" value="D3H35_13525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="98"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="164"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="11">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="(transient)" evidence="11">
        <location>
            <begin position="105"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE01809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="362" mass="40481" checksum="587A5D9ECD238B0D" modified="2018-12-05" version="1">MNRPSLYGLTLDQLTAWLGERGHKKSRAAQVWDWLYRKRVTDFAEMTDVHADCVKVLAESFDITTLREHTKQQSADGTVKLLLQLQDGNLIETVLMRHKFGLSVCVTTQVGCNIGCSFCASGLIKKSRDLSSGEIVGQLMKVQQHLDQAGQGEKVSHIVVMGIGEPFDNFENLVDFLTVVKDHKGLAIGARHITVSTSGLADKIYEFTDRSLQVNLAISLHAPNDELRTRIMKINRAIPIEKLMKAVDYYLEKTNRRITLEYILLKDVNDRKEHALELAELIGDKRKPLANVNLIPYNPVDEHSQYQRSAQESILAFYDTLKKQGVSVSVRLEHGADIDAACGQLRSKQLKEEAAPEGATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKT5</accession>
    <name>A0A398CKT5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02772">
        <property type="protein sequence ID" value="RIE02772"/>
        <property type="gene ID" value="D3H35_19230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="154" mass="18156" checksum="32A17E0E5EDA6231" modified="2018-12-05" version="1">MKPEILPLNELEQLEESVKIQTLQQYRASHTIKDLSQAWGLSNPIQYYMWLKKQNIYEQLVRKADKFEPSKEWKRLQETEKREFDRARTRGLSADQFRYTLDTDSSGAELAQVFRRLADFLQNESGNFRCRIELKAISQQAGLPKEWKDEEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKV6</accession>
    <name>A0A398CKV6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM/CxCxxxxC motif protein YfkAB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yfkAB</name>
        <name evidence="6" type="ORF">D3H35_08250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03946">
        <property type="protein sequence ID" value="RIE03946"/>
        <property type="gene ID" value="D3H35_08250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031004">
        <property type="entry name" value="rSAM_YfkAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014866">
        <property type="entry name" value="YfkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42836:SF2">
        <property type="entry name" value="PTHR42836:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08756">
        <property type="entry name" value="YfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01097">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04478">
        <property type="entry name" value="rSAM_YfkAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="39"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="385" mass="43919" checksum="32EBB349FBEE4CFC" modified="2018-12-05" version="1">MHAIPLPTVARAPFAAPDGWKPLSPTNDPWDPIHSLQRFGRHALTSVELTVTHLCNMRCEHCAVGDSLTMTEAPFMPLDLILRRLDEVEHLETISLTGGEPTFRLETVKEVIVPLLKYARSRGIRSQLNSNITLDYDRYELIAPFLDVMHISFNYTEAEDFHRVGFARSGRSVSRNASSRLYERMVDNARKLSDGGLFVSAESMINFHTYNRITDIHRLIVEMGCQRHEVHPMYPSSFAANLPRVTREQMREAIEELLEHRNKDVWMLLGTLPFFACSADSDERSLVRRLRSEPNLTVRNDPDGRNRVNVNMFSGDVYVTDFAAVPPFGNVKEERLDDVFAKWQAHPMQKAVNCHCPEAACCGPNLLVSDMYYKDVDFLQRKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKV8</accession>
    <name>A0A398CKV8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-D-alanine carboxypeptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_19400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02802">
        <property type="protein sequence ID" value="RIE02802"/>
        <property type="gene ID" value="D3H35_19400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003709">
        <property type="entry name" value="Pept_M15B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02557">
        <property type="entry name" value="VanY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VanY" evidence="2">
        <location>
            <begin position="163"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="318" mass="33981" checksum="449C50E5459379C2" modified="2018-12-05" version="1">MGTVHKCSGRQQPPYSRIPSSTIGPGETPSDTPTDAPVDDPSEEPNESPASYPSDDPAGNPSASPSANPSDEQPSETPSKEPKPQTDPQGNKGENSSNAIPAWAANSLPSLTVERKNGLAVISNPSSLYVLVNKKRNLSSSYAPKDLVQPDIPFSFDGDSPKKKLRRQAAEALEKLFAGAGKAGIELKGVSGYRSYATQKAIFTANADKKGEAEANRTSAYPGQSEHQTGLAIDVSSAAVGYALEESFGKTKEGKWLAAHASEYGFIIRYPKGKEKITGYKYEPWHIRYIGKEAAKDITASGQTLEQYFDALEASVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL05</accession>
    <name>A0A398CL05_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00577">
        <property type="protein sequence ID" value="RIE00577"/>
        <property type="gene ID" value="D3H35_27985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007395">
        <property type="entry name" value="Zn_peptidase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36434">
        <property type="entry name" value="PTHR36434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04298">
        <property type="entry name" value="Zn_peptidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="228" mass="25378" checksum="86F290C338869268" modified="2018-12-05" version="1">MFFHPMDFLIIIAFLLSLWAQFRVKGTFNRFADVRAMSGLTGYEAARRMLDRNGLHDVPIEPVPGRLSDHYDPIHRVVRLSEPVYYESSISAISVACHEVGHAIQHQNHYPMLVLRHRIFPLVNIASGIAPFLLIAGFLFQATGLIGLGIVFFSIAVAFQLITLPVEFNASSRARDLMVAEGFITGEEERGVAKVLNAAALTYVAAALISLLELIKYIMIFTSSSRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL20</accession>
    <name>A0A398CL20_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative competence-damage inducible protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cinA</name>
        <name evidence="3" type="ORF">D3H35_11755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CinA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03353">
        <property type="protein sequence ID" value="RIE03353"/>
        <property type="gene ID" value="D3H35_11755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00226_B">
        <property type="entry name" value="CinA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041424">
        <property type="entry name" value="CinA_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008135">
        <property type="entry name" value="Competence-induced_CinA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18146">
        <property type="entry name" value="CinA_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006728">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00200">
        <property type="entry name" value="cinA_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="2">
        <location>
            <begin position="4"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="417" mass="44226" checksum="C07A134865F5B473" modified="2018-12-05" version="1">MRAEIVAVGTELLLGQIVNTNAQFLSRALAELGIDVYYQTVVGDNKDRIKQAIEIARDRADLIVFTGGLGPTLDDLTRDALAEYLGRGIVLHQPTMDKIEEMFSSRGVAFVESNRRQALLVDGASPLRNDTGLAVGNALAVEGTHYLLLPGPPREMKPMFTNDGSAWLRERLGASFALHSVMLKFAGIGESALEDLLIDLIREQADPTIAPYAKEGEVAVRVSTKASDPEDAARKLEGTLTEIRRRTADYLYAEDDVGIEAAVLRLLTGLRGTLSLAESCTGGMIAGMLTTVPGSADAFVGGVVSYSNGVKRKQLGVPEGLLEGEGAPGAISAETAAAMAEGVLAAMDTVYAVSVTGVAGPGSSEGKPVGLVYIGVAERGADTRVEKLQLSGDREGIRLRASKRALYLLWQVLTGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL32</accession>
    <name>A0A398CL32_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyl-accepting transducer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_20010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02902">
        <property type="protein sequence ID" value="RIE02902"/>
        <property type="gene ID" value="D3H35_20010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="2">
        <location>
            <begin position="171"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="398" mass="44317" checksum="B0506778B75C87A9" modified="2018-12-05" version="1">MSLVLLERPTPPMISTPPASLTPPPLEALIERELFQPVVVADWLRGCPVVSGDQACSELVGLFRQKSELECVVVCDEGRRPVGLIMKHRFFRMLGSLYGMSLYGERPISVLMDAKPFMTDTSIAPQELIDRALSREESTFYDVVVLTKQQKFAGILTVSDLLHMSRLLQRETSDKQIRTVRGTETMIGEIRGAVEKVTVTTKDTQECSERIFETTEKGRNDLSDMHNLFKRWSDIAIRQDRAIEELTQRTASADSIIRLIGELAVQCNLLAVNATIEAARAGEHGRGFGVVADEVRALADQTKQSTDQISKLLRSMTEAVKEAESLVKEGKRSADHGVQQVVKTEDTFNQLWKSSTRNMEAADRLNGVSRDANDLLNKIGVEFEKLVAQMNGNPPNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLI9</accession>
    <name>A0A398CLI9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03102">
        <property type="protein sequence ID" value="RIE03102"/>
        <property type="gene ID" value="D3H35_21230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="103" mass="12063" checksum="F6152A71DE1C29A4" modified="2018-12-05" version="1">MDLDIPIEIPSSKLAGSYDRVIKLNTPDGYCYVIGIEDLILDRLNAAEFWQDTRSLEWARYLMSSQFEGLDFNYLREKANEDNPNLSRRLEDTIKWVKENTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLJ4</accession>
    <name>A0A398CLJ4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ParB/RepB/Spo0J family partition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_10810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03533">
        <property type="protein sequence ID" value="RIE03533"/>
        <property type="gene ID" value="D3H35_10810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="4">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="240"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="418" mass="45754" checksum="45196E1FF668B4DF" modified="2018-12-05" version="1">MDIIEILTDLIDEDTDQPRYQFNEESLQELMNSIEELGLLSPIKVRTTGDGRYKIIYGNRRYKACKTLGRRTIPCIVSTVTDEVEIYLEQIAENLTREGFSPIEEAEAFDKLLHNPAFNSSTKFLAGKLGKPEAYIKNKCELLRFGNAVKKLIVHGTEIRKDALTEDQLLPLKDLAMEHRDSLALIVARDAMPVTDVKRIAKLFKDPGISEGTKSKLLYKTGYELLETWSVYDHNRKEREKAAKEKEAAKKRAAEQRDDDDGTDEDEENAGTGGKREASAAGTAGLSATAGDARMSGAVDGARANGMAAVADGLRTTGTAAANGAASAATAADGAKTTAAGAANAPLEPAIVTTLRQLHASLPDHRILLEVTKNSIGELSFQQEEPFRQSIDRAIDSLEKQLAEWKNVRELVKSTLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLJ9</accession>
    <name>A0A398CLJ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemotaxis protein CheW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03305">
        <property type="protein sequence ID" value="RIE03305"/>
        <property type="gene ID" value="D3H35_11490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="153" mass="16852" checksum="851AE3185AA14C34" modified="2018-12-05" version="1">MAEEMKVIVFTLAHEEYGIEVDKVRTIERMIPITRVPKTPAFVKGVINLRGIVIPVIDLRGRFGLEETEPSESSRIIIVAANDLEVGFIVDSANDVLDVASDAIENPPEVVGGVKAKYLRGVAKIGDSRLLILLNLSEVLNRSEIIQLEKFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLT7</accession>
    <name>A0A398CLT7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03405">
        <property type="protein sequence ID" value="RIE03405"/>
        <property type="gene ID" value="D3H35_12090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="91" mass="10832" checksum="1AF3510856151CF9" modified="2018-12-05" version="1">MGAIRQWAKSDGRVQGIIVEVEAEDNEENRSRIRFWERCGFTLTDYVHRYVWVPETYRAMYAKLDSDSSMPEDGKRLFGHITSYHNRAFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLX3</accession>
    <name>A0A398CLX3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04346">
        <property type="protein sequence ID" value="RIE04346"/>
        <property type="gene ID" value="D3H35_07030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="18"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="101" mass="11211" checksum="7B331FC00BB301AD" modified="2018-12-05" version="1">MSDYATITSEELKARLDAGENIRLIDVREAEEVAHGIIPGAEHIPLGQVPQRLDDIPREEEVIFICRSGYRSGQACEYLTMLGFKQPVNLTGGMLAWAQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM06</accession>
    <name>A0A398CM06_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2087 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_16070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02249">
        <property type="protein sequence ID" value="RIE02249"/>
        <property type="gene ID" value="D3H35_16070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018656">
        <property type="entry name" value="DUF2087"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09860">
        <property type="entry name" value="DUF2087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DUF2087" evidence="3">
        <location>
            <begin position="182"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="251" mass="29482" checksum="4EC71FC43B158E7F" modified="2018-12-05" version="1">MDLTERFWNASLEELKWGYAEEKEAYVCLVCGHSAEKGVVYPGDGVWYEAAKYIRRHVEGAHGSMFDYLVSLDKKLTGLTEHQAQLLRLFHQGRSDAEVQKELGIGSASTIRNHRFALKEKERQAKLFLAMMELLKERDRHAPAFMDVHRTARMVDDRYNVTEREREAAIAKYFLEGPEGMLKTFKLPEKQKLIVLRQIADRFERGRIYTEKESNEVLKTAYDDYVILRRYLIEYGFLDRKPDGSEYWLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM19</accession>
    <name>A0A398CM19_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SPFH/Band 7/PHB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00907">
        <property type="protein sequence ID" value="RIE00907"/>
        <property type="gene ID" value="D3H35_25380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="1">
        <location>
            <begin position="19"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="312" mass="34374" checksum="648D5EFCB962B004" modified="2018-12-05" version="1">MGLFIALVILAIIVVAIALSVKIVPQQRVGVVERLGKFNRLLTPGINILVPIIDHVRVNHDLRIQQANVPPQTVITKDNVQVQIDTIIFYQIVSPEQATYGISDYVFGVRNITTATLRQIIGKLELDETLSGREKISTEIRHALDEATEKWGVRIERVEVLDIKPPADIQDSMDKQMKAERSKRAIVLEAEAAKQDMILRAEGDKQSKILKAEGDKEARIREAEGFRQAQELEALGQAKAIQAVAEAEKVRIEMLRAAGLDENVLAYKSFEALGEIAKGPANKVFIPSNAIETLGAVGAIGEMFKAVKKTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM21</accession>
    <name>A0A398CM21_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_27355</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00691">
        <property type="protein sequence ID" value="RIE00691"/>
        <property type="gene ID" value="D3H35_27355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="332"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="494"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE00691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="606" mass="69885" checksum="F73347C88E30C24F" modified="2018-12-05" version="1">MRTGLYARGFFRHNLFVRILAVFSLIAIVTIVTLSYFAYLFITDSMLDNERDKQKSAMDRVSRYVEKKNESIQMKVQSIYRDQQLSENLTFLLKTSYQEYVEHRLDRFNEGSGMYKGLDYLKSMIEDDPDIENILLFSTEKQFLYVNSQRNLSKLFETNEAHSYVPDAMALQSGIVSVPNNWVRKTIDQWNEKLYSMRSNINDVGTLKTVGQLLVFFRSEAIESVLSESGSRIKGSILVLSPEGYVIFDSSDRYYGRVYPFKDKLNSIKGADMLDESSYISTLSANNLGYSVVGILPKEEIAASYQPAKRLIILISGACILTAIVVPSLFVLNFAKRTNRLIRTMRRVETGDMTVRIHDTKEDEIGQISRGFNQMLAELTRHIDRVYKAEIKQKHTELTALQARINPHFLYNTLEVIRMRAISQGVTDVSEMIYSLAVLFKSFVHQQTVVSLREEMDNCARYLELFRIRYKDKFSYRIDYDPELSDWKMIKMSLQPIVENYIVHGMRTDGQDNEIAIRAVGEENIIRVTIQDNGIGVTSEKLERIRRNLERPENASEESSLGLYSVNERLKLMYGKEYGVEIWSEPAVGTTVILWFPYSQGSDSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM55</accession>
    <name>A0A398CM55_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Low temperature requirement protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00947">
        <property type="protein sequence ID" value="RIE00947"/>
        <property type="gene ID" value="D3H35_25640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="PTHR36840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="401" mass="44145" checksum="815F767C6B614E4B" modified="2018-12-05" version="1">MEKRTSEAALFRSRGNTDSGKVSFIELFFDLIFVFAVTQLSHALLENFTLKGAVQAALITMAIWWVWIFTAWVINWLNPDTKPVRILLISLMLLGLMMSSSIPDAFEHTGLYFGIAYALFQIGRTGFTVWVLRQGPDELRLNFIRILGWLILSGMFWISGGIVHDSWRLALWLAALLIEYISPSLGFWMPRIGRSPTNVWNVEGSHLAERCGLFIIIALGESILVTGATFAKLEWSPTTLGAFAVSFAGTVAMWWIYFEMTAKIGHHYIAHSSDPGRIARSAYTYTHLLLVAGIIVSAVADELLLVHPSGHIDAKTAAVILGGPAIYLLGNMLFMRIVARTVPMSYLMGLVALVLLAPFASELSPLILSAAAAAVLVIVSIWGSAFSERLCKLVPSPESRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM68</accession>
    <name>A0A398CM68_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxypeptidase regulatory-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04446">
        <property type="protein sequence ID" value="RIE04446"/>
        <property type="gene ID" value="D3H35_07630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="78" mass="8546" checksum="7F0FDAC86F508A9C" modified="2018-12-05" version="1">MQVLPDLMLEDAPSDLLRGTVTDEDGNPVPNLTLMVLDENAGEETLNKVNTLVYPDEKVVILCPISLPGIDTTFLYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM98</accession>
    <name>A0A398CM98_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat-inducible transcription repressor HrcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">hrcA</name>
        <name evidence="8" type="ORF">D3H35_06020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HrcA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04476">
        <property type="protein sequence ID" value="RIE04476"/>
        <property type="gene ID" value="D3H35_06020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005104">
        <property type="entry name" value="WHTH_HrcA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023120">
        <property type="entry name" value="WHTH_transcript_rep_HrcA_IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03444">
        <property type="entry name" value="HrcA_DNA-bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005485">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00331">
        <property type="entry name" value="hrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0678">Repressor</keyword>
    <keyword evidence="3 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HrcA_DNA-bdg" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="HrcA" evidence="6">
        <location>
            <begin position="106"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="341" mass="37927" checksum="11EA59879E9AA37E" modified="2018-12-05" version="1">MLSERQRMILSAIVDDYIRSAEPVGSRSISKRTDVSFSPATIRNEMADLEELGLLEQPHTSAGRIPSIKGYRYYVDHLVTLGGVGEQDVRKIRAFFAEKMNHWEGVIGQAATILSQLTNYTSIVLGPETFSTSLKHFELVPLNERSAVAIIVANTGHVEHRTMTIPDGIEMEDLQRIVRILNEKLAGVPFIRVKTVLHSEIANELGRYVDRCEQVLAVLEQTLSEQQDPKMYMSGASNMLGQPEFKDADKVKPILDALEATPQLLQLFQSAQEGIQVRIGTENALQAINSCSLITASYSIDGKSLGTIGILGPTRMEYGKVISLLDYLSKDIEAIMTKWYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMT3</accession>
    <name>A0A398CMT3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="14">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 20" type="primary">secA</name>
        <name evidence="20" type="ORF">D3H35_15170</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="14">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the SecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="14"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02098">
        <property type="protein sequence ID" value="RIE02098"/>
        <property type="gene ID" value="D3H35_15170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-1278">Translocase</keyword>
    <keyword evidence="12 14 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14 15" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="19">
        <location>
            <begin position="2"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="88"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="415"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="790"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="792"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="104"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RIE02098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="836" mass="95366" checksum="48A21C308DB083D7" modified="2018-12-05" version="1">MLGLVKKIFGDANEREVKRLSKTVEQINALEPQISPLSDEQLRAKTEEFRARLEKGEDLDDLLPEAFAVVREASKRVLGKRHYDVQLLGAMVLHSGKIAEMKTGEGKTLVGTLSVYLNALASKGVHVVTVNDYLALRDSQEMGRIYEFLGMTVGCNMHGLSHEEKQQAYACDITYGTNNEYGFDYLRDNMVLYKEQMVQRPLYYAIIDEVDSILVDEARTPLIISGQAQKSTELYFAADRFVSKLRDVEDFTIDVKMRSITLTEQGVNKTEKAFNIDNLYSHEHVLLNHHVNQALRARYIMKRDVDYVVQDEEVIIVDEFTGRLMAGRRYSDGLHQAIEAKEELKVQNESMTLATITFQNYFRMYRKLAGMTGTAKTEEEEFKRIYGLEVVQVPTNRPNIRQDIPDIVYKSENGKYKAVVEEIVERHKTGQPVLVGTVSIENSERISDMLKKKGIQHKVLNAKYHAEEAEIISRAGQHNAVTIATNMAGRGTDILLGESVPGVGGLHIIGTERHESRRIDNQLRGRAGRQGDPGSSQFYLSMEDELMRRFGADNIMGMMERLGFDENSPIESRLITRAIESAQKRVEGSNFDARRVVLQYDDVINLQREKIYGDRRQILFSDNIREVVVGMIKSVVTRAVESHCSSEDVPEDWDLDGLLTYAHANFLPEDRLTKDDLWGKEKEDMIEMLMERIGQLYDEREESIGSDTMREFEKVVVLRAVDSKWMDHIDAMDQLRQGIHLRAYGGNDPLREYQFEGHNMFLGMIERIEEEITLYIMKAQVESNLKREAVAEGQAVDTKAEEGKRPAKREEQRIGRNDPCPCGSGKKYKMCHGSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMY0</accession>
    <name>A0A398CMY0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">tatA</name>
        <name evidence="8" type="ORF">D3H35_15465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms a complex with TatC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02148">
        <property type="protein sequence ID" value="RIE02148"/>
        <property type="gene ID" value="D3H35_15465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="67" mass="7367" checksum="9BBF3E040F2EB9F1" modified="2018-12-05" version="1">MFHNIGVSGLLIILIIALIVFGPAKLPQLGKAFGETLREFRNSTRGIADDEKLDPIELSKEETGKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN36</accession>
    <name>A0A398CN36_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_10140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKC lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03650">
        <property type="protein sequence ID" value="RIE03650"/>
        <property type="gene ID" value="D3H35_10140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008844">
        <property type="entry name" value="Spore_GerAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038501">
        <property type="entry name" value="Spore_GerAC_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35789">
        <property type="entry name" value="PTHR35789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05504">
        <property type="entry name" value="Spore_GerAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="198" mass="22216" checksum="0241B1BA203BADF3" modified="2018-12-05" version="1">MRADRSFLLQNIVSAEGEVKFAGAAVMDGKSKKLIGFLDEEELSGIIWMMGKARGGLIKSYDEQTKRLITYEVVSSNATISSKVSGGRVSFRVKIESEGRLIENDVPGGVPSRKAFLKRVDETFEKQLKMTLERALDKMQEQYGVDAAGFGDRVRIQHPRVWEKVKREWDETFRDSPVTFDVKLSVTDYGASSGLVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN46</accession>
    <name>A0A398CN46_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_18590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. EmrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02669">
        <property type="protein sequence ID" value="RIE02669"/>
        <property type="gene ID" value="D3H35_18590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="9"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE02669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="469" mass="49268" checksum="D4B926C17D9A980F" modified="2018-12-05" version="1">MFTVSRVRLLVVTCTALFMAMLDNLVLGVALPSIQKSFDAGISDLEWFMNAYTLAFSVLLIPFSVFGERWGRKRMFLSGVVLFTLGSALSGLSDSSIQLILSRALQGVGGAAIVPLSLTLVNSAFPPEKRAAALGIWSGISGLGLSVGPLVGGLIVEGAPWQLIFWVNVPVGVLAFFLGQKWLHESQGNKRPLDPLGILLLGVGLFGLVFGLERGNAEGWDSFIVIGSLAGGVLLLLCFYLWERGRKQPFVRFSFFRNGKYSALIFAGFWMNAGVFGAIFLLTLFLQQAQGYSALEAGIREMAWTGCTMIAAPLAGLAVNRFGTKSVLSVGLLLQTLALLGFGLLIASIGVDFPFGYQAPLMMMAGAGMGLSFTPLSHGILSSVPETSAGEASGMSNATRELGGVFGIAIGGLVFQTGSAIRTPAEFGDHVVPALLTGAIMIGIGLVSVLAFTRASSGKIPQAAVEGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN57</accession>
    <name>A0A398CN57_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_08810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04043">
        <property type="protein sequence ID" value="RIE04043"/>
        <property type="gene ID" value="D3H35_08810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX_ECD" evidence="9">
        <location>
            <begin position="68"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="290" mass="31261" checksum="289279E4DA4DC1EB" modified="2018-12-05" version="1">MRSPISYYIRDACAGLRRNAGAAAAACALVFAATAIFGTLLIVRSGTGALMNYLESQITIKLYVEPSRDARELSDILVRQPYVKSASVETKEQLLERFGLFFQDKRHLLESLQGSDIPDAVTLELTDPSKTALVAGELQTLDGIATVIYPQKYAAALYKGADALAKYGFALFVFFAAIAFINVLLSIHLSLQQRKREIRVKLLLGARPLLVRGQFLFEGSVVALAGSLLAALAVYTAHVRVLIPLDRRLSGVIGLTTPELCAILAAMTLGGTLIGLTAAYLSTRKLISNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN85</accession>
    <name>A0A398CN85_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein D3H35_21615</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_21615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01041">
        <property type="protein sequence ID" value="RIE01041"/>
        <property type="gene ID" value="D3H35_21615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="103" mass="11090" checksum="8B3CD6CF075785CC" modified="2018-12-05" version="1">MNNMNQMMKQVKKMQEQMLKAQEELGGKTIEGTAGGGVVTVTVNGHKKVLNIVIKPEAVDPEDVEMLQDLVLTAVNDAISKADELANADMGKYTGGMKIPGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN99</accession>
    <name>A0A398CN99_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02719">
        <property type="protein sequence ID" value="RIE02719"/>
        <property type="gene ID" value="D3H35_18900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="74" mass="7907" checksum="620A85EF0DA2CF1F" modified="2018-12-05" version="1">MHGFAAAGIVVTGAIIVLWENLLAKERAAKAAVVTITACACILSIALLFMPELTGPTDWVMPLFRPIAKWIGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CND8</accession>
    <name>A0A398CND8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2975 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04876">
        <property type="protein sequence ID" value="RIE04876"/>
        <property type="gene ID" value="D3H35_05280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021354">
        <property type="entry name" value="DUF2975"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11188">
        <property type="entry name" value="DUF2975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="160" mass="17858" checksum="AF3DCB41067C6500" modified="2018-12-05" version="1">MKWGTTLFLKMAVILIGIPILALCIFLVPKIGNFAGELYPDIAYMKSLVLIDMFAAAIPFYFALYQAFKLLSYIDKNQAFSELSVKALKNIKFCAIAISTLYLLGMPLYYLMAEKIDPPSFMPLGLVIIFASMVIAVFAAVLQRLLQEAINIKSENDLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNV4</accession>
    <name>A0A398CNV4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FMN-dependent monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_02605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05046">
        <property type="protein sequence ID" value="RIE05046"/>
        <property type="gene ID" value="D3H35_02605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="4">
        <location>
            <begin position="28"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="154"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="227"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="463" mass="51628" checksum="E51D4A3738395C52" modified="2018-12-05" version="1">MSKRIRLNAVEMACPLQDNAGMWQLSGNSADRYKDLDYWVSLAELLEKGKFDAVFFADILGVYDVYKGSRDTAVREGLYVPMNDPAYVIPAMAVVTEHLGFAVTSSLTYDHPYSLARKMSTLDHLTDGRVGWNIVTSNLDSAARNFGLDGQIAHDKRYERGDEFLEVAYKLWEESWEDGAVIKDRGERVYTDPSKVHDIGHEGRYFRVPGIHLCEPSPQRTPVLFQAGSSERGRAFAARHAECVFLNAMNAEETRYLVQDIRAKAAAEGRNPDEVLFFPKINPIVGRTEEEARSKLDSYLAAASAEGSLSLLSAWTGIDFSTFGADQLLGFIKKGEERNGSSYLADFFSRNHTGAEWTREELAKYFAFGGAGSLLAGTPEQIADRLEAFVRETGVDGFNIAYVLRYDTFSEFIELVVPELQRRGLVQSEYAPGTFRDKLFGNGPRLPESHPGRQTRTGAEATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP80</accession>
    <name>A0A398CP80_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2798 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01707">
        <property type="protein sequence ID" value="RIE01707"/>
        <property type="gene ID" value="D3H35_12915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021529">
        <property type="entry name" value="DUF2798"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11391">
        <property type="entry name" value="DUF2798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="167" mass="18253" checksum="DF3E0732C9701839" modified="2018-12-05" version="1">MNQEARLPRNGKEGALYGAIICTLTVLLMTSLNIILAAGELNAAVALTILKSLPIIWVIVMIIEPVLIGRIAEKLVGKFTEPTDSFNAKILFRILFTVLGMSVSMTLIGDMVGNGFSSEIFSRFLGNWPRNFLIALIAESLVIQPIARLAMVKLHAAQDKRSQAVQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPI0</accession>
    <name>A0A398CPI0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lipopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_06680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04292">
        <property type="protein sequence ID" value="RIE04292"/>
        <property type="gene ID" value="D3H35_06680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="8">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="257" mass="28656" checksum="C476FC5185D31688" modified="2018-12-05" version="1">MSKELELKDYFRIVRKRLLLIVTIVIAACIVSGLYSYLVLDPVYQASTKLIVNKSNENAVVGQLDINTVNLNIRLIDTYKEIIKTPAVMDKVVAEHPEFGLTSEQLTSRVKVSSVNNTQVMTVSIQDLSYEKATELVNAISKVFIQELPTLMQVDNVSLLAAANPAKQPSPVAPKPVLNIAIAFIVSIMIGIGISLLLEYLDDTLRTERDVEQYLGVPTIAMIPRLKDEDIKSNKNRKSESLTQKGEHRVELHTQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPK3</accession>
    <name>A0A398CPK3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02648">
        <property type="protein sequence ID" value="RIE02648"/>
        <property type="gene ID" value="D3H35_18390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="160" mass="17921" checksum="19FF3E1C24D96E69" modified="2018-12-05" version="1">MAKLVFSVLMIVVWWTLHALQMDEEIALGTVHEAKRAVDRAAHAAALQLDRDKLELGVLSLSKDQAETAALSYLQANLRLDDSLLPLPGSPLQERVKVEALAVINENESFPYVYENPVFDYETILYRPGVVLIVHVAYPRMFGVLAPIEWDLMGSAELVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPU2</accession>
    <name>A0A398CPU2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04452">
        <property type="protein sequence ID" value="RIE04452"/>
        <property type="gene ID" value="D3H35_07665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="428" mass="45933" checksum="E5A867FF823645AD" modified="2018-12-05" version="1">MTQKQTQRPRSRMWPKLLSIALGTAALLTVFGIVRAPGEAFRASLSGLQIWWQYVFPGLIPPLVLAELLAASGLLHGLSMLAEPLTRRLFRLPGASGWAIAFGWSTGVPAGAKEAARLRGSGLIREEDTDTLLLVSHMPNPFLVIVIVGSGFLQSPALGWAIALGLWLSAAAAGIVWSRLAKSRTVKTPPLPVNQPRALMRRALRAAADARKEDGRPFGKQMADAVSHSIATLMVIGGLMMLSAVALQLIRASYPGTDVWLAIPGVYEMHLGAYETGHSMLFASAPVHAASLLAAALAWTGWSGLLQARAAFGTEGSFPWGRVIGGRLLHSALAMLFTWPLAQAVSGSGWLARFFDRLSPSSVEAVEAFSTGSQISLIPDAWRHIPEMWLAGLLSFGVFLLLALLAALIRPARKQHKQPPRPPSDHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPV8</accession>
    <name>A0A398CPV8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="4">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="4">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">truB</name>
        <name evidence="7" type="ORF">D3H35_11620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03329">
        <property type="protein sequence ID" value="RIE03329"/>
        <property type="gene ID" value="D3H35_11620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="5">
        <location>
            <begin position="33"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C_2" evidence="6">
        <location>
            <begin position="184"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="313" mass="34562" checksum="4B5F6AF869B4F96C" modified="2018-12-05" version="1">MRKRLPANSDGVLGVLKPKGWTSHDIVAKVRGLTGIRRIGHTGTLDPAVTGVLPLCIGRATRFVEYLQEMPKTYEARLRFGLSTDTEDLSGIVMEERDASHLTEVQMRSAVLSFIGDIEQVPPMVSAVKVDGKRLYELARQGVTVERKARPVTIHDLEVLEVTAGVAHPEIRFSVRCSKGTYIRTLCVDIGASLGVPAVMAELVRTESASLRESDCVTLEQIADLMELGTLENRLLRADRLLVHLPHTTAASPESEYALQGKALQAIRLRPVPDSEGIWRVYRSDGTFIGLFDYNRETGALRPVKVFHPQDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ25</accession>
    <name>A0A398CQ25_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_06785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04310">
        <property type="protein sequence ID" value="RIE04310"/>
        <property type="gene ID" value="D3H35_06785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017252845" evidence="2">
        <location>
            <begin position="26"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="227" mass="24646" checksum="4AF3C953A6A8AA95" modified="2018-12-05" version="1">MLASKRWFAALMFMVIPLVVIGCSGKSSIPVLDKVSTSTPVGIEKYDFNSKSQDALGENESDSLPLVSPVPTQEEQASESIRPAYNGGREDTSTPVTELESADSKVKARIDQSFEVRFNSLRSECKASGEQLIASIFNELNGKEEVSLSQLQSKYIGKVAKAEAACDAKFASLLGQAKAEYTKNDLPVVEMPAWKTDYEKEKASMRLSAAGKLLKAYQNSKGASESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ61</accession>
    <name>A0A398CQ61_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01114">
        <property type="protein sequence ID" value="RIE01114"/>
        <property type="gene ID" value="D3H35_22110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="191"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="394" mass="42942" checksum="B866A33AB5E0878F" modified="2018-12-05" version="1">MTTTLRRWIRALETDEREIIEVRRYLHRHPELSFEEHCTAAYIAERLRDYGLEVRTNVGGNGVLGFLQGGKPGRTLAFRADFDALPIQDEKEVPYKSTVPGVMHACGHDAHTAALLGVAGVLSRHRDELGGKIVFLFQHAEEKPPGGAKAMIEDGCLDGVDAVYGLHVSSEIPYGRVGLREGPAMAAVDAFTITIVGKGGHGARPHNSVDALVVGSQLVGSLQQIVSRRVNPLQPAVVTVGVFHAGTAFNVIAGKAKLEGTVRTFDRQVRRQIEDEIRLLVRGVCESAHADFEIDYLNGYPPLVNPSSEAGRVRALVGELFGSEAWIDLPQVMGAEDFAYYLEAKPGAYLHVGARNDEELTHYPHHHPKFDIDERALLAAGKVFLSLAAAEHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ90</accession>
    <name>A0A398CQ90_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_22310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01144">
        <property type="protein sequence ID" value="RIE01144"/>
        <property type="gene ID" value="D3H35_22310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="317" mass="35426" checksum="38A03F6DB4E7F073" modified="2018-12-05" version="1">MSSLSQLIRNENMKIYRRPRTWLMVGFLVLALLLMSGLIKWDSPSEDPNWKASLTAQNQQMQTQLQTDKELGAEHKEYLEKEVKLNEYYLAHDVNPNEQSLWDYVYYSSQLIILVTILTVIVAADMIAAEFSWGTIKLLLVGPASRSKIMLSKYIATMGFALLLLIVSFVVAFGAGAVLQGFDGVGAPHLSIGADGNVHESSMIGIALQKYGYSVVSLLIYVTFAFMISAAFRSSSMAIAFSLLFMLVGSSITMIFSKYVWVKYLLFANVDLTQYLEGSTPIRPEMTLSFSITMLVAYYVVFQLAAWILFTKRDVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQA2</accession>
    <name>A0A398CQA2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-isopropylmalate dehydratase small subunit</fullName>
            <ecNumber evidence="10">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alpha-IPM isomerase</fullName>
            <shortName evidence="10">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">leuD</name>
        <name evidence="12" type="ORF">D3H35_04265</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the LeuD family. LeuD type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="10"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04705">
        <property type="protein sequence ID" value="RIE04705"/>
        <property type="gene ID" value="D3H35_04265"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="11">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE04705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="199" mass="22569" checksum="33C82806506BB60F" modified="2018-12-05" version="1">MQPFTKLTGLVTPVDRVNVDTDAIIPKQFLKRIERSGFGQFLFFEWRWDEKGNVIPEFSLNQPRYQGSSVLISRANFGCGSSREHAPWAILDYGFRCVIAPSFADIFYNNCFKNGILPIKLSEEQVEELFQRTNANEGYELNVDLESKVLSDGKGLTIAFELDEHRRQFLLQGLDDIGLTLKHEAAISEYEAKRAAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQQ9</accession>
    <name>A0A398CQQ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_05330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04885">
        <property type="protein sequence ID" value="RIE04885"/>
        <property type="gene ID" value="D3H35_05330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="65" mass="7560" checksum="685B27F392CE007D" modified="2018-12-05" version="1">MKLGSSSIATQRHFLVVDADTVLIRPHRFYADGKHLFYCRSWSQPEYFVTYRKLLGKKARVPVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR27</accession>
    <name>A0A398CR27_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thiol-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_03700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04610">
        <property type="protein sequence ID" value="RIE04610"/>
        <property type="gene ID" value="D3H35_03700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="35"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="176" mass="19863" checksum="A6242C661A52962B" modified="2018-12-05" version="1">MKRHRKKLQYFILIAVIVIGGYAIGSSLFSKADILKIGDKPPEFKLLDLSGQVHSLEEYKGKPLILNFWGTFCPPCRDEMPALQEVYDSWKDKGVQLVGINLSENRLNVDSFIQMVGTNFPILLDKDRMTEKAYGLKQYPTTFFIDAKGKIRDIRIGGPLAADDIEAEIAKLLEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR58</accession>
    <name>A0A398CR58_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_16425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02307">
        <property type="protein sequence ID" value="RIE02307"/>
        <property type="gene ID" value="D3H35_16425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="127"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="340" mass="37850" checksum="627C5B159D69279A" modified="2018-12-05" version="1">MKLVDIELVEPGHTLGKSIFSANGTVLLSIGVQLTVFMISTLKRLGVTTVYIDDPLYRDITPEEVLSEETKRAVIHQMSETFEALRSGKTFSAKAISQTVDQMLDDVLTNQSVLIHLDDIRTADNAMFLHAMNVCMISSMIGLNMGLNMIQLKELAIGALLHDIGKLNAPEVQEGRMHHSWRGFDLLKHKWEYSLLIAHVAFQHHEAVDGTGEPRGIGSDEIHLYAKIVAVANYYDNLLFHQETPGRSLLPHEACERLNAMSETKLDHEVLVHFMRIVSIYPNGVSVRLSNRLIGIVVGQHRGLPGRPVVRIIDKDGDSSAAKEIDLAQHPTLFIESVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRJ9</accession>
    <name>A0A398CRJ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome C oxidase subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_01995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05163">
        <property type="protein sequence ID" value="RIE05163"/>
        <property type="gene ID" value="D3H35_01995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017353359" evidence="1">
        <location>
            <begin position="28"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Cupredoxin_1" evidence="2">
        <location>
            <begin position="46"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="137" mass="14449" checksum="48F29F424565AFEE" modified="2018-12-05" version="1">MKKWVAGLSFVLATVLVLSACGKSDNANEQSAQPTPSASTPANTDAAAAGAVKEFTLNAKNFEFDTTEIKVSKGDTVKITLKNSQGNHAVKISGYDQEIKNGETISFVADKTGQFDFLCSIMCGAGHTKMTGKLIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRK6</accession>
    <name>A0A398CRK6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01544">
        <property type="protein sequence ID" value="RIE01544"/>
        <property type="gene ID" value="D3H35_24650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017303609" evidence="1">
        <location>
            <begin position="27"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="323" mass="35498" checksum="86266B8A4D8C8A63" modified="2018-12-05" version="1">MKKRNQWLMIGGAAAAVTLFTATAFAYTPNTEGYNAFKEALKANQLSGKAFESATMNGNFTVTVDGKSVLAANGKTKVADAEDGHIVSSDFDFTLMGIARSGSLYSNGDESIYMVDRTHNKHYQVINTDEENAGKHRVRPYEDDSYDRSMSKAEEVLLDFIVGDLKDNFSVANHADGSKTITADIDEKDIPLPIRLLMDAAESNDRIERKHTEEVPAEWERVKQLPFFQGLKDINFEEQMPELTKDFAIEHVVLQFTVNADNELQSVQGELEVSGKDEAGVAHTVEIEGAGDVSGINATMPDVYDPAGKSIEIIDAATFEDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRT8</accession>
    <name>A0A398CRT8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YdcF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04900">
        <property type="protein sequence ID" value="RIE04900"/>
        <property type="gene ID" value="D3H35_04600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="52"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="210" mass="23147" checksum="A7FC26532D900154" modified="2018-12-05" version="1">MSSGKKKNVWLKRFAWLAAVGILAIAVWCGTLYSIIVRFDGIPNSGTPVQADVGIVLGATLWNDKPSPGLQERLDHALTLYRQGAFKQFIVTGGLDDNGATLTEAAGMRNYLVLQGVPEADIALDTESRSTYENLLFAKAIMDKRQWKSAVIVTHRYHGSRAGSIAKQLGYSPVQVSVTDSKVLKLSYHKTREVLAYTKWLLDKARMSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRU3</accession>
    <name>A0A398CRU3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_15075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02081">
        <property type="protein sequence ID" value="RIE02081"/>
        <property type="gene ID" value="D3H35_15075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="2">
        <location>
            <begin position="56"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="227"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="748" mass="87188" checksum="B88E984779510E53" modified="2018-12-05" version="1">MERSSMSEITINSKSYWDNRFRTNWEAYLGREQTAFFYHLALKMMPDWLLEEIERKQFSICDAGCAEGDGTQLLASRFAQSRVVGLDFSEEAISKAKSYYPDVLFQCSGIENMEERYDVILSSNTLEHFDDPFAMIRQMMNSVGSYLILLLPFEEYQRIPEHSYTFDYDVFPLKLNGFHLVFSQEVNCSVIPGTHWPGKQLLVVYANPERVRIEDIPLSSFYDPSRFNELQARIDAYVVEIGQYKDEIKGKDEEVLKRSVELQLAKDEIASLLVRIQEQRQELERKDQQLFALAGQLNEIHSSGFWKAATKYYRLRDHTPGLKYVYKTLRLWKREGLRVTIKRGSSKIKKAFQQPASLNKSHLTKMEEMLHIIKVRYENNELEGIAILPSAFEFEELYNQRTINLAKYLSKQNYAVLFVAWQWNHDEVLLKANQEVYRNVFELPLYGFLAGLDLLESLSSISRKLAFLTMPNETFYRTLPTLRAGNYSIVYDILDEWEHFHKVGQAPWYDKAIEEAFILNSDLVVTVSEPLKQKFSSLRNDIRCIGNGYDPSLLKADISLKTKAADGKIHIGYFGHLTDSWFDWGLVLELADRNSDMVFHIIGYGHPEFIEHEVKKRTNVILYGKVAPNELYRYVRQWHLAIIPFLGSQLSEAVDPIKIYEYLYFGLPAIVTGIPHIGNYPLVTYCEDKRNMAELLRSGYERLAAPEPERNGLDRFLAETTWDARFSEIMRLIPQIQFLQRIYDDNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRV1</accession>
    <name>A0A398CRV1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_17660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKC lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02517">
        <property type="protein sequence ID" value="RIE02517"/>
        <property type="gene ID" value="D3H35_17660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008844">
        <property type="entry name" value="Spore_GerAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038501">
        <property type="entry name" value="Spore_GerAC_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35789">
        <property type="entry name" value="PTHR35789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05504">
        <property type="entry name" value="Spore_GerAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="293" mass="33139" checksum="31298433AE2B4DA2" modified="2018-12-05" version="1">MRIVIVGDRYASNGLRPLLDFLVRVSYIRLRTNLFYVSGEAKEVGALAPVFERFPSEVIREFSHMGILPEVILKDLLYSEWNGLSDAYLPELRMRQGPVITEKMEGQKWIVSGRAALIKDGTKAAMFSDRGTRGIQWLADDKPQMIVTVPSPSDGKLISVLVQDTERKVSAERKGDEMIVRIGLRASGRLLSTESELDVTKADSIKLIQRAVSEEIKDQMEEAVALARDNQADPFQWSEIAEYRFPSLWKEWQPQLRERLADSVDARITVRFELKDTGSEKDAVYSRKSDGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRX4</accession>
    <name>A0A398CRX4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_08395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03969">
        <property type="protein sequence ID" value="RIE03969"/>
        <property type="gene ID" value="D3H35_08395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="3">
        <location>
            <begin position="257"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="5">
        <location>
            <begin position="311"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="4">
        <location>
            <begin position="333"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="516" mass="57710" checksum="6E27E11C4EC9F6B6" modified="2018-12-05" version="1">MEIYRAFSRQFIRNCTAGSTVSVLVVGSLFIFSTLEISQVEFLRLAGVLIGSLIIMMTLELFFIRRQIAPIRTLLHALESSDVPSDWSKVQSVYQHVHRLPVLTVGRILGPHLLGLSVPAILATLLLIRLDLLHFPYFYVWLAIAGSLLVAALHAMIEFFLTVQTIKPVLLYIRRRSLDLSGYDPSLNGQIIVSIQKKFQLSAFLIGAFPLFLFALAGQVRLQRLTGQDSMEYWRWAAVIIVIGVAFASLGAWLLSRDVQQPIRNLYERMGSVREGNFDVQAADIYSDEFSKLISGFNHMVNGLKARDRMNSQLIQSYITMLAATLDARDRYTAGHSERVAGYSVQIGWLAGLSLQELDLVKKSALLHDIGKIGVRDSVLLKEGRLTDEEFALIQEHPVLGENILKQIEPVDAMADLMPGVRSHHERYDGKGYPDRLSGDSIPLLGRIIAIADAFDAMTSDRPYRQGMSVEKALLILEEGCGTQWDPKLTPLFVADIREEQRRTKPTSSADAFKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS89</accession>
    <name>A0A398CS89_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_4-like_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05392">
        <property type="protein sequence ID" value="RIE05392"/>
        <property type="gene ID" value="D3H35_00990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="102" mass="11502" checksum="107113BA854824C0" modified="2018-12-05" version="1">MVEDRGASSGQQIRYRMKKTVEKLAYNRSDKFVVLSGYFQTVLEQEYGVASDRIHRIPGAVDTDRFRPADNRSKSEESWALRTAIGFSSAFGGSFEEWASIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSA1</accession>
    <name>A0A398CSA1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ala_racemase_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05090">
        <property type="protein sequence ID" value="RIE05090"/>
        <property type="gene ID" value="D3H35_02870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="1">
        <location>
            <begin position="30"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="311" mass="33178" checksum="7B204C20BF4A9E53" modified="2018-12-05" version="1">MHRRGRRPTCFLEGGCSMNKQDLDTPCIVVDQDKLKDNIARVQRLADEAGIALRPHVKTHKTPQIAGMQLNAGAVGIAVAKLGEAEAMADGGIGPILIAYPIVGKTKLERLMRLASRAEVTVAVDSLEAASGISEAALKAGIVIEVWIEIDPGYGRTGVQPGAALSLLGHELRTLKGIRVTGVLVFAGQSYDEDSDDGRARIAMREAAIASEAADTLRDMGFPIESVSAGSTPVSRFASAMKGVTEMRSGTYVFGDLTQVKAEAMSLEQCALTVLVTVVSRPRRTEPSSMQGPRCSLRTERIHRSARGEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSB8</accession>
    <name>A0A398CSB8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyl-accepting transducer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_00605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000006">
        <property type="protein sequence ID" value="RIE05422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05422">
        <property type="protein sequence ID" value="RIE05422"/>
        <property type="gene ID" value="D3H35_00605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="2">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="211" mass="22929" checksum="15B43B4823D04DD0" modified="2018-12-05" version="1">MVGDSEEMTAEMREFREAFVMIANMSKLIDDIASQTQLLALNANIEAARAGDHGTGFAVVAQEVSKLALQTRESAVRITEQMTAATRRSGRLEEAVERMKASVLESSSAMEETTERFKGFAKFIADTDGQLQRMNGNLRAVTDSTSSLSEAVMSTSAMVEQMAAGTEEALASVDVQQHNILSMNESFGKLSAPACRSVQPFPSSSFRQRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSC9</accession>
    <name>A0A398CSC9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_07835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000028">
        <property type="protein sequence ID" value="RIE04149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04149">
        <property type="protein sequence ID" value="RIE04149"/>
        <property type="gene ID" value="D3H35_07835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_molyb" evidence="3">
        <location>
            <begin position="265"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="420" mass="47498" checksum="494BD50A5E6D346E" modified="2018-12-05" version="1">MNENKKKTGFGKQLAELHRWNGWLVVLLAVTGLVLSWGAVRGWLGEGRVWIKQLHIGVGVVSGILLVMYAPLMRRHWKQIRNRPSQKRNLSVMLILLVGWLLSGIVLWQFRHLPPRWANNALVVHDLLTWVGMPYILFHSITRIQWMRRPERRTIRAEAGESAEALQPGGYRSPTPAQWVTRRQFLKWSFGVAMAVATVPPFFRWLGTVPGLGGASGGGTAGGMNDTSSGGNRMLPEPEPLPDSVRVIGGGAEGRFRVYTVTRLPSFDSQTWTFTLDGLVDRPAVWSWERFLAIARKVQVSDFHCVTGWSVYRNTWEGIPLSELLKLAGVNPKAKYVKFYSGDGEYTDALSLEQANMDDVMVAILHDGKPIHRDYGGPARLIVPKMYAYKSVKWLNRIELVDKPHTGYWEERGYDNDAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSD4</accession>
    <name>A0A398CSD4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000005">
        <property type="protein sequence ID" value="RIE05442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05442">
        <property type="protein sequence ID" value="RIE05442"/>
        <property type="gene ID" value="D3H35_00480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="290" mass="33973" checksum="B665737E4BDF373F" modified="2018-12-05" version="1">MESADEAFELATDVAFLMPVDPNIEKIQILLDAADDTSVEVEVWDTGRQENYIPYQLQVRDVQTIKKGNKQWIEFNLPWSPESTQNAFVVIKENPSVSVYLSHQPMSGVLSFVREKALNVARGMESLNHDQLVVKWNMKRVVRKPFCFRLATETKAYEPAKIMDGYQRPYGGAHMWLSEPSKDDAWVALKWDKEVEFNEIHITFNDDVNEDLINLHHHRTEFDVIPELVRDYRLEVFEKGNWRILFEVKGNRQRKRKHTLENDVRTEQLRLVVEQTNGTAYAEIVEIRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSJ2</accession>
    <name>A0A398CSJ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02767">
        <property type="protein sequence ID" value="RIE02767"/>
        <property type="gene ID" value="D3H35_19195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="68" mass="7471" checksum="ED539807F227C8B6" modified="2018-12-05" version="1">MHTSRTEVDGGQSESNCDAYEHNGGRRRAVGEFVMHTSTTQADGGQSESNCDAYEHNAGRRREVGEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT29</accession>
    <name>A0A398CT29_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03918">
        <property type="protein sequence ID" value="RIE03918"/>
        <property type="gene ID" value="D3H35_08100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="44"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="247" mass="27856" checksum="6D2B5AC027AA12C3" modified="2018-12-05" version="1">MGEWYEDSFGEDYIIVYRHRSLANAEREIRSMTGWMSLPEGAEVLDVGCGTGRHAEALRALGYKVTGLDLSPVLLNEAKKKDSKGLIKWVQGDMRSIPFADGSFEAVVNWFTSFGYFKDDADNDKALSEMSRVLVPGGKFLIDFLNAAHVKENLVPYSERLDGAAGLRISERRSIEGDFVVKRIEITPETGEPRRYEERVRLIGLERFRSMAKQTGLTIEAVRGGYEGESYDERKSARLIMTGRRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT81</accession>
    <name>A0A398CT81_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="9">3.5.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nagA</name>
        <name evidence="9" type="ORF">D3H35_17680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="9"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02521">
        <property type="protein sequence ID" value="RIE02521"/>
        <property type="gene ID" value="D3H35_17680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047419">
        <property type="term" value="F:N-acetylgalactosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="8">
        <location>
            <begin position="53"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="221"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="310"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="385" mass="41263" checksum="368812757C680A70" modified="2018-12-05" version="1">MKKLILTNVRVVTPERILDNGWIAYENGLVSAIGSGPADTAGCEVVDGRGGWALPGFIDVHVHGGGGHDFMDAEEDGLREITKFHASHGTTGIVATSLTASRDQLTEVLERVSRFMSKPMPYSQVLGVHFEGPFVNDKWKGAQNPAYIIPPQPEWLEEWVRRFPGIIKIQTLAPETEGALDYIERLAGHGIVPSCGHTDATYDQIIEAADHGLRHAVHMYNAMRPYHHREPGTVGAVLTDDRIVAEVIADGHHVHAAGIDLMRRAKGTDRVILVTDAMAAAGMPDGSYDLGGLPVTMSCGVARLTGSGNLAGSTLTMIGAFRHMVREVGVPLADASRMASGNPARQLGIDTVAGSLEAGKRADVLLLDDALQLERVWIGGAEIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT95</accession>
    <name>A0A398CT95_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_15695</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. EmrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02184">
        <property type="protein sequence ID" value="RIE02184"/>
        <property type="gene ID" value="D3H35_15695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="22"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE02184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="499" mass="52567" checksum="597A191BF8B1A5E2" modified="2018-12-05" version="1">MASNSNAAPSTGSLSMKQIIGPLVAIIVGLFMVILDGTAVNVALPQLAREFNQSNFSLLQWTVTGYALAQAAVIPLAGWLSDRFGAKRVFLISIGLFTIGSGLCALANSVEMLIAFRILQGLGGGVVMPISMAFIYRLAPSDKVGQVMGMMGIPILLAPALGPVLAGWLVEKATWEWIFLVNLPIGVIGVLLGIRTLPNIARQSVPGLDLPGIILAPIAFAALVYGVSEGGSFTAEGESKWTAATTLTGISVGVVALVLFVIIELTRKNPLLELRVFRSGNFTRGIVVQWISQMAMFGTMFLVPLFLQQAQGYSPIKTGLLMLPQALASAVFMPIGGKLSDKFGARPLVVVGMIITTGAAILLSNISADSSDLSIMLPLGMLGAGMGLFMMPLNTHLIQSAPQNLVGRVTSLTNATQQVMMSFAVAGLTTISTTRMQDLLIDQGKKAVDLPIYADAFGYTFGILMYVAIVGGVLGLLLKRPKNVSGEGEKGAEIHMMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTA7</accession>
    <name>A0A398CTA7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05390">
        <property type="protein sequence ID" value="RIE05390"/>
        <property type="gene ID" value="D3H35_00980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="99" mass="11029" checksum="E4261BC43180F1FA" modified="2018-12-05" version="1">MLDNAKRKAALLLHRFLQYWTTRAVKEQPRIDPTVYVMPNAYVSAEVAVGRYSYIRGGAQLESGSVGAFCSIAPDVLIAETSTRWTRCPLIRSGIRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTC7</accession>
    <name>A0A398CTC7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000006">
        <property type="protein sequence ID" value="RIE05410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05410">
        <property type="protein sequence ID" value="RIE05410"/>
        <property type="gene ID" value="D3H35_00545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="83" mass="9496" checksum="F18DEC05317504E8" modified="2018-12-05" version="1">MRQERCPSRRAAADFRIDAVGFEILCVNERQATAIFSDVSSRVLPCDFYPTKIEFGEQLVCPGCFQQFVDNQLAAWSRLEFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTT2</accession>
    <name>A0A398CTT2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_16805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02374">
        <property type="protein sequence ID" value="RIE02374"/>
        <property type="gene ID" value="D3H35_16805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="366"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="450" mass="50017" checksum="1C6B330534EA8E92" modified="2018-12-05" version="1">MHFDFLLEGFEQRRAESAIGWKDATYSYGWLLDRITEFEKRLEAEDGIAHSVVSLEGDYSPHTIAALFALIKLSSIIVPMDGNIPEAKRTEMLGVAEARTRVRAGEDGIEVISLDAEPPVNRWLDHLRQERAPGLVLFSSGSTGKSKAAVHHAGRLLWKFRLARSAKRTIPFMMFDHIGGLNTMLQSLAGGGCLYILQDRSPYEVCRTIEAHRIQALPVSPTFMNLLLLSGVHAEFDLSSLEVVSYGSEVMPESTLTAWKERFPSVRTVQAYGMSELGVLRTKSRTDDSLHFSLADDGVQYRIVDGMLEIKTATAMLGYLNAPDPFTSDGWLMTGDMAVEEGGFLRILGRRSDLINVGGEKVYPAEVESVLQLIANIEEVAVSGEPSAITGQIVKATVKLQGEESLKELRGRIWEFCKDKLPAWKIPQKIVITNDSMTSERMKKVRISQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUE0</accession>
    <name>A0A398CUE0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03467">
        <property type="protein sequence ID" value="RIE03467"/>
        <property type="gene ID" value="D3H35_12475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="341" mass="37020" checksum="4BA85C6A029476F7" modified="2018-12-05" version="1">MFARIGGTRYHSFGESGVPARIGGMRYHSFDESGVPARIGGTRYHSFDESGVPARIGGTRYHSFDESVVPARIGGTRYHSFDESVVPARIGGMRYHSFDESGVPARIGGMRYHSFGESGVPARICGMRYHSFDESGVPARIGGTRYHSFGESGVPARIGGMRYHSFGESDVPARIGGMRYHSFDESGVSARICGMRYHSFGESGVPARIGGMRYHSFGESDVPARIGGMRYHSFDESGVSARIGGMRYHSFGESSVPARIGGMRYHSFGESGVPARIGGMRYHSFGESGVSARIGGMRYHSFGESGVPARIGGITSILGLVRVRKLIRIEYILLSPDQETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUJ3</accession>
    <name>A0A398CUJ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_12320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03527">
        <property type="protein sequence ID" value="RIE03527"/>
        <property type="gene ID" value="D3H35_12320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="283" mass="31434" checksum="A0C27529717EB637" modified="2018-12-05" version="1">MTGSFTQAAESLRVSQPTISKAIKDMEEELGVHLFDRTGKKAELTNDGQTVLAQSRDIVQSFENLTTGLNPDARAQKGKLRIGLPPMAGAGYFPEIIGRFHERYPGISLELMESGARKIEDDIESGALDIGVVLLPTKQQHIYHTIPIADERLAVIVHVGHPLASRESVTLKELAGQAFILFQEDFALHGRISAACLGAGFQPRIVCESSQWDFIGNLVAAKLGISLLPKIICRRMSPDRITVLPLADPVIPWSLAFVWRKDRYLSFAAREWIRFVRTFYPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUM7</accession>
    <name>A0A398CUM7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1801 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02991">
        <property type="protein sequence ID" value="RIE02991"/>
        <property type="gene ID" value="D3H35_20530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="18"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="113" mass="12700" checksum="74D62F47A7FC8310" modified="2018-12-05" version="1">MNQEVTDFIEALQEPWQRELSARLREVVYQAIPAVQERIQYKKPHFLKNGKYAAVISTSKAAVSFTIFNASELTLPEDLFDGPPERKTIKLKQGQSFDADQLSSLVSQASASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW67</accession>
    <name>A0A398CW67_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04788">
        <property type="protein sequence ID" value="RIE04788"/>
        <property type="gene ID" value="D3H35_04755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="225" mass="25729" checksum="123E8C76562F8389" modified="2018-12-05" version="1">MQYVRIRSIEDKLFAAMHRLMGVVFPPEEVLAFELWKEPIEDPAIHVYVAIHEGEVVGATEYRYDPKLRVAMTDFTIIGRPDLGIGRFLYANREKDLSRLQKESGTIAIGMFAEIYDPRKDEAALPGAGNVNPMHPAVRREVLSHLGYRRLDIDYVHPSWDHEGKAVQGLDFCFRPADDEIVSIPAALVTTFLRQYYSALPNKPQEWFDMMANIELRTDIALLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX18</accession>
    <name>A0A398CX18_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03751">
        <property type="protein sequence ID" value="RIE03751"/>
        <property type="gene ID" value="D3H35_09340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="153" mass="18518" checksum="45E6CA2087EFF166" modified="2018-12-05" version="1">MNNEDYKLKHKADVFREGLQSLLKKYNPTHYAVIVSNIINEVFVNRKHMGRYPIHFLMHSIQANCSYYNSNRNDILTEIKLQRILNHYRQYFDPVAEYFLTKDDGVEPFFVNMARQQLSLQWATVQIRWEDQYYFLIKVIIRKVKNISKIRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX85</accession>
    <name>A0A398CX85_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05188">
        <property type="protein sequence ID" value="RIE05188"/>
        <property type="gene ID" value="D3H35_02120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="116" mass="13148" checksum="219B365B56D619DB" modified="2018-12-05" version="1">MTQSAEQPISLNKGTPGQPCPIASTLDIIGTKWTFLIVRDLLIDGTLRFSELLRSMEGISPKTLSLRLRELEEHGIVDRTVYPEVPPKVEYRLTDKGRQLEGVFIELKRFGLGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYB2</accession>
    <name>A0A398CYB2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_06220</name>
        <name evidence="2" type="ORF">D3H35_27425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000050">
        <property type="protein sequence ID" value="RIE00622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00622">
        <property type="protein sequence ID" value="RIE00622"/>
        <property type="gene ID" value="D3H35_27425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04211">
        <property type="protein sequence ID" value="RIE04211"/>
        <property type="gene ID" value="D3H35_06220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="92" mass="10338" checksum="65BB2A3E487A8819" modified="2018-12-05" version="1">MTLGRNDGSERKKAPVSNARFADVGTGARGSRGSTLLDFTTTIRRKILFFPWHVSLERRVRRSVRPGLHPPRLASLPTEPVTFSFIENDSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ30</accession>
    <name>A0A398CZ30_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04491">
        <property type="protein sequence ID" value="RIE04491"/>
        <property type="gene ID" value="D3H35_06900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="183" mass="21051" checksum="338352219DA27655" modified="2018-12-05" version="1">MEVKIDGEAPLICPSAEFQEHYMEFYRDWIDSGEHIVPWVVEKDPSDFGAFLNFLYAEDSEEKLADPNKVPHSTYWLLNEDDLLVGAVNIRHRLNAKLLSRGGHIGYGVRPAYRRRGYASAILFQVLQIAKRMEIEQVLVTCDKTNIGSWKTILKNGGVLESEFTEENGNVVKRFWIRMSETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZF9</accession>
    <name>A0A398CZF9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_06810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04314">
        <property type="protein sequence ID" value="RIE04314"/>
        <property type="gene ID" value="D3H35_06810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="309" mass="34776" checksum="6813FC007E901A54" modified="2018-12-05" version="1">MAILEVNGLRKTFGTVTAVEEISFGVEPGEVFTIIGPNGAGKTTTLEMIEGLQKPDAGTITVCGLDWRKDADRIKIKIGVQPQSSALFELLTVEENLGLFATFYPDPLKTEDVLRMINLTEHKNKRVKQLSGGQRQRLAIGLGMISNPEIIFLDEPTTGLDPQARRNIWDIILELKRIGKTTILTTHYMEEAEKLSDRVCIVDQGRVVTLDTPAALIDKLTKEREIRLTMLDGEEAAKETEWLALNQPAIARTEREGSTLRIWSVQPEETLYGIFGFTRERGYRVEQVSIRELSLEDVFIAFTGKEWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZV2</accession>
    <name>A0A398CZV2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04731">
        <property type="protein sequence ID" value="RIE04731"/>
        <property type="gene ID" value="D3H35_04410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="5"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="142" mass="16030" checksum="A29CD624F7C7B794" modified="2018-12-05" version="1">MAVNVYLNFNGNCREVVEYYAKVFGTESPQIMTFGQTPPDPNFTLPEEAKDLVMHTRLEISGSTVMFSDVFPGMPFIEGNNISLAVVDKNPDNLKTYFHQLKEGGKVTMELQETFWSKCYGSAIDKFGIHWQFSHDDGESGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZY7</accession>
    <name>A0A398CZY7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000005">
        <property type="protein sequence ID" value="RIE05427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05427">
        <property type="protein sequence ID" value="RIE05427"/>
        <property type="gene ID" value="D3H35_00405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="133" mass="14589" checksum="C0F4D9499530AF96" modified="2018-12-05" version="1" fragment="single">PDVSDNITLGSTLLFYTKDAGRPVKFVPPSFTKDITQTPIPIKRVLNSGDSGCHYGGSSGGAEDIDTLHDNERIRDELWSVIYGIWDYIKNSGKFEAETMTLEWVGSMPGKRETADSKGLCLKPERPGTPNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0D4</accession>
    <name>A0A398D0D4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">30S ribosomal protein S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_03790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04624">
        <property type="protein sequence ID" value="RIE04624"/>
        <property type="gene ID" value="D3H35_03790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="29"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="116"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="202"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="287"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="403" mass="43849" checksum="7387AA1F39C62108" modified="2018-12-05" version="1">MSEEINVQEAAAESVSQEALDNLVTLKKGDTVKGTVVKIEENQAFVSLGYKYDGVIPLRELSSVNLENASDAVQIGQEVELKVVSIDDEKEKLVLSKRQIDSTRAWDQLQEKFDNGEAFEVTIADVVKGGLVADVGVRGFIPASMVERHFVEDFSGYKGRALKVKVKEIDRENNKVILSAKDVLEAEYESKKQDIMAALQPGQVIEGTVQRLTPFGAFVDIGGIDGLVHVSEIAWQHVAHPQDVVSEGQSVTVKVLKVDPSIGKISLSIKAAQPGPWESASGQFQIGEIVTGVVKRLVSFGAFVEIAPGVEGLVHISQIAHRHIATPHEVLKEGQEVKAKVLDFNPAEKRVSLSIKETEDAPAGQERAPRAPRAPKEESNLPAPESMSFTLGEKFGDKLSKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D2Q7</accession>
    <name>A0A398D2Q7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Asparagine synthetase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_00835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05364">
        <property type="protein sequence ID" value="RIE05364"/>
        <property type="gene ID" value="D3H35_00835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="6">
        <location>
            <begin position="2"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="643" mass="71727" checksum="3899EE8B54D475B4" modified="2018-12-05" version="1">MSALAGLVRFDGQDAGAADGEAMMAAMHRYVADDVRTWSGGPAFLGSRIRWITPESVAERMPDGDPGSRIRIAADAILDNRRELFERLQVPPDRRASMTDSELILLAYRRWGREAPAYLIGDFAFMIWDEHRRLLFGARDLFGSRSLYYHCTERRFAFGTTMAPLFALRDTAKRLDEAWLAEFMAIPEMFESTDAGATPYRQVRQVPPGHTIAVSDGRISLRGYGTLEPDRPLRLKSDGEYEEAFRDVLGEAVRCRLRTFREVAATLSGGLDSGAVAGFAARALLQERKTLHAYSSVPTSDFTDWTPGSAAADERPFIQATVRHVGNIAETYLDFEGISPFTEVDEWLDLLETPYKFFENSYWLKGIHEQAGRQGAGILLTGARGNFTVSWGPALDYYALLLKQMKWLRLSRELRLYGANKGIGRRRLLPAIGRLAFPALARHSQQAAENDLPGMLIHPDFAERTGVFARLRSGAGGSAGANPFALRKEKLGSLAAANKNGATATKLSLRYGVWERDPTCDLRVVRFCLAVPVEQYVQGGMDRALIRRATGSVLPDEVRLNQRVRGIQGADWLHRVAPSWPSLTEEVERLCADSAVSGYLHVDRIRAAAAGIGKEPRPELAFHPEMRLLMRSLILYRFIKRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CC04</accession>
    <name>A0A398CC04_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000059">
        <property type="protein sequence ID" value="RIE00310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00310">
        <property type="protein sequence ID" value="RIE00310"/>
        <property type="gene ID" value="D3H35_29265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="192" mass="21307" checksum="010163318A06258B" modified="2018-12-05" version="1">MGNVRCQAECQLREVQRKETTANERECQFFLNNVKTALSLVAVGLLSAAPLAAGIPAWQADVTHAATYAYGYTKIIGYYDTIPNDFLATYASPFRDYKEITYVGGAKWPATKSHVTDTRIPDGWVITEKGSPYNPYAYAPPSYSTLVCINGAPKGTVLWVHPTSRIPSGWAITEISDHIFPEKRSMRIVRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CC70</accession>
    <name>A0A398CC70_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_26550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00756">
        <property type="protein sequence ID" value="RIE00756"/>
        <property type="gene ID" value="D3H35_26550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="152" mass="17187" checksum="C413519875FE8580" modified="2018-12-05" version="1">MAGFFDSGPLPAWKELRDLLGKDMPWKLVEQYDKADNAGWLDQFVKEMVSRASQQHSVESHKALASKVTKDAKRVTVTLDLPPGAMSRDLRLHASADRLKISGLPGERRQLLRLPCMVHARTGKATLKGNRLVVKFRRKPAEKNEVELFILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE40</accession>
    <name>A0A398CE40_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_26260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00705">
        <property type="protein sequence ID" value="RIE00705"/>
        <property type="gene ID" value="D3H35_26260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="74"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="296" mass="33218" checksum="DD92B9B00BF077A4" modified="2018-12-05" version="1">MISKTRNRWNRRIEFGVFVVPAIVCILLSAIVPFLMSLYYSLTKWNGVGKHIKFIGLKNFREILTSDTNALKALVFTLEYTLLAVVLTNVVAIVLAVVLTKALKLRGLYRTAFFVPYIISLIIIGFIWKFIFTKGFDVLYEATGWGVFHWSWLGNGDLAFWSILFVAVWQSVGFYMMIYITGLQSVPGDLLEAASIDGCVGINRFFRITLPLLMPSITVALFLSLANSLKVFDIIYTLTFGGPGGATTSVTMDIYNEAFVNNRFGYATAKSLLFVFLVLIITVVQVKFTKSREVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEI1</accession>
    <name>A0A398CEI1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00262">
        <property type="protein sequence ID" value="RIE00262"/>
        <property type="gene ID" value="D3H35_29985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="79" mass="9616" checksum="B5941E1153E355F2" modified="2018-12-05" version="1">MFRPRRHCRCRPSRRRPYPYRPYGPRLRINWLTIVFAGIGAILLLLLLNKFLILLIYTSGWLLLLAGIAWLIWSYWWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CER8</accession>
    <name>A0A398CER8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_28480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00362">
        <property type="protein sequence ID" value="RIE00362"/>
        <property type="gene ID" value="D3H35_28480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="319" mass="35787" checksum="88AA6B90B1A1B1C0" modified="2018-12-05" version="1">MGGRGRLHYRPELVRIDRQLFQFDSSRDQDQERQDGTVHLGVGVLGLAYNKELLAEVGYNEPPKTWEEFMDLGEKLKAKGKDLFAYGGKDETAIGNVLHWTFGDYAVKDPAFKEAYLSNTVDWSKPEYRSMLKEGLERFKQLNAYVRTGSFTNDGSFAQQAFAEGNVAVLFSGTWESGTLHKLNPDLKLGFMNMPYAPEEQNAYIFVPEDGMAANAKSKHPEEVKTFLNWLFSKETYAKIQKAKGSFSAMPGVGELDESYTDVPNWLNTDRVISFANTGPVPSPTWIALGNAAQEYTFKGDADKSIDKFITAYNKTKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFF6</accession>
    <name>A0A398CFF6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TlpA family protein disulfide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_14220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01926">
        <property type="protein sequence ID" value="RIE01926"/>
        <property type="gene ID" value="D3H35_14220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="58"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="201" mass="22512" checksum="59ED2691C9B573E8" modified="2018-12-05" version="1">MSITSSTWRFLMKRLRHWSVLVLAAGLIFLVLFQSLSDNRTKASRAQSAPAREAEEAPEIGYLAPSFSLAGIDGSLYKWRQFRGKPVVLNFWASWCGPCKDEAPSFVKLHDTYKKELTIIAINLTAADSEKSAREFADEYGFSFPVLLDKDGSVAKRYKIRPIPSTFFIDKDGYIVDGVLGSLGAEDLKIRAEKLLRPDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFS0</accession>
    <name>A0A398CFS0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prepilin-type N-terminal cleavage/methylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_23550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for transformation and DNA binding.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01350">
        <property type="protein sequence ID" value="RIE01350"/>
        <property type="gene ID" value="D3H35_23550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030420">
        <property type="term" value="P:establishment of competence for transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0178">Competence</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="140" mass="14607" checksum="D8C9D6C318B98AAF" modified="2018-12-05" version="1">MILAKARLLKNQKGMTLIELLAVVVIIGIIAAIAIPLIAGAVNNSRKSSDATSEKMIVEAGLRYIFDTPSFSSTTISVSDLVAKGYLQSAPIKQTGSDANKPYATFYVKQIGDSWAFDDGAGKGFTYGTVAGGSPSPSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGB0</accession>
    <name>A0A398CGB0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02256">
        <property type="protein sequence ID" value="RIE02256"/>
        <property type="gene ID" value="D3H35_16105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="420" mass="45864" checksum="A3F7251AD3B87A08" modified="2018-12-05" version="1">MNSMWTVMSFTMRNKLRSKSFIIMTVILAVLLVVVGNLPYLIDKLGGSDKATKVGYAEGEQAVIVQGLKDYYTKLPEPGVELVSVASADKLKSALQDGDIGGYLTFTEDPEIGFPKATYNSKDAFSGGTSSSLAAALQQIKTDLIVKDVGLTDAQKKQLFAPISLDTQKVSFDGEKGKTEEEQGIAIGLTYAMIILLFMAVMITGQLIATEITAEKSSRVMEIIVTSVSPLKQMWGKILGTFIVAIIQLAVLIGALVINLTMPQNADSLEKFGIHLDTIDPTLLVYAVFFYLAGFFLYSTLFAAVGSIVSRTEDLGQAILPITMLTLVGFYVAMFGLTHPDHILIKVCQYIPFFSPFLMFLRIGLAEPAWWEIVASIAILIVAILGIGWLSAKIYRTGVLMYGKRPSMKELVKAMKAYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGX5</accession>
    <name>A0A398CGX5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_29095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000057">
        <property type="protein sequence ID" value="RIE00329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00329">
        <property type="protein sequence ID" value="RIE00329"/>
        <property type="gene ID" value="D3H35_29095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="134" mass="15729" checksum="916296A522BD4017" modified="2018-12-05" version="1">MRNNGKIFEPQVVYNGVPIAGISGLRLYGIAPIGWSAVYSFYEWDGISPMKFTGFDNYIRMFTEDDVFWQVFKNNIVFTIVNVVFQVSVGLFIAVLLTKIKRAARFFRRSISRRWFFPRLRSFKSFRTSFPSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGZ5</accession>
    <name>A0A398CGZ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_17410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02476">
        <property type="protein sequence ID" value="RIE02476"/>
        <property type="gene ID" value="D3H35_17410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="74"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="290" mass="32456" checksum="80C9E7636B163593" modified="2018-12-05" version="1">MYHKTLSYRLFSVFNNALLTIISVVCLLPLFHLLMVSLSSTAPANAGLVTFWPIDFTFEAYAKTFENANFLSSLWVSVQRTLIGTALALFVNSIAAYALSKDTRIFRARNVYLWYFVITMLFSGGLIPGYILILKLGLMNTLMALILPGLVAVYNIILLLNFFRTVPKELEEAAFIDGAGHFRSFVSIYLPISLPALATISLFTMVGHWNAYFDGLIYIKESERLPLASFMQTIIVQADMTKFNPSMVANLSQRTIRASQIFIGALPILAVYPFLQRFFVKGVVIGAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH49</accession>
    <name>A0A398CH49_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagellar biosynthesis protein FlaG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02073">
        <property type="protein sequence ID" value="RIE02073"/>
        <property type="gene ID" value="D3H35_15020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005186">
        <property type="entry name" value="FlaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035924">
        <property type="entry name" value="FlaG-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37166">
        <property type="entry name" value="PTHR37166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03646">
        <property type="entry name" value="FlaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160214">
        <property type="entry name" value="SSF160214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="113" mass="12896" checksum="2851D6621DED5E7F" modified="2018-12-05" version="1">MEIQAVGDSSMFRDQQTIEKKPSGQEGTPSGKAQQEPTYGKADLKKELNHLNSWLQSKDAHLQFVLHDKLNEYYVQLVDNVTNEVIKEIPSKKMMDIVASFYENIGIIIDKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHC1</accession>
    <name>A0A398CHC1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_29330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000060">
        <property type="protein sequence ID" value="RIE00298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00298">
        <property type="protein sequence ID" value="RIE00298"/>
        <property type="gene ID" value="D3H35_29330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="218"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="402" mass="46259" checksum="3FA97F0C035AB371" modified="2018-12-05" version="1">MYGITETTVHVTYKQMKQTEIEGHISNVGQPLPTLHTYILGSDHKLRPVGVPGELYVAGNGLARGYLNRPELTAEKFVANPFAPGERMYRTGDLARWLPDGNIEYLGRIDEQVKVRGHRIELGEIETQLLKHESIRETTVLERKNKEGETYLCAYFVADKEISVMELRKHLSISLPEYMIPSHYMQLEYTPLTSNGKVDRKVLPEPDGRMTLGIVYEAPRNELEEEFVLIWQEVLHIERVGIQDNFFDIGGDSIKAIRLMSRIGTKLDQKVTIHDLYLHPTIKGFLEARSDIESSMMNANNLEFTAEIEHAIQNAAGIYGRALMENIEDIYPMSDIEQGMIYHNLINPESAIYHEQFVFPWKENYFSIDALERTLHYLVKKHSQLRSDFQYGESEIPMKIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHJ7</accession>
    <name>A0A398CHJ7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_27995</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00579">
        <property type="protein sequence ID" value="RIE00579"/>
        <property type="gene ID" value="D3H35_27995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002229">
        <property type="entry name" value="RhesusRHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00342">
        <property type="entry name" value="RHESUSRHD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017260686" description="Ammonium transporter" evidence="9">
        <location>
            <begin position="23"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="10">
        <location>
            <begin position="37"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE00579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="454" mass="47911" checksum="01EC9A35BD1A26FB" modified="2018-12-05" version="1">MVKKSLLALGALMVLFPTMAFAEDPSAATLNSGLSALWILVAGILVLLMQGGFILLETGSTRMKNAGHVAGKTIFTVGLASLVYWAVGYGFAFGGDAGESLNKFIGLGNFLYEPSFLAVDGENYPSSVFFVFQLAFVAVSLSIAWGGFAERAKLSVYLIFTLFFAGVIYPIVAHWIWGGGWLAADGSQDFAGSTVVHLTGAMAALAGTILLKPRIGRFNKDGSANEILGHNQVYTALSVLLLWVGWFGFNAGSWLAVSDGFFGFVAFNTQLGAAGGAVAALLISWLVLGKADITTTLNGALAGLVAITASCAYVEPWAAVVIGLVAGVLVFFSAKFFEAIRVDDPIYALSVHGAAGVWGTLSNGLFATKDLVTITNVGKSGLFYGGGWEQLWVQFESVVVCGAFAFVASFVVLWVMKQVVGLRVTEEQEIIGLDLSEHGTYGYPEQMKKAGTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHU9</accession>
    <name>A0A398CHU9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_28400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00458">
        <property type="protein sequence ID" value="RIE00458"/>
        <property type="gene ID" value="D3H35_28400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="338" mass="37154" checksum="2D02AF0908A1AE35" modified="2018-12-05" version="1">MKTLQELESKLAEPSEALVSMMKELDGDLLLLGIGGKMGPSMANLAINAIKQAGVSKRVIGASRFSSGTLREELEALGVETIAIDLLNDEELQKLPDVKNVIYMAGNKFGTTGKEHFTWAMNSYLPGRVAEKYRESRIVAFSTGNIYPFVPVLSGGADESVSPDPIGEYGQSSLGRERVFQHFSHLHQFPLSVIRLNYAIDLRYGVLLELAKSIQAGKPIPLAMGHFNCIWQGDANEMALRSLQIGKVGGELLNVTGPETVSVRWAASLLGDRLGIKPVFEGEESSNALLNNASYSHQIFGYPRVSLRQMIDWIAEWVTADAPTWNKETHFQERGGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHZ3</accession>
    <name>A0A398CHZ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NAD(P)-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_25160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01632">
        <property type="protein sequence ID" value="RIE01632"/>
        <property type="gene ID" value="D3H35_25160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="7">
        <location>
            <begin position="12"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="356" mass="38656" checksum="92F85F97EA447F15" modified="2018-12-05" version="1">MGNVMMNAAIMKDKLLIEVEQIERPAPGPNEALIKVQCIGVCGSDIHYYEHGRIGRYVVEKPLILGHEVAGTVVEVGSNVSNVKIGDRVAIEPGVPCGQCDYCKGGRYNLCADVFFLATPPDNGAWADYIVMRSDALFTLPDTMSFEEGALLEPLSVGYHAMNRANVKPSDKVFITGLGPIGLLAIQAAKLFGVKEIYASDVVAFRREFALKMGATAVFNPLEDSIAEELSVLTNNTGIDVVIESSGNRSSISSTMSLVRRGGRVVFVGLPPENEVLLNVDKIIDSELNLYGVFRYANTYAAAIQAYAKSGLNISEVITHRFELQEINAALHLARTQKDKAVKIMIYPESEAAPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHZ5</accession>
    <name>A0A398CHZ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_28100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000053">
        <property type="protein sequence ID" value="RIE00508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00508">
        <property type="protein sequence ID" value="RIE00508"/>
        <property type="gene ID" value="D3H35_28100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="123" mass="13035" checksum="6A8D393ACD98A2D9" modified="2018-12-05" version="1">MIRLTRPPLSRGRLVLIRTALLRAAAFGLRWSSFEYGFLPVPLAALVRLTGTRFLVRTGLRAERDRGRRPSATAAAAAFEGSDSGIGAAGITLSTIAGSIGSLATATMASVAQNPRLQWQLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI50</accession>
    <name>A0A398CI50_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00839">
        <property type="protein sequence ID" value="RIE00839"/>
        <property type="gene ID" value="D3H35_26555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019618">
        <property type="entry name" value="Spore_germination_GerPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37808">
        <property type="entry name" value="PTHR37808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10676">
        <property type="entry name" value="gerPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="76" mass="7506" checksum="7D72DB247DF2A3AC" modified="2018-12-05" version="1">MPCIIGAVKILSVAGIVQFGDAIQISPSSTSKTYAGAGSFITGDLSRSNNAVSSTNTNDPDVVDSSESTVGNGGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI91</accession>
    <name>A0A398CI91_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Intimin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Attaching and effacing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D3H35_17340</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the intimin/invasin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02463">
        <property type="protein sequence ID" value="RIE02463"/>
        <property type="gene ID" value="D3H35_17340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003344">
        <property type="entry name" value="Big_1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02369">
        <property type="entry name" value="Big_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00634">
        <property type="entry name" value="BID_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103647">
        <property type="entry name" value="SSF103647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51127">
        <property type="entry name" value="BIG1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017246068" description="Intimin" evidence="10">
        <location>
            <begin position="39"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1280"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1304"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1340"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="domain" description="CBM21" evidence="13">
        <location>
            <begin position="37"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="CBM21" evidence="13">
        <location>
            <begin position="151"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Big-1" evidence="12">
        <location>
            <begin position="262"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Big-1" evidence="12">
        <location>
            <begin position="357"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="11">
        <location>
            <begin position="907"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="664"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="683"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE02463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1517" mass="164069" checksum="3E72CE436988D0A9" modified="2018-12-05" version="1">MEKKEKGSMKMRKWIVWSIIFAMLISLMPSAFDRSASAQSNAGQVKLLFAKTVKGCPSGCYEFSGAVEVANLAYQKQVYIHYKTNNGQWSDIPAAYAGKTEGNLEAWTFKQIIADTTSPVQFAIKYVVNGQTYWDNNNNQDYRIGGSSAPDRILAKSFVALDNAGYGPMNSFSGRIYLKNIAYSKQVKIRYSTDNWASYLEQPAAYAGMLPNSNNSLEYWDFNVNLPSHAGDVKFAIAYMVNGVTYWDNNFKQDHRIGKPALLTLTSPAGPAPVGLPTTARLRVLDTFNNPIRQTPVLLSATGQAALPASVTTDMNGEANVPVSNERAETTTVTATIGGSAVSGSTSIQFVPGMPYSLSLQAEPASLSVGQLANIKATLHDRFGNGIPDYTLQLTATGSLAVPASAVTDYLGEAVFQASNTAVETSVITVSTASGPKAVTQITTTVPAVGIMFDKPAIDLFEDETEQLNVIFTPDNSSNKKVAWSSSDSTVASVTSEGLVTAHAEGTATITAVSEDGGHTATSTVTVNSSVPQPPVVGMQTYDGFVVLNWAADNKMTYTVKRKGFGEYKDIATVSSSVYEDRSIVIDGGYHYTVVVTNRKGESAVSNEVYAEVAIPDSDSDGLNNNLEASYGTNPQLADTDGDGLPDGCEIIILKTDALLPDSNGDGTADGLEDADQDGLSNTDELALGTNPLQQDTDKDGLLDGFEVHTFGTDPKNPDTDGDGVTDGQEFVLGTNPLAADSDGDGTADNEESYAQTTVASLDNETANPNNIATQVAVSFEGQPGKTTITNMFGKDYGTSRVAGLASDPVDFHTDGSFDQATITFAYDESLLGATNPNDLAVAWFDEDNQRIELLPSTVDTVNHTVATEVTHFSQYLLIDRKEWFDAWRQELPYKRGSGTPETQYYDIVFAIDSSGSMDWNDPTNLRQEAAKKFVQAFLSEDQGAVVDLDSYATIKIHLTKNKDSINGAIDSIDSSGGTNIDSAVNAGIDELLSGYAQPRNKKIIILLTDGEGTYYSSTTTRAIQNQIQVYTVGLGYSIDTVLLNSIAQQTGGKYYQIATSDQLKDAFDRIEDDTIGQIDPTDLDEDGLPDTVETIGMRTYWGEIIHTDPTNPDTDGDGVLDGYEADEFIAPQVPSPYPPQYGVTRYPYFTFISDPRYADVDEDLINDDYDDTPYESDLPDFSFIEDFFEESALGQSLSFLAEKAGHNNIEDGLVEYVKNTVRTLRLYRLTDEDIAMFFEGVMVGVDDNLFFGAAQGIKDLTVGYIPPEDNYYFMRGKTYTDAAFIAGFAMATFGSGDAARASFALAGIAGTMALATSALALTGGGIVVSGALATEAVTAAAGGLVLAGVALVTETMYLRSQDILKADSAKLSSAVASDNSAVWSKMAPVERGKFFNDKYGHNLDVPPCNCFPVMDHLDSVNRIIKSRKSIDQSLKSYTSLKKALRQELRRINRFKRDHRMGVEVTEDAYDSKTFEIVLRKDIALTPQQWDDINDARKYAEEISKGNKPISINIILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIC6</accession>
    <name>A0A398CIC6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00939">
        <property type="protein sequence ID" value="RIE00939"/>
        <property type="gene ID" value="D3H35_25595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="149" mass="16724" checksum="6CEF27E438A52970" modified="2018-12-05" version="1">MELEKCTGNHHPKWFGLAVQALIILSKENIQTCPSVEIAAYLQSEATLLRRILAVLAREGFLETREGRDGGYRLKRTPESITLAEVYDAFQTGQPLCYGIKETTGTHPFGVEMKAAFCELTNEMNQSLRSTLSRYTIADLADRMLTNTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIK2</accession>
    <name>A0A398CIK2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_27345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00678">
        <property type="protein sequence ID" value="RIE00678"/>
        <property type="gene ID" value="D3H35_27345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="368" mass="42504" checksum="F30940FA9A5F2A4A" modified="2018-12-05" version="1">MLRAIIVDDEELSVKRLNRMLSGSGVVEICRTFQNPLDAYEFVKSHADSVDIAFLDISMPEIDGMSLSARLRALDRSMDIVFVTGYDEYAVKAFDMDALDYLLKPVTAERVAQTLSKLGRMQRVAAAEPALEVQLFNGLRIYRRAGSKELLKLRSPKTEELFAFLVCKGTVSREEVIETLWHGLEPEKAWKNLNSTLYYIRKAISGIKMENGIIADRNEIWIDESLIHSDLRQFEHLLKRIQAAPETSGEWLPQAEALYAGPFLKGKAYEWATDKARKLERDYIGLLELSAMEHRRHDRLQQSLHYFNEALKLDPLREDLHYEVIALYAALGRMNEAVKQYNALEEWLHRELGMKPESRLEEIMKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIU1</accession>
    <name>A0A398CIU1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FMN-dependent monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_22135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01119">
        <property type="protein sequence ID" value="RIE01119"/>
        <property type="gene ID" value="D3H35_22135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="145"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="217"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="443" mass="48736" checksum="0E1AC0558913E7BC" modified="2018-12-05" version="1">MAKQRKLRLGAVIHGVGSSVSAWRHPDIQSDASINIGFYRQQAVKAEEGKFDFAFIADGLYINEHSIPHFLNRFEPITLLSSLAAVTSNLGLVGTLSTSYSEPFNVSRQFASLDHISGGRAGWNVVTSPGVGTAANFNKGGHPEHASRYEIAEEYLEVAKGLWDSWEDDAFVRDKESGVFFDPEKLHRLDHKGTHFSVQGPLNIARSKQGQPIVFQAGSSEAGRNLAAKTADAVFTGHETIEEAQAFYADVKQRAAAYGRSPDSILIFPGIGPIIGATLEEAELKYEETANLGSIEDALRYLGRFFDHHDFTQYPLDEPFPDLGELGSNGFKSTTDRIKQKAKEHTLTLRQVALRSTTPRSSFIGTAEKVADEIQRWFETGAADGFIVGSGVPNGFEDFVDQVVPILQARGLFRVEYEHDTLRGNLGLPFPINRYAKQTVTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ07</accession>
    <name>A0A398CJ07_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_22645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01199">
        <property type="protein sequence ID" value="RIE01199"/>
        <property type="gene ID" value="D3H35_22645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="96"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="2">
        <location>
            <begin position="863"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="975" mass="107195" checksum="B060FE3B21A6CE12" modified="2018-12-05" version="1">MEAIMIIPEIKVKWEKYVLTMLIAAVIAIGMTFSAASADASSDRVVTDGHTPEEIIAKWDEYKPTFSGDPFLVKPNVTAPYATGKLNPAFIQDGVNMANFVRFLAGLPDDLEQDQSLNDQAQYGAVVLAAVDTLTHYPAKPKDMDSGFFEIGAKSTSSSNLHAGLTKLHQTVLGYMSDSDSTNIDRVGHRRWILNPPLKKVGFGYALSNTATAYSPMQVFDKSGAKTSASPITAWPSPGAFPMIAFDFGDAWSVNLNKEQYESPTLNEVKVNLKRITDGREWNFDYNDKGSPDMSRNYFNVEGSGFGAGSSIIFRPADAGAPSDQDVYEVKIEGIKTISGEAATISYTVSFFDIPGKDNAAEYLAQWRLPREAKSQLPIKFKSSTVEQWVRLKLGINQAVITEAALSRISDFYFDYNNGDTSLDEDILPKLTGLRSLNFQSLGEAGVAPIANLRGLTELSVATSFAEKPIHELQLLANLKQLNKLSLYGSIPEGDLSQLLGQLPNLRQLTVEDDQLTDLSFIPPTVMANLVELTVTSDGLRDVTALRYANKLLNLSLQGNDVPLLDLRPITSLSGLLWLGVNSFGITDADVVKISRMTGLTTLSLRNNQIRDISPIAALTKLEDINVSGNKIRDVSVLSKLPSLKWIDIGFNGIYDISSVMNADFDIQQLSVRANFLDLTEGGRTKVWLDKLATKPIYLSSVGGTVTGNTAFYDSQQQNELWYYEWSDLTDRTFDSRSLVVGDSIPAKIIARYVDYNDQVIDNSSEWVSSDPKVLMIKNGKITALKSGYASIKIKWGDVEKNVWFNVISRPNMGYYYSKALTDTMKAQLQNALVLGVGNGTILADGTLETTDAKPFVDKASASTLLPVRVVSENLESSVTWDKKTQTAVVTNYDGSIRIEIRIGEKTMKVNDKVVDLPVAARIVDSNTYLPLRALCDALGKQITYHNGVIAIANHSFYKEAELLNTLSKMYSLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ14</accession>
    <name>A0A398CJ14_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BlaI/MecI/CopY family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_22700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01209">
        <property type="protein sequence ID" value="RIE01209"/>
        <property type="gene ID" value="D3H35_22700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="120" mass="14039" checksum="725BF5322BECFF3C" modified="2018-12-05" version="1">MKNLKLCESDYRFMLVVWENEPLASGQLVTLCSEKLGWKKPTTYTVLRKMCEKGLLKNEDTIVSSIIPKEQVQAYESEYFIERTFEGSLPQFLVSFFGNKPLSKKEADELKRLIDEHKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ52</accession>
    <name>A0A398CJ52_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02365">
        <property type="protein sequence ID" value="RIE02365"/>
        <property type="gene ID" value="D3H35_16760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="179" mass="19704" checksum="82E0613BA56E61CB" modified="2018-12-05" version="1">MSPFFAASYVLLWLVVFLLAYIVLAMAKRIYRISLPASDRGIQVGVSFPFPNMKAFQRRRLGAGSVSSGGTLVFFTASDCDACKRVYPVIDQFQRANANYDYALFMVASEEEGASILEPYANAFEAAFVDDLAPFEVPGVPFAYYLSAEGKVLSKGIFHEALHINHLIATGKKANRKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJS5</accession>
    <name>A0A398CJS5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02392">
        <property type="protein sequence ID" value="RIE02392"/>
        <property type="gene ID" value="D3H35_16925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="230" mass="27296" checksum="1782DA8EF1038B81" modified="2018-12-05" version="1">MSTKKGIFERMIELASDKNSLYYISNKQYFPLPLRISRCRGLSSQEKLVLMELLYCFGDNDEAFPSIEYLAFQLDVDDKTVSKNIRKLIEKKFISVYKAPNRVNRYYIHLLDSNPSITLSELTLWFEKTVQTRGIPKQDLVSQVHKELRRVTESEEYTSFLSRLMIVCVELMKGWNEYCKRPEAFYAKSEYDKWCRQEREILNEYLDYLNQAMTNKFGNNIRIVQPLVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJY2</accession>
    <name>A0A398CJY2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MBOAT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_18425</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02655">
        <property type="protein sequence ID" value="RIE02655"/>
        <property type="gene ID" value="D3H35_18425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024194">
        <property type="entry name" value="Ac/AlaTfrase_AlgI/DltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028362">
        <property type="entry name" value="AlgI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500217">
        <property type="entry name" value="AlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016636">
        <property type="entry name" value="AlgI_DltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE02655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="461" mass="53160" checksum="1F7F22C1F9024348" modified="2018-12-05" version="1">MIFSSIEYIVFLCVVILSIALLKTNQLKKIFLLVASYFFYAWWDWRFTALMFLLSFVNYQIAIQIERTSTRKKYWLIISVVFNLVILGFFKYFNFFIDSANQLLNEFGTSLPLLSIILPVGISFITFEVMSYVIDVYRGENKSSKSFIDLALLVSFFPHLIAGPILKPKHFLPQLKEEIKIRASNIITGSQIFIFGLIKKLLIADRLAYFVDPVFANPQQYSSSTVWLAVIAYAIQIYCDFSGYSDMAIGSAKMLGFDIPKNFNLPYLSRNVTEFWRRWHISLSSWLREYLYFSLGGNRKGKAMTYINLIIVMVLGGLWHGASWNFVIWGMLHGIGLVVHKLFMKIKFERSYIAYSFFSWLITFLFICITWVFFRSSDFSVSSQIINKLLFVSSGGTIWYATSLIAIIPIVIAAHFIGKKINNYLVVDIFSFKGLFLLSFVIVGIVILLPGNSSPFIYFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK02</accession>
    <name>A0A398CK02_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe/B12 periplasmic-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_22580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01188">
        <property type="protein sequence ID" value="RIE01188"/>
        <property type="gene ID" value="D3H35_22580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017385914" description="Fe/B12 periplasmic-binding domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="164"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="424" mass="46298" checksum="BB03AA60C8F067AE" modified="2018-12-05" version="1">MIKSTFRTMALCLSFLLAIVSVPFAATAAAAPIKVVLDGQQLTFGVQPQVINGTTMIPYSAVASKIGAAVSFNSQTKKVTVTRGKTTVVLTLNSNQATVDGKAVTLSTKVIAKNGSTLVPLRFLGETFGLWVNWNAGTKTASIETKRTITDAMGQKTLTSVPKRVVVLFNGMVDISLTLGVKPVGAVESWVQTPWYHYLRADMAGVKNLGSELQPNIEAIVALKPDLIIGAKTRHEKILGQLSEIAPTVLVGQLFEWKSNMDLAAKALNKEDKAASFMNDWNKRVADFKAKVGNRANTEVSIVRFYDDNSARIYITGFAGSILEELGLKRPKSQQSPDKVFVDLASQEQIPLIDGDIIFDITSSNHGGDEFKTQDEWQKNPLWSNLKAVKNGKYYKVNDITWSMSGGATAAKMMLDDLFFYFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK14</accession>
    <name>A0A398CK14_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_17445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02482">
        <property type="protein sequence ID" value="RIE02482"/>
        <property type="gene ID" value="D3H35_17445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="127"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="127"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="226" mass="25764" checksum="275F7AD0B2490EAF" modified="2018-12-05" version="1">MEKVLIIEDEQPLARFLELELRHEGYSVEVCHDGREGLDKALTQEFDVILLDILLPGINGLDICRSIRIAKNTSIIMITARNAVLDKVTGLDFGADDYMTKPFAIEELFARIRSLKRRAVPSFAAHMPVYRVGDLVLEPATHLVRRADTPIALSTREYELLLYLLTRQNVVVSRDQCLQDVWGYEFSGGTNVVDVYIRYLRAKIDDPFPTKLIHTIRGFGYVIRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK52</accession>
    <name>A0A398CK52_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ParB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01248">
        <property type="protein sequence ID" value="RIE01248"/>
        <property type="gene ID" value="D3H35_22930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="1">
        <location>
            <begin position="91"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="148" mass="17188" checksum="B9A778D0E95EE319" modified="2018-12-05" version="1">MKYGSTKIAMAYAERGAIAEWIQLFLRNDGKNVALADGLLLEQRYYIGPIITDISAFGIEEGAPSYLTDVNDIAWFFHVVDRMKEMIGDWDMPPLIVQYDEDQYEINDGRHRNEALRQLKITNAPVVFWMSSEEDHRFIVEQIRGDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK83</accession>
    <name>A0A398CK83_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_25025</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01609">
        <property type="protein sequence ID" value="RIE01609"/>
        <property type="gene ID" value="D3H35_25025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031621">
        <property type="entry name" value="HisKA_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16927">
        <property type="entry name" value="HisKA_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="358"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="488" mass="55684" checksum="C767D3F7366B9581" modified="2018-12-05" version="1">MNSTVELVFMIASLIMMGVILFFVYGFRRERGVRYLIGVIVCRIIYSSGIIMERSSDLLDEKLFFRHIQSTAMNLMVPFFLLFVYQLIGREKLVKPLWKIMLIAVFALWSLLSWLDPELHAIYRTIQLDNGHLITTRTPYSVAFSVTCYGILAVCLYFLFQYIRNIRSDFRKPGMWVLLLASLPIVLEIAKLANPVSSSWLLPFSVYCGFTGTVMLAITLRIKFFATVPIARNIVMDTLQESMVIANASGKIIDSNKRASEWFSEIGYGAVDGRNIAELLAAWPEWHKLCTSMQQGRVEIDAWLDGERKIYSVNVYPLRILRKQGQGSISLIVDITEKQRHLEQIAQLNRLKDQLITIVSHDIRSPLAAQFQLVELLEEDRESFGADHREIVEMLGSQIRNTLGMTNNLLEWFRSQREDMTLRPQSLELAEVVEECCQVLLINSEAKQISVNNGIGLGTRVYVDREVLGLIIRNLLSNAIKFTGLGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKJ6</accession>
    <name>A0A398CKJ6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 5">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rfbB</name>
        <name evidence="7" type="ORF">D3H35_09745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 5"/>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03826">
        <property type="protein sequence ID" value="RIE03826"/>
        <property type="gene ID" value="D3H35_09745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="6">
        <location>
            <begin position="4"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="329" mass="36408" checksum="DAFC1132255AC6D4" modified="2018-12-05" version="1">MNVLVTGGAGFIGSNFVHYMMRRYPDYRIVVLDKLTYAGNLDNLADVASLPGFVFVRGDIGNGGLVEELLSAYRIDAVINFAAESHVDRSIADPSVFVVSNVLGTQTLLEAARKAGVGKFVQISTDEVYGTLGSEGLFTETTPLAPNSPYSASKAGADLLARAYYETYGMNVNITRCSNNYGPFHYPEKLIPLIVTRALQDQAIPVYGDGLNVRDWLHVRDHAAAVDLVLHNGRPGEVYNIGGNNERTNLDIVRFVLGQLGKPETLIRYVEDRLGHDRRYAIDAAKIRAELGWKPEVDVERGLQETIHWFVNHRDWWQGTSSGERSYGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKJ7</accession>
    <name>A0A398CKJ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-IIB family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00417">
        <property type="protein sequence ID" value="RIE00417"/>
        <property type="gene ID" value="D3H35_28820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="166" mass="18421" checksum="86A822981B7829F9" modified="2018-12-05" version="1">MARPAHLSKSDPSGSNPSSSNCEYHAHIEESIATIQMQHPLHDSAYFLGRNIYQILLFCTVEEEERYRKSFPELEFVRWHSVSMDVLPHGGSKAKGIEAIIAERGILREDVVAFGDYLNDIEMLKFAGTSVAMGNAPDIVKSAATHVTRNVDDDGIWHGVRIAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKK4</accession>
    <name>A0A398CKK4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">M23 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_09795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03836">
        <property type="protein sequence ID" value="RIE03836"/>
        <property type="gene ID" value="D3H35_09795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="4">
        <location>
            <begin position="254"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="359" mass="39598" checksum="4FBBD7EC10B67242" modified="2018-12-05" version="1">MRYEHSFSRIKVNRTRSTAKQKRSPMKGETMTASKRKPRWSFLLIRGPGQQVKRIQVSGKTVFIVPVAAALTIAGVIAGLELKSLYRIQELESLIARQSEQLSGSENGKDEEIGTLRQELASLNEQADDLKTRMQGLRELETKLRQFIGKQESALPGLTDDSYRTSSILAESSVAAAKSTEDGVSDESMASAIADFEELSELLDSLADTMASNLRKARQRQAEIESRPSGWPTVSRKLTSGFGYRRDPINGRSTFHAGIDISGDEDDPVFAAGSGTVKETGFNSSRGNYIIITHRSGLESWYMHLRRISVKTGAIVGRGEVIGRLGNTGRSTGPHLHFQVVVQDEPVSPLPYLRMVKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKX3</accession>
    <name>A0A398CKX3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF423 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_08380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0382 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03966">
        <property type="protein sequence ID" value="RIE03966"/>
        <property type="gene ID" value="D3H35_08380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="PTHR43461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="123" mass="12827" checksum="038FF435EDF046DB" modified="2018-12-05" version="1">MNRYVQIGAVAAMLSVAIGAFGAHALEDKLSAHYMDVFETGVQYHMAHALGILLVGLLMDRLASSKLAIWAGRLLTAGIVLFSGSLYVLALTEVKVLGAITPLGGVAFIAGWVCLALAARSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKZ9</accession>
    <name>A0A398CKZ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_14105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01909">
        <property type="protein sequence ID" value="RIE01909"/>
        <property type="gene ID" value="D3H35_14105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="440" mass="47674" checksum="0FE0DF1F8E1CC898" modified="2018-12-05" version="1">MSDQANPQRKWRFDTLQVHGGQQPDPATGARAVPIYQTTSFVFKSTEHAKAVINFDEVGNTYTRVVNPTNDVLEQRIAALEGGVGALAVASGSAAVTYSIFNVAGAGDEIVSASTLYGGTYNLFDVTLPKLGITTRFVNPDDPENFRKAINDKTKAVFIESIGNPRLNVLDIERIAAIAHENGIPLIVDNTFGTPYLIRPFDHGADVVVHSATKYIGGHGTSIGGLIVDSGKFDWTGGKFPGFTEPDKSYGGLQYVEKFGELAFITKVRIQFLRDIGAAISPFNSFLLLQGIETLSLRVEKHLSNARRVVDYLNNHPDVAWVNYPGLESSPYYELAQKYFPKGPGSIFSFGLKGGYEAANRFIDSLELFSHLANVADAKSLVIHPASTTHAQLSEEELLAAGASPDLIRLSIGIEDPDDLIDDLEQAIRKASVVVEEAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL11</accession>
    <name>A0A398CL11_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FMN-dependent monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_08660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04016">
        <property type="protein sequence ID" value="RIE04016"/>
        <property type="gene ID" value="D3H35_08660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="150"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="222"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="455" mass="50723" checksum="0184A5BE08E53C8C" modified="2018-12-05" version="1">MTTKSKQRKLRLGAGLHGASGNFAAWRHSDAPADASIQFPYYKRQTLKAESGKFDFVFVADGLYINEKSIPHFLNRFEPITLLTALGAVTSNIGLVGTLSTSYSQPFTVARQFASLDHITGGRGGWNVVTSPLEGSALNYGKKLSEHPDHEKRYKIAAEYLQVTQGLWDSWEDDAFVRDKESGVFFDPEKLHTLNHEGEYFSVKGPLNIARSRQGQPIIFQAGSSDRGRNLAAASADGVFTDHKTLEIAQEFYRDVKRRAKEAGRDPDEVLIFPGILVIVGETEEEAVRKYEKVAELVSIDSALNYLGRFFEHHDFTQYPLDEPFPELGELGKNSFQSATDKLKREAKEQGLTLRQVALRTATPRSLFTGTAATIADTIQEWFEQEGADGFIVVGGEPNGLDDFVDKVVPILQERGLFRTEYESDTLRGNLGLPIPENRYTKRKKELVPAANPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL35</accession>
    <name>A0A398CL35_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alkylphosphonate utilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_12890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YjdM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03115">
        <property type="protein sequence ID" value="RIE03115"/>
        <property type="gene ID" value="D3H35_12890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004624">
        <property type="entry name" value="YjdM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013988">
        <property type="entry name" value="YjdM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013987">
        <property type="entry name" value="YjdM_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30305:SF3">
        <property type="entry name" value="PTHR30305:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03831">
        <property type="entry name" value="YjdM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08274">
        <property type="entry name" value="YjdM_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00686">
        <property type="entry name" value="phnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjdM_Zn_Ribbon" evidence="3">
        <location>
            <begin position="5"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="YjdM" evidence="2">
        <location>
            <begin position="47"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="114" mass="12490" checksum="7BF093513E60B4D9" modified="2018-12-05" version="1">MSSNLPNCPSCNSEYTYEDGSLLVCPECAHEWSLESSSDNSVDEKIVKDANGNVLHDGDSVSVIKDLKVKGTSLVVKIGTKVKNIRLIDGDHDIDCKIDEFGAMKLKSEFVKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL44</accession>
    <name>A0A398CL44_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative tRNA (cytidine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.207</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (cytidine/uridine-2'-O-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trmL</name>
        <name evidence="4" type="ORF">D3H35_08890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could methylate the ribose at the nucleotide 34 wobble position in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43088"/>
            <dbReference type="Rhea" id="RHEA-COMP:10333"/>
            <dbReference type="Rhea" id="RHEA-COMP:10334"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74508"/>
            <dbReference type="ChEBI" id="CHEBI:74511"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43084"/>
            <dbReference type="Rhea" id="RHEA-COMP:10331"/>
            <dbReference type="Rhea" id="RHEA-COMP:10332"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.207" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04056">
        <property type="protein sequence ID" value="RIE04056"/>
        <property type="gene ID" value="D3H35_08890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18094">
        <property type="entry name" value="SpoU-like_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01885">
        <property type="entry name" value="tRNA_methyltr_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016914">
        <property type="entry name" value="tRNA_cyt/urid_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42971">
        <property type="entry name" value="PTHR42971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029256">
        <property type="entry name" value="SpoU_TrmH_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00185">
        <property type="entry name" value="tRNA_yibK_trmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR029256-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="157" mass="17852" checksum="1D40E74CB6C1385C" modified="2018-12-05" version="1">MPFHIVLVHPEIPANTGNIARTCAATGTHLHLVRPLGFSTDDRELKRAGLDYWYAVNITYYDSFEEVEQAHPESRFFFASTRADKRYSDFEFRDGDMFVFGKETKGLPQELLDANPDTGMRMPMTDKVRSLNLANSAAIVVYEALRQTDFPGLLDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL85</accession>
    <name>A0A398CL85_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02972">
        <property type="protein sequence ID" value="RIE02972"/>
        <property type="gene ID" value="D3H35_20430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="179" mass="20612" checksum="FCA371C5C310729B" modified="2018-12-05" version="1">MTEGRHFITPEGVIFLYEIFTKIDLEMVDIEVAINYILVRDHWPEYPIFINYFQIREAGNLKKLFSLLAAAVLCLSFSTSVFAHSFEYSTTRDNVRTQVYTYSASHSHSSLLLTTYSWDNTDYHPSISVLVTASGHDHYGTLSKFAASSSSPYHYWTSSYCYIDTTFTGFYKGYVYDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLB5</accession>
    <name>A0A398CLB5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative manganese efflux pump MntP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mntP</name>
        <name evidence="9" type="ORF">D3H35_14510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probably functions as a manganese efflux pump.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MntP (TC 9.B.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01979">
        <property type="protein sequence ID" value="RIE01979"/>
        <property type="gene ID" value="D3H35_14510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01521">
        <property type="entry name" value="MntP_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003810">
        <property type="entry name" value="Mntp/YtaF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022929">
        <property type="entry name" value="Put_MntP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35529">
        <property type="entry name" value="PTHR35529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02659">
        <property type="entry name" value="Mntp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="186" mass="19430" checksum="A4BF47FE51E99ABA" modified="2018-12-05" version="1">MLEMSVATGQLLTILVMAAALGMDAFSLGVGIGLRGVRIRDVLKLSAIIALFHVLMPLAGMATGQYVSGLLGGVATSVAGGLLLLLGGHMVYSSLKGEVVDTIDHRTIWGMLVFAFSVSIDSFSVGVSLGMFSAHRLLTVMMFGFFGGLMSVLGLMLGRKISRSLGGYGEAFGGVILFAFGLLFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLD4</accession>
    <name>A0A398CLD4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit B</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoB</name>
        <name evidence="4" type="ORF">D3H35_14630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01999">
        <property type="protein sequence ID" value="RIE01999"/>
        <property type="gene ID" value="D3H35_14630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0408">Iron</keyword>
    <keyword evidence="1 2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="3">
        <location>
            <begin position="46"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="172" mass="19060" checksum="B25B623613BD9CC1" modified="2018-12-05" version="1">MELDLTNVSPEEKEELERNIFFGTIEQLKGWARSNSLWPLTFGLACCAIEMMAGGAPHYDLDRFGVMFRTSPRQADVMIVSGTVTKKMGPLLKRLYDQMPEPKWVIAMGSCATAGGPYVRSYSVIKGVDQIVPVDVYIPGCPPNPAALIYGINKLQEKIRYEAKTGKRVTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLF3</accession>
    <name>A0A398CLF3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03493">
        <property type="protein sequence ID" value="RIE03493"/>
        <property type="gene ID" value="D3H35_12660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="91" mass="10588" checksum="C6E59C38C803622B" modified="2018-12-05" version="1">MPDLINFDLVKLVKVTLHYADEANGIDETKDFLFKKGAQEAKWEFTYKDKSKQVYEWRASYFMVDGSVKNIEPGNTSEKTIVLPETPARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLK4</accession>
    <name>A0A398CLK4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Homoserine kinase</fullName>
            <shortName evidence="11">HK</shortName>
            <shortName evidence="11">HSK</shortName>
            <ecNumber evidence="4 11">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">thrB</name>
        <name evidence="14" type="ORF">D3H35_27635</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="4 11"/>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00521">
        <property type="protein sequence ID" value="RIE00521"/>
        <property type="gene ID" value="D3H35_27635"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="12">
        <location>
            <begin position="99"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="13">
        <location>
            <begin position="223"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE00521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="347" mass="36856" checksum="724396B35EEA1585" modified="2018-12-05" version="1">MNSETNRTDRKDVKEAAIRPDRAVVVKVPASTANLGPGFDTLGMALSLYAWVSLRPSSETRVTLVGGNLDGVAVDKSNLIYEVAQSVFRRVGVDIPELDIIIKSDIPLTRGLGSSASAIVGALVAANELIGGVLSEHELFQMATALEKHPDNVGASLFGGIIASAWDGTRAEAVRLEPPAGMDVLVAIPAFELSTKKARNVLPQSVAMGDAVFNVSHSSLLTAALATGRLDLLKMAMRDRLHQPYRAALIPGMTTILEEATNHGALGAVLSGAGPTLLMLTDRAEARGGELESFVREVMAAEGIEVDARWLEPCLHGPAHWELDTSAADYREQLGRLLEAAPEEVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLT0</accession>
    <name>A0A398CLT0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000051">
        <property type="protein sequence ID" value="RIE00601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00601">
        <property type="protein sequence ID" value="RIE00601"/>
        <property type="gene ID" value="D3H35_27465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="96" mass="11131" checksum="772A558580D91795" modified="2018-12-05" version="1">MLVSFKLRIVHQEERKHIKLVYDRSEATQRTYAPQSFIGLLVADLEKGKHFVEVDLDDPFFRVFTVSAERPLTSGGSACIRRTCRSITEIRPIRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLZ3</accession>
    <name>A0A398CLZ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01888">
        <property type="protein sequence ID" value="RIE01888"/>
        <property type="gene ID" value="D3H35_13990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017262362" evidence="1">
        <location>
            <begin position="28"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="221" mass="24595" checksum="B45F3BF695D6E617" modified="2018-12-05" version="1">MMKKRTPRLLAAAVFAAVLTLPAVANAASAEPAAVAAPALKTKFEAEGAFAALQIGEQVHVYNKDGQLFKTKGPWREGDLKDLFILPYGPEQIPFVLIQHDKYGYMVFSDLWPKFAKGKEKDTEEAYYSGRIFYKAQTRIDGKTRHHYAIQKGDEVITYIANDFDNLKKGYHEGYRVKGKLRGLVLYDCCPYTVVDSADGKLSVYHAGEKGATLSGHIDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CME7</accession>
    <name>A0A398CME7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_16965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02399">
        <property type="protein sequence ID" value="RIE02399"/>
        <property type="gene ID" value="D3H35_16965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="201" mass="23551" checksum="C857BA4F6B707A3D" modified="2018-12-05" version="1">MVRTRDEGFNEIIQTAERLFLEKGFEKTTVQDIVQRMGIAKGTFYHYFKSKDELVDHLLERYSDRLIHVMEMTARNSQIDAIHKFEQMAKSFIYFEGWNSDLMSYIHQNESLVLNHLFEIRCNNEIKPLVQSVIEEGVEAGLFNVEFPKQTAFMIVAVFDCIFDDDRLRSGVIEPEVLAAMEDFSNRLLGTKQKFKFSKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMH8</accession>
    <name>A0A398CMH8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1697 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01097">
        <property type="protein sequence ID" value="RIE01097"/>
        <property type="gene ID" value="D3H35_22015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012545">
        <property type="entry name" value="DUF1697"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36439">
        <property type="entry name" value="PTHR36439"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08002">
        <property type="entry name" value="DUF1697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008502">
        <property type="entry name" value="UCP008502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="187" mass="20719" checksum="53EE884D55AE91E9" modified="2018-12-05" version="1">MTIYAALLRGINVGGNHLVKMADLKKLFEGLGLARVQTYIQSGNVLFDSAEEEAPLRLRLERELEAACGFPIPVLLRTAAELRDIVANCPFPEEELAQAAANSKGETLYVSMLLEPPANDALERLRPYANEDDRFRDVGRDIHFLFGSGLSDSKLGNNLQKLKLPTTMRNWKTMNKLVALSGAMESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMP9</accession>
    <name>A0A398CMP9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_14995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02068">
        <property type="protein sequence ID" value="RIE02068"/>
        <property type="gene ID" value="D3H35_14995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysacc_synt_2" evidence="2">
        <location>
            <begin position="8"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="337" mass="38591" checksum="C585597C77C4DB69" modified="2018-12-05" version="1">MNYEGKKILIIGGTGTMGQLLTRHLLLHNPQVIRIFSRDEYKQFEMQRVFSEHSSRLRFLIGDVRDGQRLIRAMENIDYVFHLAAMKHVPFCEYNPFEAVQTNIIGTQNMIQAAIQNGVKKVLFTSTDKAISPTNTYGASKLMAERLISSAEYQKGPKQTTFAAVRFGNVMGSRGSVIPLFYKQILENRSVTVTDLSMTRYMMTATQAVTLMLKANEISLGGEVFVLKMPTILLADLVDVLIEEVSQKHNLTDEIVRREIGLRPGEKRYEELMTEEEKLHAWETSDMYIVPSPFKEQSQSDRYPDACLMQSSEVSSHRELPIDRDTLRKWITEERLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNE0</accession>
    <name>A0A398CNE0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03832">
        <property type="protein sequence ID" value="RIE03832"/>
        <property type="gene ID" value="D3H35_09775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="63" mass="7443" checksum="335D09BCBD4DB1B0" modified="2018-12-05" version="1">MNIDNPESFYCIVCNRMYRQDKAYLLFRTGFFRVMYPLGCCLSCRAAIQFDEGRFKPIAKDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNI6</accession>
    <name>A0A398CNI6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">walK</name>
        <name evidence="14" type="ORF">D3H35_24290</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01477">
        <property type="protein sequence ID" value="RIE01477"/>
        <property type="gene ID" value="D3H35_24290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="205"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="11">
        <location>
            <begin position="262"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="12">
        <location>
            <begin position="325"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="384"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE01477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="609" mass="66869" checksum="B1B336D4C5391829" modified="2018-12-05" version="1">MNLLRMFRSIQIKLIFIMLLLILIAVQLIGVYFISTMKNSLIDSFTNNLDSQASLLTSYSAQVLTQEDKNEDPKSGVSEKLNGMVSSLNSLNGAEIQVLDAGGRVLSTSKTSEQTVVGRKNTSLLVTRALQGIRDNEEEIIDEDNVRKKVIAMPVSSNNKIVGAVYIVASMRDLYETVEGINRIFYTAILIALGLTAILGVLLAGTITAPIKALTRQAAAVAEGRFDQRVPVFGNDEIGHLSVAFNDMTDRLSEALRINEEETEKLASILSNMSDGVLATDELGRVIVMNRRARILLGKQEMEGRTLSEALGTGKEPIADTLKGQESSLMLRQEAGEDGEEPLFRVTLTPIRRRDKGVAGAIAVIQDVTEFEKLEQSRREFVANVSHELRTPLTTIKSYAEALDDGAMDERSLAERFVGVIRSETERMIRLVNDLLHLSRFDSGRVLLRRQQTVISDMLEEVVDRFSFQLRQKAITATVRVEPNVESVWLDRDGIDQVLDNLVSNAIKYTLDGGTISLTAARNDSGQLELCVQDTGIGIPKKDLARIFDRFYRVDKARSRNMGGTGLGLSIAQEIVRAHGGTVALDSEMGAGTSVTVLLPIVQEGSEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNQ8</accession>
    <name>A0A398CNQ8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-amylase</fullName>
            <ecNumber evidence="3">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_16725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02358">
        <property type="protein sequence ID" value="RIE02358"/>
        <property type="gene ID" value="D3H35_16725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017312170" description="Alpha-amylase" evidence="5">
        <location>
            <begin position="37"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Aamy" evidence="6">
        <location>
            <begin position="73"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="552" mass="60551" checksum="49FFE03313ABA51F" modified="2018-12-05" version="1">MSKRPLAGRVGNLALVVTMAAAVLAGCSGNNEKQPAASPSSQATKDNATPSAKPYVIDTNVPAMGTSSGVFYEIFVRSFSDSNGDGIGDLQGVTNKLDYLQQLGVKGLWLMPITPSPTYHGYDVTDYYSVNPDYGTLDDAKKLVDEAHKRGIKVIIDLMLNHTSSKHPWFIDSAKNVDSKYRSWYTWAEKGSDTSALGPWGQQVWHTSAGGNSYLGVFTDGMPDLNMDNPEVRAELVKAGQFWLKLGMDGLRLDAAKHVYEDFQSSTSDPETSKKNQAWWQEFRKGMDEVNKDAYLIGEIWDSLTVVGPFLNHALNSGFNFDAAKLLIDSAKTEQAGAISSVLSKMLAYYSKQSEGQFVDAPFLSNHDQNRIMSELGENADHAKMAASLLLTMPGNPFLYYGEEIGMKGIKPDELIREPIIWAADRKSDGQTSWESTESNETTLSVEEQLQDPKSLLNHYKKLISWRNEEPTLGNGGIESFPIDESGVLGYLRVDSSSTLLVVHNLTGKATKVDLNANGTVPFSTLKHFSEEGTSLNAGQLELPPYSTVILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNR1</accession>
    <name>A0A398CNR1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_07885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03880">
        <property type="protein sequence ID" value="RIE03880"/>
        <property type="gene ID" value="D3H35_07885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="62"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="453"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="554" mass="60799" checksum="9A0A4E8CAE958012" modified="2018-12-05" version="1">MLYEAGRFAPSDRIASAGAGSFSEACEGERMDEAIGRQFRSIPLRWRGARRPMKDVSKSIARWASVQPQRPAVVDENVALSYGELDEHAGRWIGFLQSAGVAPGDEILLLLDNRAEFVAVLIAAVRADFVPIALNVHFTAEDIASLAARTRASILITTRTFANERDFEEKLSFRVYCLEELDLCDYPNCAGSATELGSDIVFFSSGTTGAPKGIVVPKSVFDMALPPADSGTAPQAHLLCRPLFFRAHLTAACNILQEGGTVVLSGQADFDAWINAMALRRVSFVSMGPIDLMGLLKFFERTGAKFPSSVNHLMITGAPLPDSLKATVTRRMPDLKVTDLYGTSETGAIAMIDNDEWAARGGSCGKPAFFLHAVVRGENGKELPAREVGEVWVKTRYRMREYYGDPAATSETIEDDYIGTGDLGFLDEQGYLHLSGRKRDLINRSGFHIFPEEVENVLRAARDVEDAVVVGLDHPERMQEPVAFIRLRDQGRKDGSSESAKIQELLAHCESRLARYKVPAAVWFVQDIPVNAAGKADRRRLAQRAVLPREGTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP73</accession>
    <name>A0A398CP73_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01697">
        <property type="protein sequence ID" value="RIE01697"/>
        <property type="gene ID" value="D3H35_25010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="SSF50985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="408" mass="40064" checksum="3450948374C98060" modified="2018-12-05" version="1">MLGWLVPYGSHSAYASQEGVRSTEGIRMAAGAAHSLLLKSNGTVVAWGARSNGQSTVPGDLTDAIAIAAGNYFSLALKSDGTVVAWGDNGYGQTAIPDEAATGGVVAIAAGGSYSLALLSNGTVIGWGDNSKGQRSVPAGLTDVIAIAAGNEHSLALKSDGTVVAWGDSNQGQTTIPAQLATGGVVSIAAGAYHSLALKSDGTVVVWGLNNQGQTTIPAQLATGGAVSIAAGGDSSLALKSDGTVVAWGSQGQTAVPAGLTDVVSMSAGWSHSLALRSDGTVVAWGDNSEGQTTVPAGLSSPIKGKNIASGGNSSIALKSDGTVIGWGSTGSGQLNIPAGLSGVAAIDKGNLHGLVLKSNGTVVAWGYNYDGQATVPAGLNGVVSIAAGNAFSLALKSDGTVVGWGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP83</accession>
    <name>A0A398CP83_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="11">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">rlmN</name>
        <name evidence="13" type="ORF">D3H35_07350</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="11"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04393">
        <property type="protein sequence ID" value="RIE04393"/>
        <property type="gene ID" value="D3H35_07350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="104"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="168"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="223"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="11">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE04393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="355" mass="40469" checksum="7984606E4CB488CC" modified="2018-12-05" version="1">MKKEIKPEKPFIYDYTLEQLQDWIKEQGEPAFRAGQIFDWLYVKRVSSFDEMTNLPKPLREKLEAGFGFVTLTEITHFRSKDGTVKFLFGLHDNHAIETVIMRHNYGNSVCVTTQVGCRIGCTFCASTLGGLKRSLTAGEIVAQVVKAQQLLDPENERVSSIVIMGIGEPFENYEATMTFLRNMIHPKGLNIGQRHITVSTSGIVPNIRRFAEEDTQINLAISIHAPNDALRSKLMPVNRRFPFEDVIDACKYYIEKTGRRITFEYALIGGVNDRAEHAEELADVLKDMLCHVNLIPVNYVPERDYVRTPRDDIFEFQRIMQKKNVNCTIRREQGHDIAAACGQLRAKHMEATTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPH5</accession>
    <name>A0A398CPH5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01817">
        <property type="protein sequence ID" value="RIE01817"/>
        <property type="gene ID" value="D3H35_13565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017309464" evidence="1">
        <location>
            <begin position="30"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="145" mass="16738" checksum="F36885655C24595F" modified="2018-12-05" version="1">MKTVRWLATILTLFVIISLFALMPPRASATANNDNVIENWHLQWIPAGSSTDNIPLLNGTWLDADVDNPQTTLPDGTIGMWVHFVMPSTDNWQRPGILIERLYLDISVFEGSRLIFESNRDFIYEEISYCCLSTRFLLRRIIMFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPL4</accession>
    <name>A0A398CPL4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_00715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05346">
        <property type="protein sequence ID" value="RIE05346"/>
        <property type="gene ID" value="D3H35_00715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE05346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="212" mass="23636" checksum="5317610F59B8DE74" modified="2018-12-05" version="1">MQIEILLVEDDPVWRVMLTRFINNEADLHVIHAVETKEAAVLYCADNDVDVVLMDINLSGNNLDGIQATLELSLSGSSAKVIALTSLNDESVILDAYTAGVLHYVSKGDFRKIPYVVREVMNSASSQEILVKEYKRLKEAEQYSKLTAAEKEIVMLCEAGNGRAFIMDALGKAEGTLKNQITSILRKFNVRSMKDAIRKIKSRGLDIRETDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPL5</accession>
    <name>A0A398CPL5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00894">
        <property type="protein sequence ID" value="RIE00894"/>
        <property type="gene ID" value="D3H35_25305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="76" mass="8504" checksum="107DB36993F4ECC3" modified="2018-12-05" version="1">MPSFREAVAAVNTELRKRRASFRQLSMEEKPQNTVWLPTQEAATEQLGAEFGGRIASLLSRMESEGRARIALKANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPQ3</accession>
    <name>A0A398CPQ3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">ATP-dependent DNA helicase RecG</fullName>
            <ecNumber evidence="3 7">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">recG</name>
        <name evidence="10" type="ORF">D3H35_07400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 7"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04402">
        <property type="protein sequence ID" value="RIE04402"/>
        <property type="gene ID" value="D3H35_07400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004609">
        <property type="entry name" value="ATP-dep_DNA_helicase_RecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045562">
        <property type="entry name" value="RecG_dom3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033454">
        <property type="entry name" value="RecG_wedge"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19833">
        <property type="entry name" value="RecG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17191">
        <property type="entry name" value="RecG_wedge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00643">
        <property type="entry name" value="recG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="274"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="454"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="684" mass="77120" checksum="5052EDCB0E741302" modified="2018-12-05" version="1">MSDDLFAIPVAKLQGVGSRKAEELHALGVFTVGDLIDYYPFRYEDYRIRALHEVKDGEKITVLGTIAAMPTLQRYGRTARLMCRVMVEGLLLTAVWFNRAFLKEQLTPGRDIMLTGKWDQRRRQLTVAESEFPDRAGQAKSGTLQPVYSVGGDITQAWIRKTIDKALTQYGALIPELLPADIVAKHDLIPRREAVIRIHRPENSQEGQEARRRMVYEELFLFQLKLQAYRAANRKQPDGLAHKVNNDEIRSFVGALPFELTASQKQVLNEILHDMKQPFAMNRLLQGDVGAGKTIVAAVALYATIRDGNQGALMVPTEILAEQHTRSLTKLFEPYGIQIGLLTGSLSDRKRRDILAALQMGLIDILIGTHALIQEDVFFRRLGLVVTDEQHRFGVNQRGILRRKGLNPDVLTMTATPIPRTLAITVFGDMDVSTLRERPKGRKPIKTYWVKHGMMDRVLGFIRREAEAGRQTYFICPLIEESEKIDVQNAIDLHIQLKQALPQLGIGLLHGRMTAAEKEAEMGAFSAGETDVLVSTTVIEVGVDVPNATLMIVMDAERFGLSQLHQLRGRVGRGEHQSYCVLIADPKSENGQERMKAMTDTDDGFEIARRDLELRGPGDFFGTKQSGMPEFRLANLVEDFAVLEQARDDAAELTNREDFWSSSSYARLRDYLQRELREQNEPMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPR0</accession>
    <name>A0A398CPR0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ParA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01441">
        <property type="protein sequence ID" value="RIE01441"/>
        <property type="gene ID" value="D3H35_24050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="2"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="257" mass="28218" checksum="2F44A78F490B029C" modified="2018-12-05" version="1">MSKIIAISNQKGGVGKTTTAVNLGACLATLGRRVLIVDIDPQGNTTSGIGINKADVEYCIYDVLINEVHPKQAIADTGIENLKIIPATIQLAGAEIELVPTMSREIRLKKSLALVRHMFDYILIDCPPSLGILTINSLTAADSVIIPIQCEYYALEGLSQLLNSIRLVQKHLNTSLQIEGVLLTMFDARTNLGIQVIEEVKKYFQQKVYQTVIPRNVRLSEAPSHGQSIITYDPKSKGAEVYLELAKEVITYEQAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPR1</accession>
    <name>A0A398CPR1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PUD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_07450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04412">
        <property type="protein sequence ID" value="RIE04412"/>
        <property type="gene ID" value="D3H35_07450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10315">
        <property type="entry name" value="CBM41_pullulanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005323">
        <property type="entry name" value="CBM41_pullulanase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03714">
        <property type="entry name" value="PUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="PUD" evidence="2">
        <location>
            <begin position="65"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="192" mass="21297" checksum="63C80D9D9970E7F7" modified="2018-12-05" version="1">MKKTVMANALTARLKRGDMSGMKERNGMSKIKSGFRIGVMLWVLCCFIGVLPVSAKTTETGTTKVTVHYKQKEGDPIDWSLWVWGDSENGVRLPFTGTDEFGKVAEIELPGKFHKVGIIVSTDDWKKDGGDRFVEIVNGSGEISITGEGYIEDTSGRDVPYLWLIVGVVVIPVLLHIFEYIRSRKGREAKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPT9</accession>
    <name>A0A398CPT9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FliA/WhiG family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_11510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03309">
        <property type="protein sequence ID" value="RIE03309"/>
        <property type="gene ID" value="D3H35_11510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012845">
        <property type="entry name" value="RNA_pol_sigma_FliA_WhiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02479">
        <property type="entry name" value="FliA_WhiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="5">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="262" mass="29976" checksum="856CF224CD742758" modified="2018-12-05" version="1">MVDQTRSRLSHQELWKSWKKDGNPDSRKRLIEHYLPLVEYVSSRMAVGLPKNVTKDDLASNGAMGLIDAIEKFDYERGLQFETYASWRIRGAIIDGLRQGDWVPRSVRDKAKKMEDAYAVLEQRHLRSATDEEVCSYLNINEKEFQQMLQEVAVAAVCSLEDPIREEESETRLSLLVDDKAPSPESKVHETYLKDTLVFGIGKLTEKERTVVSLFYYEDLSLSEIAEVMSLSPSRISQLHSKAILRLRGALAKQKEQLLQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPW5</accession>
    <name>A0A398CPW5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Ribonuclease J</fullName>
            <shortName evidence="9">RNase J</shortName>
            <ecNumber evidence="9 10">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnj</name>
        <name evidence="13" type="ORF">D3H35_11680</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9 10"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03339">
        <property type="protein sequence ID" value="RIE03339"/>
        <property type="gene ID" value="D3H35_11680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001587">
        <property type="entry name" value="RNase_J_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004803">
        <property type="entry name" value="RnjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01292">
        <property type="entry name" value="UPF0036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="12">
        <location>
            <begin position="22"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 11">
        <location>
            <begin position="368"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR004803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR004803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE03339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="559" mass="61250" checksum="F1A3CF94E2467CBE" modified="2018-12-05" version="1">MSKKNNQDKLLIFALGGVGEIGKNMYCIQYANDIVVVDAGLKFPEEEMLGIDVVIPDITYLTDNRDKVRGILLTHGHEDHIGGLPYVLKHLNVPVYGTKLTLGLVENKLKEAGLLGDTKRHLITADSTLTLGTIQASFFRTNHSIPDSVGICLETPEGIVVHTGDFKFDHTPVNEQYADLQRMAEIGSRGVLALLSDSTNAERAGFTPSESNIGKEFEEIFRSSKQRVVVATFASNVHRIQQVINAALETRRKMTVIGRSMVNVVSIASELGYLNIPEGMLIEPEEVNKLPADRVVILSTGSQGEPMSALTRMARSTHRKVDILPGDTVVIAATPIPGNEKYVGRTVDELMRLGASVIYGPGSISGVHVSGHGSQEELKLMLNLMRPQYFIPIHGEYRMLRHHGLLGESVGIDKENIFLIDNGDVVEFQGGTARKAGKVPAGNVLIDGLGVGDVGNIVLRDRKLLSQDGILVVVVTLSKQDGTILSGPDIISRGFVYVRESEGLLEEANRIVSSTLHKLMNDKVNEWASLKTNVKEALGRFLYEQTRRRPMILPIIMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ18</accession>
    <name>A0A398CQ18_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_06670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04290">
        <property type="protein sequence ID" value="RIE04290"/>
        <property type="gene ID" value="D3H35_06670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016667">
        <property type="entry name" value="Caps_polysacc_synth_CpsB/CapC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39181">
        <property type="entry name" value="PTHR39181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19567">
        <property type="entry name" value="CpsB_CapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="143" mass="16198" checksum="8C718C5C4A4C7D4C" modified="2018-12-05" version="1">MLELLHELAILGLRPVIAHPERNGDVLKEPKRLAEMIECGAFSQVTTHSLLGAFGAKIEKCAWDLCKKGLIHLVSSDAHHVTRRGFELRESYRVIGEKLGAEWVDYFKLNSDQLLADGDFFGMPSLSVKSKDFLKRFNLFRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQD2</accession>
    <name>A0A398CQD2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase DbpA</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dbpA</name>
        <name evidence="11" type="ORF">D3H35_22620</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Contains an N-terminal domain that binds non-specifically to RNA and a C-terminal domain that binds specifically and tightly to hairpin 92 of 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DbpA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01194">
        <property type="protein sequence ID" value="RIE01194"/>
        <property type="gene ID" value="D3H35_22620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00965">
        <property type="entry name" value="DEAD_helicase_DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005580">
        <property type="entry name" value="DbpA/CsdA_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028619">
        <property type="entry name" value="DEAD_helicase_DbpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03880">
        <property type="entry name" value="DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="35"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="233"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in 23S rRNA binding" evidence="5">
        <location>
            <begin position="408"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE01194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="483" mass="53528" checksum="C07C30FD1BF4C172" modified="2018-12-05" version="1">MTARSFNDYKLSDDIVRALAGLGYMEATDVQDKVIPIVLEGKDIAVKSRTGSGKTAAFGIPICEKVQWEENKPQALVLTPTRELALQVSEDMTNIGRFKRIKATAVYGKEPFAKQAAQLKQKTHVVVGTPGRVLDHIGRGTIDLEKIRYLVIDEADEMLNMGFIEQVESIIQALPKDRTTLLFSATLPKDVEKLCHHYMNDPVDIEINTPNGAATSLIDHSLIAVAKDADKSKLLRDVLVVENPESAIIFGRTQEQVDLIYRQLDTIGLRCGKIHGGMDQENRFKVMNAFRRGEFRYLVATDVAARGIDIDNITHVINYDLPQDNESYVHRSGRTGRAGKEGKAISFAIPSEDKFLAGIQGYIGFEIRKRKAPSPDEVLLRQPAFEKKVMTQPTLKQDKNAQLNQGITKLYFGGGKKKKLRAVDFVGTLSNLAGMSADDIGIIAIQDLETYVDILNGKGKLVLEAMRTTTVKGKLLKVYVANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQE9</accession>
    <name>A0A398CQE9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_04535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04753">
        <property type="protein sequence ID" value="RIE04753"/>
        <property type="gene ID" value="D3H35_04535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="3">
        <location>
            <begin position="225"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="504" mass="55532" checksum="927DF0E6E3494407" modified="2018-12-05" version="1">MSQLSNQPFFSRQPYGNLTHQEQDIHRRNFVVLIAMAVTTLLILASLATSGTGETDSSTLAVLIMQPVGVLLYGTGFYLRKFIPYMGYLAIVLTAASTLSTVLMSPSLQNVFSVYYMVVMALIFMNLRILLITTIYGLGLMITILYYQLDSAQAPDEVKSTYIIYYLLICTLFFCLYTVSRQMMRKMEQSRSQTEDLLRQQKEQKEELVRGIAAVTHLMNGISKAGEETSSSFEEMNSAFQEIAEGSNVQADSTSSINDSIYQLNQLVKEMTASIATLLDQTQGAARLSGEGRQKMHELSETTAEFKREMDGMSVEIQQLIERIGETGKFSDTIQEIANQTNLLSLNASIEAARAGEQGKGFAVVASEIRKLADMTARSAEQISEHLNQFMLQTNSTKQKIATVARSMQKSNEITEETLVAFDSISNAVETLRELSVGQDELMSHVNGSAGHIGDSTSHLASVSQQASATLEQLSATLQSLFETNRSSLASIKQAESNLMAIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQN2</accession>
    <name>A0A398CQN2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LemA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_13055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LemA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01731">
        <property type="protein sequence ID" value="RIE01731"/>
        <property type="gene ID" value="D3H35_13055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007156">
        <property type="entry name" value="MamQ_LemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34478">
        <property type="entry name" value="PTHR34478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04011">
        <property type="entry name" value="LemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="182" mass="21129" checksum="3E70DECF8B639E76" modified="2018-12-05" version="1">MGIYIGAAVAAILLLWIVFTYNRLIMLRNRVRNNWSQVEIVLKNRFDLIPNLVDTVSGYTTYERETLTRMTEMRTKYSSAQSINEKAQANGEVSGLLNRLMVVAENYPDLKASENFLYLKEQLTEIEDKIRFARQFYNDTVEAFNTAIMSFPSNLLAGMFGFREQTFFHIDEAEKAIPRIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQN6</accession>
    <name>A0A398CQN6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_05215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04865">
        <property type="protein sequence ID" value="RIE04865"/>
        <property type="gene ID" value="D3H35_05215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="278" mass="29939" checksum="9FBB1944E5088B97" modified="2018-12-05" version="1">MNERVNVKTLFDLTGKVALVTGGSNLGYDAAEALAELGATVAVTRRRKEEADATAALLAKDTGSEVVGIELEVTDEASWKRAVDELIGRYSKIDILVNNAGGRQVSVVPETIEDDPSFEFLETRLLEDWKYTMDANLTSVFLGCRSVAPYMKKAHSGKIINMASIDGIVGRDLRIYPGSGLSPTVPDYLASKAGVINLTKGIGVSLAPFGIYVNAISPGGFYRQQPERFVENYTKLVPLGRMGRDRIDLKGSIAYLASGASDYTVGHNLVIDGGLTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRA7</accession>
    <name>A0A398CRA7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_16720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02357">
        <property type="protein sequence ID" value="RIE02357"/>
        <property type="gene ID" value="D3H35_16720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="72"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="278" mass="30995" checksum="4ABF2FB08AFC5171" modified="2018-12-05" version="1">MNGYRAKQKLGQAVSYLLLILLAIFTLYPAIWIVTSSFREGTSLYSETMFPEKWTVIHYKELFTKFKFGEWYVNSLKVSLITMVLTVFFQLLSGYAFSRFRFKSRKTIMSGLFIVGLFPSFLSLTAVYVLLLTVDMLNTHSALIIVSSAGAAVGYLLVKGYFDTIPKSLEEAAIIDGASNWGVFFRILLPLSRPLIVYLAVTSFASIFSEFIFAQTILRTENKQTLAVGLYNMVNTQQSTQFTVFAAGSVLVAIPVVALFIAFQRMLVEGLTSGADKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRD9</accession>
    <name>A0A398CRD9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">atpB</name>
        <name evidence="13" type="ORF">D3H35_14580</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cell membrane</location>
            <topology evidence="11 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01991">
        <property type="protein sequence ID" value="RIE01991"/>
        <property type="gene ID" value="D3H35_14580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045082">
        <property type="entry name" value="ATP_syn_F0_a_bact/chloroplast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42823">
        <property type="entry name" value="PTHR42823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE01991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="254" mass="28043" checksum="0FA150D5CCDCEF3E" modified="2018-12-05" version="1">MEHLAPIIDLGGFRLDLAALLMIVISSVVVFILARVCVSKLSVDNPGKMQNFLEWVVEFVQSIIGMATDYKRGKVYLGLGLTLIMYIFVSNMLGLPFGIVTEPAHGAHSASIFGFDLPSAAEGEHAAYSWWKSPTADAAMTMALSLAVIVLSHIQGLRHNRKHYLKHYFEPWPFFFPINLIETIAKPLTLGLRLYGNIYAGEVMIGVILGMGWVGIPALLVWQGFSIFVGAIQAFVFTMLTMVYIGQASIHEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRF0</accession>
    <name>A0A398CRF0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04730">
        <property type="protein sequence ID" value="RIE04730"/>
        <property type="gene ID" value="D3H35_04400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="294" mass="33223" checksum="17A1664C55FBA16D" modified="2018-12-05" version="1">MSSFLDSIKEDPKDVLLFNESADLDGDGIEERVVAFGQSDDIKDPDINDSYINQIYMISEQNGKFERLGGNLAGETYYSYSIDIVRLQDSPQKYVYTRVTNGASLSGFILYELKELQPEVIEASSSATGVGGDELIDSDDDGRYDSFIQMRDSYDVLYYPVTRSFIWKQGKFVYEGASVALPDYPTAVREIITQYIGLKLIDAANSPEREERLKELCINESAVKAEFTWNDWSLPATVLGFEDSEDFKIDIEEQADSARAIVTISADSGNKHEYKFQLKKTENKWRIVSISDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRF4</accession>
    <name>A0A398CRF4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_01880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05145">
        <property type="protein sequence ID" value="RIE05145"/>
        <property type="gene ID" value="D3H35_01880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017318657" evidence="3">
        <location>
            <begin position="36"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="165" mass="18144" checksum="C9833851F21C6346" modified="2018-12-05" version="1">MATISVARLGLPMSCKWKCFCCSCCLKCSAKRSAAAKLHRSDANVDRRSDYRRCRNPRGLVSPSIVVVGAITAVSGVTLVNQSLSTIISILRLFFFAMGAFLGMFGIILGMIVLAAYLSRFNRSGCIYYYLKKKAFFYQECLGAISLPNSTRCCVFICDRALANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRF6</accession>
    <name>A0A398CRF6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01494">
        <property type="protein sequence ID" value="RIE01494"/>
        <property type="gene ID" value="D3H35_24380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="231" mass="24679" checksum="149E6F67F8707CEB" modified="2018-12-05" version="1">MTLSIPKGFLKFSGWALLIGGLLGVIGQLIHSGSDTPESLEVIPAFLDKAVNIHVLLAWSSIFILMGMPAMYLRQAGKLKWWGWIGFPLLFVGMILEIFHGPVQIMAYPIIYSDLATNAETLAIVNKHVNELMTDQYPLSLLVLIPLMPGLFLGLLLTGIGTLRAGAMPKAAGWFTIGIFALLVAGMFLPASIPFFAAIHLVFVLFGALLAFGGNFASLDADSSASTSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRQ5</accession>
    <name>A0A398CRQ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DJ-1/PfpI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05242">
        <property type="protein sequence ID" value="RIE05242"/>
        <property type="gene ID" value="D3H35_01600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="4"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="335" mass="35296" checksum="20A0AFECD39B5B6E" modified="2018-12-05" version="1">MLNVQIVLFDGFDLMDALAPYEVFCAAGIFAEGSIDVQLVTAEGPRSVPSGINGLIIEAGGSLNPERPGIILVPGASGEVHGDGPRSVPTILTRAMNTELTDMMKQALGHKDVTVATVCGGSLVLAMGGLLEGRPVVTNAMGMGLLCATGAIPVSARVVEDGNLVSGGGVTSGLDVALHLVERKLGPRIAHAIEGLFEYEKRGTVWRESGMAPSAPSAIDEAQDITSDARRRDVVSDFNGEWDTIIATPVGKLSVKLEIAARNGEMIEGMATQGGERSAFLNPKFEDHVLRWQQRITKPMRLNLTFEVSVSGDRMIGIAKAGILPSSKLTGTRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRS6</accession>
    <name>A0A398CRS6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03498">
        <property type="protein sequence ID" value="RIE03498"/>
        <property type="gene ID" value="D3H35_12685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="179" mass="21328" checksum="F92B4B28C7D127A2" modified="2018-12-05" version="1">MNFPWERYSHVEVRTQYEDPEHRISQDSFVLSKETVTEASWKMFVMDSGKTRFRYKIIYRAVDFRDVELPWMETDEERLTIRDPFPTKRTLEIVPLFDWTKVDRAFVDVSYEDPNNGVLEEQSFEFNDKSVATGRFVVALQDANRRQVGFKATIIRKDGTLSEVPQSYTLERRLTVRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRZ5</accession>
    <name>A0A398CRZ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type III-B CRISPR module RAMP protein Cmr4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cmr4</name>
        <name evidence="2" type="ORF">D3H35_00895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05375">
        <property type="protein sequence ID" value="RIE05375"/>
        <property type="gene ID" value="D3H35_00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013410">
        <property type="entry name" value="CRISPR-assoc_RAMP_Cmr4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36700">
        <property type="entry name" value="PTHR36700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02580">
        <property type="entry name" value="cas_RAMP_Cmr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="370" mass="41555" checksum="77EAA751BFB4C31F" modified="2018-12-05" version="1">MVMPGYWPIIGLCQYRIQDGAKALWIEKMALGWLFGELNPGGIAMVKNGKMYFFHCLSPVHIGAGQGIGDIELPIVRERTTEWPYVPGSSVKGVHRRYYKRLEEGNKANGITSAWTDAVFGRSGDKDMDDSNGIDEGNAGALVFTDSRILAFPVASVQGVFAYVTSPMALRRIVQDSKAIDLDMPDPGISQLQEVLDKDPKAAFKCPRSKLVVPGGEANDKEIWLDEFQFEAQYDLEPLAEWADWAAWQLFPEREMEIERSNWIRRLVVVSDEAFHYFVTMCCEITPRIRLKQETKTVEKGALWKEEYIPSEAILYGLVWCDKVYASGTELSPDEVLRNLHGNVPLQLGANVSVGKGRVRYLLTGEAAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS76</accession>
    <name>A0A398CS76_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05060">
        <property type="protein sequence ID" value="RIE05060"/>
        <property type="gene ID" value="D3H35_02715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017443895" evidence="1">
        <location>
            <begin position="32"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="618" mass="70605" checksum="5E396B99FB425F66" modified="2018-12-05" version="1">MTRSKLVKSILIVCVIIATLCVGIVTLNSKDDTAQSFTPIYQLGNFDKSLISQSEIRKLLKKTYYSGKDVSGFSSIPLYSAPNLYNMYWVLSLNKKLGNDIRDFKDLKELQKISGEFPLSNPNYIELDNLRMITGVYNYLGSPGNNETQIKKIISEHFDNESNLYFWKNKDESMEDKISATNVVLSILNNMNSLSTVKEVSSVKGQLIKLFNNDNYFTNDDINNTIINNGGPIIISLMLLGVTPDEDSIKAVYKKRIDWINYWNSFERKNDFYSLMVLNQLIKINTFFKLQLSVENSYVTSYFGDNGSFEGMGYESINSTEKESLNIEPQYVDMLLNICQSTHFEFPFKKELLQYVNDSIEVSFVKNGDVDITMDDNYYGLKIANSFGFPHDKAKVLQLLNSWVIKNVEEDSNIHDSYKLQQILYVLLSYKELEESFPSTATIENSVVDYLNRLEYKTYPELVETISEYKTGLEILRLLDSKIPKTTKQKIKSILSDEKDNKQLFDNIIVTDISEIIGLLNDNNLSKLLNQKITSSLGNLRFKGGYKQRVGPLGEPDVYSTAKALKSKKVEISEKDKIEINSFVLTLKSDHNEFKLSQTGSTGDLKAIFELLQISSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSC1</accession>
    <name>A0A398CSC1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_13725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01844">
        <property type="protein sequence ID" value="RIE01844"/>
        <property type="gene ID" value="D3H35_13725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="169"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="271" mass="31294" checksum="41538CEFFA704196" modified="2018-12-05" version="1">MHMQMKLPQLELHRIDEQFDNVPHVHDHHFQVTVPVRGACYFNRENKEYVLNAGESLVLNPSDRHSFRIGPDSGVIIIKVDERSFYPAHLTERVEPAFRHSVDASEFAKQFRKWTTDVFALDQVDPMAAEETESKVLSYLQRMLWADQTDILRGSGTRVNTAQTDRGMARVLEYVHAHYAERLNLDEMAAVAMQSRFYFIRSFKALTGCTPYQYVLRLRVEDAQQRLRRTADTVTDISFALGFSSASQFYRVFAGIVGMSPEKYRSYAKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSD5</accession>
    <name>A0A398CSD5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase_S8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_03060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05120">
        <property type="protein sequence ID" value="RIE05120"/>
        <property type="gene ID" value="D3H35_03060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07477">
        <property type="entry name" value="Peptidases_S8_Subtilisin_subset"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013688">
        <property type="entry name" value="GBS_Bsp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034202">
        <property type="entry name" value="Subtilisin_Carlsberg-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08481">
        <property type="entry name" value="GBS_Bsp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017451267" description="Peptidase_S8 domain-containing protein" evidence="8">
        <location>
            <begin position="34"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="9">
        <location>
            <begin position="148"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE05120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1740" mass="185091" checksum="1767F482DF8317C9" modified="2018-12-05" version="1">MGWLGSIVNFKKKGIILTLAALLFSTVAPNAGAAKNESGAPKNYIIGLKKEASSDQFVARKGLKNKKAKKAKRSNTLALSMSPEELSKVSNDADVLYVEADSAVNIASVGALNKKDASVKKVNKKAETVPWGIHAIGAELAAEQKINGNGIKVAVMDTGIAKHSDLKIAGGVSFVPDHPSYLDDNGHGTHVSGTIAALDNRIGVVGAASKVSLYAVKVLDGTGEGSYSQVIQGIEWAIDNKMDIISMSFGGTEDSQALHEAIKAAADQGILVIAAAGNSGAGEETELYPARYSEAVSVAAVNDKYQRASFSSTGSQLDLAAPGTDILSTTSDGEYGVLSGTSMATPHVTGAAALLWSKNKNWSPEQVKQQLYDTATPLGNVHEYGRGLVNVAKALQLIDGPVEPIDSNPSQEPSVPDNADGDTFNVNALDLRLLELSDQLDALKRKAQAAGNIDLAKQLQNQYYSLHKQSAQLHGAAAPSAADSKPTTKTKAESASKALTIKNELKAKADEFKALEDSYKKAIADGTAALTLPGAGASGQTVTGAVYRSGDGQIVPAGQPVTVYVSWPQPRSKIFVTVTNIETKAIVASDTSYPTELTASYTWNTSASTVPGSYSIRLAYPEAPEQSDEFTILVNAPEPVSSDTETEALTAQSSSVTIQAVKTLTLNTAVDVNLAAGVTQVYSFTPSVTDKYRLMTSPYGGTGAASDTVLDLYSDANLTNMIDWNDDGANAPFSQIDVVLTGGVKVYLVLSGYGGGDVHARLLAKVFAPTIAVSGTVDVNSPQDEFVPYKFTASSSGFYRFFTTYYGGTSSGGLNDTMLNVYSDMDFLYLEDYNDDAYTGNTFSEVSLYMTAGTTYYMQVGSPYSNLRARLSVAAVSVPALSLTSSIDADYSTGVLKVYSFTPSSTGMYKFYTGAYGGTGADNDTRLELYDDARLTSMIAWNDDNGYFSTNFSEIAISLTAGVKVYLKVTGSYYGDPLRARLKVSAYPPTVSSGSYVDGDSRTGGSQIYKLTAPSSGGMYKVSTGYYGGTSSGGINDTMLEIFSDVDLNNLIDYNDNVGNSLFSELIVPVVGGQSVYLKVSEVNGNVVHARLSVATLSVTTLSLNTSVDVAPSTGSIKLFKFTPSSTGTYRFNTTYYGGNSNNPVSDTMLTVSTDQAFQNVLPYGENDDANGTYFSEANVYLTSGVTYYVKLINIDSTPLNTRIKVSSLLSAKGAMEKPTSGQTVNGTFEVSGWALDGLGVDRVELLVDGIVKATAVYGYNREDIYTANTTYNNHDAGWMAWFDSAVLTNGTHTLSARSVSYIDVKTTLTTRTITVSNTRNATILSDTIPTNMEAGKSYNVAITVRNDSTVTWEAGTGFSLGAVGDSDPFAAIRQQIPAGQAISPGQQYTFNFVMTAPTGAGSMGSKTTDWQMRQDNFGWFGAILTKTVTVVDINYPSASSISNPGLVAASSGSYEVFAYGVTDTGTGVANVEFVTWTEAGGQDDIVSHAGTNMGNGTWKAAVPINQHKNERGNYITHVYATNITGNRVFVGNATAKVYSDSGKDYSYDTSGRLMSINYPTGNAIRYLYDRNGNLLQRKWYDPTNNTTALSDFSQTQGYKNWSYAEWNGTSYIPLTWELKTGKWVNNTSKTEIKSQSQLPGTTDAVRKWVASVPGTITIAGNVAKGDVGGGDGVRVKIMKNGTQIWPAVGWREIAYDNAYGYNIDMMTSVAAGDAIYFVVNSNATSANDSTNWNPSITYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSM3</accession>
    <name>A0A398CSM3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_14375</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01954">
        <property type="protein sequence ID" value="RIE01954"/>
        <property type="gene ID" value="D3H35_14375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="18"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="273" mass="31334" checksum="9D3550DA60882B1A" modified="2018-12-05" version="1">MIDRIDGRIAEWSSDAPIGLGVWRTPEGEQTEEAVTAALNAGYRSIDTASLYENEGGVGRAIRESGIAREEIFVTTKVWNNEQGYDNTLNAFRNSLERLQMDYVDLYLVHWPVAGKYLETYKAIEHLYEQGKVRAIGVSNFLIHHLEDLMGSCRIKPMVNQVEFHPLLTSKKLLMFCRKEGIQLESWRPLMQGRLDIPLIRELASKYGKTPAQIVLRWHLQQGVVTIPKSVRKERIEENADLYDFELAPEDIVRIDGLNEDRRFGADPDRVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT40</accession>
    <name>A0A398CT40_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03928">
        <property type="protein sequence ID" value="RIE03928"/>
        <property type="gene ID" value="D3H35_08160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="137" mass="15380" checksum="9E3176B7E2B0BE7B" modified="2018-12-05" version="1">MANKSISVPADIKAFLDGLPNASSYVVDLINRDRGSGDANLENSIRKVLTELLSELKPPPVQSDPQWHVLESRACLELTLAADDPSDLVDPRVLAEIDRLAGREDYLTRVRMDGVMTFGQNELARRTLYYERNEPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT63</accession>
    <name>A0A398CT63_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_00735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05350">
        <property type="protein sequence ID" value="RIE05350"/>
        <property type="gene ID" value="D3H35_00735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="15"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="355"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="415"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="486"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="545" mass="57326" checksum="89C96B94C51399AB" modified="2018-12-05" version="1">MSAESNEASATPAAIPAAPTNVSAVAGDGRATITFTAPTDIGGSAITGYEVTASSGNVVLRGTASPITVTGLNNGTSYTFTVKAINSVGSSAPSAESNAVVPKSSSNGGNNNGNTPSEQETSTPPQTGNTGMDVLVNGKVEKIGAATTSEVNNQTVTTVAIDQKKLEDKLAAAGQGARVTIPVNAKSDVVIGELNGQSVKNMEEKQATLEIKTDNATYTLPAQQINIDSLSEQFGKSVALQEIKIQIEIAKPTADTLKIVENAAAKGTFTIIASPIEFTVRASYNRTTIEVSKFNAYVERTIAIPDGVDPNKITTGIVVDPDGTVRHVPTKVVVIDGKFYAKISSLTNSTYSIVWHPLEFSDVSNHWAKNAVNDMGSRMVISGIGNDRFSPDRDITRAEFAAIIVQGLGLKLEKGESAFSDVQASDWHSSAIKTAYAYRLINGFEDGTFRPNDKITREQAMVIIAKAMTITNLKAKLSAPLIDSTLRSFADAAEASSWAQSSIADCVQTGIISGRSSTELAPKNYITRAEVAASVAQLLKKSELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTH6</accession>
    <name>A0A398CTH6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_16160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02264">
        <property type="protein sequence ID" value="RIE02264"/>
        <property type="gene ID" value="D3H35_16160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="287" mass="32396" checksum="8EEBD1CF74524FE4" modified="2018-12-05" version="1">MKARYVYLATAALVVAGWLGNYFFYRSGQLPEGAFLRHYIETADLPGATFNLFYAANNRDKRKIVDVRIEELPGLRFYPPSTRASLRHQTIYSLIGHFDIPSSEQDRREDGEPLKIRSVDVRFNDGTMRREEIGEIIVYREKYLQEAGDEAPFEFTSSKGSTDHSGSNSGHATRPAVLTGVTSSWLKRLGPALRIEIKTAGEPTFRPADAGVPLKLDAGDTLSIQYRFDLSASPEVNAMDVYNVLLRPKFKEADGRQSEKIIFANYDPYPTEAEMRSFVRAKREEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU34</accession>
    <name>A0A398CU34_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_11855</name>
        <name evidence="7" type="ORF">D3H35_21910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01081">
        <property type="protein sequence ID" value="RIE01081"/>
        <property type="gene ID" value="D3H35_21910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03367">
        <property type="protein sequence ID" value="RIE03367"/>
        <property type="gene ID" value="D3H35_11855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="396" mass="46203" checksum="5F1C72F993AAF971" modified="2018-12-05" version="1">MTTIPENMLNDLFENLVTQFVKQNIETIMRAEIKHMLEEQEEHQRNSRNGYYTRTLHTKYGHIEDLQVPRDRNGQFQTSVFEPYQRRDGWLEEAVIQMYKSGMGTRDVARFIESMFGSQYSPTTVSNITATVLEDIQIWLQRPLKKRYSVIYLDGLYVKLKRGTVSGEVVYFAMGIDEDGHRQILGFYIGGQESSNGWREVLKDLYKRGATDVLLGVFDGLTGLEAAFRETYPKADVQHCVVHKVRATFPKIRVQHRTEVIEDIKTVYTAEDKDLALAAFDTVYAKWGKLYPKEMELWKEQLPTLLTFYKFPSLIKEAIYTSNPIERMNKEIRKRLKPMNSLTNMDAAEKIVYLQAIDYNERNESRAIRGFADPEVKKKLTEMFEARYSDKITSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUD1</accession>
    <name>A0A398CUD1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_12420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03457">
        <property type="protein sequence ID" value="RIE03457"/>
        <property type="gene ID" value="D3H35_12420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="24"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="159"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="277" mass="30395" checksum="094D2C4BCFD81354" modified="2018-12-05" version="1">MSYVKDYTNGHLLADVNEVERYSLKEGAIIIDARTKGFEDGHIPGAVSLPSALTKSKDGIGIVPADLFTELAQSAGINANTTVIVYDEGDSVQATRLFYALEYYGHADKVKVLNGGLAIWLRAGKPLSVEETWQARGNFSATPHPERFTGKNQLQRELNDTSIVALDTRAIDEYRGDNLRNNARGGHIPGAVHLEWKDAVDRTVPEAPIFKSGAVLTEQFESAGVLKEKTVVPYCQSNGRGAHTYFALRLLGYPNVRPYEGSWAEWGNSEDTEISLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUJ8</accession>
    <name>A0A398CUJ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_06840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04318">
        <property type="protein sequence ID" value="RIE04318"/>
        <property type="gene ID" value="D3H35_06840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="537"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="815"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="861"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="921"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="330"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="848"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="589"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="955" mass="105435" checksum="E76F74FF5546F680" modified="2018-12-05" version="1">MAALIRFLFRKMWNTRWLTLSMLAGLLVAVAFTTSIPMYADGALKRVIAQSLQDNDTGLPAGSLLIRYQSTDGKTDMNRFKSVDEYIQGDVADKIGFPATASQRTLTIRSTEISPEDPTKIDASRTRKMSISALSGLKDQAELVKGSWYDDRAGSDGTLKALMMEEAMFRNDLHVGDVLLYPIYGGLDLMLRVEIVGAFKPAAEGGAYWYQGLESLMNTLFIAEPAMIQDLAEKQSIPFQSASWYTAYDLREIKTSQLAPLAGSFKRIDLDVYQKLKDTHLDISFADMLNDFRRDSIQLQTMLFTLAAPMIAMVFYFITMLSRQALEKQRSDIAVLRSRGASTRQVFLLFLLEGILLGVFSLLTGPFIGWFMAKSIGSANGFLEFVNRKAIPVGFSSDGVLAGVAAVLVAIGAAVIPALVFTRTSIVDYKRKMARKEQKPFWQKWFLDVILAGVAGYGWYLFNERQMVTFKTGMTTDQLNVQPFLFFVPALTIFAVGLIFLRLFPLLLKLMNWLWKKLLPVPLYLTLTQLSRSASSYYPLMILLILTLGLGVYNSSAARTIGQNSEERIMYKYGSDVVVTPVWEATPEATPITGGNNGGGSGGGSGGGSGGGGGGQRPPTPSKLIYNEPPFELFRTLPGVEHAARVLQTKSSITVSGKSAGQGMVVGIDNVDIARVAWFRKDMYPISPYKYLAWLGKVPEGAIVSSNMAKKFNMKPGDIIDAIIQEKKVQFAVIGIIPYWPGQYPDQLPFIVANLDYIFDEAPKVPYDIWLKMEPGALTAPMLPVLQSKGIELATFGDMRSELVTQSKHPARGGIFGILSLGFMVTIVVSLSGYVLYWFFNLSGRIVQIGILRAMGLSRKQLTGMLLLEQVFTAGLSIALGIGIGKLTSILFLPFLQTTENAVNQVPPFRVVFEQADTNRLYIVVAVMMSIGITLLITHIRRLRVHQAVKLGEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUY4</accession>
    <name>A0A398CUY4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02824">
        <property type="protein sequence ID" value="RIE02824"/>
        <property type="gene ID" value="D3H35_19520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="310" mass="34594" checksum="969E3460F4A2AC6A" modified="2018-12-05" version="1">MRILITGATGFIGAAIAHRMAALDLEVHIFTRPSSNRWRIESIAPKLIEHHVDLEDEDAVVRAVTGIRPEYVFHAACYGGFSFQQHVKRAFLSNLFGTMHLLGACERTGFEAFVHFGSSSEYGVKDTPMSENVLLEPIGAYSVSKAAATLYCRSRAVETGLPVVTLRLFSPYGPFDDPQRLIPYVVSKLLRRQTPSVLTPSSVRDYIYIEDVLDICEIMLAGPVPSGEIVNLGSGVQYSIGEVVSILYQIIGVESQPSWGSLAPRRTESAIWTADTTRMKRLFLWEPMYDLETGLESTVEWIHSRMNDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUY5</accession>
    <name>A0A398CUY5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_02815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05079">
        <property type="protein sequence ID" value="RIE05079"/>
        <property type="gene ID" value="D3H35_02815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="404" mass="45492" checksum="E28188BB8CDD5C8B" modified="2018-12-05" version="1">MGRGTFERWSIDIVGSIVALQQGSGPVYDDGASAPDGSIPVQDGLLKADDRCAMDWEYDRLTTATGMKYYAYPYADWWRTELIRHLISITLSKGKLLPFLSFWPAGIPAVAVISHDSDINKDEHAAATLQLLREVDARSTWCMLEPGYSSATYDEVKADGHDLCLHYNALDMEGGKWDEEAFRNQSKWLRDAAGIDRISSNKNHYTRFEGWGELYRWCEQNGIESDQTRGPSKKGNIGLIFGTCHPYFPVSDFMEGNRSYDVLEIGFLSQDLNHPELYDSSLVDPFLNIVRESEGVAHFLFHQVHIYNFEPVRQAVREVVAGARQRGFALWTVDEVNQWERARRSVSIAGVDESGRPVLEGEELPQATVVYVPVSADSSATDGDCEIKFGFVCRKYTICERNDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVD5</accession>
    <name>A0A398CVD5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Diacylglycerol kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_06195</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial diacylglycerol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04478">
        <property type="protein sequence ID" value="RIE04478"/>
        <property type="gene ID" value="D3H35_06195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14265">
        <property type="entry name" value="UDPK_IM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000829">
        <property type="entry name" value="DAGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036945">
        <property type="entry name" value="DAGK_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033717">
        <property type="entry name" value="UDPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34299">
        <property type="entry name" value="PTHR34299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01219">
        <property type="entry name" value="DAGK_prokar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE04478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="97" mass="10323" checksum="C578848281E35AAC" modified="2018-12-05" version="1">MRFHLFAAALVIVMALLLDIDKNGWLWLIASIVGVLTSEMFNSAIERAVDLATAERHPVAKAAKDIAAGAVLVASLGAAAIGLIVLGPPLWHWLAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWB1</accession>
    <name>A0A398CWB1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03501">
        <property type="protein sequence ID" value="RIE03501"/>
        <property type="gene ID" value="D3H35_12700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="166" mass="17703" checksum="E0B7EEFA8C8714BC" modified="2018-12-05" version="1">MPVPERDPSGQAVLTLWLFGQNQSSRLQFGVQWTAEQSTLQALAAEIVRRYPERKLTAASIRLMPAQVDIDSVTLAIGDGSGTFADLQSVRSSGYPPFSALFNTALTSEQSGQATAALNGSPDRLTVTYRGQVQRSGQGAAQLAATADLSRWLPAGTSANYIRSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWB7</accession>
    <name>A0A398CWB7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosine recombinase XerS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">xerS</name>
        <name evidence="6" type="ORF">D3H35_05115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04848">
        <property type="protein sequence ID" value="RIE04848"/>
        <property type="gene ID" value="D3H35_05115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="17"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="149"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="357" mass="41950" checksum="683B74674C69BAB8" modified="2018-12-05" version="1">MNIQKIKDREELDRHIPLMPWYVEKFVNFKLPDLSPSSLLEYVRDYETFFKWLMSEALTKAEKMSAIPLEDLEKLHMESVDNFRMFLATKREYANGKTTISRKLSSLRSLFHYLSQIAEDDDFYPLLKRNVMAKVTIKRTHKPKDTAAKLEGKLLQEQEILEFIAYIKQDYGHDVATNKQALYSHELNRIRDCCIVSLVLNSGLRVSELVNLNTDDLDMKKQLLYVYRKGKNDDAFKTPVYFRNDAIEDLLLYMGQRDTRYKAPKREKALFLAIANGKKEGSRMTKRAIQEMVIKYAKRFGKPYLSVHKLRHSFATDYYLRNDLYKTQEQLGHASPETTQIYAHLTDKTMAEAIDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWC7</accession>
    <name>A0A398CWC7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bifunctional metallophosphatase/5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_08265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04127">
        <property type="protein sequence ID" value="RIE04127"/>
        <property type="gene ID" value="D3H35_08265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="2"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="3">
        <location>
            <begin position="273"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="470" mass="52007" checksum="C814552AC93168B8" modified="2018-12-05" version="1">MLHTNDLHSHLEQTARIAAYIKSVRSKSDPSSLLVVDCGDFLDRARPETEGTDGAVNRRLMETIGYDAVVLGNNEGLTYTYEQLDRYYSPLTAPVVCANFKSHDPEASLSWLVPSLTVRRSGLKIGLIGLTAAFGAYYDHLGWKASDPLEALRQWTVKLRPEVDVLIVLSHVGLKMDETIAQSIDGIDLILGGHTHHLLESPLRVRNTVLCAAGKFGTHIGHLHIAKDEQTGKINITGGCLSMDDRETDKEAEAVIAAGREQAARRMSRVVARLEEVLPQSLHEESRLPTLLATAIRHRTGAEIGLVNSGQMLGDLPEGDVTEAVVHAICPSPINPCTLRLTGEELLLTLEESLQISFRELEIRGFGFRGKWLGGLCLDGMEVDADLSLPEGSRITGARVNGERLVKEREYIVGTLDMFTFGVGYVRLKNGREPSYFLPEFIRDVLSEALRNKEWIEGSRVRRWNVTNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWL6</accession>
    <name>A0A398CWL6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03414">
        <property type="protein sequence ID" value="RIE03414"/>
        <property type="gene ID" value="D3H35_12165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="34"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="175" mass="20611" checksum="06CEEC133D7351A7" modified="2018-12-05" version="1">MDAIRFPIGQFEAIVNLTNEERIAITEQIPEITKKLRETISKLKPEQLDVPYRQDGWTIKQIVHHLADNDMNAYLRFKKALTEDEPMGQSYREDLWAELSDYGQVPVENSIVLMETLHLRFMILIHALKPEDFQRKLRTQVLGSVTLDVALQRFVWHHRHHFAQIESLIGRKAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXI4</accession>
    <name>A0A398CXI4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_10370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03694">
        <property type="protein sequence ID" value="RIE03694"/>
        <property type="gene ID" value="D3H35_10370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="81"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="311" mass="34599" checksum="64DAA32F96FA5F8F" modified="2018-12-05" version="1">MKPLAKIGRGVSRFWLSQSPLYMMLLPGMLLLFLFSYMPMFGLVMAFTDFKPRLGFFGSPYVGLKWFDYLFNSSPDFSQVLTNTIVISLLKIAFGTAASLVFALLLNEAVVKWFKSAVQTITYLPNFLSWVVVGGMFIDILSQDGIINRILHAFGSPGVFFLGSNHWFRSVIVATDVWKNFGFGAVLYIAAIASINRDLYEACVVDGGGRFQQMRHVTLPGIMPTLIMLTTLNLGQIMNAMNGGQDQILVLYNPSVYETGDILDTFAYRTGIIDVQYSFATAVGLFKSVVGLVLIVSANRLSIKYASRRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXP8</accession>
    <name>A0A398CXP8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000012">
        <property type="protein sequence ID" value="RIE05308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05308">
        <property type="protein sequence ID" value="RIE05308"/>
        <property type="gene ID" value="D3H35_01285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="86" mass="9724" checksum="112D43B07B02A6A3" modified="2018-12-05" version="1">MLKNSKIKEHLPSKRFTSFLEWNLRFKWLPILIAFLLLLGSVGTYFSLPKGAIDNSSASSLSITLDYKPDTPVDEVRKTDSSSKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXR0</accession>
    <name>A0A398CXR0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_05685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04577">
        <property type="protein sequence ID" value="RIE04577"/>
        <property type="gene ID" value="D3H35_05685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="251" mass="26384" checksum="183655AE9373E30E" modified="2018-12-05" version="1">MIRNPMASPDVLGVTGGASSAAVCFLSYFAGTVSIRFLPVAAMLGAAIVTVALYSLAWKRGVTPLRLVLVGVGLSAILSGITTMMVLFNPRNEADQAYVWLTGSVYGANWENVLTILPWTVILLPLAFAYARHIDIVQLGDETATGSGSRVQFNRFLLLCVSVGLAGSAVSVAGGLSFVGLIAPHMARKLMGPSFGKMFPVSVLLGAIVVVLADLAGRMLFQPLDVPAGVFTAGVGAPFFIYLLYSKRNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY67</accession>
    <name>A0A398CY67_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_04440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04737">
        <property type="protein sequence ID" value="RIE04737"/>
        <property type="gene ID" value="D3H35_04440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="202" mass="22935" checksum="63A36475226A16FA" modified="2018-12-05" version="1">MSPRNADRDRLLREERREQLREAALEVIARRGLSAAKVADIASSAGVSVGYVYKYFESKEQLFMELVEEGQLRYREFVAEVRARSGSALERMRWYTQQWLGKKEWAITILLQYARTSEAVPEHFKLEVSRRFLDNLKPLADIIKDGQSEGTFVAGDALELALLYVSLMEGLTLHNLPGVQEINAGTPDKALGLLLLREHDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY76</accession>
    <name>A0A398CY76_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="7 8">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murF</name>
        <name evidence="12" type="ORF">D3H35_04495</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="7 8"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04747">
        <property type="protein sequence ID" value="RIE04747"/>
        <property type="gene ID" value="D3H35_04495"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="9">
        <location>
            <begin position="28"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="11">
        <location>
            <begin position="112"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="10">
        <location>
            <begin position="321"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="114"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE04747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="477" mass="52187" checksum="65E07AEAE2B085BB" modified="2018-12-05" version="1">MIQRTIKQLTDMLIVPCPFSELEASVAISGVSIDTRTLRPGNLYVPIVGDRFNGHAFVRQAIDNGASAVLWNRNEPHAPQDVPVIRVDDTLSALQLLASTYRSQLPCTVVAITGSNGKTSTKDMLAWMLGERFKTHKTPGNLNNHLGVPLTLLQLAEDTEVAVVEMGMSGFGEIALLSSLVMPDYAIVTNIGDAHLGDLGSKDNILRAKLEIMHGLKNNGTLIYNGDDPYLSAALAGKEWPFRTRTFGMEPSNDCQGLSMVREKRGSSFFVASDPSIRLFVPLHGQHQVLNALAAVETALLLGMELHQIRNGLANVRISGMRNEVIRTDGMTIINDTYKSNPASAVAALDTLYGLQDYRQKIAVLGDMLDLGQEETSLHAHVGSFADPAQLDYLFAYGPRSASTADCARKLMPPGRVFHYSDKQEMIRDLLRHIDPNSVVLVKASRELMLEEVVAALLQSKSLDSAKKGWDFHEANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ10</accession>
    <name>A0A398CZ10_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04471">
        <property type="protein sequence ID" value="RIE04471"/>
        <property type="gene ID" value="D3H35_07775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="178" mass="19103" checksum="7722962659F6C38F" modified="2018-12-05" version="1">MGGKWSGLIAEACRYDAEGLWDIEIADGKIVNVEPSVPGRAVLAGEMLRAKGALLLPGLVETHIHLDKAFLSNRMPRPAGSVAEAIAMTAELKSSYTPEDITARSELALDRASRFGVTRLRAHVEIDPIVGLMSLESALDIRRCYADKIGIQLVAFRRKASSVVGNRSSSSRSDAIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D039</accession>
    <name>A0A398D039_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_05030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04831">
        <property type="protein sequence ID" value="RIE04831"/>
        <property type="gene ID" value="D3H35_05030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="31"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="116" mass="13237" checksum="FD2BC483DCAC3BDF" modified="2018-12-05" version="1">MDTRITTPLAVKPASSAELTLEPSIYHFGVRYGMTPRERDVLRLLILYGFKNDDMAGILHIAVKTIKNHLACMMGKTRTRSSRELQALFLRFMIQQSIEKKRVSTESRPALGEWDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0L1</accession>
    <name>A0A398D0L1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SRPBCC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04694">
        <property type="protein sequence ID" value="RIE04694"/>
        <property type="gene ID" value="D3H35_04195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="168" mass="19244" checksum="F0C67EAA300BDA7E" modified="2018-12-05" version="1">MEKRSTSESIVLRKGERDFVVERTFDAPKALVFKAFTRPEHVARWWAPGGYTIPVCKIDLRPGGLWHYCMRSPEGQDQWVRAVYREIVEPDRIVYVITFADEEGNPTEEIPEQEGTITFDDYAGKTKVSIRIMLGTAEELKWTLEMGMVEGMTETLGNLAKLLNEIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CAV8</accession>
    <name>A0A398CAV8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphodiester glycosidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_29680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00276">
        <property type="protein sequence ID" value="RIE00276"/>
        <property type="gene ID" value="D3H35_29680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014565">
        <property type="entry name" value="EpsL_firmicutes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031512">
        <property type="entry name" value="EpsL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="NAGPA" evidence="2">
        <location>
            <begin position="129"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="312" mass="34347" checksum="A79089F4BE613EB1" modified="2018-12-05" version="1">MAIFRRRKKTKITLIIVLFFAVIGTILYRLADRYLIEHVEVVVTDNRTVANTAAVTQSSGQVQSDDWNYKSDNETISVKKVQTGSGEETITYFVADVTFTNSTNLLTAFAKNSFGTNIIENTSTIASDHNAVFAINGDYYGFRNNGVIIRNGELYRDDPAREALALFNDGTLKSYDEEQTSSSSLLAQGVTNTFSFGPVLVKDAEVAGDFDSVKIDTNFGNRSIQSSNPRTGIGMISPNHFLFIVVDGRKENYSKGMTLTEFANLFAELGATEAYNLDGGGSSTMYFMGRVVNNPLGKQKERGVSDIIYIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBM1</accession>
    <name>A0A398CBM1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spore coat protein CotH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00556">
        <property type="protein sequence ID" value="RIE00556"/>
        <property type="gene ID" value="D3H35_27850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050">
        <property type="entry name" value="PTHR40050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="351" mass="40235" checksum="30E2560283BEA697" modified="2018-12-05" version="1">MALPVVHLRLNASTVAAMEKNVWSDRFATAHMLTESGQDPIRVRYRGGHTRNYPKRSYEVVRNGRIWHYNAEYDDPSMIRNALSFAFFPWLGVSAPRTQHVLLYRNGERLGVYLEIEGVDRSFFRRRNIGATALFYASSSKADFELNAPGTDKPKRTLLAGYEHRFGGLEGKELLTGFIAGLHRGTGRQLASFIRSRLDTDAYLRWLAGAVLTGNFDGFEQNYAIYRHRNSGKWRVLPWDYEGTWGRNCYGRLVEAGLVSVTGYNALTRKLWEHRPFRRAYAGILKEALDGPFTELRLMPLVDRMLGNVSAEIRKDAARRYSASEFSGEASVIRRYIRERRAIVAREAERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBX6</accession>
    <name>A0A398CBX6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Elongation factor G</fullName>
            <shortName evidence="7">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">fusA</name>
        <name evidence="9" type="ORF">D3H35_29430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000062">
        <property type="protein sequence ID" value="RIE00283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00283">
        <property type="protein sequence ID" value="RIE00283"/>
        <property type="gene ID" value="D3H35_29430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="8"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE00283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="706" mass="77815" checksum="412A80D63AFBB2B4" modified="2018-12-05" version="1">MSREFSLQNTRNIGIMAHIDAGKTTTTERILFYTGRVHKIGEVHEGAATMDWMEQEQERGITITSAATTAQWKGHRINIIDTPGHVDFTVEVERSLRVLDGAVGVFSAKEGVEPQSETVWRQADRYGVPRIAYVNKMDIIGADFLNVVKDMKERLGANAVAIQLPIGAENEFVGMIDLIERIAYVYKDDLGKEPVESEIPANLADQVEELRAELVEKVAELDEELMMKYLEGEEITVPELKAALRKGVCEVKIFPVVCGSSYRNKGVQPMLDAVVSFLPSPVDVPDIKGTLDDGTETVRKSADDQPFAALAFKIMTDPYVGKLTFFRVYSGVLNSGSYVVNATKGKRERIGRILQMHANSRQEISEVYAGDIAAAVGLKDTTTGDTLCDEKNPVILESMNFPEPVIQLAVEPKTKADQDKMGIALQKLAEEDPTFRAHTDEETGQTIIAGMGELHLEILVDRMLREFKVETNVGKPQVAYRETFKSAAKVEGKFVRQSGGRGQYGHCWVEFQPVEAGVGFSFENKVVGGAIPREYIAPIQAGIEESMKNGVLAGFPLVDIKAIVFDGSYHDVDSNEMAFKIAGSMALKAAKEKCNPVLLEPIMKVEVTVPEEYMGDVMGMLNSRRGRIEGMDTRHGAQIIRAKVPLAEMFGYSTTLRSGTQGRGVFSMELSHYEEVPKSISEEIISNTKALKRSTICKRTGRGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBZ2</accession>
    <name>A0A398CBZ2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_29340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000060">
        <property type="protein sequence ID" value="RIE00300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00300">
        <property type="protein sequence ID" value="RIE00300"/>
        <property type="gene ID" value="D3H35_29340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="152"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="241" mass="27860" checksum="11CD14C11C2CC147" modified="2018-12-05" version="1">MNRPELTAEKFVANPFAPGERMYRTGDLARWLPDGNIEYLGRIDEQVKVRGHRIELGEIETQLLKHESIRETTVLERKNKEGETYLCAYFVADKEISVMELRKHLSISLPEYMIPSHYMQLEYTPLTSNGKVDRKVLPEPDGRMTLGIVYEAPRNELEEEFVLIWQEVLHIERVGIQDNFFDIGGDSIKAIRLMSRIGTKLDQKVTIHDLYLHPTIKGFLEARSDIESSMMNANNSNLPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDP8</accession>
    <name>A0A398CDP8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spore germination protein GerPE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_26575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00760">
        <property type="protein sequence ID" value="RIE00760"/>
        <property type="gene ID" value="D3H35_26575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024496">
        <property type="entry name" value="Spore_germ_GerPE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10970">
        <property type="entry name" value="GerPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="128" mass="14337" checksum="CCE33192EE13D79A" modified="2018-12-05" version="1">MSVESRCSRADCILINSVSLASVVQFGDNCKTELRSRALAVQRAVTDFEQDEARFASYGVFFRPELRLSGCTDVRFHSRSDGSSICVRSLYTLAVSASSLIRFGSGESHRAVARIKHIRQFNDNRDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE35</accession>
    <name>A0A398CE35_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000043">
        <property type="protein sequence ID" value="RIE00890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00890">
        <property type="protein sequence ID" value="RIE00890"/>
        <property type="gene ID" value="D3H35_25895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="366" mass="41250" checksum="4A48F17F6686B0CB" modified="2018-12-05" version="1">MSRRLIELPSTLLRIEGFRSSILNNERDLRLYLPPGYSENPDSRYPVLYAHDGQNLFDKGAHETDPLNPFAVARSWNLHLTADRLIAEGLMEEVIIVGIFNMGGERSGEYMHGLEGIEHERDRDQAVPRGELYERFLVEELKPFIDSVFRTKRDAENTGLIGSSRGGQITYHIGFSRPDIFGKLGILSPYFYYVNPLTLIEYRMYVSFPSRLPLSKIWIDLGGREGVLVMEKHVRQVVAELLDAGYEPDSQLAFYFEPDAAHTEADWEERAHLPLLHLFGKPSKLAGVSLKELGTSFFERSKLRLLPTAEYENGWRITPLNGSFKSADPDAASVDHSGGIVPKEGGTAVVEYEFEGKRAKASVTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEC7</accession>
    <name>A0A398CEC7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ParB/RepB/Spo0J family partition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_24550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01526">
        <property type="protein sequence ID" value="RIE01526"/>
        <property type="gene ID" value="D3H35_24550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="410" mass="47525" checksum="91E8FCA65EDE4326" modified="2018-12-05" version="1">MKTQEPFLENEQARLLYRITKTESQKGSYNVFIQDRLKNKPVYKVPIDLLRYNDNNFRIRHQVDYKVESEGITLIDEDIEDQTWIEDILNADDPDVKRVNTFLSQSIKKYGQKDPVIVRLADAVVVDGNRRLMTLNKLVLEGNAEFKVVDAVIIDEELTDIEWLELEARYQYEKDAKSEYDNINEAKMLKKLYDIYNDYDAVAKRVQSRKSHVEMRIATLSLIDSYLEKLGSKNNYSRISSFTLFEELAKEQEKRTELTPTELHELEVTGLNVITLKSVIEESNKKSRLVNGVKEDDTIDDRIFRKMLKTFTLEPAKSVLTQTVKGDSLLSYEEIKAVKNDFKNDVSTAILIQEAHKQAKEPLRMINLAISHLKSIQNLKGNARNPIVTAIGDVTRELNRIRQMLMNEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEF6</accession>
    <name>A0A398CEF6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">clpP</name>
        <name evidence="11" type="ORF">D3H35_21390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01010">
        <property type="protein sequence ID" value="RIE01010"/>
        <property type="gene ID" value="D3H35_21390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00493">
        <property type="entry name" value="clpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE01010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="193" mass="21356" checksum="4CFC7717F9B8464B" modified="2018-12-05" version="1">MSFVPMVIEQSNRGERAYDIYSRLLKDRIIFLGTGVNDVVANSIIAQMLFLAADDPEKDIHLYINSPGGSITSGMAIYDTMQFIKPDVSTICVGMAASMGAFLLTAGAKGKRFALPNSEIMIHQPLGGAEGQASDIEIRARRILKMRDKLNKILSERTGQPIERIEKDTDRDNFMDADVAQQYGLVDKVIEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEX9</accession>
    <name>A0A398CEX9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylmuramic acid 6-phosphate etherase</fullName>
            <shortName evidence="2">MurNAc-6-P etherase</shortName>
            <ecNumber evidence="2">4.2.1.126</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">N-acetylmuramic acid 6-phosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">N-acetylmuramic acid 6-phosphate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">murQ</name>
        <name evidence="4" type="ORF">D3H35_23135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:26410"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="EC" id="4.2.1.126"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-sugar metabolism; N-acetylmuramate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.126" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01283">
        <property type="protein sequence ID" value="RIE01283"/>
        <property type="gene ID" value="D3H35_23135"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00342"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046348">
        <property type="term" value="P:amino sugar catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097173">
        <property type="term" value="P:N-acetylmuramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05007">
        <property type="entry name" value="SIS_Etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00068">
        <property type="entry name" value="MurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005488">
        <property type="entry name" value="Etherase_MurQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="PTHR10088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF5">
        <property type="entry name" value="PTHR10088:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00274">
        <property type="entry name" value="TIGR00274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="3">
        <location>
            <begin position="57"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="304" mass="32744" checksum="2DFC7362FDBDAEDA" modified="2018-12-05" version="1">MFHILDSLTTERQNEATRNIDRMSTRQMIELINGEDRLIADAVASIIPQITDAVEAIVQRLRGGGRLIYMGAGSSGRLGILDASECPPTYGTDPQTVQGIIAGGDIAIKSAVEGAEDNDELGMEDIRNLQITSADIVVGISASGRTPYVIGAMKEASTIGAAVIGISNNRGCPMGNYADYMLECDVGPEVVLGSTRMKAGTAQKMILNMLTTASMIRLGKVYDNIMVDLTPSNEKLVWRAKRTIQMATGVSDEKAEQAFEDSHRHVKKAIVMLLADVTCEEAGQLLERAEGNVRTAIESKEIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFT1</accession>
    <name>A0A398CFT1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Ornithine aminotransferase</fullName>
            <shortName evidence="8">OAT</shortName>
            <ecNumber evidence="3 8">2.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Ornithine--oxo-acid aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rocD</name>
        <name evidence="10" type="ORF">D3H35_23600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the interconversion of ornithine to glutamate semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="3 8"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01360">
        <property type="protein sequence ID" value="RIE01360"/>
        <property type="gene ID" value="D3H35_23600"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050155">
        <property type="term" value="F:ornithine(lysine) transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine-oxo-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01689">
        <property type="entry name" value="Ornith_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034757">
        <property type="entry name" value="Ornith_aminotrans_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="PTHR11986:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="6 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE01360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="399" mass="43788" checksum="F95F7B0FBB23578B" modified="2018-12-05" version="1">MNDTTRSIALTEKLGARNYRPLPIVVAESEGVWVRDPEGKRYMDFLSAYSALNHGHRHPAIIRALIDQANRVTLTSRAFHNDRLGEFYEELTRYTGKNMILPVNTGAEAVESAIKAVRRWAYNVKKVPDGLAEIIVCEGNFHGRTITAVSFSSNEEYRRGFGPFTPGFRIVPYGDTEALEKAIGPNTAAFLIEPIQGEAGIVIPPDGYLREAARLCKMNDVLFVADEIQTGFGRTGKPFACDWEDVKPDVYVLGKALGGGVFPISAVAADEKVLGVFDPGSHGSTFGGNPLGCAVAIAALDVMEKERLAERSAELGDYLLDRLSKELGGHPLILDLRGRGLFIGIELAVGARPYCERLMRDGLLCKETHDNVIRLAPPLIITRHELDWAMERLVNALGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG02</accession>
    <name>A0A398CG02_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02126">
        <property type="protein sequence ID" value="RIE02126"/>
        <property type="gene ID" value="D3H35_15320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="81" mass="8721" checksum="8B2EA776A93172D4" modified="2018-12-05" version="1">MVGLSSGIAYEREPQPNVVGLSGGIVYECEPQPNVVGLSSGIAYEREPQPNVVGLSSRIAYEREPQPNVVGLFGEKAYEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG26</accession>
    <name>A0A398CG26_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000043">
        <property type="protein sequence ID" value="RIE00882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00882">
        <property type="protein sequence ID" value="RIE00882"/>
        <property type="gene ID" value="D3H35_25845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="82" mass="9330" checksum="DBB289434DBEB83D" modified="2018-12-05" version="1">MLARRSGQDVVYQLVDNSTEGTLNLLEYQLYDGSTRAVGSKVYSNSLRSIQMNMPSVDGNYSLNLIKQNFRTMWSNCPEVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGF7</accession>
    <name>A0A398CGF7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Epoxyqueuosine reductase</fullName>
            <ecNumber evidence="7">1.17.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Queuosine biosynthesis protein QueG</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">queG</name>
        <name evidence="9" type="ORF">D3H35_16420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>AH2 + epoxyqueuosine(34) in tRNA = A + H2O + queuosine(34) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:32159"/>
            <dbReference type="Rhea" id="RHEA-COMP:10345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82831"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="1.17.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 2 [4Fe-4S] clusters per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the QueG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.99.6" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02306">
        <property type="protein sequence ID" value="RIE02306"/>
        <property type="gene ID" value="D3H35_16420"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052693">
        <property type="term" value="F:epoxyqueuosine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00916">
        <property type="entry name" value="QueG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004453">
        <property type="entry name" value="QueG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013542">
        <property type="entry name" value="QueG_DUF1730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30002">
        <property type="entry name" value="PTHR30002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08331">
        <property type="entry name" value="DUF1730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00276">
        <property type="entry name" value="TIGR00276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cob(II)alamin binding" evidence="7">
        <location>
            <begin position="148"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cob(II)alamin binding" evidence="7">
        <location>
            <begin position="249"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>cob(II)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>tRNA</name>
            <dbReference type="ChEBI" id="CHEBI:17843"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>tRNA</name>
            <dbReference type="ChEBI" id="CHEBI:17843"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>tRNA</name>
            <dbReference type="ChEBI" id="CHEBI:17843"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>tRNA</name>
            <dbReference type="ChEBI" id="CHEBI:17843"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>tRNA</name>
            <dbReference type="ChEBI" id="CHEBI:17843"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>tRNA</name>
            <dbReference type="ChEBI" id="CHEBI:17843"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="410" mass="44626" checksum="1694BEE92A915F6A" modified="2018-12-05" version="1">MAAPLRGDASFWRDLKNEMIAAAPGMGIDRIGVASADPFLLLKERLERHRELGYESGFEEPDLAKRTDPALSFPEARSIVAIAVAYPSKLKGAPVSEPGLRRGILSRSAWGEDYHLVLRRRLEKLAAWLEERVPGARSLSMVDTGVLSDRAVAERAGIGWSGKNSMIITPDLGSWVYLGEMITNLPLPPDKPVEEDCGDCTICIDACPTGALVGPGQLNSQRCVSFITQTKGLVEEELMRKIGNRLYGCDTCQIVCPKNKGIDIRRHEELLPDPETVKPLLRPLLTMGNKEFKTKFGASSAAWRGRKPIQRNALIGLGNFRDGESVPDVARVLREDPRPELRATAAWALGRIGGERARDALAGALEASSPERDEAVLAAVKRALAAIVDDADRVGVTPIAEEQRANEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGM3</accession>
    <name>A0A398CGM3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_16765</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02366">
        <property type="protein sequence ID" value="RIE02366"/>
        <property type="gene ID" value="D3H35_16765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="38"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="360"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="394"/>
            <end position="401"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE02366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="607" mass="68971" checksum="9D2C0488ED80092E" modified="2018-12-05" version="1">MTKERVPRMDKSTIPQLKNLFVRILPMLWKIAPGLFTVSIFIHLLQAAIPSLQLYLTQQLIDGVVSMINNEPGSWNHAVYIVGLQGAALALDNGLRTCGTYVMAATKQKANYELNRIVIDKCSKLPLVYFDQPQYYDQLQRVSKGVEYRGISILEYLFQLLQSVFTIAGFLVILANLHYTLAVGMVLLVIPILLINIKIGKQKYRQMVEQTEKSRKVDYLSELLKEREAAKEMRVFELFPFMKMRWRKLYWDNAGEQIALERRSLLKQFGAELISGIVTLCITFYLLLLTYRGQLTLGSFAALNQALATTRHQLIIAVVNMSRIHEELLFMNEWFAFLSMPEKSDSALSETTGETREEGIQVRNLTFAYPGHSEPVLKNVSFDVKPKQKVAIVGSNGAGKSTLIKCIMALYEPQQGHVSIDGERADKDGARYNKFSVVFQDFVRFQFSVQHSIGFGNLDRLEDRAWAEVAAAKAGASEFIDRMPRKFDTLLGPMFDEGHELSYGQWQKVALGRAFFKDAEFIVLDEPTSALDPIAEAQLFEQFAKLTEGKTTFMVSHRLGSCRFADHILVLKDGRLIEQGTHNELLALNGEYAEMYTTQSQWYETPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGM7</accession>
    <name>A0A398CGM7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_22045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01102">
        <property type="protein sequence ID" value="RIE01102"/>
        <property type="gene ID" value="D3H35_22045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="133"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="330" mass="37188" checksum="01F611656B59B8A9" modified="2018-12-05" version="1">MKIAIVGCGLMGHTHASNLAKMPGVELVGAFDNSAEAAERVAAAYHTKAYVSFDTMMIAEDPDIVCVLLPTPMHKEFVIKSANYGKHVFCEKPIAGSLEEAEEMIAYCERKGVKLFIGHVVRFFPAYSEAQRRIAAGELGRIGVARTRRVGPHPGKFSKWYNQFERSGGVIMDLMIHDIDFLRWVFGEVRSVYTLNYRNQDTMDYALVTLQFDNREIANLEAYWGYPGQFHYALEISGREGLIHFDSREETPLQIFKRGEAESSTTSLSPVNKDPYYLEMLHFIDHIRDGKPLLVTPQDARINIEIAQAAMESARTGLPVYMQERGVPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH79</accession>
    <name>A0A398CH79_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01820">
        <property type="protein sequence ID" value="RIE01820"/>
        <property type="gene ID" value="D3H35_13580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="75" mass="8228" checksum="BA97294E6350CC30" modified="2018-12-05" version="1">MYTLLFILGAAAVVYLLVGSIVLFRKQQRENSTLDKGASMTTVKHPIAANPIFILYLTLPLLAVVLAIIWIAVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH87</accession>
    <name>A0A398CH87_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-serine deaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">sdaAB</name>
        <name evidence="11" type="ORF">D3H35_28410</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00459">
        <property type="protein sequence ID" value="RIE00459"/>
        <property type="gene ID" value="D3H35_28410"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004643">
        <property type="entry name" value="Fe-S_L-Ser_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036692">
        <property type="entry name" value="SDH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00719">
        <property type="entry name" value="sda_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="148"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR036692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE00459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="225" mass="23912" checksum="6C77759DD5B775DA" modified="2018-12-05" version="1">MRFKDVFSIIGPAMIGPSSSHTAGAARIGFAVRQLLGEQPLTARIELFGSFADTYAGHGTDFALVGGLLGLAPDDPGLPESMAEAARLGMAIDLLPSKGVPMHPNTARISARTARSEVVATAASIGGGNIEIQEIDGFEVKMSCAYPTIVLVHLDRQGIVASISAVLTRHSLNIANMQVKRSGRFGETLTVLELDDNWNDGLLAELTAVPDMRSVRTISLEMKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHG1</accession>
    <name>A0A398CHG1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01920">
        <property type="protein sequence ID" value="RIE01920"/>
        <property type="gene ID" value="D3H35_14165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="173" mass="19051" checksum="FCB896A80E6DA2D5" modified="2018-12-05" version="1">MPDAFSLSLRGDSGIKSVADLKGKNHWSGRHRRRSANYAVDRFEAARAGSAERRGMESLPFAAACDRAEKGEIAAFIVWDPAAQQAIDDKKYVRLLSNGHDEPFKSGYCCYLRHQRQSGGGRCADLKRLNRGRCLAGAHDFLSSIALLSGRDPNDERGDLAFLRRRSQAAAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHH0</accession>
    <name>A0A398CHH0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded-DNA-specific exonuclease RecJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">recJ</name>
        <name evidence="11" type="ORF">D3H35_27750</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00539">
        <property type="protein sequence ID" value="RIE00539"/>
        <property type="gene ID" value="D3H35_27750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004610">
        <property type="entry name" value="RecJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018779">
        <property type="entry name" value="RecJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041122">
        <property type="entry name" value="RecJ_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17768">
        <property type="entry name" value="RecJ_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10141">
        <property type="entry name" value="ssDNA-exonuc_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00644">
        <property type="entry name" value="recJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="7">
        <location>
            <begin position="82"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="8">
        <location>
            <begin position="318"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="RecJ_OB" evidence="10">
        <location>
            <begin position="459"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="ssDNA-exonuc_C" evidence="9">
        <location>
            <begin position="572"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="761"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE00539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="819" mass="89500" checksum="18DAE31025614D5C" modified="2018-12-05" version="1">MFASRYRWEWREPDEAGARDLAEKLGLPMLVAKVLSSRGWTDPDAVERFLNAGEQGLEDPFLMKGMTEAVERIRRALKEGERIRVYGDYDADGVTSTALMSRLLAKLGASFDTYVPHRSREGYGLNNGAIDLAAEAGVKLIVTVDNGISAAAQIAYAREIGIDVVVTDHHEPPELLPESACAIVNPKQRDCPYPYKGLAGAGVAYKLAHALLGRPATEYSDLAAIGTIADLMPLTGENRIIARLGLSMMRNDPSLGIQALAAVCGIEAKELSSGRIGFGVAPRLNAGGRLDSAESAVRLLVTEDRSEAERIAGELDLLNSERQRLVEETVKEAEAKWEQRRSDWGGQGPRVIVLTGEGWNAGVAGLVASKLVEKHYRPAIVLAYDAGTGKCKGSARSIEGFDIHAALSECSSLMDHFGGHQAAAGMTLAIDKVPELELALDRIAGERLTAEDWQPKKRVDLVCELTDASLSAVEELSRLEPFGSGNATPRVLIRDLSLRECRTLGKDGKHLRMTVVREGRPLEAVGFGLGECVERLAGGVSVDLLGELSVNEWNGNRKVQLILQDFRSDELQVFDLRDAKDAWKELDKLARSRRGSLLALSPSPRTAGEAKEREGLEGIAVLPYDFDRSGIAATLREVAAGSMLEAEQSGGPRHLALLGLPEKPEEAEALGQVLSELKRLESVHIFKLPGRRSEPGASGSSFPDRSRFGEAYAMFRERGAWIDGPDGYLRQISIRTGMSLAVVRMMQEVFEELGFIRARGAERKMNDNPPRKPLEESERYRKAKRQAEALRLADMPKERLAEWLTGLKTEGSQTTVKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHN1</accession>
    <name>A0A398CHN1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000051">
        <property type="protein sequence ID" value="RIE00619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00619">
        <property type="protein sequence ID" value="RIE00619"/>
        <property type="gene ID" value="D3H35_27555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="125" mass="14345" checksum="22FE0787434FE90E" modified="2018-12-05" version="1">MKASNVDWGVVDSIEVRLEYRQPGGELLSKVLILTEQAGTLSWNIRLDDKTKRTYTYRLVHRLKDGTNRETETFSSEASLLPVDDPFRHLFAFNFCRCLIPRKSKPSSSTWRIPIRTIATNAKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHS7</accession>
    <name>A0A398CHS7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_24755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01562">
        <property type="protein sequence ID" value="RIE01562"/>
        <property type="gene ID" value="D3H35_24755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="185"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="297" mass="34910" checksum="AF39BE2301D7D003" modified="2018-12-05" version="1">MELFKEPILYKDPLLRIQVRSFHTTAICQHGWHFHPQLEIIAVRSGRMEIHTPAEVYHLRAGDVLILGSCQPHLDLRKENEVVDYVVIQFELEAFLDSNMLPVLYLFQESLLPLVRLNSLARDNSELRQQLYSTVMELQQEHEQKQRGYEMAINYLVKKCLFLLLRHDNEGLLEHNRSMNYAKLKVVFDYVEAHLSDKITVEQACLLVNFSYTYFLKYFKQTLGVTFTDYVIQRRIKYAERLLLTEDLSIAQIAERVGLPNISHFYKLFKRVHHCSPKSFKDTIIARANETIHGRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ22</accession>
    <name>A0A398CJ22_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02743">
        <property type="protein sequence ID" value="RIE02743"/>
        <property type="gene ID" value="D3H35_19050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="220" mass="26173" checksum="1424EFA26155B4D2" modified="2018-12-05" version="1">MFEAEWERFVQEQKRTAGPLRLEQLNKNKSGEKKLFEIVVWPIFKSFDGWAMEHEVVMPSGVRIYLDAFYMPFEWSLECEGFAVHAETITRDRFDFEKERIRTMAIYGYRFMPFSRDQLDKKPDACRRFMYEMLGRFSSSASTGYYDLCIYEREIIRYAIRLGRPIRMKDARACLQTSEEHCRSILKKMVSKGLIRPVDETKQRCHAYVLEPLGRHALFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ61</accession>
    <name>A0A398CJ61_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Insulinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_11715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03346">
        <property type="protein sequence ID" value="RIE03346"/>
        <property type="gene ID" value="D3H35_11715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="1">
        <location>
            <begin position="63"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="2">
        <location>
            <begin position="180"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="430" mass="48321" checksum="67CC12B1B7871F2D" modified="2018-12-05" version="1">MTIVEYPGLEEKLWHEKLPNGLDVFVLPKPGFTKTYATFTTRYGSVDNHFVPPGGEAIRVPDGIAHFLEHKMFEEPEGDIFSQFALQGASANAYTSFDRTVYLFSATEQVPANLNTLLHFVQNPYFTDENVDKEKGIIVQEIDMYKDNPDWRVYFGLIEALYSRHPVHIDIAGTADSVRSITKEMLYDCYHTFYHPSNMTLFVVGGVDPEATLKQVREDQAAKSFRPGGEIGRLFEEEPLAVREPIRVLHLPVSLPKCMFGYKEAPGEAVGESAIRRELVSKLMLDAALGASTPLYQQLYDDNLISDGFGHEFNTGSGYSFSVIGGETRDPEELVRRVTDALEKAAEDGIDQAVFERTRRKKIGGFLRMMNSPESIASEFTRYRHKGGDLFKLVALYESITLEEANVRLREHVSADRLAVSIVRSEGDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ88</accession>
    <name>A0A398CJ88_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02380">
        <property type="protein sequence ID" value="RIE02380"/>
        <property type="gene ID" value="D3H35_16840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025945">
        <property type="entry name" value="DHHW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14286">
        <property type="entry name" value="DHHW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="421" mass="46126" checksum="5217E425B07FBD0B" modified="2018-12-05" version="1">MSSSNHHKWNIALFLIPIAAMAVLNLTKPGGSSDISTLEQREVQAWPAFSMDKLVHGKLFKEYDNYFSDRFVFRNTFVELGSSAKELKGLKGDDVSIVVQKGDTGEQMSGGGASAVQLDDSGQLMTGKSSSKYLVVKDSAMLLYHYSPVASEAYAKAINHLDSLVDSSVNVYSMLVPSQVEFVESEKLRKLSDSQKKAFEHVYSLLGDGVKPVPAYDSVAAHKNEYVYFRTDHHWTALGAYYAYEAVAKTMGFAPVPIGAYEKKEMPGYLGTSYAATLSAALKNHPDTITAYVPAVKNEYKVFKDGKNGKKRELVEGKIPKDGRGGYAVFLGGDFAMSRISTDVGNGKKLLVVKDSYANALIPFLLSHFEEIELVDPRYFKGNLVAEIKERGITDVLFVNGPVVTTYTGIAKLVEERLAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJK8</accession>
    <name>A0A398CJK8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Aspartate ammonia-lyase</fullName>
            <shortName evidence="6">Aspartase</shortName>
            <ecNumber evidence="3 6">4.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aspA</name>
        <name evidence="10" type="ORF">D3H35_23595</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-aspartate = fumarate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16601"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="4.3.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.1" evidence="3 6"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01359">
        <property type="protein sequence ID" value="RIE01359"/>
        <property type="gene ID" value="D3H35_23595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008797">
        <property type="term" value="F:aspartate ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006531">
        <property type="term" value="P:aspartate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004708">
        <property type="entry name" value="ApsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00839">
        <property type="entry name" value="aspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="8">
        <location>
            <begin position="11"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="9">
        <location>
            <begin position="406"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE01359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="471" mass="51095" checksum="94DDAF5FB3412315" modified="2018-12-05" version="1">MSDRIEKDSIGEHTVPSGAYYGIQTIRAVENFPITGVSVHPELYVALAQVKKAAAEANAELKLLPGRIADAIIRAADEVAVGGLADQFIVDSIQGGAGTSINMNMNEVLANRALELMGLAKGDYFHCNPNNHVNMSQSTNDTIPTALRLAAYRLSLLLLEQMQTLREALERKEAEFDDVIKMGRTHLQDAVPIRMGQEFGAYSRVIGRDIERISRATNNLLAVNIGATAVGTGLNAKPEYIQLVVAKLAEDTGIPVRSADDLVDATQNADAYTELSAALKVCSVNLSKMCNDIRLMASGPRTGFGEIKLPSRQPGSSIMPGKVNPVMAEVVNQVAFQVMGNDHTICMASEAGQFELNVMGPVIAFNLLQSLKIMRNALVVFVDYALAGMEANRERCRSYVEQSFGIVTALNPHLGYDVAAQLVKEALRTGLSIKEIILERHLLTPEEMNEILDPIQMTTPGIAGEHLLKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJP9</accession>
    <name>A0A398CJP9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_16745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02362">
        <property type="protein sequence ID" value="RIE02362"/>
        <property type="gene ID" value="D3H35_16745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02857">
        <property type="entry name" value="E_set_CDase_PDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004185">
        <property type="entry name" value="Glyco_hydro_13_lg-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02903">
        <property type="entry name" value="Alpha-amylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="135"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="584" mass="67165" checksum="5D6662A43E917B6D" modified="2018-12-05" version="1">MLKQAIYHRPKQNWAYAYDRATLHLRIRTGRGDVSAVNANWGDKYAWKETSKIEPMKLFASDDLFDYWEIAVVPPYRRMRYAFEFISGKETLYLTEKEFTEQLPDEPWTFFDFPYINPVDVFQPPAWVKDAVFYQIFPERFANGDPSNDPENVEPWGGTPTPKNFFGGDLQGVIDHLDHLEELGVNAIYFNPIFEATTNHKYDTRDYLKVDPQFGTNELLKELVDKCHARGIRVLLDAVFNHSGKTFPPFVDVLEKGAESKYAGWFHVREFPLRFEDGVQTYDTFAFEPIMPKLNTENQEVREYLFEVARYWIEEIGIDGWRLDVANEVDHRFWRDFRDVVKKVNPDAYILGEIFHDSIPWLNGDQFDAVMNYPFTEAVLDFAARGTRDSKQFADLIGSLLASYPQQVNEVAYNLLGSHDTPRLLTLCEEDKRRMKLASVIQFTFAGTPSIYYGDEVGLTGINDPGCRKCMEWDEEKQDRDLFGFFSELVRIRRNNRALRDGSYELLSAESGKLTLAYAREADGERFVIAVNAGKRKASLKAPLSGELIGNASIVFGEAEVSINGNKLNVALPPFGYAIIRLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJU2</accession>
    <name>A0A398CJU2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_24115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01449">
        <property type="protein sequence ID" value="RIE01449"/>
        <property type="gene ID" value="D3H35_24115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="267"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="510" mass="55299" checksum="2242E48FB9153B4B" modified="2018-12-05" version="1">MAKDNGPIPYLLRTNGLTKRFGSLIANRSIDLEVSPGSIHAILGENGAGKSTLMKMLYGVYEPDEGDIFMDGERVALHPPTKARARGIGMVFQDFRVVPALTVLDNIALAVESGWRFNRKKLRQRIVDTSTKYGLAVDPDAYVWQLDLGQRQRLEIVKVLLAPGTRIIIFDEPTSVLVPQEVESFLKMLDLLRKDGYGILLITHKINEVLACADQVSVLRSGQITYTAAREDGLEGDTLISAMMGDKSLKPVMKPGADTARDTEAALQISGGKIVGDHGESVLTDLQLTLPKGQIVGVAGISGSGQRELAEVLFGLRKLTAGTLTIGGTEMKEGTKAFMEAGVSFVSEDPIKESVIPGFSIMEHMVLDGIPLKPKGAGIDWKHIRSELDSSVEAEALALADGSRRADTLSGGNVQRMVLTRALIRKPEILIISYPSRGLDIGTTRTIQQHLIELAEQGTAILLFSEDLDELFKLSDQLVVLSGKRLIGPYLPSETDAAQIGYRMLKGESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK36</accession>
    <name>A0A398CK36_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01228">
        <property type="protein sequence ID" value="RIE01228"/>
        <property type="gene ID" value="D3H35_22810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="210" mass="23018" checksum="AA9FDE1E315F063D" modified="2018-12-05" version="1">MRRSAAKAISTGVHDIFIERPVNGTNLIIITTDCGGAAEEGIDANAIPNGTVVRLRRNAVSQLVTTFTESASECTQNAIRISPAMAKKFGIVNDTRYTVTYNSVTRVLRLCRKPVTELQVSPVLSAQQKIGTIGIGDGLAAQFGINLRSGMFITVVRRRVRLRLRYMELFDPDFFSYAYNLNPADALKLGITGKETTSAYNQITRTLVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKE5</accession>
    <name>A0A398CKE5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_09490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyltransferase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03776">
        <property type="protein sequence ID" value="RIE03776"/>
        <property type="gene ID" value="D3H35_09490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="33"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="121" mass="13684" checksum="E9273D8635BBD8F4" modified="2018-12-05" version="1">MEPYIDIRTTMIQNVYKTSIVRSVSIMKERYEQLDALRGLAALTVLFSHLAMTPANVPPLVHQFLYRAYSPFSILIKGHQAVFFFFVLSGFVLSLPLLRGSKLNYTAISSVGFAEFTSLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKF5</accession>
    <name>A0A398CKF5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Arginase</fullName>
            <ecNumber evidence="3">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rocF</name>
        <name evidence="4" type="ORF">D3H35_23590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-arginine = L-ornithine + urea</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01358">
        <property type="protein sequence ID" value="RIE01358"/>
        <property type="gene ID" value="D3H35_23590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="PTHR43782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="316" mass="33373" checksum="45FA09B6783F3125" modified="2018-12-05" version="1">MNRLRKPIGVISVPFDLGAARRGAAGGPHAIMQAGLEADLRRLGYDVHRYEPFPVDDGATIDLGTDKDAIATEGANTAQSKLNFVREVAAANRLLAEQVAATAARGQFPLVLGGDHSIAVGTIAGMADRYANLGVVWFDAHSDLNTAETTPSGNIHGMSLAASLGLGPPELTGIRGHAPKLKPENVVLIGTRSLDQGEKELIRASNITCYTMHDIDRKGIPLVMEETIRKLSGSCDGVHLSFDADSVDPLFAPGTGTPVRGGISYREAHLALELLCEAGIVTSAEFVEVNPAIDIRNETARLTVELIASLLGDTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKG4</accession>
    <name>A0A398CKG4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_30125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000064">
        <property type="protein sequence ID" value="RIE00171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00171">
        <property type="protein sequence ID" value="RIE00171"/>
        <property type="gene ID" value="D3H35_30125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="5"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="95" mass="10682" checksum="B980FD1A82FC3ED6" modified="2018-12-05" version="1">MVITDMEMPEMTGIKLAKAIKKENEKIPVILLSFVGDEAKKKHPGLFISVLTKPVKQLNLCKAIHTALGGSETEQKDKAKKRFQMILQRTIRCGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKM2</accession>
    <name>A0A398CKM2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03856">
        <property type="protein sequence ID" value="RIE03856"/>
        <property type="gene ID" value="D3H35_09915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="82" mass="9138" checksum="9905882557AA56E3" modified="2018-12-05" version="1">MHNSLSLEGDAASPARIGIAKVAMRSRALRYRPVDNAYAWKRHSIRDPALAVKCRNLPEKTAASRTGANDVPRLLIEQLPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL00</accession>
    <name>A0A398CL00_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0473 protein D3H35_21060</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_21060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0473 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03075">
        <property type="protein sequence ID" value="RIE03075"/>
        <property type="gene ID" value="D3H35_21060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01448">
        <property type="entry name" value="UPF0473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009711">
        <property type="entry name" value="UPF0473"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40066">
        <property type="entry name" value="PTHR40066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06949">
        <property type="entry name" value="DUF1292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="101" mass="12023" checksum="853DFDE6D5652D74" modified="2018-12-05" version="1">MADEQNLHEDEAEIIYIPDDEGNEEAFEVIMRFELDDGTDRKYLMVVPEEDTEEEQEVFAFRYEEENEEIQLFPIESEEEWEIVEETFNTLMGEFGGEKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL29</accession>
    <name>A0A398CL29_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01608">
        <property type="protein sequence ID" value="RIE01608"/>
        <property type="gene ID" value="D3H35_25020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044048">
        <property type="entry name" value="Big_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025883">
        <property type="entry name" value="Cadherin-like_b_sandwich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19078">
        <property type="entry name" value="Big_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12733">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="SSF50985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="742"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="805"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="870"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="924" mass="94963" checksum="8417BF41699E4230" modified="2018-12-05" version="1">MGSSADGRNHVPSGLDGVVAIAAGTAHSLALKSDGTVVGWGYNTNGETNVPAGLTGVVAIAAGAAHSLALKSDGTVVAWGKSDVGQTNVPADLDGVVAISAGYNHSLALKADGTAVAWGLNGNGQANVPGNAKLSDLTLQQGDFTESFQPSVTAYTYYFDGHSLSSVDVTPTLASGARAGIYMNNELLPSGGTKTINIAGATTDTVIPVRVEPYLLSGQTYTITLAIDSTDPAVLFGTNGRATAATSAATKVTVTDTQSGVDGNSLQYAWTQSTAVPTGGWAAFSNEDTLSRTSGDGNWYLHIRASDAVGNVVDAVSSPYVLDNTAPTATVSSSASGTVNASFPVTITFSESVNGFTEADLEVANGTASNWVSVTAATYTATITPTMSGQAVTVAVDAGAATDAVGHGNTASNTLSLLYDTTKPIVAFGGFTDHQRFAAPPAEASVTVSEAVYWVAGGAQLTSANALPLISMTKDGGAFSAYTPSYDEPSRTFTLSFSGTLDDGVYEVNVAGDAVENAIHNTLDAASASFVVAMPVVANISASPTGLPRAGGNAAVTITGANLTGQTVKVYVDGVEAATATVGSDTSATATVSLPRNAALTVRSYLLTVYLNGAEVASLSSTVTVAAAPPPTTTINLSSNSELAKLNVNASGKPLGLSPEFKPETTEYTAETDAEQIELRVAPAHSNAIVTLLGTRIGETTAVPLAMGANVLTITVQAEDGTVKTYTLTINRLASGEEESSAPVCAFTDIEKHWAKPAICEAAELGIVEGVDAHTFVPNGYITRTEFAVMLLRTLQLPIRNESSEMSFSDRTSIPEWARLSVQTAVAEGILEGYSDGTLRPTRTINRSELAAMVSKVMKWEAGNAASPFFADDARIPVWAKAYVEAARVHGILVGRAGNQFIPNGLTTRAEAAVVLLRLWKALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLA9</accession>
    <name>A0A398CLA9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_19570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03205">
        <property type="protein sequence ID" value="RIE03205"/>
        <property type="gene ID" value="D3H35_19570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="269"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="314"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="362" mass="41260" checksum="24048F2D794C1D25" modified="2018-12-05" version="1">MIVRDEEKWIGRCLASVKDAVDEMIVVDTGSTDRTADICRSFGASVHPFPWNGSFADARNESLKHATGDWILWLDADEEADALSAARLRDVLEWQEDSLGFVQLVNYYGASPPESNRSFLLAHHRLFRNGIGFRFGNTIHEQLNVVEVLGDVPRMCLLPVSVYHYGYMDAVTADKNKFDRNLALLLKEKEQPDCSPWVDYHIASEYYRIADYRQSFEYVNKSIVQFLNRSQMPPSLLYKLKYSVLFALNSHEGAWPGIESAIKLYPDYVDLHFYKGVILFRKEKYSEALEAFKQCLELGESNLRHLTLKGLGSFQAWYYIGRCLEKSSDISNALQAYRETRALDPAHKEAAEALAAIEDAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLB7</accession>
    <name>A0A398CLB7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03012">
        <property type="protein sequence ID" value="RIE03012"/>
        <property type="gene ID" value="D3H35_20670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="569" mass="66055" checksum="7BE44462AF80C86B" modified="2018-12-05" version="1">MTDRWSEGNQTLAPILVGVTGHIDLIEEQIPKLRQLVKETLLSYARQYPNTPMILLSPLAAGADQVAAEAALQLRDMEGLQIQLYVPLPMPKLEYLKHFPDEKSVDRFHDLLEIADHHYVIPAVEGIEQVIENRETYYSKVSDHITKYCHILIALWDGIEKSSLKAGTSYTIRSMRDGIESELTDSNKLLDPVTSGIVIRIRTPRQSNPNILKPLTVDEPIYPTNFPFETGQEVFGRILQHIEQFNEDVRREENKRTRTDPSDDTLGWRSRTAPGPLQRIAKLYERCNEFAIRLKKQRMALFRNLLTLAVLLVCFYEFMSMYPFLVAGYAVLLGAAYYQYRRGRKLELHRKFLDYRALAEGLRIQFYWSLSGIEKDVSDFYLSQQRSEVEWICSVIRSQHYLNQAHRVPKYDHLQWVKDNWIGKQYMYFVDSARNNQEKGMKSAARFRLLFVSGVLLIFSIYAGNLFFDWFQMTGVASWLLIPAASLVAYSIAYNNYSQQQSYSYIVAEHSRMATLFEYGLKKTNEYLNAEKPESARKVILKLGQEVLDENGSWVYMNRERDIHLPTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLD0</accession>
    <name>A0A398CLD0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Shikimate dehydrogenase (NADP(+))</fullName>
            <shortName evidence="6">SDH</shortName>
            <ecNumber evidence="3 6">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">aroE</name>
        <name evidence="10" type="ORF">D3H35_05885</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="3 6"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04156">
        <property type="protein sequence ID" value="RIE04156"/>
        <property type="gene ID" value="D3H35_05885"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00222">
        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011342">
        <property type="entry name" value="Shikimate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00507">
        <property type="entry name" value="aroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="8">
        <location>
            <begin position="10"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="7">
        <location>
            <begin position="115"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="9">
        <location>
            <begin position="246"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate binding" evidence="6">
        <location>
            <begin position="18"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="130"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="154"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="283" mass="30134" checksum="047B11720872CEA2" modified="2018-12-05" version="1">MDSHTVLYGVIGDPIRHSKSPIMLNRAFKETGVNGAYGAFHVASERLGDAINGIRALGFRGLNVTIPHKIEVMAYLDDIDESARAIGAVNTIVNDGGRLVGFNTDGIGYVRSLMEEAEPDLAGKRIVVVGAGGASRGILWALARQRPGAVWLANRTQDKASELADDLGGKANSIEAIPWERLREACGEADIVVNTTSVGMSPNVEAVPLDPAWLKPGAVASDLIYNPLTTAFLEGARQQGCRIHGGLGMFVYQGAYAFEYWTGLPAPVAAMREAVLESFGQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLR7</accession>
    <name>A0A398CLR7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_18135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03182">
        <property type="protein sequence ID" value="RIE03182"/>
        <property type="gene ID" value="D3H35_18135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="4">
        <location>
            <begin position="73"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="282" mass="32266" checksum="1693AE3828B0EFC6" modified="2018-12-05" version="1">MEIRLPDTLAGAPLPRILPHLPLAPKLISKLSQSRGLLLQGPNLRLQLFPRERRDFESDWMELNVLYEDEFTLVINKPAGYEVHPSEKGQRRTLAHAVAAYYEMSGQDVRIRHIHRIDKDTTGPVLYAKNEFAHYQFDKAMREKKIERVYLALAEGVLEKKQGTINKPIGQDRHHSTKRRVSETGDPAVTHYEVVERFADHTLVRLQLETGRTHQIRVHMAAIGHPLAGDGLYGGKRTVMSRQALHGERLIWSHPWTGDKQQVQAPLPEDFNQALKRLRGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLW0</accession>
    <name>A0A398CLW0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="15">DAD</shortName>
            <ecNumber evidence="14 15">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">ilvD</name>
        <name evidence="16" type="ORF">D3H35_21170</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14 15"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03232">
        <property type="protein sequence ID" value="RIE03232"/>
        <property type="gene ID" value="D3H35_21170"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="15">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="15">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RIE03232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="556" mass="59559" checksum="C726F34FE5A725EE" modified="2018-12-05" version="1">MRSDMITKGFDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYIDIVPGHVHLQEFGKIVKEAIREAGGVPFEFNTIGVDDGIAMGHIGMRYSLASREIIADSVETVVNAHWFDGMVCIPNCDKITPGMLMAALRVNIPTIVVSGGPMKAGRTSDGRAISLTSVFEGVGAFMSGKIDEKSLTELEQYGCPTCGSCSGMFTANSMNCLAEVLGLALPGNGTILAVAEERKEFVKKSARQLMELIKLDLKPRDIVTKNTIDNAFALDMAMGGSTNTVLHTLALAHEAGIEYPIERINEVAKRVPYLSKLAPASDHHIEDLHNAGGVSAIIHELLKKDDALFGDEMTVSGKKLRENVEGCEILDKTVIRPIDDPHSKEGGLSVLFGNLAPNGSIIKVGAVDKSVGGYHRGPAICFDSQDDALAGIANGKVKEGHVVVIRYEGPKGGPGMPEMLAPTSQIVGMGLGTKVGLITDGRFSGASRGISIGHISPEAAEGGPIAFVNDGDMIELDMNNRTITLEVSDEELERRRANWPGFEPKIKRGYLARYSYLVTNASQGGVMKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLX2</accession>
    <name>A0A398CLX2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_26085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000047">
        <property type="protein sequence ID" value="RIE00847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00847">
        <property type="protein sequence ID" value="RIE00847"/>
        <property type="gene ID" value="D3H35_26085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="65" mass="7296" checksum="FAE5847985DD3F5C" modified="2018-12-05" version="1">MSDAKREEAGEVKEVKTGAAKLKSEAYFQEKDLWGSFIVRSRNRWGTQRKISASRSSAFAIRSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLY8</accession>
    <name>A0A398CLY8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">12-oxophytodienoate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03455">
        <property type="protein sequence ID" value="RIE03455"/>
        <property type="gene ID" value="D3H35_12410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="PTHR22893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="16"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="374" mass="40938" checksum="BE5FFC3EF1BFB390" modified="2018-12-05" version="1">MSSQESTADEVTVQALFEPYQEGNLKLSNRIVMAPMTRGFSPNGVPGPDVADYYRRRAANGVGLIVTEGTLINHPAAAASPNWPNFHGDEALQGWAKVVEAVHSAGGRIIPQLWHVGTTRKIGSLPNPEALPVGPSGIDAATGEQVSEPLSEQEIASLVEAFAQAASDAKRIGFDGIEIHGAHGYLIDQFFWEKTNRRTDRYGGSLAARTLFATEVVKACRQAVGPDFPIVFRFSQWKGADYSAKLVQTPEELEQFLAPLAEAGVDVFHCSTRRFWEPEFEGSDLNLAGWTKKLTGKPTITVGSVGLDVEFTKRDESANTVTLDKLLDRLNRGDFDLVAVGRALLHDPEWAVKIRDGRSDELRPYSQESTKTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM46</accession>
    <name>A0A398CM46_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cortex morphogenetic protein CmpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cmpA</name>
        <name evidence="1" type="ORF">D3H35_25585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00937">
        <property type="protein sequence ID" value="RIE00937"/>
        <property type="gene ID" value="D3H35_25585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="50" mass="6210" checksum="09BAD372325FAC0B" modified="2018-12-05" version="1">MPQWLCNQLMRAFQKKDRRQIRLLNDCWFYYRTRPDHTDAKDQNPMGIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMP5</accession>
    <name>A0A398CMP5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04636">
        <property type="protein sequence ID" value="RIE04636"/>
        <property type="gene ID" value="D3H35_03850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="146" mass="16585" checksum="8A9EDD3A90AE67AE" modified="2018-12-05" version="1">MNRSGLDDSIGFRLGITYRKLSHLFNQRLKSYELTPEQWAVLVRAAETDGSMQKDIAERAGKDRPTTTRIIDALEAKGFIVKRAGDHDRRSFLVFATEKGKRTVKEVEPLESRTMDEAMEGISPSDRTLLFELLEQINVNADKLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMQ7</accession>
    <name>A0A398CMQ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_11075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03572">
        <property type="protein sequence ID" value="RIE03572"/>
        <property type="gene ID" value="D3H35_11075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="184" mass="19892" checksum="AD1AB017A3672740" modified="2018-12-05" version="1">MFKEIFDLFVAFGRSTMFGYGGGPSIIPFYQNEVVNRYHWMNTEEFGQALAFGNTLPGPIATKLAAYIGYKVAGWAGAFAAVTAVVLPTALLMVLLVGVMSKLQNNAYIKGMIKGVQPVIFVMLAMLAYDFAKFAFQRSGGPIAFLPFALAAVFFVCVQYLKLNAVWGIAGSLVVGALFMRDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMU5</accession>
    <name>A0A398CMU5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03933">
        <property type="protein sequence ID" value="RIE03933"/>
        <property type="gene ID" value="D3H35_08185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="144" mass="16428" checksum="796F806871AFFC9B" modified="2018-12-05" version="1">MLDIIFNESSININKKGAVTGEIYFNVDNEYFPGYNWSDFIVVILTWWNKSINQLELSPVGVAVNFSFMDGPFNIRGEKKENDSVTLEFIKRNASGENISISIDMSILELKRLIQKVSRNVLNVINTTNSVFNDDIEELKKIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMY2</accession>
    <name>A0A398CMY2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01267">
        <property type="protein sequence ID" value="RIE01267"/>
        <property type="gene ID" value="D3H35_23040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="217" mass="24024" checksum="11B8711B014FF3AD" modified="2018-12-05" version="1">MGEAGLPFRRHPDVGPSGKVTIMGPSRCNAERMAAYASRRNSSVPDLAHAYLRFGAEYGVRGDVAYCQALYDTRAWTTEPAGSPWKPLALSSGRSVSDEASVEQHIQLLHAFAANKSAGYEESAEVAERRSRMERAGWLGTVRHWEDLNGKWQLPGSKYGQDIVAIWRGMMEWSGKGEVHVDIETQQTPEDRSLGDTKTGSIMSRVSRFRAARTCYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNH9</accession>
    <name>A0A398CNH9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_28235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000055">
        <property type="protein sequence ID" value="RIE00474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00474">
        <property type="protein sequence ID" value="RIE00474"/>
        <property type="gene ID" value="D3H35_28235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="183"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1180" mass="132145" checksum="C1E26BD11F58ADEF" modified="2018-12-05" version="1">MHIVDAGGRLLQPIGIPGELCIAGAGLARGYLNQPELTAEKFVANPFAPGERMYRTGDLARWLPDGNIEYLGRIDEQVKVRGHRIELGEVESALRSHESVKEATVIARKDEEGSAYLCAYFVTNGNLGASELRKHLLKMLPQYMIPSFFVRVEQMPLTPNGKLDRKALPSPEGTLERGTVYEAPRNALEETLANIWQGVLGVSAIGITDNFFELGGHSLKATTLVSRIHKELNVQVPLREVFQSPTIKELAQAIRGMEAHAYASIEPAPLREYYPVSSAQKRMYILSQLQGADESYNMPGAVMMEGKVDRERFERAFRQLIARHEALRTSFEWVEGEPAQRIHLEVDFEISYKKAEEDGLRQIAEFIRAFDLGQAPLLRVGLLELEPERQVLLYDMHHIISDGVSMDILVREFVGLYGGQTLPAPRLQYKDYAVWQQAFMQSEAMKRQETYWLETFSGELPVLEMPTDYPRPAVQSFKGDQIQFELDGELSAGLNRIAAETGTTLYMVLLAGYSVLLSKYTGQEDIVVGTPIAGRPHADVENIIGMFVNTLAMRSRPAGEKTFTAYLQEVKEVALQAYEHQEYPFEELVEKLNVRRDLSRNPIFDTMFSLQNMSEEETEIEEMRFSPYGFEHSASKFDMSLTAVETGREIGLSLSYCTAIYTKETAERLGRHYVALLRDISSQTEKQLKAIELLSAEEKRQLLHAFNDTKATYPANQTIHGLFEEQVKKTPDHTAVVLESESLTYAELNGRANQLARVLRGKGVGADRIVGILAERSLEMIVGILGILKAGGAYLPIDPDYPAERIGYMLEDSGADILLTQKRLEAQTMGFAGEVLHVDDERLYAWMTPISRIRQFQRSGVCDLYFGLHGEAEGRHDNHQGLVNYVSWANTVYMQEDRLDSALFSSISFDLTVTSLYLPLITGNKVVVYHGENQASVIKRIIEEDKVGLLKLTPSHLKLLETDMHLSSSTSMKRLIVGGEDFSHALAQSIYEKYEGKVEIYNEYGPTETVVGCTVYLFDAGSKGYTSVPIGVPASNVQIYILNSYMQEVPIGVAGEMYISGDGVSRGYLNQPELTAEKFVANPFAPGERMYRTGDLARWLPDGNIEYLGRIDEQVKVRGHRIELGEVESALRSHESVKEATVIARKDEEGSAYLCAYFVANGNLGAAELRKRLSEMLPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNR3</accession>
    <name>A0A398CNR3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF386 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03972">
        <property type="protein sequence ID" value="RIE03972"/>
        <property type="gene ID" value="D3H35_08410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004375">
        <property type="entry name" value="NanQ/TabA/YiaL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037012">
        <property type="entry name" value="NanQ/TabA/YiaL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34986">
        <property type="entry name" value="PTHR34986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04074">
        <property type="entry name" value="DUF386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00022">
        <property type="entry name" value="TIGR00022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="157" mass="17908" checksum="B4DAC666826E2B28" modified="2018-12-05" version="1">MRLGSKLSWEKERVFEHPAIVKAVEALIDIAERNPEPGRIEIDGDRLYVNVMTFDAKSPKDQVAEKHERYIDVQYLIDGEETIGWFPLREELEPSKPYVEEDDYALYAPAGDEVPLRLAPGMFAIFFPHDIHRPGMGEKGGKIKKAVAKVRMDLLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNS6</accession>
    <name>A0A398CNS6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000028">
        <property type="protein sequence ID" value="RIE04145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04145">
        <property type="protein sequence ID" value="RIE04145"/>
        <property type="gene ID" value="D3H35_07805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="61" mass="6398" checksum="E39BD510971E074A" modified="2018-12-05" version="1">MENKSHKGNYKGTTNMAAKNQDMAFVNDTLENTKSVAPTPAPTKKRTNLSVPGSSGAASSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPD2</accession>
    <name>A0A398CPD2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_13265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01767">
        <property type="protein sequence ID" value="RIE01767"/>
        <property type="gene ID" value="D3H35_13265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025584">
        <property type="entry name" value="Cthe_2159"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14262">
        <property type="entry name" value="Cthe_2159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017293660" evidence="2">
        <location>
            <begin position="33"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="593" mass="59156" checksum="CBBBDCCED330AD97" modified="2018-12-05" version="1">MKNAWSIKQWGVLLLCAVTLSACSAKSGTSSGEGTSTATGATAVQSSEAATNVQLASVDLTEKIEYDDDDAYTDWSAANPTVIKLSGASATVDGSGAEAKGGTITITAAGTYAVSGKLDEGQIVVNVPDKGVVRLVLNGAEIHNSSSSAIYVEEAGKTIISLPEGTENVVSDGTAYVYPDASTDEPNAAIFSKDDLTINGTGKLVVEGNYNNGITSKDDLKITGGALEIHAKDDGLMGRDLVAVQEGDITVEAGGHGIKTTNDAEDSLGVIAVAGGTFDIDSGEDALHSSGGIQIAGGNFAIAAGDDGIHADVAIAIAGGTIDIANSNEGIEAPTIAISDGKISVVASDDGVNVAGGSDETAAADGPPGGNESGADSGRKLTISGGYLAVDAQGDGLDANGSIEMTGGTVIVNGPTENGNGALDYDGTFVMTGGFLVAAGSSGMAQATSEQSTQSGVLMTYPQTQQAGTIVHLEDSDGNAIITFAPSKNYQSVFVSSPNLKKDASYALYSGGASTGNDANGLYDGGEYQGGTKVVEYTVSSVVTWLNESGVTEARSGMMGGGGGPGGGNRGQGGGGGDRMPPDGNGERPQRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPN4</accession>
    <name>A0A398CPN4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04495">
        <property type="protein sequence ID" value="RIE04495"/>
        <property type="gene ID" value="D3H35_07105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="14"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="245" mass="26722" checksum="D5D3D6664BE83865" modified="2018-12-05" version="1">MLDIAAPVLGRIDTVHPALLWDNQSALLVDTGFPRQIGQLREAVEKAGLPFDKISRVVITHQDIDHIGNLPELANELAPALQVLAHEAEKLYIQGERRLLKFSDEAIASIDRLPPEIPEQFKLGLKALMLNPPSAPVDRTVRGGERLPWYGGIVVIDTPGHSPGHISLYHEPTKTLIAGDALTVVDGNLCGPSPETTPNLEQALLSLQQLASFDIDTVICYHGGLYRGDIRARILEIACKASPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPP4</accession>
    <name>A0A398CPP4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">def</name>
        <name evidence="3" type="ORF">D3H35_07335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04392">
        <property type="protein sequence ID" value="RIE04392"/>
        <property type="gene ID" value="D3H35_07335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="164" mass="18209" checksum="653080FC0BC3F70D" modified="2018-12-05" version="1">MSIRLIVKHPDNVLRERAQEVTKFNSNLHKLLDDMVDTMYEADGVGLAAPQVGILKRVIVVDCGDEHGGLIELVNPEFVNGEGEQFGPEGCLSIPGLQGDVRRYNKVVVKGQDRNGQPVQYEGTELLARAFLHEIDHLNGVLFIDLAESVYEARKPSDEEEEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPP6</accession>
    <name>A0A398CPP6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00934">
        <property type="protein sequence ID" value="RIE00934"/>
        <property type="gene ID" value="D3H35_25540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017428469" evidence="1">
        <location>
            <begin position="25"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="149" mass="16157" checksum="9BB54E6C5C376896" modified="2018-12-05" version="1">MKKFKFSILLSLCLLLFGAQSAFAADPYESPANDTPSTAWILTQGTAYNFFAGSGDMDWYKFTTAKTATQNVFFAPPDTQSYTVAVYDAYQLDNSNGQSISPLAIKTVTSGPGTYTNLNWSATAGKSYYVLVYGGPNITSTYQLVITAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPT2</accession>
    <name>A0A398CPT2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="3">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_05480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04545">
        <property type="protein sequence ID" value="RIE04545"/>
        <property type="gene ID" value="D3H35_05480"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011270">
        <property type="entry name" value="Pur_Nuc_Pase_Ino/Guo-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="PTHR11904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01700">
        <property type="entry name" value="PNPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="5">
        <location>
            <begin position="26"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="274" mass="29301" checksum="FC51447086375985" modified="2018-12-05" version="1">MAVITKAIIDEAAAYIASRTKVKPEIGLILGSGLGVIGDELEDAVTLPYEEIPHFPVSTVEGHAGELVLGKLQGRSVALMRGRFHMYEGYEPERTALPVRVMKALGVGTLLVTNAAGGVNLGYEPGDLMVISDHINLTGRNPLVGPNDNALGVRFPDMSEAYSKRLRAIAKETAASLGFELREGVYVGLLGPNYETPAEIRMLRTLGIDAVGMSTVSEVIVARHSGLEVIGISCISNMAAGILDQPLSHEEVMETSEKVKDRFISLVLALLPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPV7</accession>
    <name>A0A398CPV7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine-type D-Ala-D-Ala carboxypeptidase</fullName>
            <ecNumber evidence="4">3.4.16.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D3H35_05440</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04583">
        <property type="protein sequence ID" value="RIE04583"/>
        <property type="gene ID" value="D3H35_05440"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015956">
        <property type="entry name" value="Peniciliin-bd_prot_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012907">
        <property type="entry name" value="Peptidase_S11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037167">
        <property type="entry name" value="Peptidase_S11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07943">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00936">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69189">
        <property type="entry name" value="SSF69189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBP5_C" evidence="15">
        <location>
            <begin position="274"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="12">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RIE04583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="382" mass="41554" checksum="B477EB27B3320308" modified="2018-12-05" version="1">MAAALVWMPAAATAAEEKKSVKPATDMAANARSAILMDADSGTVIYEKNSTEALPPASITKIMTMLLVMEALDQGRLKLTDKVQTSEYAASMGGSQIFLETGEEMTVDDMLKGVAMASGNDASVALAEKLAGSEDEFVKMMNAKAEQLGMKNTKFANCNGLPAAGHVSSAKDIAIMSRELLKYDRTTKYTGLYQDYLRKDSPKPFWLVNTNKLVRFYTGADGLKTGFTSEAKFCLSATARRDNLRLIAVVMGEPNTKTRNAEVSHLFDYAFSQFTNVPIFKKGETIGTLNVEKGKTNKVELVAKHPYSVLLRKGDAGKGIRHELAISDLKAPIRAGQPIGKLIVYRGNEVLTEFALEAPADVARAGWWKLFKRSAGKLFLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPY9</accession>
    <name>A0A398CPY9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4179 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_14040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01897">
        <property type="protein sequence ID" value="RIE01897"/>
        <property type="gene ID" value="D3H35_14040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025436">
        <property type="entry name" value="DUF4179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040680">
        <property type="entry name" value="DUF5643"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13786">
        <property type="entry name" value="DUF4179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18705">
        <property type="entry name" value="DUF5643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4179" evidence="2">
        <location>
            <begin position="50"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5643" evidence="3">
        <location>
            <begin position="237"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="457" mass="52079" checksum="6233E7A99E30DFB9" modified="2018-12-05" version="1">MTDGARTERFGFDEDKAVYDVERLERFDEAVRAGMARGRIERNRSRMRIRRRVALTAAVGALLLACLFSLRVSPVFAAMVSRIPGLETFVDLVRVWSGDRSVELAMDNDMIQPVGITDERDGIRFTVEGIVADERRLVVFYSIYGMKDPKSAYPEFPSVTTIDGGELQAMIGWTNPFDDMRLQKKSDVQRGTLDIRLLSGLQMPEEVVMKLKLPAEQGDLPFQVIIPIDRAKFAGMTKEYPLNRTVVAEGQTITFVKAVVRPLQTEIHIEYDEKNAKQVFDAGDIKLVDDKGEQWRFTSGGGGVGENRDIVYFESNYFRKPKELYVEGSWFRALDKNNREIVIDTERGVLLKAPDDQLRLEVSKQANGDAQLKLMLNLPLEDHMGYTLLDQSFKDATDKEFRLSDSSGTKTALSPGEDRNEQTGYYYVTKNSYAQPLVFRVPSYPQYIREPYKIRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ80</accession>
    <name>A0A398CQ80_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_03720</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04612">
        <property type="protein sequence ID" value="RIE04612"/>
        <property type="gene ID" value="D3H35_03720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="68"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="249"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE04612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="484" mass="53371" checksum="0EFB95AA63177833" modified="2018-12-05" version="1">MAIWRTVVGKLWLTIILLVAVVISSIGLFSLKYIDLTFSDPNKVKHLFIYVGIIGFTLTTVFAFFLLTKITQPLREMKEAADRVSHGEYSTRVTIRSSDEIGELANTFNQMASELETLIRALQHERRHLSSVLNSMNDAVVSFDAEGGIMLTNPQGRHLMEEWAEVEWGDDEEDSGFTGSVPGPLLETFRSVISGRKELTAKIHVQSGVWSIVMTPLASTDSVRGAVAVLRDVTEEFRVEKLRKDFVANVSHEIRTPLSMVQGYSEALLDDIAGSPEERRELVQVIHDESLRMGRLVKDLLDLARMEAGHLEMTFQSVDVSALIGRVYRKFAVLAKDRGISLTKNESEIPLVLETADADRLEQVLTNLLDNALRHTPAGSGIQMQTKKVESPRGDSIVLTVSDEGQGIPAADLPYIFERFYKADKARKRENGGGGTGLGLAIVKNLVEAHGGKIKAASDLGKGTVFTITLPVKRRSAGGRSRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQA3</accession>
    <name>A0A398CQA3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02948">
        <property type="protein sequence ID" value="RIE02948"/>
        <property type="gene ID" value="D3H35_20290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="382" mass="41927" checksum="68F6CED77ED61EE0" modified="2018-12-05" version="1">MNDTEKWDRLLKQALAPEAEPDEKLNESIISQLKENNRSKRSYRKRISAAVLVAVFTLVMSVTAFAASQFFSSKQVAEHLGEQILAKAFDSSDAIEINQTIDSGDYSFTLHGIVSGAGLRELKSSAQDIYPDRTYAVVSVARQDGGPMPSTSDPEYGKEPFFVSPLIKGQKPWQVNIATMNGGYSEVVLDGIMYRLIECDGVEMFADRGVYLAVSSGSSFYNSEAFAYNESTGEVSARTDYKGISLLFDLPLDRAKADRAKADAYLKELLREPSEDEPTDPASVDDAAEADLANKIEALKKKIPGGTVIPESIKEVTADDQGKIHYEYDDWTVTILLEELFVEGQTGISDAVSFSGDGRNYKALQFSKDENGVVTGKIIILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQI0</accession>
    <name>A0A398CQI0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_04470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04742">
        <property type="protein sequence ID" value="RIE04742"/>
        <property type="gene ID" value="D3H35_04470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="668" mass="75858" checksum="C8B60FA99582F4C8" modified="2018-12-05" version="1">MAVELRPLGVACNISCHYCYQNPQREAGNVPHSYDLERMKKAVEREGGPFTLFGGEALLIPIKDLEELFRWGQEKYGHTSLQTNGVLIDDERLALFKKYNVYVGVSIDGPDELNDLRWQINQERTRRSTERTIANIIRLCREHRPPGLIVTLHRINASAERLPRLHEWIRELDAHGIRSVRLHLLESETESIREKYGLTDEENVQALLGFAELQKELKNIRFDVLDEMERGLMGRDGATSCVWHACDPYSTMAVRGVEGNGQSSNCGRTNKDGIDFIKADKPGFERYTALYNTPQEEGGCKGCRFFLMCKGQCPGTAIDGDWRNRSELCEVWTQLFIHAEKQLIASGQVPLSIDPRRPRLERQMVALWKRGKNSSIQQLLKLQQPSLDDLPDCESMEKEASSLERFFRFAFVGESQRAVWAPRLTAIRSALARIEVLAVAKKMANAVIVHLEPAEVFQFHQYAAEHGLHCRLLNEGRRERWARLIVGSQEVVAAGERWTSNATESRLPQLPIMPICCRQANEERLRAGIIDPVWHAAASVGSDEEAVDQVDVKGRNALNPFLRPLGANLLGYQPCSFACEESRSVESAKLALGREAGLHEEMDWLEEMLQWPVEWKSLHGIAEVKTGILRYQYHTDYSSKALKIRYHGSSLASDAAQGLSFAYRRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQM6</accession>
    <name>A0A398CQM6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VWA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_05165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04855">
        <property type="protein sequence ID" value="RIE04855"/>
        <property type="gene ID" value="D3H35_05165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024163">
        <property type="entry name" value="Aerotolerance_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07584">
        <property type="entry name" value="BatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="101"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="664" mass="71561" checksum="65B498AB91364940" modified="2018-12-05" version="1">MTQQRHEGGGAVFFQSLASLWFALSLPLIALMYILKKKYTDTQIASSLLWRRTLREQEANRPWQRLRRQLLLAMQLLVAALLVLALTGPYLRGAAANGSRHIAVVLDNSASMTALTAEGGGTVFEQAKHTLRDWLSEQASSMSVTLLTTGADPEVVVSGQSNGKELLEAIDRIPLNFGNADVGASLSLADAILRNQTDGEIRLYTDGRLRSASLPATASPLKVVQLDGVANNTAIAGFGVRQLTNEDGQSAVVTLINRGASAQSGSLKVEAAAEADVDADNPYKLDYTLQPGEQRSYTVDKLTSAEYYRASIAASDGYAADNVAFAFPSSGGEERRALLVGHGNLFLDKALQLAGVKTVWADPERVEPDEELAKAIDWVILDGGDENKIRSLKGWERLLSSKPIWRIWSAESPPANGKAATPDSSGPVVRDHPVTRYLTFGETHISRLVKADSFGLGDSVVTYGGVPAIYAGKSDGKPGIVFAFDLHDSDLPLRSEFPILIGQAADWMSGGMTASLGQSVANERIDLQHHLSANSAEWVPVRIEDSYENENTNPKQAVRLESGSLSSEQPAPAVPGLYKYAEYDESKQLVASRLLSVVSAPEEGELRLNSDPANALPIGPSTTGTHDIDQKSADYRKSIIPWIAALLLLLMAAEWGVYRRGTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQW5</accession>
    <name>A0A398CQW5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_05505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04550">
        <property type="protein sequence ID" value="RIE04550"/>
        <property type="gene ID" value="D3H35_05505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07477">
        <property type="entry name" value="Peptidases_S8_Subtilisin_subset"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034202">
        <property type="entry name" value="Subtilisin_Carlsberg-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="157"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="411" mass="43822" checksum="C67AFCC97C286CC4" modified="2018-12-05" version="1">MTRSRKEENTRETVGAFAARLVQAKASERQAAKTNRRIARNSDYRKCLADLAKAGIRPVRKSDALRMICCHSKRSGHWKHLRRHPGIAYVEKDSRVKAHGLRLCGSSSGSAAIVRRKFGKRLPTRKAKYAAVASCPPKAPWNVCRVKSPPVWSATRGSGVRVGIIDTGIAKHPDLSIAGGVNTIARGRSYADDNGHGTHVAGIVAATGRARLLGNAPAVRLYAIKALDKNGEGYISDIVEGIEWGLKRGIRVMNMSFGMTENNRLLRDAIKRARRRGTIISASAGNSGKGAGTLDVPARYPETLAVAALTRKNRVASFSSRGRGIDLSAPGVSILSTWKNGKYRRESGTSMATPHVTGCAALLRAVSPAITATVAGRLMKASARRISGGSRAVGAGLLQASPAVRALSRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQX1</accession>
    <name>A0A398CQX1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLP-dependent aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_10240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03669">
        <property type="protein sequence ID" value="RIE03669"/>
        <property type="gene ID" value="D3H35_10240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="40"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="398" mass="44379" checksum="AE91FC892A13B5C5" modified="2018-12-05" version="1">MNYPFSARLGTFSSSAVREILKLTQSKSIISFAGGLPAEEHFPVDAVGEAFQRVLAAGNSALQYGLTEGYLPLRESICRRMKKKGVTVTPEAMLLTTGSQQAIDLFTRIMIDPGDVILVERPTYLSALQVFRSNGATAVSVDGDEDGLNLKDLEEKLEKYKPKIVYVIPTFSNPTGKAWSLERRKGVLELCRRAGAVILEDDPYGELRFGDDSLTYPSLFSLDQHPNGSCVVYTSTFSKTVAPALRTGWVMADPEIIRNMARAKQAADLHSSSLDQQTLYQLIEHYDLDGHIEFVRKEYEARMRQMAELLEQQQWPGVTWNEPKGGMFFWLELPEAVDTAELLKTAVELGVAFVPGGTFYAEDPQKNTMRLNFTHTDYEGTIVGMKRLSQALESVLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR74</accession>
    <name>A0A398CR74_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01931">
        <property type="protein sequence ID" value="RIE01931"/>
        <property type="gene ID" value="D3H35_14245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="16"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="109" mass="12511" checksum="B8F5AA8F395D3409" modified="2018-12-05" version="1">MDINTQFKKGALELCVLALIHKQDRYGYELAEAISEHVEVADGALYPLLRRLVNEGYCTTYLQESTEGPPRKYYRLTDTGASYTKELITAWNSFVRGVYNLIEKGDFHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR75</accession>
    <name>A0A398CR75_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_16550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic sulfate-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02327">
        <property type="protein sequence ID" value="RIE02327"/>
        <property type="gene ID" value="D3H35_16550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902358">
        <property type="term" value="P:sulfate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005669">
        <property type="entry name" value="Thiosulph/SO4-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30368">
        <property type="entry name" value="PTHR30368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0574">Periplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="152" mass="16603" checksum="15164CA243C324E4" modified="2018-12-05" version="1">MTDFHNRVKTLAKSDADAQKAFLDGNEGDVWVTTEQKALQLAESAGKGKIEIVVPSVTLTVEPIVSVVDRNADDKGIREVANAYTDYLFTEEAQTSAAKFGFRSRFASVAEQNAGKFPEVSLLTVDDNLTGWEDLQQALFSDSGLFKQLPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRH0</accession>
    <name>A0A398CRH0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF309 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04750">
        <property type="protein sequence ID" value="RIE04750"/>
        <property type="gene ID" value="D3H35_04515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005500">
        <property type="entry name" value="DUF309"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023203">
        <property type="entry name" value="TTHA0068_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03745">
        <property type="entry name" value="DUF309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140663">
        <property type="entry name" value="SSF140663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="212" mass="24731" checksum="1D57D9C3D9B76409" modified="2018-12-05" version="1">MVSVFFQDAGKEKLSYAGEAAHIRDWRHARSSAMNVSNIYPAPYLAYLSEYHGSRDYFECHEIMEEYWKERTGDPYSGCWLVFIRIAVACYHARRSNWSGALKMLNKAAAEIEPERMDELGLDGRRLSAMVHERAAEWADEDNRSYSDLDFPFADSSLEEECKRICERKGWKWRRDDHLSEDDLVHRHSRRDRSDVIEARQIAAAAKSQSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRI5</accession>
    <name>A0A398CRI5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FMN-dependent monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_02055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05175">
        <property type="protein sequence ID" value="RIE05175"/>
        <property type="gene ID" value="D3H35_02055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="145"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="217"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="443" mass="49392" checksum="B0F77E6ED777C7E7" modified="2018-12-05" version="1">MASQRQLKLGAMLHGVGTGWDNWKHPDAVTDAGTNFPFYARQIQKAEAGKFDFAFVADSVYITPKSTPHYLNRFEPLTVLSALAAVTSKIGLVGTLTVSYSEPFTVARQFASLDHISGGRAGWNVVTSFLEGTADNYSKDKHLDHDVRYRLADEYLEVTKGLWDSWEDDAFVRDKKAGVFYEPGKLHELNHKGEFFSVKGPLNIARSKQGQPVIFQAGTSEDGRNFAAKHASAIFVGHGNIEDAKLYYQDMKRRAASFGRAPEELLILPGISPIIGVTEEEAERRYQEKLGLVTIENALVALGRPFSYFDFSQYPLDEPFPDLGDIGLNSHKSFTEFIKKEAKEKNLTLRQVALAVATPRSIFTGTPVQVADIVQQWFEAGAADGFIISPENLPTSLEDFVEHVVPILQQRGLFRAEYEHDTLRGHLGLKIPENRYAKETVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRP7</accession>
    <name>A0A398CRP7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF4163 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_05125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04850">
        <property type="protein sequence ID" value="RIE04850"/>
        <property type="gene ID" value="D3H35_05125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021729">
        <property type="entry name" value="DUF3298"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025303">
        <property type="entry name" value="PdaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037126">
        <property type="entry name" value="PdaC/RsiV-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11738">
        <property type="entry name" value="DUF3298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13739">
        <property type="entry name" value="PdaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017306252" evidence="1">
        <location>
            <begin position="27"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="PdaC" evidence="4">
        <location>
            <begin position="54"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3298" evidence="3">
        <location>
            <begin position="180"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="2">
        <location>
            <begin position="270"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="356" mass="37912" checksum="1FA48E323E6DDE28" modified="2018-12-05" version="1">MKIRLRLVSTAIAGSLLLSAIPLASAQSATSAPVAASAKLADSLKAVTFTSKQIEEKNEAFEAKLQIPVASGLLDKKFEAKLNASIEEQAMNALAELKEQSATDKTEAEKDGYEFRPYYLDVSYELKSDGGSASKGVLSFTVTTYTYTGGAHGSAFVDTYNVSNGAAAQTLTLDKLLGAGAKEKANAAVREELRANPDNYYADSVKTFKSISADQTFYVSKGIVYVLFQQYDLAPYAAGIIEIPVRSALSLKPSKAGKAGSTGYYATTKGVRMVPLRAVASAFGYQVTWNGKASTVQLARGDKSTQIVLRKNSFSLNKSAPVKLSAAPSMLQGIVYVPADFLSRILELKVSISDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRS0</accession>
    <name>A0A398CRS0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05253">
        <property type="protein sequence ID" value="RIE05253"/>
        <property type="gene ID" value="D3H35_01655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="232"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="420" mass="46682" checksum="1C051E446BBA8064" modified="2018-12-05" version="1">MPFLRQDAGVGRGSLRGSLRRLRGGEERYPAFRIRLYEQEKLWAELRLVEVLMPKGQISRGDGRDRKAFLQEGVYIEGMGLSRHEGELTKLTETEVRGSDWFAGTVAAVYGVDHAASYRDLTRLAAIKDHVARIAEVHPSTVIPDESFRSASSSVYPYVRFPIAAEDLQGEFRVASKTPENDIEQAMAYWRRRLGSESWLGEDLYRAMIGSFVGRFVVQDPVQFEKASRGPVLYLANHQTAVESLLFACLAEGLTERPVAAIAKKEHRESWIGQLLSHMGAYPDARFPSPIIYVDRENQGSMLQTVKELADRMTEGKESILVHVEGTRALTEGQDVSVLSAVWPDLAIHANIPIVPVRFMGGLPEEAAATRLEFPVGYGKQDYLIGRPIFPDELRALPLPARKLIILDALNGTGAPARAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRS4</accession>
    <name>A0A398CRS4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000013">
        <property type="protein sequence ID" value="RIE05295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05295">
        <property type="protein sequence ID" value="RIE05295"/>
        <property type="gene ID" value="D3H35_01335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="98" mass="11071" checksum="636CD346A772D7A9" modified="2018-12-05" version="1">MGRRCSVFQLRLPRPDGVAVSRTPTRNGLNSSSEASYAPPSWHAVLRDRLQQLIVCHVGGQRLADAEMERLSKLDIRQAQAEMEWMAENLKFTVHLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS04</accession>
    <name>A0A398CS04_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00640</name>
        <name evidence="2" type="ORF">D3H35_00685</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05333">
        <property type="protein sequence ID" value="RIE05333"/>
        <property type="gene ID" value="D3H35_00640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05341">
        <property type="protein sequence ID" value="RIE05341"/>
        <property type="gene ID" value="D3H35_00685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="63" mass="7319" checksum="27BECD6907729E0C" modified="2018-12-05" version="1">MHQWLEWLVLLEMLEMLELLELLELLELLVLLELLCCSFGRQQLANQRYAAFTPKSIEGSKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS18</accession>
    <name>A0A398CS18_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplC</name>
        <name evidence="8" type="ORF">D3H35_02240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE04990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04990">
        <property type="protein sequence ID" value="RIE04990"/>
        <property type="gene ID" value="D3H35_02240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="208" mass="22499" checksum="B44DC53F27397B8D" modified="2018-12-05" version="1">MKGILGRKLGMTQIFAADGSVVPVTVIEATPSVVLQKKDEANDGYEAIQLGFADKREKLANKPETGHAKKAGTTPKRFIREIRGVNLAEVEVGQELKVDLFAEGEFVDVTGISRGKGTAGAIKRWGMSRGPMAHGSKYHRGNGSLATIRDANRVPKGKKMHGRLGSETVTVQNLEVVRVDLERNVLLIKGSVPGARNSYLKIRASVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS39</accession>
    <name>A0A398CS39_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_13200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01754">
        <property type="protein sequence ID" value="RIE01754"/>
        <property type="gene ID" value="D3H35_13200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="218" mass="24828" checksum="AD5DC191352763F4" modified="2018-12-05" version="1">MSFDVERFADLLKSAKGNRSINKYAQDIDISAAHISRLIRGLIGTPPSPETINKFAQGAHNGVSYNELMMAAGHIGKANVNEDGNADRETGSRLEKEFLHILLSELYQQDYEWSFEKSRGARFTPDFTIKLNNADYTVWHIELKSSTVIKDPYLYRLYGTIATLEMSPSVKFTIAVESLEAYNYIKDFPPVSLRANLFVMLVDFQKKAIVNEERLCRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS63</accession>
    <name>A0A398CS63_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_08980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04069">
        <property type="protein sequence ID" value="RIE04069"/>
        <property type="gene ID" value="D3H35_08980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="2">
        <location>
            <begin position="22"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="435" mass="47693" checksum="3BD194E2CFFF8A20" modified="2018-12-05" version="1">MVEEAVVISDRLQAAVSEVDSSMGQLEGIVNKSTEQEERLRRNGQFAMERLDEAFSALQEVAAASEEIRGTSTVLSDQSRQTRDIVVEVCRSLNQTDAVMNDLSVNHETMEARVRSLIEQASRIGEINALIQEIVAQTSLLAINAAIEAAHAGEHGLGFSVVASEIRLLAEQSGQAVKRSTAIVQNIEAGIREVVSSVDMEKRSVAQGMSEMGKNRERMDEIFNQIVKVDQRVGQTLDAAVEQARRTSATNEMLKGVVDSVGLTMESVDQLLVNNKRQRTEIVNLGRVSEEMKDSADELKAAVQKSGDRGWEQSVTMDAGKWIELLRALASDPSLNGLDEGVHRELLGTWMNRSPGMEAVWSNRSDGSFVFSEPEAGLLNARSREWWKRAMEGETYVSDVYISAITKRPCMTVSMPLTRPDGVAIGVVGIDIVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSA3</accession>
    <name>A0A398CSA3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04119">
        <property type="protein sequence ID" value="RIE04119"/>
        <property type="gene ID" value="D3H35_09260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="70" mass="7964" checksum="F13F3396FFC06F56" modified="2018-12-05" version="1">MRITITKSIFEKDWTVFNQTFPVYEILFLDDASSDNSVSLFREYARQPRKQTAIRAFVNSSIPAPSSSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSH5</accession>
    <name>A0A398CSH5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_01975</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05160">
        <property type="protein sequence ID" value="RIE05160"/>
        <property type="gene ID" value="D3H35_01975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="66"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="6">
        <location>
            <begin position="138"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="132"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE05160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="424" mass="45542" checksum="743333FDB2594C23" modified="2018-12-05" version="1">MTPKIGIVKKMVIGITAASAVTYGTSAFFLLVLKDSFSFLPGWLFVLLTLAFGIFWTGLFGFFAAKWLLRPLLALTRAAQEAAKGDLGVKVAASASNDEMQALGEAFERMLGQLRTIIAGIQDNSKLTDVHVKELQEAIGQAVGQIEQMTNESETITSGTQIQAESAERMRQDAEALSEAAGRMSSEAEAAKERTKHMNRAAVQSEEVFRSLVGGMHQLSELNRDAMDVVEKLNGYANQIGTISAVVGDIAEQTHLLALNASIEAARAGDEGKGFDVVAQAVKSLADESAVAVKNIRGLIGAIQAEVGRAVVHIRSQSEVSEREAKQGEAFAAAFHEVHQEAEQVSAIVESMADRMTAQARQATEQLEEARRVARVADQIRNGAQLVFSASQEQTAVMQEIAASTDSLRAKSTELRSKAAFFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSU6</accession>
    <name>A0A398CSU6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease Z</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04329">
        <property type="protein sequence ID" value="RIE04329"/>
        <property type="gene ID" value="D3H35_06940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="19"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="246" mass="27857" checksum="BD5E7ED2D84F9455" modified="2018-12-05" version="1">MGLKLRMIGTGSAFAKTFYNNNALLESGGQTLLLDCGITAPRALYEIGVSYDQLDAVLITHIHADHVGGLEELAFQMKFLYRRKPRLFVAEELIVPLWEHTLRGGLQQDGVGESLDAYFDVRPIAPNELFEPIPGLEAELIQTPHIPNKLSYSLLMKNSIFYTADMVHQPELLERLIEERGVRTIFHDCQLNPPGVVHASLSQLLTLPEAIQERIYLMHYGDDQPTFVGKTGRMTFVEQNRVYEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSW5</accession>
    <name>A0A398CSW5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">PTS glucose transporter subunit IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D3H35_07055</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04349">
        <property type="protein sequence ID" value="RIE04349"/>
        <property type="gene ID" value="D3H35_07055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00826">
        <property type="entry name" value="EIIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="15">
        <location>
            <begin position="1"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="14">
        <location>
            <begin position="386"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-1" evidence="13">
        <location>
            <begin position="487"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RIE04349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="628" mass="68795" checksum="B248FD693F317383" modified="2018-12-05" version="1">MLGVGYLQRLGRAMMLPLTVLPAAAIFLMLARLPWDAFGWPMAADMLHAAGMAIFGYVPYIFAVGVALGLSNQTAAAGMAALSGMFIFSIVTHTYDPDGVQPSMFAGAVIGVASGWAHDRFKSIRLPEFLQFFGGSRFVPLFMCGASFLFAWLMIGVGESIREWVSSAGTLAYTAGGFGVFLYGFLHRILVAFGLHHLLNHVFWFQVGEYKGADGTVYFGDLPRFFAGDPDAGGFMAGLYPTMMFALPAIAFAIIHEAREDLKPKTKRQFRVAALSSFLTGVTEPIEFAFLFVAPYLFIIHAIISGGIMWATYELGIHHGFTFSAGAIEYLINMPLATKGWLLLPIGVVVGIFYYILFRWSIRKFQLATPGREDAGRQDDWAGDIPYRAPLILQSLGGKENVVRLESCITRLRLTMDDDRRIDAQALRHLGAAGVIRLGGGHVQVVFGTYSELIREEIAKLMQQDVQQIQFHSPVQGRMIPLEEVDDPIFAKRLVGRGVAFIPEKGELVAPVKGTVIHVHPSLHAIGLRTDDGLEVLLHVGINTSQMGGKGFAALIKEGDTVTPGQPLLRFHLPTLKKHAKSLETPMVITNPEIVRSWRFAPFKAVKKGQAAVMSVVVHDKENKGVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT11</accession>
    <name>A0A398CT11_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03898">
        <property type="protein sequence ID" value="RIE03898"/>
        <property type="gene ID" value="D3H35_07980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025673">
        <property type="entry name" value="PCYCGC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13798">
        <property type="entry name" value="PCYCGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017360671" evidence="1">
        <location>
            <begin position="23"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="164" mass="17957" checksum="49436477219C6F1C" modified="2018-12-05" version="1">MKRRLFWLFTVAAFLFVAAACGKSAGGNSETHSEHAANGDLRETTASVQKLPAFLSDQRKEIQLAYQVAGTLSDTLQWIPCYCGCGESAGHKSNLSCFIHEIREDGTVVWDDHGTRCMTCLNIALQSAELSKQGKSHLEIRQYIDAQYGKGGFAKPTDTPMPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT45</accession>
    <name>A0A398CT45_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_20565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02997">
        <property type="protein sequence ID" value="RIE02997"/>
        <property type="gene ID" value="D3H35_20565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="SSF74853"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LTD" evidence="3">
        <location>
            <begin position="50"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="3">
        <location>
            <begin position="377"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="3">
        <location>
            <begin position="680"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="2038"/>
            <end position="2098"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="2099"/>
            <end position="2162"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="2165"/>
            <end position="2222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1819"/>
            <end position="1866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1819"/>
            <end position="1856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="2222" mass="239025" checksum="3B4A91322C6381E8" modified="2018-12-05" version="1">MIGMFHDQISKKREMKRKMKRVKRQASRFLTGLAAAALVATGVPGGSLLSFGQVHAEATESYPNLLITEIVFNSPNTGTPAADVNAWEYVELYNNGDTPVALGNYYIYRENYNSSTNYKWSLPSDKVLLPGQTIVARGTTVGDNGLLAAFNTAYALNPGLSEDQVATMDQSGGGNLPNTGTYTVSVKNVTDDQTVVSARYNDNAVNSTENGDDGNNKSVVYKYDPSGGTAMLKLASKQTPTPGTLVAGQIPPVAVPEPSPEPSPSPSASPDPVPAAKPAITYVPSVSTTTAKDLAVSAQVSSEAALTSVVLHYKKDGDASYASAPMTVGAAVDGVSTATGVIPQAVMTGTGKIQYYLEAENAAGIVRSPEAADAAYELNIEQAVPAPYLLITEIVFNSPNYNGGDVNAWEYVEVYNNSDKPIPLRNYRINYADLTGKTVRTWEFKDDKTIMPGKTMVLRAYSSDANGTLAKFNEIYKLSPALTDSDISDFTGEGNLENAPGRIVSIVTKSGETIVSASYNVAGSNADDLNNTSVTYRPDESGGLMMVKIGSKAAPTPGKLLAGQAPATPVQLPADFLSPIIEHKQSVGSTSVKELKISADVTDETAVQAVKLFYKTDKTSEFASVSMQLASGNRYEAVVPATVLDNVEHFYYYFEATDGFHTVSNPGASKKPYDIRVFNSVSSVTPDLLITELVPDNKGSDAYEYVEVYNNTSRTVNLKDYQIVYEFFHGSTIRWDIANDLLLPSKETAVVWVQSNLSMGKPVADFNAHWGVNLPDTKVAPLYALGMSNSDEGRILIAPDAANPVDHARNAISQAWYNVGEDEVNDDGASVVYEYPKDGSNKMYKRSAGMLATPGALIEGQVPETPVQVADDSAKPVISYQAPEGARLLDSITLSANVTDNKTVQHVTLMYKRNIDSEYRAANMIRSKTDPNQYVSETIAKKFLLGAASMDYYFEASDGQNVARTTDNGAAVYRMTFDQKSEPLWFDIQPGAFLRGTTTVQGNSQAAGQNLSLSVDETVLPSQKSPHEDAILSFRADDMQSAFKNGLIVNGELAGLLPDGKNLDPKYVVLPKSLLKPGENKILITAGNSISPTGTEGNNDDYRIENIEITLWNGMKQPIASARGKKLDTNAFTDINPEERQKVGDGSGYFEYLELTIDLPDSLFYGVSAKLDTTKLADGEHSFRLATASGASTVVNAIVDNTAPVFESFSIEEGKAYRGKIDFNATTKDEASGIASVTATLDGTAISLPAQANAVDLKPGAHVFLVTVKDKAGNDAVRSATFTIANEYPLLPSNPLPAFGATDVNRNATLSVNVTDPNGDPMDVTFRQAFRYDFNEQSDVKGYSNATDREPPLELTPTGETAFSGEAVTQVSRKDGTYFVTDADGLFPYQRYEFKLNENPQAIAEIEVVWEGHSLPDRQVTMYTWNYNTGKWVAAASGIGDKDFQLKAKVNAGDMVRNKTIHVLIQDLVPTAADGVDFTFAWASDTQYYADSYPEIFEKEMKYIADKKDEKKIAYAIHTGDLVDDWDRPDEWAVASRSMRFLEDAGIPYGVVTGNHDVNHAEGNYTEYWKYFGRDRFENQPTYGDDLNNNRDHFDLVSAKGQDFLIMYLGWNVQEETVKWANEVLKKYPNRYVIIGTHEYISPSGDYSGQGEKIWNEIVAPNDNVQMVLCGHLHGVAYNVKHVGERTVVEMLADYQSGPQGGLGYMRFLEFNLAEGKIHVSTYSAYLDDSNYFEEPGKDDFDLPYKTQNPSKQVATDYIGVNVYGSSVIGSKKAVASGKTATVSWSSLAANTTYYWYATAKDGNSEGTVSDIWKFSTGTSISGTNPGTNPETNPGTGTGTDTGSGTGTTPTTPGGSAVEISPKDIPESGSSVLLTIEKGTTTIALSADALAKIGDRPVTLQADGGAAVTLPASVIQALSGTLADGSRLTVSLGSVPQPIAGEAAQSYGAKLKAGMTIAGSTIDLVFGKQDSSGKTTAIDGAGKPVSIELTTGAVRNDRLAGIYRIDADGSAHWIGGSYSNGSYKANVEQAGMYVVMEYKKPYDDLAEGNWAYDYVQELSFKGIVSGVSDSSFGSDKATTRAEFIALIVRALGMKSSSSGGTSFRDVQAGSWYEEAVKAAVEAGIVSGVSETSFAPAKTITREQMAVMIVRALEYRKGSLGNTGSGASFADGDKISDWAKDSIGKAFNLGIIAGKENNAFDPAVSAKRSESAKVVYMLLQQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTB5</accession>
    <name>A0A398CTB5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DinB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04008">
        <property type="protein sequence ID" value="RIE04008"/>
        <property type="gene ID" value="D3H35_08620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="166" mass="18654" checksum="A9C3AD201EDF6F88" modified="2018-12-05" version="1">MSQSEIPVDIEAYLHTHEQLLDAIRGLNDEQLKWKAAPDKWSITEVLAHLADHNIVVSFRIREILSGSDVRLPAFRQDPWVEGQKANEGTAAEFLASFHALLVFNSLLFRRLGKENWKKTGVNFKDETVNLPIIIRAFIAHVQTHLSQIARIKQGSGESLGSSCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTK4</accession>
    <name>A0A398CTK4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_16355</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02294">
        <property type="protein sequence ID" value="RIE02294"/>
        <property type="gene ID" value="D3H35_16355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="345"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE02294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="552" mass="62742" checksum="E7B7AF04A0A7CF83" modified="2018-12-05" version="1">MLKETLLQLLIVLLPVFLVLVWYDRPERSKYVPFFIGMSCAVTMLLCMHFSIVFPESGLRYDLRHVPLIIGSLYGGFPAAVILSITYIAVRLAQMREPFEFILFAAFLAVVLPLIFSRIRSFGRGNRSKRLRITYWISCFVLVFMLISVSSHIDFTDGSSLSSAVVKIFVFGSIFFFSTAAGVHFIELGFDRVQLQTQLKDVSQQYRQETRRLQQFIDSTPLAVLFFDDRGTITHANDYIRDMLKIEGTEEFIGKRFSDLRHLLGGQINIDSIERVLNGEDRISEMIQSEGKVYFAETRSVKGPGRQSASNGVLFIGHDVSELQRLKEEVDRMERLSLVGQMAASITHEIRNPMAVIRGFLQLLGERSPSEQQTYFRIVMEELDRANGIINDFLSLAQNRIVQKEYGSLNEILQEVLPLIWADANMRGQIVELRMCEQVEKLELNSKEIKQLILNLARNGMEAMDDKGLLRIETLDLADTVQLRIIDNGVGIPEEKRERLFEPFFTTKTNGTGLGLSLCLSIIERHNGKIQVESLVGEGTTIIVSFCKPEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTL0</accession>
    <name>A0A398CTL0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02651">
        <property type="protein sequence ID" value="RIE02651"/>
        <property type="gene ID" value="D3H35_18405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="73" mass="8525" checksum="286DB2FF2F02B144" modified="2018-12-05" version="1">MSKALFWGVTIAIAFIVWYEWKNVRKLTSKDKAVFVSLLFAGWIMTFFDLPHMPGLVSFFDLLFKPLRPLAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTS1</accession>
    <name>A0A398CTS1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_09195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04108">
        <property type="protein sequence ID" value="RIE04108"/>
        <property type="gene ID" value="D3H35_09195"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="PTHR43078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="5"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="324" mass="36261" checksum="3D270790B119C756" modified="2018-12-05" version="1">MSKILVTGAAGFLGSHLAYQLIQKGHQIIGIDNLSSGRLDNVLPLMETGRFLFIPFDITSHHVLTLDALAGIEEIYHLASPASPKFYQSLPFGTIAVNTIGTSFMLELAKTNNAKIVYTSTSEAYGDPQVHPQQEDYRGNVNTWGPRACYDESKRLGEVYCYEYFHRYQVPVKVARIFNTYSAGLQNDDGRVISNFVTQALRQTEITVYGDGSQTRSFCYVDDTILALQLMMENDSANGEIINIGNPSDYSILEVAKLVQKLTRSSSPITFRPLPEDDPKLRRPVIDKAKKLLDWQPKVSLEEGLNRTIAVYRTQNTDKKGILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU07</accession>
    <name>A0A398CU07_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D3H35_19390</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02801">
        <property type="protein sequence ID" value="RIE02801"/>
        <property type="gene ID" value="D3H35_19390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="192"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="273"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE02801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="493" mass="55336" checksum="4608C3D2C559FAB8" modified="2018-12-05" version="1">MNGVGVSIKLKNSLFLAALLFLTVLVLSILVLNGISNHQRDSMEQELLTKTKTANISVKQAYLTTGSNDPQRFIRNRGQQLALDLALYSDLHVVLYDMNGKKAGDSLPQSSSEAIDGSLRYALKGKIAYQAQGESIFYLAPLQGPDSQMGVLQFEYSTAGDRLFHRTIAGLFVAAGAAVLAVSFALGYVYFKRSATSIAKLNRAVDRIREGEYPESRLLRRRDELGKLGQGITYMGLEIRRSMEAMKAEENKLRRALAKLEQLGAAQRQFIGNFSHEFKTPLTSIKAYVELMEMYPDDRDMQTDAVMRIGRETERLYEMVEKVLRLASLEKYDFEFHAQELEIREELLAIIDRMKAKANRFQVKIEEKLAPAHIWADRESLNHIFINLLDNAIKYNVPGGQAIVTGTVEDRRVVVEVKDTGIGIPEEARAHLFEPFYTVNKDRSRLTGGTGLGLSLVKVLVERHGGTIEWLESKTGTVFRVIFPLYTESGESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU91</accession>
    <name>A0A398CU91_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03417">
        <property type="protein sequence ID" value="RIE03417"/>
        <property type="gene ID" value="D3H35_12180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="174" mass="20797" checksum="36099B9B482F19EF" modified="2018-12-05" version="1">MPLEMEHVLPLYDCSKNPEIWANYPTKINSVEAMKSFVQKAIEGRERRDQFPFAVYDKELQEYVGSTRFLRISEENNNLNIGSTWYCPKVWRTRVNTETKYLMLKYAFEFLHTVRVEIITTTENTRSQKAIERLGAVKEGVLRKKYNNMDYVIYSITNDEWLDVRRRLEGYLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUG9</accession>
    <name>A0A398CUG9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02634">
        <property type="protein sequence ID" value="RIE02634"/>
        <property type="gene ID" value="D3H35_18305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045507">
        <property type="entry name" value="DUF6483"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20092">
        <property type="entry name" value="DUF6483"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="218" mass="24761" checksum="1463B883DC1D3DE2" modified="2018-12-05" version="1">MLERDFLMRMIAQSAKALGVIMGLREQKKPDEALVLVDDYLSRELRLKSRIAMGLSDDNLLKMLSVGDVVNGESVAVLSAFLQEEAELLSDLGRTEASVPRFEKALRLNLFLLKQNADPDNWDTRPRVDRLLASLDGYDWEPETYRAVMDWHEREGRYAEAENTLFELQNVSVASNEDGTSFYQRLALLTDEELEAGGLSRFELESGLREWNSLLKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUJ7</accession>
    <name>A0A398CUJ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MgtC/SapB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_18470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MgtC/SapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02664">
        <property type="protein sequence ID" value="RIE02664"/>
        <property type="gene ID" value="D3H35_18470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="232" mass="24909" checksum="7633794F45F07BC4" modified="2018-12-05" version="1">MRDPWMISNLDMVLRLMLSVLIGGLIGLERERKNHAAGLRTHILVCLGSCLIMILSMYGFADFADEANVRLDPARLAAQVITGIGFLGAGTIVITGRSISGLTTAASLWVVMAMGLSVGAGFYVPAGVAAVLVLLTLWGLNIVEKRFVRQRVEATLSLVLESQAPALESLQQLLADHGIKIVKIRLSDSDHDSDSIAARHVQLKVTLPKADQLLSVADYLRQVQGVVSVSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUL0</accession>
    <name>A0A398CUL0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MEKHLA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02674">
        <property type="protein sequence ID" value="RIE02674"/>
        <property type="gene ID" value="D3H35_18615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013978">
        <property type="entry name" value="MEKHLA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08670">
        <property type="entry name" value="MEKHLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEKHLA" evidence="1">
        <location>
            <begin position="11"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="154" mass="17450" checksum="FD16B44EC8402C93" modified="2018-12-05" version="1">MGRTFVVDLESHCRLLLSSYLRAVGKELIELKQGESSAAALDRAPFALLSHGAEADPVLNYGNKKALELWEADWEAFTSMPSRLTAEPMLREDRDRLLMEVREQGFSNGYVGVRISLSGRRFRIEETVIWNVVDEEGRFAGQAAMIPRWTELFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV79</accession>
    <name>A0A398CV79_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="9">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="9">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">fabH</name>
        <name evidence="12" type="ORF">D3H35_07695</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="9"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04458">
        <property type="protein sequence ID" value="RIE04458"/>
        <property type="gene ID" value="D3H35_07695"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="11">
        <location>
            <begin position="109"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="10">
        <location>
            <begin position="240"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="9">
        <location>
            <begin position="256"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE04458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="328" mass="35033" checksum="230A51D9E35F7F3A" modified="2018-12-05" version="1">MQSIPVGILGTGKYAPERRLTNEELAQTVDTNDEWIVTRTGIRERRIASPEQATSDLAYEASIRALEAAGITAEELDLIIVATITPDMFFPSTACLLQEKLGAKKAAAFDLSAACSGFIYGLANASGFIATGMYRHILVVGAECLSRITDYTDRNTCILFGDGAGAVVLGQVPEGRGFQAFKLGADGSGGELLRLCGGGSRMPSTEATIAERRHFIEMNGRDVFKFAVRVMGSAAEEALAIAGKSKNDIDLLIPHQANIRIIQSAIERLDLPEEKCMINLHKYGNMSAASIPLALAEAVEEGRVKDGDCLVFVGFGGGLTWGASVLIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVN4</accession>
    <name>A0A398CVN4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_03640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04598">
        <property type="protein sequence ID" value="RIE04598"/>
        <property type="gene ID" value="D3H35_03640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="97"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="97"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="223" mass="23708" checksum="981111D89B7C4135" modified="2018-12-05" version="1">MFTGLIEEIGTLRSVQRRGEAMIVTVAASKVLEGVKLGDSISVNGVCLTVVGFDGSTFSADVMPETFRHTNLQELKPGSPLNLERAMMAGGRFGGHIVQGHVDGTGTIVSRKAESNAVYFEVEPNRAELFRTIVPQGSVTLDGISLTVASVESEKGTFTVSVIPVTLKDTVLQFKSAGASVNIECDILGKYVDHWLTLRESPRAAARAGGLTAAVLRDNGFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW31</accession>
    <name>A0A398CW31_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2653 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04748">
        <property type="protein sequence ID" value="RIE04748"/>
        <property type="gene ID" value="D3H35_04505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020516">
        <property type="entry name" value="Uncharacterised_YxcD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10850">
        <property type="entry name" value="DUF2653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="93" mass="10774" checksum="A1A488CEC8093ED9" modified="2018-12-05" version="1">MRIGMDEIVNAVCLNLAERHEVPPTSVEVELLYDEEQGFSAEVWVQGRSRILIEANLKEAIMRYMLTQYNERVYPSQITLDVEDEIWADIESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX24</accession>
    <name>A0A398CX24_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03554">
        <property type="protein sequence ID" value="RIE03554"/>
        <property type="gene ID" value="D3H35_10975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="157" mass="18095" checksum="A13984D9971D0952" modified="2018-12-05" version="1">MSCLIRTAEDHELILVHRLMREAFEEYRDRLNPPSGALREEVEDIRNKIAGRGGAVIAWDGKEPLGSAQYYYEESYMYIGRVSVSGKARGRGIGQELMTCLENMARNRQVSEARIEVRLSLPGNIAFYEKRGYEVVEMLEYPNKTDAWYVMKKVLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXX8</accession>
    <name>A0A398CXX8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_09055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04081">
        <property type="protein sequence ID" value="RIE04081"/>
        <property type="gene ID" value="D3H35_09055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="35"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="398" mass="43478" checksum="21B35CDAC466A4C0" modified="2018-12-05" version="1">MNQQRWRSGRLDRLGSAIFSEVAEWKAAARADGLDVIALDIGSPDQPPAEEIRETLAAACMQPEAYRYPGTEGTGPFRETVARWFERRFGVGLDPANEILSLMGTQDGLAHLALAVTDPGDGALLPDPGYPVYGAGLAVAGVTPIPLPLDEQKGYLPDFDAVPQSVWDKVKFMILNYPSNPLSAVADLAFFERAVYAARRHGVLLVHDNAYSEMAFDGYRPPSVLEIPGSFEVAIEFHSLSKTFNLAGTRLGYAVGNRQVIANLRALKNNIDFGVFLGTQTAGIAAMERDMEGTLAPVSALYERRRDVFVGRLRNEGWDVPLPAATMFVWARIPEGWSSREFSRSLLKKTGVASIPGNAFGDRGEGYVRLALVEKEERLCEAADRIGAFLRSSEPNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY56</accession>
    <name>A0A398CY56_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000002">
        <property type="protein sequence ID" value="RIE05468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05468">
        <property type="protein sequence ID" value="RIE05468"/>
        <property type="gene ID" value="D3H35_00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="115" mass="12387" checksum="98FF45889F2AF2FE" modified="2018-12-05" version="1">MRPILMTAIATVCAMLPLVFGTSESGSIVSQSLAIVVIGGLIVATLLTRFSFAVHLRAAILPQVQTPARSKSQATNDRRLIAVRRKDCSARSEKTLRDGPSLAYEAGRRYSGKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYP2</accession>
    <name>A0A398CYP2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VanZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_07070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04351">
        <property type="protein sequence ID" value="RIE04351"/>
        <property type="gene ID" value="D3H35_07070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="40"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="128" mass="14425" checksum="4EBDEDDE2281CD4C" modified="2018-12-05" version="1">MAAIFYFSAQPGSELDGWLPFFRDWLPGLQSFDPMHYVAYFGLGLTVAFAFGAASARWRWALINVIVCSIYGVTDEWHQAYVPRRSPDIMDLYHDAIGAAAAALIVLIAIRIANRRHAKNYTERLGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D016</accession>
    <name>A0A398D016_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000004">
        <property type="protein sequence ID" value="RIE05457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05457">
        <property type="protein sequence ID" value="RIE05457"/>
        <property type="gene ID" value="D3H35_00390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="101" mass="11288" checksum="6B6753F1056D3BB4" modified="2018-12-05" version="1">MAIVVAASALFGLSKGYPMHLRRARRGAIPLSSLFVSAGCDIRDTAGRRTFAYRAVFAATRRGLVEVRSHIDRYLRSRVHGGLPKLYRLESSGRLWKRKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0J6</accession>
    <name>A0A398D0J6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Adenylate kinase</fullName>
            <shortName evidence="6">AK</shortName>
            <ecNumber evidence="6 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">adk</name>
        <name evidence="10" type="ORF">D3H35_02345</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6 8"/>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05011">
        <property type="protein sequence ID" value="RIE05011"/>
        <property type="gene ID" value="D3H35_02345"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADK_lid" evidence="9">
        <location>
            <begin position="127"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="6">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="126"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="136"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE05011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="214" mass="23325" checksum="E46A5CA444BEF9F6" modified="2018-12-05" version="1">MNILFMGPPGAGKGTQAERIVDTFGVPHISTGDAFRLAMKQGTPLGVKAKEFVDQGLLVPDEVTNGIVRDRLAEPDCSKGFLLDGFPRTLAQAEALDEMLADMGRKIDHVINLKVDRSFLLARLTGRRICKSCGSTYHVMFNPPKQDGVCDKCGGELYQRSDDTEEKVGTRLDEYSSKTAPLLAYYGDKGLLREVDGEKDIDAVTAEIGSLLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0U8</accession>
    <name>A0A398D0U8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_04800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04794">
        <property type="protein sequence ID" value="RIE04794"/>
        <property type="gene ID" value="D3H35_04800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="133"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="437" mass="45537" checksum="6306EEA13721A7DE" modified="2018-12-05" version="1">MARFEYRFPELGEGLHEGEIVKMHIAPGQTVTDEDIIMEVQNDKAIVEVPCPVNGKVLEVLAKDGQVMHVGEVVAIIEAEGEIPDQGPAAEAHGNAATGGADTKGEPAQAPAAAAQEAPAAAPAPAASNALVLATPSVRKLAREKGLNIAEVGGSGKNGRITKEDVLAYASGGAPKAEAQAPAAEGATAAASTKPASVSVSSGAGVEERVPFKGIRKAIANAMVKSMYTAPHVTLMDEVDVTALVALRNRAKPVAEKKGVKLTYLPFIVKALVAACREFPALNATIDEAANEIVYKKYYNIGIAADTDNGLVVPVVSDADRKNVWTIANEIRELAGRARDGKLAPADMKGGTITITNIGSAGGMFFTPVINFPEVAILGTGRISEKAVVKNGEIVIAPVMALSLSFDHRIIDGATAQNFVNYIKQLLSDPELLVMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D195</accession>
    <name>A0A398D195_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">(Fe-S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_03335</name>
        <name evidence="4" type="ORF">D3H35_03360</name>
        <name evidence="2" type="ORF">D3H35_26770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000018">
        <property type="protein sequence ID" value="RIE04941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000018">
        <property type="protein sequence ID" value="RIE04944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00796">
        <property type="protein sequence ID" value="RIE00796"/>
        <property type="gene ID" value="D3H35_26770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04941">
        <property type="protein sequence ID" value="RIE04941"/>
        <property type="gene ID" value="D3H35_03335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04944">
        <property type="protein sequence ID" value="RIE04944"/>
        <property type="gene ID" value="D3H35_03360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="131"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="242" mass="26639" checksum="91F43A0076937558" modified="2018-12-05" version="1">MKVSLFITCLSDAIYPRVGESMVRLLARHGIRLEFPTVQTCCGQPAFNSGYWEEARATARTILEAFEDSDFVISPSGSCTGMIHHYPKLFENDPVWLPKAEALQRKSFEFTQFLVQVLGLTDVGAVFPHKVTYHPSCHGSRLLGVKDEPMQLMGSVRGLELVPLPFAEDCCGFGGTFAVKMADISGAMVTEKGDHVLETEAEVLVGLDMACLMNIAGNLRYRNAPVRVMHLAELLEEGVSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1U5</accession>
    <name>A0A398D1U5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000002">
        <property type="protein sequence ID" value="RIE05471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05471">
        <property type="protein sequence ID" value="RIE05471"/>
        <property type="gene ID" value="D3H35_00135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="61" mass="6487" checksum="1823FE413AA1D3FE" modified="2018-12-05" version="1">MEQEGQDYVDMQMGNSADGATYGNVNSPTFVSYTVQMKDGADADKIIDAVKGSARITLAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBW1</accession>
    <name>A0A398CBW1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00646">
        <property type="protein sequence ID" value="RIE00646"/>
        <property type="gene ID" value="D3H35_27155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038728">
        <property type="entry name" value="YkvI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37814">
        <property type="entry name" value="PTHR37814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="347" mass="37846" checksum="DF0792BCA7197914" modified="2018-12-05" version="1">MKSWLRSAQVAFTFIGTVVGAGFASGKEVMQFFTRFGQWGPLLILLSTFFFVWIGAKVMLLAADLKARSYEDLNKHLFGDHAGRLISHVMLIVLLCVNAVMLAGAGTIFSEHLNLGYQSGLLITIAGCFLLLRNGIESIMVINSIVVPVMMAFTVLLVYDTLQEPGANRWLTLASDLSPWAAGLSPFLYAAFNLAMSQAVLVPLGTAIGDARTLRRGAWLGGIGIGILLLSGHMTLSARMPGISQFDIPMGGIARELGPWIHWIFVLLIFMEIFTTLVADTYGLTLQLNSRTGLAPWIITAALLSFCFVIGQFGFGTLLSTLYPTFGLFSLGWLFLISRDRALKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCD0</accession>
    <name>A0A398CCD0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_26355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00836">
        <property type="protein sequence ID" value="RIE00836"/>
        <property type="gene ID" value="D3H35_26355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="303" mass="32750" checksum="DF068008CDF1AD21" modified="2018-12-05" version="1">MTTSSLDLQAYLKRQKDIVEKALADALPSDWRIPQPLREAADYSLLAGGKRLRPIFVLAAADSVGGEAASARALSFAVAVEMIHTYSLIHDDLPAMDNDDFRRGRPTNHKVYGEAMAILAGDGLLTHAFHKAAEAAELGVPAERALAVVRELSRFAGVSGMVGGQADDMLGEQGITSLEQLENIHLHKTADLIAFSLRAGGHAAEASERQLEALGLFGRNVGLAFQIQDDILDLIGDETKLGKPVKSDERQEKVTYPYLLGLDESRSRVARLTGEAKDALAGAKLADPNRLMEIADYIMARDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCJ9</accession>
    <name>A0A398CCJ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_29025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00450">
        <property type="protein sequence ID" value="RIE00450"/>
        <property type="gene ID" value="D3H35_29025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="348" mass="36449" checksum="C378C46379A5E30F" modified="2018-12-05" version="1">MNPVAEEAPTLTTVKFRSRPWAATLILIGGIIALAFSIALSVSYGAADIKLSVVWQAVFSFDPAITDHQIIKELRLPRVLGGAMVGACFAVAGAIMQGMTRNPLADSGLLGLNAGAGFVLALCFAFFPGLPYMYLIMYSFLGAGVGAGLVYGIGAMAKGGLTPVRLVLAGAAISAMLGALSEGIALYFRIGQDLAFWYAGAVSGTKWFELKVMFPWVAAAISGAIILSRSITLLSLGEDIARGLGQRTALVKIGATAIVLVLAGTAVSVVGAVGFVGLLVPHAARYWVGVDYRWIIPCSSVLGSLLVVLADLAARMINPPYETPIGALIALIGVPFFLYLARKERREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDC0</accession>
    <name>A0A398CDC0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00415">
        <property type="protein sequence ID" value="RIE00415"/>
        <property type="gene ID" value="D3H35_28810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="PTHR42686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="326" mass="37354" checksum="62B9B0CD60F6D4DC" modified="2018-12-05" version="1">MQYNTFGKLGDRVSRLGYGAMGLGGEFGNFSENDLIRSVLTSLDKGVNLMDTARNYGDSERILGLALREWKGEKPFIASKVQSKDQNGWGGPVPVESAFPKGWLRESTEISLRQLGVETIDLMQLHQYWPHWDDVDYWMEELLQLKQEGKIRGIGISIPDHRHDMALSLVKSGAIDSVQTIFHIFDPLALDCLIPICQANNVAVIARCILDEGGLTGFLKPDTEFGEGDFRKTYFEYLPREIYIERVERLREAYIPKYAETLAELAIKFVLHHPAVTTALSSMHVTKYAEENIAAADLTPLTDEIFLEIRRYHRWVRNFYETKYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDF0</accession>
    <name>A0A398CDF0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_22680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01206">
        <property type="protein sequence ID" value="RIE01206"/>
        <property type="gene ID" value="D3H35_22680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="272" mass="29174" checksum="B812C8C809F98970" modified="2018-12-05" version="1">MSFNNRLSVRLTLVSAGSLSAAAGLELFLVPHNLLVGGMTGISVLFSYLTDMRLGVLLILLHLPLLLLLLSDQKRHPHTRLLGAAGIFVWSVATFALHPKPALIDQSLASAAAGGIVIGIGFGLVLRYGGFLDPVAAGAAKRALPRYVAAFGSYHAAINGILLLAGGIMFGWEAAMHSILALAFVWRMTVVALNGFPMTRTLRITTERSDEIGLALRSKFGKEVTILLSEPDDGGARKSMLCNVHRLEHSHIVRDIRALDPECELSVLPVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDH7</accession>
    <name>A0A398CDH7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="11">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">secA</name>
        <name evidence="15" type="ORF">D3H35_22855</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="11">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the SecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="11"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01236">
        <property type="protein sequence ID" value="RIE01236"/>
        <property type="gene ID" value="D3H35_22855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="14">
        <location>
            <begin position="1"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="89"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="416"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="105"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE01236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="764" mass="85750" checksum="F7013212CEA80388" modified="2018-12-05" version="1">MNLAVRLMRKFEDRDIQHKLEGYRDKAELIRKRNLEAWDEKRLQAESLRLKKEAKSGTPLDELLVDVYALVCEAAKRKLGLQPYDVQIMAAIALHEGFLIEQHTGEGKTLSAVMPAYLNALTGEGVHVLTFNDYLASRDADWMGPIYRFLGLTVNSVQAGMSLSEKREAYAADITYVTAKEAGFDYLRDTIALDEADTVHRPFHYVIVDEADSLLLDEARVPLVIASESISSDNDGIRFAAVARQLEQDKHYDFDEFKRNVYLNDAGAARAESLLGCGNLYESHNSHLLVSLNCALHAESLLNKDVDYIVRDGKIELIDEYTGRVAENRHLPDGLQAALLAKEGLQSKAGGKILGTIPLQHFLSLYPKICGMTATAHVSAMEFEEIYRLQVVQIPQNRPNIRIDHPHRIYTHKEAKLKALVQEISSVHATGRPILIGTSSVEESDMLAEALAVADVPCHVLNAKNDAKEAEIIAKAGEIGAVTVSTNMAGRGVDIRLGGGDPTQAEAVAKLGGLYVIGTHVHESVRIDDQLRGRSGRQGDPGASVFFVSLEDELILRFGIHKAIRNLRQDEALEESVLRSKIAHIQRIIMGQNFDIRQELNRYSDMVEEQRRILYEERLGILKGETPMGPSEQRVRLFYIDQFWADHLAYVSYIREDIHLTSLVNRNPIDEFHEQIIQAYEQIPAKINRESANMLVKLGGSNDPAKWEELGLKSPLSTWTYIINDQYNPYMQTPSSWNAGTIIAYWLRKILRRVFGLSKSFDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE07</accession>
    <name>A0A398CE07_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribbon-helix-helix protein, CopG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00943">
        <property type="protein sequence ID" value="RIE00943"/>
        <property type="gene ID" value="D3H35_25620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="93" mass="10762" checksum="AE65CB57FC01450A" modified="2018-12-05" version="1">MANLHNTKRIMISLPDHLLREVDFVVEKENTNRSEIIRQAMKQYLVERKKRAIRDSMQRGYLEMAKINLNMASEAFQAEVDADGTLDRLVSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE22</accession>
    <name>A0A398CE22_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA gyrase subunit B</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">gyrB</name>
        <name evidence="13" type="ORF">D3H35_23970</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01426">
        <property type="protein sequence ID" value="RIE01426"/>
        <property type="gene ID" value="D3H35_23970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="422"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="375"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE01426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="638" mass="71500" checksum="7AB13517DCD47F6D" modified="2018-12-05" version="1">MSVNSQHNTYDESQIQVLEGLEAVRKRPGMYIGSTSGRGLHHLVWEVVDNSIDEALAGYCDKIDVFVHEDNSITVIDNGRGIPVGIHPKLQKATLEVVMTVLHAGGKFGGEGYKVSGGLHGVGVSVVNALSEQVVVTVKRDGHIYQQEYRRGAPQYDVKEIGETTETGTQTRFKPDPDIFTETTVYEYDILIGRIRELAFLNKGIRITITDERSGVSDSFKYDGGINEFVKYLNRNREALHEQPIYVEGSKDHIACEIAMQYNDGYSENLYSFANNINTHEGGTHESGFKSALTRIINDYARKMGYVKDNESNLTGDDAREGLTAIISVKIPEPQFEGQTKTKLGNSEVRGIVESLLAEKLMEFMDENPAVARKVVEKSQQAARAREAAKKARELTRRKSALEVSSLPGKLADCSSKDASISELYIVEGDSAGGSAKQGRDRHFQAILPLRGKILNVEKARLDKILSNLEIRAIITALGTGISDDFDITKARYHKICIMTDADVDGAHIRTLLLTFFYRYMRKLIEEGYVYIAQPPLFKIERNKVIRYAQSEKERDEIIAQFGEGVKLSIQRYKGLGEMNASQLWETTMDPDSRTMLQVRIEDAMHADLIFDTLMGDNVEPRREFIQQHAKMVKNLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE51</accession>
    <name>A0A398CE51_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DJ-1/PfpI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_25390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00983">
        <property type="protein sequence ID" value="RIE00983"/>
        <property type="gene ID" value="D3H35_25390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="3"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="197" mass="21869" checksum="67529AAA95190E45" modified="2018-12-05" version="1">MSKRVLILTGDGAEVLEVYYPLYRVKEEGYEAVVASPKKKVLHTVCHDFVEGWDTYTEKPAHLLAADVSFADVEPADYDALIIPGGRAPEFIRNDPELPRILKHFLDADKPVGAICHGAQVFLALGDRSYFEGRTLTAYNACKLEVESLGATYASETLHVDGRLVSGHAWPDLPGFMREFLNLLRQTSNKELSSSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEB6</accession>
    <name>A0A398CEB6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_26715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00785">
        <property type="protein sequence ID" value="RIE00785"/>
        <property type="gene ID" value="D3H35_26715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="81"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="146"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="215" mass="23169" checksum="541BA97FE18B190A" modified="2018-12-05" version="1">MELTPRQLEIIERVKGHAPITGEQIAESLGISRPTIRSDLSVLVMLGYIDAKPKVGYFLGKQLSTDGKVKEKLMRLKVKDVMGRPVVIPEQATVNDAVISLFVENTGILAVTDSDGGLAGLVSLKDLLKVTLGNPNAASIPISMVMTRLPRVMTVTPEDTVWEAAKKLLDHQIGGMPVVKSSGNGGTDRRSRLEVVGRISKTTMTQALVELTSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEL7</accession>
    <name>A0A398CEL7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_21845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01070">
        <property type="protein sequence ID" value="RIE01070"/>
        <property type="gene ID" value="D3H35_21845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017241208" evidence="1">
        <location>
            <begin position="31"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="440" mass="48081" checksum="329B4E3296D13AF1" modified="2018-12-05" version="1">MRKMKIASMLLLLAGVSVIAACSSGGNGVAESGNASSGAAATGTGSGGATKTVKMLNFKVEIKDQLAAMIKEYEQLTPGVKIALETIGGGADSAAALRTKFSSGDQPDIFLNGGYKELDLWLEHLEDLSDQPWAEHVLPFAKEPMTKDGKLYGQPLNLEGYGFIYNKDLFKQAGITELPKTFDELEAAAAKLQAAGITPFVNGYGEWWVLGNHLANIGFAYQDNPDTFIAGLDQGTATFVDNEKFQQWVKLFDLTLKYGGKNSLQVDYNTQISEFATGKAAMTQQGNWTQVSLSETNPSLNIGLLPMPINNDAEAMDKLPVGVPYSWVVYNKSKVKDEAKAFLDWMVSSDIGKRYMTEEFKHIPAFDNITANNEILGQLAADIIAYSQANRTISWNWFKFPGGEATSHYFSDAMQGYVGGQLSKEAMLKEFLTKWNDLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF41</accession>
    <name>A0A398CF41_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidinol dehydrogenase</fullName>
            <shortName evidence="4">HDH</shortName>
            <ecNumber evidence="4">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 11" type="primary">hisD</name>
        <name evidence="11" type="ORF">D3H35_21475</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5 10">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01025">
        <property type="protein sequence ID" value="RIE01025"/>
        <property type="gene ID" value="D3H35_21475"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="1 4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 9" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="4 6">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4 6">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 8">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 8">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE01025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="429" mass="45796" checksum="230B2AAAF231FC97" modified="2018-12-05" version="1">MYKGPAQGFKLERENEYGTPAQNAAVAEIVEAVRREGDAALLRYTAAFDKTTLTPEELRVPQEEIQAAYEKVDAQFVEALRQAAANIRSFHEKQKRSTWVDVQPDGTMLGMVLRPLRRVGLYVPGGKAAYPSSVLMNVIPAKVAGVPEIVMVTPPATGGRQGIDPYILVAAAEAGVTEMYRVGGAQAVAALAYGTDSIPAVDKICGPGNIYVALAKRAVFGAVDIDSIAGPSEIVVLADDSADPGYIAADMLSQAEHDEMASAVLVTPSAKLADAVAAELERQLATLPRREIASKSMEQHGAIIVTQDMSEGVDVVNKLAPEHLEIMTEDPLELLGRIETAGAIFLGPYSAEAVGDYFAGPNHILPTNGTARFSSPLNVDDFLKKSSLIRYSKEALRRDAAGIALLARHEGLEGHARAVEIRLEGRDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFA1</accession>
    <name>A0A398CFA1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF5050 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_21930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01085">
        <property type="protein sequence ID" value="RIE01085"/>
        <property type="gene ID" value="D3H35_21930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032485">
        <property type="entry name" value="DUF5050"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16472">
        <property type="entry name" value="DUF5050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017258454" evidence="1">
        <location>
            <begin position="24"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5050" evidence="2">
        <location>
            <begin position="148"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="316" mass="35083" checksum="13B1B2A3AEB19DAE" modified="2018-12-05" version="1">MKKMLLGIVMALLLLNGSLPVTAAAGTNDQLFWTGSFDEPNWLGVNLTVVDGKKNETRRLYKGAATSLAVVGDWIYFLKQDPDSEVIMGNIVKMKKDGSKLTEVTKGNDIQQFYVEGQSIYFGGYDRNYNFQLGVMSLNGTGKKILLSKAQFWSYSAIKGFVFYVDMNKDSRLYRIKQNGSGKTAISAGKLEEYGSFALYGDTLYYAEIASKGTTKWYLSDLDGKNKKALASKGTLAPISYRDKWFYYEETVRTSKTTVRSLQKIKRDGTGKQAVSNLSPNDRFIGLAGAAFVYKAHDGTIYQIGQDGKITNPTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFL1</accession>
    <name>A0A398CFL1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FMN-dependent monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_22735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01215">
        <property type="protein sequence ID" value="RIE01215"/>
        <property type="gene ID" value="D3H35_22735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="147"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="219"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="452" mass="50558" checksum="8495C86B10E4A323" modified="2018-12-05" version="1">MTSNTERQLHLNLFIMSTGHHEASWRHPDARPEAATDFQYYRDLARTAERGKMDSVFIAAKYRLANTIENRVIPQLEAITLLSALAAATERIGLTGTASTTYNEPYTLARQFASLDHISGGRAGWNIVTSTGDATAHNFSRDRHPEHQERYDQGREFVEIAKRLWDGWAEDALVIDKASGVYANRSRILPADYEGRYFSVKGPLNLPRSPQTYPVLVQAGSSEEGRQFAAELAEVIFTAQSTMANSLAFCEDMRRRLKAFGRPSESLKLLPGFVPIIGDTEQDAKRKERELNELSVSAYGLRTMSDLLQIDLSLYPIDGLVPLKDLPDISEIRGLKSRFQLLTDLARRESLTIRELIIRTAGGRGHYTFAGTPSQIADELQRWLREGAADGFNLMPPLLPGGLDDFVDKVVPELQSRGIYRTEYTGRTLREHLGLPLPTGRQMAEVAPTARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFZ4</accession>
    <name>A0A398CFZ4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00832">
        <property type="protein sequence ID" value="RIE00832"/>
        <property type="gene ID" value="D3H35_27005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="130" mass="14413" checksum="7C658D17BE1BE5F7" modified="2018-12-05" version="1">MNILSLGGSWHDFFGCLIVDGEIKYAIEDERLSRLKHSVGLSDEMILNCNAAMYCLEAAGLQLKDIDLIMGNDTLHPGFTWKFRELFNKTRLINHHLAHASSAFYPSGFEDAAVLVIDGSGSRSTRKPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGG8</accession>
    <name>A0A398CGG8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_16480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02316">
        <property type="protein sequence ID" value="RIE02316"/>
        <property type="gene ID" value="D3H35_16480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="108"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="342" mass="37739" checksum="4CAB9C40A0A7BCCE" modified="2018-12-05" version="1">MTTLPISLPLAGAAPLATPSVPTERSFLHRASRIALYVSLSIVSLLVLLFVAFHAYIAWSLSHPKVASLAANPFSAKNLEYSDIIFASSDGSMNLDGWWVPSKDSRKTVVLSHGYGANREESWVPMYDLADFLHGLEYNVLMFDYGFASASHRMAATGGRLESLQLLGAIQYARDAGSDEIVVWGFSMGAGTALQAALRHAPVDAMILDSTFLPDENTIYHNMRNQISIPKYPSVDLIRWFFPIMSGGTKLDQIPAEEAQQTAFDFPIFLIHGTADEKAPVYLSENVAKAQKNPDSRLWVVPDALHEMIFRMHPEEYTARTTDFLSHVHAAYLAKAAQPHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH23</accession>
    <name>A0A398CH23_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1294 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02506">
        <property type="protein sequence ID" value="RIE02506"/>
        <property type="gene ID" value="D3H35_17605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010718">
        <property type="entry name" value="DUF1294"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06961">
        <property type="entry name" value="DUF1294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="90" mass="10004" checksum="9F5DF155D0CC7607" modified="2018-12-05" version="1">MTAIIAIYLLLANIIAYSLMTYDKKLAVKGRRRIPEKTLFGWAAAGGALGALTAMRLRRHKTKHASFVVGIPLLLVLNAFCVYFLLTIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH55</accession>
    <name>A0A398CH55_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01800">
        <property type="protein sequence ID" value="RIE01800"/>
        <property type="gene ID" value="D3H35_13465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="262" mass="29377" checksum="41A8FD01D5223F55" modified="2018-12-05" version="1">MKKYWEMMKSQIKVDTAYNAWYWAGTVSMILRMLIIYAFWHAVYENRTTIGEMPIDTMITYVVLAMALNNYMAGVGNQLAGNVRDGGVAVELMRPYNLLDKLVALDLGNKVSGTLREALPMMLVAYLFIGINAPNSWADFPLFIVSAALGILIGTQLDLVLGIAAFWLLYIWGLRVLRNAIFLFFSGALLPISMFPEWLQTVSNFLPFQWMVYVPVSIYTGKIAGIEAVYAIGIQIVWLAGIYAAIRLAWSFAIRKVTIFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHR7</accession>
    <name>A0A398CHR7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP synthase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_14575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01990">
        <property type="protein sequence ID" value="RIE01990"/>
        <property type="gene ID" value="D3H35_14575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005598">
        <property type="entry name" value="ATP_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03899">
        <property type="entry name" value="ATP-synt_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="137" mass="14901" checksum="933F369389A17418" modified="2018-12-05" version="1">MTDELPALMRKISRTTFFFLSLGCLGWVIYPAWKPVFGGYLIGAIGSLLGTWHLAWKTARIAEVAATGRRSRSGFGFLSRASIGLLAAIISVRMLEFNLPATVAGLFTAPLATLVLGLMSNRRRTSGHSSEERGEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHY3</accession>
    <name>A0A398CHY3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-layer homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02866">
        <property type="protein sequence ID" value="RIE02866"/>
        <property type="gene ID" value="D3H35_19780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="53"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="202"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="439" mass="49745" checksum="56A1E7D73A961454" modified="2018-12-05" version="1">MLLFLWFFCRAGFLYSKKRGCHDVKKGWFWVVVITFCLSVVQQAPVIAKAPEAVATFSDVSGKHWAKTQIDQAVRKGYVKGYADGTFKPDKSVTVAEFLAMLFLSFTETDSAGNVTWSQATLDRFPDHVRARMIDGYGYDFSQGKPWYKNYADYAKFFGLMKDEYEGRYNEPLTRERASRIVIRMDEEFHTAIVEEYADLGIPLMKDYKYIEDYLRNDAAKTLISGILSGYPDGTWKPKKAVSRAEAISVIERFNDETLRKPVRVNLTGVPYSVVPGYGYADPQIIIFANNEMKQVHDTLTNALSNYKGVTERFNDRLVYFENEERLNGYVQQVYYNNDSWNGNSPLDVLITATGNAYGLVIPKAQGRYERAAQPLDLLLGIVYKDKASEARKVIDGAMISFRAGKLSGFEKLIGKRSMRIDPSSSEAIIISIGGYADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHZ0</accession>
    <name>A0A398CHZ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DsbA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14315</name>
        <name evidence="3" type="ORF">D3H35_14380</name>
        <name evidence="4" type="ORF">D3H35_14400</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01944">
        <property type="protein sequence ID" value="RIE01944"/>
        <property type="gene ID" value="D3H35_14315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01955">
        <property type="protein sequence ID" value="RIE01955"/>
        <property type="gene ID" value="D3H35_14380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01958">
        <property type="protein sequence ID" value="RIE01958"/>
        <property type="gene ID" value="D3H35_14400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="214" mass="23497" checksum="93618FFF03A29A72" modified="2018-12-05" version="1">MKIDLYSDMVCPWCRIGKSNLYDALAQWEAATGETIPVTYHAYQLDPSLPPEGKPFKSHMGQKFGGEDKIAPMLARVTEAGAAVGVTFRFDNVTRMPNTVLAHRLTVIVPEDLRAEWVEAVMKAYFEDGLDIASLDVLLAIGNEIDGADTTDWVRRLESGEGNEEINRDFEMARGMGITGVPFFVVNGKFALSGAYPASQFLAAFRKIAQETGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI86</accession>
    <name>A0A398CI86_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000043">
        <property type="protein sequence ID" value="RIE00889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00889">
        <property type="protein sequence ID" value="RIE00889"/>
        <property type="gene ID" value="D3H35_25885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="139" mass="15755" checksum="4ED591776CDA9F9A" modified="2018-12-05" version="1">MNRHGYHLIVVHIDPDSPKLDILLEREVDGVFVLNAAAKTFYQISKRYGLGIPLIGIDTYNEDTLFHKLIPDFTAAIAKVAELLGRRPDFVVIDDYRDKKYVDTIKAATGLDQREHSRIRGRAALCESFWQGEADKPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI92</accession>
    <name>A0A398CI92_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_25330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00899">
        <property type="protein sequence ID" value="RIE00899"/>
        <property type="gene ID" value="D3H35_25330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="292"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="752" mass="82312" checksum="6D188D65F2659A81" modified="2018-12-05" version="1">MNGRRTCHNRRQRRDSGTVSVYFIMVTAAFVAFTSLLIDFSRVAAFRKQSELAAKAGVRSVLSSFDPDVYSKYGLFIRGGDPADELFRETVEGNGEIGDGEGLFRYLDAQWSGIGVTESRPLAEHGVFRRQTMEEMKYKAPINLTLELLARFRGIVPAVKDAASTVDVLERMRNAYDKREAALDGVLREQESAGISLPHAFGGLIPYPPVALSGVRTAGKAVDTADAALMYGDYVEKKREDTARDEARRLSEEDGNAPEESAGPIHSAAILAYEASMAKLTASLNAASTDFKEELDRRLDMASLKLEEAESYNAELSRLAEEASSLKGEYSGEDSGYDDPEAKLGADTISPLSDIRKSVTDLVLDGSFFSDYRSELEEQRSSGIAVSDSVYRVASAVAASIGTENDGQALKDEAANVQNDYNGFHLAYGSEGSIPDKRKKLLDGHRTGDNERRLQEDKANEARKSAAGWLGAIQSLQGSKEQRLGFEEAIKLYKANLEWNKTEEEHLERHSRDDASGERDEALEATEGWLNLLLSGVAEARDSIFFGEYVYERFSRFEPADLREALSGGNEGGSSLSLERMETEFILYGLTEPAANVAASYGELFAFRLAIRTMEGLIECRGFGHPLVILAAALAYGFSNALTDVVRLVEKGSVPLSKYAKADTAYGDYARFFLIAHGQPASAAARCIAVMERKLGLALTKAYTYVSGEGTASLKLWFFPGLLKLFGRSDSLGGTIRGNRYEVTFTADSSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIJ0</accession>
    <name>A0A398CIJ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3298/DUF4163 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_15760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02195">
        <property type="protein sequence ID" value="RIE02195"/>
        <property type="gene ID" value="D3H35_15760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021729">
        <property type="entry name" value="DUF3298"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025303">
        <property type="entry name" value="PdaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037126">
        <property type="entry name" value="PdaC/RsiV-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11738">
        <property type="entry name" value="DUF3298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13739">
        <property type="entry name" value="PdaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PdaC" evidence="2">
        <location>
            <begin position="20"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3298" evidence="1">
        <location>
            <begin position="114"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="203" mass="22806" checksum="0A9DB1B0A41A8F08" modified="2018-12-05" version="1">MNGQTVMLPIHVKKITAGSHVKVNIPIVVGGTTPKARQAMNKAIENKSTELMKQQGFPSEDIQEMDGTFEIKTNERGVLSLSLLNYVFTGGAHGNTIQKSLTFDADTGRSYKLSELFKPDSNYKQKLNAIIEAQIKARELPLLVPYPGISDDQDYYIADKSLVIYFQLYEIVPYAWGFPYFPISVFEIKDIIDENGPLGEMMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIJ2</accession>
    <name>A0A398CIJ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_13960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01882">
        <property type="protein sequence ID" value="RIE01882"/>
        <property type="gene ID" value="D3H35_13960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="83"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="310" mass="34803" checksum="1D0C6CBF827B9AA2" modified="2018-12-05" version="1">MKTNVLAVVGSPLRRWAKNQSPLYLMLLPGVVLLFLFSYWPMFGLIMAFTDFQPKKGFLGSPFVGLKWFEYLFYNSPDFSQVLLNTVVIALLKIAVGTFASIVFALLLNEVVGRWFKKTVQTITYLPNFLSWVVIGGMVVDLLSQQGIVNRIIHAFGFDDIPFLQSNHWFRTVIVASDVWKNFGFGAVLYLAAIAGINPELYEACVVDGGGKWRRMRHITLPGIVPTLIMLSTLNLGNILNAGQDQILILYNPLVYETGDILDTFAYRSGIVNVQYSFATAVGFFKSLVGLAFILMANRLSIRFASRRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIT0</accession>
    <name>A0A398CIT0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ORF">D3H35_14530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01982">
        <property type="protein sequence ID" value="RIE01982"/>
        <property type="gene ID" value="D3H35_14530"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="4"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="121"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="349"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE01982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="415" mass="44693" checksum="B1A08A6D2AE4EB8D" modified="2018-12-05" version="1">MEQLRKQDPEIVKAMNLELQRQRDNLELIASENIVSEAVLQAMGTVLTNKYAEGYPSKRFYGGCEHVDIVEDIARNRAKELFGAEHANVQPHSGAQANLAVYLATLQPGDTVLGMNLAHGGHLTHGSPVNASGLLYNFVAYGVDEETFTINYDEVRKAAFKHRPRLIVAGASAYPRTIDFEKLGQIAQDVGALFMVDMAHIAGLVAAGEHPSPVPHAHFVTTTTHKTLRGPRGGLILCRQPWAAAIDKAVFPGTQGGPLMHTIAAKAVALGEALQPSFKEYGRNVVANAKVLAEGLVAEGLNIVSGGTDNHLMLIDTRNLNITGRDAEHVLDSVGITVNKNAIPFDPTSPFVTSGVRVGTPAVTSRGMDTEAMKTIAKVIALTLKNPKDEAKLEEARGLVRDLSAQYPLYPNLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIW4</accession>
    <name>A0A398CIW4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ</fullName>
            <ecNumber evidence="9">4.2.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase</fullName>
            <shortName evidence="9">(3R)-hydroxymyristoyl-ACP dehydrase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Beta-hydroxyacyl-ACP dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">fabZ</name>
        <name evidence="10" type="ORF">D3H35_14755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the thioester dehydratase family. FabZ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.59" evidence="9"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02022">
        <property type="protein sequence ID" value="RIE02022"/>
        <property type="gene ID" value="D3H35_14755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008659">
        <property type="term" value="F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008693">
        <property type="term" value="F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047451">
        <property type="term" value="F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004317">
        <property type="term" value="F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00406">
        <property type="entry name" value="FabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010084">
        <property type="entry name" value="FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="PTHR30272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01750">
        <property type="entry name" value="fabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE02022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="145" mass="15692" checksum="1B94DDCC6DD2C808" modified="2018-12-05" version="1">MLDITQIQEIIPHRPPFLLIDRITELEPGKRAVGIKNVTMNEPHFVGHFPGYPVMPGVLIVEALAQVGSVAILALEENKGKLGFFAGIDQFRFRGQVKPGDTLVLELEITRLKGPIGKGRAVAKVGDAVVAEGELMFALSDPNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIW6</accession>
    <name>A0A398CIW6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sulfonate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_26850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00808">
        <property type="protein sequence ID" value="RIE00808"/>
        <property type="gene ID" value="D3H35_26850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010067">
        <property type="entry name" value="ABC_SsuA_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01728">
        <property type="entry name" value="SsuA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017183472" evidence="8">
        <location>
            <begin position="32"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="9">
        <location>
            <begin position="57"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE00808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="339" mass="36060" checksum="7062EB54904FCF30" modified="2018-12-05" version="1">MKRGKAVRSKFGVVTALALTMVVMLALSACGSSKENKGESSSPSKAAAGEASKASKVVRIGYQKYASINILKEHGGLEESLEKIGYKVEWTQFPGGPQLLEALNVGSIDLGNTGEAPPIFAQAAGTPLVYLANSPASPKAESILVLADSPIKTIADLKGKKVALNKGSNVHYLLVKLLEKAGVDYKDVQVTFLPPADARPAFESGSVDAWVIWEPFYSAAQLATKARVLADGEGVVNNYEYYLASRSFAEANPKAVDAFLEQLTQSDAWAKDHLSDVANLLSPALGIDVPSLEQALSHRGFGIAKITDDIIAGQQQIADTFFKLGLIQKEIKVSDAVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ53</accession>
    <name>A0A398CJ53_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">asd</name>
        <name evidence="14" type="ORF">D3H35_11665</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03336">
        <property type="protein sequence ID" value="RIE03336"/>
        <property type="gene ID" value="D3H35_11665"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="15"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="43"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="162"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE03336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="346" mass="37656" checksum="F6441A11E27622AA" modified="2018-12-05" version="1">MSTQTLFNVAVVGSTGAVGEQILKLLAERDFPIKSLKLLSSARSAGTKIAFKGQDITVEEAKPESFAGVDIALFSAGGDVSKALIPHAIEHGTVCIDNTNAYRMDPGTPLVVPEVNIDKVNEHKGVIANPNCSTIQMVAALKPLYDRFGISRIIVSTYQAVSGAGAKAINEMLRQSREVLEGNDPNPDILPVGSLPVKHQIAFNAIPQIDKFQENGFTLEEMKMIRETKKIMNDESLEVTATCVRIPVVYGHSESVYVELKQDFDLSEVKKLLAEAPGIELQDDPDNQVYPLATDAAGKNEVFVGRVRRDLSNPRALNLWIVSDNLLKGAAWNAVQIAEHIANTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ54</accession>
    <name>A0A398CJ54_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="8">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">IMP cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">purH</name>
        <name evidence="10" type="ORF">D3H35_16685</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="8"/>
    <dbReference type="EC" id="3.5.4.10" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02350">
        <property type="protein sequence ID" value="RIE02350"/>
        <property type="gene ID" value="D3H35_16685"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE02350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="515" mass="55702" checksum="490289EE89DEF843" modified="2018-12-05" version="1">MANRRALVSVSDKTGIVEFCRELAQLGVEVISTGGTKTLLEKENVPVIGISEVTGFPEILDGRVKTLHPAVHSGLLAVRDDAEHRKAMEELGLDYIDFVVVNLYPFKETISKPDVSYEDAIENIDIGGPTMLRSAAKNHAFVTVVVDAGDYANVLDEIRAGGDTTLETRKRLAAKVFRHTAAYDSLISEYFAKQLDDPLPEKLTVTYEKVQELRYGENPHQNAAFYRKPLASSGNITTAEQLHGKELSYNNINDANAALAIVKEFDEPAVVAVKHMNPCGVGIGRDIDEAYVKAYEADPTSIFGGIVAANRVIGAETAARLNDIFLEIVIAPDFTPEALEILKKKKNIRLMRMGEVASASERKSDWLVTSVEGGMLVQQSDVHSLSEADIQVVTDRKPTEEELKQLLFAWKVVKHVKSNAILLASDNMTVGVGAGQMNRVGAARIAIEQAGEKARGAVLASDAFFPMGDTLELAAQAGITAVIQPGGSIKDAESIAVANANGIAMVLTGVRHFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ64</accession>
    <name>A0A398CJ64_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_16735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02360">
        <property type="protein sequence ID" value="RIE02360"/>
        <property type="gene ID" value="D3H35_16735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017287568" evidence="2">
        <location>
            <begin position="28"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="332" mass="36079" checksum="CBBF4408D92C2688" modified="2018-12-05" version="1">MKRTTAALAAILLLSSTALLQACNSKASESKGAAPTEQASKSNAPETSKASAPEPSKKPAAAPNPLPSYMPENSTLLSKTNSVYRVKFDSAALNKEVRFNIYLPPNYDTAQTYPTLYLLHPLIGSENSVLSATGISASADKLIADGKVNPLIIVAPLLENSYGLNVTDEMAKSCSACTVGNYEDYLTKDLIGFVDGHFSTVKEKSGRYIGGFSAGGWAALYNAFTHPDLFSKVGGHSPYLPLDEWKEIYTTPELKKQRDPLLLAATADIKDLSVYLDSGEQDQYQGYISTEKLNGILQNKKVKSEYHHFPGGHNQEYWDSQSDNLLTFYAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJA6</accession>
    <name>A0A398CJA6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_15795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02202">
        <property type="protein sequence ID" value="RIE02202"/>
        <property type="gene ID" value="D3H35_15795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="4"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="144" mass="15658" checksum="F4938F7FC70AF3BE" modified="2018-12-05" version="1">MAFFQSILLAYDGSNTSKKAAAAAAQIAAVNRSKVEVVHVLERLKPVVTGEPAVYTPPGIDLIQDASQEILEQSFDLFPPEINPRLTLLRGVPGPTIIEHSKQIGADLIVIGHRGLNRMEEMFLGSVGQYVVRHSAMPVLVMKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK06</accession>
    <name>A0A398CK06_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SPFH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_17385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02472">
        <property type="protein sequence ID" value="RIE02472"/>
        <property type="gene ID" value="D3H35_17385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03408">
        <property type="entry name" value="SPFH_like_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033880">
        <property type="entry name" value="SPFH_YdjI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13421">
        <property type="entry name" value="Band_7_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Band_7_1" evidence="5">
        <location>
            <begin position="19"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="DZANK-type" evidence="4">
        <location>
            <begin position="304"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="381" mass="40858" checksum="0FE96CE43AE14FEC" modified="2018-12-05" version="1">MAIIDVIKFNGLANRDWLVYRFPGESFVFGTQLIVGEGQIAVFVKGGKAVDFFTAGTHTLSTSNIPLLQSIVNLPFGGRTPFTAEVFFINKTSKLDVLWGTSDPISLIDPKYAVRLRVRAFGQLGIRITDFRVFLTSLIGAVGDGDVVKYDTVISYFKGVIVTKMKTLIADIIINQKISVLEIAPRLEDISAYSKQQLSGEFERFGIEIVNFNLTSINFPDEDFETINRILEDKAAFDLIGDSRYNVMRSFDVMETAAGNEGGGSIAAAGIGLGLGAGAGVAVGQTFGQGIGEAMRPPATSAPCQKCGTPNAEGTKFCSNCGDKLAVVKLPCHSCAALVDERMKFCPECGSSLTKKKCPGCSKENPPGSKFCSDCGTKMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK48</accession>
    <name>A0A398CK48_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Histidinol-phosphatase</fullName>
            <shortName evidence="7">HolPase</shortName>
            <ecNumber evidence="4 7">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_18935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="4 7"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02725">
        <property type="protein sequence ID" value="RIE02725"/>
        <property type="gene ID" value="D3H35_18935"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="PTHR21039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="8">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="268" mass="30773" checksum="B4BA64F5DE303820" modified="2018-12-05" version="1">MMFDLHTHHERCGHAVGSLEDYIESAIANGLRVLGITDHSPYFFAKEDHPYPRLAMAKSEFPKYVEEIMLLKKKYEGRIELLVGIESDVFKEYADLYGEVYTRFPLDYVIGSIHFTSPFAIMRGLNWKAASDEERRSEIERVAELLHLSVRCGWVNIIGHMDRFNRGYPSFRQSIAPYLDSTLKMLAESGVAMEVNTGGFRKGSEDYYPSLDVVERAHYYGVDITFGSDAHHPDRVGDGGETVRAMLKNIGYKQWVIFKQRKPVYLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK57</accession>
    <name>A0A398CK57_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02735">
        <property type="protein sequence ID" value="RIE02735"/>
        <property type="gene ID" value="D3H35_18990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014197">
        <property type="entry name" value="Sporulation_prot_YunB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09560">
        <property type="entry name" value="Spore_YunB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="179" mass="19148" checksum="1EC555814C0A1AC3" modified="2018-12-05" version="1">MENEGRRKNFGLSHRLPRADEGYRAYGGGRGSGAKRTSKRTGAHTDRSRVEQPFVIVLRPSVSVKFHPATAVKVDVGTRQQNAGINMLLVEVYVRIRTEIAVVIPFDQAPESIQTDIPLSYALIVGDVPAYYYDSSGNPVGSDAARAPAITLPSKPEGGSFPSAETPTPKSAEAGTSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKJ1</accession>
    <name>A0A398CKJ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02820">
        <property type="protein sequence ID" value="RIE02820"/>
        <property type="gene ID" value="D3H35_19500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="138" mass="15504" checksum="741C79233A0DEEF3" modified="2018-12-05" version="1">MGVNGIPQEREDEREAAAREELKMSDFATEAERNTMNRERLTFPDSRSSKEAFTRLLDAVATEEAAISHLIHAQAGQIEAFTGSEGNYPTAPTNQQINDFQNGVTRMLELLVEKQKLLVRMVELSKRLMDESGDGYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL07</accession>
    <name>A0A398CL07_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01919">
        <property type="protein sequence ID" value="RIE01919"/>
        <property type="gene ID" value="D3H35_14160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="124" mass="14063" checksum="C7CE2F0DEE89A1A6" modified="2018-12-05" version="1">MRSAYLCRDRERFFKERRPGRVTLGSARFGNVEIGHLPRAKFDAQSAISLGYKPIEQGLDRELTGGLRLPEHLQLVAPGDSGIEIPWRESQRQNHCDGRHSREAANYAVDRFEASKGCPQKDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL59</accession>
    <name>A0A398CL59_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Potassium-transporting ATPase ATP-binding subunit</fullName>
            <ecNumber evidence="12">7.2.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP phosphohydrolase [potassium-transporting] B chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Potassium-binding and translocating subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Potassium-translocating ATPase B chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">kdpB</name>
        <name evidence="13" type="ORF">D3H35_15595</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.6" evidence="12"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03145">
        <property type="protein sequence ID" value="RIE03145"/>
        <property type="gene ID" value="D3H35_15595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02078">
        <property type="entry name" value="P-type_ATPase_K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00285">
        <property type="entry name" value="KdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01497">
        <property type="entry name" value="kdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="583"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="612"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="650"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="12">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="372"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE03145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="676" mass="71998" checksum="9747C2F4E4A5ACB0" modified="2018-12-05" version="1">MKKTRQSMLTPSIVRSAIKDSFVKLNPLTMMKNPVMFVVEIGTLIVLLMTVFPGYFHTEDDIGFNITVFLILLLTVLFANFAEALAEGRGKAQADSLKKTKKDITANKMVGNGIKLVSSAELRKGDIVVVAQGEMIPGDGEVISGLASVDESAITGESAPVIKEAGGDFSSVTGGTRVVSDRIVVRIAADPGESFLDRMISLVEGAKRQKTPNELALSTLLTSLTIIFLIVVVTLAPMADYLDIELQIPVLIALLVCLIPTTIGGLLSAIGIAGMDRVTQFNVLAMSGKAVEAAGDINTMILDKTGTITFGNRMASEFVAVGKESLRDTAGWAAVGSLRDETPEGRSVLELMKKQLLRYDESLAEGGEFIEFKAETRMSGIDLPDGRKVRKGAVDAVKKWVIAQGGEVPADLDAASDRIAREGGTPLAVAVDSRIYGLIYLKDTVKPGMSERFEQLRRMGIKTIMCTGDNPLTAATIAREAGVDDFIAESKPEDKIAVIRREQAEGKLVAMTGDGTNDAPALAQADVGLAMNSGTVAAKEAANMVDLDSDPSKIIEVVAIGKQLLMTRGALTTFSIANDIAKYFAIIPAMFILAIPEMNALNVMGLGSPQSAILSALIFNAIIIPLLIPLAMKGVAYKPMSASRLLGRNLVVYGLGGVIVPFIGIKLIDLFVHLWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLP9</accession>
    <name>A0A398CLP9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_26610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00767">
        <property type="protein sequence ID" value="RIE00767"/>
        <property type="gene ID" value="D3H35_26610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="172"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="284" mass="32413" checksum="556E1419EDD05C3D" modified="2018-12-05" version="1">MIRRVVPATPAEPLPLQLETIGLNPDQENLERPKGYPCFHWLQTLEGEGELRAKGQVWKMTERSGVLLAPGTPHRYEAKSARWRTGYVTFQGTLAPALVQALGWSDADRLQWTSGHDRVAERLERMLELAEAGNDPSGWQASAELYRFLTLLRTDARTDNRPSMSNRLERMQTLLEWLDKQFANPGLGLAEMAAKLGIGERQLNERFRELFGQTAYAYLIQLRLRKAKEWLPARPDWTVRRIGEAVGFRDSSHFVATFRQKEGMTPDAYRKLYGSGSMADRPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLQ8</accession>
    <name>A0A398CLQ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00777">
        <property type="protein sequence ID" value="RIE00777"/>
        <property type="gene ID" value="D3H35_26660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901575">
        <property type="term" value="P:organic substance catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="288"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="667" mass="75733" checksum="A799F2CAFF089A4F" modified="2018-12-05" version="1">MARHLVIGNGKMLINLDNTASIRDVYYPYVGQDNHVGGHKCRLGVWAEGKFAWLDDPEWQFHLGYIEDSLVTNVTARNERLGVELFLNDGIHQRDCIYMKRVVVRNLGDTPKDVRLFFHQDLMIDGNEVGDTAAFYPANRTVFHYKKSSYFMFNGRSDLGGIYQFSTGIKRFHSAEGTWRDAEDGELAGNAIAQGSVDSTISFRTIVSPGNEKTIYYWMSVGSDLEEVKRLDQYVHESHPEKLLSRIVIYWNHWLSRAGGRQGDLPPEVVRQFKHSLLIVRTQIDERGAILAANDSEILQYNRDHYSYMWPRDGALIADAMSLAGFHGTVASFFHFCARNLSPEGYLYHKYNPDGTVGSSWHPYVVNGVPRLPIQEDETALVLYALWKDYARHGEIELPQSLYSTLVRKAASFLCDYMEPTLGLPRPSYDLWEERYGIWTYTSASVYGGLMASAYFADLFGDYDRGDQYRLTAERIKQGILTHLWDEQTGRFARGLVWQEGQWVKDMTLESSVFGLFEFGVLPAEDDRVSRTMNAIAQGLLIKTDIGGIARYTNDYYFRISDEIDKVPGNPWIICTLWIANFQIETAKRVEDLDEPRRTLEKVAAAALPGGNLPEQLHPLDGSPLSVAPLTWSHATYVQTVCKYSHKKKQLLEASSAASSNLEKSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLW5</accession>
    <name>A0A398CLW5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_12280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03435">
        <property type="protein sequence ID" value="RIE03435"/>
        <property type="gene ID" value="D3H35_12280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017422750" description="Fibronectin type-III domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="448"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1237" mass="132168" checksum="8CC9CD003246A5CE" modified="2018-12-05" version="1">MGLFFICLSACQHRARGTAQAYAAKQSPHGRAIGKTEGTGLAADGARWNHLVRVYDERIPVVADNVRITPDGRYVAFINFEYVGSAGGGELHSKLVLYDRETGTIEELLKSVDAKEPVRFAMSSDARWFAYSGKTRLMGVEETQVYVYDRKRQEVELISKQPDGLPASGMSDNPSISADGRFVAYDSSAADIVAGDSDNFDVFVYDRESGLTEQISKAVTSEDPDEISSGNSERPSISADGKFVAFESSSSFLTEGDDNGNTDVFLFDRSERKAQLLSVTAAGSQSAEESGHASISANGEIVAFQSYAALADDDTNGMLDIYVYRQSNGSVERVSVAPDGTENDYDSFEPKVGADGAYVAYESSPDTEDFDESMIADLNSRSTSEVTISGTEEQLTLPLTDLALSGGAGVGAFNAGYTVVDPGTGEEFPMIGLFIASKIDGEAPTWPAGSKLESSEVKTDRATLTWTPASDAIGIKEYRIYANDELIAAVDGSKTSYTATELAPATEYLFRVEAVNEDDIASSGGPTIVLTTEADDRTFELAAVFDRVATGNLPYTNSVLTISSKAKTGRTITATIAYASWLDDAGERLPAARTVSETLKLNETAAGSGDYAAAFSVKEGISELTSVSAIMTGAAGGPIEKQAEGLPRAVSGNLKLAFDNPGEVSIDKARLTVVSPSRKNYKVVTLSGSGPVIVEGLAAASDYEVQLIAANGKLLASNSGVLIESGMSESLSMTVLQEAQFRFKVTDQDGKPVPGITIDVWDEAGSELLADYLSDANGLTSWTAVSDNLKKLTAKVHLEESNYEPLPDKAISLKPGDNEIPIALEHSAEGKLQGKVLNPEGKPVFNALVTATQTYKGKPVVKQSYTDLNGTYSLTLFAGEAAIQAAQSSYHYNSAEGLRAVVVKDETTTLDIPVKMFDKGMVVLQVHVKMIGGEWQGPIDMEQLAFRAQLNSKFGSRTSYYQNSISFQGQPGEHIEVCVSGVLHKSVTECKSILLDENANGVADIWIEEKGGLIEGQVAAQTGAWTYANLYEVDGDNLRHVGSESFRTSQFAIHAPKAGTYRLELNRRNSTTNKQETAFKQLVVKEQETLNVGTIALQPSSYFSHVTANGFIAQPIEASPGGTVNLRAFYRNSGEGAVADAILSIELPGGIRPVTDSSSRIPVKVNGTVGTATLKDRMLEIALGNLEQKASGTVTLQTKLDDNFSLGKAQLTARIEGTAGELRSASHWDMSSLTFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM01</accession>
    <name>A0A398CM01_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00671">
        <property type="protein sequence ID" value="RIE00671"/>
        <property type="gene ID" value="D3H35_27300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017249276" evidence="1">
        <location>
            <begin position="33"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="323" mass="32952" checksum="F30E2E68679296CE" modified="2018-12-05" version="1">MSRSIGRSISLLLAVVLVLGGAFAGLPGKASAAAVNTDFSGTLTNSTTFVRPVMPGDVANEQGSPNTGDYFSRTWFYASNQWTSGAVTVTHSNGTGNYTRNYLLASIVPSITGSYTLSSISAAIADSDTTMYLYQGGFDRLSPYQNLVVGNDDIDTDGANYLSSINSVTLTAGTTYFIVVTSFDVGITGNVNFRVSGPGSVSASAIDPGAVTANAANNSVNASPGTVTAGGAVTLTAVGDRQASAGSKNGDERYIPTSWTSTESGMTGTFSLSGGNYTSTYTTGTAGSYTVTATFTKQTWNGSSWVNSSATNTKTASVTATGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM43</accession>
    <name>A0A398CM43_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03515">
        <property type="protein sequence ID" value="RIE03515"/>
        <property type="gene ID" value="D3H35_12010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="135" mass="15981" checksum="D35C26034B0B6642" modified="2018-12-05" version="1">MEQETERLPKYIYETLAHFRYRIRKFIRFSEEAARAQGLTPQYHQLMLSIKGYPGRDYATPTELAERLQITQHACVELIQRCEELELVKKFPNPQDGRSVFIQVTEHGMTMLEALSEIHMQEVQRMGLLEFRPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM51</accession>
    <name>A0A398CM51_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YigZ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_10540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03723">
        <property type="protein sequence ID" value="RIE03723"/>
        <property type="gene ID" value="D3H35_10540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015796">
        <property type="entry name" value="Impact_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015269">
        <property type="entry name" value="UPF0029_Impact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="PTHR16301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09186">
        <property type="entry name" value="DUF1949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00257">
        <property type="entry name" value="IMPACT_YIGZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0029" evidence="2">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1949" evidence="3">
        <location>
            <begin position="140"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="209" mass="23334" checksum="A3D5D3577641CB4E" modified="2018-12-05" version="1">MLARFTTVKEFGMQEIVIKKSRFIGHAKPVETEEEAVAFIEELKKKYWNATHNCSAYVVGERDQWQKALDDGEPSGTAGKPILEVIKHRGLKNVAVVVTRYFGGIMLGAGGLVRAYTDGAVAGIDGAGTIVKVLRREVTIDVDYTWYGKLENVLRERGMRVEDVAFTDRVRVLCLPEEGEADRFRAWITDVTQGQANLETGEASYFVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CME3</accession>
    <name>A0A398CME3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DMT family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_26865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EamA transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00811">
        <property type="protein sequence ID" value="RIE00811"/>
        <property type="gene ID" value="D3H35_26865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="15"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="152"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="294" mass="31988" checksum="B4AF3207B20235FF" modified="2018-12-05" version="1">MKPASSPIAPWIPLLAGMIAISFAPILVRSSDAPVSVQGMYRMLFTLVLMLPFGAKSIREARAVSRKDWLLLIAAGFFLALHFLLWMASLNYTSIASSTIILALEPVFVMIGAYFAFREKTNLLAVIGMGIALSGVIVVSSGDTGISRDALFGDFLSFAGMLAVVANMLIAKRLLTRISSYLYSLVVFGVASLFFALYNVAEGIAMVGYPAKEWGVFLLLAIVPTVFGHLIFNWLLQYVKATTISIAVLAEPVGASLLGMMLFSEMVTLFQYVGGALVIAGLIFYLRYERRSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CME9</accession>
    <name>A0A398CME9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyl-accepting transducer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_05850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000026">
        <property type="protein sequence ID" value="RIE04526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04526">
        <property type="protein sequence ID" value="RIE04526"/>
        <property type="gene ID" value="D3H35_05850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="3">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="130" mass="14074" checksum="BE7B93A5B442DA17" modified="2018-12-05" version="1">MARTVESSVRDARELHEKSKSIRGMADAIAGIAYKTNLLALNASIEASRAGEQGKGFAVVAGEVRKLALQSNETAAVISSKVEEIRAVIEAVAKRIERGSSKFRAEPSSYARREARSKISSEALPTWKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMG3</accession>
    <name>A0A398CMG3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoid-structuring protein H-NS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03645">
        <property type="protein sequence ID" value="RIE03645"/>
        <property type="gene ID" value="D3H35_10110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="322" mass="36322" checksum="FEC6E5EC59B14B5D" modified="2018-12-05" version="1">MSEHSKYNHCKIVDCTVRDGGLVNNWDFSVPFVQDLYESLNEAGVEYMEIGYKNSAKLLKSDGSEGPWRFLNDDFLRKIIDKKKTKLSALVDIGRVDEADVLNRSESMLDLIRVATYARDTAKATELVSLFHDRGYETTINIMALSNVMDNELNESLAIINDSPVDIVYIVDSFGSLDPDDFRYLVEKFRRALKNKRLGVHTHNNMQLAFANTLTAAQLGVELLDASVYGMGRAAGNTPTELLLAKLTKPGYDLRPVLGMIEKHMLKLREKEEWGYLIPDMITGMLDEHPRSAMALRASADRDNFTGFYDKMMTPEVFGAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMI6</accession>
    <name>A0A398CMI6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_09730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03823">
        <property type="protein sequence ID" value="RIE03823"/>
        <property type="gene ID" value="D3H35_09730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015393">
        <property type="entry name" value="DUF1972"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09314">
        <property type="entry name" value="DUF1972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF1972" evidence="2">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="424" mass="49575" checksum="6800CF1E0D002E4F" modified="2018-12-05" version="1">MKNIFILGSKGIPARYGGFETFVDQLTSRRSDPEIRYHVACLAEWNAETEHNGARCFHVKVPKIGAARAVLYDLLSLRRTIRYIRSNGLTDNAVYILACRIGPFLFWYKKKLRKLGASLYVNPDGQEWKRSKWKPWIQRYWKRSERLMIKHADRVVCDSKGIENYINREYAEYRPDTVYLSYGADLTPSKLGDNSEPIQEWFARHTIQEGGYYLMVGRFVPENNYELVLKQFMSSNTERTLVIVSNVTQNRFYEQLRDKTGFERDPRVKFVGTVYDQELLKKIRELAYGYIHGHEVGGTNPSLLEAMASTSMNLLLDVVFNKEVGGNGALYFNKYAGSLKLLLEEADRMEEDAILALQRNARRRIERHYDWQEIVEKYEGVFQQTDPYERKERSDHERNRAGRRKRDEALSLDEVRLEATSTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMK2</accession>
    <name>A0A398CMK2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_17370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02469">
        <property type="protein sequence ID" value="RIE02469"/>
        <property type="gene ID" value="D3H35_17370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="32"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="219"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE02469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="382" mass="42146" checksum="24E3494BDDF05FD7" modified="2018-12-05" version="1">MTFNDLKLKPEILKALSKENYSAPTPIQEQAIPVVLSGRDLFGCAQTGTGKTAAFALPIIQLLSDQQRSSSRQRRIRSLILTPTRELAIQIFDNFKVYGQYIDLRCSVIVGGVSQKAQERELEHGADILIATPGRLIDLINQRLVDLQYVQILVLDEADRMLDMGFIHDVKKIIAKMPGKKQTLFFSATMPPEIAKLVKALLVNPAKVEITPASSTADRIEQCVYAVEKGNKQSLLNYLLRDKSIESALVFTRTKHGADRVVRGLAKVNISAQAIHGNKSQNSRQAALNNFKSGVTRVLVATDIAARGIDIDELSHVVNFNLPNIPETYVHRIGRTGRAGLSGIAISFCEAEEVPYLKDIEKTIGKTIPRVKDHPFEAVTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMR6</accession>
    <name>A0A398CMR6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-galactose-binding periplasmic protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-galactose/ D-glucose-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mglB</name>
        <name evidence="10" type="ORF">D3H35_17775</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02539">
        <property type="protein sequence ID" value="RIE02539"/>
        <property type="gene ID" value="D3H35_17775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01539">
        <property type="entry name" value="PBP1_GGBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044085">
        <property type="entry name" value="MglB-like_PBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017450275" description="D-galactose-binding periplasmic protein" evidence="8">
        <location>
            <begin position="30"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="9">
        <location>
            <begin position="42"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE02539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="347" mass="37255" checksum="B2617FDB73DB2925" modified="2018-12-05" version="1">MKKKWIPLVVVGALAVTALAACGKSDDKASESAGGDKGNSKIGVAIYKFDDTFMSGVRAAIEGAASGKATLDIVDSQNSQPTQNDKVDLFVSKKYGAMAINPVDRTAAGVIIDKAKDADIPVVFLNREPSADDMKKWDKVYYVGAKAEQSGTMEGELLAEYWKAHPEMDTNKDGVLQYIMLKGEPGHQDAELRTKFSIKAIEDAGIKVEKLAEDTAMWDRVKAQDKMQTFLSAHGSKIEAVLANNDDMALGAIEALKAAGYFKDGKFLPVVGVDATAPALQALSDGTLLGTVLNDAKNQGKATFELANVLSKGETPSKDNTGYDITDGKYVWIAYKKITKDNMNDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMT1</accession>
    <name>A0A398CMT1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gamma carbonic anhydrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04666">
        <property type="protein sequence ID" value="RIE04666"/>
        <property type="gene ID" value="D3H35_04030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="168" mass="17667" checksum="CE00DE1614C3D2A4" modified="2018-12-05" version="1">MLLPFMGVVPRLGTGVFVADGAKIVGDVEIGACSSIWFNAVLRGDLAPIIIGKESNIQDGVVGHVNRDQPLIIEDGVSVGHSAIVHGCRIGKGTLIGMGAIVLSGAEIGEYALVGAGSLITERQVIPPYTLCLGSPAKVVRELTERDLEQLKRTADSYVTKGKQYLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN09</accession>
    <name>A0A398CN09_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000060">
        <property type="protein sequence ID" value="RIE00304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00304">
        <property type="protein sequence ID" value="RIE00304"/>
        <property type="gene ID" value="D3H35_29360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="10"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="146" mass="16463" checksum="3D03B25BD113FD63" modified="2018-12-05" version="1">MRVVKVRKAAAEGRTWKLKPEVSFNYLGQFDQDVETGLFAGSRYGAGSLVSPNGERTSTLSINGMVLGGQLQLTIDYNGKAYEADTIEELAAGYKRHLEAIIEHCADRRETEKTPSDLSFKQLTIQELEEFEEEMEWLTILDSERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN50</accession>
    <name>A0A398CN50_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03905">
        <property type="protein sequence ID" value="RIE03905"/>
        <property type="gene ID" value="D3H35_08030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="353" mass="39662" checksum="63A5E34083985E55" modified="2018-12-05" version="1">MASSDKEPGMTREWSEGNDMLMVPVTELSEGDCLGRDIYSPDGRLMLKRGAELSPKLIDGIKRLGQQYVYIEMSSRHGAEGGTDWKSNMRSVTKYVLRQLHEALLSNAPLPIKALMGWADHISDTVYGETDLTLDWNQIIKEKADLIEHSLNVCMLSVLTAKALGYKYKELREIAIGSLLHDIGLVIPHNETLLLHHPVVGHDILRKIPEIPQASLQIVLQHHEQIDGHGFPHGIEAPHVHQLAQICGIASEFDYFMNGSLTERLPCEGIEFLMSKIDTAYSYVVVRAFLKVFQPYPIGTKVRLTGGINGVVWEQNKSNPCRPVVVLETSGTRFDLLERPTFRIEAIRTADYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNE7</accession>
    <name>A0A398CNE7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein jag</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_24025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01437">
        <property type="protein sequence ID" value="RIE01437"/>
        <property type="gene ID" value="D3H35_24025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02414">
        <property type="entry name" value="jag_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02644">
        <property type="entry name" value="R3H_jag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038008">
        <property type="entry name" value="Jag_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038247">
        <property type="entry name" value="Jag_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039247">
        <property type="entry name" value="KhpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032782">
        <property type="entry name" value="KhpB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034079">
        <property type="entry name" value="R3H_KhpB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35800">
        <property type="entry name" value="PTHR35800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14804">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01245">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="R3H" evidence="6">
        <location>
            <begin position="142"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="207" mass="23117" checksum="E784195EA4873412" modified="2018-12-05" version="1">MTKLVASGKSVEDAVRNGLAQLGVLEDRVKVAVLEQPSKGLFGLIGAKEARVELELLPEPDGVIEAIAFLSEVSSAMGLSVTVERLDELESVRLNVMGSDLGLLIGRRGQTLDSLQYLVNIVANRHSNRHLRIVLDAEQFRERRRHTLESLAERMASRVIRSRKEIVLEPMTSQERKIIHARLQGHSEVKTYSQGDEPNRRIVIAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNF1</accession>
    <name>A0A398CNF1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_09460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03770">
        <property type="protein sequence ID" value="RIE03770"/>
        <property type="gene ID" value="D3H35_09460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="194" mass="22238" checksum="D5303ED86E0884A0" modified="2018-12-05" version="1">MERKPPDRRKQVVEAANRSFSTFGYKATTMDQVAKLAGVGKGTIYTFFANKEELFGEIMGAMTRELRQVADETIVPGLSFVDNLMNVLNRLLDYRDRHELTVKLAQEVRDIGTPMAKEAMDALERAIVGYIARHVKIAVDEGEIKRCDENLTAYLMLKTYLAMTVESVHLREPMGKEQVLEHFRFYWMEGLAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNX0</accession>
    <name>A0A398CNX0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000051">
        <property type="protein sequence ID" value="RIE00614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00614">
        <property type="protein sequence ID" value="RIE00614"/>
        <property type="gene ID" value="D3H35_27530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="138" mass="16134" checksum="ED423C64EDC9C570" modified="2018-12-05" version="1">MSGLFKSLREPGIDLSRFVLSVDLIDPWFELRKIQVISRADYQEDDIASIHVTLEYGNQVKSVLLDSSASTFNLEWNSILDNGEVRRQAVYRYKVLFRHVDGTERRFRCNLPTLSNEATLWKSFQESCIPSSRSRFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNX4</accession>
    <name>A0A398CNX4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VWA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_20465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02979">
        <property type="protein sequence ID" value="RIE02979"/>
        <property type="gene ID" value="D3H35_20465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="389"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="562" mass="60576" checksum="D537B364C7392C57" modified="2018-12-05" version="1">MAKKSKFFLISFFLLVIVFALVYVGVNLTSNVGKSKTEVASEDAGKQLNNLYSDLSINTAAPVKGQIDLDPADIAESLPDISKFPITVNNTTDQFVEIFSSTEKSGTGVDGWLTETATAFNEAKIDVNGKPASVKIRNIASGTAADYIKSGKYVPDAYTPSNELWGEMVKANGVKTQLITKRLVGNVPGIVIAKAKYDALVDKYGAVNVKTVTEAIANNEFSMGYTDPFASSTGLNFLVTALNTFDSSNILGDKAVQEFEKFQANVPFIASTTIQMRDAAKSGRLDGFVLEYQTYVNAADLKSGYVFTPFGVRHDSPLYALGDLSPDKLAIINKFTEFVGQDSYQKAAQEKGFNQLEEYKSELAAVDGNLLSSAQKLWKEKKNGSKPIAAVFVTDVSGSMDGEPLNRLKESLLKGQKFLGKDNSIGLVSYSDDVTINLPIGKYDTNQQSMFVGAVNSLQAGGGTATFDGIIVALKMLQDELAVNPAVKPVIFVLSDGETNKGNSLKEIKGLIENYKVPIYTIGYNANIKALQSISSINEAASINADTDDVVYKIGNLFNVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNY7</accession>
    <name>A0A398CNY7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Site-2 protease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_09060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04082">
        <property type="protein sequence ID" value="RIE04082"/>
        <property type="gene ID" value="D3H35_09060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="9">
        <location>
            <begin position="71"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="364" mass="41192" checksum="FA23D5E0617D84F1" modified="2018-12-05" version="1">MAEPVRDTEQEQRQQRKTGAGRKSALGIGAALLVALSKLKTGAFLLLKLGKPIWMMAISVGAYAILYPWEFAIGLVLLLFVHELGHVWAAKRVGLPVSAPIFIPFLGAAIIMKRHPKDAKTEAYMALGGPLLGTVGAFACYAVGWWTDYHLWYALAYVGFLLNLINLMPMRPLDGGRIVGAVSRWLWAVGVAGGPFLIWYTKSPLFFLLWAWFVWEMYNRFFRQKRKKPKFLADGQYVAIVDPHLPEWYLKSGEHRRELPFTCYCRMDGEHVAEFHWEAMSYRGELPLSEPCLIHKMYVTNITEPNAAGSVQFTVRAEGERFLQETFYDVPMPVRVKIGVVYGGLIGVLVFLIWKMGEMGLKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP42</accession>
    <name>A0A398CP42_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oligoendopeptidase F</fullName>
            <ecNumber evidence="6">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pepF</name>
        <name evidence="10" type="ORF">D3H35_20970</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Has oligopeptidase activity and degrades a variety of small bioactive peptides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03059">
        <property type="protein sequence ID" value="RIE03059"/>
        <property type="gene ID" value="D3H35_20970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013647">
        <property type="entry name" value="OligopepF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042088">
        <property type="entry name" value="OligoPept_F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004438">
        <property type="entry name" value="Peptidase_M3B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08439">
        <property type="entry name" value="Peptidase_M3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00181">
        <property type="entry name" value="pepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017397149" description="Oligoendopeptidase F" evidence="7">
        <location>
            <begin position="26"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3_N" evidence="9">
        <location>
            <begin position="161"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="8">
        <location>
            <begin position="251"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="646" mass="73670" checksum="54EE4C2F62C39E1C" modified="2018-12-05" version="1">MKPYVQPAAVLAALSFLIASGHAPATTQPRAAVAVPVREHIPRRLSPSMSQVPKRSETPKEHRWVLEDLYANQAAWDAEYAKVKHLTKEIAGFQGKLKDAETIARCFALEDDLSLLAERLYVYANMSHHEDTAEPKFQALSEKSKKLSVEVNEALSFITPEILAFSEDELRKLIADPTLNKYKRTLEEMLREKPHILSKNEEALLAQVGNVSQAPSTIFSMMNNADMKFPKVKNDKGEEVELSHGRYIQFLESRNAEVRRDAFKAMYDTYGKWKNTLAATLSANVTKNLFYAKARHHSSALEMSLYGDNIPQSVYDNLIGTIHEHLPLMHRYMALRKKLLKVDELHMYDLFTPLVEEFDLDIPYEQATKTVYDSLAPLGDDYRKVLKEGFDNGWIDIYENEGKRSGAYSWGAFGTHPYVLLNHKDNLNSMFTLAHEMGHALHSYYSDGNNEYRDAQYTIFLAEVASTLNEALLMDYLLNKSTDPKEKMYLLTYYADQFRTTVFRQTMFAEFEKIIHAKAEEGEALTPQELSSIYYDLNLKYYGDGMVVDKDIEMEWARIPHFYTSFYVYKYATGFSAATSFAKQILDEGKPAVDRYLGFLKSGGSDYSINILKKAGVDMSSPEPIRQAMSVFEGLITEMEKLTDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP99</accession>
    <name>A0A398CP99_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="8">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glycyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="8">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">glyQ</name>
        <name evidence="9" type="ORF">D3H35_06225</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04212">
        <property type="protein sequence ID" value="RIE04212"/>
        <property type="gene ID" value="D3H35_06225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00733">
        <property type="entry name" value="GlyRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00254">
        <property type="entry name" value="Gly_tRNA_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006194">
        <property type="entry name" value="Gly-tRNA-synth_heterodimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002310">
        <property type="entry name" value="Gly-tRNA_ligase_asu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02091">
        <property type="entry name" value="tRNA-synt_2e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01044">
        <property type="entry name" value="TRNASYNTHGA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00388">
        <property type="entry name" value="glyQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50861">
        <property type="entry name" value="AA_TRNA_LIGASE_II_GLYAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="295" mass="34159" checksum="339DBFB830A1FE27" modified="2018-12-05" version="1">MNFQQMTLTLQQYWAKYNCIVVQPYDTEKGAGTMNPMTFLRTIGPEPWNVAYVEPSRRPADGRYGENPNRLYQHHQFQVIMKPSPDNIQEIYLDSLKALGIDPRHHDIRFVEDNWESPTLGAWGLGWEVWLDGMEVTQFTYFQQVGGIDCHPVAVEITYGMERLASYIQEKENVFDLEWVEGVSYGDVFKQPEYEHSKYTFEVSDAAMLFQLFSTYEAEAKRAMDQNLVFPAYDYVLKCSHTFNLLDARGAISVTERTGYITRVRNLARQVAATYLQERERLGFPLLKEGAVRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPS2</accession>
    <name>A0A398CPS2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="1">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_25735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MoeA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00964">
        <property type="protein sequence ID" value="RIE00964"/>
        <property type="gene ID" value="D3H35_25735"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="1" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="2">
        <location>
            <begin position="200"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="352" mass="37654" checksum="FE3B4BB10E70704D" modified="2018-12-05" version="1">MTGRGSSDSGAAEHTILSSSVLREVKVEDAIGTVLAHDLTQILPGSFKGRLFRKGHRVEAEDIPKLKDIGKEHLYVIELAESDLHEDDAALRMAAALSGTGTAFGEPHEGKVSVKSDRTGLACIAKEFVDGVNGLGEIALATVTNHRVVHAGEALAATRAIPLIVPESKVRKVEKLAAEYKQRHGEAPVSVRPLRKARAGLLTTGSEVYAGRIADKFGPAVRAKLEALGSEVAEQRFAPDDRQIIVKDIHYFLQQGYDMILVTGGMSVDPDDRTPGAIAEAGTDIVSYGTPMLPGSMLLFGYLRGIPIFGLPGCVMHDPYTSFDVLLPRVLAGDRIGKEDIVAMGYGGLHRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPW3</accession>
    <name>A0A398CPW3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_06330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04230">
        <property type="protein sequence ID" value="RIE04230"/>
        <property type="gene ID" value="D3H35_06330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="21"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="357"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="392"/>
            <end position="399"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="598" mass="66982" checksum="010081E48645DA61" modified="2018-12-05" version="1">MSDLVYFVRKLHVYVGAKLYVSIISAAALGFIEGIGLYFLIPMLNLLNGGRNEGENLPFLAPFLHMLTQLPNKAELPAILGVFVVLLLFQAVLQRIQQIQSSGISQTFIRALRLEFYEALLSAQWAFFMRRRSSDLQQLLTTELARAAQGALQVMAFAASIAFTLIQIALAMMLSFKLTIVIAACGLSFALFARRFVQDSKRLGERMTDLSQAYYASVSESFNGIKDLKSNRLELQHLTWFKSLNDRMRDNANRFVTVQSTSQLYYKFASAILIAAFVWIAFEWLHVKTGQLLVIVVIFSRLWPRFAGLQNLGEQIVSSLPAFRNLRTVQRETEAGREPNLYVEDAEEERMVVRTSIECHGVSFRHDPESPVYALRGVRVKFPAHRMTAIVGKSGAGKSTLIDIVTGLLRPESGEVKVDGQLLIEERLKSYRNAVGYVSQDPFLFHTTIRENLKVGSPNATDEQLREALSFAAADEFVQALPEGLDTVIGDRGVRLSGGERQRIVLARAILREPSVLVLDEATSALDNENEAKIQCTLERLRGRMTLIVIAHRLSTIRQADQVIVLDHGEVVQSGEYNQLSNESDGIFSQMLAYQKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPX6</accession>
    <name>A0A398CPX6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Succinate dehydrogenase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_19375</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02798">
        <property type="protein sequence ID" value="RIE02798"/>
        <property type="gene ID" value="D3H35_19375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011280">
        <property type="entry name" value="Succ_DH/Fum_Rdt_flav_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF53">
        <property type="entry name" value="PTHR11632:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01811">
        <property type="entry name" value="sdhA_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="10">
        <location>
            <begin position="6"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="11">
        <location>
            <begin position="452"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE02798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="585" mass="65300" checksum="2658043CE79EA208" modified="2018-12-05" version="1">MANNKVIVVGGGLAGLMATIKAAEAGTRVDLFSLVPVKRSHSVCAQGGINGAVNTKGEGDSTWEHFDDTVYGGDFLANQPPVKAMCDAAPGIIHLMDRMGVMFNRTPEGLLDFRRFGGTKYHRTAFAGATTGQQLLYALDEQVRRWEAAGLVQKFEHWEFTSVVLDDDNVCRGITAQDLRTMEMNTFKADAVILASGGPGIIFGKTTNSVINTGTAASAVYQQGVYYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRIWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFHVCVDEKLGVNGENMVYLDLSHKDPKELDVKLGGIIEIYEKFMGDDPRKIPMKIFPAVHYSMGGMWVDFNQMTNIPGLFACGECEYQYHGANRLGANSLLSAIYGGMVTGPKAIEYIKGLKKSAEDVSESVFSREASKQTAKYESILKMDGTENAYVIHKELGEWMTNNMTVVRYNDKLQQTIDKIKELKQRYTKININDTARWNNAGVAFTRQLWNMLQLSEAMTLGALMRDESRGAHYKPEFTERNDEKYLKTTKAKWTPEGPQISYEDVDVSLIKPRIRDYSTDKKKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPZ1</accession>
    <name>A0A398CPZ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01521">
        <property type="protein sequence ID" value="RIE01521"/>
        <property type="gene ID" value="D3H35_24525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="218" mass="24611" checksum="A3B0DF30E5627E4D" modified="2018-12-05" version="1">MDVDVYVEVDIKVDIDVDAGTSPKFSREMENMRERSFKLSDLSRAKGFRDFKTINSIAADVPGETNVVFPIEQEDFSSDTLASDTNLPSDEDHIDVLVESSKPRQAKPVNKPSVAPGPKLRPKKIAPQPVQQATWQEALEVERPATSHPGKIGGPKSASSPLKRKSLPFGDRYERITTYLEKPLYRRVHNLHQRGEFAKIANLFNAAVREYLDRYYPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ71</accession>
    <name>A0A398CQ71_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpC</name>
        <name evidence="15" type="ORF">D3H35_14615</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 12">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cell membrane</location>
            <topology evidence="2 11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01997">
        <property type="protein sequence ID" value="RIE01997"/>
        <property type="gene ID" value="D3H35_14615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036794">
        <property type="entry name" value="ATP_F1_dsu/esu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020547">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="PTHR13822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00401">
        <property type="entry name" value="ATP-synt_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46604">
        <property type="entry name" value="SSF46604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="14">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_DE" evidence="13">
        <location>
            <begin position="89"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE01997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="134" mass="14591" checksum="F53040CFDEBE7C74" modified="2018-12-05" version="1">MSTSTLRLEIVTPERKVYDGDVNMVVVKGVAGELGILPNHIPLVTPLKIAPVKAKKGGTEEFIAVHGGFVEVRKDKVVILAEIAEFGKDIDVVRARQAKERAEQRLNQKASDTDHRRAELALSRALSRLAAAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQF0</accession>
    <name>A0A398CQF0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02037">
        <property type="protein sequence ID" value="RIE02037"/>
        <property type="gene ID" value="D3H35_14835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032812">
        <property type="entry name" value="SbsA_Ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13205">
        <property type="entry name" value="Big_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Big_5" evidence="1">
        <location>
            <begin position="68"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Big_5" evidence="1">
        <location>
            <begin position="186"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="324" mass="35206" checksum="5BD5B41AE2829451" modified="2018-12-05" version="1">MSGMRNKSFVPKILHTRSRNIRYKTVHFQEDFFMTRFRAISLFLIVAILLQMGAVTVSPKSAAAASAGPILKSQSPANGSFITPDRGIRITFDENVRKGSGNIIFGSEVYPVATDDVHIQWETTKTILIKPTDLAVGQDYSVILEAGAFIGVTSGLPSAEYDLGTFSVRSLGVLDVFDETVASPYYPENGAVDIDADKSVALKLYFNQSGMKIGTGNVYIKKYTDNTIAQTIKTSTTATKISNATVGEVPVSFTSIPMSKLANSTKYYVMIDPGAFVDEYGNPFPGITNKEEWTFTTEELFDTVAPTASNFVFISSGASIPRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQK7</accession>
    <name>A0A398CQK7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03549">
        <property type="protein sequence ID" value="RIE03549"/>
        <property type="gene ID" value="D3H35_10925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="79"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="323" mass="36120" checksum="D974E6F635124B8D" modified="2018-12-05" version="1">MPPFGANPAGRRLFVREAATRCRAFLQMRAGVPMKQKRQIRIIALVCCIFAVQSTLFEAVAHSPEYEAVAPPSESNKYVLSLAHRGASGFAPENTLSAFDLAVRLKADYLELDVQMSKDGHLVVIHDTMVNRTTDGEGKVKNLTFDQLRSLDAGMWFDPFFAGERIPAFGEILDRYRGRIGMVIEIKQPELYPGIEEKIAGELAARGMHAPDGDSVIVQSFDLRALRHFHTLLPFVPLGLLISRASDSTDRRLDEFAKLVRFVNPVRNLVNESLIDRIHARGMSAFVWPIRKRKYVNGLIADGVDGLITDYPDVVTSARNGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQK9</accession>
    <name>A0A398CQK9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03088">
        <property type="protein sequence ID" value="RIE03088"/>
        <property type="gene ID" value="D3H35_21135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001539">
        <property type="entry name" value="Peptidase_U32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01136">
        <property type="entry name" value="Peptidase_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="123" mass="13889" checksum="4C2CCD20904FD913" modified="2018-12-05" version="1">MPLHPHRRGISRPAFPFRPETVLSALSPPESLAPICCKRHSCDESDDILLLEALPELYAAGSGQLYVEALLKTEEYNETVLRAYREAIDRLVANPDSYKFDERGLNRIRACSIGEGARFRIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQM0</accession>
    <name>A0A398CQM0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_05040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04833">
        <property type="protein sequence ID" value="RIE04833"/>
        <property type="gene ID" value="D3H35_05040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="7">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="224" mass="25835" checksum="9B3AA1724F9E7EE0" modified="2018-12-05" version="1">MTKILIVDDDPHIRELVAVFLVREGFEAIAAESGDEALRLLENALADLVILDIMMPGMDGWELCRELRRLYDMPLLMLTAKGETAQKVKGFQLGTDDYMVKPFEPIELIARVKALLKRYRIAISQQVTAGDLQLDRQTFQVTASEDRLTLPLKEFELLFKLASYPGKTFSREQLIEQIWGYDYEGDERTVDVHIKRLRERFPEERSGIRITTIRGLGYRLEALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQN1</accession>
    <name>A0A398CQN1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04470">
        <property type="protein sequence ID" value="RIE04470"/>
        <property type="gene ID" value="D3H35_07770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026286">
        <property type="entry name" value="MaiA/AMDase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267">
        <property type="entry name" value="PTHR40267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17645">
        <property type="entry name" value="Amdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="691" mass="74897" checksum="48212C049EFF5335" modified="2018-12-05" version="1">MKRAKAIWPEGMPKPAIPYSPAVRAGDWLFVSGQSASDLTTGLAPEAQVPDAFPHYQNAFRNQAAYLYGRTGQIADAAELPRGQVVRVNQWYRAEMDERYERGSLTVNNKRYVQEKKKFFGDYSPPSTGIGVRNLIVEGAKVEADFTARFASEGERPVPVSAPGLPKPASGYAEGVRLGHWVFLSGDLASDWKGNWGENGYEGELHSLAPEARSSGLYWGDEPVAKQTDYILGRLSKVAEAAGTRLGLAVKAYVYLADPADYVAFEDVWAAWFPDPFEAPARILVPNVEIGAKGCRVEIGMDLLMPEASSSRSAVRGGWMPKSKEPPAMRADDLVFFSGLMATGPEGLAKDAQNAPGLPYFDCPGRKQMAFVLEKAGKIADAAGVEIDQTVKATLYFTDLRYLAGAMQAWEAAFSGLCKPAITIVEINRELWVPGCVVMADLVLYDPRKGEPMARIGMLTPSSNTVLEPVTSKLTAELEGVTVHYSRIRVTAIKLGDDSDRQFSVDAMVEAAKLLADALVDVIVWNGTAGSWLGRDYDIELCRRIREETGIPATTSTLAFEEAYSALKARRIGLVTPYTVDVNERIVERYSLSGIGCAAHRCSGLHVNEQFANVGFEEIGSMIDQVAEAGADAVAVVCTNMNAASLAAAYEEKHGIPVLDSVSVTAWQALRLAAVDASSLANRWGGIFQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQX3</accession>
    <name>A0A398CQX3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_03190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04955">
        <property type="protein sequence ID" value="RIE04955"/>
        <property type="gene ID" value="D3H35_03190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="3">
        <location>
            <begin position="2"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="344"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="590" mass="65990" checksum="082A16112F755D6A" modified="2018-12-05" version="1">MGLLELEPERQVLLYDMHHIISDGVSMDILVREFVGLYGGQTLPAPRLQYKDYAVWQQAFMQSEAMKRQETYWLETFSGELPVLEMPTDYPRPAVQSFKGDQIQFVLDGELSAGLNRIAAETGTTLYMVLLAGYSALLSKYTGQEDIVVGTPIAGRPHADVENIIGMFVNTLAMRSRPAGEKTFTAYLQEVKEVALQAYEHQEYPFEELVEKLNVRRDLSRNPIFDTMFSLQNMSEEETEIEEMRFSPYGFEHSASKFDMSLTAVETGREIGLSLSYCTAIYTKETAERLGRHYVALLRDISSQTAKQLKAIELLSAEEKRQLLHAFNDTKASYPADQTIQGLFEEQVKKTPDHTAVVLESESLTYAELNGRANQLARVLRGKGVGADRIVGILAERSLEMIVGILGILKAGGAYLPIDPDYPAERIGYMLEDSGADILLTQKRLQGQTMGFAGEVLHVDDERLYALDNTDLDHTGSSKDLAYVIYTSGSTGKPKGVMIEQDGVINALLWRKQAYGFNETHSVLQLFSYSFDGFVTSFFTPILSGARAILLQDTRNPYAIVKAIATSKVSHFICVPSLFQAIQEYLSHRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQY5</accession>
    <name>A0A398CQY5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01841">
        <property type="protein sequence ID" value="RIE01841"/>
        <property type="gene ID" value="D3H35_13710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="23"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="207" mass="21894" checksum="DE1DC881B258295D" modified="2018-12-05" version="1">MGTTIHIDPADQSERDNYKLLIGSVLPRPIAFVTTLSDEGTLNAAPFSYFNIVTANPPMVSISVQRSGGKRKDTALNAEARGEFVVHIADEGYVAQLNETAASLPSDQSEVELAGLTPAASSKISVPGVAEPKIRMECVLERVITLGGTDDKGPACDLLIGRVVAFHIDAALYEGGRIDAGQLAPVSRLAGTSYAKLGDIFSIERPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRE8</accession>
    <name>A0A398CRE8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_03020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional repressor of xylose-utilizing enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05113">
        <property type="protein sequence ID" value="RIE05113"/>
        <property type="gene ID" value="D3H35_03020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0859">Xylose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="340" mass="36658" checksum="7B965697694E1F31" modified="2018-12-05" version="1">MKQIGGNAIVIKEVNVNFVRKALKTQGRATKQQLAQATGLSIVTVGTVLRLLLLEGEVLEGEPISSSGGRPARQYEYNAEYALALLLFPHESNGTIKARSTVVNLMGALVFETDEPVETIDMPTLERIIDERIASYPSMRAIGLGLPGAEYDGKMIVSDYEALLGVSVTEHLRTRYGKPVIMENDVNAAVIGYGERTGAGEQSTIVYLFFPERYPPGAGILIQGKLYKGRGHYAGEVANIPLGVSWGDASLMNSFDELCEAIAKLTVAVSSVLDPNVVVLHGRLISQEHLCSIADKCGARLPKTAVPAIMLSNDFEADYLNGLIALTLATLEPTIVLSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRI0</accession>
    <name>A0A398CRI0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03388">
        <property type="protein sequence ID" value="RIE03388"/>
        <property type="gene ID" value="D3H35_11980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="90" mass="10906" checksum="81B2D4A2AD345B9F" modified="2018-12-05" version="1">MWLHSFFKRFIFTLMHYYQQIQHILLTVFVIGVVDYFFLYEISVYLFATMPMLAVELIPLGVLLVLAIIVWRAAKYVRRKMKDNKHYLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRI2</accession>
    <name>A0A398CRI2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SGNH/GDSL hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02031">
        <property type="protein sequence ID" value="RIE02031"/>
        <property type="gene ID" value="D3H35_14805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="336" mass="37838" checksum="A3B29458EAA91AD6" modified="2018-12-05" version="1">MSSFISNSKKLRKRLSWGLIGLVVLGAVAEIGVFRNLDFYGKAPYSFIGQLDVLDQSFKHAETSRITTAVFGDSQSIDALRPELMGSAGGRDPGTIFNFSVSGGKAFDIYHTYLKYESKLTGLQEAIVVVNEHQINSYRIDKGDMFRYYAGFNDRLAVMDRHNYGELMLGWVSKAFDLRTTWSSKIVDPYLKGTLSKPFKWKAGGLAAVTMVDPEHMTAAYAEDTAKRWFEEYDPEGLQTDSFEALLSALHNRGVRIVVLQIPRSAEFETAIRKLYPEERSQYERTISAIASKYDAEFHMMSNEGLPLSTYFRDTNHLNPKGAAIVSKSVAELWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRJ5</accession>
    <name>A0A398CRJ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_02105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05185">
        <property type="protein sequence ID" value="RIE05185"/>
        <property type="gene ID" value="D3H35_02105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="168"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="374"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="631" mass="70254" checksum="48033FD2754FC296" modified="2018-12-05" version="1">MDWEAHIERWSRAAVKLLDIRQLSVKNGTVPDRYAAPASFFVVITHGEARVSLSGTVYRTRSLHILHGGQDAELGFVPLGNDFSCFLILYKADCASPEDRESFHFSYSYTPYALLPLQEKCQTMYRLWQQATPMDKLQAQSAFLPFVYEVMRQIRTSATEDNRPNVVTEAIHYIHEHYRESITAEELAGIFGCSASYMSRLFKNQIGAGPIEYLIHVRINKAKQFLKRSEARIQEIAKSVGYADVYYFSRLFKKHAGCSPLQFRENNRQTVQHNPSSLLKSSIVSQKPISHNENESYYQLVGEGDTSMFRFSRPAFGAMMLLCTTLLLNACQTGSNSATPASQPASADASADSAAGETRIYKHLKGQTEIPVKPQRVVSLFHLGELMALGVKPVGSTTYILDNPLLSDISDIADVGVPPDAEKILSLEPDLIVTTAPFAEAVEGGYETLNRIAPTIVVEQYNDPVKDVEMFGDILGKQKEAQQWNEAFAVKIAEYKEKISPFIGADDTFSILNVRPGALFIYGDTNMGGNIIYKYLGLKPNEKVKTDVINGETWEISAEVIPEFIGTQLFLAVNEGAEKDLKDLEKLIQSSPAGKAGKIYNIDFKQFLPSDPIAVEKQLDIIANLLIEGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRP0</accession>
    <name>A0A398CRP0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01594">
        <property type="protein sequence ID" value="RIE01594"/>
        <property type="gene ID" value="D3H35_24940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="159"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="284" mass="31849" checksum="97A922EF9546B94E" modified="2018-12-05" version="1">MLIQRFPPSPILYPYIDGILVQEDFSQTNFANRNPVKVLPTSMTVIGIQYGQPMNRLENNAAVSMGSSGITGLHATVKEYVSTGAIGTIIIPFKPGGLSHFTKYPLHEFQNVDVSLELVFPGRSVREMEEKLIGASGAEERVGIVQQFLIAMLRSKEEDRLIALAARQIMIHQGALSIERLAAQLYMSKRTLERQFNALIGASPKRFASIVRFQHTIELRNAGYDYLDIVQACGYTDHAHFAKDFRAFAGCSPEQFFRSEVQPELKKSFNESEAASRSNQHLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRQ7</accession>
    <name>A0A398CRQ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02051">
        <property type="protein sequence ID" value="RIE02051"/>
        <property type="gene ID" value="D3H35_14905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="172" mass="19195" checksum="BFD61E4826A68F51" modified="2018-12-05" version="1">MLKFDGLSILLIGLIGTVGLGLAAFEQSGALDEFRHFLRSEERLLEAPALQREVGPDVQRIVIRTDGGGYWPIYADAVDARELSVSAFVRASFLPGERDPSWLASLLSEERVGDTLYVTVRRPPASNGLDEAPSRFDVRVVAPKDVKVEFHTLAHELELRNKPEKWEVPTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRV8</accession>
    <name>A0A398CRV8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03949">
        <property type="protein sequence ID" value="RIE03949"/>
        <property type="gene ID" value="D3H35_08285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="63" mass="6895" checksum="56D12C25A06C368F" modified="2018-12-05" version="1">MLCDAKRDAMANLAVSVPGSDPLFRATRRKAIFNRYVRLTYSSLTVPLARGHSLSFREAGAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS68</accession>
    <name>A0A398CS68_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_02655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EamA transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05050">
        <property type="protein sequence ID" value="RIE05050"/>
        <property type="gene ID" value="D3H35_02655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="10"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="171"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="315" mass="33223" checksum="A462318A5BB3E819" modified="2018-12-05" version="1">MNKKSTAIGAALLVLLGASSYGLLSPIFKLALESGAVTEDLTFAQIASGSAILWLAALVMRKTAFRGRDRAGSKEQKGGSAGWKDTLKLAAVGICGLSLTTVFYNQALAHLDASMAIVLLFQFTWITILLESIRYRKAPSKKERVAAAFVVLGTLLAVGLLENGVTRLDGLGVAYGLLSALTYSLFFFLTNMIRTKKDPIQGSAIMMTAGLVFVAALRSPAEFQWNDSLSVFGWGLLLGLLGSALPTICFNIGIPKLGGSLAAMLGAVELPVAVVVSAIVLGESFSWLQGIGVGLILAGIAASQGWGVRQNRRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS98</accession>
    <name>A0A398CS98_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000006">
        <property type="protein sequence ID" value="RIE05423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05423">
        <property type="protein sequence ID" value="RIE05423"/>
        <property type="gene ID" value="D3H35_00610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="148" mass="16267" checksum="7A42D3C38E793D5A" modified="2018-12-05" version="1">MFKITSRSHTEIAAQLQRFADGDFTAVASPVAAKRKNDSLLFTLRRSSNSLRTLLRLVFRSSRELGDRLDSVTQRSEIISGQAATVTNTIQEVTLGVQEAAENVQRMSEEIAVIHGNLQELQLHSDDISASSSTYRSTVEQGLEAMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSH2</accession>
    <name>A0A398CSH2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D3H35_00025</name>
        <name evidence="13" type="ORF">D3H35_08930</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000001">
        <property type="protein sequence ID" value="RIE05482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04061">
        <property type="protein sequence ID" value="RIE04061"/>
        <property type="gene ID" value="D3H35_08930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05482">
        <property type="protein sequence ID" value="RIE05482"/>
        <property type="gene ID" value="D3H35_00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="188"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="257"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE04061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE05482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="522" mass="57838" checksum="17C2B30282C11EA9" modified="2018-12-05" version="1">MSIRLRLTLWYSGLLAAVLIGFGLLIYSVVYNSTMSDIRGELAKLSANMRVQAKIFNGGLDLNAQVPQGFDANIYGIQLVNYTQDKSGKSIDKTNNLIRTNITFPVSDFSKVDPQAKGRFFSDTLGGTRFLIYETPLLTLDGNLVGMLQVGAYTEREESLFSFLRSILIFAGLFSIAAAFSLGMLVSRKALRPIGRVTEAAEQIQSGSELGLRIPRETPNDEIGRLTDTLNGMLARLEVAYNHLEESNTAQRRFVSDASHELRTPLTTIRGNVDLLEKIWTLPPEGSEGHAAHKLPEAERKTMSLEAISDIADEARRMSRLVNDLLSLARADAGYAMEMNTLSLRPLAEEAARRASFLPRHAEWIVGPFEALDGVWVKGNKDYLLQLLFILIENGFKYTPSGKVRLYASRSGNHVGLTVSDTGIGLAAEDLPHIFDRFYRADQSRGQTSGTGLGLSIAKWIADMHKAKLEVKSRTEEGTSFTLWLPTLNPRTVDFAQSGEYGIMEPSERPDFSNSESREDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTX2</accession>
    <name>A0A398CTX2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YafY family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_17050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02414">
        <property type="protein sequence ID" value="RIE02414"/>
        <property type="gene ID" value="D3H35_17050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_11" evidence="1">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="WYL" evidence="2">
        <location>
            <begin position="138"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="320" mass="36823" checksum="24D436E4D8766473" modified="2018-12-05" version="1">MPKNDNMLTILWMLNSGEKLTAKQISEKLEINIRTVYRYMDALCASGVPIISDTGHNGGYSLLHNFIKSPLLFSMDEKKTLLHAALFAKEAGYPLSEALENATSKLKMYSNQEQERLLSHHLAGFEVINRRGYPAVQPVLQELEHAVANEWSVEISYRNSHEEQSPYRVIDPYGVVNWNNKWYTIAFCHLRNEIRSFRVERILSITSTPFSFRRPNEFSARTFFMNNLLPDVAGKSGYISLIISGKAEALDDLCIHWFLEHHLQERTSTQAIFLLEEEALYTHVPLIILPYGKSIRVIEPQNLKNRLVAVASELMEYYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUJ1</accession>
    <name>A0A398CUJ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iron-hydroxamate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_20305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02951">
        <property type="protein sequence ID" value="RIE02951"/>
        <property type="gene ID" value="D3H35_20305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017425154" evidence="2">
        <location>
            <begin position="25"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="74"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="324" mass="35698" checksum="8F3ECBE3EA37B267" modified="2018-12-05" version="1">MKKLSVPFVLTLVLLLSACGGNQANKNNDASSPSAESSSTAPSASPSASAASESATFTYQSENGPVEVPTHPQRVVVLTRFLTGNVMILGVPLVGVDEMSKDNPNFAEKLKDAEAVSDESLEKIIELNPDLIIGLSDIKNIDKFKQIAPTVTYTYGKVDFKQQQLEVGKLLNKEKEAQAWVEDFDARTKKAGEEIKAKIGANATVSVIETFNKQLYVYGENFGRGTELLYGQFGLSMPEKVKEATKKDGYFAVSTEVLKDYSGDYVIFSKNADEDNTFQGTQSYKNIPAVKNQHVFEADAKTFYFNDPLSMEYQLEFFIQHFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUN4</accession>
    <name>A0A398CUN4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_20585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03001">
        <property type="protein sequence ID" value="RIE03001"/>
        <property type="gene ID" value="D3H35_20585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="307"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="580"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="595" mass="68035" checksum="D295022439349D54" modified="2018-12-05" version="1">MLNGWNTFSKTVLLIIIVLLPIGLIFGYTNQISVQVIKKELQEKALKRLSFFGAQLDNTVNQLSVMSIVLGRDPGVGTMGSAGSGPGAYERLQKQEDFIRKMSVLSATSSWPNRLTIYYPAIKQAISSDYYGIYDEAYLARMSRQPSGSWVYLDDRKEFAKLLWSPLLVKRSIKDAETIVEVRFSEVNLVSMLRDYSADEIGNTFFYKKGFEPIYDHDLGAQSTPLGLIAASLDKEPPDEPGYRVVRVGNDSYMVNIVYSESLGWYAVNYSPLKQVLEPITTSRNLFYASLLLMLLIGLLAAVFLFRQVQLPITMLLRGIKKIQTGEYAFRIRYKPRNEFDYLFLKFNQMSEEIQRLVETVHAENIRFRDAQLKHLQAQINPHFLSNSMFFIKNMIAVDDKEAATRMILNLASYYRYVTKLEHTMTTLREELELIDNYLVIQNLRLERFHYEIEVPESMYRLRVPRLFIQPVIENTMIHTVEKSGRYGIIEMSGRQKGGECLIIVDDNGADISDETIRKLRTKVERPVEEGEGFGLWNVHQRLRYQFGTEAGLQFSRSPLGGLRVAIYWKDSISGESAESTESGKDDDDAAAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUT0</accession>
    <name>A0A398CUT0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplM</name>
        <name evidence="5" type="ORF">D3H35_02395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05019">
        <property type="protein sequence ID" value="RIE05019"/>
        <property type="gene ID" value="D3H35_02395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="145" mass="16354" checksum="7AA76911DF510391" modified="2018-12-05" version="1">MRTTYMAKANEVERKWYVIDAEGKTLGRLASEAASLIRGKHKAEFTPHVDTGDFVVVINAEKIVLTGKKLQQKKYYTHSHYPGGLKTTTAGDLLNKFPERLIEFAVHGMLPKNKLGHQLKTKLKVYAGAEHPHQAQQPEVYELRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUX3</accession>
    <name>A0A398CUX3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_10230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03667">
        <property type="protein sequence ID" value="RIE03667"/>
        <property type="gene ID" value="D3H35_10230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="182" mass="20111" checksum="FBCA6F6C6176C769" modified="2018-12-05" version="1">MAERLVGRPAPDFNLETALGNGQEFGTAKLSDYKGKWLVFFFYPLDFTFVCPTEITALSDAADEFRKLNAEVLGVSVDSKHSHRAWINTAKNDNGLGQLNFPLAADITKQVARDYGVLIEEEGIALRGLFIIDPDGELKYQVVNHNDVGRSVEETFRVLQALQSGGLCPMNWKPGQGHLVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVL7</accession>
    <name>A0A398CVL7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05359">
        <property type="protein sequence ID" value="RIE05359"/>
        <property type="gene ID" value="D3H35_00795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="295" mass="33719" checksum="7E1B2E11FE397F22" modified="2018-12-05" version="1">MRASVAICTHNRAADLLEALLSLVQQRFKDQFEVIVVDNGSTDRTAQTVLEFRQTVRFPVHYIFEERLGLSVARNRAIREAKGEYVLFLDDDAVASADWIEGIVSVFDRDPRIGCVGGKIEPAWEGEAPHWLSPENRSLYTILDYADDIAEMRRPAIPFGANVAFRKSVFDTTAPFREDLGRVGGNLLSSEESELIERIRTRYSVYYSPHASVLHKIPRSRISRKWLLRRIYWQGVSRAVSSKRKGGLFLQSLLKVPIFVLLSIPILYDKRRVFRNVSRIAYNNGLISGVLRTYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVP9</accession>
    <name>A0A398CVP9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05389">
        <property type="protein sequence ID" value="RIE05389"/>
        <property type="gene ID" value="D3H35_00975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="104" mass="11599" checksum="A6FD6F319BDCE419" modified="2018-12-05" version="1">MRRIGENKEPPPEASRRPTPPFRASYRLRGLFVEQRPNNLGRYSSDDGTRQAGTRPVTTAPAATTAPSSMTAPRRIVAPARDPDIVPDDRFFLDLRPSKLVGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVZ8</accession>
    <name>A0A398CVZ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1027 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03194">
        <property type="protein sequence ID" value="RIE03194"/>
        <property type="gene ID" value="D3H35_19005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009370">
        <property type="entry name" value="YutD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038141">
        <property type="entry name" value="YutD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06265">
        <property type="entry name" value="DUF1027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="330" mass="34621" checksum="E4D5437153F7AC2F" modified="2018-12-05" version="1">MAGGNAYELVHEHKTAWNPEAFRERFSEVLERYDYIVGDWGYNQLRLKGFFKEGHSRSTKDSTIASLVDYINEYCNFGCAYFVLTKLDATALPPGTELTDLESAAASAAASEGAEPQAAEAAVAPTTGGILMRWPLKERPGGPVRTPSMSAVARAVAESAERRNANAGSQSGGRSSSDGRQSGYGGGNRQDGGNRQGGRSNGSYYQGQGDRRQGGGGGGGGQTSGGAGEGRGGKPSYQQQQRERGPRQQGGDRNVSSGGQPRPQQQERAVVEPPRAGEAAVGAPRGDAAKSGGGGRWGPSGKNRRRQRYGGKPNHQESSHSPEPGKPGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWP4</accession>
    <name>A0A398CWP4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_10595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000033">
        <property type="protein sequence ID" value="RIE03631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03631">
        <property type="protein sequence ID" value="RIE03631"/>
        <property type="gene ID" value="D3H35_10595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017411922" evidence="2">
        <location>
            <begin position="31"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="302" mass="34182" checksum="04D8F2309C2F1A40" modified="2018-12-05" version="1">MLKTSKKFGKSSAIMLATAMSFVLILSACGNDKNKTGGNEASPVPPSSESASPTASESSSPDTKLSDYNLTLFLPGTTPKDEQKVEAEINKYLKDKINATLDLRFVDWGQWDNKMNLAIASRDPMDIIFTAAWNGHAANVAKKAFLALNDPNGPKGNLIEQYGQDITATLPEQFLKGAKIDGLNYGIPSNKSWRSRRHHLSQRYRRRARSDGQNRSGQNDRRSRADSGRSESEKARYDPGFHARRRELQRSLFFQIRLPRRQHDRRRRHEGRHGYDGTGPLRPTALQRNVGDYPRFFQKRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWQ8</accession>
    <name>A0A398CWQ8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmC</name>
        <name evidence="6" type="ORF">D3H35_02280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE04998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04998">
        <property type="protein sequence ID" value="RIE04998"/>
        <property type="gene ID" value="D3H35_02280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="65" mass="7486" checksum="05A7C76A19F26F81" modified="2018-12-05" version="1">MKASEFRNLTSAELEQKVSGFKEELFNLRFQLATGQLDNPHRIGELRKEIARAKTILRERELGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWV7</accession>
    <name>A0A398CWV7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_06830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04317">
        <property type="protein sequence ID" value="RIE04317"/>
        <property type="gene ID" value="D3H35_06830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="40"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="76"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="260" mass="28991" checksum="5072C1D1631042D9" modified="2018-12-05" version="1">MLTWMRRNRSSAVEEAEKPVETGPGDSRSASDPAPAKPLLSVRNVERSFDVGGQKLRVLKGINLDLYPGQLVMLRGRSGSGKTTLMNMMGGLDVPTAGEIYFHGNPLHEWNDDKRTEVRRRDIGFIFQAYALMPLLSAYENVELSLRMANAPRSEWKNRVTSCLELVGLAKRMHHRPFELSGGEQQRVAIAKSMAHRPSLLLADEPTAELDSQMAAQVMAVFREIVAKENVTICMTTHDPTILEVADHVYEMVDGVFVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXJ5</accession>
    <name>A0A398CXJ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YlbF family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04497">
        <property type="protein sequence ID" value="RIE04497"/>
        <property type="gene ID" value="D3H35_07240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010368">
        <property type="entry name" value="Com_YlbF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023378">
        <property type="entry name" value="YheA/YmcA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06133">
        <property type="entry name" value="Com_YlbF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158622">
        <property type="entry name" value="SSF158622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="139" mass="15312" checksum="9CCE22ED79BADA11" modified="2018-12-05" version="1">MADLLSRAYELGDMIKQSAVAADYVYWKEVADKDEQVLAFKRLFAKAKDKFAECERFGRFHPDYNEALEQVYELQAQMDLLEPVLRFKAAEEALDELLHEVSLSIARAVSDTIKVPDNNPNPKGCGSGGSCSCGSGGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYZ7</accession>
    <name>A0A398CYZ7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Acyl carrier protein</fullName>
            <shortName evidence="7">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">acpP</name>
        <name evidence="11" type="ORF">D3H35_07710</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 9">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04461">
        <property type="protein sequence ID" value="RIE04461"/>
        <property type="gene ID" value="D3H35_07710"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 7 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7 8">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE04461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="77" mass="8635" checksum="C52CDBC2BB74E52B" modified="2018-12-05" version="1">MSDVYDRVKRIVIERLGVEEAEVTAEASFKDDLGADSLDVVELVMELEDEFDLEISDEDAEKITTVGEVVNYIQSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZQ9</accession>
    <name>A0A398CZQ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GHKL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_00720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05347">
        <property type="protein sequence ID" value="RIE05347"/>
        <property type="gene ID" value="D3H35_00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="230"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="441" mass="50053" checksum="9EC93A05DD089717" modified="2018-12-05" version="1">MIIIFTIVVALATIILWVNPRNLSLRWLSTSLYTVGFSALCYYVDSGLSYAPDLLINSMNFVADAAIAYSFGMFGVVYSGLFNRTYRDRLAMAGLLLFVMIWMLTPLASSRHINYEGYNGLPTVLFEALFLIMGVVLLIVAYLRENQPFKKIERMLTNLIVVPTMLWIWICYFCYLLGYDLWQYNYIAAISFLFLFVIIGAKKGVLGVKIRIEMLKADASLHILQGSSSFINHMIKNEVGKIDILLHQLRHNLQAYPEPGPAAESEEMIAMAADSVSHIQSMMNKINERVQTIEVNLQKNNVWPMMEQCLDRLEKTVGTDVIVKRNFKAVSDVYFDPVHMKEVIHNMVSNAVEAMDRRGVLTASLFETKKEVILTIQDTGKGISVELLSTIFDPFYSTKKMSNHYGLGLYYCKNVMAKHNGSIHVESTQGKGTSFYIRLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D103</accession>
    <name>A0A398D103_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_02035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05171">
        <property type="protein sequence ID" value="RIE05171"/>
        <property type="gene ID" value="D3H35_02035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="15"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="368"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="412"/>
            <end position="419"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="685" mass="75914" checksum="C4A4C76CBEDB6CFF" modified="2018-12-05" version="1">MNALPDKSATPLLDMKELSVEFKNKNGGSLQVVDKIGLQIGSGEIVCLIGESGSGKTIASLSVMRLIDYDNGRITHGDVLLDGQSLVGLSQREISELRGKKVAMVFQEPMTALDPVFTIGYQITEVIRRHKRTSKAKAKEEAISLLRKVGIPDPELRMKQHPNELSGGMRQRVMIAIALACGPELLIADEPTTALDVTIQAQILNLLRELRDEYNMSILLITHDLGIAAEIADRIAVMYTGKIVEQSTTRELFERPYHPYTEGLLRSIVTLDNDRDSPLYSIEGTIPSLSDLPSGCRFHPRCPYATERCAESEPPLVERDGREVACWHSDQVIGNAEAAASIGIVVTERSEEPESVNRVNEPSGEALLEVRSLKKYFPLAGGGLLPGSRRYVRAVDGVSFEIRKGETLGLVGESGCGKSTLGRVLLNLEKATDGEIRYEGEDLLNPRFRNWKAMRREMQIVFQDPYGSIDPRWKVGDIIGEPFWVHESLRGRAKREKVEEVMQLVGLNPAWYDRHPHEFSGGQRQRIGIARAIALHPKFIVADEAVSALDVSVQSQVINLMQNLQRRLGLTYLFIGHGLNIVRHISDRIGVMYLGKLVEVAPADELFRHPAHPYTFALISAIPVPDPSRKKAFVPIQGEMPSPSAPPSGCRFHTRCPAASARCRSEEPDLRQVGPDHWAACHEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D260</accession>
    <name>A0A398D260_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_02150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05194">
        <property type="protein sequence ID" value="RIE05194"/>
        <property type="gene ID" value="D3H35_02150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007391">
        <property type="entry name" value="Vancomycin_resist_VanW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04294">
        <property type="entry name" value="VanW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="308" mass="34175" checksum="7D66C2E4D7956093" modified="2018-12-05" version="1">MLRLLWIAGISLVLRQNAVPDELSIVNQGTTVAKVNRGDYSLPATPLIDPAKLDSLLDNVERQTFRLPRDAEIGNHGGIVAEQPGYRLDRAGFTHLFHIYFYGSGTSSMEVPLKLIYPKVDSELLAYLREKPIGHYVTYFNAGNKNRSRNIALAAKAINNQVVFPNETFSFNQIVGQRNEKKGYVRAPVIVRGELSEGIGGGICQVSSTLFNAVDRAGLLIVKRYSHSRHVPYVLPGRDATVSWGGPDFAFRNPYNQPILIRAFASGGRMFISIYSSEVIDYRPRAVPGTSKRLPEEISIETGSPKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D2I5</accession>
    <name>A0A398D2I5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05284">
        <property type="protein sequence ID" value="RIE05284"/>
        <property type="gene ID" value="D3H35_01835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="90" mass="10339" checksum="0E3847AF7BDB6F89" modified="2018-12-05" version="1">MSRRKRRLEPLPEKVFLEEVERPFLLLLLVLLSGEIDHFDFNSPVLHQLFERGVDAGADEIDLRLDAPLICVYTRSKSAVISTFRADASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D2J7</accession>
    <name>A0A398D2J7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000013">
        <property type="protein sequence ID" value="RIE05294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05294">
        <property type="protein sequence ID" value="RIE05294"/>
        <property type="gene ID" value="D3H35_01330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="242" mass="26637" checksum="2116C43D93E8FB68" modified="2018-12-05" version="1">MKGNIPVIPTPFVDGKIDYEGFENLIRHTSDFVEGYVIGGSTGESPHCRRGAHRDRPLFCQARAAHAHRDRPQSYESGRSRGNRRAAVEAGIRSALVPSPYYFPNSLESVKAYVRSLAERTGLQIVFYDNPVTTKTVYTAQQLIELAAAVPAIKAIKMTDHNMGKIRALKQQTSLAVFGGDDIICFRAFEAGVDGNMILSRRSSIRRNSRSVGICTGQASVKRALPSFPTRFCRSSICSVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCI4</accession>
    <name>A0A398CCI4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_28975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00443">
        <property type="protein sequence ID" value="RIE00443"/>
        <property type="gene ID" value="D3H35_28975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="2">
        <location>
            <begin position="120"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3_C" evidence="3">
        <location>
            <begin position="499"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="751" mass="82179" checksum="662ABC87C79E2B9A" modified="2018-12-05" version="1">MKTMGKKAAIRYARNERGPTLGYSEASGVRLLYEDGLAFKDLNKDGKLDRYEDWRLSPEERAKDLASKMTIEQIAGLMLYSSHQAIPGNLNWFPATYGGQFFEASGAAPGDLSDQQLSFVANDHIRHILITRIQDPATAALWNNNVQAYAESLGFGIPANNSSDPRHSSDTSKEFNAGAGGAISMWPESMGLAAAFDPAVARKFGEVAAKEYRALGLATALSPQVDIATDPRWYRFGMTFGEDPQLAADMARAYIDGFQTSEGEAEIADGWGCDSVNAMVKHWPGGGSGEAGRDAHFGYGKYAVYPGGNFDEHLVPFTEGAFRLAGKTGQASAIMPYYTISVGQDSKNGENVGNSYNEYLINDLLRGRYGYDGVVCTDWGITADEGEDISRLFPGGRCWGVEEGYSVAERHYKLIMAGVDQFGGNNEIGPVIEAYNIGARKHGESFMRLRFEQSAVRLLKNMFRLGLFENPYLEADVTTATVGQAEFMEAGYEAQLRSIVMLKNEGVLPVARKKTVYIPKRSLPADTDWMGMPIPPSESYPIHLDVVKKYFAVTDRPEEADFALVCIESPRSTKGYSKADAEAGGNGYVPISLQYAPYTAEYARETSLAGDARDVLNRSYKGKSVTVSNAGDLDAVLRTKRLMNGKPVVVSILLSNPAVLAEFEREADAIVAHFGVQDQAILDILSGGFEPQALLPFQLPASMKTVEEQLEDVPHDMEAYVDSVGHAYDFAYGLNWNGVIRDARTDKYAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCY5</accession>
    <name>A0A398CCY5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF624 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_27960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00573">
        <property type="protein sequence ID" value="RIE00573"/>
        <property type="gene ID" value="D3H35_27960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006938">
        <property type="entry name" value="DUF624"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04854">
        <property type="entry name" value="DUF624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="258" mass="29401" checksum="4FA9CF3159B8728A" modified="2018-12-05" version="1">MEMRGLMGGFYKISEWIMRLAVTNVLWIICAFPFWFVMIGGFWALQSVTEDQVTSSLTQSVILLAIVSPFTFFPATSAMFSVARKWVLGDADVPLFKTFFRSYKQNFVQAMLGGIIYSVLMAVLIIDYKVYLSSMSGFGVIAYLFIALLVLLVISLHHFFSLLSHFHMKTFQLLKNAVVLTIGKPIRSLIMTIGTAAILMISYRFNFLIPFFFGSIIALFTFFNFNIVIQKMMIAKDSDSSDENEEPEIPENQRETKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD58</accession>
    <name>A0A398CD58_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00643">
        <property type="protein sequence ID" value="RIE00643"/>
        <property type="gene ID" value="D3H35_27140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="290" mass="32835" checksum="C5502804BC7235EA" modified="2018-12-05" version="1">MTKAVRNAGESNADGYERRLRLDERRRALRRERGEISLRLQAGRSEEETAALLRLLETHDEAALIDISVESRNRLSASEAERTELLERRGRLTQELERLRSEAEEKSGAQSLREQESRLERLTEQYAVLALSETLLRRTKAVFEQEKQPEVLQTASAYFGQMTGGIYRRVIAPGDSNTLLAETSDRRTIDSIFLSRGTQEQLYLAMRLALADAASRVHPLPLLLDDLFVHFDEARLRNTIPVIGDIAKKRQVILFTCHRHIAESFERELADSSIVRLNGGTVRPASAASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDM7</accession>
    <name>A0A398CDM7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_26885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00813">
        <property type="protein sequence ID" value="RIE00813"/>
        <property type="gene ID" value="D3H35_26885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046047">
        <property type="entry name" value="DUF6005"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19468">
        <property type="entry name" value="DUF6005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="313" mass="36457" checksum="AB4B9F619F1C1AEE" modified="2018-12-05" version="1">MLRVYCILDCFSYILRESRALDFRPLYIGIWDQAFELDEEGGLKYYTDGISLESFDNAGKLYGDAGRLWIGGKEAIESFLTEIGAAARSQVDHYFVALVDLFFLPYPNQSYRQRHRPHFILLNLCEDGEWQIVDPFFDWEGRIPQEVMDQALGFESNFSGIMVAADRLSFPSLESIVDQLESKMNLESNDLPSYVRNRIQLVKENKLSIRLLSSNLNQIGVFSYRKNGYTYVSSFLAEHLNFPVNELNEAIARLINEWTKVGLLAIRIGITQKQSDLERLFVKIGELDELELFIKKEIWRLYLDWKEEMRIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEI3</accession>
    <name>A0A398CEI3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_26135</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000047">
        <property type="protein sequence ID" value="RIE00855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00855">
        <property type="protein sequence ID" value="RIE00855"/>
        <property type="gene ID" value="D3H35_26135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="357" mass="40350" checksum="8DB6810112EF44B8" modified="2018-12-05" version="1">MFSGTWESGTLHKLNPDLKLGFMNMPYAPEEQNAYIFVPEDGMAANAKSKHPEEVKTFSTGCSAKRPTPKFRKRKAPSRLCGSRRTGRVLHRRSELAEYGPRHLLRQYGPVPSPTWIALGNAAQEYTFKGDADKSIDKFITPTTRQSRAKRTPSPVQSVPCEGTGCIDELKSRGGYLCKGSIFDGDILHGPITIIIFVFMVYPILQSVFYSLTDWTGIGGYHFVGFSNYKDIFSDEGFTDALKRTLFIGFSRRTRQLFRSSFCHTARSIVENQKLAPGAFLHSERHSTVVAAFVWRYILDSNTGLLNKAMVELFGSGSSILWLDSPDYVVYTIIFITVWQMWDYSYYLFGCPARRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEJ3</accession>
    <name>A0A398CEJ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DeoR/GlpR transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_26070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000046">
        <property type="protein sequence ID" value="RIE00865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00865">
        <property type="protein sequence ID" value="RIE00865"/>
        <property type="gene ID" value="D3H35_26070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="124" mass="14250" checksum="C5E51DEA8203A58C" modified="2018-12-05" version="1">MKHESAQVKELAELFDEVSEATIRRDLELLATEGKLTRTHGGAASFQHERLLSSFIWINARWRWMKKRRIAKAAADLVENGDSIILDSGSTTIEIAKQLVNHTKLTIITNDLYRFTLLFIRQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEP2</accession>
    <name>A0A398CEP2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01636">
        <property type="protein sequence ID" value="RIE01636"/>
        <property type="gene ID" value="D3H35_25185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="81" mass="8907" checksum="6F1EE488FA2799CB" modified="2018-12-05" version="1">MESYLKELNETESYSVSIGSSGGNPLASSGGKNKATVTAQFVDGTDIDQLVDRMNTELPAIVTPRKKERRSMSRRASRKAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CES7</accession>
    <name>A0A398CES7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_25685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00955">
        <property type="protein sequence ID" value="RIE00955"/>
        <property type="gene ID" value="D3H35_25685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017254869" evidence="6">
        <location>
            <begin position="33"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="7">
        <location>
            <begin position="58"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="284" mass="30254" checksum="86A05433E0345EB3" modified="2018-12-05" version="1">MKKGFIAVLAIALTLALTACGNKNNNGNGGAAAPSATVPSSPGKTATGKLADIKSAGKIILGTSAEYAPYEFHKNVGGKDQIVGFDIEIAKEIAKDFGVELEIKDMSFDNLLNELKIGRIDFVLAGMTPDSERAKVVDFSKNYYEAVQAVFVRSEDKDKFKTLADLENKAIGVQTGSTQEKIAKGIKDAKVKSLGKTTELVLELKSRKVDALIVELPVAQGYVANNPDLALTDITPKYESGGSAVAVAKGEAGLLAEIQKTLDRLTADKTIDKWVSEMTELAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEU1</accession>
    <name>A0A398CEU1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="3">TMP kinase</shortName>
            <shortName evidence="3">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="3">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">thiL</name>
        <name evidence="7" type="ORF">D3H35_25800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00975">
        <property type="protein sequence ID" value="RIE00975"/>
        <property type="gene ID" value="D3H35_25800"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01379">
        <property type="entry name" value="thiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="5">
        <location>
            <begin position="34"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="6">
        <location>
            <begin position="160"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="128"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="348" mass="36963" checksum="A8BC8D2961466B2D" modified="2018-12-05" version="1">MLPLDEFSLIRAWTERRQPKEWLSAAGVRIGIGDDAAAVEAAPDKDWLFAVDTMVEEVHFRDETMTDEDVGYKALAANVSDIAAMGGVPLHALVSVSIPPSWTPERMKRLFDGLYDCAGRYGVAVVGGDTTSAPRHLVVSVTLVGVVEQGRAIRRSGASPGQIVFVTGPVGLSAGGLHGMLGSASAAETGIPRAKKTPPPPKSLVQAHRRPAPSVKAGRLLLEQGFASSLNDVSDGLASEAWEIAEASGVSIVLKEPRLPLAGELASYARHCGVDPLEWMLYGGEDYVLLGTADKSSEAELRALFRSEGLPLFVIGETEAGDAGVWLDSEGGKRKPLDKRGYNHFARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF42</accession>
    <name>A0A398CF42_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">glpK</name>
        <name evidence="9" type="ORF">D3H35_23510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer and homodimer (in equilibrium).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01343">
        <property type="protein sequence ID" value="RIE01343"/>
        <property type="gene ID" value="D3H35_23510"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="7">
        <location>
            <begin position="4"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="8">
        <location>
            <begin position="259"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="243"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="409"/>
            <end position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="498" mass="54448" checksum="3C96726F11BDDF6D" modified="2018-12-05" version="1">MEHYILALDQGTTSTRAMLVNKRGEIAGMVQQETRLSYPHPGWVEADAERIFGSSVEVVRQLFDDTGVTAAAIAGIGIANQRETTVVWDRESGLPVYPAIVWQSRQTEELCGQLRARGLERIFRDKTGLLIDPYFSGTKIAWILEQVEGAREKAERGELLFGTIDSWLIWKLTSGRVHVTDATNASRTLLYNIHDRRWDDELLAILGIPSAILPEVRSSSEIYGYSDAEWFGQAVPIAGVAGDQQAALFGQGCFEEGSAKNTYGTGCFMLMNTGRKAVASSSGLLTTIALELGGKTEYALEGSVFVAGAAIQWLRDGMGLIEASEDSEKLAQSVESTEGVYVVPAFVGLGTPYWDSDARGSVFGITGGTTKAHFVRATLESLAYQTKDVLDAMEKDSGLKLRTLAVDGGAAKNDFLMQFQSDIAGVPVERPEQVESTALGAAYLAGLAVGYWQDREQIGSLRRVERLFRPMLEEGRSRELYEGWRRAVSAARSFKRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFW7</accession>
    <name>A0A398CFW7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_15100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02086">
        <property type="protein sequence ID" value="RIE02086"/>
        <property type="gene ID" value="D3H35_15100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0946">Virion</keyword>
    <feature type="domain" description="NTP_transferase" evidence="5">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="247" mass="26963" checksum="31D19E229331DB27" modified="2018-12-05" version="1">MKGIILAGGTGSRLFPLTKVTNKHLLPVGKYPMIFHAVFKLKQAGIQDILIVTGKEHMGDVVNLLGSGKEMGVSFTYKVQDEAGGIAEALGLAEQFVGAEPMVVVLGDNVFSDDISGYLTNFKKQRSGAKILIQEVADPQRYGVPELHGDRIVSIEEKPAIPKSNFAVTGIYMYDNSVFEIIKNLRPSGRGELEITDVNNAYIASNQLSYDILVGWWTDAGTHASWAKANELAQDIVYGEEFGKIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG54</accession>
    <name>A0A398CG54_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NarK/NasA family nitrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_15765</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02196">
        <property type="protein sequence ID" value="RIE02196"/>
        <property type="gene ID" value="D3H35_15765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17341">
        <property type="entry name" value="MFS_NRT2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="PTHR23515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="10">
        <location>
            <begin position="13"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE02196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="410" mass="43818" checksum="183748536878F5BA" modified="2018-12-05" version="1">MAGKGFLQAGHKPSLFSAFAYFDVSFMIWVLLGPLSIIIMKDFDLSAAQKANLVALPILGGSILRLVLGFLTDRIGPKRTAQLGMLITFIPLIWGWQFAHTLSSLHYVGLLLGVAGASFSVALPLASRWYPPQYQGLAMGIAGAGNSGTVFTTLFANRIATYYGDWHVVFGFALIPIAVVFVVFSLLAKDSPNQPAPAKLIDYGRVIAKRDTWIFNLLYSVTFGGFVGMSSYLPIFFNTQYDLSPIQAGNFTTLCVIAGSFFRPVGGWLADKLGGIRMLLLLYAGVAVLLAFISTLPSLTLITVLLFAMMMLLGMGNGSVFQLVPQRFSKQIGLVTGIVGAAGGLGGYFLPKILGNVKQATDSYSTGFLILAGIAVLCIIAILAVQKSWKSSFVGEGGRANAIVPKELSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG58</accession>
    <name>A0A398CG58_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_12945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01713">
        <property type="protein sequence ID" value="RIE01713"/>
        <property type="gene ID" value="D3H35_12945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016701">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LigB" evidence="5">
        <location>
            <begin position="19"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="255" mass="28816" checksum="BFA4851291E1170F" modified="2018-12-05" version="1">MLSPVFLPHGSPYTIFEKSEFTAFLNRFGKENRPKAIVIFSAHFESETTTISATDDVHEMVYDYYGFPPEFYKVQYPARGSTIVASIVEERFRRRGIPVQQKYRGLDHGVFPVLLHAYPEADIPVVPISVNPFLPAKQQIAIGEALQGLEQEGILVIGSGMLTHNFNEFDRDRHAPPREWAVQFIDWIREKALARDIDALSRYESLAPYSAKAVPRPEHFVPLLIALGSGTPGREVLELYDSLEYGSLSSLSLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH46</accession>
    <name>A0A398CH46_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00409">
        <property type="protein sequence ID" value="RIE00409"/>
        <property type="gene ID" value="D3H35_28775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="300" mass="33683" checksum="30799ACAA78301FF" modified="2018-12-05" version="1">MLSVGIFNGYYPYSLEESIARIKKDGFSCVQLDLTFKGMDLSPEAITIEKCRQIRDAFRDANLPIVAVSGYTNIIHPDKKKREQNLHGLKTVLKFARELGSPYVVSETGTYNMDSDWVWDERNGTEEAYEETAGIIEDLAKFAYDHGSVFLVENYVNNVIGSVERLTRLFGDINHPGLGLLMDPTNYFTDSNIGSVDKEINRIFDTLGPRIKLAHAKDCKPAEDTSEKHADIDATEAHSFRGAGAVELPAPGLGILNYDLYLQRLYKLHPNVPIIIEHLDETDIPRAKRFLDGKLKEIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHF3</accession>
    <name>A0A398CHF3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_18315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02636">
        <property type="protein sequence ID" value="RIE02636"/>
        <property type="gene ID" value="D3H35_18315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031621">
        <property type="entry name" value="HisKA_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16927">
        <property type="entry name" value="HisKA_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="311"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="423"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="562" mass="64854" checksum="C6A7E06A2C834335" modified="2018-12-05" version="1">MFQTIREKVNALGVSWPDFLLFIALFILFICVLAFNRITQTHKVYLAFHFIMMLWPLGQFLTATAGLAEYQLYFVKLSFSALALLGPGWLVFVFFLTGRASHLKSGRFYLYMLPSLLSVAGVIWNPNELFMKSIGDDYFNREYGPLFWLLVITEFVYFFTALLNMFSALKTVNSLNQRKQLATAVIGMFVLTGFSVLDMLINVFLSPWLPVIPGLMSIGILLSDCCFVVAIYRFGMFDILSMAQRDIFEHMTMGIIVVDENGKVLEVNRGALPFVTTSKGNTFEMEKFLSPLRAQGEVYEFLYKYRHHPQERMQLEIALQDNQNRHVSILISPVLDDRRTLLGRVITFHDVSELRKLVDEMNRKNEALHERNLELITIQEELFRVNQKLEQMAVTDGLTGCYNRRYLMQQMEHEVLLNMRYHIPFSVFLFDIDHFKQINDRYGHLVGDEVIRGTADAVRAKLRRTDILARYGGEEFTIYLPHTNREQAELLADRIMTAISDNIVHSGNEQVNVTISMGILSEDSADLHFDDPKEYLRELFSRADSALYKAKNEGRNRVVAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI18</accession>
    <name>A0A398CI18_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphate ABC transporter ATP-binding protein</fullName>
            <ecNumber evidence="5">3.6.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pstB</name>
        <name evidence="5" type="ORF">D3H35_20040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.27" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02906">
        <property type="protein sequence ID" value="RIE02906"/>
        <property type="gene ID" value="D3H35_20040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="258" mass="28911" checksum="F31976035470B48C" modified="2018-12-05" version="1">MRPEETVMQALIEIERLNLFYGSFQALKNVNMKIPEKAITAFIGPSGCGKSTLLRSLNRMNDMIQGTNIEGSIKISGTDIYGKDVDVETLRKKVGMVFQQPNPFPKSIYDNVAYGPRLHGIKSRQKLDEIVETSLRGAALWNEAKDHLKRSALSLSGGQQQRLCIARALAVEPDILLMDEATSALDPISTLKIEELAQELKDKYTIVMVTHNMHQAARVSNQTVFFLNGEVIEYADTEKLFSNPEDKRTEDYISGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI58</accession>
    <name>A0A398CI58_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01702">
        <property type="protein sequence ID" value="RIE01702"/>
        <property type="gene ID" value="D3H35_12880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="134" mass="14960" checksum="6DB51F689D841773" modified="2018-12-05" version="1">MIIIFLGSVLISLILGFITNGRLFNDQLRVFVHDNLVSKGKTIIQAYEQSNPDNQDTLMKGLTALENYSIRMFDMEGNPLHETDPPPNPSLEVSSEQLRDVLNGGVYWSNSARGPSKWYSDFPLKLTGSPLLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIA5</accession>
    <name>A0A398CIA5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02473">
        <property type="protein sequence ID" value="RIE02473"/>
        <property type="gene ID" value="D3H35_17390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="246" mass="27620" checksum="3F7B805CF2B144CE" modified="2018-12-05" version="1">MRGHTFSTFSRMMLLACIIFDLAAIVSFFAIFQWFIVLDPLKSIMMLLVLLSGLMLVNVALVFPGALLRKAGVAYSTAIIFLTLLYAVVSNTLSVIFVFGSGIWYVVWELLALAVFLCLFAVIGFFSKSASEDMTGEALEQTAKGLLQVRLMEIEEILITKRHEEGMQPVIDSFARLKERIQASTPFMRITNNRAVNDAENKISEKLEYLLASLEASKINPHSFDAQGLIEETRRLVVQREQLIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIA8</accession>
    <name>A0A398CIA8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lasso peptide biosynthesis PqqD family chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_13295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01772">
        <property type="protein sequence ID" value="RIE01772"/>
        <property type="gene ID" value="D3H35_13295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="96" mass="10551" checksum="B9B5E1807A0B10A3" modified="2018-12-05" version="1">MTMQLAGSTNIRQKDGYVTSEMDGELVMLSVENGKYYNLGIVGGQIWQLAQGQGMTVAEIVARLVSEYEVTESQCEQEVAAFVEQMEKAGIIAVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIB7</accession>
    <name>A0A398CIB7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01782">
        <property type="protein sequence ID" value="RIE01782"/>
        <property type="gene ID" value="D3H35_13350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="309" mass="33769" checksum="70D49F624FDDAEA6" modified="2018-12-05" version="1">MKIVQLSAIVGIWSAVFLNGCTDETSTSAPLPSSSSISSASPSSVSADSGSRIEQVDFHSAALDSEMSLSVYLPPAYSPAVEYPVLYLLYGYGGTHDSWFTYLRINEASDRLIQENRIDPVIIVSPDYGNSFGVNTKAGESKDPGGVSIGPYEDYLIQDVVSYVDSHYSTRTSRDGRYIGGASMGGYASLFLGLTHPDLFSKIGAHSAAIWNYTSTDQFTDQRDWLYANEALRDERDPFKLAESGKLSGTRIYLDAGEADALAEKDRSLYERLNDLNVDAQWVSNPGGHDAAYWSGQLESYLLFYAGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIC5</accession>
    <name>A0A398CIC5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01792">
        <property type="protein sequence ID" value="RIE01792"/>
        <property type="gene ID" value="D3H35_13410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="24"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="149" mass="17196" checksum="97BC7B8F8DA53697" modified="2018-12-05" version="1">MAEKELIGLDAQPREAEKKPHLKRVLSNYLPVSNLERATKWYEEVFGLTVRKREPDGAILILGDGQWLFLLEAAEKRTANFFTRQWDGERYEMFSLTFEVENIAGLHKRLRESGAEVEPLADHGDCGLQFKFKDPDGNKFNVWQDPATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIP7</accession>
    <name>A0A398CIP7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_21840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01069">
        <property type="protein sequence ID" value="RIE01069"/>
        <property type="gene ID" value="D3H35_21840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="183"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="204"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="699" mass="79957" checksum="CC5D8A98CCF39677" modified="2018-12-05" version="1">MDASTELYTEERSRLDETFGEIERQRAGIGPVYYGNDFVEQLLEEKREETRRRLALLGSEPYFGRLDFQEKGKQSEPSSLYIGKRGMDRTETGEPYIIDWRAPVASLFYSFTGGDAPVAYEAPEGTIHGEVHRKRNLSIRDKELQRVVESYVRGGDNLGLSDDFLLYRLGEKKDNRLRDIVSTIQAEQDSIIRAPRHKALIIQGAAGSGKTTVALHRLAFLLYQYQGQIRAERMIIFAPNAMFLDYISGVLPELGVGEVKQTTFAEWALDRIGTKLTLPDHTDDKWFSLAKKRPNIDDETPGRFKGSDSFRLWLDGKLRQYEESYLQDHDFEAWDRRVLKASLIRQWFEVEYRHYPLAARRERLIGRIKRWLDMQLNEIGDPKIRKEKTKTSKQKLRTHLKKLPEIDEVAFYRSLFDQPNEFVPSDIAKETKNGLKRGSAQPEDLAPIVWIRKYFHGPEGLTFDHVVVDEAQDVSPFQITLLGSFMVEPSYTILGDLAQGIHAYRGVHRWEELASVFDENYSSYHELKQSYRSTLEIIEFANRILPFTDTGLPPAEPVFRSGDPVKLVQVANDAERLAYIRDFIRDQQAGSMRTISLIGRTAEDCTKLHERLTAEGIDTNLIAEGQSHYRGGVSIVPVHLAKGLEFDAVLLLDADRDRYPASPQDAKLLYVGCTRALHRLTLLHEGEPSELVTAADSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIX9</accession>
    <name>A0A398CIX9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_12790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000038">
        <property type="protein sequence ID" value="RIE03246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03246">
        <property type="protein sequence ID" value="RIE03246"/>
        <property type="gene ID" value="D3H35_12790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="2">
        <location>
            <begin position="18"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="3">
        <location>
            <begin position="119"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="278" mass="30494" checksum="3B160C671E9D2C53" modified="2018-12-05" version="1">MGQYRQFAGSEQADGSWENGKYILNGVKKFTTGTPDSDRVMLYFRDANTSETLQGVIPRDRAGVTVHDDWNGFGQRQTGSGTVTFDNVALEEDEILKENESYGKDGYSPPLTQSVLTNIYLGIGLGALEAARKYIHEHSLPYALSGVEAASRDPYILRKYGELWAELKGAESLADQASAQLDRVTALGARTSEEERAETAALITAANVQTGKASLDAANRFFELTGTRSATTDNGFDRYWRNVRIHTLHNPLDYKLRNIGDWALNGTPPPLPVAGVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ86</accession>
    <name>A0A398CJ86_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyr_redox_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_16995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02405">
        <property type="protein sequence ID" value="RIE02405"/>
        <property type="gene ID" value="D3H35_16995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="446" mass="50111" checksum="AD1FBD0FDA7E5427" modified="2018-12-05" version="1">MIRVVILGGGYVSVWACRSILRKINRQVRKGEVQITVISTENYHAYHGWSGEVLGGIIPLQHQRSSLRNLLPHVRFIRGEVAEVDLEASELTVRINGEASRSVIVSYDHLLFGLGSRSYDERISGSADNGFRLKDPRELLKLRNHLIDVMEQAEAEEDERIIDQWLTVVVAGGGFEGVEICAAISELFQKSKKHYSVLRSHQPRIVLVHAGTALLPQFRPHFNKLADYATAQLRQYGVEIRFQEAVEAIEPEGARFSTGEIIASRTVIAAVGQKLAPLRGSESLPRDKDGRLLTDSSLHIVGSSKLWAGGDIANVKHYRTGKTCPPNALWAIYHGKRTGDNIARSILGKPLRPFRYPGLGQAASMGVGKGIGELYGIQLRGWFPWLLRLFFFLRFMPSRRQMLRIFMDWMLHPFGGHDLSSIDYEQVVRKEASNSIANRREELVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJG1</accession>
    <name>A0A398CJG1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_16225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02272">
        <property type="protein sequence ID" value="RIE02272"/>
        <property type="gene ID" value="D3H35_16225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017428810" evidence="2">
        <location>
            <begin position="30"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="414" mass="43380" checksum="46EE47021DD73CB0" modified="2018-12-05" version="1">MMKTTLQITGACLLAIALLAGCSSNSESALPSSSSTAITALPTQPAASEPSNPAEGTEAASPEPTATPSTSPIGSIPLSTVTALRLATPLSGWAGGENWIARTDDGGKHWKKQYTHKGMTKQLFALNSRTAWATIGSTDAQKLTLLKTKDGGSRWTTAGTVPNDGFLHFVSETEAFSANAITIDGGKSWKTLGAPDHAIGDVYYHDRNNGWAVSAVEGADYFEFQRTTDGGKSWKTVFTRKTSVIPSDSVIRSAGKNDAWIELIGDSGMTQTSYSLFHTSDGGGKWQPVLANSGAGSGPAPGFAMDEKTVPRNGGNSPGELYVVNTTTAFMGGQCQACDDGNTMGKTTDGGKTWTNLKAEYPGYGAQHIAAADAKHVWWINTDPAAPSVMYTTADGGVSWKTTYTFATPKPSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJY3</accession>
    <name>A0A398CJY3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_20675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03013">
        <property type="protein sequence ID" value="RIE03013"/>
        <property type="gene ID" value="D3H35_20675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="115"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="188"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="251" mass="28569" checksum="FD0040F0C0DC7892" modified="2018-12-05" version="1">MTVLSQQIRYLSGEEVERADRFEVAFNRIHAQLRKLAPNERDDSFTSLLYKVSDRYSHVRANRENLRQYAKLRNALVHEYFGQDHYIAVPHKQVVAQIEAISEQLARPKNVLTIAARPVVAFQAGTPLSEVLATIERHSFTSYPVYQGTSFVGLITEDGISKWIAAQLRLSPIVDFGPVLIDHTLPFESPHNVVFVSSRTNVLEVEDLFEERLREREKIEAVIITDTGHSEEQALGIITSWDLVKVDAWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJZ1</accession>
    <name>A0A398CJZ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02620">
        <property type="protein sequence ID" value="RIE02620"/>
        <property type="gene ID" value="D3H35_18230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="128" mass="14071" checksum="36A3D42C4AA197C7" modified="2018-12-05" version="1">MSLDGWNRYCCAKAERASGDDGGGASEGGMPKVGLVPLFRRSTKEVSTMAYRKSKVYSDVSPTARRYSPERGDRLLSSPMPPKSVEEADNGSMVQDLADLKRLGKDMERVKTGQELQEEGFVSDPIQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKI0</accession>
    <name>A0A398CKI0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="10">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="10">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">gatB</name>
        <name evidence="12" type="ORF">D3H35_18460</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="10"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02662">
        <property type="protein sequence ID" value="RIE02662"/>
        <property type="gene ID" value="D3H35_18460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="11">
        <location>
            <begin position="331"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE02662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="480" mass="53219" checksum="FD85394703B059AB" modified="2018-12-05" version="1">MSTMNKYETVVGLEVHVELHTQSKIFCGCSTSFGAPPNTHTCPVCLGHPGVLPVLNRQAVEYAMKAAMAINCEIAEWCKFDRKNYFYPDSPKAYQISQYDQPIGQNGWIDIEVNGVTKRIGVTRLHLEEDAGKLTHIEGGYGSLADFNRVGTPLVEIVSEPDIRSPEEAKAYLEKLKAIMQYCDVSDVKMEEGSLRCDANISIRPRGQKEFGTRTELKNMNSFRGVQRGLEHEELRQADVLDSGGRVVQETRRWDEGQGKTISMRSKEEAHDYRYFPDPDLVRLHIDAEWKARVKASIPELPDARQARYVAEYGLSSYDAGVLTASMKLADFFEDSLKYTSDAKASANWIMGELLGYLNSNGLELQDVKITGQGLGEMIQLIEKGTISNKIAKTVFKGMIETGRSPQQIVEAEGLVQISDEGAIIAVVDAIIAANPQSVEDFRGGKDKAIGFLVGQIMKETKGKANPGLVNKLLMDRLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKN2</accession>
    <name>A0A398CKN2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA modification GTPase MnmE</fullName>
            <ecNumber evidence="6">3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">mnmE</name>
        <name evidence="6" type="synonym">trmE</name>
        <name evidence="9" type="ORF">D3H35_24030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01438">
        <property type="protein sequence ID" value="RIE01438"/>
        <property type="gene ID" value="D3H35_24030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TrmE-type G" evidence="8">
        <location>
            <begin position="220"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="230"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="249"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="274"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="458" mass="49514" checksum="6827DA2BCCDFEC54" modified="2018-12-05" version="1">MVEDTIAAIATALGEGSIAVVRVSGPQAVECIAPLFRSKSDLREVASHTVHYGRIVDPANDTVLDEVLVTVMRGPRSFTAEDVVEISTHGGIVAVKSVLELVLRHGVRMAEPGEFTKRAFLNGRIDLAQAEAVIDLIRSKSERAFQVARKQVEGDLSKQIVPLRAQLIELLAHVEVNIDYPEHDVAEVTAGVIRDTCGEALKKVRQLLDRANEGKILREGIVTAIIGRPNAGKSSLLNALARDNKAIVTDIPGTTRDIVEESVSVGGIPLRLLDTAGIRETTDVVEQIGVERSLGALNDADLILLVLNHHEPLHEDERKLLEQVKDRSTLVVVNKIDLSGSLDLDEVIALVGQDRIVRLSAKEGTGLEELEQAVARLFFSGTVETGDLTYVSNARHIALLHRTQISLTDAIDAADEGIPIDLIQIDIAASWESLGEILGDSAGESLLDQIFSQFCLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKP7</accession>
    <name>A0A398CKP7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA ligase</fullName>
            <ecNumber evidence="11">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">ligA</name>
        <name evidence="13" type="ORF">D3H35_29915</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="11"/>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00251">
        <property type="protein sequence ID" value="RIE00251"/>
        <property type="gene ID" value="D3H35_29915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="591"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="11">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="32"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="80"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE00251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="671" mass="73391" checksum="F0E5F5986783C3DA" modified="2018-12-05" version="1">MTEPAARMRELVFELNAHSHRYYTEDSPTISDKEYDVLYDELSSLEAETGTVLPDSPTRRVGGDILKGFAPHRHLSRLWSLDKAQNVDDLNAWAARASRLIADYNARNPEQPLPDPEYALELKFDGLTLNLTYSDGELVQASTRGNGEVGEGILAQLRTIRSVPLTIGYTEGTIEVQGEGIMRLSVLEEYNKTAAEPLKNARNAAAGALRNLDPRVTSSRKLDAFFYNVGYTDGLAFDNHRQMTAFLRENRFPVNPYVHYFGSIEELSEELTRIAESRNTLDYLIDGAVVKLVDMRTREALGYTDKFPRWSVAFKFEAEETTTVLESVSWEVGRTGKVTPLARVEAVELAGVTVQNCTLNNIGDIERKNLKHALGTRIFIRRSNDVIPEILGKADDEEGGEIAVPTACPGCGSPLEMKGAHLFCVNKLGCKPQIVGRITHFASRDCMDIETFSGKTAEQLYEELGVRDPADLYSLTFEDLVKLQRFGEKKATNLIAALEKSKSRELSAFLNALGIPNTGKATAKMLAEHYGSLDPLIAAEAEELTGLPDVGGIVAESIVTFFRDPIMLSSVERMRAAGVKAESAKAAAPADESHPLFGKTVVLTGTLTLMGRDEAAKRLEALGAKVSGSVSKKTDLVIAGESAGSKLAKARDLGVAVLEDEAELLKLLGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKW1</accession>
    <name>A0A398CKW1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_20735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03025">
        <property type="protein sequence ID" value="RIE03025"/>
        <property type="gene ID" value="D3H35_20735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="182" mass="20166" checksum="4851F34CC484F235" modified="2018-12-05" version="1">MKERVTVQRSWGIGEIAMKKRVTYSAAGGIDEIAMKERVTVQRSWGIGEIAMKKRVTYSAAGGIDEIAMQERVTYSAAGGIDEIAMKERVTVQRSWGIDEIAMKKRVTYSAAGGIDEIAMQERVTYSADGGIGQIAMKEWVTVQRGWVSRRNSHEGAGYVQRGWGNRRNSHEEAGYDAARMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLL5</accession>
    <name>A0A398CLL5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03122">
        <property type="protein sequence ID" value="RIE03122"/>
        <property type="gene ID" value="D3H35_13395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022290">
        <property type="entry name" value="CHP03858_lucif-like_mOase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03858">
        <property type="entry name" value="LLM_2I7G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="349" mass="37998" checksum="B3E4100FD69AA654" modified="2018-12-05" version="1">MEIGISTFLETTPDPVTRKVISHAERLRHAVEEIVLADQAGLDVYGIGEHHRADYAGTAPAVVLAAAAAMTKRIRLTSAVTVLSSDDPVRVYQAFSTLDGISNGRAEIMAGRGSFIESFPLFGYSLDDYDELFEENLELLLAIRASEKVTWRGGHRPAIPNLGVYPRSVQTPLPVWIASGGNPESAVRAGALGLPIAFAIIGGMPERFAPLVNLYKEAAAKAGHNPDALQIATHSHGFVGETTEQAADLFFPSTQAQMNVIGRERGWPPYSRDSYDAARSLRGALYVGDPEFVAEKIVLLRRNLGITRFFLHVNVGTMPHREVLRAIELLGTKVAPIVHKELARIEKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLQ9</accession>
    <name>A0A398CLQ9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D3H35_17500</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03172">
        <property type="protein sequence ID" value="RIE03172"/>
        <property type="gene ID" value="D3H35_17500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="309"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="11">
        <location>
            <begin position="373"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="12">
        <location>
            <begin position="445"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="510"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE03172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="717" mass="80801" checksum="CF833F026246E03B" modified="2018-12-05" version="1">MLTIAKQIGTSLQASEKSRRFMEDTIGERLRAAAIAIQNELDPRIDQVRNEQLVLLSRKLGVDQITLWKRTADNIIPVKSSDPSEINDTGAKSWDYWYTAFTQLFELQPVTVSQGQKLTNFWAGPIQYASSNPDQINKWGYYYDGTTDYIINPYINAQTFIDFENNIGTNALVRNLLADNPDILGITGFDPEFFGMPPIIKMKKGKLVRNLDVRDIAFGEYTFRDLENDINNVRYTAKTGEMLTTTEYLNGKHVMKSFISLGAQTKFVVGVSFDLKAIEKSLNHQLFLHSTISLGLVLAAWLASYIIAGFLIRPLRQILRNVNEIAQGKFDKRMAIRSHDELGLLSSRVNTMARNLQTYTGQLKESAAELKSTKEYLESFVNQTWDAIHVTDLHGQVIQINHAFEKMYGWSAEEALNKPQQDIPDDLLREYEDIRGRVLRGESVADHETVRRKKDGQSIDVSITVSPIRNEAGEIVSIAEISRNITARKETEEVIRRSEKLSVVGQLAAGVAHEIRNPLTTLRGFVQLHQKKGSLSDIHLDVMLSELDRINFIVSEFLVLAKPQVSHFQPGYLQHILHDIIMLLDSQASLSNVRFETKFALKVPSLICDTNQLKQVFVNIMKNSIEAMPNGGTITIELNHIPDEQAAAIRIIDNGCGIPEDELPRLGEPFFTKKPSGNGLGLMVCQRIIANHKGHILVSSRLGKGTCVEIWLPMRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLZ7</accession>
    <name>A0A398CLZ7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Flagellar basal body rod protein FlgB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">flgB</name>
        <name evidence="7" type="ORF">D3H35_11350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03280">
        <property type="protein sequence ID" value="RIE03280"/>
        <property type="gene ID" value="D3H35_11350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006300">
        <property type="entry name" value="FlgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30435:SF12">
        <property type="entry name" value="PTHR30435:SF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002889">
        <property type="entry name" value="Rod_FlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01396">
        <property type="entry name" value="FlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="6">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="138" mass="15132" checksum="F0086A243014F37E" modified="2018-12-05" version="1">MNVLGGASFGRLEGALHAASLRQQVLSNNVANVDTPFFKRSDVAFEELLTQAMDGEGTSVLPGRLTNERHIPIGGSSYSSPAPQIVTEDSTVINNDKNNVDIEKEMSMLAENQLRYNLFVQQINHDVKMMRIGIDGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM30</accession>
    <name>A0A398CM30_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_26235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00701">
        <property type="protein sequence ID" value="RIE00701"/>
        <property type="gene ID" value="D3H35_26235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017367111" evidence="7">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="79" mass="8297" checksum="94ABAA72460EBC73" modified="2018-12-05" version="1">MIRKPFAAPVVMLLLCAASVVASAALGKMALSPLEAIRGLLGIGAEDHEMVIRNLRLPRILVALLAGASLAASERCFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM66</accession>
    <name>A0A398CM66_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="6">2.7.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphatidylglycerophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">pgsA</name>
        <name evidence="19" type="ORF">D3H35_11750</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein catalyzes the committed step to the synthesis of the acidic phospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03352">
        <property type="protein sequence ID" value="RIE03352"/>
        <property type="gene ID" value="D3H35_11750"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006655">
        <property type="term" value="P:phosphatidylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RIE03352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="197" mass="21873" checksum="8528271B36CF82AF" modified="2018-12-05" version="1">MNLANKITLVRIFLVPIMTIFLLVKLDLGILTIGNYSITYNQLCALLLFIIAASTDGLDGYIARKRKIVTNLGKLLDPLADKLLLAAVLIALVEMDKLDAWVTIIIISREFAITGLRQVALLEGAVLAASKWGKWKTAIQIAMVIVLLLNNFPFNFLNWRVDLIAVWASVLITAYSGIDYFVKNKNLIPISDAQQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM67</accession>
    <name>A0A398CM67_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Aspartokinase</fullName>
            <ecNumber evidence="15">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">D3H35_26465</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 15">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="15"/>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00741">
        <property type="protein sequence ID" value="RIE00741"/>
        <property type="gene ID" value="D3H35_26465"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04261">
        <property type="entry name" value="AAK_AKii-LysC-BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041740">
        <property type="entry name" value="AKii-LysC-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00656">
        <property type="entry name" value="asp_kin_monofn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 15 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="17">
        <location>
            <begin position="264"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="173"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RIE00741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="417" mass="44335" checksum="F84E79D3FE47F84E" modified="2018-12-05" version="1">MSLIVMKFGGSSVGTTERMGRVAQRIVDQKLQGHRVVVVVSAMGDTTDDLIDKSKEINDNPPAREMDMLLTTGEQISVALLSMAIHKLGHNAKSYTGWQAGIVTEAVHAKARISDISPDRIFKALDDSQIVIVAGFQGMTEDGEITTLGRGGSDTTAVALAAAIKADVCEIYTDVDGIYSTDPRVVKCARKLDVISYDEMLELAHLGAAVLHPRAVEYAKNYNVNLVVRSSFSQNPGTLVKEEAEMEQGIVVRGIAFDKNVARISVLGVVDVPGVLASMFGALAAEGIDVDIIVQSGVSNGTADFSFTVALSDRANAIRVIESIKSKVPFSELTYEENLVKVSIVGAGMVSNPGVAATMFDAISKQGVSIKMVSTSEIKCSCVIAAEPLQDVVRALHTAYGLDTEVAAFVGGPQDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM70</accession>
    <name>A0A398CM70_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03545">
        <property type="protein sequence ID" value="RIE03545"/>
        <property type="gene ID" value="D3H35_10885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="191"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="291" mass="33623" checksum="6829D9DE6CADE6BD" modified="2018-12-05" version="1">MELLEFTVPPLLHYIASGYTEFAVGDRHMARRNIRVFDLLVVRRGCLYIGEEDRKYEVSAGSALLLRPDCHHYGTEDCKEKTEYYWLHFHTTGSWTAASEDSARHEPEPYEEGTDSHVFDIRPFTVALPQYVKLLQIGKLEELLEQIAALGPEGHRSASRFKQQILFQEAVRQLSASVVTERSTPSTVCAEQAAAYLRSRYREEITAREMGESLNFHPVYIARCMNKEYGCSPMEYLLRYRIEQSKLLLMQTDYTVARIAEEVGFSQAAYFSSCFHKTEGISPRQYRQRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMD3</accession>
    <name>A0A398CMD3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03422">
        <property type="protein sequence ID" value="RIE03422"/>
        <property type="gene ID" value="D3H35_12205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="42"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="265" mass="29002" checksum="399E1A8F5236AE37" modified="2018-12-05" version="1">MNIELGLLTGNDKGAINEGCPSLTPYLLEGKGPYPVVIVYPGGGYGNRADHEGEPVARWLNELGVSAFVLNYRVAPFKYPDPHDDATRAIRTVRARADEWKLDPDRVGILGFSAGGHLASSSGTHYDRGNPAAEDPIERVSSRPDLIILCYPVITMGDYTHEGSRTNLFGDNPSPELIDAYSNENQVTSDTPPTFLWHTADDGAVHAENSLRFASALIRHGVSCELHLFESGRHGLGLAADHEGVRVWSELCEAWLKARHFIRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMT4</accession>
    <name>A0A398CMT4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000035">
        <property type="protein sequence ID" value="RIE03602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03602">
        <property type="protein sequence ID" value="RIE03602"/>
        <property type="gene ID" value="D3H35_10710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="70" mass="7556" checksum="C47CD30A4968FB33" modified="2018-12-05" version="1">MSKLRSIAKDKPNLAVVPFDEGTVQCIALNLQGRGALAQPAGRVVQRGRKILGSSIPSRKETTPRIQPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMW2</accession>
    <name>A0A398CMW2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_25465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00921">
        <property type="protein sequence ID" value="RIE00921"/>
        <property type="gene ID" value="D3H35_25465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="252"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="501" mass="55094" checksum="B20AA369FB660639" modified="2018-12-05" version="1">MNENYAVEMIDISKAFSGVTVLNGVDLRLKKGSVHALVGENGAGKSTLMKILTGMYSDYGGTIVLEGTEVRFGSEREALQAGIAIVAQELTPIAELTIAENIFLGREPQTRVKGVISYRRLFDQTKELMTKLGLSYDPRTKMKELSVAETQMVEIIKAISRNSKIIVMDEPTSALTNAETEYLFRQIDALKAQGIAIVFISHKFDEIFRVCDTVTVLRDGKFIGTHPIGELTQDKIVAMMVGREITDIYPPLEEPGASIAFEVSNLTRKGEFEDVSFRVRQGEIVGISGIMGAGRTEVARTIFGLDRPDSGNFNLMGQTVTIRSPEQAIRLGIAMASEDRKNLGFVGVRSIKDNIALPNMDIFSRWAFILRNKLNGRASEISGSLAVKATSLDMPVSQLSGGNQQKVVLAKWLVRDIKLLILDEPTRGIDVGAKAEIYKLMRDLARQGIPIIMISSELPEVIGMSHRVLVMAEGRIQGELSRGEAMQENIMKLIVNAKKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMW5</accession>
    <name>A0A398CMW5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe-S cluster assembly protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sufB</name>
        <name evidence="3" type="ORF">D3H35_08310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03953">
        <property type="protein sequence ID" value="RIE03953"/>
        <property type="gene ID" value="D3H35_08310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="46"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="464" mass="52102" checksum="836C6D1EE6062F7D" modified="2018-12-05" version="1">MAKQMEFEEYKYGFRDEHKAIFQSGKGLTPEVVKTISEIKGEPEWMLKFRLKSLEQFNKMAMPTWGGNMDDLDFEDIQYYVRPSEKQGKTWEEVPEEIKATFDKLGIPEAEQKFLAGVSAQYESEVVYHNMQEDLEKQGVIFTDMDTALREHPEIVKEYFSTIVPPTDNKFAALNSAVWSGGSFIYVPKGVKCEIPLQAYFRINSENMGQFERTLIIADEGSFVHYVEGCTAPIYSTNSLHSAVVEIIVKKDARVRYTTIQNWAPNIYNLVTKRAVAEENATMEWVDGNIGSKLTMKYPAVILKGRGAKGMVLSIAVAGKGQHQDAGAKMIHLAPDTTSTIVSKSISKHGGKVTYRGLASFGRNAEGAKANIKCDTLILDNQSTSDTIPYNEILNDNITLEHEATVSKVSEDQLFYLMSRGMSEAEATQMIVMGFIEPFTKELPMEYAVEMNRLIKLEMEGSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMY7</accession>
    <name>A0A398CMY7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polymer-forming cytoskeletal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03835">
        <property type="protein sequence ID" value="RIE03835"/>
        <property type="gene ID" value="D3H35_09790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007607">
        <property type="entry name" value="BacA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35024">
        <property type="entry name" value="PTHR35024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04519">
        <property type="entry name" value="Bactofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="139" mass="14275" checksum="EB0DD5825A6F3E54" modified="2018-12-05" version="1">MFKEKFKLSAGETDTLIGHGTEMEGRLRSEAGVRIDGTFTGDIDCKGDLVIGEKGEAKSSITARDVTIAGKVHGDVHTRGKLVITSSGQLHGDSYAATLIVQEGGVLNGSSKMERAEFGKAAAVGHDGGSGGGKTKQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMZ0</accession>
    <name>A0A398CMZ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CsoR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02158">
        <property type="protein sequence ID" value="RIE02158"/>
        <property type="gene ID" value="D3H35_15530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="83" mass="9201" checksum="37CD45993F9887CD" modified="2018-12-05" version="1">MKANLMTRLNRIEGQVRGVKGMIEKDTYCDDVLNQIAAIQSALGSVGKLLLEGHMRSCVIERIQEGESAVIDELLVTINKLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN06</accession>
    <name>A0A398CN06_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Alkanesulfonate monooxygenase</fullName>
            <ecNumber evidence="2 6">1.14.14.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">FMNH2-dependent aliphatic sulfonate monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ssuD</name>
        <name evidence="8" type="ORF">D3H35_04435</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the desulfonation of aliphatic sulfonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an alkanesulfonate + FMNH2 + O2 = an aldehyde + FMN + 2 H(+) + H2O + sulfite</text>
            <dbReference type="Rhea" id="RHEA:23064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:134249"/>
            <dbReference type="EC" id="1.14.14.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SsuD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.5" evidence="2 6"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04736">
        <property type="protein sequence ID" value="RIE04736"/>
        <property type="gene ID" value="D3H35_04435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008726">
        <property type="term" value="F:alkanesulfonate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01229">
        <property type="entry name" value="Alkanesulf_monooxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019911">
        <property type="entry name" value="Alkanesulphonate_mOase_FMN-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013015">
        <property type="entry name" value="Laminin_IV_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03565">
        <property type="entry name" value="alk_sulf_monoox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51116">
        <property type="entry name" value="LAMININ_IVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0288">FMN</keyword>
    <keyword evidence="5 6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Laminin IV type B" evidence="7">
        <location>
            <begin position="238"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="372" mass="41399" checksum="16D99E4958802189" modified="2018-12-05" version="1">MELFWFVPSYGDGRYIGSGLGSRNASLSYYQQVAMAADDLGFHGVLLPTGRSCEDSWVLASMLVPVTRKLKYLIAVRPGLMSPTLAARMASTFDRHSNGRLLINVVAGGDPAELEADGIHLEHDERYALTDEFMTVWRELLQQQSVNFDGNHIRIKDAVNFYPALQRPHPPVFFGGSSPAAIDTALKHADHYLTWGEPLEQVAEKIAHVRARAEEEGRTIRFGIRLHVIVRETEDEAWAAADDLIRHLDDETIARAQQIYARMDSHGQKRMTQLHNGSRSNLVIGPNLWTGIGLVRGGAGTALVGSADNVAARIREYADLGIESFILSGYPHLEEAYRVAELLFPKLQLQSQQESSIPKGEIVAYHYKPDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN86</accession>
    <name>A0A398CN86_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_28560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00374">
        <property type="protein sequence ID" value="RIE00374"/>
        <property type="gene ID" value="D3H35_28560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017435299" evidence="2">
        <location>
            <begin position="31"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="454" mass="49597" checksum="894FB05D0AD6B826" modified="2018-12-05" version="1">MKKMKAIYPVMSVVLAAAALTACGSNNEKASPSAGSSESAPASASSSPSAEPKKDPVTLTFLIPNTDDVTPYNSIFAEFEKQTGNKVEVQALPGGDYDNMLKTRFSTGDFPDVFLMQPGTKQYVKLRADETLVDWSGEAGVWDDIIDSIKDFQKNTEGKAYGVPFGKTGQMGVFYNKDVFAKANVEPPKNYADLIEIAKKIKAAGVTPFYEAVKEGWPTQVFYLTGWVSQVDQAIGAEGVQKLNVNQAKLADIPELKDLFAKAKQLKDLGLYQKNALSGTYDELQNEFGDGKVGMIFMLDGILPQLEKKFGKDFLTDKVGFFPFPSAADTGTAMITPPNQLMVPSKAKHLEQAKELVKFMISKDSVNTFYASQPGIPIFKSATSELYPVQKTVQEYIDAGKSTVNVQNRLTASFLDLGKTLQTFHIKGDVDAALNEMSANYMKDGNSKRLEGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNB8</accession>
    <name>A0A398CNB8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation integral membrane protein YlbJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02739">
        <property type="protein sequence ID" value="RIE02739"/>
        <property type="gene ID" value="D3H35_19025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="422" mass="43542" checksum="51621A0D7D3FD890" modified="2018-12-05" version="1">MVAKTTKQPAFSGISRIGAMLAVGATAATIGGLALAMPHTALQASLRGVSVWWDVLFPALFPFFVLSELLLGFGIVHLAGTLMDPLMRPLFRLPGAGGFVVAMGFASGYPVGARLTSRLMEQGLVNREQGERLVAITTTSDPIFLIGAVCIGFFQTPAAIPVLAIAHYGGAILLGLIGRLGGSASKDLPIRAQPLRTHGAGRIKAAIAAMHHARLADGRPFGAMLQQSIQSSLALMFVVGGLVVFFSASLELLVNSGVLTPLKNAAGSILHLFGLPSGMSPSLVNGVFEVTLGARSAASSTEGASLLSMGDRLAAAAFILSWAGLSVHAQVAGLMGQTGWRYGPFARARLLHGVMAVVIAYLIWPYFSAAGSASYPTWATATRSAPDAFVWTLAAAAGTLALLAAAGAVALAVDKLSGRKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNR6</accession>
    <name>A0A398CNR6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_19985</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02899">
        <property type="protein sequence ID" value="RIE02899"/>
        <property type="gene ID" value="D3H35_19985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="135"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="135"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="242" mass="27116" checksum="AF89BCE1886D7869" modified="2018-12-05" version="1">MSDKVLIIEDEPTLARLVTYNLSQEGYETEVVGNGAEGLHRAIHDTYAIIFLDLMLPGMNGFEVLQKLRQNHVKTPVIILTARNAEEEVVQGLKLGADDYITKPFGVAELLARTSAVLRRSRNEENKPTAGSAGDKVIALGDLQIFPDKYEVFLNGQWITLRPKEFEVLLYLAERPGIVITRDDLMNVVWGFDYIGGQRTVDVHVSSLRKKLELNQQTVQIESIRGVGYKLIVNRKTNGPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNV6</accession>
    <name>A0A398CNV6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LPXTG cell wall anchor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00594">
        <property type="protein sequence ID" value="RIE00594"/>
        <property type="gene ID" value="D3H35_27820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="53" mass="5443" checksum="55C6E209BF44D695" modified="2018-12-05" version="1">MGVYRALTGLSCGSASACHAPFPNTGGTAGELTLSSLTMFVGGGSFFICRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNZ1</accession>
    <name>A0A398CNZ1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_06630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04283">
        <property type="protein sequence ID" value="RIE04283"/>
        <property type="gene ID" value="D3H35_06630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="52"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="417" mass="45638" checksum="D5828BCBBEB3DA17" modified="2018-12-05" version="1">MSVEKYQSTFIQEQFANRIGGSNYGKDTNIYKFEKIKRAKAAAKLAHPDLELIDMGVGEPDEMADGGIVAKLAEEAAKPENRGYADNGIREFKVAAAQYLKEVFSVDGIDADTEVLHTIGSKPALAMLPSVFINPGDVTIMTVPGYPVLGTHTKYLGGEVYNIKLTKENNFLPDLEAIPVEIAERAKLLYLNYPNNPTGAAATAEFFVKVVAWAKKYNVVVVHDAPYAALTYDGVKPLSFLSVPGAKDIGVELHSLSKSYNMTGWRIGFIAGNPLIVKAFGDVKDNNDSGQFIAIQKAAAYGLANPAITEAISAKYSRRHNLLVGALNELGFKAEKPKGSFFLYVEAPKGIKGGQRFESGEDFSQFLIREKLISTVPWDDAGRFVRFSVTFIAQGEAEELRVIGEIKSRLSDVEFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP10</accession>
    <name>A0A398CP10_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D3H35_23060</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01271">
        <property type="protein sequence ID" value="RIE01271"/>
        <property type="gene ID" value="D3H35_23060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="147"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="214"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE01271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="436" mass="48470" checksum="FEAAC65244F430FD" modified="2018-12-05" version="1">MERLNENRLGAARLWRDPSVRRLSLWLTGLFVVVAISVWLFAYLSAERMKADWIDEQTELIGKLALTDPDKAEEWARALAGSLESPASKAAIEEGQRLVSRYGITPAIDSRMIPASHSYYTRTLAAAGLGAVIFAMLAAIIMLRESRRGLIQISRLARSVEDTVKHNKPMAFRLYGEGELGLLANSVQELAIRLQETIEQLEQDKTFLKNMVADISHQLKTPLASLIIYVDLLREGKTDSVSSAEFLDTCRRELDRMEWLTLTLLKLARMEAGALDMQMRTGDLADTLRKAIEPTRRLAEERAIDISVVEPEEPIYCPHDSHWLAEALQNVIKNAIEHSPAHSRVTIRSEQTSVFIRITVTDSGQGIDERHLPHIFKKFYRASRGGSGVGLGLPLARIIAEKHGGLLSARANAGEGSTFTLTLPANGSVPFLLTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP20</accession>
    <name>A0A398CP20_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_23125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01281">
        <property type="protein sequence ID" value="RIE01281"/>
        <property type="gene ID" value="D3H35_23125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="78"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="308" mass="34305" checksum="91AB2879D7553FC7" modified="2018-12-05" version="1">MIRKNTSTLSRWKKAAVHLFPVPALAVYIAFIVVPIVTAFGYSLYDWKGMNKGEFIGLGNFKTLFTMEPFNTMFWRAFGHNLYLFAFKMIILNGLSFILAYIIYTKIRGAGFFKIAFFLPRLLSVIVVGFLWKMMLNPNNGIVNVFLKKVGLSDWTMPWLGDTRTALSSIATANVWFDLGFFVLLFLAGLQSMSSEVIEAAKMDGAIGIRLFRSIILPLIKPSLMIIVVLTFIHSFEAFELVYAMEGSSGAPVYSTDLLAVYFYRIAFGGSSADVVAVGLGSALAVVLFFIIALLSSLSLFVFRKEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPB7</accession>
    <name>A0A398CPB7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05246">
        <property type="protein sequence ID" value="RIE05246"/>
        <property type="gene ID" value="D3H35_01620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="9"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="128"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="242" mass="27245" checksum="BFBE6AAA9F7A1939" modified="2018-12-05" version="1">MTVALNISALHGIYVTVADARRSAEWYASCFGMTESDYGSYCGIRLSEGSSIVLVESAIRNVYESSPFHFKCNDARRAHGELAKRAVKATEPVNWHNYVDFCFWDPDGNPVGVISDPAWSPHANNYFRTDGLFLGSARFESTLDWYLNLFGTEIEYDFTVATTSSPEARMCCLRGVPFTLFESPAGEIHHRFCDFRTSNAAADYAYFLEKGVRVTPLLSSTKRKSFSFFDPEGREFGFLEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPQ2</accession>
    <name>A0A398CPQ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_05785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000026">
        <property type="protein sequence ID" value="RIE04515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04515">
        <property type="protein sequence ID" value="RIE04515"/>
        <property type="gene ID" value="D3H35_05785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="74" mass="8449" checksum="AC381198DF22D423" modified="2018-12-05" version="1">MSASVITNAKWEDNRAAVEAKDTKWIKENVDVSKGIIPNVHFVVTLDNDGMCSHRREILRNLRKKSLSASYFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPZ2</accession>
    <name>A0A398CPZ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01034">
        <property type="protein sequence ID" value="RIE01034"/>
        <property type="gene ID" value="D3H35_21525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="127" mass="13991" checksum="8D80695278B89D92" modified="2018-12-05" version="1">MVNYGLTPASYSNDLKVGDPLKTNHLANVIAGGMKRINPEALNKNENSIRSLYVKSNDTLLTRDQAAKYLITAFSNEKSGANDWDSALRLKLIDKTTHDKIAKERTLTKAEGYAIAAGLLSKFVIQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ03</accession>
    <name>A0A398CQ03_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_03675</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04605">
        <property type="protein sequence ID" value="RIE04605"/>
        <property type="gene ID" value="D3H35_03675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017263963" evidence="9">
        <location>
            <begin position="31"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="10">
        <location>
            <begin position="34"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE04605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="395" mass="43112" checksum="4F4056C640B71B9A" modified="2018-12-05" version="1">MRTVRISRVIAAALSAFVLTGTILSTAAHAEPANAPQAPENHARGAALVDVESGRVLYSKRGDSRMLIASLTKIMTAIVAIEHGKLADKVTVSTRAAGKEGSSIYLKAGEKMTLQNMLYGLMLRSGNDAAVAVAEHVGGSLDGFVYMMNKKAEELGLSNSHFANPSGLDQEGHFSSAVDLAKLTAYALHNPVFREIVKTRVKSAPNPHEDWDYKWVNKNKMLTMYEGADGVKTGYTKQSLRTLVSSATRNGQQLVAVTLNDGDDWADHRRLLDYGFLYYPLAQVVAKGQPVNDHPYAVDGDFRYPFAKGERERLRIKLVPFDRASADYLLGKKGRLRLMLDGREIGSVDLTGRALADEETGETPTDAVVHSASAGRRTFYSALQECAGWLFFGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ16</accession>
    <name>A0A398CQ16_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_14225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01927">
        <property type="protein sequence ID" value="RIE01927"/>
        <property type="gene ID" value="D3H35_14225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017431659" evidence="6">
        <location>
            <begin position="33"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="7">
        <location>
            <begin position="64"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="359" mass="37850" checksum="0D1FA620C61A2F3D" modified="2018-12-05" version="1">MKNVLSHKRLWVSSAAVLVAAGVLSGCGDSNNKDNASASPSAPASGSSSAAAAQAAGGAKALKKVTFAYAGGTCEAPIYAAIEKGFFKEEGLDVTLVQQDFETLKSGIASGKVDGTVGNFAWFKPIEQGLDVKLTGGLHAGCIQLVAPGDSGIKSVADLKGKIIGVDVIGGGPQITLSIALKQQGLDPQKDVEWRAYPSQQLATAAEKGEIAAFIVWDPAAQQAIDDKKYVRLLSNGHDEPFKSGYCCYSVISGKVAEEDPEKAASITRALLKAAEWVGTNAHETAEIETNKKYVSADAATNEKLLAGYHWKPGVKSAQESAKFFIKYQKELGILDASTDETELYNRVFFAAIPDFNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ17</accession>
    <name>A0A398CQ17_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_21865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01074">
        <property type="protein sequence ID" value="RIE01074"/>
        <property type="gene ID" value="D3H35_21865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="310" mass="35484" checksum="13DB00A6F058CC68" modified="2018-12-05" version="1">MKLGFYGNYTPETVKFASEVGFKCMELSAWPKSSLNADTISDRRIEEIQQDLQAHDIEISTLGYYPNFLDPNKAHSDEAQRYFIKLLDLAVKMNVRTVSTFAGRHPGLSVEKNIPLFKEVFSRFCEEAEKRNIRIAMENCPMMNHVTSEGLNIAYSPEIWQVLFDAVPSDHLGLEIDPSHMVWQGIDYVKAIHEFGHKIFHAHAKDMEILHDVKARSGQFGTLFRNIDDLGHGWWRARTPGWGDVKWDKYITALIEVNYTGNIDIEHEDDVFAKTIDMGEITEESDIVNNYVQDRNGLILGYKTLSALIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ30</accession>
    <name>A0A398CQ30_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketopantoate reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01541">
        <property type="protein sequence ID" value="RIE01541"/>
        <property type="gene ID" value="D3H35_24635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="1">
        <location>
            <begin position="9"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="297" mass="33424" checksum="75BB2BB30EB44EFF" modified="2018-12-05" version="1">MNTKPYRLLIFGAGVVGSVYALRFVQYGLDVTLLARGKRLEALKRNGLSYNDNGTVKQISVKTIDTLENDDIYDFIFVPVRYDQAESSLTAIKNNKSKTIVTLTNTIGYDSWLEIVGDRLLPGFPGAGGDIKEDVLYAQFGSEKHQGTIFGEINGRTTERVKELAQLFESVNLHYEIQKDILAFHISHIALAIVNKHFYTNDGMVDIETARSIKILSKIAADIKQNLHLVEQAGIPVIPPETKAMGELPENDIISRYRQWLSNDFIIDVKLGNHAISQKAEIMLLDKMFHELLSTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ79</accession>
    <name>A0A398CQ79_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NADH-quinone oxidoreductase subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_14670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02007">
        <property type="protein sequence ID" value="RIE02007"/>
        <property type="gene ID" value="D3H35_14670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="9">
        <location>
            <begin position="148"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE02007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="542" mass="58797" checksum="AEEA609E5378A374" modified="2018-12-05" version="1">MLDSFPVLSFIVLAPLVGALIIQFMPKQRSSWIRGTAVLFTLIPLALTLWLFAAYEPGTGGSSYTEHATWLSIPLNTELRLQEQGVLSLKLLFDYHLAVDGISLPLLFLTAIVATMSALASTHIRKRWKTYYSLFLLLEAGMFGVFLARDLVLFFVFFELTLIPMFFLIGIWGYFGREKAANRFLIYNGLGSAAMLLAFLMLIATLGFGFTETANGAHLTFSGNYDVLLHNASDPQALANVTVEQGGIAGFFLSDPMKWSALLLLLFAFGVKIPIFPFHTWMLRVHTEAPPPVVMIHSGVLLKMGVYGLIRFGAFLLPAQMESMTTALAVLGVVNILYGAILACVQKEFKLVLAYSSISHMGIVLLGIASLNEIGLQGALYQSISHGLISALLFLLVGCLYERTGTTELDQLGGLARSVPFLSGILLVGGLASLGLPGLSGFVGEFLSFLGLFGSMKWLTAIGVLGILFAAVYILRSILSITYGPLPEKLKGIQDARFIEAVPMVALVALIVLLGVYPSILTNLMQHGFHGLVEQLQSRSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ95</accession>
    <name>A0A398CQ95_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_20240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02938">
        <property type="protein sequence ID" value="RIE02938"/>
        <property type="gene ID" value="D3H35_20240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="269" mass="30288" checksum="A5D9F4866EE9C942" modified="2018-12-05" version="1">MGYWSGERVSGGNSRQWLGYWSGERVSGGNSRLWLGCWSGERVSGGNSRLWLGYWSGERVSGGNSRLWLGYWSGERMSGGNSRLWLGYWSGERMSGGNSRLWLGYWSGERMSGGDSRLWLGYWSGERTSGGDSRLWLGYWSGERVSGENSRLWLGYWSGERTSGGDSRLWLGYWSGERTSVGSSRLWLGYWSGERTSEGNSRLWLGCWSGERVSGGNSRLWLGYWSGERTSEGNSRLWLGYRSGERMSGGDSRQWLGCWSGERMSGGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQA7</accession>
    <name>A0A398CQA7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavodoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_22435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Low-potential electron donor to a number of redox enzymes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01164">
        <property type="protein sequence ID" value="RIE01164"/>
        <property type="gene ID" value="D3H35_22435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010087">
        <property type="entry name" value="Flav_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001226">
        <property type="entry name" value="Flavodoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01753">
        <property type="entry name" value="flav_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00201">
        <property type="entry name" value="FLAVODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="159" mass="16949" checksum="70F3E2C4807A70FA" modified="2018-12-05" version="1">MANVLLVYASMTGNTEEMADAIAEGIRAAGGTLTVKMVMDAQAAELSQYAAVVLGAYTWGDGELPDEFLDFYEAMNDLNLSGVKSAVFGSCDSNYPEYGVAVDILIERLKARGSDVVLEGLKIEFAPSEDEKEVCRQFGEQLVRSARGDGGEIPHGSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQB1</accession>
    <name>A0A398CQB1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_25035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01611">
        <property type="protein sequence ID" value="RIE01611"/>
        <property type="gene ID" value="D3H35_25035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="371" mass="42295" checksum="3967F274DA5ECA15" modified="2018-12-05" version="1">MRVLIVDDEPAMLLAMKRLLASMDGVELVGSFRSAQEAADFVRDGDVDLAFLDIQIGADDGLELARSLRSVRADLDIVFTTSHAEYAMDAYDVYPLDYMVKPISRKRLSQTIARAAARRSAASDDTGGHEPNRLTVRGLGCFEASSKQAGVVKWISKKSTELFAYLLVNRGRSVSKDRILEAVFPGMPLKNAEIYLNTAVYQLRKALSAHGFKEIVVSAQEQYRVDLDQADVDFIQFAQGAEQLSEINEANEADAIELEKQFAGDLFEDRSFEWATMERERLAILYVSLAKRLADWLLAQKRYREAAQMARRMVSRNEFEEESNLLLLNILGAMGDRQELYNHYERYTKWLLQELGVQPSEEFRRIYEQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQK8</accession>
    <name>A0A398CQK8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04450">
        <property type="protein sequence ID" value="RIE04450"/>
        <property type="gene ID" value="D3H35_07650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="85" mass="9320" checksum="1CC9419F00B79AA7" modified="2018-12-05" version="1">MGEEKPDEELMGKRKSSPRLSPTPLGAGTIIVASGAGNIHGLEKKMERFAKPRGRTSFASFRFVVTYTHIKAARSGCRQRNVCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQS4</accession>
    <name>A0A398CQS4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01284">
        <property type="protein sequence ID" value="RIE01284"/>
        <property type="gene ID" value="D3H35_23140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="136" mass="14752" checksum="226977E04AF30EA6" modified="2018-12-05" version="1">MEKHVRQVVSEMLTAGYEANRQLAFYFDPAAEHTERDWEGRADYPLLHLFGKPGSLCGLSLKQTSATALDRGSIRFVPTAEFDNGLKITPLGGQYRVDDPGVASVEETGVVVPIQSGAASGAYSFNGMEAPFQIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQS8</accession>
    <name>A0A398CQS8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_05200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04862">
        <property type="protein sequence ID" value="RIE04862"/>
        <property type="gene ID" value="D3H35_05200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="86"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="309" mass="35086" checksum="2DB75DFA47679DA0" modified="2018-12-05" version="1">MFTLTGMGRGEDTMLTRKFIKSYGFGYLLLAPAVLYLVAFQFYPLFETVRLSLFDYSLISNRAMSFIGLDHYTYFLTEDDRFWKIMRNSLVWVIGSTVFQFAVAIPAALILNAKIRSRGLWRGLMMVPWVSPVVIIGIVWKWIYDGHNGIANHYLSEWGIIRESIVWLGDDFWVWPALLLTSVWKGFPYIALMLLSGLTGISKEMMEAAEVDGATGWQRLVRIVLPLLKPIMYVTGMVSIVSSWTKFEMIWALTNGGPGFETSILPTYVYTNAFVYYDLGRGSAIATLSMLFVLVLVAIYAGLFGRDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQS9</accession>
    <name>A0A398CQS9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine diphosphokinase</fullName>
            <ecNumber evidence="1">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_04765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.2" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04905">
        <property type="protein sequence ID" value="RIE04905"/>
        <property type="gene ID" value="D3H35_04765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="SSF63862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="SSF63999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPK_B1_binding" evidence="6">
        <location>
            <begin position="148"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="220" mass="24288" checksum="C8DE932AE86E6FA8" modified="2018-12-05" version="1">MNHSERQPSERAVIFTGGRLGSWAFPHIGDSDFLIGADRGASFLVEHGYAPDLALGDFDSVDANQMTRIRQSAKELLIFDAIDKDWTDTELALNEALSRGYRQIAIIGGLGTRFDHSLANVHLLRQAVSVGCDASLIDEHNEIFLCTSECRLPQDERFPYVSLLPLTSEVTGIELQGFQYPLHNATLRIGWTLGISNVIAENTGVVKIDSGELFVIKSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQT4</accession>
    <name>A0A398CQT4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3048 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_16830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03158">
        <property type="protein sequence ID" value="RIE03158"/>
        <property type="gene ID" value="D3H35_16830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.90.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035328">
        <property type="entry name" value="DUF3048_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021416">
        <property type="entry name" value="DUF3048_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023158">
        <property type="entry name" value="YerB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11258">
        <property type="entry name" value="DUF3048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17479">
        <property type="entry name" value="DUF3048_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159774">
        <property type="entry name" value="SSF159774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3048" evidence="2">
        <location>
            <begin position="77"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3048_C" evidence="3">
        <location>
            <begin position="249"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="371" mass="39783" checksum="B35874075B6920F2" modified="2018-12-05" version="1">MPQSALSGKPQLAPLVRRIPLAIAALTLAVAGLTACGGDSKPVNAPPSASSSGAPTESASPAPSESSSPALAFTAPLTGLPIEQPVNKRPLTVMINNLKPARPQSGLSHADMVWEILAEGGITRLVGFFQSNESSDPIGPIRSIRPYLIELGQIYGGVLVHAGASNDALAILQRNKKIPDLDEINNAGAYFYRDKSRKAPHNLYSTAEKLRAGAEHRKIETNVPLPQLIFDSNPDLSGAAPASEIGIKFELSDYKVSYTYDASASKYKRSINGQPHVDKNNNEQLTATNLVVIATKHKTYDSYGRLEIDLNGGGEALVFQQGRVISCTWEHSQGDAVRLMKDGKELPMIPGVTYFHVVPNSKPISSHVTYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR26</accession>
    <name>A0A398CR26_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_13955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01881">
        <property type="protein sequence ID" value="RIE01881"/>
        <property type="gene ID" value="D3H35_13955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017427749" evidence="2">
        <location>
            <begin position="33"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="596" mass="66194" checksum="589096ADC1A59B63" modified="2018-12-05" version="1">MNKRTITLAISIALVFSLILAACSSKNSDNKASPSSKATMTQEASPPASTSTPEPSPTGFEFHKYDTPIQLTFHTLVGADSKWRDGESFENNAFTRWAKDELGIEWKTKFLSPTFDDSKTKLNLGMASNELPDAIFSDTAQLGVLAGQGYLAPLNELIEKYGSPLVKDRLKAAMEASGGKFLSPYTIDGKYYALPIDVEMWGRTYYNTFIRQDILDSLGKQVPQTLEQFEDVLAAYKAKVPDGIGVFLHKDLVPDGVNQMSPAMQPYNAYPGRWVVGADGKLAYGSIQPETKKGLETLNKWFKNGWLDKEFIMKDFNKALEQVVAGKVLSITGDWWYAYYPLPDVVKNVETAKFSATSLQGPDGKARLVTTNPFSLAIGISSKSEHPEAFIYQLNEMMDSALRQDSALRDRMKNEYGYEFKYPVESANSQIAKNPEAPQEQQDFDVVKPGPMFFRTSIKTKFFGGFQWVGDVDKGLNDLVAVANAVDKGNKDGLSLSQQQMLNDLTNNKTIDALVSEVHQAQSIRSDMVIDGFTGAPTPTMIEKGAYLKKLENEIFAKIIFGSKPIDDFDKFVSDWKKAGGDQITQEVNDWYAKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR36</accession>
    <name>A0A398CR36_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3900 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_14010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01891">
        <property type="protein sequence ID" value="RIE01891"/>
        <property type="gene ID" value="D3H35_14010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025012">
        <property type="entry name" value="DUF3898"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025006">
        <property type="entry name" value="DUF3900"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13037">
        <property type="entry name" value="DUF3898"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13039">
        <property type="entry name" value="DUF3900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3898" evidence="2">
        <location>
            <begin position="273"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="392" mass="45407" checksum="910F3CA2E66D7C29" modified="2018-12-05" version="1">MKFTVQYLSFFVIHTDQSDSNASKKYKHYQTLTHEEYQDSEIKAFLDDEFTRIGKRKVEVNPISASVPTKVGRFIVEPGHDLTSNPNFNLFQRLRTAQDRQQFHHFGDDLLRTYMDASAVRGGAFIVALARHEKLFDDPFVFMLKCDFESSIARISDERSLISKVEMAISSRNIKSIQYPHMPEEGMLEEWELKVHQASHARYFEDFLKYVSYEKSKPEIVSDQVMEMVHEFIETKWEAVDTSNLPMERREYEDWAAAEKRDIEVWAASEKRELQQKWSHDQVVEAATRIVEHQPELEMKFKLDEVAVRGPLSEYGGKLHIARLNGRYVVLIEGDHFQFDRGVSPIELLHPEDFEQVVERIRLNAEAGEQTGEQAGGYGSYGGGRGSDEAPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR44</accession>
    <name>A0A398CR44_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dipeptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_02550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05035">
        <property type="protein sequence ID" value="RIE05035"/>
        <property type="gene ID" value="D3H35_02550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="11"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="362" mass="39966" checksum="69FA9F67DB875C5D" modified="2018-12-05" version="1">MTTAPKSKPLLEVRNLTKHYRGGSAFSRNAPVVKAVNGVSFQLYEGETYGLVGESGCGKSTLGKTILRLQEATDGEVVYRGRDLLQLSVKQMRGVRKQLQMVFQDPYTSLNPRRKIGKTLEEALIIHGVRSREERERRVSDMLERIGLRPEHGGRYPHELSGGQRQRIGLARALILNPQIVVCDEPVSALDVIIQSQIINLMKRLQRELNLTYLFIAHDISVVRYISDRIGVMYLGKLVEEAETDALFASPRHPYTKVLLSAVPTPSPGKAKERVKLTGELPSPLDIPSGCAFHTRCPYATEICRKEEPPLRSLAHNHTAACHHAEALAAAAGESDSVLDGRYARDLSGSAFEEPAGATIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR84</accession>
    <name>A0A398CR84_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02337">
        <property type="protein sequence ID" value="RIE02337"/>
        <property type="gene ID" value="D3H35_16600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="163"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="222" mass="26180" checksum="A1769B26BE5869C5" modified="2018-12-05" version="1">MFENRHAEWIERQAKNRSGESLRRLREGHSHNEKLFAEQIWWPVIGSFECLLAEHEVRNYRDGSYFLDFGYVRPPYKLDWEIDDFSSHAKNINRRNFDYEKERQNQLMLDGWQIYRFSLDAIKERPRHCQQFVLQVLGKLYGGASSQPNDIPLTSQQRDIMRMAAIVRRAITPSEICRTMNVHPQTARKRLSELVQAGLLEPASGDIRVRAYKLGPKAAQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS61</accession>
    <name>A0A398CS61_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RHS repeat-associated core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_11110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03578">
        <property type="protein sequence ID" value="RIE03578"/>
        <property type="gene ID" value="D3H35_11110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="120" mass="13728" checksum="9D6EF14AD8016AD9" modified="2018-12-05" version="1">MLPERPLIPMTTTFGEYHKPNGRDVQPFKYTGEIQDDESGLIYLRARYYDPSIGRFINEDSYEGQIDNPLTLNLYTYVGNNPLIYSDPSGHFWETIVDVMSIGWSAVDLWNDLVGVMQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSA8</accession>
    <name>A0A398CSA8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000006">
        <property type="protein sequence ID" value="RIE05412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05412">
        <property type="protein sequence ID" value="RIE05412"/>
        <property type="gene ID" value="D3H35_00555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="82" mass="9151" checksum="476B21EEAE8496C5" modified="2018-12-05" version="1">MDTSGFMTVGTSLERDIYEIGSHLASLARSAPHVEPASTFRDVAQPVQREYVRGATYHFERMKGIAAAFDSKLDDDELDFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSF1</accession>
    <name>A0A398CSF1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma-W factor RsiW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_05965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-associated anti-sigma factor (ZAS) superfamily. Anti-sigma-W factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04169">
        <property type="protein sequence ID" value="RIE04169"/>
        <property type="gene ID" value="D3H35_05965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="5">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="331" mass="34915" checksum="95C17CECC5CF4169" modified="2018-12-05" version="1">MICQEVMELMQRYVDDDLNEQETSRMMSHVEECPDCAAMLERLRRLSDGLMQLPKVTPPFSLVDAILPQLELQAVGTVRGEDSGSASVTDAPTPLAETRSSRPRRGLFGRIAGVVALGLAIGAMLYNQPFPFGTSGSQNNSEAAMPKESSAQSFKMSDQIGAADDMVAPLTAGAPTPSAEEAPAPLVENGPAPSVGTKHKNEARQGIAETEADKKSFAPESAQPAAGQETDSAGGGQMKEAPSLKSLGSSPGDMGQSPDGKWMTIASADGLLTVIKAEDGSTVFATPVRYGMPTGLSWNADSTQLSYTFADENGKQTNYVYDVTTGKESTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSS2</accession>
    <name>A0A398CSS2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_01435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05210">
        <property type="protein sequence ID" value="RIE05210"/>
        <property type="gene ID" value="D3H35_01435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015716">
        <property type="term" value="P:organic phosphonate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017797">
        <property type="entry name" value="Phosphnate-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30043:SF1">
        <property type="entry name" value="PTHR30043:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="74"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="269" mass="29274" checksum="0CED6D3D8E249AD8" modified="2018-12-05" version="1">MEKKIIVRPFNRSKLVIWLTVAGLALLTVYGFLTFDYKDIDLGEATSSMAATVKSMFLEPHLKHITFVEAIKALSVTLGLAFLTTLFGAIIALMLGLLASRNLVPGPVVAVVRGISAFIRAVPTVLWVLIFAVAAGLGSVAAVIGMTFHSVSYLVKAYSASYEELDDGVIEALKASGANWWQIVFQAVLPSSVSYILSWTFIRFEINFAVAVAMGAAAGAGGIGFDMFMASNFYYDVREVGMFTYLILAFAILLEVFATRMKRKLRLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT17</accession>
    <name>A0A398CT17_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe/B12 periplasmic-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02461">
        <property type="protein sequence ID" value="RIE02461"/>
        <property type="gene ID" value="D3H35_17330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="217" mass="24385" checksum="54330BC7E20F9142" modified="2018-12-05" version="1">MHGGNGRFDLENATLLKPDLIILDKEDEEEYERISAIAPTLTYNSFDSLQERLTTLGRWLGKEKEAQQWLDRHAASLEAMWKKLGAFIREGETAAVFVHHRGKQLFVMGTIGLTTVLYHPDGFRPTGQVKAMLNAKMAYKEITLDDLQSYAGDRIFMLLPSSPVSRSALEETLQSPLWRDIPAVKNGLVHMVDELTWNCGDANTIGRLADKLSKLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT34</accession>
    <name>A0A398CT34_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_00030</name>
        <name evidence="9" type="ORF">D3H35_01240</name>
        <name evidence="8" type="ORF">D3H35_08935</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000011">
        <property type="protein sequence ID" value="RIE05320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000001">
        <property type="protein sequence ID" value="RIE05483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04062">
        <property type="protein sequence ID" value="RIE04062"/>
        <property type="gene ID" value="D3H35_08935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05320">
        <property type="protein sequence ID" value="RIE05320"/>
        <property type="gene ID" value="D3H35_01240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05483">
        <property type="protein sequence ID" value="RIE05483"/>
        <property type="gene ID" value="D3H35_00030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="7">
        <location>
            <begin position="128"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="128"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE05320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE05483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="228" mass="26199" checksum="B45A701C7C93AEF8" modified="2018-12-05" version="1">MRPHIVVIDDDDKITSLLRRSLAFEGYEVTTAHDGADGIRLLGEKNAELIILDVMMPKLDGWEVCRRLREAGISAPVLLLTARDEVQDRVKGLDLGADDYLVKPFALEELMARVRALLRRRPERAEEDGRLRFEDVTLDYDGRETIRDGKRIELTAKEFDLLHLFMQNPKRVLSRDQIMERIWGYDYSGESNVLEVYVAMLRQKMEEHGGKRIIQTVRGAGYVLKGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT37</accession>
    <name>A0A398CT37_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 18" type="primary">uvrB</name>
        <name evidence="18" type="ORF">D3H35_15305</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02124">
        <property type="protein sequence ID" value="RIE02124"/>
        <property type="gene ID" value="D3H35_15305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="32"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="436"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="15">
        <location>
            <begin position="630"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RIE02124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="666" mass="75402" checksum="FA0EE4754150F777" modified="2018-12-05" version="1">MAADNERQGTFHLVSEYSPQGDQPEAIRQLAEGIVKGKKHQTLLGATGTGKTFTIAQTIAKVGKPTLIIAHNKTLAAQLCSEFKEFFPDNAVEYFVSYYDYYQPEAYIPSTDTYIEKDSSINDEIDKLRHSATSSLFERRDVIVVASVSCIYGLGSPEEYRDLRLSLRTGMERSRNAILHKLVDIQYQRNDLNFIRGTFRVRGDVVEIFPVSRGDRAIRVELFGDEIERISEIDVLTGEVLGEREHVTIFPASHFVTAEEKMKLAMVDIEKELEERLAELREGGKLLEAQRLEQRTRYDLEMMAEMGFCSGIENYSGPLTFRERGATPYTLMDFFPDDYLIVIDESHVTLPQVRAMYNGDQARKSVLVDHGFRLPSAKDNRPLKFEEFEKKAKQLVYVSATPGPYELELCPEMVQQIIRPTGLVDPVIEVRSTKGQIDDLLGEIRTRVAKDERVLVTTLTKKMSEDLTDYLKEVGIKVRYLHSDIKTLERMAILRDLRLGTFDVLVGINLLREGLDLPEVTLVAILDADKEGFLRAERSLIQTIGRAARNSEGRVIMYGDKITDSMEKAIGETERRRAIQTAYNEKHGITPQTIRKKVRDVIEATKVAEAKASYLTGADNIGKLSKKDRIGVIERLEAEMKEAAKSLQFERAAELRDALLELKAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTF4</accession>
    <name>A0A398CTF4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02591">
        <property type="protein sequence ID" value="RIE02591"/>
        <property type="gene ID" value="D3H35_18075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="198" mass="22188" checksum="6CB0297C33D5B31E" modified="2018-12-05" version="1">MTFLELFAWLSEMQQYYLSRVPDRNYYKFLDLLGVEKREAVSAVTEASFDGVRERLLLPRGTKLLADDQLFETADAIHLLPLAIERIVVRTEREASDMTASNTGGNTAFFAFGREAHAGSRFYVAFDQEPEVGETVTLSIRLATTGKLRLTSGRCFLLPRFHGKPTASRKLRGRHGFLSTSLATIPYICRSADGLLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTZ8</accession>
    <name>A0A398CTZ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02791">
        <property type="protein sequence ID" value="RIE02791"/>
        <property type="gene ID" value="D3H35_19335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="111" mass="12227" checksum="F982BDFAEB108574" modified="2018-12-05" version="1">MPKEWGGLMKRLLNRLPPVATIILALVFCFANPYTSKALNGSTVVIIFVALILPAVLVLISIPFRNNMLKSIGFCLSLPCGLYLGLAGIPSYWALIIVFIAFYPFIKIRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUC8</accession>
    <name>A0A398CUC8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_05240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04869">
        <property type="protein sequence ID" value="RIE04869"/>
        <property type="gene ID" value="D3H35_05240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="274" mass="32279" checksum="8B4ABE120F47CC53" modified="2018-12-05" version="1">MKSDHEFYSTRKGIEKDKLNLMDLTEVFQIILHELTQERYFATFYGDNDNFDNWTPGIAGRNFEAYCLSVIGRRIKDPFYQDSLKYSETDLFDLIELLHRNIELKWSIAFSKFEFESIEQAKEHSQSVFRDKINKQLSRYGIGWELTRESFIREIIATELSELIDNIAAYGDEENVDNRIRRAIKEFFRYGATDLSKKGALIEIGGALEIIRKEIESALPIEEAAIFTILNNFDLRHNRKLKTSGYDTSIYYPWMLYTFLATFEAFVKIRQRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUG5</accession>
    <name>A0A398CUG5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03497">
        <property type="protein sequence ID" value="RIE03497"/>
        <property type="gene ID" value="D3H35_12680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="74" mass="8409" checksum="B4FDD329FCF7C37D" modified="2018-12-05" version="1">MLEKAFEQGTEPVGVIYDLKFTGMRPARTSRLRRFGARIHRLAGASSASLFRPRRIDAAFEKLCRTGLRRKNDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUN5</accession>
    <name>A0A398CUN5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02704">
        <property type="protein sequence ID" value="RIE02704"/>
        <property type="gene ID" value="D3H35_18790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="43" mass="4365" checksum="DA1AF8B3AF82328B" modified="2018-12-05" version="1">MPKQVGAAVSIVGALVIGQAATSAELSPRLWSSSSPLQESPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV21</accession>
    <name>A0A398CV21_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trehalose utilization protein ThuA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03727">
        <property type="protein sequence ID" value="RIE03727"/>
        <property type="gene ID" value="D3H35_10560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009381">
        <property type="entry name" value="Trehalose_catabolism_ThuA_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030013">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThuA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="241" mass="27411" checksum="C83CDD1132398AB8" modified="2018-12-05" version="1">MIRVTIWNEYVHEVVNPAVAEVYPQGIHNAIAAGIRNESFSIRTATLAEPEHGLTEEVLNETDVLLWWGHRAHDEVRDDIVDRVQQRVLDGMGLIVLHSGHCSKIFNKLMGTKTCQLKWREADEKERLWVIDPSHPIAEGIGEFIELPKEEMYGEHFNIPVPDELIFISWFEGGDVLRSGVTYSRGRGKIFYFRPGHETYPTYYNNDILKVISNGVKWAAPSQTAAPFYGNTAPLEPIKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV24</accession>
    <name>A0A398CV24_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05129">
        <property type="protein sequence ID" value="RIE05129"/>
        <property type="gene ID" value="D3H35_03120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="99" mass="10839" checksum="44353E8571298778" modified="2018-12-05" version="1">MVESYGTDGFGNVKTIQNGSATRTFQYDALNRITSETASSGQLTYTYDDMGNRSSLSDSGAVPSAPQVSRVSPPIRRRISLQLTQTMGFLRNIRTIQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVG5</accession>
    <name>A0A398CVG5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02994">
        <property type="protein sequence ID" value="RIE02994"/>
        <property type="gene ID" value="D3H35_20545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_11" evidence="1">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="93" mass="11208" checksum="78AD66ADB7CE4B65" modified="2018-12-05" version="1">MKLLLRGCRTVLSDSYRVPSLDIKRKDDLLSLLWLLTSNEKMTAERLADKMEVSVRTIYRYVEVPYIRRDVWSRAHQWDEVPYIRREVRSNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVG8</accession>
    <name>A0A398CVG8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000013">
        <property type="protein sequence ID" value="RIE05299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05299">
        <property type="protein sequence ID" value="RIE05299"/>
        <property type="gene ID" value="D3H35_01355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="452" mass="51199" checksum="E08575427D9A501D" modified="2018-12-05" version="1">MIKREFRYIELAGKLRTEILSGYLKPGQFLLPEKELCQVYDISRNSLRQALELLTNEGLLVKMVGRGTMVTKDLDIGKHESNIINIICPQHSSYVNKALPILIEMFKEQYPNVEFRLFGMGTNNEDLLQDLASFGVHADIVIMNDGDMQRLPLDKFLTLEDIVPEQGMTQDKLFQIFGHPTGQYAIPLTYSPVFLACNPHLFETSGLHIPQISWNWEQFVEAAKSITRDSNGDGLNDIYGFGLSSSLYRWPVLARKHSYRMRQEPSGMLNTEGLAGFLDFIQTLLYRDGVSPVMAVNDWELLAQLFDEGRLGMFLTTTLTTGMNNATFPVTVIPLPTSPQAVKGNLAIANGMMIPKTSGNTALAKQFARLAIHIDYQRRMAAEAKFLSVYTQVNEEVWTERERSALGVTEENSEPFYFMNEMLPDPILESALVHELSKFWQDSKHRTKRPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW18</accession>
    <name>A0A398CW18_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Polyphosphate kinase</fullName>
            <ecNumber evidence="6 7">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-polyphosphate phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Polyphosphoric acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ppk1</name>
        <name evidence="6" type="synonym">ppk</name>
        <name evidence="12" type="ORF">D3H35_19920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6 7">An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the polyphosphate kinase 1 (PPK1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="6 7"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03214">
        <property type="protein sequence ID" value="RIE03214"/>
        <property type="gene ID" value="D3H35_19920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009358">
        <property type="term" value="C:polyphosphate kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1840.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00347">
        <property type="entry name" value="Polyphosphate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003414">
        <property type="entry name" value="PP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041108">
        <property type="entry name" value="PP_kinase_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024953">
        <property type="entry name" value="PP_kinase_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036830">
        <property type="entry name" value="PP_kinase_middle_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025200">
        <property type="entry name" value="PPK_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025198">
        <property type="entry name" value="PPK_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036832">
        <property type="entry name" value="PPK_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30218">
        <property type="entry name" value="PTHR30218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02503">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13090">
        <property type="entry name" value="PP_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17941">
        <property type="entry name" value="PP_kinase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13089">
        <property type="entry name" value="PP_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015589">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140356">
        <property type="entry name" value="SSF140356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03705">
        <property type="entry name" value="poly_P_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PP_kinase_N" evidence="9">
        <location>
            <begin position="10"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase" evidence="8">
        <location>
            <begin position="123"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C_1" evidence="11">
        <location>
            <begin position="339"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C" evidence="10">
        <location>
            <begin position="511"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphohistidine intermediate" evidence="6">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="571"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="599"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE03214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="699" mass="79205" checksum="9874F3A5534AA84C" modified="2018-12-05" version="1">MRQSGSFKKYINRDLSWIEFNRRVLEEAEDAATPLLERFQFLAIVSSNLDEFMSVRVAGLNDQRKAGYQKADFTGYSPQSLIKRIIKRTERVTKQQYRVYRDLMRMIAKEGVLLQPWEDLNEEQQDSMKSYFQDIVYPVLTPMAVDVSRPFPLVHSKELYLAVVLRKNDAAETDMSSERTFCAIVQVPSILPRTIPVPGRRNSRKQSFLLLEELIKEQIGLLFSGYETEAVHAFRVTRNSDLTLNEEGAEDLLQEIEKELRRRQRGIPVRLEVEDGIHSHALELLKDELGLEDDVYEIDGPLDLGFLSKFANMLPNLDHLRYPRVEPVYPVEFEEADNMLSVLRERDVLLYHPYESFEVVNDFILEAASDPDVLAIKMTLYRVSTGSVLVQALAKAAESGKQVTVVVEIKARFDEERNIAWARQLEKAGCHVVYGLAGLKTHAKITLVVRREGGSLRRYVHVGTGNYNENTARLYTDAGLFTCHPDIGADASALFNEMTGYSTPHDWRSFAVAPIGLKPKLFDLIDKEIAHAKAGRPARIVAKMNSLSNQSMIDKLYEASRAGVKIELIVRGVCCLCPGVPGLSENIRVVSIVDRFLEHSRILVVGGGGQDQVYISSADWMTRNLTRRIEIMCPVYDTGLSQMLLNLLQMNLHDNVKARELLANGSYVRVSNEHTPLRSQFEAADIPLWKTVAVGLENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWB9</accession>
    <name>A0A398CWB9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04117">
        <property type="protein sequence ID" value="RIE04117"/>
        <property type="gene ID" value="D3H35_09250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="93" mass="10422" checksum="D90D2A1E517171A3" modified="2018-12-05" version="1">MKKLTAGKQQPVFDLPNAVPVELPAPIDASERERKQPNAIVNERTFRMRATMPCRSLRRLPVKARGERLRRLAGGQSLERTQEKGASGENRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWP7</accession>
    <name>A0A398CWP7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="8">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">murE</name>
        <name evidence="13" type="ORF">D3H35_06470</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8 9">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04257">
        <property type="protein sequence ID" value="RIE04257"/>
        <property type="gene ID" value="D3H35_06470"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 8 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 8 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="12">
        <location>
            <begin position="106"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="11">
        <location>
            <begin position="334"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="8">
        <location>
            <begin position="150"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Meso-diaminopimelate binding" evidence="8">
        <location>
            <begin position="409"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif" evidence="8">
        <location>
            <begin position="409"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="108"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="8">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE04257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="495" mass="53899" checksum="6A78BCAF57DD7B76" modified="2018-12-05" version="1">MNLHELSQQLLVYRIEGDGHTVVSRLETDSRKAKQGDLFFCLPGHTVDGHDYAPLAVRSGAAALVVSRQLPLPVPQLVVPDTRHALAALVDYFYGRPSDSLRPIGITGTNGKTTITYLIERILTDAGIPTGVIGTIETRYAGQSFPMSGTTPDVLELQRIFRSMIDAGTSRAVMEVSSHALEQGRVKGTRFRTAIFTNLTQDHLDYHGTMENYEAAKGLFFSRLGNRFEDDPASRAFAVLNADDDASQRFAKLTAAEVVTYGIDKDAHVRAHDVAISSSGTSFTLETVRGTREVNLRLVGKFNVYNALASLAAAWCEGIDLDRAVESLERIPGVPGRVEAVDEGQPFAVVVDYAHTPDGLENVLRAVREIAKGRVIAVFGCGGDRDRTKRPIMGRIASELADVLIVTSDNPRTEEPVAILADIEAGLVQAAVPKDRYTLEPDRRAAIEKAVEMASPRDVVLIAGKGHETYQDIGGVKHDFDDRLVARSAIRSLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX68</accession>
    <name>A0A398CX68_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000035">
        <property type="protein sequence ID" value="RIE03594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03594">
        <property type="protein sequence ID" value="RIE03594"/>
        <property type="gene ID" value="D3H35_10670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="349" mass="38506" checksum="93B6B76ACA6428CC" modified="2018-12-05" version="1">MADWVRSRYGSFAAAPLADGLGYLALNFRTKAREGGRVEWDLSQPMTTWRTIVVSLEPFDTARQAVSSAGLETIVPPPVIVPPLTTGFHQVDISANIPEPGPGVLAVGVTCEPPHPPSRPQAVTASTELSSRSGAAFVRLKLSPLEPLAYTCSTFIVTEDSRGIRQWDGLELARTEERLRLKPDDFPIRFVPIAVSPELLELATIRGRCEWLEANHSSASSAFVLDRDRPELAIAIPAAASNASFDFDVLSVEGDRSFIWDRFSRSRCFLGCIFFPNTDRSRYLSSLPKRLRHLWSRSTFSGKPGRDGRSRYRTGSDAKSVEEELELSGFVAVLSRLPVSEARRSGRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY63</accession>
    <name>A0A398CY63_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">INTEIN_C_TER domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03934">
        <property type="protein sequence ID" value="RIE03934"/>
        <property type="gene ID" value="D3H35_08190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029501">
        <property type="entry name" value="EndoU_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14436">
        <property type="entry name" value="EndoU_bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTEIN_C_TER" evidence="1">
        <location>
            <begin position="847"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="970" mass="108876" checksum="76D4D5581C8395D8" modified="2018-12-05" version="1">MGELAETVDAYGNLNRSEYDFTTRKRSNYFVPAANVASFRQAPSASLKENMLESILDQWGNIVQTSVYPNWTSTTGALNQYYTYDFSGNVTSNTDAKGNMTSFAYDKLDRLVSVTDPLQQISEYKYNLLGELSAIKQGNTWTTSRTFDEAGRLITKTSASGQSEQFAPDKSGNLTAKSDLNQSVFSYQYDSNNRLKNEQVGNQEIRTFYSTPFGAGSVKWYENNGLKQFQTISYTNYGLLSSSTIISEGYIHKFTNSYDKLARTTRVEDSFDRYTRYYFDKSRIKRVQTDGSSAQYTTDSQYAEYDFYPDGKLKSVTYPKLSDGTYLKTEYVYNKLNRLTSVTNKKGSQSLSFFNYEYDNNGNMTSVTDSTGTTTYGYDALNRLTTVLRPNGDNDAYTYDVFGNRTISKQSTSGEQPAWTDSTYNFDKWNRLTSVQSGATTTNIQYGLDGLRIKKTTGSDATRYHYNAAGEVIAESNAANTVKAQYVRGPDRILAKLDKTTQTEKRYYYLYNGHGDVVQIVDTAGVVKNSYKYDEWGNIDTQSETVDNMFKYAGEMYDKETGLYYLRARYYDPSIGRFISKDSYEGDLANPLTLNLYTYVYNNPMMYLDPSGNIGWRQIDNLLMGIAASAGDTLMDMLKSPWTLMQLGKALITGDLSFVDLGKAIGASAIEPIRYLVENSKHVWGGKPTNAEVKEYGKQLGNVLQMALGSSAAMKIIAKAVPRLAKGLKAVEAASCNCFTAGTKVQTDEGEKKIEDIEVGDRVLSKDETTGEVAYKEVTATFNHETDEIYNIYVGGQTIESTFNHPFYVKDKGWTFVKDLKVGDLLVQSDGDTLKIDSIELEYKNVTVYNMTVDEFHTYFVSDLGIWVHNTACKPINLPSYKKVEIDMEHISSGHIANGSRAQQSGGKTIFPSYMNEAQVEKTVRAAYKNGSRLQTQGDRVLVRGEANGITVEMWVNTKTKTIETAYPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZP3</accession>
    <name>A0A398CZP3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pknB</name>
        <name evidence="11" type="ORF">D3H35_07360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04394">
        <property type="protein sequence ID" value="RIE04394"/>
        <property type="gene ID" value="D3H35_07360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="10"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="362"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="430"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="501"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="654"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE04394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="687" mass="75946" checksum="B06DB29EEA5014B9" modified="2018-12-05" version="1">MIGHTLVGRYELLARVGGGGMALVYKAKDILLNRFVAVKVLRQQFMHDEDFVKRFRREAQAAASLSHPNIVSIYDVGQEEDTHYIVMEYIDGANLNEIIRDRAPLQVEEAVRIASQICDALDHAHHNQIIHRDIKPHNILIGNNGRVKVTDFGIARAVTSSTITQTGSVVGSVHYFSPEHAKGVATGEKSDIYSLGIVLYQMLTGRLPFLGESPISVALKHLQEPFEQPRKVNPHIPQSVENVILRAMRKNPQERYSSASRMLADLETCLQPQRINEPAVQFDSDDEEEEKTRVIPAIRSDMRSSLDSQTIVSGNSQNQWNSDGLEEERKKRWVLPTVLGVLAALLIAVLVWAVFALKEQLTPADVVPPTVIGSTETEARAALEAKGFVIQEPTIYQANKDVAKDLVIDQSKKDIPIKEGSSIQLTVSTGPDLPVIPKLTGKTYEDAVEELKLLGIAEDSIHKKEAYDSSEPGTVLEQSIEPDATFDQEKGDEITLTVSKGKEEFAMPNLINKSESEARAEIQKNDLKLPDKNVFREPSYAAPKGKVFKQFPAEQNETVSAGTEVSIWISTGYPPEAKEKSWEVTVPPAEEGKESTIRILYSDARGDNIEWGTPRKIKAVTTFPIKLILSPDKSGQITVYRNNEYLDRIPVPYNDVPAASTIEPPSPAPNDGGGESESPVVEDQGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZR9</accession>
    <name>A0A398CZR9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_00785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05357">
        <property type="protein sequence ID" value="RIE05357"/>
        <property type="gene ID" value="D3H35_00785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="106"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="304"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="499" mass="54710" checksum="DB5510EF83873CDF" modified="2018-12-05" version="1">MVQAVRGGRARRRFFVPRVHGRGVSKLARQRLRSIRICLMRCASHEFRFLFLCELLAADRMDPGRIFRRSAGRPGSRMGYAEREGVETYRMKIVIMNSLYTPHIIGGAEISTQILAEALVSAADVHVITLGGQKRTDGVLEEKIGGVTVHRLPHNNLYWIGEAKRRRGVLAKTARRLVDLYNPWQIGAVKERLEAIRPDLIHTQNLSGFGAAVWTAAASLGVPIVHTLRDYSLLSPVSSPISNPALSRLYALTSGGFSSRVAAVVGISSHILKRHTDAGLFRGAARHVIPNAVVGKIAASGGKEFDRKPLRIGYFGRIEPEKGVPELIEAVLSLPEAVVEQAIICGEGSLRAKLADSCRHDGRIFFTGQVKPAEARSMMAQADVNFVPSVWEEPFGRVIIESYQVGTPVYASEVGGIPDAVWNPDEFLFPPGSVAAIRNKIVAFHALSGDEKRRIQASCLEHCGKFTQTSLLEKHLDLYARTLISGSDYAAEAAYGQVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZT9</accession>
    <name>A0A398CZT9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04434">
        <property type="protein sequence ID" value="RIE04434"/>
        <property type="gene ID" value="D3H35_07570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="372" mass="40249" checksum="7F705326EB614DDA" modified="2018-12-05" version="1">MINLTNEQKELFAYIDGILPGDGHLKYDFRDEKQYEFAVMMSQLSGDADLYPGKLKSLELMKAYQEQHGLQENEPQTADGWTNMFKIPGLNLTTDGTIASNGLATVVGGYASMNLALIVQSRKTKDIVAHGFNNDFAKALLTVSTAASTSKEIDVNSYLHYQYTTSSGSETASPQSGLVKKQDNGGTTGDPVITAPARTTTKPNNPKAINIGLGRPWTDQGGDSQFDYAWYESTQDHPIGKIPFVGSATFSQAISTPLEPNTNFLLDIYVADEVGGGGAQLNPTDLDTVYKAFSIDSGNDAKLNWSLPAGASTTDPGNPIVFGNVTWSSDILAISIVKSPLFYPGDGSLAFATSKLRFSDSDRWMERIYEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZV0</accession>
    <name>A0A398CZV0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04444">
        <property type="protein sequence ID" value="RIE04444"/>
        <property type="gene ID" value="D3H35_07620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="73" mass="8114" checksum="BE269E6D86447D8C" modified="2018-12-05" version="1">MMDRKTIFSNWLPRRARPEKKPRDVCVGKARSELARNGGLLISKILGGIEDGVRFGELNGEGTDRTGGRGTWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D047</accession>
    <name>A0A398D047_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04841">
        <property type="protein sequence ID" value="RIE04841"/>
        <property type="gene ID" value="D3H35_05080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017334926" evidence="1">
        <location>
            <begin position="36"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="157" mass="16786" checksum="B5FA702E3834F7ED" modified="2018-12-05" version="1">MKKGMHQRASVSAMLLLIAALLVGCSSEDGNKAETASKAGESAAKADPFADAPSVEVADLQSGLALLNDMVKSFKQSVESDDAGSLTELTGQMSGVWVKIGTEVKSGNPQLFESVNDLLAKLAEQARSDKPDRDALIEQSYSLYQQIRDARKQLQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0G7</accession>
    <name>A0A398D0G7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_02195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE04981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04981">
        <property type="protein sequence ID" value="RIE04981"/>
        <property type="gene ID" value="D3H35_02195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="297" mass="32912" checksum="1EADEE4D74A3E4CA" modified="2018-12-05" version="1">MQKLLISLKEAFKRVSGKSILSEISFAVREGETTAILGPNGSGKSSLLKLLSGLSSLSSGVRTVVHPTDRNLVIGYAPDRFPKLRFTAREYLMSMGMIRGIPRNVLESRIEQLLRLFQLEEAADRETIHYSKGMLQKTNIMQAILQVPDVLLLDEPLSGLDADMRKQLMGVLFDLKAQGVSIVLTSHEKAFVELLADRIVTLRDGNIITDDLIIQDSVSRPQKRIKRIEFRLPADIANEWNELADMEGFISWEQLGSSYYAAAVLAVCSTPILKAILDAGGTVESVSDLVLKSERAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0M1</accession>
    <name>A0A398D0M1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_02580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05041">
        <property type="protein sequence ID" value="RIE05041"/>
        <property type="gene ID" value="D3H35_02580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="15"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="100" mass="11346" checksum="D186B351665FA923" modified="2018-12-05" version="1">MRYYIVFLQTIDAAGASQYQQAHFEYQSSLRLQGVIFAHGRLTDGWGGVAVYRAGSEADVRLYVEEDPFVRNGIRSYEIHEWDMKLAPDVSVGAREEGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CAU8</accession>
    <name>A0A398CAU8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_30010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00266">
        <property type="protein sequence ID" value="RIE00266"/>
        <property type="gene ID" value="D3H35_30010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="199" mass="23599" checksum="DAF2F679533840DE" modified="2018-12-05" version="1">MQTLMSGMRYLSLGDRRAEMLMSGMRYLSLGEWRAETLMSGMRYRSFGDRRVQTLMSGRRYLSLGDRRVQTLMSGMRYLSLGDRRVQTLMSGMRYRSFGDRRVQTLMSGMRYHSLGEWRAEMLMSGRRYRSFGDRRVQTLMSGRRYRSFGNWRVQTLMSGRRYLSLHAPRPGKKRLPARRRHDKRRTPGARRSLIVTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBQ8</accession>
    <name>A0A398CBQ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_29690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00210">
        <property type="protein sequence ID" value="RIE00210"/>
        <property type="gene ID" value="D3H35_29690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="4">
        <location>
            <begin position="21"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="5">
        <location>
            <begin position="107"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="305" mass="34048" checksum="9CB7CEE7C6CEFB5C" modified="2018-12-05" version="1">MGSSKPLCLIDKSIVLSIVEEEQLEQCFTVKYVDQAASDAALFERCDAFLIHSYFPHSILSTLYQCKYIGIRAHNLDYVPTDVLPDPSIVIENIPPVAQNSVAEHVFAMVFFLAKQLGKAQHNVASGRWRKDLQPSMELYGRNLGIIGYGEIGQAVANMGRMLGMNILIANKPGRELTEGYPLEQVLSQADVISLHLPARQENNAFINRERIQGMKRGTILINTARGSILDYDALEDALKSGQLGGLGLDVFPTEPVRHPVDHFMTLSNVICTPHTAYYTDRTMTQMNRHLIGKAIRFFSETLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCN8</accession>
    <name>A0A398CCN8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3 5">4.6.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">moaC</name>
        <name evidence="7" type="ORF">D3H35_25745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoaC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00966">
        <property type="protein sequence ID" value="RIE00966"/>
        <property type="gene ID" value="D3H35_25745"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_B">
        <property type="entry name" value="MoaC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaC" evidence="6">
        <location>
            <begin position="19"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="79"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="116"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="167" mass="17494" checksum="839AA820056AEF6E" modified="2018-12-05" version="1">MRDAHDGLTHFNEQGRAVMVDVSDKPVSARTAKAEGKVVMAPDTLRRIREGAVAKGDVLAVAQVAGIQAAKKTSDWIPMCHPLPLTGVNITFGDNGKDTLFITAEVKTTGKTGVEMEALTAVSAAALTVYDMCKALQKDMVIGPVQLLLKTGGKNGDYEAASEAGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD17</accession>
    <name>A0A398CD17_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000051">
        <property type="protein sequence ID" value="RIE00603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00603">
        <property type="protein sequence ID" value="RIE00603"/>
        <property type="gene ID" value="D3H35_27475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="73" mass="7959" checksum="90BFB200AE3CF8F6" modified="2018-12-05" version="1">MHWTVPSSKGTTARLGLSFAIERSLDNIRRSSAGSSRRFTSNMRNPPPFAPPVTAAGLYLMKVNAARPSRRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD33</accession>
    <name>A0A398CD33_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_29235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000058">
        <property type="protein sequence ID" value="RIE00325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00325">
        <property type="protein sequence ID" value="RIE00325"/>
        <property type="gene ID" value="D3H35_29235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="154" mass="16897" checksum="095FF2B38C9E41EB" modified="2018-12-05" version="1">MAAVTEHLGFAVTSSITYDHPYAMARKMSTLDHLTGGRIGWNIVTSNLNSAALNFGWREQLEHDRRYDRATNFLRCATSYGNEAGRTMRSFGIGSGASTPTRPKFTISDTRASSSRCRAFICPSHRPSGRRCSSRPAPRSGEGCSPQSTRNASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD56</accession>
    <name>A0A398CD56_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_22120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01116">
        <property type="protein sequence ID" value="RIE01116"/>
        <property type="gene ID" value="D3H35_22120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="301" mass="32019" checksum="7534A0418082A630" modified="2018-12-05" version="1">MRDSATTATAKAVLRRGKWELPALRVPGRRLNFPKLFVGLAAIVIAFIALCAIAPQWVAPYSPTEMMTDILLQSPSAAHPFGTDYFGRDVFSVVVYGARDSLFIGLLSVLVGGLIGGTIGALSGYIGGWFDTTVMRGIDVLMTIPGILLALAIAAALGPSMTNIVLAVAAASIPGYARVMRSQTMSINGRPFITAARSIGVSNFGIFWRHVLPNSLSPLLVMTTIGIGTSILAGSGLSFLGLGLLREIPDWGTLLSQGRGYLTIAWWICTFPGLAITMLVLSVNIVGDWLRDNLDPKKKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD73</accession>
    <name>A0A398CD73_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00660">
        <property type="protein sequence ID" value="RIE00660"/>
        <property type="gene ID" value="D3H35_27240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="121" mass="14014" checksum="44F018B9243C9BD5" modified="2018-12-05" version="1">MATNYLQNIDEAFLRRINYVIRFSIPDEEQRKAIWQGIFPAETPLDRELDYDFLARKLPVAGGNIKNMAITAAFLASDSSEAVGMKHILKAYQYELDKTNRAMTKDELAEYAFYFDEIHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDR8</accession>
    <name>A0A398CDR8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="10">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glycogen branching enzyme</fullName>
            <shortName evidence="10">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">glgB</name>
        <name evidence="13" type="ORF">D3H35_26680</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="10"/>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00780">
        <property type="protein sequence ID" value="RIE00780"/>
        <property type="gene ID" value="D3H35_26680"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="6 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="12">
        <location>
            <begin position="154"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10 11">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 11">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE00780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="632" mass="72529" checksum="C64DFDA05118C21C" modified="2018-12-05" version="1">MQSQDALLSKDELYLFNVGQLFQAYRTLGAHPIELDGQKGVRFAVWAPHAQSVGVTGDFNGWSEVGHSLVRFGTTGVWTGFIAEADVGSRYKYAIVDSSGANRLKADPFALQSELRPNTASIVNRIDGYEWHDRDWMERKKRNPPYDGPMLIYEVHLASWRMDAPEHFRTYEQLSIELVEYAQTMGYTHIELLPIMEHPLDRSWGYQTTGYYSATSRYGPPDGLKVLIDKCHQGGIGVLLDWVPGHFCKDDHGLRLFDGTALYEDEDYRRAEKPLWGTLAFDFGKPEVQSFLISDAVFWLDIYHFDGLRVDAIASMIDLHFDKPDELKTNNKYGTSEHLEALDFLRKLNETVFRHFPEALMIAEDSSSYPAVTSPTYLGGLGFNYKWNMGWMNDMLRYMETHPDQRSSHHSLITFSLMYAFSENYVLPLSHDEVVHGKRSMLHKMPGSYEEKFANLRLFYGYWMTHPGKKLLFMGGEFGQYDEWKDFAGLDWELLQYPLHDSMHRYVRHLNRVYLDTPSLWELDHNPEGFQWIDVNNAAQCILSFLRIGKKEQSFALSVCNFSNQSYPRYRIGVPSPGRYRHLLNSDEADYGGSGISIPKEVSAESVPMHGQPCSIDVPVPALSFGLWEKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE81</accession>
    <name>A0A398CE81_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_25605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00940">
        <property type="protein sequence ID" value="RIE00940"/>
        <property type="gene ID" value="D3H35_25605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041474">
        <property type="entry name" value="NicS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17938">
        <property type="entry name" value="TetR_C_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="197" mass="22917" checksum="41975FB732E97575" modified="2018-12-05" version="1">MQPAEQDVKMRLLQAAKKLFARQGFDGTTIRQICEEAGANVALISYYFGGKDKIFQALLETFFTQTVMDDILSGEPSPVEGIRKVVKEVILFQLREPELVRLFQMEIMMFSPRIELLRQGKFPLWHKLLHLLEQGREQGTFTFRSIDHTFSFIMSLLFDRDSTYFSPLMREEEQTPEQLIEDMTAFILNGLMYKADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEP5</accession>
    <name>A0A398CEP5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_29120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000057">
        <property type="protein sequence ID" value="RIE00332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00332">
        <property type="protein sequence ID" value="RIE00332"/>
        <property type="gene ID" value="D3H35_29120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="69"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="294" mass="33538" checksum="4C340C35F75153D3" modified="2018-12-05" version="1">MEKYLSRKSYITVFLLPALVVYVFTVLLPIGWSAVYSFYEWDGISPMKFTGFDNYIRMFTEDDVFWQVFKNNIVFTIVNVVFQVSVGLFIAVLLTKIKRGREIFQTLYFAPVVLSTVALVQIFQNVFSVNPVGMLNYFLSWFQPSMLDSEWLSDPHRSLLIVAIAEGYKFAAVYMVIFYSALISISEEVIEAARMDGASGWKLYRYIKLPMIKGIIFTSIILVLNGSLKSFDIPYLLTYGGPGTSSELVATYMYKQAFSSMYYGYGSAIAVFIAVECFLLVGLVMQIFQMKKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF71</accession>
    <name>A0A398CF71_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage V sporulation protein T</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spoVT</name>
        <name evidence="3" type="ORF">D3H35_23675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01373">
        <property type="protein sequence ID" value="RIE01373"/>
        <property type="gene ID" value="D3H35_23675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014213">
        <property type="entry name" value="SpoVT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026579">
        <property type="entry name" value="Spore_V_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02851">
        <property type="entry name" value="spore_V_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="180" mass="19597" checksum="9792E5FB2CAE9454" modified="2018-12-05" version="1">MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEVILKKYSPIGELGDFAKEYAESLFESTGHIAIITDRDTVIAVAGASKKEFLEKSVGNLLENIMENRKIALEPGPGSYEILKDIAETYSSVAVAPIVAGGDPIGTVVLLSKEEGVSMGDMESKMVETAAGFLAKQMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFG2</accession>
    <name>A0A398CFG2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2306 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01155">
        <property type="protein sequence ID" value="RIE01155"/>
        <property type="gene ID" value="D3H35_22375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018750">
        <property type="entry name" value="DUF2306_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10067">
        <property type="entry name" value="DUF2306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="217" mass="25057" checksum="C2032761A7F4E7A3" modified="2018-12-05" version="1">MLRAIRTNKWLSIVAFLAIFLSLYLGVQYFVMGADQSGLVQDKLGEMNLNDLWYVMVYTHVATAIAAICTGWLQFISKLRSRSYRLHKAIGRIYSVGVLLGGISGFYLSFYATGGWVSSVGFLLLSILWLYTLVRGIRAIAVKKDRAEHQRWMTRNYALTFAAVTLRLYLPICMAVFGLEHFNDYYRVIAWLCWVPNLFFAQWLLTRRKRKPIAVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFH3</accession>
    <name>A0A398CFH3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Copper amine oxidase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_24270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01473">
        <property type="protein sequence ID" value="RIE01473"/>
        <property type="gene ID" value="D3H35_24270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017378795" evidence="2">
        <location>
            <begin position="27"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="3">
        <location>
            <begin position="66"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="277" mass="29931" checksum="BE2D787BFB6334B9" modified="2018-12-05" version="1">MQIKKSVFAASLVACSLVFGAIGVGASTGIEQIKAALNHNIKFKLDGASWTPKDSKGKALSALVYNGSNYVPLRAVAEALGADVGYDSKTQIVTINSADNSGVPYDDVKENTSSNTDETKAPSDNGLIYLSGTTATMTTKMKEQAVTVIKLYADALATGSMAKFNAYYDSYVSDKRANSPISLGHDYYKEKFKKDVEATIKGNDASDIADYAKTLKNVTLADIEVSYVGEKSEYSQSFQYSYYPKGWSAFSGVFVYFSFNAIEYDSDTFVLADVHIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFJ8</accession>
    <name>A0A398CFJ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_27310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00672">
        <property type="protein sequence ID" value="RIE00672"/>
        <property type="gene ID" value="D3H35_27310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="218" mass="24637" checksum="7A0410392F755B0D" modified="2018-12-05" version="1">MPKLGMEPKRRADVINATLTCISVHGIDGMTLDKVAEYANCSKGVVTYYYKNKDNLTIEAFKSFLAYYGLKIDSEIENTMTAGNMIDVTLKHILPPYRDDTEKRVNVSQLDGIEKMFIPHEDQAKLFLQFFSKAVLDRNLQEVVSKSYLADLQGIAKIFDYGNRTGQMSVEDSQSAAYGLLAMVVGLSFFRVANIPPINGEDNRYICEDYVSRFLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFR0</accession>
    <name>A0A398CFR0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsH</name>
        <name evidence="9" type="ORF">D3H35_23485</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01340">
        <property type="protein sequence ID" value="RIE01340"/>
        <property type="gene ID" value="D3H35_23485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="199"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="610"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="645"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="207"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="670" mass="73961" checksum="73AD1ECC41B55DCD" modified="2018-12-05" version="1">MNRIIRNTGFYLLIFLVTVGIVQFFISKNETTEELSYSQLVKVVEQGNVSELTLQIQGGSYLVTGKYKEKPSNIKSETFVGRAPLAEYVPQNFEALSKSKGFDFKNKKMPGESFWLTFLTSIIPFIIMFILFFFLINQAQGGGGKVMNFGKSKARLYNEEKKRITFEDVAGADEEKQELVEVVEFLKDPRKFAALGARIPKGVLLVGPPGTGKTLLARAVAGEAGVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNSPCIIFIDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGFGANEGIIIVAATNRPDILDPALLRPGRFDRQITVDRPDVKGREAVLKVHARNKPLNKDVRLGTIAKRTTGFTGADLENLLNEAALLAARKNKKDIAMQEVDEAIDRVIVGTEKKSRVISDREKRIVAYHEAGHTILGFFLEHADMVHKVTIIPRGRAGGYVIMLPKEDRMLVTKQELLDKITGLLGGRVAEELFIGEIGTGAYSDFKQATGIARSMIMEYGMSEKLGPMQFGSSQGQVFLGRDIGHEQNYSDAIAYEIDQEMQRIIQDCYDRAKKLLTEKSDAVHKIAQTLLSVETLELEQIKRLIETGTLEGGEDNGEGSADSSVEESKAEPIVDTLGSGVRVRIQTRDDELTPPAPDNRNDDGTEDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFZ9</accession>
    <name>A0A398CFZ9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable cell division protein WhiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">whiA</name>
        <name evidence="8" type="ORF">D3H35_21410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cell division and chromosome segregation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WhiA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01643">
        <property type="protein sequence ID" value="RIE01643"/>
        <property type="gene ID" value="D3H35_21410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043937">
        <property type="term" value="P:regulation of sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01420">
        <property type="entry name" value="HTH_type_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018478">
        <property type="entry name" value="Sporu_reg_WhiA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003802">
        <property type="entry name" value="Sporulation_regulator_WhiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023054">
        <property type="entry name" value="Sporulation_regulator_WhiA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039518">
        <property type="entry name" value="WhiA_LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37307">
        <property type="entry name" value="PTHR37307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02650">
        <property type="entry name" value="HTH_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14527">
        <property type="entry name" value="LAGLIDADG_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10298">
        <property type="entry name" value="WhiA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00647">
        <property type="entry name" value="DNA_bind_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WhiA_N" evidence="6">
        <location>
            <begin position="19"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="LAGLIDADG_WhiA" evidence="7">
        <location>
            <begin position="127"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_WhiA" evidence="5">
        <location>
            <begin position="222"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="313" mass="35530" checksum="33281C3A01FA0D5C" modified="2018-12-05" version="1">MSFAAQTKKELTLVEAEACCEKAELSALIRMNGSVSLTNRRIVLDIATENAAIARRMYTLLKRHYSIPTELLVRKKMRLKKNNVYVVRIPAGVEELLKELGIITATEGFQFHPSIDKNIVRKTCCKKAYLRGAFLAGGSVNNPEGSSYHLEIASMYEEHCQALVELANRFQLNARFIERKKGFILYIKEGEKIIEFLSLIGAHQALFKFEDVRIMRDMRNSVNRIVNCETANLNKTIGAAVRQIENIKLLQKEVGLESLPEKLREVAEIRLQYPDINLKEVGDMLKGQVSKSGVNHRLRKLDEWAEKIRNGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG69</accession>
    <name>A0A398CG69_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02216">
        <property type="protein sequence ID" value="RIE02216"/>
        <property type="gene ID" value="D3H35_15880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="369" mass="41664" checksum="971951E1EE0849A5" modified="2018-12-05" version="1">MAEPLKEMYRETFLREFAAKVRAVYPVFDTDGFVEATLGDGWDELELKGRIRRITESLGGKLPLEYGKALDVLEAIADNCRGFPYLFFPDFVERYGLEHWERSVDALAAFTPMSSSEFAVRPFIRRDEGRMLATMMEWASHPDEHVRRLASEGCRPRLPWADALPAFKRDPSPILPILERLRADSSEYVRRSVANNLNDISKDHPELVAKLAERWLGSDAATDWIVRHACRGLIRAAHPAVMALFGMRPQPGVRVEEWTVSPDSVPVGGSVDVRYALAMPPGEPIKLRLELAVYYPRANGRLYRKLFKLSEKVVLGGSRAYGSRRHSFADLSTRRHYPGVHKVALLLNGEQAAEAVVELLPPENGGERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGP7</accession>
    <name>A0A398CGP7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_21820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01650">
        <property type="protein sequence ID" value="RIE01650"/>
        <property type="gene ID" value="D3H35_21820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017316210" evidence="2">
        <location>
            <begin position="32"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="77"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="334" mass="35579" checksum="19A6145DB1284B48" modified="2018-12-05" version="1">MNVRRAGKLIVLCTVLCAGLLAACSSDNDSAGPPAATAPASSEAPSAVESSAQASAAVYPQSFQDELGHEVKLPAAPVRIFAPGLEDSLLVLGVTPVAQWANGNVVPAYLQERMASVPKADFAAGLPTPETVMSYAPDLIVLNNSYYAENGVYEKYAKIAPTYVFSNAATDIETSLRKLGELFGKSAEAETALEDYRSKVDQAKTKLAAAADGKKAVIIRFNARGMFLLGGDYYGGYVLAHDLGFGKIKLVEHESSADLSLEILPELDADYIFLVNDSQTGNAFLKELTESALWKGMKQVKNGNVYEVQDESWLYGGLIASGNVIDETVRLLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGW6</accession>
    <name>A0A398CGW6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_29175</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000058">
        <property type="protein sequence ID" value="RIE00319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00319">
        <property type="protein sequence ID" value="RIE00319"/>
        <property type="gene ID" value="D3H35_29175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="138"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE00319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="297" mass="32289" checksum="7E8AAD81C91202A9" modified="2018-12-05" version="1">MKMNFGKIASPIASRLLVIAGFVFFSIAFVCAFVHSLTVFDSFSSASGAFLAAVIALLAVSALAMNRRVGKKAFIIIVPGVALALRLIWALLVDTPPSSDFLFMHNAALAAAKGDFSFASSDYYTSWAYQLGFTMYEALIVKLFGTPIIFLKVINVLWSTGTVALVYWTAGKAFNEFCGRAAAIAYAFYIPNIVMCSVLTNQHVSMFFFMLGCALLVHRGLTGKYSWLLIGLSFAIGHIMRPIGGVYIAALLVFVTVFRAFPWSLKRSGPLLAKTAGIVVVFYLLQATVSQSFIQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHI3</accession>
    <name>A0A398CHI3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02223">
        <property type="protein sequence ID" value="RIE02223"/>
        <property type="gene ID" value="D3H35_15925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="187" mass="20733" checksum="6551FB81D0340538" modified="2018-12-05" version="1">MKKLILFLVALLLLAVLAGAGLILYIAPDKGLNLAYEQVPVKDRAIEMVKRMKLELVLSEEDVINLAKASVADNPQVKPDVRVTGADFDLQGELLIANLKVLWKERIPVGLQVTYRLSWQSPNLVATVVEAKAKKIKLPLTAFDDQIIPLGDELPKLIQIKGIAFENDEAKVSFKKPSLKDLRSLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHK8</accession>
    <name>A0A398CHK8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_18800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02706">
        <property type="protein sequence ID" value="RIE02706"/>
        <property type="gene ID" value="D3H35_18800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="118" mass="13123" checksum="FCD16B44480AB73A" modified="2018-12-05" version="1">MRSRFRQGAFRHAGVGKTSDSSIIGHGVGRQRQIGSAAIFPTASFFLSGIRKNRRAGGPSVRRISGRSRRWGVHGVLFRYDRSEQRSVEEPVAESTVRGPRDGFTEAWASICRSFARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHS8</accession>
    <name>A0A398CHS8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TVP38/TMEM64 family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_13975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01885">
        <property type="protein sequence ID" value="RIE01885"/>
        <property type="gene ID" value="D3H35_13975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="PTHR12677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="208" mass="23316" checksum="16DCA723F84A4A54" modified="2018-12-05" version="1">MSIADTLSSLTEEDLKSVLEQYRSLGPLPGIFLTFLKSFVPPLPTIVIVGVNAATYGLWLGFLYSWIGMVAGCVTTFLIVRRIGRSRFVERWAQKPRVQKSMIWIRRNSFGYVFVLSLFPVGPFVVINMAAAIARMPLRSFVIAILFGKAVMVFSVSVIGHDVMRFFRHPAELLYVAAFVAISYVVSKKLETRFTKEPEDGKDSGQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHT0</accession>
    <name>A0A398CHT0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02806">
        <property type="protein sequence ID" value="RIE02806"/>
        <property type="gene ID" value="D3H35_19420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="102" mass="11855" checksum="92E4CC1758F7B9AA" modified="2018-12-05" version="1">MDYSKMCPKYESAADLLGKKWTGLIIRVLLGGPKRFKDIKGQIPDMSDKMLTDRMKELESLGILTRTVYPEMPVRIEYELTEKGRGLEEVIQSIQNWGEEWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI00</accession>
    <name>A0A398CI00_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01965">
        <property type="protein sequence ID" value="RIE01965"/>
        <property type="gene ID" value="D3H35_14435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="68" mass="6529" checksum="791E88DB133229EC" modified="2018-12-05" version="1">MDSASAGSDAGGAVSTVSDGAGEADVPPTVAVSTGVADAGSVIWLASSSRAHAASGQSKREKGRGKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI19</accession>
    <name>A0A398CI19_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4247 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_14550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01985">
        <property type="protein sequence ID" value="RIE01985"/>
        <property type="gene ID" value="D3H35_14550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025341">
        <property type="entry name" value="DUF4247"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14042">
        <property type="entry name" value="DUF4247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017325154" evidence="2">
        <location>
            <begin position="34"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="259" mass="27734" checksum="D68DA4E0596E607B" modified="2018-12-05" version="1">MSSRLSRWASAIHLSVVLALMVTLLSACGSLKVEETYPLESVNGSGSQTSYVYRAAGVTVQEAAKELVEQKKPEQQSKADPDHMFLVYSDQVIHVQKDENKPEDSLVEVDSKEYFRQNYSPSFLEGYLLANLIGSLFDGGPRSGGYGDYRGYGSMGSNPPATGKYHAPSAAEKKAAPPVTVEKKGSIFKRSKTGDDGSSVGSNGLFGKKSSSSSSSSSGKITREDGSGSSKKSSGYFTPRKKSAPRTKSGGFGRISKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI60</accession>
    <name>A0A398CI60_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD-GYP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00518">
        <property type="protein sequence ID" value="RIE00518"/>
        <property type="gene ID" value="D3H35_27620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="1">
        <location>
            <begin position="156"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="394" mass="44200" checksum="E7B9AD479437E162" modified="2018-12-05" version="1">MRRHFSCQSATGCKRSAGNRLVRNLSAPGAILVAIHPIPCFTTNRRAVPSMNPEPSSREASALKWVGKRLGRDLFKPNGVLILNASHRLSPDDLSRLAEHGIVLSEQDIEKPKHESEILRALEQSVSQMEDIFKNIRLKGQIPLLEIRNEVLPAIYESTENVRVFPLLLSLQAKDEYTYRHNVAVGAISSMLGRWLGLPENELAVLTVGALLHDVGKMRVPESILNKKGKLTDEEYDIMKKHTIYGYEMLQSCVGLSRRSALIALQHHERDDGTGYPLRIASDKIDYLSKIVSVADVFHALSSNRVYRAASPFYEILHRMYTGTLGPFDRAILRTFTRRLMNALVGSEVELTDGRVGKVVLINPVDPTRPLIQIGRQFLDLSREPGIRMEQIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIF9</accession>
    <name>A0A398CIF9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_27055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00628">
        <property type="protein sequence ID" value="RIE00628"/>
        <property type="gene ID" value="D3H35_27055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025883">
        <property type="entry name" value="Cadherin-like_b_sandwich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12733">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017268998" evidence="2">
        <location>
            <begin position="26"/>
            <end position="2863"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="3">
        <location>
            <begin position="70"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin-like" evidence="4">
        <location>
            <begin position="427"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin-like" evidence="4">
        <location>
            <begin position="2046"/>
            <end position="2135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="2863" mass="305522" checksum="C649050EAE67FED8" modified="2018-12-05" version="1">MKIRKLLMLSLASLLLALPVLGLFADDTFAATSRVAIIKELKGTVQVKKSGGSKQFKAFAKMSLNEGDILSTGSGGSAVLQFANGTSEDDKMTVSANTTLTFSKLSDRKGTRTKVSMLSGSAWVDVKSISSKNDEFTLETPTAIMGVRGTHLYTYVDPVTGNSRLAVGAGVVRVSTPDNSSEYRDIVPTQDVLATQDDDGNGKITIAPIDLQRLLSQSDSAVVDAILQSAAEIAKENEQLMQKYLEEINSGSATEEERHKRNIENLLGAIVDQALTSGLISKERVDKLISDAQQGSGVTIDLSKKELDFSEQEKREQELFRQKQAQALAEAEKKKQQELAELQKKMQDELKKLQEQRKAAEEANKKAEEAKRKQAEELYKKQLDEAAKKKFEEEQAKNEGNTGSTSSGSGSSGGSSQAPKSQNADLSGLSLSNGANISFAASTTNYEANVLKNVVSVSVTPTTAHSKATIKVNGTNVTSGASAAIALGASGTTKSIDVVVTAEDGTTTRTYHISVYRSLISAVTLPTNLGIQFDPAKSSYYIPAVSETTASIPMTFGSLTDSVKVQLWVWENGGYVLKEEYMPGQSFNVTLNPGNNDIEIRIVPYGSLGGAAYTQVASLSLNSLLGVVETAPVGSSQTYKFQVWKKSGTESGLLYGIDLWKGAASYPVAKTVGSATEWNTTVPGELFAAEAKFFPAEPTDIIVVNNVSYKYGQSVPLSFPNSTTVAFVLKSQSGETKGTFSLVVNKTPILSGENAITAFSLPGQIGTSVIDSAEHTVAVKLPHGSSLIDLQASFTLSVGATAKVNDLLQASGSTANNFSSSVTYVVTAANGNVQNWTVTVTVAPSGENAITAFSLPGQIGTSVIDSAEHTVAVKLPHGSSLIDLQASFTLSVGAKAKVNDLLQASGSTANNFSSSVTYVVTAANGNVQNWTVTVTVAPSGENAITAFSLPGQIGTSVIDSAEHTVAVKLPHGSSLIDLQASFTLSVGAKAKVNDLLQASGSTANNFSSSVTYVVTAANGNVQNWTVTVTVAPSGENAIMAFSLPEQTGPAVIDPVAHTVAIQVAHGTNVTNLKATFALSSEATAKVGSTTQVSGTTLNSFTSPVTYQVIAANGNEQNWTVTVTVAPSGENAITAFSLTEQTGPAVIDPVAHTVAIQVAHGTNVTSLKATFALSSEATAKVGSTTQVSGTTLNSFTSPVTYKVIAANGSEQNWTVTVTVAPSGENAITAFSLTEQTGPADIDPVAHTVAIQVAHGTNVTNLKATFALSSGATAKVGGTLQESGLTLNSFTSPVTYKVIAANGSEQNWTVTVTVAPSGENAITAFSLSEQTGPAVIDPVAHTVAIQVAHGTNVTSLKATFALSSEATAKVGSTTQVSGTTLNSFTSPVTYKVTAANGSEQNWTVTVTVAPSGENAITAFSLSEQTGPAVIDPIAHTVTIQVAQGTSLIGLIPTFTLSTGATAKVGGTLQESGLTSNNFTNSVTYTVTAENETVQNWVVTVTSQLSDGITQFTLENAQGILPLKWLYSSSEWEDIITTEYSTVVNETDTSVQLEVAFSGAVTSASVSNSNGEEIHDYDNSEGPISFNLEQLLDQESPYTELYIEYSYDGLSYEVKLTVLRGDAPEEELSIYDPGMNYSEFTLLPTNRTGDRDFVGYVPTETAGYSIAFSPLTESDENYVTMYRVVGESRTELSMESFGFEGIPYNEQGWFDFVIEVWDKSRQQSREYRLSVYRGADIPSEFAGIAFEGPAGNTHLGVYYANPTVWFAETAAGDQEYAMFKVGTPLPNGVAVQSVKIWIDGEASEPGTESGYYKIPIENGAVVVFQATNGRSFAYRIEAIPSFAPELMNVKAMTPSFGDLSTVEFNVAGEGTLVVPEQYSSIRLRPYLVNDLSSVQVTVDGQTVKYGYGSRNSVLVSVEDGKEIEIVLYSPSGALSRTYKLTLNPPLSGENDFESFGFLGTAADGVIDPVNHTVNVTLPYNAEVTALVAKFVLSANAAATIDGIAQASGSTSNDFTDPVAYRITAENGDFQVWTVTVQREQSSNANLASLAFSNDLSIPPPYFEEVINLTARVDYGTKYLTIYATTEDPLSTITASGYPFSGGQATVPLTAVGAPGNIIPITVTAQSGATKTYQVKFIRDNTALQGVQVNGSSVEEFNSDVTTNFFLGNILARPDGKLEVKSVYDTSAAKIVYKVKSSSSEDWTEIVSTSGTSLLPVAPGMNDLKIIVKAADGAAIQTVYEFSVNITTAEDALPEEFDQLNFVVNGVDVPLTPVFDHTVYGYRVVRFAAEIAAIPSTLALHAVTNASLSEVSINDESLYWSEPGSQEDYSLSASSDGYYLYQLNYVSSETNTIVELALLVGDHPLPEDEPTNVSNIWIRAMDNYFYPDEQSGEIELPNSVSSGELTLGTEFDYNYAEVTLNGNLVEEIYGNTYELSGLLPGWNQLTVRVFVPTGTFYEDHVYWIWRNPVLTVKNASDEEVGSFELTRWGQEYSIFVPNGLTNYSIGAFNPNVWTLNGSPLEGETIPVTVSDGKGELELGYEGYGRDALPITLRLLELPEHVAGWTSSAGYGFQSLAWNRNGVGFFAVSQEYSTRINLSLESGYSWTLAPTVDYAGYSSNIYGLDNGGYQIYLHPGMQQYNLTITGPDNYSESYTLSLVYSDEPIISFINGSEPTTVSGISFGDATYFVLPESASDVYYHALANDTHSGITSGPLDTFPAFVANDTSFTDSAGRHFYRHPTYVYRGLPDELKIQVTAADDANHELETYSHNSGYGSVVNGYWRENEEMHPVSNVMTSIAFDSASTIELYNEDGSSVLDIAITEIDAETNVLRLERFVSMGAEYNYFVKITDTNGNSMVYNLKIYQSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIG7</accession>
    <name>A0A398CIG7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iron-containing alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_13765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01852">
        <property type="protein sequence ID" value="RIE01852"/>
        <property type="gene ID" value="D3H35_13765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990362">
        <property type="term" value="F:butanol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08187">
        <property type="entry name" value="BDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044731">
        <property type="entry name" value="BDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43633">
        <property type="entry name" value="PTHR43633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="3">
        <location>
            <begin position="9"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="388" mass="42411" checksum="4700F049B081A4D7" modified="2018-12-05" version="1">MNNFDFQNPTRILFGEGTLAKLGQEAAAYGSKVLLMYGGGSIKRTGLYDNVTAQLRERGIEVFEVGGVEPNPRLSTVRKAIEISRANGVQFILAVGGGSAIDAAKAVAIGVPYEGDVWDFFVQKAQAKSALPLGTVLTLSATGTEMNGNTVITNWEENLKKGYGSLHAYPKFSILDPTLTYTVPADQTMNGTVDMMTHVFEQYFSLTPDTPLQERMCESVLQTVIENAESALANPEDYVARANLMLCGTYALNGGFISVGMRGDWASHGIEHEVSGIYDIPHGTGLAIIYPNWMKYVYRERIERFAQYAVRVWKVNPDGKTDEEVALAGIQATRDFFTRIGAPSKLSEVGVGDEKIDVMAAEAVRFGPIGSFKKLNKDDVAEIYRMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIM0</accession>
    <name>A0A398CIM0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_14180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01922">
        <property type="protein sequence ID" value="RIE01922"/>
        <property type="gene ID" value="D3H35_14180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017179849" evidence="2">
        <location>
            <begin position="28"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="126" mass="13126" checksum="8DEFB853E7CA0689" modified="2018-12-05" version="1">MKKALRGMTAGASALLLFLLLSVTANAETGSGSAASPEPTATLPACHYMPPDDGQPIQVATTKTKTIQLSQTDSAVKSSDYENGAVKSGGLDTDGWQSYAWAWGAILFIVVGVNGKGLVSRRRGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIM8</accession>
    <name>A0A398CIM8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NarK/NasA family nitrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_15625</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03146">
        <property type="protein sequence ID" value="RIE03146"/>
        <property type="gene ID" value="D3H35_15625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="PTHR23515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="10">
        <location>
            <begin position="1"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE03146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="375" mass="39254" checksum="C79B02430268250B" modified="2018-12-05" version="1">MSASFVVWNLFSPLATRIQEMYGLTTIEKSVLVAAPVLLGSVLRIPMGIYTDRFGGKKTFAATMLFLIVPLLLASAASSYGMLLLCAVLAGMGGTTFAVSLTYVSRWYSPERQGFILGLAGLGNLGVAASSFLAPILVDRYGLDATFRILAVMITVVAAIFVLGAKEMPKQGAVRTFRQSMSVLRHRTTWYLSIYYFLTFGGFVAFSVYLPTLLKELFDMPATEAGLRTAAFVLVATLIRPLGGWLADRIGSGKVLTIVFGGIVLSSLAIGAALHHLTAFGLCCLVTGALLGLGNGAVFQMVPKVSSGNTGAVTGIVGAAGGVGGFFPPIVLGMIENATGTFAGGFVLLALFACLCLTIHYAAKKMKTAGRAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIN5</accession>
    <name>A0A398CIN5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_16485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03156">
        <property type="protein sequence ID" value="RIE03156"/>
        <property type="gene ID" value="D3H35_16485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="70"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="247" mass="27158" checksum="82D89025137F1A9B" modified="2018-12-05" version="1">MEEEKRTVRAVERALDVLLCFTAKEEWGLTEISARIGLHKSTVHRLLATLEDKGFLIRDEATEKYRLGLRMLELSAHLTRSDDPAVMLLPEMEGLMNRLGETITLYVRDRTERVRIQAVQSTQAIRRVAPVGARLPLAVGASSKVLLAFADPAVRALVLTDPSWPSAVDRSGYEKQLDEIVAAGYATSIEEREPGAAAVAAPIFNRSGKLVAALSVSGPSNRLTYEVMKEHASYIMEAARRMGAMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ13</accession>
    <name>A0A398CJ13_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_15130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02092">
        <property type="protein sequence ID" value="RIE02092"/>
        <property type="gene ID" value="D3H35_15130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="65" mass="7115" checksum="69C398690F50FE30" modified="2018-12-05" version="1">MQGKVKWFNAEKGYGFIETESGGDVFVHFSAIQMDGYKSLDEGQTVEFDIVQGARGPQAANVTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ16</accession>
    <name>A0A398CJ16_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flagellar protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_11440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03296">
        <property type="protein sequence ID" value="RIE03296"/>
        <property type="gene ID" value="D3H35_11440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022781">
        <property type="entry name" value="Flagellar_biosynth_FliO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04347">
        <property type="entry name" value="FliO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="184" mass="20872" checksum="EC67CFB8AE5B7F57" modified="2018-12-05" version="1">MSNWRLEGDLPSSSSTWDMLWVLFVLALMVGLIVLLLRFFAKRNRGWWMNRSLRSLGGLTLGTNKSMQIVEWNGRIYVLGVGEDVTLLESISDPDVVAALLAEHDTVNAAPAASLPIWLRKLTRQGGLTDETPKDVSEFTQPAGRSSFEQTLENRLRQLSERKQRMEQLLTDTKPEDRKNNNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ74</accession>
    <name>A0A398CJ74_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpsB</name>
        <name evidence="8" type="ORF">D3H35_11535</name>
        <name evidence="7" type="ORF">D3H35_25945</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000044">
        <property type="protein sequence ID" value="RIE00878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00878">
        <property type="protein sequence ID" value="RIE00878"/>
        <property type="gene ID" value="D3H35_25945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03313">
        <property type="protein sequence ID" value="RIE03313"/>
        <property type="gene ID" value="D3H35_11535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="232" mass="26541" checksum="BB9F9DB0D638ACBD" modified="2018-12-05" version="1">MAVISMKQLLEAGVHFGHQTRRWNPKMDKYIFTERNGIYIIDLQKTVKKVDEAYNFVRQLAENGGTLLFVGTKKQAQDSVKEEAERSGMYYINQRWLGGTLTNFSTIQKRTDRLHQLTKWEEDGTFEVLPKKEVILLRKEKDRLEKFLGGIKNMRRLPDALFIIDPRKERIAVAEARKLGIPIVGIVDTNCDPDEIDYVIPGNDDAIRAVKLLTSKMADAIVESNQGEETTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJD9</accession>
    <name>A0A398CJD9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00948">
        <property type="protein sequence ID" value="RIE00948"/>
        <property type="gene ID" value="D3H35_25650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="213" mass="22701" checksum="C23060AFAE547E18" modified="2018-12-05" version="1">MRSFGADSRLAAGYRERERSFGADSRLAAGYRGRERSFGADSQLAAGYRGRERSFGADSRLAAGYRERERSFGADSRLAAGYRGRERSFGADSRLAAGYRERERSFGADSRLAAGYRERERSFGADSRLAAGYRGREHSFGADSRLTAGYRGASSFSARVTGSRRVTGSASALSARIAGSRRVTGGASALSARIAGSRRVTGSASSFSAHVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJF0</accession>
    <name>A0A398CJF0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02450">
        <property type="protein sequence ID" value="RIE02450"/>
        <property type="gene ID" value="D3H35_17250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="181" mass="19416" checksum="4411D407AC7F3112" modified="2018-12-05" version="1">MLTPVLFGTSGLDSQASAAPLESWVSLVGIVLLTPIFQPEQNPHIREIVSSKWMSQLYVHLIRLIYSGAALLALIGLFVLYMKFNDCKVTLPLMFGTVASAVFLGSLGMLSSAATNNTAAAYMIPASFYAMNLVGGVRLGSFDLFSMMDGQYDQKIWLLASSAVMVSVSLVLSAAHSDRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJR3</accession>
    <name>A0A398CJR3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03556">
        <property type="protein sequence ID" value="RIE03556"/>
        <property type="gene ID" value="D3H35_10990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="137" mass="15193" checksum="96A7335940F525E5" modified="2018-12-05" version="1">MTSELYGGQVYYVKVFHYDEAGTGNYGLRVVQNDDNIAGDTLVLNSPITRLINYAGDQDVFVFTPSTTRSYVIKTTGSTDTVGVLSDSNNDPFADNDDSTDLNFSIAYTLTANQTYYIRVKAYNSNLYNASYTLIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJT1</accession>
    <name>A0A398CJT1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Glucose-inhibited division protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">mnmG</name>
        <name evidence="11" type="synonym">gidA</name>
        <name evidence="14" type="ORF">D3H35_24035</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MnmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01439">
        <property type="protein sequence ID" value="RIE01439"/>
        <property type="gene ID" value="D3H35_24035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PTHR11806:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00136">
        <property type="entry name" value="gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GIDA" evidence="12">
        <location>
            <begin position="9"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="GIDA_C" evidence="13">
        <location>
            <begin position="403"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE01439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="632" mass="70315" checksum="ECE4D632DEB977C8" modified="2018-12-05" version="1">MSYQAGNYDVIVIGAGHAGCEAALAAARMGCETLLLTINLDMVAFMPCNPSVGGPAKGHVVREIDALGGEMGRNIDKTFIQMRMLNTGKGPAVHALRAQADKFSYQHVMKETIEKTDKLTLRQGMAEDLIVEDGACVGVVTKTGAEYRAKTVVLTTGTYLRGKVIMGELMYESGPNNQQPSIKLSESLKNLGLQLVRFKTGTPPRVHGETIDFSKTEIQPGDANPKYFSYETEYMLHSQTQLPCWLTYTSEETHRIINDNLHRAPMFSGAIEGTGPRYCPSIEDKIVRFADKPKHQIFLEPEGRNTKEYYVQGLSTSMPEDVQLDILRSIPGLERVEMMRTGYAIEYDAVVPTQLWPSLETKIVPGLFTAGQINGTSGYEEAAGQGVMAGINAARKAQGLDPVVIDRSKGYIGVMIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTPLGYEIGLITEERHKKFLDKKDRVEKEIERLKETKFRPDEAVQAMLAECGSAPLQNTVDGVTLLRRPEVSYANLESLYPSSIDLTDEMKEQVEIQIKYTGYIEKQLLQVERLEKMEKKKIPETIDYDIVHGLATEAKQKLNKIRPLSIGQASRISGVTPADLSILLVHLEHYNRVTAARGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJV8</accession>
    <name>A0A398CJV8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_30105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000064">
        <property type="protein sequence ID" value="RIE00167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00167">
        <property type="protein sequence ID" value="RIE00167"/>
        <property type="gene ID" value="D3H35_30105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="51" mass="5642" checksum="A2158F92DDF88CFE" modified="2018-12-05" version="1">MDVQMPEMDGFEATSIIKSRPGAHPVIVAMTANALFEDKNFVLKTAWMTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJZ9</accession>
    <name>A0A398CJZ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDSL family lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02630">
        <property type="protein sequence ID" value="RIE02630"/>
        <property type="gene ID" value="D3H35_18285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="14"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="208" mass="23533" checksum="CC2EB40FB7AAE95F" modified="2018-12-05" version="1">MTRIEENEVVLFQGDSITDCGRDRGDPYSLGNGYAQFTAAEFGRKYPEKNVRFLNRGISGNRVVDLERRWQEDCLDLAPTWLSIYIGINDTWRRYDSGDATSTQAYEDGYRRIIEHAKQSLDAKLVLIEPFVLPVPEDRKGWREDLDPKIQVVRELAREYRAAYVPLDGLFAAASARQTPAYWAGDGVHPSPAGHALIAKAWLEAVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK92</accession>
    <name>A0A398CK92_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02720">
        <property type="protein sequence ID" value="RIE02720"/>
        <property type="gene ID" value="D3H35_18905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="200" mass="22685" checksum="27B92247F5983CA9" modified="2018-12-05" version="1">MIIDEINQTHKDINDLNDAASALFRIPIFFSHQNLFTLGPPQPPLSEQQRFIIRMFKEIKKVLLFPRTIPNTDQYPNTTLENIRRIIKSSYGMTAALLKPTGPTALGEPYSPFLQIEPSMAYQYGLPLLLVKESTILAGGVWGDAGPLAPFTPLIWFSNTTTVDEFFDSVQWKEALQNWAGQVRSGYFIQTGPEFHYQCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKA1</accession>
    <name>A0A398CKA1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01629">
        <property type="protein sequence ID" value="RIE01629"/>
        <property type="gene ID" value="D3H35_25140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017395298" evidence="1">
        <location>
            <begin position="23"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="441" mass="49348" checksum="A1B194213F96A64C" modified="2018-12-05" version="1">MKMKKIGMVLLSVLFTLSVLSACSSNDNNNKESSGQASSSNGSSKDVVKLTFWGGVPAESGPQEIVDTWNKEHPNIQVTYVRYVNDDSGNLKLDTALASGQSVDIFANYTKPLLTKRASSGSALDLSQFNDYNIDEKMGPGAKEWAVDDKYYALPTKRNLHFVWLNKDALDKAGLPVPTDWTLADVEQYAKALKTDTRWGYSTFPFWRDIVTFDGSLAVQGYVKEDGTSNLGVPIVRDALKLNYDMMHTSKVSPPISLIETTKMNLIAEFLGNKLAMLNAGEWVFRDANNLKDYPRDFKVAFAPLPRVTKEQDDFRYLGGLGDAIAINAKSEYKEEAWEFLKWYADGGMLPQASGGRIPASKDADQAKAIELLLGDLKDKYDVESLERILSNDLPTFQVTLPQEVIDLRGDEFDKYYINAQSLDDTINNVVKRHNEYLKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKI2</accession>
    <name>A0A398CKI2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03223">
        <property type="protein sequence ID" value="RIE03223"/>
        <property type="gene ID" value="D3H35_20645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="115" mass="13382" checksum="EC1221E87940C852" modified="2018-12-05" version="1">MDEKIARFYQLKKQHKEIEQEMADLRGDILTLCSGLDVTERDAGDFRVKLIGQERREYDDQKLYNALPDASVWRLLSKADATKIAALIKLNVISEEVIRETYTIKKVTLLQVERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKP3</accession>
    <name>A0A398CKP3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_28335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00457">
        <property type="protein sequence ID" value="RIE00457"/>
        <property type="gene ID" value="D3H35_28335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="5">
        <location>
            <begin position="491"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1051" mass="119216" checksum="E3FB9B84DD533105" modified="2018-12-05" version="1">MLGALADRQWRHVWELKEWEVRLAEYVKPGVYTFQGDSEKGAPSRFLTGSPGTTYFLSLKVDIPAECGDDPVGLIVEFGGEGLLRVNGKPYHGLDSNHTFVPLLPGTVGDSPFFEIELFDPIPEPEDPLNKQAVIRKPIHSIRALLVAVNRPLQSFLRSLTVAKDALLRLPERDPLAGSLRRAIQEAMNRVERRGWEPEPDDAFWQEAERELREKVRNIAPDRKPYGRMRMVGQSHIDVAWLWPIRETVRKTSRTFSTVCTLMDEYPEFLYSQSQPQLYAYAKEHYPELYERIKERIAEGRWELVGGMWVEPDLNLPSGESLMRQLLHGQRFYMQEFGKRTTVEWLPDTFGYCASLPQILQHAGIRYFMTSKLGWNDTNTFPHDLFHWKGIDGTKVLTFLNHGLNEHTTPADIQEHWDSYRQKDRHPDQMLLYGHGDGGGGVTREMIEYAQRPDLMPGLPQAEFGTAIGFFEGVGEDRADLPEWRGDLYLELHRGTFTTHARNKSWNRKAELLYRDAEVWNELGRPYAAASQHASFKSSLEEGWKLLLLNQFHDIIPGSSITEVYETSANEYERVFELGDGALKQGIDALAEVISAEGEGIPYHAFNSLGWMRDEVVTISGGAELLGMAAFDRDGNALPCDLLPAIDEKDGAYALAVRVSSIPAFGYATFWLKPVGAAEAVAPVGLEWAGEDKLNRWETEFYVLEFDRTGTIVRWYDKAEDREWLAPGSRGNELQLFHDKPTLWDAWDIDPDYEKNPAEAAELVSAKAIARGNALDLLRFEWKLGRSSVYQDVVLYRHEKRVDFRTRVRWEESHKLLKAAFGFDLTTDKAAYEIPFGAIERPTHRNTSWEQAQYEVCGHRWADVSESGCGVALLNDCKYGYDIREGTMRLSLLRAPKWPDVTADQGWHEFVYSVYPHGGGWREAHVARKAAELNSPAAVRLGVSGKGANGGGAAFGGSLPDRHSFLRLESEHVVLDTIKATEDGDDTILRFYESSGGRERIFVGWPEPLSRVVAVGALELEEEDAEELTLRDGGFELSFRPYEIKTIKLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKQ2</accession>
    <name>A0A398CKQ2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rpsR</name>
        <name evidence="7" type="ORF">D3H35_24175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01458">
        <property type="protein sequence ID" value="RIE01458"/>
        <property type="gene ID" value="D3H35_24175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="112" mass="13167" checksum="8F06E4AECAC5C7F4" modified="2018-12-05" version="1">MSEQQAAAPAAREERTYTPRENRGPGGGGDREQREPRKFRRGRNKRRKVCYFTVNKIKHVDYKDLDLLRKFISERGKILPRRVTGTKAKYQRMLTVAVKRSRQMALLPYTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLV7</accession>
    <name>A0A398CLV7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_10040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03633">
        <property type="protein sequence ID" value="RIE03633"/>
        <property type="gene ID" value="D3H35_10040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017471525" evidence="2">
        <location>
            <begin position="29"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="492" mass="54882" checksum="486BED748206B66C" modified="2018-12-05" version="1">MKVFHRKRLTALFALSATLMMTGCNIGGTENKSETEKATIKVMYYDERSFFDQFGMLYSALHPEVEFQIVTQQYNNSEPGKDLEAEMTKFIDENKPDILFLSSEQLTKYGNDGKLLELDSMVEDKKFNKETFIPGLIDYFKELGGGKLYGLTPNYYSQVLYYNKDLFQKYSVDLPTDKMSWEQMLQLAQRFPTTGSKEERVYGLSLGYNSDPYQFGSMIGASSNLNFVNPTTAQVTINTDAWKKTFDLAFKALKSGALHTQDPSAPSATSSYEDYLLQDPFVAGKVAMKLEGNYLIDQIKQAQQQVKDKAIKNWDMVTVPVNPQAPDSSPNVGLSQFFAVSSQSANADAAKEFLQYVMSDEYARVTSKLNRGNLPVRTTYYKDDEGHNMKAFYTLKPTESTIYKNYDKLPSDFLMQFMTIAQQELKSAFDGQITLDDALNNAQTKGQAALLQGQAQQKDKEAAAPASGQASAQSSVQAGVQAEASSSSAEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMF0</accession>
    <name>A0A398CMF0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_12335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03442">
        <property type="protein sequence ID" value="RIE03442"/>
        <property type="gene ID" value="D3H35_12335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="5"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="249" mass="27333" checksum="6F9564CD912A0333" modified="2018-12-05" version="1">MSAYFRLIAFDFRLYLRDWMTIFWVLVYPVLMLLIFGSLFGEEAGADPGTRYIDYYVPALCVMSVLSVGVFTLNINMITYRESGILRRFRVTPLRKSAVLVSHFIQGLVLIVLGAIEVIVIAKLVWNIDITFGGAALLLLVMLIGAIGCFCLGFALSGLVSTPGAASGVAMAIFFPMLFLSGIAMPLSIFPEFMKAISKAIPMTYFVELAQGVWQGHSVSGYGAQLAVLAGFAIVCGVLALRLFRWENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMJ2</accession>
    <name>A0A398CMJ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">50S ribosomal protein L33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03675">
        <property type="protein sequence ID" value="RIE03675"/>
        <property type="gene ID" value="D3H35_10270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="86" mass="9357" checksum="D1D43379EE6E97C0" modified="2018-12-05" version="1">MSRVSASEARKLIGRQIYAVRKDGSVVTGKLVRVQSNRLVLEQPKGKNVQTKAIIPLVLFDLLAIGTTPFGFGFGGGFGFDGFGWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMK1</accession>
    <name>A0A398CMK1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03685">
        <property type="protein sequence ID" value="RIE03685"/>
        <property type="gene ID" value="D3H35_10325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017361355" evidence="1">
        <location>
            <begin position="29"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="367" mass="39270" checksum="60EF016AC291FF15" modified="2018-12-05" version="1">MHKRYLAGTAVLALALGLLSGCSDNSKNEESKATDEGSSAVSIAIDQSALAVQSWKMDNSHVVPVAGKVLSDGQPVSGVEVNLAGKRNVTTSEDGSFEFMVDRSIPQTLSVSVTSAEQAAIAGKSVGQSAKTALLAAKSSVDIYYPVQVVDVKASANDPEAVEVHARAVVEEGQDFPVTALYNYAIRGTVKAADGSPVKDAIVSFVRDNGEGWSRSEPSNDKGEYVLYYSPEEDEDLSLNVHVGETKYSLPENRVYRFPEDTSVQTDITLPAEGNIITDKPPTLVSQAAEGAVYWSVMIGVNADSPYTVTLPDKDGSFVLTISKKAWEQAPSFFETRVSRFLLKPIAAGDTVSSADILLLRRTNRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMQ9</accession>
    <name>A0A398CMQ9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Demethylmenaquinone methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.163</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">menG</name>
        <name evidence="5" type="ORF">D3H35_03915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.163"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04646">
        <property type="protein sequence ID" value="RIE04646"/>
        <property type="gene ID" value="D3H35_03915"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="107"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="239" mass="27080" checksum="9A7FDF2FAF226FC0" modified="2018-12-05" version="1">MIDANSKDHVHSVFESIAPKYDLMNDILSFRRHKAWRAFTMRKMNVQPGQKSLDLCCGTCDWTISLARASVNGETVGLDFSRNMLDIGQAKVDKLGLAKQITLVQGNAMELPFADNTFDYVTIGFGLRNVPDIVQVLKEMKRVVKPGGKVVCLELSKPTWQPFKGIYYFYFEKLLPLMGKWFVRKYEQYRWLPESLAVFPDLQALAELFRTVGLRGVKAYPLFFGVAALHIGTKGTDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMV4</accession>
    <name>A0A398CMV4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000034">
        <property type="protein sequence ID" value="RIE03622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03622">
        <property type="protein sequence ID" value="RIE03622"/>
        <property type="gene ID" value="D3H35_10630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="88" mass="10536" checksum="6CF3F6A8432D89E8" modified="2018-12-05" version="1">MAAQAHALSEKISETQRELAADTSRIEATKQELQKRYEDAERIRQELERRSDDRELLDRKELLEKEISELKRKAGIWRRKARTSKRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMY5</accession>
    <name>A0A398CMY5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3533 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_25610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00941">
        <property type="protein sequence ID" value="RIE00941"/>
        <property type="gene ID" value="D3H35_25610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="2">
        <location>
            <begin position="17"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="384" mass="40106" checksum="602CAFB41D055CA2" modified="2018-12-05" version="1">MNTVRLFFKRPTTWIGLATALMFQVIFSVVWMTGYDGVSDRMGNLKVGIVNEDPGFGAKIVEQLRTTLPVQTEVFADSQSAEHALNERELQMVIRIPAAFSADVATPDKKAELEYLLNESNPATIKSMMTGVSSQVTAAVNKIAVAQGVQGALSTANVPADQAANSASALSERVVSNLVTTNKVNGMNNQMVPMMLVLASYVGAMIMGMNMEQSSMALAGQAGRWQRFAARGIINLGASVVVSLVGATLVSAFGGGAEQGFGTLWLLLFLIMLTFLFVSQLFLLLLGMGGMLLNIVTLSAQLVSSGAMVPRELLSGFYRGLGDALPATFAVEGTMNVMFGGPGIGHAATGLLIIAGAALALGALAVAAKRGRAPQAIPSAAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNE3</accession>
    <name>A0A398CNE3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_22040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01101">
        <property type="protein sequence ID" value="RIE01101"/>
        <property type="gene ID" value="D3H35_22040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="25"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="134"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="329" mass="36528" checksum="E48E1607D8197E17" modified="2018-12-05" version="1">MRKLKVGMLSFAHGHAFSYLYELMRMPNVEVVGIADRDRERVSAVLEQYKLPYFSDYRELIGSDVEAVIICSENAYHTEMAVEAARQGKHILCEKPLGIGIPEMDQMIREAKANGVQLMTAFPCRFVPAVVEAKKAIDKGEIGKVVAIRGTNRGTKPAEPWFTNKELSGGGAVLDHTVHVTDLMNWFMSDSRVCEVYALAETLYHDIDVDDAGMVHMRYDNGVIAVLDPSWSRPKSYPTWGDVTMEIVGTEGSISVDCFKQSFDLYRDEVMKANWSYFGDSMDHYMLKAFVDAIFSDSPVPVSGEDGKLSAVVALAAYNSAALGQPVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNG1</accession>
    <name>A0A398CNG1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YqzM family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02789">
        <property type="protein sequence ID" value="RIE02789"/>
        <property type="gene ID" value="D3H35_19325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="48" mass="5498" checksum="82C8F83B45314633" modified="2018-12-05" version="1">MSNAQDPRLHINEEPRDDFKDLMFGFGGMFGFMFVVFAIAVIVKFAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNG8</accession>
    <name>A0A398CNG8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_08770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intimin/invasin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04035">
        <property type="protein sequence ID" value="RIE04035"/>
        <property type="gene ID" value="D3H35_08770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044016">
        <property type="entry name" value="Big_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003344">
        <property type="entry name" value="Big_1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001220">
        <property type="entry name" value="Legume_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19077">
        <property type="entry name" value="Big_13"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00139">
        <property type="entry name" value="Lectin_legB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00634">
        <property type="entry name" value="BID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017317516" evidence="3">
        <location>
            <begin position="28"/>
            <end position="2446"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="977"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="1165"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="1353"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="1541"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="5">
        <location>
            <begin position="2293"/>
            <end position="2365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1304"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1456"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1492"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1644"/>
            <end position="1664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="2446" mass="256643" checksum="9E58BE97B0233556" modified="2018-12-05" version="1">MCRSFNKSALLLLIAVLIITSMGFAPAKARASAPETRYLTLKHDDFSAAQDVDGIIPGKSPEKWLQRNGNAALATDDQGRKVLRVTPNQTNAIGSAFHGNMISFGKDRSFSTYFTFRMSGIANNAFAAGDGLVFSIQTLSKEAGVKGGGMGYGSMKRSFGIEFDTFANSATVASDPLDPKAIGVNIGGTPNSSRGGTAVTYDTSHIAVVADGNVDHSKSTTSPKGKVFPASVGGSTSNPSIIATPTAGETVPIYNFKTADTGTWATNDAYPFYNGEIYHAWIVYNGPTDTIEVYMGKNGTFDTSKLKIKKSGLGLREYLEQDEAYVGFSAATGSAYENHDILKWYLNNNELPIEPENPDYNYEAAPPLISITSTDYAVYGSTTSTTSRIITAQLKNYDGSDWTGGPYPVTFSLFKEEAAKSYTVTKTDGSTQVVSLKPRVDDTRVALKGETRRTNSDGSSMRYASVMSDANGVATIQISNTLPTAINDSNVKAIVGDHFGTGVYGGGAYDEKPVTFAADAVPPTITSAAVDVSNPNHVKAFLSEYVLYPTDRNHPENWTEDNSATWNANGFKVLIPDPSSPGTYISVPATIVGGSGSPDEPLVLELAGGKVVPFGYDVKLQYVKADGSLQDAAANLVQDQTLFVDDYPFTPKGAAVVNDQDRKTVEVNFDFPVRDNAVIPGSFKVYYDTGSGKTLAAVTGAVSDGTDPNKLVLTLGTAVPAGATVTLDYVVPGSGGKVTNVTIDGLSAGHHTLKALTDFNVANQMAPNQASVIPDANRNKVKVVFDSEVELQGVAATLAAAFKIGISSQGDLIDVSNVVIDSSDASGKTLILTLGGANLPSGGVPYGDVVKLNYDSTIASVDVKEKNGSERSLEWLTNFPVANQQILNVVIVSPADGSTTNNPNTVITGTSEPGSTVTVVVKDSNDAPVDGEVEVDSSGNWTFTPDDPLTDGTYTVSAEATDAAGNKGTDTSAFTVDTEAPDVDITGPTNGSITKDPNTVITGTNEPGTTLTVVVKDSNGDPVDGEVEEDGSGNWTFTPDEPLPDGTYTVTVEATDGNGNEGTDTSTFTVDTVKPIIVIVSPADGSTTNNPNTVITGTSEPGSTVTVVVKDSNDAPVDGEVEVDSSGNWTFTPDDPLTDGTYTVSAEATDAAGNKGTDTSAFTVDTEAPDVDITGPTNGSITKDPNTVITGTNEPGTTLTVVVKDNNGDPVDGEVEEDGSGNWTFTPDEPLPDGQYTVTVKAEDSNGNEGTDTSTFTVDTTKPSIAVVSPADSSITNNPNTVITGTSEPGSTVTVVVKDSNDAPVDGEVEVDSSGNWTFTPDDPLTDGTYTVSAEATDAAGNKGTDTSAFTVDTEAPDVDITGPTNGSITKDPNTVITGTNEPGTTLTVVVKDNNGDPVDGEVEEDGSGNWTFTPDEPLPDGQYTVTVKAEDSNGNEGTDTSTFTVDTTKPSIAVVSPADGSTTNNPNTVITGTSEPGSTVTVVVKDSNDAPVDGEVEVDSSGNWTFTPDDPLTDGTYTVSAEATDAAGNKGTDTSAFTVDTEAPDVDITGPTNGSITKDPNTVITGTNEPGTTLTVVVKDNNGDPVDGEVEEDGSGNWTFTPDEPLPDGQYTVTVKAEDSNGNEGTDTSTFTVDTTKPSIAVVSPADGSTTNNPNTVITGTSEPGSTVTVVVKDSNDAPVDGEVEVDSSGNWTFTPDDPLTDGTYTVSAEATDAAGNKGTDTSEFTVSLTYFIDLKANPDVLVADGNSISVLTAKVTDSQGNPVSGVDVDFSAFLKNTSTPKGTFVDAAGQVIGTPRATTVNGVATIRFKSEAIQSVTSVKVDIKAAVHDTVHGIHAEDKILVTFEPAVVSGIITGGANHQPLAGVTVTLLDANGQPIPGRTAVTDEDGHYVLPITEGNQIYKIQVSQTVGTGSSAVVVTYVQEVAVDDGISGLGQEFVSDQTIAGIIGGKRPDGTIQPLDFGSFVGNDSAGTNPAFGLFLKDGNQYVTSSNGTVTVPGESDGFSINGQGVFVAGGLTAGTTYQLEVRYYYDVANGNGGVSREFIVIAKKTVTVSANGEMNINEELIDPFGVITDSVTHAIIPNAHVVLKYADTTRNRNKGIVPGTTVVLPTLAGFLPANNANPQNSDTGGNYAFMVFGNTDYVIEATATGYQKYRSPVISVEQDIVRWDFEMNPIVPTSGGGVTVTPPAEKVTADVTTNIVVERSTYEEGSEAPVVILYKNEADKPLAAGQLKVTLPDNVIVIDADGGKVTGNVIVWEVKDLAAGQVASHRIRVKFPNIDSVEKVVTLKAEFVVDGELAHPENAKSSVKVLLFSNRFGNERHTRFVMGYPDLMFKPERSLTRAELATIIAHLLGEYDSGTTKNYSDVPKKFWAYKYIQTVSRHGIFSGYPMEPSTLTTRYREKNWRSLWRNTCSWMWQNRFNRALEMRRAAGRLRTSKRLTGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNP2</accession>
    <name>A0A398CNP2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsG</name>
        <name evidence="11" type="ORF">D3H35_02220</name>
        <name evidence="10" type="ORF">D3H35_29425</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000062">
        <property type="protein sequence ID" value="RIE00282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE04986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00282">
        <property type="protein sequence ID" value="RIE00282"/>
        <property type="gene ID" value="D3H35_29425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04986">
        <property type="protein sequence ID" value="RIE04986"/>
        <property type="gene ID" value="D3H35_02220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE00282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE04986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="156" mass="17762" checksum="53DFF848A539B604" modified="2018-12-05" version="1">MPRKGPVPKRDVLPDPVYNSKLVTRLVNRIMIDGKKGVAQQLLYDAFNLIQERSGKDAMEVFEAAIKNIMPVLEVKARRVGGANYQVPIEVKPERRTSLGLRWLVNYSRNRGEKTMEERLAAEILDASNNTGAAVKKREDTHKMAEANKAFAHYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNQ7</accession>
    <name>A0A398CNQ7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_19935</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 7">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02889">
        <property type="protein sequence ID" value="RIE02889"/>
        <property type="gene ID" value="D3H35_19935"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011278">
        <property type="entry name" value="2-MeCitrate/Citrate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01800">
        <property type="entry name" value="cit_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="371" mass="40322" checksum="F96DDEA4C4102315" modified="2018-12-05" version="1">MTATKGLEGIVAAASSISSIIDGVLTYRGINIDELAEQATFEEVAYLLWHGKLPTQSELDGLIAQLGEFAEVPSEVIESLRLYPKDSNSMAALRTVVSSLALYDGEANDMSREANVRKAVKLQAQLPTVVAAFARIRQGLEPVAPKKGVGVAYNFLYMLSGKEPAQVAVEAMDKALVLHADHELNASTFAARVTVATLSDIYSGVVSAIGALKGPLHGGANEAVMVMLDDIGSLDNVEPYIQNKLNNKQKIMGFGHRVYKDGDPRAKHLQQMSRQLGELNGDSTLYEMSVKIEDLVTGQKGLKPNVDFYSASCYTMLGIPRDLFTPIFAISRVSGWTAHVLEQFEDNRLIRPRAEYVGPVGQHYVPIAKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNW2</accession>
    <name>A0A398CNW2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_20355</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02959">
        <property type="protein sequence ID" value="RIE02959"/>
        <property type="gene ID" value="D3H35_20355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="16"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="397" mass="41956" checksum="B2BB00F8CAD82722" modified="2018-12-05" version="1">MQTKQVIESKRISGWIMFLLASACGLIVANLYYAQTLVGPISVATGLSSTAAGLIVTVTQIGYVLGLLFIVPLSDLIENRRLAAISLIVAVCALLGATFATTAPLFLAASLFIGLGSVVAQILVPYATYLSSEEQRGRVVGNVMSGLLLGIMFARPVASFITSIWGWQAVFALSAIVIASLTVLLSRVLPERMPSPTMNYGKLIVSLGVLLKQTPVLRRRALYQAFLFGAFSLFWTVAPLRLADDFGMSQQGIAWFALAGVGGAIAAPIAGRLADKGWSGFLTGLAMIVAVLSFLLTYLFQGHSTTSLALLVIAAITLDMAVSGNLVLGQRAIYSLGSEARGRLNGLFMSIFFIGGAIGSSLGGWSYAHGGWSLASLIGIVMPLAALLYFFTEKKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNW7</accession>
    <name>A0A398CNW7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02438">
        <property type="protein sequence ID" value="RIE02438"/>
        <property type="gene ID" value="D3H35_17185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="312" mass="32465" checksum="1CFC3EE048E2C3C1" modified="2018-12-05" version="1">MLTQMKVCGDGQPDAMPVSALRLHRSLAWPVGQLEARLPASFRAPSAGTSISASAASADGWQTLFTGQTLSVSSGLWGARLLVEEASGPLTRSFVNKAFRSVTAGSMIHELSGDVSCSVSGPGTLFPYKTVLANRSALDHICEIARLSGFIVYTDVEGKLHAGMAPVTPAGTLTASDPIVDFRAEAEPFWQNSEALYGAGALGLHGPGAETWVLKDNSSLSSGSGSSEALLPSLKTLESVALVAEANAQSLREARGRITVVYAGPPPADLGQLLTLTGFQSGNGIARVYAIDVRWNAEAGLLTQLQLRSIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNZ2</accession>
    <name>A0A398CNZ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00644">
        <property type="protein sequence ID" value="RIE00644"/>
        <property type="gene ID" value="D3H35_27145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="105" mass="11944" checksum="B07F05B4D57443D1" modified="2018-12-05" version="1">MTEERRNKALSVTISDGWTEERRNKVLSVTIYGGLTGERRNKTLSVTISDDWTEERRNKALSVTISDGWTEERRNKALSVTIYGGLTGKHRNKALSVTISDDWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP26</accession>
    <name>A0A398CP26_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4-hydroxybenzoate synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04122">
        <property type="protein sequence ID" value="RIE04122"/>
        <property type="gene ID" value="D3H35_07880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="190" mass="21409" checksum="E37351450D0995DC" modified="2018-12-05" version="1">MFDYLHGLLFDILLTTDGRTTDMLETLMDDKMTVKVIRQEQLDDREAAPFGQPSGGPYYVRESVLIGEKSGFVVSHNIALVCSPHVPLPLFEAISSKQEGIGKTISALGLQTLRKLTEYGWKSADEAVDLFDRPLALQFPRMKDKAPYKKYTMSFGPVPGILLLEYFNPGIVMHRVQRTIVDNQKKDDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP38</accession>
    <name>A0A398CP38_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21735</name>
        <name evidence="2" type="ORF">D3H35_21785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01646">
        <property type="protein sequence ID" value="RIE01646"/>
        <property type="gene ID" value="D3H35_21735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01647">
        <property type="protein sequence ID" value="RIE01647"/>
        <property type="gene ID" value="D3H35_21785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="78" mass="9221" checksum="C0014B332A8ED2D8" modified="2018-12-05" version="1">MMPIYERLAELWFIRRVRPFSAQEQADFEHCLAVNASHISRLSGLYNLSLLASMTEDKDWQHEICREIEKIEGKEIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP53</accession>
    <name>A0A398CP53_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_22455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01667">
        <property type="protein sequence ID" value="RIE01667"/>
        <property type="gene ID" value="D3H35_22455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="334" mass="35216" checksum="DF209867201C654B" modified="2018-12-05" version="1">MERSKRAWCTGIVLLTGALVLIVVSLNTGTVRLSTQELWHTLLGSGTPDSKIVLLEYRLPRIAITVLAGIGLGVAGSVLQAVSRNSLADPGIVGLHAGAAFGLIVFVSFFRTMEGPSSLLIPLFTFVGGTAIALLIFILAYDRYKGLMPIRLILVGIAMEAGFSAATLFLSLKLDPDTYAFAARWLAGSVWGRDWINVAALLPWIVVLVPYIYSRSRTLDIFALGDDIATGMGNSVTLSRIGLLAAAVALSCASVSMAGGIGFIGLIAPHIARRLVGPMHRHNLPISALIGTTILVASDTIGRSIFHPNAIPAGIVVAGVGAPFFLYLLLKSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPD5</accession>
    <name>A0A398CPD5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Type II secretion system F family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_23555</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GSP F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01351">
        <property type="protein sequence ID" value="RIE01351"/>
        <property type="gene ID" value="D3H35_23555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="70"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="272"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="403" mass="44832" checksum="EC25232B52C9B8C1" modified="2018-12-05" version="1">MAAYKYVAVDSSGSYRKGSIESQSAQQAIALLRSKELRIVELVDPQRSVWTRDIPFLEAKVKKDQFTLLCRQLATMYSARINLVDAIEIVARQTTSKPLRRVLNEIVNDMRGGSSFSAAAAAHPKIFGTVFVHMIEAGEMSGKLDEMLQRIAIMYEKEQTTKGKVKSAMIYPIIMSIAISLVVIFMMLFIVPTYIENFKSMGVELPLPTKLVVGLSEFLQHFWYLILLGIAIIVPAFMYFRKTEQGKYQIDAYKLKVPIFGQLWHKQAIARFSRTFSSLHAASVPMLQILTILSKVVDNEAIGKALLQSRENVSSGHSLIEPMQASGNFPVMVLEMIAVGEKTGTLEVMLGKTAEYYEADVDMMADRLKALIEPLLIVGMTVAVGTIVLAVILPSFSLMGSMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPL2</accession>
    <name>A0A398CPL2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0637 protein D3H35_01305</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_01305</name>
        <name evidence="2" type="ORF">D3H35_07005</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0637 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000012">
        <property type="protein sequence ID" value="RIE05311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04342">
        <property type="protein sequence ID" value="RIE04342"/>
        <property type="gene ID" value="D3H35_07005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05311">
        <property type="protein sequence ID" value="RIE05311"/>
        <property type="gene ID" value="D3H35_01305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01851">
        <property type="entry name" value="UPF0637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009403">
        <property type="entry name" value="UPF0637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06335">
        <property type="entry name" value="DUF1054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021332">
        <property type="entry name" value="DUF1054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="236" mass="27017" checksum="7C937F1F71B60FDC" modified="2018-12-05" version="1">MFPCYNESSCFRKWFVRRRNDDERNRVNKFVRGFVPADFEVFDIDGLEPRMTALIEQVRPKLHQLGDQLSPFLSDLCGETVYPHVAKHARRTINPPNDTWVAYAPSKRGYKALPHFQIGLWGSHIFIQFAIIYECESKGAFAERALAELASVRRSIPASFVWSKDHMIPEGLRHGKLADEELADLFYRLGSVKAAELTCGIHIQKDDPIVSDESAFLALAEKTFKKLKPLYRMAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPZ6</accession>
    <name>A0A398CPZ6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02818">
        <property type="protein sequence ID" value="RIE02818"/>
        <property type="gene ID" value="D3H35_19490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="102" mass="11072" checksum="78D0049BC217BFF2" modified="2018-12-05" version="1">MSLPNVPNITPTINVTTKDAVNLLLVSIALEEISLAHIMNAEAEKIQFILGTLPGTTHPGSIGEVLHINKDVRATLNEVVLKEVLLQMKLNSVLDAFPQHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQL3</accession>
    <name>A0A398CQL3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="5">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_05050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04835">
        <property type="protein sequence ID" value="RIE04835"/>
        <property type="gene ID" value="D3H35_05050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="PTHR11845"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="6">
        <location>
            <begin position="36"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="205" mass="23587" checksum="5CF09B3B59034E46" modified="2018-12-05" version="1">MEQWSNERLSRQIAFITEIDKLKTVLRHSYLMDGSRRENTAEHSWHVSVIAMALLEHAGDPAPDLNRVIKLLLLHDLVEIDAGDTFAYDDKGYADKEERENAAARRLFGILPDDQRDEWLALWREFEDGVTIESRYAAALDRLHPVIHNYYTGGVSWKKNGIVRAQVIRRLDPLRTVSEPLWHFALDMLERAVALGLLLDDEAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQQ1</accession>
    <name>A0A398CQQ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000035">
        <property type="protein sequence ID" value="RIE03599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03599">
        <property type="protein sequence ID" value="RIE03599"/>
        <property type="gene ID" value="D3H35_10695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="359" mass="40507" checksum="D49F923BE0B4379A" modified="2018-12-05" version="1">MQNHLDETFGSDSIFYQSQITEAVDKLIDNRVIVIEDDLFVVEGEDEGLTARHEQAVDEVRSMITDAFFTPSLNPIEPEKEDTWDKIEHLAKTSSALAVTGGWGSLVSFSYRQIDYTRIDRKRLNVNFSERTAVKKSIYPQGHLSGLFKSLREPGIDLSRFVLSVDLIDPWFELRKIQVISRADYQEDDIASIHVTLEYGNQVKSVLLDSSASTFNLEWNSILDNGEVRRQAVYRYKVLSPCRRDRAPAFAAISRHYRTRRRCGNPSKRAVFHRPGPDSGVEFSMGALFACRGSDAIRGSRASDQPSGQLCAEQGNVTEASWKMFVMDSGKTVSATKSFIARLIFGTLSCPGWRRMRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQV3</accession>
    <name>A0A398CQV3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="9">HTPA reductase</shortName>
            <ecNumber evidence="9">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapB</name>
        <name evidence="12" type="ORF">D3H35_04085</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="9"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04892">
        <property type="protein sequence ID" value="RIE04892"/>
        <property type="gene ID" value="D3H35_04085"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="10">
        <location>
            <begin position="5"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="11">
        <location>
            <begin position="132"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="9">
        <location>
            <begin position="166"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="100"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE04892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="267" mass="28846" checksum="0BE08780F64313AC" modified="2018-12-05" version="1">MSERIKVAVAGAGGRMGREVVKMVLEDEELQLVAAIARSAGPVDAGTLVGKPAASVIVSSDLESALTSSRPDVLVDFTNPQSAMPNTEIAVRLGVRPVVGTTGFTPEQMVQLDELCKEKGIGALIAPNFSIGAILMMKFSAMAAKYFPHVEIIEYHGDQKLDAPSGTSIKTAEWISETRKELRQGNPKEEEVIEGSRGGYYNGFRIHSVRLPGVFAQQEVVFGAFGQTLKIRHDSYERAGYMPGVNTAIKKIMGVTGLVYGFEHFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR34</accession>
    <name>A0A398CR34_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02287">
        <property type="protein sequence ID" value="RIE02287"/>
        <property type="gene ID" value="D3H35_16315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="113" mass="12668" checksum="4159722C7A947D99" modified="2018-12-05" version="1">MKKNKALAEMAELLKLLGDTSRLAILALLQVRELCVGEMVQMLEISPSNASQHLRKLRTAGLVREDKRGQWVYYSLNLDEFPDLKVFLSQLPGRQEIEEAMTLSLTEGGGIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR68</accession>
    <name>A0A398CR68_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heptaprenyl diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_03935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04650">
        <property type="protein sequence ID" value="RIE04650"/>
        <property type="gene ID" value="D3H35_03935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="324" mass="36088" checksum="C121EC251D331308" modified="2018-12-05" version="1">MKLMQLYASLKSDLQAIEDDMSRTVTSDMPTLSEASQHLMKAGGKRLRPVFVLLSGKFGRYSLDTVKKVAVPLELIHMATLVHDDVIDDAETRRGQLTVKSKWDNRIAMYTGDFIYAKALTVVSELGNPRIHQVLSNAIVQMCIGEMEQVRDFFETDQSIRNYLLRIRRKTALLIAISCQLGALATDAPKRHSDALYRFGYNVGMAFQITDDLLDICGTEKAIGKPPGSDLRQGNITLPVLYALQDPALKDRLLAEIRLIRQSEGAADSSAAVRIVRESRGIKDSEKMADRYIAKAVKALGELPDLTAKKNLAEIARFVAKRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRA5</accession>
    <name>A0A398CRA5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05073">
        <property type="protein sequence ID" value="RIE05073"/>
        <property type="gene ID" value="D3H35_02780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="61"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="306" mass="33655" checksum="7837DBE8BF77EF55" modified="2018-12-05" version="1">MQSSLKLGIVGLDTSHVTAFAELLNDPGHPYHIPGGNIRAAYPGVASPDFELSYARLQPYTDELANKFGVTLLDSEEAVAESCDAILLESVDGRVHLDQFRKLAPFGKPVFVDKPFALSTQEAREMIALAERYRVPLMSCSSLRYAEALSEQLRRMGGDPIAGADCYGPMAIQATQPGLFWYGIHMVEMLYRVMGAGCVRVAAETNADYDLVVGTWADGRIGTIRGNRKGNNKFGVLVHGEAAAYYADISSHSKPFYASMLEQVMRLFHTGEADIDLGETLEIIHFIECANESRETGRSVELRLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRA9</accession>
    <name>A0A398CRA9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_09605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03799">
        <property type="protein sequence ID" value="RIE03799"/>
        <property type="gene ID" value="D3H35_09605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="177"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="371" mass="41121" checksum="A0925AD85C4BCF24" modified="2018-12-05" version="1">MELERIVIVNHVAQLGGAERVLMNWLEKLDQKRVKAELVLLEDGPLADQAEQLGFGVHILPPGRIRNPGHYRRTVASIREIIRKSGAKLVVSWSPKPHMYGGAAAWLEKIPAVWWQHGVPSGNFFDRLVGYLPSHSIICPSAVVSEAQQKLSPRKRVVVQHPGIPMAEFLLDPQVRSEVRKEFGISESATVFAFIGRLQRWKRAEIVIQAFRDALKGKDACLFIIGGALFGVEEELESELKQLVREAGLESQVIFTGHQSRIAPYLWASDAVVHTSLFEPFGMVLLEAMASGRIVLAVNRGGPAEIIEDGVDGILYDGSVRQLTILMEQIGEEKRNFEKLGAAAIVTVREKFASGVMTERFGRLLSAAIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRF2</accession>
    <name>A0A398CRF2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02407">
        <property type="protein sequence ID" value="RIE02407"/>
        <property type="gene ID" value="D3H35_17005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017335280" evidence="1">
        <location>
            <begin position="35"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="442" mass="49759" checksum="C5B63483561583E1" modified="2018-12-05" version="1">MGGNKMKKLLVFGLILALTAVLFGCSNSNGNNTAKNEGRIDNTESSKPVKLQLSIWGDDNKKKFIEGVIKKFTDSHPNIQVEVLLIPFSDYQQKISIMTASKTAPDIIALFDRAIPQFIKADELMDISSLKNDSEYDYADLFSTSLEIYSRGDQLYGIPYTNPPTVLFYNKTLFEEKGMKTPLELYAEGKWTYDEFYKTAKALTDPKKGIYGARLMTPDWKNWSGSLMGLLWSYGADIFNEDGTKFVLNSKEGEQAIQLFYDLIFKDNVHIKPGDQLSFETGKIAMSNQDYNYVNNAMNIKDFEWDIAPKPTGPQADAPTPVGLGGYSVWKNTQHPEEALEFIKFLTSKEASQLQTNLFMPNRKSVLMSDEFLNGRSMPSAAGIQAALIDKMDSGVRVLGSHENWQQIDVKIQTVLDLLYTQNKTVKEVLELMEKEVAPLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRF8</accession>
    <name>A0A398CRF8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_03070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05122">
        <property type="protein sequence ID" value="RIE05122"/>
        <property type="gene ID" value="D3H35_03070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="161" mass="19280" checksum="17A24B1134CB78E1" modified="2018-12-05" version="1">MICFKYSRPYFLIEDSILPFRTELYFEIFNCFLDEDEILLFAGPVKTTDREYLKYIEERKVLTGSIDTWSWWPKSRKEIIWFRPNTKLEILKEIRVFCSCFVTETKNKNIINFSYALTLEETDEGICLYISEKQSGSFLSEVFPKIKKVLKDDKILYESLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRP3</accession>
    <name>A0A398CRP3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_05075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04840">
        <property type="protein sequence ID" value="RIE04840"/>
        <property type="gene ID" value="D3H35_05075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="210"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="313"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="572" mass="65040" checksum="46E23B0ED58AC9C6" modified="2018-12-05" version="1">MDNMCIVFGCEQMDFFDKISVIIILNRLYQRCLHLKRRDAPLLNTTFRTFHRVPISLKSHRYSPGSRLKPAMLRSASLLYVTGGRGRLLVDGNAHSLRPDLCVKLGAPATIELEADDKSELCIDFVQYRTMSIQCDGERLQAAWLEREADGFAAPLRSPSHMTALLSKLRTAMKDRSQEPSDRKQAVLCEMLDWVNEHEESRDAVSESLQRTIDYMNDHFAESIPLAALAGMAGLTPSSYCRAFKQAMGMTPGTYLTQIRLDLAKTMLAEPRSKLKEVAEWIGFQDELYFSRLFKKWEGIPPTVYMKKYEKKIAVVSGHLLQDHLLSLGVKPSAASGFPTFYRNASGFPSYLQDRLAATMPINSEKTVSSRDILRLSPDLILKTEFPDNPNDVEWLGANNTVIIDAHNSWDRYLMDVAVSIGKEPEAEKVVRDVKKTEKWGRKRLESIAKDGKWTIVRLLAGDCRMYGRSGHALSDLFYRDLGFRPDDGLEFVSYAGNALERLAALDPSNLLLIWSEPADIASFSEQPLWQRLKAVREKKVFCPDSKQWDPWGPIGRQYMIREMTKYFRSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRW7</accession>
    <name>A0A398CRW7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_17760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02537">
        <property type="protein sequence ID" value="RIE02537"/>
        <property type="gene ID" value="D3H35_17760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="452"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="558" mass="62430" checksum="E55F798DF28F0B54" modified="2018-12-05" version="1">MYKLLLVDDEADVREGVLREIEWEANGFEIVDVAENGREALEMTEIWEPDVVVTDIRMPFMDGLQLSERLRASYPATKIIILTGFDEFEYARKAIHLQVEEFVLKPFSAGELLQSLHKVKLRLDAEMAERENIDTLQGHYRRSLPLLREIFLGTLVTRNLSERDIAEKTDHYGLVLQGSHYTVSVLHLDKANNAASGNASSGAEPSAGRSLRESPDFELQSFAVRNIAEEIVDRVQAGCVFQHNDRVVVLGVSSENDGNLVRSQALSLLEEIRQSVEKFLKLSVTIGIGAATAKLTELKYVYDDAIAALDYRLLLGNNRVISIEDVETRHSAPVRYDELQEQSLLRCLKVGNAAEMEAIVEQLFAPYISAVQPISILDAQVFLLQLATTMLKAAQDTDNGAGGPFDGGMNPLKELTQFGSLLEARAWVVSTCAAMMGRIAIVRQTAYRSLVEEARQYTKANYSDSEINIAKVCAHLHISSGYFSSIFKKETKMTYMGYLLHIRMETAKELLLSTDLKTFEIAEKVGYSDPNYFSFSFKKHVGQSPKEYRSRAEGESAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS23</accession>
    <name>A0A398CS23_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4280 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02597">
        <property type="protein sequence ID" value="RIE02597"/>
        <property type="gene ID" value="D3H35_18105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025460">
        <property type="entry name" value="DUF4280"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14107">
        <property type="entry name" value="DUF4280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="128" mass="13076" checksum="77D316369C25741C" modified="2018-12-05" version="1">MGQLVCGGASLQCSFGVAPSTLMVLPVNRVMTSLPIANIMDNKPLVNILPFGMCNSMANPTVAAATAAALGVLTPMPCVPVTAAPWVPGSPTVLVGNMPALNNQSKCMCNWGGAIQIVNPGQMTIQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS30</accession>
    <name>A0A398CS30_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplN</name>
        <name evidence="8" type="ORF">D3H35_02290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05000">
        <property type="protein sequence ID" value="RIE05000"/>
        <property type="gene ID" value="D3H35_02290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 5 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE05000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="122" mass="13296" checksum="1139F136B278C9AA" modified="2018-12-05" version="1">MIQPFTRLAVADNSGAKELMCIRVLGGTGRRVGHIGDLIVASVKQATPGGVVKKGDVVKCVIVRTKFSTRRKDGSYIAFDENAAVIVKEDKSPRGTRIFGPVARELRERDFMKIISLAPEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSD8</accession>
    <name>A0A398CSD8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Xylulose kinase</fullName>
            <shortName evidence="3 5">Xylulokinase</shortName>
            <ecNumber evidence="3 5">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5 8" type="primary">xylB</name>
        <name evidence="8" type="ORF">D3H35_16335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02291">
        <property type="protein sequence ID" value="RIE02291"/>
        <property type="gene ID" value="D3H35_16335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005998">
        <property type="term" value="P:xylulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02220">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006000">
        <property type="entry name" value="Xylulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01312">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 3 5" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="FGGY_N" evidence="6">
        <location>
            <begin position="3"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="7">
        <location>
            <begin position="256"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="81"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="site" description="Important for activity" evidence="3">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="498" mass="53583" checksum="34A6C6EF7C98CD01" modified="2018-12-05" version="1">MKYVIGVDLGTSAVKTLLVGQDGSVKAEATREYPLYHDKTGWSEQEPEDWVTGTVESLKELTAKAGVGAEDIEGISFSGQMHGLVLLDENNRPVRRAILWNDTRTTEQCREIEKALGSKLLSVTRNPALEGFTLPKILWVRQYEPQTFEKARVFVLPKDYVRLRLTGNTHMDLSDAAGTLLLDIASKSWSKDVLSAFDLPESFCPPLVEASGYVGTLTVEAAESTGLSGETKVYAGGADNACGAIGAGILSPGVTLCSVGTSGVILTYEVDASADYKGKVHFFNHGKPDGFYAMGVTLGAGYSLSWFRNTFAKGESYDVLLGGIGEIAPGSNGLLFTPYLVGERTPHADSVIRGSFIGMDGSHTRSHFARAVLEGITFSLNESVDLFRKAGKTVDKIVSIGGGAKNPAWLQMQADIFNAEVVALENEQGPGLGAAMLAAFGCGWFPSLEACADKFVKPARSFKPDPEAAERYAVLFRVYQDVYGATKPLNEALLAYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSL6</accession>
    <name>A0A398CSL6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_19370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02797">
        <property type="protein sequence ID" value="RIE02797"/>
        <property type="gene ID" value="D3H35_19370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03497">
        <property type="entry name" value="SQR_TypeB_1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011138">
        <property type="entry name" value="Cytochrome_b-558"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016002">
        <property type="entry name" value="Succ_DH_cyt_b558_Firmicute"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000170">
        <property type="entry name" value="Succ_dh_cyt_b558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02046">
        <property type="entry name" value="sdhC_b558_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="223" mass="25322" checksum="06010AC8F83EBFCC" modified="2018-12-05" version="1">MSGNSFFARKLHSLLGVIPLGLFFVEHALTNYSAYEHGKDGFVDSVNKLHEMPLIFFLEMFIIWLPILFHGVYGLYLAFTSNLNVGRFNYGRNWAFALQRITGIITFIFVFWHVWQTRVQVTLGNTTYDQLGEHMHDIVNQPVYFAIYFIAVLAAVFHFSNGLWAFLVSWGITVGPRAQRISSNICMGIFVIVATLFILSLFAFRSDEFASAAELAVRSVTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT47</accession>
    <name>A0A398CT47_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-entry nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04429">
        <property type="protein sequence ID" value="RIE04429"/>
        <property type="gene ID" value="D3H35_07545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029476">
        <property type="entry name" value="DNase_NucA_NucB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14040">
        <property type="entry name" value="DNase_NucA_NucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="151" mass="17206" checksum="5EB0EC0268B77E72" modified="2018-12-05" version="1">MKKRRSRKKDKIPFFIIVIIAVAFFLNYYMEKEQPKTQPATSSNVVALFFPTDQYPETGRHIKEAIAAGESAICTIDRDEAEERRKESLKGIPTKKGYDRDEWPMAMCAEGGSGADIKYIDPSDNRGAGSWVSNQLEDYPDGTRVEFVFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTA9</accession>
    <name>A0A398CTA9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03067">
        <property type="protein sequence ID" value="RIE03067"/>
        <property type="gene ID" value="D3H35_21010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="104" mass="12919" checksum="59443E2DC26401C8" modified="2018-12-05" version="1">MDEVPYNLREVAEQRQQWDEVPYNLREVAEQCQQWNEVPYIRRKLRNAAEQWDEVPYNRQKLRNSAEQWDEVPYIRRKLRNAAEQWDEVPYNRRKVSEQRRTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTV4</accession>
    <name>A0A398CTV4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02741">
        <property type="protein sequence ID" value="RIE02741"/>
        <property type="gene ID" value="D3H35_19040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="81" mass="9096" checksum="BA40B752B6A18AC1" modified="2018-12-05" version="1">MIPFRNSLPYDIVMKDVYVPQCPFCEKSHVLLPLKPADIASIKGGAKKLGVVFPCCHTRMQLVDADNDYLLADRPIRTSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU65</accession>
    <name>A0A398CU65_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_06370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04238">
        <property type="protein sequence ID" value="RIE04238"/>
        <property type="gene ID" value="D3H35_06370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="83" mass="8919" checksum="9C58334D47C1C0A8" modified="2018-12-05" version="1">MTETLTVRLESLLSPVEKISFVFDKLNGIVSPLVCIGVGTTSNRVSLLYGASMPLKPAVEFCNANRTVDLLEGQVFGAMTEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU87</accession>
    <name>A0A398CU87_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02544">
        <property type="protein sequence ID" value="RIE02544"/>
        <property type="gene ID" value="D3H35_17800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="SSF50985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="653"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="748"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="834"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="918"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1361" mass="143626" checksum="F2CB18572F0690E1" modified="2018-12-05" version="1">MIGQLTPVAVSTLNGVKEIAAGASHSFALMKDGTVKAWGYNYTGQLGLGHTSNVISPSTIPSLSGVKQLAAGSNHTLALMENGTVQGWGSNAIAQLGSIGFQVRPSAFDYIPPDGVRISSSITGAYERPLSVQLYLDNEAEAREQLSASLVNGAAAVTFQPIASSTLAKGVHKARVVIATKEQSLERTIAFTASGGTVAYPLEVTATNSSLTAKASGTEALGELDAAPYRFTIGSQSSGWVSPSSVVFNNAVVSAGLDIGGSGERTITRLSNGWWVVAGYTGSAATGVTFLVSKDQGQSWLPLCSLVDATITSAPAITAVGTKIIGIVRSGSTNVKAFSFDAAVQENTNLFSELFALETGTKTIGNLSVAADRDGNVHAAWTINTSGYYSIRYSVNTDGGWQTVQQVTAVSSSNSYSNLKIAIINNQPVIISEFNQSSRYAISKLVWDGSAWTKTDIVSVYTYPQQNYSVFVDGQTVHLAWAGADSAQTSKKNIRYIRSTDGGSTWTAPSKLTTGNTYNQDNPVIAMDTQGKLYIVYGGQDAASPTYVNLRLLASSDGGDTWTTTPAALTALTSGSVDQPVVIQDGRLSYGDGNPIVIYKSGPGNQTLIRGSLVSGNIYTVSGLLPDTKYNVQFEVKDSGGVIRKVTKEAYTLADKPTITQVGQSASFTISDTNALTTKYQITAGGKYWSSEGKWVNSPTSLTLSSKTVALTKLDTKKTYRIQVRAVNQEGVPTDWSNTIQLGTPIAPPAAPANVKTQPSSTSVTLTWSPVSEATDYEVEVDNQATLYATGRSLSYKHTGLTPNTLHQYRVRAIKSGTPGAWSKVVLVRTLQVAPVVPTTAAPVATAKTVTLSWSAVANAFAYEVEWDGQIIATGKQLTLRQTGLPVLSRHTYRVRALNAGGASPWSALQTVSTTNAVPAVPTGIAVTVSDKAVTIRWDASLDALTYDVEADGKPPLNLGESTTVSFTGLAPGSAHQYRIRAVNESGTGAWSAYQNVTTYNLSTPSGLIEQLSDTSIGLTWSAVAGATSYEVEADGTVAAAAAASYTHASLVPETTHTYRIRALSAAGSSAWSELGRFTTLPLKPAVPANLTATASKDKVILTWSPVSGIAGYDVELDGAVIVDNFTDASYVDTLLDPYSPHQYRIRARTEAVEGDWSAPVSIRTLPDKPKAPTGIAVTSAGQIVTLAWEADPTAVKYEVEVNGAVTDAGTKNTFKHRRIAAGSEHKYRIRTTNVAGTSAWSGLIINNTITAWLTKAGVVDMGLVGMDITDFSRYTLNVTYDPGAIEITDLSTLTAAKELTTGKIKGTQITVASFKPGEIVFTTDKVIQPDESWSGVINSIQMKAKVSGGSSITYSVIERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUJ5</accession>
    <name>A0A398CUJ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YheC/YheD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_03405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000019">
        <property type="protein sequence ID" value="RIE04939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04939">
        <property type="protein sequence ID" value="RIE04939"/>
        <property type="gene ID" value="D3H35_03405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026838">
        <property type="entry name" value="YheC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38437">
        <property type="entry name" value="PTHR38437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="184" mass="20614" checksum="AE5A6E9E61CA6B6B" modified="2018-12-05" version="1" fragment="single">MSLTICNVHFTQQPERIVWLSSPLAKQLKLNGRKSVNVKLGRDTVPATVRTINRAGNHVYMSAGLRRSVRIPMSGNVHLSSADTDEIKLGPLIGILTDSATKSPTSPFGTRTGFVKQLLYMGRKKAYFFAFTPRDINWQQETVHGWFLDSGGTWFRRVVPLPDVVYNRLPSRRAETGTTISALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVH9</accession>
    <name>A0A398CVH9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF364 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03221">
        <property type="protein sequence ID" value="RIE03221"/>
        <property type="gene ID" value="D3H35_20375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007161">
        <property type="entry name" value="DUF364"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04016">
        <property type="entry name" value="DUF364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF364" evidence="1">
        <location>
            <begin position="137"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="277" mass="30255" checksum="09082D15535B8FC4" modified="2018-12-05" version="1">MHSRYSVSELREAILEGKLGPKPEVLPVTGSSSIYQTTQFPSSKIKYHNHYLLLRVESYFGACSHTTDQLDWEAAAQLSGLSLDAVLRDERLPVQIAAMDAYLGVVYPHQKHCTQVVDIPAGTPIQKAKLRDALIADMADIKASQKVALIGVVNPLVEAIRQRGGTCLPCDLQLEETQWGDAVEKDMDRVLDRADSVICTAMTLSNGTFDRIVERVRVRGIPLTVYAQTGSAVIAQFRTKGVTSLIAEPFPFTQFSAGASQLYCYSSGKGKEAAHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVJ9</accession>
    <name>A0A398CVJ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000038">
        <property type="protein sequence ID" value="RIE03241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03241">
        <property type="protein sequence ID" value="RIE03241"/>
        <property type="gene ID" value="D3H35_12765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="258" mass="27695" checksum="5E368865F4371BCF" modified="2018-12-05" version="1">MRGNIMKFANKSVIVTGSTSGIGKEIAFAFASQGADIAIIGRNADKGKEAVDTIRGMGRHAVFIATDLTNEASVKKMADEAMRSLGRVDVLVNNAGHLVSGAVPDIRPEDWHKTWQTNVTSVYLACHYLLPHMLNNRSGAIVNIASETALKGYKNRAAYGAAKAAVISLTKSMAVDHSEAGIRVNCLCPGTVETEMFNHLLTHNLDPNRHKQAMLDRRLTPFLGTIGEVAKAVLFLADPDMNYMTGSVLTLDGGSSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVL8</accession>
    <name>A0A398CVL8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_11175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03261">
        <property type="protein sequence ID" value="RIE03261"/>
        <property type="gene ID" value="D3H35_11175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="309" mass="33243" checksum="134E9C15267C291B" modified="2018-12-05" version="1">MDMWMQMIVAAVASGTPLLFATLGGILIERSGIIQLGAEGLMLMGAVIACLTYLNTGSLTAAILVVIAVSVALGLLHAFVTVTLRANQIVSGLAMTLLGAGLSAYIGKPISGLPLPGSVPKWHMSWLEPVPVIGDIFAHLDVFTWASFALVAAMHIYIHRTSAGLHLRAIGDNPPTADVMGIPVQWLRYGYVIAGSALIGLAGADLLLVYTPAWTEGMTAGKGWIAVALVIFARWNPLRALFCAYFFGMLDSLGFRLQLIGSDVPTYFLKMIPYFVTIFVLMFLGWRNRGKLSGAPQSLGTPYLREQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWA8</accession>
    <name>A0A398CWA8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3990 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_05065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04838">
        <property type="protein sequence ID" value="RIE04838"/>
        <property type="gene ID" value="D3H35_05065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025051">
        <property type="entry name" value="DUF3990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13151">
        <property type="entry name" value="DUF3990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="202" mass="22973" checksum="88B5772C271C1500" modified="2018-12-05" version="1">MEIMTPQLLYHGTTDTVVAGFQSKLLNSKYWKPGRDFGEGFYTTISAAQARKWAHRSVDRSVEPAKPCVLTVELTSMPKKYEPRVFLSESPAWSQFIFDHRTIAIKGEDPCDKHPDIVIGPMADNDTGKIVLQAVQLKKDADWFYDQITRTGKGRRLDSLRLGNQVVFSSERWESSLRLVGYSIFAGGRWIYHENASQIESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWC0</accession>
    <name>A0A398CWC0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dipicolinate synthase subunit DpsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dpsA</name>
        <name evidence="3" type="ORF">D3H35_11655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03511">
        <property type="protein sequence ID" value="RIE03511"/>
        <property type="gene ID" value="D3H35_11655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014215">
        <property type="entry name" value="Dipicolinic_acid_synth_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031629">
        <property type="entry name" value="DpaA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16924">
        <property type="entry name" value="DpaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02853">
        <property type="entry name" value="spore_dpaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DpaA_N" evidence="2">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="1">
        <location>
            <begin position="153"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="299" mass="32257" checksum="E5D27A1FA5DA424F" modified="2018-12-05" version="1">MLTGVQVVLAGGDARQLEVVRRLTELDAAVTLVGFDTLETPFSGVVKAEWSPDILRDADALLLPAVGTDDDGSIQAVFSDQELKLTEAHLSVMPKTCALYAGMAKPYLRKLCEKHHLKLVELFERDDVAIYNSIPTAEGALMMAIQNTDITIHSSSCIVLGLGRTGLTMARTLQGLGAKVKAGVRREESFARAFEMGFEPFYIPDLARHAGNIDLLFNTIPTMIVTAQVIAELPLRAVIIDLASKPGGTDFRFAEKRGIKALLAPGLPGIVAPKTAGRIIANSLTQIILEDKRQRGNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWC4</accession>
    <name>A0A398CWC4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04858">
        <property type="protein sequence ID" value="RIE04858"/>
        <property type="gene ID" value="D3H35_05180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="86" mass="9896" checksum="955F1F126B511640" modified="2018-12-05" version="1">MSAVGYATIWAILLLFPALAAWRRKWWPVALYVIGLLIFLYSVLQDNTGWDDLADFAMLIIVVAPLYVIATVVWVLQLIWRKTRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX46</accession>
    <name>A0A398CX46_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PA14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03781">
        <property type="protein sequence ID" value="RIE03781"/>
        <property type="gene ID" value="D3H35_09515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="1">
        <location>
            <begin position="755"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="957" mass="107075" checksum="002295D1DD5B3FCB" modified="2018-12-05" version="1">MEFRFLRPKWVISTVAVALISLLLWLFASWDPIPGQSDYTASASSVPVQGELNRSYVDWKQQQIPFGVSSFDLAPWRSYMDTWDASRYLETLGVVFNVSDNEADATAQLLSEAGVRSARVEIGWGNISFDNEAKLKEPQIKGFEKIIAALKKHGIRPIILLNANSGNPVPNKFVDIKVKKFAAKGSRQIYVEKTAGIVPNYTGLIGQAYQTMFPIITSVDSKTGLLKLSAPLANDVKAGTLRIVQMKYRPFAGTVFSDGKSNPSATETINGWKKYLQTLTTFLKQSLGTTSSPSDAGFDLEVWNEMTFGSQFLDINNYYNPKLSFSKLPSYTLGGRTQEGPELLLPLTIDFVNNRDNKLPGVRVISGFSNQRPWENGTEMFAGQTGFSRHYYTGYNGEASIIKSDKNTATKKFMSATGNVTEGSSSYIPEHIEAMPEHWFYAYHTEFVVRDIQPYPGPWSQHYRYANPGNGKQAEVWMTETNWWRWPFAQKVVLAAKVSETDPRLISLMQNIGAKATLRTFTFYSHKGVKTVDMYAAKSGDLSHGVFSDAFFKELAANNYRLTDSARRLAGPQIQTLIRTAKLMRMGNKIENPRPIEVTKLVELNERIALKGNGTEEHPNTYNRDDFAILPFQLTENKFAIGYYVVTRDLTKEWQKDRSLLDPQRYAMPAQKFEITLSNIDGNRASVYSYDPLTDKRIQMGISAKTDTTLTVEVESVDYPRFLIVEESRSIAGPILSDVKLEQEGQNTFLSFRSNTAGNATVSWGPYPARSGGSFQLDLYADTQAVTPLKTYQTNLIQTDLAPSLTKGAWKWTGTIVPKYSETYSFALDTNICKAILKIDGQTVINGCASPIKAGTIDLIAGQTYSLELAFINDHENPQYSTLYWASQSQAKEPVTADPKGQRTASVAMDGVNRARIPLPGFERGHGVKIDFASSEGNLQTRFPQWNYDVRGVWWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXV3</accession>
    <name>A0A398CXV3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 5">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rfbA</name>
        <name evidence="7" type="ORF">D3H35_09735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 5"/>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03824">
        <property type="protein sequence ID" value="RIE03824"/>
        <property type="gene ID" value="D3H35_09735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="299" mass="33005" checksum="BF55A4F6311D5126" modified="2018-12-05" version="1">MKGIVLAGGSGTRLYPLTKSVSKQLLPIYDKPMIYYPLSVLMLAGIRDILIISTPSDTPLFQHLLGDGSAWGLNVTYAVQPSPDGIAQAFRIGETFIGGDSVALILGDNLFYGHGLTELLHKASARERGATVFGYSVKDPERFGVVDFDESGRVLSIEEKPRRPASPFAVTGLYFYDNRVVEIAESIAPSARGELEITDVNKVYLELGELHVELLGRGYTWLDSGTHESLLEASQFIETIEKRQSLKIACLEEIAYTCGYISAEDVLTLAQPMAKNEYGQYLLNLINRNRNRKFAKAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY81</accession>
    <name>A0A398CY81_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YfhD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04181">
        <property type="protein sequence ID" value="RIE04181"/>
        <property type="gene ID" value="D3H35_06055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025435">
        <property type="entry name" value="YfhD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14151">
        <property type="entry name" value="YfhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="55" mass="6156" checksum="D3B7E4FEDB839322" modified="2018-12-05" version="1">MTNHSNSHLETEEQEKDGLAEDVEFSEELADADDLEAQQRANDADDRAAEYEGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ80</accession>
    <name>A0A398CZ80_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="3">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">typA</name>
        <name evidence="3" type="synonym">bipA</name>
        <name evidence="5" type="ORF">D3H35_06350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04234">
        <property type="protein sequence ID" value="RIE04234"/>
        <property type="gene ID" value="D3H35_06350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="5"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="613" mass="68552" checksum="923B0EA84234C227" modified="2018-12-05" version="1">MQPRDHIRNIAIIAHVDHGKTTLVDQLLRQSGTFRDNEQVQERAMDSNDLERERGITILAKNTAVNYKDYLINIVDTPGHADFGGEVERIMKMVDGVLLVVDAFEGCMPQTKFVLRKALEAGLTPVVVVNKVDRPAARPLEVIDEVLELFIELEANDAQLEFPVVYASGLNGIAGMSPDAIGDTMEDLYETILKHIPSPTENPDEPLQFLVTLLDYNEYLGRIPIGRVNRGRIRQGQPVAVIDREGKIRQARIEKLFGFQGLKRVEMEEAAAGDIIAIAGLKDINIGETVADLANPEALPVLKIDEPTLQMNFMVNNSPFAGREGKFVTSRKLRERLFKELETDVSLRVDETDSPDSFVVSGRGELHLGILIENMRREGYELQVSKPEVILKEIDGVKSEPIEHLLIDVPEESMGNVMESLGARKAEMTNMVNNGSGQVRLEFLIPARGLIGYRTNFLTLTRGYGVMNHTFHSYGPITPGQVGGRHQGVLIASETGKSTMYGMMSVEDRGILFLEPGADIYEGMIVGEHTRDTDIIVNICKEKALNNIRTANKEETVKLKSARLMSLEEALEYLNDDELCEITPKTFRLRKKVLNKSERDRYEKQRKMAESGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0E2</accession>
    <name>A0A398D0E2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04634">
        <property type="protein sequence ID" value="RIE04634"/>
        <property type="gene ID" value="D3H35_03840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="117" mass="12648" checksum="B38595C19169C304" modified="2018-12-05" version="1">MSALVTVTFLPDGRSIQVRPGTTLLDASRRARVSIRTRCGGVAGCLMCKVTVAAEYESSLNAPPAPEARKLDTLLDEGVRLSCQARVKANVVVTVPEDPLKAAIRKKLAEQQAEEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0L3</accession>
    <name>A0A398D0L3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05031">
        <property type="protein sequence ID" value="RIE05031"/>
        <property type="gene ID" value="D3H35_02525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="191"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="396" mass="42877" checksum="A4D1172EF98E1669" modified="2018-12-05" version="1">MTTANARLRGGTDDLKEQLVAWRRHLHRHPELSFQEHNTADFVEERLRGFGGLEIKRLTPTSVIARLIGAYPGKTLALRADMDALPIQEENGHEFVSQAPGVMHACGHDGHTSMLLAAAKLLAARKDKLHGEIRFIFQHAEELPPGGARELVEAGAVDGVDWILGEHLSSLLPLGQIGLGYGATAASPDNFSIVIKGSGGHAGSPHRSVDSIAIGAQVVTNLQHIVSRNTDPLERLVVSVTQFTAGASNNVIPDTALLRGTVRCFDDNLRREVSRQIERLVAGITSAHGASYEIDYLFGYDPVVNDDKLTRIIEEVAGEVAGAGQVSILPPGMGAEDFSAYQRKVPGTFVMIGAGNPSRGIIHPHHHPKFDFDEDALPIGTELFLQVAERLLEWEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1M0</accession>
    <name>A0A398D1M0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DegT/DnrJ/EryC1/StrS family aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_02785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05074">
        <property type="protein sequence ID" value="RIE05074"/>
        <property type="gene ID" value="D3H35_02785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="414" mass="45315" checksum="F17DBC90096C20F9" modified="2018-12-05" version="1">MSEQLAIHGGAKVKSIPFGTGRRFGEEELQELREALEQDTLFYHYGAKVKRFLQKFNEMYGVKYSVATSSGTAAIHVALGAAGVTAGDEVITSPITDQGTVVGILYQNAIPVFADVLPDTYNLDPASVEARITKRTKAIVAVHLAGNPCDMDAIMAIARKHNLKVIEDCAQSYLSEYKGKLVGTIGDYGCFSTNDFKHISTGDGGMVTINSGDEEDYTIAHAFADKNYQRFDTKVNRDIHHLAPNYRMTELQGAVGIAQLDKLAWICDKRKEYGATLTAGLAGIPGILPPAITEGSASSYWFYLFRLDTSLLNATVDEFVAALNAEGIPSIRGYIPQPVYLQPMFQKKEAYPGTNYPFSLSDVSYDQGICPNAEAILQTSVRMGISEFYTADDIRDMVAAIRKVAAYYRMPGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CAN3</accession>
    <name>A0A398CAN3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00196">
        <property type="protein sequence ID" value="RIE00196"/>
        <property type="gene ID" value="D3H35_29605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="181" mass="20512" checksum="40A4E7CDFB0C2614" modified="2018-12-05" version="1">MPFEFRISNFEMDHEAYMDFLIRHHDELNLPYPFAMKLSFISSPLFLGKAMLVIDEVSYRMVGAAGFGYGTGPGDYEDRHICQVEVAFIEEHLRCTSLFAQGLRALVDAIQSDNPDVRQVQFWASATEERLNRLFAKFLALPGSTRSTVNGLALFTVPLHELEAYCSRLRRSVIAGNNEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBR2</accession>
    <name>A0A398CBR2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00596">
        <property type="protein sequence ID" value="RIE00596"/>
        <property type="gene ID" value="D3H35_27875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="106" mass="12758" checksum="1CB504C64A2BFDF2" modified="2018-12-05" version="1">MALQFRRSDRLGIELPLFSQDWEEMSRERQARILTKWETIRGTIPDHVKRFEERIKALQERLFNEDDFEASCRVNGDIADLASRINDLHIWFRTQQDLDEDAKRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCM2</accession>
    <name>A0A398CCM2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000055">
        <property type="protein sequence ID" value="RIE00470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00470">
        <property type="protein sequence ID" value="RIE00470"/>
        <property type="gene ID" value="D3H35_28215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="3"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="210" mass="23864" checksum="D705A7A7CA4AD930" modified="2018-12-05" version="1">MRQIAEFIRAFDLGQAPLLRVGLLELEPERQVLLYDMHHIISDGVSMDILVREFVGLYGGQTLPAPRLQYKDYAVWQQAFMQSEAMKRQETYWLETFSGELPVLEMPTDYPRPAVQSFKGDQIQFELDGELSAGLNRIAAETGTTLYMVLLAGYSVLLSKYTGQEDIVVGTPIAGRPHADVENIIGMFVNTLAMRRGRQGRKHLRRICRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCR2</accession>
    <name>A0A398CCR2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_25515</name>
        <name evidence="5" type="ORF">D3H35_28175</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000054">
        <property type="protein sequence ID" value="RIE00493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00493">
        <property type="protein sequence ID" value="RIE00493"/>
        <property type="gene ID" value="D3H35_28175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00929">
        <property type="protein sequence ID" value="RIE00929"/>
        <property type="gene ID" value="D3H35_25515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="131" mass="15689" checksum="FA63F7609534E0A6" modified="2018-12-05" version="1">MEKYLSRKSYITVFLLPALVVYVFTVLLPIGWSAVYSFYEWDGISPMKFTGFDNYIRMFTEDDVFWQVFKNNIVFTIVNVVFQVSVGLFIAVLLTKIKRAARFFRRSISRRWFFPRLRSFKSFRTSFPSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCX1</accession>
    <name>A0A398CCX1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="15">ATP-PRT</shortName>
            <shortName evidence="15">ATP-PRTase</shortName>
            <ecNumber evidence="6 15">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">hisG</name>
        <name evidence="17" type="ORF">D3H35_21480</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 15">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 15">Heteromultimer composed of HisG and HisZ subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Lacks the C-terminal regulatory region which is replaced by HisZ.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the ATP phosphoribosyltransferase family. Short subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="6 15"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01026">
        <property type="protein sequence ID" value="RIE01026"/>
        <property type="gene ID" value="D3H35_21480"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13595">
        <property type="entry name" value="PBP2_HisGs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01018">
        <property type="entry name" value="HisG_Short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024893">
        <property type="entry name" value="ATP_PRibTrfase_HisG_short"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13 15" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="16">
        <location>
            <begin position="56"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RIE01026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="212" mass="23788" checksum="925B8D9830BDC64A" modified="2018-12-05" version="1">MTDNGILKVAMPKGRIYKQASKLFRQAGLPIPEDFDDSRKLIIPVPEANMEFIMAKPVDVPTYVEYGVADIGIVGKDVLMEETKDVYELFDLGIARCRMSVIGLPDWKPVIHPRVATKYPNVASQYFRERGQQVEVIKLNGSIELAPLIGLADRIVDMVETGQTLRENGLVEMEEMFQVTSRLIANRVSYRLKNTAIQALCDRLGQSMTVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDX2</accession>
    <name>A0A398CDX2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_27100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00635">
        <property type="protein sequence ID" value="RIE00635"/>
        <property type="gene ID" value="D3H35_27100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="5"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="271" mass="29954" checksum="80D00D428BFFC386" modified="2018-12-05" version="1">MKSTIRLDKMLGNLGYGTRSGIKSLVRQGAVSVNGLMAKDPGMQIDPQADTVVLDGETIRYRDTVYVMLHKPAGVVSATEDKRDRTVLDLIDDEDITVFVPFPVGRLDKDTEGLLLLTNDGKLSHELLSPRKHVPKTYRALVAGQVAEADVKAFAKGVTLDDEYVTLPAQLSVLEVVAGGAEPTQPSMIYAFSRAADIPEDAANLSWIELVIHEGKFHQVKRMFEAVGKKVLYLRRESMGPLHLDESLAPGQWRELAEDELESLRNFRKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEN7</accession>
    <name>A0A398CEN7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF418 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_21960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01090">
        <property type="protein sequence ID" value="RIE01090"/>
        <property type="gene ID" value="D3H35_21960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007349">
        <property type="entry name" value="DUF418"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04235">
        <property type="entry name" value="DUF418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="DUF418" evidence="2">
        <location>
            <begin position="234"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="407" mass="44829" checksum="9B17CEB30F49F726" modified="2018-12-05" version="1">MTSIDEQGNRVGAVDKIRGLCLLGILMANMVIFQYGFYGMEAGSAFHLSRIDEWAHRGLQIVVDGNFIPIFMFLFGYGVYKLRRGLVQRGLKPGWVLVRRFVMLIVFGIAHSFALWEGDILMGYGTMGFALLLFANRKPKTLIIWTLLLSLVLIAAGYGTGDSKSEKEEKQRIEEYVERSIEVYQHGSYAEIFDFRLSDDPDIPDLPGNGAVLAAVVIIAMLPMFLLGIIAAGKRWFHDPGRERRRYIGSASVLLPIGLGLKSWAVLHLSSAWSGVWLTAGAGMLALGYIALAALLFSIVPDRNVVARAFQAVGKMSLTNYLMQSVICTTLFYGYGFGWFGKLGVLSGVLLAAGIYSVQAAASLLLLSRFKIGPMERVLRMVTYWSLSGRPRTRKVPVPDPIGANVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF40</accession>
    <name>A0A398CF40_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01190">
        <property type="protein sequence ID" value="RIE01190"/>
        <property type="gene ID" value="D3H35_22595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="146" mass="16272" checksum="4B56641379E0692B" modified="2018-12-05" version="1">MHERMTRVTRHSWAINPAREQMAGVTGYSWAISPAREQMARVTGYSWAISPAREQMARVTGYSWAIGLAREQMARVTGYSWAIGPARERMAGVTGYSWAIGLAREQMAGVTGYSWAIGPAREQMAGVTRHSWAIGPARERKNDRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFB6</accession>
    <name>A0A398CFB6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">M67 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_28010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00582">
        <property type="protein sequence ID" value="RIE00582"/>
        <property type="gene ID" value="D3H35_28010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prok-JAB" evidence="6">
        <location>
            <begin position="13"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="149" mass="16578" checksum="FE6713A3B4576D97" modified="2018-12-05" version="1">MNADTSKIILTSKLEKELLAACRSRLPYEACGIVLAAQSDTEGNEALMKPDSFAIVRNVSTNPERTFRFSPEEYVAAVYEAQKNQRRLVGFFHSHPTGEPLPSFEDGQGSLSWGTYWIVGLGKESGPEIAVYRRDEAGDWLPLSLERVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFC5</accession>
    <name>A0A398CFC5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Stage V sporulation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">spoVB</name>
        <name evidence="8" type="ORF">D3H35_27725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00592">
        <property type="protein sequence ID" value="RIE00592"/>
        <property type="gene ID" value="D3H35_27725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13124">
        <property type="entry name" value="MATE_SpoVB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024923">
        <property type="entry name" value="PG_synth_SpoVB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014249">
        <property type="entry name" value="Spore_V_B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038958">
        <property type="entry name" value="PG_synth_SpoVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02900">
        <property type="entry name" value="spore_V_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="362"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="520" mass="55690" checksum="982BD0F1037F3486" modified="2018-12-05" version="1">MRKQSFIQGAMILLAAGVLNRLLGFVPRIALPRMIGAEGVGLVQLVYPFTIVLLTIIAGGLPLAVAKLVAEANSRNDKDAIRPIVRTAMSLAIGLSLTAAAICIALADWISSRVMTDPRVHAAFLTMIPVLPLVGISSIWRGYFQGKQNMIPTALSQTVETIFRIVMTLIGAAALIPYGLEAAAAGAVVGMVTGELAGLFVLWIQIVRDRKPEKTNADPEAKTAAPRRANSYTRQLLRIAVPVTGSKLIGSLSYLLESILTARSLAAAGLTAAAATAQYGALQGMVIPLLLLPGALTYSLAVSLVPSLSEAAAREDWPTIHKRLHQSMRLAIVTGAPFVVLLGMLADPICTLLYGDDSMASMLRWLAPIAIFLYMQAPLQAALQALNRPGTALFNTFAGAAVKLALIVQLATDPKLGILGAVIAIAANMALVTVLHWFSIARLTGFRMQPFDFLKVTGAMTIMSAVALWIWNRNWLPGDGIELGTASLLSTLVYLLLLILFRLVDRHDVERIPLLGRLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFL5</accession>
    <name>A0A398CFL5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-siderophore ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00692">
        <property type="protein sequence ID" value="RIE00692"/>
        <property type="gene ID" value="D3H35_26180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="34" mass="3757" checksum="4045F9B7E66FF55F" modified="2018-12-05" version="1" fragment="single">NVEAIVALKPDLIVATKVRHEKIYAQLEAIARPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFR6</accession>
    <name>A0A398CFR6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_24760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01563">
        <property type="protein sequence ID" value="RIE01563"/>
        <property type="gene ID" value="D3H35_24760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="19"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="493" mass="57224" checksum="95FA08B333C9E875" modified="2018-12-05" version="1">MVQEVDYKRKWWKESVVYQIYPRSFMDTNGDGIGDLKGIISKLDYLHNLGVDVIWICPFYKTPNADNGYDISDYYAVSEEFGTMADFEQLLSEAHRKGIKVIADLVLNHTSDEHPWFVESRESKDSPKRDFYIWKKAKENKEPPSNWASFFGGSAWEYDEQSAEYYLHLFTQKQPDLNWENPLLIEELHRMVRWWLDKGLDGFRIDAINHIVKMENYPDAEAPAHEKIVSAHHLCSNLPKVHDHIQNLNREVFSHYDIMTVGEAANTGPEEALLYVDENRAELNMVIHFEHLGMDSSNGGLESWEKTPWSIDDYRDVVTHQFYRQAQKEGWTEDRIMRAIHQSSRDNARTPMQWNDQAHGGFTTGTPWVQANPNARWINVESAVKDPNSILNYYKKLISLRKEHLVAVYGKYESIFLENTSILAFSRTLRNEQLVVVMNFSAASAHVEIPEVSADKSIKLLLSNVESDLVETRVDDRLQPYEARIYLRGVIPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG45</accession>
    <name>A0A398CG45_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_15710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02186">
        <property type="protein sequence ID" value="RIE02186"/>
        <property type="gene ID" value="D3H35_15710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="102"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="304" mass="33502" checksum="A9BFA48D9A4AF8CD" modified="2018-12-05" version="1">MGKISKDLFAPADPSNGGDVIVRPSLNYWQDAWRRLRRNKLAMIGLVVLIVLTVLAVAAPWLSGYDYETQNLSEINLKPSGGHFFGTDDFGRDLWVRVWWGTRISLFIGIIAALLDLVVGVIYGGISGYFGGKLDTVMQRFIEIVSAIPYMLIAILLIVLLGPGVDSIILAYAITGWVTMARLVRGQVLLLKQQEYVLAARTLGASPVRIIARHLIPNVIGIIIVQITFVVPSAIFVEAFLSFTGLGIKPPLASLGNLLNDGAQYMRYQPHRLIFPTIVFSLILLSFNLLGDGLRDALDPKMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG56</accession>
    <name>A0A398CG56_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_25530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00932">
        <property type="protein sequence ID" value="RIE00932"/>
        <property type="gene ID" value="D3H35_25530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="204" mass="23393" checksum="7973B738EE886595" modified="2018-12-05" version="1">MNKSSLRESKKEATAHALAEAAFQLALERGMDGFVVEDVVQRSGYSRRTFANYFSCKEEAVATATVPYHDVGEFYELLNRMSDSTSPIDALYQFVKMQLAEETIRRLRQLFTLSESYPNLKPYTLTAVQRLQRETQELMAELFRETHPRDYNYLLVGSVFSMIVPMFDGTFRVLLLGESADDASGTQSFDNYFETIFGYLRNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGH0</accession>
    <name>A0A398CGH0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_24710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01555">
        <property type="protein sequence ID" value="RIE01555"/>
        <property type="gene ID" value="D3H35_24710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="479" mass="56990" checksum="66C9F1CDDFDC5DBD" modified="2018-12-05" version="1">MYTLNDIFLGKNDGKKEASYRPDFENYFYDHNKIYHKVMQNEKYLVLGRKGTGKSILGEFIKKKAQNDAEWFCNLCSYKEFQFHELVNLKNGDIKPNEYISIWEWVILLELAKLCLENENLSYSETWQKLNKFVRDNFFTVKLNAMKIIEVTQQNKLSGNLFKFGGEHGKTKKYSVGSYLYYLDDLRETVFELLAETDCKYTLIYDELDDKFRNNEIYKNSIISLIKAVDKINLSMLDNRINGKVTVLLRTDIFYILNDPDLNKIKIDNSITIDWGATIQVDSPLFDLVFTKIKASVPDLKDKSRVELFTLFFPEQIRRIDTEKFLLGRTFFRPRDVVTYLNFIIEKYAQESRFKEHAFIELEKDYSTYFFQEVRNELSGHLDDLLIDEGTLLLKQYNRGEFKFKNLKEYYEKNKSIYPNIKLEEILKTFFEFGLIGNKWKKDGMDRYFYSWAYRDNKAVIDFDKEFAIHVGLRTELSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGL7</accession>
    <name>A0A398CGL7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_13965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01883">
        <property type="protein sequence ID" value="RIE01883"/>
        <property type="gene ID" value="D3H35_13965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="71"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="295" mass="33261" checksum="AAA38FF6BCBCA139" modified="2018-12-05" version="1">MVHSNTLRDKLSRWFITGLLTAAALLCLFPILNLIAISFSDKASTSANEVIFWPLGFNTNAYEIILKNHAFLHSLWIAVERVVAGVAVNMCLILLSAYPLAQEVKRFKSRTFFVWYYVFTILFSGGLVPLFIVVNKMNLYNNFWALILPYAVPAFSVIILMNFFRSLPAGLTEAAVMDGAGHWTILLRICLPLSLPALATLALFSFVQHWNDWFVGLYLMSDSVKWPLQTYLYSQLYVGIDFSRLSPDEAILIGSISDRSLRAAQILLTMVPILIVYPFIQRFFVAGLTIGSVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGX4</accession>
    <name>A0A398CGX4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Thiazole synthase</fullName>
            <ecNumber evidence="4 6">2.8.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thiG</name>
        <name evidence="8" type="ORF">D3H35_17305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:26297"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12909"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.8.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer. Forms heterodimers with either ThiH or ThiS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.10" evidence="4 6"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02456">
        <property type="protein sequence ID" value="RIE02456"/>
        <property type="gene ID" value="D3H35_17305"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990107">
        <property type="term" value="F:thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04728">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00443">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033983">
        <property type="entry name" value="Thiazole_synthase_ThiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008867">
        <property type="entry name" value="ThiG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34266">
        <property type="entry name" value="PTHR34266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05690">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiG" evidence="7">
        <location>
            <begin position="7"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="208"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DXP" evidence="6">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="258" mass="27661" checksum="CE76D9A44196DFBF" modified="2018-12-05" version="1">MPDFFRIGKHELSSRFFIGTGLFPNPYVQMEAIKASGAQVLTFAIRRINLEATEDDSILQHLQNESYIYLPNTSGASTADEAVRIARLARASGLSDWIKVEISANERTLLPDPIETLKATEVLVKEGFTVLPYISDDPVICKRLEEAGAAAVMPGAAPIGTGLGILNSYNLGLIVEEANVPIIVDAGLGSVSDVAQAMELGVSGVLMNTPVAKARDPVGMAQAMRMGIEAGRLAYLSGRIEKKRYASASSGFEAYKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH33</accession>
    <name>A0A398CH33_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_29735</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00218">
        <property type="protein sequence ID" value="RIE00218"/>
        <property type="gene ID" value="D3H35_29735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031621">
        <property type="entry name" value="HisKA_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16927">
        <property type="entry name" value="HisKA_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="5"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="363"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE00218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="597" mass="67780" checksum="3ED9C131024CE182" modified="2018-12-05" version="1">MSILLIFATALMLFISYLSYQKRHLPVARTVIFIMLAAAFYSLGYAIEILSVSLRGVKLALHIEYLGIPFVTVLWLVLVLQFTNIAAKYRRRLMLLLFAIPVATFFLHLTNDWHHFVYKEYVLNPDGVLPRYNTVKGFWYHVNGYYNYFVIAAGMVLFIPMYSRALPIVRKQILIIALGAVAPFAFNLIYQFARTSIDLTPFGFAVSGFACVWGILRINLLRLTPLALAKVFDTIRDGVVLLDYEDQIVSFNRAAEEVFPELAATKRYPAPGKRVLSNCPELLERIAAANGLDERFPFQRSGMNRHRHYICSLSFIYDIGMDPIGKIVMFNEITELMENEARLRENARQLSRLNAFKDKLFTVMAHDIRDPIALLVSLTELLGEEPSETDIEHAEVFQEIRRQVRNTYHLVDNLLDWYRSQNGKVAFRPLEWNLQQVVRQALSLAGARAGMKQILMTENIDDALTVSADKEMLDLILRNLLSNAIKFTGVGGRIEFGAVVEGDLVKVSVSDNGMGIDEETSELLRQEELFFKEPGSANERGEMRFGLLLTREFLRIHGGSLRFDSVPGEGTTFLFTLPGSANRGETAESYQTAVRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH63</accession>
    <name>A0A398CH63_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphatidylglycerol lysyltransferase</fullName>
            <ecNumber evidence="6">2.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lysylphosphatidylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mprF</name>
        <name evidence="7" type="ORF">D3H35_28895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:10668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:75792"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="EC" id="2.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the LPG synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.3" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00429">
        <property type="protein sequence ID" value="RIE00429"/>
        <property type="gene ID" value="D3H35_28895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050071">
        <property type="term" value="F:lysyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="318" mass="34964" checksum="3A48776D0BA08F1B" modified="2018-12-05" version="1">MRVKPFVVATAALLFLAFVLMSWQLFDHTAMQRQLRTLLDHPGWLLAMFAAYALSFVLKAEAWRAYEKREQRLAVYLHGIHYSLLVNHLLPVKLGDLARVGVLMKASRKKWDEALHSVAVMRLLDLLVLGTISSAGMLLLGLTVSWTAMIAAAVLILAAIVTVKLLPERKTAFLRKHARTVKAVALSRDGPYIVALTTLSWVLEAVILFGVIRLSGFHFGALSLVWANSMTVGGQVFHITPGGLGTYETTLSGTLSLLGASWENAYGAALLTHGIKFAAAFLLGGYSCVRMPIGLREAASWIRRQPGRTMRPDERTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH80</accession>
    <name>A0A398CH80_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetylglutamate kinase</fullName>
            <ecNumber evidence="7">2.7.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetyl-L-glutamate 5-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">NAG kinase</fullName>
            <shortName evidence="7">NAGK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">argB</name>
        <name evidence="9" type="ORF">D3H35_15195</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetylglutamate kinase family. ArgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02103">
        <property type="protein sequence ID" value="RIE02103"/>
        <property type="gene ID" value="D3H35_15195"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00082">
        <property type="entry name" value="ArgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="40"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="7"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="261" mass="27314" checksum="FE1757341AAD6865" modified="2018-12-05" version="1">MNRFVMKCGGSTLAALPDAFFQDLRELQESGIQPVIVHGGGPAINETLGKLGIESRFLNGLRVTDEATLDVVEMVLAGRINKEIVRKLQQNGAVSIGLSGTDGRLIEAQPVANADEVGLVGDVTGVNAELIEGIVALGYLPVIAPIGIDASGQRYNINADTAAGAVASYLGVDTMIVVTDVPGIMRTVNGEKVVLPQVTFADIEEMIASGEIYGGMIPKVRAAMSCLHGNVREVLIVDGSAPRVLSRAVREGGIGTRILRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH89</accession>
    <name>A0A398CH89_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anthranilate synthase component I family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_23445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01332">
        <property type="protein sequence ID" value="RIE01332"/>
        <property type="gene ID" value="D3H35_23445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="2">
        <location>
            <begin position="45"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="260"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="537" mass="61165" checksum="ACB01D9BA5802FA8" modified="2018-12-05" version="1">MEMITLEQWEQWIRDPEPFSLLPYVRRIEGAIPLFWDRFWEEASAYGCLFESGKGGRYTTAALRPVSVVHGKGRRAQSLERSAVQGVAERWDVVREWDAAPLEAVREWGREWRAPQLEERQKQELPDCLGGAFGFWSYDIVRSLERIPSTARDDLELPDYLFSRFEELWIADQATGFVYLSVHLHVNGASTLQRTSDLELAYREAARRAERMERQWRHWCDIGTDAEASSRHAEMRGLMEQDKLQIDVEAVPGLVTSMSKRAYEEAVRRIQHYIGQGDVFQVNLSLRQSCPSPTKPEQLYEWLRLVNPSPYMGMIRTPSFSLVSASPELLVKLEDGRLSTRPIAGTRRRGHTPEEDRAMELELLASEKERAEHVMLVDLERNDLGRVSAYGTVKVPELLTVERYSHVMHLVSQVEGRIAAGKDAFDVMAAVFPGGTITGAPKIRTMEIIEELEPLQRGAYTGSMGWIDYAGDMEFNIIIRTMVVKDGVCHIQAGAGIVIDSDPEREFHESLNKAKALWKAVQYGEKLPVCERKGEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH95</accession>
    <name>A0A398CH95_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01840">
        <property type="protein sequence ID" value="RIE01840"/>
        <property type="gene ID" value="D3H35_13705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="80"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="202" mass="22282" checksum="C925C0F5B21EF4FD" modified="2018-12-05" version="1">MIHIYRQGTDAKAPTLVFFHGTGGTERDLIPLAPILSPSSSVLSVRGNVLENGMPRFFRRLAEGVFDEEDLVFRTKELAEFLDHAAAEYGFDRGNVVAVGYSNGANIAGSLLLHYPDALRAAILFHPMVPRRGIALPDLTRTPIFIGAGRNDPICSPQETEELEGLLRNAGSSVSVHWENQGHRLTQSETEASAKWLREQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHC0</accession>
    <name>A0A398CHC0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_28270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000055">
        <property type="protein sequence ID" value="RIE00479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00479">
        <property type="protein sequence ID" value="RIE00479"/>
        <property type="gene ID" value="D3H35_28270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="226"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="994" mass="111370" checksum="2A78936620718E14" modified="2018-12-05" version="1">MKARLKYITSMDRRRPSLVVQCICSMPGARGIHRYDWGSCIQRTNISIELLYAGGSDRCCGEMYISGDGVSRGYLNQPELTAEKFVANPFAPGERMYRTGDLARWLPDGNIEYLGRIDEQVKVRGHRIELGEVESALRSHESVKEATVIARKDEEGSAYLCAYFVTNGNLGAAELRKHLSEMLPQYMIPSFFVRVEQMPLTPNGKLDRKALPSPEGTLERGTVYEAPRNALEETLANIWQGVLGVSAIGIADNFFELGGHSLKATTLVSRIHKELNVQVPLREVFQSPTIKELAQAIRGMEAHAYASIEPAPLREYYPVSSAQKRMYILSQLQGAEQSYNMPGAVMMEGKVDRERFERAFRQLIARHEALRTSFEWVEGEPAQRIHPEVDFEISYKKAEEGGLRQIAEFIRAFDLGQAPLLRVGLLELEPERQVLLYDMHHIISDGVSMDILVREFVGLYGGQTLPAPRLQYKDYAVWQQAFMQSEAMKRQETYWLETFSGELPVLEMPTDYPRPAVQSFKGDQIQFELDGELSAGLNRIAAETGTTLYMVLLAGYSALLSKYTGQEDIVVGTPIAGRPHADVENIIGMFVNTLAMRSRPAGEKTFTAYLQEVKEVALQAYEHQEYPFEELVEKLNVRRDLSRNPIFDTMFSLQNMSEEETEIEEMRFSPYGFEHSASKFDMSLTAVETGREIGLSLSYCTAIYTKETAERLGRHYVALLRDISSQTAKQLKDIELLSAEEKRQLLHAFNDTKASYPADQTIHGLFEEQVKKTPDHTAVVLESESLTYAELNGRANQLARVLRGKGVGADRIVGILAERSLEMIVGILGILKAGGAYLPIDPDYPAERIGYMLEDSGADILLTQKRLQGQTMGFAGEVLHVDDERLYAGDNTDLDHTGSSKDLAYVIYTSGSTGKPKGVMIEHRNVVNLVAGLANKIYAEYYLPLRIACVASYVFDASVKQIFASQLLGHTLYIVPKGRIRWAKAIAILQNASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHW0</accession>
    <name>A0A398CHW0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02030">
        <property type="protein sequence ID" value="RIE02030"/>
        <property type="gene ID" value="D3H35_14800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017410968" evidence="1">
        <location>
            <begin position="32"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="167" mass="17367" checksum="CD6AB15383061180" modified="2018-12-05" version="1">MNKMNKKILLISCLVVFVLAGTFYFKSVAEADVNESTPGLADDPIVTKSYVDKKVAELVAAELEKIGAGGGQGTGTMAQLEVVNVALGQKLTIAAGGELIVRTGKAIAFSSDTNGLSDMTDGLDIKPGAVVGNNHLILFPRDGRGVHPDPKGKVGLTVLVRGGYTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHW6</accession>
    <name>A0A398CHW6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Biotin carboxyl carrier protein of acetyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">accB</name>
        <name evidence="4" type="ORF">D3H35_26400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00729">
        <property type="protein sequence ID" value="RIE00729"/>
        <property type="gene ID" value="D3H35_26400"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001249">
        <property type="entry name" value="AcCoA_biotinCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01071">
        <property type="entry name" value="ACOABIOTINCC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00531">
        <property type="entry name" value="BCCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="3">
        <location>
            <begin position="82"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="160" mass="17161" checksum="AB6C920EAA8BA475" modified="2018-12-05" version="1">MFKLSEIKELIKLVDQTSVHELEIENEGARLAIRKPGRTEVVNVQTAAPIAHTYVQAAPAAAAPAAVAAPATETPSADSSNLHKIVSPMVGTFYRSPSPEAPSFVNIGDRVSDKSVVCILEAMKLMNPLEAEVKGEIVDILVENGQLVEFGQPLFLVKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI01</accession>
    <name>A0A398CI01_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sporulation integral membrane protein YtvI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ytvI</name>
        <name evidence="7" type="ORF">D3H35_19915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02886">
        <property type="protein sequence ID" value="RIE02886"/>
        <property type="gene ID" value="D3H35_19915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014227">
        <property type="entry name" value="YtvI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02872">
        <property type="entry name" value="spore_ytvI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="372" mass="40903" checksum="151313A51395F1E7" modified="2018-12-05" version="1">MDRRLAIAWRLIIVVAIIGGGCFVVWWALPLVYPFILGWLLAYALNPLVSFFHLKARFPRWLAVTLTLLLFTAAMLTIVSALVMRLVSQIMNLSGSLQSSVAWVETTFNAFLARPDIHDLIERINTFYKENPNYQETINSRVSDTAQALTAAGTSLIGGFLNGIVSVLSSLPEVATITVVVLLASFFISKDWHRHLSRLSDWFPEGLRRRTGEVAKDLKQALFGYVRAQLIMISITAVVVTSGLFMLGVENAISIGLLIGFVDLLPYLGVGAAMIPWIGYVFLAGDWQLGTGLSVLYGVVLVARQFIEPKVLASSVGLDPLPTLIAMFVGLKLFGFFGLIIGPVSIVVLTACHRARVFRDVGRFIRFGTGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIB3</accession>
    <name>A0A398CIB3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ZIP family metal transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03016">
        <property type="protein sequence ID" value="RIE03016"/>
        <property type="gene ID" value="D3H35_20690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="381" mass="40237" checksum="E172C0C46B0A3546" modified="2018-12-05" version="1">MGVGSYPLLLLVLIIYLISSLGTGIKDEPVAPIEALNVQKIVLTDEGFTLKVLNSGPDEATISQVLVNDAFWNVEFHPSATIGRLAQTEIFIPYGWVEGDPYEIKLITANGLIFSGEVAVAAKTPVPDGNRVAQYALIGFYVGVIPVGLGLLWFPFLRRFSDRGMQAVLALTVGLLFFLVIDTFEEGLELGAEAPGVFQGTGLVWFGALLSFLFLLALDQANERKGSASGKKIAYKIAGGIGLHNLGEGLAIGAAFASGEAALGTFLIIGFTLHNITEGIGIASPLLKERPTWRTFLALAALGGGPAIVGTWIGGFVFNDTLAALFFGIGAGAILQVIYVIGKMIVREAGKNGRPAVSWTNFASLTLGIALMYATALFVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CII6</accession>
    <name>A0A398CII6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sugar-bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_21380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SorC transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01009">
        <property type="protein sequence ID" value="RIE01009"/>
        <property type="gene ID" value="D3H35_21380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007324">
        <property type="entry name" value="Sugar-bd_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04198">
        <property type="entry name" value="Sugar-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sugar-bind" evidence="2">
        <location>
            <begin position="90"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="340" mass="37498" checksum="DCF927A74C5B3573" modified="2018-12-05" version="1">MRKILEIERKLIPDLMQVMHKRYEILQRIFLSGTIGRRTLAISVDLTERVLRTELDILREQGLVDTSAGGMALSEAGRQLVEELEPLVKELFGLSDLEKAMREAFGLSKVVIVPGDSDESDHVKREMGRAGGRVLRESLSRGDVVAVMGGSTMARMASQFPVSAPMRDNWFVPARGGLGESVDYQANTIAAELAKLTSARYRMLHVPDHLSEEAYQTIMQEPNVKEVVDMIRGARIVVHGIGDAMTMARRRKVGPDTMEEMKREGALAEAFGYYFDRNGQVVHRMATAGLRLEDIEAAGVVIGIAGGRSKGEAISSVLRFGHDDILVTDEAAAEEALRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIQ7</accession>
    <name>A0A398CIQ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VWA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03176">
        <property type="protein sequence ID" value="RIE03176"/>
        <property type="gene ID" value="D3H35_17560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="403" mass="43984" checksum="0B42F54709D99F54" modified="2018-12-05" version="1">MKDIDAEKLRRWRFVLGEAAEESLSSMAGGGGPLLTDEDSVMDAALAAIYDDTEAAGGGTLASPGAGGASRSAGLGKSSPRLAKWLGDVRALFPPDIVSVIQADAIERKGLQQLLFEPELLSQVKPDIQMVATLMSLRGQIPEKAKETARRLVHSVVEEIVKRMEQELRRAVTGALNRRQHSPLPSASGLDWKTTIRRNLRNYDRERGIVIPEKIYFFDRARRSKEWTVILDIDQSGSMAGSVIYASIVGSIFASMPSLDTRVVVFDTEVVDLSEQCAHDPVDMLFGIQLGGGTDINKSISYCETFIREPKKTLFILVSDLYEGGNQAEMIRRLGEMHQAGVKTMCLLALSDEGVPSYDERVATKLAKFGIPSFGCSPNRLPELIEGALKGMDLQVLADGLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIT1</accession>
    <name>A0A398CIT1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_22085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01109">
        <property type="protein sequence ID" value="RIE01109"/>
        <property type="gene ID" value="D3H35_22085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="34"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="115"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="180" mass="20756" checksum="1063248664907458" modified="2018-12-05" version="1">MDTISIQFSGLSVVVSFQQRILDKTALVLITIHDHTLAEDIIQDAFIKAITNGPKIRPDSNIPAWVKQVTRNTALDRIRKLKRDRQALTEVFLNIGAALDDTSTASKVEIKWRDELLHKVMAELNPDSRALLLMFYIEGKSYREICQELHISESVLTQRLARARKKLLHRFLRKWGDHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIV7</accession>
    <name>A0A398CIV7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 95 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03226">
        <property type="protein sequence ID" value="RIE03226"/>
        <property type="gene ID" value="D3H35_20775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901575">
        <property type="term" value="P:organic substance catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016518">
        <property type="entry name" value="Alpha-L-fucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007663">
        <property type="entry name" value="UCP007663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hyd_65N_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="780" mass="85964" checksum="02854806FB3E5188" modified="2018-12-05" version="1">MRLWYKQPASRWEEALPIGNGRLGAMVFGGVGKDTILLNEDTLWSGFPRDDANYEARRHLASARELLSQGKYAEAQRLIEEKIQGRNVESYVPLGGLTVELAGEDGPPGFYERDLDLGEAIASVIHRPHSGGGIRREYWISAPDQVMGIRYTAESGKELNAVVGMESPHPYLASGAAEAEAALTGRAPSHVADNYMGDHPSPVLYEAARGLSFDMRVRAIADGGTASADSDGKIHIRGAKSFVLYWTAATNFGGCGATPDPYDREPAERCRSRIAAAVEVGYDRLVARHKAEHGEKFNRVALKLGADDTDCERLPTDERLSLYRERENDPSLEALYFQYGRYLLIASSRPGTQPANLQGIWNPHVQPPWCSDYTTNINTEMNYWHAETCSLSDCHEPLFDMIRDLSETGARTANIHYGARGWTVHHNVDLWRGAGPTAGDASWAFWPMAGGWLVRHLWEHYLFGQSLDFLRERAYPLMKGAALFGLDWLIEGADGMLVTSPSTSPENRFVAPDGQIGSVSAGTTMDISILRDLFANCIEASERLACDAEFRELLRGALNRLPPFRIGSRGQLQEWLEDFEEAEPGHRHVSHLYGLYPAHLLTESRPDLIEAARVSLTGRLENGGGHTGWSCAWLINLFARLKDAGKSHEFVRTLLARSTLPNLLDDHPPFQIDGNFGGTAGMAELLLQSHDGGLELLPALPDSWGEGSVTGLRARGGFTVDMEWTGGRLQKAVIRSAAGRMCRIRNKEAWSVFAATDGEPVEVADGAFATAAHESYFIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ37</accession>
    <name>A0A398CJ37_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flagellar motor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_15295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MotB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02122">
        <property type="protein sequence ID" value="RIE02122"/>
        <property type="gene ID" value="D3H35_15295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025713">
        <property type="entry name" value="MotB_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13677">
        <property type="entry name" value="MotB_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="7">
        <location>
            <begin position="133"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="260" mass="29481" checksum="1D97E0B363BE3309" modified="2018-12-05" version="1">MPRRGKRRRNGASHENHERWLITYADLITLLLIFFVVLYAMSQIDVKKYDTLAESLTHQFRKADSVVELGTGITGAVDRSKYETPPPSATPSDDPQRDEDRIKEQELQDLLKIIQQYVKTNHLEQQVFVEDTPKGIAIRLSDVFLFDLGKADLKKPALPILDRLSSLFDKLDTTISIQGHTDNLPIQAGGSFQDNWGLSAGRALSVLRYFVDTRKVVEDKFEVAGYADTRPIAKNDSEANRQKNRRVEILVLRQATSNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ45</accession>
    <name>A0A398CJ45_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02132">
        <property type="protein sequence ID" value="RIE02132"/>
        <property type="gene ID" value="D3H35_15360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="430" mass="48715" checksum="D463C7501B3CA5D8" modified="2018-12-05" version="1">MCPDQLAQLQLVIPAMRTCPDQLAQLQTVISAMRTFPDQLAQLQTVILNKPMCPDQLAQLQTVIFTMRTCPDQLAQLQLVIPAMRTCPDQLAQLQLVIPNKRMCPDQLAQLQTVISAMRTCPDQLAQLQTVIPNKRMCPDQLAQLQPVIPTKRTFPDQLAQLQTVISAMRTCPDQLAQLQTVIPNKRMCPDQLAQLQTVIPNKRMCPDQLAQLQPVIPTKRMCPDQLAQLQPVIPTKRTFPDQSAQLQTVISTMRTCPDQLAQLRTVILNKRTFPDQLAQLQTVIFTKRTCPDQLAQLQPVIFTMRTCPDQLAQLQTVILNKRTFPDQLAQLQTVISTKRTFPDQLAQLQTVILNKRTFPDQLAQLQTVILNKRTFPDQLAQLQTVISTKRTFPDQLAQLQTVILNKRTFPDQLAQLQTVISTMRTCPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJD6</accession>
    <name>A0A398CJD6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_12285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03436">
        <property type="protein sequence ID" value="RIE03436"/>
        <property type="gene ID" value="D3H35_12285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="1174"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="1239"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="1308"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="932"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1368" mass="146980" checksum="FFB4512BA73EF02A" modified="2018-12-05" version="1">MGYVQLDVPRMTLEAPDRVASNVVKVVGLAPAGSGVRIYDDNVLIGTAEASAAGTWQGTVTLDSAAGSDDHLLWAQSVSGAKTLQSEHKLVHYEQSQPILTEVAMAQYPNGKWLRLNVENGIAQLPYTVVPGNPFAFNLKFSDPDKVKNVTVYLGGQIGGPVTAERGADGLFRATVPTTRGALGGLYVDYDTVKPKVVVSREIPTDEETRQSLPAKLRDFELVEKTPFTLKDNVYSGSAVFDFPQVPNMRLVAKQTIDLTPNSYRPTVEEIVKAEATGVLMYNVSFEAKETADGFVVKMKGYVPKTVLIPASVSGSGFDKEDVAGKSKGEVKSLASFDEVDPLEILDDMGIDPSPYKQGMIQVSTDYAMIAKEASGPLFDIKEQYKGYREYAGKINKIMSNVEAATVCPENMEMTGEQAGKALLVTVGGEIAKTAIGAWTGAMMLEGPVGFIGGYAGKYVSNKIDSYVDEQIDKITTAGPTPTENCMDDSYDDLDEENIYKKRLKRIARMKWIYDPSGYVYEAVEGNRLEGVKATVLYKDSASGKWAVWSDARDYDQINPQFTDKEGRYGWDVPEGTWKVVWEKAGYEPAGSAELTVPPPHFDVNAGLVSKASPTVADVKAYAGEGGSYIDIEFSKYLRTTTAIPATEITVTGPDGAVVEGTSAYVEKQKNPGRDQEWSRKIRFTPGATVLQAGDAYEIKVVPETIVSYAGSVMLDTVAKSAIAVEQDTRGPLPEKAEAASGNTVIKVYYDEPIDGDVLLSPESFELTGLNGEGIGINSAILSAVVERPEGNEQPTAVILTLSRPLSDGAGLKLNSKEGAVSDALSNPSQAKSVELAGPNASLSGLTIAGGTMTEPFASDKFSYTVKVAASATRLQLKATLAEAGGKLSISGVPLASGVERSVEIPTDGKIVILAQAANHPDIAKSYSLIVQRNGSDPDPGPGPGPGTGSGTGTESPTGDKGDIGHNAKVISKTESDGRTGVVIDIKAETVRDALKSAVSGDEMFVKVPENADSYDVRVPIDAFRELAQSQLKVNLQAGNQTVLVQPSAWTTNVTDRMSAVHFIIRRASVQEERSWLDGLKARFGSLIPQSGLYKFAVEAEAEGGVVVLPLAVPNAVFVKWELAKEPPARQGTTGLYRYNASEKQWTHVIGAADSQSRNIEFALRDSNYLSVMTYVSEFADIANHWAKAQIDWMAARMLVSGYSEETFKPDRKVTRAEFAAMLARVLGLKPPVEGGPSFADVKPGDWYYDAVRAAAAARLIAGDGNGRFEPTELVTREQMTAMTWRAYKQITGESGAAPGEEEQRRLLEPYQDRNAIHDWARSDVAAAIQSGLAQGVSGSRFNPGGVATRGQAVTILKRIAEKLENKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJU1</accession>
    <name>A0A398CJU1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_22130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01118">
        <property type="protein sequence ID" value="RIE01118"/>
        <property type="gene ID" value="D3H35_22130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017294822" evidence="4">
        <location>
            <begin position="37"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="5">
        <location>
            <begin position="109"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="564" mass="60867" checksum="E6ACDADE4323E2E0" modified="2018-12-05" version="1">MKPIAKRSKLGLTFVSLLLVLSALSACGNNNNNKEGASSPGAASKPPASESASASASPQASATQGGVLTYALATSPDTLDPARSGLAVASRVYKTIFDNLVVTDADNNIKPWLATEWTAGEDGLSYTFKLRQDVKFQDGTPFNADAVKFTFDRIKDPATKASNAAAQLSAYASSEVIDPYTIKLNLSTPSRAFLGNLSTSTLGIVSPTAVQKYGEQFGKNPVGTGPFKFVKWEENADIQVERNPDYAWAPGNVDNQGAAYLDGITFKIIPEEATRIGSVQSKQILAAETVPPQNVVSIQGDSSLQLLKVNTVGLPYTLFLNQDKAPWNDVKVRQALQYGIDVGAIVKTLYLGTYEQAWSSLTPGIFGYDASLEGSVKPDADKAAKLLDESGWVTGADGIRVKDGKKLTLHYVDGTPNREKRNDIAVIIQQQLKKIGVEVNIELTKDVLTKVFKSRDYDIYGNSQVNSDPNALYAFYHTAAPGGFGNIAGVSDTQVDQWLEQGAVEKDDAKRAELYKNVQQYIKDNAVIIPIYVFPYTVAAGKSVQGLKFDKSGYPLFNDVNLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJU7</accession>
    <name>A0A398CJU7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02973">
        <property type="protein sequence ID" value="RIE02973"/>
        <property type="gene ID" value="D3H35_20435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017414713" evidence="1">
        <location>
            <begin position="35"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="766" mass="86829" checksum="3C3ECD0997EEFABC" modified="2018-12-05" version="1">MNGNKAQRARRLICALLILIVLITGCNNAGNNPAVESGSLFEEKEISIQTDFELLSIRKANDKFVCSYRDPQDHSYHLAYTDSKFTKISPILNDAGNLIPAAELLDIENPYGKFNIGARLVYDLDDNGNIYILQYETVKKDDLPYPYGKKMIFAYNKDGVLTRKISIENSDRIPDMQPGEIIAQDNRFIIVAGTGIQMVDLEGKTIGEIAVPSNKAVDVVNKQEQTVSIGRIIDAALINKNEMVILQDQMDRIDLIAYNLSNQKNVWTKTFREHFLPVKIQFEKEQDRIFVASNDKVISFGADGAETGEVIDFNQYAAGIDNSTIMNGDKALAPGYFVFEQPDFMNVYMVTSPIDPQINKIYSYRTLTGNEKAERMAAIEKEQAKKTNVTLFVPFIEYGLEQKIAQYERLNPHIKINLISYRKDAEEFNPAEYSKYADSQLLSNKTRWDIMAVQLLPYEDYIKKGYLADIDQIASEQWIKGKERFFPNIIDSVRVDGKLMIVPARIAMHVNLADKKTARDLPPLQYKWSDLIRLSSDAKKSNSGIKSWSFFGSNGYQFPFTYEEIMDSFQTDLLSAQGSPEGQKQLLTQFLDTMKAIGIKGDHAQPPGDNPLFHLTPFIPSHFPNYIELIGNEKMLLPSPASPKSGKHSFTLQEGYSINEDSKVKEEALKFMLFLIESVDPNNLIFKKSFDNLKEQLGTSDQRRNAIEQLRTIVASLNALRDLDNRITDAVLSRTEQYVNGITDKETAVRTIQDKLREIERAYPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKN5</accession>
    <name>A0A398CKN5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02935">
        <property type="protein sequence ID" value="RIE02935"/>
        <property type="gene ID" value="D3H35_20220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="1">
        <location>
            <begin position="215"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="384" mass="44397" checksum="EFE55FD31552D33D" modified="2018-12-05" version="1">MSTRIFLYERANLERIDWPDSVDGRYARAYLEPLVREGTDRYIRNVRTTMLLMRIDDLILPITVNDGEYDNCYVCSPYTHYIRYAKRELELLNRPVMEKSLSALLDVLGYFMKRSHLNRVVHINNWLLSTNLYPPLSGEQAKAVLNAVREAFPEHAIVFRSLCPSLHAEMIADLRAEGCKLVPSRQIYLYRSNDPTFGNAKARWLLKRDYELLSDNGYEFVSAGDITDDDISRIVELYAMLYLDKYSYDNPQFNEEFIRLAKRSGALTLYGLRKNGRLDAVMGYFSRTGVMTTPLFGYDTTLPQSVGLYRMLSACLMRQARETGHLLHESAGAAQFKRNRGAIAEIEYSAVFDRHLPLGRRWCWSLLERLLNGIGVPLMRKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKS7</accession>
    <name>A0A398CKS7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_19160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02762">
        <property type="protein sequence ID" value="RIE02762"/>
        <property type="gene ID" value="D3H35_19160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13124">
        <property type="entry name" value="MATE_SpoVB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024923">
        <property type="entry name" value="PG_synth_SpoVB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038958">
        <property type="entry name" value="PG_synth_SpoVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="367"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="544" mass="58032" checksum="F06B5F27B230A5E4" modified="2018-12-05" version="1">MPLKKDTLLKGTLILAAAALVARGLGIFQRVPLDYVLSDAGNGYFGVANNVYLLLLVVATAGIPSAISKMVSQRYALGRVGEAQQVYRAAMLFGAAAGIVITLGMLGLAPLIAGPILDEPEAATAIRAIAPSLLLFPMIAMMRGYFQGRQFMAAGGISQIVEQILRVVAAVAIAFAIYAGSPHNDEGIAAGASLGSVFGSIGAFAVMLYYARKLKARDRLEPLAMRDTSRSLKLKEIYRELFRLSIPIVMTAITVQFVYTLDGIMVKSLTRGHFDPDLILHWWGVLSMNAQAIAGIPVILAVALSQSIIPIISAAHAVGDHNRVGNQASLAVRIAIYTGMPMILLLGVGAFSVNGLLFEKPEGSSIVAMLTLGTLFQIGMMVTNSILLGLGKPKKATMHTITGIIIKIILSFALAPWMGVYGIILSTTICFIWALFFNVLSLRKRSTFNVIGKAWPGYIATVAIVAGALWLLQKGVLAILSGAPDKVAFFFSCAVMGVGVLALYPTLLVLFRVITAEEMASYPRPVRKLLGPVFKLVGRTPQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKT7</accession>
    <name>A0A398CKT7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_13575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01819">
        <property type="protein sequence ID" value="RIE01819"/>
        <property type="gene ID" value="D3H35_13575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="104" mass="12063" checksum="DCA7D2174C9C0B48" modified="2018-12-05" version="1">MDRQRYYVSVQAKTITNHQGDAAYEFAIDALPEDIDKLQELFAAMEEFDEMSFIRNPLPGIPYHHDSENDGYDYYLKESYKLIGQLSDEKTRSFIASMPLNAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKY9</accession>
    <name>A0A398CKY9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_19690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02852">
        <property type="protein sequence ID" value="RIE02852"/>
        <property type="gene ID" value="D3H35_19690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017362335" evidence="1">
        <location>
            <begin position="34"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="72"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="355" mass="38633" checksum="F2614BEF34BA49BE" modified="2018-12-05" version="1">MKIVKQRSIYGILAIMTALAVLLSACGKENDKAANASPSAPAESGAAQTQEIKSDPIKIKIADILSNPVLRVAKTKGYLDKYGIDAEIVTFATPAEGINSLFIKQVDVAWGADFPVLNAVSKGDYSIIAATGTNTDIAASQWKLYVRDDIQKAEDLKGKKLSTLRGTFLPYLWDAYLTENGIALEETKQIGQGGFDEAYVALKKGEIDATWVVGSALLDKFKAVEGIRELTDMSKTKVRIGGGIVAPNDLIKDHPQGIANFLAALDEASKYITAHPNETADILFKEVKQPKEATIRDIPTNNWEIGFKQESFDSLTSQKKYMVDAGIIKEDFELTSKLALDGVRQAIPERVTYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKZ0</accession>
    <name>A0A398CKZ0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative N-acetylmannosamine-6-phosphate 2-epimerase</fullName>
            <ecNumber evidence="6">5.1.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ManNAc-6-P epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nanE</name>
        <name evidence="7" type="ORF">D3H35_24790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23932"/>
            <dbReference type="ChEBI" id="CHEBI:57599"/>
            <dbReference type="ChEBI" id="CHEBI:57666"/>
            <dbReference type="EC" id="5.1.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the NanE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.9" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01568">
        <property type="protein sequence ID" value="RIE01568"/>
        <property type="gene ID" value="D3H35_24790"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047465">
        <property type="term" value="F:N-acylglucosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009385">
        <property type="term" value="F:N-acylmannosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006051">
        <property type="term" value="P:N-acetylmannosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04729">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01235">
        <property type="entry name" value="ManNAc6P_epimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007260">
        <property type="entry name" value="NanE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36204">
        <property type="entry name" value="PTHR36204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04131">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="233" mass="25554" checksum="5F1DD6A8B7C7F7E9" modified="2018-12-05" version="1">MLTSKWFEKRGLIVSCQALPDEPLYSGDTMTKMAKAAEMAGAIGIRTNGEEDIRRIKQAVNLPVIGLIKRVIPDSAIFITPTLEEVKAIIEAGADIVALDVTERENRLEQVNLLIDYAHEQGVGVMADISTLEEGLAAERLGVDLIGTTLSGYTPYSPQQEKPDFLLIERLSELVKVPVVAEGRIWTPDEAARALEAGATYVVVGSAITRPQLITQKYMQALTKYSNRNTEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKZ8</accession>
    <name>A0A398CKZ8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03333">
        <property type="protein sequence ID" value="RIE03333"/>
        <property type="gene ID" value="D3H35_11640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="139"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="326" mass="35801" checksum="2405033C4AB4DF18" modified="2018-12-05" version="1">MIRKSPARIAAMLIALWAVWMAGTYGPLAPFVEAVKLRSSETAAVSEELKGVGLKEWIEAEAAKRKIEPADAVIDRVWKAIPGYNGREVDVHATYSRAKALGVLPGSADFPWVYRELTAKVRLDDLPYMPIYRGNPAKPAVGLMINVAWGDEYLARMLKTLDKEKVKATFFFDGTWLAKHKELAAEMMAKGHELSNHAYTHPDMSKLSLQRQKEEIGKTEALLKELGAGNKWFAPPSGDYDARTVRAASEFGLRTVLWTIDTIDWKNPPSSAVVAKIAARVGPGNLILMHPTKASDGALSGMIEAIRAKGYAPGTVSEALSPRRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL68</accession>
    <name>A0A398CL68_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_20310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02952">
        <property type="protein sequence ID" value="RIE02952"/>
        <property type="gene ID" value="D3H35_20310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="334" mass="36015" checksum="DAA23E42274911EE" modified="2018-12-05" version="1">MDHWAVEAHGLVKAFGNNRAVDGVNLNVRAGSIYGVLGPNGAGKTTTIRMLATLLRPDAGSARIFGHDVAKESQIVRQLIGVTGQYASVDESLSATENLIIFSRLLGLGRAEARRKAEELLEEFGLSEAAKRPLKNFSGGMRRRLDLAASLIAQPPLIFLDEPTTGLDPRTRAQMWETIRRLVKTGSTVLLTTQYLDEADQLADRIAVIDRGQVVAEGTVDELKTSVGTSSLQLKVQNPQDIEDARRTIEQVLKVQSSMSSEAGKITAPMADADRVTDLLIALRAAGIHLAEISVQKPTLDEVFLTITGHGVKEDESLASLASDESNRAEAAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLA8</accession>
    <name>A0A398CLA8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01688">
        <property type="protein sequence ID" value="RIE01688"/>
        <property type="gene ID" value="D3H35_24140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="223" mass="24373" checksum="5F73E83E76669DE8" modified="2018-12-05" version="1">MNEVKDALPYEFAFDPNRTALVVIDMQNDFCSPGGFGEKLGNDIAPARAIIPVIRKLLQSAREAGLLIVHTREGHLPDLSDCPLAKLERSRRQGAGIGDEGPMGRILVRGEPGHAIVPELAPLEGELVIDKPGKGAFYKTNLEPLLERNDIQSLLLCGVTTHVCVHTTLREANDRGYRCLVLEDATAAFDPADQQAALHMVRQQGGIFGWTSFAQPLMEALER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLF0</accession>
    <name>A0A398CLF0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_20920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03052">
        <property type="protein sequence ID" value="RIE03052"/>
        <property type="gene ID" value="D3H35_20920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="234" mass="28041" checksum="583C7EA96F4A47A3" modified="2018-12-05" version="1">MRALYSGTRYHTFGDWRARALYSGTRYHTFGDWRARALYSGTRHLTFGDWRERALNSGTRYLTFDDWRAWALNSGTRYLTFGDWRAWALYSGTRYHTFGDWRALYSGTRYLTFGDWRAWALNSGTRYHTFGDWRAWALNSGTRYHTFGDWRAWALYSGTRYPTFGDWRARALYSGTRYLTFGDWRERALNSGTSTTRCREKRLRKTKRLSLRDNLSYKLYPSLRWKVRNEGLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM34</accession>
    <name>A0A398CM34_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03505">
        <property type="protein sequence ID" value="RIE03505"/>
        <property type="gene ID" value="D3H35_12720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017232730" evidence="1">
        <location>
            <begin position="18"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="114" mass="13191" checksum="E1E6A53BF090028A" modified="2018-12-05" version="1">MPYRNRIRRSTCKSSRSRRCRLFPVAGRRPEAERLSEIVVELKRDGERSVSVSLNPESLEVEASLPFPIGDVILRREDSGEYSCKVTAIRLSGETVKDWKRRPDRLFILQDDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM71</accession>
    <name>A0A398CM71_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aconitate hydratase</fullName>
            <shortName evidence="10">Aconitase</shortName>
            <ecNumber evidence="10">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">acnA</name>
        <name evidence="13" type="ORF">D3H35_16505</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="10"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02319">
        <property type="protein sequence ID" value="RIE02319"/>
        <property type="gene ID" value="D3H35_16505"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="PTHR11670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase" evidence="11">
        <location>
            <begin position="74"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="12">
        <location>
            <begin position="699"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE02319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="903" mass="98022" checksum="108242E6503DC55B" modified="2018-12-05" version="1">MSKLPYQVQADLQSSGQSYRYYRLQALEEQGLGPVSKLPFSIKVLLEAAIRQHDGRGITNEHVKQLATWAEGREDKEIPLIPARIVLQDFTGVPVVVDLAAMRETVKQAGGDPNRINPLVPVDLVIDHSVMVDAFGTADALKTNMDIEFERNGERYRFLRWAQTAFDNFRAVPPATGIVHQVNLEYLASVAATKSKDGVTEVYPDSLVGTDSHTTMINGLGVVGWGVGGIEAEACMLGQPLYFVMPEVIGFKLTGKLAEGATATDLALTVTQILRKKGVVGKFVEFFGPGLSNISLADRATVANMAPEYGATIGFFPIDEEALNYLRLTGRDEKQIALVSDYYKAQDMFRTDETPDPVFTDVIELDLSTIVPSLAGPKRPQDRVELTNMKKEFNEIIRTPIDKGGYGLSEDKIVETVAVSHPNGQTSSLSTGAVVIAAITSCTNTSNPSVMLGAAIVAKKAVERGLKKPGYVKSSLTPGSLVVTEYLTKSGLLPYLEKIGFYVAGYGCATCIGNSGPLPDEVSQAIADNDMTVAAVISGNRNFEGRVHAQVKANYLASPPLVVAYALAGTVNIDLAVDPIGFDDNNEAVYLKDIWPTNEEIQQALNSSLNPAMFRAKYENVFTQNEQWNQIPVPEGDLYEWDEQSTYIANPPFFTDLGPTPGDIGDINGARVLALMGDSVTTDHISPAGNIKADSPGGKYLLDHGVDKKDFNSYGSRRGHHEVMMRGTFANIRIRNQVAPGTEGGVTTYLPTEEVMSIYDASMKYQASKTNLVVIAGKEYGTGSSRDWAAKGTFLLGVKAVIAESFERIHRANLVGMGVLPLQFQPGTGWKTLGITGRETFEINGLSNDVQPGQTITVTAKREDGTTFEFPAIVRLDSLVDVDYYRNSGILQTVLRQMLAGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM99</accession>
    <name>A0A398CM99_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_11095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03575">
        <property type="protein sequence ID" value="RIE03575"/>
        <property type="gene ID" value="D3H35_11095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="61" mass="7278" checksum="A5538CFAA915523F" modified="2018-12-05" version="1">MRQRVTEREERMRGEIAMCQRVTAREERVRGKIAMRQQVTTRHSSLFALAHARYVQVMSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMI7</accession>
    <name>A0A398CMI7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YpdA family putative bacillithiol disulfide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ypdA</name>
        <name evidence="1" type="ORF">D3H35_14620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01998">
        <property type="protein sequence ID" value="RIE01998"/>
        <property type="gene ID" value="D3H35_14620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023856">
        <property type="entry name" value="Bacillithiol_biosynth_YpdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04018">
        <property type="entry name" value="Bthiol_YpdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="351" mass="38236" checksum="E7BD7F75D9E2CB6F" modified="2018-12-05" version="1">MSSVQEEDIVIIGAGPCGLSAAAELQDQGFDPLVIEKENVVNSIASYPTYLEFFSTPEMLEIANIPFVSPHEKPNRLEALNYYRTVAERKKLRIRRYEEATAIVPEGKGFRIESTTKYGGERLVTHARVVVVATGYFDHPNRLGIPGEHLPHVTHFFKEAHPYAGTKVVIIGGSNSAVDAALELMRVGASVTVVYRGESVSDNIKPWVKPIFESFVAKGRIDLRLRSRVVAIEPARVTVRTNDEAGSDGAARTDSAAREKVEADFVLALTGFRPNRAFLRAIGVEAPEGNVPPTHDEVTMETNVPGLYLAGVVATGRDANEIFIESGRNHGKKIAAHLASLRDSATAFSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMM4</accession>
    <name>A0A398CMM4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_03740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04616">
        <property type="protein sequence ID" value="RIE04616"/>
        <property type="gene ID" value="D3H35_03740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="98" mass="10960" checksum="C2E86579D3DD2F7B" modified="2018-12-05" version="1">MNDREPGSAWERYRYAKKNALEQAEEPQGEPMTLDELEAAIAQTAASSGIPETGMPPRSVVHPSKRGQGTKLFYRLLLFLFILLVGGLLWWGNKHYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMT5</accession>
    <name>A0A398CMT5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Catalase</fullName>
            <ecNumber evidence="10">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D3H35_22745</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="10"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01217">
        <property type="protein sequence ID" value="RIE01217"/>
        <property type="gene ID" value="D3H35_22745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="PTHR11465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="12">
        <location>
            <begin position="15"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="369"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE01217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="543" mass="61727" checksum="4E34F5547AA07083" modified="2018-12-05" version="1">MTEKNPNDVHRETLTTRQGHPVTDNQNIRTVGNRGPATLENYHFIEKISHFDREEVPERVVHARGAGAFGYFEAYGKVGNEPVEKYTRAKVFSGAGKRTPLMVRFSTVAGAKDSPETARDPRGFAVKMYTEDGNWDLVGNNLKIFFIRDAMKFPDMIHAFKADPVSNVPNPQRMFDFVSRTPEATHMITFLFSPWGIPATYRYMQGSGVNTYKWVNDKGDAVLVKYHWEPKQGIRNLLQEDADMIQAKNVGHATQDLYEAIGRGDFPEWELFVQIMEDDYHPELDFDPLDDTKLWPEDKFPWRPVGRMVLDRNPVDFHAEIEQAAFGTGVLVDGMDFSDDKMLQGRTFSYSDTQRYRVGANYLKLPVNAPKAPVRSNQDRGQMDIRDPKESGESPHINYEPSLIGGFEEASKENRPPHQPSYNAAVMSAPIDRPNNYGQAGETYRKLDDWEREELIKNLSEALAVCDKRIQEAMIGHFTQADEEYGRRVKEGIEKKTKEIEQMKTEYTAPGRDAGISKYGQGSLDANQAVKDSVKKSRATDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMU3</accession>
    <name>A0A398CMU3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bshA</name>
        <name evidence="3" type="ORF">D3H35_04100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04676">
        <property type="protein sequence ID" value="RIE04676"/>
        <property type="gene ID" value="D3H35_04100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071793">
        <property type="term" value="P:bacillithiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023881">
        <property type="entry name" value="Thiol_BshA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03999">
        <property type="entry name" value="thiol_BshA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="196"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="387" mass="43297" checksum="C84BBE65294C219A" modified="2018-12-05" version="1">MIRPLKIGITCYPSLGGSGVVATELGKLLAEKGHEIHFITNSIPFRLGKFHRNIFYHEVEVSDYYVFRYPPYDLSLASKMNQVARLQGLDVLHVHYAVPHAICAFLAKEMSGDKLKVVTTLHGTDITVLAQDESLKDIIRLGIRKSDAVTAVSQDLIRETRELLEIREPIDLTYNFVDKRIYYPRECSDLRREFVRPNEKLLMHISNFRPVKRTSDVVDIFAKVNAEIPSKLLLVGEGPDLPKIQTKIMQMGLANKVHFLGKQDDVAHVISIADLMLLPSEKESFGLVALEAMACGVPTIGSIAGGIPELVQHGVTGFLAPIGDTDQMASYALQLLKDPELFAKFRKACISRATQQFCNDLITAQYEQIYYRVLGIPYEVPIPVCEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN39</accession>
    <name>A0A398CN39_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">folK</name>
        <name evidence="9" type="ORF">D3H35_23420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01327">
        <property type="protein sequence ID" value="RIE01327"/>
        <property type="gene ID" value="D3H35_23420"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="8">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="161" mass="18045" checksum="4AAE74D492DAD906" modified="2018-12-05" version="1">MNEAYVALGANLGLREASLEEAVRRIAAEPGVEVRRVSSVYETDPVGYTDQPAFLNMAVQVSTEASPLELLRKLLAIEHEMGRVRDIRWGPRSIDLDLLLYGEVTMDTEELALPHPRMGERAFVLVPLRDIWTGSSFPWDIPAEQQEGICLWGRIDGLREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN49</accession>
    <name>A0A398CN49_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide diphosphorylase (carboxylating)</fullName>
            <ecNumber evidence="4">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">nadC</name>
        <name evidence="12" type="ORF">D3H35_23470</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NadC/ModD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01337">
        <property type="protein sequence ID" value="RIE01337"/>
        <property type="gene ID" value="D3H35_23470"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="11">
        <location>
            <begin position="30"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="10">
        <location>
            <begin position="121"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE01337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="298" mass="31698" checksum="94F816662A4484B7" modified="2018-12-05" version="1">MFERESDWLIAGPALESVKQQLRAWLTEDVGTGDVTTMATVPAGHQSKGIIHAKAPGIVAGLPLVRLVFGVVDPSLTVETYATDGARIEKGAVLAVVEGSTASILTGERLALNLLQRLSGIATKTAQYTQAAQDYPSVRIADTRKTTPGHRTLEKYAVRVGGGSNHRFGLYDAVMIKDNHIKAAGGITEAVQAAKSRIPHTMVIEVEAENAEQAEEAAKAGAHIVMLDNMSPERMKEAVKRVREIAPYVVLEASGGMRPEQIADVAASGVDIISVGSLTHSFEALDISLDLNAKKKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNB3</accession>
    <name>A0A398CNB3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_21850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01071">
        <property type="protein sequence ID" value="RIE01071"/>
        <property type="gene ID" value="D3H35_21850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="71"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="277" mass="31324" checksum="523B66F15B003C6B" modified="2018-12-05" version="1">MRDDKYNLRRFSLEVLCYLLGLLFLIPFYFVLSNSVKSFSDLLSNSASWPQSFVWSNYSRTWEIMNYPRAFMNSFLITVVSIAGIVTISAMAAYRMVRRPTRFNNFLFGLFVSAMIIPFQAVMIPLVKVLGWADLMNSRTGLIISFFGFGASLSIFLFHGFVKSIPLEIEESAIVDGCTPYGVFWRIVFPLLKSATVTIVLLNSLWIWNDFLLPLIVLYDPDKRTIPLAIYAFFGQYSKQWDLALAGLVMGIVPILALFLLLQKQIIAGITAGAIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNC2</accession>
    <name>A0A398CNC2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PilZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_09675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03812">
        <property type="protein sequence ID" value="RIE03812"/>
        <property type="gene ID" value="D3H35_09675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="2">
        <location>
            <begin position="27"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="171" mass="20159" checksum="618B7CCFBAE75FC8" modified="2018-12-05" version="1">MEKQLSISRRRDSMFQSMQHERAEADNRRRHVRLQLAEQSHALIRIVKLEGYEVDMNPGVILLENLSPDGCGFRTGLRFPAHSKVIYKVEWETEGKRMELRGTIRWRSKDENGYRYGLRFLPNIAERMLLTGILNRLILKTCPGQERIHRLYRSQIGADRSFGFVQRKGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNG0</accession>
    <name>A0A398CNG0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_02170</name>
        <name evidence="2" type="ORF">D3H35_29045</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00454">
        <property type="protein sequence ID" value="RIE00454"/>
        <property type="gene ID" value="D3H35_29045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05197">
        <property type="protein sequence ID" value="RIE05197"/>
        <property type="gene ID" value="D3H35_02170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033365628" evidence="1">
        <location>
            <begin position="23"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="376" mass="41638" checksum="92DCE3D66177B555" modified="2018-12-05" version="1">MAIVVAASALFGLSKGYPHAFAAGSPWSDPVVVSVRVSPDATYETRLAVGHLHIGQSSQQREEDSSKFAPILTDIYVRVSHGGLPKLYRLESSGRLWNEEERLNVSLPEKLSAKLLKEADKARAAHYGEAIAWKEAKRILPRKSVFKVMDMKTGLVFRVQRRAGSDHADVQPISREDTKIMNEIYGGQWSWNRKAVVVLAAGRRIAASMNGMPHGGDGIPDNGFSGHFCIHFSESTTHKSSVPDPAHEFMVHRAAGDARAYLDSASPSLLARSLVEALNQRDREWIRLLAEGSERDEAASLIGETDSVTSARTVAQRQPLPEEDRLVATLESEVAIERRGKGKRHLPFRFEFARLSPYSPWRLQSVERGPSEGKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNH4</accession>
    <name>A0A398CNH4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03872">
        <property type="protein sequence ID" value="RIE03872"/>
        <property type="gene ID" value="D3H35_10000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="253" mass="28468" checksum="81B434B16B6F515C" modified="2018-12-05" version="1">MEEIRKEAKRHYPDLIFYTEGMALLRQSTTSFATTTIFIGYTRIIACPGRTGNVDDVLEPGIGKYAELDDLAQWLEEQRTTVPPGLTIVHQTDSHDSHEWAAFWQGQFHRKLSDLVCTGYTRRWLCSWTAALCLFTARSSQRGLLCPAVANEGSAVVLARKMQLYGCLDERYESVLRGLDERERMASLSAIWRIGRRSGGRLFSGIGYRLEARGSDPQLLDLAGDGKLSVQPRRPHRLFMAPCGVLVLSNTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNJ7</accession>
    <name>A0A398CNJ7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VanZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_09665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03810">
        <property type="protein sequence ID" value="RIE03810"/>
        <property type="gene ID" value="D3H35_09665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016747">
        <property type="entry name" value="Phosphotransbutyrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019083">
        <property type="entry name" value="UCP019083_VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="10"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="167" mass="19014" checksum="3DAE147AEC925483" modified="2018-12-05" version="1">MEARKLLYLFPAILCLIMVFGFSSQPYNQQSVIPFLQKHITEYRLAEILPNIHFRYGHTELWSKIAPYQFVEFVFRKCAHIFSYSALGCSLYYAFSAFGAAVWKPGLRIIAMMLGLLAVAALDEWNQIRVSMRTGQPIDVALDVIGGTLGALSALFVFGRVRARWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNJ9</accession>
    <name>A0A398CNJ9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein L11 methyltransferase</fullName>
            <shortName evidence="2">L11 Mtase</shortName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">prmA</name>
        <name evidence="3" type="ORF">D3H35_06065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Methylates ribosomal protein L11.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:54192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13826"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the methyltransferase superfamily. PrmA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04183">
        <property type="protein sequence ID" value="RIE04183"/>
        <property type="gene ID" value="D3H35_06065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00735">
        <property type="entry name" value="Methyltr_PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004498">
        <property type="entry name" value="Ribosomal_PrmA_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000401">
        <property type="entry name" value="RPL11_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00406">
        <property type="entry name" value="prmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="329" mass="35930" checksum="540591333ADD344B" modified="2018-12-05" version="1">MRWHELTILATEPSQEMVSHYLYELGAAGVSIEESWTEDKPRDTSLGQWYDKPLNNIRAGYAEIRSYFADETDVESVVKQLTALLEGLPEFGYDAGEFTIAAGEVDDEDWADSWKKYFKPIQVTEKLTIKPTWEEYEARPEEVIIELDPGMAFGTGTHPTTVLCLKTLEGAISGGEEVIDVGTGSGILAIGAMRLGAKRVLALDLDPVAVSSATENIKLNGLQDDVEVKLSDLLGILRDSGIDRPNGVKPPVDLVVANILAEIILLFIADVMEVLKPGGIYIASGIYKNKEQDVEAGLLAAGFEIVDKVRQDDWVAFVAGKPKGDDEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNQ1</accession>
    <name>A0A398CNQ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03870">
        <property type="protein sequence ID" value="RIE03870"/>
        <property type="gene ID" value="D3H35_09990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="98" mass="11221" checksum="D0BB3847F5D14358" modified="2018-12-05" version="1">MQRHRLREYSSKPRCSARKTRGRIIVAPIEFPSVESQKEFYSYLESLSSKLSDQSIPVVFINNDLQETSLSCVSIDNYLSARLAMEHLLAWDISALPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNR2</accession>
    <name>A0A398CNR2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_06400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04243">
        <property type="protein sequence ID" value="RIE04243"/>
        <property type="gene ID" value="D3H35_06400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PTHR12049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="402" mass="45158" checksum="00CF355A619FB60E" modified="2018-12-05" version="1">MRNRQEVKGLPAVVRDAATAASRIGQTDDGERRTCITFRDYMELCLYHPEFGYYRSGSSRVGREGDFYTSAYVGDIMGEQLAERLTSLADEHFGPEERVEVIDWGGGTGRLSRHMLEAWSRSSNPIAGAGRMSITVADRNPAHRALAEESLADWIGSGRARVVDPDRQWPWSDGKGGADVGDAERGKSPVIIVANELLDAFPVHRLTCLNGGLLEQGVAWDEEKERPVACLTELSDPRLAAWLEREGLALAEHQMIEISIDAASWIGSLPGRFERAILVLIDYGDESEELISSHRMEGTLMCYFRHQAHDDPFIHLGEQDITAHVNFSILRKEAKASGWREIWYGSQKRFLVESGLLEKLVAHTVTDPFHPTVRRNRAIRQLLLSDGMSELFKVQIWEKTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNX3</accession>
    <name>A0A398CNX3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_17235</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02448">
        <property type="protein sequence ID" value="RIE02448"/>
        <property type="gene ID" value="D3H35_17235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="117"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="184"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE02448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="392" mass="42817" checksum="92C25EC4BFED176F" modified="2018-12-05" version="1">MGQITARLRNLSFKASFVLYVTACVLSAAALSAGILHLTTVWNERIYSAGETTGATYYLTTKDGERLGDGVVVNTDPPWLSASDKRKVAVLQAVSAASIPVVFSVCVVVSAFLFYRNKLKKPLALLTAASGQIEQNNLDFSVAYGANDEMGRLCDSFEKMRAALRENQLEMWRQVEERKRLNAAFSHDLRTPLTVLKGHSDMLLKYVPDGKMSSEKVAATAAVIKSHILRLENYVDAMSRLQKLEDIAFCKAYVTAGELVERLHASGEILCAGNRLQVDNALADDDSFHVDVSFVMQVYENLLSNAARYAQSQIRVTLAGEGMLSLTVSDDGHGFSGKDLLEATKPFYRSSDSSDKTHFGMGLTICKVLCEKHGGSIRLYNDSGGAAVKAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPC5</accession>
    <name>A0A398CPC5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_07230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04375">
        <property type="protein sequence ID" value="RIE04375"/>
        <property type="gene ID" value="D3H35_07230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="222"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="433"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="584" mass="65289" checksum="0374CB079347E7DB" modified="2018-12-05" version="1">MESGGTGHHGGKETRAGRLSIVGVPPPLLIQSDGTILLDERHPRYEETRETLRQLAELQKRPGPLHTYRLTPVTLWNAAAAGWTADRAVSELAESARYGLPGELEKEIRTQLGRYGLLRLDREDNNLVLRSNSEQLLREIADWPDIAAWVSKTNESSGLTLKAEARGFVKRELAARGYPVLDEAGFRSGEALSLSMRSLQTDNGRPVRLRDYQSAAVDAFLGQSAQGGGSGVVVLPCGAGKTWVGMETLVRLQCETLILTPNAVSVTQWIRELRANTSLSENEIGEYTGTAKQVRPVTVATYQVLTHRRSKDAPYPHWKLFVDRDWGLIIYDEVHLLPAPVFRMTADIQATRRLGLTATLVREDGREEDVFALIGPKKYDVPWKQLEAQKWIAEATCTEIRVPMGDRTIDRYRSATVRARHRIAGENPVKTKVVRRLLSRHEGIPTLVIGQYLDQLHGLSRELALPLVTGEMPHKERRMVFDRFNRGEIGVLLVSKVANFAVDLPDAAVAIQLSGSFGSRQEEAQRLGRILRPKKDGSNATFYSLVSEGTDEVDFARNRGRFLIEQGYTYSIDREQLEARAEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPD4</accession>
    <name>A0A398CPD4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04443">
        <property type="protein sequence ID" value="RIE04443"/>
        <property type="gene ID" value="D3H35_07615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="63" mass="7071" checksum="1AE3FE9356A1C43C" modified="2018-12-05" version="1">MNQGSLIAEAFLFDARDKRRTGANSIGQDRQKGNLGVIDRKTVFEKLLPPHPARLREARPCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPH3</accession>
    <name>A0A398CPH3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03219">
        <property type="protein sequence ID" value="RIE03219"/>
        <property type="gene ID" value="D3H35_20170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="201" mass="23263" checksum="5B6F955ECC963D89" modified="2018-12-05" version="1">MILIAREKTNPLERLKWAKNGLKLLDKAVAAAPNDSRIRYLRGKSSYRLPEKHFQRTRTVIEDYSFLINQELLQEGHLGAMGVDYSKLTYDLGEAYHRIGRNEDTVRCWTKLEQQTEDPELRQLLRQKLQSLEGKPAIEHIQGNESLKSILLEKAAHATGHLLLKLAKNGMIKVALPMVPKKENERKKEARSKRHKKNKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPI8</accession>
    <name>A0A398CPI8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DeoR/GlpR transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_12755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000038">
        <property type="protein sequence ID" value="RIE03239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03239">
        <property type="protein sequence ID" value="RIE03239"/>
        <property type="gene ID" value="D3H35_12755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="39"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="291" mass="32467" checksum="3D95C40A2EF84504" modified="2018-12-05" version="1">MLSVYCKRFENFSNMVLCRFIGGEHMDTLQEKAKYGLIPVERRKQIVAYVMKHESAQVKELAELFDEVSEATIRRDLELLATEGKLTRTHGGAASISTRTAFEQLYLDKCAMAVDEKRRIAKAAADLVENGDSIILDSGSTTIEIAKQLVNHTKLTIITNDLYIASTVAFHPSTQVMVTGGMKREDVNVLIGNITETFFRSIRVDKTFLSADAVDIHFGVSNTTFVEQNIKRLMLEAAKQVALVCDHTKFGNTALAKVCRLDELEHIITDEGISPSLREEMERLGLPVIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPL6</accession>
    <name>A0A398CPL6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_18495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02668">
        <property type="protein sequence ID" value="RIE02668"/>
        <property type="gene ID" value="D3H35_18495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029348">
        <property type="entry name" value="NTF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041143">
        <property type="entry name" value="YgxA_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18576">
        <property type="entry name" value="HTH_52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14540">
        <property type="entry name" value="NTF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTF-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_52" evidence="2">
        <location>
            <begin position="226"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="294" mass="33993" checksum="63E5C1731D370CEC" modified="2018-12-05" version="1">MDKKHLPYTDLFRDDENTVALLLITNPFSFQTLIDGMDKLVLVICKTAPAELETEHWMVQDERVQVRRITPERLERWVVGGDHRSVIPWLVGGEILYDRDGYLKDLQARLNDWPALLREQKLLCEFSRFIRTYLQANQDLKDGQILDAYSNILDSLHCWAHIALVEKGMHPELTVWEQMRRVNPGIYKLYEELTTSVETVEKRVQLLLLACEFSVLTQMKSSCALILRVLSSRDEPWTVSALQLHPQLKGLPIDFSLLLQKLVMRGLVREIAQPNRERGAGILKLLYTAHHAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPM8</accession>
    <name>A0A398CPM8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_13690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01837">
        <property type="protein sequence ID" value="RIE01837"/>
        <property type="gene ID" value="D3H35_13690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006189">
        <property type="entry name" value="CHASE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042240">
        <property type="entry name" value="CHASE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03924">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01079">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50839">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="CHASE" evidence="6">
        <location>
            <begin position="124"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="8">
        <location>
            <begin position="374"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="7">
        <location>
            <begin position="516"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="305"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="769" mass="87230" checksum="DC32AC4898D3834F" modified="2018-12-05" version="1">MNLWSQDLKPRQTTSLSTWGILLLVFLFLGGLITGFAYLCKDRLAEEVYRDASAELTANASSLKLSIERRLLMSEGLKAFTYTELIHNDGSVDPVRFDSFASHFTLPQQGIRNLSIYPNGIARFIYPLQGNEKVLGLDLFAHSDPKVRLNAERTKELTRVTLLGPFELTQGGSGLLTRQSVFFHDRFWGFVSVVLDVPPILEEAGLKAEDKGIELAVRADGQVIFGNPKLFDDASRLRETVSLTEGAWEMAAVPKSERLESISSKVRLIVLFSTLSMLLLMFLLYVLLTQKTKLQKKVNERTVELVEANQHIEATYEELLAVEEELREQYQVLEGKEQSLRHMAYHDLVTGLHNRTFFNERLEDQISAAKRSHRSMALLFLDLDQFKLVNDTLGHAFGDLLLNEVGKRLSEELTGEETVSRIGGDEFTIVMPNVCNPDEARQVAERVVGLFQQPFLLHDSEYFITSSIGIALYPEHGEDAATLTKNADKAMYRAKDEGKNNYKFYDSNRNSDVEEKMEIKNSLRRALERDEFDVHYQPQIQVETGQLIGMEALIRWHHPKRGTISPATFIPVAEETGMIVPMGEWILRKACAQNKAWQDAGLPPIRMAVNLSARQFGHNNLLESIRRILEETGLDPQYLELEITENLAMKDESLPTLTELRSMGITISIDDFGTQHSSLGYLKRLPVNRIKIDRSFIWGIGKDTRDEAIILAMLLVAQRLELSILAEGVETEEQFAFLQKHGCDDIQGFLFYRPQPADLIQKVLLDHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ33</accession>
    <name>A0A398CQ33_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02868">
        <property type="protein sequence ID" value="RIE02868"/>
        <property type="gene ID" value="D3H35_19790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1502" mass="166736" checksum="DB4D309912B212A4" modified="2018-12-05" version="1">MFDYMYVEQDPTARSKGIGRMWHLTAKNEVWYQTFEIPKTVKTPPKAEATPTIIKAEVKLQKLSENFTYVLDLAATIKDEAMYDGNGDRYDRAKYYYREDVTETVLKLDVSYPGGTKTTVGTWSSKNPADQVLLENGKQTARKRLVSVQLKKTNLKKDDVIQFTLTSMTYYDSDDNPKPRSQDSTDLKITLDEDVPPIIIPEIKIPEDPLPNPLICPANIPLHAFDIVSFPASDGTDLSRVEERNVYVDGVKIDDDTFFEGKYVFGDDADGLHRVDIQWKPKAKVTDPLDPGCVSSNPVYVHDTVPTAQFKLGGTFKENRKITVDENAASANDPYVLAAYPITSFTWTWEALDTALLADQRIKINGASHKEFLFKKSGEYALTLKVRNSLGRESEMYRQQFWVQEDFAPAVIMTPYASEVARGESVPLFYDAVSTDSDTVTKQHFNVYYDAAGDETYTQLIDSFDGLVTAYTPTFGKLGKYRIVATVDEDFGQETFPEFLTPADKRRSTAKFEFWINNYIPYSDIYTDIPTVRPQIDVFFLLDKNLEQSKIDYVKGNGVVINNQLRAEGIDPDVDAWDMHTYTYSQASTTYKDFGTSSPPATLAYCAGGYCGTLSLYDKQDYGGSRDFGSDKTETQTKTATGSCSNTQSVTYNSSGVGTVSWSGSCPGSQSYSDGDGYSGTLSRLGTSPSSGCGSSGTPNGACSTTFSTSYSGTVSRTVVVHIYDWRHVAEWRGYYSGTIYKDVRQSLTNPYARTASDKYLIYLSDSVINEPVEFESAKALSDAKVILVGASAMKSQTAYEAFIENNGQSIERIIEEIVEYIASRSPPTASQLVLTNETFHLLATDADPENDPIVKRETMYVQNENYYDNPMGHVGYALSEGDSPIWSEEYLRTSLPFTGEYTIHRRIKDLPSSEPQLANYSYYSNESKTVILVNRKPVAQAKLDWTYDDGCACYQTSWIDQSFDLDHSVSDPVAKGIVDRKIRYQAVGGEWYYRIPDFLLPGSYSLEYIVKDMEGNWSDPFKLSFVLEAAPPPQLGAGLKSEDAAFTPAGGVPASESLRAYELWTRYPYQVNLLFQMTPAGNFINKTVPYYTGSKTGSDIDWNDVVTTVPATTPDGSYIYRITAKGSNGKTTFREFAVKVSTPIQLVPFIKAEDGSGLSDTIVVGYPAKLEADTTEYASQVTVVAFKGTSYQKSLTLSGNVLSTAGTGAKKWESVFTPTGAIPDGSYTFEWTARTPNGNVETKSILMKVISNTPPFGDFQMFTYNSSNSSMPTFEGDTLHIRSIGIGDNERDSLTVRYEAFDPSGTRRLNDIRAMTYPYSSAGPDFILPGDGSAVGTWTVKQTISDGKAVPVVRMKTLTVYALGIQGYVKHTEEWEANRIRHNAKHPANQRPAEWFWAGEAFVLEAVATDTGVSGTTPISVTAKASQELAGILTAFPPSQKKVWQGLLRSDPSGFKLIDLEDGRYSFVFTVTYSNGITRKSTVTINVKDTIDQYVQVHRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQB3</accession>
    <name>A0A398CQB3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_04255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04703">
        <property type="protein sequence ID" value="RIE04703"/>
        <property type="gene ID" value="D3H35_04255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="303" mass="33498" checksum="3361BE01CF91385E" modified="2018-12-05" version="1">MEFRQLLYAIQIAAERNFSRAAEKLHIAQPSLSQQLSKLEKELGVLLFKRSTNSVEMTYAGSVFVDKAQQIVDMTEQLRREMEDIADLRKGRLVVGSLPTTGAQVLPHVLPAFRAAYPEIEVALIEESTKKLEQLTASGGTDVSLLSLPLEEPALAYEPILDEEICLAVPPDHPLARRHAEGSPSAVAVSDLRSEPFVLLKRGQGFRYIAYNICRQAGFEPRTVFESTNIETVQALVGAGMGISFVPRMIARKNGAEGSPVYLPLEGRPTRTLVIAYRKGRYLSNAAEAFISTFLETIERVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQC0</accession>
    <name>A0A398CQC0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_04010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04662">
        <property type="protein sequence ID" value="RIE04662"/>
        <property type="gene ID" value="D3H35_04010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="22"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="125"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="199" mass="23112" checksum="2495432C4D59C338" modified="2018-12-05" version="1">MLTDSQLIREIKDGNVELYSTLMSRYQKKILSFVFHMLKSAKLEIMAEDVCSETFYKAYRSLSSFREVDASFSTWLYTIARNTVLSELRKQKTSHLSLDDSTYIPAAPMEAAPEQRLLRNEKVLMVREAINSLPEKQRSALILREYDGMDYQEIANILGQTVSSVKSLLFRARASVKTQLESYFTEPSMMKEYEEMKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQQ5</accession>
    <name>A0A398CQQ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04873">
        <property type="protein sequence ID" value="RIE04873"/>
        <property type="gene ID" value="D3H35_05260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="145" mass="15889" checksum="1B63440C590C5BF5" modified="2018-12-05" version="1">MKIVVIGASGGTGRRVVSNALDLGHNVVAYVRQPDALQPKSGLDIVGGQLHEITKLQKAIEGADAVLCCLGPKVSLKGFLFPQSLMQTNIPYIIQAMKQAKVERLVLLSAYGIGIHQNTIRKNPELHNHFLKHSTTKAYRPRKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRD3</accession>
    <name>A0A398CRD3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_16880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02387">
        <property type="protein sequence ID" value="RIE02387"/>
        <property type="gene ID" value="D3H35_16880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="66"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="498"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="601" mass="67837" checksum="268DAC0C065B68CD" modified="2018-12-05" version="1">MEFGTSFEGFACCTGTRAESCSAMRTRGELSSKFGCPLPSSSRSAGMSRYCKKRRMIRKGGNVLLTMLVVDDEIYALKGITQGIDWSDLPISVILEAENVDQAKRKLQENKVDLVISDIEMPGANGIELLRYIREAAPATLTVFLTGHARFEYAQEALQYGCFDYVLKPVDHDVLKEIVKRAIEEIERRQERQAFEEMLEKYRRHWKNQLPILVEKFWQEVLAGRGPAGQDRLDREFAMYDIPLSAGDRVLPVLLSIEQWDVELDARDESIMEYAVRKAAAEIILGDRKGAVLQDRNDVNLVLVYLPDGALADRDALKTACLQYVRASNDYFHCRVSCYVGDTVRIGEIAGSVERLSQLERANISNPQTVVDGLESGEALGGSAAGPSLPSFMEWGILLDNGSIDELVLAVNETLRRFQEESVSRETLELFYFGFVHMLFQAAHRKGVSIYDALAVQEMNDGQFARTPLHMQAWAVKMVQKAGQAFQDRHRDASAVIAKIQSFIQDNIHKELGRDDIAGAVYRNPAYLSRMFRKETGLSLTDYIAQAKIERAKRLLIDTNDKVSHIAEGIGYTHFSYFAKLFKKMTGMTPQDYRKKHQTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRL6</accession>
    <name>A0A398CRL6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RHS repeat-associated core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_02095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05183">
        <property type="protein sequence ID" value="RIE05183"/>
        <property type="gene ID" value="D3H35_02095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="286" mass="32606" checksum="26DD0CC55155960F" modified="2018-12-05" version="1">MLTDDQLERNGCEYLVFPNLFPLIGGMADIAVLFESGRRHIANYKFEACTDSVYATNYSYNGDGYRTSVVDAVYGTTKFYWSGDQIELEADKSGQMRARNVYGLERIGHVIGSGSTSYLPNEANTYYYLYDGHGDTRALLDVSGEIASGYRYDPWGRVTSATGTLDNPYLYAGEYTDVTGLQYLRSRYYNPAIGRFLTEDTYPGQLSNPLTMNLYVYVGNNPMVYTDPSGHVWKAWHDGPEWLPFSQKYIDNYENNLKQGLDWIDRKNKALGSTARVQIRSRRRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRU4</accession>
    <name>A0A398CRU4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spore gernimation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_01775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05273">
        <property type="protein sequence ID" value="RIE05273"/>
        <property type="gene ID" value="D3H35_01775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004761">
        <property type="entry name" value="Spore_GerAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34975">
        <property type="entry name" value="PTHR34975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03845">
        <property type="entry name" value="Spore_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00912">
        <property type="entry name" value="2A0309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="366" mass="40426" checksum="9ED2F2E63A3521BD" modified="2018-12-05" version="1">MSEQSKLSAHQLMVISVFFTIGSAILVIPAVMAHFAKQDAWIAAVIGVGAGMLSVWIITAVGVQFPKRTLIEIIEAALGRWPGKIISLWLFGTIFLCSPSVVLFVLGNFMVTQMMPETPVQSLQILFALIVVMGARLGLETLARAAELLFPFFAVLYVLLVVSASPEIKIANLQPLFETDLASLGSASLFFMCTLNMPIVVLLMIFPSMSPPLRARKAIFTGSLIGSLAMAVIVLVTILVFGPDFTAGHFFPSYELAQKIRIAGFFQRFEVIIAFLWILSLYFRLTLYIYCTATAAAQIFRLKDHRPLILPIGMLLVVMPTLIFPNIAYEQTYELKTWIPYTLSVGLLLPLLLLIVHGLRKALVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRX0</accession>
    <name>A0A398CRX0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000009">
        <property type="protein sequence ID" value="RIE05322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05322">
        <property type="protein sequence ID" value="RIE05322"/>
        <property type="gene ID" value="D3H35_01055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="97" mass="10844" checksum="F7F13E78F74ED8B0" modified="2018-12-05" version="1" fragment="single">FSDAAHVKENLVPYSERLDGAAGLRISERRSIEGDFVVKRIEITPETGEPRRYEERVRLIGLERFRSMAKQTGLTIEAVRGVMKARATMSGSPPVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRY4</accession>
    <name>A0A398CRY4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02557">
        <property type="protein sequence ID" value="RIE02557"/>
        <property type="gene ID" value="D3H35_17880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="120" mass="13720" checksum="B26D6F7B2B29E824" modified="2018-12-05" version="1">MLGAKTTGQLIPDTLDKMSIVMGMYDVKESEYYLTKENLTAIFDRYPKLKGKEFGNFIERTQLNEMPYAFALMLIGPNAFGGKEEAQEPLVREEPGYGHGDWNTKWFPKRTNSSRKIGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS28</accession>
    <name>A0A398CS28_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000006">
        <property type="protein sequence ID" value="RIE05405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05405">
        <property type="protein sequence ID" value="RIE05405"/>
        <property type="gene ID" value="D3H35_00520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="68" mass="7751" checksum="C7AEE885085DDDB1" modified="2018-12-05" version="1">MLSMIECRAPEDIRAWNERKLAMEQQLEQRFEELAFIVRIREIAAVSPSFAKLGKASIGPKIAMRATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSG4</accession>
    <name>A0A398CSG4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02737">
        <property type="protein sequence ID" value="RIE02737"/>
        <property type="gene ID" value="D3H35_19015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="361" mass="40147" checksum="7BEECF5B5C46C557" modified="2018-12-05" version="1">MVIKQPLTRLVPAFWAIALTIVFADLILARVVPGAPEDRTFVYAVLFDFMLVVPALYWFLMVKKSGKKRSRVLLIPGIGAIVAWLALPAAARAAVWQAAAPMEAFIIAFEAAIIGYEIRLVYRAIRQFRTEKRKTADTAEALRTSIVHAAGTGKIASVMLHDISMVYFLIFSWRRKRPASQTAEAGFFTYHRGNQWIYPAVITKIVLFETVGLHLLVQMWSPVAAWIVTALDAWLIALLWADYRASALQPVKVEEDVLKLRYGLRIQADVPLASIASIAKRGEAAMDEKKSKDEIGPLYGSGNVRIELKAPIRVEGLLFLPREATIIDLTLDEPDAFVRTMNGRLHAEDGLPASPISNPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CST6</accession>
    <name>A0A398CST6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_06850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04319">
        <property type="protein sequence ID" value="RIE04319"/>
        <property type="gene ID" value="D3H35_06850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017210988" evidence="2">
        <location>
            <begin position="28"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="516" mass="58136" checksum="5AB330C2722B0A27" modified="2018-12-05" version="1">MNHIKGKKIRRWAVAGTALTMLVPLLAACSTDKTDDPKNRHTLRIGTMYGSKQDESYFRQQFTDIFEYTHDGIDIEVVPAIDYNEMQFDNMNGKEQTQQPDPLEKVKAIMTGSNPVDVMIFDFSLLGQLVGENLLKQLDTQMKEDEINASDFAATVIDGIKEEGNGNIYALTPTFMPSALFYNKKLFAKANVTPPHDGMNWDEVFNLAKQMSTGDGKDRVFGFSFSSYGGGENYWDIQNFLAPLKLRMYDENAEKMMVNSPKWTNMWKTVYGLYKDHIIPHQDDFVYDQPTDGKYNPFQGQMFLNGRVAMTIGDYSYISQIQQLNDNADKLKMEKLDWDVVTIPFHTEAANVGANINLSSLAGINTKAANSDDAWEFVKFINSEKWAQLKSRSMYEMPSRKAFIKAREGMTYNVEAFTKLKPFSNSQSQKDLEISRTKPNIRFISELASQAYNAVVSGKLSVEQALKELETRGNDLLQKLKTDPNGPMDDFYNQPPIGGNGDGSSGGGGIVRPMID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTD2</accession>
    <name>A0A398CTD2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP2_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_00595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000006">
        <property type="protein sequence ID" value="RIE05420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05420">
        <property type="protein sequence ID" value="RIE05420"/>
        <property type="gene ID" value="D3H35_00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025559">
        <property type="entry name" value="Eis_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13530">
        <property type="entry name" value="SCP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2_2" evidence="2">
        <location>
            <begin position="27"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="94" mass="10122" checksum="7035DB9C3D7BFF56" modified="2018-12-05" version="1">MERRLVPVDDSRERTIGLGRADRDGGSGNSSAACDIQTWTAMLAGGRRPAAFASVGRLKAEEEALAIMERRIPAARLIWRISSDQTAIGSSSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTX3</accession>
    <name>A0A398CTX3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="6">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">nadD</name>
        <name evidence="8" type="ORF">D3H35_05895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NadD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04158">
        <property type="protein sequence ID" value="RIE04158"/>
        <property type="gene ID" value="D3H35_05895"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="6"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="195" mass="21953" checksum="1836B08103191F37" modified="2018-12-05" version="1">MRRIGLLGGTFDPVHYGHLLAAESAREAAKLDEVWFIPTFVPPHKPKPGAGAEDRVAMLQTAIALCPEFRVEPIELGRKETSYTIETVVTLQELHPDCQFYWIVGSDMVKDLPNWRKVEELAERIAFIGLERPGEPLGDTELPVFIRRKLHRASMPPIGVSSSEIRRRVKDGGSIRFMVPGEVAEHIRRCGLYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTX8</accession>
    <name>A0A398CTX8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminodeoxyfutalosine synthase</fullName>
            <shortName evidence="6">AFL synthase</shortName>
            <shortName evidence="6">Aminofutalosine synthase</shortName>
            <ecNumber evidence="6">2.5.1.120</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Menaquinone biosynthetic enzyme MqnE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">mqnE</name>
        <name evidence="8" type="ORF">D3H35_19225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine = 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:33075"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64286"/>
            <dbReference type="ChEBI" id="CHEBI:76981"/>
            <dbReference type="EC" id="2.5.1.120"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. MqnE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.120" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02771">
        <property type="protein sequence ID" value="RIE02771"/>
        <property type="gene ID" value="D3H35_19225"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102573">
        <property type="term" value="F:aminodeoxyfutalosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00993">
        <property type="entry name" value="MqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022432">
        <property type="entry name" value="MqnE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03700">
        <property type="entry name" value="mena_SCO4494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="58"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="367" mass="41596" checksum="E9EA5B1BD13ACB27" modified="2018-12-05" version="1">MTLVTSNTERRMADIADKVRNGERLSFEDGVFLYRSDDLLTIGQLANEVNLRKNGKKVYFIENMSLYFTNVCEAHCAFCNFRKNPEDEGAYTLSPEEMIAYVDQHIHPGVREFHIVGGHNVNVPFDYYVESIRALKIKYPQVTIKAYTAAEIDFFSRISGLGYAEVLKTLIDAGLETLTGGGAEILSDEYRKKMRVDKASLDQYLEVHRTAHRLGLRTHTTMLYGSVESIEQRVQHMIHIRELQDETNGFQVFIPLSMQPISPKASIRRRNSAYDDLKAIAISRLMLDNVQHIKAYFINIGTQLTQIALTMGASDAHGTIVRERISHAAGALTPAGITREDLIWLIKGAGRIPVERDTFYNEVQTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUI8</accession>
    <name>A0A398CUI8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04308">
        <property type="protein sequence ID" value="RIE04308"/>
        <property type="gene ID" value="D3H35_06770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="472" mass="53724" checksum="B1A9FE987BC5E8D0" modified="2018-12-05" version="1">MKNIIKNFSYSFSANIITLIISLLSIIIIPKIIGVEEYGYWQIYMFYVSYLGFLYFGHADGVYLKYGGKEYKNLDKPLFVSQFWLLIAFEILISAVFIIYSLFFVDNKDRAFILLIVSINIVIILPKALLQFVLLATNRINENARSIMLERILYGVIVIALIVIGVRDYKVLVSVDLFAKIISFMVTIYYCKEIVRGKTASLKMGLLEAFDNVKVGINLMFSNIASRSIIGIVRFGIEKNWDVITFGKISLTLSVSNMLMLFINAVGTVLYPVLRTTAKEKLPIIYTQMRNALIISFLGMVVVYYPASSILSSWLPKYSESLIYMALLFPICLYESKMSMLVITYFNTLRKEKVMLKINLVILALAVITTCISIYLFDSLTLTVLSITILLAIRCVISEVIISKILKINLMSDIILELVMTIAFIVFAWYVGGTGGMACYLLLYLVYAYLKRKDIKELVLFVLSILKRRATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUP6</accession>
    <name>A0A398CUP6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4062 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_20665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03011">
        <property type="protein sequence ID" value="RIE03011"/>
        <property type="gene ID" value="D3H35_20665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025139">
        <property type="entry name" value="DUF4062"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13271">
        <property type="entry name" value="DUF4062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4062" evidence="2">
        <location>
            <begin position="19"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1161"/>
            <end position="1196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1424" mass="162790" checksum="1CC93022E69888A9" modified="2018-12-05" version="1">MTNFAASTYHQPRSVRSIRVFISSTFLDMSEERDELVQKVFPELRSLCAKRGVVWSEVDLRWGIREEQVDKGLVLPLCLKEIDNCQPFFIGMLGERYGSISRHEIPQELLRDYPEIEPYLGRSITEIEIRHALQRPQESSHSYFYFRDPSFVTRTREDKRHLYEERISPREELTLGKAQAESLAAERKALLEGLKQDIRSSGAQCREGFADSRQLGQWVLEDFTKLIDRLYPQDRPADAAERERYEHEIHAMNTTGDVYIRNKDYFEGLNDRVLTQRRSALVHGISGSGKSSLLSHWIKSVEASEPDIHVVKHYVGLTKTSASCIGTVQRLIGELNARFDMNVPVPLDVKDLRDAFFQCLRAVPETETTIVMIDAINQFEDADDHEFFSWLPTELGSHIRFVLSSTRSGPEELEDWESMEVGLLGEEDKRHLLGQFLSVRYGKELEPRHIEQIVAAPQTENPLYLRALLEEIRLIGDRGSFDKQLGDYLLAPTPDLLYDQILARYERVYGDGSGRQLVKEALSLIGVSRSGLLEQELRDLLGKEGEQLSSSFWSPFMVAVEPYLTNRSAPLRIYHTYMKQAIERRYLNESASAAARRKIARYFDSDPRATDMERKLDELPWQLIRLKEWGRLKELYKNHDFLLAAWKNDPYDVKIHLTTLENETVSWKKAGTPIRLTEMYSDVFNRPETYPLTLISLLAQWMEARSPDPALKLNVFLENVYRETGNTRMLQQSLYRQAEILRNRGRIEKAAVKVAAQLELCRDNGHLDGLQAGHGLMADILIQKGQYPGAEKHLGELERLLAAMPTFEGRRLYLSKQAKLNRMRFRLDEADEQLSELRSLCIAAGNKDALQECLGEQMLLLKEKGACGIPGALEEALALVEERKQICDQFGNQYGLMVSLAYESDIYCKLGDFNKAKYSEKHQKALNREFRSRHVEQLICGVQARVEFYGAGKIKKEKKGTHYNQMKSNIALALLKDKETICKELGLFEELQDAYDMQGEVLYRGFGTQYVKEAIKKRELQEGICRDIGYTMGLQRSLHGKGHVYLSISDFDSAMKAFGEQLALLRPFQLPHYKQTALGSMARARIGLYSVKKDRELLHRALEDLQEQESLTRDIANEGGILFSIDLQAETYRHLGDRTNALQTMERYILAAEQFGREEEKLKGEKKRQKWTTEFTAGESAEKSANEAAPASEGATLTEPELAMLAKIGGAGASRERHLFDLSQPLPISQKIMTRLHAIGFVVRERIIYDSRKCNIYRLSEKGAAYYEMAFGQAPVPAELDGLQGSPFGMEQAFFEAELFDSLARVGGSAGSPRGLVPIEIEGGKSWLYVHRHGRRDEEALALFEEAHGFDGNRSFYLAADDEELLYGTVMPLFYRWLLRKYEHWSLIEGEYIVHFVPPAFVLSFSQDMRPHTVKVSAAKLKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUU9</accession>
    <name>A0A398CUU9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04368">
        <property type="protein sequence ID" value="RIE04368"/>
        <property type="gene ID" value="D3H35_07185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="123" mass="14022" checksum="7B64E5E394DAA7EB" modified="2018-12-05" version="1">MSELIDDSRPIFMQIAERIENDIIDGTLSEEAQVPSTNQFASFYQINPATAAKGVNLLVDQGVLYKKRGIGMFVASGTRELLIEKRKTQFYEQYVVSMIREAEKLGITREQLTWMIQKGDETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVC3</accession>
    <name>A0A398CVC3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03857">
        <property type="protein sequence ID" value="RIE03857"/>
        <property type="gene ID" value="D3H35_09920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="66" mass="6984" checksum="BC03F6F23BE957CC" modified="2018-12-05" version="1">MVHRPPRKRTNVIDLMALTSLERLAGGGAPQYGAVQVLTEKSAQVSKARGNKRPAASEAGDRSDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVF0</accession>
    <name>A0A398CVF0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_01810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05279">
        <property type="protein sequence ID" value="RIE05279"/>
        <property type="gene ID" value="D3H35_01810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017259057" description="Amidohydro-rel domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydro-rel" evidence="4">
        <location>
            <begin position="84"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="379" mass="41836" checksum="78935695F8AC1616" modified="2018-12-05" version="1">MIGTKKLGKTALIAAAGLVTAAAIMIFTKPDETPPAATAQASAESGEPTSSPSALPSAPAAETPSPISVKEALAAKYADLGLIDVHNHDAPRYADSLRTWDRYHVGKVVLFGDISEPSAMLTDAMSWEAYRSYPDRIYPFFSGFDMFKKEGLQTVRDQLEKGYLGIGETVAASTLSPVLQNVIWKAEDPMDGNLPDVYALCAEYNVPILLHIDPPNGTPVEKLKEALDRYPDTKIIFAHANAYQGAVAIDDLLEEHSNLYIDFFAGFTSYSISSPYRTEAYIDVIERYPDRFFLSTDGAFDMTYDEAIPAMYETLEMLKPETRKKVASGNFQKIIDAEKPTKTQLQRYKELGGTEQDVAKLTALSRHEMNKLLFKLGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVX8</accession>
    <name>A0A398CVX8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic lactone autoinducer peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04037">
        <property type="protein sequence ID" value="RIE04037"/>
        <property type="gene ID" value="D3H35_08780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009229">
        <property type="entry name" value="AgrD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04223">
        <property type="entry name" value="quorum_AgrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="40" mass="4514" checksum="548AA2E345697164" modified="2018-12-05" version="1">MKKKMIIAVSKVLALFAVMFVSTACVWIMHRPPVPAELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWD8</accession>
    <name>A0A398CWD8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_10800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03531">
        <property type="protein sequence ID" value="RIE03531"/>
        <property type="gene ID" value="D3H35_10800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017295797" evidence="2">
        <location>
            <begin position="35"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1264"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1269"/>
            <end position="1283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1305" mass="140882" checksum="5635479625B273D4" modified="2018-12-05" version="1">MLKEWYSNSRLSKLILAFGLIAAQLLSFSPGSRANTASELKTTVQASSQAAKPGDEVALKVLVDSGISRSIHIQLQVVGPNGTAVYQQWAYDKPVAAGGVNEYPFKWTVPEGLPAGNYAVSVGIFGASWDAMYSWDSGLAVIQIQSGATLPGFTAEAAVPPSVEAGSQATIKATLVSDQATAGKVALAIHDSSNALVHEQSFAGVTFAANTATSVSTVWAVPEDAVSGAYRIELTVVGADGSTVYYRNASFGSIQVAQSDPGAGATFQTRAVMDSTTAESGEKFDFSAEIKADRNASVLVDVIVKNPYTNEPVLQAVFERQALTAGGILSIPISWNVPADAPSGRYPIEIGIFGNGWQGPYHWNANAGYVQVGGGSVPPIEFVANTAVAQSVVEAGSPQSFAVTATGSADATAIVQVKVLDPQGLTVFQREFPNERFIARQARSFNASWPVPSTAALGTYSVETGIYSADRSHTYYWNSSAVQFAVEAGTPPPTQPDNGATAVWTTSVVAAETAEAGYPTTVTANVASDDYAKALVDVEIYDEHGSKVYQAVFDHQYFQPNAAKSFPVTWSIPASQPRGQYSVSIGVFPESWGTAWKHHWNGGATDFDVNWGIVPDIAHESNADLEAIVPGQKQTIRTRLTSSETLPATVRLELFDSAGSRVASAEYMADEFVQGVANDYSMDWTPDANSVNGTYKLKVSVAKADGVRVFYSNPEAVQFSLSGGIDLTYSLSAATEQEEVSAGQTLNVSAFVGSTVPSVVSMKINFIDVLTGKIVHSESAYNKPIVIDQETAVDIDWTLPKWIRMNEEKVRSGAEPLIQYILDGDYRVDIELYNADMSQRIATHNGAAAFKVVSPDDAPAPQPAEAPALPDIMKLGVFATNNDDHGITGWMPETGLPWNFAYRYLNGGANNQEGWTSWDPYFVGSWQGAYAYDYAKKATDRGYTPVFTFYQMLQSISGDCLNCDETKDDIITLNDPYAMRAYLEEFKLLMQLIGTGEYNGKPGIGKTAIVHVDPDLAGYAQQAVLDNDRCFGQCTGKGNNPAFLKAAVASTRMPELADLPNTYQGYNWALLRLRDLYAPNVIMAPHVNSWGTLIDVGRDTNPNLDVTALGKLAGEFANLSGAKVVPAGIKPYEYIFNDIDDDDAGGSRGYWLDRTNLTLPNFHRWEQFVKAAVETTGKKAMIWQIPVGNQVYRAMDNTPGHYQDNKAEYFFEHMQELVDIGIVGLMFGHGQPGSTSHYNRMDDNGGAPASADYYNPDPLTFSDGWGDGSVHTNDKEADSTDDDGGYLRMQATEYYKHPIPVSNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWJ5</accession>
    <name>A0A398CWJ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_12015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03394">
        <property type="protein sequence ID" value="RIE03394"/>
        <property type="gene ID" value="D3H35_12015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12727">
        <property type="entry name" value="PBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="2">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="1">
        <location>
            <begin position="92"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="310" mass="33775" checksum="8FD6486293D683C3" modified="2018-12-05" version="1">MSQDMSYTTEEIAKLLKISKLTVYDLIKKGELRSYRVGKQMRVDASDLEQYKLRAKGGALPAAPRPISQAASGGPVRQLVITGQDISLDLLAKHLEKQASDVRPLRSFVGSMESLVALYRGEADIVSAHLIDGDTGEYNVPYVSRLLTGHSYLIVNLLIRTAGFYVAPGNPRGIQGFQDLAKPGLRIVNREKGSGARVLLDEKLRLQRISPSVLDGYEQEESNHMAVAGKVASGAADVGIGTEKAALIVGKVDFIPLVQERVDLVMLKTPRNLEWIEAVLSILRSEAFLAELGAIYGYDLSRTGQIVAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWN5</accession>
    <name>A0A398CWN5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000034">
        <property type="protein sequence ID" value="RIE03621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03621">
        <property type="protein sequence ID" value="RIE03621"/>
        <property type="gene ID" value="D3H35_10625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="173" mass="20070" checksum="D43CE0EEEF55FF9C" modified="2018-12-05" version="1">MQCVPCEVLDHINMKVLELLVGTGDERLNELAEAYQDKLSQLVQETIGSDIFKRISERTAEASYLGELVHSHVLAAQAHALSEKISETQRELAADTSRIEATKQELQKRYEDAERIRQELERRSDDRELLDRKELLEKEISELKRKARDLEKKSETSKKNVTALRILKKRKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYD4</accession>
    <name>A0A398CYD4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IDEAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04004">
        <property type="protein sequence ID" value="RIE04004"/>
        <property type="gene ID" value="D3H35_08600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014957">
        <property type="entry name" value="IDEAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027393">
        <property type="entry name" value="Virus_scaffolding_prot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08858">
        <property type="entry name" value="IDEAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IDEAL" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="122" mass="13354" checksum="23BEC42ABCA5DC3C" modified="2018-12-05" version="1">MKFEIGDWVTATSTEDELIQGFIDSIDVVQGTLGVRVIASDHEFAVGKAIIVRNQEAKIMPLSSLDSEEDLMSLIDIALSTKDETWFMELTEKLIALQRGSNSNGQRSRTAAAVRNRLGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYN8</accession>
    <name>A0A398CYN8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04114">
        <property type="protein sequence ID" value="RIE04114"/>
        <property type="gene ID" value="D3H35_09235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="123" mass="14300" checksum="214D38D456914E27" modified="2018-12-05" version="1">MLESLERTSYRNYEIVVIDNGSDDAETIRYLGSLRHRVLAIPNPNGRFNYAYIHNEAVKRIDSEYVLFLNNDTVALKPEWLSQMVGYAHRKEQARRARLLFPDGRIQHAGITHGFYKGMQAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYQ0</accession>
    <name>A0A398CYQ0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04957">
        <property type="protein sequence ID" value="RIE04957"/>
        <property type="gene ID" value="D3H35_03200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="67" mass="7793" checksum="1EF5E09A83FA11D5" modified="2018-12-05" version="1">MAYVIYTSGSTGKPKGVMIEHDNVVRLFFNDRTPFQFSYKDTWTLFHSFCFDFLFGKCMVPFCMAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0B4</accession>
    <name>A0A398D0B4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation protein YtfJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ytfJ</name>
        <name evidence="2" type="ORF">D3H35_03670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04604">
        <property type="protein sequence ID" value="RIE04604"/>
        <property type="gene ID" value="D3H35_03670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014229">
        <property type="entry name" value="Spore_YtfJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39162">
        <property type="entry name" value="PTHR39162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09579">
        <property type="entry name" value="Spore_YtfJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021377">
        <property type="entry name" value="YtfJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02874">
        <property type="entry name" value="spore_ytfJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="166" mass="17221" checksum="8C49C64069F88798" modified="2018-12-05" version="1">MSEHPIKGLMQTAMENIKDMVDVNTIVGEPVQTPDGSVIMPISKVGFGFAAGGSEFQPMDENGGGSAQHQSKSGDGNDSHHASVQLPFGGGSGGGVSITPIAFLVVGTQGVKVVPLDNQTHILEKLIDAAPHWVDKMKGIFQRGAEADSSESTLPAATHSSDNNVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D116</accession>
    <name>A0A398D116_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylneuraminate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04864">
        <property type="protein sequence ID" value="RIE04864"/>
        <property type="gene ID" value="D3H35_05210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="303" mass="33861" checksum="6A62A581576EC09E" modified="2018-12-05" version="1">MSSNRKKYVQLQGIIPALITPYEDDGRISDKRTRELVRHLISQGVAGFYLSGSTGEGFLQTVEERQSFLEIVMDEVKSEVPVIAHVGAMDTATAVVLTKHAYGAGATAVSAVTPFYYKHGSEQIKRHYIDIAEAADIPLIAYHFPDMTGSKQSADFYRELSAVDGIIGLKFTSMNTYEMQQIMDVCGEDFLVFNGPDESCLAGLAMGAFGAIGSTYNIMPAKFVEMHRLFRQGRIDEARAVQYEVNRVINELMKYDFIAFEREILRLQGFDTGLPRKPIQQLSDAQRADIRETAARFPFLNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1L1</accession>
    <name>A0A398D1L1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_00930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05381">
        <property type="protein sequence ID" value="RIE05381"/>
        <property type="gene ID" value="D3H35_00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02857">
        <property type="entry name" value="E_set_CDase_PDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004185">
        <property type="entry name" value="Glyco_hydro_13_lg-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02903">
        <property type="entry name" value="Alpha-amylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="136"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="585" mass="67076" checksum="B5FC5B23323D0211" modified="2018-12-05" version="1">MNLEAVYHRTKFNWSYAYDDRTLHIRIRTKKDDIKQIDLHCGDKYGWDRTNTVVPMTLWVSDALFDYWQATVQPKFRRLVYYFALNDGDRTVYMQEKGFFDDAPVIFHEGLFDFPFLNPADVHTPPAWVKKAVFYQIFPERFANGDPTNDPEGTEQWGGKPGLNNFFGGDLQGIIDHLEHLTSLGINAIYLNPVFEGTTNHKYDTKDYFKVDPHFGTNDKLKELVKACHERGIRVLLDAVFNHSGHTFEPFVDVMEKGASSAYADWFYVREWPLTVKDGVPTYDTFGFEPIMPKLNTANTEVKEYLLKVAKYWIEEVGVDGWRLDVANEVDHAFWREFRKTVKGVNPDAYILGEIMHEAVPWLLGDQFDAVMNYPFTKACLDFFAHDRIGANQLANRLAGQLTSYPSQVNEVAFNLLGSHDTARLLTLCEGRTERLKLATLFQFTFPGAPCIYYGDEIGMDGGHDPDCRKCMEWDPQKQNGDLLQFFKQTISLRHQYPALQDGALTFLQDQANDQNLIYERRDAQDRFVILINKSESSSVFRATIANEAWTDIVSGTPVTAEQGQLNFELPAFGYAILHARIGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D291</accession>
    <name>A0A398D291_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">map</name>
        <name evidence="5" type="ORF">D3H35_01505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05224">
        <property type="protein sequence ID" value="RIE05224"/>
        <property type="gene ID" value="D3H35_01505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="11"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="248" mass="27107" checksum="063D7EA0A58B850F" modified="2018-12-05" version="1">MIILKSPREIEEMKPASQIVADCYREVAKLIEPGITTREINDFVARHIIKLGGKQFTKGYNGFPAETCTSVNDVVAHGIPSNRVLMDGDLLKLDIVAEYGGWLGDSCWCYAVGNIRPEAQKLMKVTKECLDLGIARALPGGRLGDITSAIQQHAEANGFSVVRDLLAHGIGRSLHEEPNYEHIGAAGKGIRLKEGMVFTIEPMINEGTFRITIDDDQWTARSADGKLSAQYEHTIAVTPDGPLILTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CC22</accession>
    <name>A0A398CC22_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_26265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00706">
        <property type="protein sequence ID" value="RIE00706"/>
        <property type="gene ID" value="D3H35_26265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006061">
        <property type="entry name" value="SBP_1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01037">
        <property type="entry name" value="SBP_BACTERIAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017331915" evidence="4">
        <location>
            <begin position="32"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="430" mass="47061" checksum="2A11A948F5EA632D" modified="2018-12-05" version="1">MAKRWIAIAATAALVPTLLSACGSGNNNGNASPSGSASASESTKPVNITILQYAPEMTDAINKLAADYKKSHPNVTITATIHQDDYPTLLKSRINSGDIPDIFMTGAYNENKTYQDYVYDLTNEPFMKNIVDTALPGVTLDGKLTGFPLVLQAHSFVYNKKLFADAGITELPKTFAQLEDAAKKLQAKGVIPFANGYKEWWVLEQTFTQELASMGGDYPKTFEELADGTKKLSDIPEAMNIFKLLDLTTKYGNSKPLETDLNSQVALFAEGKAAIMHQGTWVEDSVRKLNPEIDMGFLAGPVGDDASKAGLMVDSNIVWRVNKDSKNLQEVLKFLDWMTTSDEGKSFIPVGTKQISTVKDAPFPDAQLSKETQTFLQSGVTYPWVKGYWPDGFEQKVGEILQKYVSGSASEKAVKAELDKTYKTLVNAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CC84</accession>
    <name>A0A398CC84_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_28605</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00383">
        <property type="protein sequence ID" value="RIE00383"/>
        <property type="gene ID" value="D3H35_28605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="8">
        <location>
            <begin position="51"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="6">
        <location>
            <begin position="222"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="7">
        <location>
            <begin position="338"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE00383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="557" mass="63517" checksum="CDB84153018CD836" modified="2018-12-05" version="1">MLRMMQDDNRPDWSNLNVLEKNTVAPRADLLPYGDWESALAQDRAASPHYESLNGIWRFQYAEAPELAPADFYEPGCEDAEWALLPVPGNWQMHGYGRPHYSSCPYPFPIDPPNVPALNPVGCYRTAFRLKDGWDARRIRLVFDGVDSSFHVWVNGLPVGYSQGSHNQSEFDITSYVRVGEDNLLAVRVYQWCDGSYLESQDKWRLSGIFRDVYLLSLPAITIEDAAVRTILAEGGASAELEWKLLLTQGIAGDYSSWRLRTVVLDAERAPVFDRYYDGSIQPAEEDGLRLAMSETILSPRTWSAEDPYLYTLLLTLYDAEEKIQEVKEIAVGFRDIVIREGQLLVNGVPIIIKGVNRNEFHPVNGYVTTLEEMVADIKLMKRHNINTVRLSHYPNDTRWLDLCDRYGLFAIDEADLETHGFHFIEDESYLSKHPDWKEAYVQRARKMVERDKNHPSVIMWSLGNESGYGPNHDAMAEWIREADPTRPIHYERAYEAAVVDVVSTMYPSVDMLVAEGKKSDPRPYLMVEFGHAMGNSVGNQKEYWEAVHQYPGCSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD16</accession>
    <name>A0A398CD16_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_21875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01076">
        <property type="protein sequence ID" value="RIE01076"/>
        <property type="gene ID" value="D3H35_21875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="129" mass="14693" checksum="C00D91C527CB65A6" modified="2018-12-05" version="1">MTIEEDNMDREIKNDEDAKKFVDQYDYTGVYQSDYIFGEQVDVYKDIIGEKHTPEEMDQIIALAESDVEREYSNAIERDESNAIAANAIVTPHTVNNDASNPATLIVISIILAALVLLFVAPARRRWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEA8</accession>
    <name>A0A398CEA8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Theronine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_29585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00192">
        <property type="protein sequence ID" value="RIE00192"/>
        <property type="gene ID" value="D3H35_29585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="4">
        <location>
            <begin position="10"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="345" mass="37131" checksum="CE9AB400489EDDF6" modified="2018-12-05" version="1">MKAVVLKGVKQMETLDVPVHELQADEVMIEVICCGICGTDQHIYHGNPGSAQVQPPVILGHELAGVITKIGQGVAGFNIGDRVSIDPNLYCRQCSYCRSGREHLCDHLQAIGVTRDGGMGQFCAVPARNCYLIPDSMSFEEAALVEPLGCVLHGFRKLQFSPLSKVLIIGGGFIGQLFTQLAKREHVSRIVVSEPVESKYSLLFGLGADEVVQPLSAGTADSIGSGYDVVIECVGRKESMELACAAARKGGQVLLFGVSSPKTSISINPFEVFSKELVIRGSFINPCTHEEAISLIDQGVVQVQSLISHRFDPDEVPAAMELYPTLQVSKGVIKYGGTERAVWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEI0</accession>
    <name>A0A398CEI0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyrophosphatase PpaX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ppaX</name>
        <name evidence="1" type="ORF">D3H35_21500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01030">
        <property type="protein sequence ID" value="RIE01030"/>
        <property type="gene ID" value="D3H35_21500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="220" mass="24107" checksum="0AD574AB42984D71" modified="2018-12-05" version="1">MSLKKKITTVLFDLDGTIIDTNELIIQSFLHALKGIVPPDFDREHIIPSMGMPLSVQLQLFSGRDDVEELTRLYREYNHGRHDEMVTLFKGVAEVVPQLHQAGIKLGVVTTKMRQTSERALKLFGIYEYMGTIVALDDVEHPKPHPEPVLKAIEALGALPEETIMVGDSPVDIESARRAGAVAVGVAWSLKGEAKLRESGADHVVLDMDELVAMCGIGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEP6</accession>
    <name>A0A398CEP6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_22550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01183">
        <property type="protein sequence ID" value="RIE01183"/>
        <property type="gene ID" value="D3H35_22550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="11"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="476" mass="51794" checksum="62EBABB272A0DA46" modified="2018-12-05" version="1">MKAFDIKKHSVLLAILIGAFSLVLTNSAFNILLPSFVRMYGISTAFGGWIIILYILAMTITMPLTSVVVDRLGRKNTYILGLGLYGLFSIVGGLFCQYVQVVLLVRVMHGIAAGLMIPLSLVLLFDYYGKEVRGRVVGAWGILLMIAPAIGPTLGGAIVQFGRVELLFWINVPFAFFSFLLCCTQIKRYPPAYRKTIHLQGIALMVLSIASLSLGIQMVSNPTVPRWVPCLLLALGAAALVRFIQKENAKEEPLIRYKLLRRNPVFTVSLLISAIQDAVMFGVIFVLPLIFQEVFHLSPSVTGAMFIPTALFTSLFVWIGGSLVDSGKSLKFIAYGIGFIAVSVLAFAFVPKEVSFLVLLLLMALRGIGNGLSDMTVTAIGLNSLPEEDLHEGSALSNTIQRLASSFAVMLLSVYYDVRWQMIVQSGESAEYAKWMALKEECIALGGLMLLTLPLVLVMNGKKAGVVVGNGKEPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEQ2</accession>
    <name>A0A398CEQ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_25490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00925">
        <property type="protein sequence ID" value="RIE00925"/>
        <property type="gene ID" value="D3H35_25490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="437"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="544" mass="62307" checksum="57B5AFFA956773EF" modified="2018-12-05" version="1">MLKMIIVDDEPLIREGLKSMPWERWGCMVAGEAEDGEDGLALVEETRPHFIITDIRMPGMDGLVFSKTVKERYPEVEILMLTGYQDFEYAKTAMHIGIRDLLLKPTKFDELEKAVRKLIVDIRDREMSRREHDRLRDQMRSALPLLKNKLVHDLLHGYLYAPNVIKDRLASFDIQIGRYAVMSIQIDNRQLFETAYSGEDRMLFEYAVMNIAEETAKSIGLQAVTDYDHDLFSIVLSYGPEYSLADCAKASMKTGIDIQSFIRTYLPFTVSIGISEPWEKIEKINQAYLQSIEALNHNFFLGDDALVRFQDIASEKETAYFFEEEDKQGLINGLRAGDIRKVRETVERMKLRIVQSPGVNIPHLKISLMELAFGSVRAIGQFNPGMLERLMQAAMPLSRLESMATVDRLFDECMRMFEDIAGIVDESRQSRFSSTVAEVMKLIQYDYGEDLSLDMLSEQFKLSTAYLSRLIRKETGNTFMANLTEVRLEQAKRLLESGSKKASEIAGLVGYKDFSYFIQVFKKHTGLTPNEYKDQRTGEGGTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF36</accession>
    <name>A0A398CF36_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Crp/Fnr family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_13505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01806">
        <property type="protein sequence ID" value="RIE01806"/>
        <property type="gene ID" value="D3H35_13505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="14"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="195" mass="23184" checksum="80562755D9F3B9D7" modified="2018-12-05" version="1">MDASLQSYATLLRRFSDIPDSEWQWFAARLHARTLRKYDYFIRSGEQARFIAFCAEGLFRFYYDTENGNELNKSFCGKGDFVASFHSLLLDSPSRLHIQALEDSELWVISYADYIGLYDRHVCWERLGRRMAERLFIKKEQRERELLLCSAEERYRLFVNENPELHERIPLYHIASYLGITPVALSRIRRRINLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF66</accession>
    <name>A0A398CF66_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01220">
        <property type="protein sequence ID" value="RIE01220"/>
        <property type="gene ID" value="D3H35_22760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="898" mass="101838" checksum="055A2F3F3CE958B9" modified="2018-12-05" version="1">MMISKLSVLGEGVAGIMLELSGFRVVETLGSNEEVSLYRVTRIEDGQSFIVKTTSDSYAGSDTTAAFEYEYERLQELNGRGALLPYRLEVSGDRPVLFLRDPGGTTLDQVMRTRRVSFKLQELLETAIAAADCLCQIHHQYVTLHEMTPFYLMVNDNLTEVKVIDVRSSRVEGEQHPVSRSQGRSDSFLPYLSPEQTRRTGMMPDYRTDFYALGAILYEWFAGSVPFLSQNAMNLVYHHLAATPEPVSTRNKSIPRMVSDIVLKCLEKMPEARYASAYGIKSDLEECLVQLRIFGKVQAFSLANHDISERWIVSEGLIGRHAEQQALLQALQRVSEGAHEVIWISGEAGIGKTALVRETLRGAVPAEGFFIAGKFESTSYTRPYEIWAQAIEQMVAHLLMVNPLQAELWKLRILDAAQGCGQLLIDLAPRMSLLIGEQPVVENLPPAEAQTRFYSVMNRFFQLFLGQGQPFVLFMDDLQGADEASIHYLRHLLMDEATKHLLIVGAYREQELLPLHPLNGLMKQLEEQGTPIKQIHLTAYDHAALRMMLGPVMQGAADRIDELISVLLQKTEGNPLILQQFLQDLWSHRLVTFDERSRIWEWDVQRITERNVPDYVAESMADSLKQLSDQAVHVLSAAALLGKQFDLYTLSAITGHTKDQLMEFMQSAVVQRLLQPIHGMRMNYAFQHDRIRQSAYETVSEQERTRLHMEIGLLLAQRMNAGEGISVFEVLSHLNPAAQALVLQGKRRELAEMNLQAGLEAKRSADREASLVYLRLATQLLEEEGWDSCYSLTFQAYQERAEAEFLCANFAGAHDLFHLILEKAATDIAKAQACLMLIRMETNRDRFREVIALCVKALGYLGISYRLNTRSSDLLRQWLRVRWKLRKIAVESFEEYPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFX9</accession>
    <name>A0A398CFX9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01623">
        <property type="protein sequence ID" value="RIE01623"/>
        <property type="gene ID" value="D3H35_25100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017371410" evidence="1">
        <location>
            <begin position="32"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="430" mass="47292" checksum="91DE91D13993EFCD" modified="2018-12-05" version="1">MSANSKWKPFALLVASMMIASLVGCGNNSDATSTPSASSSAPAKEVKLTFWHNYSTASPEEKTLTETLIPKFEADHPGIKVKAVAFPWDELHKKIQIGGNAGELPDVSRLDIIWVPEFQKSDLLVPLDEQFQDFNDVSKQYLTGPLSTAKVGDHYYGLPLNTNTKVLFWNKDLFEKSGLSAAPATTDEFFANLDKLKASNAKGWGFGEPALQGWNMLPWLWSNGADVLSPNFDTAQGYINSSASIDIITKYRDAFKKGLWSGFKQGDIPVTEGHANGTYAMMAEGPWAFAQFQSQFPNFKAMSAQFPAGSTGSVQVLGGEDIGVFKGDHQQEAWEFAKFMTSEEVQVEMGKVGQIPVNLKALDNADIKKIEYFAPFLEQLKTAKARPPIPQWPQIDTILSDTMNAIFLTDRDVKTQLDAAADKIDALLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG78</accession>
    <name>A0A398CG78_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02226">
        <property type="protein sequence ID" value="RIE02226"/>
        <property type="gene ID" value="D3H35_15940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="31"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="117" mass="13472" checksum="690B7258C0D4DE82" modified="2018-12-05" version="1">MDEKVTDEEPRLCGLEGEFAGSSFRLNEQGLSIGRDPLQCSLVFPLNVEEVSRKHCTLWFDESRRVFVLEDHDSSNGTFLQSGERLVPKKAYELQSGERFVLSGSRHWFEVRDARHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGI5</accession>
    <name>A0A398CGI5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_24970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01600">
        <property type="protein sequence ID" value="RIE01600"/>
        <property type="gene ID" value="D3H35_24970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="153"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="5">
        <location>
            <begin position="278"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="583" mass="65574" checksum="3859B1F2EB19AB14" modified="2018-12-05" version="1">MQLKSIQNSIQQVVVAIASALKIEVEVADRQLFRVAGTGAIKSNVWQEMRDEDYVYRRCMDTGEPVIIEAPGHHELCRPCLHFGKCPELGEVCCPIKVEDSTIGVIGLIALQPEQKERLFADLPANLSFLQQMAALIASKMIEHQYYQEQLLIKQKISTLIHYLDHGIVMIDREGRCDFINPAARKLLHLGEEDYPDSDLIAQFPKNLGTKSSGAGESIGQTLFLLTKNGYRQLYVNYHHLDAGKQEWNTVIVLQDPEQIATAASQITEGSALGFEEIIGKNQAIIGLKDLMRKTANSRSPILIHGESGTGKHFFAQSIHYFSERRDKPFITLNCAVLSEDALQRQLFGEPVRGTKHAAHGALERAGGGTLFLDDIAEMPLSAQLTLLRVLEERAIRKEDSAKPIPLELRLIAATDKNLEDLVAQGSFRQDLFYKLNVIPLFVPSLKDRREDILPLARYFLNKHARANSKTFRSMDDGFQKTLVSYHWPGNIRELSNVIEYAVNIESNQELTKASMPAYLRDIDYHSLDLLSDGDLNLRSMEKEAIRRAIIVVKERGESKDKASELLGIGRATLFRKLQEYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGK0</accession>
    <name>A0A398CGK0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_21855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01072">
        <property type="protein sequence ID" value="RIE01072"/>
        <property type="gene ID" value="D3H35_21855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="73"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="295" mass="33164" checksum="ECE2363F940EB8EB" modified="2018-12-05" version="1">MERRGFSWSYFRLQLVFLGPAVLFFSLIVIAPFMLSIYYGLTNWNGVNSEIDWVGLANFKQIVMEDTAFRRAFWFTARYTLVSVVLMNAVGIGLALMLTQKLKTTNLLRTIFFMPNVIGGLFLGFIWHFIFVKGFASAGDALHIGVLQLPWLGTAQTSFWGLVIVSVWQYSGYLMVIYIAALLNVPPEIKEAAKMDGASGPRMLLSIIFPLIMPAFTICFFLAMSWCFKVFDLNLSLTKGGPFRSTESVALNIFNEAFGNNRYGLGTAKALIFFVVVALVSILQVRFTKKREVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGN6</accession>
    <name>A0A398CGN6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L,D-transpeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_14070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01903">
        <property type="protein sequence ID" value="RIE01903"/>
        <property type="gene ID" value="D3H35_14070"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YkuD" evidence="3">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="112" mass="12092" checksum="9266850474F4E6D5" modified="2018-12-05" version="1">MPNYRIIVDLSDFMLYLLDGDTVTRGYPVGIGTIAAATPTGRLHIVNKVPNPGGPFGAFWMGLSKPHYGIHGTNDESSIGKRVSHGCIRMHNKDVVELAGLVPIGTSVTIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH69</accession>
    <name>A0A398CH69_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NHLP leader peptide family natural product</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_13555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01815">
        <property type="protein sequence ID" value="RIE01815"/>
        <property type="gene ID" value="D3H35_13555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036648">
        <property type="entry name" value="CN_Hdrase_a/SCN_Hdrase_g_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022513">
        <property type="entry name" value="TOMM_pelo"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56209">
        <property type="entry name" value="SSF56209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03793">
        <property type="entry name" value="TOMM_pelo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="79" mass="8474" checksum="4636BFA366D12D01" modified="2018-12-05" version="1">MSLESLKVQIIKKAWAEPAFKESLLADPKQAIQAAFGVEIPAAIDLKVVVESSSLYYLTIPPNPEDQGGAGSSTNTVWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHJ9</accession>
    <name>A0A398CHJ9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_16035</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02243">
        <property type="protein sequence ID" value="RIE02243"/>
        <property type="gene ID" value="D3H35_16035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="184"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="244"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE02243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="445" mass="50448" checksum="D8E0CEB3CFB5A773" modified="2018-12-05" version="1">MRSLYMRVFLVTIYTIAVSSFIGFIIANAYYNLELKSYNDYRMFTAADNIRAYIGQYPETMGDFLEQTASLGYQIYVTDARGNDIFYGGEFRKSDLSSAIKESVLSGTEYHGIAKHPNKLFSTSYFDNRLSNTVGVLLEAGAERYALFLRHDTRLQFDELRTFFVLLFAFTVLISIPYFLLSTRYLVQSIVRLTEATKRISQGIFRLKLPTGRKDEIGQLASHFQMMALQLERSDQEKKDFVANVSHEIQSPLASIQGFADSIIRENPDNGQISHYAGIIGQETRRLAALGRQLLLLSTLDNATEAVDKRAFLLQPQLRQTLQLLEWKIAEKEIAVRLSVPARLEILGDKVLLMQVWSNLLSNAVQHIPEGRSIEIRAYREERFCTVAISDTGDGIAADKLPFIFERFYSGDSARQRDKGNTGLGLSIVQRIVRLHGEPSKQKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHK4</accession>
    <name>A0A398CHK4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_28770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00408">
        <property type="protein sequence ID" value="RIE00408"/>
        <property type="gene ID" value="D3H35_28770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="19"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="154"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="368" mass="41995" checksum="6AC5D9F5A89A4C1E" modified="2018-12-05" version="1">MNVSLDYNIEPELPNRKDFRIGCIGSGFIMRDCHLVAYRDAGFNPYAISSRTPANAREVAEQRGISRVYDTWQELVADPQVEILDIAIPPDRQLEIVRAAVTQKHIKGILCQKPLAMNSKEARQIVTLCEEAGVKLAVNSNMRYDQSMRALKTILERGYLGEPVLATIEMRAIPHWQEFLRKYDQLEMLNMGIHHIDIFRYLFGDPERVTALARRDPHTTFPHLDGITQYTFQYANELMATSLDDVWAWPGEGTEKDIYIKWRVEGLDGMAQGTIGWPDYPNRTPSTLAFTTKHAPGEWIRPAWDAVWFPDAFQGTMAQLLRAVETDAEPEIGGRDNLRTMALVDACYRSLREQRTVEFAYELALIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHM7</accession>
    <name>A0A398CHM7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_16285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02283">
        <property type="protein sequence ID" value="RIE02283"/>
        <property type="gene ID" value="D3H35_16285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="299" mass="33023" checksum="154522441B6A93A2" modified="2018-12-05" version="1">MRIEQLQYLLVVAETGSISIAAEKMHVSQPNISHAIVTLEREIGVSLFNRTRAGTFPTEAGKTIIAKAQDILSKLEDLKETAKVHSTLLEDRLSIGAISGVCTSILPRALSNFAAKYPYVEMEVVEEHSGGIEERLLSGKLDLGLMGVTNSGGYSHKHLVAEHFLSCKVMACVGAKSPLADKKSLSFTEILQHPIIGVSEHMSELLNRYGKPRELFHSKGTEAVKCVAAEGMAICFYMDVALKNDPYVTTGQIVPIPIKEDPVVQLYWVHDKKRLTAASEAFVKEVMQQVEYFRRIKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CID0</accession>
    <name>A0A398CID0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02125">
        <property type="protein sequence ID" value="RIE02125"/>
        <property type="gene ID" value="D3H35_15310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="107" mass="12720" checksum="F3437C79950BBA07" modified="2018-12-05" version="1">MSEKLLNEVLGELRAFKSEFREFKSEMLDFKTEMLDFKFEMQDFKLDTEIRLERTESKIDRLERKLDATFEQVVRNTEHDSKWNEIAVSVEEQQTDIKILKKLAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIK6</accession>
    <name>A0A398CIK6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_13485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03126">
        <property type="protein sequence ID" value="RIE03126"/>
        <property type="gene ID" value="D3H35_13485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="180" mass="20009" checksum="CA4529FC0367ACE4" modified="2018-12-05" version="1">MAAIQMHATRLFGENGYNATTVEQIAEAAEVSPSTFFRYFPTKEDVVIKDNYDPLLVAAFEEQPAELSPLQAIRAAMKSAFASFTAEDIATLRERNRLIMTVPELRAASMNNMIQTMHLIAELVAKRTKRRIDDIAVQTFAGAFIGVSISIMFYDAEHPEGDIVQLLDEAWVNLEAGLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIR2</accession>
    <name>A0A398CIR2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF421 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_21955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0702 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01089">
        <property type="protein sequence ID" value="RIE01089"/>
        <property type="gene ID" value="D3H35_21955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.240.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012452">
        <property type="entry name" value="DUF1657"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007353">
        <property type="entry name" value="DUF421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023090">
        <property type="entry name" value="UPF0702_alpha/beta_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07870">
        <property type="entry name" value="DUF1657"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04239">
        <property type="entry name" value="DUF421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="286" mass="31936" checksum="ED7295AFE76417EB" modified="2018-12-05" version="1">MPEWTHIVFRSLGALVVLFIMARILGKKQISQLTFFEYVMGITLGELAGFISTDLEAHYTHGLIAMLVWFTIPFLLELLTLKSIKLRHLLEGKERVVIKEGKVLENNLKKERLTADELLEQLRAKSVFNLADVEFAAMETNGDLSILLKKDKQPLTPSDMNMKKVTEVAPQTVIIDGKIMDEPLATIGLSRGWLRTELEKIGVSVDNVFLGQVDAYQQLYVDLFDDKLQVPAPQGKALLLATLKKSQADLELFAIATRSPAAKAMYETNSAALQQVISDLRPILNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ76</accession>
    <name>A0A398CJ76_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_16785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02370">
        <property type="protein sequence ID" value="RIE02370"/>
        <property type="gene ID" value="D3H35_16785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022324">
        <property type="entry name" value="Bacilysin_exporter_BacE_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01988">
        <property type="entry name" value="EXPORTERBACE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="426" mass="45754" checksum="540E70FCC8C2BBA2" modified="2018-12-05" version="1">MEFSRSLESDSSIETASISSGLDANRPVWKNNPFLFILSGNFISVFGDCFSGVALSLWVLQTTGSAKQMAAVLICHTAISVLFGSVAGTVADRIDRRKLMLAADLFRGSIACTLAFSLFYLDSSFGVMIVLVALSAFSSLFQAPAFHASIGQLVGKERIGQATSAVYLMDNVARISGLALAGVAIASFGGFWAMIFNSATFFMSAVCVVAAGAFPSFSRERREKSTFLKDLVGGFSYIRRDRLTRSIVILNPLLILFVMSSLMLIQVIAVKEWKAGPVAFGLLEMCIPLGYMIGAGLIMAFGSKLGHRGWWIFSGLLTLGPVFYLISIVPYAHTALPFILLCGMLFAFCTMMIQIILRSEVQTDMQGRIYGTLGAITGVAPSLGLVASSALADHVGAKFMLGAQGVTLFLIALVAVTFLKTIRTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJE3</accession>
    <name>A0A398CJE3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Histidinol-phosphatase</fullName>
            <shortName evidence="7">HolPase</shortName>
            <ecNumber evidence="4 7">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_19460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="4 7"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02813">
        <property type="protein sequence ID" value="RIE02813"/>
        <property type="gene ID" value="D3H35_19460"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="PTHR21039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="8">
        <location>
            <begin position="4"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="270" mass="31241" checksum="1DDB324704BE1643" modified="2018-12-05" version="1">MKFDLHTHHDRCGHASGSIEDYIKAAIDAGMTILGISDHSPYFAREEDHAQPYIAMAKSEFPRYVDEVLRLKERYKDKIEILLGVESDFFPEHIDKYRAEYEKYPFDYIIGSVHQTRGVSIFNRNRWKGLNARQQTDEKMHYYELIRQSVHTGLFQVLGHIDAMKGYYPAFQDIAGAEAEIDAALQAVAEHDIAIEINTSGKTKDVGGWYPSDAMLERALHFGVDVTFGSDAHIPDRVGDEWELVRRRLKEIGFKRWVFYRRKAKVIVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJV4</accession>
    <name>A0A398CJV4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_17095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02422">
        <property type="protein sequence ID" value="RIE02422"/>
        <property type="gene ID" value="D3H35_17095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="132"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="374" mass="41835" checksum="B5F6D9267CD6EC21" modified="2018-12-05" version="1">MKTTKYGIVGTGYFGAGLGRLLHAQEGAKVVAVYDPANAEPVAKELNCDVEKSVESLCQRADIDAVIVASPNGYHKHPVLCAAENGKHVFCEKPIALSYEDCNEMITRTKEKGLIFMAGHVMNFMDGVRTAKRLINEGRIGDLLFCHAERNGWEEPQSEVSWKKLRHISGGHLYHHIHELDFIQFLMGPAERVSMIGGNVAHQGERYGDEDDMLFISLEFPNKRFATLQYGSAFRWSDHNVKIQGTKGAILIDMQDVKVVLKTPEGEERFLLHESKEVDEDRTRIYKGLEMDGAIMYGKPSAKPPLWLQGIMKKEMVYFHGIMQGAEAEEEFKPLLDGTAARAAIATADALTRSLQEDRKVSINEITEKEAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJW1</accession>
    <name>A0A398CJW1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02635">
        <property type="protein sequence ID" value="RIE02635"/>
        <property type="gene ID" value="D3H35_18310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="165"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="400" mass="44384" checksum="2EC303455928ABB7" modified="2018-12-05" version="1">MTIKEKGLEGWLAFVGKTVAEGQLLQATFSQPRRKDGDIAAKLTVRPIAMKNGTFYQFESLQGNKAYHDNVPAEQAEAQLIETMAAYKQALFKTPEADVQVLANKKGELTLLRGAATSKIKAASSAAQSHNRSKAYVIPEGEPVPFLVRLGVMTEDGRVVKAKYDKFRQINRFLEMVSDVLPDLPRGKELTVVDFGCGKSYLTFALYHLLAVRERLPVRIIGLDLKKDVIETCSKLAVDLGWDKLAFFVGDISDYRGEASVDMVVTLHACDTATDAALLQAISWDASVILSVPCCQHELFKQIKQPALSPLLKHGILKERFAALVTDAVRANLLEQAGYRTQIMEFIDLEHTPKNLLIRAVRGSGDRSEETAAEYAVFRDLLSISPFMEKRLAEIRPKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJX1</accession>
    <name>A0A398CJX1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YycI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01479">
        <property type="protein sequence ID" value="RIE01479"/>
        <property type="gene ID" value="D3H35_24300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018604">
        <property type="entry name" value="YycI-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09648">
        <property type="entry name" value="YycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YycI" evidence="1">
        <location>
            <begin position="45"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="255" mass="28902" checksum="88DA6F865FE0D9A5" modified="2018-12-05" version="1">MDWGRAKNVLILAFLMLNVLLGYQLWSEWRDQGSSSVDWTSLPPDTQQIMQEKNIRVEGKIPTETPEMRILTFTLKKQPSKSDKAAEKTAIEPQPESRIVFYRKELESALGGTIPDLKHYEYDQGWGNREGVFVLNRMVDGYPMFDIRLELYNSDQRIMAYRQDTIQTLSSEGSKDQQVLPAAQAVARLIDYNLQAGSVIKDIRLGYHGQLFDTISAPSWRVLLESGEVYYVHAISGDVSTDKGTTLTSANSNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK22</accession>
    <name>A0A398CK22_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_20940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03053">
        <property type="protein sequence ID" value="RIE03053"/>
        <property type="gene ID" value="D3H35_20940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="2">
        <location>
            <begin position="173"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="195"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="371" mass="41506" checksum="314F1B4F2AA2BAEB" modified="2018-12-05" version="1">MVLKQELTPEHLLRIIFDYTAKIASETKLNSVLVLMANMGREMILSDRCTVWLIDAVREELYTTVAHGVDEIRIPFGSGFVGTAIETGESIIVEDAYNDPRFNPDNDLKTGYVTKSIISIPFRNNEGNIIGAYQAVNKMTESAVFTTRDLDMLSLAASYAGKSLESVLLHQEIVDTQREIISTMGEIGEIRNKETGNHVKRVADYSYVLALGLGLSEYEAELLRTASPMHDIGKVAIPDAVLLKPGKLTDEEYDIIKSHTKIGHQLLKGSRRELLRTASIVAEQHHEKWNGTGYPNGLKGEDIHIYGRITAVADVFDALSAERVYKAAWPIEKIEALFLEERGRHFDPAVVDVFFETLPKLLAIREQFSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK98</accession>
    <name>A0A398CK98_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YheC/YheD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02775">
        <property type="protein sequence ID" value="RIE02775"/>
        <property type="gene ID" value="D3H35_19245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026838">
        <property type="entry name" value="YheC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38437">
        <property type="entry name" value="PTHR38437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14398">
        <property type="entry name" value="ATPgrasp_YheCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="223" mass="24764" checksum="F2FFA7BAF52139B3" modified="2018-12-05" version="1">MNGSLGRQLASKWIKTNALLANPYVARHIPPSRLFNRENLRRMVAIHGMVVLKPVRGAGGHGLMKVTAGGGRYSLKHKSQTRSFGSLSGLIRAVDATRRGRPYLIQKGIHLATVSGRPIDYRVKYVKAGGTWAYRSMVGRIARRGLFVTNLCRGGTMVTAAQGIRRSLSQRAVGRKKQEMRNLTKISTSLLESRFPGIGQLGFDYGIDRRGHVWMLEVNTRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKG6</accession>
    <name>A0A398CKG6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_19455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03203">
        <property type="protein sequence ID" value="RIE03203"/>
        <property type="gene ID" value="D3H35_19455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="313" mass="35396" checksum="B6F11CF7726142C9" modified="2018-12-05" version="1">MAQRNEPYDYHHLEHAKHQTKSRRTLWITLLLTLFFTVVEIVGGIMSNSLALLSDSAHMVSDVIALGLSMTAIYLSERPSDAKYTFGYLRFEIIASFLNGLALCVIAVGIFIEGARRFIHPEELEFGLMLTIASIGFVVNLVLTIILSRSHHEEENLNIQSALWHFIGDLLSSVGVILSAILIYFTGWLSFDPLISVVIGCIIFIGGARILRESTAILMEKVPDKFDLEEIRSALRKLEGVEDVHEMHLWAISTNHYSLTAHMFVRSDIQPFCIILAVNDMLEKRYGITHSTIQMEHADIHPHGEYGKLFQHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKM1</accession>
    <name>A0A398CKM1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ald_Xan_dh_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03263">
        <property type="protein sequence ID" value="RIE03263"/>
        <property type="gene ID" value="D3H35_11185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="24"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="167" mass="18192" checksum="5E830292D6B5994B" modified="2018-12-05" version="1">MGLVTKEKSGSRWRIRPDGPAKVTGSLVYLTDMRHPDELIGAVLRSEHPHALIRSISTEKAVALPGVHAVLTWRDVPGLNGFGIAKPDQPVFCEDKVRYVGDAVAAVAADSREIAAEALALIEVDYELLPVVDEALPFRFGNVPATTPHPSRVLLRHLAKPAPLRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL63</accession>
    <name>A0A398CL63_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_28535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00371">
        <property type="protein sequence ID" value="RIE00371"/>
        <property type="gene ID" value="D3H35_28535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002808">
        <property type="entry name" value="AdoCbi_amidolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01955">
        <property type="entry name" value="CbiZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="240" mass="25719" checksum="A67D0C918FC1EF89" modified="2018-12-05" version="1">MTQPFRQAVSRYRSPLLPELLVQYEADRILIHSNAVHDVLSNAPCNGGWARANRFVNWKVPLSYDCTDPESMMLTELEKWGYDRAATVGLQTAAHLTHASFAEEAGDEFKLLACATAGTGNAARAGLARETFSAYEPGTVNIIVLIDGKMTPSAMVNAVISATEAKSAAFADLQIKDCRHDRIATGTSTDAALIAASQSSAYGPVHRYAGAATTIGNAIGRLVYDTVHEAVRTQGEARFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL91</accession>
    <name>A0A398CL91_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DedA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03185">
        <property type="protein sequence ID" value="RIE03185"/>
        <property type="gene ID" value="D3H35_18345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="202" mass="22851" checksum="80637D9DA732C925" modified="2018-12-05" version="1">MDTIHEWLSQLLQWVESLGYWGIIIGLAIEVIPSEVVLGYGGYLVSQGDITFLGAVICGVIGAILQQWLLYAIGRYGGRPFVERFGKYLHIKAKHIDIAERWFDKYGTIIVFTGRFVPVMRQVVSIPAGMAKMKLSTFTILTVLASIPWSILFVWLGWSLGDQWEQIDEKAAPYVQPIILCAIVILIVFFVVQYLRKRGKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLE5</accession>
    <name>A0A398CLE5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CMP deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_05950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04166">
        <property type="protein sequence ID" value="RIE04166"/>
        <property type="gene ID" value="D3H35_05950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016473">
        <property type="entry name" value="dCMP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="PTHR11086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006019">
        <property type="entry name" value="dCMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="180" mass="19857" checksum="8AF32766D9474E72" modified="2018-12-05" version="1">MTASVRKDWDTYFMDIAFMVSTRSRCPRRHVGAVLVQGKKLLGTAYNGAPMGVPDCSEAGCMIVEELERVPQGAGAGAGAGDEAGPVKKQRCIRTIHAEQNLLLFTDRNDREGSTVYVTDQPCWTCSNMLANSGVAEIVYIRMYPKDHEKVATLMRQRGIVFRRIEGYVPPPDTEVQDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLE7</accession>
    <name>A0A398CLE7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_28540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00461">
        <property type="protein sequence ID" value="RIE00461"/>
        <property type="gene ID" value="D3H35_28540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="231" mass="26080" checksum="A1DA80F6F4EBD282" modified="2018-12-05" version="1">MQTRKGSEIVFEQIKRQIETEQFAPGAKLPTVVELAESFEVGRSTVREALSALKAMGWITIRHGGGSFVSAQLPTGEEGAGLAFNTELLQEVLEVRKFIEVGCATLAAKRRTEQNLAELRATLEEMAASLDREEESDRADIRFHLLIAEASHNSLFGSMMESMTERMRESMKESRRLWFFAERASTEQLLQEHKDIYAAIEAGDEQLAADRMMHHLQKVENVIGRLRQPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLL1</accession>
    <name>A0A398CLL1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDP-4-amino-4, 6-dideoxy-N-acetyl-beta-L-altrosamine transaminase</fullName>
            <ecNumber evidence="4">2.6.1.92</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pseC</name>
        <name evidence="4" type="ORF">D3H35_15045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.92" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03140">
        <property type="protein sequence ID" value="RIE03140"/>
        <property type="gene ID" value="D3H35_15045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020026">
        <property type="entry name" value="PseC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03588">
        <property type="entry name" value="PseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="401" mass="43941" checksum="681443AFF50252E8" modified="2018-12-05" version="1">MDQQVGFDSFALGGSEMREKMLPYGCQQIDDDDVAAVVDILRSAWLTQGPAIERFERDIADYSGAKHAVAFANGTAALHGACYAAGIGQGDEVITSPLTFVASSNCVLYCGGKPVFADIRPDTYNLDPQAVLEQITDKTKAIIPVDFSGQPAEMDAFSAIARDHGLVVIEDAAHSLGAEYGGRRTGSLADMTMFSFHPVKHITTGEGGIIVTDSAEYADRLRAFRSHGITRDPGQLLRNDGPWYYEMQSLGYNYRITDLQAALGSSQLKKLDTFVARRREIAAAYTGALAGVPGLQVPYQHPDTNSSWHLYVLRWKKDILPGGRDRAFDILRSLNIGVHVHYIPVYQQPYYQSIGYETTVCSHAEAYYSEALSLPIFPGMTDRDVQDVIDAVLETVNLLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLM7</accession>
    <name>A0A398CLM7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Allophanate hydrolase</fullName>
            <ecNumber evidence="2">3.5.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.54" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03553">
        <property type="protein sequence ID" value="RIE03553"/>
        <property type="gene ID" value="D3H35_10970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004039">
        <property type="term" value="F:allophanate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="460" mass="49167" checksum="5493339F806EACC4" modified="2018-12-05" version="1">MKKTAVLPNTLTIEGLRELYRNGGTTPTEVVVEIIRRSQEDEEMNIWITPPELSRIEPYLRKLGEVDPGDAPLWGIPFAIKDNIDWTAAPTTAACPAFAYAPSEDAAVVERLIAAGAIPLGKTNLDQFATGLVGSRSPYGETHNSLRPELISGGSSGGSAVAVARGQAAFSLGTDTAGSGRVPAHLNRLVGYKPSMGAWPVKGVVPACESLDCVTVFAWNLEDATAVDRVVRGPHDEDPWSRELPLPVPSALPSRICVPAPGTVEFYGPFAADYEQAWEAALLKLKGLGITVEETDISLYGEAAAVLYEGPWVAERWAGLAEFVESGAGDVFPVTERILRSGADSRHTAAALFKAMHKLQAFKLEARKRLKDAVLVLPTAGGTWTREQVRQDPVATNRDMGKYTNHCNLLDMCAVAVPSGDAADDLPFGITFFAMAEREDLIRGAAGAFADSLLTGGARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLS1</accession>
    <name>A0A398CLS1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04296">
        <property type="protein sequence ID" value="RIE04296"/>
        <property type="gene ID" value="D3H35_06700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="4"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="322" mass="36267" checksum="321238562DE29ABE" modified="2018-12-05" version="1">MKILVTGGAGFIGSHLVDSMLADGHRVIVVDNFDPFYDRSIKERNIKQHLEFANYDLVEADIRNRETMFEIFNKYKPEVVVHLAAKAGVRPSLEDPLSYVEVNINGTVHLLDASVQYGVKKFIFASSSSVYGLNEKVPFSEEDPILRQASPYGATKASCEALCRSYSNCYGLPIAALRFFTVFGPRQRPDLAIHKFAKKILNKEVIQLFGDGTTSRDYTYVDDIVQGIKSTINYCTTGFEVFNLGNDRPTQLIELVNCLENVLEKKADIQWLPEQIGDVPRTWANISKSKELLNYQPQVDMLTGLELFASWLNPDLALLKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLS3</accession>
    <name>A0A398CLS3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_18930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03192">
        <property type="protein sequence ID" value="RIE03192"/>
        <property type="gene ID" value="D3H35_18930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="64"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="270" mass="30296" checksum="899D523E584BD502" modified="2018-12-05" version="1">MAGSIVIHLLLFIIAVVTIYPALWVVLASFRPGTALYSEHLIPERLTLGHYRELFEMFPFAQWYVNTLKIAVVSMVCSTFFVLLTGYAFSRFRFYGRKGLMTGLFVLGMFPSFMSMVAVYILLLNMNLLNTHSALIFVYSAGAAMGYLLVKGYFDTIPRSLEEAARIDGANHWIVFFKIFVPLSRPLIVYLSVTSFAGAFNDFIFAQMVLRTKENQTLAVGLYNMVSSQFSTQFTIFAAGCVLVALPITLVFMFFQRFLVEGLTAGAEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLS8</accession>
    <name>A0A398CLS8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01818">
        <property type="protein sequence ID" value="RIE01818"/>
        <property type="gene ID" value="D3H35_13570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="44"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="258" mass="29500" checksum="C63DFE3084FFD241" modified="2018-12-05" version="1">MSVSFSYYGELCTEVYDLTKEVGQSFDGDLEYYRSRLEGCKGRILEAMVGSGRVIVPLLQAGFDMDGVDYSPEMLASCRQRCEERGLKVNLYESHLQDLILPQQYEAIIIPGGSFLLIERREDSLHALRRLYEHLQPGGRLILDLFLPDNRFEIGPLGGTSTFHLPDGDIITMESKLVEADLFNQYKITYLKYEKWRKGALVQTELQRFALRWYGVEEFKLVLESIGFSDVTISADFVHGKPPADGNQKFVYEAIKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLT4</accession>
    <name>A0A398CLT4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Alkanesulfonate monooxygenase</fullName>
            <ecNumber evidence="2 6">1.14.14.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">FMNH2-dependent aliphatic sulfonate monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ssuD</name>
        <name evidence="8" type="ORF">D3H35_26845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the desulfonation of aliphatic sulfonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an alkanesulfonate + FMNH2 + O2 = an aldehyde + FMN + 2 H(+) + H2O + sulfite</text>
            <dbReference type="Rhea" id="RHEA:23064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:134249"/>
            <dbReference type="EC" id="1.14.14.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SsuD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.5" evidence="2 6"/>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00807">
        <property type="protein sequence ID" value="RIE00807"/>
        <property type="gene ID" value="D3H35_26845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008726">
        <property type="term" value="F:alkanesulfonate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01229">
        <property type="entry name" value="Alkanesulf_monooxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019911">
        <property type="entry name" value="Alkanesulphonate_mOase_FMN-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03565">
        <property type="entry name" value="alk_sulf_monoox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0288">FMN</keyword>
    <keyword evidence="5 6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="396" mass="43140" checksum="8C5C6F1B7975EDA5" modified="2018-12-05" version="1">MELFWFIPTHGDGRYLGTSEGGRAVDYGYMRQIAQAADQLGYTGVLVPTGKACEDAWVAASALIPVTRSLKFLVAVRPGLMSPTLAARMAATFDRLSEGRLLVNVVTGGDPVELAGDGMFIGHDERYDQTDEFLSIWRAVLSGERVDFEGNYLKTEGAELLFPSLQRPHPPLYFGGSSAAAHEIAANHVDVYLTWGEPPGQVARKIEEVRARAAERGRTVRFGIRLHVIVRETEQEAWEAAERLISHVDDETIAAAQSIFSRYDSEGQRRMAELHGGDRSALVISPNLWAGIGLVRGGAGTALVGDADSVAERIKEYAALGVESFILSGYPHLEEAYRAAELLFPRLPFVRNRLAGAPAQDNRQVGELVAYNLRPAAGADRQAEGQQHVAVQKNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLY0</accession>
    <name>A0A398CLY0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00651">
        <property type="protein sequence ID" value="RIE00651"/>
        <property type="gene ID" value="D3H35_27180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="108" mass="13073" checksum="EE0EDACC735AC34F" modified="2018-12-05" version="1">MGNIQISDDFFAKKLEEAKVHFERALDCKHTEFDDLYPYMIEHPQFFWYKRYVAWSELLTTVKLSEELGIDWTSSFTERQAEYVRKRVMSSTVLDFWYETNDTREHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM58</accession>
    <name>A0A398CM58_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF4080 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_10415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03733">
        <property type="protein sequence ID" value="RIE03733"/>
        <property type="gene ID" value="D3H35_10415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025288">
        <property type="entry name" value="DUF4080"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13311">
        <property type="entry name" value="DUF4080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="4">
        <location>
            <begin position="173"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="591" mass="68560" checksum="F10488D20471F1E6" modified="2018-12-05" version="1">MNVVLATLNAKYIHTSLAIHYLKAFCKDEFPIELAEFTIKDPAMNIVSDLYSRKPDVIGFSCYIWNIEETITVIDMLRKVLPDVKIVLGGPEVSYDTDHWMDRLKDVDFIIMGEGEETFRDLLRQIASGDNKYHFVFGLAYRKNGQAVINPGRPKLDLNDIPSPYRFAEDIPSLPNRVVYFETSRGCPFSCQFCLSSIEVGVRYFDIEWVKAELTYLIDNGAKLIKFVDRTFNIKREYAMEVFQFLIDNHRGCVFQFEITADIMRPEVLDFLSEHAPPGVFRFEIGVQSTNDPTNLAVQRRQNFAKLSRTVNKVKSSLKIDQHLDLIAGLPHEDYDTFRRTFNEVFALRPEELQLGFLKMLRGTGLRRDADKYGYIYMDRAPYEMLGNDLMPFSDIVRIKRLEDVLEKYWNSHRMDRTMEYLIGSAYPSPFDFFQKFGDYWESKGWSRIGHQLEDLFTRLWSFLQEDAAEGLDMDVAFGLLKIDYYLQHKYKPRKTWWEDRLDKKEWTTGLKWAAERLGMDERELNKKAVLDRLPFDYGAFLADGRPDRTGGGSALLVLYSGEDAPPQLTAMPIPDSWVTEPDASSPSKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM86</accession>
    <name>A0A398CM86_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_11885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03372">
        <property type="protein sequence ID" value="RIE03372"/>
        <property type="gene ID" value="D3H35_11885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="151" mass="18023" checksum="F88C5FFE53D27478" modified="2018-12-05" version="1">MPKSIELSDEQYRTLIELVYLGSWIANATKLSEEEMNQDYIKLEQLLYKQSKMFKSEDIIALDKRTNSYYTTSFFEDGMMPVVEQYDDDSFWEELSSRLAKRDLLKETGPVHKWSEKQLSRKYELEEYYEQEFTENGLRNLVLKKERGAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMN3</accession>
    <name>A0A398CMN3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_14890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02048">
        <property type="protein sequence ID" value="RIE02048"/>
        <property type="gene ID" value="D3H35_14890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="209" mass="22288" checksum="0AC042667EDBF860" modified="2018-12-05" version="1">MNGGSGCAACGYIGDWQRYIAGEGETSEREAAEERLEQCEGCMDAYISAVEWLETAEAESSRPYGLLDQAWVDRTMAAVRHAGAGAGDDTVAAIVLETTAVGHAPSDATQPTLTAERRAAARGGSSFREPWRRRAAIHYAVAVGLTLVLLLTGGFHQLTGGLSKPVAEQGVLRPEQNQGGKQSPGGEPEASWSDRMVDRTVAWLDKLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN53</accession>
    <name>A0A398CN53_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_28370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00344">
        <property type="protein sequence ID" value="RIE00344"/>
        <property type="gene ID" value="D3H35_28370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005085">
        <property type="entry name" value="CBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM_fam20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03423">
        <property type="entry name" value="CBM_25"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01066">
        <property type="entry name" value="CBM_25"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017226601" evidence="4">
        <location>
            <begin position="37"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="563"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="656"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="842"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="6">
        <location>
            <begin position="1019"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1097"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1125" mass="120379" checksum="27B2DC940753183A" modified="2018-12-05" version="1">MVIRTVRKSFSPLLVLALFLSVFINVLLVPPKPVHAASIGTVDENDTIYQIMVDRFNDGDSSNNATGTAIRYAENSEEDFRYMKGGDWQGVIDKLGYIKNMGYTAIWISPVAEPQMTNRDNNGSGKNTAYHGYNVKDPNKANPYFGTKEKLKELVDSAHALGIKVVIDVVPNHIGDYMLGTQAFYDIPSLQPAAPFNNPAWYHHNGDINWSLADGNYDPSIQAYLENHDLGGLDDIDFDVPAAKQAIFDSIKGWFDYTGADGARVDAAKLMWPTDIGALQNYLGVNTFGENFDGNAEFVSRWVGTNKEWGMLDFPLFFQVLNSFAYGQSFDANVKNAFAQDFRYNGNENHMVTFIDNHDRNRFLTEAGGSVEKLQNALAFIFTVRGVPVVFQGTEQNKGNGNGQIITGGISDTWNRWSMVKRDTNGSVIQNYFDENTNTYQFVAKLNQIRKTYEALRKGKQREMWSAQNLYAFSRRVESGTNVGQEVISVFSNASSGTQTVTIPLRAESTLTVGTVLVNQLNTSDSVTVQSGGATGKQITVSVGSNSGKIYAKQLTDTIAPTVPTNVTATAVSSTSIQVGWTASTDNNAVTGYEVYRNGTLVGTPAGTSFTDTGLTAQTTYSYTVKAYDAASNKSALSSPPATATTLQVDTQPPSVPQGVTATAVSSSAINVAWTASTDNISVTGYEVFRNGTLIGQTASLTYADTGLAASTAYSYTVKAFDAAGNRSDLSAPPAVATTSAGNNVTIYYKQGFTTPYIHYRPAGGTWTTTPGVPIPAAEVTGYNKITINIGTATQLEACFNNGSGTWDSNNQQNYLFGVGTWTYTPTGNIVSGGPDSQAPTVPLNVGAIELSATSISVTWNASTDNVAVTGYEIYRNGTLVGTSTSTSYTDTGLAASTLYSYTVKAYDAVGNKSALSSPPATATTAAGNTTTIYYKNTNFTNSYIHYKIDGSSTWTTVPGTQLQASNFPGYNAITINLGSASGLTAAFNNGSGSWDNNGGNNYTFASGTWSLVNGNKTQGQPQADSVTFRVTVPSSTPANGPVYISGSFNSWNAADPAFQLTKGSDGVYSITLSLSGTAIQYKFTRGSWATVEANSNGSDISNRSLTPSGGAQTVNATVQRWKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN80</accession>
    <name>A0A398CN80_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ChbG/HpnK family deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_23645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01367">
        <property type="protein sequence ID" value="RIE01367"/>
        <property type="gene ID" value="D3H35_23645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006879">
        <property type="entry name" value="YdjC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31609">
        <property type="entry name" value="PTHR31609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04794">
        <property type="entry name" value="YdjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="272"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="330" mass="36935" checksum="00AED02DE12367C6" modified="2018-12-05" version="1">MTKFLIVNADDFGLSPGVNRGIAEAFAAGGITSASMMVNMPGFQDAVRLARLNPFLGVGLHFNLTYGKPLSEPRLVPSLVNSSGAYLGIRSAAAWTDKDIATELAAQWNRFVSTGLRPTHLDSHHLLHQNIPSVFNVMASWAEREGIPMRRSQTPIEPNGQQAWTTDYIWLDTYHEEDGLLRLLRCLHNLPDGTTEIMCHPGYADDILRELSEWANVREAEQAVFCHPSVGLTIQALGICPIHYGMLIKKRCEMERIPIPSLAAAPTDLIPAIEPAPEPQPLREKQQRLIHSGKNRKKKRSPAKRRRAGRASPARGRRRQRSRKRRKRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN84</accession>
    <name>A0A398CN84_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03762">
        <property type="protein sequence ID" value="RIE03762"/>
        <property type="gene ID" value="D3H35_09405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="133" mass="14669" checksum="8241A85592F6AC81" modified="2018-12-05" version="1">MEKHVRQVVAELLDAGYEPDSQLAFYFEPDAAHTEADWEERAHLPLLHLFGKPSKLAGVSLKELGTSFFERSKLRLLPTAEYENGWRITPLNGSFKSADPDAASVDHSGGIVPKEGAPPWLNTSSKENGRKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN87</accession>
    <name>A0A398CN87_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4183 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01377">
        <property type="protein sequence ID" value="RIE01377"/>
        <property type="gene ID" value="D3H35_23700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025237">
        <property type="entry name" value="DUF4183"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13799">
        <property type="entry name" value="DUF4183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4183" evidence="1">
        <location>
            <begin position="61"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="140" mass="15223" checksum="F927E615D65C6F93" modified="2018-12-05" version="1">MSGSAKDDRDIRIEILIKPHIEIGTVIIMPCPDPVPTPPPCRVIPTVRRYFHIAVRPIHLAAPAIIPASRFADDAGNPADKLPNYGEYGYCNCFINGVMQEGDLYHTHSLGLVIAATGQTIPAGTPIILEFVKLDVEHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNH5</accession>
    <name>A0A398CNH5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-hydroxamate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_22215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01131">
        <property type="protein sequence ID" value="RIE01131"/>
        <property type="gene ID" value="D3H35_22215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="88"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="347" mass="38071" checksum="29082B840CDDF478" modified="2018-12-05" version="1">MIIIINIIQEGIMRLTQKNIALVAFILLFSIVLAACGNDKNDAGASKTAPASPAAAQQAQETSSAPAEQPATRKVTHALGETEIPTEPKRIVADQYIGHLLALGIKPVGARGDLMKSPFIQDQFEGVADTGSPMNLEKVLELKPDLIIVQSEDNYEQLSKIAPTIVYEYGKINTLEQLKLFGDILGKQKEADEWIAAFDAKAKSYREKLAGAVGPDETVSVIELWAEGPFVFGNNWGRGGYSLYNALQLKPPAIVAKEIIDKEQFRALSMEVLPDYVGDFVFLTVYAENGGDKKAQEIKDSAIWKSLKAVKNNRVIELRIEDMAPGDPISLDKQMDIQFEKLLALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNJ6</accession>
    <name>A0A398CNJ6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01151">
        <property type="protein sequence ID" value="RIE01151"/>
        <property type="gene ID" value="D3H35_22350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="178" mass="17630" checksum="88C5C40797C284EB" modified="2018-12-05" version="1">MSTISFVAGEVASGFTLGDGDGKGVGFLLGVGSLLGDGSLLGVGFLLGAGSLLGAGFLLGAGSALGFPDGLGLASRLGLASGLELADSPGLASALGLGSSEALGLASGLEEASLVAVDGLPLLFALFLPEHALSKPPIKTAAIMTDINRIFMVYILLVVIGVCLTRVLRRALVRQCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNL0</accession>
    <name>A0A398CNL0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03830">
        <property type="protein sequence ID" value="RIE03830"/>
        <property type="gene ID" value="D3H35_09765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="265" mass="30218" checksum="22DF4FD8ABD8F3D0" modified="2018-12-05" version="1">MIEKWRHIGEEIIRFRLADEEAARVTRAVLGEMFSYRSSEAIADMTVTIRSGYGSRYADHTSVAIGRDDNGLFFDRQDFQLRISADDLQAEIRFHDYYGLRTALLSWYSSIINRADWGIVVRSSCVVNEGQACLFIGASDARESTIASLSRPRVLLSDETSLIRIFSEGSVRVYDSPFRNVCKEPANVGFAPLQRIYLLRESPIVRTTPLPKDEAMLMLLNEVVHENRDAGESAKLVRMCKRLVERVPVYEMELEKNKRVWGAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP81</accession>
    <name>A0A398CP81_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03119">
        <property type="protein sequence ID" value="RIE03119"/>
        <property type="gene ID" value="D3H35_13090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036073">
        <property type="entry name" value="Desulfoferrodoxin_Fe-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49367">
        <property type="entry name" value="SSF49367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="210" mass="23883" checksum="C5E698B10533C6FF" modified="2018-12-05" version="1">MNSVKVGGLIQSLRKEKNMTQNDLALLMNISDKTISKWERGLGCPDISLLNELSTILGVNIEKILSGELQSNDRDSGSMKRVKFYSCKSCGNVMTSTGAINISCCGRILETLQIKKDSGDHDIAVHETEDDYFVTLEHEMSREHYISFAAYVSYDRFMLIKMYPEQNAELRFPKMYGGSLYVNCTQHGLFKHEKIEQRRIVKSEKSIADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP95</accession>
    <name>A0A398CP95_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_07405</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04403">
        <property type="protein sequence ID" value="RIE04403"/>
        <property type="gene ID" value="D3H35_07405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="324"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="427" mass="45353" checksum="28DA4A90EDBA75A4" modified="2018-12-05" version="1">MTDASVHVEAGAAARMTEQEPLGKKIPLFRNKTFISVFAGNTLSTMGEGFNTIAIGYWVLSTTGSAKAMTAVMLPQMILGLLLGTIAGTLADRKNRRTIMLSMDLIRAVLMIGVAAVVSGSSGWGIWALVPLLTLINAASQFHSPAFQSSLIYIVGQEQVGRATGLMQVTDTLARLGGLALGGWTVAAFGGPAAVTVVGAMFALSALCVMIAGPFPIPAAKSDNRKSFWTDLRLGLAFIRKHPFARSVSLLLPSVMIFFTASMMLFQVMAVTVWHATPKEFGLMEAAIPIGYAGGSGLMLLLNRRMTRRGWWIGVSVLLAGPNLIVMSAMPDVFSALPFVFLIGFILSVGTVLVMIALRTETAAEFQGRVFGAIGSLTNLSTPVGLVMSGILSDRFGADRMLFLNGLGLTAIGLCCIALLKPLRQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPE3</accession>
    <name>A0A398CPE3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_26830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00804">
        <property type="protein sequence ID" value="RIE00804"/>
        <property type="gene ID" value="D3H35_26830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="17"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="332"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="366"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE00804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="577" mass="63732" checksum="FE133B584CE382F0" modified="2018-12-05" version="1">MFRLFRYLKPYRLQVTAVLVLVLLQSLAELYLPTLMADIVNDGIIKKDIPYIWKIGGFMLLVTVVGTFVAVMASYLSAKLASVFGKIVRSRVFSHVEKFSLQEFDKIGTASLITRTTNDITQVQQVLMMMMRLMVMAPMMCIGGIIMAVSKDATLSLVLVAVIPILALTIFLIASRGIPYFKVMQKKLDKLNLVLREALTGIRVIRSFNRIDDEKRRFDEANRDLTETAVKVNRIMAYMMPMMMLIMNFSSLSIIWFGGLRISTGSMEVGDLMAFLQYAMQIMFSLMMVSMMFVMVPRAAASAVRINEVLDTVPVIHDAPNPSRKMGERGLVEFEDVTFSYPGAEKPAVSGITFAAKPGEITAIIGGTGAGKSTLLHLIPRFYDIQGGRIRVGGTDVKELPQQQLRSSIGLVPQKAVLFTGSIADNIRYGKEEASDDEVNRAAEIAQATEFISGMQDGLNSVIAQGGTNVSGGQKQRLSIARALVRQPDIYLFDDSFSALDFKTDAKLRAALKKETAVSGSTVLIVAQRVSTVMDADRIIVLEEGRIAGIGKHRELLEQCAVYREIVESQLSEEEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPQ1</accession>
    <name>A0A398CPQ1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9 10">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 14" type="primary">dnaA</name>
        <name evidence="14" type="ORF">D3H35_23995</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the DnaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01431">
        <property type="protein sequence ID" value="RIE01431"/>
        <property type="gene ID" value="D3H35_23995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024633">
        <property type="entry name" value="DnaA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11638">
        <property type="entry name" value="DnaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="12">
        <location>
            <begin position="143"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="13">
        <location>
            <begin position="355"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="151"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE01431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="449" mass="51155" checksum="8282716DC2212332" modified="2018-12-05" version="1">MDSRHNEIWQQVLSVIQTKLSKPSFDTWFKSTKASFLSDDVVVVTAPTTFAAEWLETRYTKLVESTLSEYIGRHVEAKFAIEEARGAEPPAPPQQVQVRQPVTDDTIIHMLNPKYTFDTFVIGAGNRFAHAASLAVAEAPAKAYNPFFLYGGVGLGKTHLMHAIGHYILEHNPHMKVVYLSSEKFTNEFINAIRDNRGESFRNKYRNIDVLLIDDIQFLAGKEGTQEEFFHTFNALHEESKQIVISSDRPPKEIPTLEERLRSRFEWGLITDVQPPDLETRIAILRKKAKAENLDIPNEAMMYIANMIDSNIRELEGALIRIVAYSSLTNQDISSHLAAEALKDILPTGRNRLITIQDIQQRVGEFYGLKLEDFKARKRTKAVAFPRQIAMYLSRELTDYSLPKIGDNFGGRDHTTVIHAHEKISQQIKVDQDLYKIINSLTEKIKNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPX9</accession>
    <name>A0A398CPX9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2953 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_03665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04603">
        <property type="protein sequence ID" value="RIE04603"/>
        <property type="gene ID" value="D3H35_03665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021338">
        <property type="entry name" value="DUF2953"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11167">
        <property type="entry name" value="DUF2953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="235" mass="26642" checksum="850E50DE4540D789" modified="2018-12-05" version="1">MKGGRSMAFWLWTAIAAVLLAFSLAAMSRIRVRVRYSRSGELDQLIVIVRALYGLVHYRLNVPAILLSGWSVVYPQSSTSANPVRKSNKKAKRRVRFQTLRRYWAAYRIIMLSTRQFRRWLRHTLKKVECTRWRFDIRVGTGDAALTAATAGLCWTVLGCATAVTGHYLSLRTKPNGSVVPNFSRSEFSVVWEADFRIKAGTALAAGISLLFRTAKLRKSMKAWQSWLSGPERIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ21</accession>
    <name>A0A398CQ21_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01937">
        <property type="protein sequence ID" value="RIE01937"/>
        <property type="gene ID" value="D3H35_14280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="114" mass="12244" checksum="FA47C39307401EFF" modified="2018-12-05" version="1">MRVSRKQTVFTGVHDIFISRPINGANSIVITTDCGGAAEDGLPEKAIPDGTVVKLRRKAVSQFVSAFTDSGGECTQNTFDISPALARKFGIVNNTRYTVTTTAVHGRGRCAENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ54</accession>
    <name>A0A398CQ54_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01977">
        <property type="protein sequence ID" value="RIE01977"/>
        <property type="gene ID" value="D3H35_14500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="91" mass="9779" checksum="1C1F424D97044021" modified="2018-12-05" version="1">MVVRSVSPLCLTAATAKEDSEDSSKKQTAAAEKTVKKSGSSSAEKTSLAVADTKKAEAETPDAQADDKPKAKFFLWELLRQLLAFLKSLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ59</accession>
    <name>A0A398CQ59_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 11">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">UMP pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">UPRTase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">upp</name>
        <name evidence="12" type="ORF">D3H35_14560</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Allosterically activated by GTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="3 11"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01987">
        <property type="protein sequence ID" value="RIE01987"/>
        <property type="gene ID" value="D3H35_14560"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01218_B">
        <property type="entry name" value="Upp_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034332">
        <property type="entry name" value="Upp_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-phospho-alpha-D-ribose 1-diphosphate binding" evidence="11">
        <location>
            <begin position="131"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uracil binding" evidence="11">
        <location>
            <begin position="199"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE01987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="209" mass="22729" checksum="5F64F8D46D9D0C04" modified="2018-12-05" version="1">MGRLVICDHPLIQHKVTIIRDKTTNTKHFRELVDEVAMLMGYELTRDLPLEEVTVETPVSKAAGKTIAGRMVGLIPILRAGLGMVDGVLQLLPSAKVGHVGMYRDEETLQPVEYYVSLPTDVTERELIVIDPMLATGGSANAAISLLKKRGCRPTKLMCLIAAPEGVKAVQEAHPDVDIYLAALDEKLNEQGYIVPGLGDAGDRLYGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQB5</accession>
    <name>A0A398CQB5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_22495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01174">
        <property type="protein sequence ID" value="RIE01174"/>
        <property type="gene ID" value="D3H35_22495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039532">
        <property type="entry name" value="TetR_C_Firmicutes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14278">
        <property type="entry name" value="TetR_C_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="177" mass="21284" checksum="B33D8AF1E487180E" modified="2018-12-05" version="1">MNHVTERTRAHILQSFQSLLEDKGFEDISIKMVCEASKIHRSSFYRYYIDKYDLFEDLLRLITEELYVLIEEENQSFFEVFIDYVSSREKIARHLFDNNNETFNYFVKLASKLMLEQAKIQRSPFTKKINEAKFPEIVCDFYSSGIIQIIKKWLGRQYSMTKEELKNFIYDETKGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQD9</accession>
    <name>A0A398CQD9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Potassium:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01204">
        <property type="protein sequence ID" value="RIE01204"/>
        <property type="gene ID" value="D3H35_22670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026278">
        <property type="entry name" value="K(+)/H(+)_antiporter_KhtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005028">
        <property type="entry name" value="KhtT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK C-terminal" evidence="1">
        <location>
            <begin position="76"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="164" mass="18295" checksum="7B093AF21069039A" modified="2018-12-05" version="1">MNLREIDLPGIGKKFQMKTRGGDQLVVIVHEDGRRECYHFDHDDPDMSLSMITLDDDEARMVAAIIGGMTYKPRMLESIEVALDDLIIEWYKLESHYACVGKTIGELDLRKNTGATAIALIEANHAKHINPGPEIVLSAEATLVAVGERPQHKELKKILMNGCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQH0</accession>
    <name>A0A398CQH0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_07440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04410">
        <property type="protein sequence ID" value="RIE04410"/>
        <property type="gene ID" value="D3H35_07440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Condensation" evidence="4">
        <location>
            <begin position="10"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="3">
        <location>
            <begin position="272"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_25" evidence="5">
        <location>
            <begin position="465"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="3">
        <location>
            <begin position="672"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="817" mass="90497" checksum="DDB16069DFE7A570" modified="2018-12-05" version="1">MIENRLMTADGRETAKLYWSNHLSGELPRVALPGQKPQSSAYTRAEFRLNVPELLASRLTRIAKQNDLSMFAVLLAAGKAWISRLTGQEDIPVTVPVYSLTVPESEASNRRLVVRDRLSPEQSFRDTLSQVKMTLSECYRHQLFPLRQIEEELGYPGGKGMWSAIAFAMEDLHLAEHIGALADGSHEAAFVIGKREGELTVAVRYNGDIFHEEAIRSYAEGYLYATEQLLDHPDRAISEVRLTTEEEWSRIVHSFNDTKAPYSGDCTIHELFERQAAENPDHAAVISGGSTATYREMNDKANKLAALLRQTGIGPGSYVAVLTDRSVEMITAVLAILKAGGAYVPLDPGYPRTRIETILTSLPIRCIVTKASVMRPFQELTRKLPNLADVVYLDVPTERPGPEQVQEQRVRALWDRITEESFDWVTAGGFISSYDGQPFGEAEVAEYRDRVVSLARAAIGPDSSVLEIGCGSGLISFELAPLVSKYVGLDPSEKMLERNRATAEELGLQGTEWISGFAHDLEGQAEASYDLIVLASTAQFFPGYAYLENIVELALRCLKPGGTLLLADIMDLRKKDEFRESLEAYKKLHGTESRTRSVPDYELYCDEDFFYDLQADYGQIGEVGVLHRTEGFRNELGYRYDVVVKKAERVGESAVAPERAHAKRKTIWTAYHVDRQSAKELVSGAVPDNEAYVIFTSGSTGTPKGVVVRHKPVINVIEWVNRHHGVGPGDVLLFLTPLCFDLSVYDIFGTLAAGGTIRIASDDEAKDPERLLAILRSEPVTIWDSAPAALQQLVPYLRMNSAPSAAPAVRTDFVSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQY0</accession>
    <name>A0A398CQY0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhamnulokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_03345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000018">
        <property type="protein sequence ID" value="RIE04943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04943">
        <property type="protein sequence ID" value="RIE04943"/>
        <property type="gene ID" value="D3H35_03345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008993">
        <property type="term" value="F:rhamnulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07771">
        <property type="entry name" value="FGGY_RhuK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013449">
        <property type="entry name" value="Rhamnulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0684">Rhamnose metabolism</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="274"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="513" mass="56668" checksum="62E99A5DA3E71CE3" modified="2018-12-05" version="1">MTTILAYDLGASSGRAMLGRLTDNRIATEELHRFSNDPVRAAGRLHWDILRLLHELKQGLLKAKHKGEKLRSLAIDSWAVDFGFLGRGGELLGNPYHYRDAHTDGVMNKLFAEIPASEVFGRTGIQFLQFNSIFQLYAMAKAGNPILEQAEHFLMIPDLLRYFLTGEKHNEFTNATTTQLYNPISGGRHKDNGAAGGWDKGNRAAGGWDAELIRRIGAKPSWFGHVAQPGSVVGTLSASVMEELGVDAIPVLAVAEHDTGSAVAAVPALNRSFAYLSCGTWSLIGTEVDSPVIDERTQRFNFTNEGGAYGTYRLLKNIMGLWILNECRREWERAGLLYSFPELVKMAGEAAPFAAFIDPDDDLFLPPGDMPSRIRQYCDRTGQRAPDGPGAIVRCILESLALKYRYALGLTETLSGQRFDGLHMVGGGIHNTLLCRWTANAIGKPVWAGPDEGSAIGNLIVQWIAQGEFSDIWEARRTIRDSFPVTVYEPEASEMWEDAYGRFLRATRLEAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQY3</accession>
    <name>A0A398CQY3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01344">
        <property type="protein sequence ID" value="RIE01344"/>
        <property type="gene ID" value="D3H35_23515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="200" mass="22118" checksum="760E8C089F4CA1C6" modified="2018-12-05" version="1">MFHKVRFPFHLPDRAKFCYNKTASFPPICQIFFAVSTTHDAIDKMFYNGIVIAFKGAATMVLQRIRNEQGTTLIQVLGATIILTMIILAFVSLSQFTTASNKDTDRRDQALLIAEQIVNEIRASTTTTYTTGNLTPWSDNTYSYKIIKTALTNGNEPSLSAKIITESGVSVRNQVSVQSIMLDGTGTVPQLLTVNVSWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR53</accession>
    <name>A0A398CR53_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">rsmA</name>
        <name evidence="6" type="synonym">ksgA</name>
        <name evidence="9" type="ORF">D3H35_23840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01404">
        <property type="protein sequence ID" value="RIE01404"/>
        <property type="gene ID" value="D3H35_23840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="8">
        <location>
            <begin position="48"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="304" mass="33026" checksum="AAA2414DA7D9CB54" modified="2018-12-05" version="1">MNKKASGQAGKGEAVGIAASGRTRDIIRKHGFTFKKSLGQNFLIDQNVLDRIIEAAGLDETRGALEIGPGIGALTERLAQAAGKVAAVEIDRRLIPILQDVLSPYENVSVVQADVLKTDLHELWEQKFAGCEKVSVVANLPYYVTTPIIMKLLEENLPVEHIVVMVQKEVAERMAASPGGKEYGSLSIAVQYYCEPQIVCKVPSGAFIPAPNVDSAVIKLTRRDKPPVEVRSAELFFKIVQTSFAQRRKTISNNLTALSGKERKAELADLLRGCGVEPERRAETLSLTEFASVTEALANAGMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR71</accession>
    <name>A0A398CR71_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_02535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05033">
        <property type="protein sequence ID" value="RIE05033"/>
        <property type="gene ID" value="D3H35_02535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="315" mass="34279" checksum="247CC4E5A0AD6F18" modified="2018-12-05" version="1">MLAFVGKRCFYLLIVLFILSVVVFSIIYLIPGDPALALLGDTATPEMLEALRSDMGLHRSVVEQYGLWIVQLLQGDLGQSYALKQPVWDAIIERLSPTLSIAVLAQGIAIVIAIPLGLFAASRPGTAADRTVRGFTLLGMTVPSFLLGLFMMLLFAVQLKWLPVSGYKPVSAGFGLYLKHLIMPSVALGIIHSALLSRITRSAMLEVLGESYIRTARAKGVRESRIVYWHGLRNALMPIVTVIGQSFGALIAGAAVVESIFNIPGLGQLLVNSVQRRDYAVIQGVVLFVATLTVLLNLLVDLLYAVIDPRVRLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR78</accession>
    <name>A0A398CR78_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05043">
        <property type="protein sequence ID" value="RIE05043"/>
        <property type="gene ID" value="D3H35_02590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="161" mass="17612" checksum="497BF921AA902005" modified="2018-12-05" version="1">MVYRIHLALNVADVGKSVAFYRRLLGSEPDKQSDAFAKFEPVDTAINVALIQAKPVDTVNNDAGLVQAAPVDTASSTGLFQVEPAPAREPKKGELNHLGLQVRNAEEVREAARRLKEAGLDPIPDRSLSGEERILLYDPDGNEWEVFYATAALNVDRSGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRG6</accession>
    <name>A0A398CRG6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="5">4.1.2.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Queuosine biosynthesis protein QueD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_24430</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.50" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01504">
        <property type="protein sequence ID" value="RIE01504"/>
        <property type="gene ID" value="D3H35_24430"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070497">
        <property type="term" value="F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE01504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="159" mass="18130" checksum="E30FB7B9B0AE6F7B" modified="2018-12-05" version="1">MMQQIYPTVPHPYQYELNKDLHFAAAHYIPTEKAGVCSQVHGHTYFANVTIAGNELDDSGFLVNFADIKRLIHDRFDHSVLNDHAPWFGDDTPYRYPTTENAARVLSEIVQEHLDRLPNRPLCVQVYLRETPTSYVVYRPRFEASASSARDGAGEAHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRJ7</accession>
    <name>A0A398CRJ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_24590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01534">
        <property type="protein sequence ID" value="RIE01534"/>
        <property type="gene ID" value="D3H35_24590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="188" mass="21323" checksum="E3154C08222C73CA" modified="2018-12-05" version="1">MGRKQAYTQAELLDTTKRLLLEHGYDGFHLKLLSRHLHGARSTIYQYYGNKEQIVAACMKSVMMNMLESASLVDESDCMKALEQVLRIYIQESAFHQLLGSINKINTADAPSAAEDLAFVEQSHITLKDQLSRLFARAQQQGALRKDVPLPILIGVFFNFINTPNMLGIPTAQWSRHLFDIWLNGARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRJ8</accession>
    <name>A0A398CRJ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycine oxidase ThiO</fullName>
            <ecNumber evidence="3">1.4.3.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">thiO</name>
        <name evidence="3" type="ORF">D3H35_17310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.19" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02457">
        <property type="protein sequence ID" value="RIE02457"/>
        <property type="gene ID" value="D3H35_17310"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043799">
        <property type="term" value="F:glycine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012727">
        <property type="entry name" value="Gly_oxidase_ThiO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02352">
        <property type="entry name" value="thiamin_ThiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="2">
        <location>
            <begin position="5"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="370" mass="40863" checksum="A5BE0075ECB4FC2C" modified="2018-12-05" version="1">MKESIVVMGGGVVGLSCAFELQRRGHQVTVLEINRCGGQASGAAAGMLAPYSENVEGPDAFFQLCLESLRLYPEWQQNVKQASGQTFEYTNSGSLYIAYHEADLLALEGRLLWQGQYGSSGKIIEGDALFRLEPNLSRNVRAALHTPEESHVYAPHYVRALEQACRLMGVTIHENLDKLTIVEWQREILIQSTDQRMFSGDQLVVCSGAWAQELSDTFGIRIPVYPIRGQICAYEVDEKPVHHMVFGNQGYLVAKENSTLVCGASEDVAGFDTSVTDKGIERLRKWNKQAFPFLEDRTPFHRWAGLRPSTQDGLPLIGALSGSSRVVFAVGHYRNGILLSPATAMLAADCIEGKNTAAYNQAFSPERFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRX1</accession>
    <name>A0A398CRX1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_00710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05345">
        <property type="protein sequence ID" value="RIE05345"/>
        <property type="gene ID" value="D3H35_00710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="471" mass="51151" checksum="1EBB6675699D694E" modified="2018-12-05" version="1">MIVAIEIRMLLASRYQGFISDQGLFIHWMETIRQYGLGEAYIQNGSINYPPLFLMLMDGYGKVLSLFGTSALIGTLSFKGIVVLVDFAAMLAAIKLSAGIRSSGWRLFILALFALNPVLIAGGAVWGQIDMLHSLLMVLAIVSLTKKTWLSGVWAALALLTKFQAVTILPIIGIYLLIEAFRNRRWKPSIGWLGGFAVPWLVTVGYFASAGGLKEMIKLAYTDAVGMYTSATVNAANIWFHVVGIDPSSDDTTPFLLGMSLRTFSLLLFAAAALFICVYEWIATRSGDIEAVLLKASCAMGFAFFMLPTEIHERYGIPALVFALFVVLHDRRWLVAAVGMSVTMLVNILVVMQDAASGRFGGRGNGDGLGRRGFGSGRGFENGGGLGNGRGPGSGSDFGADTPFGSGRSPIGGGPGTTMAASYTWIAVVNVLLLIWLLWVMWYEMRQVRQVRQLKELADQEMGQPRQVGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS37</accession>
    <name>A0A398CS37_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000006">
        <property type="protein sequence ID" value="RIE05415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05415">
        <property type="protein sequence ID" value="RIE05415"/>
        <property type="gene ID" value="D3H35_00570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="77" mass="8707" checksum="28C78B4068BD3959" modified="2018-12-05" version="1">MSNRSWAFIVFRTRPRGKRLPWHIRQIAEIGYKNVELAGYYGVSAKDLKQALADNGLHASSAHVGLTVNEPEKLEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS53</accession>
    <name>A0A398CS53_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamine synthetase</fullName>
            <ecNumber evidence="4">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glnA</name>
        <name evidence="6" type="ORF">D3H35_08905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04059">
        <property type="protein sequence ID" value="RIE04059"/>
        <property type="gene ID" value="D3H35_08905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="5">
        <location>
            <begin position="101"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="2">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="474" mass="52617" checksum="0BE49E6595E39F77" modified="2018-12-05" version="1">MSVEKVLDLLKEKNIEFVDFRFISLAGQAHHITLPTTEVDADTFVNGVAFDGSSIPGFRGIEESDMVMMPDTETAYVDPFTAHSTLIIMCNIHTPDGERYERDPRSIAHKAEEYLQKAGVGTTAFFAPESEFFIFDDVRYESTMNSSSFSVDSEEAAWNTNRKEEGGNLGFKVRVKGGYVPVAPTDSQQDIRSEMVRIMQETGLRVERHHHEVATAGQAEINFRFDTLTTTADNLMKYKYIIHNVARQYGKVATFMPKPLFGDNGSGMHVHQSIFDGGEPLFYEKGGYGNLSQMALYYIGGILHHAPALIAITNPSTNSFKRLVPGYEAPVNLVYSKGNRSAAVRIPVAAVTPKGCRIEFRTPDSTANPYLAFAAMLMAGLDGIKRKIDPAALGYGPFDTNIYELSDEQKKEIRSVPGTLDEALDALEADSEFLTEGGVFTKEFIDNYVALKRGEAKAVSIRVHPHEYSLYFDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSB4</accession>
    <name>A0A398CSB4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0316 protein D3H35_13665</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_13665</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cell membrane</location>
            <topology evidence="2 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UPF0316 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01834">
        <property type="protein sequence ID" value="RIE01834"/>
        <property type="gene ID" value="D3H35_13665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01515">
        <property type="entry name" value="UPF0316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044035">
        <property type="entry name" value="DUF5698"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022930">
        <property type="entry name" value="UPF0316"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40060">
        <property type="entry name" value="PTHR40060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18955">
        <property type="entry name" value="DUF5698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5698" evidence="9">
        <location>
            <begin position="22"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE01834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="175" mass="19949" checksum="C93ECCEA5F3B49C7" modified="2018-12-05" version="1">MNGLQTILTIVLMNVVYVSLFTIRIILVMKARRLLASLISTFEVFVYLMALNIVLKNIDDPLNLAAYCIGWGGGVWLGIKIEEWLALGYITLQIVVESGSNRLPVLLRERGFGVTNWLAEGKDGPRLVMEVLTKRNQEKYFMRILNEVAPKAFVISYEPRAFRGGFWTKRLKNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSD9</accession>
    <name>A0A398CSD9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03658">
        <property type="protein sequence ID" value="RIE03658"/>
        <property type="gene ID" value="D3H35_10180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="1">
        <location>
            <begin position="20"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="289" mass="31213" checksum="CAE3A9B2283586C2" modified="2018-12-05" version="1">MANATATELKLKAIQIRQDLLRLIHDAKMGHTGGSLSNTDVLTALYYGVMRHDPARPKWEDRDRFIASKGHSVESLWCILADLGYFPKAELSTYCQFGTRLIGHPNNKVPGIEMNTGALGHGLSVSVGMALAAKKDNRPYRVFCIMGDGEQAEGSVWEAAMAGAHYRLDNLVGIIDRNRLQISGTTENVMGLDPLDSKWEAFGWNVVSIDGHDYDELLHTFESAPAQPGKPTLVIANTVKGKGVSFAENVPAWHHHVPNDAELAQAIEELTAAASALEATAAKGSGTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSF9</accession>
    <name>A0A398CSF9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine-binding chemotaxis protein CheW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02311">
        <property type="protein sequence ID" value="RIE02311"/>
        <property type="gene ID" value="D3H35_16450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="142" mass="15657" checksum="7B14EA1D38EDA6C7" modified="2018-12-05" version="1">MNGSDQDQYVEFSLGREKYAILISEIHEIIRMQDITQVPSSPRYVRGVINLRGKIVPVISLRSLLSLAEENASKATRIVVVNHREESVGIIVDNVNKVVRFSDIQPPPDRVGGISGVFFAGIGFSGEDLVGILRLGEVLLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSR1</accession>
    <name>A0A398CSR1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02847">
        <property type="protein sequence ID" value="RIE02847"/>
        <property type="gene ID" value="D3H35_19655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010288">
        <property type="entry name" value="EcsB_ABC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05975">
        <property type="entry name" value="EcsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="426" mass="46503" checksum="96CEAB56D30A27CF" modified="2018-12-05" version="1">MRKEAPSVPERRQEGNIGRIRQERAAAFRKEIFPYFRYVAQSGFGLVASAIAFSLLIGYVKLLRGVPESWPADWVGAACLLLAAFPTPLRTYLMPADSIFLLPMETNIYRHYLRPSIHKAIVKGTVRTAAMFAVYAPVYAAAPVTEKAADSRSLGLLAVMFAALGAWNAIAGWRERTLASSGLRLAVRSGRFAITAGAVFGLLLGPIVPAVIFAIAGAALCSACWRLGASHYVPWDRLIQEESAARRRWFRFLAWFVDVPEAPSRPVRRPWAAWVGKLVAWERRKAWTYLYTLTYIRGETFGAFYRLCLMAAFVLVAAQGIVVDTVILAVAVLAGGMQLSELGRLRAGENAFVAPLPQEGKASAAAFVGRVAGLAAAVFLSIAAFLPSAAENPLLAIVTVAACLGWMGWRVPRTISKRARNEDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT03</accession>
    <name>A0A398CT03_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">DNA-directed RNA polymerase subunit omega</fullName>
            <shortName evidence="10">RNAP omega subunit</shortName>
            <ecNumber evidence="2 10">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RNA polymerase omega subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 10">Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpoZ</name>
        <name evidence="11" type="ORF">D3H35_07320</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 10"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04389">
        <property type="protein sequence ID" value="RIE04389"/>
        <property type="gene ID" value="D3H35_07320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00366">
        <property type="entry name" value="RNApol_bact_RpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003716">
        <property type="entry name" value="DNA-dir_RNA_pol_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34476">
        <property type="entry name" value="PTHR34476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00690">
        <property type="entry name" value="rpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 10 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE04389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="66" mass="7510" checksum="D1DBE0EAEF2A4DD9" modified="2018-12-05" version="1">MLYPSIDELVRKVDSKYTLVVAASKRARHLREGKESALHAPKSHKFVGVALEEIYDDFVTVEHLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT05</accession>
    <name>A0A398CT05_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M56 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02451">
        <property type="protein sequence ID" value="RIE02451"/>
        <property type="gene ID" value="D3H35_17255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008756">
        <property type="entry name" value="Peptidase_M56"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05569">
        <property type="entry name" value="Peptidase_M56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M56" evidence="1">
        <location>
            <begin position="3"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="96" mass="11019" checksum="70EFB73B69D47D73" modified="2018-12-05" version="1">MRFILLHELQHWKTRDSCLHLAANLVQHVHWFNPLVHTASKRNRRQSRGCHVQAMPCSVLNTRYPLSYGPHAIPQAVHLCLASSPGDERAIGLFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTQ0</accession>
    <name>A0A398CTQ0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_09090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04088">
        <property type="protein sequence ID" value="RIE04088"/>
        <property type="gene ID" value="D3H35_09090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="50"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="408" mass="44863" checksum="D468CE36CF9CF00B" modified="2018-12-05" version="1">MIKDEERPKTLTEQPRKKEMQDYLSAQARAIPPSGIRRFFDLVSNSKDKDIISLGVGEPDFVTPWRVRDAAVYALEKGKTQYTPNAGTPELREAIGQYLSDRFQVVYNPANEILVTVGGSEGIDLALRALIEQGDEILIPEPCYISYSPITTIGGGVAVGIETSAKDEFKLTAESLRAAITPRSKILVLCYPSNPTGAIMTYEEMLPIAKLVEEHDLIVISDEIYAELTYGAKHVSFASLPGMKDRTILVSGFSKAFAMTGWRMGYACGHPDLIGAMLKIHQYTVMCAPIMGQVAALESLTSGGLEEKDRMVESYNQRRRLIVQGFRDIGLACHEPQGAFYAFPSIQSTGLSSEEFSQRLVQEAKVAAVPGHVFGKGGEGFVRCTYANSVAQLNEALERIGNFVYKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU09</accession>
    <name>A0A398CU09_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04759">
        <property type="protein sequence ID" value="RIE04759"/>
        <property type="gene ID" value="D3H35_04575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008990">
        <property type="term" value="F:rRNA (guanine-N2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007536">
        <property type="entry name" value="16SrRNA_methylTrfase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36112">
        <property type="entry name" value="PTHR36112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04445">
        <property type="entry name" value="SAM_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="259" mass="28412" checksum="46041DF67999BD97" modified="2018-12-05" version="1">MIVTTAERPSAVLLARAEALAKELGADCVPRRNETLRGMERIYGDDGVLVVSEGGLRYVREDDSPLFFHPSMGLVRIKRLRDGGTDVMIDVSGAQPGDRVLDCTAGLCSDAIVFSYAVGAEGSVTALEASKLLHVIVREGLGEHDTGLEDVNAALRSVEPVLGNHEQWLRGMEDRSVDIVYFDPMFQRPVTTSTSLRPLRGHAHHGTISEETVKHAVRVARKAVVLKDHRDSGEFRRLGFTVPRKTTKAVNYGVIRTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUR2</accession>
    <name>A0A398CUR2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pseudouridine-5'-phosphate glycosidase</fullName>
            <shortName evidence="6">PsiMP glycosidase</shortName>
            <ecNumber evidence="6">4.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">psuG</name>
        <name evidence="7" type="ORF">D3H35_20790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-ribose 5-phosphate + uracil = H2O + psi-UMP</text>
            <dbReference type="Rhea" id="RHEA:18337"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:58380"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="4.2.1.70"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the pseudouridine-5'-phosphate glycosidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.70" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03031">
        <property type="protein sequence ID" value="RIE03031"/>
        <property type="gene ID" value="D3H35_20790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046113">
        <property type="term" value="P:nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="PTHR42909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="SSF110581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="142"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="306" mass="32533" checksum="1FCFAE1096102672" modified="2018-12-05" version="1">MNATSYLTFTEEVREALQTGKPIVALETTIISHGMPYPQNIEMAKTVERIIRDNGAVPATIGIMNGKIKIGLNDEELEAFASNGHVEKVSRRDFPQLLASGQIGATTVAATMIGAALAGIRVFATGGIGGVHRDGETTMDVSADLTELAQTDVAVVCAGVKSILDIGRTLEYLETHGVPVVGYKTDEFPSFYSRESGFGVDFRIDTPEEAAVMLRTKWALGLKGGAVIANPVPEASAQKHSEMEDVIGQALREANERSITGKKVTPFLLGRIKELTGGSSLETNIALVYHNAEVAAKIAVALHAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUY6</accession>
    <name>A0A398CUY6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmI</name>
        <name evidence="6" type="ORF">D3H35_10280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03677">
        <property type="protein sequence ID" value="RIE03677"/>
        <property type="gene ID" value="D3H35_10280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="66" mass="7464" checksum="A67331B9FF96237D" modified="2018-12-05" version="1">MPKMKTHSSLKDRFKVTGTGKVKRNKAYKNHLLSHKSGRQKRVLGAPALLAKGDVRRLQQQLANLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV28</accession>
    <name>A0A398CV28_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_10020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000031">
        <property type="protein sequence ID" value="RIE03737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03737">
        <property type="protein sequence ID" value="RIE03737"/>
        <property type="gene ID" value="D3H35_10020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="247" mass="27413" checksum="DEA1E861D450C92F" modified="2018-12-05" version="1">MPETGDISNTRISLVYDKKLVNESVRKELDRRLSAADLKLVQAAGELGKKIAGSKRPLFPLTLVTERPDRITMLLKRGKIVIVIDGSRFALVLPVCFSDFMHAMDDEYEMFWMSRALLLLRYLSLFLTLTLPAAYISIVSYNPEIFRVQLTLSIAGSRLVVPYPSFIEVFIMLFMIEALTEASLRLPRYIGSTAATVGGLILGQAVQQAGLVSSIMIIVTSVVAISNFVIPKKIAAATKMYFANRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVE0</accession>
    <name>A0A398CVE0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable transaldolase</fullName>
            <ecNumber evidence="9">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fsa</name>
        <name evidence="9" type="synonym">tal</name>
        <name evidence="10" type="ORF">D3H35_01740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the transaldolase family. Type 3B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="9"/>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05269">
        <property type="protein sequence ID" value="RIE05269"/>
        <property type="gene ID" value="D3H35_01740"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00956">
        <property type="entry name" value="Transaldolase_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00494">
        <property type="entry name" value="Transaldolase_3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022999">
        <property type="entry name" value="Transaldolase_3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004731">
        <property type="entry name" value="Transaldolase_3B/F6P_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033919">
        <property type="entry name" value="TSA/FSA_arc/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00875">
        <property type="entry name" value="fsa_talC_mipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE05269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="221" mass="24167" checksum="3C8986F8ADB2B969" modified="2018-12-05" version="1">MKFFIDTANLADIKKAYQIGVLSGVTTNPSLVAKEGVKFEDRIEEILKEVPEVESVSAEVTPDAVTAEEMISQANELIKINNYDKNITIKLPMTLAGLEACRYLTKKGVKTNVTLIFTVNQALLAARAGATYVSPFLGRLDDISEDGVQLIVKVAELFRIHNLDAQIIAASVRHPDHVTRVAMAGAHIATVPFAVIEQISKHPLTDQGLEKFAADWKKAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVJ3</accession>
    <name>A0A398CVJ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4227 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04548">
        <property type="protein sequence ID" value="RIE04548"/>
        <property type="gene ID" value="D3H35_05495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025321">
        <property type="entry name" value="DUF4227"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14004">
        <property type="entry name" value="DUF4227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="77" mass="9111" checksum="4FF2F3B8D67C71A8" modified="2018-12-05" version="1">MEEQRGKWWERLQFTLLFLVLTIVLHSLLGWFQVWLKPADPYRVPQGRAAKVFMTGEPGELNGSPGDRLRLFFWYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVL9</accession>
    <name>A0A398CVL9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable transcriptional regulatory protein D3H35_20995</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_20995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TACO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03064">
        <property type="protein sequence ID" value="RIE03064"/>
        <property type="gene ID" value="D3H35_20995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="247" mass="27103" checksum="7618B35D4041F359" modified="2018-12-05" version="1">MPKFKLFAGRKGKADQAKNNKYVKLAREIYVQARKGGTNPDANAGLKTAIASARAIQMPNDNIERAIKKAAGGTDSVDYEEILYEGYGPGGVAIMVKCLTDNRNRTAADVRAVFNKRGGNLGESGCVSYMFDEKGLLVVSREDFDRDEDTVMMEALEAGAEDVVATEESFEVLTAPADFLNVKAALEQAGYSFESANIRWLAPNTIVSEGDNADKLLKMMEAFDDNDDVQDVYHNFEISDEEMDRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVY8</accession>
    <name>A0A398CVY8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03184">
        <property type="protein sequence ID" value="RIE03184"/>
        <property type="gene ID" value="D3H35_18330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="100" mass="11066" checksum="D047DCC65F29A7FC" modified="2018-12-05" version="1">MIRTKLTKPVSVRQAPIFPRLTVVWVQINGVPFNTTGFFARLSRGGVLVDTARFDRNGVVRFNVATLTRVAFTLRVFSASGILFRTRIIPAGVETFAIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW68</accession>
    <name>A0A398CW68_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD_binding_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_11190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03264">
        <property type="protein sequence ID" value="RIE03264"/>
        <property type="gene ID" value="D3H35_11190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_5" evidence="2">
        <location>
            <begin position="35"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="168" mass="18253" checksum="CF43F329DFCD5F55" modified="2018-12-05" version="1">MAAAFVIPKYGDRPIRRRHGNGSAGSARKRRSRPGATWLRTQWEAGSLPMPSYLIDLSAVKELTGIKVKHNRLTIGALTSLAQVRSSAEVLANAPALTAAAAAIAAHSIRQLATIGGNIVTRVGDSLPGLSLTKRSWFGKMTKENARWMRSRGWNVAEAERQGFVHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWA2</accession>
    <name>A0A398CWA2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03491">
        <property type="protein sequence ID" value="RIE03491"/>
        <property type="gene ID" value="D3H35_12650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="495" mass="56637" checksum="F832D966835C3BFF" modified="2018-12-05" version="1">MLMWDKPEVVEGLTVYRDHEDRTLYYVLPSVPGFRIDDNGLPVFKFIKYRFPIDRPDGKKGGGFLIADVEFSVPEDKLAKVKEALQERLDEQARNLGQQTPASPVKFGQLSFLRGTASITVLDDGGSLVEKVINPAAPSLYGKMITPFTAELSAEGATLLEQALQGKGAIVQVAYDLWMPVRLPPVKARIWFKAEKFMEFHQEIDVEENFWSEDDYREKISEKFSQREAGGVQIDPGGVVDQKVIGAVRDWALRNWEDRLAKMVLGDIPPVDRDASKWYTEHDFENISRDVISSRVSSFDIKYEEGSIMEWNPSPRGSLPNITTLTGRDGQPFKWEDFSLTVDLDDPFFRQLRVTTRANADFDKLPLNSVEVKIEYKQGAEHSIKEFDLRSPDDLGKFASFIANDSYKYKYSYQVNYKGSPGLSIARNRKRRRKFDDQRRRHRHSARGCSPGDLNFNQVSEAQVTLQYEDRDNGVDLIEDVFKLDKDHSEHVFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXB0</accession>
    <name>A0A398CXB0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1775 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_10045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03634">
        <property type="protein sequence ID" value="RIE03634"/>
        <property type="gene ID" value="D3H35_10045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08545">
        <property type="entry name" value="YcnI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012533">
        <property type="entry name" value="YcnI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038507">
        <property type="entry name" value="YcnI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07987">
        <property type="entry name" value="DUF1775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017379691" evidence="3">
        <location>
            <begin position="24"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1775" evidence="4">
        <location>
            <begin position="24"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="211" mass="22088" checksum="12BF37614DF36E32" modified="2018-12-05" version="1">MKKSLVVLLVLLFTIAGAGLASAHVTVQPQEVAAGSYQVFTLRVPTEKDVATTQVKIEVPAEVTVSRFEPKSDWTYDLEKDADGKIVSVTWKSTGKGLSATEFGQFLFQGKVADEAKELVWKSYQTYADNSVVEWTGAADAEKPASVTTVTAKVEGSDGHGAAGSASGAAHDDGDNGSDRDTLTLSLAIAGLAAGVLALLVALFRRGGKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY72</accession>
    <name>A0A398CY72_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sporulation integral membrane protein YtvI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ytvI</name>
        <name evidence="7" type="ORF">D3H35_08240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03944">
        <property type="protein sequence ID" value="RIE03944"/>
        <property type="gene ID" value="D3H35_08240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014227">
        <property type="entry name" value="YtvI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02872">
        <property type="entry name" value="spore_ytvI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="344" mass="37473" checksum="B7CA0FB8F43BF93B" modified="2018-12-05" version="1">MPMRIVLTMAFVLVFLYLLFTVGAPFLLALVVAIFLEPLTQLMMQKLRMNRLAASTVSSTVFTVMLLGLLSLIGMKVVNELKAFMDNVPTYLKNANDYIKDMLEKAQSYSSDGSDPVPGQLEGWLSKATEALTNLSQTIVKYVGSFASGIPDFFIFLIVFLVAVYLFTLSLPMMKESFLSLFEDESRGKMDQVLASLRKSVFGFLRAQLLLSVVTYIISFVGLLIIGTGYPLAIALLIVVVDILPVLGTGSVLVPWAAYLFVTGDIFTAVGLILLFLVITVVRRIIEPKILGDAVGIGALSALISLYVGYALVGVIGVFLGPIVVIVFMAARKAGLLDFKIKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYK7</accession>
    <name>A0A398CYK7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Copper amine oxidase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_06790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04311">
        <property type="protein sequence ID" value="RIE04311"/>
        <property type="gene ID" value="D3H35_06790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017450573" evidence="2">
        <location>
            <begin position="31"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="3">
        <location>
            <begin position="65"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="325" mass="34383" checksum="BF2A3E10F3EBDE02" modified="2018-12-05" version="1">MNKTAWKRKGIAALLFAALGLSLLANTAGAAAKTTQVNVQTKAVQLVFDGKTLSLPTGQHVFSINGTNYVPVRFISYALQKNVGWNDKTKTVTVSDPTKPEAVMLNEFLMNLAGEAGKPSSKGGLKLLVTPVQAKFVFDGSSKSLPKGQSAYNVNGSIYVPIRFMSESIGTDIGWDGKSGRITAVSPAYKKEQEAAGAENGEGDGKEETSTGGTATGGGSSGSAKPTLESITASTEARLHTLESSCQNTLMNIALSAFGQSAEEKAKIRTQGQKALDQCKAQFETIVTNAENQLTTNGYSTAIIAEYRKYFQEQLDAGKAIFDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ99</accession>
    <name>A0A398CZ99_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ferredoxin--NADP reductase</fullName>
            <shortName evidence="2">FNR</shortName>
            <shortName evidence="2">Fd-NADP(+) reductase</shortName>
            <ecNumber evidence="2">1.18.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_02065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:20125"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferredoxin--NADP reductase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05177">
        <property type="protein sequence ID" value="RIE05177"/>
        <property type="gene ID" value="D3H35_02065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01685">
        <property type="entry name" value="FENR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022890">
        <property type="entry name" value="Fd--NADP_Rdtase_type_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="6"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="351" mass="38812" checksum="1F3FE23BEE95A7B1" modified="2018-12-05" version="1">MNTELYDVTIIGGGPAGLFSAFYSGLRGMKTKIIEFQPYLGGKVNVYPEKMIWDVGGLTPIPGAALIEQMVQQGLTFDPDVVLGEKVTSINKNEDGLFVIRTATSQTHFSKTVILAIGGGIIKPIKLEVEGAERFEVGNLHYVVKSLERFKERTVLISGGGNSAVDWANELEPIAKKVYLTYRKDMLKGHEADVARLFDSSVECLLNTTIDKLIAGENHENIEKVELVDSEAGARTVLKVDDVIINHGYERDKELTSKNNLNIKMKDEYFIDGNPMSETSVPGLFAAGDILHHEGKLHLIAGAFQDAANAVNKAKQYIEPGAEETGRVSSHHEIFKERNQKLVKHLYEQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZA7</accession>
    <name>A0A398CZA7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Cell division protein FtsA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">ftsA</name>
        <name evidence="8" type="ORF">D3H35_06515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Self-interacts. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="5">Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04264">
        <property type="protein sequence ID" value="RIE04264"/>
        <property type="gene ID" value="D3H35_06515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02033">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020823">
        <property type="entry name" value="Cell_div_FtsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003494">
        <property type="entry name" value="SHS2_FtsA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02491">
        <property type="entry name" value="SHS2_FTSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003101">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00842">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01174">
        <property type="entry name" value="ftsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsA" evidence="7">
        <location>
            <begin position="7"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR003101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="414" mass="44388" checksum="920C9424C6C04A21" modified="2018-12-05" version="1">MSSNDLIVSLDIGTSKIRVIIGEVSNGAINIIGVGSADSEGIRKGAIVDIDQTVQSIRSAIDHAERMVGISIGEVYVGIAGNHIALQTNHGVVAVSNEDREIGEEDIERVLQAARVVALPPEREIIGLLPKQFLVDGLADIQDPRGMIGVRLEVECTIITGTKAAVHNLMRCVEKAGLRISGIVLMSLASGMMALTKDEKQMGTVLADIGAGSTTIAVFEGGSLAAVSTLPIGGDYVTSDICYGLKTQTEHAEKIKLKYGCARIDDAADDQKFKVMRVGSNVEKEFSQLDLANIIEPRMQEIFQMIRQEVKRLGYHEKINGYVLTGGSVSMPSVLPLAQSELESNVRIAVPDYIGVRDPSFSSGVGMIQYVTKYVRTRGAVAAKRAPKTKAASGGGASKPGIVEWFKNMFKEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZF1</accession>
    <name>A0A398CZF1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_01570</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. EmrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05237">
        <property type="protein sequence ID" value="RIE05237"/>
        <property type="gene ID" value="D3H35_01570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="10">
        <location>
            <begin position="25"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE05237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="498" mass="52907" checksum="9BC85B901A59E66D" modified="2018-12-05" version="1">MSAPTQTKQMAAGEDNFSLKAILPPLLAIIVGMIMVILDSTVVNNAIPKLVEYFDTDLKTIQWTVTGYTLALSAVIPLAGWMTDKFGSKQIFMITIALFTIGSVLCGIAQTPEQLIAFRIIQGLGGGMVAPIGMAMVFKLAPPERRGSIMGVLGIPMLMAPAFGPVLSGWLVDSVSWHWIFIINLPIGIIAFILGYKYLPKSDRHAAPHLDIIGMCLAPIAFSMLAYGVSEGGTSWSQVSTITGLTVGGIALILFIFVELSQKQPLLELKVFKSSDFTRSIILAWIVQLALFGAMLIVPLYLQGVMHYTALETGWILMPQALCAGIGMPISGRLFDKIGARPLAFAGLTAVSISLFILSGISVDTSLWVIVLSICIMGLGMGFSMMPLNTHVLNSAPRRLVSRVTPLTTAAQQVVVSFAVAGLTGYLTSQITSHAASAGADANPLNAVVAGYGDTFFLSACIATTGVALSLLLRKPKQKEEDGTVGGDNPDPAMMMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZI4</accession>
    <name>A0A398CZI4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_03770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04621">
        <property type="protein sequence ID" value="RIE04621"/>
        <property type="gene ID" value="D3H35_03770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009926">
        <property type="entry name" value="T3SS_YcgR_PilZN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12945">
        <property type="entry name" value="YcgR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="T3SS_YcgR_PilZN" evidence="2">
        <location>
            <begin position="4"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="102"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="217" mass="25190" checksum="28DC0407CD0C389E" modified="2018-12-05" version="1">MLPKINQMLFLQALPDSEGIESVTFRSRVADQDERTIFIEIPLDEKSRRYHRCHVGEPFRVYFFTQEGVKHIFETEVTGVRKDTVSMVAIRKPALEDISRDQRRSFLRVEAALELAVRFDDKLRFVAITDDVGGGGLSFRCDRKWPIVNGAVLSCWLLVPYKGGTIAHAKFEGEIVRVLPVEPDKHLVMMRFSDIQDSDQQKIIRYCFERQLDNRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D066</accession>
    <name>A0A398D066_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_05195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04861">
        <property type="protein sequence ID" value="RIE04861"/>
        <property type="gene ID" value="D3H35_05195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017202193" evidence="2">
        <location>
            <begin position="48"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="471" mass="51776" checksum="5D97D5C4082EB914" modified="2018-12-05" version="1">MGKQRNSLTTGGGRMSIRKARAAKWMGSLLAISLVFAGCSNGNKEEASPTSSQTDGSGGSGTEIDWKTVKADIRFVYPGTSESEKLFAENFKTAMKEKYPNVNIEYMYLSWADMEKKISVMISTGDVPDIATTQDVTNFVQMDGLEDLTPYMQRETTSVKPDNFLPGTLDYSTIDGKIYAAPATANAFNLMVNEKMLNDAGMKLEELQTWEDVEKAAQLMTKDGKYGFGYPLGVARFAFRVPFTAGYSNDLLLSDTSETSKAKYIELLNHFKKLEAFQPKAHLTWGYPEMFRAYSNGEVGMIPAGTFFSANVYSINPDIINVSRAISYPKGPSGSAAKTPVANSGFGIYKGSKNKEVAWRLIEELLSPEFNSTQAAILNISAEKATSLDEVIKKAEDVYPKAIDGHKRVIEDFLAMVDKSGVPMNTIVGQPEMETVVQDIMVKFLTNKLDAEEAYGEIKKGIDSVTAKYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D2X0</accession>
    <name>A0A398D2X0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_00440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000005">
        <property type="protein sequence ID" value="RIE05434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05434">
        <property type="protein sequence ID" value="RIE05434"/>
        <property type="gene ID" value="D3H35_00440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="116" mass="13203" checksum="1B131C22D30797C3" modified="2018-12-05" version="1">MFYLVVFCIPLSIGSSALIIPNYLYMSELGFLNEWYTLPILYTAYNLPMAIWIIKSGVETIPVEVDEAATIDGASRSYIIFGMMSVLCRPALARRRIIILLFGCMERIYTSSIHHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CB16</accession>
    <name>A0A398CB16_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_29145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000057">
        <property type="protein sequence ID" value="RIE00336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00336">
        <property type="protein sequence ID" value="RIE00336"/>
        <property type="gene ID" value="D3H35_29145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="78" mass="8960" checksum="6D93814F1DBAD3CC" modified="2018-12-05" version="1">MLKMIIVDDEPLIREGLKSMPWERWGCMVAGEAEDGEDGLALVEETRPHFIITTFGCLGWMGSYSPRRSRSVTRKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBY4</accession>
    <name>A0A398CBY4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000061">
        <property type="protein sequence ID" value="RIE00290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00290">
        <property type="protein sequence ID" value="RIE00290"/>
        <property type="gene ID" value="D3H35_29395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="74"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="163" mass="17128" checksum="D272B44717688094" modified="2018-12-05" version="1">MSLSWPEVDGAAYYKVMQDDRVVGIVTGASFAAEGLKPGTEHRYRIAAGSSGYAWSGWSAEATATTLAARETTAPGRTTANAAGVLGGAQVSWVYPSDPDVVGAKVFWRKTFGAAQFGPTRESVLYPKSVASALVPNLENGQFYEFAVAIVDGDGNRSVSEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CC60</accession>
    <name>A0A398CC60_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_26490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00746">
        <property type="protein sequence ID" value="RIE00746"/>
        <property type="gene ID" value="D3H35_26490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024563">
        <property type="entry name" value="YqhR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11085">
        <property type="entry name" value="YqhR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="200" mass="21782" checksum="28D7139F3B1ED627" modified="2018-12-05" version="1">MPQGRKGNANGRASSTQGGHAQLSKNTASEGEKAIEHFTNPILFSLKVGLFAGIVWGVVRWLETGMNFTQVHQAFLVDPFVKRSMLGSFGWQAIGFAAFIVMSMIAAMFYLIVLGKLRGPWPGIAFGVVWWALLFLGAGPLVGAVPPLKTISWTSYITDFCLFLLWGLFIGYSIAFEFHDEMHRERGGGGSSGSRKPAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCP6</accession>
    <name>A0A398CCP6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_28230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000055">
        <property type="protein sequence ID" value="RIE00473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00473">
        <property type="protein sequence ID" value="RIE00473"/>
        <property type="gene ID" value="D3H35_28230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="44" mass="5227" checksum="1BB4D98C71DFC58B" modified="2018-12-05" version="1">MVEHRSLVNLCEWHRNEFKITASDRSTQYAPSVFDASVWELFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD49</accession>
    <name>A0A398CD49_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF309 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00633">
        <property type="protein sequence ID" value="RIE00633"/>
        <property type="gene ID" value="D3H35_27090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005500">
        <property type="entry name" value="DUF309"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023203">
        <property type="entry name" value="TTHA0068_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34796">
        <property type="entry name" value="PTHR34796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03745">
        <property type="entry name" value="DUF309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140663">
        <property type="entry name" value="SSF140663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="151" mass="16873" checksum="943C4B0DCC2AA15C" modified="2018-12-05" version="1">MAGVGRNANGLAGIRSDSRFLAFIGHFNGDRDYFECHEVMEELWLEEGRHRLLQGLLQAAVGLHHWDNGNLSGAAKLMIGSLGKLEFYETEVLGLDLGALRRELAQSLEELSRSPYDAPFRAFELVLTEEGLALAVERWLKENRSSDKGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD91</accession>
    <name>A0A398CD91_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_28615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00385">
        <property type="protein sequence ID" value="RIE00385"/>
        <property type="gene ID" value="D3H35_28615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06229">
        <property type="entry name" value="M14_Endopeptidase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034274">
        <property type="entry name" value="ENP1_M14_CPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017367110" evidence="2">
        <location>
            <begin position="35"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M14" evidence="3">
        <location>
            <begin position="51"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="482" mass="53621" checksum="53F01D82FDAD8ACB" modified="2018-12-05" version="1">MFSLIRSADRRTRLHAVILVLCFLATTLLPTSFAASAAESPINIVEPKQTYTYEIMTRDIKALAKQYPELIRYRSAGKSEYNRDLWVMEVGRGEATVLLNGSHHAREWISTILLMEMTENIALSDKNDSKWGNYRIRDLLDHVTFQIVPMVNPDGVTLQQKGLDAFPKKDHAALLKMNGGSRNFKRWKANAKGVDLNRQYPANWEQINNPAPGPHYMNYKGKKPLEAKEAQAMFKLANDTKPTVAVSYHSSGEILYWNYKTPAANVKRDLELATDFSAMTGYKLVKPVAKPSGGGFNDWFIQHFAQPGLTPELSPSVGETSVPLANWDSIWKKNKNAVWLVGTTAVKLSMDKKRATETAGWIELKKEATAYQWPMLNSATFGLLAPDYYEVTRTKGDWIEIKTEAGLRWISDRNNRKLSADEIAALLKEREEPEAAEEPGGSVEPSPTTSPEPSASSESGATPASSASPETKENAEPSAITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDG8</accession>
    <name>A0A398CDG8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01226">
        <property type="protein sequence ID" value="RIE01226"/>
        <property type="gene ID" value="D3H35_22800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="112" mass="13398" checksum="9DD7D4EF696F721E" modified="2018-12-05" version="1">MSCRNNFECYRGKWKGIILYHLIDGPKRFNQFRRLYPGMTQFMLTLQLRELERNGIIHREVYKQVPPKVEYSLTEFGTTLKPIILAMKNWGRAHKVRLDDIRLQAANQEKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDR3</accession>
    <name>A0A398CDR3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_26125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000047">
        <property type="protein sequence ID" value="RIE00853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00853">
        <property type="protein sequence ID" value="RIE00853"/>
        <property type="gene ID" value="D3H35_26125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="97" mass="10869" checksum="7CF4A24F15D51AD4" modified="2018-12-05" version="1">MDLGEKLKAKGKDLFAYGGKDETAIGNVLHWTFGDYAVKDPAFKEAYLSNTVDWSKPEYRSMLKEGLERFKQLNAYVRTGSFTNDGSFAQQAFAEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEQ4</accession>
    <name>A0A398CEQ4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_28360</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00342">
        <property type="protein sequence ID" value="RIE00342"/>
        <property type="gene ID" value="D3H35_28360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="3 7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="25"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="336"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="9">
        <location>
            <begin position="595"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="369"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE00342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="719" mass="79773" checksum="77E52C0AFD5440A0" modified="2018-12-05" version="1">MIPVIRFIFACMKPYKKLAMFFFSMQLLDFAFVSLAPLSFKVIIDRAIEPKDMDAFVLILSVLGISGLICLSAGVVSDFVFAKLNALAQKDLRTKLFVHMQQTNIGFFQRTRAGELLSYFSVDAPSIERAMSIILTTGLQSLFVVAVSTIALFYLQWTMALAILVGASAIFIGPYLLGGKARSVHSSFMDQIGLLTGDLQENIKGQKVIRGFNLQRSMTDKFAGRLQALFAIHYRKNAITAQLERIPMISLLLINLTIIGLGSYLALQGHITIGSLVAFFTMYTSMGNSVFNLTFTIPVFADASVSIDRMKQLLDEPKEANGSLRAELWTDKPPEIRFEGVSFRYSEERDILQQIKLDIPSGATAAFVGSSGSGKSTLVQLLLGFYEPNEGRIDINGKRLQDMDRGSFRDRIGVVFQDNFLFNGTIMDNIRMSKPEASAEEVVAAAKEAEIHDYIAGLPDGYDSPVLDEGSNFSGGQRQRIAIARAILRNPPLLLLDEATSALDPISEASINRTFDKLAKDRTVVTVTHRLSSIQGVDRIFVFDQGRLVDSGTHRDMLEAGGYYKRLWEKQSGLTVSSNGQDAEIDEERLSRLPFFEGVDEAVLREIKTLFHTETFSAGQPVIHAGEHGEKFYLIARGQVEVTRRDSASPEGRVRLAVLEDGDHFGEIALLDNVPRTAGVTALTSCVLLVMQRKGLYYVLSNYPEIDARVRRTLKERTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CER4</accession>
    <name>A0A398CER4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01203">
        <property type="protein sequence ID" value="RIE01203"/>
        <property type="gene ID" value="D3H35_22665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="124" mass="14107" checksum="E5958141FEA69B32" modified="2018-12-05" version="1">MEKGGNELRHVRAFQRLPFLFFLLCAFFVFNMPTMMIGDPVATSNSSALVHDMPNSVKATKRTSPTPAGKLLWISALLASLFRFFSYPLFRMTAPPLAFLPSFFLHNLKRMLMPLKFTTSYIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF79</accession>
    <name>A0A398CF79_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00542">
        <property type="protein sequence ID" value="RIE00542"/>
        <property type="gene ID" value="D3H35_27770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="60" mass="6802" checksum="92F7A34065B55CAC" modified="2018-12-05" version="1">MRQSRKEAKLEWMMREGLFPERREAMAFHEGSRTEFADEWSSGSPAGSRSGKRNSPGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFL6</accession>
    <name>A0A398CFL6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01986">
        <property type="protein sequence ID" value="RIE01986"/>
        <property type="gene ID" value="D3H35_14555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="94" mass="10790" checksum="3101D6A6A860F4FB" modified="2018-12-05" version="1">MTLQSRNASPLYKAEAEWVKNVHSTRQKLAGICAQCLNRTVRVQTIDGHTFEGVVIGHDHTYLHIASRDTRFWGPLRPPQLRRLSCSNFWSLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFT3</accession>
    <name>A0A398CFT3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_26585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00762">
        <property type="protein sequence ID" value="RIE00762"/>
        <property type="gene ID" value="D3H35_26585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="2">
        <location>
            <begin position="24"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF_2" evidence="4">
        <location>
            <begin position="310"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="494"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="561" mass="62628" checksum="F315B2BC4F378F4A" modified="2018-12-05" version="1">MAMIPRKEPIPVSSVKEASFSVKELLGLPLLSDARLIAGDTGTGRVVTRVNVMEVPDIIPWVRPGEFLLTTGYALKEEPQRFRQLVPELAKRGVAALGIKTKRFVEEVPAEVAEEAEKHGLPLIEMAPDTVFSDVVRIVMERVLSQESSQLADLQNRIQSMTRLLLDGSGLYAFLDAMEEMLDNPVAVIREQDKPWLSQSLRSAEPTEVWPLLQSLSFRQIGRGANNGFMVLQNTYRTYVSTIPTRRMKQACLVLVEKNRDISPLDALSVDRLAALAGLELANVEAVREVEGKYLDQFLQDWLTGKIVSDADWKLRADVCGCAIPEGTPLCAVLVGWNQPDSTPDKRREMARRLRSERLRSIDGILAAPIGDDLALVLPLAPGTDFAADAGSSSDSLLGRLLSELRHLLGDRELRLFAGRTTNRSEGLHMSWMQAKRTRQVAEVCGLSGDTVTYDRLGVYSLLYLIPMGEEREQFLRRFAFPLQQADRKGGGRLVETLEMFFRCNGNIKLTSERLYAHYNTIVYRLEKIESILGVTLDDPEDRLQLHLALKLGQITPHSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG44</accession>
    <name>A0A398CG44_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_25415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00912">
        <property type="protein sequence ID" value="RIE00912"/>
        <property type="gene ID" value="D3H35_25415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="84"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="290" mass="32458" checksum="635247F4A82B356E" modified="2018-12-05" version="1">MRGPCRMKRKSFAYGELKLVEKGLLYFVLYGGVILFVFPLFWMLITSLKTLGDIHKLPMTWIPSPIQWGNYKQIFIDAPMGKFLWNSIWYTCVSVVGIMIASSMAAFAFARLRARGSTLLFALALSTMMIPSQVTLIPQYLLFNEIHWTGSYLPLVVPAFTGSAFIIFLLRQFYLGISREMDEAVKIDGGSRFTLYWRILLPLSAPALATAAVLELMSRWNDLFGPLIYLNDSAQYPLSLGLANFTAAYGQTPWNLLMAASIVAVAPLLLIFFFAQKVFIQGIVVSGSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGQ7</accession>
    <name>A0A398CGQ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01660">
        <property type="protein sequence ID" value="RIE01660"/>
        <property type="gene ID" value="D3H35_22285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="143" mass="16321" checksum="7E78FCD0B8F462AD" modified="2018-12-05" version="1">MTIHDYDQMIELWSSIDGLALSEADSRQNIEMYLNRNSRLSYVYEAEGDIVGTILSGHDGRRGYIYHVAVKQEFRKQGIAQRLVDLSMGRLKEEGIDKCHIFVLDDNEAGQQFWSRTGWDKRSGFSVYSKDGAAPQSLEGPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHE6</accession>
    <name>A0A398CHE6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Veg protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01402">
        <property type="protein sequence ID" value="RIE01402"/>
        <property type="gene ID" value="D3H35_23830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009366">
        <property type="entry name" value="Protein_Veg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40026">
        <property type="entry name" value="PTHR40026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06257">
        <property type="entry name" value="VEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037257">
        <property type="entry name" value="DUF1021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="90" mass="10339" checksum="1270162CA0975CEE" modified="2018-12-05" version="1">MGKNALLEIKRSLEPHVGSKIMLRANGGRRKTIERTGVLEEIYPSVFIVKLDQEQHHFKRVSYSYADILTESVEVMVCNDEGEVRIQLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHX0</accession>
    <name>A0A398CHX0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome bo(3) ubiquinol oxidase subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cytochrome o ubiquinol oxidase subunit 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Oxidase bo(3) subunit 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquinol oxidase polypeptide III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquinol oxidase subunit 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">cyoC</name>
        <name evidence="20" type="ORF">D3H35_14270</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooctamer of two A chains, two B chains, two C chains and two D chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01935">
        <property type="protein sequence ID" value="RIE01935"/>
        <property type="gene ID" value="D3H35_14270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009486">
        <property type="term" value="F:cytochrome bo3 ubiquinol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02863">
        <property type="entry name" value="Ubiquinol_oxidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014206">
        <property type="entry name" value="Cyt_c_ubiqinol_oxidase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033946">
        <property type="entry name" value="Ubiquinol_oxase_su3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="PTHR11403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02842">
        <property type="entry name" value="CyoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="19">
        <location>
            <begin position="31"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RIE01935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="208" mass="22813" checksum="B2B17A85086B36D1" modified="2018-12-05" version="1">MAAHKHSPAAAAAGHHGHDEGHHDQEALRMMGFWIFLITDVIIFGTLFATYIVLYQNTAGGPSGADLFEMPGVIAETFILLTSSFTSGLAVLCMNRGYKKGLIGWLAVTAILGATFIGLEVSEFVKMVHEGATISTSAFLSAFYTLVGTHGLHVSIGLVWMIAIMFQLSRHGINSVTRRKVNIVSLYWHFLDVVWIFVFTIVYMMGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHY0</accession>
    <name>A0A398CHY0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF5668 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_14900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02050">
        <property type="protein sequence ID" value="RIE02050"/>
        <property type="gene ID" value="D3H35_14900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043726">
        <property type="entry name" value="DUF5668"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18917">
        <property type="entry name" value="DUF5668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5668" evidence="3">
        <location>
            <begin position="34"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="89" mass="9244" checksum="834A54BF269001ED" modified="2018-12-05" version="1">MKQNAEGGTLATAGGSLSGAANGAERQWRVGTWSMGIALLAAGCSLLAQSLGADKDAWLSLSLWWPVLFIVLGGEILVFLALQKQQAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHZ1</accession>
    <name>A0A398CHZ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02876">
        <property type="protein sequence ID" value="RIE02876"/>
        <property type="gene ID" value="D3H35_19845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="165" mass="18576" checksum="3140F92472609A2C" modified="2018-12-05" version="1">MRVPSFEKFQRFTGAAAIFVCGCIVGAAAFNGLANGQLDKAIQRNYELRDQLNDLDSKLRQANQFKSKQTVIKTIRPFIESPQGKTDLDIVTETELKNRLKNDLSIFLGRSIYTIDSDALLARKLLARKIYVDIGGKDYAVSVKTILVVEQELQVWAEAEVHLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI27</accession>
    <name>A0A398CI27_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpG</name>
        <name evidence="10" type="ORF">D3H35_14605</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01995">
        <property type="protein sequence ID" value="RIE01995"/>
        <property type="gene ID" value="D3H35_14605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE01995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="289" mass="31467" checksum="40DDF7F8A44AA266" modified="2018-12-05" version="1">MAKGMREIKRQIKSKQSMKQITKAMELVAASKLRRAQNAALAGRPYADKLKEVVSSIASGSGGTKHPMLQSREVKRTGYLVITSDGGLAGGLNSNLLRKLVNEIRENHKSKDEYAIFVIGRKGRDFLARRDYPIVEQITGLSDAPTFTDIKPIAAAAVRGFENGTYDKLYIVYNKFVNAISQIPTIKQLLPLDESALGGGAKGATADYEYEPSAEEVLSVLLPKYAETLVYSAMLENKASEFGSRMTAMGNATKNATKMINQLTLTYNRARQAAITQEIAEIVGGANAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIM6</accession>
    <name>A0A398CIM6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02235">
        <property type="protein sequence ID" value="RIE02235"/>
        <property type="gene ID" value="D3H35_15990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017297996" evidence="1">
        <location>
            <begin position="31"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="152" mass="16102" checksum="889142D2C30CB8A1" modified="2018-12-05" version="1">MSKISFFNKKSIALLMALALVLSFALPASAAPYSAQFLDSSGSPSAHASSYIDGGVVDITGSAGNYTVTLKLKNFEPSFPLIPISYPSLYVDLNGAPTGDGTYEVAASKTVSGSYTYFTFSGVANLTDNLPVLLHVNVAGIHNQQYNLFLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ20</accession>
    <name>A0A398CJ20_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Ornithine acetyltransferase</fullName>
                <shortName evidence="7">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="7">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">N-acetylglutamate synthase</fullName>
                <shortName evidence="7">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">argJ</name>
        <name evidence="8" type="ORF">D3H35_15190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="7"/>
    <dbReference type="EC" id="2.3.1.1" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02102">
        <property type="protein sequence ID" value="RIE02102"/>
        <property type="gene ID" value="D3H35_15190"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023345695" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023345694" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="7">
        <location>
            <begin position="194"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="7">
        <location>
            <begin position="193"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="407" mass="42480" checksum="2D2D6D75B357FA43" modified="2018-12-05" version="1">MGNYEVVPEGGITLPRGFKAGGLHCGLKKTERHDLGVILCDVPAASAGVYTTNLFQAAPLLVTREALGEGGVLRAVIVNSGNANACTGEQGEADARTMQAKLAEALGVPADQVAVASTGVIGELLKMDRVVSGIEKLPGRLRDDAQGSEDFCQAILTTDLVKKTSCVKLTVDGQEVTISGASKGSGMIHPNMATMLGFVTTDAKIGAPLLQELLREVTDVTFNMITVDGDTSTNDMLVAMASGLAENEELTRSHPSFAAFADGLRHVCEDLAKAIARDGEGATKLIETRVVGASSDDAARAIAKTVIGSSLVKSAAFGADANWGRIIAAVGRAGVEVNVGTVDIRLGDISVLEQSRPVAFDEAVALEYLKGDTVMIHVDLNMGSGQAIAWGCDLTYDYVRINAAYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ34</accession>
    <name>A0A398CJ34_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_26985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00828">
        <property type="protein sequence ID" value="RIE00828"/>
        <property type="gene ID" value="D3H35_26985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="15"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="114"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="229" mass="25614" checksum="758C22314432EA2D" modified="2018-12-05" version="1">MYSVFVRCRSKGYTSVPIGVPASNVQIYILNSYMQEVPIGVAGEMYISGDGVSRGYLNQPELTVEKFVANPFAPGERMYRTGDLARWLPDGNIEYLGRIDEQVKVRGHRIELGEVESALRSHESVKEATVIARKDEEGSAYLCAYFVANGNLGTAELRKRLSEMLPQYMIPSFFVQVEQMPLTPNGKLDRKALPSPEGNYDFGVANEAPRNELDKKWFPYGDKCSAANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ97</accession>
    <name>A0A398CJ97_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diacylglycerol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_16910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the diacylglycerol/lipid kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02390">
        <property type="protein sequence ID" value="RIE02390"/>
        <property type="gene ID" value="D3H35_16910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005218">
        <property type="entry name" value="Diacylglycerol/lipid_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00147">
        <property type="entry name" value="TIGR00147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="3">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="316" mass="34576" checksum="05ECF2A9C1641AF6" modified="2018-12-05" version="1">MNIIRARLIYNPTSGREEVRRRLPAILQRLERGGIETSCHATEGEGDAIRAASDAVERGFDMVISAGGDGTLNEVVSGLAGHEKRPALAILPLGTTNDFARAHGIPKRWSDACDLITKRYTRPVDVGLAGDKYFINIAGGGSLTELTYEVPSKLKTMVGQLAYYMKGLEKITRLQAIPMRITAEGVGEFDEEFMLFLIANSNSVAGFDRLAPDASTNDGVFDVLALRKCNLAEFIRIATMVMRGERVMHDPHFIYFQSSSIRVEADNRVQLNLDGEFGGTLPCTFSILPSHIDVIMDEHGESTYRGGNGSGRGLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJA3</accession>
    <name>A0A398CJA3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NfeD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_25385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00908">
        <property type="protein sequence ID" value="RIE00908"/>
        <property type="gene ID" value="D3H35_25385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="54"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="142" mass="15280" checksum="C916FD0D1A54730F" modified="2018-12-05" version="1">MDGWVIWFIAAGVLLVIEMFTLTFYLLWLGIGALVAAVVGLLFPDSLVIQIIAGAVASLLLTIYTKPLTRKFRSGRGYRDAIDELVGKEGIIVDPVVIGRTGIVKVGNETWSATADEPLQAGETVTVIHRGTTVLEVRKKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJK0</accession>
    <name>A0A398CJK0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03496">
        <property type="protein sequence ID" value="RIE03496"/>
        <property type="gene ID" value="D3H35_12675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="414" mass="48157" checksum="544371F95D948963" modified="2018-12-05" version="1">MSGLFKSLREPGIDLSRFVLSVDLIDPWFELRKIQVISRADYQEDDIASIHVTLEYGNQVKSVLLDSSASTFNLEWNSILDNGEVRRQAVYRYKVLFRHVDGTERPLSLQSPDIIERGDVVEILPRELYSIVPVPIQALNFPWERYSHVEVRTQYEDPEHRISQADSFVLSKETVTEASWKMFVMDSGKTRFRYKIIYRAVDFRDVELPWMETDEERLTIRDPFPTKRTLEIVPLFDWTKVDRAFVDVSYEDPNNGVLEEQSFEFNDKSVATGRFVVALQDANRRQVGFKATIIRKDGTLSEVPQSYTLERRLTVREDMNGHKVVAIRPGDGDFAELKLREIIVKLRYDDPERGLSFADEFAFKSAADRASFEYDYTAEGLRLPNPDRSPLYERLEQYDRLKTSDEPDVVVPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJQ2</accession>
    <name>A0A398CJQ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01068">
        <property type="protein sequence ID" value="RIE01068"/>
        <property type="gene ID" value="D3H35_21835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014852">
        <property type="entry name" value="YwhD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08741">
        <property type="entry name" value="YwhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="168" mass="18793" checksum="937F120D3A7D4D90" modified="2018-12-05" version="1">MSEESNVQPEKKKLSLNVVSNKEHRGFGAGTIDLSQVSCVIIDGGEAYIDVGAMHAKSKIEKGIKFSPNKEDVPNGRPAWVVWVAVDRNEEGSYYAGATSCEMLIDTEARRGWKLLPDHVNRLDAALKRKFMLDNIGDAEKAALRKLLVEHNSEWWDRSSQQLKELLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK30</accession>
    <name>A0A398CK30_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03666">
        <property type="protein sequence ID" value="RIE03666"/>
        <property type="gene ID" value="D3H35_10225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="141" mass="16146" checksum="2FF6AF5DAB6BF402" modified="2018-12-05" version="1">MSFCCGASMIGTKGTLKHYRTRIHNVPILFCPVCHRVEVHYLVENEYEILAEYAHGDGASEVDFHDYVDESDKSLNENSVNNENEDPLAVVQSQIDMALDLLTFARELGDSEWEQQLKRRLGVLSQRRFKLRQKRTSGGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK39</accession>
    <name>A0A398CK39_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0297 protein D3H35_21050</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_21050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0297 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03073">
        <property type="protein sequence ID" value="RIE03073"/>
        <property type="gene ID" value="D3H35_21050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01507">
        <property type="entry name" value="UPF0297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009309">
        <property type="entry name" value="IreB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40067">
        <property type="entry name" value="PTHR40067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06135">
        <property type="entry name" value="IreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037258">
        <property type="entry name" value="DUF965_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="91" mass="10644" checksum="65D465015117605E" modified="2018-12-05" version="1">MSSSDKNQLDKTVMFDVVADPHEMSSREILLTVYDALVEKEYHPINQIVGYLLSGDPAYIPRHNNARSLIRKKERDELIEELVRFYLGQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKA7</accession>
    <name>A0A398CKA7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_10015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000031">
        <property type="protein sequence ID" value="RIE03736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03736">
        <property type="protein sequence ID" value="RIE03736"/>
        <property type="gene ID" value="D3H35_10015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="182" mass="20446" checksum="32F9AA76DB1DADE1" modified="2018-12-05" version="1">MLLKRGKIVIVIDGSRFASYCPSVFSDFMHAMDDEYEMFWMSRALLLLRYLSLFLTLTLPAAYISIVSYNPEIFRVQLTLSIAGSRLVVPYPSFIEVFIMLFMIEALTEASLRLPRYIGSTAATVGGLILGQAVQQAGLVSSIMIIVTSSLRFPISSFRTPRSATPFDLRNTSSSQRRFFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKD5</accession>
    <name>A0A398CKD5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_09435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03766">
        <property type="protein sequence ID" value="RIE03766"/>
        <property type="gene ID" value="D3H35_09435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="320"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="539" mass="60715" checksum="027313FEC3B6E952" modified="2018-12-05" version="1">MITVNGIGLRFGKRPLFEDVNIKFTPGNCYGLIGANGAGKSTLLKILSGEIEPSSGEVHITPGERLAVLKQNHFEYDEFSVLETVIMGHDRLYKVMKEKDLIYTKEDFSDEDGMRAGELEAEFAEMNGWEAESEAAGMLNGLGITSELHDKKMGELDGNQKVRVLLAQALFGSPNNLLLDEPTNHLDLESINWLEDFLSRYEGTVIVVSHDRHFLNQVCTHIADIDFGKVQLYVGNYDFWYESSQLAQQLMRDQNKKKEDKIKELQAFIQRFSANKSKAKQATSRQKMLDKISLDDIRPSNRKYPFIHFKGEREVGKQVVSVENVSLTVDGEKLLENISFVVNKGDKIALVGPYGLSKTALFQVMVGEKEPDAGSVTWGVTTTQAYFPKDNAPYFEGVELNLVEWLRQYSKDQDESFIRGFLGRMLFSGDEALKKASVISGGEKVRCMLSKMMLSGGNVLLLDEPTNHLDLESITALNNGLIDFDGPIIFTSHDHQFMQTIANRIIEVTPNGIIDRMMTFDEYLEHPEVKELRAKLVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLQ2</accession>
    <name>A0A398CLQ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DivIVA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_06590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04276">
        <property type="protein sequence ID" value="RIE04276"/>
        <property type="gene ID" value="D3H35_06590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35794">
        <property type="entry name" value="PTHR35794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05103">
        <property type="entry name" value="DivIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="29"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="161" mass="18750" checksum="48D99EE362DF3441" modified="2018-12-05" version="1">MPLSPLDIHNKEFGRRLRGYDEDEVNEFLDQIIKDYEAMIRENKDLQNQLLVIQEKLGHFTNIEETLSKTIIVAQEAADELKNNAKKEAQLIVKEAEKNADRIINESLSKSRKVALEVEELKKQAAIYRARFRALVETQLDLLNTDSWETLETREPRELEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM29</accession>
    <name>A0A398CM29_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03310">
        <property type="protein sequence ID" value="RIE03310"/>
        <property type="gene ID" value="D3H35_11520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="109" mass="11974" checksum="4B136CAF0A5ADA1D" modified="2018-12-05" version="1">MSYKSIDLQTSLPRAAEMTPLAQHQHQRGASEQAMLGQQAIKNAERQAQRKTKTESAAKSDIKDRDARGQDGGTERRNGRHPEGDAKAPEDSIADAPHPFKGRHIDFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CME4</accession>
    <name>A0A398CME4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 2-epimerase (Non-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.1.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_14565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-N-acetylglucosamine 2-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.14" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01988">
        <property type="protein sequence ID" value="RIE01988"/>
        <property type="gene ID" value="D3H35_14565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="2">
        <location>
            <begin position="32"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="380" mass="42782" checksum="683C9CD13A798BEE" modified="2018-12-05" version="1">MSKLKVMTVFGVRPEAIKMAPLILELQKYPDQIESIVCVTAQHRQMLDQVLEVFGIKPDYDLDVMQERQTLNDISIRVLQGLEPVFREAKPDLVLVHGDTLTTFLASYAAFMQQIKVGHVEAGLRTWNKLAPYPEEMNRQLTGVLADLHFAPTDLSAGNLLKENKPSDLVYITGNTVTDVFQYTVKQDFTHPMLDWAKGKRLILMTAHRREAQGEPHRRIFNAVKRIADEFEDVAIVYPVHPSPAVREPAQAILGDHPRIKLIDPLDVVELHNFYPHTHLILTDSGGLQEEAPSYGVPVLVLRETTERPEGIEAGTLELVGTEEENVYERTKSLLTDAALYSRMSQAANPYGDGQASVRIAQAILHHFGRGERPEPFRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMH9</accession>
    <name>A0A398CMH9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Wzz domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_09680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03813">
        <property type="protein sequence ID" value="RIE03813"/>
        <property type="gene ID" value="D3H35_09680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="8">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="224"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="254" mass="27883" checksum="FC0758481AE7BCEF" modified="2018-12-05" version="1">MELKESFRVLRKRMWLISITVIMTCALVGIYSQFFVSPTYQASSKLLINHEARADGTAVLDLNSVNTNIRLMNSYKEIIQSEAILNKVASEHPEFGLTGKMLMGYISAASASDSQIMTVTARHGEYAQAAAMANAVAEAFKEEIPAIMNVNNVTILTVADPKATAYQVSPNTKLNVLMAFLLSSILVIGLSFLLEYLDDTIKSEADIEKILGLPTLSQVHSIRKDDLSPKSAEPMKPSQQKQTAGDPNYVTIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMJ0</accession>
    <name>A0A398CMJ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03502">
        <property type="protein sequence ID" value="RIE03502"/>
        <property type="gene ID" value="D3H35_12705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="258" mass="28395" checksum="F1B7B32F97D3C16E" modified="2018-12-05" version="1">MRAAPHPPSRPQAVTASTELSSRSGAAFVRLKLSPLEPLAYTCSTFIVTEDSRGIRQWDGLELARTEERLRLKPDDFPIRFVPIAVSPELLELATIRGRCEWLEANHSSASSAFVLDRDRPELAIAIPAAASNASFDFDVLSVEGDRSLHLGPFSAEPLLLGLHLFPEYGPQQISIELAEAASPSLVAIDLLPENREEMAEAVTVLALTRNQSKKSWSYLASSPFYPGFRYRKHAGADGSPEPWSEIQSPFERLVLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMJ6</accession>
    <name>A0A398CMJ6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit N</fullName>
            <ecNumber evidence="6">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NADH dehydrogenase I subunit N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NDH-1 subunit N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nuoN</name>
        <name evidence="9" type="ORF">D3H35_14675</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the complex I subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02008">
        <property type="protein sequence ID" value="RIE02008"/>
        <property type="gene ID" value="D3H35_14675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01770">
        <property type="entry name" value="NDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0874">Quinone</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="8">
        <location>
            <begin position="138"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="512" mass="54563" checksum="A7163BF144229AB9" modified="2018-12-05" version="1">MQTLTWSDAWYLTPELILSAFTIVLAVVDLFLPKRVSRDVVGWLALAGLAIAALFVVWLMLDFKSAGEAGKEASYSQLGGSYRIDDFGSLLKLIFIGATGFIVLSSLGSVRSEDVPIKGELYYLVLPAVLGAMVMASSADLITLFIGLELLSITSYVLIGARKRSGIASEAAFKYVVQGGVASAFILYGMSFLYGIAGATNISAIGKNLLESSAIADYQALLYVSFFLLIAGFAMKLALAPFHAWASDVYQGAATPVTTFLAVVAKGAALAMVYRLFMNTALFAVGTDGAMRDDLFLALAVLAAAAMIVGTAGALRQRNVKRLLALSGVANAGILITPLAIELSDFHASLFSEFFYYLLAYAFMNIGAFAVLTAVSRNGGNETLSGFAGLYHRAPWTAVAMTVLLCSLAGLPVTGGFVGKLLILFAAVQTQAYWLAAILLATTVVSYAVYFSFIRQMYMRSGSDDSGLRIPAPASITIWICAAATLALGFLPMPILDWIHSEFSLITDFIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMY8</accession>
    <name>A0A398CMY8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MurR/RpiR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_08415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03973">
        <property type="protein sequence ID" value="RIE03973"/>
        <property type="gene ID" value="D3H35_08415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="126"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="284" mass="31643" checksum="1216C93996963CDD" modified="2018-12-05" version="1">MRSISIFSSIHSKYNNLTNTEKKVADYVLENAKNVVYMSITDLSDACEVGESSIFRFCKSLAYKGYQEFKIALAHTITVGNEIPQLTDKVLTTDTIDQVASKVLTTNINALSETFNLIDFQKMDRAVDYLVKAERILFFGVGSSLLTAMEAWNKFMRITNKTECAMDSHLQMMSAALMTNKDIAVIISYSGQTKDSIEVARKAKERGAFVISITRFEKSPLTSHSDLSLLCGANEGPLQGGSLSAKLSQLYLLDVLYVEYFKRTYEQSTMNKESTASSVTVKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN07</accession>
    <name>A0A398CN07_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_08525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03993">
        <property type="protein sequence ID" value="RIE03993"/>
        <property type="gene ID" value="D3H35_08525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="26"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="299" mass="32877" checksum="07E61028C60CB188" modified="2018-12-05" version="1">MDNVKTGKVVAFLLSLVKPYPLEVSLCLFGAVFGTFFDIFQARYLKGIVDHAIAGDSSGFTTSVLTIVLILLSGCAVRYVIKYYSGHLGVQVIRDVRRKLAYRLANLPAAYLEKRHSGDLLSRLNNDVGAVQGFVEWQIANMIYTPLAIAGVSVYLFWLNWKLLLASIILLPASMIAAKRLGKAVSAYAVQLQEGFAKFNATIQDVTGGIATIKAYKLEPVLFDKFKEVTDDIMDKKLKTDWRCLFIAPISMVLGVVPQMSCVLYGGYMTVKGQITPGELLAFTYLLGFLIAHCPASPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN13</accession>
    <name>A0A398CN13_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00971">
        <property type="protein sequence ID" value="RIE00971"/>
        <property type="gene ID" value="D3H35_25770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="127" mass="13552" checksum="E2ADD2EF5A323152" modified="2018-12-05" version="1">MGNEAFYWTGRAESYLDRPDATRLDGICVGRYGGSSASGADKNEDGLLVWSDGEGRWEFAVILDAHGSCESAELVIDALLTERPSIESLLSEPVDTAFSGLESTLLALFRSEAFRSDCAAVKGNAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN35</accession>
    <name>A0A398CN35_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF445 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04023">
        <property type="protein sequence ID" value="RIE04023"/>
        <property type="gene ID" value="D3H35_08705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007383">
        <property type="entry name" value="DUF445"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04286">
        <property type="entry name" value="DUF445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="419" mass="46560" checksum="0FA0A2B0133023BB" modified="2018-12-05" version="1">MAEKHRIYRTADWAVAGSIVGALAAYPFQHSFAGGLAFAGFSAAAIGGLADSFAVTAIFKDPLGWKWPGWMGTRIIPKNRDRLIRELSDMVQTDLLSVAAINGKLQQFNLAGWLLAYFDERDSSAELADFLHRIGADLFGLADSTELADHLEQWILDHADQLNVSEIAADIGQWSLNNGYVDRVAEFIVHEVEKWLSSPSFRAMLTALIGQVLDSYSSGSASRKMFQSVAGLSPEKLGEKAQDWLQKLAVSLRSPEHPYRIKLNEQLAAIIVRLREDDALRRWVEDGKMKLLESARTRIDLAGWLQRRMDEVRAAETKTASSWLRGFISQAVRAGRSNPETEQRLNGVLNRLVMDAVAKNHNVIGSMVRGGLSTFTDEKLTEFVHEKAGKDLQYIRINGTAVGFIIGLLLFAATFWIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN41</accession>
    <name>A0A398CN41_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000057">
        <property type="protein sequence ID" value="RIE00334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00334">
        <property type="protein sequence ID" value="RIE00334"/>
        <property type="gene ID" value="D3H35_29135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="353" mass="39713" checksum="87C7F77B4DCA4F79" modified="2018-12-05" version="1">MGIMRRLYRGFIDLKIQDKIFLCFVVVIIASVLGIGISSYYKSSAIFGKKTSRYNVETVQQISTSVDYTLERIDDLSGILAFDQTIQRVFNTDMGAMSERETIAAVNEIESIMITHYNSQIMRSIEIYGNNGLVVKVPSSFNEQGNGPTPKQFVEMASVYRGKTKWLNDAQEHGLLYAVREINELQTAVKPLGTVIISLKSSMVADLLKNVDFDQSGAVLLMDENGSPVIASEPFGQPQAVEEIRQIAAFSSGSSIQTIGGERYFVSFRTSEYTGWKTVGIISLDKLYEDSRMIREWMIVVTLVILLFAFVLARIFAQTITRPIKRMLIPMKKVQMGDWTFRFQAAARMKSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN60</accession>
    <name>A0A398CN60_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_23530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01347">
        <property type="protein sequence ID" value="RIE01347"/>
        <property type="gene ID" value="D3H35_23530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="222" mass="24434" checksum="7C4B57D0E5D9A7BE" modified="2018-12-05" version="1">MSDLMLIRNRSDKQKPQIILILAALISVLLVLLLYWLLSQPEARRLAGYEQEYDRLERRMSSLAESEEKSKKAVEDTILKEILSHLPLDSDMTDYMQILLAAEKTSGVKINSLNVGEEADVSVIANPDTTSEQSGDGQSSTGNEASVTGMAKSRSISISANGDSLQVYQFLETLLHLQRLTIVDTFVINQADGGKLTIDTNIKVFWAPGYKEALTRKGGADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN73</accession>
    <name>A0A398CN73_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03680">
        <property type="protein sequence ID" value="RIE03680"/>
        <property type="gene ID" value="D3H35_10295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="190" mass="20611" checksum="61AF16C319EFDA83" modified="2018-12-05" version="1">MRYRTFAKSLGGAANSGMRYRTFAESLEGAANSGMRYRRFAESLDGATNSGMRYRTFAKSLGGATNSGMRYRRFAESLDGATNSGMRYRTFAESLEGAENSGTRYRTFAESLDGATNRPTTVGYLTRSYGETAFSPTADGYSARSCDETALAQPQPVNWRAVAASEIKKSPETGSGDHLTFVCLALLQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN81</accession>
    <name>A0A398CN81_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_10350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03690">
        <property type="protein sequence ID" value="RIE03690"/>
        <property type="gene ID" value="D3H35_10350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="306"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="580" mass="66236" checksum="ED2D58A1DBE4F787" modified="2018-12-05" version="1">MGWIGWIRNSSIAKSIMGGFLAFMIPVLLFSFILNSKSIDTAQSEVTKSYQNSVVLLARQMDDRVSAMSKLVNSLFTDTNILYMNYKDETDAAQLLAYANLMDRLKFYANASLLNGEIRVYLRNKGKSFSSLTGYGDINELDKREALDLGADKTGHWRMDGDGLSFVQNPLYSRENKGIVVMARIEQSELMRFLDNLNATEPEGVPFLADINGNWVFSQKGGRIDKASLFRKLNDRNSDADQFVFTDDKRDYRVIYGKSASSGLVVGMYFSERYAMRIVTGHVWLMAAFSAMAALLSLLFTWILFSRLLRPFRDLVEGMRKVGRGDFRTRLERIPEKDFAIVFRHFNKMVSDTERLINEVYVERLNSQSFQLKLLQSRINPHFLNNCLNFVYQASMGENHEGAARMASHLAKYFRDMAKGYRDMITLREECDNVTTLVEIQNMRFNGRIDFRPRFEDDLGKHPVPSLIVQPLVENAILHGLIPGKERLHIRVVARKEPEGITIAVEDDGPGIPPEKLDEIRRQTKSSELDRLSIGLNNIYWRLKLNYGDRADLKLDNVDSGGLRVTLVFGDGTPEEKRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNK7</accession>
    <name>A0A398CNK7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polysacc_synt_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_09715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03820">
        <property type="protein sequence ID" value="RIE03820"/>
        <property type="gene ID" value="D3H35_09715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="334"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="492" mass="53845" checksum="6466C4F4ECFDD1F1" modified="2018-12-05" version="1">MKIHSKMIGPAMLIGAQYSTQIIAPLVSLLVVRYLGSEQFGLYASAMAITALLSVMPDFGLQQAALNMSARKEWTIQAILRKSLTVGLQYSLITFLLTVVWLYAIDYEMTTRLLGLMLGLTFFRISIVTVLTTGLQIQGKYGTIAVWNVAVGASQWISTLAAILAGASLYWLVLGPIVVSLVLACLMLVAVGRKLGLFPGANGGADRSLIPVKQLLNGSWNYGLAASMHQLYYKSDVAILSATRQPVEVGQYTVAFRIIELFFLFPGVVFNQVLYPKYCIWCRENIPKLRLYYGIMNKVMVAAGLLAAMILVLFGKEIVGLLFGESQLEAAGFLLILALAIPLRFWVSSAGAVLTNDGLIKTKLKIQCGIAVLNVGLNVLFIPRFGGEAAAINMIVTHIVLLAAYTYAAHRYLLGFARLRTFDWALPAALTAASLLGLFILYRDNLPVRIAGGGLLVAAVAVAFVFWFRRYERNEIRQLFSRGEKQAARLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNT4</accession>
    <name>A0A398CNT4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosome biogenesis GTPase YqeH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yqeH</name>
        <name evidence="2" type="ORF">D3H35_05880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04155">
        <property type="protein sequence ID" value="RIE04155"/>
        <property type="gene ID" value="D3H35_05880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019988">
        <property type="entry name" value="GTP-bd_ribosome_bgen_YqeH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03597">
        <property type="entry name" value="GTPase_YqeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="1">
        <location>
            <begin position="58"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="371" mass="41187" checksum="A93920F83319AA09" modified="2018-12-05" version="1">MTEKTTIRCAGCGIPLQSEDKNIPGYAPESTLSREEAICQRCFRIKNYNEASSITVDQDEFLKLLGGIASTDSLVVHIVDLFDFEGSIISGLQRFVGNNPVLLVVNKIDLLPRVTNWNRLRNWVQKQARESGLKVIDTVLCSARRNIGFDRVVETIGNLRGSRDVYVVGATNVGKSTLINRLISDYSDLKRELTVSRYPGTTLDAVQIPLDDDRSIIDTPGIVYESRLTEIIPRGDLGSLLPDKPLKPLTYQLNEKQTLFFGGLVRFDFVEGERQSFTVYASGALPVHRTKLEKADALYEEHKGVMLSPPGKDELASMPSWTRHRLRIPKGSSQDIFVSGLGWIKANGTAGAVVDVHAPRGIKVMLRDSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNX9</accession>
    <name>A0A398CNX9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_02850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05086">
        <property type="protein sequence ID" value="RIE05086"/>
        <property type="gene ID" value="D3H35_02850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041063">
        <property type="entry name" value="Glyco_H_20C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038901">
        <property type="entry name" value="HEXDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040">
        <property type="entry name" value="PTHR21040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18088">
        <property type="entry name" value="Glyco_H_20C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20" evidence="5">
        <location>
            <begin position="144"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_H_20C_C" evidence="6">
        <location>
            <begin position="422"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="626" mass="71848" checksum="7A3787555847DE7A" modified="2018-12-05" version="1">MKLHFVGDVQDVKEGFAEIAAEAGIELSPEGRVVEVVRHDDNRIVVEAAGGSLRIAYRKKIHFFRAIGLLVEALRERDAFRIEEEPQFDMNGPMFDVSQGGAVIRVEAIKAFLRKMALMGLDMIMLYAEDSFDVAEQPYFGYMRGRYSQAEIKEMDDYAYKLGIEMIPCIQTLSHLADVLKWNVFADIRDDHETLLVGHDRTYEFVEQMIAAASAPVRTKRIHIGMDEAWRLGLGDYLVRNGLRSKFDIMNDHLKRVMEIVERLGLEPMMWSDMYFRAGSPKGDYYDHESVISDEVIAGMPKNIQYVYWDYYHYDEAFYTEWVRRHKRFGSTPIFAGGIWNWKGFVLNYGATLDSTNAALNVCKREGVREVIATLWGDDGTECDWFSALLGLQLFAEHGYAAELDEDKLRRRFHYCTGAQMDDFMAIKNIDEPPGIKPGNLETYNPSRYMLWQNVMMGMFDANLRGLEMAGHYAGLQQEMALYATRNGEYGFVFEVLERLCGVLALKADVGIRITDAYLAGERAALAQLAQETLPEIRARVVKLRAYHIERWHIVNKPFGWDIIDLRYGGLLASLDTAIDRISGYVEGRVERLEELEEQRLPFQSQQGLVDCYLYKHMPTPSRISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNZ8</accession>
    <name>A0A398CNZ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_17425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02478">
        <property type="protein sequence ID" value="RIE02478"/>
        <property type="gene ID" value="D3H35_17425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="436"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="535" mass="61824" checksum="B3F1A9BA9EC964C6" modified="2018-12-05" version="1">MQMMIVDDEAHWVDNLSMHKPWHTLGIDQVHKAYSGREALQILETHPIDIVISDILMPEMTGIELIEKIRERDKRIKCVILSGHSDFEYAKEALRHKAVDYLLKPPTDNELFGAVKASIDQLKAEWESVSSYERTQFTLRENLPLLRGQLLLNAFRGERLPNEEWSRKLENYRLPFRFGECSLLLVRMEDEFGQYRNNGQQLVEYAIINIAEEIFGEYAEVWGVKEELGYLAFLLQLKGEITDDRKENLLEKLAMQLQSKVKQFLKGPLSIVITERFRFPEQLPDRYRQAAAYFRQIVGDEREFVMRVGDSETIVPQGPLDAIHMPPALMNLLEAGRWDAAEEKLMSVFAELDDKWSESWEHCMEAGFLIASSFTNLAHRNGHTLAKLLGPDMEPLQNGDAFASIGKLRKWSISVLGRLREETSNDAKDARSQYVRTIKEFIDKNLHLDVSLRALADRVNLHPTHLSKIYKLETGEGISDYVSVLRMERACHLLRTTDKKVYEISAEIGYLDPAYFIKVFKRQFGVTPQDYRDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP68</accession>
    <name>A0A398CP68_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KAP NTPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_21215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03099">
        <property type="protein sequence ID" value="RIE03099"/>
        <property type="gene ID" value="D3H35_21215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011646">
        <property type="entry name" value="KAP_P-loop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07693">
        <property type="entry name" value="KAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="KAP NTPase" evidence="3">
        <location>
            <begin position="300"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="565"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="741"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="931" mass="107106" checksum="A36DD6DD674661EC" modified="2018-12-05" version="1">MLIVNPETFDQLKEINEAIKQLNGNSLSKESRLELITRIVSKYATEHKETTNDLALFASEFNERFQLRGSIYRISAFRRFPAQKDQILNDKLASGVVHRFNKSFSMRFAWTFNKNGVEVSFGLQSSFSSIKRHSDDSGVFYRAVSKSFSEYNSDLRNLLGQGFNLRINGKKSFLSLEKYIDFLKFNEPHHSEFYLNIPVQEILSNPEMLQAQVNSCFLTIHPLWQAITTSNSLNSYSENTEENFQSMSMGTFSLNNSFLNSSSDELLGSNDDKAESTPLTHCHSDQEFQNDLLDIGEDVESLANLISLREVDNMAIGLFGAWGSGKSFFMKQIKSSVEKNKGRPNDLFHQDIVQIEFNTWHYMDSNLYASLASHIFQKIYDHYKEPESRENMINSLPLITDLRKELNVLQSKKEKFEKELTSEKIGRSVFTAIHNDSEKLLNEVEKLAPNNKTTDKIKAIMAYKNDGKDTLAYLLKVYSKWKLIVKLIPPLAWIFFLLSTGLGIAFFFALHYFFKPNGIANCAWLATLIGYATTAKGILNNEKYKSVKNLWNILTDSLSKVAESRQKIESEIEVLDSKIQNINDEIDEINEGKIIQYYLAERIRSDAYKKELGIINVLRNDFEKLSLFMQTKSTEKNIGRIILYIDDLDRCSPQKVIEVLQAVHLILSAKIFMVIVAVDIRWITKCLHQEYKISLDYEKMNDGASAYDYLEKIFQITYQVNNLSVDDNRKFIKGLFEMSLLSDAKDEAAGAKEESDDEEWNEQDEARFLEQLEESESEEEEQAFEEEQASAYNKLTISEQELSSIIEYAGLCGRTPRTIKRFVNNYRLIKTRYYKDFEPHSTLLLLSLTTGYPLLAIAFLEAIKTSASTDATLNSIFEKLLENENPPKGCKKVFDFIRFRPVGKYLVKDTLATATRVRRYSLYLNDDKEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP85</accession>
    <name>A0A398CP85_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminopeptidase P family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_26480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00744">
        <property type="protein sequence ID" value="RIE00744"/>
        <property type="gene ID" value="D3H35_26480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="3">
        <location>
            <begin position="138"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="357" mass="38634" checksum="BE64B1F2992BCE5B" modified="2018-12-05" version="1">MPNNRVSKLRTLIAKSGADALLVTNAVNRRYLTGFTGSSGVVLVSADKAAFLTDFRYREQAAQQVIGFENVEHGADINATVSELLGQWGVRTLLFEDLDVTFAAYSTMKAKLAPAELVPSGGIVEKLRMVKDESEIAIMQEAADLADRTFEHILSFIKPGVTELSIALEMEMFMRSNGATSSSFDTIVASGERSALPHGVASSRVIGQDEFVKLDFGAYYNGYCSDITRTVFVGKPSEKHLEIYGIVKEAQQYALDHLGPGMTGIEGDALTRDIITRYGYGDYFGHGTGHGLGMEIHEAPRLSLTGDIVLTPGMTVTVEPGIYLPGFGGVRIEDDVVITDAGIQILTRSPKELIVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPF8</accession>
    <name>A0A398CPF8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05286">
        <property type="protein sequence ID" value="RIE05286"/>
        <property type="gene ID" value="D3H35_01845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="520" mass="60005" checksum="478914AF617EA999" modified="2018-12-05" version="1">MFVVEGEDEGLTARHEQAVDEVRSMITDAFFTPSLNPIEPEKEDTWDKIEHLAKTSSALAVTGGWGSLVSFSYRQIDYTRIDRKRLNVNFSERTAVKKSIYPQGHLSGLFKSLREPGIDLSRFVLSVDLIDPWFELRKIQVISRADYQEDDIASIHVTLEYGNQVKSVLLDSSASTFNLEWNSILDNGEVRRQAVYRYKVLFRHVDGTERPLSLQSPDIIERGDVVEILPRELYSIVPVPIQALNFPWERYSHVEVRTQYEDPEHRISQADSFVLSKETVTEASWKMFVMDSGKTRFRYKIIYRAVDFRDVELPWMETDEERLTIRDPFPTKRTLEIVPLFDWTKVDRAFVDVSYEDPNNGVLEEQSFEFNDKSVATGRFVVALQDANRRQVGFKATIIRKDGTLSEVPQSYTLERRLTVREDMNGHKVVAIRPGDGDFAELKLREIIVKLRYDDPERGLSFADEFAFKSAADRASFEYDYTAEGPAGYQIQIVRRFTNGLSNMIDWKTSDEPDVVVPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPN1</accession>
    <name>A0A398CPN1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_18690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02688">
        <property type="protein sequence ID" value="RIE02688"/>
        <property type="gene ID" value="D3H35_18690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="659"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="840"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="960" mass="105035" checksum="6B2016980A494FD8" modified="2018-12-05" version="1">MAIMSATLVLSLTFIDYQFKVVLRGSLQNDELAGFMGSFYGFAGLLALAVQVFAAGKLLTRFGVMTAILVFPAALFMGSVAMMFMPVLALAVAVKGSDKVLGDTINSSVNQLVMLPIPAEWRNRAKGFLDGVVRNGAKGIAGISLIALSPLLSIEQFSIVVAILLVGCIVAAVKVKGAYLKTLLSTLKTRGSGDMDDAELDFMDPASIDLLTETLKSTDKQQVIYSLRTLCGMESFDLMPSVAALLRHPAEEVVVETLIQMERRKFPRMEEELLAFLPATAGAIKAQALITLAATADERFLDFLSDNLEDDGREIKAGAIAGLIKYYGIEGMFRAVGTLKELLESRDEEDRMAMAALFGQIGIKLFYKPLIPLLKDGSPLVRKFALQSAARLQVPELASYAVALLRNSDTRPHALEALASYDEALIIPLLEPYFAEAAEAPLHLPKVYERIGTQGALDKLLAHYSASGFEMKGMLLEAMTRMKSGHAQADKAKVTELIVKEAELYERFSEKMARLGENAAYEQVLEAASQLRSTIVRRIFQLLELIYEAGTIQAVYSSWSEGDARQQANAMEVMDQLLQGQVRIELARIMTARGAEPGVHSKGSAQSSEINDSFSWLLEQGDEWLADVIRHTLGTGLPEERAELAERMERVRVLAKYPLFRELTGRGLSAVAASLRTVRVERGDVIFRVNDPGDSLYLLQSGTVGIYRNDEKIDERKQGDSFGQTAILVNRPRTATVIAEENGVLWRLDSADFYDTLFDKTDIAMAMMKMLSRRLRTVLAHHHDPAANEPEEAAEPPEGAELAAAAKENLSETTADAASEAQDAQGLLLRRVLVLQKIGLFAHLSQEDIVQLARIVEEVAYEAGETVVRMDEYGDALFGIIEGNVRVHRGGDTVAILGEGDCFGEMAVIDSGPRSASCTAVVPTVLLQLHREQVFSLCAQNMDVLKCLMRVLSDRLKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPR2</accession>
    <name>A0A398CPR2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage V sporulation protein AB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04533">
        <property type="protein sequence ID" value="RIE04533"/>
        <property type="gene ID" value="D3H35_05410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020144">
        <property type="entry name" value="SpoVAB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13782">
        <property type="entry name" value="SpoVAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="149" mass="16464" checksum="2B6A1E4ABE241C70" modified="2018-12-05" version="1">MKRRRTSLVHEWLSGGLLAVIGIAGGFTVGSAFIALLIMLDLIPRLVQLTRAYRKSVVFESSILLGTLFWSSADLFDWKAALPAFVLLAPAVFHGLFVGMFAAALTEVLNVIPIVSKRLKLQPYLFTLLVAMVLGKVVGSLFDWLWVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPT8</accession>
    <name>A0A398CPT8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00984">
        <property type="protein sequence ID" value="RIE00984"/>
        <property type="gene ID" value="D3H35_25400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="1">
        <location>
            <begin position="5"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="327" mass="34880" checksum="5B7F2B7EFE1B8CE8" modified="2018-12-05" version="1">MTRIVGVDAGGSKTYAVLVDERGNLLGTGLAGRGNHQSAGIHAALSQIKKSIELALQEAALSWDDIDYFQYGLAGADRDKDYDILRPALAALPCRNWGLVCDTMEGLRVGSSDYTGVVLVCGTGTNAAGRNPQGQSVQTGGFGFLYGDGAGGSDMAIATFRAAVRSWELRESPSLLTDLVPRHLGYDTMEQLWNDYLDKDIYSVPAHLTLVLHDAADQGDEAAGSILAQTGRELGLAAISVIRRLGGFEELAKIPIVLVGSILTKGRSPHLLKALSDTLEQENLAYELVIPEAAPVYGAVMIAMDTLGIEIDDGMKQKFIQYGGHDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPV6</accession>
    <name>A0A398CPV6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Linear amide C-N hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01004">
        <property type="protein sequence ID" value="RIE01004"/>
        <property type="gene ID" value="D3H35_21350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="386" mass="44560" checksum="26685CF902A36F24" modified="2018-12-05" version="1">MSLFKSETQLPLDTSGFMTVRHLTLKGTSYEIGSHLASLARSRHHVEPRRQPSETLRNRFQREYVQRRYPIHFERMKGIAAAFDSKLDDDELDFNQLMYNMEPFGCSAVFYPPSKTKSGQGFLSRNFDFSLKTMDDREASENHPAVVGSPYIMELYPDDGYASLAMCNYDLVNGVLDGINERGLVVSILADDESANTYPREPAFTRQVGLNELQIMRLILDSCANVEEAKQALLSHRLYYAHIPLHYLIADRSGKSFVFESSYTNNRYHILDGGTEPFIVSNFLLHRYADGTPLPEDDNPNGMYARYNRIREKIAAHSEPFYTDEEVREYNRCAYIDPSFDKTSRTLWHSVYDTCENSMKVDFYVKDLPEGSQRSESFTFRLKPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ27</accession>
    <name>A0A398CQ27_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YycC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_06855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04320">
        <property type="protein sequence ID" value="RIE04320"/>
        <property type="gene ID" value="D3H35_06855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025550">
        <property type="entry name" value="YycC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14174">
        <property type="entry name" value="YycC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="51" mass="5823" checksum="B1802C77C14B7527" modified="2018-12-05" version="1">MRPLPISAETAQKLAAFMKVPLEHLMHMPQHLLLQKLGEMAKVNENNEKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ35</accession>
    <name>A0A398CQ35_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Glutamate racemase</fullName>
            <ecNumber evidence="2 7">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">murI</name>
        <name evidence="8" type="ORF">D3H35_21990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Provides the (R)-glutamate required for cell wall biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2 7"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01094">
        <property type="protein sequence ID" value="RIE01094"/>
        <property type="gene ID" value="D3H35_21990"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="7"/>
            <end position="8"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="39"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="71"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="258" mass="28566" checksum="5B509C9669CD9BCA" modified="2018-12-05" version="1">MRIGFFDSGIGGLTVLAEARRLLPTHDYLYMADTLHVPYGTKSKEEVRAYILDCVGMMVREGIDALVVACNTATSIAVAELRELYSFPIVGMEPAVKPAVEMNRATGKRVLVFATPLTLQQPKYYALVSRVDEEGIVDSLPLPELVRYCESLQFDETLMGDYFRGKLAPYELDKYGIVVLGCTHYPFYTDILRKVLPPHIQIVNGNVGTVKRLSALLSRYGIADSCGSGNIRFMCSGGDPAYIEKMQTAFALLQSRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQK3</accession>
    <name>A0A398CQK3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_15165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02097">
        <property type="protein sequence ID" value="RIE02097"/>
        <property type="gene ID" value="D3H35_15165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="PTHR10003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="SSF49329"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017277257" evidence="4">
        <location>
            <begin position="28"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Cu" evidence="5">
        <location>
            <begin position="114"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="243" mass="25891" checksum="42E1E78604A066AB" modified="2018-12-05" version="1">MKRKIDFFQVTAAFLCGSVFFSGIALAQTKGSISVSPSKLRFLVQGTDRSSSDGQFANNGVAVPESLQYKGTTYVPIRLAANLIETPVYWDGETRSVWIGEAEVRIVNGAGAVIGEAKLSEQEGGVHVHLTASQLSPGKHGLHLHEKNFENNDFKTAGGHYNPTGKKHGHNNPEGHHAGDFANLEAGADGTAHAEFVIEGMTLEKGKENSVWGRSLLVHATEDDGKTDPSGNSGDRVAGGNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQK4</accession>
    <name>A0A398CQK4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_04915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04813">
        <property type="protein sequence ID" value="RIE04813"/>
        <property type="gene ID" value="D3H35_04915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004761">
        <property type="entry name" value="Spore_GerAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34975">
        <property type="entry name" value="PTHR34975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03845">
        <property type="entry name" value="Spore_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="297" mass="32378" checksum="6AFB62181F7C34E7" modified="2018-12-05" version="1">MKASPFRIVSCLAGKSKAGGERMSMPIGKTSIAPIIMVIMLSIGLLNHVIIMPLLLGAAGRDAWLSILLCSALLPLWLLIVHRVVQAVRQQPMLAWIESVSGKASRMTVAFIFGVLLVMDIVITSTDTLTWATTTYLPKTPMVVTTSVFLILCGFAAYVGFRTIAIVSGILLPFVVLLGFFVAGANTGRKNYNELFPILEHGWSPVLRGMLIVGGGFAELILFILLQQYANSPFKRKQVLLTGVIISVLCMGRRSRRLPNSVRRRPVSNGTRPFLNGVSYRSANISSISIFLRSTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQN5</accession>
    <name>A0A398CQN5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_04910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04812">
        <property type="protein sequence ID" value="RIE04812"/>
        <property type="gene ID" value="D3H35_04910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="3">
        <location>
            <begin position="253"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="344" mass="38405" checksum="2A89F6A78ED95CFE" modified="2018-12-05" version="1">MNDNVIPVYVLSGFLGSGKTTLLNLLLDDAKERGWKPAVLMNEVGDIHIEGAVAREDVPMTELLGGCICCSSRGDLGLELVKLAQEHQPDVIWIESTGIAQPFEIMDSVTEASLYAKIELRGVITVVDARHLLDRLRIGSGKTFKLMKEQIRVASHLVLNKIDLVREEELGEVEAALSDWNAHAKLAATVKSRIEPDWVYADWTNPNTNELAIRSACNNDDPDHEHDDSCASAPYSPHAHHHAHEENEAHDHVNAVTHYLPGAADSHAFEAFLKRLPDGVYRAKGIVRFHDTANRYLFQYAYKETDFLPITPQKTVHDVAVFIGEGFSKTELRKQLDDLFEAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQV7</accession>
    <name>A0A398CQV7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">greA</name>
        <name evidence="11" type="ORF">D3H35_13535</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the GreA/GreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01811">
        <property type="protein sequence ID" value="RIE01811"/>
        <property type="gene ID" value="D3H35_13535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="10">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="9">
        <location>
            <begin position="83"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE01811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="158" mass="17599" checksum="DCDC1620027DD724" modified="2018-12-05" version="1">MSNEEIILTPEGLANLEQELEELKIVKRKEIAERIKIAISYGDLKENSEYHSAKNDQAFMETRIKTIQRMLKVAKVARSADISTVQVGFVVVLNDLEFAEKIEYRIVGPAEADVMENKISYESPLGQSLIGKSVGDKISVNAPMGKVEYELLEIKAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQV8</accession>
    <name>A0A398CQV8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02207">
        <property type="protein sequence ID" value="RIE02207"/>
        <property type="gene ID" value="D3H35_15820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="1">
        <location>
            <begin position="132"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="407" mass="45201" checksum="7F1EB45AB4D35976" modified="2018-12-05" version="1">MTRERCGTRATTRSDEKMIIVRTNQCRPGMKLGRSIYTEQGHVLAGRGFILTEHAINKLAQLGLPFLHIEEEGTEDIAPDQAIRDETIIVLHGALSHVMDELLVGKRDVLSANVVRFCHDAAKMLVADLRERRNHLCLPVHLTTMLADGDKQHFLEHALNVGVCATRLGLEDGLNSENLHALAMGAILHDVGRLLLPGGLKCTAKDSSLEKYMSHTELGYRLLRDSGFPLLTAHSALYHHERIDGSGYPYGLESNSIHKHIQWISMFDLFDTLVNGRGNNSPMLPHEALEVLYGGAGILYDLEKVRRMRDNLALFPKGTTVRLSSGEIGVVSGFHEDSKQRPIVRVIRTPEGNSLRYPYEVDLKQQLHLMISGLGSEKSFAVGAGAAAADWSSETKERRSNRVFHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQW7</accession>
    <name>A0A398CQW7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Crp/Fnr family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_13590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01821">
        <property type="protein sequence ID" value="RIE01821"/>
        <property type="gene ID" value="D3H35_13590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00325">
        <property type="entry name" value="Crp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="179" mass="20098" checksum="D9EB8CA401E341A2" modified="2018-12-05" version="1">MILHKGETLFRQGESGPLYRLKSGLLKIVRLHGDGTPILVNVIVPGETIPHHSLISPNPYYGTAIALVTCEIDVIPAAEWYTELERNPDKCRSIALLLQDKLRMMQQRIDQLTEVAPADKLRKLQAWFHSYIAPTSMTDVLTQDEIGQFIGLRRETVNRLLRSQAANDAYKVPAGPKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR15</accession>
    <name>A0A398CR15_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03709">
        <property type="protein sequence ID" value="RIE03709"/>
        <property type="gene ID" value="D3H35_10460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="268" mass="29885" checksum="DC3CD663CE559A3E" modified="2018-12-05" version="1">MTYRLVAMDLDDTLLNDELKVTDTTRQAMADAIARGVHLTIATGRMYDSARQTASQVGLNVPIITYQGSLIKNLLDGEVLYERSVPPAAAEKLYQYCLAHGLHLQTYIDDKLYTPEENDKLFSYVKQSNIPYTVESDFGKLVSNPKQTKLLIIDEPAKLDAMIPELRELLGPEVHVTKSKPNYLEFMHHEGTKGHALRFLAKHFDIPIEETIAMGDAMNDHEMVEAAGLGVAMANAVPALKEIADYVTLSNNDDGVRHVLEKFILNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR23</accession>
    <name>A0A398CR23_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04972">
        <property type="protein sequence ID" value="RIE04972"/>
        <property type="gene ID" value="D3H35_03275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="29"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="421" mass="50113" checksum="1DBC49DCC0456BB9" modified="2018-12-05" version="1">MNRFIPTIYLWKTHSPYGGNRMMKPDQQQRYYPLTHAQNRIWYIEKLYPKTPLFNLGGTITFKGHTDLKRLEQALIRFISNNDSLRLKFVEVEGQVQQYFSKDDTPEIEYVDFSFAIDPLSRYKEWVAEQVSIGFELIESPLFYIALFRLNPNTCGYFVKFHHLIADGWSMNILTSQVCEMYGRLIDHSEPDSLGEYSFEAYIPAEKELQTKDRFHKDKTFWREKFLELPDAFLVKSSDDIRAERMTFFLDEAKTQLVKQFIKRHNLSMNSFFMTIMLIYLFRTTHNEDLIVGTPVLNRSGKREKNIFGMFVNMMPFRKQIRENEDTIALFDQVNRELIQCFFHQKYPFDLLVKDLELHRKGYDQLFQICVNYSNAKLVDQLEGLRSRTRNFSRVIRSIRFICSSRIGMNPEACDWISNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRA0</accession>
    <name>A0A398CRA0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pantothenate synthetase</fullName>
            <shortName evidence="5">PS</shortName>
            <ecNumber evidence="5">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pantoate--beta-alanine ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pantoate-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panC</name>
        <name evidence="6" type="ORF">D3H35_04120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="5">The reaction proceeds by a bi uni uni bi ping pong mechanism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04680">
        <property type="protein sequence ID" value="RIE04680"/>
        <property type="gene ID" value="D3H35_04120"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PTHR21299:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="151"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="188"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="295" mass="33027" checksum="DFB9F1B770BE463D" modified="2018-12-05" version="1">MTLSIIRHIPELRERIAEFRRSRPDSSVGFVPTMGYLHQGHASLIRRSAEENGLTVVSAFVNPTQFGPNEDFDKYPRDEARDKSLASEAGAHILFMPEVSEMYPDPIRTTVAVTGLTDRLCGASRPGHFEGVATVVTKLFNIVTPDRAYFGLKDAQQVAVIARFTRDLNIPVDIVPCPTVREADGLALSSRNVYLSPEERRQALILSRTLGQVPDWIEEGMTEAELSVRLRGKIRSQPLADIDYADVLTYPELEFPRAGMRLRNSDRPLLIALAVRFGNTRLIDNVLLFPQEVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRG7</accession>
    <name>A0A398CRG7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infA</name>
        <name evidence="5" type="ORF">D3H35_02360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035121186.1">
        <property type="nucleotide sequence ID" value="NZ_QXJM01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05132">
        <property type="protein sequence ID" value="RIE05132"/>
        <property type="gene ID" value="D3H35_02360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="71" mass="8117" checksum="E94D6CD7B7D288FF" modified="2018-12-05" version="1">MAKEDVIEVEGTVIEPLPNAMFKVELENGHQILAHVSGKLRMHFIRILTGDKVVIQLSPYDLTRGRITYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRU8</accession>
    <name>A0A398CRU8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2238 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05292">
        <property type="protein sequence ID" value="RIE05292"/>
        <property type="gene ID" value="D3H35_01800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014509">
        <property type="entry name" value="UCP020606"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09997">
        <property type="entry name" value="DUF2238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020606">
        <property type="entry name" value="UCP020606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="181" mass="20472" checksum="08762B019F24B975" modified="2018-12-05" version="1">MALSPTKRNQWAADSAPLAVIILTLVFTYKRYRFTNLSYFVMFVFFCLHTYAAHYTYEGTPFDHWLKSSFHTKRSYYDRVVHLFFGLLCSIPFLEILKCKAKLRGFWSYFLTVVAVLGFSAAFEILEMLAALAAGKGGEAKFVGMQGDIFDTQKDMALGLLGGAATMGIAAWINRRKKKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRV2</accession>
    <name>A0A398CRV2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Undecaprenyl-phosphate glucose phosphotransferase</fullName>
            <ecNumber evidence="9">2.7.8.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_15125</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.31" evidence="9"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02091">
        <property type="protein sequence ID" value="RIE02091"/>
        <property type="gene ID" value="D3H35_15125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017473">
        <property type="entry name" value="Undecaprenyl-P_gluc_Ptfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03023">
        <property type="entry name" value="WcaJ_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="281"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="468" mass="53725" checksum="FB74B9154768BBD3" modified="2018-12-05" version="1">MIRRSQGFLTQMYALVDFLCIQLVFLFSWWLKFQSGLLPSGTPIPFDNYLLWSVIYGALILGGSYSLNLYAPKRKKSFSFELMKIVQIHAGSLLLLVSILYLLKEVDVSRSYLFLYAVSNVLVAGIYRYLLKYSLRRFREKGYNKQFVLILGAGSLGRRFYMNLQQHGEMGFEAVGFLDDYQDKHEPSFSEYKPILGKVDELAGILDRMTIDEVIIALPLQAHPKFAAIVAACEKAGVRTMIIPDFYDILPSRPYFDNFAGIPLINVRDIPLDELRNRFLKRTFDIGFASAAIIVTLPLLVLIAVGIKATSKGPVVFKQERVGLNRRTFTMYKFRSMRADTASTGDTGWTTENDPRRTRFGTFLRKTSLDELPQFFNVLFGHMSVVGPRPERPYYVEQFKEEVPKYMVKHHIRPGITGWAQANGLRGDTSIENRITHDIFYIENWSLLFDIKIISKTFVQGFMNKNAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRY8</accession>
    <name>A0A398CRY8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="6">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase II</fullName>
            <shortName evidence="6">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">lspA</name>
        <name evidence="8" type="ORF">D3H35_00690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase A8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05342">
        <property type="protein sequence ID" value="RIE05342"/>
        <property type="gene ID" value="D3H35_00690"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE05342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="161" mass="17518" checksum="67C2F8A7868801D2" modified="2018-12-05" version="1">MIFYGIALGVAAIDLLSKLAIEWTMSLGDTLNVWDSVIHFELYKNSGAAGSSFQGYARFFAVLAILFIWFAVRYKRQGKAKDRVLEIGLAVLVGGAAGNGVERLLFGEVTDFLVFGSRSGIMNIADLAINAGVVLLIVGIWRQNRTERRVTLKATGASTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSA6</accession>
    <name>A0A398CSA6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_00435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000005">
        <property type="protein sequence ID" value="RIE05433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05433">
        <property type="protein sequence ID" value="RIE05433"/>
        <property type="gene ID" value="D3H35_00435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="129" mass="13877" checksum="7715C82AC9D47112" modified="2018-12-05" version="1">MIKLCVEFAGFQSVDVLGNPKAAPIALIFVIAWRTVGFAMVLILAGLKSIPKELEEAGEVDGASRWHTFWLIKLPLLKTPIMVTSIILMLSNFNNVDVPMVLTGGGPGDATNVITMELYDQGLCTITSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSD0</accession>
    <name>A0A398CSD0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Permease DsdX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03648">
        <property type="protein sequence ID" value="RIE03648"/>
        <property type="gene ID" value="D3H35_10130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015128">
        <property type="term" value="F:gluconate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003474">
        <property type="entry name" value="Glcn_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30354">
        <property type="entry name" value="PTHR30354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02447">
        <property type="entry name" value="GntP_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002746">
        <property type="entry name" value="Gluconate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00791">
        <property type="entry name" value="gntP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="453" mass="47789" checksum="44BA80471C4F1D3E" modified="2018-12-05" version="1">MSAIFGLSHNATLLIWTLVAIVFLIGFISKLKWNPFVTLLLASILLALLAGMKPSDAVASITKGLGGTLGTIAIVIGLGTMLGKMMAESGGAERIATTLIDKFGDKRVHWAMLAVGFLVGIPVFFEVGVILLIPIVFIVARKTKMPLLQIGIPVLAGLSTVHGLVPPHPAPMIAIDAYNANLGQTILYSFLIGIPVALISGPVFGKWIGRRIQVEPSEQLVEQFAMKEERRLPGFGITLFTILLPVILMLIGSVATIADPEATSGFTRLCEFIGHEIIALLIAVVFSFFSLGYARGFTKEQISRYTSESLAPIAGIVLIIGGGGAFKQVLIDSGVGKAIAEMAVHANVNVILFAWLVAGLIRVATGSATVAMTTSAGIVAPVLALTPGANVELAVLATGAGSLVLSHVNDAGFWMVKEFFNMSVSQTLKTWTVMETLLSVLGLIFILAVSAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSG3</accession>
    <name>A0A398CSG3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000002">
        <property type="protein sequence ID" value="RIE05472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05472">
        <property type="protein sequence ID" value="RIE05472"/>
        <property type="gene ID" value="D3H35_00140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="130" mass="14574" checksum="6B3DF61EBBD29504" modified="2018-12-05" version="1">MFLPMSLLRGGLQAFLLPFALTVTYALLSSLIVALTVIPAKLSRVLKNSKIKEHLPSKRFTSFLEWNLRFKWLPILIAFLLLLGSVGTYFSLPKERSTIPALAVSVLRSTISRIRRSMKCAKTDSSSKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSH6</accession>
    <name>A0A398CSH6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03698">
        <property type="protein sequence ID" value="RIE03698"/>
        <property type="gene ID" value="D3H35_10390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="131" mass="14686" checksum="4CBABEF7AC24E21F" modified="2018-12-05" version="1">MAVRKIEHVGVMVHSLDTSIPFYENVVGLTHLETILHTNGVIRLAFLAFPESRDTEIELIEGYDGQLTAEGQVHHVAFAVDDLDAEYARIQSLDVNGVDDAITTLPNGSRYFFFRGPDGEFLEFFQSTRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSZ5</accession>
    <name>A0A398CSZ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02441">
        <property type="protein sequence ID" value="RIE02441"/>
        <property type="gene ID" value="D3H35_17200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="785" mass="84448" checksum="9CEC0360EAEFBCEF" modified="2018-12-05" version="1">MSTKAEGRFHLNAAALQFLDTVYVRATQREQRRRQIIGEPVHPVRNDSLLADWPMSAVKPRQAAASANGESNAYFHDTNFSQLPKEDYAFDPDAPVASSSDEFRDELAHANSLEMEFEFEQMARSSQDAESLADGLVLPGSAQDAARMRRDAGQAVHADGNARQAVYAESDAVKREPGMADEDGHLLQLARDSAHAERNAVNPALGAAEADELSLRVGRDVARAERIAESPAAEADELSLRVERDVARAERIAESPAAEADELSLRVERDVARAERIARSPERGMAEAEELSLRVERDVARAERIARSPERGMAEVKELSLHVGRDVAYSERIAESPTPVATEADELSLHVGRDVARAKRIPMNSARDAAEADELTRVAVQSASSARDKLLLAIAPSLRRRSAVLRDAQDAADEQRRFFGAGSAPRSVPNGVGQTLRSEPFAETPGSRQKQADAVSGRSTINVQHRTDFGDQPPETLHHTTTAYAEGDSLHPALSDTENTNSSKDPDVASEAAALSKPSTSPLSGTALREGRSAIAGSADEAVGSPTGSSLAESGHTVQDRPLSSLYRELQRFTAAQTGSNVPPPSNDRYHSSGSVGFRAEKVLSDEPSWKPSRAQAPEMTFLSERPAWSHFSEEGAAEPNLSNRDSGVPRTFPVSPSHFEAGTFNDGKSATGQSNYAIPGNFPVAAGSAFRGGTLTTMTGFSDEQGAVTIRRPGGIPAFRSLNGMQESGLSQSFAAQGDFTRGASSDSDFTAFPTVPEPDIDLRETLARMLREDAMRHGIRLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT59</accession>
    <name>A0A398CT59_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02501">
        <property type="protein sequence ID" value="RIE02501"/>
        <property type="gene ID" value="D3H35_17575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="113" mass="12316" checksum="FE7B0564BB079ADE" modified="2018-12-05" version="1">MPVIAGTNPILKDIGSTYTLNVEIANAANRYFAYSVRDFDVVTATPPPNYGDDYWSVAPSPSLYYPNTGGPSNIMVQKNQKYVAIYELTSTAEGSKIIGYTEFVIADLPISPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT98</accession>
    <name>A0A398CT98_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lytic transglycosylase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04479">
        <property type="protein sequence ID" value="RIE04479"/>
        <property type="gene ID" value="D3H35_06300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLT" evidence="1">
        <location>
            <begin position="87"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="220" mass="22852" checksum="00C9AFE0C57B575C" modified="2018-12-05" version="1">MKQMLLSQWLTETSPFAASSTNGTTGESGGMFELLLGQLMETASIGGTTASGSSLPSNANMLASWGTTQFGNYLTSDTGSSSAFDGLISAAAAKYGVDPALIKGIVQTESSFQSNAVSSAGAKGLMQLMDGTARGLGVTDSLDPAQNVEGGTRFLSYLLRKYEGNVTSALAAYNAGPGRVDRLGLTTDALLASRMSELPEETQQYIGKVLEASRQWSASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTL6</accession>
    <name>A0A398CTL6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_19120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03197">
        <property type="protein sequence ID" value="RIE03197"/>
        <property type="gene ID" value="D3H35_19120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="218" mass="23946" checksum="E7BD09C967EF9D38" modified="2018-12-05" version="1">MKKKSILDDVSFTIETGSLAGLLGPNGAGKSTLMRILCGLAEPDKGTANVFGNKPSVDTLSQLSFLPDRGKLPAWLTAGEWLRFAEGLYPDWHKSREAELVEKLGIDRSSRIGTMSRGEEARLQLLTCLTRQVRLIILDEPFTGVDLLSRERIASAVVGELADGNRTFLIATHDIREMESLFDRIVLLGGGTVKGIFDTEALRMEGKSVESCYREVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTN7</accession>
    <name>A0A398CTN7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Efflux RND transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000002">
        <property type="protein sequence ID" value="RIE05470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05470">
        <property type="protein sequence ID" value="RIE05470"/>
        <property type="gene ID" value="D3H35_00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="168" mass="18053" checksum="9D905E84C26873EB" modified="2018-12-05" version="1">MNAGPGSFFGGGSSTQVFVDVTGDNLDQLTKSADEVIAKIKPIKDVLKVESNQEEKKTVYTLKVNASQAKAGDIASQLQGMLNSVPIGTMKANGQPVSVILEPVLKPQSEADLENLTVMTDAGPKPASSVAEWVKEELPTKFFHKDGKSYVRGCNCRAKPTVHCRRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTQ4</accession>
    <name>A0A398CTQ4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_18715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02691">
        <property type="protein sequence ID" value="RIE02691"/>
        <property type="gene ID" value="D3H35_18715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="11"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="502" mass="53254" checksum="B3B846DA8B9B2203" modified="2018-12-05" version="1">MTAKTNNRALVLTGLLIGLIFAELDETVVSTAMPTIIRELHGLSLYGWVAGVYMLAVTMFMPIIGKLADLYGRKKVYLSCMALFITGSIVCGLSSSMTMLLAGRGIQGIGAGGLMPLALVIIGDTYPLEQRAKIQSLFGPMMILPQLLGPTVGGSIVGHMNWHWVFLINIPVGLLAAAVLSMGMRESRGEEKRSIDWAGAVTLVLALLSLLLAPVLIDNQGLAWSSPLIIGLLVLSAALIALLVKIESKAKEPIIPLHLFRNRNVVVLSLLVLILMLGLMGGIATFPFFAQNVMGLTPTAAGYLMLAFMAGAIPSSIVNGFLITKVPYRNLFIVCFALPIAGFILLSQIGLGTTVLYIVITFFILGLGLGALFGGDNLIVQESVEKQHSGVALSTVQLFQSLGATIGLSVFGSLLARHIKTGVSDLADQLPAGTADNIATGGIPAGIAPDLLTKVQTVFAEAFQNIFVISLGFVIAAFFIVWFLKKEVLTPKEKTAEAVSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUE9</accession>
    <name>A0A398CUE9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02901">
        <property type="protein sequence ID" value="RIE02901"/>
        <property type="gene ID" value="D3H35_20000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="320" mass="35617" checksum="0A3420BF7E8585F2" modified="2018-12-05" version="1">MKLGVFIVLFGQQSFEEALDSAKNAGCLAVEIGTGAFPGTSHVNAQAIVNDDAAIERIREAVQSRGLTISALSCHGNPLHPDQAIAKSHHDDFVATVQLAEKLGVDTVITFSGCPGESVNSKYPSWVTCPWPPDFLTVLEWQWNEIAIPYWKEQSAFLRKHGVKVAIEAHPGFLVYNTETAVRLRREAGDNIGVNFDPSHLFWQGMDPIECVKVLGDSIYHVHAKDTKFDKRNTAINGVLDNKNYGEILERSWVFRTVGYGHDDEFWKDLISTLRLVGYDGTISIEHEDGLMSVNEGFTKAANFLNGLILREKVGEMWWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUW3</accession>
    <name>A0A398CUW3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03657">
        <property type="protein sequence ID" value="RIE03657"/>
        <property type="gene ID" value="D3H35_10175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="5"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="317" mass="33657" checksum="5D48D6F822659C85" modified="2018-12-05" version="1">MANTIPNRQAMCEKLLELAGEDRNIMVLTSDSRGSAAMGPFANKFPEQFVETGIAEQNIVGIAAGLAHSGKIPFVTSPACFLSMRSIEQIKVDVAYSGTNVKLVGISGGVSYGALGMSHHSLQDFAVTRAIPGLAVVVPADRHETKKLTEALVQYEGGAYVRIGRNPVEDVYESEDYEFVIGQAVRMKEGGDLTIIAAGETVRVALDAAKLLEERGIRARVLNMHTIKPLDVQAIVAAAVETGLIVTLEEHSVHGGLGAAVAEVTSQHCPVPVHILGIPDEPAIAGKTSEIFAHYGITSENVRDIAVKRLEAKAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVD1</accession>
    <name>A0A398CVD1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03867">
        <property type="protein sequence ID" value="RIE03867"/>
        <property type="gene ID" value="D3H35_09975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901575">
        <property type="term" value="P:organic substance catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="146" mass="16727" checksum="BE1E7DEEEB95FFB7" modified="2018-12-05" version="1">MIGEQDIYLAAGIGGAIKTPPERYEPFSFRTFRYVRLEVNAGAEPLALRSSISGRRVIRLKRSPICQLDSTLTPLWNISIRTLKRCMHETYEDCPYYEQLQYILDTRLQALFTYPLSADDRLARKAIFDFHSSVLRTACFKAVSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWV9</accession>
    <name>A0A398CWV9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IS1182 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_02705</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence IS5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05058">
        <property type="protein sequence ID" value="RIE05058"/>
        <property type="gene ID" value="D3H35_02705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DUF772" evidence="7">
        <location>
            <begin position="55"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="6">
        <location>
            <begin position="218"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE05058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="392" mass="45304" checksum="9CE7A43DD07D9EDE" modified="2018-12-05" version="1">MSFIESENRYQIQLLPNTLDDFVDEENPVRVIDAYVDSLTLEKLGFQVYSGSKAGQKPYRRQELLKLYLYCYMNGIRSSRKMETETKRNMELMWLIGKLQPDHGTLSAFMKSNQTAIKKLFKEFTLMLKGFGLIDGQLVAIDGTKLKANCSKKKHFNDSIISKKLEQIDEKIDAYLRDFLTEDNRLKKQEITEKLAVYQERMHELQVMKHELKEIGESQLCVTDPDAKSMKNNGKHEVCFNVQTAVDSKFKLIVDCDTVNDVNDQGQLSNMGHKAKQVFHDQKTTIVADTGYYNYLEIIDVVDENTELLIKPQKGKQDKVASGFDKANFKYDSINDRYICPLGYELPFKWNGKQDGKEYKRYTCEAFDFCGQKGLSSTCLFSDLAVIQQTRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXS2</accession>
    <name>A0A398CXS2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05338">
        <property type="protein sequence ID" value="RIE05338"/>
        <property type="gene ID" value="D3H35_00670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="117" mass="13873" checksum="6B178C124D909150" modified="2018-12-05" version="1">MESPYEQWRLVKLGSYVEHVDFFSIYQWLSGAIVRVGLSVFLLVDMLPIRQARARNWLIIAIIFSFVIISMIPVNEYTFYLWMYEYYFPISLLVVMSVFFVWLFISLLGRPAKKEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY09</accession>
    <name>A0A398CY09_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="14">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="14">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pheT</name>
        <name evidence="19" type="ORF">D3H35_09215</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="14"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04111">
        <property type="protein sequence ID" value="RIE04111"/>
        <property type="gene ID" value="D3H35_09215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="40"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="18">
        <location>
            <begin position="411"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="721"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RIE04111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="815" mass="88134" checksum="054138BDAE05BFF8" modified="2018-12-05" version="1">MNVSYKWLSDYIDLDGIAPQELAEMLTRGGIEIDSVPSRNAGVTKVVVGFVKTREKHPDADKLSVCTVDAGLGEDLQIVCGASNVAAGLKVPVAIVGAKLPGGLDIKRAKLRGVESQGMICSARELGINDKLLPKEQQEGILVLPEDTQIGLDILDVLALNDSILELDLTPNRSDCLSMLGVAYETAALTGRSIRIPDPELDLYPTPDKTSDLVRVTIGAPELCTLYTARYVKGVKVAPSPLWLQNRLIAAGVRPINNIVDITNYVMLEYGQPLHAFDAAKVAGGHIDVRLARAGETLVTLDDQERKLEPHMLVIADAEKAIALAGVMGGANSEVASDTVDIILESAKFDGGNVRRTSRQLGLRSEASARFEKEVDTGRVRAALDRAAGLIAKYAQGLVTEGAAEAFVSQQEPAVIAISLGRINGMLGTSLSALEVKTIWSRLGFSAEQTGEDAWSVTVPTRRGDIARDVDLVEEVARLHGYDNIPTTPIEGPTTTGALTNAQSIRREIRKLWTHAGLHEAISYSVTSAGRTALFAELGEGAKPIPLAMPMSEERSVLRTVLLPSLLEAAAYNLTRRNSDIALFEIGSVYHTDEAVLTRLPNEKPRAALLLSGNRTPAAWNRKAEPFDFYDAKGLLELAFDRLGLSGRVSFEAASPEGFHPGRTAAVRFRTERGLETIGFVGQIHPDLQRDFDLTDSFAAELDLATVYEYADRAIEYRALPRFPAVERDVAVVVGLGVTGAELTGTVREAAGELLQSVRVFDVYTGERLGGDKKSVALALVYRHAERTLTDEEVTESFSRIVEKLEQTFGAELRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY12</accession>
    <name>A0A398CY12_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CCA tRNA nucleotidyltransferase</fullName>
            <ecNumber evidence="8">2.7.7.72</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_04105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04677">
        <property type="protein sequence ID" value="RIE04677"/>
        <property type="gene ID" value="D3H35_04105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052928">
        <property type="term" value="F:CTP:3'-cytidine-tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CTP:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016437">
        <property type="term" value="F:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032810">
        <property type="entry name" value="CCA-adding_enz_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13735">
        <property type="entry name" value="tRNA_NucTran2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="5">
        <location>
            <begin position="27"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_RNAbd" evidence="6">
        <location>
            <begin position="174"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_NucTran2_2" evidence="7">
        <location>
            <begin position="264"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="447" mass="49247" checksum="C28976662DA1B9F8" modified="2018-12-05" version="1">MAAVDGEALWAAGLAVVRRLREAGFEAFLVGGCVRDRLLRRAVHDIDIATSALPEEVMSTFARTLPTGLQHGTVTVMENGVPFEVTTYRHETGYSDGRRPDEVTFVRDIREDLARRDFTMNAIAVGFEGETIDPFGGERDLSAGLIRCVGDADSRFGEDALRMLRAVRFAAVLDFRLALSTWRGIKRQRERLKHVAMERVAAEWDKLMASDKPDRGAALLIRSGLLANVKDPLPDTLASVKPDAIDIRWHCVKECRLSEADDIDVRWAAFLSAAGCGADEAEQLCRKLRLSSQRTKRISGVIGFDRLWSDRLMAVAGSAGKKAFDETANEQANAVQLSSLRASWVKLALRFGRSTAEDWLKMTKCRPVAYSLLAYAKDWTNEISVWKAAELAVRGDELSRSLAKAPGPWIAELLNELLELVALDRLGNDSESLLAAARAQMDGGNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY31</accession>
    <name>A0A398CY31_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000004">
        <property type="protein sequence ID" value="RIE05448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05448">
        <property type="protein sequence ID" value="RIE05448"/>
        <property type="gene ID" value="D3H35_00310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017410342" evidence="1">
        <location>
            <begin position="23"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="277" mass="31512" checksum="ED2F8C77CE34400E" modified="2018-12-05" version="1">MAIVVAASALFGLSKGYPHAFAAGSPWSDPVVVSVRVSPDATYETRLAVGHLHIGQSSQQREEDSSKFAPILTDIYVRVSHGGLPKLYRLESSGRLWNEEERLNVSLPEKLSAKLLKEADKARAAHYGEAIAWKEAKRILPRKSVFKVMDMKTGLVFRVQRRAGSDHADVQPISREDTKIMNEIYGGQWSWNRKAVVVLAAGRRIAASMNGMPHGATEYRTTAFPAIFAFTSRRVRRTNRPYPIRPMNSWFTERRETRELIWIPHLRPYWRAAWSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY92</accession>
    <name>A0A398CY92_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamine synthetase</fullName>
            <ecNumber evidence="5">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glnA</name>
        <name evidence="7" type="ORF">D3H35_04625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Oligomer of 12 subunits arranged in the form of two hexagons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04767">
        <property type="protein sequence ID" value="RIE04767"/>
        <property type="gene ID" value="D3H35_04625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001637">
        <property type="entry name" value="Gln_synth_I_adenylation_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00182">
        <property type="entry name" value="GLNA_ADENYLATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="6">
        <location>
            <begin position="103"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="2">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="442" mass="50030" checksum="8EF26A99AE5F68BE" modified="2018-12-05" version="1">MSYSREDIVRIAKEENVRFIRLQFTDLLGTIKNVEIPVSQLEKALDNKMMFDGSSIEGYVRIEESDMYLYPDLDTWVIFPWVNQNKVARLICDIYMPDGTPFAGDPRGILKRALQEAEEMGYSALNVGPEPEFFLFQTDDKGNPTTDLNDQGGYFDLAPTDLGENCRRDIVLTLEEMGFEIEASHHEVAPGQHEIDFKYAKAIKAADQIQTFKLVVKTIARQHGLHATFMPKPLFGMNGSGMHCHQSLFKGKENAFYDANDKLGLSTVARQYMAGMLHHARGIAAITNPTVNSYKRLVPGYEAPVYVAWSASNRSPMIRIPASRGLSTRIEVRNPDPAANPYLALAVMLKAGLDGIKNKLSLPAPVDRNIYVMSEEERIEAGIPSLPINLQDALNEMLRDNVICDALGDHALSHFYELKEIEWDMYRTQVHQWERDQYLTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYC6</accession>
    <name>A0A398CYC6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04807">
        <property type="protein sequence ID" value="RIE04807"/>
        <property type="gene ID" value="D3H35_04885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="170" mass="19741" checksum="CE68AA0C98744D59" modified="2018-12-05" version="1">MYALNFDRFRELSALEEGQEFREKMESAGYSSFYSFVEQFRRELQAYTDHSAAGVLLLIDRGRRLFPEPGRFSPSWDALWDELESVCMAKNETLAAIAPSEREGEWQVLIDNPYLPQQVVCYPALAFVDAVYLYAYFLRDLKPNEHLRLQKITPFLVRTGNRHASVFPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYD8</accession>
    <name>A0A398CYD8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative metal-dependent hydrolase D3H35_05000</fullName>
            <ecNumber evidence="5">3.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_05000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Possible metal-dependent hydrolase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the metal hydrolase YfiT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.-.-.-" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04827">
        <property type="protein sequence ID" value="RIE04827"/>
        <property type="gene ID" value="D3H35_05000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01256">
        <property type="entry name" value="YfiT_hydrol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023774">
        <property type="entry name" value="Put_metal_dep_hydrolase_YfiT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DinB_2" evidence="6">
        <location>
            <begin position="34"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="176" mass="20137" checksum="D173CCF1613A192B" modified="2018-12-05" version="1">MSTDMRFPIGPFLHEGAIDSTQRDAWISDIEELPEKLATALIGLNDDQLDTPYRDGGWTVRQVAHHLADSHMNSFIRFKLALTEEHPSIKPYFEEKWALLEDTVKAPLALSLELLRGLHGRWALLLRSLTEDDFSRTFFHPGSQTIVPLSEALGTYSWHGKHHVAHITKLREKMGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYW5</accession>
    <name>A0A398CYW5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage II sporulation protein M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05027">
        <property type="protein sequence ID" value="RIE05027"/>
        <property type="gene ID" value="D3H35_02440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="210" mass="22576" checksum="FB9E95135017893B" modified="2018-12-05" version="1">MNGTGEIGMFSRVALLRSWKEIRPYFIFSIILFFAGTVAGGSPNAASGWLEAQLNGISVIAETAAKSDNPRLALFLLIAFNNVIKAIIVMCVGIFGGILPVIMLVANGMIMGYLLVDQSERGYNMFLIIVKGILPHGILELPAIFLACAFGIRFGLTFARGIGRSAIGKERPWQPFVNTAAGSVPALVFVTGTLIAAALIESTFTFWLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ19</accession>
    <name>A0A398CZ19_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YhcN/YlaJ family sporulation lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04481">
        <property type="protein sequence ID" value="RIE04481"/>
        <property type="gene ID" value="D3H35_06375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019076">
        <property type="entry name" value="Spore_lipoprot_YhcN/YlaJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09580">
        <property type="entry name" value="Spore_YhcN_YlaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="169" mass="18252" checksum="36F2090D5554AE6F" modified="2018-12-05" version="1">MASLVGAAGCTKKQSAPLHQSQVKVQNTVQGTGNLVKDRKAVAAHLEMLARGVAGVRNANCVVFGKYAIVGIDVDEKLERSRVGTIKYSVAEAFRKDPYGIDALVTADMDLAQRLREIRADVRQGRPVAGFSEELADIVGRLVPQIPRNIVPPEKPENTGVNNRLQPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0Z3</accession>
    <name>A0A398D0Z3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome C oxidase subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_01985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05161">
        <property type="protein sequence ID" value="RIE05161"/>
        <property type="gene ID" value="D3H35_01985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13913">
        <property type="entry name" value="ba3_CcO_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034214">
        <property type="entry name" value="Ba3_CcO_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="4">
        <location>
            <begin position="65"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="156" mass="17199" checksum="1E2B6EF2C66C00AE" modified="2018-12-05" version="1">MHIHRLEKIWLIVGVSMLIVFLGVIGVGAFAMGMQPPSGHQHKIDPDKVSETAPFDKPGLEKIGDNEYNAVMVAYTFGFNQEKMEVPAGATVHFQISSSDVVHGFEIPGTNVNMMVVPGEVNHLTYTFTKPGEYLILCNEYCGIGHEYMSTTLIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D197</accession>
    <name>A0A398D197_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_01760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05271">
        <property type="protein sequence ID" value="RIE05271"/>
        <property type="gene ID" value="D3H35_01760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005690">
        <property type="entry name" value="GerBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="525" mass="58313" checksum="441EFC50F546DDF7" modified="2018-12-05" version="1">MPFWKTHRSPAQNAGTPDKAFVKPLHASLEQNILEIRQSLGNSTDILIREIRLPHTADGKIGVIYTDGLADVQAISDFIMESTLLDVRFTPDSDGEPPLSSQVFHALKDRVLTIGSIRAIADFNNLFHALLSGDTIILIDEYNEGMAASTRGWKDRGVSEPSSEAVVRGPREAFTESLRTNTALLRRKIKDPNLWLETKPIGRVTFTDVGIMFIKGIANDKVIEEVRLRLNRIDIDGILESGYIEEMIQDDRWSPFPTVYNSERPDVIAAELLEGKIAIVVDGTPFVLVVPALFVSFLHSAEDYYQRADISMLIRLIRYVGLMISLLGPSLYVAITTFHQEMLPTELLINLAAQREGVPFPAFIEALMMEITFEILREAGIRMPKYIGATISIVGTLVIGQAAVQAGIVSAAMVIVVAITAISSFVLPAYNMSISLRMLRFPLMALSASFGLFGVIVGIIALVLHLCSLRSFGVPYMSPFAPFIPEDQKDAIFRLPQWMMLTRPRLISQSNRTRNSSTPPRKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1K7</accession>
    <name>A0A398D1K7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-layer homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_02735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05064">
        <property type="protein sequence ID" value="RIE05064"/>
        <property type="gene ID" value="D3H35_02735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013378">
        <property type="entry name" value="Listeria/Bacterioides_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042229">
        <property type="entry name" value="Listeria/Bacterioides_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09479">
        <property type="entry name" value="Flg_new"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02543">
        <property type="entry name" value="List_Bact_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017320779" evidence="2">
        <location>
            <begin position="32"/>
            <end position="1987"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="1794"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="1855"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="1921"/>
            <end position="1984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1553"/>
            <end position="1583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1987" mass="205682" checksum="3E7E103DF69980EC" modified="2018-12-05" version="1">MKKIRKRISSLLLSVCMVLPMLPVLPTMAFAAGEEFSLPTGQTYYFDLSGEADHIGTINTAVPDATLHYVPFTYVGTINAYSLDSSSSDHSSASETATASNRNLFVADYALSHSVSWNTLNGNGLIYGKTYDTNYTLRSLSMGNITGAVGSPTTNEWDRILDKDASLIKNWSIRSFGQDTNTMNWSARVARGGSGGVRYALGIQVNTINAGYGFRPALEVLNAGTLGANGLTAVTLHLGGGSFDSKPSIQVVSAGGHFTAPSGTGLTPPTGKILDEWNTAADGSGTSYEAGASVPNTVTTLYARWGTTPGGTYYFDLSSEAGDIGTVNAAVPDPTLHYVPFTYAGKINAYSLDSTSSGIMNSSVAAVASNRSLFVADYVVSHSVSWSTLHTNGLIFGKTFDTNYTLRSLSGGSDNSSGITPTANEWDQILGKNAAWIKGQSIYSWTQDTFAYSGTARIVRGPSFSPALGTTENTNIGWRPALEVRNAGTLWPNGVKDVTLDLGDGSVNGENRIHIVSAGDHFTAPSGTGLTPPADMTFDKWQKTGDASTTYIAGQTVAYTDGLGLTALWEYITAPEATPTIAIDYADEQLTGFMGSGSYTIDGTPIAPVSGKLDVAGYIGTAIAIVKKGNGTTTVDSEAQDLVVPARPATPTSVGVNPTTISGTGKITGATAALEYKASAGAWTDVTGTEIDGLAAGTYYIRVKATATSFQSAEQTITITALTPGAEAMPTIEIDYADEQLTGFMGSGSYTIDGTPVAPVSGKLDVASYLGTTIAIVKKGNGTTTVDSEAQDLVVPARPATPTSVGVNPTIIGGTGKITGVTVTMEYKASAGVWTDVTGTEIDGLAAGTYYVRVKATATSFQSAEQTITITALTPGAEATPTIAIDYADEQLTGFMGSGSYTIDGTPIAPVSGKLDVAGYIGTAIAIVKKGNGTTTVDSEAQDLVVPARPATPTSVGVNPTTISGTGKITGATAALEYKASAGAWTDVTGTEIDGLAAGTYYIRVKATATSFQSAEQTITITALTPGAEAMPTIEIDYADEQLTGFMGSGSYTIDGTPVAPVSGKLDVASYLGTTIAIVKKGNGTTTVDSEAQDLVVPARPATPTSVGVNPTIIGGTGKITGVTVTMEYKASAGVWTDVTGTEIDGLAAGTYYVRVKATATSFQSAEQTITITALTPGAEATPTIAIDYADEQLTGFMGSGSYTIDGTPIAPVSGKLDVAGYIGTAIAIVKKGNGTTTVDSEAQDLVVPARPATPTSVGVNPTTISGTGKITGATAALEYKASAGAWTDVTGTEIDGLAAGTYYIRVKATATSFQSAEQTITITALTPGAEAMPTIEINYADEQLTGFMGSGSYTIDGTPVAPVSGKLDVASYLGTTIAIVKKGNGTTTVDSEAQDLFVPARPATPTSVGVNPTIIGGTGKITGVTVTMEYKASAGAWTDVTGTEIDGLAAGTYYIRVKATATSFRSVEQIVTLTDPAPVTHYTVTVINGGTGASGSGDYASGDTVSIQAGTRRGYSFNGWTSSDGVTFADASGVATTFAMLAHNVTVTATWSGNGGSGGGSSSTAPSMSITIDKKPSQPTSATTSLNATVDENGNASVTLTESQVKALIDAAKEDAQNKGNTVDGIGIACNIQFGAAGISFSVKLEEGALALLEKEGVKRFAVNTSLVSSTFDQTAIQEMKSQASGDVTITASPVTKLSDAARVLIGSRPVYEITVSYQKNGKTEYVTNFGKGTVTLGFSYKVDLGEKKTVNLYAVYVNKDGKPQILIRSRYDNGKLAFSRNSLSIYGVGYLEPARAYSDTAKHWAKENIDFVVSRGLIAGTSTETFSPNTAITRGDFLMALGKLSGVDMSGYKQSSFTDVSSTNPAMPYIEWAVQNKIVQGVGNNRFSPDSPITREQMAVMMAGFTKVIGYKLPVSRQTITFADGAKISSWAKEAVKAIQQTGVVEGKDNNRFDPAGNATRAEASTILRRFVEFVIDEGTPPLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1N8</accession>
    <name>A0A398D1N8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000006">
        <property type="protein sequence ID" value="RIE05411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05411">
        <property type="protein sequence ID" value="RIE05411"/>
        <property type="gene ID" value="D3H35_00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="147" mass="16193" checksum="A052DEE845474A83" modified="2018-12-05" version="1">MVAERKPAAVTTSAARPSVSMNLATSPLSGFPATDTRHDEFRKSELDRVFDLLLQVLFQLLRLVHGQSDVRGRCMETVVGESLLQIFGGNSVIPASSTFLYPISAICLMVQGSLFPARSRGIQLNAQLRFTHLFIHQSIVRVSSLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D2E5</accession>
    <name>A0A398D2E5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_01610</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05244">
        <property type="protein sequence ID" value="RIE05244"/>
        <property type="gene ID" value="D3H35_01610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="68"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="135"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE05244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="364" mass="40298" checksum="6335D4F552CB6F07" modified="2018-12-05" version="1">MKKLRIRTFSLLSLLLILLLPWIFLLTSRLIGAGTLNFEDGKPNAYQMIAGMTGLMLAFFIVGFEMRRFLLNPLEKLGLAARRISAGDRDIRLPKSGIAEIAEVSDAFNLMVDGLREANLKQRASEEERRFVIAAIAHDLRTPLFSLRGYLDGLEQGIAQSPEKMAKYVAVCKEKSAQLDRLVEDLFTIAKLDYAENELNDRSFDFKLVLSEAIETLRPTARQKQVSIIANLPTQDCFVNGDSHLLERAIENLLDNAVRHAPNQGKILVQCRQDGPVVTFAVQDSGPGFNDEELQRAFDPLYRGEQSRNRSTGGAGLGLTISQRIIRRHGGELTIANHPDGGALLSGRLPMTLSSATTSNDSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CAK5</accession>
    <name>A0A398CAK5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00176">
        <property type="protein sequence ID" value="RIE00176"/>
        <property type="gene ID" value="D3H35_29485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041380">
        <property type="entry name" value="Acetyltransf_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17668">
        <property type="entry name" value="Acetyltransf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="303" mass="35091" checksum="6B91DFFCA6733B04" modified="2018-12-05" version="1">MMTLRNVRENEFDDLMALWQFAFQIQMPPERVEKERESFRADNHWGLFDENGRLLTNLSILPLEVWIHGVRMKMGGVASVSSWPDARRQGGVTKLLHHALRKMREAGQTISMLHPFSVPFYRKYGYELTVTRKQYTIETKHFPPRADVPGTVAIVPKRSELLNDVYEQYAAKYSCTLARTDDWWERKVLSKPGVAALYRNPDGIAEGYLLYEAADRKMRIHEWVHTTETARAALWSFIGNHDSMIDQLVMMARRTMTCLSCCRSRGSSKSCCLISCRVSWMWSGSSSRIPLRLPSGRMYWRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CC39</accession>
    <name>A0A398CC39_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xanthine phosphoribosyltransferase</fullName>
            <shortName evidence="1">XPRTase</shortName>
            <ecNumber evidence="1">2.4.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">xpt</name>
        <name evidence="3" type="ORF">D3H35_28365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine</text>
            <dbReference type="Rhea" id="RHEA:10800"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.22" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00343">
        <property type="protein sequence ID" value="RIE00343"/>
        <property type="gene ID" value="D3H35_28365"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00602">
        <property type="reaction ID" value="UER00658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000310">
        <property type="term" value="F:xanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046110">
        <property type="term" value="P:xanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01184">
        <property type="entry name" value="XPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010079">
        <property type="entry name" value="Xanthine_PRibTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01744">
        <property type="entry name" value="XPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="2">
        <location>
            <begin position="50"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phospho-alpha-D-ribose 1-diphosphate binding" evidence="1">
        <location>
            <begin position="128"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="189" mass="20542" checksum="A9E6199CEED611A0" modified="2018-12-05" version="1">MELLKKKIREEGIVLSEQVLKVDSFLNHQIDPVLMLEIGRTFAGLFADSDVTKVLTLESSGIAPAVMTALELKVNVIFARKRKSLTLRDGLFTEKVYSFTKQEESEVSVSGKFLSPGDRVLIVDDFLANGEAALAMARIAMQAQAEVAGIGIVIEKAFQPGGAKLREQGYRVESLARVASLGNGQVLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCE0</accession>
    <name>A0A398CCE0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_28695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00393">
        <property type="protein sequence ID" value="RIE00393"/>
        <property type="gene ID" value="D3H35_28695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039650">
        <property type="entry name" value="HdrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498">
        <property type="entry name" value="PTHR43498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="427" mass="46409" checksum="FC1C5BE263F07787" modified="2018-12-05" version="1">MKIHHSQEVDVAVLGGGAAGIMAATSAARHGMKVLLVENQGCLGGSRTAVGVDTFYGFYTPGNVKKKIVGGIPDEVIERLRKENAVFERPNTYGAGTGLTYDVEVLKLVYEDLVLGSDVKLLYHTSACYVNSSNGTIESVILANKQGLTEIKAKRYVDTTGDADIVYRANGQFIPLQENETLQSLSTIFFMANVDTERAGNVKHSELVEMMKSAVEEGGYELPRLDGSYHNTPNAGVIQANMVRVPDVDATDPYLLTLAEVEGRKQVRQYARFLKDKVPGFENAFLMSTGQHIGVRETRKIKGHYILTEEDVVEGKKFVDSVACCAAPIEDHNSSSGTRWVYVKNDEIYNIPYRSLVPSNLNNVIVAGRCISATHGAQASVRNSAQAMALGQAAGTAAALSIGRGEYFPELNIKELQTRLIAQKAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDD1</accession>
    <name>A0A398CDD1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_26250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00703">
        <property type="protein sequence ID" value="RIE00703"/>
        <property type="gene ID" value="D3H35_26250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017277256" evidence="2">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="60" mass="6235" checksum="3F32642AD6774BA0" modified="2018-12-05" version="1">MKLQHGKQAMKIANVLLALTLLFVFSGCGSSGSSSQSTPSGSAAALPRSRHRPVRLSPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDQ2</accession>
    <name>A0A398CDQ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01316">
        <property type="protein sequence ID" value="RIE01316"/>
        <property type="gene ID" value="D3H35_23325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017275562" evidence="1">
        <location>
            <begin position="34"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="372" mass="40730" checksum="61D7BF0BDC2333B6" modified="2018-12-05" version="1">MVKSKVCLSLMALLLMTAVVLSGCTSSKTPKEALEASFAKSSDIKSYSFKGTLKVNELNLPDQAVDEENSFGTSMGIKLLKNADLSWTGVYQAEPMMSEVNLSLMLKGDMPITINIPVVMNDKKIWVKIPSIPIFPLPDTITNKFLELDLEQLAKESGQPIPKVDQNTTKKLGNDVLGIVFNNVEEKDYLSSIKPKEAGLPEDAGLDQAIQLHVTKEQLEPFIKTAVEKIAPEIIDLLSKNQAYKDAFQLKQEDLDKYKKELSEAQSGDLSKKLEEMKKTLKALDLKANIGIDGDDYPVYTDFALKAGIEQGGKSGNIDLKAVSQMSDINKEVKFTIGVPKDIITMEQLQEQLGGLFGNLGGIGQELEGAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE09</accession>
    <name>A0A398CE09_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01416">
        <property type="protein sequence ID" value="RIE01416"/>
        <property type="gene ID" value="D3H35_23905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010375">
        <property type="entry name" value="CdAMP_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38456">
        <property type="entry name" value="PTHR38456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06153">
        <property type="entry name" value="CdAMP_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="109" mass="11805" checksum="FBA5B37F52685A20" modified="2018-12-05" version="1">MKLLIAVIQDKDSNRLSNSLIKEGFRATKLASTGGFLRAGNTTFLIGIEDDRVQSALDVIRANCKVRDQLVTPVSPVSGAADSYIPFPVEVQVGGAAVFVLPVERFEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEA2</accession>
    <name>A0A398CEA2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperonin GroEL</fullName>
            <ecNumber evidence="6">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Chaperonin-60</fullName>
            <shortName evidence="6">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">groL</name>
        <name evidence="6" type="synonym">groEL</name>
        <name evidence="10" type="ORF">D3H35_25710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00960">
        <property type="protein sequence ID" value="RIE00960"/>
        <property type="gene ID" value="D3H35_25710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE00960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="544" mass="57524" checksum="B6CAEDCFAC38192A" modified="2018-12-05" version="1">MAKEIKFSEDARRAMLRGVDALANAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIELEDAFENMGAQLVKEVATKTNDVAGDGTTTATVLAQAMIREGLKNVTAGANPMVVRKGIDKAVRAAIEELRSISKPVEGSTSIAQVAAISAADDEVGQLIAEAMDKVGKDGVITVEESKGFQTELEVVEGMQFDRGYLSPYMITDTDKMEAVLDNPYILITDKKISNIQEILPVLEKVVQSGKQLLIIAEDIEGEALATLLVNRLRGTFTCVGVKAPGFGDRRKAMLQDIAALTGGTVITEELGLELKSATVAQLGSARQVRVNKENTIVVDGAGNKADIDARVSQIKAQIEDTTSDFDREKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNATRAAVEEGIVSGGGTALVNVYSAVAAVNAEGDEKTGVNIILRSLEEPIRTIAANAGQEGSVIVDRLKKEKVGIGYNASTGEWVNMFEAGIIDPVKVTRSALQNAASVAAMFLTTEAVIADKPEKDKPAGGMPGGMGGMGGMDMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEC0</accession>
    <name>A0A398CEC0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1934 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21695</name>
        <name evidence="2" type="ORF">D3H35_21745</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01053">
        <property type="protein sequence ID" value="RIE01053"/>
        <property type="gene ID" value="D3H35_21695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01057">
        <property type="protein sequence ID" value="RIE01057"/>
        <property type="gene ID" value="D3H35_21745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015231">
        <property type="entry name" value="DUF1934"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09148">
        <property type="entry name" value="DUF1934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="107" mass="12588" checksum="D3927F42B77B96F5" modified="2018-12-05" version="1">MPRDGASDEKALVRIRLESDAGGEKQEQSLEGEWYSKNRTIYLRYEETEGANLVRTLLSWKDGRLRLVRQGDVESEQIFSAGGRHSGYYRSDNVQFRWRRRRLFSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEH2</accession>
    <name>A0A398CEH2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_22050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01103">
        <property type="protein sequence ID" value="RIE01103"/>
        <property type="gene ID" value="D3H35_22050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="1"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="380" mass="41138" checksum="DB82C0A6881B0EDD" modified="2018-12-05" version="1">MTKGLVKVLCFGLMAFLGFYLSAFQRMLDYIAQDYSLSKVLMGFTATAHFVGILCGSLATGERSDRFGRKKVIGSGCLFFLLGLLVIWLAPAAYAVLVGIFLTGVGFGILSGSISTLLTDFEEGDANRVLNISQMFFSIGTVIGPFMAVAAMEYADDWKLIYGLSFLLILFFSFLFLKYPYPRRSVADATEETYTSLLLKQKRFLLLGLSILMYVGIESGMGFWITTYIRESGSTSAWYASAVLSAFWGGTIVGRYAVSRFSIKLHEIVVISALLSAAFLLVIVLSGSAAASFCAMFGVGLGFAGIWPLIMALARAYYPKYTGTAFGLLMACCALGGIFIPLAMGIIGKAVGMNAALSFGFVPILIIVCIHLYLKRTSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEZ3</accession>
    <name>A0A398CEZ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_13210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01756">
        <property type="protein sequence ID" value="RIE01756"/>
        <property type="gene ID" value="D3H35_13210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="211"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="408"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="495" mass="53790" checksum="4B48B98BFF784E9A" modified="2018-12-05" version="1">MEGWRLVKSDNTLYRRNKLLVKIIWGMLILGIGVDMLTAAPVKSVLVLVAVGSVTCTVATVLTYKRWLEDYVMYIISAIITVLTTLLILTGPIITTYFLVYVNLAIMTLYGSFRATAFSAFLGVGLSAYLFVSPYRSELFADNAPLTIFLYLGMIAAPLLASAKFSERLQLASADDRENALEEKTRAQSIVAKVAASLHTLNGFSANLKQNMTSTGEISREVTAAFTEIAASSRNQASDIAEIGESSRSIDGAVEELAKSSTEMRKLSLESARLTGIGSEEALKLGVQMSQLEQTIDGSVLLMRQLNEQSKQVGEIVATIKHISTQTNLLALNAAIEAARAGEHGKGFAVVSNEVRKLAETSQQSTEQIERILDAIRRKTDEASEQVISGQQTVALSREAAGRVAEALDALTEDSGRVERQAEQVNRSADELREQYAKIAGRITNISAITEENRASIEQISVSMQTQDSQIAEIEDSFLQLDKLASDLSKTAESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFI3</accession>
    <name>A0A398CFI3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_24325</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01483">
        <property type="protein sequence ID" value="RIE01483"/>
        <property type="gene ID" value="D3H35_24325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="21"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="337"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="371"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE01483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="583" mass="64875" checksum="FCDBA0F18BA98328" modified="2018-12-05" version="1">MFIVLRKLAWFFKMQWKRYTVAISLLIVVGILEIIPPKLIGVAIDGIFDGTLTGGGLTKLVALWIGLILVGYGLSYIWFSKLFGGAFVLERFMRKRMMKHFMRMLPTFYERNRTGDLMARATNDLGAVSVTAGFGILTLIDSTLFMTTILIVMAGLISWKLTIAAMLPLPLLALALKHFGKKIHERFMKSQDAFGEMNDEVLESVSGVRVIRAFVQEEADQSRFREKTEDVYRKNVAVAKVEALFEPTVKILVGLSYLIGLCYGAVLVFRSEITLGELISFNVFLGMLIWPMFAIGELINIMQRGSASLDRINETLGVHPDVVDSEQPIAVEVPESIAFERVTFQYPSSSIENLIDISLTLKRGQTLGIVGRTGSGKTTLLRQLLREYPPGGGQLSIGGAPIEAIEMNRTRSWIGYVPQQPILFSKTIRENIEFGGADKAVTEEKLNRALELASFRKDVAFLPDGLETLVGEKGVALSGGQKQRVSIARAVVADPEILMLDDSLSAVDAKTEAEILEGIRRERAGKTTIITTHRLSSVQHADWIIVLDEGRITEEGTHEQLLQQGGWYKEQYDRQQLATIVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFT7</accession>
    <name>A0A398CFT7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2634 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01295">
        <property type="protein sequence ID" value="RIE01295"/>
        <property type="gene ID" value="D3H35_23205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020288">
        <property type="entry name" value="DUF2634"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10934">
        <property type="entry name" value="DUF2634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="133" mass="14600" checksum="62C1B3E542324F7D" modified="2018-12-05" version="1">MIPTGGQIEADELQEVRQPSRTYRLDWNMQRAAGTVDGLEAVKQAVRKILQSERYNFLIYSFDYGMETAGAAGRSPEIAKSELGRCIREALLQDDRISDVTDMQVTVNGDSALATFTVESDFGAFEGGVTVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG84</accession>
    <name>A0A398CG84_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Recombinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_24460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01510">
        <property type="protein sequence ID" value="RIE01510"/>
        <property type="gene ID" value="D3H35_24460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="3">
        <location>
            <begin position="96"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="458" mass="52126" checksum="C5FDD5DA60BB2F79" modified="2018-12-05" version="1">MLADAERGKFDLVLIWRISRLARNLTDLLGIVEHLNRHKVMLYSLKEPFDGTPIGQFVLQMHGARAELERSNIADNVRAAMNQRSKSGIWNAGNSVLGYRWTRDPETTLGQVQVVPEEAELVNHIFEWYASGELGYKAISNRLNHASRLTKLGKPFSVQLIRNILNNHNYIGLVRYNKTEHIRTGGDVAIGWAQGTHRAIINLDLWNRVQTLLVERFAPPLRKIERSYPLAGLLKCPLCGYSMIPWHVNQMRKDGTRKTNHYYQCSTNNSKGSAVCRSNLVRADNVEQWFFEQLRMLLTAPEALETIVAATNAKHQSDTRPTLEEVRQIEVLLKELASQKEVLYRSFESGALSKDEFAATIMEVKLQINEAQASKERLEAVLVASEKDEINPDQIRLALSRLRQLLETSPGEQQKRLLRLLVDKITLPKDRDFRQATIHSTNALLNLQIPTLTEANSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGH5</accession>
    <name>A0A398CGH5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HindVP family restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_24915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01590">
        <property type="protein sequence ID" value="RIE01590"/>
        <property type="gene ID" value="D3H35_24915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009036">
        <property type="term" value="F:type II site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019044">
        <property type="entry name" value="Restrct_endonuc_II_HindVP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09519">
        <property type="entry name" value="RE_HindVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="359" mass="41910" checksum="A08DF282F986D776" modified="2018-12-05" version="1">MNRTQPTLYGITNSNRHGKDLFGKNQFNSAFPLSLACYMRDQGQKAVYLYLDENLKVQSKEVSFDEIFNSSLPNDQLRFDFESKYTPYQEFAYNDIKGIDLVIKHEDEWLRPLEVKLTVLPDNTTGKEPESNWGSEMVIRPASTLYCALGIVHSCQDVLREIRDMFEPVCHRIRNWSNHEEIFNRRTDLLGVLNDFQKTYHSKQKPFLMQPIWKTNGVNPTLSDDAFDIFVWSDFALCRTFLDRSEGIQEITRFYRSSARLAKILYELSTRGKANIEEIYTEMAFGLQTDKEFALNGKMTRDYMKHPRRINPAVKKEVLTKIIQNGGVKLLSPERRFDQSVYFTTAHLFEEKNEGSELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGJ4</accession>
    <name>A0A398CGJ4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9 11">Uracil-DNA glycosylase</fullName>
            <shortName evidence="9">UDG</shortName>
            <ecNumber evidence="4 9 11">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ung</name>
        <name evidence="13" type="ORF">D3H35_29620</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9 11">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 11">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 11">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="4 9 11"/>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00199">
        <property type="protein sequence ID" value="RIE00199"/>
        <property type="gene ID" value="D3H35_29620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="12">
        <location>
            <begin position="49"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9 10">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE00199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="226" mass="25852" checksum="684CDAD1B8704F4E" modified="2018-12-05" version="1">MAILKNDWAPYLEQEFEKAYYLKLRQFLIEEYRTKTVYPDKYDIFNALHYTSLADTKVVILGQDPYHGPGQAHGLSFSVKAGISTPPSLQNMFKELRDDLGCYIPNNGHLLNWAQQGVLLLNTALTVRANEANSHKDRGWESFTDRVIEVINGKNEPVVFLLWGSHAQKKAELITNRKHLLIRSPHPSPLSAHRGFFGSRPFSRANQFLRTVGSREIDWQILSQMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGQ6</accession>
    <name>A0A398CGQ6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_29970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00259">
        <property type="protein sequence ID" value="RIE00259"/>
        <property type="gene ID" value="D3H35_29970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="136"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="353" mass="38749" checksum="B4E1A6F7F891AEF6" modified="2018-12-05" version="1">MNKIKVAIIGCGTIASNAHIKAYLGNPNAEIKYFCDIIAEKAEKAVADFSCGIAIEDYRIILEDPEVEAVSICTPNHVHASISIDCLRAGKNVLCEKPAARTYAEALEMQKVQHETGKVLNIGVVNRFNKGVNIIKTMIENGELGELYHVYVSFRAFRSIPGLGGAFTTKSIAGGGALIDWGVHFLDIVMYCSGDPLPRTVSGQAYSKLGKDMENYSYVNMWAGPPKYSGTYDVDDFVTAMIRTEGPTITLNGAWAQNIGVEEMYIDFLGDKSGIRLQYGADFKIYSARNGVLLETSAKYEQGDMFQNEIDSFLDCIRTGEKLPSHIDTVILTSQMIQAIYDSSEQKSEIVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH21</accession>
    <name>A0A398CH21_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01262">
        <property type="protein sequence ID" value="RIE01262"/>
        <property type="gene ID" value="D3H35_23015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="209" mass="24347" checksum="5A46A5569A872403" modified="2018-12-05" version="1">MEFFWYIVCSTVESCAFFIVMLFLFRFHSFQYIRSIFATSVLFSFLSYSLRVDLGFNNFFPLVTILVFAVYAFYILKIPLFWAVAMSLVSTITSFALETLMLLLYFIPGVGTLGDISSTSSRIFQVLYAIIVIPLSYFMYRRGIGFAFNFDKLKWRAENLVVFIIVIILVIAMFITFIQKNVFYAIVFALITTAFLLYLSFKKERDDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHP3</accession>
    <name>A0A398CHP3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_27120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00639">
        <property type="protein sequence ID" value="RIE00639"/>
        <property type="gene ID" value="D3H35_27120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="6"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="167"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="370" mass="42386" checksum="A1B689593B839785" modified="2018-12-05" version="1">MVPYIVERFRKIGWEMEMFSLPKRIRNKGQEEIEFDTFDWRPYAGNLVVERYIQTYKDYLWWTKLRLKEQKYDLIHAHHPIAALAMSRVFPDIPVVMTVHSSFERELMLNGRIEAGGAEEKFLTSIYRELEQRTSRLTTVSHSFAAYMGAFLDHPERIQVIPNGYDEKRFKPISHDNEVAQLVTVCRLVPAKGLDILLQGCAELRKRNRPFVLHMIGDGPIREELETMAQKLGIYDDTIFYGYMLHPEELLPFFDVFVLPSRAESFGSVFAEAALCLLALVGTNVGGIAEQIENGVNGLLVPPEDPVALADALETFITDPHFRYEMARAASNKAKKTYSLNRVIGELKRNYLSLTEGLDEGESVEETEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI46</accession>
    <name>A0A398CI46_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_26990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00829">
        <property type="protein sequence ID" value="RIE00829"/>
        <property type="gene ID" value="D3H35_26990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="450" mass="51742" checksum="34CF4301E5EFC5CE" modified="2018-12-05" version="1">MVSIWRQVLGREQIGIGENFFEIGGHSLRASAMASAVSKELNVDVRIGDIFRTSTIKALSNLIQNKEISSYKLITPADEREYYPQSSAQKLLFIQNQMNPQDKTYNMPKGYFINGELDRNRFELAFKSLISRHESLRTSFHWMTGEPVQRIHQDVEFEIDYWQADLDGVGSIVSEFVRPFSLDQAPLLRVGLIRLSEQRHMMLYDLHHIIADGLSMEILEREFIEIYHGKVLEPLRLQYKDFSEWQRNVFLNEQVAKQERFWLNRFSSEIPKLALPTDYPRPSYKSYEGDQVGFILDEKTTMSLKQLSLETETTLYMVLLSAFTILLSKISGQEDIVVGTPVAGRTHVDLANIMGIMINNICMRNLVDKDKIFMEFLKEIRQNTIEAYDNQTFPFEMLVEKLGVTAEPSRSVLFDAMFGLNSNLYSNSEHDTSNIEFIPSAVGNGTPSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIE5</accession>
    <name>A0A398CIE5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01822">
        <property type="protein sequence ID" value="RIE01822"/>
        <property type="gene ID" value="D3H35_13595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="117"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="364" mass="40741" checksum="4D6C79A6CF61527F" modified="2018-12-05" version="1">MIYLLIITAIVVAAYLVIKLYPPLGAKAAGDDRRSIDGSVNYADGRFVYPEPTPMDMSFKTMMGVMAEMLKGSPNRKPRKALPADTFNPLLLQNKNQAKAIWFGHSALLLQMNGLTLLLDPMFGSAPSPFPLLGGKRYGGKLPFEIEELPEIDAIILSHDHYDHLDYGSIKKLQKKVRRFFVPLGVGAHLERWGVSRERITEADWWDEAEFEGLKLVCAPARHFSGRSVNDRLSTLWCSWVIDGGGTKVFFSGDSGYGPHFKQIGERFGPFDLTLMECGQYDERWSLIHMMPEETVQAHLDVGGKLMIPIHWGAFTLAVHDWTDPVERVLRKAEQSGADVATPRIGQAVTIGAPEYPTSPWWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIG1</accession>
    <name>A0A398CIG1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3502 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00979">
        <property type="protein sequence ID" value="RIE00979"/>
        <property type="gene ID" value="D3H35_25820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022627">
        <property type="entry name" value="DUF3502"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12010">
        <property type="entry name" value="DUF3502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3502" evidence="1">
        <location>
            <begin position="237"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="376" mass="41886" checksum="6A84A21F8131B9ED" modified="2018-12-05" version="1">MDELLDKYGQDIKKKVDPRAWKAVTYNGKIMAIPAQTPYTQPIGFVFKKELVDKYQFDYKNVKTLKDLEPFLEKLKKNEPDITPIMAFARGGMAGVALLDYGSIIDGVVYDEKNGKPVLTLDVPDYVDHLRTVNDFYRKGYIAKDAAVKTDFLAEAKSGKYGVLKDSGGYTEDGSKSTALFGYPTVESLYGYPIISTDSMIQAATAISKTSKNPDRAMMLLNLIWQDKKLSNTLAYGLEGQNYTVKSGQGTDNPTIEAKSGAEQTWAIWHNWLGPLWDQWDSNWNSTKALEAMKKNNDAAQTSALLGFSFNSEPVKAEVAQVSAVFAEIKPILLTGSMPDFDKYIADAKQKLNNAGMDKIMIEVQKQIDAWKEANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIH6</accession>
    <name>A0A398CIH6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_27165</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ArsB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00648">
        <property type="protein sequence ID" value="RIE00648"/>
        <property type="gene ID" value="D3H35_27165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02040">
        <property type="entry name" value="ArsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017361604" evidence="9">
        <location>
            <begin position="27"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE00648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="255" mass="26868" checksum="1DF000CEEA636F3A" modified="2018-12-05" version="1">MAFPGLTAAAATVIVCAAAFAKTVKNDEASQANENDSAAEFPEPGSRISHVMLFRLSWIILALILLGYAFSETLGIPVSVIACAGAAVLWIAAAFFKAANSRELLLRTPWLIVAFALAMNLIVYSLYVHGATDWFGELLEPVAHAGTAASVFGSGLLFSLLAACMNNLPAVLVASLSIEHVQGSDMLPFASLLGMSVGAKLTPIGSLATLLWLGLLRSGGIRMTWGHYLRLGLPLTAAVLLLSLAALWLQTVLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIT9</accession>
    <name>A0A398CIT9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03206">
        <property type="protein sequence ID" value="RIE03206"/>
        <property type="gene ID" value="D3H35_19615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="258" mass="28031" checksum="CE796A4613ADD96C" modified="2018-12-05" version="1">MSLQGRVVLVTGASSGIGALTAKLLAERGAIPILTARSSDKLAELSASIRSEHAVFAMDVQREEQVSEVVAEVHRRYGRIDVLLNNAGYGEFVPFAEATMAHFQDMMDVNYMGVVRCSKAVLPFMLEAGQGHIVNVASIAGKLGTAKSSGYSATKHAVIGLTGALRQELRKSGILVSAVNPGPIDTPFFHRADPDGSYARNIGWFMMRPEKVARAIVSVIERRKPEVDLPWLAAAGIRINRLFPRWTDALMGKMLDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIW8</accession>
    <name>A0A398CIW8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FGGY_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000038">
        <property type="protein sequence ID" value="RIE03236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03236">
        <property type="protein sequence ID" value="RIE03236"/>
        <property type="gene ID" value="D3H35_12740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="16"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="158" mass="17493" checksum="8BD9210052922A62" modified="2018-12-05" version="1">MADGKGGVLVDAEGVYFLGVDIGTYESKAVLTNLEGRIVHHEVISHQMIVPKPGLAEHDADGVWWHDFCLLVERILQATRISSDQIKAIGCSAIAPAVLPVDREGKPFGRLFCTVSIRAPWRRFESWSIDSAMQCVSKVRQRFIYAGGRTEDPLDQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJD1</accession>
    <name>A0A398CJD1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00938">
        <property type="protein sequence ID" value="RIE00938"/>
        <property type="gene ID" value="D3H35_25590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="218" mass="23740" checksum="3F8E197DC6A085BC" modified="2018-12-05" version="1">MTTTTQATAAASLFDVIQDRRSVRQYDASVSIPREELTEILELATRAPSSSNLQPWRFLVIDSPELKEKLLPIANNQKQVVEASAVIAVLGDVESYKFADKIYTTSAEAGMMPVDVAKSFIERTVAMYSGLPPEVARSIIYTDGGLVSMQIMQIARAKGYDTVPMGGYNKAQFVEAFGVAERYVPVMLIAIGKAAAEGRPTTRLPIGDVAFFNELPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJF4</accession>
    <name>A0A398CJF4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_25755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00968">
        <property type="protein sequence ID" value="RIE00968"/>
        <property type="gene ID" value="D3H35_25755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="3"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="329"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="553"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="572"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="363"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="647" mass="72358" checksum="D10FD86B431571AB" modified="2018-12-05" version="1">MLLQASGIIKNYGVTPILSGVSLQVGERDRIGLVGVNGAGKSTFLRILAGELQADGGSVSKPKELRIGYLAQNGGLQGHLTLQEEMTSAFGPLLDQEKELRAMELRIANPNEQADPIKYESLLTQYADRSERFREAGGYEMNNRIRSVLHGMGFGEFAPDTAISSLSGGQRTRLALARLLLVQPDLLLLDEPTNHLDIDTLSWLEQYLRNYSGSMVIVSHDRYFLDATVTSIVEIERHAAIRYTGNYTRFMELKEADYSQKVKLFEQQRKEIARMEDFIQRNIVRATTTRRAQSRRNALERIERLEKPGTLKQASFSFATERRSGKDVLEVYDAAAAPQPDMSPLFHNVAFEVKRGERVALLGRNGVGKTTLLKALVGKTELRSGAYRWGTGISLGYYDQEQRELNPANTVLEEVWSAFPSQPEAEIRTVLGNFLFSGEDVRKSVGSLSGGEKARVALSKLMLLKANVLLLDEPTNHLDLMSREVLEAALEEYEGTLIFVSHDRYFLNRLTDRIVELHPDGAKHFLGNYDEMVAKKREMEEWLASSNAAASQVPQSASVGSASSANATSYEADKQAKRDQRAKQRKLEQAEADIAKLEEEIAALEEEMASPEVVTDYVRLREKQEAVESRRTALELAFAVWESAMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJP4</accession>
    <name>A0A398CJP4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_20130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02923">
        <property type="protein sequence ID" value="RIE02923"/>
        <property type="gene ID" value="D3H35_20130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017449626" evidence="2">
        <location>
            <begin position="24"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="479" mass="51955" checksum="F5072D23D14182CB" modified="2018-12-05" version="1">MAKLKKSLGLLLVISMIAVLVVACSKKNNGENASPSASPTGSTTSSPSASPAAPKVDEIYFLNFKPEIAEVYEKISKDYEAETGVKVKVVTAASGTYEPTLRAEIAKSDPPTIFQINGPVGYANWKDYTADLKGTKLYDSLTDKSLAVKSGEGVYGVPYAVEGYGIIYNDAILKKYFALADKAVTINSAAEINNFATLKAVVEDMTAKKDQLGIKGVFSSTSLNAGEQWRWQSHLANLPLYYEFKDNTAFDNTVLAGLAADEIQFKYGENYKNVFDLYINNSVTKPALLGAKSVTDSMAEFALGQSAMVQNGNWAWGQISGVDGNVVKSEDIKFLPIYTGVQGEESQGLAVGTENFFSINSKVSPEKQEASIAFLEWLFSSEKGKSYVSKDLGFIAPFNTINDNEKPADPLAKEVLAWMAKQGTTSVAWTFAAFPSEEFKNKFGAALLEYAQGGKTWDQVSTIVKDSWKSEKALAKSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJY7</accession>
    <name>A0A398CJY7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1304 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02452">
        <property type="protein sequence ID" value="RIE02452"/>
        <property type="gene ID" value="D3H35_17260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009732">
        <property type="entry name" value="DUF1304"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38446">
        <property type="entry name" value="PTHR38446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06993">
        <property type="entry name" value="DUF1304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="120" mass="13007" checksum="1EC3763F6118EC3C" modified="2018-12-05" version="1">MTLISAILVAVVALEHVYILILEMFMWTKPRAMRIFGTTKPFAEQTKALAANQGLYNGFLAAGLIWGLVHPDSAFGRQIQLFFLICVLVAAVYGGLSAKKSILVTQGLPALIALLFVLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK20</accession>
    <name>A0A398CK20_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M56 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_22695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01208">
        <property type="protein sequence ID" value="RIE01208"/>
        <property type="gene ID" value="D3H35_22695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008756">
        <property type="entry name" value="Peptidase_M56"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05569">
        <property type="entry name" value="Peptidase_M56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M56" evidence="2">
        <location>
            <begin position="9"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="652" mass="73310" checksum="8A28A80ED8C38D79" modified="2018-12-05" version="1">MRMETLFLKVLNMSITAAYVILAVLLIRLLLKRAPKKYSYLLWVVVLFRLVCPTSFSSELSIFNANPFDMTTAQKDGEVALSYVPADVGYMESPRVTVGIPTVNAILSDRLPAAVPAASVNPLQIWILLGTILWCLGVAALLIYSIVTFIRLRRRLATAVRLDNHIFESENIRSPFVLGFIKPRIYIPFGLGERERMHILRHEAYHLKRKDHLIKPIAFLVLAFHWFNPLVWLAFASMAKDMEMSCDEKVLSEIGAGKTKEYCTSLLSFAANYRFPSAGPLAFGETSVRERVKNALRFKAPKKGVVAFSAVACMIVVAACAANPTVNEMPKDTEKLYGSYSFEKQVYMNPLSSFIALEGHKEYYTLTENSLIITDEAGNQQKLATNYERTTVDKQEFNNSFMMNSIGVPDIASYKERYQYALTNPSASPAYRLYLLDDEMWLAKIRKDTANIQKSEYIWSIYKVSKLDGRVPVKAAIVGTRDGVDAFLALNKDFKSGYDTDTCYNITPAYMKENSEYRIFKYDQSSASFLLYEGNVYPLGEWFGGFGVTSMALADIDRDGRSELYFTYSWGSGLHRSHAAYFSPAAKQIVTLEYTHLNGDMLLTDNHDGSLSLFAAAISSVGGFVNFEMEGTEFISDIVYANGQISINREIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK46</accession>
    <name>A0A398CK46_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylneuraminate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01569">
        <property type="protein sequence ID" value="RIE01569"/>
        <property type="gene ID" value="D3H35_24795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="310" mass="34236" checksum="AEC9AFF06FD99C76" modified="2018-12-05" version="1">MKPYDLNKFKGVFIAMNSCYDEQGEVSPERAKKLARHYADIGVKGLYLAGSTGEGMLQSVEERKQILQAVMEEVRGELIVIAHIGAASTRDCVELTVHAESVGADAISAVPSIYYRISEKGVEEHWQAIIDSSSLPFIMYHIPATTGFHLSKDLLGKLAKQDKVIGVKITTDSTYELQQFKRIGGEDFILFNGPDEQYVAGLIMGAEAGIGGTYGVMPELFMKIEQCFAEGKIAEAQHWQIKVNEIITELVAFPSLYGASKLILKLRGIDTGIPRMPISPIPESDYSKIEALNHKILHYIEEAKSEGIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKU5</accession>
    <name>A0A398CKU5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_13635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01829">
        <property type="protein sequence ID" value="RIE01829"/>
        <property type="gene ID" value="D3H35_13635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="406" mass="44543" checksum="1C3051EEF3A23F90" modified="2018-12-05" version="1">MHNKRQSAHAGGQLDKQTLLLLAVNGLFITANALSGTFLGVYLWKESNDFILLGWFTLLTHAFMALTFWIAGNVAKEGNKMIVLRLGIGASASFYVLVLLFGKAAIQYVWLLGIVQGIAVGFFWLAFNVVYFEATNADNRDRFNGWSGVIGSVAGMVAPWCSGYLISKMAGESGYRVIFMISFGLFLAGIGVSFLLQKRAAAGNYDWLLTVRALRKPGAPWRPVVAALVAQGLREGVFGIVIGVLVYIQTGSEWKLGNFALITSAVGFASFYAVGKWLKPAWREKAMLVGTIVMTAVIVPFFFGVSFTTLLLFGIGVALFIPLYTIPMTSAVFDMIGKDEESARQRVEYVVMRELALNAGRIAGMAIFISTLYISRAPVVINWLLLLIGSAPMLSWYFMRRRLAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL26</accession>
    <name>A0A398CL26_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_20300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02950">
        <property type="protein sequence ID" value="RIE02950"/>
        <property type="gene ID" value="D3H35_20300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="178"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="280"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="552" mass="62141" checksum="AB4362BD4E732CF6" modified="2018-12-05" version="1">MNNVVASEWAESRFPLYTAERIHSLFSTSNLPEYKFNESLTVLIAIAGGEGILKADDQIYELMEGSVILLPAHSDAALIAKRPQPLHAYMLVIGTREQAMSAASGAMIRKSEAASNSTIQMFPHEPAIAAGLEELYIHRSPESEARHVQNQIVFHQIILQLLDRQESKYAASEQPSMERSIAYLENHYSEKITRERLAEIAGVSRSHYSILFKQLTGFTPNEYLSRLRVHRAKELLINGSGTLREIALKVGYKDEFYLSRRFKQQTGEPPSVYNRGSFERVAVWLTPYASHLLLLGLEPAVIISDNSEYVNAAGLQPPQTMIFINADSSVEQVKSVLLDNNVELIIAASQHLQQYGLNAGHMRAVAPIVEISWMEIGWKEHLRLIAQVIQRSERAEQWLADFEKEEQAARSLVQQSEAANEIITILVIKPEELLVYGARNVGYVVYQSLGLQPPAKIKREMEKLGDRLHSIPIEISELADYAGDRILAIVFPDVKGSTAHSEAIFSSSYWNELPAVRRNCVHYLDKDEWIPYNPVSIRLQLQRAAALFAGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL57</accession>
    <name>A0A398CL57_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_28475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00361">
        <property type="protein sequence ID" value="RIE00361"/>
        <property type="gene ID" value="D3H35_28475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017393386" evidence="2">
        <location>
            <begin position="25"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="160" mass="16563" checksum="FB115F6D43C13CD1" modified="2018-12-05" version="1">MRNMKFAALGLVLTLIIGILSACGGNDSPKSSGNASESPASSGASGSGETVELSMLFGASLFGGIHEDLIKEFESSHPNIKIKAESLPDSGIFDALRTRISSGDVPDMFHINIGHVTTTLADEAGYITDLSSFESIANYSSSIQAATKTKSGKTGLFTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLC3</accession>
    <name>A0A398CLC3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_25110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01698">
        <property type="protein sequence ID" value="RIE01698"/>
        <property type="gene ID" value="D3H35_25110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="42"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="248" mass="27726" checksum="24C34DE1C9CD7567" modified="2018-12-05" version="1">MLMTALQPATFLFEYPPKLIPSHMTLSNFVQAWTSQNFSVYLGNSVFVTMMSFIVIFFLSSMMAFAYSRYRFAFKGASFAILMGTLVIPSLTLIIPQFLLINQLRLFDSYWGLVTVYAASGIPFTTFMLKGFFDSISRDIDESVAIDGGSSFRLFISVILPLSKPAFVPVTIFNALTIWEEFPWALTIINNPLKRTLPIALANFQGQYTTQWGVVFAGAFIAVIPVILLFLIMQRYFISGITAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLI1</accession>
    <name>A0A398CLI1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_26270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00707">
        <property type="protein sequence ID" value="RIE00707"/>
        <property type="gene ID" value="D3H35_26270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="430"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="531" mass="59827" checksum="0E86B8D470F1605D" modified="2018-12-05" version="1">MYKALIIDDELPARRAIRALGEWDKHGIELAGEADNGITGLQMLDEHSPDLVFVDMKMPLLGGQAFLEQAKRKHPNACYVVISGFDDFDYARSAIQAGSIDYLLKPIRKAELSDVIDRAIALIDKLRDKDRKERKSDIYRNLSVPLVKEKIYSSIIDRNGRFHHISELQAVLDTDSATPCRVAVFKLLNVAEAVRLKFAGDSHAFYFAVTNAIDELLGRWGKAFSFKNSRGDQEIVAVIGSAMEDKDRDETISVLADSLARLFRVSVIAEIGLPVGMDELDESYAEATDKLLSRNMLDLQSVRATGEPSSDRPSVMDKSALFEQAIESGSYRQAGQLLRGWMEETEAAGTFTLRAMLAAENELRLLAESLLTAFLPNVQESIATLEEFDRKIRDRAFVFKDFKDTTLAYFETLFESLAGAGKAGELSAADKVKEYIDLHYFEDMPVSFFAGRFHTSKEHLTRIFKQKYGFGIHEYMLQVRMAKAKEWLADKTVKIQTVSEKVGYRDQNYFSKAFKKFTGQSPQEYRASVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLM1</accession>
    <name>A0A398CLM1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_06360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04236">
        <property type="protein sequence ID" value="RIE04236"/>
        <property type="gene ID" value="D3H35_06360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="93" mass="10944" checksum="B6F6B2C330137B83" modified="2018-12-05" version="1">MRLLDSLFYWLQMKLVSEARPDDGAARETVLFFAQILSDDHQLTSFQIESKDELKWYVSYSDKDGAVKTVWFDREAAEMLLHDMGVYTKEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLP7</accession>
    <name>A0A398CLP7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4291 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03180">
        <property type="protein sequence ID" value="RIE03180"/>
        <property type="gene ID" value="D3H35_17875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025633">
        <property type="entry name" value="DUF4291"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567">
        <property type="entry name" value="PTHR38567"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14124">
        <property type="entry name" value="DUF4291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="185" mass="21451" checksum="0ECF096192A10316" modified="2018-12-05" version="1">MSVKSKNKSTENKRIHAQYDEKSIRVYQAYNYKIADEAVSLGTFGSHFKLGRTTWIKPSFLWMMYRSGWATKENQERILAIDIRRTGFDIILENVVLSAFKAEVYGQYENWKTRLENSNVICQWDPCRDILGNPLDERAIQLGLKGDIVNNYVNDWIVNITDITNTVIELGEAIKSKTFKDSMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLR1</accession>
    <name>A0A398CLR1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01798">
        <property type="protein sequence ID" value="RIE01798"/>
        <property type="gene ID" value="D3H35_13445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="126" mass="14551" checksum="1AC44CB33C335FE6" modified="2018-12-05" version="1">MDRKKYNISVEATLEVIGGKWKCVILCYLTYGKKRTSDLKRLMPGITQKMLTQQLRELEQDGIVNRISYNQVPPKVEYELSEYGSSLRPILDSLCAWGENHIVKEYGDKSCMLEDNCLNNKAEKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLS7</accession>
    <name>A0A398CLS7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNTP triphosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dgt</name>
        <name evidence="2" type="ORF">D3H35_12020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03395">
        <property type="protein sequence ID" value="RIE03395"/>
        <property type="gene ID" value="D3H35_12020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006261">
        <property type="entry name" value="dNTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020779">
        <property type="entry name" value="dNTPase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF32">
        <property type="entry name" value="PTHR11373:SF32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01353">
        <property type="entry name" value="dGTP_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="57"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="438" mass="50970" checksum="38FB7F148DFEACE3" modified="2018-12-05" version="1">MNIRKMRLHDAVSLHASEDRDEYERDYARLIQSPAFRRLQGKSQVFGAGSGDYYRTRLTHSLEVSQIARELARRLGKTDPFLARKEHPGLMIEPEVVECSALAHDLGHPPFGHKGEEVLNELLQTEHALKYEGNAQNYRILMFLEKRAGSDLGLDLTAAVLLGINKYPYCIDEPGRIKGLYRMEWEAISQLRQTWGMPEGCATLEAQLMDLSDDIAYSTHDLEDGIRAGKIQMDRAFFEDDRLVEHVIHEIVSDQTNTGTSWEQVDMNAKVKQVLQVFYEQWATIYDECGREPSRTRREMKARWVRKFASQVGIIDDPAKSWKKVTFVREGQQDFDLLRTMEVLKKLAWVTLIKDFRVQRLHKRSEVMVGRLWTSFRDYETGRLIIPPDWLESYERHKGKWTWERLVADYISGMTDAYAEKVYAEFFASRSGSIYERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLV2</accession>
    <name>A0A398CLV2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_20475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03222">
        <property type="protein sequence ID" value="RIE03222"/>
        <property type="gene ID" value="D3H35_20475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="176"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="5">
        <location>
            <begin position="393"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="350"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="350"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="658" mass="75128" checksum="63F003BE42A5086E" modified="2018-12-05" version="1">MKLHEHIMIWNHVFIKVVDVRHTAMDKGEELRDYRLPGSGFLYAVRGNARIWMDCKPHRVDRFHLFHGGKGTSLTILADDVLEYYLILYKAILALPGRQELVKLMEEDNLFRYQYAFVPIYPLSLFDSVERLDKEWRKSAMLDHLQVKAIFFQFVHELLWQLRRQDIEPFKPDLVELATRYIHEHYDEPLTLDALAKALECSAGHLSRLFKSKIQSSPIHYLGQVRADRTVQLLMRTDATLQEIAERVGFPDAHSLSRSFKKYKGTSPGRYRKKNSMDRQDRDLPEFMQGIAVLQNKARPYNDIENHYQQITGRELFMQKRTKIAAMTVAMCVTLLLSACSGAANTNRNAQAEASQPTGTQSEQASKAPQAETPKQTRIVSTPKGDVEVPTEPKRVVADQYMGHLLKLGIVPIGVRTFMLTEGWMDKAGIEKETLAKIEDMGGFPMNLEKMVSMEPDLIIGSVEENYEQYDKVGTTVFLPYWEGKSTAGPLDKFRKVSDIFGKRQEAEKWIAEYEQKVTEAQEKLKGVIKDGETVSVVQFSEKAIYVLAAKGGNYGSATIYQMLKLPPTDAAANMEEGFKSISMEILPDYLGDYIFVYNGDVEATRKAMESDLWKGIPSVKKNHVYLYGNSFHDEFVMEDPYSLELQLDTIVNLLLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM00</accession>
    <name>A0A398CM00_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="6">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sucC</name>
        <name evidence="9" type="ORF">D3H35_11310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03272">
        <property type="protein sequence ID" value="RIE03272"/>
        <property type="gene ID" value="D3H35_11310"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="9"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding; shared with subunit alpha" evidence="6">
        <location>
            <begin position="321"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="53"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="386" mass="41252" checksum="9C30D74BAB0DC387" modified="2018-12-05" version="1">MNIHEYQGKEVLRQYGVSVPRGKVAFTAEEAVAAAQELGSAVTVVKAQIHAGGRGKAGGVKIAKSLDDVRNFANELIGKVLVTHQTGPEGKEVKRLLIEEGCDIKKEYYVGVVVDRATGRIVMMASEEGGTEIEEVAAHSPEKIIKEIVDPVTGLLPFQARRLAYAINIPNELVNKAAGFMLKLYKAFEDKDCSIAEINPLVVTGSGDVMALDAKLNFDSNALFRHKDIVALRDLDEEDEKEIQASKYDLSYIALDGNIGCMVNGAGLAMATMDIIKYYGGEPANFLDVGGGATKEKVTEAFKIILSDANVKGIFVNIFGGIMKCDVIAEGVVAAARELGLDKPLVVRLEGTNVKLGKEILNGSGLNIVAADSMADGAQKIVSLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM77</accession>
    <name>A0A398CM77_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_11815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03360">
        <property type="protein sequence ID" value="RIE03360"/>
        <property type="gene ID" value="D3H35_11815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="200" mass="21928" checksum="D9A856C2809ED6EB" modified="2018-12-05" version="1">MTTDRIDLVAASIPPNSLYLTLNFSGGQSALSLIPESPSIVLKHGTLKHTVSIAKLEDRECVADFLEINPLTAKKLGLTPNRRYEINYSAANRTLTLTSSPVSLANGVILSSPKLGMGTVSIGYELLARLGIPERRGFPLRLQLGSQKFNLRLFVPTNLDENRLTLSSYWAKKLQLVSGHSYSLRYDQRTSTIAIVARSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMG4</accession>
    <name>A0A398CMG4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_12450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03462">
        <property type="protein sequence ID" value="RIE03462"/>
        <property type="gene ID" value="D3H35_12450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017380101" evidence="2">
        <location>
            <begin position="26"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="106" mass="10863" checksum="433355E0B66A0C56" modified="2018-12-05" version="1">MMKRKWLLAFALFAVVASAGGAAYAATHTTNAGTTETTGAGAVQSQEKSDGDGETADDQEKSDGDGEVADDQEKSDGDGEVADDQEDNGAADDQEDNEADGETADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMG8</accession>
    <name>A0A398CMG8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_10165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03655">
        <property type="protein sequence ID" value="RIE03655"/>
        <property type="gene ID" value="D3H35_10165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901575">
        <property type="term" value="P:organic substance catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="5">
        <location>
            <begin position="149"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid" evidence="4">
        <location>
            <begin position="325"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="6">
        <location>
            <begin position="430"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="7">
        <location>
            <begin position="779"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="893" mass="100050" checksum="6CECCBAF3BC533D9" modified="2018-12-05" version="1">MPIQPIQLRTEYRDNPLGLDELEPRLFWRLAGKDRSERQSAYRILVSTSLEALAQNIGDCWDSGKTLSGESAHIVYAGAKLQAEGRYYWKVQAWDGEDRASDWSETAFWTMGLLSREAYKGSWIGRKKEPDADMQPSPFLRKAFSAKGKVARATAYATALGLYEFHVNGKKVGDLFAPGFTDYDKRVQVQAYDVTDLLTEGDNAVGAVLGDGWYCGTVGFLGNHVYGERPFFLLQLNLEYADGSKESVVTDASWRTARGPLQYSDMILGETYDAREELTGWDRPGYDDSEWETPDVRSGYNGLLVSMVEPPVRITQTMKPISVRRTEQGTYIYDMGQNMVGWTEVKVRGERGTKITLSHAEMLNPDGTLYLDNLRVAVQQEHYILKGEGEERYEPHFTFHGFRYVELVGYPGEPDLHTIAGKVVHSDTPRTGTLETNDAMVNKLYSNITWGQRGNFLSVPTDCPQRDERLGWTGDAQIFARTASYNMDVSQFFTKFMWDMIDSQQPSGAFTDVAPDAGWIRHKMWNTRLNWFAPDNAGWGDAGVVIPWTLYLMYGDTRILETHYGAMERWVEYLRQTTADLIRPDYANYGDWLSIGADTPNEVLATAYFAYSTKLFSQIAGVLGKLEDEAKYESLFQSIAEAFRKAFVGSDGRIKGETQTVYVLALQFGLLTEELRQLAIGHLTDDIARKGDRLSTGFLGVGYLLPALTDNGRLDVAYGLLTQEEFPSWMYSIKHGATTIWERWDGWTEHNGFQTPTMNSFNHYSLGSVGEWMFRYMGGIEADPARPGFRHAVVRPRPGGRVTSASASYESLYGTIVSEWEKRPDGSFRLRVVVPANATAAVDVPGVRATVDGVAVSGIGDSGDGWAYEGELYGESRFVVGSGEYVFETAPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMQ5</accession>
    <name>A0A398CMQ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00204">
        <property type="protein sequence ID" value="RIE00204"/>
        <property type="gene ID" value="D3H35_29645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="162" mass="19160" checksum="64E2CA7F4509576D" modified="2018-12-05" version="1">MQIVRMFSYREWSDSEDRVLRSIQEEAVPNEEIFLRKLVNATVIRNQLYEHTSNESEEGARHIVYAKPFNENDLELYGAHIKAPLFEQCVRSACIEAEFLYWTETTMFQRRDALAPERELIEISQLLLDHYLILGGRTCETVYSVFDTDMNKVILYLREVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMS3</accession>
    <name>A0A398CMS3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_09420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03765">
        <property type="protein sequence ID" value="RIE03765"/>
        <property type="gene ID" value="D3H35_09420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="1261"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="1320"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="1385"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1441" mass="157838" checksum="447325CB943507AD" modified="2018-12-05" version="1">MEPGKLNLTFLSNDENKSYHLSKSVNIQSDTVVSLTEQDIASANKIVFPSNTYSLGMYYYIDSVGTYREFSDTNELIVSKGTYSFYLYTKDSSNYYSWKSNKNNISNNKDYSVLNKPVLRLDTFEISDEGLNVEGSLVSGELSLLGVTDFYYNTISSQATLKDQGGNIVQEQQKIGRFWNSLTIPLDSPLQAGTYTLEFSVNYPGLAEPFQVNREVIVHSMDNNEIKGLVVEAEDESGEPLQNGHVMLFEKQLPNWSWFYSGYASNRTYDAGSIGDGKFFIPNAFLLAGKQYEVVVYGKSSDGMTDVFYNQPVSSGQANVKFTASSLKKLTFEASQAQAGQEVRVSLQNSDGLLVAWPFPVSFGADRKASMYIHTDNNLLVNSNLYDEAADTAYYLEKAYSLSSSATQTVNLAGPLVSITPPSGYDSAKLSINEGMPASKYYATQGISATVLYSLEKNGTSYTLSKLFSNLAKNERLSFDKNFSPRNSAQSFQNSANASVVNSDYYDNKDNYLYEVSSGPGSQFNGLNQTARFQVQTNEGSKKMLARRSGQDVVYQLVDNSTEGTLNLLEYQLYDGSTRAVGSKVYSNSLRSIQMNMPSVDGNYSLNLIKQNFPNDVVKLSGSIPISVVSNFKISISLPSGYELNPFGWNQSVEIWSKDGERENQYPAFIDIDGNLGILSFDSFQPNTEYEINFALSLRKIGSSFEEVSMYYNRIKLKGSQLKKLVRIAVPNDVVTIQPTYSSPVSSDALAQYNMAISGYEKAFSFYVEGEKADAGWEFPPVILSPRQFDVVVTGVDGVKAFSSLKTVNVSSDGRDVTVTDKPSYSVRLKDNSPFLNFYTFYEGTRSSGIAGYNYSDKLMLNQAFVSMGKQNLQFETVDIAPNETPWVNSWTTSVPKDVQSDTVIDFDGKINASASSLDVVILDDLIFKLKPNLISGDLKLQGVQVLLDRFVSPNFSQSAFAQNAEVQQTVAYEGSFSSPRQVPAVVSISDAAGKVVYESQTNQWQDGVYIFHKLAPGTYTFTFRVPVGPNEEAKVSKAFTVKSADNGTGGTGGTGGNGDGGVGGGEAIPGGTVDPATEPNNQVTEFKKDDIPAAANGTVTLDAKGKEEVVLPLSAVETIGTSRLQVRTANSEVAIPPQVLEQLSKLAAGKELEGAKISFKVQPVDLKAALPTDGNVSITGPVYEFQLSVSMADGTTRKLTQFDAPILLTFEVEPGAANRSITGVYYIDDNGKLEYVGGKWDGNRIVAEVRHFSKFGALTYDKRFSDVSDKHWAYNVIRQMVAKQIVTGVSEVSFAPERKITRAEFASMLANALQLKAERSAAFADVPSNAWYLGAISAAFEKGILRGVGNNRFAPNKEITREEMAVMVVNAIRLSERKESSGQNPTFKDSDEVSAWAQDAVNSAYRNGVMNGRGLNSFAPKQQATRAEAVQVIYNLLNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN20</accession>
    <name>A0A398CN20_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_15720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02188">
        <property type="protein sequence ID" value="RIE02188"/>
        <property type="gene ID" value="D3H35_15720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="7"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="318" mass="35475" checksum="498E820B93252771" modified="2018-12-05" version="1">MAEDIILEARDLKKHFNLGGGRILKAVDGLNFAIKRGETFGLVGESGCGKSTAGRTLIGLYDATEGDIAFNGRNVRQMDRDGKRKFNRSMQMVFQDPYASLNPRMTVGRIIAEGIDIHGLYSGKERDARVKQLLKDVGLNEEHAGRFPHEFSGGQRQRIGIARALAIEPEFIIADEPISALDVSVQAQVVNLFKKLQHDRGLTYLFIAHDLAMVKHISDRIGVMYLGKLVEVTTSEKLNSKPLHPYTRSLLSAIPLPDPKLQRERERIILQGEIPSPLNPPSGCPFRTRCPNAMAKCAESMPEFKEVEPDHYTACHLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CND0</accession>
    <name>A0A398CND0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF386 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_05220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04866">
        <property type="protein sequence ID" value="RIE04866"/>
        <property type="gene ID" value="D3H35_05220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004375">
        <property type="entry name" value="NanQ/TabA/YiaL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037012">
        <property type="entry name" value="NanQ/TabA/YiaL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34986">
        <property type="entry name" value="PTHR34986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04074">
        <property type="entry name" value="DUF386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00022">
        <property type="entry name" value="TIGR00022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="160" mass="18300" checksum="384C4144EDD3B0FF" modified="2018-12-05" version="1">MIFGDTGMTKTGEFGALHPVLRDALLRLERTDLKGMEPGKYEWDGDRLFLLVQESVTAPKTAKKPESHRRYVDIQLLIEGEEWIGYARKSVSHLSCEDELDAKDYALYEDPEDEIGLILRPGKFAIFFPDELHRPCVCLEAPVRIKKAVVKIDLILLEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNK4</accession>
    <name>A0A398CNK4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_19550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02829">
        <property type="protein sequence ID" value="RIE02829"/>
        <property type="gene ID" value="D3H35_19550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="199"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="484" mass="53923" checksum="02B13913887E189D" modified="2018-12-05" version="1">MGRSSQRDRSGASDSEEGTIIVENSEKIAIGSGVYMRPPHSLSVIGTGRGAEAPSIVIRDGCQCNLGLTIEAVNEVVLERHVLTGSNVYLSDAERPYPGSSPWANGHPDVSEGRLSIGEGAYIGTNSAVLGPVRIGRGSVVKPNSVVTKDVPDYCAACGNPAVITEVYVPETGKWEKAGNEEEAFRLLERRRLRPLLTIGIPTYNRAANLDYCLSTIFMQIGDSELVEVFVSDNASTDGTSEVIERYSRSFRNLEHSRNERNIGADRNILHVTNAANGKFIKLQGDDDFFVDGTILPLLNLLHRRGDCGVVHVNVLNGDGRISIGEGADDYLAATGYAATFITSTILRREDWQRVAEPSKFNDSSLNQFYFQYAVLTECNPKFAIMNCGMFTYAGNEPREYNFGEVFVRNYLAVLRSFEGRGLSEERIRADKAKLFYHYLMPWYRRIRTMYDREITAGFEEIFMADFRDEPYFDEALAWIRSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNT6</accession>
    <name>A0A398CNT6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">clpX</name>
        <name evidence="9" type="ORF">D3H35_07990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ClpX chaperone family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03900">
        <property type="protein sequence ID" value="RIE03900"/>
        <property type="gene ID" value="D3H35_07990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="117"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="418" mass="46254" checksum="85AC7E2A8150F495" modified="2018-12-05" version="1">MFKFNDEKGQLKCSFCGKSQDQVRKLVAGPGVYICDECIELCTEIVEEELGSEEELDLKDIPKPKDIRNILDQYVIGQEQAKKSLSVAVYNHYKRINSQSKIEDVELQKSNIMLVGPTGSGKTLLAQTMAKILNVPFAIADATSLTEAGYVGEDVENILLKLIQAADYDVEKAERGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPHQEFIQIDTTNILFICGGAFDGLEQLIKRRIGKKVIGFSAAIEGQKEMKAGEYLSLAQPEDLLKFGLIPEFVGRLPVISTLEPLDEAALVRILSEPKNALVKQYQKLLEMDNVKLEFDGGALEEIAREAIKRNTGARGLRAIIEGIMLDVMYEVPSREDVTNCLVTEKVVKEKMSPELTSKKGKKKEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNZ4</accession>
    <name>A0A398CNZ4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04235">
        <property type="protein sequence ID" value="RIE04235"/>
        <property type="gene ID" value="D3H35_06355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025620">
        <property type="entry name" value="YlaH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14036">
        <property type="entry name" value="YlaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="102" mass="11788" checksum="6899585C148031D5" modified="2018-12-05" version="1">MQQWFSDHPIVSYVLILAFTIYIFNAVFKMGKLPILKEIIVYIIMAIGCLVLLIFQIDKLPIIQCMSVAVAMMIMLRLRQLYDKRRNRGRASDAAEQPKAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP08</accession>
    <name>A0A398CP08_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_09165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04102">
        <property type="protein sequence ID" value="RIE04102"/>
        <property type="gene ID" value="D3H35_09165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="21"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="223"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="472" mass="53946" checksum="A1B48012A319EC2C" modified="2018-12-05" version="1">MAKRMRILLTCYFYLPSTAGLWPYVKELKQALEREGHEVDLLTHHPDVLKYYISNSGKFVMKYKVKYQVQEKVGPLYDQYFPGLDARVKDYEFERISFELAASCFDLWKYDLIHAQDVISARAMARIKPKQTPLIATLHGAFAHEQLLQEEIKSKDSIRWHYAMFRDHYGAIAADEIIVPSEWLKGMLIKENNVPSDNITVVPYGIHIDSFMERMEQTPLIGPPNNKRIIACPARLSVEKGHKYLLEALVKLKQERDDWVCWLMGDGVLRDELMQLTKECNLQHNVLFMGSQHNVPVLLKISDIFVLPSIQDNLPFAVMEAQLAGKPIVVTDAGGLPGMIEHNKTGLIAKAGSGESLYLNIKEALDNEALRESMGKNAREFGLSNWPIERMIAGLFAVYEETIKKGDKVRKATKRNQSSPLVSEQLSMIATPFDHHDGENLWKRLYPQLPSEYSILDSGFIRVLNEYKNYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP25</accession>
    <name>A0A398CP25_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polymer-forming cytoskeletal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02508">
        <property type="protein sequence ID" value="RIE02508"/>
        <property type="gene ID" value="D3H35_17615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007607">
        <property type="entry name" value="BacA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35024">
        <property type="entry name" value="PTHR35024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04519">
        <property type="entry name" value="Bactofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="162" mass="16851" checksum="35AA8F45D8060F7B" modified="2018-12-05" version="1">MFKSKKTKLDPNMTDTLIGEGTHFEGRLKSEASIRIEGHIVGDIDSQGDVTIGENGEARSNINARHVILAGQVTGNVQAAGKLTIKATGKLHGNLSAMELAIEPGGVFLGTSSKLAQETQPEGEAKLSSIDDPNAASASSAPSPAQTAAKLEESTATVLRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP46</accession>
    <name>A0A398CP46_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05156">
        <property type="protein sequence ID" value="RIE05156"/>
        <property type="gene ID" value="D3H35_01945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="572" mass="63390" checksum="8C83D16B4B3E4706" modified="2018-12-05" version="1">MAVPPLATAARRETYGKQGCSSKRQQAQNIVQGVMSMKRSSSVLMGLTAMALVVSACSNNNGDNASPSSSSKPSGTASSSPAEQKVKLNWFVTASADAQLPKGDADFVKKIIDEKFNVDLAIDYMPLGNDFTNKLNSLIASNDIPDVFFVDGITSNQYIKDGVAKEMTNVVTPATMPNYFKYWMKEEDLPKYQVQGKFARAPIPYEKNYYRSYYIRKDWLDTLGLQIPKSYDEMVEVMKAFTFNDPDGNKKNDTYGFTAYGNGTNMSMEFPTYVKNGLIGDFVIEGDKFIDTRTDLRMQKTLEDTKALLALKVVDPDWLLNKNGQQLEKAEQGKAGIVLGFGKNIAFDNNAEGLQAKTKEITGNANTNWVAFDPFAETGVFIEPVPGNPFLISSKASDAEVAKSTQILDWLSGEEGFLTTHYGREGTEYTRSGTQITLNQDAIKANVTDKGNFLSVYQWFTPISGPEAYGIDVMDPNITDRDKEIVNTMLSYKILPSVGTSLVIKEGMDLGALRKQMNALQVKIIYDEKDASNWPKYRQELMNKYGAKDIFTYYAEQVSAAQGKTITFDAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP91</accession>
    <name>A0A398CP91_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03129">
        <property type="protein sequence ID" value="RIE03129"/>
        <property type="gene ID" value="D3H35_14090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="102" mass="11692" checksum="C54B7269C2DFFC0E" modified="2018-12-05" version="1">MRTLYHPKTEEIELPTVLYALSDPIRLELLRHVLKCKEMACGEYATDIPKSTMSHHFKVLRESGVMNTRLAGTQRFMSVRKDELDSRFPGLLDAIVRASESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPH6</accession>
    <name>A0A398CPH6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01391">
        <property type="protein sequence ID" value="RIE01391"/>
        <property type="gene ID" value="D3H35_23775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="156" mass="17528" checksum="B7DC186D97842DB2" modified="2018-12-05" version="1">MNYKFVLIGLYIVFIYWLSSQEPALHALFYPTLGAFCFLFASRTFDARDVGRILIGATISSIIGSWLHQLYPSAISLFANVLIVAWLIKRFHWNAPPILAVSIVPFFVPQTNVWLIPASVSLSLLGLILVLACAHLIESKWREAPTLRRPIATEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPK5</accession>
    <name>A0A398CPK5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_09155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04100">
        <property type="protein sequence ID" value="RIE04100"/>
        <property type="gene ID" value="D3H35_09155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysacc_synt_2" evidence="2">
        <location>
            <begin position="7"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="326" mass="36092" checksum="79920B6FF1D41AA8" modified="2018-12-05" version="1">MFENKNILVTGGTGSLGFSLVRKLLGRKPNKVVVFSRNESAQFFMKNELQDHHLQFVRGDIRDKNSLLQVCKGIDYVFHLAALKHVSICEELPLEAHQSIVIGTQNVIDAAIANKVKKVIHMSTVKAANPNGVYGMSKSIGEKLIINANLEPSETRFIIVRGGNVLGASDSVAVQIKRQIASSEPIGITDLRMTRFFLTPQEASGLLVKSAIVGQGGETFVLNMRACKITDLAEVMKDKDGRSLRLVETGIRPGEKLHDILLTDDELQRAIVFSPELFVILPTIDAPGLQEFYSDNTPLFEGNFRSDNQEPMTKKEIRQMLAEGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPN5</accession>
    <name>A0A398CPN5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CRISPR type III-B/RAMP module-associated protein Cmr5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cmr5</name>
        <name evidence="6" type="ORF">D3H35_00900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISPR system Cmr5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05376">
        <property type="protein sequence ID" value="RIE05376"/>
        <property type="gene ID" value="D3H35_00900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023101">
        <property type="entry name" value="AF1862-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010160">
        <property type="entry name" value="CRISPR-assoc_prot_Cmr5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09701">
        <property type="entry name" value="Cas_Cmr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158568">
        <property type="entry name" value="SSF158568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01881">
        <property type="entry name" value="cas_Cmr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE05376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="132" mass="14787" checksum="029E17F3A844BE6E" modified="2018-12-05" version="1">MISSEKRYAQAAYSSMTDGFDPKDAAVFGTICHQFPSMVRLNGLRLTAIFYDAKASASDSSVRSKAYSRYCKYMEQALELQGVRLSEFVNSPACDSIRYRLLSRQALAASIWFKRYAEAILKVDAEAQEVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPQ0</accession>
    <name>A0A398CPQ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03269">
        <property type="protein sequence ID" value="RIE03269"/>
        <property type="gene ID" value="D3H35_11285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="625" mass="65994" checksum="392CD63A16B665AC" modified="2018-12-05" version="1">MSMNIGPMLRALLSEGQPAEGSKALELRIGQIVRGVLLELLDNQEAIVSINGVNVRARLDADMPVGRGTLLQVQTSSGGGLVALKPLADLSEMMPEEGLKDVLKSFSLPEQKWAMELVRGLKKDGYPISRDTASFFASAASLKPATTDSQSWMAASDVAFRRGLAPTEATIGSLRQALFGAPLHESIANVQTELAAWQSSGNAASSEASELGKKLQTLLARGAEYMVRAEAGKEGQPTFGDEAKKSVESSRPQPDGIARNADSARANPRGSAVNVADLSVQENVKAAIQARTDNEGDPIERSAPRSGLAEAGGERASAMPRATTSTSSQENAAAANRQASLSSSERSASGEAASGKTGNSAAEGSRPDGRQPTAAAPRQEGAWIGRFLQWIGAGHERNALHASDQRLGGDLTFPASAGTDLDATAEQASNQHGDSMKSALLALSSRDDIPPALRDAAQTLVNQITGQQLLLASERNGTSPFSHMTLFVPMKTADGETTATVHVQTRRGRRGEWDADNCRLLFDLRMRNLGDTVVDVQVVDRIVSLKLMNDFPGMQDLLEQARNELSSGIREAGFQLLSLTVSPLPSLRSGIEGADGAAGTDNPRGDYPPSSAFASKPYKGVDFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPQ9</accession>
    <name>A0A398CPQ9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTP-sensing transcriptional pleiotropic repressor CodY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">codY</name>
        <name evidence="10" type="ORF">D3H35_11345</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CodY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03279">
        <property type="protein sequence ID" value="RIE03279"/>
        <property type="gene ID" value="D3H35_11345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00621">
        <property type="entry name" value="HTH_type_CodY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014154">
        <property type="entry name" value="CodY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010312">
        <property type="entry name" value="GTP_sensing_CodY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013198">
        <property type="entry name" value="GTP_sensing_HTH_CodY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40062">
        <property type="entry name" value="PTHR40062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06018">
        <property type="entry name" value="CodY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08222">
        <property type="entry name" value="HTH_CodY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011572">
        <property type="entry name" value="GTP_sensing_CodY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02787">
        <property type="entry name" value="codY_Gpos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CodY" evidence="8">
        <location>
            <begin position="2"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_CodY" evidence="9">
        <location>
            <begin position="195"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="7">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="255" mass="28300" checksum="EE8A0A563C2E65F6" modified="2018-12-05" version="1">MTLLSKTRTLNKLLQRAAGKPLIFREMAEVLRETATADVFVVSRKGKILGSALSTHFPEMWLRQEHPDELRFPAETNENLLRIGETVTDVSKSETLSPVEAAFEGRTVTIVPIIGGGDRLGTIILSMDERIFGDDDLILAEYGSTLIGMEILRERAEEREVAARNKAVVSVAVNSLSFSEMEAIEQIFDELEGKEGLLVASKIADRAGITRSVIVNALRKLESAGVIETRSLGMKGTYIRILNFQLLQELENRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPV3</accession>
    <name>A0A398CPV3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000004">
        <property type="protein sequence ID" value="RIE05446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05446">
        <property type="protein sequence ID" value="RIE05446"/>
        <property type="gene ID" value="D3H35_00300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="62" mass="7107" checksum="DD038A9F7DFC04D1" modified="2018-12-05" version="1">MHLLAEESSRFNERLAVYETTRLYGETGKYRILQFADAAVQGAADLKNPSRIVLPYQRLSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ28</accession>
    <name>A0A398CQ28_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02858">
        <property type="protein sequence ID" value="RIE02858"/>
        <property type="gene ID" value="D3H35_19720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="63"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="156" mass="17721" checksum="5EE08169E929B1C8" modified="2018-12-05" version="1">MGESSGGRASVFSWGAIRYNGEKPEACPKKRRETNVEDQLQEFCEESCFASEEELGEVKKAMIDSAAADQLAELFKALGDPTRVKLIGALLHKELCVHDLTVLLDMNQSAVSHQLRYLRNLRMVKRRKSGKSVFYSLDDSHIEQIFVQTLQHLRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ29</accession>
    <name>A0A398CQ29_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01947">
        <property type="protein sequence ID" value="RIE01947"/>
        <property type="gene ID" value="D3H35_14335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="60" mass="6737" checksum="C1893417F9BB8EE8" modified="2018-12-05" version="1">MSVRAKSDALLDCPLISKKSFPALGHSFRCDIRVEQFVVHIIPFRFDPEISTLDSGNFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQC8</accession>
    <name>A0A398CQC8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02988">
        <property type="protein sequence ID" value="RIE02988"/>
        <property type="gene ID" value="D3H35_20515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="66"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="255" mass="27903" checksum="D70A8635B2C62CC5" modified="2018-12-05" version="1">MKASDNLLSQVRPKTRGSILWLTGWSMPDTVLDELRRWLPDFQHVSAAYSSAECPESMLLLTEKAARSVMDSEMRDGPMLIAGWSLGGLLALRLAAQGLADGLVLFGATARFTRSGEESNRGWADAYVRRMISGVTKDRQTVETSFRKLVLTEDEWASGLGRRLPPAGGWSASALVAGLQLLRTESVLPMLPAIDCPVLLVHGTEDRICPYGAALELMAALPGAKLVSISACGHAPFLGKEIFIADELRRWWHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQI3</accession>
    <name>A0A398CQI3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04805">
        <property type="protein sequence ID" value="RIE04805"/>
        <property type="gene ID" value="D3H35_04875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="96" mass="10599" checksum="927AA6CF723B8B9E" modified="2018-12-05" version="1">MPYALKRSDTGQLLASRQVNGYGLPYYGIVLWEEAPTSLRITESLAFAGLTPDDPIGSLSGWETVELTEHQAKMANVKLRNDPLRTVKMLDGTVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQY2</accession>
    <name>A0A398CQY2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_03240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04965">
        <property type="protein sequence ID" value="RIE04965"/>
        <property type="gene ID" value="D3H35_03240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006326">
        <property type="entry name" value="UDPGT_MGT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01426">
        <property type="entry name" value="MGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="480" mass="54703" checksum="32073A89900B2A2E" modified="2018-12-05" version="1">MFARDFTLRRNERGACRRNTGIMVEKINRIISCVETNRHIGFSAPIAWVNSQPLNERSHLNMNIVFFSFPYTGHINPTLGLVAELTSRGHKVEYYAINQFKGEIENTGANYREYPVGIIDEDVTVNEERRGKDPQNPFSGFAKKVLHQLDMTEMMTAELLIESASLKPDCIIHDSFCGWGKRIAKLLNVPAVSSITTFAFDDEIINLDPENVAKSLFAMTLENFNKTSMKRQLDRFRTTIEKKYKLDQFRLFDVFINREPLNIVYTSELFQIHSELFDNTFKFVGPSFDFRTENSVFPFETLAGKKNIFISLGTISGDDVGFWKACFHAFCNSDMQVIISSGNQTNLSLRSEDVPDNFIVKDYVPQIELLKHIDIFITHGGFNSVNEGLFHHLPLLVFPLKVDQFLVANQVERLGAGINLKNSSSNESVNYLELQLAVERLFHDKTYRMKSRIIGESMKSAGGAKRAADEIIQYIEGLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR97</accession>
    <name>A0A398CR97_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurS</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit III</fullName>
            <shortName evidence="5">FGAR amidotransferase III</shortName>
            <shortName evidence="5">FGAR-AT III</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">purS</name>
        <name evidence="6" type="ORF">D3H35_16655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PurS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02347">
        <property type="protein sequence ID" value="RIE02347"/>
        <property type="gene ID" value="D3H35_16655"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01926">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003850">
        <property type="entry name" value="PurS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34696">
        <property type="entry name" value="PTHR34696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02700">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="SSF82697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00302">
        <property type="entry name" value="TIGR00302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="80" mass="8997" checksum="18F534B7A3E3CEEB" modified="2018-12-05" version="1">MKAKVYVTIKQNVLDPQGNAVQGALHTMGFDEVGKVRIGKYLEIDLGTNDRAHAEERLAAMCEKLLANTVVEDYRYELED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRB4</accession>
    <name>A0A398CRB4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_14465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01971">
        <property type="protein sequence ID" value="RIE01971"/>
        <property type="gene ID" value="D3H35_14465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017418349" evidence="2">
        <location>
            <begin position="30"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="297" mass="32323" checksum="4AC2E8A1EA08BA44" modified="2018-12-05" version="1">MFSLLYRARYLALAVIIFCAACSSSKGEASSSAASPSATSSAQQSSADEWLTKAEDAAKQLKKYGFELNLNQKMSGESAGSNSTVKLDMQGRAELGPLKLDQTNKSDIDGEKSSLRAILVPDAYYMYSDEFKEWSKLSKEETANVVRTLSSLQINLAESIEGVRGLGSALAVKPSGDEIAISYNGNGPEALTFLESVLESTLDLSSMEPSVRDTIKIDSLEVLVKLDAQHHWPLSYRIDSVLTVEYEPGKPSTLEQSLEAFYSNHNATEPVVVPEEAKNAPELDPSLEDDFEFGDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRI6</accession>
    <name>A0A398CRI6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RraA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05152">
        <property type="protein sequence ID" value="RIE05152"/>
        <property type="gene ID" value="D3H35_01920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="SSF89562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="218" mass="23975" checksum="D9BF66A2DBBE1774" modified="2018-12-05" version="1">MNDKELFDRMTESLYAAVISDTLDELGHRNQVMRENINPIDPNWVLAGRAKTILSVDVHYIPDQPYAKEIEAVDSVKPEDVVIGCTNESKQNGLWGELLSTASKVRGARGAIVDGLIRDTAKIVELGFPVFATGTKPVDSQGRGIVIDYDVPVLCGGVRVNPGDVVFGDRDGIVVIPKDLVGEVFERALDKATRENHTRDELLAGRTLRQVYDKYGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRR4</accession>
    <name>A0A398CRR4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_25105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01624">
        <property type="protein sequence ID" value="RIE01624"/>
        <property type="gene ID" value="D3H35_25105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="68"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="289" mass="33039" checksum="33EF873B55068F95" modified="2018-12-05" version="1">MGRLNKRDGYYFVLPGFLFFSLFLVYPLCRNFFYSFYDFKLSNLSAKHFVGFDNYSRVFHDPVFGVSLKNILIYGVISVPGQMLLGFAVAFALNNSSAVTKIFRTLYFLPVITSWVVASLVFKFIFIDQGLLNYVISDVFHWTNAPISWLSEPKKAIGVLSLLGIWKGVGWTMVMYLAALQNVPKELYESAELDGCNVWKKIIHITLPSIQKTTLFVQIMLIIGAFNVFTSVFLITKGGPIHQTEVMLSWMYQKAFSDYDLGYASALSYMFAVIIAMFTWIQFKVSNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRX8</accession>
    <name>A0A398CRX8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_23715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01684">
        <property type="protein sequence ID" value="RIE01684"/>
        <property type="gene ID" value="D3H35_23715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="64"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="255" mass="28431" checksum="1A8DFEC8F5972718" modified="2018-12-05" version="1">MQIFEDISRKGFGMTAAFSFLLLLAGWSVLSYGEFVNPIFLPTPDRVLATFFDLLGTSAYWHHIGISIFRVSAGFVLACVIAIPIGLLAGTYRYGEAFVEPPMEFIRYMPAVAFIPLIMVWAGIGEWAKILLIFIGCFFQLTLMVAADTRLVSKDLVQASFTLGASRWQAIQTVVIPAVQPRLLNTLRLMLGWAWTYLVVAELVAVNSGLGYAIMKAQRFLNTDQIFVGIIVIGLLGLVSDRIFAFLNRRFFPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS35</accession>
    <name>A0A398CS35_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LTA synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_15680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the LTA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02181">
        <property type="protein sequence ID" value="RIE02181"/>
        <property type="gene ID" value="D3H35_15680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012160">
        <property type="entry name" value="LtaS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005091">
        <property type="entry name" value="Mmb_sulf_HI1246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="9">
        <location>
            <begin position="249"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE02181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="630" mass="70925" checksum="B0D999A596300E23" modified="2018-12-05" version="1">MRLRIIGSWFSKPFVFFTLIMILKMGLAQIVIFDAGSLWKTMIAGIPSVWVAFGLIELLFPRRKLGAYLIADLLMTCIYFAVIMYYKYFGVIVTFHALQQVGQVTEVKGSVFSLLHPYFLLIYIDIVVFWILLAARKSVRTWGKRLAVRESAKYASVLLVCSLIASVSTVWTHRDSVNELRQAEGMGILNYEIHTLVSSVFSGGITTAFANGSNEAVDPETITPEKIANLKQSVSSASSRDFGVAKGDNLIIVQLEAFQNFLLDLKLDGQEVTPNLNKLMRENKYFPRFYQQVGQGNTSDAEYVVNTSLLIPQYGAASQDYGDLALPSMPKTLAEHGYKTATFHTNDVEFWNRKELYKALGFQHYYDKSYFGDKDFVGFGSSDEVLYAKTTDKLLEMRAEGKPFYAQLISMSAHHPFNMVPSEKLSFKLPERYQGTMVGDYIQAQHYADYALGQFVEKLKISGLWDESILVVYGDHMGLPIYSLNSRERDLMYEIYDRPYNFTEMLNIPLIMAVPGETEPEKLTVTGGQSDIFPTVANLLGISLDNHIHFGQDLLNSTSNVLPQRYYLPTGSFINGNGIFVPGDGFADGTNYTFQGEAPKAAMATKEEYDRALELLRLSDSYVSHLPKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS40</accession>
    <name>A0A398CS40_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">secY</name>
        <name evidence="13" type="ORF">D3H35_02340</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 12">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05010">
        <property type="protein sequence ID" value="RIE05010"/>
        <property type="gene ID" value="D3H35_02340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE05010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="432" mass="47998" checksum="BAD8E016AC58F33F" modified="2018-12-05" version="1">MFRTVTNIWKVEDLRKRILFTLFILLVYRIGAFIPVPNINKDALEAANQQGSDLFGLLNTFSGGALFKFSIFALGIMPYITASIIVQLLSMDVIPKFTEWQKEGENGKRKLAQVTRYGTVILGLIQAFATAIGFNRLYNQEMVIDPTFATYTMIAIVLTAGTSFLMWLGEQINEKGIGNGISVLIFAGIVASFPTHAREIYATEFIDADQIFFNVLKVVAILVVIILIIAAVIFVQQGVRKIPVQYAKRVVGQKMYGGQSTHIPLKVNGAGVIPVIFASSLLMFPVTIANFWSTQAWADWVIKNMYYTQPLGMVLYVLLIVGFTFFYTFVQFNPQQMADNMKKNGGYIPGIRPGKPTQGYLMKLITRITLSGAIFLALISVLPVFFGKIAGLPQTVQLGGTSLLIVIGVALETMKQIESQLIKRHYKGFINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS75</accession>
    <name>A0A398CS75_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome C oxidase subunit IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_15970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase bacterial subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02231">
        <property type="protein sequence ID" value="RIE02231"/>
        <property type="gene ID" value="D3H35_15970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005171">
        <property type="entry name" value="Cyt_c_oxidase_su4_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03626">
        <property type="entry name" value="COX4_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="105" mass="11815" checksum="63D62E9E82CCA374" modified="2018-12-05" version="1">MASNHSAQESGAKRHRVEGPQKHVVGFIMSLALTIIAFAAVSAGDINTTFTYIILISMAVLQVFIQMAFWMHMKDRGHLFPIIGILSGVFVVFTMVIMALYWVWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSE1</accession>
    <name>A0A398CSE1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-dihydroxy-6-naphtoate synthase</fullName>
            <ecNumber evidence="3">4.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Menaquinone biosynthetic enzyme MqnD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mqnD</name>
        <name evidence="5" type="ORF">D3H35_03535</name>
        <name evidence="6" type="ORF">D3H35_03560</name>
        <name evidence="4" type="ORF">D3H35_13845</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MqnA/MqnD family. MqnD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000022">
        <property type="protein sequence ID" value="RIE04911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000022">
        <property type="protein sequence ID" value="RIE04915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01864">
        <property type="protein sequence ID" value="RIE01864"/>
        <property type="gene ID" value="D3H35_13845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04911">
        <property type="protein sequence ID" value="RIE04911"/>
        <property type="gene ID" value="D3H35_03535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04915">
        <property type="protein sequence ID" value="RIE04915"/>
        <property type="gene ID" value="D3H35_03560"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00996">
        <property type="entry name" value="MqnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003773">
        <property type="entry name" value="Menaquinone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030869">
        <property type="entry name" value="MqnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37167">
        <property type="entry name" value="PTHR37167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02621">
        <property type="entry name" value="VitK2_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="53"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="111"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="279" mass="29719" checksum="3AF569A20E7AA149" modified="2018-12-05" version="1">MNIAFSPCPNDTFVFHAWVHGLIPGAPKLDVQYADIDITNGLSAGGEGPEVLKISYAALPWVLSDYRLIPCGGALGRGCGPLVLTAGGVDLSANPAALAGRRVAVPSERSTAYLLFRLWAAQNVPGGLGEIVVLPFHEIMPAVRDGRIDAGLVIHEARFTYPNYGLTLLTDLGSWWEADTGLPIPLGAIVARRSLDAEAIAEWARASVEYAWAHPEASRDYVMKHAQEMDPEVAKAHISLYVNEFTASLGEDGYAAVTALLGRAAAEGLVPVIDPALLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTT0</accession>
    <name>A0A398CTT0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04118">
        <property type="protein sequence ID" value="RIE04118"/>
        <property type="gene ID" value="D3H35_09255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="74" mass="8995" checksum="56625EE083F3A020" modified="2018-12-05" version="1">MADRTKAVTTAYFVTKFDLLKSEAGMNLSRLLERLRRIARTLSRKKSKRRYSNYNYEKYLRERLDRLQSNFSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU01</accession>
    <name>A0A398CU01_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aspartokinase</fullName>
            <ecNumber evidence="14">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">D3H35_11670</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 15">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 15">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 14">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="14"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03337">
        <property type="protein sequence ID" value="RIE03337"/>
        <property type="gene ID" value="D3H35_11670"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00656">
        <property type="entry name" value="asp_kin_monofn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 14 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="16">
        <location>
            <begin position="343"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="214"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RIE03337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="405" mass="42404" checksum="716D0EDFF8CE97FC" modified="2018-12-05" version="1">MVVTVQKFGGTSLSDEKSRRHVLRHIIREYEAGDGLVVVVSAMGRRGDPYATDTLLDLIRSNGNALAPRERDMLLSCGELISAATLCSLLHSQGIPAVALTGGQAGIVTDSRFGSARIIRIHTDTLLQHLEERRVAVVTGFQGMSENGETTTLGRGGSDTSATALGAALQAKIVDIYTDVDGILTADPRLVGDARPLPIVSYDEICNMAYNGAKVIHPRAVEIAMKAGVPVRVRSTFSDGEGTLVTHAEAVRGSSGWTDRTVTGLAHVCGVTQLSVSGEAPFDLQLSVFKAMAGSGISVDFISVMPASVHYTVSAADSNKAIALLKNLGFEPKVTTGCAKVSVIGGGMNGEPGVMAKIVEALTTNGITILQSADSNTTISILVTETQMAAALQALHTEFALHLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUB9</accession>
    <name>A0A398CUB9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_05185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04859">
        <property type="protein sequence ID" value="RIE04859"/>
        <property type="gene ID" value="D3H35_05185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="434"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="533" mass="60875" checksum="87089D5A62B8A86E" modified="2018-12-05" version="1">MKIMVIDDEPIVSVGLRKLVPWEEHGFEWLGAAENGMEALRMIESKPPDLIIVDCRMPIMDGLQLLREIGSRQIPIKSVILSSHDEFMYAQQALQLGASDYLLKPPDLDRFLEVILRVKKEWETERALKQQMKDNFPVMVERFLHSIVDGTRQKEDIFVEKTKYLRLPIHPGPFRVCLLEIEDETGSLDRYSVEDHHLIHFAVANIIEETFGEWHAKALLQEQSRRFILLLNDEDGDAEQPTTLRSLLKQLIVNLRTTLKLGATVGVSKRYPLLLNDCRSAYENAKTALRYKYYTGANQAICMDDLDSGPGPTDAGSQNRSAVNEEDLLMSLRVCNENDLDAWLSSFIAFLKSRSFNQHETKTLSLQQMIASTHVLAEMHPQLQLDELLSADDIARIFRANTIEELSGLLREFLYGLLATTQSLRKSGKNSVVEKIKAYIQDNYARNLTLETIAAEVFLSPVYLSFLFKQVEAMNITDFITQVRIDRAKALLLTTNSKTYEIAGLVGYQDDKYFARIFKKRVGMTPSEFRSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV62</accession>
    <name>A0A398CV62_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_09495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03777">
        <property type="protein sequence ID" value="RIE03777"/>
        <property type="gene ID" value="D3H35_09495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017334145" evidence="1">
        <location>
            <begin position="24"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="3">
        <location>
            <begin position="1084"/>
            <end position="1221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1561" mass="168082" checksum="D6E9F02C97F8B792" modified="2018-12-05" version="1">MSTGNLALNKPITATSGTHPANAANDGNAQTYYESVYTLPQSLTVDLVYAYSVNRLILKMPSNFPDRTLTLTVQGSTDNSTFFDIVASASYPFLVASGNIVTVTLPATSARYVRLYFTGNTSRTSAQLGELEVYADSNAADLIATDITWSPSNPKEGDAVTFSAVVKNIGLSATPEGVGHTAAFKIDGTTVASTAPYSASIAPGGTATLTATSAWTAIRYKFDIQAIVNSTGTVGESNALNNDDYFKSLTVAGSGWQSSFNIKESLGIYEFPEETIGYPLTFAGYNVTPDHIRLRQYGQSSPLVYQLANVSLNGSGFLTGATIYFRTGLNFGVLKRYTVDWDSSYSPSFDNPVTFSDNGDGTATIAGNEQQIKVPYGNVNLNGAALSSVPAPLLALSRQPGSWIGSGSFSAPAGINVSSLNGRVTEQGPLFIKYTVTYTINNGRIYNAEMTVRHGEKYVTVDETYEGFLSSHSAFLRFSYKNGVDPDGRIVMQNGGYIRTTSGGRSGLYGEGADSSGKLPYELGIYAVNSNNLARSTSFWKDSGSEAILFATYRLKDWKTETRQIYNAYIKQNLRFYSNATDKYMEASIEGTERHWALSVIPRSQEVLSGRRMSDMVKPPDALIDTAWTNIPTSVGQQPGTAPDVKLWQKLADFSLDGYKDMVFDFPEDASRTLPIPGYNNVPIADPNDYWTDKYSFSPFRKFYNLTDKYWDVSSDLGPTGNFGRAARYLFSDYAYNRGNWGYDERKRTRSLLVFMGYLAAGDNNLPHTSMLSGHPNFNLDVKQTIALAAGAFPEHPHAASWKAAFLQDYDECFAAYMRQFNASQRTEAGRWYENLPTYANASLMPMMAAQASLISYDQTDIFAHPGFKTLLRWVMNSLSPNERASFRTPVPVGAHASGGDPGGEFDGIYRLLADRAALSDPLLGSQMLWSATNGAQGVNPQLQSTVYTDFGPVLRYDFGGPNEAFLYLQQLTGPGYRWSPSTNGAVYYAAKGKRYSWSGGEDSGDYIDLNKLPLFQLNGKSLGDHKADGILYNFGEVQYYNAAANGSSAPYLSRGILMVRGDYIGIYDDLSGAAANGAFQWTNRETGLKARYYNNTDFTDLRSTRIDNSRFPGTGSWGPGLPDPALSPDTYSIAWTGLVWPKFSESYTFSATVGAGDSAKIYVNGTLAVDTAAGTSTPIAMSTNQFYEIRIEYVHYTGSSSIQWKWSSASQGLTNVDGLLHLSWALDQTPMIYTVKDGPGDEFHLVAPEAISVSNQIYGAIVANNEYVFASDTVQNVSSGSVVFNGRIGYAEAQRIALFDGTAIGYGDLVLERAGGDFGASAEAVAPDRIEGRIAGRSGGTLTVTLPAAFTAQTVAVTVGGNPVPSTKSGNKVAFNVSIAQSDGVKAYAIEPGTATEPLFSDSFEDGDANGWTVTAGTWNVAPASPEKVYATTGGAVTAGNAAWSSYLVKAKVKLAGSATADLMGRYSNGNNFYYLQLDGGANRLKLYKKAGGAVALLSSVAFAVTPGQWYELQLGMSGASLSGAVDGNNLISVTDGSLTAGKIGLRSSGEATFDDIVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVA5</accession>
    <name>A0A398CVA5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_18870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03191">
        <property type="protein sequence ID" value="RIE03191"/>
        <property type="gene ID" value="D3H35_18870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005690">
        <property type="entry name" value="GerBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="482" mass="52873" checksum="95DDF97779626920" modified="2018-12-05" version="1">MSELRNVFVDCSDIVFHSFSMKDGTECGVVSVKGLSDTQALERQVIAPLLVMEWEGNDKSARRLFSRLPASSCQEYEKIGELADRLCVGYPVVLVDGASTAYSFDMIGPEQRSVEEPVAESTVRGPRDGFTESLGVNLPLIRKRLKTPDLKVAGMTVGSYSRTEVAVVYIKGIADPALAGEIKRRIEGMRIEGLLESESIEEWISDNPVSPFPQLLSTERPDVVCANLLEGRIAILIDGTPFALVAPVSLFSMLQSPEDYYQNILSSSFIRWLRYVFFVMSLLLPSAYVAITTYHQEMIPTVLLLNIAKSREEIPFPALVEALIMEITFEALREAGVRLPKQVGAAVSIVGALVIGQAATSAGIVSAPMVIVVAITGISSFMIPRYSLGIPPRILRFPIMILAGTLGLVGVMLGFILIVVHLSKLRSFGLPYLSPVTPTRFRELKDVFLRSPIWTTDTKPALSGSRLNSRTTSQTKGIRDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVU7</accession>
    <name>A0A398CVU7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Potassium-transporting ATPase subunit F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03144">
        <property type="protein sequence ID" value="RIE03144"/>
        <property type="gene ID" value="D3H35_15585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043462">
        <property type="term" value="P:regulation of ATP-dependent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011726">
        <property type="entry name" value="KdpF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09604">
        <property type="entry name" value="Potass_KdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="25" mass="2910" checksum="3002F02DA12108E6" modified="2018-12-05" version="1">MIVVSVFAGLLFLYLIYALVYPEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVX4</accession>
    <name>A0A398CVX4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Efflux RND transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000002">
        <property type="protein sequence ID" value="RIE05469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05469">
        <property type="protein sequence ID" value="RIE05469"/>
        <property type="gene ID" value="D3H35_00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="71" mass="7993" checksum="2962B60859FF2C50" modified="2018-12-05" version="1">MNDVKTPDGVKLNVGGASADQSEDFMSLFMMMLVSIGIVYLIMVITFKTLKARSPFCLPCCSYRLEPYWDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWT3</accession>
    <name>A0A398CWT3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">M6 family metalloprotease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_12530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03474">
        <property type="protein sequence ID" value="RIE03474"/>
        <property type="gene ID" value="D3H35_12530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005085">
        <property type="entry name" value="CBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03423">
        <property type="entry name" value="CBM_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05547">
        <property type="entry name" value="Peptidase_M6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017316980" evidence="1">
        <location>
            <begin position="28"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="534"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="785" mass="84937" checksum="3CEC276DD8AD0BD7" modified="2018-12-05" version="1">MKRLYKVLGVSSFLLLLGLCMGSLASAAPARTDLQTFTQPSGVQFQARLQGDEFLNWAATPSGEILVRDSNNYWNYAELEENRPTASGRKFGMDTKPSSAINKADMEQLFDEHPEEFKAPALDSSVKIDNNAGSQNNGPSLQQSVSATGNQKILVLLVEFSNIGMQYSESEWSNTFFGTTGKTVRNYYNEISNGRLTFLPATESSGTADDGVIKVALNYAHAAKIDFNQGNAIVHDALVAADPYINFASYDTNGNGAISNDELHIVTILAGYEESYGDTNLTAWGVTWSLSDENSATLDGKIICNEFKGGKYTQQGERHGNHRATIGILVHELGHMLGLPDLYDYDSSSTGVGQHSLMAFGSWASLTGEYIGTTPTHMDAWSKVQLGFVDPLIAKPASNTPYTLKSISTGGYNVVKLPTSVPEQYFLIENRQKEGYDASLTVNGGIAIWQIDDTQPVNSDDNRRLVDLKFFNSNNPYYYVGNVTDFGPTTTPNSNRYAMGNGYDKRNTGIQLSVASSSSSNMVVNVSGTYDNTPPMAPVGMTTLYTTASSVGFSWDPSTSTDTDYYKVYSNGNFIIDTDSTQFKGLYLQANSTYTYSVKSVDRSGNISAVGTAHTATTSNEDNIIIYYKRGFAAPNISYSRIYGDEIWHYESMQQAEIAGYNKIIIPVSGLNGSIIAGKIQNGSGEWDDANGRGYFFEPGVNVIANGFVSSDLPNGADAQAPAAPTNLATTGKTDTTVSLSWTASTDNVGVTGYDIYQGTAKVGTTASASYNVTGLSRAQRIRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX73</accession>
    <name>A0A398CX73_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_09670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyltransferase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03811">
        <property type="protein sequence ID" value="RIE03811"/>
        <property type="gene ID" value="D3H35_09670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="6"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="392" mass="44030" checksum="B0256191ACCA3B44" modified="2018-12-05" version="1">MERLDQLDSMRGLAAATVLIGHCLGVYSVFWVDTYGQAQYGLVNLLKFTPLSIVIAGHEAVVFFFVLSGFVLMLPFLSAKPFSYGTFVARRFLRIYLPYYGAILLALLIRSLLAQPDTNVYSEWIGLQWQSSLTWELLVQHLFLIGDFDSNSLNPVIWSLVHEMRISLVFPLLALIALRWNWKAAVALVPALSLLGYVFVYLSFHSPPRIESVFQALDSMQYVSFFLAGALLAKYRTNAVRWWKRKSLLFKAALVGLGWVAYTYAYTVLPGQSAIHKSFMNEFATMLGALIAILAAIGSARSRKLLLWQPIRRLGQMSYSLYLYHFIILMALLWIVPHSIPLPLVLAAIVVLSLAAAYASYRWVELPSIRWGKSLFAKTGKPGGMASLEKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXD5</accession>
    <name>A0A398CXD5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_07890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03881">
        <property type="protein sequence ID" value="RIE03881"/>
        <property type="gene ID" value="D3H35_07890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="AMP-binding" evidence="3">
        <location>
            <begin position="73"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="536"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="596" mass="65773" checksum="5FDFE6690F02B0C6" modified="2018-12-05" version="1">MKSRERVFRELLERLTKSPLYIEKLGNRNVTRLSLAQIGLLPLTRKEELRRAGSFGHLAVDMREVAQYHESFGTTGEPSASWFTSKDLKTGGKQMRECGVGLNPDDLVLIRFPYAMSLPAFLMQHAARQAGAGVVPASGRTPVTPYPRVLELMRRLGVTIVAGLPREMELLAETARLLGSDIKKDYPDLRALCVAGELTGELRRQHIERLWGVPVFNLYGSTETGNIAAMCEHGIMHIVEKDFVVETLAEDGFAPVDPGAKGFAAITTLTHEASPLLRYFNEDVVSVEACACACGRTGSKLVHYGRAKDRIRFGEIVLDGKDIQDAVYSLVPAPDAWKAVEQADGIRFLLDSHRRKEWSEEGVRARLSERLGVPVDVEFAAEGMLLDRDELVRNAPSKKPVYIQRNGDAAPDAPAANPVRDWLGRGRRKLIDGRFSEARRLFGQATAFDPSDAEAHALLAAAYGRLIEAGNMLEKIKLLPQLEKEIAAALAIDQKLPFARRMNGARLLNTPGTLGGDPSAAAEEFRYCIAHGQADADVWVSLSECYMKLGDSRQAIESLRQALDRSPKHVRANEWMRQLAGNSEASPSDGEVREDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXM4</accession>
    <name>A0A398CXM4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Anti-sigma F factor antagonist</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Stage II sporulation protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">spoIIAA</name>
        <name evidence="7" type="ORF">D3H35_05435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">In the phosphorylated form it could act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma f from inhibition.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04537">
        <property type="protein sequence ID" value="RIE04537"/>
        <property type="gene ID" value="D3H35_05435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045152">
        <property type="term" value="F:antisigma factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014237">
        <property type="entry name" value="Anti-sigma_F_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02886">
        <property type="entry name" value="spore_II_AA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="3"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="117" mass="13151" checksum="58383CCE179B231C" modified="2018-12-05" version="1">MSLQVELEQHRNVLIVRLKGELDHHSADVVRFKMEDAILRGRCDHVVLSLKDLQFMDSSGLGVILGRYKLVKSRGGKMVVCDAHASVKRLFELSGLFKILSLYETERTAIASLEVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXT9</accession>
    <name>A0A398CXT9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore maturation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04607">
        <property type="protein sequence ID" value="RIE04607"/>
        <property type="gene ID" value="D3H35_03685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="177" mass="18832" checksum="100A59A32E9AB943" modified="2018-12-05" version="1">MVSFIQTLSAWTIPMLIAFIPLYAAFRKVPVYETFIDGAKDGFQTAVGIIPPLVGMMTAIGMFRASGAMDALLGWVRPLTESIGIPSDVLPLALLRPISGAGSLAFVTDLIKEQGPDSFVAKVASTIQGSTDTTLYVLTVYFGAVGIRNARYALKVGLFSDVVGFFAAVAVCWLLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXV5</accession>
    <name>A0A398CXV5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Renal dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05368">
        <property type="protein sequence ID" value="RIE05368"/>
        <property type="gene ID" value="D3H35_00860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039498">
        <property type="entry name" value="NTP_transf_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14907">
        <property type="entry name" value="NTP_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="390" mass="44835" checksum="9C3C3A6615487B9A" modified="2018-12-05" version="1">MDKFFSLDLNAFPDELNVMLEAMRSDAEPEDRSARPPSLPNIDWNQFRKLVRHHRVYPQIHANPGSGGLIPSDVLQAFDRDYRQNTLRMLRLSGETERVCRLLAERGVRSLVLKGPALARHLYGDVSLRTSKDLDIIIPVADVRLAERLLQELGYEADRPIPRGLGDWKWKIHHVSFTHPHTGIQVEVHWRLNGDIGKEPTFEALWSGRQRSELAASLYMPGDEHLFLYLVTHGARHGWFRLRWLADIDRMARRSLDWDAIASLLGRYDALDPAGQAFVLASSLLHTPIPRAMRPVVSAGRGRELAQRALGFIRGTAVLSTDPSAGELSKTYKRYLFALKTTRQKGWYAISRLYPSFRDAKALPLPRSLYFLYFPLRPFVWLWRQVRQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYM9</accession>
    <name>A0A398CYM9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide sugar dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_09175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04104">
        <property type="protein sequence ID" value="RIE04104"/>
        <property type="gene ID" value="D3H35_09175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="320"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="430" mass="47754" checksum="3A51D227D114AB48" modified="2018-12-05" version="1">MHIGITRVGVIGLGYVGLPLAVMLAEKGFEVTGIDLDRRKLASLEKGISYIKDISDVRIKEIASANKFKGVADYDALKQVEAIVICVPTPLTESGTPDLGYVQDAGEQIKRRLQKDQVVVLESTTYPGTTREVLLPILEQSGLKAGIDFYLAYSPERIDPGNRSHAVDEIPKILSGVTEVCKEKAFELYSRIYQKVVPVSSTEVAEMAKILENSYRFINISFINELAILCDYLHLDLWEAIQAASTKPYGFHAFYPGPGIGGHCIPVDPLYLQWKAKQSDLNSKFIELADQMNHDMVNYIVDRTEQLLRFVKPLKLARIIVYGITYKSDIADTRDSAAIPIIRKLKKAGADVVYHDPYIPSITIEHESISSVPLTDQELASADVLILLTNHSDLPAQRILDHASLVFDTRHALYGQQGKAKVYQLGEGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ32</accession>
    <name>A0A398CZ32_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05107">
        <property type="protein sequence ID" value="RIE05107"/>
        <property type="gene ID" value="D3H35_02970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="53"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="447" mass="50682" checksum="A1E65DCDC14064BA" modified="2018-12-05" version="1">MGTSRLAWLFDMLENCRSMVKYRNVQYGISMQSENTLEEKMPDNIRVTMLPALNGDSFLISCGTGEDKRNILVDGGMKSTFRDQLCPLLTSMHQKGEVIDLLIVTHIDQDHIHGVIELLTHNESSEAPAIIGIKEIWHNSYLQLQMDKADELTDHQQRVLEEIVARGDGSREDANAKGEISFRQGSTLGALLYEGRYNWNGSAGGRAVTTQSLPVHHLSDELKLELLSPTPEKLQELGQDWLNHLRKNNYIGAPSSDRLFDDAYEMMLRRLKDKSKPKKQPIHSPVRDWELYKEEPYSEDDRATNGSSIAFVLTYRGKRLLYLGDSHPTVIVEGLASLYQEEQRPYEFSAVKISHHGSSGNTSPELLAMIDSPLYLVSTNGSQHGHPECSTLIRIVNRDSRYERELVFNYPHDSAAFMDEQQDKKTELDYKVTIATDIELKRGVCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ36</accession>
    <name>A0A398CZ36_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent helicase/nuclease subunit A</fullName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
            <ecNumber evidence="10">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP-dependent helicase/nuclease AddA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 15" type="primary">addA</name>
        <name evidence="15" type="ORF">D3H35_06120</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -&gt; 5' nuclease activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of AddA and AddB/RexB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the helicase family. AddA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="EC" id="3.6.4.12" evidence="10"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04194">
        <property type="protein sequence ID" value="RIE04194"/>
        <property type="gene ID" value="D3H35_06120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01451">
        <property type="entry name" value="AddA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014152">
        <property type="entry name" value="DNA_helicase_suAddA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF48">
        <property type="entry name" value="PTHR11070:SF48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02785">
        <property type="entry name" value="addA_Gpos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 10 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="13">
        <location>
            <begin position="16"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="14">
        <location>
            <begin position="567"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="572"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE04194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1345" mass="148181" checksum="D07370258F7885CF" modified="2018-12-05" version="1">MTDAIAKRWPAKPEGSRWTDEQWAAIAADGSHLLVAAAAGSGKTAVLVERIISRIADEERPLDVDSMLVATFTKAAAAEMKERIRHALEEALERNPDSGHLQRQLALLPRATITTLHSFCMEVVERYSPVIGLDPGFRIANDTEAELLRMDTLDELFEELYSQEEEAGADEGADKGEFKGELSRLADRFGGERTDEPLHRLVLELHEFAGSHPWPEHWLRQMAGRFNVDDASQLIESLWVSSLRADALLTLRGALHLLDAGLRLTMEPGGPAPYADALRDDRIAVETIVEAMNRDSWSDWRDAIAACSFGRLKPCKGDDYDPELQERTKAYRDTVKKTIAKLSEEWLVRSPEKYAEELRAIAPDMSALAELAISFGQRYELAKREKGLLDFGDLEHYALRILREPSSTAKRSAPSVAAADYRDRYSDIYLDEYQDTNEVQEAIVSLIARSNPGNVFMVGDVKQSIYRFRLAEPGLFLAKYRTYDIWTPETDSPADEGLRIDLARNFRSRREIVEAVNHVFRLIMREPVGEMTYDRRAELVYGNGYPDAGEGDPAGSYGLEMILIDAAGAKPDAGEFSEASEGAGTEEQGDDPSSGLSAQEEEDAETAQLEARCIAAEIRNLMGADDGTGDKKLPFAVYDGKAKLHRPVQYRDIVILLRAATSLAPAFLEELKAAGIPAYADLATGYFAATEVDVMLSLLAIIDNPRQDIPLAGVLRSPIVGLSAEELAQVRLRNRKGSFWDAATAVATVGSAEFSELDAKTSAFVLALESWRSFARKEPLGELLEMLYRETGYYDFVGGMPGGVQRQANLRALVDRARDYERSSRFRGLFRFLRFLGRMRDTGSDLGAARAIGESENVVRIVSIHKSKGLEFPVVFAAGLGRKFNRKDLSGMFLKHKTLGFGPRMVETDTRVTYPTLPQLAIRRKLAGEMLAEEMRVLYVALTRPKEKLYLIGTSKDAAKEWRKWEETASMANAGLPDYAVASASRYLDWLGPAAVLSGGGAAIRSSATGGATAAETGSSASGWNCRIVPSTLFTRQAADAAAALAAGADSEASRAAMWNALVNGESVPTALSADDDRVRRLLSWRYPHEEASAVAAKTSITAMKEKRAYLTEAIAVEEAESEDSFGTWRDRAASEGWTEEPPFLAGDHLADDAVPLSFRMRRPKFLSAKRLTAAERGTAFHLVMQHLPLAEGTGKTDVVILLDSLTEKRILSPDQRKAVDPGEVAAFCDTSLYRRLCAAERVWREVPFTYGLRAEDIHPGSFGGSADETVIIQGVVDCLFAEGDGLVLVDYKTDFLEGTTASQAAEKHRFQVERYGEAAGRILGQPVKEAYVYFFDGGQAVRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZI9</accession>
    <name>A0A398CZI9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proline--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="9">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">proS</name>
        <name evidence="11" type="ORF">D3H35_01795</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="9"/>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05277">
        <property type="protein sequence ID" value="RIE05277"/>
        <property type="gene ID" value="D3H35_01795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01569">
        <property type="entry name" value="Pro_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023717">
        <property type="entry name" value="Pro-tRNA-Synthase_IIa_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001535">
        <property type="entry name" value="ProRS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="38"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE05277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="570" mass="63873" checksum="774931DA3C2064D7" modified="2018-12-05" version="1">MRQSQLLLTTLRESPADAEAVSHQLMLRAGFIRQLAAGIYTYMPLGRRVLRKAEQIIREEMDRAGAQELLMPAMQPVELWKESGRYSVYGPELIRLHDRHDREFALGPTHEEVITSIVREEINSYRKLPFTLYQIQTKFRDERRPRYGLLRSREFLMKDAYSFDADWNGLDQSYTKMFNAYNRIFTRCGINFRAVEADSGAIGGEGGTHEFMALADIGEDTIAACTCCEYAANLEKAEPGILPLEAVAGFDAEPLEKLLTPGVRTIDQLVLSLQIKPADIMKTVIFMVDHNAVAVVVRGDHEINEIKVKDHLGAKSISIADPDTVERVTGLPIGFIGPRGLTIPVLVDHAVLQMPYGIAGANEADYHYRHFNAGRDIDLLQVGHFRNAAEGDRCPSCNEGVLKFHRGIEMGHVFKLGTKYSEKLGATFLDSAGKDQPMIMGCYGIGVSRILSAVLEQNHDEHGMIWPSALAPFHVHLIPISSKDDIQMQAANDLYNRLLENGVEALLDDREERPGVKFKDSDLIGIPIRIIIGKDAEYGNVEFVERRNLKKESISIHDAVARIMEFVSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZJ0</accession>
    <name>A0A398CZJ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04344">
        <property type="protein sequence ID" value="RIE04344"/>
        <property type="gene ID" value="D3H35_07020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="99" mass="12182" checksum="E7C03F325170C4A9" modified="2018-12-05" version="1">MKHHERNVRKANEMRKQLWPIEPRPFGRSFGYFSFHVIERPEDVIPAKRVFRIEQAAQRLDWRIRTVLNHLIHHLRIKLVFTIKLTEKLVILYLWNDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZU1</accession>
    <name>A0A398CZU1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_04350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04721">
        <property type="protein sequence ID" value="RIE04721"/>
        <property type="gene ID" value="D3H35_04350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltrans_SAM" evidence="4">
        <location>
            <begin position="55"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="289" mass="32456" checksum="D54B57B60F030DEF" modified="2018-12-05" version="1">MRMARDWKDYELLDTGNGEKLERWGDVILRRPDPQIIWPIASESGAWKQADGHYHRSSSGGGQWTFRKTLPERWSISYGPLRFHIKPTSFKHTGLFPEQAVNWSWMMDKIRSANRPISVLNLFAYTGGATVASAAAGADVCHVDASKGMVQWAKENAQLSGLADASVRYITDDVFKFVQREQRRGRKYDAIIMDPPSYGRGPNGEMWKLEENLFPFLQSCTEILSDNPLFILVNSYTTGLSPTVLNNLLDMAIGRKFGGKSDCGEIGLPITKSGLTLPCGIYGRWESDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D030</accession>
    <name>A0A398D030_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_04965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04821">
        <property type="protein sequence ID" value="RIE04821"/>
        <property type="gene ID" value="D3H35_04965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="242" mass="25985" checksum="66BCE9D007BD8CB8" modified="2018-12-05" version="1">MANSVEPLIQITNLSKQYRMGGELVKALDDVSLTVYPGDFLAIVGPSGSGKSTLMNVVGCLDSPTSGDYWLDGEEVSRLKENKLADIRNKKIGFIFQGFNLLNKLSAIENVELPLIYRGIPAKARRELAAAALVKVGLDGRMDHRPSELSGGQQQRVAIARALAGNPPILLADEPTGALDTKTGKEVMGFIRELNGLGHTIVLITHDPGISLQAKRVVRIQDGRLSEEEKGGALPDELHAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0N3</accession>
    <name>A0A398D0N3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04724">
        <property type="protein sequence ID" value="RIE04724"/>
        <property type="gene ID" value="D3H35_04365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="112" mass="12959" checksum="D23873DDCC80F221" modified="2018-12-05" version="1">MKMGERLRELRLRRNISQEEVARNIGITRSAYSHYEINNRQPIYETLIKLATFFDVSLDYIVGGVPAASETTETKDVLHILRMLQTMDPEQRQASIRLMNDLIHNNRAENGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1D3</accession>
    <name>A0A398D1D3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">50S ribosomal protein L7ae-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_02210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE04984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04984">
        <property type="protein sequence ID" value="RIE04984"/>
        <property type="gene ID" value="D3H35_02210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_L7Ae/L8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000948">
        <property type="entry name" value="Ribosomal_L7Ae_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00884">
        <property type="entry name" value="RIBOSOMALHS6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="8">
        <location>
            <begin position="9"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="84" mass="8970" checksum="CE69D0C62998995B" modified="2018-12-05" version="1">MTTNDYGLQAGNVKIGTKQTIKTVEQGDAAEVFVAQDADPRTVARVIQLCEQLGVKLTYVDTMRNLGKACGIEVGAAMAAIIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1I8</accession>
    <name>A0A398D1I8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_00815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05361">
        <property type="protein sequence ID" value="RIE05361"/>
        <property type="gene ID" value="D3H35_00815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005976">
        <property type="term" value="P:polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="MannoseP_isomer" evidence="2">
        <location>
            <begin position="299"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="456" mass="51411" checksum="1E5D150DE7F2C323" modified="2018-12-05" version="1">MKIVLLSGGSGKRLWPLSNDSRSKQFLKVLKDPAGRQESMIQRVWRQIGEAGLREHAYVATGKAQVEIISGQLGNDIRLIAEPERRDTFPAIALAATYLYAMEGVSLNETIVVMPVDSYVSGDFFRQLERLEGALETSGADLALIGVQPTYPSEKYGYILPYPEEGSDRPFARVRGFREKPGKEEAEAMIREAALWNCGVFAFKLDLLINILIAQELPIHYEEMRKRYGSLPQISFDYEVVEKANRIAAVRYDGDWKDLGTWNTLTEEIDTALIGKGMISERTKNAHVINELEVPIAVLGLSDVIVAASPDGILVADKALTPLVKEMLKHSEQRPMYEERRWGRYRVLDYRTYPDGREVLTKWIFIASGRNLSYQYHSLRDEVWTVVAGRGSVVLDGRQLAVSAGDVLLVPKEARHSVRADTDLEIVEVQTGTLLIEEDIVRLELEWDEIVQLCKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D271</accession>
    <name>A0A398D271_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05204">
        <property type="protein sequence ID" value="RIE05204"/>
        <property type="gene ID" value="D3H35_01395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="342"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="456"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="740" mass="84487" checksum="15771B3353474D73" modified="2018-12-05" version="1">MSIESFCKELGVVVKEGVNLVENFKKILSNNVKINCLLIFDNALDEEKLSNYIPYNYPNCDIIVTSTNPNWRNSLPIDILLPEDACKLISSSTNANEGDESVALELCSELGYLPLALEQAAAYIREVGLSIYEYLQKFKKYRAELAVQGKPLNYDKNIATTWKLLLNSITENIEITHNLFTYICFLAPDRISKDYLLNKKISPVSDTTITSELILDKIIAQLRRLSLVKIVDGRISIHRLVVAMTIDLLESEQRAKWIQLHVDTVLSANKEQRTGSELLHHRDYLIKHIIDNQIFNENIAELIASQAKVHLALSYYENALSLSMFLYTNTTTYLNNSPELLAEAALRLGAFHFTQGHYIEARNFLLEAYQSLPENSENLLNVLNTLINVERESGKFESALEYLEKAEQFIATTTGNDGYDAILNSKGRVLIALSRYDEAEITLNKSLETAREYDQPSILSNLGQVYEKKGDLKKAIQYYHKSIEISKKYFQEAHEHFAREYSNLGLAYYKLYDAFHAKRYLRKALEIISEINPLPNIVTAHITNNLGMAYELDNKIDDALKYYLKSKEIFKLLNQELNEDNSNVLYNIGGAYQFLGNFKEAELHVLQALAIDRAIFKDNHPEVAKDLGKLAVIMMDINNYKKAVDYLNQSEKIYRNNGLTNSLDYASTIGHRASALYMIGQNKAAKADLKNALAIIHQNYGQENQLAYNLFNTFVSFILKTNNLQKEAEFIIFIQNNYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D2N2</accession>
    <name>A0A398D2N2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_00645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKC lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05334">
        <property type="protein sequence ID" value="RIE05334"/>
        <property type="gene ID" value="D3H35_00645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008844">
        <property type="entry name" value="Spore_GerAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038501">
        <property type="entry name" value="Spore_GerAC_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05504">
        <property type="entry name" value="Spore_GerAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="147" mass="16788" checksum="45213EAE06064475" modified="2018-12-05" version="1">MVGMRWMARKISNVIINVPSEGEVAASVALISSRFRVLPTVRNGTVKFDIRAKLTGYIIELNKNESVALLGKEAAEVIKNDLLNTYRYGLKAKCDPYFLRHALYRDYPRIYRKLIAEEPFFLKEDSLGKVEVKVELTNTGKYKGRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CB35</accession>
    <name>A0A398CB35_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_28450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00356">
        <property type="protein sequence ID" value="RIE00356"/>
        <property type="gene ID" value="D3H35_28450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="257" mass="27590" checksum="F6445562EF74BD03" modified="2018-12-05" version="1">MRLQGKICLITGSGSGIGRSTAVRFAEEGAVVIVNDLNDRDGNETVAEIRSNGGEAFYYGANVTEPDKVEAMVADIIAVHGRIDVLFNNAGISGVGKLHETELAQWERVLQVNVIGVYIVSKAVLPHMMERRNGSIINMSSCIAEIGLAQRAPYAASKGAVLSLTKSMQVDYAPYHIRVNALLPGTILTPFVERYLKESYEDPEAGYRSLKARQLSGDLGRPSDVAQAAVFLASDESTFVMGSPFYVDGGATFGKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CB65</accession>
    <name>A0A398CB65_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_28620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00386">
        <property type="protein sequence ID" value="RIE00386"/>
        <property type="gene ID" value="D3H35_28620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="278" mass="33583" checksum="A7C48E5E07CBF1DE" modified="2018-12-05" version="1">MCAGGQQWYEIPHIRRKVCAGGQQWYEIPHIRRKVCAGGQQWYEIPHIRRKVCAGGQQWYEIPHIRRKVCAGWQQRYEIPHNRRKVCAGGQQRYEIPHNRRKVCAGGQQWYEIPHIRRKVCAGWQQRYEIPHNRRKVCAGGQQWYEIPHIRRKRCAGGQQWYEIPHIRRKVCAGWQQWYEIPHIRRKVCAGWQQWYEIPHIRRKVCAGGQQWYEIPYIRRKVCAGGQQWYEIPQIRRKRCAGGQQWYEIPYIRRKRCAGGQQWYEIPHIRRKVCAGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBV2</accession>
    <name>A0A398CBV2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00636">
        <property type="protein sequence ID" value="RIE00636"/>
        <property type="gene ID" value="D3H35_27105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="265" mass="29012" checksum="5C750CD4C6155090" modified="2018-12-05" version="1">MAYSIIALDIDGTLLNDDHKLTPRVIAAVRSAAEQGAEIVLCTGRGSSSALPVLNELGMQGTMITHNGSSIVDSATRSVIYEMAIEPELANRYQSYLRERQIHFDMNTSFELYVDSLPEDIAAMYERFHVLPVVRSPEDALPAGTVKLSVYAPSSVLDELERDWTDWAHDLQTIRSGDFFIDIQHPHATKGKALERLAAMRGVARERILAIGNYYNDIGMLSFAGFGIAMDNSPAEVKAEADEATASNNEDGVALALERHVLSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCJ3</accession>
    <name>A0A398CCJ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02175</name>
        <name evidence="1" type="ORF">D3H35_29040</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00453">
        <property type="protein sequence ID" value="RIE00453"/>
        <property type="gene ID" value="D3H35_29040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05198">
        <property type="protein sequence ID" value="RIE05198"/>
        <property type="gene ID" value="D3H35_02175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="258" mass="28375" checksum="0C937DA3C660B474" modified="2018-12-05" version="1">MHLLAEESSRFNERLAVYETTRLYGETGKYRILQFADAAVQGAADLKNPSRIVLPYQRALLHLMERNVPSLEDVFVIGHGIGSIAGQYPHKRFVVAEIDEKVVELSRLFFNYRLDNVIVGDGRTILLDQAANAFDCIILDAFNSNGTPGHLVSVPFFDLTADKLDSRGILLVNVVGKAVNDKLVNAIHSSMRQAYGCTKAFFLPGEDDDRSGNVLLTGSGGVIEYDAGQMAGFAEIELEEGYPIRDGRAYISGSSRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCS7</accession>
    <name>A0A398CCS7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00510">
        <property type="protein sequence ID" value="RIE00510"/>
        <property type="gene ID" value="D3H35_27570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="99" mass="10318" checksum="00D54098782FA325" modified="2018-12-05" version="1">MESGQCPSTKAGKNRAIIGTTAARERRHDRAACQSVFDRTPTAADRSGAGWIASRGGKIGRRAATGDPEEKGGEASRDPSGKLADARSLRGSRKASCFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD38</accession>
    <name>A0A398CD38_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0178 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000050">
        <property type="protein sequence ID" value="RIE00623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00623">
        <property type="protein sequence ID" value="RIE00623"/>
        <property type="gene ID" value="D3H35_27445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003791">
        <property type="entry name" value="UPF0178"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35146">
        <property type="entry name" value="PTHR35146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02639">
        <property type="entry name" value="DUF188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="92" mass="9778" checksum="1DA80AEA0298F60B" modified="2018-12-05" version="1">MVLVRNRVVVDGDACPVKSEIARTVQSLDATALMVSSHAHRLVAEDRVSVVTVDASNQSADLYIANVLTRQDVLVTGDYGLAALGLARGRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDB5</accession>
    <name>A0A398CDB5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01176">
        <property type="protein sequence ID" value="RIE01176"/>
        <property type="gene ID" value="D3H35_22510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="32"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="182" mass="20477" checksum="E602E1AA807416FB" modified="2018-12-05" version="1">MERTVTNQVTGEQITFIETAEDTDGKYLLIEVALPPYGKGPPLHIHDRFEEEFEVVSGKLTVTLGKIKHLLEAGDCRTVPLKTPHTFTNNDEEPVVFRVRLTPPSQFEQSVRIHYGLMDDGLTDAKGNPKLLAHTALVLSLQNTLIVGIPFWIQRSIFGLIVKRARKRGIYAKLEKYTGKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDP5</accession>
    <name>A0A398CDP5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01306">
        <property type="protein sequence ID" value="RIE01306"/>
        <property type="gene ID" value="D3H35_23265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="129" mass="14621" checksum="77A2B2C1640E7753" modified="2018-12-05" version="1">MRAQITSLEEPVYVLAVQGVRPVDITASLECNREKVAATLERMEKRGVIKRIDRGQYSAVFDEYEVVETRRKSLGHNKARNELRVPPEIEAFVRANYGIMARREMASCLGVHKVALNELIIKLRLGRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE94</accession>
    <name>A0A398CE94_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_24390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01496">
        <property type="protein sequence ID" value="RIE01496"/>
        <property type="gene ID" value="D3H35_24390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="33"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="215"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="457"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE01496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="545" mass="56551" checksum="A9B69A7EE211A24C" modified="2018-12-05" version="1">MTDFKKLGISEKRVAALKNIGIAVPTPIQERAIPALLEGKDIIGQAQTGTGKTLAFALPLLQRLKPGADGVQALIVSPTRELALQITTEIKKLIVAGEEVRVLAVYGGQDVEAQMHKLKGNVQVIVCTPGRMLDHMRRGTVELGSVSTLVLDEADQMLHMGFLTEVEEIIKAVPYKRQTMLFSATMPAGVRNLASRFMRDPLDVTVKATQVTVKDIRQWAVETSDRAKQSTLRKIIDEQRPYLAVIFCRTKRRASTLNQALQEMGYDSDELHGDLSQAKREQVMKKFREAKLQLLIATDVAARGLDVEGVTHVFNYDIPIDVESYIHRIGRTGRAGGKGLAITMVAPRDKPELVRIEQGIKQTLEKKRYGSDQGDGLEEELIAQLKAEKHGRGFSGGGRGAGGSGSRSGGSGAGARGGSGARGGRSGASGSRGGSGGGSRGGAAGAGAARGGSGSRGASGSRGSSGSEATFGSGSGGGFGATGGRRSGGGAGSSAGKGGAPGGRPGSRGPGGGFGSRSGSGGGGGGKPADFRKSPIRSQRNAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEQ6</accession>
    <name>A0A398CEQ6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cu_amine_oxidN1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_22610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01193">
        <property type="protein sequence ID" value="RIE01193"/>
        <property type="gene ID" value="D3H35_22610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017215629" description="Cu_amine_oxidN1 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="2">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="361" mass="39462" checksum="727EE694C5D168BD" modified="2018-12-05" version="1">MKRFIMGLICGLALSGASIAVAAVSNEVKATLFPSELRFYIDGKDNTGTEEVSVLKYNNRMYIPLRVFAEKLGSTVDYHAPKPGDTWASVDIFKVDDRDLTVRDTAGYVGMGHVDVQFAEHPTYLVSTPQITGAVKFYKTIPKGKQVVVAVLDKDNQQVAVTEPIQLRSRAVGDMAAGEVATFETNFPYVNPVEGYKLQARLVDETSWTYEQIDGVIQGAGGMTGNPLGVSIGSEHEVKKGQPVEIKVHMVNLSDSDTIVLSQPVSLEVQITKRNGDSQQLIRTLRTAPLTGTIYWRQGSAFTKLVWDQKDDKGRAVPAGEYTASIVLPTKAVGAAIKKPNTTQEYTIDSSMQTQFPIVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEZ9</accession>
    <name>A0A398CEZ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4956 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01766">
        <property type="protein sequence ID" value="RIE01766"/>
        <property type="gene ID" value="D3H35_13260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032531">
        <property type="entry name" value="DUF4956"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16316">
        <property type="entry name" value="DUF4956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="226" mass="24879" checksum="B2999C1F8C035B89" modified="2018-12-05" version="1">MIESLFTAATESSTLTLTDALLTIFISIALGAIISFTYMRTQVGYTQNFALTMIVLPAIVAIIILLIGSNIARAFSLAGAFSIIRFRSAPGDPKDIAFVLFTMAAGLACGVGSFGYAVLFTIILCLLMFVLKVTKFGSKKATQKLLKVTIPENLGYEEAFDEIFKKFNIDYELRKVRTTELGSLYELVYAVTIDHLTNQKEFLDAVRCRNGNLDITLTMSPTTSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF22</accession>
    <name>A0A398CF22_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_22475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01170">
        <property type="protein sequence ID" value="RIE01170"/>
        <property type="gene ID" value="D3H35_22475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="338" mass="36050" checksum="8170CC1E539D7B03" modified="2018-12-05" version="1">MKLENVSTTNKPFNQVKAWGILLSAVGLLLLVSILGLAVGWYAFSLSELETIWNRDPETTHHEIIVKIRLPLLLTTLVGGMGLAAASVILQRVMRHRLADTGIMGLTEGGAFAACLVVLYKPDAAYPWYIAAIGLGTIVLGAFNIIFARKVRGGSLAVRSMLVGAIMIMVLLGCARLIVLFTDDLLNNVIQVYLGSSGAVYENWLLPCFALGLLGAIAVIAFKPSTDRARKGVLLASAVVVIVLSMGAAAAFGAIAFVGMLVSLLARRLVGGSEGWVLAVSTVLGAIVMVTLSIINRTLAAPYELPLYVLISMFGAPISLYLFYRSLMNPHKPTDGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFM8</accession>
    <name>A0A398CFM8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Inositol monophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01310">
        <property type="protein sequence ID" value="RIE01310"/>
        <property type="gene ID" value="D3H35_23290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="267" mass="30108" checksum="DCF9EE092A55F0BB" modified="2018-12-05" version="1">MDRRVIQLAKKESIRIIRQAGQIAKNKFDNLVDIRSKGDSGDVVTEVDHMAEEIIINHIQSLFPDHQIHSEEAGLIGTPSDWQWLIDPLDGTNNFAIGLPIFTTSITLMYRKAPVLGVIYEPWTDRLFVSALNEGASCNDRPIHMKHSPNFLKGNIGWIQGHKVQNDPKAVILRQHIDVSFKRMLRLWAPTLQWCMLAKGDLDGIVLYNSEGDDLYSGVLMVKEAGGSVIDFEGIPFEGMSEEPYLIACHPDHKHDLLKIVKQGLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFY6</accession>
    <name>A0A398CFY6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AbrB/MazE/SpoVT family DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_23870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01410">
        <property type="protein sequence ID" value="RIE01410"/>
        <property type="gene ID" value="D3H35_23870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="6"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="84" mass="9462" checksum="26959A265AFD2363" modified="2018-12-05" version="1">MMKSTGIVRKVDELGRVVIPIELRRTLGIGEKDALEIYVDGERIMLKKYEPACIFCGNAENVTYFKGKIVCRECLNDLPSPVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG12</accession>
    <name>A0A398CG12_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DeoRC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000046">
        <property type="protein sequence ID" value="RIE00862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00862">
        <property type="protein sequence ID" value="RIE00862"/>
        <property type="gene ID" value="D3H35_26045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DeoRC" evidence="1">
        <location>
            <begin position="29"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="96" mass="10758" checksum="F1C8BC90EEBC6455" modified="2018-12-05" version="1">MAALRPFQHERLLSSFIWINARWRWMKNAESKAAADLVENGDSIILDSGSTTIEIAKQLVNHTKLTIITNDLYIASTVAFHPSTQVMVTGGMKRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG16</accession>
    <name>A0A398CG16_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_22400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01663">
        <property type="protein sequence ID" value="RIE01663"/>
        <property type="gene ID" value="D3H35_22400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="46"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="252" mass="28298" checksum="FAE91C19045C38ED" modified="2018-12-05" version="1">MYPALWVVMSSFRPGTALHSEQLIPHSFTLEHYRTLFDKYPFAQWFANTLKVSFFTMIFSTIIVTLTGYVFSRFRFKGRKKIMLGLLVIGMFPGFMSMIAVYILLLQLKLLDTHMALIVVYSAGASMGYLYVKSFFDTIPSSLIDAAKIDGASHWTIFVKIMLPLSKPMLVFIALTSFSSGFVDFIFANMVLTDDDKLTLAVGLFKMVKIKFATEFTLFAAGCVLVAVPITLLFVFLQRFLIEGLTAGAEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH34</accession>
    <name>A0A398CH34_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Asparagine synthetase B family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_13310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01775">
        <property type="protein sequence ID" value="RIE01775"/>
        <property type="gene ID" value="D3H35_13310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="2">
        <location>
            <begin position="43"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="676" mass="77639" checksum="A43A5F2DFED4556A" modified="2018-12-05" version="1">MRIGLFFFAKVLWSNSGPSRKEYPSNKFCSKWRKRKGDERRMSAIFGQYSLPREPLNQEDLQIMLQTYKSKYEYDRLQIRETKGVGLGCLLQCVTLESRQEELPFRDSESNVWITADAILDNREELVRLLGLLPGEGEIVTDSRLILASYLKWGDRCAERLNGIFAFAIFDGRNDEMLLVRDQRGMRSLAYTIRQSTLYFASTVAPIAKVAPSRYSKQWLQNYLTAPFVAPDTDEYRSIYEGIRYLPPAHIMKVKDGKAAFRPYWTLERPFELSLASDEDYEERFRSLLEEATKASLRTDSSVGILLSGGLDSTTVAAVAAPMLEREGRRLHSYTHVPISTFKHNGKELVNERPLVEELIDMYPSISPTWVENEALHAFNVIDDWVDILDQPFSFFGNAPWMLSCYEQAAKKGHRVMLNGKNGNGSISFGPLNAHYSYLRKHGRWLELARETWHQKRLRDISWLRAMRIVAGNALSHRGSSKLIAEVRAGLSLVFSPVILEHSTWNDMQNKKDSPFDLMLQLSAPHKTHHQGVIHTLLSLKYNIVTRDPTGYVPLLSFLASLPFEQFVSKGVHKRLLRRAYSDKLPASILNLTRDKGIQSADWLHRIEHEHDSILSAFMECIGDSNIRTSLNQSIMQSGTDQLRSLLRQWYPASSIFRCITIERYMRHGFKGGEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH52</accession>
    <name>A0A398CH52_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_13430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01795">
        <property type="protein sequence ID" value="RIE01795"/>
        <property type="gene ID" value="D3H35_13430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="237" mass="27252" checksum="103D1D353801A0CF" modified="2018-12-05" version="1">MYNTYIFDLYGTLIDIHTDENSPELWERLSLHFRYSGISAEPKELAREFQEEIGRQMAAPRVKCEYPDFDMLETFETIADRRGVKPAPGWAAETVRWFRQLSMRRLQLYDGVEETLQSLKARNKKIYLLSNGQKTFVEAELRVLGIYDYFDGIAISSVAGISKPDPLFYDYLVQEYGADLSSAVMIGNDSRTDIEGARRAGIDGCYIHSNSSPDVKEVDCKYQIWDGDFHRVLKLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHF6</accession>
    <name>A0A398CHF6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00348">
        <property type="protein sequence ID" value="RIE00348"/>
        <property type="gene ID" value="D3H35_28395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="283" mass="30653" checksum="2926F5A7D9EA8D56" modified="2018-12-05" version="1">MKILVTGATGQLGALVVDKLLQTVPASDLAISVRNPEKAAHLQERGVDVRQADFEQPETLEKAFAGVDRLLIISTAGENRIEQHKAAVNAAQKSGVSFIAYTSVVNAQDSTAALASDHRETENLIRQTGIPYSFLRNNWYIENEAGSIQAAAQGVPWVHAIESAKVGWATRLDYAHAAAAVLTQEGHENTVYELSGQLRTMDELIEIVSEVLGRDVQVQNVSDAAYSDIMRGAGLPDFLVAIFTDMQKAIRQGALAIESKDLEKLLDRPAQPLDEAIRAIVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHG3</accession>
    <name>A0A398CHG3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF393 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00529">
        <property type="protein sequence ID" value="RIE00529"/>
        <property type="gene ID" value="D3H35_27685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007263">
        <property type="entry name" value="DCC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04134">
        <property type="entry name" value="DCC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="162" mass="17770" checksum="D3547BAB00497910" modified="2018-12-05" version="1">MKREESTRMGNFPKLTLVYDGECNLCLAAVDKIKSMKVRANVTFVPLQALVNGKLQPWPGIADVPLDELAGQMHVTDESGRRHSGSDGVLLLLRHVPSLAWLGVLGNIPGLRGISRLAYRIVARNRYRLFGRASCSDGVCSLPRGNQTNLQDGGAPPHDERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHL2</accession>
    <name>A0A398CHL2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_16155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02263">
        <property type="protein sequence ID" value="RIE02263"/>
        <property type="gene ID" value="D3H35_16155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="140"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="359" mass="38663" checksum="49C5CFFD4C9CBE6B" modified="2018-12-05" version="1">MSKKVKIGIIGSGGIAGAHVSAYRKLPFVEIAAVADVIPGKAREFVDKHGLEHTAAFDSHTDLLAQSLDGVSICTPNVSHHRTTIDSLRAGKHVLLEKPMSVTLAEAVEMVQVQKAAGSMLTLGFQPRYDPNMKKLQDIVQSGRLGNVYYVETGGGRRRGMPRGTFVSKRLAGAGAMADIGCYSLDMALNTLGYPRPVSVSAFTSNHFGTNSLYHPEADKFEVEDFGVAMVRFENELVLQFKISWAMHMDTLGATMFLGTDAGLKVTPAGSGPWSGVWDGAIGEMTLFHDDFGGHTSTAVPLIGHSLNLFDEKVRDFAEAVRDGRSAPIPGEQILIQQAIIDGVLRSAEARREVSVELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHY5</accession>
    <name>A0A398CHY5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01622">
        <property type="protein sequence ID" value="RIE01622"/>
        <property type="gene ID" value="D3H35_25095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02857">
        <property type="entry name" value="E_set_CDase_PDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004185">
        <property type="entry name" value="Glyco_hydro_13_lg-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02903">
        <property type="entry name" value="Alpha-amylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="136"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="579" mass="67681" checksum="461CE2D6CD2C1207" modified="2018-12-05" version="1">MISNFYHDPALDTRLSSSKELDIRLKLPKEATQAELWIWNKVKWEQLGIEQIPLTRWAETEELAYYRTVWMSMEPRVRYLQYTFKFQLGGRIQWLNADGLHDTPERPVKGAFEFPYGGDRDAVHVPDWIKDRVWYQIFPERFCNGDRENDPVDTVPWGTPPTRDNTMGGDLQGIIDKLDYLSQLGINAIYLNPIFKAKSNHKYDTLDYFAIDPQFGSIEDLRRLTELCHRRGIRVVLDLVINHCGYDHPYFQDVVQNGEKSPYRDWFYVHEYPVALSDSKYDSVWYYQWMPKIKTSNPQVKQYVFDIVSFWQKETGIDGWRVDVADEVELSFLRELNSHVKQINHNAIIIAEIWHDAKSLIMSGGVDSAMNYDMRSIMFDYVLDQSITIEQFHARLTRYAHRYAAAELNQMYNLLGSHDTERIMTRSGDRVDHLLLLIAMQYMLPGNPALYYGDELGFVGENDPGCRACMKWDDRYEYQPLWVYLRNWNRMKTSNAALQKGRLELQLAASENLYAIKRIDGERQAVAVFNFSNEAKELSLIGTVFGLSIEQFQKASFPYQIPEDRIAAGHFVLLLNDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI22</accession>
    <name>A0A398CI22_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02443">
        <property type="protein sequence ID" value="RIE02443"/>
        <property type="gene ID" value="D3H35_17210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="128" mass="14287" checksum="621556727ED9A9A3" modified="2018-12-05" version="1">MPILLTADKSNVLVNGKAIEGLQEITYRTVKPHIDLPSIGSDERMGIAYGMTEVRGYLRVISASDDLDQLFINKTPFQIFAQLKHTASTGDMTKEITLDDCYMHKKSFALKASGVAEVIYKFSATRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI37</accession>
    <name>A0A398CI37_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DegT/DnrJ/EryC1/StrS family aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_26930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00819">
        <property type="protein sequence ID" value="RIE00819"/>
        <property type="gene ID" value="D3H35_26930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="387" mass="42284" checksum="3E6910115CF520C4" modified="2018-12-05" version="1">MPFVIRSCVIGGSNMGILLSAPQTEFEIIEEEWRDAVKQIAKRGEFIGGASVARFEKAFAEYIGAQGMVGVGNGTDALILALKSLGIGPGDEVITVANTFVATVAAIHHVGARAVLVDCDERTYLMDIGKVTQAVTARTKAIIAVHLYGQMVDLHELLPWAEERGIAVIEDGAQAVGARLYNRAVGNWGQLACFSFYPDKNLGAFGDAGGITGSSPELLSTLRKLRNHGGEMRYQHELPGFNSRLDPIQAIALDIKLKYIEQWTAKRIQIAKWYEHELNGISNVVLPCHRNDQSHVFHLFVIRVPDLARSSLMKHLQKKGILTGIHYPTPVHLTPAFSYLGYGPGDFQTSEKASKEILSLPMNITVSEQDVETVAKEIRNLLGGVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI78</accession>
    <name>A0A398CI78_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_11530</name>
        <name evidence="3" type="ORF">D3H35_25950</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000044">
        <property type="protein sequence ID" value="RIE00879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00879">
        <property type="protein sequence ID" value="RIE00879"/>
        <property type="gene ID" value="D3H35_25950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03312">
        <property type="protein sequence ID" value="RIE03312"/>
        <property type="gene ID" value="D3H35_11530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="179" mass="19362" checksum="9BE83ADF390AD256" modified="2018-12-05" version="1">MHKYRSWLMGLGIGIILGASMLQLILLAKGLQTSEKNGSEAITREQFESYAKEQGLAFYPSAEKRYSEDELAAKIDAAIAALPEQTDRAQDAASPKADSAESNGKEPSDGSSEEKSIRVEYNDTLIIVAGKLKDAGIIDDEADFLKQANSISKKLKVGTSTFTGKPAYSEIMKHLTGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIE8</accession>
    <name>A0A398CIE8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000051">
        <property type="protein sequence ID" value="RIE00618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00618">
        <property type="protein sequence ID" value="RIE00618"/>
        <property type="gene ID" value="D3H35_27550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="173" mass="19898" checksum="7ACBED6BF7E8A2CE" modified="2018-12-05" version="1">MLVSFKLRIVHQEERKHIKLVYDRSEATQRTYAPQSFIGLLVADLEKGKHFVEVDLDDPFFRVFTVSAEAPIDFGRIGLHSAHLSLDYGNPADPATLKHADFVFDKDRAEARRFEVFMNERLDTDYEYSVQYHFDPLSGWEGSKTSYEQPPGERKIGRCCSILSRTSGFLSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIQ5</accession>
    <name>A0A398CIQ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fe(3+)-hydroxamate ABC transporter permease FhuB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fhuB</name>
        <name evidence="8" type="ORF">D3H35_21895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01079">
        <property type="protein sequence ID" value="RIE01079"/>
        <property type="gene ID" value="D3H35_21895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="576"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="614"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="644"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="666" mass="69152" checksum="7481D0D2D76355C9" modified="2018-12-05" version="1">MLVAGLIALAVIVFVSLTQGLAHVSVRSVIEALLSPQPDVTEHQLIRGMRLPRTVMGLLAGAALAIAGALMQSVTRNPLASETTLGVNAGAYLVVVVGTIFWPAILHQYSLLFAVAGGAGAAAAVYVMGGGRKSTPVRITLSGMIVTLVCGAITSALQMLNEQSTQGIFLWGSGSLVQNDWDGVQFTWLWVIGGIAAVLLSVRHLDLLAFSEDTARSLGQKIIVIRAFAMGVAILLACVTVSVVGPIGFIGLMAPHIVRLTGLTRHGWLIPISAVWGAVILVGADTIARAFIASYGELPAGAITAIIGAPWLIWLALRTAHRADSASAGASAVRLSGGSGFIPYKVWVVFLTALLVAVWIFNLMSGALDLTVWEVLQALTGGGDEMAKQIVLDFRLPRLLTAGLAGMALAISGTLLQSSVRNPLADPQVVGVTSGAGFGAMLLMLVVPGAAAGWIPVGAVIGGVAAAAVVYASAWRRGLSPTVLVLVGIAVSAAGSAFINLFVIRAKLTLAPALAWLAGSTYGRSWSEVWLLLPLLLVLAPIAWWMGRRVDLLSFSDESSTGLGLSVRRTRLATGLIAVLLASVAAACVGSIGFIGLLAPHASRMLAGTNHRRSMLLSALLGGVLLATADWLGRTVLEPKEIPSGLVAALMGAPYLFLLMMRSRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIT8</accession>
    <name>A0A398CIT8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9 10">Xylose isomerase</fullName>
            <ecNumber evidence="2 9 10">5.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">xylA</name>
        <name evidence="13" type="ORF">D3H35_16330</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9 10">
            <text>alpha-D-xylose = alpha-D-xylulofuranose</text>
            <dbReference type="Rhea" id="RHEA:22816"/>
            <dbReference type="ChEBI" id="CHEBI:28518"/>
            <dbReference type="ChEBI" id="CHEBI:188998"/>
            <dbReference type="EC" id="5.3.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the xylose isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.5" evidence="2 9 10"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02290">
        <property type="protein sequence ID" value="RIE02290"/>
        <property type="gene ID" value="D3H35_16330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009045">
        <property type="term" value="F:xylose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00455">
        <property type="entry name" value="Xylose_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013452">
        <property type="entry name" value="Xylose_isom_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001998">
        <property type="entry name" value="Xylose_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00688">
        <property type="entry name" value="XYLOSISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02630">
        <property type="entry name" value="xylose_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51415">
        <property type="entry name" value="XYLOSE_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="12">
        <location>
            <begin position="139"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE02290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="437" mass="48786" checksum="8A67E26F4CF4ACD5" modified="2018-12-05" version="1">MAYFNNVPNIQFEGRGSKNPFAFKHYNPQEVVLGKTMEEHLRFAVAYWHTFTASGVDPFGAGTAVRSWDSLSPLDKAKHRVEANFELLQKLNVPFYCFHDADVAPEGATLAETNKNLDIIVAQLKDFQKSTGKKLLWNTINAFSNPRYVHGAGTSNNADVFAYAAASIKKGLEVGKELGAENYVFWGGREGYESLLTTDMGLELDNLARLLHMAVAYAKEIGFDAQFLIEPKPKEPSKHQYDFDAATALQFLQKYDLKRYFKLNIEANHATLAGHTFEHELRVSRLNDALGSIDANQGDMLLGWDTDEFPTDLYSTSLAMFEILKNDGLGRGGVNFDAKVRRSSFEDEDLFFAHIAGMDTYARGLKAAAKLIEDRVLDDIVDNRYRSFREGIGADIVSGKADLKSLEAYALKLGTIKNESGRLEQIKSTLNDVIFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIY2</accession>
    <name>A0A398CIY2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MmcQ/YjbR family DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02042">
        <property type="protein sequence ID" value="RIE02042"/>
        <property type="gene ID" value="D3H35_14860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35145">
        <property type="entry name" value="PTHR35145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="117" mass="13496" checksum="8F22D63C49BCBBA3" modified="2018-12-05" version="1">MNHETLIAYGLKLPGSSLKYPFEPDLPVLYVGGKMFALFGSNGARQSVNLKADPEEAWLMRQQYPESVLPGYHMNKRHWNTVVLDGTVPDEEVTEMLDQSYRLVFGKLPKRIRQEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ58</accession>
    <name>A0A398CJ58_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02375">
        <property type="protein sequence ID" value="RIE02375"/>
        <property type="gene ID" value="D3H35_16810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="252" mass="28677" checksum="E57203278B11AD22" modified="2018-12-05" version="1">MQTTASRYANELEQIHKDGYVLFRNVLNQDQISEVKAGIQQAFDGKGQEVMLQGPMFEKGGIFETLVDFPGVVDFIEEVIGPDVQLSSMNGMRTLKDTGVSKWHVDEALFFPLPEGLEIDERIPMPVYLVNALYYLDDITEDLGPTQVVPGSHRAGKRLNFSEDIDLYKGREPVSVLAKAGDCLVFNSQVWHRGAPNRSDSPRFVQQIIYRQKFIVPHMSHDNNAAYRAPMELIQRSDARRRRLLGYNDQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ60</accession>
    <name>A0A398CJ60_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_23000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01259">
        <property type="protein sequence ID" value="RIE01259"/>
        <property type="gene ID" value="D3H35_23000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="PFTB_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="796"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="858"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="922"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="981" mass="103252" checksum="1EE26C33919C2713" modified="2018-12-05" version="1">MYLRGIGEVWLQRLRVSRDSSEFARFDVETSVYPKSSINRSILHREGVFLRRAFASYFFGESGRMLRKPSTAKRSQRGAWWRGAVALVLAMQVVLGALAGIASAEEAAKPAVGPTRAQVTEALQALQAQLAKAEPVSDWAAFGLARSGKPVASRYLPVAAKSVDDGSLRLVTDFARTALAINANGGDARKVGKGSTDLLGKIANFEKMTAQGPNAPAYALMALDAGDYTPGAKDRWTRDDLIKWLADNRNADGGWSLTPGKSDTDVTAIVLTALAPYQAREDVKPVVEKALVWLSSIQKETGGFGSMGESSESSVQVLIALTSLNIDPVNDSRFVKNGKSALARLLEYRQSDGQFSHTAEGKADAMATFYALLGLTSVDRWWDGLSGLFAGIPTAAPASVTVYGTSGKLAEGAAYGRTGLDALVQALQAKNVSYEVERHPQYGAFLKAVAGTANGSLGGYDGWLYAVKRQGAWLTGLLGLGSFVPQSGDQIVVYYGNSTALIHSVKWEPAVPREGQSVTVTIEQETYDWDAGKAVVAPAEAARVSVGGKSALTDKDGKATLTAGKAGSYTLSMDGYQTGKAPTYVTTEVPFWIDTYNKTVKLRVEGDQGVLAEGTASGGTGLEALESFLKAKKVDYVVKEASFGKYITSIKGIENAKFGGYDGWSFAVKKGNNWIIPAVGLDAFALEDGQEVVVYYGDNTKLAESVVVTPSAPKPGEAFSIQVTSREMDWETGKLKAAAPVAGVQVKVGAATATTDGTGAAKFAGVKEGLHDITISGYAEGKAPAIVRSVQKLAVASAYSDQSAVSKWALDSVRLTKAAGVLLGSNDNAAAAFQPKASVTRAEFVSALVRSIGLKPASGSTFKDVKATAWYAKELEAAAQAGLVAGVAPGTFAPDAKLTREQAAQLLTRALKLQAKASVALADSAQISAGAVSSVQAVVGRGIMIGDERGRFLPKQTLTREQAAVIAQVVLNEPGVGIWSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJM0</accession>
    <name>A0A398CJM0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding S4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01369">
        <property type="protein sequence ID" value="RIE01369"/>
        <property type="gene ID" value="D3H35_23655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025490">
        <property type="entry name" value="RNAbp_HP1423"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038881">
        <property type="entry name" value="RNAbp_HP1423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="95" mass="10870" checksum="4399E177B095BD2A" modified="2018-12-05" version="1">MRLDKFLKVSRLIKRRTVAKDVSDQGRVLLNGKEAKPGSVVKPGDTLEVQFGQRILTVRIERLAESARKEDAEELYTIVKEEIRKREDSADFLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJR5</accession>
    <name>A0A398CJR5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02943">
        <property type="protein sequence ID" value="RIE02943"/>
        <property type="gene ID" value="D3H35_20265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="927" mass="99118" checksum="F0E61EC606D86579" modified="2018-12-05" version="1">MGQAGEEPAEIDWLDIPASGEIATFNHVQEDGVFQLYAKAIDKAGNVTVARMDNAVTVNSAVNVSAAFHPGTDGSYMKSPVVYFGIQGIGVESVKYAVTGSSAAPAQYSSVAEAVYEAVLGLENGEVYVIPANTALNGTYVVHVKVKEAAANRYYTYSKLYSADNAAPKVTFSPGGVSYPLERHNVKAAVSDSLSGVALKQYQWLKSGEPAPVKESAGWAELPEDGAVSIDNNGLSPGEIADYVLYVVGEDAAGNSVVASTGIFKVTRKAEAEAPAAADSELLYVYGDSGDGYTAVVRLNLENAIKEGYRYSLSSDGGSTWSRWLPYSSFAEVGGLTDDNPATIGIKAKFRSPDGKESEPVGLRTDSASTDEPVYGIPSHNTLRPVKSDDFVLSIKVPTGVRAVPSVGLNPAEPARIRGNQFRVTKNGVYSFDLTDLSDDTRSAVLLVVVDNMDDIAPEGTVEYSMLSPTNSNVQARLVTSSEPVRVLNNSGRSVYTFAENGTFTFRFEDEAGNTASVVAEVDNIDRTPPAARIVRSYAYGENGSRTFATLRDGDDNVVLAQGVVLHVEKANPLDEDFKIVSGTNGGIVRTNGEVHFTVVDAAGNTAVLTEDIADLAPFLSDPDSVTYEFVDENGVPLPEDRIAVIDGVKVAKGKVKVTVSGTVLAPNRAFLGTAPASNGNGGYSNLISDENGSYSYSRTYSANGQTYLAISDLLGNVNKVPIVVRGLDNTAPVIKLNRPIASVTRNKADFNALTDLGGYVVSDNASKPANLVVEASSLNLSQVGTQTVVYTVRDEAGNTSTIQQKVYVLPEDGMMIVGNGLLLSAAQSEKVLFDTNIVTFDISRYNLMDVGGTTMENEWGTYDIYYQSGLYREGQMKYIAQGISMSELLNRTFTVQFPATGWYTVIVRTQEREREFTTFFIANMGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK10</accession>
    <name>A0A398CK10_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Esterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00217">
        <property type="protein sequence ID" value="RIE00217"/>
        <property type="gene ID" value="D3H35_29730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="453" mass="50886" checksum="DE48585F65665C70" modified="2018-12-05" version="1">MKRRVDMESKIITLSNVYSKNLNNVRDIFVYLPPSYDISITDRYPVLYAHDGQHIFAADHKGGSWNVHATVDRLSRESLMREIIVVAVSSISDQRVSEYFHDNPGVSETFHAKCSGEVYERFLVEEVKPLIDNTFRTLPDRDNTAIIGSSAGGLVSYHIGFRRPDVFGHVGILSPFFVHTVVKEAESALEQNEDPISKLPIYEKFSTKPPIRIWLDIGGAEGLLMVEDVREAADRLVDQGFKPGNDLMFLLDPEAGHTQQDWANRMASPLLYFFGRIGKPASLEMLGRRKIGLNGRSACLYPNVTYDSGFRTSLLEAEYSVDRPEILSIASDGRVTPLSIGEAKITVRFGGLEHSVGIEVVQELSDRVEIEFSVEVPPSTPVNAPIHAGLEIPKKKDGLYQGRFQLPRDLIFDVKVSRGFGFHEKRGSSRRFSTSESQSLHFVVEEWEPDELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK96</accession>
    <name>A0A398CK96_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02572">
        <property type="protein sequence ID" value="RIE02572"/>
        <property type="gene ID" value="D3H35_17970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="133" mass="14873" checksum="63B627D7896D058F" modified="2018-12-05" version="1">MGLFGLFKKDNNSFLQTALYHLEGLPIAEKVLCTITLMPTELQISGGGTSFAIDLNQIRNAEFKTDRQPAPSGGIWATSYMLINYINLENYLLSVTFKLDIAEGKAKQIKNALKIVDELNLRSQNRPNIKVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKA0</accession>
    <name>A0A398CKA0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_19305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic sulfate-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02785">
        <property type="protein sequence ID" value="RIE02785"/>
        <property type="gene ID" value="D3H35_19305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901681">
        <property type="term" value="F:sulfur compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902358">
        <property type="term" value="P:sulfate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01005">
        <property type="entry name" value="PBP2_CysP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034408">
        <property type="entry name" value="Sulphate/thiosulphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005669">
        <property type="entry name" value="Thiosulph/SO4-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30368">
        <property type="entry name" value="PTHR30368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00971">
        <property type="entry name" value="3a0106s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00757">
        <property type="entry name" value="PROK_SULFATE_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0574">Periplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017410028" evidence="7">
        <location>
            <begin position="32"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="365" mass="40295" checksum="07836DD51AD66A35" modified="2018-12-05" version="1">MKSFKRIHYVLISVLLITVLAACGSNNNANPSSSESPKASPSASPSASTPAKTPDPVELLNVSYDPTRELYEEYNKSFAEYWKQETGGTVTIKQSHGGSGKQGRAVIDGLEADVVTLALGYDIDAIAEKGLLKTDWQKSFEQNSTPYTSTIVFLVRKGNPKGIKDWDDLVKDKISVITPNPKTSGGARWNYLAAWGYASKKFNNDQAQVEDFMKKLFKNVPVLDSGARGSTTTFVERGIGDVLLAWENEAYLALKEYGDKFEIVTPSLSILAEPPVAVVDKVVDKKGTREVAEAYLKYLYTEQGQEIAAKNFYRPRLQSVADKYKDQFPQLNLLTIDNDFGGWADTQKKHFADGGLFDQIYTPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKN4</accession>
    <name>A0A398CKN4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="2">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sucD</name>
        <name evidence="7" type="ORF">D3H35_11315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03273">
        <property type="protein sequence ID" value="RIE03273"/>
        <property type="gene ID" value="D3H35_11315"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="105"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2 3">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="308" mass="31655" checksum="F8653C3C09EA9F86" modified="2018-12-05" version="1">MSILIDKNTKVITQGITGATGLFHAKGALDYGTQMVGGTTPGKGGQTVDITLENGSTVSLPIFNTVKEAVAATGATASVIYVAPPFAADAIMEAVDAELDLAICITEGIPVIDMIKVTRYMEGKKTRLIGPNCPGVITPGEIKIGIMPGYIHKKGHVGVVSRSGTLTYEAVHQLTSSGIGQSSAVGIGGDPVKGSEFIDILKLFNEDPDTYAVIMIGEIGGTAEEEAAEWIKANMTKPVVGFIGGATAPAGKRMGHAGAIISGGKGTAAEKIAKLNECGIKVAPTPSEMGSTLVSVLEERGLLEKCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKQ6</accession>
    <name>A0A398CKQ6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar motor switch protein FliM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">fliM</name>
        <name evidence="11" type="ORF">D3H35_11425</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03293">
        <property type="protein sequence ID" value="RIE03293"/>
        <property type="gene ID" value="D3H35_11425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17908">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001689">
        <property type="entry name" value="Flag_FliM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02154">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002888">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00955">
        <property type="entry name" value="FLGMOTORFLIM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01397">
        <property type="entry name" value="fliM_switch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="11" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="11" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliMN_C" evidence="10">
        <location>
            <begin position="253"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE03293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="333" mass="37553" checksum="8E606C494E6771DF" modified="2018-12-05" version="1">MVDVLSQNEIDALLAALSSGEMDAEELKKEDTQKKVRAYDFKRATRFSKDHIRSLTRIHENFARYLTTYFSAQLRTFVQINVVQVEQLPYDEFIRSIPKMTILNIFEAEPLEGRMVMEVHPNVGFAMLDRLLGGAGAAPTKIGSLTEIETIIMEKIFSRAFESLQEAWKTVIDLQPRLEALETNPQFMQIVSPNETIALISLSTKIGDTTGMINLCIPHVVLEPIMPRLAVHQWFASQKKSRAPEEQEALERRVNKAKLPVIAELGSSWISVSEFLNLQVGDVLALHKATDEGLEVKVGDKVKFIASPGTVRDKMAIQIHEIVSEEVEEIHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKU3</accession>
    <name>A0A398CKU3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lytic transglycosylase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_20115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase Slt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02920">
        <property type="protein sequence ID" value="RIE02920"/>
        <property type="gene ID" value="D3H35_20115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008933">
        <property type="term" value="F:lytic transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000189">
        <property type="entry name" value="Transglyc_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00922">
        <property type="entry name" value="TRANSGLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLT" evidence="2">
        <location>
            <begin position="45"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="193" mass="22317" checksum="2629164FE429FB8C" modified="2018-12-05" version="1">MNRINKKIKRKRVLLPLVLLVLGVLFIQSEWLGRMIYPLSYTEEIRSSAKQFGVDPLLVAAVIRVESNFKPEAVSSKGAVGIMQIMPETAKWILKKEHFEGVSIDDVRSEPHAGIQLGTWYIRDLHRQFQGNRIAALAAYNAGPGKVRQWLNEEVWDGSEETLRNIPYGETRHYVQRVMYYYKKYSKLYDSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKW5</accession>
    <name>A0A398CKW5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_19450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02812">
        <property type="protein sequence ID" value="RIE02812"/>
        <property type="gene ID" value="D3H35_19450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="105" mass="11293" checksum="A1B9EB4AA33EB778" modified="2018-12-05" version="1">MILIVRMGLNDLGTKRYWIFGLILVCSLAVDLIIDVLQGIGPYYMQLNMILPFKMMGAIETSIVVSVLIAFVRKPLGKLLAAILTAGTNSSGGGTNPVPPQDSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL61</accession>
    <name>A0A398CL61_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02990">
        <property type="protein sequence ID" value="RIE02990"/>
        <property type="gene ID" value="D3H35_20525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="15"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="309" mass="32777" checksum="C22CD3A393A628C7" modified="2018-12-05" version="1">MADLTMQAIRYHQFGEPEVLLLEPAPRPEPQPGEVLIRVLAAGVLPVDWKIRKGLFPLPVQFPVIPGTAMAGIVEEAGPGVTSFKKGQAVFGRSSKGTYAELTTAPVEAIALKPSSLSFVEAATLSGGASTAWRAIIDGEVKSGDRVLIHGAAGGVGLFAAQFAKWRGAHVIGTAGPANIDFIRSLGVDTAIDYTSVPFEQAAQDVDFVLDTVGGQTLERSWSIVKRGGTLITITGQPPMERGRELGVRVLRSSLASGQNLTEIAALIDEGHVKTYVQSVFPLDQARQAHERSESGHGRGRIVLRVADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL75</accession>
    <name>A0A398CL75_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03413">
        <property type="protein sequence ID" value="RIE03413"/>
        <property type="gene ID" value="D3H35_12160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="138" mass="16516" checksum="9EFF2315FCE823A4" modified="2018-12-05" version="1">MNIEVIYAITERFFLDLLKLYEQEEWTNKRNPAGIKKMMEHCTIIGLVDKDNDKLVGFLRVITDFVYRATVYDVIIQSDYQGKGLGRMLMDEVVNHPELKDIERIELYCAPDKIEFYNKWDFYKVSEFTHFMRKTNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLE6</accession>
    <name>A0A398CLE6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LTA synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_20865</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the LTA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03042">
        <property type="protein sequence ID" value="RIE03042"/>
        <property type="gene ID" value="D3H35_20865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012160">
        <property type="entry name" value="LtaS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005091">
        <property type="entry name" value="Mmb_sulf_HI1246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="9">
        <location>
            <begin position="276"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="660" mass="74719" checksum="230AA8AB459EB95B" modified="2018-12-05" version="1">MLTQLQAVAKKGLRLSFDGIRIGSVWGTALLVLSMLFKLEWLDHQLDVGGMNHWKWMVNAGAMLIATCWLALLGPRARAIAITVLDLALTFVIFSDLIYFRYFKDFISIPVLLQAGQVSSLQDSIWSLIYPGDWWLFADIPVAIALTITLLWWMRKNSKASLYYRSKPRKKLWLKGAPALLVLAAGIILISYPVQVQKNGWASGLFVGNWWNVPIYNVTGLFGFHGYDSYRYAKEHWFGDGISKADYEDAKDWFDDRKKLQEQMESEPLYGKYAGKNIILIQAEAFQTFVIGQELGGQEITPNLNRLISQSVYFPNFYHQTGQGRTSDADFITSCSLHPLPTGSVFIRFAGNEFDCLPSILNEAGYDTTVHHAYDGSFWNRNNMYHNMEYAQFYSVKDYTIDEPIGWSLGDKSFFRQTVQQIKERGEKPFYTFAISLSSHHPFKLPTSSTKFNVGEFTGTTFGYYLQAAHYVDEAMGDLIEDLKQNGLWDDTILMFYGDHDNSLYDMKPYEKLLGRSMTDLEKAEAVRRVPFFIHLPGDDQAGTTIDKAVGQQDTAPTLLHLLGIPVKDRYMMGISMLSKAEKPVIFRNGEYTDGKVYYVPGSDGLPEHGECFSVPASEKLEPAVCKAGAEAAKKALAVSDRVVENDLIARFRKDDAEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM15</accession>
    <name>A0A398CM15_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02259">
        <property type="protein sequence ID" value="RIE02259"/>
        <property type="gene ID" value="D3H35_16130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="63" mass="7454" checksum="EDE5670BE2C127A7" modified="2018-12-05" version="1">MYLLTTDMVENYTGVSHKGVLPYRNFLQWPQCSELRFRSFASSFHRSTAENKYFRQKSKTAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMA7</accession>
    <name>A0A398CMA7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTP pyrophosphokinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_10875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03585">
        <property type="protein sequence ID" value="RIE03585"/>
        <property type="gene ID" value="D3H35_10875"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RelA_SpoT" evidence="3">
        <location>
            <begin position="55"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="300" mass="34458" checksum="C358C04BFD5899E3" modified="2018-12-05" version="1">MSTHPIEQIKRFKNDITRFMMMYKFALDQLETKIEILKEEFQYLHDYNPIEHTKSRLKSPESIMNKIGRKGCDFTFPSIKAHIKDIAGLRITCSFISDIYRIFDMLRNQRDLTIVEVKDYIENPKPNGYQSFHMIVEIPVYMSDRQEAVCVEIQIRTIAMDFWASLEHKIFYKYNEAVPARLLRELKEAADSATALDRKMERLHKEIESIKEEQAEDEVESFRRFIIDNQQFSIPGALLEMLGDGLETARIEEAAYEEAADGADASANVVAAAEANIEAVDEAAVAANIEAAAEAAYRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMI8</accession>
    <name>A0A398CMI8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpP</name>
        <name evidence="4" type="ORF">D3H35_26940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00821">
        <property type="protein sequence ID" value="RIE00821"/>
        <property type="gene ID" value="D3H35_26940"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1 2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="90" mass="10222" checksum="FF190C8E8F2F2CD9" modified="2018-12-05" version="1">MTREAVLNQLTTIIHQYLEVEIPETVTEESRLFDDLSIDSIMVLQLIVYIEEEFNVTVPEEDLDPSVFFTLGSLVTFIQQLQAGSGRSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMZ1</accession>
    <name>A0A398CMZ1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable cytosol aminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucine aminopeptidase</fullName>
            <shortName evidence="8">LAP</shortName>
            <ecNumber evidence="8">3.4.11.10</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Leucyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pepA</name>
        <name evidence="10" type="ORF">D3H35_10205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.</text>
            <dbReference type="EC" id="3.4.11.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="8"/>
    <dbReference type="EC" id="3.4.11.10" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03662">
        <property type="protein sequence ID" value="RIE03662"/>
        <property type="gene ID" value="D3H35_10205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="9">
        <location>
            <begin position="358"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="513" mass="53888" checksum="44491CEA7E2E08CA" modified="2018-12-05" version="1">MEWSGWQVEWSVARADVEAARGNGPIAEATIVFASPEDMKGTGVWVHPALDGALRDLFRRGSFGANAGETAMLPSLGLLPEAYVIAAGRGAASFGIRELRLAAGAVGKALAGLKAESATWVIPAALTADAFDGTVPEAASAVAEGLLLASYRRDSRSAEGRKLPSPKLFFDLENGESADAWSRGFERGVKTADAVCYARELTNLPGNRLTPATLAEEAESLAERFGLECRIYDEIEAAAEGMGGLLAVGQGSVNPPRMIVLRHKGAPNSTETIGLIGKGVTFDTGGISLKKPEGMEEMISDMGGAAAVLGVMRAVAERKLAVNVTAVIPAAENMPSGNAFKPGDVIRMYSGQTVEVLNTDAEGRLVLADGLTTAIRAGATRLIDIATLTGAVMVALGDVTTGAVTNDDTWLSQLDLASRRAGEYLWQLPAHPEYRKALRSDVADLKNMGSKWGGAIFGGLFVGAFAEDRPWIHLDIGGTAWMWSDRDLEPAGGTGVMVRTLIEYLESEALAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNA0</accession>
    <name>A0A398CNA0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04836">
        <property type="protein sequence ID" value="RIE04836"/>
        <property type="gene ID" value="D3H35_05055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="189" mass="21728" checksum="3B33E8DA736CEA41" modified="2018-12-05" version="1">MPHLIGDRIVLREYRREDLEPIRAWVNNPEIVCHLSDIFLYPQAMDSTEAYLESMVEGKSDCLGFVIADPADGSYIGQINLDSVDWKNRVGKIGVVIGSVRHLGQGFGTEAMLLLIDFSFREMNLNRLELEVYDFNDRARSCYRKCGFQEEGRLRERQYKNGRYVDVIQMGLLRSEWEAQGRIQGGGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNA3</accession>
    <name>A0A398CNA3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_08375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03965">
        <property type="protein sequence ID" value="RIE03965"/>
        <property type="gene ID" value="D3H35_08375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="55"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="127"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="5">
        <location>
            <begin position="210"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="4">
        <location>
            <begin position="351"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="623" mass="69611" checksum="C45C48F4796F6A45" modified="2018-12-05" version="1">MTRGKDGRQVDEWSDIGLWSAITGSAVLLASIAAYAGWAAGRKRARPSADAPSYHSELLQSLYEDSPVSFAVIDRQGRFLDVNHEPSVLTGYTFSELSGQPFASLVADESYDATLQMFHKTLQGERCTQDIRIIHKDGSPIDLNISTSPLVRKGRTIGILSFVHDDSDRKRTLERIRYMAYYDDMTGLPNRRSFMKRLEDRLAETKASGDIVTVCFLDVDGFKLVNASFGRDFGDMLLLQIAERLTHCFDSPRDLARMEGDEFVGMLVGSREGDGLERLGNSILRAMEEPFELNGLPLHITASIGMAVGDPDDDMSSLMKKADAAMNRVKENGKNDYLLYDSEMGPTALHKLTLQHEMRKALNNGEFLLYYQPKYDLGSGKVVGLEALVRWRHPVRGLVPPGEFIPAAEESGLIVPLGDWVLEEACRQNKAWHDEGMPRIPVSVNLSIRQFAQRDLTGKVADILKNTGLSPQYLELEVTESMTMDVERATRCLVELTNLGVNISVDDFGTGYSSFSYLKNLPISRLKIDRSFVRDIQQDPDDAAIVAAIIAMAHNLQLQVIAEGVETEEQVHFLRRHHCDEMQGYFGSPPLPVGDIRKMLNSAQQSPAAYNSLPMMEHWKETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNK6</accession>
    <name>A0A398CNK6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YneF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_16430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0154 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02308">
        <property type="protein sequence ID" value="RIE02308"/>
        <property type="gene ID" value="D3H35_16430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005359">
        <property type="entry name" value="UPF0154"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03672">
        <property type="entry name" value="UPF0154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="75" mass="8857" checksum="8E4073D51D034103" modified="2018-12-05" version="1">MSTVWQIIIPIVTLLVGVVGGFFFGVYYLRNQMTKMQNDPDMLQKMAKQMGYNMNKQQLQKAQQMMKNQNQKPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNM1</accession>
    <name>A0A398CNM1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxygen sensor histidine kinase NreB</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Nitrogen regulation protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">D3H35_09825</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03840">
        <property type="protein sequence ID" value="RIE03840"/>
        <property type="gene ID" value="D3H35_09825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 18" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017467699" description="Oxygen sensor histidine kinase NreB" evidence="20">
        <location>
            <begin position="35"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="21">
        <location>
            <begin position="437"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="22">
        <location>
            <begin position="708"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="18">
        <location>
            <position position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RIE03840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1070" mass="118582" checksum="CB12546FEB12C489" modified="2018-12-05" version="1">MRSFDFVKGMGRGSLRIVILSLALFSLVPQASSGAAKDNLDYSHILYFFQQGWTVLWGEKTGTPADRWVPLDEREQLKFKGYHGIVWLKRKMPPLPERDPSMLLTYSKSVETYVDDRLLDSFNMEKASRYVNPNMTQRIVSFDPADKGRTLYVKWRWEGAAYWNGWHGIGERTLIDRTIAQSNQQLAAFSIVFSMACIAALFVYWHRREERLYLWFALVTGCAGAGIGLMSSSLSWSRSLPMDPVYYFRDLLLPLGVTGFAGFYGSALRDRYGRAYRWIAAGLFIYTLATAWASLVDSELFRKMTIVYLSYLLTPILLYMSYTLFRYGRERNRPRSGEFRWLLGGYASLTGSAAVHLYLNANPNTYNELYSLPGITGTIIALALPIGLTLFIGCLGMVLLSRFKNVYRRLKQTADELAVANAEMETLGRLKDDFLRNTTHELRTPLHGIAGLSESLMEGASGPVGDRVRRDLKLIRNSADRLLRLVNDILDWNRLKHGDIKLTLGPVNVVQTAEAVAASLAPLAKSKEIAKLAVEAVGEPPAALADSARLEQILYNLLGNAIRYAAPGSIVARIESAEAIGERGSADVRITIEDDGPGIAPERLARLFEPFAAAENHYGGGTGLGLSTSKRLVELHGGSLAIDSSHGLGTKVNFTLPAAAGETTVVDISESVMERLSGLAEQSEEIGTVLPVIPDSLREDKQSEDRPLILIADDEPINLQVLRHFLRGGSYRIAQAKDGAEALDLLENGEKPALLLLDVMMPGMNGYEVCRRTRERWGPGELPVILLSAQNRLRDLKLGFEAGANDYLTKPFTQGELLARTEIQLQLSRLHLSLEELVAKRTEDLEETNRILAGSVRETAEALAEVSVLEERNRIANEMHDVVGHTLTAAIIQVEAAKKWAERDFGKSVERIVVTGDLVRKSLDEVRRTVRMLKDDSIYFNLEDALQELIRETTEHAEVAVAFDPVPLPPLSELSGRVVYHALMEGLTNGIRHGRASRFRFELYPEDGSLLFVLTCDGEPYGNAKPGFGLTSMMERVHLLGGTVTIGNAGNDGPAGCRLFLKLPLVSGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNU0</accession>
    <name>A0A398CNU0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase family sporulation protein PdaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pdaB</name>
        <name evidence="3" type="ORF">D3H35_02435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05026">
        <property type="protein sequence ID" value="RIE05026"/>
        <property type="gene ID" value="D3H35_02435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014132">
        <property type="entry name" value="PdaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02764">
        <property type="entry name" value="spore_ybaN_pdaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="55"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="263" mass="29585" checksum="C1E843DB62763829" modified="2018-12-05" version="1">MNFFIVWNARHIRRLFFLTAAVLLSAGIIWVEKENISVFAPHPPAAVYSVPTERKVVAITFDISWGEKRADPILDILKNKGVQNVTFFLSSPWSKTHPDIVKRIADSGYEIGSHGHKHVNYSQLGDDEIRNQISTAHGVLTEMTGKGPNLIRMPNGDFDKRVLRIAEGLNYKVIQWDTDSLDWKNPGVDNIVQRVVTRAHPGDIILLHASDSCKQTHEALPIIIDQLRAKGYEFVTVSQLLGQAETKGNTVQDRTTWNELPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP79</accession>
    <name>A0A398CP79_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Site-specific integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_01410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05206">
        <property type="protein sequence ID" value="RIE05206"/>
        <property type="gene ID" value="D3H35_01410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="137" mass="15711" checksum="864BB3B15B733845" modified="2018-12-05" version="1">MIRQNNSENKAGAKTKERVVFITPSLSSMIQAYINTERYESGINGTNYLFINLFGNHKGQPFRTRNFLRILKDAGEVSSLPRSEIRTHSGRSTRAQQLVELMEEHPELGITETFIIEELGWSSIKTLKVYRKGYSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPJ3</accession>
    <name>A0A398CPJ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_01180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000011">
        <property type="protein sequence ID" value="RIE05316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05316">
        <property type="protein sequence ID" value="RIE05316"/>
        <property type="gene ID" value="D3H35_01180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="7">
        <location>
            <begin position="128"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="128"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE05316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="223" mass="25782" checksum="D4D4088AF7720B10" modified="2018-12-05" version="1">MRPHIVVIDDDDKITSLLRRSLAFEGYEVTTAHDGADGIRLLGEKNAELIILDVMMPKLDGWEVCRRLREAGISAPVLLLTARDEVQDRVKGLDLGADDYLVKPFALEELMARVRALLRRRPERAEEDGRLRFEDVTLDYDGRETIRDGKRIELTAKEFDLLHLFMQNPKRVLSRDQIMERIWGYDYSGESNVLEVYVAMLRQKMEEHGGKRIIQTVRERGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPK2</accession>
    <name>A0A398CPK2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_06885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04322">
        <property type="protein sequence ID" value="RIE04322"/>
        <property type="gene ID" value="D3H35_06885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="614" mass="70399" checksum="9C4C93C1C969C0D6" modified="2018-12-05" version="1">MPGDKRERQEKKREYVRVDERQRESTLRSIFGDDPRVYIKNLEGVKEVYEGLESSSTFMPDEDQTIALFAILSFNTTLFEGYQLIDKHKEVIDILDTAINSLKVLLDSYDNRGLDSGRSLRRKRITEKGDGLDTSTELSYDKKYQNIVDDVQLQFTDLLFQCLSSTTVPKTIPGTTGITGARDDGKFYISFIRMGQGDCTVFKTPEGEVGIIDCGSNGFSHIGQYRVNNKVSYTEPSDGTPMTLNDHSHFSNYAANKKKRTHTLDVTKEESSAECRKKLKEILKRPEYLGTNYVLNYLILTHKDEDHCNEFKEIINEFLLTNVFHSDDLQKYPIDKKIKNNGKNNFNVRVNKDESAVYIKTKDSKKPFTQVLDEGIGSTLVLSDYDWNKAVANPEKESSEKRRTTLPPLNEKNPIKSKIRIVASDVKKGDTNASSVVTLIELFRSEEDCQKYSPPNDPGGKTVGKEFEEDFDNCQMYKPFLKVIICGDATFETEDFMIERYERNKILSDVNIIQVPHHGSRETSSSERFIKMIHKKDEMIAVISAGKHIKAHHHPQAPIIQRYATYTRSKDYPHYSWVWSEDNVESLNLMYHDIYVLGSNGHQHFSIEKEGDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPV2</accession>
    <name>A0A398CPV2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_13795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01857">
        <property type="protein sequence ID" value="RIE01857"/>
        <property type="gene ID" value="D3H35_13795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="220" mass="25630" checksum="B3B3E14F1CC1A8CB" modified="2018-12-05" version="1">MSLEVTFVKMTPWAIPPVKEKLVVHPVPDEDFRWIKQRRVKGACWPYRAAKELGWTIRSPIDVDIEPVSEMQITTEKPEEIAQIQHLSGISYWQQRENIYLGVKPSGWFQLHQFKVRNNWYQMFIPNGEGTFEWRLGWSIKIPNEHVLLFQPLEDTDSSFVVHPGLLTAKGLERFHSGLGLPIAFEPRQTRRIRRNDPLAKLLVLHQSALSLKDTVIEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPX3</accession>
    <name>A0A398CPX3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_06385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04240">
        <property type="protein sequence ID" value="RIE04240"/>
        <property type="gene ID" value="D3H35_06385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="168" mass="18647" checksum="8EFD12EAE426F0B0" modified="2018-12-05" version="1">MERKYGIDMNMPEGKLDGYYAQIVKAIAERVTLFDSHKELIVLDSPDSLPIVEELLNGCKVDHERVELVRLPEYGARPGPLFEDYAIAARSGNVFLDLSQAAFFSLREKKPEAETAPAILQLHEHLIVDTTLGQGLTVFAIDSQLAELAERIAGAYGCEAEWLETDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ06</accession>
    <name>A0A398CQ06_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04270">
        <property type="protein sequence ID" value="RIE04270"/>
        <property type="gene ID" value="D3H35_06545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030436">
        <property type="term" value="P:asexual sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005081">
        <property type="entry name" value="SpoIIGA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03419">
        <property type="entry name" value="Peptidase_U4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="114" mass="12248" checksum="7F4F12B866359A94" modified="2018-12-05" version="1">MEGAASRGLGREAQGRVGGSAYRGNERQAHRTVRMGHRLRLVPYRAVNGNTRMMLAIKPDMIELAREGEPPSRVTRVLIGLDGGTLSSDGTYRAILHPDFALSGEPSPAPSQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ67</accession>
    <name>A0A398CQ67_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">D-alanyl-D-alanine dipeptidase</fullName>
            <shortName evidence="3 4">D-Ala-D-Ala dipeptidase</shortName>
            <ecNumber evidence="3 4">3.4.13.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_12380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>D-alanyl-D-alanine + H2O = 2 D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20661"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="EC" id="3.4.13.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase M15D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.22" evidence="3 4"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03449">
        <property type="protein sequence ID" value="RIE03449"/>
        <property type="gene ID" value="D3H35_12380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01924">
        <property type="entry name" value="A_A_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000755">
        <property type="entry name" value="A_A_dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01427">
        <property type="entry name" value="Peptidase_M15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026671">
        <property type="entry name" value="AA_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 4" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017412947" description="D-alanyl-D-alanine dipeptidase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR026671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="245" mass="27464" checksum="5D2E05C9A2833C35" modified="2018-12-05" version="1">MTHTVRKLALIVIALSLALVVPTVGAQAATSNIKKDTAEKKRELPKGFVYLDEAIPTAIFDIRYYGDNNFVGARIDGYKAPYAILTSKAASSLKSVSDELAKKGYRLKIFDAYRPQKAVDHFIRWSKDAKDTKAKKSYYPNVAKKDLFKLGYLASKSGHSRGSTVDLTLVIAKTGEEADMGGSFDFLDPVSSHGTKKITAKQTANRTLLKKAMEKHGFKSYSKEWWHYTLRSEPYPKTYFNFNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQB0</accession>
    <name>A0A398CQB0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_20350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02958">
        <property type="protein sequence ID" value="RIE02958"/>
        <property type="gene ID" value="D3H35_20350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="192" mass="21440" checksum="2056634F983060FD" modified="2018-12-05" version="1">MNAKRGRPRNVETQKSILSASYDLLLENGFGSVTVEKIAERAGVSKATIYKWWPNKAAVVMDGFLSAAAARLPVPDTGSVFNDILIHAANLARFLTSREGKIIKELIGEGQFDSGLAEAYRTRYFHPRRLEAGQLIERGIQRGELKANLDIELSIDLIYGPIFYRLLVLDDNLDDAYVENLVKYSFAGLNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQE1</accession>
    <name>A0A398CQE1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_20650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03008">
        <property type="protein sequence ID" value="RIE03008"/>
        <property type="gene ID" value="D3H35_20650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="255" mass="29272" checksum="E48ABB059631ACE2" modified="2018-12-05" version="1">MSPSENNGYSAKRYRTPDGAPADIVIFTIVSSPKNTIQKSLPLRELQVMLIQRKAWPFEGMWALPGGFSKETETLRETAMRELEEETGVENVHCQYLNVYSTPGRDPRGWIISHAFFSMVREELLQHRRAATDAADVRLFSVDEALESLELAFDHRDIIRDALDKLKEEVLRTTLAKQFLPDEFTLGELYQVIRTIIPSFQEDNFIRKLKTTRRQGILEPALDAEGAPVYSTQFSQRPAQLFRFTGNEPEWSIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQG9</accession>
    <name>A0A398CQG9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF342 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03509">
        <property type="protein sequence ID" value="RIE03509"/>
        <property type="gene ID" value="D3H35_11515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005646">
        <property type="entry name" value="FapA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38032">
        <property type="entry name" value="PTHR38032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03961">
        <property type="entry name" value="FapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="331"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="458" mass="49840" checksum="0A0DAA5A371173D3" modified="2018-12-05" version="1">MQVTFSDDKMKAYLGFQRVEGVIRITVRELETYLASQGVKHGLQSETLSLVCQKPQDFYFNQTVIAVGTPPVNGVDGFIRGLFEVKEQGRKPVEREDGSIDFKEVTQLANVKSGQLIAERLPPQPGQAGKAVTGEEIAAKDGKEANFKVGKNVVVNPEKTAMYAAIDGLVTKTDKEKLNVFPVYEVNGDVDYNIGNIDFVGTVVVRGNILTGFRVRASGDIRVTGGIEGAEVESDGSIEIAGGIIGSNKGFIKAGRNVKCSFIQEGNVYAGEDVIVSQSIMHSNVRAGHHVFCAGAKGLVVGGLIQAGERVTARMIGNSMSTATSIEVGVQPELRQELNELRALIRQYSESLDKTEKALSLLNQLASTGQLASDKLAMRVKLTSTKRQTLEELQQSKNRILEIEKTLEDTSIARVDAVHTIFGGTKIVIGRYTRFVKDSSQRVSFRFSDGDIVMVPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQU5</accession>
    <name>A0A398CQU5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_05315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04882">
        <property type="protein sequence ID" value="RIE04882"/>
        <property type="gene ID" value="D3H35_05315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="122" mass="13644" checksum="114544BE8B3968EA" modified="2018-12-05" version="1">MIGRVAHPRKIVTNYHSGGKPTDVRTLLKAFASGEKLSSIEKNLSKTGYDAAIALSRTYPGLNMVGADIGLDNHLRPWIIELNTNPDPYIFRHLADKRIARKVLSYARALRRIPPAKSKPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQX4</accession>
    <name>A0A398CQX4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage II sporulation protein M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spoIIM</name>
        <name evidence="2" type="ORF">D3H35_05560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04560">
        <property type="protein sequence ID" value="RIE04560"/>
        <property type="gene ID" value="D3H35_05560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014196">
        <property type="entry name" value="SpoIIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038973">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02831">
        <property type="entry name" value="spo_II_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="208" mass="23175" checksum="93504213C067CD94" modified="2018-12-05" version="1">MNIRIWNLSTRDNLNLYVFVGVLFAVGAVFGALLVNALTFEQQQELADRLLAYMNDVRHPNDLNNAAAFWDSFFFYGKWLGLIWLLGLSVIGLPAVLALDFLKGVLIGFAVGMLVRQWAWKGLIFSLATVAPQNALVVPALLIASVSAARFAYFVVRERLFRRKGQLLPPFLAHTAVAFLMLLMLVCASLYEAYVSPLLLERLVPSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQX8</accession>
    <name>A0A398CQX8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02227">
        <property type="protein sequence ID" value="RIE02227"/>
        <property type="gene ID" value="D3H35_15945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="62" mass="7428" checksum="05EF3D73508532BD" modified="2018-12-05" version="1">MAKRSHNEVQESLRELTRIFRPKDPRKFVKDYIRKYRITGGYEDELTTLVEREMVKLNSPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR80</accession>
    <name>A0A398CR80_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_02530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05032">
        <property type="protein sequence ID" value="RIE05032"/>
        <property type="gene ID" value="D3H35_02530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017242790" evidence="4">
        <location>
            <begin position="42"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="5">
        <location>
            <begin position="106"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE05032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="546" mass="60094" checksum="75ABD912D5F9DE68" modified="2018-12-05" version="1">MEREIHMNRNSKKSFGYLLTAMLAFAVIVSGCSSNNGNNAASSPAASSGAPSASNTDGGEKTVDTLRYPLTLTFASLDPHLVPTGGVANIDRHIYEQLVAFNTKYEPKPVLATEIQVSEDGKTYTFPLRKGVKFHNGKELKAEDVVASLNRWKEKTARVQTSFGDSLFKAVDEYTVAITLAQPSNDVPLQLASYLQFSAITTKEAIESAGPDGLTEIIGTGPYKYVEYKQDQYVHLTRFDDYVSPEGPQDGVIGKKEALVKDIYFDLIPDGSTAFNAFLAGDYDFASVSVDNLPQVQSLSDVKLNKVFAGELNIVFNKKAPFPSNLKFREAIAAALDAEQVLEGYTSDPELYRLNSSLVTPDNAEWYSKAGSEKYNQKNPELAKQLLKEAGYNGEELVFLTTRDSAGAFYNATVLVVDQLQKIGIKAKIDTYDFTTMIARRGDPAAWDIYVGSFSNQASPSQVLFLGKSYGWPEDEQLQQLIRNTTTALTPEAKKAASDALHAYHWNYLGAVKIGDTGTYYANRNNVVGYQFFEGPILWNTKVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRN1</accession>
    <name>A0A398CRN1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RDD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_01560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05235">
        <property type="protein sequence ID" value="RIE05235"/>
        <property type="gene ID" value="D3H35_01560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="20"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="257" mass="29134" checksum="BE3B0EB2B4DA4CD6" modified="2018-12-05" version="1">MPKITSSKKSENRGTNMKRASTISRIIASVIDIYLTIFIVLILIFLLLKWFEDDFVISIFLTLFLISVGMITVLFKDVVDGRSVGKRIFNLGVRELNGSVPSTGKLINRNFSSLFWPKDLYNLLFSNDKRKQGDIRNGTEVYQLENTKSMTKIVMKIVISISVIIVFLVFGIITMIKQDASYKEAIIYIKNNKEIQDKVGSNVDIGFFPSGSISRTNGYGEASFNIKVSGDKNNSLSVYIILVKEPNEKWKVKEINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRN8</accession>
    <name>A0A398CRN8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05245">
        <property type="protein sequence ID" value="RIE05245"/>
        <property type="gene ID" value="D3H35_01615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="117" mass="12703" checksum="9FE9AFB1926D34D9" modified="2018-12-05" version="1">MSRVIAFEISSQDAEKQSKFYADVFGWELGQPNWGYYPAKTGSAAEPGIDGGIAQGPSHFPVGVRLQIQVDSIDESIAKAVEHGATVVQEKMDFGDFALAYIVDPLGVHYGLIENKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRQ2</accession>
    <name>A0A398CRQ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05265">
        <property type="protein sequence ID" value="RIE05265"/>
        <property type="gene ID" value="D3H35_01720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="82" mass="9388" checksum="B659D47EF3941EA1" modified="2018-12-05" version="1">MANMKYELIAEIENQIFYIASFNHMGNTLCESFEIRNEEGTILNSGCVAFGIDRWAYALLLKHGTDLEEWPPGLKQLFFPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS08</accession>
    <name>A0A398CS08_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02151">
        <property type="protein sequence ID" value="RIE02151"/>
        <property type="gene ID" value="D3H35_15495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="142" mass="15291" checksum="FA55FCE857EDDD7F" modified="2018-12-05" version="1">MKISSRFSVAAHILSLLATSRPEDCTSEFMAGSVNTNPVVIRRIMGMLRKAGLIHVRHGVGGASLLKGLDEISLLDVYRAVNSVGEGELFHIHDKPNPNCPVGSRIQGVLELVLSRAQEAMESVLSDITMEEVVNALNLKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSC7</accession>
    <name>A0A398CSC7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RES domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05110">
        <property type="protein sequence ID" value="RIE05110"/>
        <property type="gene ID" value="D3H35_02995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014914">
        <property type="entry name" value="RES_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08808">
        <property type="entry name" value="RES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RES" evidence="1">
        <location>
            <begin position="27"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="200" mass="22688" checksum="F5D36BF073BB8F0C" modified="2018-12-05" version="1">MFAAIQRQFEEGSYYSLAAGSELFRGRARNKDGAEFSAHDFWAPPDGAASHGRYNSIGVSVLYCCSDKQSVPYEIHPSHEQAIDIATITANRELKLFDIDKAFEGFEGFVGSGNEETKLIKRHYLLTNFVGACCERIGYDGIKYDGVARRDAHYVNFAFFHSKDDRKLSIVQTAPYFFEIVYKNPLSEWLRDNLESNARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSD7</accession>
    <name>A0A398CSD7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000003">
        <property type="protein sequence ID" value="RIE05463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05463">
        <property type="protein sequence ID" value="RIE05463"/>
        <property type="gene ID" value="D3H35_00235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="238" mass="26571" checksum="0A69C0D7ED16EA6B" modified="2018-12-05" version="1">METRVRSLKPVKEASIVKHFPGKLTVKLQEFEEVATELGADGKVQAVLANGLVLPSKQGALPDKPILTGWKTGRELSGAVPDTEPASGSLADGFIRNQARSFQILSRPDQAVYRSRFEVVTTVGKLSEKIIFLSDIVENREPGRIVLLEATPIFRIRHADRTGRIRNLDPTRRLSIRRIRKIGLRAERCVQARGFHDIAQKNNFFGQLAYSRYNLEARSGIQLDPVGIRFGRIGLDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSE9</accession>
    <name>A0A398CSE9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_13905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01874">
        <property type="protein sequence ID" value="RIE01874"/>
        <property type="gene ID" value="D3H35_13905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="71" mass="8322" checksum="B2FD5078CC58FFBB" modified="2018-12-05" version="1">MIHIKPLFKLLLILFPPYFGINMLLHDTKQIFKRQYKDIDLVINQRTMPNIVIGQAKTGVCKHANDRCQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSF6</accession>
    <name>A0A398CSF6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_18945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02727">
        <property type="protein sequence ID" value="RIE02727"/>
        <property type="gene ID" value="D3H35_18945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="345" mass="38581" checksum="1416AA661F9B637D" modified="2018-12-05" version="1">MRFGVIQISTIKDVALLAGVSPATVSRVITNKGNIASDTRAKVYSAMEQINYVPIQSLAQSKSGTIGFSIARDPKDMLGNPFFNDVLCGIAEEAKKFEYHVQFSLYSSIEEQIENTIKLFKLKQVNGFIFTSVLSSDKDLLLKSMQEKDVPFVMIGSSLNHNVFSVHNDNIRDSYTATKFLLGKGYRDILFLTPNLKQDVMYDRLHGYKRAIEESGEEASAHVVYSSNEEVDITKALDKVMEEGVRFDAILTMESIMSLIAMKYCQRKNLRVPEDVGILSFNNATYLDKVSPSITGLNLNPSMLGAEAFRIVYDLIETKPQSLVQKSVTLPSEIIERQSTQRTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSG1</accession>
    <name>A0A398CSG1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">infC</name>
        <name evidence="8" type="ORF">D3H35_10285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the IF-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03678">
        <property type="protein sequence ID" value="RIE03678"/>
        <property type="gene ID" value="D3H35_10285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019813">
        <property type="entry name" value="Translation_initiation_fac3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00938">
        <property type="entry name" value="IF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="7">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="6">
        <location>
            <begin position="77"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="164" mass="18939" checksum="FCDEEBEECDF4E53B" modified="2018-12-05" version="1">MNEEIRAKEVRLVGAAGEQIGIKPFREAMQMAIDANLDLVNVAPQAKPPVCRIMDYGKFRYEQQKKEKEARKNQKIVDLKEVWFRSNIEEHDYQTKFRNVVKFLGEGDKVKCSVRFRGREIAHSNIGLKILERVAKEVADICVVERMPKLEGRSMIMILAPKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSK0</accession>
    <name>A0A398CSK0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YtkA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_14210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01924">
        <property type="protein sequence ID" value="RIE01924"/>
        <property type="gene ID" value="D3H35_14210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032693">
        <property type="entry name" value="YtkA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13115">
        <property type="entry name" value="YtkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017204369" description="YtkA domain-containing protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="YtkA" evidence="2">
        <location>
            <begin position="51"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="147" mass="15636" checksum="A182EA2C65F6C26B" modified="2018-12-05" version="1">MRLKLRKRLIGVTAPLLLAAGLLLAAGCSDRSAASPAAATEAGSEERIGIEFSASPEKPKVNEKASLKAEVTRGSSPLSEAQVVFEIWPKGAGPESHAQLLAKPGESKGSYELKGEFAEKGTYYVITHITPEDTGQMTMASFEFEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSS3</accession>
    <name>A0A398CSS3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_09655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03808">
        <property type="protein sequence ID" value="RIE03808"/>
        <property type="gene ID" value="D3H35_09655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="186"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="397"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="586"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="780" mass="86688" checksum="B74AD9BC429FF812" modified="2018-12-05" version="1">MRIGFYNHTSVVSGAEISMLLTAKNLKNAEPVVFAPEGELGDRARVSGVAFEPISGYRARLTKNPFVLVRHLAGMAAEGWRLAKRFKSAEVDIVHANSIRAGLIVSLFGWLHRRPIVWHIRDNPPGGWIGRAIDFIAKRTVKELICISESVKAGMGEELRTLAKVVHNGVELSFATAEEKAKYRRAIREELGASPSARVIAVIGQIAPWKRQMDALIAARLLLDDGCDIQVWIVGEPKFREENEAYAERLRQMASGKEWQGKVVFTGFREDVKEICCAADLLFLCSDNEPFGRVLIESMAQGTPVVATRAGGVPEIVVDGSCGLLYEVGDTEGLARCAGRLLGDEELRASMGREAVLRVKQCFGIDRTAEKVEEAYRRILPEKPFKTAIVHDYLNQMGGAERVVASLRRMFPDAPIYTTIVDRPALLEELKDADIRTTWMQRIPGVLKRFKLYFWLFPFAVRSMDFREYDLIVSSSSAYAKGIKKPRGAVHVCYCHTPMRFAWDFEGYVQGMKIPFLLKWASRLFIVPLRRWDARNSARVDEIVANSTIVKERIRNHYGKDASIVYPPVQLERFGPVEADGGRGPDDYFLVVSRLVSYKKIELAVKACTLLSERLIVVGDGPDRQRLERMAGPTVSFAGRLPDDQVERLMRGCRALLFPGIEDFGITPLEANACGRPVIAFGAGGALDTVDPGLNGLFFDSQTPESLAGTLRRFALHEWNPALIRRHAESFGERRFETELRSLIGSALQARGKRLFAASTAAPATGASMTANTTTKEVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSV2</accession>
    <name>A0A398CSV2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SRPBCC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05240">
        <property type="protein sequence ID" value="RIE05240"/>
        <property type="gene ID" value="D3H35_01585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="132" mass="14939" checksum="2A0307117EC9031F" modified="2018-12-05" version="1">MSLALALDFQYKTSIEKLWSALTDSNTLAKWVLPNDFKPVVGQRFQFRAEPTEWWDGLIEGEVLIVDAPNRLSYTWASGGEQHTVVWTLQDLGEGKVNLHLDQTGFANEQGLNGAKYGWSKWQGELEKLLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT70</accession>
    <name>A0A398CT70_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02511">
        <property type="protein sequence ID" value="RIE02511"/>
        <property type="gene ID" value="D3H35_17630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="285" mass="32548" checksum="80368B9FFFA9E60A" modified="2018-12-05" version="1">MAGTGAQQWDTVPFFRRLAGAGAQQWDGVPFFRRLAGTGAQQWDTVPFFRRLAGAGAQQWDTVPFFRRLAGTSAQQWDEVPFFRRLAGTSAQQWDEVPFFRRLAGAGAQQWDTVPFFQRMTGTGAQQWDEVPFFRRLAGTGAQQRDEVPFFRRLAGTSAQQWDKVTFFRRLAEANAQQWDEVPFFRRLAGTGAQQWDEVPFFRPLASVEAQQWDGAPFFRRLAGAGAQQWDEVPFFRRLAGAGAQQWDEVPFFRRLAGTGAQQWDEVPFFRPLASVEVQQRDGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT88</accession>
    <name>A0A398CT88_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipolytic enzyme, G-D-S-L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03978">
        <property type="protein sequence ID" value="RIE03978"/>
        <property type="gene ID" value="D3H35_08445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="10"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="216" mass="23543" checksum="9FD242410769B529" modified="2018-12-05" version="1">MTGRRKTIVCFGDSNTWGYDAKTDARFDEETRWTGRLARLLGDGYRVVEEGLSGRTSVCEDPLFEGLRGLDYIYPCLLSHSPIDLVVIMLGTNDTKERFGLTSFNIAQGITRLSNKAKGTPAGNGGVAPDVLVVAPPVIGKAYADTPIGAPMGARCDEKSFELPVHLEALLKETGIRFADSNEAAAMGETDHMHLDAEGHGKMAEFMHKHISRIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTK8</accession>
    <name>A0A398CTK8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_03695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04609">
        <property type="protein sequence ID" value="RIE04609"/>
        <property type="gene ID" value="D3H35_03695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="250" mass="27621" checksum="8F68B766770272D9" modified="2018-12-05" version="1">MERLQKILANAGVASRRKCEELIAAGKVTVNDKVVSELGAKADPASDVIAVNGKPIKQEKKLYILFNKPKGVITSATDPKGRTVVTDFMREVKERVYPVGRLDYDTEGLLLLTNDGDLAHILTHPKHHVPKTYLATVERVPHGSKLEKLQKGVKLDDGMTAPAEAEYHDIDPEGKYATISITIREGRNRQVRRMFEAIGHPVTRLKRVSFGGIALGSLQRGKHRSLTAEEIQKLRDAADGASREETNISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTL4</accession>
    <name>A0A398CTL4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_08845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04048">
        <property type="protein sequence ID" value="RIE04048"/>
        <property type="gene ID" value="D3H35_08845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017272299" evidence="3">
        <location>
            <begin position="32"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="4">
        <location>
            <begin position="100"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="559" mass="61381" checksum="6D13A51652AD0780" modified="2018-12-05" version="1">MFSRSKSIFVTLVICILLSAALSACSSDNSADSNASSSVPPASSAASAVPTAGNAVSELKIAVPGDAGPLNIYTSAASLDYLVELVFDKLYAPSPYVDQPQPWLAESAEQLDEFNWLVKIRSGIKWHDGEAFSAEDVKFTFEYYRDGPANRYTHHVNDTPNIKTITLEDASTVKFTCATACPTLVNVTLADLPILPEHIWKNVENPRKFTELAIGTGPYKLTEYKPEQYYKFEANKDYFMGAPTVATLNVPIIKDPTAIFNALRAGEVDVVTRSVPAELQDTFAGLPGMKIGETSPLTIVDMRVNYDKEPFSTPAFRRALALAVDRQAIVDTVLLGKARAGVKGYPHPDSPWTNPELSTPFDVAEANRILEQSKYVDGNGDGIRETTDGKALSFSLKVASTEPTHIRAAELLKKQFAAAGIEIKVEVLDAGTIGTLMQTREFDMFIAEIVPHGVADPDQFVQSHKSSYLWTKGVAYPEMDSIIAEWEAESDLAKRKQIAFKMQTLFNNQPTSIALYYPEGRYAYKADKYDNWVKLPGYGIVNKFSFLSAEARKTALGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTP1</accession>
    <name>A0A398CTP1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3055 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04078">
        <property type="protein sequence ID" value="RIE04078"/>
        <property type="gene ID" value="D3H35_09040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021415">
        <property type="entry name" value="DUF3055"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11256">
        <property type="entry name" value="DUF3055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="98" mass="11022" checksum="25FEC6E3ED39CA8C" modified="2018-12-05" version="1">MILKDFDFLSDSTEQTSTRYVTFITPGMHRFDLAILTTNRFYGKKLVVDMQSGRSGVLGPDDLEEEGVLESIYKIDEEAASELAQFLYLVLGAVTFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTW1</accession>
    <name>A0A398CTW1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="8">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ctaB</name>
        <name evidence="9" type="ORF">D3H35_19095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with CtaA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02751">
        <property type="protein sequence ID" value="RIE02751"/>
        <property type="gene ID" value="D3H35_19095"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PTHR43448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="295" mass="33377" checksum="27DD7992A5580AF8" modified="2018-12-05" version="1">MCKTRRRTNSVLKDLVALTKPRIIRLNLIAAFGGFWVASKWDIDWVTLVWMLLGSALTMASSCVFNNYWDRDFDLKMARTRNRALPQGRMKPGFVLGYAIVLGIAGLAVLFGLVNALSGWLGLLGMFVYIVVYTMWLKRTSTWSTSVGGISGAMPPVIGYCAVTGEVDAGAWILFALLFLWQPAHFWSLAIRRREEYKEAGFPLLPVVKGVTRTKWQMLPYIVLLIPAAILMYRYDYVGAFFLWFSVILGLVWLVHAVSGLRAKDDEKWAKADFFLSINYLMVMFLTMILDTNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU00</accession>
    <name>A0A398CU00_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_04510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04749">
        <property type="protein sequence ID" value="RIE04749"/>
        <property type="gene ID" value="D3H35_04510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017312395" evidence="3">
        <location>
            <begin position="26"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="146" mass="15704" checksum="79AA8475566DB772" modified="2018-12-05" version="1">MWKKALLVFSLFAFVATVTVPFADYADAKPRSFSSGKKSFSKTPAQSQSNVNKSDSTTSSKASSTAGTTANRGFFSGGGLMKGLMIGGLAGMLFGGLFGGMGALGNILGLMINVIALFALFMVFRMVYDAYKRRRDRNNPHTNNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUI7</accession>
    <name>A0A398CUI7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02654">
        <property type="protein sequence ID" value="RIE02654"/>
        <property type="gene ID" value="D3H35_18420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="70" mass="8035" checksum="93EC2ACAD7425F5C" modified="2018-12-05" version="1">MTAEQELAYNESAQKKEEVAYRRANHVLYLQRLSKGLKPDNSPSTDGEKTGALQQLLKLEPEFRRLGFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUM0</accession>
    <name>A0A398CUM0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_10995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03557">
        <property type="protein sequence ID" value="RIE03557"/>
        <property type="gene ID" value="D3H35_10995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017223857" evidence="2">
        <location>
            <begin position="28"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="205"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="495" mass="53623" checksum="5A4971204228BB99" modified="2018-12-05" version="1">MVNNRFVKALLCTLIACLIFTAGSVMAEPGQEQGQAGSPVVEASINHNQPSATRYEVQDGKISKEYTDYKDGSKEITSYVYLPDGSVVKSTETIASDQPAVPDNGVTMQGEPQDVYIYDQSIKDKISAVSTAYDLAESEYQRGVRTLAEKNAIQNELHFQADLARADYIIMNPNSAYAKIKLGGSSKSFPLSRNLSYNASSPMTGLDVLVIQRALQLNDLIELPDNLNYGVYGPEVEDAVRTYQSLSGNTPDGIVGSQTYASIFATTSNGVRNLWNLNQINIFRLKHALVQQASVYQIQANAGMPPCNSDKTSGICKEIYVPNGGRLGGAGYADIVDTNRRYVWEVKPDNGRWDENSSINRGGAAQLEKYIIASGNTQRSYFPLITGYAIAPFSVNWSATEYISVRAGRTVGPKAQFQSGMIYYKTNVKTKRQPVTAPSPKESRQKQTAPDAQTLAVSAGAVAAGYGAYRVGKFIIGVLLIPETGPLGVAIILAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUP3</accession>
    <name>A0A398CUP3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_18875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02714">
        <property type="protein sequence ID" value="RIE02714"/>
        <property type="gene ID" value="D3H35_18875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004761">
        <property type="entry name" value="Spore_GerAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34975">
        <property type="entry name" value="PTHR34975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03845">
        <property type="entry name" value="Spore_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="241" mass="26309" checksum="559D9B18AF4919B0" modified="2018-12-05" version="1">MIDKGKISSLQLAVLMYPLILATSVLSVPSVTMRFAGHDMWMSPLWAIFIGLLAIYIAYRLNVRYPSLSPIQSSVLIAGKIPGKLCGLYFLLYMPHLNGVVVREYGEFVLSTILPGTPLYVVMGSLLFVCAINARSGIEVIGRSGIILVALTVIFLFVILLLLIPELYPDELLPIAEKGLKPSLLGAIAPASWLSEFAFLAFLLPFVSDRSRALKASVYSLIAITITMLAVNIVCLFLFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVH6</accession>
    <name>A0A398CVH6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyl-accepting transducer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_05385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04528">
        <property type="protein sequence ID" value="RIE04528"/>
        <property type="gene ID" value="D3H35_05385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="3">
        <location>
            <begin position="209"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="494" mass="54214" checksum="14A8A71BDBFB90E3" modified="2018-12-05" version="1">MNESTAVLVKRNKLFARILWAMLALGIASDLMIGASFNIIMTLAVVGAVTCAIATIMAYKEIGSGYVMYVVPTIISVVTFLLINGDTDPVPGTYFLVYMNLAVMTLYMNYRPILFSGLQGILITTYFYSDPFFREHVFPRQDLSYLYLYLILVIAALFFSTRFAEQLQQSVLKNEKLALQAKEKTEALLHNIGDSIGTLQEVSGRLKSNMTGTEAISREMTQSFGEIAATIESQTSTIESINDSIQSVDEVVTDVYAGYDKLQHKANRTSELTDSSKSDMHSLSEEMKRMDDMMAGTVKLMGELTEQNRHIGTIVSTIGDISNQTNLLALNASIEAARAGEHGKGFAVVSGEVRKLAEHAKQATEAISRILGSINVKVKELALQIDAGQATVSSGIGMTHHLARTLAVIGENNVIVSEQSEFVRASVDRLRSEYAHIADEVMMIASQTRQNLSSVAEVSASLGNQDSHIRDIVGHYERLDLLIGELNKLRKESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVK5</accession>
    <name>A0A398CVK5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_05625</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04568">
        <property type="protein sequence ID" value="RIE04568"/>
        <property type="gene ID" value="D3H35_05625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="144"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="452" mass="47969" checksum="5062EF2B894D658E" modified="2018-12-05" version="1">MAKVIQEIIMPQLAESLVSATIDKWLKQPGDSVDMYEPICELITDKVNAELPSTVRGTLVKILAGNGETIEVGKPIALVETEASADASAGAGASNEAAASVPGAASSGALSATAAASTAAASVRPGTAASPPPAFDPNAPMRGRFSPAVQRLASEHGIDLARLPGSGMGGRITRKDVLDAAANGLPVAAPAAPAQPAASAAVVASPPPLPSIEVEGTNSPDREYYIDVTPIRNTIAKNMRQSVNEIPHAWTMVEVDLTNLVQLRTKLKDEFKREEGINLTYMPFLLKAVVGALKEFPIMNSVWAVDKIIVKRDINLSLAVGTEGSVLTPVIRHADQKNIVGLAHEINDLARRTREGKLKLGDLQGGTFTVNNTGTFGSVLSYPIINYPQAAILTFESIVKRPVVIGDMIGIRSMVNLCLSFDHRILDGVICGKFHQRIKENLESYDADTKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWZ2</accession>
    <name>A0A398CWZ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_02915</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05098">
        <property type="protein sequence ID" value="RIE05098"/>
        <property type="gene ID" value="D3H35_02915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="464"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE05098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="576" mass="65461" checksum="9B0744270DE8CE8A" modified="2018-12-05" version="1">MSARKLRFFFRWGRIRLPYKLLLVYTPLILLPALAGIYSLTASYTDSSKARTSEYATNLLSLMGQKIDDRLSSYEKLSKQIMTDDGLLSWISVKPKSIYENFEIQNAINEKLNVLWLGADQNAYIRAIKIVTPNAQYTYGKNAINDFGVGDANFNRQVADMKGSALWFIPEAYSDGYEKFEAFRLGRSIRDKKLNVLGTLTIIIRADAITDIFSQTKFHEDVAIKLLSSDNELILSNGVQIREDERQLLTYSQNQLHNEWRLSAQLPLNQLYEPIYRTARLAVFIVLICIAIGLVVTQLLAMDLVIPIRRLMLNMKHGIKGVRPGKLKRFGGAIEIVEMNDTFISVMYEIEQLVDEVSRQEAKKKDAEIRVLQNQISPHFLYNTLNSIRWMAMIQEQDNIKEMVDSLNRMLTYALRGQGGPVRLSKEIAVLHSYVTIQKVRYQHFQFTADIPDELENARVPKFLLQPLMENALIHGLAQADRPGEITVRARTEGAALLLTVEDNGIGIEPQRLAEIVGNFGQADNHFGLHSVHERIQLHYGRSYGLSITSIPGKGTEVTVTLPLQLHPNEEDEQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXF4</accession>
    <name>A0A398CXF4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">clpP</name>
        <name evidence="11" type="ORF">D3H35_07995</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03901">
        <property type="protein sequence ID" value="RIE03901"/>
        <property type="gene ID" value="D3H35_07995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00493">
        <property type="entry name" value="clpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE03901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="196" mass="21468" checksum="254A63A1DC16AEE3" modified="2018-12-05" version="1">MNLVPIVVEQTNRGERSYDIYSRLLKDRIIFLGSAIDDDVANLVIAQLLFLAAEDPEKDIHLYINSPGGSVTAGMGIFDTMQFIKPDVSTICVGMAASMGSLLLTAGAPGKRFALPNSEIMIHQPLGGVRGQASDIKIHADWIVKTKEKLNKIYVERTGQPYEKIERDTDRDNFMSADEAQAYGLVDKVISAPILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXP5</accession>
    <name>A0A398CXP5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03754">
        <property type="protein sequence ID" value="RIE03754"/>
        <property type="gene ID" value="D3H35_09355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046145">
        <property type="entry name" value="DUF6147"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19644">
        <property type="entry name" value="DUF6147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017270335" evidence="1">
        <location>
            <begin position="36"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="167" mass="17669" checksum="18E7483F5BF342DB" modified="2018-12-05" version="1">MNVHRGKKARKAVYRWLSLGLLSLLLIPFGTTAYAASGTSVRALTGAPPSELVAPMSIFNPSHLYLDSGGSSITASTGKVTVAASTTALIAVDSIGITFYVQKWNGSSWETVGSGTTTGGNNASSYTNSLARTVTSGYYYRSRTIHWVIENGVYEEGELFSSSVLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYA6</accession>
    <name>A0A398CYA6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA alkylation repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03984">
        <property type="protein sequence ID" value="RIE03984"/>
        <property type="gene ID" value="D3H35_08480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="228" mass="26469" checksum="EC0E2BEFB1D659A6" modified="2018-12-05" version="1">MEKTIKERLTESADEKYRLFSAALIPNINNVLGVRLPELRKMARTIAKGDWRAYLAEADDDYFEETMLQGMVIGCIHADIEETLRYVADFVPKIDNWSVCDSFCIGLKFTAGNRSRVWAFVLPYLSSESEYDARFGVVMLLDFFVEEEYIDRTFELLDGVKHEGYYVKMAVAWALSICFVKFPERTTALLKNNTLDNFTYNKALQKITESYRVSPDVKTRIRAMKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYF9</accession>
    <name>A0A398CYF9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiamine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_05175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04857">
        <property type="protein sequence ID" value="RIE04857"/>
        <property type="gene ID" value="D3H35_05175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="SSF89957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00106">
        <property type="entry name" value="TIGR00106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine_BP" evidence="2">
        <location>
            <begin position="4"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="105" mass="11611" checksum="67B83407459B5FBD" modified="2018-12-05" version="1">MAIVQVTVVPIGTGTTSLSGYVAALQQVLDQTKESIHYELTPMSTIIEGDLDVLLRVVKELHEKPFEQGAWRVSTSITIDDRRDKAGTMAQKLESVKKRRNEGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ47</accession>
    <name>A0A398CZ47_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation protein YqfD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yqfD</name>
        <name evidence="2" type="ORF">D3H35_06175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04204">
        <property type="protein sequence ID" value="RIE04204"/>
        <property type="gene ID" value="D3H35_06175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010690">
        <property type="entry name" value="YqfD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06898">
        <property type="entry name" value="YqfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029895">
        <property type="entry name" value="SpoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02876">
        <property type="entry name" value="spore_yqfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="414" mass="45708" checksum="7C617F3B310DC6F0" modified="2018-12-05" version="1">MRWTSLAGKGVGIMKGNWVAMLRGYAVVKLVGGNPEAFLNGVTKMRIVLWDIAFTSEKELRFGVSLPDFFRLRPIARDSGGKLRVLKRHGLPFKLARLSRRKTFASGLLGFVLLLFILSTFIWDVKVTGETAIPENKILQAAKAEGLHPYQWSFRLPDTSELAKRLSRHLPDASWVGVEKKGTKVVITVVDATKPDKKPLEGPRDLVAGADAVITRVIAENGRPQVERHDRVRKGQVLISGLLGDGGAHTKAVVSKGTVMGLVWHEYNIVSPLKRQVRTLTGESKERTYWIIGNRGLQVSGYGGEPFADSEIRATASKLRLGRWQLPFGVMNERELEAAVTETSLTEAEAKEAGLAQARKELLAKSGPGARITSENLLHEQTENGKVRMTILFEVEQSIAVERPLIQLPVDQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZZ8</accession>
    <name>A0A398CZZ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_00455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000005">
        <property type="protein sequence ID" value="RIE05437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05437">
        <property type="protein sequence ID" value="RIE05437"/>
        <property type="gene ID" value="D3H35_00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="105" mass="11808" checksum="B0C49B650ACBB156" modified="2018-12-05" version="1">MRLVSECRCIREPKAAPIALIFVIAWRTVGFAMVLILAGLKSIPKELEEAGEVDGASRWHTFWLIKLPLLKTPIMVTSIILMLSNFNNVDVPMVLTAADRAMRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D000</accession>
    <name>A0A398D000_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type 1 glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_07065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04494">
        <property type="protein sequence ID" value="RIE04494"/>
        <property type="gene ID" value="D3H35_07065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01382">
        <property type="entry name" value="PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="4"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="174" mass="19314" checksum="D05390C1C1378916" modified="2018-12-05" version="1">MTQKKVVCLIDDEFEDLELWYPVYRAREEGAEVVYAGPERGRKHIGKYGVPAVADISYEELDADSCDGLLVPGGWAPDKIRRDPKVLEFVRRMNEAGKPIGQICHAGWVLVSAKILEGRIVTSTPGIRDDMENAGATWIDEAVVVDGNIVSARRPPDLPPYAKAFCDLLYGRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D078</accession>
    <name>A0A398D078_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative NAD(P)H nitroreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_05670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nitroreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04574">
        <property type="protein sequence ID" value="RIE04574"/>
        <property type="gene ID" value="D3H35_05670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02135">
        <property type="entry name" value="YdjA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026021">
        <property type="entry name" value="YdjA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000232">
        <property type="entry name" value="YdjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 3" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="4">
        <location>
            <begin position="14"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="17"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="136"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="188" mass="21700" checksum="047EB8C6436FB6BD" modified="2018-12-05" version="1">MHQDQLEYPVAQLIRDRRTVRQFREDPVPQLLITKLLDIACWAPNHGFREPWRFIQYRGEARRTFAESVVATFSAEEKEKNGDRRLAYYMDIPVHLIVVAKEDPRAKQREEDFAAVCCWIQNFQLAAWERGLGVVWKTNPYLHAPAFRETVGVHAGERIAAVLHVGYPAAIPDARPRISGESLLTLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBA0</accession>
    <name>A0A398CBA0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-arabinose isomerase</fullName>
            <ecNumber evidence="6">5.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">araA</name>
        <name evidence="8" type="ORF">D3H35_28880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of L-arabinose to L-ribulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>beta-L-arabinopyranose = L-ribulose</text>
            <dbReference type="Rhea" id="RHEA:14821"/>
            <dbReference type="ChEBI" id="CHEBI:16880"/>
            <dbReference type="ChEBI" id="CHEBI:40886"/>
            <dbReference type="EC" id="5.3.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the arabinose isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.4" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00426">
        <property type="protein sequence ID" value="RIE00426"/>
        <property type="gene ID" value="D3H35_28880"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00145">
        <property type="reaction ID" value="UER00565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008733">
        <property type="term" value="F:L-arabinose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00519">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024664">
        <property type="entry name" value="Ara_Isoase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038583">
        <property type="entry name" value="AraA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004216">
        <property type="entry name" value="Fuc/Ara_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003762">
        <property type="entry name" value="Lara_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38464">
        <property type="entry name" value="PTHR38464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11762">
        <property type="entry name" value="Arabinose_Iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02610">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001478">
        <property type="entry name" value="L-ara_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50443">
        <property type="entry name" value="SSF50443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arabinose_Iso_C" evidence="7">
        <location>
            <begin position="360"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="474" mass="52996" checksum="D4F532729E3CD458" modified="2018-12-05" version="1">MSTTAAKEFWFVVGSQNLYGEDALAEVKANAQLMTDALNNSGLLPYPLVLQELAVSADKITSIMKEINYRDKVAGVITWMHTFSPAKMWIRGTKLLQKPLLHLATQFNESIPWATIDMDFMNLNQAAHGDREYGFINARLKKQNKIVVGYWGSLDVQRQIAEWMDVAVAYNESFHIKVARFGDNMRHVGVTEGDKVEAQIQFGWTVDYYGIGDLVQYVNAVTEQEIDELMAQYANLYESDYGANSKEAWEASVRVQASYEIAIKRFLDEKGYNAFTTNFEDLHGMKQLPGLAVQRLMAQGYGFAGEGDWKTAALDRLLKVMSRNQNTGFMEDYTYEMAVGQESILQSHMLEVDPTLASTQPKIMVSPLGIGGREAPARLVFDGKSGEGVVASIIDFGTHYKLLINEVSAFEPTVPAPKLPVARVLWNVKPNFQEGVKAWIENGGGHHTVVSFNLTTDQLVTYAKLVNLEYAVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBN1</accession>
    <name>A0A398CBN1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="3">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_27915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00566">
        <property type="protein sequence ID" value="RIE00566"/>
        <property type="gene ID" value="D3H35_27915"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011270">
        <property type="entry name" value="Pur_Nuc_Pase_Ino/Guo-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="PTHR11904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01700">
        <property type="entry name" value="PNPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="4">
        <location>
            <begin position="27"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="275" mass="29870" checksum="CBC62E66B80F8662" modified="2018-12-05" version="1">MGRLLDQIEEAKAVIEARLARADRPEIGLILGSGLGDLADRLEDALSVKYEDIPHFPVSTVEGHAGKLVIGKLNGKTVAAMQGRFHFYEGYTMQEVTFPVRVMKALGISHLIVTNACGGMNPAFSPGDLMIIKDHLNMTGSNPLIGPNEPSVGPRFPDMSRAYSPELVALVRETARELDIPVQEGVYAGITGPSYMTPAELTMLRQLGGDAIGMSTVPEVIVASHMSMKVIGISCVTDMAIGEHLEPLTHEQVMEVANRTKPRFTRLVQEIVRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBP1</accession>
    <name>A0A398CBP1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_27980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00576">
        <property type="protein sequence ID" value="RIE00576"/>
        <property type="gene ID" value="D3H35_27980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="300" mass="34015" checksum="D612963900D7E993" modified="2018-12-05" version="1">MEFRQLQYFVRVARLQHVTKAAEELHVAQSAVSRQIHRLEEELGVNLFMQKGRNVQLTPVGQLFLKRAEAILDDLDRSVTEIHEFLDPEVGEIRLGFPHSLGFHLVPQVVAAFRKLHPNVKFKFRQGMYPSLIKDVADAEVDLAFISPHPEKNDLVTGEIVLTEELFAILPENHPLSQQESIELNQLKEETFVLFSSGYSLRPIVWEACLEAGFTPKIGFESEETDTIRGLVAAGMGVSLLPEMALYRTSSMMPAVVKVSAPHVARTIGIIRRSSEKLPLVVHMFHSFLLEYFKSQYTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CC51</accession>
    <name>A0A398CC51_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00353">
        <property type="protein sequence ID" value="RIE00353"/>
        <property type="gene ID" value="D3H35_28435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="13"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="233" mass="25665" checksum="E8F21A2351642CB4" modified="2018-12-05" version="1">MVQIQGGTAVVAGATGLVGQELVRMLLEHPSYSRVIALVRRELGFSHPKLEERRISFDRLEEEIDEQLLRDADVFCALGTTIKQAGSKEDFRRVDYAYPLALGRAARRYGAACFVIVSAMSSSERSMMFYSRVKGEVERDLAALGLQRLVVLRPSLLLGDRTESRPGERLAIVLSRPLGALMIGPLVKYRAIDSRDVACAMIAAARNEGPAHEVLESNEISSLAAAVRRKRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCJ6</accession>
    <name>A0A398CCJ6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00916">
        <property type="protein sequence ID" value="RIE00916"/>
        <property type="gene ID" value="D3H35_25435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="62" mass="7367" checksum="9F952A49CDADDF69" modified="2018-12-05" version="1">MACEERAFIVKRHPFILRMPFLLAAIVLPRSWFEQNSLVFLPLSAIPEDFRFPIYKKLLMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCP0</accession>
    <name>A0A398CCP0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_28275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000055">
        <property type="protein sequence ID" value="RIE00480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00480">
        <property type="protein sequence ID" value="RIE00480"/>
        <property type="gene ID" value="D3H35_28275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="307"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="855" mass="95348" checksum="91A372146E61958E" modified="2018-12-05" version="1">MLLNCLVILCTLCQKVAFDGQRLLQYYKTHRIDISDGTPAHLKMISQAAIQVSVLGVKQFIVGGELLLGSVVDDFLKKCSDHVPLITNVYGPTECCVDTTAYFAFERNGWQSDAIPIGTPLLNQQVYILDRQKKLVPIGVAGEICIGGNGVGRGYFGNPVLTSKQFVANPFAPGERMYRTGDLARWLPDGNIEYLGRIDEQVKIRGHRIELGEVESALRSHESVKEATVIARKDEEGSAYLCAYFVANGNLGAAELRKHLSEMLPQYMIPSFFVRVEQMPLTPNGKLDRKALPSPEGTLERGTVYEAPRNALEETLANIWQGVLGVSAIGIADNFFELGGDSIKAIQISARLHAHHLKMEIKDLFQHPTIGELSSCLRPVGRTIDQGLVEGEVELTPIQRWFFEQNFTDRQHCNQAVMLHRKDGFDERIIREVLAKLAEHHDGLRMVYHPGSVGYTQRNRGMEREVFHLEVRDVTGDQQAEEEVIQACATEIQASMDLGKGPLLKAGLFKTAEGDHLLLAVHHLVVDGVSWRIVLEDLNTGYRQAMNGEAIRFPAKTDSYQAWAKALQGYANSGQVLEEAEYWQAVERAEVKPLRKDSEVGAGLMKDGRHVSLTLTEEQTEKLLKQVNKAYNTEINDILLTALGLAIGEWNDSKQAAIELEGHGREEIGHEVDISRTVGWFTTQYPVILEMEQSRELSYQIKTVKEHLRRIPNKGIGYGLLKYGKAAAEGRTWKLKPEVSFNYLGQFDQDVETGLFAGSRYGAGSSVSPNGERTSTLSINGMVLGGQLQLTIDYNGKAYEADTIEKLAAVYKRHLEAIIEHCASTDNREVTPSDLTYKRLTIKQLENLEDKINFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCR5</accession>
    <name>A0A398CCR5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathionylspermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00205">
        <property type="protein sequence ID" value="RIE00205"/>
        <property type="gene ID" value="D3H35_29655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005494">
        <property type="entry name" value="GSPS_pre-ATP-grasp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03738">
        <property type="entry name" value="GSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSP_synth" evidence="1">
        <location>
            <begin position="24"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="443" mass="50575" checksum="B06B3C04DEE0311F" modified="2018-12-05" version="1">MDRILSIGKRHDEVFQGEIADRIPYHRMNGKEYCVPAFTMYKSSEVLELQNASERVDKVYWKVLRFAQKYLPDSFLVNQLGILPALIPAARMEIPYHGVSRQDWIINDSGMKCIENNTDTPTGIPETSYLANELTSRYSSLPSTSPNMKSSIQESFAKLIEFYLLKGIKGTIAFSSYEWHLEDRINTEYVRECIDDLGYDSIYVPLSELEIVPNDGLYANGERIAILYRLYPLEYLVHDTDRDGCEKIGIALLNLVVQGKLALINPVQSVITQSKGFMALIWSLFERRDETEEFCGFSLFNDEDIQTIETYLLPSYYEATVFIQNETPYVAKSFWGREGKGTSLFDGNGALLHAESVNDIDDEESEIRHYYNNQPKIYQKRFPLQEVTIMTEDGPYSGYLLTGTYVIGGHCSGILPRIGDEITGDMAFYSPAVIIAEEEDYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDP6</accession>
    <name>A0A398CDP6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00555">
        <property type="protein sequence ID" value="RIE00555"/>
        <property type="gene ID" value="D3H35_27845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="169" mass="18292" checksum="81821740BBE1178D" modified="2018-12-05" version="1">MSIKLQSTKRCSCHHPPKKRRRKRRHNTYQGNTVTSPAETVYPPGAGGTGDWVDGFGGLGLGDLGGSWPAGEGENTYAANPVDHRTAGRHHTGGHHRTGGHHRTGGHHRTGGHHRTEGHHRTAGHHTAGHRTAGYETEHRTQGYVAGRLAVPRKRSKPASKKCGCKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDX3</accession>
    <name>A0A398CDX3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_26995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00830">
        <property type="protein sequence ID" value="RIE00830"/>
        <property type="gene ID" value="D3H35_26995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="59" mass="7229" checksum="6E8D322B77E223E7" modified="2018-12-05" version="1">MYSICCRQWYAKYNLNLQGNEAQNEIQLTMEYSIKLFKRETIIRLVEDYQKYIVTNNWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEH1</accession>
    <name>A0A398CEH1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Branched-chain-amino-acid aminotransferase</fullName>
            <shortName evidence="15">BCAT</shortName>
            <ecNumber evidence="15">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">ilvE</name>
        <name evidence="16" type="ORF">D3H35_26905</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 15">Acts on leucine, isoleucine and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 15">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 15">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 13">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="15"/>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00845">
        <property type="protein sequence ID" value="RIE00845"/>
        <property type="gene ID" value="D3H35_26905"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050048">
        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005785">
        <property type="entry name" value="B_amino_transI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01122">
        <property type="entry name" value="ilvE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="12 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15 16" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00003109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RIE00845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="287" mass="31702" checksum="3B690C6FA549A2AF" modified="2018-12-05" version="1">MNGELVKRDEAVVSVYDRGFLFGDGVFEGIRAYNGNVFKLKEHLVRLFDSAKAIMLNIPLSHEEIEQAVVKTLKKNQLHTAYIRIIVSRGVGQGYNLDPFVCNRPQLFVMTEGFEAFPRHLYETGIDIVTVATRRNRSDVLSPQVKSLNYLNNILVKIEAIQAGAKDGLIMNTDGYVAEGTTNNIFIVKNGKVVTPAIYQGALEGITRSSIIEILNKFQVAVNESPLTRHDIHTADEVFLTGTASEVIPVVKVDGRVVADGKPGEKTRLLIDAFQQLAVTDGVKFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF10</accession>
    <name>A0A398CF10_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Maltose ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01160">
        <property type="protein sequence ID" value="RIE01160"/>
        <property type="gene ID" value="D3H35_22410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="334" mass="36922" checksum="6D44852901EEDED0" modified="2018-12-05" version="1">MKTDGQAGTAADILTQPHNDLGNAVKSGFVLPNDYYEEQTREEFIQPAVDAVTNNGVLYGYPRNMETYALFVNKDLVKDAPLNTWDDIIAFAKSFNDIKNNKYGYMSRLDTLYFLYPFFSGYGGYVFGNNGTNPDDIGLNNEGSVEGMKFFRTLKEILPMAPADASDDIKTSLFQDGKLAINLDGVWNIGNFSKLGFNATMIPLPTLPNGKTPISFAGVKAYYVSAYSKYPNAAKLFARYVTSKDALLKNFEMSGFIPARKGMAEESAIKNNEMVVSALKQLENSMPMPSIIEMNSVWVPIQQAMELIWNGGDVKASLDKAVDDIRIGISTQND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFB0</accession>
    <name>A0A398CFB0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_22005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01095">
        <property type="protein sequence ID" value="RIE01095"/>
        <property type="gene ID" value="D3H35_22005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013571">
        <property type="entry name" value="Tscrpt_reg_QacR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08360">
        <property type="entry name" value="TetR_C_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="195" mass="21903" checksum="42F423F090581803" modified="2018-12-05" version="1">MTKRAYDAEHTKKKLLEGAMVLFAKKGYAATSIDDICEASGCSKGSMYYHFRSKEQLFLELAEQAFSDSWRRWNELSAPLSTATDKLYAYADYFVDNHNRPLNKAGEEFIAKIGAASEAGQRFFGIVMGVIADFESLVSEGIASGEFKNEDPKELAFIILSYFSGLSDSYLFMDRDGMKRLFRKAAGFLLEGIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFR8</accession>
    <name>A0A398CFR8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01275">
        <property type="protein sequence ID" value="RIE01275"/>
        <property type="gene ID" value="D3H35_23085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="171" mass="19966" checksum="E5DB168C37EBFEE4" modified="2018-12-05" version="1">MDFLNNIKELKDFSLKKLLIISSTVLLFLYYFKESYSKEYNNFLLTIDHWANKLNYSEWSSVIIILQRFIGSLSLISLVLYVITAIIYSTIWSRMYNSRFLNSKRKDFMDGVGKLYLSSSISYLNIIGYSEILNGKYIRSDVFKSLGLLSIGIILVYFLAFMISNNDDGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFV9</accession>
    <name>A0A398CFV9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_24990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01603">
        <property type="protein sequence ID" value="RIE01603"/>
        <property type="gene ID" value="D3H35_24990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="16"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="214" mass="23777" checksum="836425D866ADC29D" modified="2018-12-05" version="1">MWDLFVSSFPSLMDGMLMTLRITVVALLAASVIGFIIGLMNISHFKALRAAAIAYIDLIRGTPLIVQAFFIYFGLPSVLDFRITALTAGTIALSLNAGAYMAEIFRAGIQSVDKGQMEAARSLGLPYRRAMLKVIMPQAIQRMIPAILNQFVISLKDTSILSAIGIRELTQSGEIIIAGNYKSFEIWGMVGLMYFVVITMLSYVSRRIERYYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGA6</accession>
    <name>A0A398CGA6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_13245</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01763">
        <property type="protein sequence ID" value="RIE01763"/>
        <property type="gene ID" value="D3H35_13245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="205"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE01763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="419" mass="47559" checksum="75C6F24AAA9A8431" modified="2018-12-05" version="1">MFNKLRNRFLVVNLVIISFMMLLAFASIYTITYQNVRNDIEMELQRVSEFYHKPDGNVGEPRSGGNHRMKESIVNTGPPPERSVSFSLQTDEQWNITATNSRFEMDSDFYDLAKNKVASDRSNTGQFSLDGNKWAYTLQKNEAGYFIVYLDVTAQQKIITNLVYTFLAVGLVMLIVIYFTSRFFANRSIAPVKEAFDKQKRFIADASHELKTPLAVINTNADVLLSNSDDTISNQSKWLHHIKSETERMKTLTNDLLYLTEMDDARASMIFTSFNVSEAVEGVILTMEAVMFENNISLSYELEPDLTVRGNGEQIKQVVMILLDNAIKYTNPKGAITLSLKKRHNDIVLKVTNSGAGIPPEHLERIFDRFYRADPSRSRKYGGYGLGLAIAKSIVEQHKGKIYAKSVPNETTSFYVQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGF2</accession>
    <name>A0A398CGF2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphoglycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_24800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01570">
        <property type="protein sequence ID" value="RIE01570"/>
        <property type="gene ID" value="D3H35_24800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="4">
        <location>
            <begin position="13"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="5">
        <location>
            <begin position="113"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="319" mass="35016" checksum="BCEA353A0CAEB784" modified="2018-12-05" version="1">MKKVLAGIPNFLEQCPEASELLRENGFEIIDIQSEPIIPFDKLEDVLPELDAVMIGGNGSWDKHILEKASKLKVISKTGSGTDNIDLATAKQRGIRVTNTKGSNTNAVAELTIGLMITMLRHVPIFNQQMFEGEWNRTMMGSELKGKTIGLIGFGQISQKIASLLSVFETNILAYDVFPNHLRAEELGVTFVELDHLLGNSDIISLHTPYMKETHHLIGDKQFALLKEGASVINAARGSLVDEKALYRALCSQKVASAALDVFEEEPVNPQNPLLKLDNVICMPHIGGTTCESLQYESLTIAKAIIDVLNGREPQNIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGM2</accession>
    <name>A0A398CGM2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_25145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01630">
        <property type="protein sequence ID" value="RIE01630"/>
        <property type="gene ID" value="D3H35_25145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="70"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="294" mass="33093" checksum="2A373A9D07316AD1" modified="2018-12-05" version="1">MKLNWARRQQLIGYMFIAPNMIGVSCFIIIPALFSIVLAFTNWEFPQLTADFVGLSNFSRLVHDDVFYHSLKNTLIFLGSVPISVGLGFLTALVLNKSVYLKNVLRTMFFLPYITTGIAIAFVWMLIFQPVNGPVNSLLMSIGIDHPPGWLSSTSSAIFVFDIIWIWFLLGYNVIIYLAALQEVSGELLEASKIDGARMLHTIRYIIWPLVSPTTLFLLMTGFIVSIKQMGIFQAITDGGPGDSTTVLSLYIYKTAFRYYDMGYASAISVCLLLIIIIITAIQWIAQKKWVHYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGP8</accession>
    <name>A0A398CGP8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_16875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02386">
        <property type="protein sequence ID" value="RIE02386"/>
        <property type="gene ID" value="D3H35_16875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="312"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="597" mass="68703" checksum="5DBD5528BD7729AE" modified="2018-12-05" version="1">MRMSFWQSVRFKIVFGFALIIAPLVAFLIYNNVYATGVVRNQISNNYNKLLAVSVNENDKILKEYRYYLLRLARDPDIPIIQSYPSDSDEYILAKLRLLNRYALDSLLDSTSIYGILDTLFLYPRKEQSIIFATQYNTNSEEKETTLNEWSRTHLTGPIEHDYRWESITVEGGYHYLLKAVDLDLNVYAGALVPSDSMMRVLSNFDVGPSGAALLLDSSGVSLTSRVFKPMEDPDFFDAVTRMNDSYKIVRSQGENYLVMAKHSQYADLNYVLITPESYILKSLPFFQKVLYIWIPLLVALLLSFYLLFLQRVVFKPLVELIRGMRKLGQGRLDIRLPTNQSSEFAFMSGSFNQMAEQIEKLKIDVYEEQLRVQKAEYKHLQVQINPHFYMNSLNIIYNLAALKDFKSVQKLSLHLADYFRFLMQSNRPVVSLEDEIRHIGHYLEIQKVRYVTKLDFEIDVKPEHLKAEISPLTIQPFVENSVIHAFNKRVQDGSLFRIAIRSEDGEDELGSYVVITVSDNGPGFPEDMLRDLGSDAYLAGTGEQHLGIWNILRRFRMLYGDAGRIVFRNADEGGAVVEIWLPAAFKLPVGRDEPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH02</accession>
    <name>A0A398CH02_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_28465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00359">
        <property type="protein sequence ID" value="RIE00359"/>
        <property type="gene ID" value="D3H35_28465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="137"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="359" mass="40151" checksum="AF24200DC1FFBBCC" modified="2018-12-05" version="1">MTKQLKVGIIGQGRSGRDIHGSLLNKLGEKYRIAAVADSIPERQELAKSEYGCSAYGTWEEMTEREELDLVVNASPSDRHFGISLELLNRGFNVLCEKPLAKTVEEVDRLIEASERTGKLLAVFQNSRYAPAFVQLRKVIDSGVLGRIVQIDLCINGFARRWDWQTLQENNGGNLLNTGPHPVDQALQLFGTDISPEVVCVMDRANTFGDAEDYVKLLLKGEGRPTIDIEISSCSVYSAAPFVVQGTNGGLCGDGERLEWKYFKPEEAPEQQLTRGPLLNANGLPAYCSETLVWHEESWELESTEGRTVFEGTTEQVYLMLYRTLVEGAPLEITPLQVRRQLEVMEACRKQNPHIYKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH53</accession>
    <name>A0A398CH53_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00419">
        <property type="protein sequence ID" value="RIE00419"/>
        <property type="gene ID" value="D3H35_28830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="80" mass="9161" checksum="E94C44309F008E6B" modified="2018-12-05" version="1">MFEKSVLLFILYAALFIYDGPKLKMRSLRLKLGYGLLMTASVYLSVDYLLSLHAPNLDDFFDFIFKDAAKHIVEAIKIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHL4</accession>
    <name>A0A398CHL4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000051">
        <property type="protein sequence ID" value="RIE00599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00599">
        <property type="protein sequence ID" value="RIE00599"/>
        <property type="gene ID" value="D3H35_27455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="87" mass="10069" checksum="DB4C09B7958AE653" modified="2018-12-05" version="1">MPLFDTEKVEAVFIDVAYSDPDNRYEREEQLKIKKEMTDSVPLTLAIVNPALKAFRYRLTFIGTDRSMRRGAFVETAETLIPVREDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHW7</accession>
    <name>A0A398CHW7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000055">
        <property type="protein sequence ID" value="RIE00478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00478">
        <property type="protein sequence ID" value="RIE00478"/>
        <property type="gene ID" value="D3H35_28265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="17"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="160" mass="18153" checksum="1866AE4D6A2ED172" modified="2018-12-05" version="1">MVNYVSWANKVYMQEDRLDSALFSSISFDLTVTSLYLPLITGNKVVVYHGENQASVIRRIIEEDKVGLLKLTPSHLKLLETDRRLSSSTSMKRLIVGGEDFSHALAQSIYEKYEGKVEIYNEYGPTETVVGCTVYLFDAGSKGYTSVRLGFLHPTYKYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHZ6</accession>
    <name>A0A398CHZ6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02060">
        <property type="protein sequence ID" value="RIE02060"/>
        <property type="gene ID" value="D3H35_14955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045527">
        <property type="entry name" value="DUF6470"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20074">
        <property type="entry name" value="DUF6470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="188" mass="20936" checksum="1C249509264BC5F2" modified="2018-12-05" version="1">MNDLRLSIRQTNAQIGINTQWASQDRQAPLGEQSIRQPMAKMDIRQPMGELTIDSTAAYIGLGQGPHLQFMNSIYSQSESVLLQAIAKIVADGNRMAQITNPNNAFAEIASRAIPTSSPYQYLGDASCLNVKINYKANAPIINIEAQSPQIEYTPRSPEVQYNPGSVEIYLKQRNSIDIQVTQYDLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI94</accession>
    <name>A0A398CI94_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_15095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyltransferase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02085">
        <property type="protein sequence ID" value="RIE02085"/>
        <property type="gene ID" value="D3H35_15095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="14"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="339" mass="38339" checksum="FC326A8E354D6899" modified="2018-12-05" version="1">MSSQKILTSQRILGYDLSRTFAVIFVFVAHIILAQWDNKYSTIFFTSFSPGVTMSLLGFVSACLLANSESVDNKFSHFLFRRITRIYLPMILCLTFAAILAKSLGTSIQSDHLIYHYLGAALFFDWLKVPNNASVGWGLWFVTAILIMYVLLPVLKLAFKHRNGRLHFILFYILCVTINIVSVPPESSFWNVAVSFGFGVYLASNGLLSKVLNLKLVWAVPLAILLLFICSLCSAGIIHFDIRKLLFPLYPIAFMPIFFSLASRISGLLEKSISKFSEISFEFYMLQFYFINGGFTKIFGGQFHLVWQIVIGFCAALLVSILLAEIGKRLRRAADNYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIH7</accession>
    <name>A0A398CIH7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RCC1 repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02543">
        <property type="protein sequence ID" value="RIE02543"/>
        <property type="gene ID" value="D3H35_17795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="SSF50985"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017416144" evidence="1">
        <location>
            <begin position="34"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="994" mass="102021" checksum="38AA63B29D7AF497" modified="2018-12-05" version="1">MFRWNKKLSCLLAVSLFLQVLGLWGFEPQKAEAAIDPSILSTLVAAGTSHTLFVMPDGTVKSSGSDGGYGALGQGSGTTQVITPATVPGLSNVKQVAAYGYNSYALLKDGTVKSWGYNSNGELGVGNASTTYTPTTISGLTNVKQIAAGNGFAIALLQDGTLRGWGINSTSVLFTLPTISIPMTLSGIDNVKRIAVGQNFVIALLNDGTLKTWGTNSNGQLGIGTTTAQSAPAAVSGLSNVIQVAAGYTYGMALLEDGTVRTWGNNTNGQLGINNTTQSNTPVQVSGINNARYVAAGGYSSYAVLKDDSLMSWGNNTNGQLGLNDATHRFIPTLVSLNLSVAGLFASHNNSAVLVGLDGKLFVSGYNNSGQLGTGVSSNSYSVFNANGINIQADMLDMQLSITTDVAFFSGPNSSSAFLLQNGTVKAWGNNASGQLGLGNKTSQSIPAVISSLSGVKQIAGSSQHSVALMEDGTVKTWGNNSYGQLGLGNTTEQTTPKAVPNLSGVKQVAAGENFTLALMADGSVKAWGSNSLGQLGLLGTSQSSSPTTIVSLIGYKVKQLAVGSNYSLALVEDGSVRTWGSNSYGQLGLGNTSNQTVPVLIPGLNGVKQLTAGFYHSLALMEDGTVKAWGLNASGQLGQGNISNQTTPAAIPSLSGIKQLAVGSYYSLALMMDGTVKAWGNNNSGQLGLGHTIDQTTPTSIPSLSGVVQLIAGRQFAMALLEDGTAAVWGDNSNGQLGQSSPNYQIMPALITALSGVKQLAAGEKHSLALMEDSTVKAWGDNVYGQLGLGDISNQMTPVSIPSLSGVKQLVSGSNHSLALMEDGTVKAWGYNGMGQLGLGHTNSQSAATTIASLSGVKQVAAGSYFSLALMEDGTVKAWGTNSAGQLGQGNTTSLSKPTAVSGLSGVKQVAAGSTFSLALLENGTVKAWGYNYFGQLGLGSTINQTVPSDISPAILSGVKQLAAGAYYTMALMEDGSVKAWGGMMRGSWGWAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIS3</accession>
    <name>A0A398CIS3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02633">
        <property type="protein sequence ID" value="RIE02633"/>
        <property type="gene ID" value="D3H35_18300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="23"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="270" mass="29401" checksum="B11E657CF7709FD7" modified="2018-12-05" version="1">MRNLRRSTSTTMACQDEGTGTPIVLLHGYCGSHRYFEEILPILSAKYRVIVPDLRGHGSSSATEGVYKMEQLADDLDVLLDAMQLSKVFLFGHSLGGYVTLAFAQRHRERLLGYGLLHSTSLPDTGPGKTGRLKAVDQIRTGGISPFVDELIPKLFAKDHRETMKGKINFAKEIGYGTAPQGAIGCALGMRERSDRTNVLEMPDLPVLLLAGEKDDIITPDRRFPILKPKPHLTQVTLKGVGHMGMLEAPQEFADALISFIAANEGSGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJA7</accession>
    <name>A0A398CJA7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03396">
        <property type="protein sequence ID" value="RIE03396"/>
        <property type="gene ID" value="D3H35_12025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="254" mass="27576" checksum="CF754AC9EADC4086" modified="2018-12-05" version="1">MVNIDLSGKTALVTGGTGQLGRVMVRTLAECGANVVIHYNSNEEKALELRDEIRSLGRHSAIVRADITKKEAIFAMKSEAEGELGPVDIVIANAVVQYAWTSVLEQAPEDYVSQFESCVMQSVYLAKAFAPGMIERSWGRIIGINTECAMQNDPTQSAYVAGKRGMDGVYRVLAKEIGKHGITVNQVAPGWTISERDRENHTERSEGYESAVPLRRRGTDQEIANAVVFLASDLASFITGAFIPVNGGNVMPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJH8</accession>
    <name>A0A398CJH8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_19695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02853">
        <property type="protein sequence ID" value="RIE02853"/>
        <property type="gene ID" value="D3H35_19695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="270" mass="30126" checksum="A150D7146DD4CE9D" modified="2018-12-05" version="1">MALADASSTTITIERLNKSYAELKPGKAGSVHYIIKDIDLVIKGGEFFVLLGPSGCGKSTLLNIIAGFVSKSGGHLRVGSVEIEKPGRERAVVFQQADSSLFPWLTVRQNVEFGLKMQKMPKERRKEISDRFIKLVGLFGHENKLPRELSGGMKQRVQLARVLANDPDILLMDEPFGALDAMTRRLMQKELGQIWRETGKTVIFVTHDIQEALLLGQRIAVMSSGPDAHISDIYDVPLDYPRDVSSREFFALNRRIQSHFDAELEGASYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJN0</accession>
    <name>A0A398CJN0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Crp/Fnr family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_12250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03526">
        <property type="protein sequence ID" value="RIE03526"/>
        <property type="gene ID" value="D3H35_12250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018335">
        <property type="entry name" value="Tscrpt_reg_HTH_Crp-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00034">
        <property type="entry name" value="HTHCRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00042">
        <property type="entry name" value="HTH_CRP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="18"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="4">
        <location>
            <begin position="152"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="246" mass="27782" checksum="14CD0159314DDD92" modified="2018-12-05" version="1">MEAHRYELAAKTENPLGIAAFFSEEQFGMLEEIMYPKRASAGNCVFREGDVSDKLYYIRSGKIKLKKTTEDGKEFIISILQAGDLLCEPEDGMTQQHSYCAEVMEHTELGVIQRKDLDIILYRNGDFAMRFMKWMALLHRITESKFRDLLLFGKPGALASTLIRLSNSYGIACPEGIRISLKLTNAELADFIGTTRESVNRMLSALKDDGAIELRKGYIVILSLEKLRGICHCPSCPQCPKEICRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJW2</accession>
    <name>A0A398CJW2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclic-di-AMP phosphodiesterase</fullName>
            <ecNumber evidence="1">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_24245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3',3'-c-di-AMP + H2O = 5'-O-phosphonoadenylyl-(3'-&gt;5')-adenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="ChEBI" id="CHEBI:138171"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="2">For phosphodiesterase activity, probably binds 2 Mn(2+) per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GdpP/PdeA phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01469">
        <property type="protein sequence ID" value="RIE01469"/>
        <property type="gene ID" value="D3H35_24245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106409">
        <property type="term" value="F:cyclic-di-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014528">
        <property type="entry name" value="GdpP/PdeA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026583">
        <property type="entry name" value="YybT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="179"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR026583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR026583-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="660" mass="74154" checksum="D31D822837325B22" modified="2018-12-05" version="1">MPKFLVQRWHGMHIVWALLLIFMLTVALAWYHWVLGLIGLILGGAVAAFGILAERAFRKDLNDYVLTLSHRIKSVGSDVIGHLPFGIVIYNEDKDIQWHNAYISTVVGRPSVVGETLTHIFPALQQASKEKEKDKDKETVVETTIGGRVFELMFRPAERMVYVSDITERWTLKKRYEEEKLALGIVIMDNLEEIAQGMDEQQRAIMLSRVTGEINEWALRYGLYLRRLSSDRYMIITNLGTLKHLEQTRFDLLDEVRELTQDQKLPMTLSIGLASGVDNVVELGHLAQSSLDIALGRGGDQAVVKVGQRQNFYGGKSNAVEKRTRVRARVISHALRDLIKESDHVIVMGHKMPDMDAIGAAIGVVKAAQICGKEAYIVLEGINPAIQKMMEMLKEDEKLIRRFISPEQALALMHKRSLAIVVDTHKATMVAEPRLLQATDRIVIVDHHRRSEEFIDDAVLVYMEPYASSTCELVTELLQYIHERVALDVREATALLAGITVDTKSFALRTGSRTFEAASFLRRNGADSMLIQRMLKEDLEEYVKKAEIIRHANVYREHIAIAAYDSGKQVPQLLIAQSADTLLNMTGIKASFVVAQRPDGLIGISARSLGQINVQIVMERMGGGGHFTNAASQLQGTVQEVADKLKQTLIELEDKERLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJZ0</accession>
    <name>A0A398CJZ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00197">
        <property type="protein sequence ID" value="RIE00197"/>
        <property type="gene ID" value="D3H35_29610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="171" mass="19586" checksum="0D76093B8884CD4F" modified="2018-12-05" version="1">MTTHCQRCVSEDDFAKASLFMLAHKRDLHLSYTTLEMVTLIYSYITQGHLICTIDADHRVVAVGAYYYGTPDQEFQDKDVALLDIAIIDKGFRGSRLFIQGLQYMVNAIGEEHPEVRELRLAALAGNDYLCRLYAKFTSSRFDREGTHGKEVVFCEEMNTLRGTLKKYSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJZ2</accession>
    <name>A0A398CJZ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02665">
        <property type="protein sequence ID" value="RIE02665"/>
        <property type="gene ID" value="D3H35_18475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="177" mass="19222" checksum="231487C349264F1A" modified="2018-12-05" version="1">MQEPVAGRKSKWAAGIFSFFVPGTGHMYLGLMVKGIIMMLLLVFDICAIYYMATEGKNDLSVVLLSLLLPIIYFYSLFDSLQSTDFVNERIARRPGFPSQEGWNGMPPAHEGAGQSVPAASVVLIVVVLAAIVVTVGSDWSRNVIHSSGTLITAVVLIGVGLVLWLVHKWADNGKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK17</accession>
    <name>A0A398CK17_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Guanylate kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00227">
        <property type="protein sequence ID" value="RIE00227"/>
        <property type="gene ID" value="D3H35_29780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="188" mass="20961" checksum="A04673CC639ADDBE" modified="2018-12-05" version="1">MTRMGKIFVLYGPSASGKTEIQKQITSGRLPRIITATTRAPRDNEIDGEHYIFMSKSEFRSQIENGRFIEWTEYGNELYGTLKDSAENIVSGNGSANIILDFAGVRALKRLYADTFAIFIGANIESIERRLLLRAGTDEELNGRLTRARELELSPEYLALADAVVWNDDGADFEETLAKVQGIISSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK69</accession>
    <name>A0A398CK69_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small acid-soluble spore protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_19060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha/beta-type SASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02745">
        <property type="protein sequence ID" value="RIE02745"/>
        <property type="gene ID" value="D3H35_19060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001448">
        <property type="entry name" value="SASP_alpha/beta-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018126">
        <property type="entry name" value="SASP_alpha/beta-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038300">
        <property type="entry name" value="SASP_sf_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00269">
        <property type="entry name" value="SASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00304">
        <property type="entry name" value="SASP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="73" mass="7990" checksum="5FB3DBFB590C0B5D" modified="2018-12-05" version="1">MASSRSSNSLVVPGSRQALERLKFEVAQELGIQLPADGYYGNMLTRDMGSIGGYITRRLVQMAEQQLAGSPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKK0</accession>
    <name>A0A398CKK0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000038">
        <property type="protein sequence ID" value="RIE03243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03243">
        <property type="protein sequence ID" value="RIE03243"/>
        <property type="gene ID" value="D3H35_12775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="316" mass="34855" checksum="E921899DF40AA364" modified="2018-12-05" version="1">MLHRWLEIRSDSPLPLHAQLTEQLKWLVGSGRLSPNDLLSPVASLAHELGVNRNTVQAVYMQLREEGIVETRQGHGSWIADTEATRKLIIERQASAPVARGLLDSAEEAGFDVERFVYLSMAALQLQALKDRRPRVLFVDSRLGEHAFFLEEIRRVTGGQPAWLALEELRRDLEGSSSLAGRYDIIVTTSAGMDELRCLLPSVADRAIRVEAALDLKMIAEMARLGESREIGVVCAEPFMAGWLAERLAALGSGYTIALAGDRESLRSLLGRAANVYAAPSVYDDVKSLAPEKTSLLSLVLETSSEYLLADLKKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKQ1</accession>
    <name>A0A398CKQ1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="7">GSA</shortName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="7">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">hemL</name>
        <name evidence="9" type="ORF">D3H35_07915</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03886">
        <property type="protein sequence ID" value="RIE03886"/>
        <property type="gene ID" value="D3H35_07915"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="435" mass="46493" checksum="DDC520184038F7DC" modified="2018-12-05" version="1">MSENRRNRSDSRSKAAFEKAKRFIPGGVNSPVRAFKSVGLTPLVIESGSGSRITDIDGQTYIDYVLSWGPLIAGHAHPTVVEAIKRTAEKGTSFGAPTELETEMAELVSERVPSIDIVRMVNSGTEATMSALRLARGYTKRSKILKFEGSYHGHADSLLIKAGSGVATLGLPDSPGVPESVAAHTITVPYNDLESAKAAFEKFGGDIAAVIVEPIAGNMGVVPPLPGFLTGLRELTTNYGSLLIFDEVMTGFRVHLNCAQGLFGVTPDLTCLGKVIGGGLPVGAYGGRRDIMEQMAPVGPIYQAGTLSGNPLAMAAGLATLKLMNAESYQLLERLSARLQLGLENSARETGIPLTINRIGSMICPFFTDEHVINFETAKRANTERFRSLFAKLLDRGVNIAPSPFEGLFVSTAHTEADIDSTIEAYKDAFSELND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL04</accession>
    <name>A0A398CL04_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000060">
        <property type="protein sequence ID" value="RIE00301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00301">
        <property type="protein sequence ID" value="RIE00301"/>
        <property type="gene ID" value="D3H35_29345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="86" mass="9588" checksum="A710CD6AB48F1A05" modified="2018-12-05" version="1">MKPALLENWKSKYPNVELINMYGITETTVHVTYKQMKQTEIEGHISNVGQPLPTLHTYILGSDHKLRPVGVPGELYVAGNGLARVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLK9</accession>
    <name>A0A398CLK9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_13105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01738">
        <property type="protein sequence ID" value="RIE01738"/>
        <property type="gene ID" value="D3H35_13105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="3"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="321" mass="35045" checksum="2EE914CB3B47DF5E" modified="2018-12-05" version="1">MYDIIALGELLIDFTPLGMTAAGRPYFEQNPGGAPANVAACLARLGKKASFIGKVGDDSFGKYLDGVLKGYGVDTTGLIFDPNGNTTLAFIHLSEQGERSFSFYRRPGADTLLTIQDIDLSRIERSRVFHFGSLSMTDNPSRMATLMAAEHARKKGIPLSFDPNLRLPLWSSPVKARDMMIVGLQLASIVKVSEEELEFITGIQDYEEGTRFIYETYGVPLIFVTLGERGCFYRIRTETGISRGYSVQSIDTTGAGDAFLGAVLLKWLDKGVEINQLSANDVAHFCDFANAVGAIVTTKMGGMSSLPDLEEIESFISRTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLV9</accession>
    <name>A0A398CLV9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CheX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_27070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00631">
        <property type="protein sequence ID" value="RIE00631"/>
        <property type="gene ID" value="D3H35_27070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028051">
        <property type="entry name" value="CheX-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13690">
        <property type="entry name" value="CheX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheX" evidence="2">
        <location>
            <begin position="83"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="202" mass="22272" checksum="36D1E12B7223BB09" modified="2018-12-05" version="1">MSNWAERLRFARKSEPAHRSFLRCRKVHGEGTIGLEPNYEAGDPDLFPGLLSSAEQYLGTLGIGELKRISTEQGSDGLPLEDVTAFIQVSGSLQGGFLFSADHSLSRELARKFMIEEITDLEAAQYAVETVAEVANVITAASLNSREETGIYLGNPLMILSRDMGVRAGRYETQAYETPSGRCRFFYIPKMEKAELASIVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLW7</accession>
    <name>A0A398CLW7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_10100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03643">
        <property type="protein sequence ID" value="RIE03643"/>
        <property type="gene ID" value="D3H35_10100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="192" mass="21730" checksum="43720736B3684EFB" modified="2018-12-05" version="1">MKRDEKKAQTHQRIMNSAIELFDELGYESTTVQHIADRAEVAKGTFFNYFASKEDLIMELQGMMILQQMENVSGKPGPVIPRMQSVLFEHARQFVLNRSVTRAVLQGIFGSERVREVQQERCQELTKSFVPLIVNAQSRGEIRGDLPAEKIAQLAVQAYLGVLMSWANEQGEPGLPEQMTLTFEVFVRGISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM53</accession>
    <name>A0A398CM53_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_12225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03525">
        <property type="protein sequence ID" value="RIE03525"/>
        <property type="gene ID" value="D3H35_12225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019457">
        <property type="entry name" value="Uncharacterised_YojJ_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10372">
        <property type="entry name" value="YojJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAC" evidence="6">
        <location>
            <begin position="41"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="203" mass="22388" checksum="FFB9D0A92F7B5750" modified="2018-12-05" version="1">MERGDCDFSPLRLELKEQLSDIHTRMGQIIASLDEGEGCLLNEMEHILSRFTESGALASTYYLRCFLSPYTSKYNEISRSIQHLCAKKQGALLVIQREKPVEPWMTPGIPLAADITSSLLDSIFVPASPLHDGAVYIRSDKIVSAANVLPLTRQSYGEKKLGTRHRAAIGLSELTDALTIVVSEETGKASFCLDGKLFPFSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMP6</accession>
    <name>A0A398CMP6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fic family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_29595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00194">
        <property type="protein sequence ID" value="RIE00194"/>
        <property type="gene ID" value="D3H35_29595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="3">
        <location>
            <begin position="127"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="228"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="268"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="380" mass="43927" checksum="529B93B841F44FDA" modified="2018-12-05" version="1">MTYFFAYEHFDTTEGRLIYKPNLNPYDYEIQQLILEAERNIGALARLGLKNHPLKPTILRNSLVRTAHFTTKIEQNKLEYKEVEQLYQNYKRNPLTIKQKAQLEVKNVFETYEYIYSLEPNKDFTDMDEPVLKKIQHTLMNDLTGYPEGYRNIPVALQDGDGHISYQPPAFNEVPRLMQAYFSWLYTSVTGFLNPYETEKVNLEKKVHPLIISGVTHHLIGYIHPFPDGNGRAARAFSTLVGLIHPDLATIKDAFSVEEFFDKRIEDYYDTLMTATQGNLKPFIVFYLECVNASLTKVLKELQRYDKIKHIRELLGRGHAKTMFELISRMEDGEIFHRQLFDDILAASPSSIAKNISKLKELGVIKSGPSRGEYIVCIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN21</accession>
    <name>A0A398CN21_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_23270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01307">
        <property type="protein sequence ID" value="RIE01307"/>
        <property type="gene ID" value="D3H35_23270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="118" mass="13968" checksum="C9F9DCC248A64DA5" modified="2018-12-05" version="1">MRWSLMNFGEKLTRLREQKGLSQYEVAERLGIKRPRYNAWEQSLAKPRADLLNLLATFFEVSPSYLLGFNEEDTPQQPEPPFEPGTIAAHHEGEDWSEEEQEDIRRFKEFLKSKRINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN30</accession>
    <name>A0A398CN30_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03885">
        <property type="protein sequence ID" value="RIE03885"/>
        <property type="gene ID" value="D3H35_07910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="511" mass="56315" checksum="2DD7E80CBF641FD2" modified="2018-12-05" version="1">MPPKGTKYKQPLLLPNRLASFDRQRKPVAQLPRSDYSINRILLQNIQRKRGVALKSSKASSSLILLLCLLLLSACSQDGKKLKPFDPKKSTRIKIMYDSPGYYDQDYGRYLSAKYPNLEVEVASTDTLFGKPSSEYKKFIQNENPDVLLLTPDLYEEYVLAGKLMPLDELITQDAFDIENIQPFIVEYLKEKGEGKIYGLANSFYSLGLYYNIDLFRKHGIETPRNGMTWEEVAALAGRFPHSGSGDDRVYGLQVDGDYSPALNLLLSLTGTQNLRLVDKDGSKLLLDTASVKSAYEKTVDMLASGSLYADPIDKTLQIGDTLEGFLERDPFLMNKVAMTIRPSWYMSDIRGFSSGPKKHKPASYGVATVPVDPSNPGASAHVGLSKIFCVSASASNPGAAWEFVKYVNGGELAAIKSKTDLPELPARTAAKEDKDGRSLEAFYSLKPNISFHPLTEDVPRAFLLDWDKTVSEQTTAAIEGKISSEAALKSIQSEGQAKLAKAGSAESKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN32</accession>
    <name>A0A398CN32_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000041">
        <property type="protein sequence ID" value="RIE00991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00991">
        <property type="protein sequence ID" value="RIE00991"/>
        <property type="gene ID" value="D3H35_25255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="63" mass="6525" checksum="A39347B3449CBB2A" modified="2018-12-05" version="1">MPAMPGVHAGDGQQIVTAEQFQPRVSKLLASKGGKVLEAPFALTVYLCPSCFAVQHALSKAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN48</accession>
    <name>A0A398CN48_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_10190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03660">
        <property type="protein sequence ID" value="RIE03660"/>
        <property type="gene ID" value="D3H35_10190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="358" mass="39526" checksum="24F8B7383F3ECDE0" modified="2018-12-05" version="1">MKMEDIARLANVSKSAVSLALSGKPGIGAETRERIIQIANEHGYEGKAKAPVSADKLSRSLLFLVFANSGIVLEHYYQQPFFRELIHYIEERCRSKGFTLQFTSVDMESIGSIPAIVEENRSSGVILLGTNLSRQHIADVAEKLPRLVVLDTCFETLPVSFVEINNAMGAYQAGAYLCGMGHRDIGYIASNVRIHNFDARKQGFEAALRENGLEIASERTFAVAPTILSSQEAMKEQFERYLATYGKLPTALFCECDYIAISALKTLTELGQRVPEDVSIVGFDNISEAVIVSPELTTVHVEKSKLAYSAVDLLVEQIETNADVSVKTRVDTKLVQRLSCRAPGQTARPTYEKQPERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN51</accession>
    <name>A0A398CN51_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02218">
        <property type="protein sequence ID" value="RIE02218"/>
        <property type="gene ID" value="D3H35_15890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="95" mass="10874" checksum="22B12C23E365BE78" modified="2018-12-05" version="1">MSEHSGQHSMEPISGEKVTVDGVYKNEWGNEEELKRGQVFPADLALGSTEWELVEFSYENHHEGRTDPRLVPKANDTDQLGKITHPRRQMDRGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN65</accession>
    <name>A0A398CN65_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_28440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00354">
        <property type="protein sequence ID" value="RIE00354"/>
        <property type="gene ID" value="D3H35_28440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041483">
        <property type="entry name" value="TetR_C_34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17929">
        <property type="entry name" value="TetR_C_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="218" mass="25110" checksum="8383E4FE7518C6D6" modified="2018-12-05" version="1">MAKRAMTPEAKALKARTILDKAAEMFLLSEYEKIKMSDIAKQMSMSNGILFVYFKTKEALFFSLLCREYEKRVARLIEIAKDAPIKNFDDFKNLVMNELIELVDHNPLYVRLEAMRTAVFEKNVDAETMLNQKMNLYKLMTDLVTIICEHHALTQEDVVDILQAEASIITGCKLSATLPAEVIDIIEEHGLDGLKRDFKKDVLATMNYYLDGYIKNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNS1</accession>
    <name>A0A398CNS1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methylated-DNA--[protein]-cysteine S-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_08470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03982">
        <property type="protein sequence ID" value="RIE03982"/>
        <property type="gene ID" value="D3H35_08470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="6">
        <location>
            <begin position="91"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="187" mass="20511" checksum="6A7BE3A1B52168D4" modified="2018-12-05" version="1">MEKNAKPNIYWSLLVHDDWSVYIAATEEGLCFVGSHSRAFDELENWSNARFPGSALIRNDEKLQPFAAELIGYWKGTRTSFGISFDLRGTPFQLAVWNALLEIPHGQTSSYSDIARRIQKPAAVRAVGAAIGANPVLIAVPCHRVIGKNGALTGYRGGMDMKTRLLGLERDGADDGHSLGIIFHDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNS8</accession>
    <name>A0A398CNS8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit alpha</fullName>
            <shortName evidence="11">RNAP subunit alpha</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">RNA polymerase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Transcriptase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpoA</name>
        <name evidence="13" type="ORF">D3H35_02380</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05016">
        <property type="protein sequence ID" value="RIE05016"/>
        <property type="gene ID" value="D3H35_02380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00059">
        <property type="entry name" value="RNApol_bact_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02027">
        <property type="entry name" value="rpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLD" evidence="12">
        <location>
            <begin position="20"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha N-terminal domain (alpha-NTD)" evidence="11">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha C-terminal domain (alpha-CTD)" evidence="11">
        <location>
            <begin position="245"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE05016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="314" mass="35229" checksum="1F19364EBA7B1F61" modified="2018-12-05" version="1">MIVIEKPKIESVDIHEDKKYGKFVVEPLERGYGMTLGNSLRRILLSSLPGAAVISVQIDGVLHEFSTIPGVIEDVTEIILNLKRLSLKIHSDEEKVLEIDAEGEGIVTAGDIRADSDVEILNPDLHIATLASGARLHMRIFARQGRGYVPADRNKKEDQPIGVIPIDSIYTPITRVNYQVENTRVGQVTNYDKLTLEVWTDGSIRPEEAVSLGAKILTDHLSLFVGLTDEAKDTETMKEKEEDKKEKVLEMTIEELDLSVRSYNCLKRAGINTVQELITKTEEDMMKVRNLGRKSLEEVQEKLEELGLGLRLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNU3</accession>
    <name>A0A398CNU3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_20180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
            <topology evidence="1">Peptidoglycan-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02929">
        <property type="protein sequence ID" value="RIE02929"/>
        <property type="gene ID" value="D3H35_20180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06920">
        <property type="entry name" value="NEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1850">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006635">
        <property type="entry name" value="NEAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037250">
        <property type="entry name" value="NEAT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05031">
        <property type="entry name" value="NEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00725">
        <property type="entry name" value="NEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158911">
        <property type="entry name" value="SSF158911"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50978">
        <property type="entry name" value="NEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NEAT" evidence="3">
        <location>
            <begin position="431"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="NEAT" evidence="3">
        <location>
            <begin position="648"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="4">
        <location>
            <begin position="818"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="4">
        <location>
            <begin position="883"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="4">
        <location>
            <begin position="941"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="622"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="766"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="804"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1001" mass="107078" checksum="FB4F167159297202" modified="2018-12-05" version="1">MTVTPAVFEERLSAGYSLYDAAVEGDFDGTYPVGSKAALHSKLQLGKSLVEESPGNSVLLDAAYKIVDQAIKTFEASRITVDKSRLSQWLATASAWVTGKADGGTAASGMPSSNHSFADGEYTPLIFKSPAIGYEGPVTQVKNLIVEAQAVLDNVQATQAAVNAMLNKAVSGSDWELFEAQRLSAYDIEIMVLDSIGENAQISPHASDISPHAVMLQQQGPDYYQAYANFVFNNSSQTLTDSSIRQVSAAAATGLFGNNYTSTVARIVNVKKNDLPNLTGTPQYKSVMEQAYSEQEQLTPEPAENPLIATVKVYQSMVRSQNRTYKQTDMLWQGLWKLQYPLELPEAQRKTVFISFNKAYLDELKSLLAEARQLRNSASEGSGAGQHSAYQIGKLQDAIDLADKTATWLAAPRPQILTATNSLQAAIDAFEASASRNVYFSAVDATKPEFSRMETYFQKPAFVATNDDGTLKVTLTIVGSSSVPEFKVKNGNEYVEAATVSENGANDTRVVAFTVNSLSDLLDAQVRTVVPAANYDRTHSIRLNFNNVNNQALYELLQTATAAHQAAVVGTEPGQYPALAKTALANAIALANEEAVRLPAEQSNSAAAQLLLSRALDTFKASYNPTPGTNTPEPGTPNPGTGSGAGYPADGYHHMNFRILKDGSDAASMAYDYVVNQALVEVRGSSRIVKFVVKQSNEIKYFTIGGSSESVISRNSDKNTRVVSFSLPSLTGKLSGTVRIDWDAFNYHHTYDVQFLFNEASAASAGSSPSVPGAESNGNVGVGPDKVDEYKGETPPVDATSEENALPGENTAESGSGTPSIKFTDTSSHWARSSIEQAIKLGIVSGYADGSFRPNSMVTRGEFAVMISRALNLEGEGDTGSLQDFGNIPSWARAHVARAVALGIIGGFEDGTFRSGSQLSRAQLAVIIARAAQLEPDANAKPDFADTVQIPAWAQKEIAAAVKAGLIQGKVGNRFDPNATATRAEALTLIIRLLERNGSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNU9</accession>
    <name>A0A398CNU9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TlpA family protein disulfide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_28020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00584">
        <property type="protein sequence ID" value="RIE00584"/>
        <property type="gene ID" value="D3H35_28020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="115"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="258" mass="28798" checksum="E603243C29057497" modified="2018-12-05" version="1">MRSPWRPPWMWLTARIANAGLLTAQGIISPRLRRPMQEQAKVGTTRRYEVKWESTDKMKHRRKSGVLKMKRNLFILIIVAAAIAAVFVYTNDKGPKASNAGGTAEQGQENDAAKPKPGSKAPAFKLAALDDKLNATYEAGGPRDKVLIVNFWASWCGPCELEAPDLKTLNEKYKDKVDLYAVNATKYDVVRNAKLFVKEHEFTFPVLTDADGKVGDEYKVFSYPISFVIGRDGTIIERIEGVKPLEDWEALLDKAIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNY3</accession>
    <name>A0A398CNY3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">rRNA cytosine-C5-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_27095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00634">
        <property type="protein sequence ID" value="RIE00634"/>
        <property type="gene ID" value="D3H35_27095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="Fmu/NOL1/Nop2p_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031341">
        <property type="entry name" value="Methyltr_RsmF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027391">
        <property type="entry name" value="Nol1_Nop2_Fmu_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031340">
        <property type="entry name" value="RsmF_methylt_CI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17125">
        <property type="entry name" value="Methyltr_RsmF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13636">
        <property type="entry name" value="Methyltranf_PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17126">
        <property type="entry name" value="RsmF_methylt_CI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="7">
        <location>
            <begin position="24"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="112"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="347"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="566" mass="61823" checksum="AA9E8AC17899E67E" modified="2018-12-05" version="1">MALKLPALFITEMNRLLEEEADEFFATYNEPKHSGLRANGLKLTGEALRDLSPLVGPSEIPWADGGYYTSEEIRPGKHLYYHLGLYYIQEPSAMLPAELLGVRPGDRVLDLCAAPGGKTTQLAAKLQGQGVLVTNDNAAERTKALAKNVELAGIRNAVVLNEEPGRIADAFGAWFDRVLVDAPCSGEGMFRKDEDMIGQWERHSVERCSRMQDAILLDAARLVAPGGRLVYSTCTFSPRENEGTIAKFLAARPDFFVVSTDLPASFGFAPGRPDWLNDEEKAGLDEPTIASLAGTVRVWPHRSRGEGHFAALLERRPGDQANQACSATLATDGASIASAAYTAAGTLPPSVLNERDNGTKDQKASNGFLNERDNGTDRRKRGAAPYQAARQKPAPNHRKEAKHPVRVDETEDVLNKFEEFVKVHLNEGRQLPVFQQSGRLLVRGASIYLVPAEVPVLSGMNVVRPGWLLGSATKHRFEPSQAWAMGLTSRDAVRSLRLSSSHPDSLRYLKGETLQPAEADIVGPDGITPVGGKGWTLVCIDGFPAGWGRYDGTLLKNERLPGWRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP12</accession>
    <name>A0A398CP12_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_06735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04303">
        <property type="protein sequence ID" value="RIE04303"/>
        <property type="gene ID" value="D3H35_06735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="187" mass="21020" checksum="A9FEDE77755FD14E" modified="2018-12-05" version="1">MKRYIRAMMCIVTSLIRFGIIKVFNFKNFNFAYLQLISPLCQVEMQRDSKLSLGKMIRARSGSKIRVRTNGEIFIGNNTSFNHGCMLTCYDKIKIGKDVQFGPNVLIFDHDHDFKTPSGLKNLLYVTAPVEIGDNVWIGANVVILMGTKIGNNCVVGAGSIIKGNFPDNTVIVQKRETTVTEYNFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP49</accession>
    <name>A0A398CP49_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03069">
        <property type="protein sequence ID" value="RIE03069"/>
        <property type="gene ID" value="D3H35_21020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="139" mass="15327" checksum="5780521CDCA6A238" modified="2018-12-05" version="1">MKISTKGRYGLTIMMELAAKFGEGPISLKSIAEKNGLSEHYLEQLIAPLRNAGLVKSVRGAYGGYILSKDPETISAGDVIRILEGPISPVDFTEEDDPAKRDLWLRIRDSIAEVLDSTNLADLISYKDAGQPDSYMFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPE9</accession>
    <name>A0A398CPE9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01787">
        <property type="protein sequence ID" value="RIE01787"/>
        <property type="gene ID" value="D3H35_13375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="247" mass="27483" checksum="7CB1F0CCBEDF7EED" modified="2018-12-05" version="1">MVHTFAIEPQTYIAFENEAEQLDKCKEWGLLSDKATKSKAFYYKGNGKNEACSIVGYVDRFVAVIEFDNKQKHCIHPSYLKEMQASSYGQKYAARAESEDLQEQAEAEPELHAVQEEPELTVAEEAPPTKELPAAEEPAKAKAPKTKGKVQLPEEKVKMTATVKEFATVPNHFSDNDDEVVIYEAVAILDSETVLGEAWSSHSATIKKLELAIGDTITFEGKVVAKKLTKHPVPYKINNPAKIQKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPI3</accession>
    <name>A0A398CPI3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04425">
        <property type="protein sequence ID" value="RIE04425"/>
        <property type="gene ID" value="D3H35_07525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="60" mass="6817" checksum="A97B0A707929CB28" modified="2018-12-05" version="1">MRTADQVKRKLNELAGQKKRLEALAAEEGGHPSSDRIARLEDQIFLLEWVLNEPTGSYHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPK1</accession>
    <name>A0A398CPK1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Germane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_01075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000009">
        <property type="protein sequence ID" value="RIE05326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05326">
        <property type="protein sequence ID" value="RIE05326"/>
        <property type="gene ID" value="D3H35_01075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017277508" description="Germane domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Germane" evidence="3">
        <location>
            <begin position="102"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="236" mass="24306" checksum="4ACF8CCAD46AB601" modified="2018-12-05" version="1">MKSSWTRKSRTRLLAAMLLLLPVVSACSLGGGGGEPDVADIDAPPASVEQSMLEQTDEQPSHPSIATVDNAQDGHAVKAGDAAGQAGQAGQVSQEAAGDTVTVYLLDRNGYVAPMTLRTAAESGGKEKGGDNAAGQTLAETALSWMIDNPERRDQLPPGFSALLPAGTKINSVVPDAESRSVTIDFAEPLTAWRRARIERRSSGSANRRNGAGLGVRNDGIDFGAAGSNALNPGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPM3</accession>
    <name>A0A398CPM3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PspC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_18635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02678">
        <property type="protein sequence ID" value="RIE02678"/>
        <property type="gene ID" value="D3H35_18635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="8">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="157" mass="16802" checksum="1B11C5FC3F3DC85C" modified="2018-12-05" version="1">MRRLYRSSRDKKLFGVCGGLAENVGVDANLLRILLVILAVFSGGAVILVYLIAGFIIPRDPYYDGNPPFNGGWGGASNQPPQYGTQGWPPGNQHSGSYSAGATGTAPTSFSSASSSTPRPAQGLDAMMEDVEKKALRREIEELRAKITKIENQSKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPS8</accession>
    <name>A0A398CPS8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aldehyde-alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_24195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01461">
        <property type="protein sequence ID" value="RIE01461"/>
        <property type="gene ID" value="D3H35_24195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008774">
        <property type="term" value="F:acetaldehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08178">
        <property type="entry name" value="AAD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034789">
        <property type="entry name" value="AAD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012079">
        <property type="entry name" value="Bifunc_Ald-ADH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000111">
        <property type="entry name" value="ALDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="6"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-ADH" evidence="4">
        <location>
            <begin position="464"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="869" mass="95124" checksum="A59BF0A15E5ADCB8" modified="2018-12-05" version="1">MAVKENVGAKEVSSQTEVHRLAERARRAFEAYMELDQEQVDKIVQQMALAGLDKHMLLAKMAVEETGRGVYEDKITKNLFATEYIYHSIKNEKTVGVIEDNPYESYRKVAEPVGVIAGITPVTNPTSTTMFKALIAAKTRNPIIFAFHPSAQQSSAEAAKTLLDAAVAAGAPEHCIQWIEHPSVEATGLLMNHPDVALVLATGGSAMVKAAYSTGKPALGVGPGNVPCFIERTADLEQAVTDLILSKTFDNGMICASEQAVILDEPIYDKAKKLMIDNGCYFLNKEETEAVSKLVINPEKCAVNAVIVGQPAVKIAEMAGLTVPAGTKALVAELTGVGEKYPLSAEKLSPVLACYKVKTAEQGIERAAQVVAYGGMGHSSVIHSNDQAVIAAFSARLQTGRIIVNAPSTHGAIGDIYNTNLPSLTLGCGSYGHNSTTSNVTAVNLINVKRVAYRTTNMQWFKVPPKIYFEKGSTQYLEKMPDITRVMIVTDGSMVQLGYAEKVEYYLRKRRTPVAIEIFSDVEPDPSVDTVERGTRVMAQFKPDCIIALGGGSPMDAAKAMWLFYEYPDTSFDSLKMKFLDIRKRIYKYPRLGRKAKFVAIPTTSGTGSEVTSFAVITDKNKGNTKYPLADYELTPDVAIIDPDYVYSLPKTAVADTGMDVLTHAIEAYVSVMANDYTNGLALQAIKLVFENLEASYHKADPKAREKMHNASTIAGMAFANAFLGINHSLAHKWGGQYHTAHGRTNAILMPHVIRYNAQKPTKFASFPKYDHFVADQRYADIARLLGLPARTTEEGVNSLIEAIRKLNRSLGIPESFQAIGFEANDFESRVDYLADRAFEDQCTTANPRMPLVTELADVYRNAFYGKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPX5</accession>
    <name>A0A398CPX5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TIGR00375 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_05565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04585">
        <property type="protein sequence ID" value="RIE04585"/>
        <property type="gene ID" value="D3H35_05565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="373" mass="41056" checksum="C112A5183C0B0121" modified="2018-12-05" version="1">MSIVDKTNANDSLQPLFADLHVHIGRSGDGHPIKISGSRDLTFRSIAEEASDRKGISLIGIIDAHSPPVQEDILRCLDTGEMEEVAGGGIRYRDTVIVLGAEMEIREEGGGPFHLLGYLPNLAAMQEWTEWMRPRMKNVTLSSQRIRVTARELQEELLARGGLLVPAHVFTPHRGLLGCSADRLADRLDPEGIAAIELGLSSNTDMASRISETDRYPFLTNSDAHSTGMIGRECNEIAVAEPSFEELSRALRNEDGRRIVANYGLHPQLGKYHTNVADRIDRLADRGTAPESTARPLYREQVPLNFFPGIGPVLKEKLHDEVGTEMDILHRVPRHALEAAAGEKIAELIWRAREGKLAFIPGSGGKYGRLAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPY4</accession>
    <name>A0A398CPY4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_11810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03359">
        <property type="protein sequence ID" value="RIE03359"/>
        <property type="gene ID" value="D3H35_11810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010368">
        <property type="entry name" value="Com_YlbF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023378">
        <property type="entry name" value="YheA/YmcA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06133">
        <property type="entry name" value="Com_YlbF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158622">
        <property type="entry name" value="SSF158622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="159" mass="18146" checksum="D9F78144A958A870" modified="2018-12-05" version="1">MSAHAHNHDHDHEHGEGCSVPVFDNRDLIVREDIMARAKELAQLITTSEEVDMYKKSERIIQGHEKVQSTIALLKKKQKELVAFQNTFKNAAMAEKIEKEIDALQDELDEMPIVRQFQQSQVDVNYLLQSIVSVIRDTVAEKLDVEAATKLEESEECSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ62</accession>
    <name>A0A398CQ62_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_24805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01571">
        <property type="protein sequence ID" value="RIE01571"/>
        <property type="gene ID" value="D3H35_24805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="71"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="277" mass="30739" checksum="6B67591B0F327BBE" modified="2018-12-05" version="1">MGQRGAPKNMIGVYIVLFALLIFAIFPVYWMLNTSFKSNAEIYRAIPSYWPSNFDFSGYVKLFKGDFVIQLTNSFVISALVSVGSLFVSVLAAFALSRLNFRFRNFFSRSILYAYLIPKSVMYIPLYIFVSLLGLNNSILGLGVIYPTFVIPYATWMLVAHMKSIPVEIEEAAIVDGSSRLGAMFRVVLPLAWPGIITTLIFSFTLCWSEYLYALVIITKEHSKTITLGLASLIVEDVYPWGTLTAGAIIASIPVIILYFVGSRFMVSGATDGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQD5</accession>
    <name>A0A398CQD5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04682">
        <property type="protein sequence ID" value="RIE04682"/>
        <property type="gene ID" value="D3H35_04130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="219" mass="25145" checksum="CD5F75EA34914895" modified="2018-12-05" version="1">MSIIRQWFGTMNEVLDDLILRYPGASGEERFRMQEQWEMLKALSDDMIESWLSFEDKMALYRDLELQQPAPVKAAAAPAPAEHVLAVFQKGQGYFQLHMFGHAAEQLEETVRSHPEFIAGRLYLAMSRMHLKEWNEAQRHFQLISTLTDEPKLIAIAYNALGCIQAIFAQLEQARTYFRKSLETDPSFCDPRRNLESCLNGKGQILLQFGSAELQTICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQE0</accession>
    <name>A0A398CQE0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endotoxin_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_04475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the delta endotoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04743">
        <property type="protein sequence ID" value="RIE04743"/>
        <property type="gene ID" value="D3H35_04475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001897">
        <property type="term" value="P:cytolysis by symbiont of host cells"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005639">
        <property type="entry name" value="Pest_crys_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036716">
        <property type="entry name" value="Pest_crys_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03945">
        <property type="entry name" value="Endotoxin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="SSF51101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56849">
        <property type="entry name" value="SSF56849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Endotoxin_N" evidence="5">
        <location>
            <begin position="27"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="429" mass="48248" checksum="FBC85DA0FD7852E0" modified="2018-12-05" version="1">METNEELKLGFSIDWNTAMKEISVDFSAAIPAIGGAISLLLKIFWPASSENIWDAIKDQVKSLVDEAILNKEMEERNAELNGLRDTMTHYTAAKSNEKGALMANLIGKTDDLYEKLTKSSNQIHLIPFTVAASQLHLIILRERLEHGIEMYKEDNTQQWEEELKTMYNNYFEFFKKIYPQWLSWRSSKIVVNCYTDKNPTTIPPFFYWTSHGEVSDQITGEHLSFSKDWLDSAEYFRPACNAHAERMRNQAIAQMAGTLTTTFGLHRYLKGRENDPPIVDENLKVIYQGPYGGSKLDVTDQPGKIIEINVREWNSIDCIQFIYSDHQGHSIGNPGGGAPHSFSATDSKYFNGIKMKFDKGVMCQIELVYSDGTSSGPLGNRGGWSGQDYDSTVDSAYRLSGGSFTKGNGPSGTVGPSAIRLEYRHHSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRJ2</accession>
    <name>A0A398CRJ2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cobA</name>
        <name evidence="9" type="ORF">D3H35_07930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03889">
        <property type="protein sequence ID" value="RIE03889"/>
        <property type="gene ID" value="D3H35_07930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="HEM4" evidence="8">
        <location>
            <begin position="268"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="516" mass="56346" checksum="8B9D433F118599FF" modified="2018-12-05" version="1">MAKGKVYLVGAGPGDPKLITVRGLEALRKSDCIVYDRLAGPQLLAEARPDAERIYVGKLPDRHTMKQEDINRLLVDLALQGKTVTRLKGGDPTVFGRVGEEAELLKQNGVAFEIVPGITSAISVPAYAGIPVTHRDLASSFSIITGHESPDKLDRSIHWDKVTNATGTLVFLMGVAKVGYISEQLVKHGRSPETPIALVRWGTRAEQRTIVGTLANIEDKVKEAGFKPPAVIIVGDVVRQRETLAWVEDKPLFGMRILVTRARSQASELTNRIDELGGEPYEFPVIETRAVSSETAVQAVRDALLRSETYDWVVLTSVNGVDYFFRWLDECSRDIRDFHRAKFAAVGPKTAEALRIRGVRAAVLPDKFHAEGLLDSLAEELLPGQKALLPHGDLARDVLVRELAGRGVETVGIDVYETTLAVNNDPFLPEMLRDGDIHAITFTSSSTVTNLLEALRRLGAEDPAAWLKGIDIVCIGPITARTAEENGLQVTVTAEHSTIEGLIDALAANRRSKERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRK5</accession>
    <name>A0A398CRK5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sporulation protein YjcZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_02160</name>
        <name evidence="2" type="ORF">D3H35_29055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00456">
        <property type="protein sequence ID" value="RIE00456"/>
        <property type="gene ID" value="D3H35_29055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05195">
        <property type="protein sequence ID" value="RIE05195"/>
        <property type="gene ID" value="D3H35_02160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="35" mass="3466" checksum="4B9502FAAC3EF91B" modified="2018-12-05" version="1">MSGYAGGAGYGGASSAAFVLVLFVLLVIILKAVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRL0</accession>
    <name>A0A398CRL0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_02090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05182">
        <property type="protein sequence ID" value="RIE05182"/>
        <property type="gene ID" value="D3H35_02090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="97" mass="10359" checksum="3A157AFBD05D025E" modified="2018-12-05" version="1">MVDDCTTIQEKLLAATTLLPIGKAGKAIRAAEEAAEAANAGRKMVEKEVAKDVGKGAGNTINGIPKYSLSDVEARTWYLEQESKIPSLLNKNATLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRM9</accession>
    <name>A0A398CRM9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YheC/YheD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05203">
        <property type="protein sequence ID" value="RIE05203"/>
        <property type="gene ID" value="D3H35_01385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026838">
        <property type="entry name" value="YheC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38437">
        <property type="entry name" value="PTHR38437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14398">
        <property type="entry name" value="ATPgrasp_YheCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="259" mass="30134" checksum="600D52BC43CD5C7E" modified="2018-12-05" version="1">MKSTARKNVLSKWLKTKAILKDPKVRRVVPETHRMNEKSLREMLSRYSMVYIKPEAGTYGKGVMRVEQDNGSYWYQKEEKKRAFDSFSSMYRSIVRNKRKRPYLVQKGIHLLKYKGRRFDIRVMVQRNRKLAWEMTGMIGRVAHPRKIVTNYHSGGKPTDVRTLLKAFASGEKLSSIEKNLSKTGYDAAIALSRTYPGLNMVGADIGLDNHLRPWIIELNTNPDPYIFRHLADKRIARKVLSYARALRRIPPAKSKPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS10</accession>
    <name>A0A398CS10_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_13015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01724">
        <property type="protein sequence ID" value="RIE01724"/>
        <property type="gene ID" value="D3H35_13015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="194" mass="22014" checksum="8F52FCB60C9F9410" modified="2018-12-05" version="1">MDKSKADLILHPIRMRIIQSLVSGQRQTTQQLAERNASIPQATLYRHLNTLLKAGLLEVVEERKNRGTVEKVYGLAMNGADLTPDDLTETSSEQHMELFLKFVASLIGDFGAYVGQDRYHMRQDGISFRQHQLYLNEEEYLGLLNGMREQMKEHAGNKPADGRRLRTISTIVIPETRKGQQSADKRETGDESDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS16</accession>
    <name>A0A398CS16_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4956 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05343">
        <property type="protein sequence ID" value="RIE05343"/>
        <property type="gene ID" value="D3H35_00700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032531">
        <property type="entry name" value="DUF4956"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16316">
        <property type="entry name" value="DUF4956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="239" mass="26133" checksum="E31B3B12B5089489" modified="2018-12-05" version="1">MDTNAPTTTTANESTNFSDILKKSVLDNFTSNISPSQIIISLMVAFFIGLFIYILYKRIFSGILYSKSFNVSLIGMTLVTAMVIIAVNSNLVLSLGMVGALSIVRFRTPIKDPTDLIFLFWAAAAGIVTGAGFYSLAVIGSVIIGLVMFVFVKKASFETPYLLVVNCEGDESEKSVHEKLNTHAKRFNVKQKTITEGNIEMTIEVRLKDSEPQFVNEISALGGVRNAVLISYSGDYVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSC6</accession>
    <name>A0A398CSC6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_00430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000005">
        <property type="protein sequence ID" value="RIE05432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05432">
        <property type="protein sequence ID" value="RIE05432"/>
        <property type="gene ID" value="D3H35_00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="102" mass="11589" checksum="A670B8CCE1FC2DB2" modified="2018-12-05" version="1">MGDFVGLKKYIKVFTSDDIMSSMLITFIVTFVGLFISIVTGTLLALWINSKKGFTAYIIQIIVLIPWVISMVVGALLWKWIFNNLGLLNYVLNSLVFRVSMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSE6</accession>
    <name>A0A398CSE6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="14">1.1.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">3-IPM-DH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Beta-IPM dehydrogenase</fullName>
            <shortName evidence="14">IMDH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">leuB</name>
        <name evidence="17" type="ORF">D3H35_10235</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 15">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14 15">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14 15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14 15">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 14 15">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 14 15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="14"/>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03668">
        <property type="protein sequence ID" value="RIE03668"/>
        <property type="gene ID" value="D3H35_10235"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01033">
        <property type="entry name" value="LeuB_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="PTHR42979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 14 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 15" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 14" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14 15" id="KW-0520">NAD</keyword>
    <keyword evidence="10 14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="16">
        <location>
            <begin position="6"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="14">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="14">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RIE03668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="359" mass="38881" checksum="4507C52A5E8EF94D" modified="2018-12-05" version="1">MAEVKKIAVIAGDGIGPEVVAEAEKVLKKTEELFGYQFELEHGLFGGIAIDEKGTPLPQETLDLCKKADAVLLGAVGGPKWDNNSKELRPETGLLGIRKALGLFSNIRPAVVFDCLKDASTLKPEVLEGTDLIVIRELTGGIYFGEKFRRDTENGQEAVDTCVYNVTEVERIVRQGFEVARTRRKKLASVDKANVLETSRLWRETVNRIAPEYPDVEVEHVLVDNCAMQLLRRPSSFDVIVTENMFGDILSDEAAMLTGSIGMLQSASMGEGSFGLYEPVHGSAPDIAGQGIANPIATILSVALMFRLTFGYAEAADVIERAVKNVLDAGHRTGDIAVDKSKSIGTVAMGELIVNAMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSK2</accession>
    <name>A0A398CSK2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02777">
        <property type="protein sequence ID" value="RIE02777"/>
        <property type="gene ID" value="D3H35_19255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="68" mass="6778" checksum="CF169BB52255E70C" modified="2018-12-05" version="1">MPLVDGDVEQSSAAAAAGGMLASGGPFRLGSHTGSGKGRGFIGRVGPAPIFPTTFVFGSGTALRTRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSM2</accession>
    <name>A0A398CSM2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ahcY</name>
        <name evidence="8" type="ORF">D3H35_06430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4 5">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 6">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04249">
        <property type="protein sequence ID" value="RIE04249"/>
        <property type="gene ID" value="D3H35_06430"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="7">
        <location>
            <begin position="188"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="154"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="217"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="296"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="420" mass="45765" checksum="EE32A02809A6F4DC" modified="2018-12-05" version="1">MTTTVQSIVTDLSLAPEGKLKIDWVQAHMPVLNKIREQFERDQPFKGLRVAISLHLEAKTAYLAKVVQAGGAEVVITGSNPLSTQDDVCAALVEDGITVFAKYNPDPVEYKELMVKTLETKPDLIIDDGGDLVTILHAERQDLLVNVRGGAEETTTGILRLKAMEKDGTLKFPMVAVNDAFCKYLFDNRYGTGQSVWDGINRTTNLVVAGKTVVVNGYGWCGKGVALRAKGLGANVVVTEVDAIKAVEAYMDGFTVLPISEAAKVGDYFVTVTGNKDVIRGEHIANMKDGAILSNAGHFDIEVNLVELAALSVSKRVVRRNIEEYVLKDGRKIYVLAEGRLVNLAAGDGHPAEIMDMTFALQALSLRYVNENYEKIGPNVVNVPYALDEQVARTKLEALGIGIDTLSEEQKAYLESWAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTK1</accession>
    <name>A0A398CTK1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioredoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02641">
        <property type="protein sequence ID" value="RIE02641"/>
        <property type="gene ID" value="D3H35_18350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="190" mass="21595" checksum="64D9EC96CC92562F" modified="2018-12-05" version="1">MSSGQQLADKLGKGLKPRQFMESMTKNKEAFASWHEKFAWPDSELQEFFESLNNRDDLRCLILAADWCGDVVRNVPVVFQATETAGIPTEVLIMEDHLDLMDQHLTMGGRAIPVVLFTDTGGVLLGKWGARPQYVQEVMNAFKQANPDREAPDYQEKIAVARQEMMRRYGEDTGYQALILNELRDVLSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTM4</accession>
    <name>A0A398CTM4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="2">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="2">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">thpR</name>
        <name evidence="4" type="ORF">D3H35_08900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04058">
        <property type="protein sequence ID" value="RIE04058"/>
        <property type="gene ID" value="D3H35_08900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014051">
        <property type="entry name" value="Phosphoesterase_HXTX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02834">
        <property type="entry name" value="LigT_PEase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="111"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 1" evidence="2">
        <location>
            <begin position="43"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="2">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="207" mass="22086" checksum="A01E45138CEDDA19" modified="2018-12-05" version="1">MENFRLFVGVAVSNDVIRAMTPILSQLSASLPFKRWTHPADLHVTLHFLGDVAVNRVENLYEAMARIAQTASPFRLQLGELATFGQPDAPRVLWCKVSEPAPAAAASIAASQEDPLASLHDALATPLASAGFALEARPFRAHVTLARNGNAACGPAAIAAAWSEATAQSGAVAPLAWTAERVTVFRTHIGRRPGYERLAEFPLRGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTS9</accession>
    <name>A0A398CTS9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="7">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="7">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">panB</name>
        <name evidence="11" type="ORF">D3H35_04115</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7 10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04679">
        <property type="protein sequence ID" value="RIE04679"/>
        <property type="gene ID" value="D3H35_04115"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3 7" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="7 9">
        <location>
            <begin position="46"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9 10">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE04679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="287" mass="30746" checksum="C8A3BC1606257B63" modified="2018-12-05" version="1">MKQALTIPKLKAMKQQNKPIAMLTAYDYPSAKLSEEAGVDVILVGDSLGNVVLGYDTTVPVTLEDMIYHTRAVVRGAPNTLIVADMPFATYRLGPAETLRNAARLMREGGAHAVKLEGGADLAEEVRRLTASGIPVIGHLGLTPQSVHQIGGYKVQGKDSKEVEKLLDDAKALEQAGAFGIVLELVTEPVAAAISKSLTIPTIGIGAGRGCDGQVLVYHDLLRYGSGIRDKRFVQSYADIGTTIKSAITQYVDDVKSQAFPQEKHGFPLDDQAVQAWSSRLYGGDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU13</accession>
    <name>A0A398CU13_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_11720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03347">
        <property type="protein sequence ID" value="RIE03347"/>
        <property type="gene ID" value="D3H35_11720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="244" mass="25752" checksum="FBEE162F4D71BD4E" modified="2018-12-05" version="1">MSRVALVTGASRGIGAAISIALAKDGADVVVQYRSSPEEAMRVAADIESLGRRSLAIYADLRSSSSTAALKSELDEAGWHPDIVVHCAGVAHYGLFEDTGEQEWDDLLSLHLKAAYRLAKLFAPEMAWRRWGRIIHLSSVWGSVGAAGEAAYSAAKGGLDAFTKSLAKELASSGVTVNAIAPGAVDTDMLASLSAEEKAELARDIPLGRLGRPDEIAELARFVASDSAAYITGQVIRVDGGWQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU70</accession>
    <name>A0A398CU70_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1904 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-oxalocrotonate tautomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02504">
        <property type="protein sequence ID" value="RIE02504"/>
        <property type="gene ID" value="D3H35_17595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015017">
        <property type="entry name" value="DUF1904"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08921">
        <property type="entry name" value="DUF1904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="SSF55331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="157" mass="17453" checksum="0C59060FF680F1DD" modified="2018-12-05" version="1">MPHLLFRGVAPDQIRSFSRALTSELAELCGCGTDNFILECLHTTAVSEQGELVPSFPFVEIAWFERGDETRGRMAEAVDRHIRALGYPEAELAFIAYREDSYYINGVPVAPNPQEELERLRAENGRLKDQLARSRQALLGGAAGGSMSSKLREALRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUE7</accession>
    <name>A0A398CUE7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03477">
        <property type="protein sequence ID" value="RIE03477"/>
        <property type="gene ID" value="D3H35_12545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="260" mass="29711" checksum="67E51165517D0FEB" modified="2018-12-05" version="1">MRIFWKYLILLFKAQMQYRMSFWLLTAGQFIIPFTVFAGLYFLFEHFGQIRGWDFYETALCFGIIHMAFAVSECLARGFDSFSTLVGGGDFDRLLVRPRSTVVQVLGSKFEFTRIGRMAQSVFVLLIAVQGAAVEWTALKIVVLLLMIASGVFIFTGIFMLAATMCFWTIQSIEVANIFTDGGREVAQYPLHIYERWVTRFFTFVIPFGCVNYLPLLYILDRNDGNDLLYAAAPLAGFAFIVPCLLVWRFGVRHYRSTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUG3</accession>
    <name>A0A398CUG3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000022">
        <property type="protein sequence ID" value="RIE04909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04909">
        <property type="protein sequence ID" value="RIE04909"/>
        <property type="gene ID" value="D3H35_03515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="87" mass="9522" checksum="DE4E349322D026F7" modified="2018-12-05" version="1">MTERDALNPSIAALSAATALFVGLLYLKGRGWISNFALLLGMIVGWIVFEWLFPDTAPRHALLRPSFRRSGIRLVSLGSAPGLKLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUQ7</accession>
    <name>A0A398CUQ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000035">
        <property type="protein sequence ID" value="RIE03597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03597">
        <property type="protein sequence ID" value="RIE03597"/>
        <property type="gene ID" value="D3H35_10685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="253" mass="28987" checksum="9B9777AF2149342F" modified="2018-12-05" version="1">MNFNQVSEAQVTLQYEDRDNGVDLIEDVFKLDKDHSEHRFSRVIFKPRKNPYRYRVNYFMKENGKEFKSDWQSGVADKLFINDPFSASRTVSVRGFGDFAARIDSIFVDLVYRDEENNYGSLSPWRSVKRSTSSTGRSGHYRDGRTGDVLREHPLQGRHVRGSSTTVSDRNTIMLGDVALTQSIQLVPDLINFDLVKLVKVTLHYADEANGIDETKDFLFKKGARKRSGSLPTKTNPSKFTNGERLTSWSTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV60</accession>
    <name>A0A398CV60_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04438">
        <property type="protein sequence ID" value="RIE04438"/>
        <property type="gene ID" value="D3H35_07590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="127" mass="14083" checksum="6FF7FC283BE5DCE6" modified="2018-12-05" version="1">MGFDRMLGNLALNHNHKPNGLHHARGALIGLAHLGCLLSPVGDTLVTSSEPNHDIFQSEDESAAAAFEDVLPKSIKKQNDYQVAAGSRLVAKFFDIIHLGSIYIKRPNRQRQVKQGISYMFMLYHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV76</accession>
    <name>A0A398CV76_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05189">
        <property type="protein sequence ID" value="RIE05189"/>
        <property type="gene ID" value="D3H35_02125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="243" mass="26981" checksum="BCF5AE06B3999E69" modified="2018-12-05" version="1">MIPMFRSEWLKIRRSVIWLLVAVSPLIASMFGFMDSGVETGERFPWIEALMMMSILHAMLFLPLLTGIYAALVCRYEHAGGGWKTMLSLPVTRTRVYVVKFAVIMMMLAATQALFLLAVIFVGTLHGFSDPVPWKALLVSVAWGWIACLPLAALQLFVSVAFQSFAAPLAVNVVLTLPNILVVNSDTYAPYYPWAQPMLAMLPREAYGDGAFNTISAALPVVILISFLLFFITGWTYFSKKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV82</accession>
    <name>A0A398CV82_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_17475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03171">
        <property type="protein sequence ID" value="RIE03171"/>
        <property type="gene ID" value="D3H35_17475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="324" mass="36335" checksum="A295E06CB6CADCB0" modified="2018-12-05" version="1">MSLLALLTAAPAAEAHVKWFTDLKPEKETIVNILSPLFMGLAVFVAVLLAVLTQMRPVLADWKLAQKVDRKLDELRSYSVWILKYGLAVALLIQVLSGSLFVPEFDLAAQSDRILLWIAIALLLIPYHLATKAGALVTLWLLVRLTTDVGLFHMLDYGFYLAIVGVLLLEKTKKERWGLPFLYLGTGLSLCWVAVEKWVFPAMALDIVEHHGVPTFGFAPEAFVVMAAFIEFVVGYLLVVGILNRLLSIVLTAIFVSTTMLFGMTELVGHFMIHIVLIIFIIEGVSFYKPPVEMHGRRVDQMIFVSLNFLFVLAAFTLIYYRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVN0</accession>
    <name>A0A398CVN0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ruvX</name>
        <name evidence="4" type="ORF">D3H35_21055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YqgF HJR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03074">
        <property type="protein sequence ID" value="RIE03074"/>
        <property type="gene ID" value="D3H35_21055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="YqgFc" evidence="3">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="137" mass="15325" checksum="7C4F9060EC6703D8" modified="2018-12-05" version="1">MRILGLDYGDRRIGVALSDAFGWTAQGMETIERKQEGDDIRRIGQLVKENDVEAIVVGLPKNMNGTIGPRGEICIEFAETLKRTLSLPVHMWDERLTTVAATRTLLEADVSRRKRKAVVDKMAAALLLQNYLDSRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVV7</accession>
    <name>A0A398CVV7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2487 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04668">
        <property type="protein sequence ID" value="RIE04668"/>
        <property type="gene ID" value="D3H35_04040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019615">
        <property type="entry name" value="DUF2487"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10673">
        <property type="entry name" value="DUF2487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="145" mass="16000" checksum="4095B9A33711EA6E" modified="2018-12-05" version="1">MRFSELNEAEWPDLQPYMDTCLLPVTGLDGTESPWEAKEKVGAAGDWLSPVEYAFKGRTVTMPAYHYYDGGEEALERLRAACRQLKRSGFRYLIIVCGQPNGIAGIPEADLILQPEAEGAAADESLIRKSVSALWKEAAFASDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWF6</accession>
    <name>A0A398CWF6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosome assembly RNA-binding protein YhbY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yhbY</name>
        <name evidence="4" type="ORF">D3H35_05890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04157">
        <property type="protein sequence ID" value="RIE04157"/>
        <property type="gene ID" value="D3H35_05890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001890">
        <property type="entry name" value="RNA-binding_CRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017924">
        <property type="entry name" value="RNA-binding_YhbY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035920">
        <property type="entry name" value="YhbY-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01985">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01103">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75471">
        <property type="entry name" value="SSF75471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00253">
        <property type="entry name" value="RNA_bind_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51295">
        <property type="entry name" value="CRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CRM" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="100" mass="11320" checksum="58076688FB82B227" modified="2018-12-05" version="1">MLTGKQKRHLRSLAHHLDPIFQVGKGGTNDHLVRHIEEAIESRELIKLSVLNNFEGDRDEIAAELADKSGSELVQVIGKTIVLYKQAKEEKNRTIVLPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX26</accession>
    <name>A0A398CX26_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RHS repeat-associated core domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_03115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05128">
        <property type="protein sequence ID" value="RIE05128"/>
        <property type="gene ID" value="D3H35_03115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="167" mass="19123" checksum="B5773E3CEF77D0FF" modified="2018-12-05" version="1">MKARNVWANELLYRQDNTTNQQGYYYYNGHGDVVSIKDGNGNPLNSYEYDTWGNFTSKSETMSNPFTYTGEVYDNETGYIYLRARYYDPSIGRFISKDTYEGQLDNPLSLNNYTYVHNNPLINIDPTGHYCVSADGMNAHSGLCKDDSNKPTRQITKDTSMINALRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXU3</accession>
    <name>A0A398CXU3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_09685</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CpsD/CapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03814">
        <property type="protein sequence ID" value="RIE03814"/>
        <property type="gene ID" value="D3H35_09685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="AAA_31" evidence="9">
        <location>
            <begin position="42"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="234" mass="25566" checksum="63218D998ECE8F7C" modified="2018-12-05" version="1">MSRSSTEAKLVTHTNPSSPLSEAYRALRTNIQFSGIDERIQTLMVASAQSGDGKSTSISNLAIAYAQEGKQVLLIDGDLRKPSLHHMFLLSNRLGLTNVLLGGQSWKQSVRETHVPNLSVMPAGAIPPNPSEILASQKMKTLMDELREHFDIILFDTPPILAVSDGIIVSSMCDGVVIVVNSGKTKYAVAKKLQQSLDRAKARVLGVLLNNVKRKGNEGYYYNYYAYGSNAKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXX7</accession>
    <name>A0A398CXX7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-hydroxybenzoate octaprenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_03920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04647">
        <property type="protein sequence ID" value="RIE04647"/>
        <property type="gene ID" value="D3H35_03920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006371">
        <property type="entry name" value="HB_polyprenyl-transferase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PTHR11048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01475">
        <property type="entry name" value="ubiA_other"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="291" mass="32152" checksum="8E298B306E6B2ED4" modified="2018-12-05" version="1">MIHKLRVILEMIKFEHTIFALPFAYVGAILGAVTMERRLPEWSECGWILLAMVGARSAAMGLNRVIDKAIDARNPRTATRALPAGLLKSAEVLLFIVVSFVLLFWAASQLNTLAVKLLPVAVFMTVIYSYTKRFTWLCHVVLGLTIGLAPLGGWVAVTGEVTWTSIILYLTVALWTAGFDIIYACQDIDFDRKEGLHSIPSRFGIAGGLSIARMMHALTALGFALLLVLTDLSWWYFAGIVISGALLLYEHRLVKPNDLSKLNAAFFTMNGILSAVVFAFTFIDLVLVKAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY59</accession>
    <name>A0A398CY59_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04727">
        <property type="protein sequence ID" value="RIE04727"/>
        <property type="gene ID" value="D3H35_04385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025945">
        <property type="entry name" value="DHHW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14286">
        <property type="entry name" value="DHHW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017483855" evidence="1">
        <location>
            <begin position="34"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="380" mass="43331" checksum="002B45985854D3C1" modified="2018-12-05" version="1">MNKKTDRALAYGFIAALFSMSFAFVALPNQAFSETENRTLQSSPKLTWSNLWSKKFAEEAENYVTDHFPFRDRWVWMKSGLEQIRLQQENNGIYKGKDGYLFEKFAEPDYEKAAKYAEAIKRFAERNPQANATFVLAPTSIGVYAERLPWLASAYPQSKVNAYIANKTEGGPTFLNGDDFLSPDSDKPLYYRTDHHWTTYGAYLAYRAYAKEMGWKPKPESEFDIRTVTSSFLGSYHTKSQFSGLSPDSIQAYLPKQPVKTTAYVADTDETFDSLYAPEYLDKKDKYSYFLGGVHALMEIKTELAPEASSLDKLLVIKDSYAHSVIPFLTLHVPDIHVIDIRYYNGSIDGYMKEHGIRNVLLLFNTATFVDNASLLKLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZG9</accession>
    <name>A0A398CZG9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04324">
        <property type="protein sequence ID" value="RIE04324"/>
        <property type="gene ID" value="D3H35_06895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="69" mass="7657" checksum="37C182AD2CA34134" modified="2018-12-05" version="1">MVLITMSCIVVQKVVRHNTEDREIQLENPKHRKRNTSAFTGMAYAGMVIGFGMFAIGMANAPFELNVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D049</accession>
    <name>A0A398D049_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sulP</name>
        <name evidence="7" type="ORF">D3H35_05475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04544">
        <property type="protein sequence ID" value="RIE04544"/>
        <property type="gene ID" value="D3H35_05475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="431"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="583" mass="62240" checksum="B8269C9AF69FEA10" modified="2018-12-05" version="1">MKWTGRFEGYTPSAIRKDMVSGLIVGIIAIPLGMAFAIASGVKPEYGIYTTIIAGILISMCGGSKFQIGGPTGAFIPILLAIVIQYGYENLLIAGFMAGFLLILMGMLKVGTLIKYIPRPVTIGFTSGISVIIFTGQIGNFLGLRDIEKHESFLLNMKEIGMRLATANIYSIVTGGICLAIILYASKRWPKVPGTLAGLIVSTVAASLLFDGQVATIGSSFGSISSSLPGFHFPELTWDRILALLRPAVIIALLGGIESLLSALVADGMSGTRHNSNRELVGQGIANVIAPLFGGIPATGAIARTAANIKSGAVSPLSGIVHGIVVLLVLLLFAPLASDIPLASMAPILMAVAWNMSERKLFMHILNTKTGDSVVLVLTFALTVFTNLTVAVEAGLVLSVLLFVWRMSQSVTVAKVLPDRSARHEKVKSYMVTEGRDCPQISIYTIEGSLFFGTTNRFEHAVLDAIRKKPGILLLRMSKVPFMDASGEAIMASLVEELEKSGGQILLSGVQPQPLDIMKKTGLLEKIGERWFFEHTGDAIQCAIAHLDVNACLGCQRFAFRECAHLSAVKDGGIPPLQTQLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0K2</accession>
    <name>A0A398D0K2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Adenosine 5'-phosphosulfate reductase</fullName>
            <shortName evidence="10">APS reductase</shortName>
            <ecNumber evidence="6 10">1.8.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">5'-adenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">Thioredoxin-dependent 5'-adenylylsulfate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cysH</name>
        <name evidence="13" type="ORF">D3H35_02405</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 10">
            <text>[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite = [thioredoxin]-dithiol + adenosine 5'-phosphosulfate</text>
            <dbReference type="Rhea" id="RHEA:21976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.8.4.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 10">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.10" evidence="6 10"/>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05021">
        <property type="protein sequence ID" value="RIE05021"/>
        <property type="gene ID" value="D3H35_02405"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043866">
        <property type="term" value="F:adenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011798">
        <property type="entry name" value="APS_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02055">
        <property type="entry name" value="APS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="12">
        <location>
            <begin position="36"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; cysteine thiosulfonate intermediate" evidence="10">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE05021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="230" mass="26786" checksum="85BC7202616B6376" modified="2018-12-05" version="1">MNLLEKEAIIRQKAEEFENASPETIIEWAVQTFPNITFACSFGAEDVVLVDMLQKISPKTDIFYLDTDFHFKETYETRDRMVAHYGLEFVQVKPKITPEEQAAEHGEEMWKSDPNGCCNIRKVEPLTRILSQYEAWITGIRRDQAPTRANAKKVEYDTKFGLVKFNPIADWTSERVWEYIRENNIIYNPLHDNYYPSIGCEHCTRQVMPGEDPRAGRWSGNEKTECGLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0R5</accession>
    <name>A0A398D0R5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-ser_dehydrat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05091">
        <property type="protein sequence ID" value="RIE05091"/>
        <property type="gene ID" value="D3H35_02875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-ser_dehydrat" evidence="1">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="89" mass="9625" checksum="2C4C8EFD75343F39" modified="2018-12-05" version="1">MFTSDGEDSPIGTGRGFVIGHPAITVAWFNEEHGVLHLPPEERGLKVGDKLEIVPVHCCAVVNMLDVINLIDGDQVKDVLPIAGRGRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D2F9</accession>
    <name>A0A398D2F9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05254">
        <property type="protein sequence ID" value="RIE05254"/>
        <property type="gene ID" value="D3H35_01660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="70" mass="7759" checksum="672247816C5D6E4C" modified="2018-12-05" version="1">MRNGMGGPVQQERIQAARRNGRTASASVSRENRRRPVRPKRPFLRDPKSRSVKQPSGSVRIVAGSEFVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D2Y5</accession>
    <name>A0A398D2Y5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000004">
        <property type="protein sequence ID" value="RIE05454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05454">
        <property type="protein sequence ID" value="RIE05454"/>
        <property type="gene ID" value="D3H35_00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="125" mass="13416" checksum="A81C6368191A7B36" modified="2018-12-05" version="1">MAANAKSSSIRSQAGKWKGSPSASSCMTAALCRLDPGNRAKSAAFYPVCATIERARAPGQIGFAKYAQGESVGSAVSVSRQCGSRSAGSARIRKRCRRRFFGLNGLDDWMGFMQKALPMCVWATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CB44</accession>
    <name>A0A398CB44_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_28505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00366">
        <property type="protein sequence ID" value="RIE00366"/>
        <property type="gene ID" value="D3H35_28505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="9"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="135"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="334" mass="36768" checksum="82C328D712E4F867" modified="2018-12-05" version="1">MTKLRIGMISFAHSHAYDYLDILSDMPQVEVAAISDDVPQRSELLAASRSIPYFSDYRELLADRTIDAVVICSENVRHAELTIASARMGKHVLCEKPLGVSLEEMERMISVCAEEGVQLMTAFPCRFLTPVVRAREALKRGDIGDIIAFKATNRGSFPDPAWFADRALSGGGAVLDHTVHVMDLMNWFTGSLVETVYAYADTMFDPEGTRTIDDSGMVHITFANGVYGVIDPSWSRNPGFPTWGDVTMEVIGTRGVISIDAFNQKNNVYSRKSGKGEWSFWGDDMNALMLEAFVRALLEGTEVPVTGVDGLRSTEVALKAYQSAYAGMPVLVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBX5</accession>
    <name>A0A398CBX5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS3 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_30005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00280">
        <property type="protein sequence ID" value="RIE00280"/>
        <property type="gene ID" value="D3H35_30005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="195"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="355" mass="41147" checksum="96815E10ED2C07FE" modified="2018-12-05" version="1">MVQLYESGKSRASLVKEYDLTASALDRWISQSQRTGSFAAKDNRTPEENEMLELRKENQRLKMENDIFKASRADYGTKVNVIRNNAHKYSVSAMCSVLQLPRSTYYYEPVPAPDLQEQQLEEVVIEIFKSSRNNYGTRKIKVELTRKSLQVSRRKIGRVMKRHGLVSTYTVAQYKPHKAAPNEAEIGNVLQREFSQEKPLAVVVSDLTYVRVDAKWNYVCLFVDLFNREIIGHSCGVNKTAQLVYDAIASVSVRLDRIQMFHTDRGSEFDNKLISEALETFEIERSLSNKGCPYDNAVAEATFKIFKTEFVKQRHFHNLQQLQLELDDYVHWFNHHRIHGTLGYRTPVEARQWPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBZ4</accession>
    <name>A0A398CBZ4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000060">
        <property type="protein sequence ID" value="RIE00303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00303">
        <property type="protein sequence ID" value="RIE00303"/>
        <property type="gene ID" value="D3H35_29355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="12"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="106" mass="12517" checksum="C43808CD287C2783" modified="2018-12-05" version="1">MIRMNSTKSKIKDIYPLTPMQQGMYFHSLKDKDSGTYFDQVCFDIEGNLDTALLEQSINKLIERHDILRTIFSNKSKQVLQIVWKERPLKVFFENLNGWESTNKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCS6</accession>
    <name>A0A398CCS6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00986">
        <property type="protein sequence ID" value="RIE00986"/>
        <property type="gene ID" value="D3H35_25475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="66" mass="7071" checksum="476C90DFACC4FC2C" modified="2018-12-05" version="1">MNQLKELQKLIKLTGDRAKLDAKANETYIVYKTAAGQIVKEFSNGNIVPVTGPEDPLSVGIPSSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCU3</accession>
    <name>A0A398CCU3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00523">
        <property type="protein sequence ID" value="RIE00523"/>
        <property type="gene ID" value="D3H35_27650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="147" mass="15181" checksum="AF442F690E23F093" modified="2018-12-05" version="1">MNKVSVVLGDLARVGQVTGSAIRGFGNLAGYRWVTGNADGGFGDLARFGRVTGSAIRGFGNLAGYRWVTGNANGGFGDLARFGRVTGSAIRGSGNLAGYRWVTGNADGGFGDLVRFGRVTGSAIRGSGNLAGYRWVLLATWTEVSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCZ0</accession>
    <name>A0A398CCZ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000061">
        <property type="protein sequence ID" value="RIE00285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00285">
        <property type="protein sequence ID" value="RIE00285"/>
        <property type="gene ID" value="D3H35_29370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="84" mass="9262" checksum="1E185FADD9614388" modified="2018-12-05" version="1">MKITESDTIPPAPAVEMTTEADNNEALISWKLQGDPGISLKFRRYTRRKGLRGRNGDRGSCGSEVCPAGRLSGSTTYEIEVRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCZ2</accession>
    <name>A0A398CCZ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_21645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01046">
        <property type="protein sequence ID" value="RIE01046"/>
        <property type="gene ID" value="D3H35_21645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Elp3" evidence="7">
        <location>
            <begin position="176"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="418" mass="46578" checksum="7709837ADD730E39" modified="2018-12-05" version="1">MHLVYADEHGNVFDHPHLHGIARSGDNLVELLEDELIPLPEGATLVGLPHTRAIGMDPKTGEMKPLAGDYQAVGALLPQGFTRFYVPGYMKTDKTQKFPLFGYTAVVWKDGRFYAAAGQSDDPEPWNPENCDRRELKVQVDRLLQTYPDNRLYQHLSHCALTYECLTASNTFLQRLEGAVPVSFSCNAGCYGCISEQPDDSGFVAPQTRLKFKPTVDEVVDIMLEHLKAPEAIISFGQGCEGEPSTQAKTIIEAIQRVRAQTSNGYININTNAGLSDHLRAITDAGLDLMRVSTISALDDHYNAYYMPRGYTLKNVEKSLRYATDKGVYTSINYLVFPGVTDREEEIEAMIGFARRTGLKLIQMRNLNIDPDAYLNLIPKAQGEIYGMKTLLDIFREELPDVVIGSYTHVPPRPVGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDK1</accession>
    <name>A0A398CDK1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex</fullName>
            <ecNumber evidence="6 11">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D3H35_26290</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA</text>
            <dbReference type="Rhea" id="RHEA:15213"/>
            <dbReference type="Rhea" id="RHEA-COMP:10581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10582"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="2.3.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="11">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms a 24-polypeptide structural core with octahedral symmetry. Part of the 2-oxoglutarate dehydrogenase (OGDH) complex composed of E1 (2-oxoglutarate dehydrogenase), E2 (dihydrolipoamide succinyltransferase) and E3 (dihydrolipoamide dehydrogenase); the complex contains multiple copies of the three enzymatic components (E1, E2 and E3).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="6 11"/>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00710">
        <property type="protein sequence ID" value="RIE00710"/>
        <property type="gene ID" value="D3H35_26290"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 11" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="13">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="14">
        <location>
            <begin position="118"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="139"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE00710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="415" mass="43892" checksum="58BBECD616044E3E" modified="2018-12-05" version="1">MSEIIVPAMGESITEGTISKWLVKVGDQVNEGDLLLELETDKVNMEISAEQAGVVQQILNQEGDTVQIGQVVGLIGAGSAAAAPAAPAAEAPKASAPAAPAAAQPAAIAATEAEAIPSASPAARKLAREKGIDLSKVASSDPLGRVSQGDVLNHGTAPAAPAAPAPARQDKPAAAAPLAIPGKPAERKKMSRRRLTIAKRLVEAQHNAAMLTTFNEVDMTAILDLRKRRKQSFLEKFEVNLGFMSFFTKAVVGALKKFPLLNAEIDGEDIIVKQYYDIGIAVAAKEGLVVPVVRDADRLGFAEIERTIGQLAGKARSNSLELSELQGGTFTITNGGVFGSLLSTPILNAPQVGILGMHKIQLRPIAIDQERMENRPMMYIALSYDHRIVDGAEAVQFLVKVKELLEDPEALLIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE43</accession>
    <name>A0A398CE43_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00900">
        <property type="protein sequence ID" value="RIE00900"/>
        <property type="gene ID" value="D3H35_25335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="229" mass="24863" checksum="626B88519803DE27" modified="2018-12-05" version="1">MSSLSTTRLWKSESGSFSIESTLVFPIILTVMLLVVVFAAWTADRAIVYFRASAAAERIAFNWSNSSKAFATGAYPDGRYDGLYRRLFEDAALARLFGIAAGNDGETTVAFPANVPSDDEDLSRRKLREGSRDLGIGMRGELRYRNDLLWGLIVAEAGGLSLYAPIAKFRGKDADASSAARAVSVEPAESVRSFDLIRYYAAKIRSSKEGEPAYRGKAAAIVGRLGVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE62</accession>
    <name>A0A398CE62_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000041">
        <property type="protein sequence ID" value="RIE00993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00993">
        <property type="protein sequence ID" value="RIE00993"/>
        <property type="gene ID" value="D3H35_25270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="116" mass="13139" checksum="DB7C3EC34ECC5BCF" modified="2018-12-05" version="1">MAAILCPWCQSEIPVEEGQGPDKFCPVCDNEIDGYRTLRIGIDEEDEEDEEDGDSVGLVRAEDEEDLSWMQDDELQEKDEALIQFEEAVEELLDEQEVVPNARNAGSTCWRRGSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE68</accession>
    <name>A0A398CE68_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage III sporulation protein AD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spoIIIAD</name>
        <name evidence="2" type="ORF">D3H35_26430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00735">
        <property type="protein sequence ID" value="RIE00735"/>
        <property type="gene ID" value="D3H35_26430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025664">
        <property type="entry name" value="Spore_III_AC/AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014211">
        <property type="entry name" value="Spore_III_AD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06686">
        <property type="entry name" value="SpoIIIAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02849">
        <property type="entry name" value="spore_III_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="129" mass="13850" checksum="BBC5B618B3B8B9A5" modified="2018-12-05" version="1">MDILQIVGIGLLTTVLILVIREQKPMFAFLLAAFLGVAIFLSLIGKIDNVVSVLEELADRSGIPAVYLKTMLKIIGIAYIAEFGAQIVRDAGMESIASKIEFAGKILILVMAVPIISVIIETVLNLLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEC2</accession>
    <name>A0A398CEC2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00980">
        <property type="protein sequence ID" value="RIE00980"/>
        <property type="gene ID" value="D3H35_25825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017308894" evidence="1">
        <location>
            <begin position="27"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="115" mass="12881" checksum="AEA49B7F15F680A0" modified="2018-12-05" version="1">MIRAKGKASKWLGIAASVFLVSAIFAAGCSKNGNDEAGTKDFVELSWYMSKPIDNEKDQAAVEEEANKVFKEKINAKLHFNLIDNAGWEDKMKLMSGRAKRTILFLRPRTRTVCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEF3</accession>
    <name>A0A398CEF3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-phytase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_29805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00232">
        <property type="protein sequence ID" value="RIE00232"/>
        <property type="gene ID" value="D3H35_29805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:3-phytase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003431">
        <property type="entry name" value="BP_Phytase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02333">
        <property type="entry name" value="Phytase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51662">
        <property type="entry name" value="BP_PHYTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017210384" evidence="1">
        <location>
            <begin position="26"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="BPP" evidence="2">
        <location>
            <begin position="114"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="465" mass="50038" checksum="89E221F0062B09BF" modified="2018-12-05" version="1">MFPWKSAVSSLLIASILLPAGIASAADTSVQGYEPLRKQMDAIGASITWDSDDQSALVKLKNGLAGTFTVGEQEYRLAGKRGELKGEVKLVKGKMYVPSELLQAILAENKKYADPKDAIKPYSVTAQVETAAVEDGEDAADDPAIWLDPANPANSKLIATNKGGGLLVYDLNGKELQSLKVGKMNNIDVRYGFPLGGKKVDIAAATNRSKNTVDVFVINGSTGELTDAVAEPIKAKMEEVYGFSLYHSLKTDKFYALVLGKEGEFEQYELSDNGKGKIAGKLVREFKLPTQSEGLVADDEYGFMYIAEEDYAIHKFSAEADGGSKSVATVDIADGRRLQDDIEGLTIYYAAEGHGYLIASSQGNDTYAVYDREGNNAYITSFKIADGQATDGTSVTDGIDVLGFGLGAQFPNGIFVAQDDSNMNGNKELNQNFKVVPWESIAKGASSPLRIDNAVDPRKLVLRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEG8</accession>
    <name>A0A398CEG8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Histidine biosynthesis bifunctional protein HisIE</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">Phosphoribosyl-AMP cyclohydrolase</fullName>
                <shortName evidence="15">PRA-CH</shortName>
                <ecNumber evidence="15">3.5.4.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">Phosphoribosyl-ATP pyrophosphatase</fullName>
                <shortName evidence="15">PRA-PH</shortName>
                <ecNumber evidence="15">3.6.1.31</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">hisI</name>
        <name evidence="15" type="synonym">hisIE</name>
        <name evidence="17" type="ORF">D3H35_21450</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5 15">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 15">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 15">In the C-terminal section; belongs to the PRA-PH family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 15">In the N-terminal section; belongs to the PRA-CH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="15"/>
    <dbReference type="EC" id="3.6.1.31" evidence="15"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01020">
        <property type="protein sequence ID" value="RIE01020"/>
        <property type="gene ID" value="D3H35_21450"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11534">
        <property type="entry name" value="NTP-PPase_HisIE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01020">
        <property type="entry name" value="HisE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01021">
        <property type="entry name" value="HisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01019">
        <property type="entry name" value="HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023019">
        <property type="entry name" value="His_synth_HisIE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026660">
        <property type="entry name" value="PRA-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 15" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11 15 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRA-CH" evidence="16">
        <location>
            <begin position="35"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosyl-AMP cyclohydrolase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosyl-ATP pyrophosphohydrolase" evidence="15">
        <location>
            <begin position="126"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RIE01020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="220" mass="24809" checksum="C2BC0E358A5F1DB0" modified="2018-12-05" version="1">MTQEQSQSLLDQVKFDAHGLVPAVVQDAISKEVLMLAYMNRESLLKSLESGQTWFWSRSRGELWNKGATSGHTQQIVSLSYDCDGDTLLVKVKQQGPACHTGAYSCFYRDAEGGGIAPEADRFGPLSRLEQTIAQRDAERTEGAYTTYLFEKGLDKILKKVGEETAEVIIAAKNRDSQELRSEAADLIFHLMVLLREQQIPFDDVLQELEFRHRKPVKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEL5</accession>
    <name>A0A398CEL5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_29350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000060">
        <property type="protein sequence ID" value="RIE00302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00302">
        <property type="protein sequence ID" value="RIE00302"/>
        <property type="gene ID" value="D3H35_29350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="3">
        <location>
            <begin position="19"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="391"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="653" mass="74821" checksum="D2E3ED62829A42CA" modified="2018-12-05" version="1">MERKTTQSFFREFEWLGIDQQNTIIINYKQKSKVQGFDLGKDQLMRFALFQREKEKYTMVWCFHHILMDGWSRPIVTEELFAIYRSLSQQESLSMLPTIPYSRYIQWLESRDQQRALQYWKDYMQGYENVVSVPMKENKANCPFLLEETELVLNTEWTGIVTELTKQLQVTVNTWLQTIWGVLLQKYNGVDDAVFGSVVSGRPSEIAGIEQMIGLFINTIPVRIQSRPGMSFSDLVKQVQLSSLSSAQYDYYPLYEIQANSPLKQGLVNHVMVFENYPIGEAIEQSSGQSIGFTISNVETFEQSNYDFCVTIVPGNEIRIKFSYNAARIDRGMVARIRGHLQEVIGQVLETPHVHIDQLEIVTEEEKRQLLHEFNDTKASYPADQTIHGLFEEQVKKTPDHTAVVLESESLTYAELNGRANQLARVLRGKGVGADRIVGILAERSLEMIVGILGILKAGGAYLPIDPDYPAERIGYMLEDSGADILLTQKRLEAKTMGFAGEVLHVDDERLYALDDTNLEHTGSSKDLAYVIYTSGSTGKPKGVMIEHDNVVRLFFNDRTPFQFSYKDTWTLFHSFCFDFSVWEMYGAILYGGKLIVVPKEVSKNPREFLTLLRTEKVTVLNQTPTYFYQLVEEDRLQAEPLLLRMVIFGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEN6</accession>
    <name>A0A398CEN6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3533 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01173">
        <property type="protein sequence ID" value="RIE01173"/>
        <property type="gene ID" value="D3H35_22490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="382" mass="41977" checksum="D6DB59E052108B3B" modified="2018-12-05" version="1">MIHGIKKFLLAKTTIAAIGVAIIYQFIMIGVVLPGYSAMPKNIEKLPIAIVNEDNEQGNEIVNQLKEKLPLKIVEGYSLIEAENALDKRELYLIIHIPEDFTANLTKQDKQVTINFHINEASQALVSSTVKMIATEMSSTFGAQVQKDMMKGVFAQMQMPEEQANAKAEMVATKFNANVIETNEVRDGMHNRLAPLFLNVANNVSAMMVSLILVKSLNRLRPLIGKWQSFIGLIIAVVIVAVLAPLGGLGIFFSIENYGADTFFTMWAAHSLIVLASTLIFLISTMLFGEIGMLINMGFVFTQIVSGTGILPREMLYNIFDVVRVVSPMYYAVQADFTTLFGGSQLAPYLLGLVLLAAGGLFITACIHACIPEDREPRPSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEW3</accession>
    <name>A0A398CEW3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_12970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01716">
        <property type="protein sequence ID" value="RIE01716"/>
        <property type="gene ID" value="D3H35_12970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="84"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="308" mass="35061" checksum="B31EBE48ADD72E97" modified="2018-12-05" version="1">MKAQNIEGNYKANRGGKRFSEWNSYLFLLPALAFMAVFILYPILYNAVLSFKDVNVYNLNGEQHFVGFSNYVKTFKDEVFYIATQNSVIFTIISIFFQFTIGFALALFFNMKFPGRSLFRSLMLLAWMLPVVITGTVFQWMMSGDYGVINYFLQSLGLIDKPVNWLSEGNTALLGTIFANVWIGIPFNMIILLSGLQSLPLQLYEAARLDGANRWLQFRHVTLPLMRPTILVLLMLGIINTFKVFDLIYIMTAGGPVTSSTVLPIYAYQLSFTMFEFSQGAAVSMIMFVLLILVAIVYLRMSNKEEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEX7</accession>
    <name>A0A398CEX7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01736">
        <property type="protein sequence ID" value="RIE01736"/>
        <property type="gene ID" value="D3H35_13080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="143" mass="15941" checksum="0AFBE89A33FAD3A7" modified="2018-12-05" version="1">MNKTILSYLITVVGVAILAVGVYFIKTIEDPQGLLRALPYICVGLGSGMFGHGMGEIMVRYAMKHNPAAAKQLEIEKKDERNLAIANRAKAKAYDMMVFVLGALITALALMDIDLTMVLLLVCAYLFIIGYGVYYRFKYFKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF50</accession>
    <name>A0A398CF50_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ugpC</name>
        <name evidence="6" type="ORF">D3H35_21530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01035">
        <property type="protein sequence ID" value="RIE01035"/>
        <property type="gene ID" value="D3H35_21530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="373" mass="41621" checksum="696B18702A2FE18D" modified="2018-12-05" version="1">MAGVRLEHVFKKYPGTDKASVTDFNLDIQDKEFLVLVGPSGCGKSTTLRMIAGLEEISEGKLYIGDRVVNDVAPKDRDIAMVFQSYALYPHMNVYQNMAFGLKLRKFRKDEIDRRVREAARTLEIEHLLERKPKALSGGQRQRVALGRAIVREPQVFLMDEPLSNLDAKLRTQMRANISKLMKRLETTCIYVTHDQTEAMTMGDRIVVMKDGFIQQAATPEVLYNHPVNLFVAGFIGAPAMNFITGQVAEEGGAVRFRATGVNVEIPEGKAKVLRSKGYVGKELILGIRPEDIHEEPVFIEASPNSVINASIEVSENLGHEMFLYLTGLGKDSVIARVDGRSGLQEGQNVKLAIDMNKIHVFDKDSELNIFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFF3</accession>
    <name>A0A398CFF3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_22315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01145">
        <property type="protein sequence ID" value="RIE01145"/>
        <property type="gene ID" value="D3H35_22315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="309" mass="34608" checksum="76997577B83D73FA" modified="2018-12-05" version="1">MQQEEVVLKLRNVTKKIGNRRIVDDLSFDVPAGEVFGFLGPNGAGKTTTIRMIVGLISMTQGEIAVKGISVRKQFELAMTHIGAIVENPEMYKFLTGYQNLVHFARRHSGVTKERIEEVIKLVGLQNRIHEKVKRYSLGMRQRLGVAQALLHRPSVLILDEPTNGLDPAGIRELRDYLRKLSREEGIAVIVSSHLLSEMELMCDRVAIIQAGKLIDVRSLQETADEAKPYKIAIDVNDPRRAYELVSASFQNANVSLQGNRLELVTDRARIPDIARLLVNAELDIYGIHATQKSLEDQFLEMTGGEMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFQ7</accession>
    <name>A0A398CFQ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_24700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01553">
        <property type="protein sequence ID" value="RIE01553"/>
        <property type="gene ID" value="D3H35_24700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="337" mass="37323" checksum="8CA30106EC1276A2" modified="2018-12-05" version="1">MSKYKWLGIIAILLVVLNGFLIMHLYKKISGSSDSNHYVAQGQVNNLTTGNTDVKNALDYLEIQSDLSQGFKEYALSDFKSKNTMSIKINKMALSKQGNDIILKANLLNDSASNVNWILVNIQLYNAVGHNIGLVPYTILSSQTGDKPLEPGKEITLNHTFDGESVEEWDGRFSVDVLTKNSDSSQTSSQSNAEPKKKEINEKVSKEDQIESAITDAVSELNGIEIYQRDGRYVVEATYDLEDGPYLKSAAEKVARDFTFAAYATGLPILRTSIIINKPDRIVGLTVTVGSAQANTQPESTWSDSKIGPTIFMDWVKQNSNDDYNNLGNHTVAKYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFX7</accession>
    <name>A0A398CFX7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid--ACP ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_26880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00812">
        <property type="protein sequence ID" value="RIE00812"/>
        <property type="gene ID" value="D3H35_26880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="6">
        <location>
            <begin position="145"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="386" mass="44060" checksum="7C14264481CF3091" modified="2018-12-05" version="1">MKGGRTLTFRYHTSDKLTNLQAQSLVSKLTYSLEGISACYLDGENQDIVIHANDDSNRSQIEDTVLLLMEQERTIRTLKSRVIRNVSTNDDNYKSPFPGASYHPDWSFASDGSVRRDFAVMLYQSIDGILSNLAMERHAKYRKYPSMIPLKTLDKCGYVTTFPQNIYLVSEIPHQSDILQKIKKTGDVESNLRQSQYALSPAVCFHCYEELAGQTLEHPVILTALGTCYRHEATWRLGNQRLNEFSMREVVLIGTPDFVESERNWWVDCIWKLFGDLGLTGRIETANDPFYFSDDAAKAQHQQMANMKYELVVEVDGGTQTFSIASFNNIREALCKPFRITDAADKPLHSGCIAFGIDRWVFSLLKKYGEDPGKWQPHIAEMMRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG31</accession>
    <name>A0A398CG31_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_24190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01460">
        <property type="protein sequence ID" value="RIE01460"/>
        <property type="gene ID" value="D3H35_24190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006276">
        <property type="entry name" value="UspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="4">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="141" mass="15354" checksum="61497E713803FA00" modified="2018-12-05" version="1">MFNRILVAYDGSELSRKALDKAISLATEQGASIVAAHVYQLPVFVIGQGYALPNDFLVQMRERARQNVAEAEKLLDRLPNSKAVLLEGVPDKEIVEYAEANGIDLIVMGSRGLGAIREMVLGSVSHRVVQHAKASVLVVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH27</accession>
    <name>A0A398CH27_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02053">
        <property type="protein sequence ID" value="RIE02053"/>
        <property type="gene ID" value="D3H35_14915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="316" mass="33048" checksum="713BA8E4EC771996" modified="2018-12-05" version="1">MRAVLYAVLTEEGWVPGWSVAWEVDLGYWLEEEFRAGVRSEGTGFAGAGIKGRAMARLKEPIPLGLAEAASDWLAERFEVHGRKRDKSQKGIRDGSLEGLRKEERRSLEENGDRAYSENVEELLQEALRAAYFAESGGSAGLTTERSSSKADVFGNLSMAMETMLCSAGGNGSREGMFEEGRTLAKFARMASERLQGRSLLQEEAAPLLAQALPAGGGFAAAKRALQLAALLGAVRLTAAVAPQPLQAPGRGRCDAPSARFSPARLAAAGPCLCAAAVAAAAQRSCGAHGAPLAGGDALTAKRALRWGGAANAGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH86</accession>
    <name>A0A398CH86_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_17990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02576">
        <property type="protein sequence ID" value="RIE02576"/>
        <property type="gene ID" value="D3H35_17990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="56"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="184" mass="20778" checksum="EBD02895DA00E78B" modified="2018-12-05" version="1">MPLSIYSKLPVFSYFLLLCYDERSGKSANDDEKDEWRGAGLDEHRKEWNTSLVRLSNRLADLERLHVSLEEIGARSAWPERIIRDLTLAAEELLTNTISYGFPGGGEQEIVMTVHAAAGFIELSLEDGGVPFNPLESEDPDITLGVDERRIGGLGVYFAKQLVDSMEYERTPGGRNRIRLRKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHC7</accession>
    <name>A0A398CHC7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF1328 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_18155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02606">
        <property type="protein sequence ID" value="RIE02606"/>
        <property type="gene ID" value="D3H35_18155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01361">
        <property type="entry name" value="UPF0391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009760">
        <property type="entry name" value="DUF1328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07043">
        <property type="entry name" value="DUF1328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036466">
        <property type="entry name" value="UCP036466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="54" mass="5985" checksum="ADFA2BE8F209FB34" modified="2018-12-05" version="1">MLYWTMVFLVVAIVAAIFGFGGIVAAAAGIAKVLFFIFLILFVISLFTGRRSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHK3</accession>
    <name>A0A398CHK3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FecR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_28045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00589">
        <property type="protein sequence ID" value="RIE00589"/>
        <property type="gene ID" value="D3H35_28045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017381755" description="FecR domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="3">
        <location>
            <begin position="67"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1115" mass="122018" checksum="8959941FC7F55E77" modified="2018-12-05" version="1">MSKKSSLTFMAFLLVAIPFLGVFARDTYAATSRVGIIKELTGTVEVKKSGGTKQFKAYKKMSLNEGDVLTVGPKSSAVLQFSNGSSEDDRVTAGAGSTLTFSKLTDRGGTTTKISLLSGTTWSEIKSIKSKDDAFTIETPTAIMGVRGTHLFATVDPLSGSTLTMVASGFANVAKKTNGSARPNGGNPTTTIYPTQQIIVDVQGSSQEMDDSVTFLDVDEIINHASPEVIEQFIRNKAQIDKENEELIKKKKADLESLLNRTPGLNVGSPEELDKLMKNVSNLIGALAKDAIDKGKLTAADIERLAKEAGTSIDLRNTELELSKLEQDKLNKEKEKLAELQKKKQEEAKKEKEKLNEQVQAALEAQRRAQEAANKAAESEIKKKALEEYERQLSELEKKRLEQDRQTNGEVVPSPTTGTGSGTGNGGSSAFYGIKYNIIGSGTANEWVKALPFGALQSDYSLEVPFGAIYAVVSPRLNATTTVSTVRYSEDGGESEMSYYATFDETMGGYIVPLIFEHTYIAISGIKADNSSVFVGVALTKRDQPEGLASSSQQYNELSGSGITWNPFEWEYGYGGIFGARVPSESTDLKWTLQLTGGAVKAVVKQITYSGSETEVLSPVTMMSNVETLFTISSKYDYFLVELFDANNHQVGHPIIYWLIDDDIVFGEDDHPFDLKDSSGNAVDYRLGNSESRGFQARVDASVNELRFYSAEGTDLTLEKAIVFEESDYNSDEYYPNNAGVITVPLTNESTSLMVEMKDIGGGSHYYDLIVHRYDLPQGVADWHLIDDLDEEMIWEQARNLPSGSPKRFVASVSGDSSWTDLHFDPTSGSELKLYDSYGELVKTFTAEEPEYRVEFNGNGYYRFKLMNGTKATEFVIERGFVSSQLDENEFLINQAGNERVTIPTYNYEGDDFEKGFAVVTDDIANPIMFALDSDFGDIELRTDNSAVHISEPDGDGYRTLNFSEPGTYDVSVEVHSPLDYSDATKYLLTVYYGSVPAAIDLTPSQIAYAGGTVNSVTYLGSYTYQINMTQGLTQNPFVDLTLSFSGTIKGFSSDDGMTASQAGAAYILYGVQAGASKSIYLTVENGTDIELPMYSFSKSASRCRKKVGEGELIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHL0</accession>
    <name>A0A398CHL0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CxxH/CxxC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_24320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01482">
        <property type="protein sequence ID" value="RIE01482"/>
        <property type="gene ID" value="D3H35_24320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025626">
        <property type="entry name" value="YyzF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14116">
        <property type="entry name" value="YyzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04129">
        <property type="entry name" value="CxxH_BA5709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="55" mass="6397" checksum="05167AF33F9C9257" modified="2018-12-05" version="1">MYCVCREHVEQAIDKFVDEYEDAPDLVNLQTTVFSAWKPPEHCEWCGKPVEVLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHX3</accession>
    <name>A0A398CHX3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02393">
        <property type="protein sequence ID" value="RIE02393"/>
        <property type="gene ID" value="D3H35_16930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019825">
        <property type="entry name" value="Lectin_legB_Mn/Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00307">
        <property type="entry name" value="LECTIN_LEGUME_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="163" mass="18962" checksum="0BAA8A57818C0653" modified="2018-12-05" version="1">MEQNSRKWRLEQLLQQQKSKQNISYGLLFEECIEALGEEVVIFSERTSERIRSELTTAYPFTSWGRIDWNNTTSRHDLRIAIDSIPVLKSKRLDTEAPIYIIWGGNYPVLQTKLQKVLSALDDVLAVDFDTFAYCPSNYVIEFYHEGEITLGIERLDNFEHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI84</accession>
    <name>A0A398CI84_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">modA</name>
        <name evidence="5" type="ORF">D3H35_15540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02160">
        <property type="protein sequence ID" value="RIE02160"/>
        <property type="gene ID" value="D3H35_15540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13537">
        <property type="entry name" value="PBP2_YvgL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041879">
        <property type="entry name" value="YvgL-like_PBP2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004846">
        <property type="entry name" value="ModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017436300" evidence="4">
        <location>
            <begin position="29"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="258" mass="28522" checksum="83B958D31F4F8271" modified="2018-12-05" version="1">MIKKWRSSALVLLAAAIVAFQPVYSAKAATKTEIVISAAASLKDSLEVIAADYEKLHPDVELLFNYGASGTLQKQIEQGAPADLFLSAGQKQVDALKDKKLVDKSTTLLKNELVLVVPADSKLKFNTVKLLTDKKVKKIAIGQPESVPAGQYAKETLQTREVWDTLSDKYVFAKDVRQVLTYVETGNVEAGFVYKTDALTSSKVRIALRIWDSAHTPILYPAAVLSEAEHPKEANEFYDYLQKQAAQKVFVKYGFTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIB2</accession>
    <name>A0A398CIB2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00578">
        <property type="protein sequence ID" value="RIE00578"/>
        <property type="gene ID" value="D3H35_27990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="151" mass="17302" checksum="581650E3A2823AA0" modified="2018-12-05" version="1">MKHGSTNPPKLYRIGELSRLAGISPRTIDYYTGLGLLAPAKRSTGNYRLYDDETLDRIRRIEQMKAQKLSLEEIRDKFAAFNRISHDEHVSRKLAELQSQLTQLERGVKELEPVLDQMKPQQVKRLFRAITPQTAACIEALLLLLGKNNLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIK3</accession>
    <name>A0A398CIK3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation histidine kinase inhibitor Sda</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02210">
        <property type="protein sequence ID" value="RIE02210"/>
        <property type="gene ID" value="D3H35_15845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015064">
        <property type="entry name" value="Sda"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036916">
        <property type="entry name" value="Sda_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08970">
        <property type="entry name" value="Sda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100985">
        <property type="entry name" value="SSF100985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="57" mass="6788" checksum="9CD65027F4003782" modified="2018-12-05" version="1">MILRDIREAIHSLDDTFLINKFISAAEYSMDDEFIQILLQEIKIRNLTLEQVLKELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIT4</accession>
    <name>A0A398CIT4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose-1-phosphate adenylyltransferase subunit GlgD</fullName>
            <ecNumber evidence="3">2.7.7.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glgD</name>
        <name evidence="3" type="ORF">D3H35_26670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00778">
        <property type="protein sequence ID" value="RIE00778"/>
        <property type="gene ID" value="D3H35_26670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011832">
        <property type="entry name" value="GlgDAde_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523:SF6">
        <property type="entry name" value="PTHR43523:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02092">
        <property type="entry name" value="glgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="370" mass="41472" checksum="4F40026B76157341" modified="2018-12-05" version="1">MTLPIMGVINLIHEADEMGSLTANRCLATVPFGGRYRLIDFVLSSMVNSGIPKVAVFAHTKFRSLMDHLGSGSNWDLHRKGSGLFVLPPSMEDQTDFGKGDLYHFYRNRDYFARSPLEYVVISRSHMVCNIDFGPVLLQHRLTGADITVVCKDGLGGTPGLARKARVDETGRIVEMQDHFGRLNSDIVSMEMYLLSKDLLLDLVETSLAQGRDHFVRHAILSRLNELKIHAYMHEGVLGVVNNIAAYYRHTMDLLKPDIWNELFFRPGPIFTKVKDEPPTRYRSGSDVTHSLIANGCEIEGTVHNSILFRGVKVHKGAVVRNSIVMQNGVIGENGSLENCILDKEVEIRPLQQLRGAEDMPFMAVKRKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIV0</accession>
    <name>A0A398CIV0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="3 12">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">mutY</name>
        <name evidence="14" type="ORF">D3H35_16385</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Adenine glycosylase active on G-A mispairs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="3 12"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02300">
        <property type="protein sequence ID" value="RIE02300"/>
        <property type="gene ID" value="D3H35_16385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03431">
        <property type="entry name" value="DNA_Glycosylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005760">
        <property type="entry name" value="A/G_AdeGlyc_MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14815">
        <property type="entry name" value="NUDIX_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01084">
        <property type="entry name" value="mutY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="13">
        <location>
            <begin position="42"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE02300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="370" mass="41716" checksum="6F8A60B5D6EBA2E7" modified="2018-12-05" version="1">MSEKDKELFFSSELLGWYRKVRRDLPWRRSRNPYHIWVSEIMLQQTRVDTVIPYFARFVERFPTLIDLADAPEEDVLKHWEGLGYYSRARNLQAAVREVAASYGGEVPADKESVSGLKGVGPYTAGAILSIAFNQPEPAVDGNVMRVLSRFFCLEEDIAKPATRVRMEALAKRLIPEGAASDFNQALMELGALVCTPKSPGCLTCPVMEHCEGRMAGRENELPIKTKAKPPKKVYRLAVFIEGTREHAGRVLVRRRPATGLLARLWELPHVEAPNESVWASSESAGVWLAGSLAAEGLLVKPKDVVADAEHVFSHLHWYLKVWTAVAEDASLLPGEADDYRWVGPEDFDLLAWPNVFRKLVSDYFNRDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ43</accession>
    <name>A0A398CJ43_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">50S ribosomal protein L7ae</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03326">
        <property type="protein sequence ID" value="RIE03326"/>
        <property type="gene ID" value="D3H35_11600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="L30/L30e/YlxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000231">
        <property type="entry name" value="Ribosomal_L30e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="PTHR11449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449:SF1">
        <property type="entry name" value="PTHR11449:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="1">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="110" mass="11574" checksum="3AB1A2E2AAE01168" modified="2018-12-05" version="1">MTTGNKVLSRLGLAMRAGKLVTGEETVLKAVRAGEAKLVLLAADASGNTGKKLADKCKSFGVPLLIGFTRFELGAAVGKPERVMFAVTEQGFADLIANGWGQHSEVENIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJR7</accession>
    <name>A0A398CJR7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF47 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0111 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02382">
        <property type="protein sequence ID" value="RIE02382"/>
        <property type="gene ID" value="D3H35_16850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="204" mass="23803" checksum="20E15B625D85595B" modified="2018-12-05" version="1">MFRKKDIFFKTLEEMADVIVETSDRFAASVNGDLSDVSAFAKEMKEFEHRGDRLTHTIILELNKTFITPIEREDIMELIKKLDDVLDGVEACSSRFDMYEITKPDIYIRKFGDCLRRSAQEIKKAIYLLTQKKLLAMQEPCVKINELENEGDELMRQGVKNLFQNVKDPIELIKYKELYERLEQTTDSCEDVANTLQSIIMRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJZ8</accession>
    <name>A0A398CJZ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Copper resistance protein CopC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_10060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03636">
        <property type="protein sequence ID" value="RIE03636"/>
        <property type="gene ID" value="D3H35_10060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007348">
        <property type="entry name" value="CopC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04234">
        <property type="entry name" value="CopC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="CopC" evidence="4">
        <location>
            <begin position="38"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="552" mass="60542" checksum="96CBB41660A399ED" modified="2018-12-05" version="1">MIQPWNGQWRTHRFAWLILGLIAIGAILFAGASTAGAHASLTKTEPSADARMDASPEAVRIVFNERLDTGGAKLFVLDELSKQVAGGRDPERIEQGKGLQIPLPKLGEGHYTVSYSVISEDGHPISGAYVFTVGNPAPLPDASQLDPHKQVGHSSHDHGGTALTDRLFLLYAARIVYYAALLVFAGLLLWSVQRSPSETLKQARDKAIDIAGKFMLLAALAYVFISMMDLMRGEPVSAWLDILTDTTTGRLYAATLLLGFAAPLVGGIGLAARLFWTAVMLFVEAWSGHASVFKPVIYTVGLDYVHLVAASLWSGGLILLYVVWRKERPEAGRFALVFSRWALLSFLVLWVTGILSTLDFLPSLAYLFYTAWGKWLIAKAAISLLVAIAAFLIRRRLARGDLPPNGLLKADVGLLAAIVLTIGILTYQTPLPANEPLHYHEMGADLHVTLRVTPNAPGDNSYILKVWLPETLGNPKQVQLRLLPAGREDVGFIDVPIKAFEDDEMDSFPEYAKFAFEAEGPYMPFAGEWKAQIRVTDSKGTELVRETTFRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK26</accession>
    <name>A0A398CK26_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine kinase</fullName>
            <ecNumber evidence="1">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_29830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00237">
        <property type="protein sequence ID" value="RIE00237"/>
        <property type="gene ID" value="D3H35_29830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="180"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="378" mass="42772" checksum="7803BFE190965B04" modified="2018-12-05" version="1">MLFMLRSLLVLGPALGAMLLQSYESYSLFTFFILLHLLIVEAHRKLASNEWALAILLAESAYAAWMSHHYGSILFMTFFAALFAYLPYSSFVNWKPLLLLQLILMNISLAGSPPVYWVIANLLFVALSALLLKLRSTSKSMLDVEEQSDLLLLKHRELGEARKQLIEYARNVEDSAQKEERNRISRDIHDDLGHKLIRLKLMMDAAVQVLPNQPDKGMEIVQSVRDQLSDSMELLRSTVRKLKPDERTMQAYSLTQLIKELGTGAGQGITVRHRIEGMPYALYPSLEFILYRNAQEAVTNAIRHGSASEALITLEYEPKQVVMNVTNNGKPPEGDWVRGLGLRGMEERVSLVGGRLEVVVEPIFTVRTVLPTYRNEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK45</accession>
    <name>A0A398CK45_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_22865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01238">
        <property type="protein sequence ID" value="RIE01238"/>
        <property type="gene ID" value="D3H35_22865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017182559" evidence="2">
        <location>
            <begin position="23"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="505" mass="56821" checksum="EEB541B946B85BD7" modified="2018-12-05" version="1">MRKMLILLITAISLTGCFGGSGEEVQTAEPTATSIDQSADSNVEDPEPSATNFDILKQIMGLNKQQVIEKLGKSYTKYVGSDSQPGQGIAYEQLGLRIVFDEKMGRIETIYCNELIDIEGVKLGMEPSYFIDMLGGGAEKMTTGRKPSYEVSFNFGPFFVWIQAANKESPTTQLVIRRNHNYDESIASHAAFKSDLKHIQAIFNMDREPVIETLGMDYSLYYGNDGDTHLGIGINFEKYGLTLLFDDSGDRVDGIYCDEGAAYEGVTKVDINGAKLGMTFAEIRKLLGEGEFIDRTTFSEGYPPVYSLNYDFGNVTASFGVSDREGRTDELHIYRISENNRSNPKVNLIKPIANELDFSKIKELLSLTAEQVVEKLGDKRREYNKHWGQFELGNGLFYEQYGLIFAIDSDSQYTIYSRENVEINGARLGMTFSEIQQYLGTEGVVDWVEAYQPYYRLTYTYDDFTISFASYDEDGKTVEVKIQPREPEEREANSKKTEAGLRSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKD3</accession>
    <name>A0A398CKD3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA alkylation repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01659">
        <property type="protein sequence ID" value="RIE01659"/>
        <property type="gene ID" value="D3H35_22260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="231" mass="27255" checksum="726A345F6FC7413A" modified="2018-12-05" version="1">MEETIKALQMEFERHRDPSAAEAMEGYMRGQFPFFGIKAPLRRELMKAFLAEHSPSKELIWLLWNLPEREYAALAVDLLFKIRKQLEPADIALVERCIVTKSWWDTVDGIASSVVGYLFDRFPELRDEYAERWIRSDNFWLNRTAILFQLRYKEKTDERRLYDYVRRHAGSSEFFLQKAIGWALREYAKTSPASVVRFVGAHEWKPLSRREALKNIDESALAEQAEQETSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKN8</accession>
    <name>A0A398CKN8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TrkA family potassium uptake protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_18765</name>
        <name evidence="4" type="ORF">D3H35_18860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02699">
        <property type="protein sequence ID" value="RIE02699"/>
        <property type="gene ID" value="D3H35_18765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02712">
        <property type="protein sequence ID" value="RIE02712"/>
        <property type="gene ID" value="D3H35_18860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="137"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="221" mass="24158" checksum="ECB48FAFD8D488C5" modified="2018-12-05" version="1">MLKKQYAVIGLGRFGSSVAAYLTGMGYEVLAVDDNEERVQDIVHQVTHAVSADSTDEEAMKALGIRNFDVVVVAIGQDIQASIMTTLIVKELGVPHIVVKAQNDMHGKVLSKIGADKVVFPERDMGLRVAHHLISPNILEHIELSGDFSIVEMKAPPAFVNKNLKQLDFRAKFGCNVLAVKRGEDMDIAPRADAPLLQGDVLVIVGKNERLMKLEQTYAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKQ4</accession>
    <name>A0A398CKQ4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_28805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00467">
        <property type="protein sequence ID" value="RIE00467"/>
        <property type="gene ID" value="D3H35_28805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="317"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="408" mass="44089" checksum="23EEA30FF4C0CEDD" modified="2018-12-05" version="1">MVIIGAGESGARAAVELRAKGWAGSITLIGNEDQLPYERPPLSKHQLYQDEEPIPTAIVTRQQISDNRIQLISDDPAIKIDPVNHVVELKSGLSVPYERLLLAIGARSRQLNVPGAGAQEILYLRNFADALRLRGRLQPRKHIAIIGGGFIGLEVAASAIAKGCRVTLIEVAPRILMRGVPKEIADEVEQLHRHNGVEFIVGKMIDSVDKTESGYRVVLADGSDVACDVVLAGVGAIPETTLAEDCGLEIENGIKVNEYLVTSDPDIWAAGDCCSFPHPLYGGRRIRLESWRNAQNQGAHAAASMLGSLEPYASVPWFWSDQYDQTLQVAGLTDGTEQIVFRDMGDAGKLYFHLAQDGRLVSVSGIGPEGGLSKNFRFAEMLAEKQAKPDPASLADNAVSLKGLLKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKR1</accession>
    <name>A0A398CKR1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">M3 family oligoendopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_19045</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02742">
        <property type="protein sequence ID" value="RIE02742"/>
        <property type="gene ID" value="D3H35_19045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09607">
        <property type="entry name" value="M3B_PepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034006">
        <property type="entry name" value="M3B_PepF_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013647">
        <property type="entry name" value="OligopepF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042088">
        <property type="entry name" value="OligoPept_F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011977">
        <property type="entry name" value="Pept_M3B_clade3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08439">
        <property type="entry name" value="Peptidase_M3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02290">
        <property type="entry name" value="M3_fam_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3_N" evidence="8">
        <location>
            <begin position="114"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="337"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="594" mass="66993" checksum="3F2AEE39C0D17653" modified="2018-12-05" version="1">MSKSYSMTWDLESLFPGGSSSPELANFMEETERLTGALLERLRSAGDEQPSHTELTEWTSALQDILSRLREGESFIGCLTAQQTSDRRAVAWTEKIQTLSAKFRQAQDLYDAKIANVPDDRWEAWCSDPDRSAISFVLNERRDFAKEKLSPELEGLASELAVDGYHGWGEHYNTIVGRIAIPWEENGTAVTLSAGQAANKLDHPKSEVRDSMAAKWEEAWAEQSDLCSDTLNRLAGFRLKLYGLRGWEDPLREPLRINRMSRETLDAMWEATEGAIAPLTKYLQLKARRFGKDKVAWHDVDAPLSSVGETIAYDDAAELIIDAFEHFSPGMAALARRAFDDRWIEAEDRPGKRPGGFCTGLPRSRQTRIFMTYSGTPGNVSTLAHELGHAYHGYLVDGLQPMAQEYAMNVAETASTFAEVLVSDALLKRAASDEEKLSLLDDRLQRAVAFCMNIRARFLFETRFYDRRKAGMLEADELGKMMVEAQKEAFGDSLSSWHPNFWAAKLHFYLTDVPFYNFPYTFGYLFSTGLVAVAEKEGESFRDRYDALLRDTGVMTVEQLASHHLGVRLDEPDFWRAAVERVIADVDAFSELAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKV2</accession>
    <name>A0A398CKV2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NEAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_20185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
            <topology evidence="1">Peptidoglycan-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02930">
        <property type="protein sequence ID" value="RIE02930"/>
        <property type="gene ID" value="D3H35_20185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06920">
        <property type="entry name" value="NEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006635">
        <property type="entry name" value="NEAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037250">
        <property type="entry name" value="NEAT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05031">
        <property type="entry name" value="NEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00725">
        <property type="entry name" value="NEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158911">
        <property type="entry name" value="SSF158911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50978">
        <property type="entry name" value="NEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017344686" description="NEAT domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="NEAT" evidence="3">
        <location>
            <begin position="36"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="196" mass="21474" checksum="92751A040713D3EE" modified="2018-12-05" version="1">MKLLKKTFMFVLIAALLLSAQHLAPVSASIEPGTVIPDGEYSLSYQYVKDGTTQVSAANDFMVPDTGKLIISEGKAYFEHEVSKADYATFAYLGSRKAGAAKAVITTVGDAETANGQDGYEPVVVRDAANSSNVVVRLTIVDVWKKQDVLMHIDDKENIYNLPVRYNHWYNAQLEIYTTNITLPPLRAAAMEAPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL38</accession>
    <name>A0A398CL38_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotidyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_11890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03373">
        <property type="protein sequence ID" value="RIE03373"/>
        <property type="gene ID" value="D3H35_11890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009267">
        <property type="entry name" value="NTP_transf_6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39166">
        <property type="entry name" value="PTHR39166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06042">
        <property type="entry name" value="NTP_transf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="193" mass="22938" checksum="0913D243C1447774" modified="2018-12-05" version="1">MTHFSSDHLEQYLIRIIEQNKLVYDFLNQVQKLKINHYYIGAGCITQTVWNHLCGMPLSYGIKDIDFVYFDDDLSEQREEETKSEVERLFSELPFKIDVKNQARVHLWYKDRFGYEIKPYRSLEDAINTWPTTATALGARISGSDWDVYAPFGLEDLFGMIVRPNKAQITKEIYEDKVRRWKGQWDKLIIVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL53</accession>
    <name>A0A398CL53_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-ketoacyl-ACP synthase III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_20195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02932">
        <property type="protein sequence ID" value="RIE02932"/>
        <property type="gene ID" value="D3H35_20195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="3">
        <location>
            <begin position="111"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="2">
        <location>
            <begin position="246"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="333" mass="35590" checksum="38C89CD741CC12F9" modified="2018-12-05" version="1">MKTRRVKILGTGKYMPSRMVTDEEMDLRLGTPRGWVRKMTDVAVRHFASDEETASYMGARAAKAALAEAGLSLADIDCLVCTSGTREQALPSTASLIQQALGEELYGVPAFDIDATCISFLVGLDIMSYLIEAGRYRHVLLVSTEIASVGLNWNDKKSAALFGDGAAAVVIGPSAGEDKSGIVGASIRTYSNGARLSEIRGGGTRIHPREHNAETEADFLFRMNGEAIFKMASKLLPGFVDELLAPSGSRMADFQAVIPHQGSAMAMRLMRKKLGISAEQLVYITPNHGNTIAASIPMGLHEAVSQGKVRRGDRVLLIGTAAGLSLGGMILDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL70</accession>
    <name>A0A398CL70_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HD-GYP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_16445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03155">
        <property type="protein sequence ID" value="RIE03155"/>
        <property type="gene ID" value="D3H35_16445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="11"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="183" mass="20940" checksum="FF8D492ACD7282B3" modified="2018-12-05" version="1">MELLRDRHEETYRHCVRVSLLGEKLARSLRMSEQDIEALVRGCLLHDVGKLLVSLAILDASGPLDERQWDEMKRHPRIGADILESMGLRGEIIDLVLHHHERWDGQGYPSGLHKEEIPYGARICAVVDAFDSMMSDRPYRQGKTVSEALEELRKHAGTQFDEAIVESFSRLAEELGRMYDIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLF7</accession>
    <name>A0A398CLF7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_27340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00677">
        <property type="protein sequence ID" value="RIE00677"/>
        <property type="gene ID" value="D3H35_27340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="85" mass="9341" checksum="E62AB15B88ED58C3" modified="2018-12-05" version="1">MRLAVREEQPSVIRIAVEDNGCGMSRTKAEQLLKPEANHKGVGLFNINQRIKLIYGGSLRIDSEESMGTKVTFDIPVEPTKITGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLF9</accession>
    <name>A0A398CLF9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_21220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03100">
        <property type="protein sequence ID" value="RIE03100"/>
        <property type="gene ID" value="D3H35_21220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="67" mass="8063" checksum="A9EC1A2080C63D67" modified="2018-12-05" version="1">MREMNLLEALSPRNSRERSQVIQTSASRKVRPEDEMIILMRSARRRFKKYVAEGKIEIVSEREWTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLM9</accession>
    <name>A0A398CLM9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADAR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_16935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O = 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23436"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:137796"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O = 5,6-diaminouracil + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:55020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:46252"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03160">
        <property type="protein sequence ID" value="RIE03160"/>
        <property type="gene ID" value="D3H35_16935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="SSF143990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="3">
        <location>
            <begin position="13"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="231" mass="27453" checksum="A7F37E7BA5A915C1" modified="2018-12-05" version="1">MKELKPEERFIRFYETDKPYGCFSNFAKYPIFLNNKDWATTEHYFQAQKFVGTEYEEEVRLASTPMEAARLGRDRNKPLRKDWEEYKVQVMREALIAKVEQHPSIKSILLSTGDCTIVEHTTNDAYWGDGGNGQGQNMLGKLLMEIRNSLEEYVPEFFLPQWIVFPDIHPFSIGWRMGAGEGYLMYLWEWRKKQSPEALKEYDEYFTPPEEWAEARKIREAHKNKNEEEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLQ6</accession>
    <name>A0A398CLQ6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-layer homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03190">
        <property type="protein sequence ID" value="RIE03190"/>
        <property type="gene ID" value="D3H35_18830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="78" mass="8428" checksum="98C91EB460154C80" modified="2018-12-05" version="1">MGSHWASGSSISWLRNGLLSGKTESAFAPDEAYTRAEFASLLVKGLGLQDEQGASAFRDVKEPSWYAKTYLSPQGRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLQ7</accession>
    <name>A0A398CLQ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3'-5' exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00581">
        <property type="protein sequence ID" value="RIE00581"/>
        <property type="gene ID" value="D3H35_28005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="62"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="247" mass="27925" checksum="67A191DC6F223E80" modified="2018-12-05" version="1">MNEPKGTNSMGRMWHLYKMGGLTPAIASMLGSSNAQQMAFIRSMSRDQRKENTLDIPLAELEAVVFDLETTGFYPYNGDEIISIGGVIVRGGEFAEAEPFYRLVNPKRKVPRHITELTGITNDMVENAPDIMHGLHDFMDFVGKRVLIAHGSGHDKQFLNSALWRTSKVNLTHRVLDTMMIAKWLNPASGQYGLDELLETYGIEITERHHALHDSIMTANLYFSFLKQIHARNLTTLGDLYAYLSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLT3</accession>
    <name>A0A398CLT3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03202">
        <property type="protein sequence ID" value="RIE03202"/>
        <property type="gene ID" value="D3H35_19280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025917">
        <property type="entry name" value="YuiB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14068">
        <property type="entry name" value="YuiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="91" mass="10171" checksum="608E1CB97A871B69" modified="2018-12-05" version="1">MLQEIVGALLFFVFAFGIGFILNMLVKTTWFPLWAFVIVVLPLGAWHFWDPDTTAGSFIAVFLPPMLAIVGGAYVSGWAIRKLRLGGYKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMC8</accession>
    <name>A0A398CMC8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000026">
        <property type="protein sequence ID" value="RIE04506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04506">
        <property type="protein sequence ID" value="RIE04506"/>
        <property type="gene ID" value="D3H35_05740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="121" mass="13343" checksum="4BAB745DA72832B0" modified="2018-12-05" version="1">MNEMDTSSQRSIDHNRTTFLRVSEAARTTIRIGFPPVLRATVGTTADRNHNHTVIARTANITAQSNCNMNKNGISRLESTEVYGFTFHTTNIPATRAPADASQHKPNRLTPSTLRVQTAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMC9</accession>
    <name>A0A398CMC9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000035">
        <property type="protein sequence ID" value="RIE03605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03605">
        <property type="protein sequence ID" value="RIE03605"/>
        <property type="gene ID" value="D3H35_10725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="80" mass="9299" checksum="C921F17D754056D5" modified="2018-12-05" version="1">MYRYKVLFRHVDGTERPLSLQSPDIIERGDVVEILPRELYSIVPVPIQALNFPWERYSHVEFGRNTRIPSIGSAKRTALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CME5</accession>
    <name>A0A398CME5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03420">
        <property type="protein sequence ID" value="RIE03420"/>
        <property type="gene ID" value="D3H35_12195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="134" mass="14767" checksum="69FA1E158ED4A995" modified="2018-12-05" version="1">MKPQYDGGIAFRKGLLPLRSRGKSDLSTKRASWLSKRKITEWTASMKEWRLSSLLRIPSSVIWTKPAYEGMSDFSEGMSAVSNGGKFGYVVNPLKNKSLLMGEEPPISDFLEAGGSFLFGNETNGFPGILSVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMM8</accession>
    <name>A0A398CMM8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extradiol dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01157">
        <property type="protein sequence ID" value="RIE01157"/>
        <property type="gene ID" value="D3H35_22385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="134" mass="14711" checksum="F06461CFE38A3B58" modified="2018-12-05" version="1">MAINDIWINLPVKDLDKSAEFFNRIGISAFNGGDMVRLLVGDKQTVVMLFPESTFQRFTGNEISSTSQGTEVLLSIGAESKEDVDDLIGKVTEAGGTVYGKPSDQGWMYGAGFVDLDGHRWNVLYMDLSQAPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNJ8</accession>
    <name>A0A398CNJ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_28250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000055">
        <property type="protein sequence ID" value="RIE00484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00484">
        <property type="protein sequence ID" value="RIE00484"/>
        <property type="gene ID" value="D3H35_28250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="22"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="124"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="178" mass="19601" checksum="5BD245FBBBEBC506" modified="2018-12-05" version="1">MVLQSRQYVQQYGKTSSHAKHDSGSLTIGRPVANTQIFILDSIDNLQPIGVPGELCISGAGLARGYLNQPELTAEKFVANPFAPGERMYRTGDLARWLPDGNIEYLGRIDEQVKIRGHRIELGEVESALRSHESVKEATVIARKDEEGSAYLCAYFVANGNLGAAELRKRLSEMLPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNX2</accession>
    <name>A0A398CNX2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_02795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05076">
        <property type="protein sequence ID" value="RIE05076"/>
        <property type="gene ID" value="D3H35_02795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="286" mass="31048" checksum="487D906EA63F0825" modified="2018-12-05" version="1">MKHPSYSSLGQPCRNFNILASAVVTDPLDNREKLVLSNYAMGATGSLILIDPLTGEGESLELPVGAGAWGLANLGDEKLVVGTCVGQAYLHVLDLRTRRWAQALAAEGEFYFWQLTVGSDGNVYGGTYPGCSLIKYDPDSHTLTNLGKVSGNAANQYSRPVWGEAPGYILANYGFDTTGMTAYDLKDGTFRSFGEPGEQIRWATDRLVCAEKDGALSYYNAATLLPFAGDLAKELTPRTSVALSNGQRIPVRRLVGNRLAGVRARTTSSFRNRTDRLIRTSRSRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP02</accession>
    <name>A0A398CP02_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_06685</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CpsD/CapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04293">
        <property type="protein sequence ID" value="RIE04293"/>
        <property type="gene ID" value="D3H35_06685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="AAA_31" evidence="10">
        <location>
            <begin position="44"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE04293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="231" mass="25599" checksum="F30241ECCB600CF9" modified="2018-12-05" version="1">MSNFTPKSNKRPIVVHSNPKSPASEAYRNLRTNIQFSAIDEQVRTIMVTSAGPGEGKSTTSCNLAATYAQTEQKVLLIDADLRKPTVHHTFGCSNRFGLTHVLTNQCQYKEVILESYVPNLSILPAGAIPPNPSELLASNRMRAFIDEIKKEFDIIIIDSPPVIAVTDAQIVATRCDGVVLVVDYGNVKIAQAQKAKEKLEHVNARILGVVMNNVKRSVKDEYYYYYGENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP47</accession>
    <name>A0A398CP47_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="2">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">carA</name>
        <name evidence="4" type="ORF">D3H35_06645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04285">
        <property type="protein sequence ID" value="RIE04285"/>
        <property type="gene ID" value="D3H35_06645"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="3">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="381" mass="42570" checksum="5D66307A14F66C23" modified="2018-12-05" version="1">MQARLLLEDGTLFTGLGFGAEGASVGEVVFNTGITGYQEVLSDPSYCGQIVTMTHPLIGNYGINRDDFEAIRPYIHGFVVRRHESVPSNWRAQYTLDHLLKEYGIVGISEIDTRMLTRIIRQHGVMKGILTTGTERIEELKERLGVTPLLRDQVARTSTPNVFSSPGERERIVLIDYGAKSGILRELTKRGCDVVVVPHDTTAEEIRRLSPDGIQLSNGPGDPKDVPHAVETLRQLIGEYPIFGICLGHQLFALACGADTGKLKFGHRGGNHPVKELESGRCYITSQNHGYTVEESSIEGTELEVTHINNNDKTIEGLKHKRFPAFTVQYHPEAAPGPFDNSYLFDRFLDMIREHKRLNPEKPRQAQLAQTLRGELQYAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP67</accession>
    <name>A0A398CP67_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04373">
        <property type="protein sequence ID" value="RIE04373"/>
        <property type="gene ID" value="D3H35_07220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="187"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="391" mass="42640" checksum="31161417E0DEDF9D" modified="2018-12-05" version="1">MALHENTIASLYGDMVKWRRHLHKNPELSFMEHETSRMIADLLESWGLEVKRGVAGTGVTALLRGGLPGRSIALRADIDALPIQDEKECEYSSTVPGVMHACGHDAHTSELLAVAKYYSMHREETEGSRLFLFQPGEEVLPGGAVAMIEAGALDEADAVYGIHLWSPTPYGMAVTRSGPFMAAPDEFEIEIVGRGGHAGLPHQCADALLAGAALVTALQTIVSRSVNPLDAAVVSVGRLSAGTANNIIAERCRLSGTIRSFTEEVRAQVRSRLEAIVKHTCELHGTQYTLQFIEGYPPVVNDDKETERFFRVAVPLLGEANAVRCERIMAGEDFSYYLRRKPGCFFFVGAGFEDGSSAPHHHPRFDVDERAMLIAARLLIAVADDSARSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP77</accession>
    <name>A0A398CP77_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_06910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04325">
        <property type="protein sequence ID" value="RIE04325"/>
        <property type="gene ID" value="D3H35_06910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="88" mass="10404" checksum="8E78132CD0ACBA02" modified="2018-12-05" version="1">MDEYVWAIFVAENDGVFPNFYPIGLYISREKAMEELEALPRDMNYQLLRLPVNRMFPYYHKKNGKLVGMDGIHHEHIHFRDNYNGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPW8</accession>
    <name>A0A398CPW8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe/B12 periplasmic-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04575">
        <property type="protein sequence ID" value="RIE04575"/>
        <property type="gene ID" value="D3H35_05675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="4"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="279" mass="31690" checksum="82738BC0C3C3B437" modified="2018-12-05" version="1">MFHRHVGVPPTFYRKVKKLRVAVAASLPYRDSLLSFGVEPVASVNLFRYPGMAVKEYELVFASQWEELERAKPDLIIGDFYHFSFRDRFQGIAPVSSLLADRSWVNNYRKMAEILGSSEEAEQAVNRLAMRVAAARSLLAARMGGKSIVVLQVTNHNIRIQGATDHPLSELLFGELGLQPGRTEQSNAKRLELQPEWLPQIDTDYALVFQNHIRAGSETIYDRMCGTHAWRSMRAVQNGNVLLIPNWFKMSWSPIGREEIIDELLMMTDTLPEAAKESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ13</accession>
    <name>A0A398CQ13_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA sulfur modification protein DndD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dndD</name>
        <name evidence="3" type="ORF">D3H35_24575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01531">
        <property type="protein sequence ID" value="RIE01531"/>
        <property type="gene ID" value="D3H35_24575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017599">
        <property type="entry name" value="DNA_S_DndD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03185">
        <property type="entry name" value="DNA_S_dndD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="2">
        <location>
            <begin position="16"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="385"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="651" mass="73985" checksum="D723B00B92C373DB" modified="2018-12-05" version="1">MSGQHHLSPTPNSVEGKPITLIGGMNGGGKTTILDAILLLLYGQRCPSYKESGISYSNYLEACMHRSRDFSSNQSWIELKIKAFLDNKESSLLIRRSWEKGNVRIKESLQVWKEDVLDSYLALNWDTYVEDLLPYGIANLIFFDGEKIAKLASENDNSETTRKSIQSLLGLDIVDRLIVDMKKVINKHEKLIPSIEEDLDLNNLKTAIQERQLQLQSINQEITSTKTSLLKLNHKLEQKEDQFLKTGGELAQTRSTLISTKAKLESSLAENKEKMISLAASNLPVSMLTPLLNSLLDNMKTEKLRKDSASILPILKQHDASIVSALKEFNATDELQNNLVSYLDNLRKTYEANTTIKSQFPSSEKNIELVVRFLGGESQQLCFTAKTLVNNTESLELQLEQADRHLLLEVDESKSNLILKELKSLSQKIGEVKESLVRLEQNYQQKEIEINRMTMQYRKNLETILEVSNDAEESKRIIEYSIRTQKKMEEYKKVLKLKKLSDLSLHITEAFLFLIHKTSLVSKVIVDNDALEVKLFDMEGIELPKSRLSAGEKQMLAISILWGLAKSSGRQLPVIIDTPMGRLDSSHRLNFVEKYLPNASHQVIILSTDTEIQGQYLSSIKKHINNSYMLMFDHNEQTTKITKGYFDGEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ15</accession>
    <name>A0A398CQ15_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pirin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_05820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000026">
        <property type="protein sequence ID" value="RIE04522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04522">
        <property type="protein sequence ID" value="RIE04522"/>
        <property type="gene ID" value="D3H35_05820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="PTHR43212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="69" mass="8117" checksum="E1387666DCB2BF98" modified="2018-12-05" version="1">MINVQRSQDRYSADHGWLKSRFSFSFADYYDPDNMSFGPMRVLNDDWIAESEGFGMHPHREMEIVIVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQB4</accession>
    <name>A0A398CQB4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Chorismate synthase</fullName>
            <shortName evidence="11">CS</shortName>
            <ecNumber evidence="4 11">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">aroC</name>
        <name evidence="12" type="ORF">D3H35_03950</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="11">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 11"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04652">
        <property type="protein sequence ID" value="RIE04652"/>
        <property type="gene ID" value="D3H35_03950"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0274">FAD</keyword>
    <keyword evidence="11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11" id="KW-0288">FMN</keyword>
    <keyword evidence="10 11 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="132"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="252"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="312"/>
            <end position="316"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE04652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="389" mass="42398" checksum="8643DCEDDA1C4FD0" modified="2018-12-05" version="1">MSLRYLTAGETHGPQLTAIIEGLPSNLELDFEEINFQLQRRQKGHGRGRRMQIETDTATIVGGVRHGRTTGAPVALFVENKDWKHWTTVMNIEPVEGSDETKRRVHRPRPGHADLNGGLKYNLKDLRNVLERSSARETAARVAVGAIARQLLARFGIKVAGHVVSICGVEAAAPNLPIDELIRVTEESPVRVADKAAEQKMIELIDKTKEDGDSIGGIVECIVEGLPVGLGSHVQWDRKLEGRIAQAVVSINAFKGVEFGLGFEAGRRPGSQVHDPILYNEQQGFHRASNNAGGFEGGMTTGEPLVVRGVMKPIPTLYKPLPSVDIDTKEPFTAQVERSDACAVPAASVVLEHAVAWEVAKAFLEKFGGDSIEEIQANLDNYLKQVAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQC9</accession>
    <name>A0A398CQC9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04672">
        <property type="protein sequence ID" value="RIE04672"/>
        <property type="gene ID" value="D3H35_04065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014231">
        <property type="entry name" value="Spore_YpjB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09577">
        <property type="entry name" value="Spore_YpjB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="316" mass="34376" checksum="D320315C53B6DCD3" modified="2018-12-05" version="1">MSVLLDKRQYSSVKWREGRIVLLALLGLLLGNPVVAWGDAQGSIDADPTATSGISSASGDSAVRSFRDAAELLYKSVQDGDKLESLRRMQQTERGFLALRLEGLTSVEGVQALSNSIAGLKRQIVSVSPDHQRWKTAAAEVRLAADALANPGEPMWHRYRAVVLDDLNSLDKALKSEGASSLRARSAFQALNNHYRLIRTAVLLSTEPFVAERADSAMAYASRVMSAAKADAKLTDNLIPALTNALEGVFPNKDEEPTVSVPASGPTWGWSAMIGSIVVAMLTWVGWRRYRSDMSTGVPALPKRGSRRDPADRWMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQM5</accession>
    <name>A0A398CQM5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_11060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03569">
        <property type="protein sequence ID" value="RIE03569"/>
        <property type="gene ID" value="D3H35_11060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="36"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="74"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="286" mass="31128" checksum="7707EC87D95C4272" modified="2018-12-05" version="1">MALNFARSGSAELEWGRGPEEAYPSEADVPWGERLISVDNLTLAYSNGRGKPGKTVLDGLSLDIREGEFVVVLGASGCGKTSLLRLLAGYERPTSGAVEVLGRPSSGPSAEVGVVFQHANLFPWLTIQRNVEFGLKMKRVGRAERKRLASGYLSQVGLSAAADYLPYQLSGGMKQRGAIARSLASEPRILLMDEPFGALDAITRENLQTLVKSIWRTTGLTVFFITHDVDEALYLGSRIVVLNGSPGQIGTDIANPLFEREDSVTRLRSHKDYAAARDHLLKRLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQW8</accession>
    <name>A0A398CQW8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_03425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000020">
        <property type="protein sequence ID" value="RIE04933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04933">
        <property type="protein sequence ID" value="RIE04933"/>
        <property type="gene ID" value="D3H35_03425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="2">
        <location>
            <begin position="119"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="632" mass="69026" checksum="1C4C0356E4846FF4" modified="2018-12-05" version="1" fragment="single">MKTMGKKAAIRYARNERGPTLGYSEASGVRLLYEDGLAFKDLNKDGKLDRYEDWRLSPEERAKDLASKMTIEQIAGLMLYSSHQAIPGNLNWFPATYGGQFFEASGAAPGDLSDQQLSFVANDHIRHILITRIQDPATAALWNNNVQAYAESLGFGIPANNSSDPRHSSDTSKEFNAGAGGAISMWPESMGLAAAFDPAVARKFGEVAAKEYRALGLATALSPQVDIATDPRWYRFGMTFGEDPQLAADMARAYIDGFQTSEGEAEIADGWGCDSVNAMVKHWPGGGSGEAGRDAHFGYGKYAVYPGGNFDEHLVPFTEGAFRLAGKTGQASAIMPYYTISVGQDSKNGENVGNSYNEYLINDLLRGRYGYDGVVCTDWGITADEGEDISRLFPGGRCWGVEEGYSVAERHYKLIMAGVDQFGGNNEIGPVIEAYNIGARKHGESFMRLRFEQSAVRLLKNMFRLGLFENPYLEADVTTATVGQAEFMEAGYEAQLRSIVMLKNEGVLPVARKKTVYIPKRSLPADTDWMGMPIPPSESYPIHLDVVKKYFAVTDRPEEADFALVCIESPRSTKGYSKADAEAGGNGYVPISLQYAPYTAEYARETSLAGDARDVLNRSYKGKSVTVSNAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR82</accession>
    <name>A0A398CR82_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Flagellar biosynthetic protein FliQ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">fliQ</name>
        <name evidence="10" type="ORF">D3H35_11450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Role in flagellar biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the FliQ/MopD/SpaQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03298">
        <property type="protein sequence ID" value="RIE03298"/>
        <property type="gene ID" value="D3H35_11450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002191">
        <property type="entry name" value="Bac_export_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006305">
        <property type="entry name" value="FliQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34040">
        <property type="entry name" value="PTHR34040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01313">
        <property type="entry name" value="Bac_export_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004669">
        <property type="entry name" value="FliQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00952">
        <property type="entry name" value="TYPE3IMQPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01402">
        <property type="entry name" value="fliQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="89" mass="9584" checksum="68D1759B4E8B779E" modified="2018-12-05" version="1">MSSEFVIGLAGQALYTILKVSAPMLGFGLIVGLLVSIFQATTHIQEQTLAFIPKIIAVFLAVLLFGPWILNVMVDFTSQLLGNLANYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRB9</accession>
    <name>A0A398CRB9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_09660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03809">
        <property type="protein sequence ID" value="RIE03809"/>
        <property type="gene ID" value="D3H35_09660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005976">
        <property type="term" value="P:polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="MannoseP_isomer" evidence="2">
        <location>
            <begin position="303"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="457" mass="50970" checksum="73C9C7F2EB4ACEEE" modified="2018-12-05" version="1">MKLILLSGGSGKRLWPLSNESRSKQFLKVLKREDGTMESMVQRVWRQLGRAGLAEHAYVATGTQQAEMIKGQLGDVPVVLEPSRRDTFPAIALTAVYLYSIEGVSLNEMVAVLPVDPYVEDRFFPCVAELESVLERSGASLALMGVKPVHPSEKYGYIVPRESETSAGSETASSPRLVERFTEKPTQAEAEALISQGALWNCGVFAFRLGYLIDLLIEKQIPLHFEELSKHYDKLPKISFDYEVVEKASPIAVMEYDGYWKDLGTWNTLTEEMEPGIIGKGVLGENSDNTHVINELGVPIVVMGLPNVVVTASPDGILVADKQTSPRIKEVVGSWDDRPMFEERLWGSYRVLDYNVHEDGIQSMVRRIHIEASKHLSYHFHASRSETWTIVSGEGEMVMDGSWRKLYAGDTVYIPPYAKHSVLAVSDLVIVEVQSGSDLSDEDLFETSVNWKEISAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRE0</accession>
    <name>A0A398CRE0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_02935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05102">
        <property type="protein sequence ID" value="RIE05102"/>
        <property type="gene ID" value="D3H35_02935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="69"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="274" mass="30676" checksum="C975BD82166DDAF5" modified="2018-12-05" version="1">MKLRPKKTPISAAILWGYSLLTLLVLVYMTYQSFRPKKDLLSATFAIPKHLGFGNFRKLFVEAGFFTYLLNSALILFGSLALLVMLSTMVAYGIGKFQFKFKSGLLMYFLIGLMFPVQLGIVPIFLLIRNMGLLDNQLSVVLVLASGLSMPVFLLTTFFAKLPHDLYESAKIDGAGEWTTFIRVMFPLASPVTFSICIIMSMQIWNQFFVPLIFLHSETKKTIPLMIMKFTNNTIYNMDMAMVGSVMATVPLLILFFFFSGRVIDGVATGGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRV0</accession>
    <name>A0A398CRV0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03939">
        <property type="protein sequence ID" value="RIE03939"/>
        <property type="gene ID" value="D3H35_08215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="166" mass="17345" checksum="96332D80F33784DA" modified="2018-12-05" version="1">MDIIMLVLFGIGAGYALLSLVFGDWLGFDFHSGDLPYLSPTVIATFLNVFGGIGYMLLNQTDWSMIAVASVSLISALAVSSVVLFAVVLPLHAAQKGMAKSAKAMIGLAAEVVTAIKAPRLGEIVYEQGGTRHSAPAKSAGEPVISQGTSVRIVGEMAGTFVVETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS36</accession>
    <name>A0A398CS36_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04039">
        <property type="protein sequence ID" value="RIE04039"/>
        <property type="gene ID" value="D3H35_08790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="220" mass="25429" checksum="39A0FC1D51D2E502" modified="2018-12-05" version="1">MLFAKFILASTVEFLSFFIFAMVLFRFSVKEALLKFIIASLIFSFVSNTLQVESLQNISPLVNIFLFVFLITIILRVRLLHSIVMVAITFVAFSLVQWLLLTIFLKAHLFNEILPYTNNGFALQLSTALTLCIISAFIFMTNGGFSYIQSSSRFYKETFKGNRLFFLFLLLALLEIILVNIFYLASVDLPYYIYFVSITIMIILVLLIYFSIRKDGRRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS56</accession>
    <name>A0A398CS56_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1801 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_00940</name>
        <name evidence="2" type="ORF">D3H35_03315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04979">
        <property type="protein sequence ID" value="RIE04979"/>
        <property type="gene ID" value="D3H35_03315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05383">
        <property type="protein sequence ID" value="RIE05383"/>
        <property type="gene ID" value="D3H35_00940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="DUF1801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1801" evidence="1">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="129" mass="14329" checksum="34B0778A9820FE07" modified="2018-12-05" version="1">MEGNKLTYSSIDDYISTFSPEVQEILQTLREVIKKSAPDAKEKISYQMPTFELHGNLVHFAAYKNHIGFYPGAGGVSAFQSELSAYKGAKGSVQFPIGKPLPYELISRIVAFRVADNIERAKGKSNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CST3</accession>
    <name>A0A398CST3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03818">
        <property type="protein sequence ID" value="RIE03818"/>
        <property type="gene ID" value="D3H35_09705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="155" mass="17352" checksum="353CA8D686289901" modified="2018-12-05" version="1">MAGRARTGSGGELENRRGNPPAHLTDRAFENVTVTGFVKELDPYYREASVCVAPLLTGAGVKFKVLQAMAYGLPVVTTPVGAEGIAENEPKPLLEFVTTDPGAFSDGVVRYLQDESLRKRDGFQLRRWMENHYDFEKNTVQKALLFYETFYPDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT14</accession>
    <name>A0A398CT14_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000013">
        <property type="protein sequence ID" value="RIE05300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05300">
        <property type="protein sequence ID" value="RIE05300"/>
        <property type="gene ID" value="D3H35_01360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="88" mass="9932" checksum="C08428BB41C0ECA2" modified="2018-12-05" version="1">MEMGNLAIVNEPSVRKRRETYGVNSFQGYIEETLSRLRIPFQAFESLQAALEWKPDILIPALCEENADNGQKLQDYVEAAALSSPMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT91</accession>
    <name>A0A398CT91_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02531">
        <property type="protein sequence ID" value="RIE02531"/>
        <property type="gene ID" value="D3H35_17730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="78" mass="8583" checksum="27C36A71C23FBE97" modified="2018-12-05" version="1">MEGVTIGTLANVRIITEKRDNAIKIPRSGLRSYLGRDFVRVLEDGSKLREIDVEIGITGSTEVEISKGLEEGQIVVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTE9</accession>
    <name>A0A398CTE9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000005">
        <property type="protein sequence ID" value="RIE05440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05440">
        <property type="protein sequence ID" value="RIE05440"/>
        <property type="gene ID" value="D3H35_00470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039650">
        <property type="entry name" value="HdrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498">
        <property type="entry name" value="PTHR43498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="415" mass="47613" checksum="962C66635FE683D3" modified="2018-12-05" version="1">MYAADYTSRHYHSDGIYQIPYRSLYSFNVNNLLFAGRNISATHIAFGSSRVMGTCASVGQAAGTAAALCVENKATPREIYEKHLKQLQQTLLWEDASVIGIKNEDPADLALQAEVTASSYLSRLAVESADEAFELATDVAFLMPVDPNIEKIQILLDAADDTSVEVEVWDTGRQENYIPYQLQVRDVQTIKKGNKQWIEFNLPWSPESTQNAFVVIKENPSVSVYLSHQPMSGVLSFVREKALNVARGMESLNHDQLVVKWNMKRVVRKPFCFRLATETKAYEPAKIMDGYQRPYGGAHMWLSEPSKDDAWVALKWDKEVEFNEIHITFNDDVNEDLINLHHHRTEFDVIPELVRDYRLEVFEKGNWRILFEVKGNRQRKRKHTLENDVRTEQLRLVVEQTNGTAYAEIVEIRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTL3</accession>
    <name>A0A398CTL3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Signal peptidase I</fullName>
            <ecNumber evidence="4 6">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lepB</name>
        <name evidence="9" type="ORF">D3H35_16410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 6"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02304">
        <property type="protein sequence ID" value="RIE02304"/>
        <property type="gene ID" value="D3H35_16410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="8">
        <location>
            <begin position="33"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="200" mass="22840" checksum="7FEBDA5B0F056BD3" modified="2018-12-05" version="1">MNKEAESLPTPVNRRTRSAAPKRELSGWRKELWDWLRALLIAAALVAVIQTFVFQLSTVKMHSMQPTLFEKEWLFVNKISYELGHPKRGDIVILKDPSIGDGRKKYLVKRVIGIPGDTLEVRNEQLYVNGELQIEPYTDSPIEDGDFGPLTVGAGHYFVMGDNRHLGQSKDSRMFKEVPEKLIQGRAEAVVWPIVRWSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTN9</accession>
    <name>A0A398CTN9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Glutamate racemase</fullName>
            <ecNumber evidence="2 7">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murI</name>
        <name evidence="8" type="ORF">D3H35_20840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Provides the (R)-glutamate required for cell wall biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2 7"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03227">
        <property type="protein sequence ID" value="RIE03227"/>
        <property type="gene ID" value="D3H35_20840"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033134">
        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="41"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="73"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="184"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="281" mass="30859" checksum="3946B6C1866C6F5C" modified="2018-12-05" version="1">MQRAIAVLDSGVGGLTVVKEVMRQLPREKIIYFGDTARAPYGPRAAEEVLAFTREIVDYLSQYKPKMIVIACNTATAVALQDIRARVRIPVIGVINPGARAAIGKSKTGKIGVIGTDGTIKSRAYDHALRCLSPRVEIVSLACPKLVPLVEDGDFHSEETRSIVVESLEALRGVPMDCLILGCTHYPFLSEMISSYMGESVHLISSADETAREISTILHENNQLAGRDERPIHQFFCSGEPRKFQEIAQAWLGAQIRLSPVVWHIPHNGSSYRNGNGRTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUT9</accession>
    <name>A0A398CUT9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_20980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03061">
        <property type="protein sequence ID" value="RIE03061"/>
        <property type="gene ID" value="D3H35_20980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="77" mass="9261" checksum="CB04ED7572948AA5" modified="2018-12-05" version="1">MFKKHIIYKHDNYNMLTVEVQGKTLVVREISDQWGEECHNFISRPEMMEWARRRFRPDDFPGGEEAYNQTIDALRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUU6</accession>
    <name>A0A398CUU6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03071">
        <property type="protein sequence ID" value="RIE03071"/>
        <property type="gene ID" value="D3H35_21035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="68" mass="7668" checksum="B14ED8E0F49908CA" modified="2018-12-05" version="1">MMRCPNCNSKDIGKIGSHQFYCWSCFIELTVNGDKMSVYQVEEDGTLSSLDDLFFEEPMVPQVHAGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV30</accession>
    <name>A0A398CV30_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_07430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04408">
        <property type="protein sequence ID" value="RIE04408"/>
        <property type="gene ID" value="D3H35_07430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="700"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1240" mass="135623" checksum="963B9E6BA052836F" modified="2018-12-05" version="1">MLDVTGFRFDFADEDTEEGALADDIAINDFAAREVSMHDIAIVGISAELPLAEDADHYWRILRDGKDAVASFPKRRRQDVEAYIRRLGLDPETVAYFDGAYLEEIDKFDPGFFRMSPRDASLTSPSQRLFLQTAWKTIEDAGYGGGKLAGTKTGVYIGYCADAIHDYKRLIAEEDPSGVPIAIPGNLTSVIASRISYLLDLKGPALSVDTACSSSLVAVHLACQAIRSGDCDMALAGSVKTLTLPIDTGMRVGIESSDGRARTFGDGADGTGMGEGSAAVLLKPLAKALADGDSVYAVIKGSAINQDGSSAGITAPNAAAQEEAIVQAWLDADIDPSTVSYIEAHGTGTKLGDPIEIEGISRAFRRFTDERQFCAIGSVKTNLGHLDNAAGIVGLLKAVLALKHKELPPSLHFERPNRHIDFIESPVYVNDKLKAWETGTSPRRCGVSAFGLSGTNCHIVLEEAPTYEEQEGTDFYEEGGVFALSARSGESLARSVRKYADWFEERGGSGLNIADLCYTASTGRSHYDYRIAAVVRDGDELAALLRAARNLPPEKFGETGFLYSHSPAAEGSAAVKPIGESGYGQLSAADKLSAENAARELIDRICGEDDIGRSGHSHDKADLERLSALYVQGADIPWERLYAGQRRCKLNLPTYMFDKVRCWVDGDPSRKRSAAQAAGAATASGGMTAAKAAAADAGEELEVDIEEAVAEAWARVLGVRPGPNDDFFALGGHSLSAVQLIANLQQEFGIELSLSEVFRSPTVASLAEAIRDAARNDSDKITPCAPSDRYPVSSAQKRLFILSELHGDNTGYNMPALMEIEGAVDKERLVQALQTIIDRHESLRTTFGWEDGEIVQRVHPAAEPSVEFLEAGPEGIDGAVRAFIRPFQLDRLPLLRIGLLRTDARKHLLLFDMHHIVSDGFSVGKLAGDFARIYGGVELPPLPIQYKDYAAWQEKRFGSESFLEHERYWKRQFAVPAPKLRLPTDRDRTGEAGASAYEGKTVFFRADQSLSRRLEELAASTGTTLFMVLLAAYNVLLSKYSGQEDIVVGSAVAGRTRAELEPLIGMFVNTLALRNYPSKEKSFRRFLAEVKENAREAFEHQEYPFERLAAELGDAVRPGQDNPLFDTMFVHQNTALPELDFGEAKLRPYSYDFGISKLDLTLQSWANGPELTFSLEYRTALFRHDTMVDFSERFLRMLELAAGEEDFALRDADLLEQSERSRIEENIRAGKETVFADFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVC1</accession>
    <name>A0A398CVC1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03211">
        <property type="protein sequence ID" value="RIE03211"/>
        <property type="gene ID" value="D3H35_19885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046239">
        <property type="entry name" value="DUF6272"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19788">
        <property type="entry name" value="DUF6272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="182" mass="20425" checksum="7E19A256438131C8" modified="2018-12-05" version="1">MEDNPLLEVQTVLRRNGILISFSGRLSQQLIEEYGEAVKTYLETDKRPKNEIYHIFSIFIEQTQNIKNYCTSKSESALYDQISSSCIVTIGRETDGNFICSGNLVDNGDLATLISHIEPIINLQKDELKRLYKEKLKQPFDGTSSGAGVGLIDIARKAALPLEYSVTKLDDRVSFFTLKAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVI9</accession>
    <name>A0A398CVI9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">mltG</name>
        <name evidence="9" type="ORF">D3H35_21070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03231">
        <property type="protein sequence ID" value="RIE03231"/>
        <property type="gene ID" value="D3H35_21070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08010">
        <property type="entry name" value="MltG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="412" mass="46089" checksum="88D5616F16CECB8F" modified="2018-12-05" version="1">MASEEKKNGPGEAAAATETYHGLADELTSRVPLERARRSGNPERPPEQKVAYRRRKPRVLLWSFLIALSLVLIFAGSVIFYVWNGLRPVAVSDTPVQVTISKGMRAKKVAEMLEQNGLIRNATLFGAWLKLNDEGSRFQAGDYALTPGMANKTIVAKFNSGETIAAATIRFTIPEGYTIKQMADRIAEAAGVDKNSFLAAANDLTKLNGSIWLKDISANGNLRYPLEGYLFPDTYEMKSGSSETDILNRMLSELDRKLDQLPEDWETVLEERGLTVHQMLTIASLVEREVVIDEERPIVAGIIENRIKKKMPLQIDATVQYLLDKQKEKLLTEDLKVESPYNTYLHPGLPPGPIASPSLQSIEATLYPADNDYLYYVTKKDGTNTHLFASTYRQHQKNIQASEKNEKNAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVQ0</accession>
    <name>A0A398CVQ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD-GYP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03947">
        <property type="protein sequence ID" value="RIE03947"/>
        <property type="gene ID" value="D3H35_08255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="1">
        <location>
            <begin position="113"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="371" mass="41846" checksum="6AE2DAD62E6E8DFF" modified="2018-12-05" version="1">MRMMPISLSRPGMKLAKKIYSDDGIVLLAEGAELTATLIRRLSECGISFLYIQDSLTDDIVVPELLSDETQRKALTAIKSTFREFVDQPARRKSVTYPYIGRNMRQVMGMIMDDLSGNKDAMIMLMNLHTVDHYLYMHSLNVCVYTTLLGIAHGYDTHQLEQLGMGALLHDVGKTQISMQVLLKPGKLSQYEFDEMKRHTERGYYLLKDEPNIPLVAAHCAYQHHERLDGSGYPRGIRGHEIHEYAKWIGVVDSYDAMTSRRIYRDAMLPHQAVEALYSGSGTLYDTQMLSQFRDKVAIYPIGIPVKLNTGQSAVVVDINSACAHRPIVRILTDEEGAALSAPYDMDLSKHLTVLVSEIEMERHDLNPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW83</accession>
    <name>A0A398CW83_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rhomboid family intramembrane serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_12510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03471">
        <property type="protein sequence ID" value="RIE03471"/>
        <property type="gene ID" value="D3H35_12510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="59"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="208" mass="23299" checksum="34F116BC6C38FDAC" modified="2018-12-05" version="1">MLFLRNENFRSYIRFYPVTSIILAINLILFSIDELFLDNRITIWGMFFQEPGYNPYGLSEPWRYVTSIFLHGGWDHLLFNCFSTLVFAPPLERLLGHFRYFAFYLAAGIAGNALSAIVQAGSVHASVGASGAIYGLFGAYLFLAIFRKSALDEGSRKTVYTTLIFGLIYSVVLPNINIWAHIGGGIAGFAMMGLLVSKHRLTENARFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW84</accession>
    <name>A0A398CW84_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-heptose synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04808">
        <property type="protein sequence ID" value="RIE04808"/>
        <property type="gene ID" value="D3H35_04890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="175" mass="20155" checksum="E10F1BBBC1F880F3" modified="2018-12-05" version="1">MSRRFVIEAVMIAIYGQLLLPKRPVEYRIPYSTIMELYDMKDSSDPVMPEAEDDRHVKEKIGEMIAFFEDPFNKKKLERALQGPWKESPPLPINEHVTFVVINAVENMQYGEALDPIETELVLTSLRLQCPILSDQIEFQDKVVQNAVPVQLYDIDDYEFAVEEGIEAPTDGYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWP0</accession>
    <name>A0A398CWP0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04247">
        <property type="protein sequence ID" value="RIE04247"/>
        <property type="gene ID" value="D3H35_06420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024515">
        <property type="entry name" value="DUF3397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11877">
        <property type="entry name" value="DUF3397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="132" mass="14912" checksum="017F94E4943EF2DA" modified="2018-12-05" version="1">MDSVWKSLVDAYAALAAFPVIPFLFVYFVERYRSGDKKRAFRLAMDVTTAFLLGCVGFMLNRRIGSSLGLYFILLLMLIGAGLIGNAQTRLRGKIDVSKIFRAIWRLSFFAMAVLYVLLMSLELIMPSITQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWU9</accession>
    <name>A0A398CWU9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FMN-dependent monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_02620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05048">
        <property type="protein sequence ID" value="RIE05048"/>
        <property type="gene ID" value="D3H35_02620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="4">
        <location>
            <begin position="32"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="154"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="227"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="462" mass="51931" checksum="E1B633EE81C5FE1D" modified="2018-12-05" version="1">MPKRIRLNFIEKNCPTVDNIGMWRHPDSRPELYKELHYWTDLAQLLEEARFDAIFFADALGPFSTYGNSRDTAVREGMSLPINDPLYLIPAMAAVTEHLGFAVTSSITYDHPYAMARKMSTLDHLTGGRIGWNIVTSNLNSAALNFGWREQLEHDRRYDRGDEFLEVCYKLWERSWEDDAVVRDRQRRVYTDPSKVHDIGHEGEFFKVPGIHLSEPSPQRTPVLFQAGSSQRGRLFAAKHAECVFLNAMTPEETKYLVDDIRSKAKEAGRDPADILFFPRFVPVVAPTEREAREKFESYLEQVSTEGTLALLSSWSGIDFSAFGRDELLAFIERKGNGSQYIADYLSRASAERPLTVPDLAKLYAFGGIENVAVGSAEQIAERMIAFADATGIDGFNVAYAIRPASVRDFADLVVPELQRLGRVQSEYEAGSLRGKLFGHGDRLKPGHPGTRTELNANAPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXF2</accession>
    <name>A0A398CXF2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07555</name>
        <name evidence="3" type="ORF">D3H35_07635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04431">
        <property type="protein sequence ID" value="RIE04431"/>
        <property type="gene ID" value="D3H35_07555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04447">
        <property type="protein sequence ID" value="RIE04447"/>
        <property type="gene ID" value="D3H35_07635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033790032" evidence="1">
        <location>
            <begin position="22"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="248" mass="28163" checksum="87537073F07B1468" modified="2018-12-05" version="1">MKNRIILLALMFLIFSGTATASSINGHYKNNPIVLIKSDGKLLQPADVPGILFNGRTLVPIGMLRQLGAIVAWDPNTLSVDVKLPNNSTHTTNDEIALLKFKMKVANTYRIIYQFGAEIQSLTGYFDKTLNAIQINQLPEENLMETEYTIHALTQFCADLKEVKLPIIEEAKKYALDLSDMKDFLDEYYKALNYYSEAYTLLNGYYKTGSKKDLEDKQTALNKAGEVARMPYQYATAKYYDYYNATQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXT8</accession>
    <name>A0A398CXT8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_09630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03804">
        <property type="protein sequence ID" value="RIE03804"/>
        <property type="gene ID" value="D3H35_09630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="69"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="249" mass="27208" checksum="D5D88B89B955A1E2" modified="2018-12-05" version="1">MARLGGYDEKRQDAEDASKLRPGIHGQRIAQPVHRDRRDQAGSPANIRQYVRRRNGGSETLPPLQIPGDKEELHLLFVGRISYGKGVQYLLKAVRHLLDQGCSVSGTIVGDGWYAEKLRALCAQLGIERSIRFAGQVPGTEMDAFYDTADIVVVPSVWPEPAGLVVPEARRRGKPVVVFDAGGLPEWQAHMDGIYVAGHADVANLAQTITDAAFGKPGTRNARAGSGRLDLIDDLRGFIQLIRKEAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYC8</accession>
    <name>A0A398CYC8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TerC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04231">
        <property type="protein sequence ID" value="RIE04231"/>
        <property type="gene ID" value="D3H35_06335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022301">
        <property type="entry name" value="Integral_membrane_YjbE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03717">
        <property type="entry name" value="R_switched_YjbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="237" mass="25637" checksum="AD2A3103894DE993" modified="2018-12-05" version="1">MDFFTDFLTVQFWTALVTIVFIDLLLAGDNAIVIGLAARNLPKENQKKAVIWGTVGAVGIRVVATVIVVWLLKIPFLLAIGGVLLLWIAYKLLVQENEHGDIKAGGTLMAAIRTIVIADAAMGLDNVIAVAGAAHGNFTLVVLGLLISIPIVVWGSTLFIKVIEKYQWIIYIGSGVLAYTAAKMITHEKKFEEFFSDNPVLSWTLIAALTALVIVAGVWTNAIRSRKSAHVRKGGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYF0</accession>
    <name>A0A398CYF0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="10">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">murG</name>
        <name evidence="14" type="ORF">D3H35_00200</name>
        <name evidence="13" type="ORF">D3H35_06495</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="10"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000003">
        <property type="protein sequence ID" value="RIE05461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04261">
        <property type="protein sequence ID" value="RIE04261"/>
        <property type="gene ID" value="D3H35_06495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05461">
        <property type="protein sequence ID" value="RIE05461"/>
        <property type="gene ID" value="D3H35_00200"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01133">
        <property type="entry name" value="murG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="11">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="12">
        <location>
            <begin position="190"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetyl-alpha-D-glucosamine binding" evidence="10">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE04261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE05461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="370" mass="39489" checksum="9369B5FBD6E64721" modified="2018-12-05" version="1">MRVVLTGGGTGGHIYPALAIGRDIKEREPDSSFLYIGALRGLESRIVPQQGIPFEAIHITGFRRSLSFENVRTVMRFWQGVRRSKALLKKFKPDVVVGTGGYVCGPVVYAAAKLGIPTVIHEQNVVPGLTNHFLSRYVKGVAVSFAESKPHFAKCPDVVHAGNPCASAVLRADRKQGFASLGLAPETPFVVVVGGSGGAKALNEAAVRMSPALSALPDVHVVIVTGERFYEETKARIEGLASSSQSRIHVLPYLHNMPEVLAAASLVVSRAGASLVAEITAIGVPSILVPSPNVTNNHQEPNARSVADAGAGEMILERELTGDALFERISAIMGDSDRRAAMSKASRSLGMPEAAAAIYEQIRRVTRQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYS4</accession>
    <name>A0A398CYS4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Elongation factor G</fullName>
            <shortName evidence="7">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">fusA</name>
        <name evidence="9" type="ORF">D3H35_02225</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE04987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04987">
        <property type="protein sequence ID" value="RIE04987"/>
        <property type="gene ID" value="D3H35_02225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="8"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="691" mass="76223" checksum="AE4089590B0E7083" modified="2018-12-05" version="1">MSREFSLQNTRNIGIMAHIDAGKTTTTERILFYTGRVHKIGEVHEGAATMDWMEQEQERGITITSAATTAQWKGHRINIIDTPGHVDFTVEVERSLRVLDGAVGVFSAKEGVEPQSETVWRQADRYGVPRIAYVNKMDIIGADFLNVVKDMKERLGANAVAIQLPIGAENEFVGMIDLIERIAYVYKDDLGKEPVESEIPANLADQVEELRAELVEKVAELDEELMMKYLEGEEITVPELKAALRKGVCEVKIFPVVCGSSYRNKGVQPMLDAVVSFLPSPVDVPDIKGTLDDGTETVRKSADDQPFAALAFKIMTDPYVGKLTFFRVYSGVLNSGSYVVNATKGKRERIGRILQMHANSRQEISEVYAGDIAAAVGLKDTTTGDTLCDEKNPVILESMNFPEPVIQLAVEPKTKADQDKMGIALQKLAEEDPTFRAHTDEETGQTIIAGMGELHLEILVDRMLREFKVETNVGKPQVAYRETFKSAAKVEGKFVRQSGGRGQYGHCWVEFQPVEAGVGFSFENKVVGGAIPREYIAPIQAGIEESMKNGVLAGFPLVDIKAIVFDGSYHDVDSNEMAFKIAGSMALKAAKEKCNPVLLEPIMKVEVTVPEEYMGDVMGMLNSRRGRIEGMDTRHGAQIIRAKVPLAEMFGYSTTLRSGTQGRGVFSMELSHYEEVPKSISEEIISKHKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZN1</accession>
    <name>A0A398CZN1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000011">
        <property type="protein sequence ID" value="RIE05317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05317">
        <property type="protein sequence ID" value="RIE05317"/>
        <property type="gene ID" value="D3H35_01190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014967">
        <property type="entry name" value="Uncharacterised_YugN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036491">
        <property type="entry name" value="YugN-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08868">
        <property type="entry name" value="YugN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160755">
        <property type="entry name" value="SSF160755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="191" mass="21636" checksum="E117427B2752962F" modified="2018-12-05" version="1">MHSLASSLTSRQLEFVPVQDALAEKGFALGGGWEYDHGSFDCALDEANTVFLRIPFDVEVGRLDSETANNEAQIRFGQPFVLRHLYNEGLDSEAQARTLGALFDQFSDPVDPDASIEPAWVEAAGRKLRKWRRSFRFEPAIHIGTIPDDSGTRQCRYLFAVRKNRALYFVRGFMGLSFSFKLILRLEVHYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D067</accession>
    <name>A0A398D067_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_05605</name>
        <name evidence="1" type="ORF">D3H35_19805</name>
        <name evidence="2" type="ORF">D3H35_20090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02870">
        <property type="protein sequence ID" value="RIE02870"/>
        <property type="gene ID" value="D3H35_19805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02915">
        <property type="protein sequence ID" value="RIE02915"/>
        <property type="gene ID" value="D3H35_20090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04564">
        <property type="protein sequence ID" value="RIE04564"/>
        <property type="gene ID" value="D3H35_05605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="107" mass="12595" checksum="8A5A4C664B77A9E5" modified="2018-12-05" version="1">MRLGKVLEEKRMQIVREALSGVKIAVLGRKYEIHPETIRNWVREYGDKVGPDQLPSTDEQIQELKRLQEIEEKYNLALKKLGEKELENEILHELLKKKNPAYLKNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D107</accession>
    <name>A0A398D107_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_05155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04854">
        <property type="protein sequence ID" value="RIE04854"/>
        <property type="gene ID" value="D3H35_05155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="45"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="256"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="329" mass="35701" checksum="A49C2C39D617877B" modified="2018-12-05" version="1">MIETKAQLEDAIAQFETLRQEVGRVIVGQGEVVEQLLWCVVAGGHALLEGIPGLGKTMLVRTVADALDLRFSRIQFTPDLMPADITGTQLVEFGPQGQTSYRFQPGPIFGNLILADEINRATPKTQSALLEAMQERTVTAGGQTHLLPAPFFVLATQNPVEQEGTYPLPEAQLDRFLLKINVTYPTPEELKEIVRRTTSPSLSQAQTIADANLLLKLQGYAKEVLVSDEVLDLAVRVLMATHPTEAGAPEAIVRYVRYGSGPRGIQSIISIAKVKALLEGRLHVSWSDVRSVAIPALRHRLVLGYEGQAAGVSPDELALAAIDAVEATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CC02</accession>
    <name>A0A398CC02_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00686">
        <property type="protein sequence ID" value="RIE00686"/>
        <property type="gene ID" value="D3H35_27025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="72" mass="8105" checksum="3E0D058485FC54EA" modified="2018-12-05" version="1">MSMTSGKKVISGASNERSEDLVFLAELMEAGKIKPVIDRRYPLEQIPEAHSYVDRGHKKGNVVITVEHRNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCW0</accession>
    <name>A0A398CCW0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00543">
        <property type="protein sequence ID" value="RIE00543"/>
        <property type="gene ID" value="D3H35_27775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="520" mass="58961" checksum="7141090277845C4E" modified="2018-12-05" version="1">MTKKTYTVVFAFIFILEVIFGYYVAVHLPYINGDAISRVANAFYVLYSRDPHLAAVGFIWNPLPSFLAMPVLLFQPWLPTLSSAGLSSVIITSAFAGLTAVVLLQAFYKNLGSATFFGIACTLLFVLNPFQFWYGANGMSEALFGFFLLVSVIHWTQWIRDNSVHSLTMVSLMLSLAFLTRYEAIPFSAAIVFATFWYMLAKKSVFAKIESTLLMLLLPVLFTVTVWLVLNYTIMGDALYFLHSSYSNAGQSEFLADNPVMSVLIGNPEASFKFVCKRIAVFAIPYAVLLLFRLLSRTALRWDFLVFTVLTFSIPLFQWYMLYGGLSFGWLRFFYYPLLITIAWLPYELSSNAQPSMARALKPSMLAALAVSAVLVVPVMNNASLSPEEYSVIHYRDSATYQKTLLNRKISQKLDREIFDSDPNALVIADSFNAFEIILNSRNPRRFVNTTDRDFKAVLDQPLKFHVEYLLVPKPEGLSALNAVHVKYPLLYEGNADWAKLVFDIDDRWKLYRIVGEPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEC8</accession>
    <name>A0A398CEC8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_29700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00212">
        <property type="protein sequence ID" value="RIE00212"/>
        <property type="gene ID" value="D3H35_29700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="75"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="282" mass="31540" checksum="722AB5E4DBF9B055" modified="2018-12-05" version="1">MKSSSARKGRFTLFVCYVLLGIISVCCLYPALWVLLSSFREGSSLYSKSLFPSTGTLEHYRELFNSPTLMFKRWYWNTLKISVISMLLGTALTTLVAYAMSRYRFAGRKLSMSILLSLGMFPGFMSMIAIYILLMQLRLLDTHAAIILVYAVGAPIFGTFVAKGFLDSIPKSLDESARIDGASHFRVFFSIILPLARPMLTYLALTNFVGAWVDFIFARLILRSKEQWTVAVGLWDMVSSYQNSNFTLFSAGAVLVAIPITCMFLFLQRFLVEGLTSGASKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF94</accession>
    <name>A0A398CF94_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01250">
        <property type="protein sequence ID" value="RIE01250"/>
        <property type="gene ID" value="D3H35_22940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="155" mass="17706" checksum="A1E5534EAA9045C5" modified="2018-12-05" version="1">MADEIKELGIEVRGIKYERGKIIFQAFGEAARLMRLRCADNVYRIIAEFEVGPHKSDLIQIEIGMKKLNWERLAFEYSRSREICVSASRRGKHAFSRFDMITTIENALARNGFTRAGKDTEGAMCIRADLDGTCCRISIKLTDAAFRFRGMIVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFN8</accession>
    <name>A0A398CFN8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pyridoxal 5'-phosphate synthase subunit PdxT</fullName>
            <ecNumber evidence="4">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Pdx2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pyridoxal 5'-phosphate synthase glutaminase subunit</fullName>
            <ecNumber evidence="4">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">pdxT</name>
        <name evidence="7" type="ORF">D3H35_23355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="4"/>
    <dbReference type="EC" id="3.5.1.2" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01320">
        <property type="protein sequence ID" value="RIE01320"/>
        <property type="gene ID" value="D3H35_23355"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PTHR31559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="L-glutamine binding" evidence="4 6">
        <location>
            <begin position="46"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="4 6">
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4 5">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4 5">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="197" mass="21310" checksum="9840EE99EDA7C692" modified="2018-12-05" version="1">MKIGVLALQGAVAEHIRSVELAGGVGVAVKRTEQLAEIDGLIIPGGESTTIGKLMRKYSFIEALREFHEQGKPLFGTCAGLIVLANRLEGGEEAHLGLMNMTVARNAFGRQRESFETDLPVKGIETPLRAVFIRAPLIKEVGAEVEVLSTYDGEIVTARQGNLLASSYHPELTDDYRLHGLFLDMARKAAEAAPKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGD3</accession>
    <name>A0A398CGD3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF541 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01012">
        <property type="protein sequence ID" value="RIE01012"/>
        <property type="gene ID" value="D3H35_21400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="256" mass="26891" checksum="6AA1D61E80F2C3C8" modified="2018-12-05" version="1">MKQRSWQVLTVALAVVVIGWIGFGKGEGTIVAAETPTTASAQSAVVNTVTVGASGSILVEPDVAYLNVSVDSQGTTANAAQKANADKFAAVEKALYEKYGISKKDVKTTGFYVQPEYNYTEKEGRKLTGYNASHSLQVTYRKLDGIGKLLDDLTAAGANRTDGVQFSTEKKDQYELDALKQAMANADAKAGVLAVSAKRQLGGVLNIVQGNAQNVPVIMYDQVAKVASESGASASSSVQVGQIEISASVTVQYGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGL0</accession>
    <name>A0A398CGL0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_24945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01595">
        <property type="protein sequence ID" value="RIE01595"/>
        <property type="gene ID" value="D3H35_24945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017212640" evidence="2">
        <location>
            <begin position="31"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="222" mass="24788" checksum="D3F61BDD654B105C" modified="2018-12-05" version="1">MVRGNRLKKRRLLILACACVMISGCTTSNENTNTQTSGSPAALSSQVSDPSIADMTNEDLDVTYNGIILNDQIPFEELTSKLHLSMEENNESITTRVAGEAKGKDYAWYQVSYPNKENTDFIFDYLYNATDKSGRIVSIKLIKVPTKRGISIGDSLEKTKEAYGKNLVSEPETETTNSLAFLVENKGISFTYDKKTEKMVDIFIDYDSNKAMDEMDIPSLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGV2</accession>
    <name>A0A398CGV2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_24100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01685">
        <property type="protein sequence ID" value="RIE01685"/>
        <property type="gene ID" value="D3H35_24100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013571">
        <property type="entry name" value="Tscrpt_reg_QacR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08360">
        <property type="entry name" value="TetR_C_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="198" mass="22550" checksum="48110004E5F77293" modified="2018-12-05" version="1">MNKKKIQSEQTKKRVAEAAKSLFVQKGYKATSIEDIVNATGSSAGNIYYHFKSKEGLFLYLIGEWDREWEEKWQVKEPLYSTSVDKLYGLAEHLVLENLNHPLTKAADEFFNNAEKASDAEEKISEMMAGYLRFNQKLLRQGIENGEFAENNVESLAIILDSLLIGLSQHSRKLKREDALALYKSAIDVFILGIGRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH99</accession>
    <name>A0A398CH99_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_13755</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01850">
        <property type="protein sequence ID" value="RIE01850"/>
        <property type="gene ID" value="D3H35_13755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0680">Restriction system</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="7">
        <location>
            <begin position="65"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="337" mass="38650" checksum="00FFCB7282248339" modified="2018-12-05" version="1">MTETADPTKQRAGRNRTLTLDGAEREIYKKRLITLDRPASPEELTDKTVHQDLFAALDFLPAEFVDLLFVDPPYNLTKTFNGKTFSRMDNEAYTEWLDSWFSKLVRVLKPNGSVYICGDWRSSSAIFDVASRYLKIQNRITWEREKGRGALANWKNASEDIWFCTRSSEYAFHVDRVKMKRKVLAPYRNDAGTPKDWGDEEDGKFRLTHPSNLWTDLTVPFWSMPENTDHPTQKPEKLLAKIILASSEEGGVVFDPFLGSGTTSVVAKKLNRRYVGIETDETYGCLAEKRLAIADREPAIQGYSDGVFWERNSLQEQTMQKRRRPSKDDGESIINAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHL9</accession>
    <name>A0A398CHL9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine kinase</fullName>
            <ecNumber evidence="1">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_16230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02273">
        <property type="protein sequence ID" value="RIE02273"/>
        <property type="gene ID" value="D3H35_16230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="4">
        <location>
            <begin position="459"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="398"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="661" mass="74798" checksum="EC2D79B71D55A251" modified="2018-12-05" version="1">MKRSRLSSLLWLLVVIGVLGLFLPSIFSFKENQVDQARTQTAFFSKNWKVFYGAEPGPNSKWLPFDRSEQGKLTGYKGTVWIQRTLPKLNWADPHLFLSGMNHFEARLDGVLVYRYQMDRERSWNHFLMTQHPISLSPSDEGKLLSIKMEWDGLPFGWGLWAYAGNPDQIIVNMLRLDFFYYIYSILCIGAGLTGAVLFFKKRFDKLFLWFSILALSAGFGMLLLCQSLQWLANVEPLYYWRDLFLPLGVFAFTAFYGEALGGARRLSFRIAKGALSAFAALAFAVALWSPYWYWTLLVDSLPFITLAALSVVTFNLLRPSAKSVSSDNRKWLLRGYVVLLVAGLVHMTASMLPSFMESVAQAAPHLFNMAGNMLANGLLLFMLCMVMVLVNYVRNVYRVSERNAEELREKNAELERFHRDLETLVEIRTSELELANRSLSATLREKAETLAEVSVLEERNRIAHEMHDVVGHTLTAAIVQLEAAKKLAVRDGNLSMEKLGTVSSLVRKGLDDIRRTVRVLKTDEMSFQLDSALRELIKETIETMEVDVRADIQLPPVLGKLSEKVVYHALQEGLTNGIRHARCSRFSFELRPEENMLLFRLWNDGIPFGDSKPGFGLTSMMERVHLLGGTVYIGSAYGIEGHANGCELILTLPITDPLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHM0</accession>
    <name>A0A398CHM0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1700 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01930">
        <property type="protein sequence ID" value="RIE01930"/>
        <property type="gene ID" value="D3H35_14240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012963">
        <property type="entry name" value="DUF1700"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08006">
        <property type="entry name" value="DUF1700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="179" mass="20029" checksum="EA30129BD0100059" modified="2018-12-05" version="1">MNRQEYMELLAYYLSSLPDEEREELLRDYDAHFAFGLQNGKKESDIAQELGNPAEIASEIVGPGFSAPVRRPGPDAARMTGVSIMLFFVHLVMLPLAVAFWSLFVAYCAVTLAFILSPVAFLLDLLLYGDYYQTKLFVSIGVMGVGMLLATFLPAAFRKWSKVSIGYGKWVARTWRGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHS3</accession>
    <name>A0A398CHS3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00428">
        <property type="protein sequence ID" value="RIE00428"/>
        <property type="gene ID" value="D3H35_28890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="123" mass="13570" checksum="37B22C03049A6E9E" modified="2018-12-05" version="1">MNAQSLRPMKQHPRQRAARRKPPAARIKYAMLEALSELGDAEPAVLAESLNVPVQSVRKVSQRLIVSGLVRLSGDAVDDRLVITPNGKLVAESARKERRKRLERNSGATAAMDKEPSRRNPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHX1</accession>
    <name>A0A398CHX1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02040">
        <property type="protein sequence ID" value="RIE02040"/>
        <property type="gene ID" value="D3H35_14850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011801">
        <property type="entry name" value="Swm_rep_I_cyn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028059">
        <property type="entry name" value="SWM_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13753">
        <property type="entry name" value="SWM_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02059">
        <property type="entry name" value="swm_rep_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="422" mass="43529" checksum="E4C038BF8F19B761" modified="2018-12-05" version="1">MNFNRELAALPSNANSLFYVTAGSSRISVSSATLSGSMLLLLLPSQPSVSGAITVSYTPGSIPIRDLAGNTLAAFAGFALTNPNDTTAPVFLTGVANGKKIVLNYDEALRTSPVPAISSYSILSGGKVVSISSVAINGNSVELTLSQSLADGAGVTLTYYPGNSYVADIAGNPAPFISGYSMTASGGSTARLASAVINGNVLSLTYSTPLNTLSSSIPNVSQYTVKANGVTIAVRSVYISGQQVTLSLMSDVQSGQQVLISYTNTGNPLKDTLGQTVETFSNYSVTNQTTGTGVVLPEFLEPDGNGGIRLVNSKAVVTSSGVTLSGKIANKYSIDGDKLYNGFNTIKQGNATQPVLVAQIPETEAGAIVSVNVRSLINAAALVSNGILKVNYGILPSPCRLRPLIIPSSCRAPVTIRTPSNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI23</accession>
    <name>A0A398CI23_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02090">
        <property type="protein sequence ID" value="RIE02090"/>
        <property type="gene ID" value="D3H35_15120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="288" mass="33114" checksum="208F380B82E65AF0" modified="2018-12-05" version="1">MDLSILILNYNTCRLTLDCLQSVYRSETQYRYEVIVIDNASKDDSVAQIRAQFPQSTLICNEDNVGFAKGNNQGMRIAAGKYVLLLNSDTVVRPDTFETMVRFMEEHPQVGASGCKVVLPNGALDKACRRGFPTPSASFYYAFGFSKRFPGNPRFNQYQLGHLDENLDYPVDCLVGAFMLVRKQTIEEAGMLDEQFFMYGEDIDWCYRIKQAGWGIHYYPYTSIVHYKGASARRRPFKIIYEFHRAMILFHRKHYRKRYSPLVNGLVYAGVGLKFLAALLRNKVIPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI83</accession>
    <name>A0A398CI83_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Biotin synthase</fullName>
            <ecNumber evidence="3 13">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">bioB</name>
        <name evidence="16" type="ORF">D3H35_20505</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:22060"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="EC" id="2.8.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3 13"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02986">
        <property type="protein sequence ID" value="RIE02986"/>
        <property type="gene ID" value="D3H35_20505"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="PTHR22976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 13 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 13" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 13 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="53"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RIE02986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="332" mass="36093" checksum="5045858D3F76744E" modified="2018-12-05" version="1">MSTIGVNLEWSSLGQKALNGDRLTVEEGLAVLEANDDELLPLMQAAFNVRKHYYGKKVKLNMIINAKSGLCPEDCGYCSQSIVSTAPVSKYTMLDKETLLAGAREALARSAGTYCIVAAGKGPTERELDQVVEAVKEIRDTMALKICACLGILKDGQAERLAEAGVHRYNHNLNTSKANYPSITSTHTYDQRVETVEKVKTYGMSPCSGVIIGMGETNEEIVEMAYALRELDADSIPINFLNAIPGTPLEKAGRTPAMKALKVLALFRFICPSKEIRVAGGREVNLRTLQPLSLYAANSLFVGDYLTTAGQDVSADHQIIEDLGFEIELNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIB0</accession>
    <name>A0A398CIB0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="6">OTCase</shortName>
            <ecNumber evidence="4 6">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">argF</name>
        <name evidence="10" type="ORF">D3H35_15205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="4 6"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02105">
        <property type="protein sequence ID" value="RIE02105"/>
        <property type="gene ID" value="D3H35_15205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="9">
        <location>
            <begin position="20"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="8">
        <location>
            <begin position="166"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="69"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="6">
        <location>
            <begin position="246"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="282"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE02105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="322" mass="35593" checksum="48ED8E3EFF3BA201" modified="2018-12-05" version="1">MPTQPAAASREEIAAALKGRDFLGLVDYKPEEIRYLIDLAIELKHKQKAGEVYQPLKGKTLGMIFEKSSTRTRISFEVGMFQLGGHALFLSRNDIQMGRGEPIRDTAQVLSRYLDGMIIRTFGHMNVVELARASTIPVINALSDQSHPCQALADYQTVLEHKGRLEGLKVAYIGDGNNMAHSLMMGAAKLGMHFASATPAGYEPDAGIIKISKEAAAETGGRIDVLLDPREAIENADIVYTDVWASMGFEEEQKEREKAFKNYQVNEALTQYAKSDYLFLHCLPAHRGEEVSEGVIDGPHSIIFDEAENRLHAQKAIMAAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIF0</accession>
    <name>A0A398CIF0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_15440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02145">
        <property type="protein sequence ID" value="RIE02145"/>
        <property type="gene ID" value="D3H35_15440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="66" mass="7231" checksum="FBE3F44D72F7F885" modified="2018-12-05" version="1">MQNGTVKWFNADKGFGFIEVEGGADVFVHFSAITGEGFKTLDEGQRVQFNIVQGNRGPQAENVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIF8</accession>
    <name>A0A398CIF8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MurR/RpiR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_17690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02523">
        <property type="protein sequence ID" value="RIE02523"/>
        <property type="gene ID" value="D3H35_17690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="122"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="287" mass="31100" checksum="1B6B232C3D0D5018" modified="2018-12-05" version="1">MSLLNAIRDSLTDLNPKERELASYLLERPQEAARMTITELARAAGGSTATVSRFCRTLRFQSFAELKLQLAGEIAQPPDSAQYQDIVAGNPLPDIVSAITGNHLRSLTDTTQILDIAQLRKAIEALHAASRIDLYGAATSGIVAQDFFHKLIRIGKAAAVFSDSHMQLTSASSLSASDVAVGISYSGETPETIHALKCAADQGATTISITRFGAGGLTDHASIRLFTSSSEAGMRRGDMASRMAQLHVVDILFTGLVSEHFNEYVPRLERSFQAVRRYTGKEERTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CII4</accession>
    <name>A0A398CII4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_13890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01872">
        <property type="protein sequence ID" value="RIE01872"/>
        <property type="gene ID" value="D3H35_13890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="122" mass="13714" checksum="5F12FB4A2176F4F1" modified="2018-12-05" version="1">MTDSTGATVNQYNPYNGLLTKVTYPDSKSIQYSYDVNGRRNQMIDPFGGNVYYAYDALSRVADVGTARVADVGTAYNDYEAEYTYYGNGLLLQIQRKMTFQARTRTTVFSSIRSRTGKLTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJM8</accession>
    <name>A0A398CJM8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_23710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01379">
        <property type="protein sequence ID" value="RIE01379"/>
        <property type="gene ID" value="D3H35_23710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="260" mass="28984" checksum="27CFF0D398B4D2E3" modified="2018-12-05" version="1">MIESAAKAGEIEIKGVGKTYRTGKSVFRALDEIDLTIGANEFVTILGPSGCGKSTLLRIVAGLEEASEGELSVDAESIVGPGADRGMVFQGYTLFPWLTVRQNIEYGPKLRGVPILDRRKISNHYLRITRLESFANHFPKQLSGGMKQRVAIARALANGPKVLLMDEPFGALDAQTKLEMQEALLEVWDKEKTTVLFITHDIDEAIFLSQRIVVMAAGPGRVLREYRVELPAERTPEVREHPDFMKLKRELASLLKHREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK38</accession>
    <name>A0A398CK38_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_18595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02670">
        <property type="protein sequence ID" value="RIE02670"/>
        <property type="gene ID" value="D3H35_18595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="178" mass="20385" checksum="3F43441F67FA0CD4" modified="2018-12-05" version="1">MTPREDSTINRKEQILDAAAALFAEFGYYKTTTAEVARAIGVTQPYVFHFFKSKEALYLAVLERASSLIMQAFATVDAPAELLSERMGQAFVELLDDHRNEIMLVMMAYATPEPAIREYTRREFDLVFERVKERFEIAGITEPERSAQLFFGYGLIISMSEALNLPKLCPWNERRGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK44</accession>
    <name>A0A398CK44_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplT</name>
        <name evidence="7" type="ORF">D3H35_10275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03676">
        <property type="protein sequence ID" value="RIE03676"/>
        <property type="gene ID" value="D3H35_10275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="119" mass="13752" checksum="F2BA8A4DA0F45215" modified="2018-12-05" version="1">MARVKGGFVTRRRRNRMLKLAKGYWGAKHRLFKKAKEQVMKSLMYAYRDRRQTKRNFRKLWIVRINAAARQNGLSYSKLMHGLKLAGVEVNRKMLADLAVNDISAFNSLAGVAKEKINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKH7</accession>
    <name>A0A398CKH7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_19775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02865">
        <property type="protein sequence ID" value="RIE02865"/>
        <property type="gene ID" value="D3H35_19775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="396" mass="46230" checksum="35C55BD8D7AAF960" modified="2018-12-05" version="1">MTTIPENMLNDLFENLVTQFVKQNIETIMRAEIKHMLEEQEEHQRNSRNGYYTRTLHTKYGHIEDLQVPRDRNGQFQTSVFEPYQRRDGWLEEAVIQMYKSGMGTRDVARFIESMFGSQYSPTTVSNITATVLEDIQIWLQRPLKKRYSVIYLDGLYVKLKRGTVSGEVVYFAMGIDEDGHRQILGFYIGGQESSNGWREVLKDLYKRGATDVLLGVFDGLTGLEAAFRETYPKADVQHCVVHKVRATFPKIRVQHRTQVIEDIKTVYTAEDKDLALAAFDTVYAKWGKLYPKEMELWKEQLPTLLTFYKFPSLIKEAIYTSNPIERMNKEIRKRLKPMNSLTNMDAAEKIVYLQAIDYNERNESRAIRGFADPEVKKRLTEMFEARYSDKITSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKM0</accession>
    <name>A0A398CKM0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02692">
        <property type="protein sequence ID" value="RIE02692"/>
        <property type="gene ID" value="D3H35_18725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="SSF50985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="158" mass="17589" checksum="AC6090F32BA61298" modified="2018-12-05" version="1">MIQIVSFDRGLDNEEERHVRLGETCFFVMRHFRFGCAIACNESRRGARGIRFQCSGGAEDCDCCGREPLACSERGRNGMDMGRERIRPARGGRVGRQTYAGSSGWIKRNCRHCRRLCHSVALDGEGNVWTWGRNDFGQLGDGTKTNRFVPAKVAGIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKT1</accession>
    <name>A0A398CKT1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_24350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01488">
        <property type="protein sequence ID" value="RIE01488"/>
        <property type="gene ID" value="D3H35_24350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004761">
        <property type="entry name" value="Spore_GerAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34975">
        <property type="entry name" value="PTHR34975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03845">
        <property type="entry name" value="Spore_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00912">
        <property type="entry name" value="2A0309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="372" mass="41161" checksum="259AA95E8383D450" modified="2018-12-05" version="1">MQKISTFQAVSLLINTVMPTAILIVPAAAIAIASQDAWMSVLLAVVYGVLLVLLYGAISKSNRRARPFLEFVRERLGWPTAIAVGFILFINYLTMTAGVLREYINFLSDEVLPKTPGYILCVLTLIVVLYSVSHGLEVIARTSAVVFAVSYLSMGVTFGLLLSMAHWSNLLPPSGIDANKIILGSLPSSNWLSEASFLLLLAPYLSKAGDARKTGLWAILSSGALLLSIIVLTITVLGPDLPRMLTYPTFMIIGMLQYGTFLQRIESIFIAVWIFTVYVKLAVLMFGTVHTFVHTFRIRSVRPFLIVLGLIVMFIALFEWPDTLSSYEFNQSTMTTSFFFYNAIIPMLLWIALLFTKDRTGKGGEEIAKKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKW9</accession>
    <name>A0A398CKW9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dabb family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03035">
        <property type="protein sequence ID" value="RIE03035"/>
        <property type="gene ID" value="D3H35_20815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="95" mass="10748" checksum="F83FB7A0E15C854C" modified="2018-12-05" version="1">MITHIVLFKLKDGSPESVERTAQVLRDMEGKIEQLQSIEVGIDVIHSERSYHIGLVTRFASMDDLNAYQIHPVHKKVIEHMSSVREASASVDYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL74</accession>
    <name>A0A398CL74_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02962">
        <property type="protein sequence ID" value="RIE02962"/>
        <property type="gene ID" value="D3H35_20380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="46"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="265" mass="30265" checksum="EFDE6626593C6D55" modified="2018-12-05" version="1">MDYRTDTDNFLHTNPSLYLAFNGEHDSSMAHFIHTLLIEYKAGKKVLDVGSGPGREVAYLNSVGYEAVGLDNSEAMLSWAREHYPGSKFVLGDQSDFSLQQMFDALYCVGSTFLYNFTNEEVLASLQCFRKHLRPGGLLYLDMRNAAFFLTKEGQCWLTEELVEQREANGTTVSLKTRFSIDLAAQMLERDYCWTVAGYDPIEEHLRHRLLFPQELAHYLAVSGFRLVQLFDKPAPHVDSFDRDRPLTYSHDLLGTRMQIIAQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLC1</accession>
    <name>A0A398CLC1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_27160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ArsB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00647">
        <property type="protein sequence ID" value="RIE00647"/>
        <property type="gene ID" value="D3H35_27160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02040">
        <property type="entry name" value="ArsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE00647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="185" mass="19820" checksum="FA1EA583E71EF7A0" modified="2018-12-05" version="1">MTLFLSILVFAIVIVLVVARPKGLNEAAFALPGAAILLLAGAIGWNDVSSIWAMVWNATLSLIGIMVLTALMDQIGFFRWAALHIVRKFHRRRLLLLGGLAAMSGLIATFFNNDGAILIMIPIVLEATALLGMGTKARIAFLFTVGLMADTASATLVVSNLTNILTADYFSISFGNMPGVWRSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLG4</accession>
    <name>A0A398CLG4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_11200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03265">
        <property type="protein sequence ID" value="RIE03265"/>
        <property type="gene ID" value="D3H35_11200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="385" mass="42181" checksum="F81279C78030DB3C" modified="2018-12-05" version="1">MGTRTRSWLRRWRDDGRNGTCGRSAPKRFIASPEAQIVAHRDRSDEIVEPLWWMTVVSVALALVVCGIFIWANGMNPLAVYKKMVVGAFGTSFGITETLVKSIPLLLCGLGVSVAYRISVWNIGAEGQFALGAIFATSVTIYFPEWPIYLSIPAMVVMGILGGGLWGLLTAIPRTYFQVNELITSLMLNYVALLLLDYFVFGPWKDPKGFNFPARRCLTMRSRCRFSAIPVFILALIFALLAVGLYAFMIRYTRWGYELRLIGSNPEAARNAGIRINRHILLVMIISGGLAGLAGMSEVAGVTHRLMYGISPGYGYTAIIVAWLAKLNPVGLIVSSFLFGGLIVGGYSVQTLGIPSSISSMLQGAILFFLIAGGTISKFRLRRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLJ1</accession>
    <name>A0A398CLJ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_11435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03295">
        <property type="protein sequence ID" value="RIE03295"/>
        <property type="gene ID" value="D3H35_11435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="120" mass="13334" checksum="0282929720DD93A8" modified="2018-12-05" version="1">MANRILIVDDAAFMRMMIRDILTKNGYEVVGEAQDGAQAIEKYKELHPDLITMDITMPEMDGITALKEIRKMDTNAKVIMCSAMGQQAMVIDAIQAGAKDFIVKPFQADRVIEAIKKTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLK8</accession>
    <name>A0A398CLK8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DeoR/GlpR transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_21295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03112">
        <property type="protein sequence ID" value="RIE03112"/>
        <property type="gene ID" value="D3H35_21295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="39"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="126" mass="14411" checksum="F545563A56473969" modified="2018-12-05" version="1">MLSVYCKRFENFSNMVLCRFIGGEHMDTLQEKAKYGLIPVERRKQIVAYVMKHESAQVKELAELFDEVSEATIRRDLELLATEGKLTRTHGGAASISTRTAFEQLYLDKCAMAVDEKRRIAKLLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLN0</accession>
    <name>A0A398CLN0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="9">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hisS</name>
        <name evidence="11" type="ORF">D3H35_27825</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="9"/>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00551">
        <property type="protein sequence ID" value="RIE00551"/>
        <property type="gene ID" value="D3H35_27825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="20"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE00551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="429" mass="47504" checksum="E6FA0565639F6C0E" modified="2018-12-05" version="1">MAFQKPRGTQDVLPGSSGTWQFVERTARDVCRRFGFGEIRTPIFEATELFKRGVGETTDIVEKEMYTFTDRGDRSMTLRPEGTAGVVRSYVENKLYGEPDLAKLYYIGPMFRYERAQAGRYRQFHQFGVEAIGSSDPALDAEVIALGYSFYRELGLTGITVEVNSVGTPEVRAAFRAKLLEFLEPMRGELCEDCQSRMDRNPLRVLDCKVDQAKFEGAPSILDSLDEECERHFAAVKEHLDAANIPYLVNPRMVRGLDYYTHTAFEYKAQGIGSIDTIGGGGRYNGLVAEIGGDDRPGVGLGLGLERTLLLLESQGVKPNVEAGVDLFVIPLGERAEKAVTGIVQQLRLEGIAVERDYQGRKLKTQFKAAERAGAAFTVVIGDDELDKGEVALKPLKETASGEQRLVPIAELARTIRISIQDEKGNNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM07</accession>
    <name>A0A398CM07_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar basal body protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_11410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03290">
        <property type="protein sequence ID" value="RIE03290"/>
        <property type="gene ID" value="D3H35_11410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="3">
        <location>
            <begin position="5"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="4">
        <location>
            <begin position="190"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="275" mass="28552" checksum="7963ECE0E3CE4B81" modified="2018-12-05" version="1">MLRSMYSGVSGMRGFQTKLDVIGNNIANVNTVGFKAGRVMFKDILSQSMSGVTAPVEGTSGGINAKQVGLGVSVASIDTIHTAGSAMTTNVPTDLRIDGDGFFVVSPGEDGAQYLTRAGNFTFDANRQLVNADGMFVLSSEDSGGGPITLDEGVTAFSISQDGQIISVDAEGNAEPTGIFIGVAKVVNPSGLEKVGGNLYRMTPNANPDGALEIGSAGNTETGTGAIIAGQLEMSNVDLTNEFTEMIVAQRGFQANSRIITTSDEILQEVVNLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM56</accession>
    <name>A0A398CM56_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_26410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00731">
        <property type="protein sequence ID" value="RIE00731"/>
        <property type="gene ID" value="D3H35_26410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024232">
        <property type="entry name" value="SpoIIIAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038503">
        <property type="entry name" value="SpoIIIAH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12685">
        <property type="entry name" value="SpoIIIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="231" mass="24980" checksum="75EFDDC9C58A6A30" modified="2018-12-05" version="1">MNNKRQTIWLVSMLSLMVILSAYYLFTEDVSPSQNASGTKSQAEQTDATKTSGTTVDGVTVTEVDSQEGTESTGTTAGGESDGKAQGEASGAAATGDSTDASQKKDEAVIKKLGSEYFDKLQMEQNERFSKLHEQYLAVIADTKSNTPEEATMAAEESMRLEDLDARMTSLEDKLLLDYGNAVVTQDENNFSVVVEAEKLEKKQAVSIVSLALKELNVTPDRVTVQFVAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM75</accession>
    <name>A0A398CM75_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01908">
        <property type="protein sequence ID" value="RIE01908"/>
        <property type="gene ID" value="D3H35_14100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="291" mass="31577" checksum="32BAEA3E3E63CC32" modified="2018-12-05" version="1">MKPLQDRIAVVAGSTRGAGRAIAVELGAAGATVYCTGRSTRGNPSDIGRSETIEETAAMVTERGGRGIPVRVDHTVEEEVAALFERVKTEQNGRLDILINDVWGGEKLTEWGTPFWEASLDKGLLMQRRGVHSHMITSRYGVPLMVARGAGLVVEVTDGFDYRYRGNLYYSVAKTSVIHLAEGMAAELRPYGVAAVSVTPGFLRSEEMLDHFGVTEANWRDAAKQDPHFLQSETPALVARGIAALAADPDLFAKTGRICTSWGLSDEYGIADADGSKPHWGRYAEEQGFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMA3</accession>
    <name>A0A398CMA3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_26630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00771">
        <property type="protein sequence ID" value="RIE00771"/>
        <property type="gene ID" value="D3H35_26630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="121" mass="14393" checksum="182F08A751A0C7F6" modified="2018-12-05" version="1">MSLTAKQIAGNWVNDQLDLYNFAVQLGDAEWQRQILDRLQDRERLIRLEAEHLARLQLWQRFDEINRKILHIYDELRMNASAEVQQKLREKAWELKMERTLIGKKIQVSSSPLGEMRGISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMF8</accession>
    <name>A0A398CMF8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_21830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01067">
        <property type="protein sequence ID" value="RIE01067"/>
        <property type="gene ID" value="D3H35_21830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="17"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="4">
        <location>
            <begin position="119"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="311" mass="35608" checksum="5A3F9833BD35C741" modified="2018-12-05" version="1">MSMTSRMGELARMEAIEEARVYIAEHYDEAITIDLLADKARLSPKYFGELFKKRFGQSAMDYITEVRIRHAKRYLRETDELLRDIARKVGYSDEFYFSRKFKKEVGFAPSAYLRNSKHRIAVLSPSSIGYLLALGIVPVAAPLDAKWTAYYYHSYASRIPFHLKPGDGDFSEDTETLLKSRPDIVVSHERPSDSGLPDALERSALPLFVPAEQDNWIGKLRRIASFLDKEERCEAWIGAYRHKADLARRDVERLTGKETFVALRLWGNTFHLYCNQGIRDVVYRDLGLNPAYSPPKPTSTTSRPTLLRSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMK6</accession>
    <name>A0A398CMK6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ORF">D3H35_14730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02018">
        <property type="protein sequence ID" value="RIE02018"/>
        <property type="gene ID" value="D3H35_14730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="156"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="204"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="284"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="331" mass="35617" checksum="787C1477109B6391" modified="2018-12-05" version="1">MFSKDIGIDLGTANVSIHVKGKGVVLDEPSVVAIESDTRKVLAVGEEARRMVGRTPGNIIAIRPLRDGVIADFEVTDMMLKKFIERVGGRGMFSRPRILICAPTNITSVEQKAIREAAIRCGAKEVFLEEEPKAAAIGAGMDIFQPSGNMVVDIGGGTTDVAVLSMGDVVTASSLKVAGDKFDAAIMKYIKNKYKLLIGERTSEDVKVKIGTVHLHGRREEIDIRGRDMVSGLPQTVTIYSDEVREALWEPVMSIVAAAKTVLERTPPELSADIIDRGVILTGGGALLDGLDSLLADELKVPVLVAEDPMHCVVKGTGILLDHLDKIARRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CML6</accession>
    <name>A0A398CML6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA uridine(34) hydroxylase</fullName>
            <ecNumber evidence="1">1.14.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA hydroxylation protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trhO</name>
        <name evidence="3" type="ORF">D3H35_10805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + O2 + uridine(34) in tRNA = 5-hydroxyuridine(34) in tRNA + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:64224"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:13381"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136877"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrhO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.-.-" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03532">
        <property type="protein sequence ID" value="RIE03532"/>
        <property type="gene ID" value="D3H35_10805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00469">
        <property type="entry name" value="TrhO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022111">
        <property type="entry name" value="Rhodanese_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020936">
        <property type="entry name" value="TrhO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040503">
        <property type="entry name" value="TRHO_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268">
        <property type="entry name" value="PTHR43268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12368">
        <property type="entry name" value="Rhodanese_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17773">
        <property type="entry name" value="UPF0176_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="124"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="296" mass="34177" checksum="6F433ADAAAE65CB1" modified="2018-12-05" version="1">MSDYRILLFYKYVPVPEAEAFASEHLQYCKELGIKGRILIADEGINGTLSGTIEQTDRYMEDLRRNPLFSDLWFKIDESEGHAFKKLFVRYKQELVTLRYHTKLNPVTDGGGRLKPKEFYEYLGRDDVIVLDGRSDYEYDLGHFRNAIRPDLETFREFPEWIQGNLTEFKDKTILTYCTGGIRCEMLTAVLKNEGFKDVYQLDGGIVTYGKDPEVQGRGFDGNMYVFDERVSVRVNQTDEHILVGKCHHCGNPTDRYVNCTDDTCHLQHLSCEQCEESTQGYCSTECEEHDKATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN17</accession>
    <name>A0A398CN17_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_10305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03682">
        <property type="protein sequence ID" value="RIE03682"/>
        <property type="gene ID" value="D3H35_10305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="17"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="391" mass="43158" checksum="1C23579852C40B80" modified="2018-12-05" version="1">MTEIRVALFTDTYFPEVNGVAKTLERWVAYLRKQGVPCMVFAPSRPWREEKEADVAERLVSMPLFLYPEIRIAVPQTTGIEKKLNDFRPTVIHVATPFGAGVAGRHLALKRGIPLVASHHTHFVRYLPFYNLQWMGRLTWRYLNWFHRPSRKIYVPSRSVLEECSNDGWHGLEIWSRGIDTTLFGPDVDRERLLKDEWMPADRFLVLYAGRLAPEKQPEIAVEAVARFNASTGASAQLVMAGDGPSSDGLKALAAKLGLEVRFLGALPQSRLQKWMAASDVLLFPSPTETFGNVVLEAMACGVPVIGADGGAVPDTIRDGENGLLCESGNAAAFADALVRLYEDASLRARLSAAGMYEAKSRSWDEVFAGLLASMEETCATVSATLDAVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN33</accession>
    <name>A0A398CN33_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_10420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03702">
        <property type="protein sequence ID" value="RIE03702"/>
        <property type="gene ID" value="D3H35_10420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="13"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="5">
        <location>
            <begin position="155"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="228" mass="25205" checksum="FC78DBB810C9FFA8" modified="2018-12-05" version="1">MELPSSTDLERIRILLADDHPVYRDGLTSILRSVPEFEVVGEAETGLEAVALAERLQPDVVLMDVHMPEMNGIDSARAITRASPHIGILMLSMLDDDASVFSAMRAGARGYLLKGSRRREIIRAVFAAADGEAIFSPVIAKRMIYYFDSQSRSAAEEAFPELTEREREALDLIAQGLNNADIAAKLGLRTKTVRNHVSNILNKLQVSDRAHAIVLAREKLKLDEGRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN63</accession>
    <name>A0A398CN63_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_15950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02228">
        <property type="protein sequence ID" value="RIE02228"/>
        <property type="gene ID" value="D3H35_15950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017474480" evidence="2">
        <location>
            <begin position="27"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="256" mass="28160" checksum="A2E9BCE43F335881" modified="2018-12-05" version="1">MVSRHFLGICGSAVLLATMTGCNYTAHFQKSNQDYASRAKNDPKTFQSRSYAPLSSDPEQHKNKYFEYSSVVSRKVDSLPGINTAMVFLTDKNAYVGILTDASATGTRAHGGKEVREQVNSGTMEGVYNVDNGSSKWDNRQLANHYNSYFTHRDVADLSTELRQVIGETVRNAHPRVNQVYISANREYVNQLVEFAKASWGRKPLTPLTNDFNTLVSYVFGLGNEVPLPLYERDHGVNSGAAGSIPSKAPAPSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNE9</accession>
    <name>A0A398CNE9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_09835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03842">
        <property type="protein sequence ID" value="RIE03842"/>
        <property type="gene ID" value="D3H35_09835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024745">
        <property type="entry name" value="Glyco_hydro_44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12891">
        <property type="entry name" value="Glyco_hydro_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BIG2" evidence="3">
        <location>
            <begin position="210"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="3">
        <location>
            <begin position="454"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="823"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="842"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1207" mass="130783" checksum="1678243320C4A70E" modified="2018-12-05" version="1">MARIVPSQREETRMKIKKNALLTGTMAALLLLSPFSPASVQKTYGESTGKLVVYDDSLSGQFADYGWAESNLGETGTVHSGDRSIKLDADEGQALYFYKDRVMNAGEYGSFSFWVHGGDSGGQKFKLTFSLGGQAVAEIDSSKLLPQGVPQGEWKQVVVPLEANGVRGIIDGIWVWGSGSQEPFYIDDMLFSGSGSGTGGSNDPQSPEATLAGISFGDNQWVLKTGGLRSAPLNAVWSDGTTNPLREGVVWSLDDESVASVSNGLVTGLKAGTTVLRAAFGDFRAELPLTVVEGQPAPPIEEIVGEYLYDDALASFVSDYSGVAHDLNDGEVVHTGVSSIRIEPNGDSAAYFYSGRPITGKEYEKLRLWINGGEAGGQEITLKLTAGGQPVAEFNAEELVPGGLPAGEWAQVELPLTASQLFDGILIAGAASGAQPAFYVDDIAIISKKAAQARIVELRIDKPRSVLLPGETGQLQAETYFAGGDTGVPSGVKWSSDKPDIVSVDSGELTASAIGIAKITAEYKEFRAEAYVQVTETASELVYEDSLTDGYRNFSWHDKDFANREQAHSGAVSIKFEPDGWDGVWISGDKKLRVEQYYGFRFWIHGGTTGAQKLLFHVYDGQSGLGAVDLSRYFPEGGLKPGVWTPVTVNFADLGLSDGQFDGIIFQASTEDNQGTVYVDDISLLRNLHAGELPEPVLPALGVTIDTSSDRKSVNPEIYGINYDDMHPTESTLSFPVQRWGGNQTTRYNWQLDTANRANDWYYINYPYDNDNPGALPNGSTSDLFIDGVRAKGGQVLLTVPTIGWTPKDREIRSGFSVKKYGAQQSVAQERPDAGNGLRPDGTPITGNSPTDTSKPIGPEFVTGWMDHIKNRTGEGVHYYALDNEPEIWNSTHRDVHPNPPTYDEIWNFTKKYGAAIKAKDSSAKVFGPVSWGWCAYFYSSADVCADGPDRQSHEGAPFLEWYLQQLAKYEKTSGGTRLVDYLDIHYYSQEDGVPTDEEGPTTVKRRFQALKSLYDPNFIDQSWIQEPINLIPRMKDIIDRNLPGMKLALTEYNFGNGRGISAGIAQAEALAIFGREGVDLATRFGTLPAGTPLEDAFKLYLNYDGQGSKIEGTSVKTVSDLPDAVGAYTIEGSNGQLYVLLFNKDTVTREVHVGTGDDAIAGAASMYRFDARQRLSPAGQVSAGEEGKLTVKLPSRSATLLVVPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNF9</accession>
    <name>A0A398CNF9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000028">
        <property type="protein sequence ID" value="RIE04143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04143">
        <property type="protein sequence ID" value="RIE04143"/>
        <property type="gene ID" value="D3H35_07795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="73" mass="8261" checksum="79F90C8EEB2E6013" modified="2018-12-05" version="1">MKPSGDEIAISYNGNGPEALTFLESVLESTLDLSSMEPSVRDTIKIDSLEVLVKLDAQHHWPLSYRIDFRLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNP4</accession>
    <name>A0A398CNP4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01537">
        <property type="protein sequence ID" value="RIE01537"/>
        <property type="gene ID" value="D3H35_24610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017423695" evidence="1">
        <location>
            <begin position="22"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="189" mass="19902" checksum="150851B52CD1738C" modified="2018-12-05" version="1">MMVMAMLFYPGFMLSSIPVSAASTTSIISTIKNVGTQGITSDSLGNVYYVKTSVGSKIYKLSTEGVESEFASLGSTTYQLVTDANDNIYAAANSGLKKIDPQGTVTSISGPTNVTSMALAIDNSGNVYYSDTLTMLKKIDTAGNVTVLASGFNQNMGMAVDSNGNVYVADYTAHVIKKSIRAITIMLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNR0</accession>
    <name>A0A398CNR0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01211">
        <property type="protein sequence ID" value="RIE01211"/>
        <property type="gene ID" value="D3H35_22710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="226" mass="25584" checksum="E9112EC4F9EC0D6D" modified="2018-12-05" version="1">MPTNMTTKTVLFDFDGTLADTLPLSFKAFKAVFEKYDNRIVTEEQLVGMFGPTEDEIIATNLENISEIKQAIQDYYDIYKQGHFDELQQNYEIIDMLRLLKQHEIKIGVITGKSKKAFIISSEALQLSGFFDLAITGDDVECPKPHPEGIFKALDFFETDKNEAVFLGDSNADIKAGKAAGIRTFGVQWLSTYQSSHFEVPPDLIFTNIQQFIRQILEDKSSCTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNR5</accession>
    <name>A0A398CNR5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplR</name>
        <name evidence="8" type="ORF">D3H35_02320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05006">
        <property type="protein sequence ID" value="RIE05006"/>
        <property type="gene ID" value="D3H35_02320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE05006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="122" mass="13449" checksum="C1D0B4E8C8174866" modified="2018-12-05" version="1">MITKGDKNKARLKRHLRVRKKISGTTQRPRLNVFRSSKHIYVQLIDDIQGVTLASASTVDKELAGQVGNGGSVEAARKVGELIAKRAKDKGYENVVFDRGGYLYHGRIQALADAAREAGLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNT5</accession>
    <name>A0A398CNT5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaE</name>
        <name evidence="2" type="ORF">D3H35_20110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02919">
        <property type="protein sequence ID" value="RIE02919"/>
        <property type="gene ID" value="D3H35_20110"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="198" mass="22058" checksum="9B7CD68C8E6B5605" modified="2018-12-05" version="1">MNIGLTGGIATGKSTVAGLLVERGALLIDLDRIAREIVEPGQPSLALIAERFGHAVLNEDGTLNRRKLGEIVFSDPTERKALEAITHPAIRAIMKERLAQYERETPDKLVVVDVPLLYESQLASYFERVMVVYVPRGEQLARLMKRDNLSIEEAERRLNAQMNIEDKKIRADVVIDNGGAPEETAAQIDRFWREAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNZ6</accession>
    <name>A0A398CNZ6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_02960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05106">
        <property type="protein sequence ID" value="RIE05106"/>
        <property type="gene ID" value="D3H35_02960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="240"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="358" mass="41024" checksum="5CA8EEE30AC91B43" modified="2018-12-05" version="1">MNPPCSWLGFIIIRAKIGDDGGSSELFVKKSNPKKRVIMSELLKIDYRAMSPYVRYVHEVELPAGSRFPERYIYDYEFIYVLKGSGTIRIEDRSYSMRGGDLLHIRPHLANEMVVGEEAPMVCSAVHFDYVFLGEGMDFSPYSVYLGRKGEGTESGEESWLGHRPTVELAEIEIPEKMQPSSVQPFFEIFRELRLHFEDPRTDSRLWLKACMLKLIGLIHRELMTKEGVRIGHSHADLVLEAISYMEESYPEPIGVGLLAKRAALTPKYFGTIFRQATGQSVAEYLLRLRMEEAKRLLRQRRFTVQEVGEKVGIGDLYYFSKLFKRVEGISPKKYVDSVSWLERIDTAAFGAEPSAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPG7</accession>
    <name>A0A398CPG7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Urea ABC transporter ATP-binding subunit UrtE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">urtE</name>
        <name evidence="5" type="ORF">D3H35_23725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01381">
        <property type="protein sequence ID" value="RIE01381"/>
        <property type="gene ID" value="D3H35_23725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017780">
        <property type="entry name" value="ABC_transptr_urea_ATP-bd_UrtE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43820:SF5">
        <property type="entry name" value="PTHR43820:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03410">
        <property type="entry name" value="urea_trans_UrtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="235" mass="25801" checksum="CEA4C5695721E241" modified="2018-12-05" version="1">MLSVQQLEAGYGESVILRGVTLSVEPGQVVCIMGRNGVGKTTLIKSIMGLLKARKGSVEFKGSDVTKKAPGIRAKKGIGYVPQGREIFSQLSVYENLRIGLEAVRDKTKRRSRVIPPEAVEKFPVLPAMYGRRGGDLSGGQQQQLAFARALISEPELLVLDEPTEGIQPSIVDDIRDVIRSIRDEGKTAILLVEQSLEFVRSVCDKIYIMEKGSIVWEGGKDDLDDPAVMRYLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPI2</accession>
    <name>A0A398CPI2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_26875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00844">
        <property type="protein sequence ID" value="RIE00844"/>
        <property type="gene ID" value="D3H35_26875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="191" mass="22579" checksum="AADECB336734C056" modified="2018-12-05" version="1">MDEIAKIMDISRVTLYKYFSTKEEIIQIVTTSFIEYFKEMIILDPPNEERLYAARFQQLFEQSVSLSTFITEEYKKDLASVYPEIHEQLYGAIQEREKQLLNFYNAGIRYGIFNEINGQVLILQDQLLNTMLDTRCLLMNHLTIEQVLYDFYKLKKIQLFKPEKLSLVDDSLIVPKIDYLTLKISKALYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPU6</accession>
    <name>A0A398CPU6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000041">
        <property type="protein sequence ID" value="RIE00994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00994">
        <property type="protein sequence ID" value="RIE00994"/>
        <property type="gene ID" value="D3H35_25275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="68" mass="7524" checksum="4FBCCF3F4A6DF0E9" modified="2018-12-05" version="1">MLETGQQIVTAEQFQPRVSKLLASKGGKVLEAPFALTVYLCPSCFAVQHALSESGRDEIVRRMAEEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQB2</accession>
    <name>A0A398CQB2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03499">
        <property type="protein sequence ID" value="RIE03499"/>
        <property type="gene ID" value="D3H35_12690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="384" mass="43103" checksum="A478E25A006EDCAB" modified="2018-12-05" version="1">MLYLAPPYYMINRVSVFRDHEDPLQWYYLPAPPRLTEVTDEQTGVSVPQLQVIQFRSGPDSGGFLNFDVNLGVDPDVLEEIRDEIKRSEHLRESPRLAPVPLIDGTVKLMLFDKQTGDAPSPAGPKISFALSFSHNAKPALYGDNQSAFSVQLTKEGVIALREALQGEMSPIGIIYSLDYLALRPAYSVRLSIDWERVQNHLDETFGSDSIFYQSQITEAVDKLIDNRVIVIEDDLFVVEGEDEGLTARHEQAVDEVRSMITDAFFTPSLNPIEPEKEDTWDKIEHLAKTSSALAVTGGWGSLVSFSYRQIDYTRIDRKRLNVNFSERTAVKKSIYPQGHLSACSNRCGSRHRSEPLRPVGRSDRSLVRAPENPGHFPSRLPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQE7</accession>
    <name>A0A398CQE7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04702">
        <property type="protein sequence ID" value="RIE04702"/>
        <property type="gene ID" value="D3H35_04240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="109" mass="11472" checksum="77D24FB42EC70D11" modified="2018-12-05" version="1">MTTIRLAIVTFHPFAVPGKYKKLPSDKGRKLSIRGTTFIDDASLPRGRPLLLPVTAGAVRLVAGRSGSGGRGHGKFSQPVGICSLVMPGSALFPVEAFRSVAPRCRGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQF7</accession>
    <name>A0A398CQF7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GDSL family lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_04305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04712">
        <property type="protein sequence ID" value="RIE04712"/>
        <property type="gene ID" value="D3H35_04305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="68"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="273" mass="29547" checksum="6D0D92C25AD4CF20" modified="2018-12-05" version="1">MRSNVWLWRILGLTTLVCTIALVGGFGWALKDNWFPSSGLLISDTGQAESPTATGGAWTDKKELIVTALGDSLTVGTGDVNGEGYVRDVTDGLSKALDKPVRLLNNMAVGGLRADELAELLDEKGYRNGVGQADIVLLTIGGNDMFQIAGSGGSVAEGSDLSPELLQQRLPEAERRLASVFKKLRAINPNARIVYIGLYNPFYDLPAMRPASDIILDWNAVAHKLAEADGNATVVPTYDLFETRITDYLSSDHFHPNTFGYARIAQRVVQALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQG0</accession>
    <name>A0A398CQG0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF885 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01234">
        <property type="protein sequence ID" value="RIE01234"/>
        <property type="gene ID" value="D3H35_22845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="410" mass="46041" checksum="9C2FAD12243C4A4A" modified="2018-12-05" version="1">MSSMNLVRQMLKNNRLSILLASGLLVLLTVVGLLWLAQHESEDFDAMIQEIAVATLKDDSEAQLYFGVAEADGIRWDPTKLTGLSDADFKQRNDDAENLLKKLTSYDVAKLSPEDKLTYDIAKWGLRAALQLYSDLNADEYVSLTQFPPYFANNYPIRNEADAENYIAALNGFSDKVAQFIDRIQNKQKKGFVPTSEFLKEMLTSYEKLRKTKPEETILYTLYEEKLAKVKLDPSKEEELKKELLQTLTDHVLTSYGKLADSIKNDLIKQASVSQGIWSQPGGSEYYSARLGVVTGTDLSPLEIHEFAKRKAEEIVKKLRSQTPGQAQEAAANPLLSGNELLQAISGELAKTTLHLSDWFEDELITGNPVDVRSYSVPFSGQVRFISPYPWTAIGTGDFSCRSITRFPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQQ7</accession>
    <name>A0A398CQQ7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="11">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">trpB</name>
        <name evidence="13" type="ORF">D3H35_13235</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TrpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="11"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01761">
        <property type="protein sequence ID" value="RIE01761"/>
        <property type="gene ID" value="D3H35_13235"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="54"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE01761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="387" mass="42754" checksum="5BC5F94BF07464CD" modified="2018-12-05" version="1">MSQQLQQEGYFGEFGGSFVPPELQEVLNYLSAQFYKFKDDPEYNEELRYYLREYVGRQSPLTYVQRLSEAWGGAKIYLKREDLNHTGAHKINNAIGQILLAKRMGAKRIIAETGAGQHGVATATACAMFDMECIIYMGAEDTRRQALNVFRMELLGATVVPVNKGQGRLKDAVDEALDDLVRNYKNTFYLLGSAVGPHPFPTMVKHFQSVISEESKRQILEKEGRLPDAIVACAGGGSNAIGAFAHYIDEPSVRLIGVEPDQAPSLTQGVPSIIHGFKCLVLLDEEGQPKKTYSIAAGLDYPGIGPEHSHLKVSGRAEYATVTNEEVLEAFQELSRTEGIIPALESAHAVAYAKKLAPTMRKDQILIVNLSGRGDKDVEQVFQMLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQW3</accession>
    <name>A0A398CQW3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="8">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">lysS</name>
        <name evidence="11" type="ORF">D3H35_23405</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8 9">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01324">
        <property type="protein sequence ID" value="RIE01324"/>
        <property type="gene ID" value="D3H35_23405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="185"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE01324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="504" mass="57377" checksum="D64B80EFDAC51E08" modified="2018-12-05" version="1">MDQEVQQQEAAELSELLQIRRNKLDELRALGVDPFGTKFVRSHQAGEVLSLYGDLTKEELDEKAIEVSLAGRIMQKRGMGKAAFAHIQDLSGKIQIYVREDSVAANKFAAFDLLDTGDMIGVRGVVFKTKTGETSVKVKELEVMTKSLLPLPDKFHGLKDVETRYRQRYVDLIVNPDVQKTFISRSRIIQSMRRYLDNLGYLEVETPTLHTIAGGAAARPFITHHNALDMQLYMRIAIELHLKRLIVGGLEKVYEIGRVYRNEGISTRHNPEFTMIELYEAYADYEDIMRLTENLIAHIAQEVHGTTKISYQGQEVDLTPSWRRVSMVDLVREATGVDFKQEMSDEEAHLLAKEHKVAVEPHMTFGHIVNAFFETFVEHTLIQPTFVTGHPVAISPLAKKNEADPRFTDRFELFIVAREHANAFTELNDPIDQRERFEAQLTEKEAGNDEAHEMDDDFIRALEYGMPPTGGLGIGVDRLVMLLTDAPSIRDVLLFPHMREERSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR04</accession>
    <name>A0A398CR04_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_03175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04952">
        <property type="protein sequence ID" value="RIE04952"/>
        <property type="gene ID" value="D3H35_03175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="3">
        <location>
            <begin position="13"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="212"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="476" mass="52936" checksum="08EACDD9AEB4C91D" modified="2018-12-05" version="1">MGSTAANIQWRGRCVFGSVVSGRPSEIAGIEQMIGLFINTIPVRIQSRPGMSFSDLVKQVQLSSLSSAQYDYYPLYEIQASSPLEQGLVNHVMVFENYPIEEAIEQSSGQSIGFAISNVEAFEQTNYDFSILILPGKKMTIQFSYNAARIDRGMVARIRGHLQEVIGQVVETPHVHIDQLEIVTEEEKRQLLHEFNDTKASYPADQTIHGLFEEQVKKTPDHTAVVLESESLTYAELNGRANQLARVLRGKGVGADRIVGILAERSLEMIVGILGILKAGGAYLPIDPDYPAERIGYMLEDSGADILLTQKRLEAQTMGFAGEVLHVDDERLYALDDTNLEHTGSSKDLAYVIYTSGSTGKPKGSLTMHRSVVRVVRETNYIDISRNDIILQLSNYAFDGSVFDIYSSLLNGAQLVLTAKTNILDLDKLADVIERHGISVMFITTALFNVLVENEKDNLRNVRKIFLVENVRPFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR52</accession>
    <name>A0A398CR52_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmJ</name>
        <name evidence="7" type="ORF">D3H35_02365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003333770.1">
        <property type="nucleotide sequence ID" value="NZ_QXJM01000016.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A398CR52"/>
    <dbReference type="EnsemblBacteria" id="RIE05013">
        <property type="protein sequence ID" value="RIE05013"/>
        <property type="gene ID" value="D3H35_02365"/>
    </dbReference>
    <dbReference type="GeneID" id="61575014"/>
    <dbReference type="GeneID" id="64220781"/>
    <dbReference type="GeneID" id="66669947"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42888">
        <property type="entry name" value="PTHR42888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="37" mass="4291" checksum="09C9A9E0714F4CF3" modified="2018-12-05" version="1">MKVRPSVKPICEKCKVIRRKGNVMVICENPKHKQKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR65</accession>
    <name>A0A398CR65_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA polymerase III subunit delta</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">holB</name>
        <name evidence="4" type="ORF">D3H35_23895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01414">
        <property type="protein sequence ID" value="RIE01414"/>
        <property type="gene ID" value="D3H35_23895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004622">
        <property type="entry name" value="DNA_pol_HolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00678">
        <property type="entry name" value="holB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="1 4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="325" mass="36004" checksum="77E9D25F263E6911" modified="2018-12-05" version="1">MAFRHITGQERAKALLQNALRSRKIAHAYLFAGPAGSGRRQTAQAFAQALFCERGGDDACGECLSCRKLEHGNHPDFHVISPSGATVKIEQIRELQRELSYRSAGAGYKIYIIEDSETMTVQAANSLLKFLEEPSSPVVAILLAPGPQSVLPTILSRSQLIAFVPGDREALETALVVEGKPPILARTAVHLASGLDSSRKLVEENWFAEIRNVVIQLGRENPSRFPGSLLTAQQLVFKTELAEHVELLLQMMALWYRDMIYAMTGRQNQMVFPDQGDWISKHAWSRSVDAWVSAMEAALTAARRIKAHVQPQLVIEQLLVNVREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR66</accession>
    <name>A0A398CR66_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02317">
        <property type="protein sequence ID" value="RIE02317"/>
        <property type="gene ID" value="D3H35_16495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017468368" evidence="1">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="94" mass="10472" checksum="69D152C167137F38" modified="2018-12-05" version="1">MTRRKLARLTAIILISAALHRSSSDDGKSRCASKRFSNAYQARHGRYGLAKYRMGSRIGVLESLFDEGFEAVRGGCGLRGYPAPKRVQERIKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR69</accession>
    <name>A0A398CR69_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sulfate adenylate transferase</fullName>
            <shortName evidence="7">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">sat</name>
        <name evidence="10" type="ORF">D3H35_02410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05022">
        <property type="protein sequence ID" value="RIE05022"/>
        <property type="gene ID" value="D3H35_02410"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00066">
        <property type="entry name" value="Sulf_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020792">
        <property type="entry name" value="SO4_adenylyltransferase_pro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA_2" evidence="9">
        <location>
            <begin position="5"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-sulfurylase" evidence="8">
        <location>
            <begin position="171"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE05022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="392" mass="43526" checksum="C51EF1875CE321F2" modified="2018-12-05" version="1">MSAILPHGGTLINRVAEGAEREKLLSEAAALTAIPVNAWTISDLDLIGVGAFSPLTGFMNKQDYDSVVNDMRLSNGLVWSIPITLAITSDQASQLSVGQRAALVGEKDGIVYGTIDIDSIYKVDKKHEAVQVFKTNDIEHPGVVKLFDRPDTYVGGSIRVLNRPVPEKFNEYYFTPEQTRQIFAEKGWRTVVGFQTRNPVHRAHEYIQKAAMEIVDALFLNPLVGETKSDDVPANVRMKSYVALLKNYYPEDRVFLGVFPAAMRYAGPREAIFHAMVRKNYGCTHFIVGRDHAGVGDYYGTYEAQDLLRSFPVEELGITPLYFEHSFFCTKCGNMASSKTCPHGKEHHLTLSGTKVRALLREGTCPPPEFSRPEVAEILIDGMAEASKTYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRC5</accession>
    <name>A0A398CRC5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02377">
        <property type="protein sequence ID" value="RIE02377"/>
        <property type="gene ID" value="D3H35_16820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="82" mass="9141" checksum="733C72DA4001635A" modified="2018-12-05" version="1">MKRLEQELAGRALVGANVEVREIGLERLNATIMRSESGIGTKNAEGACLDDIAGVFARTDRIFEADAELYSMYSAWKRVLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRD6</accession>
    <name>A0A398CRD6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_02945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05103">
        <property type="protein sequence ID" value="RIE05103"/>
        <property type="gene ID" value="D3H35_02945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901575">
        <property type="term" value="P:organic substance catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid" evidence="5">
        <location>
            <begin position="62"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="6">
        <location>
            <begin position="141"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="7">
        <location>
            <begin position="507"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE05103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="624" mass="69897" checksum="74D1D5A1CD9637E6" modified="2018-12-05" version="1">MRLAACIADVRLPGKGRCADVASDSCDTDETAGRGSDTGGQSHSGRYGANDERISSRRAARRPGTRYTLRYAEALDRDGNLYTDNLRFARQTDTYVCRSWDRETFEPLFTYHGYRYVEISGSPGPAEADIEGVVVHSCLPETGALETSEPLVNRLIDNIRWTQRANYMSVPTDCPQRDERHGWTGDAMIFAPTAAYNMDVAAFLAKWLNDLEDGQRPTGAYTDFAPFIFGPKTEFDNDFTYTHTGSAGWADAPPIIAWLLYERYGDREVLRRHYAAMKRWMDYNEALYPNGIRRDAPQYGDWLSIDEKPLAETKAEFGWLVDGHSTTPYDVFSSAYWAYGVKVISDIARVIGEEADADKYEKLHACVREAFIREFVNDTAAIKGDTQTAYALALAWRLVPDELREAALRRLVGKIEEAGDMAATGFHGTKHLMEVLSESGYEALAFRLLLREQYPSWLYSVRQGATTIWERWDGWTEERGFQDPGMNSLCHYAFGSVGEWLYRHVGGIRPDPLSPGFGRSVIRPRPLGGLVSTRCEYDSIRGIIATDWTLRDGEFELELTVPANTTALVYVPADEGTTVLEDDRPASQSVGVSAVGREGDCETFLVVSGSYRFKSVYRDGGKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRF5</accession>
    <name>A0A398CRF5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aamy domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03849">
        <property type="protein sequence ID" value="RIE03849"/>
        <property type="gene ID" value="D3H35_09870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="270"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="564" mass="64879" checksum="815C60018BA8A370" modified="2018-12-05" version="1">MEKAVTFGDSRLVYDSASGLPLRWEKEDEALTTFVFPEPFVSLELNGISAANDAEQMIAIRNVMLTGARSELIHDEVKTVSEREKRLVIRTKIDGHWELTTTFLYCGDASLAVSVDVKTTNDSRNPVLRAVRLNLGGFGYRRLDEWELLMPGYIPELTLPIDLHRKLDGCEDRAVFGSRKKDEPGNGTSIMGVYHAESESAMLSWWMSDMFPAVSTMTLIKEEEQLRRESVVYCPCELERGESISIGTFYMSRMKGSRLDALRKAADAFRIYVRSDSQALAGQKTLKICELHIGEKIGRKTFDDYDQIAKKLSYLKSLGFNAIQIMPSFPFPSYSVYDYFNLDKTYGSERGLKNLVRTAKRLGLKVIIDMVLHGPLEKEPASWRMPPGEYEFDSPYLTDRTGWFSRHESGDYARTYTRSFDLANPELRRHISEAIAYYAGSVGIDGVRLDAQTWNFFPNWRPEGGRKPYESIYAGFRMMEEIRKEAKRHYPDLIFYTEGMGPLAAKYHEFRYNYDFHWIYPALSPVRDERGMSTMFWNPASENTLSWSDLAQWLEEQRTTVPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRL4</accession>
    <name>A0A398CRL4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_24705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01554">
        <property type="protein sequence ID" value="RIE01554"/>
        <property type="gene ID" value="D3H35_24705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="64" mass="7372" checksum="A10F4FE7FCB087F6" modified="2018-12-05" version="1">METNLDLINQYVKSVVEKEQLLEKLNLTVLSEQDMHKLMLLTCTINELVGRMVDAGLIQIEIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRU2</accession>
    <name>A0A398CRU2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02507">
        <property type="protein sequence ID" value="RIE02507"/>
        <property type="gene ID" value="D3H35_17610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="273" mass="30924" checksum="9192FF3E7D2CFD2A" modified="2018-12-05" version="1">MEELKHSYELLGLEETATREEVENRYFLLMKRAKSSGTDLSEVTQAYNRIVGIESEKENKTEKQGKVAYFFYYYKIHLIVAIIAVLLIGGTVKSMVDKHNANAKLPPVDVALDLFGGFYQADTERLEQNVLTAAPEWKRVKTTLTYVPAEMKSQQDMALQQKSFLTLMTEKMDIMILDTKNFENLANQQAFKPLEDWEDWLASSRISAERLVAFKAEEDETAHPYGIKLSGSTFFEGTGLPKQSYIIAVRATAAHPEEAKKLLVLLARSEPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS19</accession>
    <name>A0A398CS19_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyphosphate polymerase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05395">
        <property type="protein sequence ID" value="RIE05395"/>
        <property type="gene ID" value="D3H35_00695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VTC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="237" mass="28393" checksum="2729E07F7275BCC4" modified="2018-12-05" version="1">MNTKLKYRHELKYYMNKHQHQIIRRQLKGLLKPDKYAGPEGEYHIRSLYFDDIDNKALHEKLGGVRDREKYRIRIYNRSDKVIHLEKKIKFNDFITKVKEPLSRETYDRIMAGDIEALNVPEKPLLAEMYYQMKNRLLRPKVIVDYVREAYTAITGNVRITFDKQLKTGLNKHNIFDPNLAMINAFDEEVIVLEVKYDEYIPEYIRTAVQTEGLVRQSNSKYVICRKLLKFNTWEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS31</accession>
    <name>A0A398CS31_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_13140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01744">
        <property type="protein sequence ID" value="RIE01744"/>
        <property type="gene ID" value="D3H35_13140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="313" mass="34424" checksum="A2DE8E4A1867C0ED" modified="2018-12-05" version="1">MGTVNSGSFCGHYPIDYRLYLPGQDADFRINCRFREIIMETEEHDSIEMRYRLMNFNNEIAVITGGYSGIGGAAAKKLLANGATCVVLGRSADRANEFIKQLPEYEGKLHFFRADVAEVEELERVIEKIGQEFGRMDMLVNSAGINFRKAAVDYTFADWKRIIDTNLAGTFFASTAAAKVMKRHNGGRIVNIGSMLSHYGVHNVSIYGAAKGGVSQITRTHAVEFADYGIRVNQVSPGYIATPFVDLSLPENLNYRDRLINRTPLGRLGTAEDVANMIAFLLSHEASFVTGQIIAVDGGILGGDPTLNPLMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS44</accession>
    <name>A0A398CS44_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsI</name>
        <name evidence="8" type="ORF">D3H35_02400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05020">
        <property type="protein sequence ID" value="RIE05020"/>
        <property type="gene ID" value="D3H35_02400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE05020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="130" mass="14563" checksum="7F51EB6468C6CB32" modified="2018-12-05" version="1">MAQVQYIGTGRRKHSVARVRLVPGEGRIVINQREIDEYFGLDTLKLIVKQPLVLTETGSKYDILVLTHGGGMSGQAGAIRHGISRALLKADPELRPSLKRAGFLTRDPRMKERKKYGLKAARRAPQFSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSH1</accession>
    <name>A0A398CSH1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_06095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04189">
        <property type="protein sequence ID" value="RIE04189"/>
        <property type="gene ID" value="D3H35_06095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024442">
        <property type="entry name" value="Transposase_Zn_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12760">
        <property type="entry name" value="Zn_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_Tnp_IS1595" evidence="2">
        <location>
            <begin position="19"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="309" mass="35745" checksum="D1E1F9D7AFD1D537" modified="2018-12-05" version="1">MCVSSEDISFDRVRELFNDEQECVKLLFASKWPDGFRCPSCAHRFAYVITTRRMPLYECKACRTQTSLQKGTILEGSRTPLRVWFQAIFLLSRPDSVNAVQLSNVIGVTYKTGWLMYHKIRFAMSDVESRERLSGIVRITDAVYGQRFSGSRDWDAHEQPLFIGSSESETGKITRIIIKKQPEKLPESRFSRPSPAPFLDRYVDPEFEHQAIVSYRFDRQKRNYILLDIASKVEHWLADTFNGIGPKHLDAYLDQFCYMWNRQDQPLFLELIRICAITPTITYPLLTRSSSGRSSRSSRPSTLRSARAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSH4</accession>
    <name>A0A398CSH4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02747">
        <property type="protein sequence ID" value="RIE02747"/>
        <property type="gene ID" value="D3H35_19070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="59" mass="6571" checksum="E6FE638D93B0A6D1" modified="2018-12-05" version="1">MNKFLALIFAFVSIVWMVGTAISLDYNGWLALLFFVLTCATIALGFIVKAKSSRKVQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CST2</accession>
    <name>A0A398CST2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphonate C-P lyase system protein PhnG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">phnG</name>
        <name evidence="1" type="ORF">D3H35_01485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05220">
        <property type="protein sequence ID" value="RIE05220"/>
        <property type="gene ID" value="D3H35_01485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019634">
        <property type="term" value="P:organic phosphonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015716">
        <property type="term" value="P:organic phosphonate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009609">
        <property type="entry name" value="Phosphonate_metab_PhnG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06754">
        <property type="entry name" value="PhnG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03293">
        <property type="entry name" value="PhnG_redo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="141" mass="15543" checksum="12C5F9B488C59182" modified="2018-12-05" version="1">MKRKRRTEILVNGSAEVAAAMADEIRERYEVVVVEEPNHGLVMVKVRETARNSLFYLGEVLVTECKVRIGNAVGVGIVKGDEPLKAADLAVIDAAYAAELSETSAWTARLQSENERLEAERSAAFADLLRTQVSFETMDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSX7</accession>
    <name>A0A398CSX7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetate--CoA ligase</fullName>
            <ecNumber evidence="4">6.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_07120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04359">
        <property type="protein sequence ID" value="RIE04359"/>
        <property type="gene ID" value="D3H35_07120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="58"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="473"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="574" mass="64274" checksum="CD0D886D0106BEED" modified="2018-12-05" version="1">MAPEQEEKLAVTATVSNMASYEEAVESFRWEDVEAQFAWSETGKVNMAYEAIDRHVENGKGDKIALHYSDNNRDESYTFADLARESNRFANVLRKLGVGKGDRVFIFMPRTPELYFSLLGALKIGAVVGPLFEAFMETAVRDRLQDSGAVAIVTTPSLVSRVPRPELPELNHVIIYGDDVAASDGVVDFRQAMAEASDEADVEWLSREDGLILHYTSGSTGKPKGIFHVQNAMLQHYHTGRIVLDLREDDVYWCTADPGWVTGTSYGIFAPWLNGATNVVRGGRFSPQDWYATIEKYKVTVWYSAPTAFRMLMGAGDDAVKPFDLSTLRHVLSVGEPLNPEVVRWGNKVYGQRIHDTWWMTETGGQLICNYPSMPIKPGSMGRPVPGVQAAIIDDQGNELPAFRMGNLAIRTPWPSMMRKVWNNPAKYEEYFRIPGWYVSGDSAYRDEEGYFWFQGRIDDVINTSGERVGPFEVESKLVEHPAVAEAGVIGKPDPLRGEIIKAFISLREGFEPSEELKADISLFVKKGLSAHAAPREIEFKDKLPKTRSGKIMRRVLKAWELNLPTGDLSTIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSY4</accession>
    <name>A0A398CSY4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03868">
        <property type="protein sequence ID" value="RIE03868"/>
        <property type="gene ID" value="D3H35_09980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="246" mass="27989" checksum="8C61F36CB6B0EDBA" modified="2018-12-05" version="1">MEQQSNWHGRWIWKAPSPRAGEGEHETVYFRRTFEVGSTGNCRLLARVSADSRYRLYLNGKSRRRRPLQGRSVHALFRVCRFIGHLVQGSNVLAAQVLHYAVSEPSASAPAVPHPSGGRNRVFIFDGSIQYDNGNETINLHSDENWRYSEDRQFVSSRRIGNALCRGPERVDGSLLPFRWQTAGFDDSGWKKAVVVSEVMMMNVRQLTPWTLTPRPIPDLRNSQRLRTGDAQDRGTKRARVSDVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT36</accession>
    <name>A0A398CT36_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiamine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_07490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04419">
        <property type="protein sequence ID" value="RIE04419"/>
        <property type="gene ID" value="D3H35_07490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="SSF89957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine_BP" evidence="2">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="99" mass="10841" checksum="03FBE5AD3E494FD9" modified="2018-12-05" version="1">MTQALLSIQILPKTKDGEDSIPYVDRAIEIIKESGVSYKVGPLETTMEGEFDELLAIVKKMNEAMFEIGSPSVMSQIKLLVGGPHASMAKLLEKYPDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTC6</accession>
    <name>A0A398CTC6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_15870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02214">
        <property type="protein sequence ID" value="RIE02214"/>
        <property type="gene ID" value="D3H35_15870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50924">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="8">
        <location>
            <begin position="8"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="373"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="569"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="622" mass="69993" checksum="1C60D1E6B3886CAD" modified="2018-12-05" version="1">MDGSGAVFRILFMSLALLISILASYTMFNFIGNLKRTNGTFRQFWLAGGAFVFGVGLWTKHFITMLAFDQEWYFEWSMPVGLFFIIFFSLMAFVMLTFQGVVRHPLLLGSTILAFGIVFLNYFSMLGQPIDKLTPHPVYIFLSIVVIFAGTYFSFRLAEMRSLGYRNMAASLVLGGSAIIVQILGNHALTIEKKTYASVDKLSQDINLMAVIIAVGALLILMSTLVTWYIDKRLNQMDERYRLLVENSLDTIAIFKGDHWGFVNASGMRMFEAEEEKDLLGKSIFSFLPARDHAEVRERLNNLVLIGSGRPLEQEWITLNGKVLHTEIVETITTLDNELAIQVIIRDISERKKNEELLINSEKLYVAGQLAAGIAHEIRNPLTSLKGFLQLIASGRKNTTTYYDIMNSELDRIEDIVSELLMLSKPQVYQLSYHDVRVMMRDTVTLLEAQAILHNIAIESEYGSEPLWVYGVENQVKQVFINVIKNAIEAMIDGGAIRVKLSRENDSVYVRIMDEGPESERISWRRSVSPSIRRRKRERDSASWSATKSSTITKARLRSTASLAEAQCSKSCSRSAIPKPQSKKAADLHGRPRGSSFVPQAPRPRKQAGGGELLLGRISRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTG2</accession>
    <name>A0A398CTG2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">map</name>
        <name evidence="5" type="ORF">D3H35_18125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02601">
        <property type="protein sequence ID" value="RIE02601"/>
        <property type="gene ID" value="D3H35_18125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="12"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="253" mass="27922" checksum="113E5E5DBE47D74B" modified="2018-12-05" version="1">MIHLHGKQEIARMRKAGKLLAACHRELRKLVKPGITTHEIDQFVEKYIRDRGATPEQIGFHGYEYATCASVNDVICHGFPKKEALRDGDIVTIDTVVNLDGALADSAWSYRVGQVSELADKLLRVTEECLYLGIEQARVGNRLGDVGYAIQQHGEKNGFSIVRDFIGHGIGPTMHEEPQVPHYGLPGRGIRLKEGMVITIEPMLNTGSYGVKVDEDGWTARTIDGGLSAQYEHTIAITSDGPYIITDQDENAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU23</accession>
    <name>A0A398CU23_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR00282 family metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_11775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03357">
        <property type="protein sequence ID" value="RIE03357"/>
        <property type="gene ID" value="D3H35_11775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005235">
        <property type="entry name" value="YmdB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36303">
        <property type="entry name" value="PTHR36303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13277">
        <property type="entry name" value="YmdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004789">
        <property type="entry name" value="DR1281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00282">
        <property type="entry name" value="TIGR00282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR004789-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004789-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="264" mass="29099" checksum="4F297F58D77EA6AE" modified="2018-12-05" version="1">MKVVFIGDIVGNLGRDTVKRLLPWLREKYQPHIIIANGENAAGGRGINAAITRELFEWGVHGITMGNHTWDNREIFEFIDDEQRMIRPANLAPGTPGRGSMIVKANGKELGVVNLIGRTFLPPSECPFLAAEELVTELRRKTKCVLVDFHAEATSEKIAMGWHLDGIASLVVGTHTHVQTNDDRILPEGTAYVTDAGMTGPRDGVLGMDKDTVVRKFMNGLPARFTVAEGKWVLSGVFVDIDETTGKAKQVRLIRVDEDSWIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU78</accession>
    <name>A0A398CU78_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_17695</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02524">
        <property type="protein sequence ID" value="RIE02524"/>
        <property type="gene ID" value="D3H35_17695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="133"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="133"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="229" mass="26383" checksum="CD265C0357E857DA" modified="2018-12-05" version="1">MYRIFLVEDEPSLNQVLAAYLRNEGWSVETFHNGQDARDAMKERPHLWILDIMLPGVDGYQLMREIKEDFAKLPVIFISARDADIDRVIGLEMGSDDYLAKPFLPRELVIRTRKLLERVYGKRSEGNGFDDGNPIASLVPYRVDMQARMTFDTDGTALELTSKEFDLLLHLSAHAGQLLNREQLLASLWGEDYFGSDRVVDDLVRRLRKKLPELRLETVYGYGYRLAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUB5</accession>
    <name>A0A398CUB5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03437">
        <property type="protein sequence ID" value="RIE03437"/>
        <property type="gene ID" value="D3H35_12290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="163" mass="18904" checksum="1B0AA3C956BC835E" modified="2018-12-05" version="1">MGTRLLSESLIKSRYPHLRYVRIHTGGSHKATIYAWNEQLQLPEEEIYELKKFASDHLLPYVCFQVKAYPMIRQEQVPPVYELPEPITQAAMSRGLTLYGIVNIINDMFVNGEMTIHKYDSFRGVIHLKVQTATALTDIEKELIRQYLYEMVPLGSCFEVAYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUD7</accession>
    <name>A0A398CUD7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">HlyC/CorC family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D3H35_05295</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0053 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04879">
        <property type="protein sequence ID" value="RIE04879"/>
        <property type="gene ID" value="D3H35_05295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="219"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="283"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE04879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="429" mass="48705" checksum="953E874ABA72553E" modified="2018-12-05" version="1">MGLNLFLVVILIVLTAFFVATEFAIVKLRPSRVDQLVLEGKKNAGAVQKVTSDLDVYLSACQLGITITALGLGWLGEPTIEKLLYPLFDYFALSESVSHMISFAIAFIVMTYLHVVLGELAPKTVAIIKAEQVALITAPIIIFFYKIMYPFIWVLNGSARGFVKLFGMTPVKEHENAHSEDEIRIILSESYQSGKINKTEYGYVNRIFTFDELLAREIMIPRTDMICLYADKSLEENISIIKKEQYTRFPVVNGDKDHIIGIVNTKQFFLNYSDNPSFDYRTVLQPIMAVPEVMPVKTLLKKMQQENVHLAILLDEYGGTSGLITIEDILEEIVGEIRDEFDKDEVTKIQTLGNNRFLVEGTALIEEVNRTIGSNIEDEEVDSIGGWLYSHHPELQVGVEWEHDNCSFTIREKDNRRIRKIEILIKPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUV6</accession>
    <name>A0A398CUV6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03081">
        <property type="protein sequence ID" value="RIE03081"/>
        <property type="gene ID" value="D3H35_21095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="61" mass="6817" checksum="8FAAD28B43BFA6A4" modified="2018-12-05" version="1">MNSGVDDQQWDEVPFFRRLAGRTLISGRGTILSTIAGRTLIRDAHRQWTRYHSSAIGGTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUY1</accession>
    <name>A0A398CUY1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmB</name>
        <name evidence="6" type="ORF">D3H35_07380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04398">
        <property type="protein sequence ID" value="RIE04398"/>
        <property type="gene ID" value="D3H35_07380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="62" mass="6866" checksum="4566C3E3A59A6355" modified="2018-12-05" version="1">MSRKCYITGKKPGSGSNVSHANNHTRRSWGVNVQKVRILVNGKPKRVYVSTKALKSGKVTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVB4</accession>
    <name>A0A398CVB4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ferredoxin--NADP reductase</fullName>
            <shortName evidence="2">FNR</shortName>
            <shortName evidence="2">Fd-NADP(+) reductase</shortName>
            <ecNumber evidence="2">1.18.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_19260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:20125"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferredoxin--NADP reductase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03201">
        <property type="protein sequence ID" value="RIE03201"/>
        <property type="gene ID" value="D3H35_19260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01685">
        <property type="entry name" value="FENR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022890">
        <property type="entry name" value="Fd--NADP_Rdtase_type_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="25"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="346" mass="37665" checksum="F6F128C1D08F4397" modified="2018-12-05" version="1">MRTVSIPFAIILEVYELSSNTELVDVVIIGGGPAGMFAAFYGGMRQMSVTLIESMPQLGGQLAALYPEKHIYDVAGFPKVTAQELVDNVKRQMDLFKPNVCLEEKVLQVTKNDERLFEIVTDKGIHHSRSVIVTGGVGAFEPRRLELPEASRYEKSNLHYFISDLEKFRGQKVVVSGGGDSAVDWALMLEPIAESVTLVHRRDKFRAHEHSVELLMNSSVTIATPKEISALHGESAIERVTLTDVKSGETFDLDVDAVIVNFGFVSSLGPIADWGMAIENGSILVDSRMETNIAGMFAAGDITTYPGKLKLIAVGFGEAPTAINNAKVYIDPNAKLSPGHSSNLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVJ1</accession>
    <name>A0A398CVJ1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AraC_binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_01020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000008">
        <property type="protein sequence ID" value="RIE05329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05329">
        <property type="protein sequence ID" value="RIE05329"/>
        <property type="gene ID" value="D3H35_01020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AraC_binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="122" mass="13424" checksum="E5B313DAECFC19D1" modified="2018-12-05" version="1">MPGSVRVSNGPLGQKTLHAHEGFELYLCVSGSGFYMVGDRLFPLHAGTLTVIPRTPFTALIPLSIIVPSVCAFRRHFVPKAAERRLPDDRTRSSPIAGGRKKHRRKPLFSPHAAIRPCPIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVQ9</accession>
    <name>A0A398CVQ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fe-S cluster assembly ATPase SufC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sufC</name>
        <name evidence="6" type="ORF">D3H35_08330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03957">
        <property type="protein sequence ID" value="RIE03957"/>
        <property type="gene ID" value="D3H35_08330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="259" mass="28657" checksum="503B32024D5DE618" modified="2018-12-05" version="1">MSTQFEIRGLTASIEEKQILKGIDLKINGGEIHAIMGPNGTGKSTLASALMGHPKYEVTGGEVSLNGEDVLEMGVDERALAGLFLAMQYPSEITGVTNADFLRSAINARRGEGNEISLIKFVRQMEAKMKELEMNPEFMHRYLNEGFSGGEKKRNEILQMMLLEPKLVILDEIDSGLDIDALKIVAAGVNAMRDEARGFLIITHYQRLLDYIKPDFVHVMMQGRIVKSGGPELAERLEAEGYDWVKEELGIVDETVGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVW6</accession>
    <name>A0A398CVW6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation protein YjcZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000004">
        <property type="protein sequence ID" value="RIE05459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05459">
        <property type="protein sequence ID" value="RIE05459"/>
        <property type="gene ID" value="D3H35_00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="38" mass="4030" checksum="8C87E51633FCF046" modified="2018-12-05" version="1">MRFHERLCGGAGYGGASSAAFVLVLFVLLVIILKAVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW77</accession>
    <name>A0A398CW77_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-protecting protein DprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dprA</name>
        <name evidence="3" type="ORF">D3H35_11320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03274">
        <property type="protein sequence ID" value="RIE03274"/>
        <property type="gene ID" value="D3H35_11320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041614">
        <property type="entry name" value="DprA_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17782">
        <property type="entry name" value="DprA_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DprA_WH" evidence="2">
        <location>
            <begin position="351"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="412" mass="45606" checksum="12E9057B158A72C8" modified="2018-12-05" version="1">MRERDRQAAFLLLDDKGMEGCLLFVVADSIYSGSRGAEILTDTMERMRRHLIAMHECPGIGRALLSLIVQSGRLEEANEIREREWEDMGLKPHQVQSLLDGFRPERIEMRRRQREKGEMSVVTAFDAEYPPLLLETKDHPWVLYYRGRYELASRPSVAVVGTRVATAYGRHASEMLSAECAGCGLTVVSGMASGIDTSAHWGALEQPGGTIAVLATPVNKPYPYENKELYRKIGESGLLLSETPPDAVLKPYMFLERNRIIAGLALGTVVVEAAKGSGAFRTADRALAYGRDVFVVPGQITSPRSHEIMKWLRDGAKPVIDAEDIWGEYVSQLTELTSLPMSDLLSKSGTTPSPNLSADEASIYELLLDRPRSIDELSASSGMTFGLLHSVLLSLLIKRRIHQEPGFVYSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWE8</accession>
    <name>A0A398CWE8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-glutamate O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_03945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="2.1.1.80"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04888">
        <property type="protein sequence ID" value="RIE04888"/>
        <property type="gene ID" value="D3H35_03945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.155.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036804">
        <property type="entry name" value="CheR_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="259" mass="29719" checksum="82A4148E337E0E63" modified="2018-12-05" version="1">MTEDEDFVRFVADIKRATSIDLSLYKENQMRRRLTTLRLKHGFSSFGEYFAALMSEPRLRNEFLDRMTINVSEFWRNPNRWTVLADKFLPQMLKQSGRLNIWSAACSTGEEPYTLAMILDACGALERTSLLATDIDDGVLAKAKEGSYLERSLRDVPADFRAKYFTAEDGAFRISDKLKKAVRLQKQNLLKDEFATGFDLIVCRNVMIYFTEEAKHDLYGKFARALKPGGILFVGSTEQIFSPGQYGLETADTFFYRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX03</accession>
    <name>A0A398CX03_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_02975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05108">
        <property type="protein sequence ID" value="RIE05108"/>
        <property type="gene ID" value="D3H35_02975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="284"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="813" mass="92085" checksum="86A9957A83082FDA" modified="2018-12-05" version="1">MNEKEIKEMKASTAKLLIYGTDGQKALDSGTAVLIDPYTAITARHVLSRLTEGGRVELSFPHMPSAGSVVVRDVYRCPDELYDIAILKLDEALADGRVYPALYAVKPEGRPSYISHGFPSERSPSCTFEGKIMDIYEQFTQNDLELSVAGREGMNFSGASGSPLYMDGGVYGIIIVRDTGNTLGALSFAECRAFLAEQGIVHHSLKPLRDYERIIVERQLPMAKVGFDEGESLPYMDTYATWENVTSLDNPNRYTLGKPELLSEMVERYFAAEENGENMLFVVADFGKGKSTFLRHMAAKMAGAYRDSREIPLPVYFNLREYTKYEKFGPVLNLNKEGVIKDFLKETTGIDFANRQHPIFSQSILFLIDSLDECGSLSASDVMQVVRSVKAIVDYCRGAKIIVTTRPIPNVLGQVIKEMNDPVNQAWRFASIYGFQPDQFADYMQALHPKLPVESVHAYNRKLLDTIRSGQSIYETFNGLLNEEELKRPILAYMLYKLLEEDYELEKDSKLGIYLSFINLLTKDAKHVDDSGRKDDWLKRLGYRNLLYVTAVMWMKNLHLNGGGFLRLDDLEEALGEDASLVQFMSHSYFKNAGGIYHFNHQSFAEIIIAEYYVRLLLWSALENKTANELSPFLAIGNPTEQTVSFVKSLLNMLCDATIGDDRLDGNSLLKIRRALSPMMSSLGAAEYNRPPDDDKAGNAQRDGYLYSSYIRRVWNAEQWGGFSEISDRMLEQWPIKPEHIEKMIENAAALVNGEDDYVFFQPQRMNHSFNRDVYRIEGRKKTFDPDTERWIAMLCGTTLAERFLGESAFPPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX48</accession>
    <name>A0A398CX48_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dihydroxy-acid dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_01900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05148">
        <property type="protein sequence ID" value="RIE05148"/>
        <property type="gene ID" value="D3H35_01900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009082">
        <property type="term" value="P:branched-chain amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="587" mass="64009" checksum="089C9FBD6099AD6A" modified="2018-12-05" version="1">MGEQKRASDAIADSASAGKLKSEAYFQEKDLWGFIHRSFTKSMGYTEEDIRKPVIGICNTFSELNKCHSHFNELVDYVKRGVWQAGGVPMEFPTISIGEPYVKPTTMLLRNLMAMDTEEMMKAHPIDGVVLIGGCDKTVPAQLMAAASANIPAIVLTGGPMLNGRLGGRSLGACTDCYGFTLEHKAGNITDEELAVAENAICRSDGHCMVMGTASTMASIAEAIGMALPGCAAIPAPDSRRRHMSENTGKQIVELVRHNIRPRDIMTREAIENAITVTMASGGSTNAIIHLVAISQRLGMKLPLETFDAISAKTPFILNLRPSGQYQMEEYFEAGGVPALMKELEPLLHGECLTVTGRTVSENLQHARTYLRDVIRTMEEPLDSQGGIAVLRGNLAPDGALIKQTAVSAHLKKHTGRAVVFESPADLNARIDDPELDVDENSVLVLKNAGPKGAPAMPEIGQIPIPQKLLKKGVRDMVRISDARISGTSYGALIVHAAPEAAVGGTLALVRDGDEIELDIAERRLVLRVSDEELAERRKSWKPPEPHYDRGYGLLFHERVLQANLGCDFDFLLPPELRKEYKERIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXH7</accession>
    <name>A0A398CXH7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">grpE</name>
        <name evidence="7" type="ORF">D3H35_06025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04477">
        <property type="protein sequence ID" value="RIE04477"/>
        <property type="gene ID" value="D3H35_06025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="182" mass="20590" checksum="01751617B3C19948" modified="2018-12-05" version="1">MAEQQEEQVNADAGQAEPNLDEEVAEVEVIEADSLADEYKRQAEENHGRYLRAQADFDNFRRRTQKEKEELAQYASLKLVNQLLPVVDNFQRALQTSGGENGEAGTFAKGVEMIYRQLFEVLENEGLKKMEPVGQPFDPEHHQAIMAVESDEHEEGIVVEVVQSGYWLKDKVIRPAMVKVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXT5</accession>
    <name>A0A398CXT5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04041">
        <property type="protein sequence ID" value="RIE04041"/>
        <property type="gene ID" value="D3H35_08800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="66" mass="7318" checksum="A695A01E83316050" modified="2018-12-05" version="1">MGTIRLRCAAFEAGFFNGFHMPDTLIEELNGFHVPFDRLRALPGVEEAASIRLRQIAGALQLDTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY32</accession>
    <name>A0A398CY32_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="1">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="1">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">mtnB</name>
        <name evidence="3" type="ORF">D3H35_04210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-methyl-5-thio-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04697">
        <property type="protein sequence ID" value="RIE04697"/>
        <property type="gene ID" value="D3H35_04210"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01677">
        <property type="entry name" value="Salvage_MtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="PTHR10640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aldolase_II" evidence="2">
        <location>
            <begin position="17"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="217" mass="24722" checksum="2869FC44BA5663B2" modified="2018-12-05" version="1">MSAFASIPLEEKRRVLEEFTAIKADFASRGWFAGTGGNLSMRIGPYSPDEFFFAVTASGKDKTRSTPEDFLFVDQDGKACETTSLRPSAETSLHREIYRLTGAGAIFHIHSVFNNIVSEWFWERRSVPIEGVELIKAFNIWDEDAAIDVPIVTNYADVPRIVPEITERLDPRIPGLLIRKHGICAWGKDAFEAKKHLEAFEFLFEYVYRWELLKGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ44</accession>
    <name>A0A398CZ44_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_03045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05117">
        <property type="protein sequence ID" value="RIE05117"/>
        <property type="gene ID" value="D3H35_03045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039532">
        <property type="entry name" value="TetR_C_Firmicutes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14278">
        <property type="entry name" value="TetR_C_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="200" mass="23420" checksum="D9442E7250BB9854" modified="2018-12-05" version="1">MSQPEKKVDRRVIRSKEALKQALLKLMADKDFDAITITEIVELSNYNRGTFYTHYVNKEALLDDIIDELIRELLKSYRSPYENQDIFRINELTANSVRIFEHVLHYSSVYAILLRSNVISNLREKMFRALKDVSMNELVYSDNGINPELLANYAIHGLLGLIFYWIESGFAYSSSYMQEQLILMIQWRPTEAKTNVVPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZB2</accession>
    <name>A0A398CZB2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Z-ring formation inhibitor MciZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mciZ</name>
        <name evidence="1" type="ORF">D3H35_05575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04561">
        <property type="protein sequence ID" value="RIE04561"/>
        <property type="gene ID" value="D3H35_05575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="51" mass="5884" checksum="5C30EE9F235DD7F3" modified="2018-12-05" version="1">MLKKYAASHKLQWVGKAWEIRHAIRQEMNRKGGNARLADLLAPKDDRAVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D092</accession>
    <name>A0A398D092_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04891">
        <property type="protein sequence ID" value="RIE04891"/>
        <property type="gene ID" value="D3H35_04075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11531">
        <property type="entry name" value="NTP-PPase_BsYpjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012359">
        <property type="entry name" value="MazG-related_YpjD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42692:SF1">
        <property type="entry name" value="PTHR42692:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029904">
        <property type="entry name" value="UCP029904_pph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="30"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="117" mass="13358" checksum="9640A489A5DED74E" modified="2018-12-05" version="1">MTNRTLSEKSLAQIQREVDAYISQFKEGYFSPLAMLARMSEEVGELAREVNHRFGEKPKKPDEADNSIEMELGDILFIVTCFANSLGIDLAEAHDKVMSKFNTRDANRWTKKNTDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D2Q0</accession>
    <name>A0A398D2Q0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lipopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_00755</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05354">
        <property type="protein sequence ID" value="RIE05354"/>
        <property type="gene ID" value="D3H35_00755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="8">
        <location>
            <begin position="28"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE05354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="276" mass="30533" checksum="D3155BABD46EC109" modified="2018-12-05" version="1">MGCRNINQKILTLISSSPNKFSIGGSGLELQRYWSVVRKRLWLIALIAIVSCTAVGYYTSHYVRPVYQATTKLMVYPNETSDKTVPDAGAINSSILLIKTFKQLIMTPRILDKVVADYPDLHTTKGELGAKIGITSVSETQIMTVVAADASYERAAKLANAVSKVFQQEVRTLMRLDNVSVLSWADPSDRRETASSGTTKNVMIAFVLSLMIGTGIAFLLDHIDDSVKAEHDVRVRLGMSLLADVPKIRRRDLAGPDDRDKTAYRARREKNVTLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CAM7</accession>
    <name>A0A398CAM7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_29550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00186">
        <property type="protein sequence ID" value="RIE00186"/>
        <property type="gene ID" value="D3H35_29550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="360" mass="40202" checksum="8EE55FF4A038ACFE" modified="2018-12-05" version="1">MLKTHAIKIQFRFEDIMAVTIIDVARRANVSKSTVSLVINNSPAIKLETKYKVLRAIEELGYVPNINARGLTSRKTNILGVLTMVENLSQKSYNFDSDTEIFSYDVSIGIPKGLVNTDFGLLNERFCIPENSNDLPLLIKNNRIDGLFIIGGLFGDDFAKKIKDCGIPTVVVGRKNEFFDYITADLEQGVFLSTTHLLETGHKKLCYINCPVTFSTSVDRYNGFQKAIDSSEVKPEEKWSINAEHNNGAGGYQAIKDIWEAGKRPDAILAANDSIALGIMRYLYEQKVRIPEDISMISYENSILSGYSVPALSTVDINKELIGEEACRILLNRIARPKSKRVSMVIPTTLVHRDSVIVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBC0</accession>
    <name>A0A398CBC0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_28995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00446">
        <property type="protein sequence ID" value="RIE00446"/>
        <property type="gene ID" value="D3H35_28995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="71"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="293" mass="33010" checksum="32A7DCD9D46B91B3" modified="2018-12-05" version="1">MKTNQMNQAIVHAAFIILAVFCLFPFLLLFMSSITDESAIVGNGYSIWPSDFSLEAYKYLWAQKAAMFHSYGITILITVVGTFFGLLISALLAYPLSRRDLPMRGILSFLVFFTLLFNGGLVPTYLIYTEVFDMKNTLMSLLIPGLLTNGFYILLIRTFFANSIPVQIIESAYIDGASEFKIFYRMVLPLSLPILATIGLMLTINYWNDWFNGLIYVTEPSLFSIQNLLNRMLVNIQFLQQNNLGGQQNLTANLPMNSVRMAMAVVGILPLILVYPFFQKYFVKGLTIGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCT5</accession>
    <name>A0A398CCT5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spore coat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_09100</name>
        <name evidence="4" type="ORF">D3H35_25290</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Spore coat</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CotF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000041">
        <property type="protein sequence ID" value="RIE00996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00996">
        <property type="protein sequence ID" value="RIE00996"/>
        <property type="gene ID" value="D3H35_25290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04090">
        <property type="protein sequence ID" value="RIE04090"/>
        <property type="gene ID" value="D3H35_09100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012851">
        <property type="entry name" value="Spore_coat_CotF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07875">
        <property type="entry name" value="Coat_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0946">Virion</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="125" mass="14425" checksum="2AF9C07F89499629" modified="2018-12-05" version="1">MYSQQQLPEADMAYTILSDLKRVTREYATAATESVCPQIRQTFTQLMDDTLKLQGELYYCMQQNNMYNASSPALRQEIDKQLNQYKQTQQKTNQFVQQSRSQPASISPGAIAQQQQQQPPAFQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD46</accession>
    <name>A0A398CD46_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_22070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01106">
        <property type="protein sequence ID" value="RIE01106"/>
        <property type="gene ID" value="D3H35_22070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="199"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="433" mass="48465" checksum="205EC52A64F2A2C0" modified="2018-12-05" version="1">MGRHSGRAAVLSALFMGLGQLYNRQWLKGILLALIELAFLIYLLPRAIKDAQGLITLGDTPQLFVDGIFIPGDHSIYMMVFGLITLLNVAIFIAVYAVGIMDARKVGQARDEGHSSNSFMKSLYVLTDKGFPYLMLTPSVALILFITLLPLVFGVLIAFTNYSSPNHLPPRALVDWVGFSNFADLFRLPSLSRTLGGVALWTFVWAILATGGSFLIGMLLALLTNASGIRFKKIWRVIFILPWAMPQFISALIMRNMLNQEFGPINRALDRLGIDPIPWLTDPTMAKISCILVDFWFEFPYYMILITGVLANINKDMYESASLEGAGTFTRFRAITLPMVLQVTFPLIIMGFAFNFNNFTFIYLLTGGEPRNISFSFAGHTDILLSWLYKITLEQNQFHLAATVSILIFLVISAISVVSLRSSKSYQEEDMMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDE7</accession>
    <name>A0A398CDE7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="8">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">folD</name>
        <name evidence="11" type="ORF">D3H35_26370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00723">
        <property type="protein sequence ID" value="RIE00723"/>
        <property type="gene ID" value="D3H35_26370"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4 8" id="KW-0521">NADP</keyword>
    <keyword evidence="1 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5 8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="9">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="10">
        <location>
            <begin position="123"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE00723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="285" mass="30368" checksum="DD91FEA168771164" modified="2018-12-05" version="1">MSAQIINGKQISETIRSEIRAEVDRLKEKGLRPGLVVILVGEDPASQVYVRNKAKACEDLGFYSEVVRIPADTTQDQLLALIDKYNADAAIHGILVQLPLPKHIHEKAVIDAIAVAKDVDGFHPISVGNLMIGDDALLPCTPSGCVELLKRTGNSPAGKHVVVIGRSNIVGKPVSMLLLRENATVTMCHSKTPNLPEMARQADILVVAVGVAKLVKHDWVKPGAVVIDVGMNRLPDGKLCGDVDYDDVADTASWITPVPGGVGPMTITMLMSNTLKAAKIASGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CET9</accession>
    <name>A0A398CET9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_24120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01686">
        <property type="protein sequence ID" value="RIE01686"/>
        <property type="gene ID" value="D3H35_24120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="323" mass="34447" checksum="FD6BBF3678853367" modified="2018-12-05" version="1">MLSPFVVYGLFLLCYGVNPVDLYVSMVKSTFGDLYGLGEVLLKATPFVLTGLAAALPAKAGLVNVGGEGQLAIGALFATWFGVFYLGEFPAWLGIPLMMIAGALGGAVWAGLVAVLKVKGRLNETITSVLLNYVATFTVGFFVHGLLKDPESFNWPFSPEISSSLRLPIVDGTRLHIGFVVALALAAIVWFVLSKTRLGFRIRVLGSNRLAAQRAGFNINKMYFWVLIAAGMLAGIAGMIEIAGIEGRLRASTGVNFGYLGFLAAMMAWNNPLRLIVTAFLLGMISVAGNTLEIGSGLPSSSVNILMALVLFFILGSGRWAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEY5</accession>
    <name>A0A398CEY5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_13150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01746">
        <property type="protein sequence ID" value="RIE01746"/>
        <property type="gene ID" value="D3H35_13150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039532">
        <property type="entry name" value="TetR_C_Firmicutes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14278">
        <property type="entry name" value="TetR_C_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="198" mass="22858" checksum="A8E7C21EA26CB42C" modified="2018-12-05" version="1">MSTASPRTDPRIIRTRQLIRDAFIDLLQEIELEKITVNRIAERATINRVTFYLHYRDIPDMLERIADDMVNEIQAILRDVPNQTRSDMDWSILVKILEHIADNSKFYKVLLASKRIPVFTDRLTKLIAEVITSRAEKREASLSVSAVSVPKDIAIWYGSSAFIGTIVCWLRNDMPYTPLFLAKQLSLLFRLYQNTADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEZ4</accession>
    <name>A0A398CEZ4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_22280</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. EmrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01140">
        <property type="protein sequence ID" value="RIE01140"/>
        <property type="gene ID" value="D3H35_22280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="10">
        <location>
            <begin position="11"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE01140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="521" mass="55545" checksum="905DADDD7885B418" modified="2018-12-05" version="1">MSGKQNKQGFVIAGLLLAILMASMDNSIMATAMGSIIGELGGFDKFVWATSAYMVAEMAGMPIFGKLSDMYGRKRFFIFGIVMFMLGSILCGTADSMVQLSVYRAVQGIGAGALLPIVFTIMFDAVPSDQRGKLSGLFGAVFGLSSIFGPLLGAYITDHIAWQWIFYINLPIGLVSTGMIALFYKESREHSKQQIDWAGAISLVGAIVCLIFAMELGGKQYAWDSVQIEGLFAGFVLLTAVFLYAEKRAKEPIISFQMFKNRLFATSNALALLSGAAFITASVYIPIFVQGVLGGTATNSGLILLPMMLGTVVTATMGGMLISKFSYRSIMIPPLFVLAAGFALLTTLTPDSSRLVITVYMIMIGLGIGASFSVLSNSVIHSFPLNQRGAANSTLGFLRSFGMMLGITVFGILQNHSMSRKLTEAFAGSDQASLARDLNLSDPHSLMNPATRAQIPPEALSRITNGLSSSILDAFAWSLVPALLALAVAFLMGKEKHEAEPSVASRSPRPEPALGGLEGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF47</accession>
    <name>A0A398CF47_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rplU</name>
        <name evidence="6" type="ORF">D3H35_27590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00512">
        <property type="protein sequence ID" value="RIE00512"/>
        <property type="gene ID" value="D3H35_27590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="103" mass="11335" checksum="FDF9421110A2ECBC" modified="2018-12-05" version="1">MYAIIETGGKQYKVQAGDVIFVEKLSANEGDSVTFDKVLFVSKEGGLTTGSPLVSGASVTGKVEQHVKGEKIIVYKYKPKKNYKRKQGHRQPYTKVTIEAIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF63</accession>
    <name>A0A398CF63_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Septum formation initiator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_23620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01363">
        <property type="protein sequence ID" value="RIE01363"/>
        <property type="gene ID" value="D3H35_23620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="106" mass="12066" checksum="AB66FE485D31E4C1" modified="2018-12-05" version="1">MSTRSAAAAPTYMGVRRRLRLLLFVVVLFMSWALYTYIAQHGQMSDRGQQLRETEKQLSDAKLKSDRLTQEVSRLNDPEYIGQIARKDQGMGMPGEQAIHVEPTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFL0</accession>
    <name>A0A398CFL0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Muramidase (Flagellum-specific)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_23175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01290">
        <property type="protein sequence ID" value="RIE01290"/>
        <property type="gene ID" value="D3H35_23175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002901">
        <property type="entry name" value="MGlyc_endo_b_GlcNAc-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01832">
        <property type="entry name" value="Glucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00047">
        <property type="entry name" value="LYZ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="LYZ2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="232" mass="26206" checksum="9EF3E78D856C70B3" modified="2018-12-05" version="1">MAKLSKSAFFAQLAPLAIRARREGSPLFPSTRLAQNLLETGCSINEHFNLGGFKIGSGKPNQWWKGRTYTTSTWEVVGGQRVQTTATWRSYDTVFDFYRDQDRLFQLARYARVRAARTPEEQCLALYQCGYATDAPANVDGDPAYYEKLIRIINENNLKKYDRTEEDEAMTDAEKKAFDALVARVAKLENRGPPPTWFVNEFGSADLGGVINDPRFTAEGWRTLAVAMRVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFW1</accession>
    <name>A0A398CFW1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_26750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00792">
        <property type="protein sequence ID" value="RIE00792"/>
        <property type="gene ID" value="D3H35_26750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="127" mass="13596" checksum="6A4869D7C1A048C5" modified="2018-12-05" version="1">MAVPTRFGASGRGARKRRSQRNRSDEGPGELSVALIAGKRELTVEVRDTGPGMDKAQAAKALEPFYTTKGGAGLSFGLGLPYAYQVMRKHGGSLHLRSKPGVGTSVYMTFPKRSVKAVWMEGGNRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFX0</accession>
    <name>A0A398CFX0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AEC family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_26810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00802">
        <property type="protein sequence ID" value="RIE00802"/>
        <property type="gene ID" value="D3H35_26810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="308" mass="33739" checksum="FF7DC4E08C39FDF3" modified="2018-12-05" version="1">MNILLHILMNNVLPLTVMIAVGMAMEKAFKMDIKTLSKLNFYVFSPAIMFNLLYRTDIPLKLFGQVMLFVLCFLAAQYAVLEAVVRIRQYDGGMRSAMRNSVLFYNSANYGIPLNQLAFAGNPYTLSVQILVMMTQSLIPNTYGVYNVNAHKAKWKDIRKVILSMPVIYVIPVALALRYFEVSVPGPIETPIGYLADAFIGTALLTLGVQLGGMKWRVSRSMAADVGISVFLRLVIGPALAALVVWALGIHGMMAAALIVSSAVPTSLSSVLLAVEFDNESEFASQTVFVSTVVSIVSVTTVIYLLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG04</accession>
    <name>A0A398CG04_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_23685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01375">
        <property type="protein sequence ID" value="RIE01375"/>
        <property type="gene ID" value="D3H35_23685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="13"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="222" mass="23957" checksum="7A8EE76BE4EF73F7" modified="2018-12-05" version="1">MKDDLIELLWEGLRETLYMVFWSSIFALTLGLALGIALVVTDKGSIRPFPAVHRLTGFFINVVRSMPYIILIVLLLPVARWIVGTTLGPTAAIVSLSIAAAPFLGRMIENSLKEVGGGKIEAAKSVGASSFAIVWRVLLPEALPALIRSMTIAVIAITEFTAVAGAIGAGGLGSLAIRFGYQRFREDILFATVFVILALVQTIQWSGNAAAKSIERKRFKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG39</accession>
    <name>A0A398CG39_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YafY family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_24625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01693">
        <property type="protein sequence ID" value="RIE01693"/>
        <property type="gene ID" value="D3H35_24625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="303" mass="35222" checksum="12EF93FE8F69667B" modified="2018-12-05" version="1">MEKVERLISIVMILLQKNIVSTTEFSKLFNVSKRTILRDMETLSYSNIPIYAINGVHGGYGIMDEYKLDKRLLSSKDLENILTALGGLGQILFSDEVELTIKKIDAMIGSTSWKGSIHLSFYDWEGRSEILQTLNTCQESIVKKKLVSFDYIDKDGITTNRIIEPYQLHFSEMSWYLKGFCLHRQSYRTFKLSRIDNLIMDEQTFIPRDYLLEQEHEASYQPQLVAIKALIPPSIKDQFIERYGRKSIESYSSEYLLATIHVPQNSTGFQFLASFGTNLEIVEPQTYVEEFRNYLNKMMEKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGM8</accession>
    <name>A0A398CGM8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Poly(ethylene terephthalate) hydrolase</fullName>
            <ecNumber evidence="5">3.1.1.101</ecNumber>
            <ecNumber evidence="2">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_14020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(ethylene terephthalate)(n) + H2O = (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12420"/>
            <dbReference type="Rhea" id="RHEA-COMP:12421"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:131701"/>
            <dbReference type="ChEBI" id="CHEBI:131704"/>
            <dbReference type="EC" id="3.1.1.101"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:49529"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a butanoate ester + H2O = an aliphatic alcohol + butanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47348"/>
            <dbReference type="ChEBI" id="CHEBI:2571"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:50477"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:47349"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.101" evidence="5"/>
    <dbReference type="EC" id="3.1.1.74" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01893">
        <property type="protein sequence ID" value="RIE01893"/>
        <property type="gene ID" value="D3H35_14020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041127">
        <property type="entry name" value="Chlorophyllase2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12740">
        <property type="entry name" value="Chlorophyllase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="766" mass="84123" checksum="4FDB64238D1E2AC7" modified="2018-12-05" version="1">MVDINRTELTETSRGQTRREKLRHKISGMYRYDYGLWRWASAGLWAVVMAVSAFSALGMPTGLGIAFDVGSAMALMTAAMALTAWLAALVLALVGLKLPRLATGCFLFAGALVSVALQYSEWDWRLSLVGAALLALAGAGAGALTGWAAARKIRWRQASIVLLACILLAAAIRYTSAVWPGKVSGDDDSDTVEVMALASAKKVEPLAADPSQPGTYSYRYFTYGSGDDERRSDFGEDVLMLSDSVDGSPYLKGWRWLRTLFWGFDAKELPVNGRVWMPEGEGPFPLVLMVHGNHLMEKFSDEGYGYLGELLASRGFIAVSVDENFLNYSVWSDVPKEDMKARAWMLLKHVGQIQSFSTQADSPFYNLVDFKRVALLGHSRGGQAAAMAADRGVWFPEDEGLPAIGSYEVQAVIALAPTDTTIGNNRSKLSDISYLTLQGAKDTDLVNFYGDRQYGRASFDAAHPERFKASLYIGDANHSRFNTEWGDYDNAIPASLFIRPEGVLAANEQRQIAKVYVSAFLEATLHGETSQRRLFQDYRAGLALLPDTRYFSRYEDGSFQAIARFEGDSVSDLGAGITAKSEGVSDWRHADAVDRQEQAKGNRGVRLEWEKGDASYEIRWDGVPSAFSEDGSLAFSLADLSESDAPLSIDVELTDESGTVARLPLASFMPLARPLPNADMTWFEGMDKYLSDGKFRNASEFVYQTYRLPLEEFSNAAPDFRTDRWKSVTFRFHGGPAAIMLDDVGYAPSREEQLIAATSATGAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGN4</accession>
    <name>A0A398CGN4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_12865</name>
        <name evidence="2" type="ORF">D3H35_25170</name>
        <name evidence="3" type="ORF">D3H35_25195</name>
        <name evidence="4" type="ORF">D3H35_25215</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01633">
        <property type="protein sequence ID" value="RIE01633"/>
        <property type="gene ID" value="D3H35_25170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01638">
        <property type="protein sequence ID" value="RIE01638"/>
        <property type="gene ID" value="D3H35_25195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01640">
        <property type="protein sequence ID" value="RIE01640"/>
        <property type="gene ID" value="D3H35_25215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01699">
        <property type="protein sequence ID" value="RIE01699"/>
        <property type="gene ID" value="D3H35_12865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="143" mass="16574" checksum="514B35A70F2D14A3" modified="2018-12-05" version="1">MEVMFNEFCISNDKTRIDKDIVIDFLSRSYWANKRPIDRTIKAIENSYCLGVYKDEKQVGFARVISDGATFFYICDVFVLEEYRGKGIGKKLVEIIVDSDEFEGMMGLLGTLDAHGLYEKYGFIKDPDRFLKRPPTWSVQQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGX7</accession>
    <name>A0A398CGX7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01720">
        <property type="protein sequence ID" value="RIE01720"/>
        <property type="gene ID" value="D3H35_12990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="123" mass="13072" checksum="5089144419B51E93" modified="2018-12-05" version="1">MTLNNGTPSHSFGEFVVLTLNNGTPSHSFGVFVVLTLNNGTPSHSFGEFVVLTLNNGTTSHSFGEFVVLTLNNGTPSHSFGEFVVLTLNNGTPSHSFGEFVVLTLNNGTPSHSFGQFVVLTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGY4</accession>
    <name>A0A398CGY4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4177 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02466">
        <property type="protein sequence ID" value="RIE02466"/>
        <property type="gene ID" value="D3H35_17355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025234">
        <property type="entry name" value="DUF4177"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13783">
        <property type="entry name" value="DUF4177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="64" mass="7402" checksum="65A029BD8F0958E3" modified="2018-12-05" version="1">MYEYTFVETSLGGFFTKATHQETILEYAKAGWRLVQVLPTNYNGHGKPTSYEIIFERAVKEKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGZ3</accession>
    <name>A0A398CGZ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydrodipicolinate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_28405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00349">
        <property type="protein sequence ID" value="RIE00349"/>
        <property type="gene ID" value="D3H35_28405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="352" mass="38709" checksum="07DD711C4D838A1A" modified="2018-12-05" version="1">MAAAALSTVKKEILFQGTVIPAHPLALKADRTLDERRQRALSRYYLASGAGGIAVGVHTTQFEIREHGLLETVLRLAAEEVELSGRSDEILKVAGICGPTEQAVAEAELAVSLGYDIGLLSTGGLRDWSEESLIERARAVAAVIPVFGFYLQPSVGGRPLSFDFWRQLADIPGVVGIKMAPFNRYQTIDVMRAVANSSRRGEIALYTGNDDNIVADLLTPYRFQVDGEPMELRIVGGLLGHWAVWTRQAVKLLEEIKAVRATGTIPPELLTRNIEVTDTNAVFFDTANGFAGCIPGIHEVLRRQGLLDGIWCLNPEETLSPLQAEEIERVYREYPHLHDDAFVSEHLAQWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGZ9</accession>
    <name>A0A398CGZ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01735">
        <property type="protein sequence ID" value="RIE01735"/>
        <property type="gene ID" value="D3H35_13075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="160" mass="18041" checksum="B2B793AA5B26FD04" modified="2018-12-05" version="1">MPSNRPEQPTEQQEKLTMSMRGLGTRTVLYQQSVAASLGLHNNDFLSIDILHEKGPVTAGELSRLTGLTTGSVTSLIDRLEKNGFVRRQQDPHDRRKVIIVPLYEDKEDVSATYLQLHSEMVKLASSYSDEELELITQFLNKAGSVLEEQIHHLNSKAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH04</accession>
    <name>A0A398CH04_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_22890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01242">
        <property type="protein sequence ID" value="RIE01242"/>
        <property type="gene ID" value="D3H35_22890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="298" mass="33191" checksum="ED481CCFBE005D1B" modified="2018-12-05" version="1">MDSLKHMNAALAYIEARLTDDIDMAEASRIALCSEYHFIRMFSFLAGIPLSEYVRRRRLTRAAAELRQSDTKVIDLALKYGYSSPDAFARAFQQLHGATPSEARRPGAMLKAYPPMAFRLTIQGGSEMNYRIVDKAAFRIVGYSKRVPIVFNGVNPDIAAMWNSLDEEEFARLERLSDVEPAGLVSASANFSEGPIEKQGEFDYYIGAATTNVCPERFAALEVAATTWALFEAVGPFPAALHSVWERIYSEWFPTSGYELAPGPEMLRNVSKDTSSPEFQSEIWIPVKKRASGSEASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH42</accession>
    <name>A0A398CH42_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00228">
        <property type="protein sequence ID" value="RIE00228"/>
        <property type="gene ID" value="D3H35_29785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipase_3" evidence="1">
        <location>
            <begin position="69"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="889" mass="99048" checksum="88456520295DD4C1" modified="2018-12-05" version="1">MSEPIIQGDYAPYFLAQCSLRAYDPPAVLQAVYSGSESPWTFKEDYFFDIPATDTQGFIIFSKETQEVVIAFRGSYEWIDWLRDLKNLAYSPWNGTKVGVGFLAAWQSASNSITVRLDRLVKELGPMMDLSIYITGHSLGAALATLSIVDLWQGRFSTKPPKKLAVYTYGSPVVGNRAFASYYKTLGAHFQSNHYLDPNDQIEWFNNFATKSFFQGDDPFCKVDGQIRLPAANGHRIANYIDLLEPSAPTRRRALGVPAADFERDPNKLVSYIVLRTFTSDNYEAATTDKVSFFIGLDDSGAGGFEFNLDRPVNNLVPFRAGQSDTFVLELPLGNGLLLNGFRNCKLEKTKGGSDWDLLGLQILVDGSELFNDMNISATFTDDNPDFLFPIELAPFAVPAGIIAVGERPYCFVIGKDGHLWCNWWDGYEWVWSDHGRPDGTTVLLPFGVVKTGDERPYVFVQCSDGNLYFNWWHGAASKWQWTLHPSPSDFSGKIAGPIGAVSVQSSPLYLVHNNGQAFVHYWNGSDWAWSNQRIPGGKLAAAGIGACVVDDYRAYGFFNCSDGMVLSNYMTGSSMSEWVWYDQNKPAALTIASSIGAVGIDNRPYYFVVSADGEVWSNWWDSGQSRWEWTSQNVPAGIKATEGSGLLGIRNLPSYFVLCDDGNLWLNGWNGSAWFWSNQQKPPGRTIVKGAGAVEVGDNPYCFVLCDDGSLWVNGLNGQQWSWTNHKEPGTPNELFNLEVNIELVTCVQPQENGSFGIYDEVYLTKNGVKAWPVDQPYLSMTKGQFSDVKQKFEVVRGAAVVWELWDKDDITSDDDLVEFAFSFDTAAYDQQEDRKVALKDCSPGKSYRINGRNIEDGVYGYYLTVQVKRISQTSSTQGSGVTSAFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHE1</accession>
    <name>A0A398CHE1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)H-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_14055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nitroreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01900">
        <property type="protein sequence ID" value="RIE01900"/>
        <property type="gene ID" value="D3H35_14055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02149">
        <property type="entry name" value="NfsB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033878">
        <property type="entry name" value="NfsB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="221" mass="25175" checksum="55AE92CD7E9C8B94" modified="2018-12-05" version="1">MSITKEEVLNAFRFRHACKEFDSARKIPDYEFAFILETGRLSPSSYGFEPWQLVVLQDPVIREKLRANTWGAQKTLPTASHFVLLLARTQEALTPESDHIQHIIRDVQQLPPENAAGKTSVYRKFLETDFGLLGSERAVWDWAGKQAYIALGNMMTAAAMIGIDSCPIEGFEHVPVERVLQEEGIADGERLRLVSMVAFGYRVREPRSKTRRPIEEIVTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHY1</accession>
    <name>A0A398CHY1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c biogenesis protein CcdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_26515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00749">
        <property type="protein sequence ID" value="RIE00749"/>
        <property type="gene ID" value="D3H35_26515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="9"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="236" mass="26165" checksum="FAC1DCEC8480C590" modified="2018-12-05" version="1">MADLNVGIAFAAGFASFISPCCLPLYPSYLSYITGISVSQIKTDTSAQVRLKTMSHTFFFILGFSSVFFSLAYAANAFAEWFRDYQDTIRMVSAILIMLMGLFLMGIFQPQTLMKERKMKMKIRPAGYVNSFIFGVGFSAGWSPCVGPILSAIIGLAASNPGTWAGLTTAYSVGFAIPFFVLAFFLSSTRWILKYSNLMMKIGGALMIVMGILLFTDRMIDITIYLQSITPEWLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI79</accession>
    <name>A0A398CI79_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2207 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_13060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01732">
        <property type="protein sequence ID" value="RIE01732"/>
        <property type="gene ID" value="D3H35_13060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018702">
        <property type="entry name" value="DUF2207_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09972">
        <property type="entry name" value="DUF2207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017413197" evidence="3">
        <location>
            <begin position="28"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="580" mass="65441" checksum="523339CE26E3D0E4" modified="2018-12-05" version="1">MPMTKVSKVVGLLFSLFLLLAAQPAYAEEHSFEISEVDIDARIDGDGNMHVAEVDKYRFDGAFNGIIVDLNTSGSDGIDHFQAFEVTEEQNIPLRFEEASVDDNKVQYKIYAQSADETKLFRFTYSIKNVVQVYADTAELYWKFFDQTNPSKLGSVNIDVELPDGADPEEITAFGHGPLHGAVKIDNNGVVRYQVSPLPAEKMLEVRILFPGSYVPGSAKIDAASKLDQILEEERNWSADTDSADGADDASVYGALALLIANLAAGTILYIKFGKPLRPDWKGKYYRELPADVTPAVVSYLMKYRIKPRDLMATMADLVRKKHVDMKMIKGGGGWRDKTDYTFRLINKRTDELQPHETMLIDWFFGELGSSGQVSLSSIRRQAKTGAAAFLKRWSQWQAEVVKAVDQLDYISFRKWIPRFVILAVVVQFFGFWFLAPEDWRWLMFCSIPLLFFKPKRKRRTKLGQTEFTKWKAFKRFLHDYSQIASREPMAVHLWEHYFVYAIPLGEAKKMIAITRLNVPNADHDHTYFDNSIFYHYDHWAGSFDRTMATAHKSANSGDSDGSFSSGGGGGGGGGGRGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIH9</accession>
    <name>A0A398CIH9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_15730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02190">
        <property type="protein sequence ID" value="RIE02190"/>
        <property type="gene ID" value="D3H35_15730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="298" mass="34485" checksum="E1203A358D423F75" modified="2018-12-05" version="1">MQDKKRTILEAAIRCFSRKGFHATSIQEIAREIGMAKGSMYFYFNSKDELYLSVLEYYTDMLFRCMEELPEDRELSSRDKLRVLIERQFRFFREHLHFMRMLFLEPATGLNPQVQNLLMRTRARSAVWTLSHISAIYGNRAARYVTDAATMFEGMTGRYLEKLFFDDAELDEGRVSRFLINRIDHLMKGLLLTGEEPILPAPDMNALREKAGWPLEAEAQQRNGQLEELKRLVSAIPDSVPPAVRTEAASALERLESEWAKLVPDKLLAKGMLALLREYAAVYSWTEWESLLDGLESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ95</accession>
    <name>A0A398CJ95_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02415">
        <property type="protein sequence ID" value="RIE02415"/>
        <property type="gene ID" value="D3H35_17055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="208" mass="22992" checksum="1FF26FF47C8366C9" modified="2018-12-05" version="1">MNNTVYLYVFDTMSDWEIGYLAAELNSGRYFRQGLAPAKIVTVGIEKTPVTTMGGLKIMPDIKVDECSIKSVDALILPGGNTWTEAIHVPILKMAERCLKEGIVVGAICGATLGLAQAGLLDSHWHTSNDLAYLKMVCPSYTGEEYYNIESAVTDERLITASGVAPLEFSVHVLKALDVFSPKTLDAWYRLNKTHEPKYFHELMSSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJB0</accession>
    <name>A0A398CJB0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02435">
        <property type="protein sequence ID" value="RIE02435"/>
        <property type="gene ID" value="D3H35_17170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="451" mass="46601" checksum="5E565AEF7ED12D1C" modified="2018-12-05" version="1">MGFEDADNSYDKIVLDTLSRLSLNTPLTDVNPGSIVRTLVEAVSWEVSAAYAKMSAIYDMGFLDTATGDALDRLASLFGIKRADGPEITGQTLFTRDVQVTSDVSIPAGTLLTKIKASNRKQVKYRTSASSVLKTGQQTVTVPIVADLGTDSGSASSSDSLSALQDNELTADDVGNGTDQNIMQLASPLPGIRQAQLLFPTSVRKQRESDDELRARIQGAINKAGGGTEGAIREAVLATGLARNVAFGPAPGAPAPEPGTLLVSVDADMSNPTTAAAIMDAINLSKAAGILIQVQQVAKQKVALQFQVTPTDETADESSLDRVYLHAAQAAQQAIQANEPGQPLLWNRIAANVLKVPGVLDVKGGLSPVQSPSAAGSALLAAAAAGTGASPAESSVLDRLDMQQPAQSAQLTTVKVQGPSNAELNFDVDDSGQLVYRAAGTPSGPEGGATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJB1</accession>
    <name>A0A398CJB1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_17030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02410">
        <property type="protein sequence ID" value="RIE02410"/>
        <property type="gene ID" value="D3H35_17030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="140"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="240" mass="28007" checksum="E3CA6694817DC846" modified="2018-12-05" version="1">MLVEDETIIRQGLKTFIEDMIQGFRVIGEENNGRDALLFLQREIPHLIVTDIRMPEMGGIEFIRRVRDQLPHIPIVILSGYDEFSYARDALRFGAIDYLLKPINRVEFLKCLKKIEAAYLAEKVQDSEKAFVNESNPVIQRIKKIIEQNLEKELSLQYVSEQVHMNYNYLSSLFRSETGISFSDYLMEARIEKAKTTLKNTNLKVYEIAEMCGYTSPKHFMSVFRKKIGCTPSEYRERCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJC1</accession>
    <name>A0A398CJC1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_17080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02420">
        <property type="protein sequence ID" value="RIE02420"/>
        <property type="gene ID" value="D3H35_17080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017389343" evidence="2">
        <location>
            <begin position="29"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="451" mass="49517" checksum="2D4006BF3D51B784" modified="2018-12-05" version="1">MKRKWTALMIALLTTFVVACGNNGDSNAGEQTPVSSGSEASKELKGEIVLWHSFTQGPRNDFMKQAADDFMAAHPGVKITIETFAWSEFYTKWTTGLLAGQVPDISTALPNHVVEMLDADAIVPLDDVIDHVGRDRFYEAPLKEGTLDGKAYSIPLYSHAQVMWYRKDLLEKAGLQVPKTWAELKEAAVKLNSPPNVYGLSVPMGNGDMLATRFLNFYVRSAGETLITKDGKANLTSQAAIDGIKYWTDLYKSVSPNGSINFKTLDQSTLFYQGKTAFDFNSGFHIGGVETNSPALLDQIGAAPIPKINADDPDRGIETSNIPMVVWKKSKHPEIAKAFLESLYEKERYIKFLHSVPAGMLPAMKDIAEDPAFLDNPTIKKFNDAVKVISDAVDKGTAIGMENGPTLQAGIITSQSVIETMFQDIVLKNEKVEDAAARAEKQLNELFQTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJH1</accession>
    <name>A0A398CJH1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_16280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02282">
        <property type="protein sequence ID" value="RIE02282"/>
        <property type="gene ID" value="D3H35_16280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="257" mass="28668" checksum="69CE7557B0AAA31B" modified="2018-12-05" version="1">MTDAGELVVRSLNKSFVRDGDELRVLSGIEFKVKPGEFVSLIGPSGCGKSTLLKIVAGLDLDHQGTVHLSGKPVDRPSRDKGFIFQEHRLFPWLNVENNIAADLRLKDPEVRKRVDEMIALVKLTGFEKAYPRELSGGMSQRVAIARALVRDPGVLLLDEPFGALDAFTRHHMQEALLDIWQKNGTTMLLVTHDIDEAVYLSDRIIVMDARPGSVKEIVPIDLPHPRNRVGPAFQELRAKVLSVLERSLPVKDDWAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJZ4</accession>
    <name>A0A398CJZ4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Recombinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01509">
        <property type="protein sequence ID" value="RIE01509"/>
        <property type="gene ID" value="D3H35_24455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="1">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="137" mass="15315" checksum="D166D03BF0AB3CE8" modified="2018-12-05" version="1">MNNPKRVALYIRSNQSNKNIADQVNPLAQACVDQGKCLVQIYMDRGISGLCLNPPSLLRMLEDAENGLFEEVMVHNLSRLSRRSIDVLTITKKLRAASVDLTVPDSRLDLNSASGRFAFQMMEATVELELYLQEGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJZ7</accession>
    <name>A0A398CJZ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02462">
        <property type="protein sequence ID" value="RIE02462"/>
        <property type="gene ID" value="D3H35_17335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037891">
        <property type="entry name" value="Cdil-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160207">
        <property type="entry name" value="SSF160207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="147" mass="17078" checksum="E8C4A7212F8FE180" modified="2018-12-05" version="1">MEELYTIYVYKDKKDTLLVIPYAKNDQGVRTNVNKPQIIEPPLIMEQLGLKTREAFEVAIQETYLKRDHVYVIAHLTGIKSWKKLHKEYLFVRAILTPDSQYIFYPGIGVTSDWDEEKGISLPTNATNEEMGTAVMNTFELHRLSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK28</accession>
    <name>A0A398CK28_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C</fullName>
            <shortName evidence="6">Asp/Glu-ADT subunit C</shortName>
            <ecNumber evidence="6">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">gatC</name>
        <name evidence="7" type="ORF">D3H35_18450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 6">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the GatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02660">
        <property type="protein sequence ID" value="RIE02660"/>
        <property type="gene ID" value="D3H35_18450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="PTHR15004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="95" mass="10500" checksum="6759AF61497A1A21" modified="2018-12-05" version="1">MSITVKDVEHVANLARLELSDSEKEQFAGQLNAILKYAEKLNELDTEGVEPTSHVLPLANVMREDVAAPSWPIEKVMANAPEEEEGQFKVPAVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKN9</accession>
    <name>A0A398CKN9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="1 2">2.7.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">APS kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATP adenosine-5'-phosphosulfate 3'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenosine-5'-phosphosulfate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">cysC</name>
        <name evidence="3" type="ORF">D3H35_13280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the APS kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="1 2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01769">
        <property type="protein sequence ID" value="RIE01769"/>
        <property type="gene ID" value="D3H35_13280"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Phosphoserine intermediate" evidence="1">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="202" mass="22711" checksum="A65FBE394D633026" modified="2018-12-05" version="1">MKAEQLTWSSPIVTQADRERQNGHRGLVLWFTGLSGAGKSTLAVECERYLHRQGIRTYVLDGDNIRHGLNSDLSFTDADRKENIRRIGEVAKLMADAGLVTIVSFISPFRADRDIVRHSLGEGRFLEIYVRCPLAVCERRDPKGLYQKARAGSLTSFTGIDAPYEEPLQPELAINTDQVDVEQAVRRIIQYLDLHESLKADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKP5</accession>
    <name>A0A398CKP5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_18915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02722">
        <property type="protein sequence ID" value="RIE02722"/>
        <property type="gene ID" value="D3H35_18915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017403895" evidence="2">
        <location>
            <begin position="32"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="239" mass="26028" checksum="04E80A5A003C72B7" modified="2018-12-05" version="1">MKIKKTALLSAALITALSLSACSSNKTNNQAPSAITPTADAAQTAGNAEEEGLIPEPGAKLIIWEGKDEKPFIDAIAQEFTAKYKIPVEFQEVPATDQRKKLKTDGPAGLGADVLVMPHNTLGDAVASGILLPNDIFAEDTKANYPKELVDAVSLDGVIYGYPRNVETYLLYYNKELVKEEDLASWDSIIKFAKGYNDVGNNKFGFMWQVGDFYYNYSWIAGNGGYVFGQTARILRISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKW0</accession>
    <name>A0A398CKW0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02940">
        <property type="protein sequence ID" value="RIE02940"/>
        <property type="gene ID" value="D3H35_20250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017195591" evidence="1">
        <location>
            <begin position="36"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="368" mass="40637" checksum="8A9227B0D65F791A" modified="2018-12-05" version="1">MIRFSALAKKATTLLLGLSLLTGMLQGLTARKAEAAGTYEDRFVYMAKIMNNGTSVSWGGDENFVSALSSYNMWPVFAQQRSNPSNFPGIWGKSSESDDIEDYPNGGGVYTTDGHFWGVIQVSRIPALKALAEGGHAKFRIKTHLNSTTDNGAYIWAYANNSYSYTEFDYDETYDSNYNSAGSAKRWEAISRSTDPDKTVDSGWKSFDADDYIVIQTETHGAGTQVEDIVLSFGDFTSPSITNYTFTSDGTERENAAGQQQLFLKKNESIHLQYNFSEPVRATGLAPANIYDKHLLYTVPGGNGLPTDGQPQGMSLPKGSMTIQSNTIRPIRAHSNILRIFPIHTRPRIITIPATFLLRTAENWNPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL45</accession>
    <name>A0A398CL45_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03125">
        <property type="protein sequence ID" value="RIE03125"/>
        <property type="gene ID" value="D3H35_13470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="245" mass="27685" checksum="0C2B57DD72F4C217" modified="2018-12-05" version="1">MMEYRVDFLLGVFSVFFIQGTSILFVSIVFDQIDSLHGWTYHQIMFIYAVALLGRSLEHIFFDNLWTIGFQYIRPGNFDRLLIRPVNVLFQLIAERVQQDGVGNLLIGLIVMFTAAPHVGIDWGFADILLLLLMIVSSSAIFLAVNLFLASFSFWMVDSLPIMVAVHGSSDFARYPMSIYGKGIRFVLTWIIPYGFTAFYPAAVFLDPDGFRQFAVISPIVAVVSLTIAYFVWNRGLRAFSSTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLI3</accession>
    <name>A0A398CLI3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acylneuraminate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02069">
        <property type="protein sequence ID" value="RIE02069"/>
        <property type="gene ID" value="D3H35_15000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003329">
        <property type="entry name" value="Cytidylyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02348">
        <property type="entry name" value="CTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="240" mass="27143" checksum="A06C564FC669798E" modified="2018-12-05" version="1">MNNVIIIQARMGSTRLPGKVLKTLADKTVLAHVIDRVKCVKEVTEIVIATTAGLQDDPIASEAKRLGVNLYRGSETDVLSRYYEAAAEARADTVIRITSDCPLIDPEVSSRVLQAYAAGEPCDYASNTLERTFPRGLDTEVFSFESLAIAHNEAQTSHDREHVTPYLYSNKDRFRCRSVVSDEGIPDYRWTLDTPEDWELIRRLYEALYEPGRLFTWRDAAELMSLNSDWASINSHIQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLM4</accession>
    <name>A0A398CLM4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Stage III sporulation protein AB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">spoIIIAB</name>
        <name evidence="1" type="ORF">D3H35_26440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00737">
        <property type="protein sequence ID" value="RIE00737"/>
        <property type="gene ID" value="D3H35_26440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014198">
        <property type="entry name" value="Spore_III_AB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09548">
        <property type="entry name" value="Spore_III_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021435">
        <property type="entry name" value="SpoIIIAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02833">
        <property type="entry name" value="spore_III_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="172" mass="18736" checksum="5A2C76B5A546EF41" modified="2018-12-05" version="1">MIKLIGAALVLFAGTMIGYLQAARFAARPRQIRQLTHALQRLETEIGYGQTPLPEALKRMAHLLGPPLTGIFDRIADELAGGAGNTVRESWEAAINAGWSSTAMKSAERDALLRLGATLGASGREDQLKHVRLAMLQLQTEETTAREEQQRYEKLSRSLGMLGAALVVILMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLQ0</accession>
    <name>A0A398CLQ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide excision repair endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01788">
        <property type="protein sequence ID" value="RIE01788"/>
        <property type="gene ID" value="D3H35_13380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="36"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="118" mass="14003" checksum="C682F0E56DE503F1" modified="2018-12-05" version="1">MIIVTIPTPNVTITKQENPQESHIYGFTEFHLIPRDVGGIFMFYNKDEELLFVGKARKLRPRIKKHFEDSVSVIKAHRDEVAKIEVCVIENPVYREIYETFIINDRKAKYNEDKVFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM31</accession>
    <name>A0A398CM31_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ACP S-malonyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_07420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04406">
        <property type="protein sequence ID" value="RIE04406"/>
        <property type="gene ID" value="D3H35_07420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="3">
        <location>
            <begin position="7"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="416" mass="46252" checksum="3176AC121B8DA807" modified="2018-12-05" version="1">MEKIAFLFPGQGAQYRGMFKTHWVRYPEVRQTFEEASDTLGLDLFSLCSEGTEEELTRPQNTQPALLTAGVAAYRAWTRETGVVPFALAGHSLGEYTALVCSGAIPFNETLAIVRQRGWLMKEAASAGKGGMLAVNGMTGPEAEALLSELPEFDGQLAVACYNSSRQQVLSGPEAAMMEVERKLTARGMKTIPLKVGAAFHGPSMADAARQLETFLRERAASIGTPRQPVVSNATALPYEEGAESIIRGLVLEMTEPVLWKQTMEYLRNQAMEAAIDFGPQRTMKHLLLQDDPAAVVYAFDFPEDHEKLFSPEWKARRRSRSNRRLLEACLVAAVATPNRNEDRMEYTEGAVKPYREIEELLRESERRGAEPTDDDVRAALELLTVILRTKRASEQEQLERTNAIAFEIHRKAGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMB6</accession>
    <name>A0A398CMB6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable manganese-dependent inorganic pyrophosphatase</fullName>
            <ecNumber evidence="8">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="8">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ppaC</name>
        <name evidence="10" type="ORF">D3H35_12065</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PPase class C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03402">
        <property type="protein sequence ID" value="RIE03402"/>
        <property type="gene ID" value="D3H35_12065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00207">
        <property type="entry name" value="PPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022934">
        <property type="entry name" value="Mn-dep_inorganic_PyrPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA2" evidence="9">
        <location>
            <begin position="181"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="310" mass="33380" checksum="F2609D86EBCFF150" modified="2018-12-05" version="1">MEKFLIFGHKNPDTDTITSAIAYAELKSKLGFDAEAVRLGEVNGETQFALDKFGFDAPRLVETAANEVKSVILVDHNERQQSISDIDQVRVAEVIDHHRIANFETKGPLYFRAEPVGCTATILLKLYKENGVAVRKETAGLMLSAIISDSLLFKSPTCTPEDVAAAKELAEIAGVNAEEYGLAMLKAGADLSDKTIAQLISLDAKEFSMGSAKVEIAQVNAVDVNDVLSKQAELEAALNAIIEEKGLDLFLFVVTDILNNDSVGLALGKSAHAVEKAYNVSLENNKAVLKGVVSRKSQIVPVLTETFGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMD5</accession>
    <name>A0A398CMD5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_12135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03410">
        <property type="protein sequence ID" value="RIE03410"/>
        <property type="gene ID" value="D3H35_12135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="193" mass="21739" checksum="5559B949D1DD3AA9" modified="2018-12-05" version="1">MLNATLSLIATDGIEQVTIRKIAALAGSNVALINYYFGSKEKLIGEAIKVQFDSFREAFSALENREVDSLTRLKSFLLQILSSLQEHPELMKRLVGQGQESMSESQAEYVSFFKTKGFEQIRATLEEITGETNAKVTSAMMQQIFAAIFSPAFRSACARKQAGADDDREFLTNVSVEEQVDLFFNHYFYRYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMH2</accession>
    <name>A0A398CMH2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3886 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03450">
        <property type="protein sequence ID" value="RIE03450"/>
        <property type="gene ID" value="D3H35_12385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024980">
        <property type="entry name" value="DUF3886"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13025">
        <property type="entry name" value="DUF3886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="85" mass="9916" checksum="BBDC4B49BFF6E4AC" modified="2018-12-05" version="1">MSSKNRRSQPVKAEASDKPATLKDLLSADTLAKLKAHTDQMKQEQLQQAEQKRKKEEEARKEEQKRNENDFAYLLNHSKVKTTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMQ0</accession>
    <name>A0A398CMQ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01177">
        <property type="protein sequence ID" value="RIE01177"/>
        <property type="gene ID" value="D3H35_22515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="105" mass="11936" checksum="BACD9AF2A2E2CFF4" modified="2018-12-05" version="1">MSLPNRAQQELTPIYQCDSHLHHTLRSARDHLHQLCAHHANRLVRAETMDGDVFEGHILHSDRGIVYLSLSNESYARAFFPPPLNPTANFVLPLVLFNLLTISLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMS1</accession>
    <name>A0A398CMS1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Indole-3-glycerol phosphate synthase</fullName>
            <shortName evidence="11">IGPS</shortName>
            <ecNumber evidence="4 11">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">trpC</name>
        <name evidence="13" type="ORF">D3H35_03975</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TrpC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="4 11"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04656">
        <property type="protein sequence ID" value="RIE04656"/>
        <property type="gene ID" value="D3H35_03975"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="12">
        <location>
            <begin position="3"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE04656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="275" mass="29907" checksum="69B1D1EA2DAD8AC9" modified="2018-12-05" version="1">MFLDAIVATKREEVAALSRSMNIGTAERQIADMQPCRGFERAISQRLRPVGLIAEVKKASPSKGLIRPDFHPVSLARAYEAAGTDCISVLTDVDYFQGSNDYLKAIREEVAVPLLRKDFTIDERQIYEARLIGADAILLIAAILTKEQLSSFYTLARDIGLDVLVEVHDRPELETVLDIGKATLVGVNNRDLRTFVTDLRVTEQLIGLMPKGVTAVSESAISTPDDVAFVRGAGAQAVLVGEHFMRQSDVASAVEELLGPVDRSQEGAAQEGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMS4</accession>
    <name>A0A398CMS4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_25900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000043">
        <property type="protein sequence ID" value="RIE00891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00891">
        <property type="protein sequence ID" value="RIE00891"/>
        <property type="gene ID" value="D3H35_25900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017180288" evidence="2">
        <location>
            <begin position="30"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="207" mass="22933" checksum="EB85265BF782FB39" modified="2018-12-05" version="1">MRKKLLVVTVLMSLIVGVVFSSFAGTAEAEETVGTETGTGSQQAPIPQPTIPESPITEVRENVAVESTSVKIIKVEQLEGYLSFGDVLTIRKQNSSEFAYNYMSDRDDHQWKVPVQDVDRSAIYDVVMATTFIEIDTGKIFLYYDKKVITGEQLLSMNAWLLKVSGKVKVSFDFGSLSEYNNSTKFYVGDGANDSQLEKVQGATLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMZ2</accession>
    <name>A0A398CMZ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01277">
        <property type="protein sequence ID" value="RIE01277"/>
        <property type="gene ID" value="D3H35_23095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017307609" evidence="1">
        <location>
            <begin position="22"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="261" mass="29055" checksum="B8E290A8117AA0B8" modified="2018-12-05" version="1">MKKVVLLALVMMFSAVSVASAGGIHFVRASLYGQGYVGSNGFLTIPASYSANNVNQTHPEFFYGMYRDTHTCSTPCGPGLDIGILYKNGTWKFFSNLNSAAYTQTPINQAWDDGQTISLSPGQTIQMQVLLVQNANGTYKAELVVWNNSGTWLGTYSRQVNTAWAVAWKQDGKVNREQSLASNQAAGVPYLTDGSYFYDSVWGKGWLIHQNGTWYAWNDSKTYSALFKEDGTTQPPLSKYYYYTKTTDGTFVYDRVGIHYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMZ3</accession>
    <name>A0A398CMZ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small, acid-soluble spore protein, H family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_09850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Spore core</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SspH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03845">
        <property type="protein sequence ID" value="RIE03845"/>
        <property type="gene ID" value="D3H35_09850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042601">
        <property type="term" value="C:endospore-forming forespore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030436">
        <property type="term" value="P:asexual sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012610">
        <property type="entry name" value="SASP_SspH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08141">
        <property type="entry name" value="SspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="63" mass="7002" checksum="5CCF3D5FCD2DD66D" modified="2018-12-05" version="1">MKAERAREIYESESTYPVQLDDGQPVWIENVDVANGVATVQVGAKPTNTQTVAVERLQEGRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN00</accession>
    <name>A0A398CN00_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Potassium-transporting ATPase potassium-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP phosphohydrolase [potassium-transporting] A chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-binding and translocating subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-translocating ATPase A chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">kdpA</name>
        <name evidence="10" type="ORF">D3H35_15590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KdpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02168">
        <property type="protein sequence ID" value="RIE02168"/>
        <property type="gene ID" value="D3H35_15590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00275">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004623">
        <property type="entry name" value="KdpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607">
        <property type="entry name" value="PTHR30607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03814">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001294">
        <property type="entry name" value="K_ATPaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00680">
        <property type="entry name" value="kdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 9" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="526"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE02168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="559" mass="60118" checksum="D2D38122CA1ABBCB" modified="2018-12-05" version="1">MGILQIVVVLAVLVLLVKPVGTYVYHVFSNEPNRLDRIFGPFERLVYALIGLKNRVGMSWKKYAFSFLLTNIVLVAVGYLILRAQGVLMFNPNGVGEMEATLSFNTIISFITNTNLQHYSGESGLTYFSQMAVITMMMFTSAATGFSVAIAFVRGLTSKGRTIGNFFEDFVKAHTRIFLPAAVLVTLLLVALQVPQTLSATLSVTTLEGVAQQIAIGPVASLESIKHLGTNGGGFFGVNSAHPFENPNGLTNVVEILSMWALPAALPYTFGLFAKNRKQGWVIFGAMMSLFVLFLSLTYFSELRGNPAVNAMGIDASQGSMEGKEVRFGIPQSALFTTVTTAATTGSVNNMHDALTPLGGLAPLAEMMLNCVFGGKGVGLVNMLMYAILGVFICGLMVGRTPEFLGRKIEPREMKLIAIAILAHPFIILVPTAIAFLTDLGKGSISNPGYHGLSQVLYEYTSSAANNGSGFEGLADNTSFWNITTGLVMLLGRYISMIAMLAVAGSLVRKQWVPETAGTFRTDNKLFYGILIGTVLLIGALTFLPALVLGPIAEHLTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN28</accession>
    <name>A0A398CN28_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04756">
        <property type="protein sequence ID" value="RIE04756"/>
        <property type="gene ID" value="D3H35_04555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025681">
        <property type="entry name" value="COOH-NH2_lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14395">
        <property type="entry name" value="COOH-NH2_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="295" mass="32206" checksum="7778CDFDF352C1C1" modified="2018-12-05" version="1">MGKPRYASVAGRGEQLLAQTIRIFVKSWKSEAESGVTVKLGADPEFVLLSPEGKVVPASRYFPPDGAAGCDSVVVRGVRRWPLAELRPEPAAEPDALAADVRRLLATAARMTSGEPLSWLAGGAPVRGLPLGGHIHLSGAALTGERLRALDNAVALPLRLLEPPSAESRRPRYGSLGDFRKQPHGGFEYRTPPSWLVSRLVARGVMALSKVAAEHARELSAFRPLDEEAVREAFYGGDREVLSAACERVYAGIVRTSGYRSYAALIDPLFDAIRDRRTWNETDDFRRKWGIVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN75</accession>
    <name>A0A398CN75_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_28490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00364">
        <property type="protein sequence ID" value="RIE00364"/>
        <property type="gene ID" value="D3H35_28490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="122" mass="13501" checksum="49C936DFF16109DF" modified="2018-12-05" version="1">MAGFSRLCRLYDYLHHRVADVGPILIIYLAALQGVPHEMREAMMIDGAGKWKTFIHLTLPMIAPGITVNVLIGLANGLRIFDLPFALTAEGRPGRARRCRSKSTVTPSPRPSCPKGCRLRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN93</accession>
    <name>A0A398CN93_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_10400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03700">
        <property type="protein sequence ID" value="RIE03700"/>
        <property type="gene ID" value="D3H35_10400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="163" mass="18187" checksum="2DC6A5DBCF8F81DA" modified="2018-12-05" version="1">MRQGFILTGLALAVWIVSTLFFSLFGDWVLGEVGEANFGSSLFLLEILTFLVLIGLSLVVRLRLFPEKGSATRFGFTAAAVGLLLDTFTVMKREQVFPDFSEQQHHAWSVWMTLAYAMFLLVPAVVDRLVPEKKSDIRAEEPEELGLPEDETKASSYSAHAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNN5</accession>
    <name>A0A398CNN5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioredoxin-dependent thiol peroxidase</fullName>
            <ecNumber evidence="6">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_16605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.15" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02338">
        <property type="protein sequence ID" value="RIE02338"/>
        <property type="gene ID" value="D3H35_16605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="8"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="4">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="160" mass="18027" checksum="2D53B3F45ED4E4A4" modified="2018-12-05" version="1">MTESIKSIEIGKKAPDVKLPASNGETVKLSDFRGRKVILFFYPKDQTPTCTQEACEFRDAHSAFEEADTVLIGISPDPVKSHLRFIEKQGLPYLLLADEKLKAANAYGVWQEKQLYGRKYMGIVRSTFLIDKKGKLAKEWRNVKLKGHIEAVLEAAKATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNS2</accession>
    <name>A0A398CNS2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <shortName evidence="6">PBG</shortName>
            <ecNumber evidence="6">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="6">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hemC</name>
        <name evidence="9" type="ORF">D3H35_07935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="6">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the HMBS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03890">
        <property type="protein sequence ID" value="RIE03890"/>
        <property type="gene ID" value="D3H35_07935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="7">
        <location>
            <begin position="4"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="8">
        <location>
            <begin position="229"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="6">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="308" mass="33258" checksum="42B8CBBC6B2AAD2A" modified="2018-12-05" version="1">MRTIVVGTRQSALALTQTQQTIDKLTAICEQAGLPFAFEIKKIVTRGDRILDVTLSKVGGKGLFVKEIEQALLDGEIDCAIHSMKDMPFELPEGLVIGAIPEREDPRDCLVSLTARSVEELPQGARVGTSSLRRGAQLQALRPDLAIESLRGNIDTRIRKLTEEGFDAIMLAAAGLHRMGWKDRITAYVPPEVCLPAVGQGALAVECRADDEELLSLLARFDDDATRQAVTAERTFLGLLNGGCQVPIGAFAEVVEDQVKMTGMVASPDGLRILRESFQGQDPVSVGRTVAEALIGQGADRILAEARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP44</accession>
    <name>A0A398CP44_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endonuclease MutS2</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mutS2</name>
        <name evidence="11" type="ORF">D3H35_09125</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04142">
        <property type="protein sequence ID" value="RIE04142"/>
        <property type="gene ID" value="D3H35_09125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03280">
        <property type="entry name" value="ABC_MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00092">
        <property type="entry name" value="MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005747">
        <property type="entry name" value="MutS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF14">
        <property type="entry name" value="PTHR11361:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005814">
        <property type="entry name" value="MutS_YshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01069">
        <property type="entry name" value="mutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="10">
        <location>
            <begin position="714"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="619"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="522"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="334"/>
            <end position="341"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE04142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="789" mass="87358" checksum="2C64FA31695A5CAA" modified="2018-12-05" version="1">MNDKALYTLEYDKIIRRLAEATATSLGREHAEQLYPSPYLREVERRLAETDEAVRAVAIKGAAPFGGITDARPQLSRAKLGGMLQPSELMDIAQFIFGIRRLKRYVHTVKEEAAIPLLEDICEPLTEFKPLEDEIRRCIDEQGDVLDAASPELATVRREIRIGEGRAREKLESLIRSSSVQKMLQDAIITLRGDRYVIPVKQEYRSHFGGIVHDQSGSGATLFIEPEAVLQLNNKLRELKLREDKEIDRILRHLSARTGEHAGLLIEDAETVGRLDFIFAKASLANAYLGTLPAINDEGRLYLRRARHPLIPIKQAVPIDLELGEDYSAIIVTGPNTGGKTVSLKTIGLLSLMAMSGLFVPADDGSRLCVFDAIFADIGDEQSIEQSLSTFSSHMTNLISMVGQVTPKSLVLLDELGAGTDPAEGSALAIAILEHLHKIGCRIVATTHYSELKAYAYNREGITNASMEFDVATLRPTYRLLVGVPGRSNAFAIAERLGLPKSIIEHARGEVSEDELKVDTMIASLELDRRRAESERQLAERLRLEVEKLQTQVVEERTRFQEQKVKLLDEAREEARQSVAKAKREAEEIIADLRKLALEEGTSVKDHKLTEARRRLDDAVPAAAARPTRDPGSSPAKLEPGDEVKVYSLGGQRGHVVELSGALEAVVQLGIMKMKVKLTDLEPIRKDATAAPKRQVKAATAVKRTRDEDIRTELDLRGATLDEAIMDVDRFLDEAFLSNLGQVYIIHGKGTGALRTGIQEFLRRHKHVKSYRLGQFGEGGAGVTVAELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP60</accession>
    <name>A0A398CP60_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsD</name>
        <name evidence="10" type="ORF">D3H35_07155</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04363">
        <property type="protein sequence ID" value="RIE04363"/>
        <property type="gene ID" value="D3H35_07155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="9">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="91"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="199" mass="22772" checksum="1453A924E3CA7CE6" modified="2018-12-05" version="1">MSRYTGPKFKLSRRLGISLSGSGKELKRAFPPGQHGANQRRKVSGYGLQLMEKQKLRHMYGLNEKQFRNLFDRASKLQGKAGENFFFLLESRLDNLVYRLGWSNSRYGARQLVSHGHITVNGKKVDIASYTVVPGDVIGLRERSRGLKTIKEAIEGRHHLPGYIDFNANAMEGKYVRLPERGELSQDIEEQQIVEFYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP74</accession>
    <name>A0A398CP74_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_21275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03109">
        <property type="protein sequence ID" value="RIE03109"/>
        <property type="gene ID" value="D3H35_21275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="77"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="298" mass="33665" checksum="7293986798AC3F0C" modified="2018-12-05" version="1">MNTLPTKRKKWDSNMLFYAFLIGPPFLVLFLLTAGPLAISLGIGFYDWNLAKPHNTSFIGLDNFINMVQDKKFWKAVWLTVYQVGVTVFGQIVIGMGIALLLYREFTGIKLLRSVYMIPMMTTPIVVGLVWRMLYSTDSGVFNYWLGKLGISPINWLGNPNWAMPSVIMTDWWMSTPFVAIILLAGLQGLSNEPIEAAYMDGATKWQTFIHVILPLMKPIIMLAILFRTMDAIRRFDTIYVMTSGGPGNATETLNLHAYFHAFNYLNVGYSSALSTVMLIGIFACSLFILRKIQKVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPC1</accession>
    <name>A0A398CPC1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04010">
        <property type="protein sequence ID" value="RIE04010"/>
        <property type="gene ID" value="D3H35_08630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="183"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="385" mass="40808" checksum="EA0C64E2C6B0D001" modified="2018-12-05" version="1">MGRFAAAPFVQRLVEIRRHLHENPELSHEEYETTASIRGWLAEAGIRIADYPLKTGVVAEIGGFNGGPIVAVRADIDALPIQEETGLPFASRIPGKMHACGHDFHTAAVLGAALLLKEKERELKGTVRFLFQPAEEKAKGAGEVIASGALAGVRAIFGMHNKPDLPVGTIGIKAGPIMAAADGFIVEVEGRGSHAAVPEAGIDPIVTSAHIIAALQSIVSRNVGALDSAVVSVTRLNGGTAWNVIAEKAVFDGTLRTFDERVRLKVRERFEQIVAGVSSAFGASSKVNWLQGPPAVVNEAEWAAQAARTAESLGLTVIEPTPSPAGEDFAFYLQQTPGLFVFLGTSGPKEWHHPAFDVDEQALPIGASFFAALAVDALIRLTEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPE4</accession>
    <name>A0A398CPE4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Met) cytidine acetate ligase</fullName>
            <ecNumber evidence="1">6.3.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tmcAL</name>
        <name evidence="2" type="ORF">D3H35_07670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + cytidine(34) in elongator tRNA(Met) = AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:58144"/>
            <dbReference type="Rhea" id="RHEA-COMP:10693"/>
            <dbReference type="Rhea" id="RHEA-COMP:10694"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TmcAL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.-" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04453">
        <property type="protein sequence ID" value="RIE04453"/>
        <property type="gene ID" value="D3H35_07670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01539">
        <property type="entry name" value="TmcAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008513">
        <property type="entry name" value="tRNA(Met)_cyd_acetate_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37825">
        <property type="entry name" value="PTHR37825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05636">
        <property type="entry name" value="HIGH_NTase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="413" mass="45201" checksum="49CFC60D8F39BBDE" modified="2018-12-05" version="1">MPTVGVVVEYNPLHNGHLYHLQQSKKITGADSAVAVMSGNFLQRGEPAIVDKWARTEMALRAGCDLVLELPAAYSSQPAQWFAYGAVAVLSAAGIVDALCFGSESGDIEALNSAAALLTEEPEELAAALDAKLRTGIPYPSAYTGAAKELLQSRGLGQSAFALDQPNHTLGLHYMMAMRRIGSRMKPFTVQREKAGYSQESITDGAIASATALRKLLAESDSLQALAPFVPSSTLDILRRERDAGRAPVGWEHFKRPLLHELLRADVGALAGFAEVTEGLEHRIKRVLFEDAPSSVESLVNALKTKRYTRTKLQRTLLRILLGHRKDELTADRLESGVQYIRVLGFTERGQSLLREMKTRATVPVVLGAARGDWPYLSMDARASAVYALAFREEDSLRAAWRDYTMPPVRVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPH1</accession>
    <name>A0A398CPH1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04415">
        <property type="protein sequence ID" value="RIE04415"/>
        <property type="gene ID" value="D3H35_07465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="68" mass="7797" checksum="69A018C63A471C1C" modified="2018-12-05" version="1">MSVNMEKLVGRTAEIIYQDSKGAFTKRLVSVFSIRDGKARVLDWNKRAFRTLVVDRILDARPVTRDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPH9</accession>
    <name>A0A398CPH9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_13625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01827">
        <property type="protein sequence ID" value="RIE01827"/>
        <property type="gene ID" value="D3H35_13625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="6"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="441" mass="47238" checksum="6A01EC9AA2A32BD7" modified="2018-12-05" version="1">MNDKMVMPIWTFGLFIVVMNTTMFNVSIPSITADLHITADLASWIISSYSIGYALSTVIYSRLSDVASIRKLTTVGLLILGISSVLGIFARDFNALLGARILQSAGAGAMAGLGLVLASRYIPASRRGKAIAMISAGSAMAFGLGPIAGGLISEYFGWNGLFAVTCLVLAVLPVLLRLLPKEQPAAGRAFDVWGALLTVVNAASLLTAVTQQSALWLAVSIGSFAVHARHMKKAKNSFINPELLKQKGYGKLLTVGFCMLVLNLGNLFLMPLALAHLFGKSAMTIGLLIAPGAILSTFFTRFVGRWIDRYGNVRFLLIGQCMIAAVLVFFTFELAASPLVILCGYLVFSPAFSATMASINNETSLLLPQKLIGSGMGLLQLVQFFGGSVSVAICGLLLEYQMHASLANAYRHVYGLLFAVSLCSIGILLWYKHSSDARRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPR4</accession>
    <name>A0A398CPR4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_25680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00954">
        <property type="protein sequence ID" value="RIE00954"/>
        <property type="gene ID" value="D3H35_25680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="23"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="223" mass="24251" checksum="98E7607E91989549" modified="2018-12-05" version="1">MLLKYTWNWSFMEEYGSYFWTGVKMTLAVSVAAVIGGLIFGTLLSLLRLSKLWPVRFVGSVYVEVIRGTPLLLQLLLFYYGLPIFVGIDISAFSAAALTLIVNSAAYIAEIMRAGIQGVDKGQMEAARSLGMSGGMTLRLIILPQAFKNVLPAIGNELIVIVKESSILSVIGVGELIYQANAIRAATFTSLEPLLIAGGIYFVLTFTMSKLLGIGERRLRASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPU8</accession>
    <name>A0A398CPU8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_24310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01481">
        <property type="protein sequence ID" value="RIE01481"/>
        <property type="gene ID" value="D3H35_24310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="66" mass="7564" checksum="9974DD7FCAC1AD07" modified="2018-12-05" version="1">MRANSNGWQFLELASRLSETKEDQYRQLLALSTLIELLVDKGILTAEEIRSKASLMEAELDRQLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPW7</accession>
    <name>A0A398CPW7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-binding protein D3H35_21420</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rapZ</name>
        <name evidence="2" type="ORF">D3H35_21420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Displays ATPase and GTPase activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RapZ-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01014">
        <property type="protein sequence ID" value="RIE01014"/>
        <property type="gene ID" value="D3H35_21420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00636">
        <property type="entry name" value="RapZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005052">
        <property type="entry name" value="P-loopkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="66"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="296" mass="33265" checksum="9B44EF9119BF57DB" modified="2018-12-05" version="1">MDTLTSKPTLVIITGMSGAGKTIAVQSLEDLGFFCVDNLPPVLIPKFAELIDQSQGRIAKVALVIDLRGREFFTALSESLNYVREQFTIHNEILFLDAIDSVLVQRYKESRRRHPLAPEGMPLDGIHMERKLLEDLKGWATQVIDTSNLKPAQLKEKIIGRFSNLDKNAISINVTSFGFKYGVPIDADLIFDVRFLPNPHYVDTLRPKTGQDQEVYDYVMKWPDTQLFLTKLLDMLQYLIPLYHKEGKSQIVIGIGCTGGKHRSVALAEYLGKMLSAGETETVRVHHRDAGRDGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPY5</accession>
    <name>A0A398CPY5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stp1/IreP family PP2C-type Ser/Thr phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04502">
        <property type="protein sequence ID" value="RIE04502"/>
        <property type="gene ID" value="D3H35_07355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="255" mass="27522" checksum="23EE8362A4CA7092" modified="2018-12-05" version="1">MNTALLTHVGRVRQMNEDRAWSGRLSEGLTAVIVADGMGGHRAGDVASGLAVDSLSESLKLWDAAWSEEEGTANVRLMIRKANEAVYETASLNEKYHNMGTTVVLAVLTEQAGWIGHIGDSRAYRLRDGELEQLTEDHTLVNELTKTGQISPEEAAHHPRRNVLTRALGTDRDVPADVRTIDWRPGDRLMLCSDGLSGLVAKPLLEETLKQADVPLDRLAEQLVEMALEAGGDDNITVVLVGDVKAPNAAEGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQH6</accession>
    <name>A0A398CQH6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_22975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01254">
        <property type="protein sequence ID" value="RIE01254"/>
        <property type="gene ID" value="D3H35_22975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTHR12599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="SSF55248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="103" mass="11707" checksum="8F6DA4C05865A0A7" modified="2018-12-05" version="1">MDRNRLLTEDELAEQLALLKGWKAEEGKRIAKSYVFPAFAEAVAFVNRVAGIAETMNHHPFIAIDYRRVTLRLTTWHSGGLTHLDIDSAKAYDGEQNHLLDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQQ2</accession>
    <name>A0A398CQQ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Efflux RND transporter periplasmic adaptor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_06835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04490">
        <property type="protein sequence ID" value="RIE04490"/>
        <property type="gene ID" value="D3H35_06835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="68"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="116"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="358" mass="38960" checksum="0197C2940408F8EA" modified="2018-12-05" version="1">MKWWTEYSSRNNRKLRRPATVLTAVFLSAALAGCSVLPDEPEEEDLSAIQLPQISKKPEYDVTTKTLETKVSGSGKVMSTQERTLYFTLEGKRLKKLYVESGAKVKAGQPIAELDVEDLQKSLRTQSLEIKKQELAMKALLRTKDEMDPVDFEKQMLDFETQRQQLTELQADIAKATLTAPFDGTIVSVAVQEGALIKAYDAICVVANPSSLTVAATMSKDDLEKVALGMEVQVDINNAGQLKGKVKQLPQPQTDGNGQGGNGSAPLRLDQYLLVDVPDLPKTIERGTPLSVSVIVNRKKDVTVIPLAALRTVGARSYVQVVEADGTKREVDIEVGQMTSTDAEVVSGLTAGQKVVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR01</accession>
    <name>A0A398CR01_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_03230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04963">
        <property type="protein sequence ID" value="RIE04963"/>
        <property type="gene ID" value="D3H35_03230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1034"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1586" mass="181644" checksum="A0A1DCB26BC8F49F" modified="2018-12-05" version="1">MELKLVEIWRHVLGVSRVGITDNFYELGGHSLKATQLMSRIRKELDIEIPLREIFRNPTIMALSDSFQHFRTHRYSSIKNAPSSNHYPLSVQQKRMFILHKFEQESTRYNETICAQIKGSLNIDRVKEVIGTLISRHEILRSSIGIVNDEPVQTIHSDLEFEIWHKTLSDMKQLKQTIHEFIQPFDLTRAPLFRMGLVQVAENEYILICDAHHIITDGVSMNVLLEEFIELYEGGLLPPLPIQYKDYAVWQQDFMQSENIKKQEKYWLETYTGELPILEIPADYSRLVLQQAEGDQVSISIDKELSFQLNQKALESGTTLYMLLLAGYSVLLSKYTGQEDIIIGSPIAGRQQAEVDRVLGIFLNTLAMRTRPESNKKFSAFLREVKEFALQAYENQDYPFMELVEKLNLQRHLNRNPLFDTMFMMQNRNAIERKVQNISIQPFDFTHPSCKFDISLTAVETNKELEFKFEYDIALFRRETVERLAKHWVHLLREISSDNDKNLNEIEMLDDNEKSQLLHSFNDTTIVNGVVETSIVHLFEEQVKRTPNHVAVQFESSSLTYAELNALSNQLARGLKRKGVGSNRVVGVMVKRSVELFVAIFGILKAGGAYLPIDPEYPLDRIEYMLSDSCSGLLITQKQLIDMQDGFMGEIVFLEDGGVYDEDQSNLENRSNPEDLIYVIYTSGSTGKPKGVMIEHMAVHNFIHGMLDRIPFLSFNTVITLTTISFDIFVLETLLPLTQGLKVVIAGEHQQNDPEKLLNLIANHNVDILQSTPSRLQLLLNHNNADACLSHLKVVLVGGEAFSETLRERLLSFPKLLIFNMYGPTETTVWSTVAEINSSSSITIGKPINNTQIYILNSEQLLQPIGIKGELCISGLGLSRGYLNRPELTAERFVAHPFNHGERIYKTGDLARWLPDGNIEFLGRVDDQVKIRGYRIELGEVESALIAHDAIEEVSVIAREDAEGKKILCAYFIADEQLSAKILRSYLTRILPVYMIPSFFVQMERMPLTSNGKLDRKALPLLPGNIKTEVAYEAPRNKLEEILVNIWKEVLGVQRVGIWDNFFELGGDSISAIRISTRMQNYQIKMEVKDLFHHLCIGELSSYIYQNPIMINQEVVQGHVGLTPNQRRFFEYQLIEKHPTTQSIILFRSEGIDEVAVREVLGQIVTHHDVLRTIFSNTSGEFDSWIRGLEGELFQLKVYEESQGERIHEVIKARIDEIEESLDLSEGPLLKGGLFKTGQGDYLLLVVSRLVIDGESWRILLEDLNMSYDQILNNEKIQLPAKTDSYRSWARLLQDYTNSEQILNDILYWQNNGQIELKQLPKDYENEGSSYIDIGYESFDLTDQETEELLKNTHYAFNTDPNDILLAALGTAIYEWNDSNHVVIELDGYGRSSFKDQIDLRRTMGWFTNRFPIILETDPSKGLSYVIKSVKEQLRHIPNEGIGYGALRYSHTPSLATPLTDTIRPEIGYQRLVHFDQENQTEHFTTSSFDIGLSTNENIEGKVIIHMHGVVLDGRLRMTATYNRNVFSKVTISNFTVRYMHHIQSMIEHCLSVENKEKTPSDLSFNSISLDEMEDLKKSIVSLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR35</accession>
    <name>A0A398CR35_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KinB signaling pathway activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05025">
        <property type="protein sequence ID" value="RIE05025"/>
        <property type="gene ID" value="D3H35_02430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045881">
        <property type="term" value="P:positive regulation of sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024164">
        <property type="entry name" value="KinB-signalling_activ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14089">
        <property type="entry name" value="KbaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01251">
        <property type="entry name" value="KbaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="203" mass="23025" checksum="4EA9CEE04D68A5F2" modified="2018-12-05" version="1">MNLRKWMRLFGLTILTGGLVTTVAGVIMVLMDPEFRNIEADGWLFNIVMMALSGLALGAFAHMGFFAYLTLNYIARSIFKRPYLWVTFQGFVTVFVLVEIMINLYDTNFPQATFWLLPLVLVALAAIVGWFKVRETSRGAWIPSFFFMVTITVLEANPGFKSGSLSSLVYMLLPLFICNTYQIMQLHRLLGTPAEKERTLQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR92</accession>
    <name>A0A398CR92_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03308">
        <property type="protein sequence ID" value="RIE03308"/>
        <property type="gene ID" value="D3H35_11505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="137" mass="15040" checksum="7C46BF22F0C30479" modified="2018-12-05" version="1">MVGSWRWNGFFGGFGAALVFLFSLSRNPIGTTLLRSFYAFVAFFLIALAIRFVLGVLLHPSSGQTPEGKLEEERGAVLDMVTPDDDESLTEMLKEQWTDGSSGSASGFKPLAPKRLVSIDDADPEQVVQAIRRLNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRQ9</accession>
    <name>A0A398CRQ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_12555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03478">
        <property type="protein sequence ID" value="RIE03478"/>
        <property type="gene ID" value="D3H35_12555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="22"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="265" mass="29854" checksum="7E3A51AC0C7F5056" modified="2018-12-05" version="1">MITLSGIEKTFKVAKRATGLRHAVRSLFYRDYTMVEALRDISFTIAQGEIVGYIGPNGAGKSTTIKVMSGILVPDRGDCEIMGYTPWKDRVAYVRNIGVVFGQRSQLWWDVPVLDSFELLRDIYDVPQSEYGRNLELLVDTLDLGDLLQTPVRQLSLGQRMRCEIAASLLHGPSLLFLDEPTIGLDAVSKIAVRRFIQTINREKGVTVILTTHDMSDIEALAHRVLLIGKGRLLYDGNLEAMRTRFSTDQIDEAVVKLYEEYELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRS7</accession>
    <name>A0A398CRS7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02487">
        <property type="protein sequence ID" value="RIE02487"/>
        <property type="gene ID" value="D3H35_17470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="258" mass="29201" checksum="B8A1973FB5A60626" modified="2018-12-05" version="1">MTRKERLLQRLDGIGKSLEKKGDALLLLGLGSVGSETDRLDDYSDIDFYVIAAPGCKDRFIDRLDWLEDAHPLAYSFKNADVGHKVLFEDGIYGEFAVFEETDMDTAGYSKGRIAWKHPSYENDGIVNPKVPFPQLTSESVDFALNEALTNLYVGLCRYARGEKLSASRFIEGHALNNVLSVLHLLEPKVDYYPDPFGNERRLEKRYPRFADRIGGMMQGYDKAPESAVRMLEYMEEVYPVNGRLAEEIRKLASGQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRW9</accession>
    <name>A0A398CRW9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01674">
        <property type="protein sequence ID" value="RIE01674"/>
        <property type="gene ID" value="D3H35_22960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="167" mass="19390" checksum="A3ADE9DCB5CADFDF" modified="2018-12-05" version="1">MNEAAPFFRIDSMTENDAKKICEWRYPEPYDVYRWLTWDEMVRQAKEFGDPDIRSQQFRSFRSAENDLVGYAQLFPLDRAIRLGIGLRPDLCGRGYGTSLIRLAAELARSRMPPDGEVDLEVERWNVRAIRAYEKAGFRITDEYERRASHGMVSILCMVWMPGAASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS17</accession>
    <name>A0A398CS17_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CsoR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02161">
        <property type="protein sequence ID" value="RIE02161"/>
        <property type="gene ID" value="D3H35_15545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="115" mass="12902" checksum="7A6ECB6CDE05714E" modified="2018-12-05" version="1">MSEGTDLIDQRTEEEGCCSSDHSERKSHHSDSVKRNITSRLNRIEGQVRGLKGLIEKDAYCDDVLHQIASVQSALNGVGKLLLEHHMKSCVVERIREGDTEVLTELLTTVNKLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS69</accession>
    <name>A0A398CS69_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MGDG_synth domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_15915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02221">
        <property type="protein sequence ID" value="RIE02221"/>
        <property type="gene ID" value="D3H35_15915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009695">
        <property type="entry name" value="Diacylglyc_glucosyltr_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06925">
        <property type="entry name" value="MGDG_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGDG_synth" evidence="5">
        <location>
            <begin position="19"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="244" mass="27927" checksum="566E169025DB152A" modified="2018-12-05" version="1">MNRQPNKIMILYARFGEGHYQAASALRDSFARLGNAEIMLIDLLAESHPFINEFSRFVYRKSYTMWPQMYGWVYEATRGMKADSLFAHWLHSFGTVTMQRVVEREKPDAVIHTFPMMVMPTVTNRLRKKIPMFNVVTDFDLHMRWVHPDVDKYYVATEDMAEQLLNLGITAERVAVTGIPIRSSFAPGRVHESAAFRYGLEPYRPTVLVMAGATEPYPEYARRSGSLPPAAKRRRRSSAAGIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSA7</accession>
    <name>A0A398CSA7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PspA/IM30 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_18630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02677">
        <property type="protein sequence ID" value="RIE02677"/>
        <property type="gene ID" value="D3H35_18630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31088">
        <property type="entry name" value="PTHR31088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="94"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="221" mass="25971" checksum="FCFBB7BE1FE9D90C" modified="2018-12-05" version="1">MSVIKRVRDMTVATLNDRLEKAEDPVRVIDQFLWSTHQEIVQSEQLQRQYAGHTDSLYRQWQDAAAWAAKREHQALTALKAGEEHVAKLALQDKVAQEERAARYQELYQQSQSELNELEQLLQELRNEYRSVYDRRQFYVARMESLKLQQRLNARFGPGQTDPSQMFRKIDDRISDIELETRSLRDLRRMGLETALHAGSFVQETIERELNLLKQKLKQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSE3</accession>
    <name>A0A398CSE3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000004">
        <property type="protein sequence ID" value="RIE05452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05452">
        <property type="protein sequence ID" value="RIE05452"/>
        <property type="gene ID" value="D3H35_00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="103" mass="12294" checksum="F533B730586BD141" modified="2018-12-05" version="1">MIAKLSHDLTPLTTIADMRSALSKKRLPTKENLRLSLIERKTDYLGQSDRKFNLLFSLLTSANIRIVSSASISSDWRERIRRWYRYSSKRLRDRLRIVRERRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSF8</accession>
    <name>A0A398CSF8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tunicamycin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_03005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05140">
        <property type="protein sequence ID" value="RIE05140"/>
        <property type="gene ID" value="D3H35_03005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="198" mass="22879" checksum="BE3F72D89778C18D" modified="2018-12-05" version="1">MIIWINGAFGAGKTQAAHELHRRLSHSFVFDPENAGLYIRKNIPKEVFKDDFQDYVMWREFNLAMLKYIDAEYDGILIVPMTVANPLYFNEIIGSLRNDGIVVNHFTLCASKEVLLRRLRSRGEGGQSWAARQIDRCLAGFEDEAFRHHLQTDLMSIEAVAETIASMCDLPLLPDRRGAIRKRIDRVKTQIKHIRFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSP6</accession>
    <name>A0A398CSP6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF350 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_14540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0719 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01984">
        <property type="protein sequence ID" value="RIE01984"/>
        <property type="gene ID" value="D3H35_14540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007140">
        <property type="entry name" value="DUF350"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03994">
        <property type="entry name" value="DUF350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="134" mass="14632" checksum="AE879B393238E1CF" modified="2018-12-05" version="1">MTIDQIVGTLVWTAAGALLLFILMGVDSFFTKYKDLEEMKNGNTAVAIRFVMKLCAQGYILARSIQTSDDLGEALLVSFVSFVILFVVEWAFRYILRLLADLRLDEGVHQGVVGLGLVAGSFHLVGAFIIGACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSU2</accession>
    <name>A0A398CSU2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_01535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05230">
        <property type="protein sequence ID" value="RIE05230"/>
        <property type="gene ID" value="D3H35_01535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="343"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="377"/>
            <end position="384"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE05230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="597" mass="67206" checksum="462C210C69B25874" modified="2018-12-05" version="1">MNSLRRYFSFCQESFLLVWNKRKGYVIAGFILGICLSVQTLVTVRLSKAVIDSLTSGHAQAFYMLLVSLMLFRIVADCMYSWKDHLDRTMDRVVQLDVKSDFVDSLSKLDLLAKEHPAFMQRSSEWELASGKRAGVYQRLNAIVQNVVILLLNNVFLLATHWLVPLFVLSIAIARIAIDYKIVPKRLKLTSLSQKNIVETGYFYNLLTGGPHQKELTVMGVFPFMKAKWLAKANEASGFQGQMDSLSIRARYFSGTVSTLGTTAVMGIVGTQVFASSLTLGDYVAITMAIGLVEGSIVTIFQQFVHIYEDLKYVSGVSTSSDEHHLPANTSRSIAPFPSFRQIEVKNLSFTYPNSNKPALNNISFTIRQGEKWAILGDNAAGKSTLIKLLIGLYRPPNETVYYDGIKQEQLNMDELWKNTSVLFQDFKQYMLSVKENVSLGVAEELCREDRIKSMLGKVGLPNVLRMAKGIDTRLGWLSDDSINLSGGEWQRLVLARTWMKNADLVIFDEPTSALDPNSELELLQEMLNLAERKTLIVISHRVGIASKVDHILLMRNGQIIESGTHELLLKQRGAYFEMWEKQAEWYVGKSKEGMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSV0</accession>
    <name>A0A398CSV0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_16975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02401">
        <property type="protein sequence ID" value="RIE02401"/>
        <property type="gene ID" value="D3H35_16975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="237"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="447" mass="51411" checksum="5D6850B558FADAA8" modified="2018-12-05" version="1">MWALVLIFLIILSIIFSFFLKKENMFWIVVILASVAIGVMADILRISYLPDEVLVGTGQLAVIFVLFSFIFFHVPVYAFLMLAFSLYRMPPILRKMVILTGLLPLVYDASHTSFIPSYEINYLFLFWLWLLYIISGSLLIVLKYIRTPPSFEKSHYLSIIIVYVPHPWLALFTFILPLSLHGVGGEWPYFRITLQLSVSLAFMLNLYYILFPGFFGVRLSSIRRKTKSRLVASGVEILNHSLKNEANKMLFIARELKMMELDQKERSQYIDLIEQSAKEMSATLEKLNTKTRKVTINLGVHTVEQLLDNVREKCAMLLHQRNMHFTISSAFAGTLHCDLQLLSDDLYSLIDNAIYATAKCEEPTIRIEVGTYGRYVYISLWDNGCGISKDNRRRLFEPYFTTKNKSSNFGVGLFACFNNISAQNGLIHIESEEGAWTKVNIYIRKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT64</accession>
    <name>A0A398CT64_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Copper-containing nitrite reductase</fullName>
            <ecNumber evidence="5">1.7.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_20695</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Fe(III)-[cytochrome c] + H2O + nitric oxide = Fe(II)-[cytochrome c] + 2 H(+) + nitrite</text>
            <dbReference type="Rhea" id="RHEA:15233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(+)</name>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.1" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03017">
        <property type="protein sequence ID" value="RIE03017"/>
        <property type="gene ID" value="D3H35_20695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050421">
        <property type="term" value="F:nitrite reductase (NO-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001287">
        <property type="entry name" value="NO2-reductase_Cu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00695">
        <property type="entry name" value="CUNO2RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="109"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="242"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="348" mass="38980" checksum="B87B14FD541A2A75" modified="2018-12-05" version="1">MAFNVNRPVSRREALKWGAAGALGIIGGTLLSPGSWFGKTVKAMDKHEVHSALQHQRHQTMAHGYDPGTERTAGLDAAVKSLTQFDYGTKSVRADGRTVREYELVAADSTVEIAKGITFPGWTFNGTIPGPTIRCTEGDIVRIKFWNGSSHPHSIHFHGIHPTTMDGIEPVPSGTEFVYEFEAKPAGMHLYHCHIPPLSKHIHKGLYGNFIIDPVKPRKPARELNMVMNGFDLDLDGENEIYTVNGYAFAFQAWPIEVKVGELVRVYLSNFTEFDLINSFHLHANFFHYYEVGADPEARPLYTDTIMQCQGQRGILEIVFPEPGKYMFHAHQSEFAELGWMGFFEAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTG9</accession>
    <name>A0A398CTG9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_05555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04559">
        <property type="protein sequence ID" value="RIE04559"/>
        <property type="gene ID" value="D3H35_05555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="158" mass="18084" checksum="99109128A7AF7C21" modified="2018-12-05" version="1">MEARIDKVKQQLQAQGYKLTPQREATVRVLLENEEDHLSAEDVFMLVKDKAPEIGLATVYRTLELLSEMHVVEKMNFGDGVARYDLRTDNNKHHHHHLICVQCGSMSEIMEDWLTPLEEKLEREYNFSVLDHRLDFQGICAKCNAKNAAESNPGSTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTQ5</accession>
    <name>A0A398CTQ5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hisC</name>
        <name evidence="6" type="ORF">D3H35_03995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04659">
        <property type="protein sequence ID" value="RIE04659"/>
        <property type="gene ID" value="D3H35_03995"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="5">
        <location>
            <begin position="30"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="365" mass="40164" checksum="C49D81B0DE03B428" modified="2018-12-05" version="1">MQPKPNIVGLPVYQPGKPVDDVKRELGLSEVIKLASNENPFGCSPKAKEAIVRELDNVSIYPDGAAVELTAAIASYHGVNTDQIIFGMGSDEIIMMIARAFLLPGDETIMADLTFPQYKHNCVIENAVIVEVPLKKGTHDLFGMAQRVTSKTKVIWVCNPNNPTGTIVTADEVEWFLSNVPPHVLVVLDEAYCEYIDDSSYPNGLKLLEKYPNVVLLRTFSKIYGLASLRIGYGIGRPDVIRFINQVREPFNTSRFGQAAALASLADESFVADCRNANREGLAQLRSAFERLGLEAFPAYGNFIMVDVKRPAQEVFDSLLRKGVIVRGGFKLTPTHLRITVGSREENDKVIAALEAALQEIAVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTY1</accession>
    <name>A0A398CTY1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylneuraminate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02424">
        <property type="protein sequence ID" value="RIE02424"/>
        <property type="gene ID" value="D3H35_17105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="302" mass="33305" checksum="9426FB8697D96769" modified="2018-12-05" version="1">MTVLAAFEGIYVAMYSAYDDDGNIDRDRVKKLARYYAGKGVKGLYVGGSSGEGMLQSAEERKLVLEAVMEEVKGELTVIVHVGANSTRESVELSKHAEQQGADAISAVPSIYYRLSEAAVENHWQHMIDSTRLPFIIYNIPQTTGFGLSYDLCRKMAKQDKVIGVKMSGESTFELQQFKEAGGEDFLVFNGPDEQFLAGRMMGAAGGIGGTYGIMPELFFALNELYSQRKLDEAQSLQFKINAIIKKLLGYPSLYGACKHILSIRGIETGQPRLPLLPVRPEHYESLAALNVEIEEAISSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUH4</accession>
    <name>A0A398CUH4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_20190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02931">
        <property type="protein sequence ID" value="RIE02931"/>
        <property type="gene ID" value="D3H35_20190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="266" mass="30526" checksum="7190DE388DEED850" modified="2018-12-05" version="1">MPIERSLPHYYQSFSKELEVTKDRVRNIIGKAHWISDGTHKEAILQEVLRRFIPQKYVVSSGFILSNDGETCSKQLDIIIYDQASPLVFNSSNFVIIPSQYVRAVIEVKTSLSVGAKLTDALENLSTVQKIMDQTSDYVYFGIFSFGYQNFRSIGPVTVAQRLFTRISEFYRNKRLQDTHLTDLQYLQRRTLTSLCMNGQLYGLHWNGSTQIEPEFGLYDTGEQSFNFFVSNLLSTLDNSTISQSKPLWFPESKQSRVLLKKSISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUH5</accession>
    <name>A0A398CUH5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0102 protein D3H35_11295</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_11295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0102 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03507">
        <property type="protein sequence ID" value="RIE03507"/>
        <property type="gene ID" value="D3H35_11295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00252">
        <property type="entry name" value="TIGR00252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="115" mass="12750" checksum="E30FBFCDA6C1E8B8" modified="2018-12-05" version="1">MTGLRGEEAAASYLQSLGLVIVERNWRCRSGEIDLIALEEAVLVFVEVRSRSSTNRFGTAIEAITPRKCRQVRDIASIYMRMKGESNRSVRFDAVAVTFSADGEVAEIKHIPGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV31</accession>
    <name>A0A398CV31_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_02985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05139">
        <property type="protein sequence ID" value="RIE05139"/>
        <property type="gene ID" value="D3H35_02985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="121" mass="14110" checksum="C441E95D43BE255D" modified="2018-12-05" version="1">MGTGKGMELTGCYFENVIFDNCSLEGAMFSESYFYNCSFRNVNLSGARFSGYFENILDFTDVQLHGSHISIYTDQDSYERLRQDRNFGNKIKFVRAKEKSDLEISRESYKKNALRRSNMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV94</accession>
    <name>A0A398CV94_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_20320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02954">
        <property type="protein sequence ID" value="RIE02954"/>
        <property type="gene ID" value="D3H35_20320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="88" mass="10330" checksum="97CF7B986A7E3793" modified="2018-12-05" version="1">MKYIKADTVFPEELLAQIQKYVQGRLVYIPNPEGFRKKWGENSGSRTYLSLRNSEIRRQFDEGKTIGDLMDDFSLSYDSIKKIVYSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVP2</accession>
    <name>A0A398CVP2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fibronectin type III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03937">
        <property type="protein sequence ID" value="RIE03937"/>
        <property type="gene ID" value="D3H35_08205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017430726" evidence="1">
        <location>
            <begin position="28"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="922" mass="102305" checksum="EFB5ACD250BFA317" modified="2018-12-05" version="1">MFHKLIRIITISAFILFCCAPSLSTNAEELDPASDTSVPLQIPADAELKQPPAIDASTPIFGSDDFNPDKLQAGTEGTSRTRIELIEKRTRNSKQFVLGDGTFQTEYSMTDIHYEDANGQLQDMDTSLIDEDEIELLPNTTLSKEVFNDVEKVKQKKKQGKLDRSETDFMALRLPFSLKLPKKIYKGYSIGHGKEKLTFIPVGVSEASKGVKPADGSKNKLLYAEVWQNTDIELIATSQGVKENIILKSEQSPSQISFELRGNLNDRLSNESLRIMPAWLEDNHGVRRDVIITKRNERDRTYLDLTWDSAQLSYPVTIDPSTEIVDGNDDTFVDSGNPNTSYGDDPLLTVAKLGATNGMYSTYRYKNAYTRFSLSGIPSTGTTITSSVLRTKVISVSDYYQATIQPYRVAQTWNKYTTYSNAPLRVTTNPGSAVNVMQVGGVQYVYFDVTEMTKDSFSGGEISIGLYSVGDNINHTGANVSFASFSYPGGCSCDNVKLIVNWSNSEVPSPSATITSGIAYTTPYPKVTWSYSGTLNQVKYLVTVSKVNGTETYSSQDQLSSANEHTFLSALSEGTWTVKLKVFNGESWSSEVTQTITVNALPTISNFRVDATVENSLTLAWNVSNPYQVKYQIVGMKKGYWETYDSGIVTSSGTSHSVSLLRGEYEFALRVYNGASWTPWSIVNSATVNGKGLVYTYNASNQLSQLESFVTGAKINFQYDNNGNLTKRSISVPPQNTLIADGNPVEWVTRTKLIEDGYDDFINMADKQPERDIRRVYIDQDASYVYLMIELGRVTDYDLLYPHGYNDDNYFVYFPMTGATTYSSVTRNNTSVGTLKAYYEIASWHENDVTVHKYNNGSWQWMWTGTPESDGIGSKRIVNGTKVAASAILELRVPLNQIPGADLSKAFVVAASDTKDVDIAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVU2</accession>
    <name>A0A398CVU2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trehalose utilization protein ThuA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03997">
        <property type="protein sequence ID" value="RIE03997"/>
        <property type="gene ID" value="D3H35_08550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009381">
        <property type="entry name" value="Trehalose_catabolism_ThuA_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030013">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThuA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="243" mass="27766" checksum="23564ECB1B783AC5" modified="2018-12-05" version="1">MSQSINVTVWNEYRHEKASEKVASVYPQGMHTAIAEGLEITGQIRTATLDEPEHGLTEEVLNDTDVLIWWGHMAHGDVQDDIVERVYNRVLKGMGLIVLHSGHFSKIFKKLMGSSCDLKWREADEKERIWVVNPGHPIAEGIGEYIELPKEEMYGEHFDIPQPDELVLVSWFEGGEVFRSGCCYTRGAGKVFYFRPGHETYPTYFNPQVRKVISNAVKWAAPVNREYPKYGNAQPLETIKEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWG5</accession>
    <name>A0A398CWG5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA internalization-related competence protein ComEC/Rec2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_05955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04167">
        <property type="protein sequence ID" value="RIE04167"/>
        <property type="gene ID" value="D3H35_05955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030420">
        <property type="term" value="P:establishment of competence for transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07731">
        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035681">
        <property type="entry name" value="ComA-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004797">
        <property type="entry name" value="Competence_ComEC/Rec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025405">
        <property type="entry name" value="DUF4131"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13567">
        <property type="entry name" value="DUF4131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00361">
        <property type="entry name" value="ComEC_Rec2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="7">
        <location>
            <begin position="578"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="860" mass="94046" checksum="3FB9814DD3A3117A" modified="2018-12-05" version="1">MGRRPLVLFAVCWLVGASAPSLLSFAGSLAALAGAAFLLIGTTAFRRISGKLALLCAAALFLSFGHRMWAEQGNQTKLSPDASDAARTEAVLTGRLLSPASVDGDLVVFRIAANVADLGLTGEWTNVAGERLAVRVKLKERTEQAAAKKWKRGMTVRIGGVLERPGSAGNFGTFDYRAYLERQQVHWQLTAEGAASVIITKRKPPLFVRPMQWIDFLREAIGERMNRLFPNGDAGYMKGLVAGIQEDIDPGQYDGFSRLGLTHVLAISGLHVGVVVFALLRFGAVLRLTRERGMELTIAAMPVYMLLTGASASAVRACLMAMIALALARRNQLKDGLHLLAAAALIMVVGKPAIVEEVSFQLSFAVTAGLLLFVPLVAAWLPIRWKPLRNALAVAITAQAASFPLSAYYFHGLHLLSLPANLILVPFISFIVMPLGLAAILLGSLWLPLGIVPAKIATVCNEMTFRIVGQFDNATRLQTVWPQSNWHWVVAAYLLMGLTALWLRRLLEARQWAEQEAAFEAEETVPLREAGLEEFGVGKPFAVAGMLLLSAWGGWLLWGIKPAFLDLTAKAMFLDVGQGDSILIRTGGGRYALIDTGGAVSFRKPGDEWRERRDPYEVGRKLLVPLLKQRGVRVLEALVLTHLDQDHIGGAEAVIRNVPVRRIVFNGTIKDASSVRKLFRLALDKGIPLFAARAGTTWRIDGSASIDVLYPERHPGDAVSFEDEQNDRSVVLKLALYGRTFMLPGDLEAAGERNIATAYAADRSRPSPEPVDVLKAGHHGSKTSTVAEWLELWTPREAVISVGRNNLYGHPHLTVLNRLDEYGVAYFRTDRDGEIQYRISPSGKLERREKRAAEEVPSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWW5</accession>
    <name>A0A398CWW5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05068">
        <property type="protein sequence ID" value="RIE05068"/>
        <property type="gene ID" value="D3H35_02755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="39"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="363" mass="40463" checksum="AD1CA71FD511FB2B" modified="2018-12-05" version="1">MAKRRREGIHVVDIDEQYEQELDKAVKVLSAKQNESTLNFVFVTDLHHIQGGNQLRAARIIRELAARLPLDFILNGGDSCINAAKDVALAAQREIFEALRAPGVPLLTVKGNHDDNSIYGHERPETRAGHVIYPAETKALIQEGIPQAARWDESCPDSLYYYLDVEAKQTRVIVLDTMNIPYEAGSDGRLPYLGQWEYAFSSRQLNWLAHEALNLTGKPDWRVLIASHVEIIEDGVFGTDHPVANGEALWEIVKAFQSGSPYSLTGGEGDFAYAVEGDFSPQGKGKVIGCLFGHVHFDQTVYQDGIPMVSSLNACTRKEFPDCPEREPDTLSETALDIVTIDFERSRIDTYRFGAGEHRTVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY22</accession>
    <name>A0A398CY22_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_04160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04687">
        <property type="protein sequence ID" value="RIE04687"/>
        <property type="gene ID" value="D3H35_04160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="105"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="498" mass="54831" checksum="95BCA4652B68FA75" modified="2018-12-05" version="1">MRNIRGFGKEIALGFLPVLIAFLIFAGMPALPLIMGALMVAAIFMFARSRGGLAMSAAGKKPSAREPDYMSFEDIGGQEQAKRELSEALEFLVQRDKIEKLGIRPMKGILLTGPPGTGKTLLAKAAAHHTQSAFVAASGSEFVEMYVGVGAGRIRDLFKEARNLAVKQKRDSAIVFIDEIDGIGGKRDGGQHREYDQTLNQLLTEMDGIQGDEKVQILLIAATNRKELLDPALLRPGRFDRHIQVDLPDKTGREHILQLHARNKPMREGVSLSRVAEETFGFSGAQLESVMNEAAIYALRAGSDRLDSEHLSQAIDKVMMGERMDRETTHEERERVALHELGHAIVAETVRPGSVAQVSLTPRGQALGYVRHHPRKDSYLYSKPVLEEQIMIALGGSAAEEMFYGGRSTGSRGDFEQATNIVRTLIESGMSGLGIVHPQALTQEQWSKENEAILSELTDRTRKLLADSKLAFEQLLDTLIQEETLSGEQLRSKLQHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYV3</accession>
    <name>A0A398CYV3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_07445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04411">
        <property type="protein sequence ID" value="RIE04411"/>
        <property type="gene ID" value="D3H35_07445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="247"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="731" mass="81588" checksum="10F2DF963CC2F48F" modified="2018-12-05" version="1">MLSGDWIPLTLPADMKEHFEGVRVTSLGGATEATVWSNFYPVEELDPEWVSIPYGKPIQNARYYILDSRNEPCPTYVPGELYIGGECLAAGYTDAALTAERFVADPFVSDENARMYRTGDLAKWLPDGTMIFLGRADNQVKIRGFRIELGEVEAQLLKHASVKEALVVDRTDRNGHKSLCAYFTADRDLPSDELKKHAVASLPAYMVPSHFVRLEAMPVTSNGKIDRKKLPSPQEAAAVASDGPVAALSTAQEQRLAAIWREVLDIGEVGAEDDFFDLGGDSLQAVQVVAKANEARIKLSLRDMLHYRTLRAIAEHGGGEEVAETGTNVELAADQVAAAASPAISRRYNTGFMEPDVKIPYYYPCYLGAVYAKLTYEHAYSLPRSFLPFGDGFGIISYGFHDDGQLDSRLQYCDVSYTGGFRLGDRFAVTSSFISFDTMEEGIEWCEERLRENKLIVMMGTTYYLNYCQDYLIGEEKFAEMLKNREALDDGRGGDSQHAHMFVMVDHSDRGYVVYDTSFNFFGTIPELDLKRSFAGVKGLSFLQNDDEIKFKNAGNAVIDIRLDGFVPMPVEQMGLEMLERYIEICTGIRPGEEPIGGLKGFLGLEGVKEAVRTFSECGDGEAAVLFSLVLFNNWKYKNIFLRDFLQDLSKLVAMDSLSALLQEVENAVAVLGGWHERTEANKELYAQPGNPEFSAFRSSVAQQLTEMYAKQAEVLRRVHEEMNKRREEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZA8</accession>
    <name>A0A398CZA8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05187">
        <property type="protein sequence ID" value="RIE05187"/>
        <property type="gene ID" value="D3H35_02115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="183" mass="21048" checksum="26B76BC2F96C87A9" modified="2018-12-05" version="1">MKNILILNGHQKYNSTDGKLNRTLVEEMLASLRPVHNVQLTVLQDGYRIEDERQRFLRSDVVIFQTPIYWFNVPGLLKTFMDEVYEYGTFFKGTDSYGTGGLLTDKEYMFSATWNAPEHAFNDPSQFFQGGGLEDALAHLHRTQRYIGMKPLKSYACYDVIKNPSIDKFVSGLRAHLREIGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0N8</accession>
    <name>A0A398D0N8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_02720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05061">
        <property type="protein sequence ID" value="RIE05061"/>
        <property type="gene ID" value="D3H35_02720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="62"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="329" mass="35851" checksum="113CF81A4CC410D1" modified="2018-12-05" version="1">MVLNGRYIISITIIMVSIIFFLISINERNLLKQEKIKQITAQGLSVRKYLGLEADGFKKFQGAGVNVAIIDTGIAVHDDIKSNRILEFKDFVAGKNEPYDDNGHGTFIAGIIGADGKVKGIAPKVNFVVIKAMDKSGDVDKDRLIIALEWLVENQKKYNIKVVNLSLGGSPFIKNNDDLLLKKVHELDQAGVIIVTSAGNISSRYNTILSPGTSSDVVTVGGVKNNRTYSIQDDKLASFSPEGYRQNGIIKPDIVTLGVDILSLDYKRTNSYITHSGTSVSTAIVSGAAAIMFEKYSVSSSSIKKIIINNAIKLKNESELKQGNGELHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBZ3</accession>
    <name>A0A398CBZ3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_27335</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00676">
        <property type="protein sequence ID" value="RIE00676"/>
        <property type="gene ID" value="D3H35_27335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="447"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="707"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE00676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="959" mass="107582" checksum="205AE4756B0E539E" modified="2018-12-05" version="1">MLKRVLVVCLAAILYSSLIPLSIMWDKDGNRGGLQVRSGVLDLSQWNNKKQRIVKLDGQWEFYWKRLLTPESFQSTTADKPEADAFMKVPSQWNNRWVNGEYLDAYGYATYRMVLKNLPVGGVFALKKANVRFSSAIYVNGHKLLEDGKPSANASDYKYGNMPQIGFFQADRGDVEIIVQAANYDYVNAGIPLSLLFGEQSAMLDMQQKTVAREFAVLAILGGLALLFLICFVAAALYFKKDYTLLVFSGICVLYALYNGLNGERALTLLLPELSFEVIYKAKDILSLVCIAVLTVFFYQLQKSIISLKLMQLISAVMGISILFTAILPIRDYLNLQTYVIAIYEVLIVWLLIKIALMYIRSDKAERAKSFMLFMIILPINLYSLDIILFALSYRENLWLSQFYIVAFTIIVIFLIVLRFFEAYRTVDEMKNQLLRMDKIKDDFLSNTSHELKTPLNAIVNITDTLLQGVAGPITGKQARNLGIVLGSGRKLSLLVNDLLDYSKIKHGDIALFRQSLDLRAAVNSIIRVHSFLLGGKEIKLENRVPESFPSVYADGNRLSQILHNLIGNAIKFTDFGEVAVTAGVIGDMAEIRVSDTGIGIASSMHERIFKAYDQGDESIALQHGGTGLGLSITRTLVELHGGKISVESSPGLGSVFTITIPLFSGAVTDSAIGESWLMEDREFSMPDAGSLQVEYPIRIPGKIDEPILVVDDDYANLQSMINLFALEGYTIVVVNRGQLAWDELARNPDYFLVILDITMPDMSGFELLQKIRERFSPSELPVLMLTAKNRVAEMKLSMENGANDFVGKPFEAEELMARVRSLTRLKASVKNAKAAEIAFLRSQIKPHFLYNALNSIAELCVDEPEQAEQLTLQLSQYLRSSFDFKQLDSLTTLDNELKLVEAYVRIEKARFGDRLRVIYDIDANPAIRIPPLILQPLVENAIRHGLMSNQRGERCAWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCX7</accession>
    <name>A0A398CCX7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3906 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00563">
        <property type="protein sequence ID" value="RIE00563"/>
        <property type="gene ID" value="D3H35_27895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024998">
        <property type="entry name" value="DUF3906"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13046">
        <property type="entry name" value="DUF3906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="70" mass="7907" checksum="ACEA988764C43033" modified="2018-12-05" version="1">MFLYKLEVSLSDRQIVMIIMGDSDQEVMDSVEDHLSKHYIGTPDIVEIALVEKRRANKGAAYVIECGTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEM3</accession>
    <name>A0A398CEM3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00895">
        <property type="protein sequence ID" value="RIE00895"/>
        <property type="gene ID" value="D3H35_25310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="101" mass="10633" checksum="8D38226A93874D4F" modified="2018-12-05" version="1">MELRKQRRKSLTERLNRAGRGGESRPVSGKGKKSSGCGFGSFAARLSYGGGWKWIYVGQSSGPGMWLASGLTLLAGAASLLLGMDSPIAGVGTASLWRLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEQ8</accession>
    <name>A0A398CEQ8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein SprT-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_25575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SprT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00935">
        <property type="protein sequence ID" value="RIE00935"/>
        <property type="gene ID" value="D3H35_25575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00745">
        <property type="entry name" value="SprT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023524">
        <property type="entry name" value="Uncharacterised_SprT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SprT-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="165" mass="18903" checksum="56FF44570C6C907E" modified="2018-12-05" version="1">MDNQELQIWVEKVSDTFFGRPFKHEATFNPRLRTTGGRYFTRSHNIEISPHQLAVHGPEETEAIIKHELCHYHLHLLGRGYQHRDEDFKRLLAQVGATRHCRPLPGAARRLPVKYLLICQACGMSYPRKRRADPRKYACGRCRGRLALIDAKPAAESPEPQPAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF55</accession>
    <name>A0A398CF55_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Prephenate dehydratase</fullName>
            <shortName evidence="9">PDT</shortName>
            <ecNumber evidence="3 9">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pheA</name>
        <name evidence="12" type="ORF">D3H35_27640</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="3 9"/>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00522">
        <property type="protein sequence ID" value="RIE00522"/>
        <property type="gene ID" value="D3H35_27640"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00858">
        <property type="entry name" value="PREPHENATE_DEHYDR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="10">
        <location>
            <begin position="8"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="11">
        <location>
            <begin position="211"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="8">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE00522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="295" mass="32708" checksum="C43F82EA42E3562D" modified="2018-12-05" version="1">MSRTDKRRSVAVLPQGTVSDEAIRYFFPDGATDFVYCKMISDVFQSTASGNTDWSCIPIENTIDGSVSLHLDWLVHEVDLPIRAEWVYPSIQNLIGSSKELGGENGSWDPLKITKVMSHPVAMAQCYQFLRARLPHAELETLPSTSTAVRAVKDNPGKGWAAIGTKLAAADNELDLLEEGITDHDNNFTRFLLVGSVPYERPATKLLKTTILVNLPEDYPGALHQVLSAFAWRRINLSKIESRPTKKKLGNSYFYIDIELSLDSVLLPAAIAEIEAIGCQVRILGSYPSVPYVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFK6</accession>
    <name>A0A398CFK6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-layer homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00682">
        <property type="protein sequence ID" value="RIE00682"/>
        <property type="gene ID" value="D3H35_27370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="16"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="75"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="140"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="194" mass="21105" checksum="99479BBE250C9449" modified="2018-12-05" version="1">MEADLQQGGVYALLEYSVNFADVQQTHWAANTIRVLAAKHLVNGVSESEYQPNRMMTRAEFVQLAAAALNLKDKGELSFNDVTVGAWYEDALSKMVKAGLVSGRSADRFEPNAMISRQELVIILMRAYKLQNGTEPSTGGVSFNDEASIAPWARESVQAASALGLVNGRSGGRFAPNDSATRAETAQFILNYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFP5</accession>
    <name>A0A398CFP5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_24645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01543">
        <property type="protein sequence ID" value="RIE01543"/>
        <property type="gene ID" value="D3H35_24645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="396" mass="46188" checksum="07979B9990CB9B70" modified="2018-12-05" version="1">MTTIPENMLNDLFENLVTQFVKQNIETIMRAEIKHMLEEQEEHQRNSRNGYYTRTLHTKYGHIEDLQVPRDRNGQFQTSVFEPYQRRDGWLEEAVIQMYKSGMGTRDVARFIESMFGSQYSPTTVSNITATVLEDIQIWLQRPLKKRYSVIYLDGLYVKLKRGTVSGEVVYFAMGIDEDGHRQILGFYIGGQESSNGWREVLKDLYIRGATDVLLGVFDGLTGLEAAFRETYPKADVQHCVVHKVRATFPKIRVQHRTEVIEDIKTVYTAEDKDLALAAFDTVYAKWGKLYPKEMELWKEQLPTLLTFYKFPSLIKEAIYTSNPIERMNKEIRKRLKPMNSLTNMDAAEKIVYLQAIDYNERNESRAIRGFADPEVKKKLTEMFEARYSDKITSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFS5</accession>
    <name>A0A398CFS5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Esterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01285">
        <property type="protein sequence ID" value="RIE01285"/>
        <property type="gene ID" value="D3H35_23145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="224" mass="25433" checksum="61BCDD9400AC62A9" modified="2018-12-05" version="1">MKSTIMRIEGFRSENLNNERDLFIYLPPGYTESEDRRYPVLYVHDGQNLFHPAMNGQSWNLHRTADRLIANGSIEEIIIVGIANMGAERANEFMHPLDGVLYQNDKENITPRGILYERFLIGEIKPYIDGMLRTKPGAADTALMGSSRGGKVTYHIGIRRPDVFGKLGILSPYFYYVNPLSLEEHRMYASFPSKSPLSKIWIDLGVGKVCLSWRNTSGRSCPKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFU5</accession>
    <name>A0A398CFU5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_23260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01305">
        <property type="protein sequence ID" value="RIE01305"/>
        <property type="gene ID" value="D3H35_23260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="153" mass="17582" checksum="2F75C6771B623A82" modified="2018-12-05" version="1">MWVKERLKEYAKGKRQLEASRKLLSPDHPDQVHLAGMISDMAYAIKWMQSGRQPGIYRGVERRGMYREPFVLDKDLFPSLQEAEPVSPIRLTTEQRQAALEAIRAMSDRERDCYLLYATQGLSYAQIGSALGLSRYTVKEYVQRAKSKAQQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFV4</accession>
    <name>A0A398CFV4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_23320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01315">
        <property type="protein sequence ID" value="RIE01315"/>
        <property type="gene ID" value="D3H35_23320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044016">
        <property type="entry name" value="Big_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001220">
        <property type="entry name" value="Legume_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19077">
        <property type="entry name" value="Big_13"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00139">
        <property type="entry name" value="Lectin_legB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017484583" evidence="3">
        <location>
            <begin position="28"/>
            <end position="3685"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="4">
        <location>
            <begin position="2691"/>
            <end position="2785"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="5">
        <location>
            <begin position="3519"/>
            <end position="3582"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="5">
        <location>
            <begin position="3584"/>
            <end position="3642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1159"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1349"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1550"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2387"/>
            <end position="2472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2484"/>
            <end position="2567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2601"/>
            <end position="2625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3661"/>
            <end position="3685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1349"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2387"/>
            <end position="2438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2451"/>
            <end position="2465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2484"/>
            <end position="2533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2546"/>
            <end position="2560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="3685" mass="379884" checksum="EC261402DCA3D072" modified="2018-12-05" version="1">MCRSLNKSALLLLIAVLVITSMGFAPAKARASTPETRYLTLKHDDFSATQDVDGTIPGKSPEKWLQRNGNAAVATDSQGRKVLRVTPNQANMTGSAFHGNMISFGKDRSFSTYFTFRMSDISTSTYSAGDGLVFSIQTLSKEAGVKGGGMGYGGMKRSFGIEFDTFANSATVAGDPLDPKAIGVNSGGTANASRGGNATTYDTSHVAVVADGNVDHSKSTTSPKGKVFPASVGGSTSNPSIIATPTAGETVPIYNFKTADTGTWASNNAFPFYNGEIYHAWIVYNGPTDTIEVYMGKNGTFDASKLKIKKSGLGLREYLEQDEAYVGFSAATGSAFENHDILKWYLNNNDLPIEPENPNYNYQVAPPLISITSTDYAVYGSTTSTTSRVITAQLKNYDGSNWSSGPYPVTFSLFKEESAKSYTITKTDGSTQVVSLKPRVDDTRVALKGESRRTNADGSSMRYATVMSDANGVATIQISNTLSTAITDSNVKAIVGDHYGNGVNGGGAYDEKPVTFAADTAPPTITSAAVDVSNPNHVKAFLSEYVLYPTDRTHPENWVAGNSSTWNANGFNVLIPDVSNPGAYVSVPATIVGGSGAPTEPLVLELASGTVVPFGYDVKLQYVKASGSLQDAAAQLVQDQTLFVDDYPFTPKGAAVVNNQARKTVEVSFNFPVRDNAVTPGSFKVYYNTGSGKTLATVTGAVSDGTDSKKLLLTLGTAIPAGATVTLDYVVPGSGGKVTNVTIDGLSAGHHTLKALTDFSVANQMAPTQAAVVADANRNKVKVVFGSEVELQGAAATLATAFKVGISSQGGLIDVSNVAIDSSDATGKTLILTLGGANLPSGGVPYGDTVTLNYNSTIVSAGVKEKNGSQRSLEWLTNFPVANQQILNVAIVSPANGSTTNNPNTVITGTSQVGSTVTVTVKDSGNHTVAGSTTVVPATGNWTFTPASPLADGTYSVTAVATDASDNKGTAASTFSVDTEAPDVDITGPANNSITNNPNTVITGTSDPGSIVTIVVKDSDNTTIAGIKTVDPVTGNWTFTPDDPLLDDTYTVTATAADGHGNTGTDTSTFTVDTIAPSIVIVSPADGSTTNNPNTVISGTSEPGSAVTIVVKNSSGTTIAGNKTVNPTTGAWTFTPNAALADDTYTVTAEATDAAGNTGTDTSTFTVDTQAPNVDITGPVNNSVTKDPNTVITGTSDPGTTVTIDVTDKDGDPVDGTLTVNPTTGNWTFTPDDPLTDGQYTVAVEANDGHGNTGTDTSTFTVDTIAPSIVIVSPADNSTTNNPNTVISGTSEPGSAVTIVVKNSSGTTIAGNKTVNPTTGAWTFTPNAALADDTYTVTAEATDAAGNTGTDTSTFTVDTQAPNVDITGPVNNSVTNNPNTVITGTSDPGTTVTIDVTDKDGDPVDGTLTVNPTTGNWTFTPDDPLTDGQYTVAVEANDGHGNTGTDTSTFTVDTIAPSIVIVSPADNSTTNNPNTIISGTSEPGSAVTIVVKNSSGTTIAGNKAVNATTGAWTFTPSAALADDTYTVTAEATDAAGNTGTDTSTFTVDTQAPNVDITGPVNNSVTKDPDTVITGTSDPGTTVTIVVTDKDGDPVDGTLTVNPTTGNWTFTPDDPLTDGEYTVAVEANDGHGNTGTDTSTFTVDTVAPSIVIVSPADNSTTNNPNTVISGTSEPGSAVTIVVKNSSGTTIAGNKAVNATTGAWTFTPNAALADDTYTVTAEATDAAGNTGTDTSTFTVDTQAPNVDITGPTNNSVTKDPDTVITGTSDPGTTVTIVVTDKDGDPVDGTLTVNPTTGNWTFTPDDPLTDGEYTVAVEANDGHGNTGSDTSTFTVDTVAPSIVIVSPADNSTTNNPNTVISGTSEPGSAVTIVVKNSSGTTIAGNKAVNATTGNWTFTPNAALADDTYTVTAEATDAAGNTGTDTSTFTVDTQAPNVDITGPVNNSVTKDPDTVITGTSDPDTTVTIVVTDKDGDPVDGTLTVNPTTGNWTFTPDDPLTDGEYTVAVEANDGHGNTGTDTSTFTVDTVAPSIVIVSPADNSTTNNPNTVISGTSEPGSAVTIVVKNSSGTTIAGNKTVNATTGAWTFTPTNPLADDTYTVTAEATDVAGNTGTDTSTFTVDTQAPNVDITGPVNNSVTKDPDTVITGTSDPDTTVTIVVTDKDGDPVDGTLTVNPTTGNWTFTPDDPLTDGEYTVAVEANDGHGNTGTDTSTFTVDTVAPSIVIVSPADNSTTNNPNTVISGTSEPGSAVTIVVKNSSGTTIAGNKTVNATTGAWTFTPTNPLADDTYTVTAEATDVAGNTGTDTSTFTVNTQAPNVDITGPADNSVTNNPGTVVTGTSDTGTTVTVVVKDSGDNPVDGTLVVDSVTGNWTFEPSDPLPDEEYTVTVEATDSHGNTGTDTSTFTVNTNRPNVDITGPADNSVTNNPGTVVTGTSDPGTTVTIVVKDSGGHPVAGTLDTDSSTGNWTFEPSDPLPDEEYTVTVEATDSHGNTGTDTSTFTVNTNKPNVDITGPADNSVTNNPGTVVTGTSDPGTTVTIVVKDSGGHPVAGTLDTDSSTGNWTFEPSDPLPDEEYTVTVEATDSHGNTGTDTITFTVDTNKPNVAVVSPSNGSTTNNPGTVITGTSEKGSDVSVTVNGGTVTGSLSVNTNTGNWTFTPDAPLADGSYTVVANAIDEAGNTGTATSAFTVDTQAPNVDITGPANNSVTKDPNTVITGTSDPGTTVTIVVKDNSGITVDGTPTVDLVSGNWTFTPNGTTGFADGTYTVTVEATDANGNTGTDTSTFTVDTQAPNVAIVSPANDSTTNNRSTVITGTSEPGSQVTVIVTVGNSTVAGHLAVTSATGNWTFTPNTPLADGTYTVTAEATDAAGNVADTESTFKVKVTYFITLIPSPAMLVADGHSISVLTAKVTDSAGNLVSGIDVDFSAVIQGTSTPKGRFVDAAGQVLGTPRATTVNGVATIRFQSESIHSVVSVNVDIKAAVHDTVHDIHAESTITVVFEPAVVSGIITDGANHQPLAGVTVTLLDANDQPIPGRTAVTDEDGRYTLPITEGNQTYKVQVSKTVGTGSSAVVVTYVQEVAVNDGISGLGQQFVSDQTIAGIIGGKRPDGSMQPIDFGSFVGNNNGGANPGFGMFLKDGAEYVSSSGGTVDVPGESDGFSINGQGVFVAGGLTAGKTYELQVRYYYDVRNGNGSVTREFIVIAKKTVTVSVSGEMNINEELIDPFGVITDSVTHAIIPNAHVVLKYADTARNRSKGITPGTTVLLPTLAGFEPANNANPQNSSSTGNYAFMVYGNTDYVIEATATGYQKYRSTVISVEQDIVRWDFEMNPVVTTPGGGGGGPIIFPPVDPEEPVTEKVVADITVNIAVERSTYEEGSEAPVVILYKNEADKPLAAGQLKVTLPDNVTVIDADGGKVTGNVIVWEVKDLAAGQIVSHRIRVKFPNIDAVEKVVTLKAEFVVDGELLHPENAKSSVKALVFSNRYGNERHTRFVMGYPDLMFKPEKSLTRAELATIIAHLLGEYDSGTTKNYSDVSNKFWAYKYIQTVTRHGIFSGYPDGSFHPNDPVSREELAVVMAKYLQLDVAKPIESRFGDAKGRWSSPYIEALNRNSLISGYPDGSFRPGNNIPRLEAVTMIDRMLFRGPLTNVSPSFPDVLKSNWGFGYVEEASRSHESTRNPDGSEVFVKSIEDNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG61</accession>
    <name>A0A398CG61_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_15815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02206">
        <property type="protein sequence ID" value="RIE02206"/>
        <property type="gene ID" value="D3H35_15815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="5">
        <location>
            <begin position="153"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="220" mass="24428" checksum="DFB9923284CF3AAF" modified="2018-12-05" version="1">MLRIIIADDQTLMRDGLQTILQLEDDIEVVATAENGEEACQLALQLRPDLVLMDIRMPVMNGIEAVKKLHEQAPDTKVLMLTTFDEDDYIIEALASGAVGFLLKDIPTNKLLQAVRDAAKGEMMLPSSIAVKLANRLASPSAHRPAAPGRMRGKTTDLKFTEREMSIIALMVEGRTNRDIAQLLFMSEGTVKNYISTIYDKIGTNDRTQAVIWLKDMTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHA1</accession>
    <name>A0A398CHA1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">hflX</name>
        <name evidence="10" type="ORF">D3H35_15365</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02133">
        <property type="protein sequence ID" value="RIE02133"/>
        <property type="gene ID" value="D3H35_15365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="9">
        <location>
            <begin position="199"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="158"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="205"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="259"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="325"/>
            <end position="328"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="345"/>
            <end position="347"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE02133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="424" mass="48003" checksum="F889B04654CDBD4D" modified="2018-12-05" version="1">MEQTQQKAIIVGVELHSKPDFDYSMEELRNLAAACDVEIVDSLSQKANRVNPSHYIGTGKLEELSTLLEAHEASVFVIFNDELSPSQIRNLEAKLQRKVIDRTILILDIFAERAQTREAQLQVEVAQLQYMLPRLVGLRESLGRQGGGAGLKNRGAGETKLELDRRRIEERITALQSELEKLVATRQIQRKQRRKNAIPVVCLVGYTNAGKSSLMNVMVDTYNPGSNKHVLVKDMLFATLETSVRSIELPDRKSFLLTDTVGFVSQLPHHLVKAFRSTLEEVAEADLLVHVIDYSNPEHKQHAAVTEATLKELGAEHIPTIYAYNKLDLTDRDYPQIQEDGVYLSAKKQTGIAELLQLIRSRIFNDYVQCEVIIPFDQGRLVAYFNEHAHVQSTTYEPEGTRLKLECKAADFEKYRDSFVLIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHC9</accession>
    <name>A0A398CHC9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Urea ABC transporter ATP-binding protein UrtD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">urtD</name>
        <name evidence="5" type="ORF">D3H35_23730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01382">
        <property type="protein sequence ID" value="RIE01382"/>
        <property type="gene ID" value="D3H35_23730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017781">
        <property type="entry name" value="ABC_transptr_urea_ATP-bd_UrtD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03411">
        <property type="entry name" value="urea_trans_UrtD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="261" mass="28771" checksum="53BDF3622D0D5B06" modified="2018-12-05" version="1">MSSSAILSCEKVTVAFDGFKAVQGMDLKLEKGELRFLIGPNGAGKTTMLDVICGKVKPVSGKVAFESRSGTIDITRRKEHKIAELGIGRKFQAPSIFAGLTVGENLEIAMSQNRSVWATLRASMSKTESERIEAELELIGLQDHRALRAGLLSHGQKQWLEIGMMLLQEPEILLLDEPVAGMTDKETDKTGELLQQIVQKRTVVVVEHDMEFVRNFASKVTVMHEGKLLKEGSMDDVQKDDRVAEVYLGKRRDSDVVGSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHT5</accession>
    <name>A0A398CHT5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01572">
        <property type="protein sequence ID" value="RIE01572"/>
        <property type="gene ID" value="D3H35_24815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017291121" evidence="1">
        <location>
            <begin position="30"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="441" mass="48547" checksum="9E06EE0EE8EDF307" modified="2018-12-05" version="1">MVGKKWAFLTLASITILSACSSGNTTNEASQSSEKGTEKTGAKKLTVWVKQTFSAEADELLKKRMEQFGKEKNVTVNVELISSSSMTEKYSAAIESKQTPDVAFLIPEVIKQFQEKDLLLDLSDLSNNINKVNGELFKKGLDYASVDGKIYGIPLYNSATVLFYRKDMLAKAGYDAPPKTWDEFREVAKKVTETNKGVYGAGLVFGSANDSENEKRSITWSLGASLNSADGKTPTMDTPEMSSVVKMLTDMVVVDKSVPPTSVSWDDSGNNKAYLSGQTAMIINAASVVGALKDAPDDVKNNTGVAVLPAGPKGTTVIGSTNYNGVFKNTKEPELSQELIQYVMDKSWYKTWIETVAPTFAPVYIDLANEPFWQSEYNKPIIASLEYFTYTGYPGPNMSQATEVHNQKILTQMYQRILVDKISIDKALKEAQDKMLKIYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI59</accession>
    <name>A0A398CI59_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_20340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02956">
        <property type="protein sequence ID" value="RIE02956"/>
        <property type="gene ID" value="D3H35_20340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="100" mass="11692" checksum="38A5CDD0D4F35B17" modified="2018-12-05" version="1">MPGEHEQKLIEDYVAVTGSMENNQELLRKLSKYKNDTNSINRIALDTLQRVITEQLENNKLVNWIYKLVYPHPHYKEIRMNGDRSGINVKDVTSNVILDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIC2</accession>
    <name>A0A398CIC2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenylate/guanylate cyclase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_27040</name>
        <name evidence="3" type="ORF">D3H35_28040</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00588">
        <property type="protein sequence ID" value="RIE00588"/>
        <property type="gene ID" value="D3H35_28040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00625">
        <property type="protein sequence ID" value="RIE00625"/>
        <property type="gene ID" value="D3H35_27040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007890">
        <property type="entry name" value="CHASE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05226">
        <property type="entry name" value="CHASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01080">
        <property type="entry name" value="CHASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="425"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="606" mass="67810" checksum="646D80DFE77E17A1" modified="2018-12-05" version="1">MRDRIKRIAILLNVVLLLAVGIVYANGLLKPIDYLFFDYNMKKAADHNPHESIIVVGIDEDSLAELGRFPWDRAVYPPFLDAMNQPENEPKAIVFDILFNEASEDEASDDALAESFSQYSNIVLPVIGITEGDVFGTTVVRRHELLTAYQLSKPLKKFADHTHLANINRVISDDGVIRQTWLKIKTEDGTVIPSLGYEAAKMYGADLSKYDDMTDPGKKIAKNTITIDYQLSTADFMTIPFISVLNGEIDPTVFKDAIVLVGFTSVGVGDESGQDSGITPIEKNMKLVYTHANIVNQLLKGSEVNYTPKWIEMLLAFTLFLFFIWLPWRTKNVVSFLVFAASLTAVYFAQFVLYESQATSMSIANIALAAILAYLANLSLKAYSESVQKSFVTRQFGRYISKDLVKQIVDQNIDIELGGDLKEITILFLDIRGFTPLSEKLTPPELVDTLNTMFNMITETTLRNEGTIDKFIGDAAMILFGAPLELKNHERMAVKTAYEIQQGMNKIRDNIIEKYGVEVNVGIGIHTGKVVVGNIGSYLRVDYTAIGDNVNIAARIESQTKKGQVHVSEQVYEKVKEHFLFDEGEDRMFKGKSHPIRVYEVLGVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIP4</accession>
    <name>A0A398CIP4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GIY-YIG nuclease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02250">
        <property type="protein sequence ID" value="RIE02250"/>
        <property type="gene ID" value="D3H35_16075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="127" mass="14936" checksum="CFBD7BA469556A65" modified="2018-12-05" version="1">MNRKKELQRQYKEETKIEGGVYAIVNNRNGRRLIASTPDLKSLNGRRFMLAMGSHTNRELQREWNEYGADSFEFEVLEKLERKENESIYYDMKDELVKLEQSWIDRLQPYGERGYHGNGGDAGKDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIP5</accession>
    <name>A0A398CIP5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_17280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03166">
        <property type="protein sequence ID" value="RIE03166"/>
        <property type="gene ID" value="D3H35_17280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="57"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="250" mass="27057" checksum="B70B5F2068319E18" modified="2018-12-05" version="1">MRRSLSAYVPVLVFVLLLAAGWEAGTTIFDIPHYIIPKLSDVLVSMWDNGRLLGKHFVVTLGEALLGLGISAVFGVLAAVWIESSGLAKKTIYPLIVMSQTIPIIALSPIMVMWFGYEIWSKVAVVILFTFFPIAVNTADGFRSADPDIGELMQTMGAGKLDRFLKWKIPSALPGFFTGLKMAAAISVGGATLGEWLGGETGLGMYTKRASNMLRGEAVFSGVLLLSAMGVLLFLAVQWVEKATLVRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJB9</accession>
    <name>A0A398CJB9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03416">
        <property type="protein sequence ID" value="RIE03416"/>
        <property type="gene ID" value="D3H35_12175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="48"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="227" mass="25882" checksum="5E09B1D9E4111F64" modified="2018-12-05" version="1">MGMEWYDAIARRNGGYKSNAIYSVEGQSGEQVFEERLKELLAFSKHALDAGCGHGDFTIRMSSFGSRITGLDNSIEMIKLAEASLHDTPNPAIRFIHATTKEKLPFEDGEFDLIYNRRGPTSILNHARILKPKGKIIGIHTGAMEVVKERLASNEFVNIEVEIFDQAMIYFPNDRELAKFLTGVPGNIDYTNPDNIELFRARKEPFILHDGRLGMREWKYIWTAEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJG7</accession>
    <name>A0A398CJG7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
            <shortName evidence="7">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">serS</name>
        <name evidence="10" type="ORF">D3H35_23350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01319">
        <property type="protein sequence ID" value="RIE01319"/>
        <property type="gene ID" value="D3H35_23350"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43697">
        <property type="entry name" value="PTHR43697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="172"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Serine binding" evidence="7">
        <location>
            <begin position="231"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="45"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="349"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE01319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="428" mass="47990" checksum="B6AF5B0C9A9923F0" modified="2018-12-05" version="1">MLDVKLLRNDYEKVAIALRNRGASLELIEPFPALDSARRENLTESDRLKNRRNIVSQEVAKLKKSGGDADELIAEMREANDRIKQLDEEIRELEAKVDELLLAMPNIPHESVPVGASEEDNVELRKDGRPREFAFEAKPHWDIAAGLGILDFEAAAKVTGSRFVFYKGLGARLERALINLMMDLHSDQHGYEEILPPYIVNRDSLVGTSQLPKFAEDLFKIEGTDYFLIPTAEVPVTNFHRDEILTLEDLPKKFVAYSSCFRSEAGASGRDTRGLIRQHQFNKVELVQLVAPETSYDVLEQLTGHAERVLKLLGLPYRVLALCTGDMGFGSAKTYDIEVWLPSAGTYREISSCTNFEDFQSRRAAIRYRPENGAKPEFVHTLNGSGLAIGRTVAAILENYQQEDGTVVIPEALRPYMGGIEVIGQRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJM5</accession>
    <name>A0A398CJM5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_17675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02520">
        <property type="protein sequence ID" value="RIE02520"/>
        <property type="gene ID" value="D3H35_17675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004761">
        <property type="entry name" value="Spore_GerAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34975">
        <property type="entry name" value="PTHR34975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03845">
        <property type="entry name" value="Spore_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="292" mass="33206" checksum="1007447498972802" modified="2018-12-05" version="1">MLVFSFFFIHVVAYLLREFVDLFTLAYLIKTPSWAVASLLMFAVACISQIGAWGIFRFAQACFLLIGFMFLILPIYLHGELNPTVWHGIWRLSEGKAIWQMTYNITPWYGELFLLLFFIPELKRAASVRGTIWFASIAGTYILTSVFLLSLLVFGPNLAGGLTYPLLELTGFIRIGDFMQNLDPVIVTIWFTAFFIKLSILFYSGVLTFSHALAIKEHRIFSMPLAALTVVMSIVIAPNPVEMNRFFDRSWSTFALFVECLPFIYVLAAWLRKRAKSAESNAKKPGEAEVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJY6</accession>
    <name>A0A398CJY6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YwbE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_24405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01499">
        <property type="protein sequence ID" value="RIE01499"/>
        <property type="gene ID" value="D3H35_24405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019240">
        <property type="entry name" value="DUF2196"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40069">
        <property type="entry name" value="PTHR40069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09962">
        <property type="entry name" value="DUF2196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03833">
        <property type="entry name" value="TIGR03833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="73" mass="7765" checksum="7CF57C889B9412D7" modified="2018-12-05" version="1">MAGNGKNRSDVRPGLTVDIVLKQDQRTGALTRGVVKDLLTNSAFHPHGIKVRLQDGQVGRVQAIVSDADSGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK01</accession>
    <name>A0A398CK01_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AbrB family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00207">
        <property type="protein sequence ID" value="RIE00207"/>
        <property type="gene ID" value="D3H35_29670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="87" mass="9736" checksum="68097477D1EF0DDE" modified="2018-12-05" version="1">MSRMIEMERKVTKFGNSLGITMTEALKKIGLELGDTVIVDVRDDNSEIIIKKANKVTLPAGIGTDFMDTLSQVMEQYDETIKGLKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK79</accession>
    <name>A0A398CK79_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_29325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000060">
        <property type="protein sequence ID" value="RIE00297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00297">
        <property type="protein sequence ID" value="RIE00297"/>
        <property type="gene ID" value="D3H35_29325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="3">
        <location>
            <begin position="13"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="204"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="422" mass="47361" checksum="362C870634361994" modified="2018-12-05" version="1">MVWTMPYSARSYQARPSEIAGIEQMIGLFINTIPVRIQSRPGMSFSDLVKQVQLSSLSSAQYDYYPLYEIQANSPLKQGLVNHVMVFENYPIGEAIEQSSGQSIGFTISNVETFEQSNYDFCVTIVPGNEIRIKFSYNAARIDRGMVARIRGHLQEVIGQVLETPHVHIDQLEIVTEEEKRQLLHEFNDTKASYPADQTIHGLFEEQVKKTPDHTAVVLESESLTYAELNGRANQLARVLRGKGVGADRIVGILAERSLEMIVGILGILKAGGAYLPIDPDYPAERIGYMLEDSGADILLTQKRLEAKTMGFAGEVLHVDDERLYALDDTNLEHTGSSKDLAYVIYTSGSTGKPKGVMIEHDNVVRLFFNDRTPFQFSYKDTWTLFHSFCFDFSVWEMYGAILYGGKLIVVPKRSAKIQGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKA3</accession>
    <name>A0A398CKA3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage tail protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02582">
        <property type="protein sequence ID" value="RIE02582"/>
        <property type="gene ID" value="D3H35_18025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011747">
        <property type="entry name" value="CHP02241"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010667">
        <property type="entry name" value="Phage_T4_Gp19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38009">
        <property type="entry name" value="PTHR38009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06841">
        <property type="entry name" value="Phage_T4_gp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02241">
        <property type="entry name" value="TIGR02241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="144" mass="16102" checksum="D3F9C2A53BE29DD0" modified="2018-12-05" version="1">MPGERNDPYRNFRFRVEIEGLQQAGFSEVAGFDASFDVVQYREGNEVITPRKLPGLARYGNITLKWGATESVELYEWLQECVNGTVERKTVTIIAIDEEGGDVATWQVIEAWPTRYTAPSFNGSGAEVAIELLELAHEGMTRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKM3</accession>
    <name>A0A398CKM3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9 10">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">recF</name>
        <name evidence="12" type="ORF">D3H35_23980</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the RecF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01428">
        <property type="protein sequence ID" value="RIE01428"/>
        <property type="gene ID" value="D3H35_23980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00617">
        <property type="entry name" value="RECF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 10" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="SMC_N" evidence="11">
        <location>
            <begin position="2"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE01428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="372" mass="41796" checksum="5E6FC641872E86D0" modified="2018-12-05" version="1">MHLKSLELQGYRNYDSASLSTGSGVNIFIGPNAQGKTNLLEAIHVLALTKSHRTSKDRELIGWNGDSAKIRGELERKYGNVSLELQISSQGKKAKVNGLEQRKLSGFVGAVNVVLFAPEDLDIVKGSPGVRRRFMDMEIGQVHPGYLHDLQQYQKVLQQRNNYLKSTDASRASPELLDVWNEQLATYGVKMMQKRKNFMYHLQRWAEKIHAGITGGTEKLTVEYQPSFGSPNGDAFQDHSSLFGQFMLKLTQGKEQEFRRGATLTGPHRDDLTFAINGKDVQSFGSQGQQRTAALSLKLAELELMHEEIGEYPLLLLDDVLSELDQTRQTQLIETFQSRVQTFITTTGLESVNMNRLKDAAVFHVRNGELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKZ6</accession>
    <name>A0A398CKZ6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BMP family ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_27920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BMP lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00567">
        <property type="protein sequence ID" value="RIE00567"/>
        <property type="gene ID" value="D3H35_27920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017403605" evidence="4">
        <location>
            <begin position="25"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Bmp" evidence="5">
        <location>
            <begin position="53"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="351" mass="37014" checksum="1629663F209D7BBC" modified="2018-12-05" version="1">MKKSVKLFTGIALAATLVLSGCGKKEDPNNEGAASPSASSSATSDGSGAGKKFAMVTDVGGVNDKSFNQSAWEGLKELTSTTGAETKYLESKEDANYLTNLNQFLGEGYDLTWGIGFLMGDAVKQAAEQNPDAKLAIIDNEVKAPNVESVLFAENEGSYLVGVVAGLMTKTNKIGFIGGIDIPVIKRFEKGFLAGVKEVNPKAEVTVNYTGAFDKADLGKAAAATIYNDGADIIFHASGGTGDGVFNEAQERFNNGKKVWVIGVDKDQSLTFGDDITLTSMMKRVDQAVLSVSKDLLAGTFNGGKVTTLGLKEEGVGLPETSKKNVPEDILKKVEEYKAKIISGEIKVPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL50</accession>
    <name>A0A398CL50_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_25130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01628">
        <property type="protein sequence ID" value="RIE01628"/>
        <property type="gene ID" value="D3H35_25130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="322"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="486"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE01628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="589" mass="68868" checksum="3E11E2D5A52FCD0C" modified="2018-12-05" version="1">MNMKTIYHRMKPKRLKGKLFLSMLVFIIFPLILLNIYLFNEFEVALQDKIVAQSSKGLDQLKQSTEDLMSLVYKTLVMVQNDNAIHNVLTEPEKYTVLDRIHRTEHVLKNIDNSIFLFNSQIVYYTLLDLNGNVYTSFQPQEMLNYDTLKSESWAQQLNADRPYMWIANDPNYVSRDITSSKYLLTLSSTMRDTNKTPFSLARISIDYEAWFKASVQSNEEHQYYIINHAGMLVSSFNSEQALDSRILSFFSENTEKSGFYFDQSTDSLINYRSIPQLDWYFVDVIPRKVLFNEVRLLKIKFFSIFFAFIVLFIGINMFISYKFTKPLTVLEKKMSSIVNQNLKLTISEKNYTGEILQLIRSFNQMSTDMNKMVKLLKDEQKQREMVHFQMLLSQINPHFLLNTLNTIKWLAIRKGDKDIPDICVSLGHILETSLHSEVELIFLKDELKLIEDYLLIHELRFNDQLNVQYEYSSGMDYALVPKLSIQPLIENSIIHGIAPLKGQGMITVRIFTQNKLLYIEIEDNGVGIKEQNRQQRERSRKGIGLQNLKERLHILFKEDGLLEVVPLEQGTLVRMQLPYLLSSPYERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLC6</accession>
    <name>A0A398CLC6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Altronate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_20720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UxaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03022">
        <property type="protein sequence ID" value="RIE03022"/>
        <property type="gene ID" value="D3H35_20720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11613">
        <property type="entry name" value="SAF_AH_GD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007392">
        <property type="entry name" value="Gal/Altron_deHydtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044144">
        <property type="entry name" value="UxaA/GarD_SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04295">
        <property type="entry name" value="GD_AH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAF" evidence="3">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="502" mass="54355" checksum="30D333FBE1D7FB5B" modified="2018-12-05" version="1">MNNTIKLSSKDHVIIALKDINRGERLDLGEGAQLTVTDDVPKGHKIAAVAVSKGDDVLKFGYSIGKAKENILPGEWIHTHNLGTGLKGFLDYSYDPTFASGGLTDPSEEQAGGRFFQGYVRKNGEVGIRNEIWIINTVGCINKTCENIASRANRMFEGRVDGVLHFAHPFGCSQLGDDLRHTQKLLASLVQHPNAAGVLVVGLGCENNQIEVFQQAIGDYDSNRVKFLKSQAVEDELETGLELVGELVEYAESFKRVPVPASKLKLGLKCGGSDGLSGITANPLVGSVADRLIVQGGTAILTEVPEMFGAETILMNRAADEQVFGQIVDLVNDFKQYFIRHDQEIYENPSPGNKAGGISTLEEKSLGCTQKGGLSIVNDVKHYGERVVKNGLNLVEAPGNDLVSVTALTAAGAHIVLFTTGRGTPFGGPAPTVKISTNSELAERKKNWIDFNAGRLLEDRTMETLTDDLWDYLLKLASGEVRTNSEKNGFREIAIFKDGVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLE2</accession>
    <name>A0A398CLE2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03080">
        <property type="protein sequence ID" value="RIE03080"/>
        <property type="gene ID" value="D3H35_21090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="264" mass="30561" checksum="8087E7E8334C03ED" modified="2018-12-05" version="1">MGQGTILSANNGDGLSTVGRGTILSTNSGGACSTVGRGTILSTNSGADAQQWDEVPFFRRIAGAHAQQWDEVPFFRRIAGADAQQWDEVPFFRRLARTDSHQWDAVPFFRRITGTDSQQWDEVPFFRRIAGAHAQQWDAVPFFRRLARTDSQQWDEVPFFRRITGTDSQQWDEVPFFRRLARTDTHQWDAVPFFRRLARTDSHQWDAVPFFRRLVGTDAQQWDAVPFFRRLARTDSHQWDAVPFFRRLAGRTLNSGTRYHTFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLG2</accession>
    <name>A0A398CLG2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03503">
        <property type="protein sequence ID" value="RIE03503"/>
        <property type="gene ID" value="D3H35_12710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="226" mass="24414" checksum="FB35B135A9672AFD" modified="2018-12-05" version="1">MLATGGVEWPEEACRPAALNANGYAGIRFLLRLSLEGAQFMKELLVRDTWPVRAQAELELTGIAPRLPVKIAFDPPLLHRLLAELCDESGLVSEARLFNFFPRSAAAIGLTLDGEPAALASLRNVGRLGPFAIRLVCGGASRRWPRLFGIEPSERRLGEGGMGFIAADDDLADNRCFARTVRHGAPSCLLRGLETIVPPPVIVPPLTTGFHQVDISANIPEPGRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLH8</accession>
    <name>A0A398CLH8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04196">
        <property type="protein sequence ID" value="RIE04196"/>
        <property type="gene ID" value="D3H35_06135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="206" mass="22000" checksum="BBB3B4A22AAC44A1" modified="2018-12-05" version="1">MESPVKRTYTVPIMLIIITGLAILCVVLYSRLLIVQQGKTTDEGQRLAESYLVAALMAERLHAGSDGLLKAETTAQKLAAKQLLGEAGAAGAGESLNLYSKAATFPEKPDSEDEEVRRAVTALNAIIGTDGKLKGIGEHDGELTDEEKQTLTIVRDSASEMIQALQRFRTPTGEAGYRAMTVGGEWVTAANEAIRVMEAAAAKLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLI0</accession>
    <name>A0A398CLI0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flagellar hook-associated protein FlgL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">flgL</name>
        <name evidence="6" type="ORF">D3H35_14950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial flagellin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02059">
        <property type="protein sequence ID" value="RIE02059"/>
        <property type="gene ID" value="D3H35_14950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013384">
        <property type="entry name" value="Flagell_FlgL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00207">
        <property type="entry name" value="FLAGELLIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02550">
        <property type="entry name" value="flagell_flgL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellin_N" evidence="4">
        <location>
            <begin position="10"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="5">
        <location>
            <begin position="232"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="312" mass="34207" checksum="2AFFEEC0175E7A7B" modified="2018-12-05" version="1">MMGRVTQGTITSQLLRNINKNLSQSAGLQEKLSTGRNINRPSDDPVGITYALRYRSDLSINERFQSNVDSATSWLSFNDTMLSQVTDVLQRVKDLAVQGSNDTNPDVALNNIADEITQLKEQLVDIANSQFKGKYVFNGQFTDKLPYDPSGTAENVLTDTGKIDYIVNTGVQLTVNLSGNAVFGFPPASSGVAVAPPNSNEDDNVFHVLDQMITSLRSANTTGVSAQLGPLESRLNKVLTQRAEVGARINRVELMEARLKDLNLNLETLQSKTEDADLEDLIIRSKVNENVYQASLSVGSKIIQPTLVDFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLJ0</accession>
    <name>A0A398CLJ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_28160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000054">
        <property type="protein sequence ID" value="RIE00491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00491">
        <property type="protein sequence ID" value="RIE00491"/>
        <property type="gene ID" value="D3H35_28160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="70" mass="8240" checksum="A85BB1E759D3A3BB" modified="2018-12-05" version="1">MEIESIPNDTQYFQKLRTYIAAISFRTSLKSERLLSENLAKQAVWGHQSHASGIRHVRRVQQSCYRFPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLL2</accession>
    <name>A0A398CLL2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrH</name>
        <name evidence="8" type="ORF">D3H35_11545</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Allosterically activated by GTP. Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03315">
        <property type="protein sequence ID" value="RIE03315"/>
        <property type="gene ID" value="D3H35_11545"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="7"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in allosteric activation by GTP" evidence="6">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="135"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="242" mass="26138" checksum="87BDE56A4D028212" modified="2018-12-05" version="1">MERPFYKRVVLKVSGESLSGLNGYGIDATTILSIAEQIKEVVELGVEVAIVCGGGNIWRGIAGSQKGIDRATADYMGMLATVMNSLALQDALEQMNVPTRVQTSIAMQQIAEPYIRRRAIRHLEKGRVVIFAAGTGNPFFSTDTTAALRAAEIEAEVILMAKNKVDGVYSADPFKDASAEKYEQLTYLDVLNKNLGVMDSTASSLCMDNNIPLLVFAITEKGNIKRAVMGEKIGTIVKGSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLL3</accession>
    <name>A0A398CLL3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable tRNA sulfurtransferase</fullName>
            <ecNumber evidence="6">2.8.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sulfur carrier protein ThiS sulfurtransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thiamine biosynthesis protein ThiI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA 4-thiouridine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">thiI</name>
        <name evidence="9" type="ORF">D3H35_06310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24176"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:13337"/>
            <dbReference type="Rhea" id="RHEA-COMP:13338"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136798"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]</text>
            <dbReference type="Rhea" id="RHEA:43340"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12910"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.4" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04226">
        <property type="protein sequence ID" value="RIE04226"/>
        <property type="gene ID" value="D3H35_06310"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140741">
        <property type="term" value="F:tRNA U4 sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01712">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00021">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003720">
        <property type="entry name" value="tRNA_STrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00342">
        <property type="entry name" value="TIGR00342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="8">
        <location>
            <begin position="60"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="208"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="406" mass="45321" checksum="232E2B81640A1A58" modified="2018-12-05" version="1">MNEQLVMVRFGEVSIKGRNRNRFEERLVRQIKWALRAFAALTYDRTYGRLLVHLNGESYEPIAVKLRDVFGIGSFSPVFKVDHDLEAIREAALNAIRTIEPAPRTFKMIVKRAWKGFPHDTPQMNHLVGSHVLRNTPELKVDVRNPEAELKVDIQAEATYVYCKVEKASGGFPYGMNGKAVLLLSGGIDSPVAGWMAMRKGLEVEAVHFHSYPFTSEQAKEKVVALAQRLAYFGGKIKLHLVPFTDIQTSLAQTGHDSLIITLMRRSMLRIAERLAEKNGALAIVTGDSLGQVASQTLGSMNVIGRETSLPLLRPLIMMDKLEIIRIAEKIGTFQTSILPYEDCCTLFVPKSPATNPNLRIVRQVETALGDDLDRMIAEAVDGTETLTVTEIGRSDTTNIAEDKWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLX7</accession>
    <name>A0A398CLX7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_10155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03653">
        <property type="protein sequence ID" value="RIE03653"/>
        <property type="gene ID" value="D3H35_10155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005690">
        <property type="entry name" value="GerBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="501" mass="55749" checksum="667B4559C9977EAF" modified="2018-12-05" version="1">MKQWKDGRTPITGRYDEDVAALNRTMATNSDVHVREFDLGRLGIRAAVFFLDGLSDKELIEEQILLSLMAEWSGKPNSEIRSTNRLPLLETIRDQILPLSEMSEASLIEETMLKVLVGSTALIIDGVPTALLIGSIKGRTRTVEEPETEGLIRGPRVGFNETLSDNTALLRRHGENGSMAIVKFKVGLRAQKDLAVAYMEDIADPALVDEVKRRIAKINIDNLPESGYVEQLIEDNYLSPFPQAQSTERPDRVISSLMEGRVAILLDGTPFALLVPVTFSMLLQSPEDYYERWIVGSLVRLLRFFAVFISLFVPALYISFISFHPGLIPTKLAISIIKSREFVPFSALMEALIMEIAIEILREAGIRLPKPIGPAMGIVGGLIIGEAAVQAGIVSQILVIVVAVTAIATFTIPFYSAGLAFRYMRFVAMFCAALFGLYGVVLFFLFLSTHLVKLKSFGVPYASPSIPYRVSIWKDLLIRAPLRMMKKRPELLHPQDPIRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM47</accession>
    <name>A0A398CM47_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Polynucleotide phosphorylase</fullName>
            <shortName evidence="6">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">pnp</name>
        <name evidence="8" type="ORF">D3H35_11635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03332">
        <property type="protein sequence ID" value="RIE03332"/>
        <property type="gene ID" value="D3H35_11635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="621"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="705" mass="76694" checksum="D4F0CF547CD68CA9" modified="2018-12-05" version="1">MEHRVDMLLGGRPFALETGKLAKQANGAVVVRYGETVVLCTVTASPGPKDLDFFPLTVNYEEKMYAVGKIPGGFIKREGRPSEKAILSSRLTDRPIRPLFPEGFRNDVQIVNIVMSVDQDCSPQIAAMIGTSAALSISNVPFNGPIGGVIVGRIDGQFIVNPTVEQEEKSDLYVVVAGTRDAIMMVEAEANEVPEADMLEAIMFGHDEIKKIVDTIDSLVAVAGTPKMEVKLHAVDASVEADVNAYAKSRLVEAVRIQEKHARQEAIDAINDEAVQHFSDFYAETPEKLKDVKEVLYDIVKNEVRRLITHDKVRPDGRGLSEIRPISSEVSLLPRTHGSGLFTRGQTQALSICTLGALGDVQILDGIGLEESKRFMHHYNFPPFSVGEARPLRAPGRREIGHGALGERALLKVIPSEEEFPYAIRLVSEVLESNGSTSQASICASVLAMMDAGVPIKAPVAGVAMGLIKDGEHVSILTDIQGMEDHLGDMDFKVAGTAAGVTAIQMDIKIDGIDRAILAESLEQAREGRLHILGKMLETMQEPRKSLSPYAPKIITMKINPDKIRDVIGSGGKIINKIIEETGVKIDIEQDGSVYIASTDEAANQRAKAIIEGIVKEVVVGEVYTGTVKRIEKFGCFVEILPNKDGLVHISHVAHERIAKVEDVLNIGDVIEVKVTEIDNMGRINLSRKALLKKDSEQVPAQPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM62</accession>
    <name>A0A398CM62_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NlpC/P60 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_10820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03535">
        <property type="protein sequence ID" value="RIE03535"/>
        <property type="gene ID" value="D3H35_10820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017443668" evidence="2">
        <location>
            <begin position="34"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="35"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="158" mass="16567" checksum="31A16A75BA4844C2" modified="2018-12-05" version="1">MKKQLAKWALMSALVTTGWFGFAAIGGTPQASAATAESMELLANGKELVGTAYKFGAPTGITYAFDCSSFVKYVFEQSGLELPRTSVAQSKVGDPVAKAYLSVGDLVFFNTGGSGISHVAIYAGSGKILHASSSKGVTVSSMNTSYWTKAYVTARRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMA8</accession>
    <name>A0A398CMA8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bifunctional protein PyrR</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Pyrimidine operon regulatory protein</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">Uracil phosphoribosyltransferase</fullName>
                <shortName evidence="6">UPRTase</shortName>
                <ecNumber evidence="6">2.4.2.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">pyrR</name>
        <name evidence="8" type="ORF">D3H35_06635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer and homohexamer; in equilibrium.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04486">
        <property type="protein sequence ID" value="RIE04486"/>
        <property type="gene ID" value="D3H35_06635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01219">
        <property type="entry name" value="PyrR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023050">
        <property type="entry name" value="PyrR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="7">
        <location>
            <begin position="11"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PRPP-binding" evidence="6">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="190" mass="21369" checksum="425CF738D88CEE2A" modified="2018-12-05" version="1">MQEPRVIMDESAIRRALTRIAHEMVEKNKGIEGCILVGIRTRGVYLARRVAERILDIEGTPVPVGELDITRYRDDRPHGEGYRDSASEGIGGDLPCSIRDKRIILIDDVLYTGRTIRAALDALMDFGRPQSIQLAVLVDRGHRELPIRPDYVGKNVPTSRFEQIEVSLTEVDDSDCVTILHPREAEIQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMG2</accession>
    <name>A0A398CMG2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_12325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03440">
        <property type="protein sequence ID" value="RIE03440"/>
        <property type="gene ID" value="D3H35_12325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004705">
        <property type="entry name" value="Cation/H_exchanger_CPA1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00831">
        <property type="entry name" value="a_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 6" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="6"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="679" mass="74838" checksum="DAA34401C167DC84" modified="2018-12-05" version="1">METFLAVLILLGLIGVSNVLNRYVPFIPVPLIQIALGIVVAVLPSGVHLPLEPELFFVLFIAPLLYNDGKHTPRDELWKLRAPILLLAVGLVFITVFAVGYAIHGMIPTIPLPAAFGLAAILSPTDAVAVSALAGRIHLPKSMMRLLEGEALMNDASGLVAFKFAIAAAVTGVFSLPKASVSFVLISLGGLAIGAALAFLITWIRLLLRRSGMEDVTMHMLIQILTPFILYITAEELGMSGILAAVAGGIVHAIERDRTESPILNLKTVSDNTWSVILFILNGLVFVILGLQIPGVSRVILSDPAFDNFKVIGYAVAIFAMLIALRFGWLFAFTRTPRFFGGNEDKKPLGLKMLVMTSFSGVRGAVTLAGAFSIPLVVEGGGPFPERNLILFLAALVILLSLIAASVLLPLLAKKKGSEASAEAEQNEREIRIKVLKAAVQAVMLMKEEHEHKAAAASVIADYRKWIHEARTSGDSGRRPTRSRETETELRLLAIGAEREYVRNMLRDEEINREQAARLMKRLDQAELIVSNRTHLWKMTFKLLFRRIKAGLTPGRRSTDDKLSGNELETLRKAKIQTCQAAIREVNKIRCADNEEESYGIVTFYNEVVDRLSRTSLTTGRTDPAFLDAKKELRWTAIQAERDEVQSLFEKGEISREIAGDLRRMIRDREAAMFEQDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMK7</accession>
    <name>A0A398CMK7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03522">
        <property type="protein sequence ID" value="RIE03522"/>
        <property type="gene ID" value="D3H35_12120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="116" mass="13377" checksum="BA5A20E5E9EE1D6D" modified="2018-12-05" version="1">MNEQQQSVCLNRLHRVLDLFGGKWSFEVIAQLYNGSRRYHQLQQALESISSKALSDTLRRLESGGIVKRTVYATTPVTVEYSLTPQGFDFRRVISEMNDWAAKWLPNEEEVSSVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMM1</accession>
    <name>A0A398CMM1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copper amine oxidase N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_17485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02489">
        <property type="protein sequence ID" value="RIE02489"/>
        <property type="gene ID" value="D3H35_17485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017352532" evidence="1">
        <location>
            <begin position="31"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="2">
        <location>
            <begin position="333"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="2">
        <location>
            <begin position="363"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="456" mass="49928" checksum="CC0E2585AC564D1E" modified="2018-12-05" version="1">MKRVRKAIVMSVLLGAVIMNGFAGGSSALAADTGLQIKQFYYLDKELDRISLNTATKPDGTRDGHLSLLIDAGAGTEIKSITMKTADANGKDTNHGIWKTWKEASGDIGNMLAVVQDGKIVNTTFQPTLGSFKGVAQLELYASDNNGMKPGEYYYLEIATSDGIVKSAVTPYAENDLSYAPVVIREFGWVDLKSDQTGIAKFEADGTTDGHFKLKLNFTQPTEVLAVILRPTEENGKDAYKGIWRTNRAGTGWLLGMKQGETVVTPGFKKDVKEPVGKFRGNVAFDLYANNNGSIKDGQYFVIEVETKFGTVISKPVKFGDPNSIYVNDVVRNFKTIIMNIDSTAAFVDETKYTLDAAPFKQEGRTLVPIRFISEALGAKVGWNGAERKVTLEKDDVKIEIVIDRKEATVNGETVVLDAPAIIQNKITLLPVRFVSETMKMKVFFDNGEIVVTDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMW4</accession>
    <name>A0A398CMW4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01247">
        <property type="protein sequence ID" value="RIE01247"/>
        <property type="gene ID" value="D3H35_22925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="180" mass="20877" checksum="CDE88BFAC673530D" modified="2018-12-05" version="1">MQKYPLFIITGASGVGKTTVMHVLRDLMPEFVVFSTDYDNFGTTADKLEYQERYNLLLHFAHAVAKSGRGTIICGTMMPWDAQKCDAYNNFSEVCFINLHCDDATRNSRLRNREDKAMWTDDMLQQHEEFAQWLLDHADTHYNPPMPTIDTTFTPPSQVAEQIKRYVILKWNERTANTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN25</accession>
    <name>A0A398CN25_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spore gernimation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_18395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02649">
        <property type="protein sequence ID" value="RIE02649"/>
        <property type="gene ID" value="D3H35_18395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004761">
        <property type="entry name" value="Spore_GerAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34975">
        <property type="entry name" value="PTHR34975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03845">
        <property type="entry name" value="Spore_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00912">
        <property type="entry name" value="2A0309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="364" mass="40742" checksum="608CE24011887CC9" modified="2018-12-05" version="1">MKQDNGAISAMQMAFMMYPTVLASGFLALPTITAQYAFNDLWLTPIFASFAGFLTLFIALRLHKLYPGQTVIEYSVKIVGNIPGKLIGIVFFVYFIHETGVILRQYGDFVVGNFLFKTPILIVMSSTMLLSAIAVRGGAELLARSAMIFTPLFICPMLFLLMLIPDLDVQHLFPILERGLVPVLKGTLTPQAWACEYFIVTFFLPCLSNPYNGGKWGALSLTAVMISMLYVDFLVLFLLGPDTGNKVYPILTAFRYISLADFFENMEALLLAMWVVGNFIKIGVFFYASVISFTQCLNLSGYRFVVYPLAVWVVIFSIWDIPSFPHLAYYLEKLAEFEIPAVLTALPLVLLIVAAIRHKFQQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNB5</accession>
    <name>A0A398CNB5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_09620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03802">
        <property type="protein sequence ID" value="RIE03802"/>
        <property type="gene ID" value="D3H35_09620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="195"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="381" mass="42405" checksum="C7EBDBBB73F20A08" modified="2018-12-05" version="1">MKILLTIHHYLNPNAGAEGVTMQLAEAYRRLGHEAELFAYDHLPKKLPFHAKRLLFPYFVSRALRSAAAAYDIVDASSGDAWVWATAGGRGRRKGPTLVARSHGLEHLVHEVLVQRAKDGQHRLSWKYPIYHGGFRLWEVAQSFRKADGAVFLNQAEQSYGRDKFGMNFTAVIGNGIPAYLIGREIAQTPLEADSNVAIAVVGRYGTLKGSLDAAKALAPLMRSRANVTVTFLGTQCEASKVHEDYPAELHARIRVIPRYKHEELPELLKGHHIKLFATVKEGFGMALVEAMACGLAPVTTKIPGPSDIVTDGHDGFLLAPGDADGMYRALDKLVSDRPLLNRIRTEAYRTAQRYGWDDIARRTLAYYEECRDNKRRKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNF2</accession>
    <name>A0A398CNF2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">recQ</name>
        <name evidence="13" type="ORF">D3H35_08715</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04025">
        <property type="protein sequence ID" value="RIE04025"/>
        <property type="gene ID" value="D3H35_08715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006293">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01389">
        <property type="entry name" value="recQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="26"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="216"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="10">
        <location>
            <begin position="533"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE04025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="606" mass="67002" checksum="63DFD34BC4D9E4E6" modified="2018-12-05" version="1">MMEDALKALRTYFGYDSFRKGQTEMIESILSGRDALGVMPTGAGKSVCYQIPAVLFPGITLVVSPLISLMKDQVDALNESGIPATVLNSTLTGAEMNRRIRDISAGRYKLVYIAPERMESGRFAEWASDLNISFIAVDEAHCISQWGHDFRPSYLSIARLPELIEPRPIVAAFTATATPEVREDIVRRLKLDKPTRVTTGYARENLSFSVLRGVDKRSALASIIRGHAGDAGVVYASTRKEVDECQAFLVRQGIRAGKYHAGLEEEVRAEAQEAFLRDDIQVMVATNAFGMGIDKSNVRYVVHYNLPKNVEAYYQEAGRAGRDGDPGQCVLLYSPQDVVTQKFLIEQGEGDEERKMTSYKQLNDMVQYVYTSECLQQAIVSYFGDTCEPCGQCGNCLDTREKVDITEASKVVFACVSAMRQRFGVSMTAKVLKGAGDAKIRDYGFDRLPVYGRMNSRTEKDISGLIHALVAQGFLRLSDTAYPVVMLTSRVRQAIDDGERIYRRAEEPVPESSAKSSSGRRGSAAAGSVASLGAEGEALFAKLKALRKTIADRERVPPFVIFHDATLREMCVVRPATENAMRSVKGIGDAKYAKYGREFLEQIQNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNI3</accession>
    <name>A0A398CNI3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_19435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02809">
        <property type="protein sequence ID" value="RIE02809"/>
        <property type="gene ID" value="D3H35_19435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005690">
        <property type="entry name" value="GerBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="533" mass="58446" checksum="B9A8826261F90403" modified="2018-12-05" version="1">MRSQGRRARQNGTETTGQRGVPGGSGQLDSELETNLSRIRTELASSPDLIVRKFTLRTESRLPVAAVYLDSLTNKDNVNDFVIRSLLTPSLPEPPADAESPEEIFRYVCDNALAVAQFEIVGNWTTMLLELLTGKTILLVDGWAECISGNTIGGETRAVSEASTQVVIRGPKDSFTESVATNVALVRRRIRSPKFGFEAIKIGTITQTTVVMMYIEGIAKNSIVQEVRTRLGKIDTDAILESGYIEEFIEDNWFSPFPTIYNTERPDVVAANLIEGRIAILVDGTPFVLIAPTVLSQFFAAAEDYYQRYDIGSFIRLLRYMAFVISLFGPAIYIALTTFHQEMLPMALLINLTAAREGVPFPALIEAFAMELCFEILREAGIRMPRAVGQAVSIVGALVLGEAAVQAGIVSPIMVIVVAITAIANFSIPSYNLAITARMLRFLFMLAAGFLGFYGIVLGMIMLVAHINSLRSFGVAFLSPIVPFRFKQMKDIFIRTPHWTITERPDEVAADLVKTPPGEGPRTDTDGKGDGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNK5</accession>
    <name>A0A398CNK5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_22415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01161">
        <property type="protein sequence ID" value="RIE01161"/>
        <property type="gene ID" value="D3H35_22415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017224455" evidence="2">
        <location>
            <begin position="26"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="103" mass="10813" checksum="391E95F37355AA65" modified="2018-12-05" version="1">MLKRSVITSLVFTLVLVLAACGSGNNNEKQTPAPTATETPSASPSSAGVESAGDIEPEPGAKLLVWDGKDGVPFLKEIAKQFTAEYGIPVEVQEQGGPSSWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNM6</accession>
    <name>A0A398CNM6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage holin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04095">
        <property type="protein sequence ID" value="RIE04095"/>
        <property type="gene ID" value="D3H35_09130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="120" mass="12734" checksum="154D8883EB45EB20" modified="2018-12-05" version="1">MSFLGHVVRFIVSAIVLVIVGYIVPNFAVGGFWSALLLALVIAVLGWIIEGIFGRKVTPFGRGIVGFLASALVIWLAQFVVGGVHVSILGALLAALVIGIIDLFIPVANPFRAGTDRHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNN1</accession>
    <name>A0A398CNN1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmA</name>
        <name evidence="7" type="ORF">D3H35_27600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00514">
        <property type="protein sequence ID" value="RIE00514"/>
        <property type="gene ID" value="D3H35_27600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="103" mass="11017" checksum="3631A5D7B9042E9E" modified="2018-12-05" version="1">MLKLNLQLFASKKGVGSTKNGRDSQSKRLGVKRSDGQAVTAGSILVRQRGTKIHPGNNVGIGKDDTLFAKVEGVVKFERWGRDRKKVSVYPVAVAPVAAALEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNT7</accession>
    <name>A0A398CNT7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division protein DivIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_06510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04263">
        <property type="protein sequence ID" value="RIE04263"/>
        <property type="gene ID" value="D3H35_06510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013685">
        <property type="entry name" value="POTRA_FtsQ_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08478">
        <property type="entry name" value="POTRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="POTRA" evidence="7">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="211" mass="22942" checksum="994CF8FC3919FD41" modified="2018-12-05" version="1">MAKIQVINVEGASYLTAEEVKAALAVNVGDSFFVPSSGKLETRVRSLKPVKEASIVKHFPGKLTVKLQEFEEVATELGADGKVQAVLANGLVLPSKQGALPDKPILTGWKTGDANFQALCQTLSQLPDHLLTDLSEIKPDPSKSYPDRIKLYTRSRFEVVTTVGKLSEKIIFLSDIVENREPGRIVLLEADTYFPYSAQNADQDGADSANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNW3</accession>
    <name>A0A398CNW3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04042">
        <property type="protein sequence ID" value="RIE04042"/>
        <property type="gene ID" value="D3H35_08805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="215" mass="24432" checksum="CBF68F3CAE8B96F0" modified="2018-12-05" version="1">MRRVLLLTMLLLAFGGAGVYAHLTGAFSNYLLSIVDVDSTEQLRQEIDATKAQIESMKPRLAEQTARFAENRAAAAEQLLLLDSMGVDFRIGLLQQSGGPTELMADYWVLERYFRQYVQQLDELYRENAALSGEERKLRSYNLLLEKIEQGLEARNQFLASNADVHVEQLANYLDIDWTAEVEEELIGLLDRDRITVAEGADEWGQQGIRRRSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNY2</accession>
    <name>A0A398CNY2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04072">
        <property type="protein sequence ID" value="RIE04072"/>
        <property type="gene ID" value="D3H35_08995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014199">
        <property type="entry name" value="Spore_YtxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08812">
        <property type="entry name" value="YtxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="299" mass="33999" checksum="0DBD08795A4EDBB6" modified="2018-12-05" version="1">MGRHIVNYMLKRVGGNMKRVPYMSGLRQDPASLERLAAMLNRTTEHTKRPVDAVHWIVSGREGSIRCQFPIGPSPSAKKAACDKVARVLADYTLTDQEPSILRDIFQRKFGMKDELETDAIIAEAVSLLNGEPEPGDSCGGRGRDRRLRKLTLKYAGYLEDNERLNLDGFLRFRLGEYRAEVEEAAEAAMEERMMERQYQEFMTLLKAMVEWQDTRISAVHVMHSGGHAFRLLDEQMRPLEKETEPPEPRGEAEEESLLVSRLLAVSPRQLYIHTPEPESQVIRTLIGIFGERAALCTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP35</accession>
    <name>A0A398CP35_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CidA/LrgA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_08460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04132">
        <property type="protein sequence ID" value="RIE04132"/>
        <property type="gene ID" value="D3H35_08460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005538">
        <property type="entry name" value="LrgA/CidA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33931">
        <property type="entry name" value="PTHR33931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03788">
        <property type="entry name" value="LrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="118" mass="12852" checksum="36AC063350BF22E3" modified="2018-12-05" version="1">MRGLAILLSFNLVGVGLKEWLHIPMPGNVIGLVLFTIALFAKLVKLEWVEASAQWLTKHMMLFFIPYIVGAMALIPMLGAQLFPIALSVVLGPLLVVAAVGFVTAKLEKPSGREEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ11</accession>
    <name>A0A398CQ11_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molecular chaperone DnaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_06615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04280">
        <property type="protein sequence ID" value="RIE04280"/>
        <property type="gene ID" value="D3H35_06615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014240">
        <property type="entry name" value="YteA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02890">
        <property type="entry name" value="bacill_yteA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="5">
        <location>
            <begin position="53"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="245" mass="27660" checksum="3A165D1A8F4464A8" modified="2018-12-05" version="1">MTDPLTDERMQSLRNRLILERNELERRVGDNDRFGLAASFRDSTGELSGIDNHPADVGTELFERSKDIALLEKETFRLERVSAALSRMETGEYGRCAACGAFISYDRLDALPTAIYCLEHEPRQDVSERRPVEETFLSPPFGRTSLDDHDEPSGFDGEDAWQIVESWGNSDSPAMAEGSDCYDYSAIGIEADENDGFVEPLESFLATDITGNHVAVIRNREYRRYMASREGDPLLEPDELVDDYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ43</accession>
    <name>A0A398CQ43_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03419">
        <property type="protein sequence ID" value="RIE03419"/>
        <property type="gene ID" value="D3H35_12190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="195" mass="22281" checksum="6E25E41028995C93" modified="2018-12-05" version="1">MNTTIYMVRHAESPHIFGEERSRGLSEEGLEAAKKVAETMKNVEVHCVASSSYARAIQTVRYLAEANNLPIIEYDELIERPIMGLNYKAPWEQLFEAIKRSFTDIDYALEGGESTRAAGQRAIPVVQKLLQDYEGKNIVIGTHGNIMTIIMNYFDKSFGFEFWNGTSKPDIYRMTFVGDRLEKIDRVWESGQDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ88</accession>
    <name>A0A398CQ88_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sporulation transcriptional regulator SpoIIID</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">spoIIID</name>
        <name evidence="4" type="ORF">D3H35_14725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_027094289.1">
        <property type="nucleotide sequence ID" value="NZ_QXJM01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02017">
        <property type="protein sequence ID" value="RIE02017"/>
        <property type="gene ID" value="D3H35_14725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014208">
        <property type="entry name" value="Spore_III_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12116">
        <property type="entry name" value="SpoIIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02844">
        <property type="entry name" value="spore_III_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="95" mass="10967" checksum="C5DA25104980815C" modified="2018-12-05" version="1">MHDYIKERTIKIGRCIVETRNTVRTIAKEFGVSKSTVHKDLTERLPEINPDLADQVKHILEYHKSIRHLRGGEATKIKYKKTTVKKREVLTAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQF3</accession>
    <name>A0A398CQF3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase_H_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_04675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04775">
        <property type="protein sequence ID" value="RIE04775"/>
        <property type="gene ID" value="D3H35_04675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038720">
        <property type="entry name" value="YprB_RNase_H-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13482">
        <property type="entry name" value="RNase_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_H_2" evidence="3">
        <location>
            <begin position="148"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="498" mass="55830" checksum="1D54EC7AC5A60194" modified="2018-12-05" version="1">MSSLKERLERLKAAAKSAEQEARNEAAQSEEACDIGDGASGVRNVNVALEAGHASGDSGDKCSANHGSEGAAVLHPDFSDFGIEQVENEYGTFLLRRLEYRFPFRHGHYGLEQLADCAERLAPLARRQNKKNLKIGDPEVAVEPQGLLFLDTETTGLGVGAGNVPFMIGMGTYTECSFIVEQTLIRHPGEERAMLAFLAEKLKSRTHIASYNGKTFDWPLIEGRFIMNGWRPTGAGPGHLDFLHPARAIWRSTLPSCKLSVVEGARLGLAREEDVPGSMAPELYIRFLGDNDPRHLYGVFEHNEKDVLSLAALAIHFGHLLGGRLGSEAAWPEETEELYRVALWLESLGREAEAERLFGSLAERRWEEGSASFVWRMALAVRFKRAGALDRAIELWEEAARLAEKSRIPSWEAHVELAKHYEHRIKDFRIALFNAESALEIAHRRYSLMRETEAVRLIKTRLLHRCDRLRKRLERLREANETAEGVAHSSGRDMNLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQJ7</accession>
    <name>A0A398CQJ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PBP1A family penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_04590</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04762">
        <property type="protein sequence ID" value="RIE04762"/>
        <property type="gene ID" value="D3H35_04590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="10">
        <location>
            <begin position="79"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="9">
        <location>
            <begin position="347"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="728"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="728"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="793"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE04762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="812" mass="88399" checksum="CCF742E1492ADBDE" modified="2018-12-05" version="1">MNKPETNRKQRGSKGKSKRPKSRKRIGLIWLFFVVLVGVVCAVVGYLLVILNGERILSNNVNKLDLETATIIVDKSDKQIAKLSGEGSNREYVKFNDIPKKVTDAFVATEDKRFYEHGGVDLFGIGRALVKDIIARSAVEGASTITQQVAKNLFLNSDKTLFRKGTEASIALALENNYSKEQILELYLNRIYFGKNQYGIKTAAKYYFGVTDLNKLETWQIATLAGIPKAPNVYNPVNNPDKSMDRRAVVLSLMEDQGLITEQEKLAAAVVPFDPDKVPTKSSQYQTYIDYVFDEAQEVTGLSEDQFLRSGYTIKVSIDTKAQKAMEDAFAKESMFEKSKDETKMQGAMVIMDQHDGTLVAMVGGRDYSRQGWNRVTKQRQPGSSFKPIVSYGAAIETGNYFPWSTLRDDKTCYDKGKYCPTDSNRVKYVGPIAMTQAIKESRNQPAVWLLNEIGVSKGVSFAGKLGIELDKSDRNLAIALGGLTNGVTPLEMVTAYGAFANGGTLQNPHSVLEIKDKNNKTIYTYDPPKAKQVMAQETSYYVTQIMQGVTQTGGTGVKAKISGRPVAGKTGTTQLGIKGVSSSGNRDVWFVGYTPEWTAAVWMGYDKTDENHYVKQSSGQAAAMFAAVMSKGLEGKAKKSFPKPGNVQDEEKLPAVSGFTAAYVPEQVSIELKWGAVSAENVTYRVYRKADGEADFKLLAEVGLPLFDDLAILPEQTFTYYVTAYQASKKKESEPSPQATVTVTTDLSGEPSPGDNGQQSPPPNESEPPVEGGGGESPSPTPSPSPSASPSPGGEASPGSSPTPPVESAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQR3</accession>
    <name>A0A398CQR3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe/B12 periplasmic-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_05085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04842">
        <property type="protein sequence ID" value="RIE04842"/>
        <property type="gene ID" value="D3H35_05085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017253144" description="Fe/B12 periplasmic-binding domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="164"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="427" mass="47090" checksum="1D6D32BD9BA2DEA7" modified="2018-12-05" version="1">MNFSTKRLFGLFLAIALVFSIVPLSVAAAKSPITVKLDGKTVEFGVAPQSIGGRTFVPYRALAEKLKATVKWNEAAKKATIVKGSKTIELTIGSKTAKINGKSVTLDAAPVTKSGTTLVPLRFVGESLGLWVTWNAAASTANLESTRTIAHAMGTTKLDHVPERVVVLFNGMVDISVLLGVKPVGAVESYVQQPFYYYLRSSMTGVTVLGDETQPNLEAIVSLKPDIIITTKERHEKIYDQLNKIAPTIMTEKLANWQDNLKIASRIYNKETIADAFLADWKDRVADFKQKIGSRAKNTEVSLIRFNGGTTARAYQAGFAYNIFKELGFSFPKQQVATGKEFITVETLEQVSMLDGDVIFDFTTDWTEDGSITKNQSTWLASPLWKNLGAVKNKKYYKVNVVTWNMSGGAMAAKELLDDLYFYFDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQR4</accession>
    <name>A0A398CQR4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_23075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01274">
        <property type="protein sequence ID" value="RIE01274"/>
        <property type="gene ID" value="D3H35_23075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="338" mass="37173" checksum="28513EB6E9B4DFB4" modified="2018-12-05" version="1">MATNIRDVAKAAGVSVATVSKVLNGYTTVSQKTKERVLRIVKETRFQPNAAARALVGRRSMTLGIYLTTGLTHPFFASILSGMELALKAKGYDLIYLSQLTFNKDYSFVRHCQSRNVEGVVIFGFQEDDAYFKELLESGLPSIFIDMDIVGQRAGYISSDNVDAMCHSISYLRELKHRRIAFIAGIVESYVGRLRYDGYKKGLEIAGLPFREDYVAHSIFTRESGYSAMNSLLELPPAERPTAVVCCSDMCAIGAIDAIRDAGLSVPGDISVIGFDDIELARNVTPALTTIRQDMIAMGRKAVELLDELIVDEMFASPTAIVPTELIVRDTCAPAKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQV9</accession>
    <name>A0A398CQV9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000021">
        <property type="protein sequence ID" value="RIE04923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04923">
        <property type="protein sequence ID" value="RIE04923"/>
        <property type="gene ID" value="D3H35_03450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="189"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="287" mass="32422" checksum="18C416F346F7F097" modified="2018-12-05" version="1">MRSGYQPIQSPRFQRNLQHSGYKYREYAPSESLASHVACYWTMDFHAGDGNQVHRILPDGCVDIIIDLRSPSCRKAAFVAGLMAQYEVMTLTEAQSSFGIRFFIESAQTVLKFPVSAFIGSPIFLEDIWGEEGLFIVEEILAADTASEIVEIVERRLNLLFSCNVVSSSSLLHASMQYMYAFKGSISPSELAEKLSFSERHLRRIFDRELGMSPKEMLGIVRFQSMLQELHSGVHSSFTDIAMKYGYYDQSHFIKASSAITGCPKQLGKSTVEVRFLLYMTATERLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR63</accession>
    <name>A0A398CR63_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TlpA family protein disulfide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_14175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01921">
        <property type="protein sequence ID" value="RIE01921"/>
        <property type="gene ID" value="D3H35_14175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017357003" evidence="5">
        <location>
            <begin position="25"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="41"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="204" mass="22843" checksum="D89B8E4F3C214E5C" modified="2018-12-05" version="1">MGPCSCLAAGLIFLVLVPISVRQSNESVPRPIGPRPRGGRSSRNRLSRSILLPRAGIDGSLYKWRQFRGKPVVLNFWASWCGPCKDEAPSFVKLPRYVQERTDHHSHQPDGADSEKIRAGICRRIRILVPRSLDKDGSVAKALQDPPDPVHLLHRQRRLHRRRSACSLGAEDLKIRAEKLLRPDLSNEGRGVAKPGPSRLLPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR81</accession>
    <name>A0A398CR81_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03769">
        <property type="protein sequence ID" value="RIE03769"/>
        <property type="gene ID" value="D3H35_09455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014916">
        <property type="entry name" value="KapB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038080">
        <property type="entry name" value="KapB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08810">
        <property type="entry name" value="KapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01298">
        <property type="entry name" value="KapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141251">
        <property type="entry name" value="SSF141251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="123" mass="14116" checksum="18443DEDB2BB153A" modified="2018-12-05" version="1">MMTEASHVIFEHKTGRYIGEPLENDGRRVLVKILAVVGHPEQGDLHNPGDPDAPMFHERRALSYTEKVWIPAQAARPYAGTVPDYRQSLKAALEAEVEKLERSKRWTERSLTLLETLRSDYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRC4</accession>
    <name>A0A398CRC4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05082">
        <property type="protein sequence ID" value="RIE05082"/>
        <property type="gene ID" value="D3H35_02830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="292" mass="33123" checksum="66369A41F47013A0" modified="2018-12-05" version="1">MIKREFRYIELAGKLRTEILSGYLKPGQFLLPEKELCQVYDISRNSLRQALELLTNEGLLVKMVGRGTMVTKDLDIGKHESNIINIICPQHSSYVNKALPILIEMFKEQYPNVEFRLFGMGTNNEDLLQDLASFGVHADIVIMNDGDMQRLPLDKFLTLEDIVPEQGMTQDKLFQIFGHPTGQYAIPLTYSPVFLACNPHLFETSGLHIPQISWNWEQFVEAAKSITRDSNGDGNPGLNDIYGFGLSSSLYRWPVLARKHSYRMRQEPSGMLNTEGLAVFWTSSRRCSIGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRL9</accession>
    <name>A0A398CRL9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Formate/nitrite transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_12240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FNT transporter (TC 2.A.44) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03428">
        <property type="protein sequence ID" value="RIE03428"/>
        <property type="gene ID" value="D3H35_12240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024002">
        <property type="entry name" value="For/NO2_transpt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="PTHR30520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01006">
        <property type="entry name" value="FORMATE_NITRITE_TP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="260" mass="29250" checksum="09B0F76F838A59F6" modified="2018-12-05" version="1">MEIEALHQVEKLAEKKLAVFRQSFIRYIARSMLASMFIGFGVIVAFKTGNYFYTEHSPLTYPAAAITFGAAIILIFYGGGDLFTGNTFYFTFSALRKKMQWLTVLRLWLFTYIGNMLGACCFALLIYLTGLFEDSSVNGFLLSVVAHKMQTPTSELFFRGILCNWLVCLAFFVPMSMKQDGSKMFAMMLFVFCFFISGYEHSIANMCTFAIALVLNHPGTISVDGVLHNLIPVTLGNILGGSVFMGFMYYFVNKPLLDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS43</accession>
    <name>A0A398CS43_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04049">
        <property type="protein sequence ID" value="RIE04049"/>
        <property type="gene ID" value="D3H35_08850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="206" mass="24154" checksum="0E535442C225BD45" modified="2018-12-05" version="1">MKIAILSNGYSYHYRFYQMEEFRPLYDDVLNIRRLEEYDLLQYDTLIIPERMSLQLLKRYQSLFLKMLNAGKKLIVFGEVIDGWLPGVDWENSPVNFSWWVKENGDLPLSLDNMTHSLFRYIGMRDVKWHYHGTFGVPQGAFSLVNTPEGRSILYIDDVSYEGTLLVTSLDPMFHLGLGFIDQGKSFMYGFMAWLRKEGTEEGFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSB2</accession>
    <name>A0A398CSB2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_02925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05100">
        <property type="protein sequence ID" value="RIE05100"/>
        <property type="gene ID" value="D3H35_02925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017396505" evidence="2">
        <location>
            <begin position="29"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="442" mass="47707" checksum="A03D6175C024274C" modified="2018-12-05" version="1">MLKKRTSFTLLAVTVMIALLLQACGGNNGTSDSTSTPAATGSSSPKSSAPSGGEKVTLKVWGDLGNQAVLEEPFKKINAAFEAKYPNIKIKYDFAQNDQSLNVALQANELPDLFWVQGDKTSKMGEMVKNGFLLDLSSHNLDVSRNSDPEKSYCTVDGKLYCSLPSFFDTNVVYYNKDIFSKNGIDVPKNWDEFVQGLDKLKAAGVTPIALAGKSEWDRAWPIFAFAPAFANDALKAAQAGTGKLTSPAVAQTLQAFRDFADKGYFGKDFLAQDMAGAQFSFTNGKAAAIIDGTWNNATYTSSGINLGRFPVPNNDGKRVVQSSYSNFMTYAVSSRTKYPEEAVTYLNYLSGHEAQQIMEDATGLVPTIKDIQPKDEGVKELAVFDEAGLNIYSVLTALSTAQSNAADTFMKEVIPKLMTSEITGEQGAAILDKAAAYPAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSC5</accession>
    <name>A0A398CSC5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_16275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02281">
        <property type="protein sequence ID" value="RIE02281"/>
        <property type="gene ID" value="D3H35_16275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="70"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="270" mass="29937" checksum="D15A3E63343970D8" modified="2018-12-05" version="1">MTTSTSRKRSKTNKAARSAVRRFWIGAIVPAAVLAFWQLASANEWISPQLFPGPLSIFRDFYDLLVSGELANHLKISVYRAALGFLIGGSSALVIGMIVGLFSRAEQMLDPTIQMLRTVPLLAITPLFILWFGFGELSKVLLISVGAFFPLYVNTFLGVRNVDAKLFDVARVLEFSRFKQITKLVLPAALPNVLLGLRLSLSMAWLCLVVAELMGADRGIGFLIQDARSFMRTGVVFVGIFIFAAVGKLTDSLVRLMERRLLKWQDSYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSI2</accession>
    <name>A0A398CSI2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02757">
        <property type="protein sequence ID" value="RIE02757"/>
        <property type="gene ID" value="D3H35_19130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="151" mass="16060" checksum="FCAFE3843CC826CD" modified="2018-12-05" version="1">MNFDNWTSDAWLTFAQDHWVVIVVAVVAIFIVVNVVKTVVKWGLIAAIVVGIVVYGGYSVDDLKAVGADLTSKVSAELKDQAINAMAGEAKEATYTDNGDGTYTVKSSKLELTGKPGSGEVSVSFNGSTLGTWQLEGAVKQFVEQARKSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSP2</accession>
    <name>A0A398CSP2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP-N-acetylglucosamine--LPS N-acetylglucosamine transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_09450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03768">
        <property type="protein sequence ID" value="RIE03768"/>
        <property type="gene ID" value="D3H35_09450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009695">
        <property type="entry name" value="Diacylglyc_glucosyltr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06925">
        <property type="entry name" value="MGDG_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGDG_synth" evidence="6">
        <location>
            <begin position="17"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="5">
        <location>
            <begin position="205"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="371" mass="42099" checksum="D811CFED86AEA283" modified="2018-12-05" version="1">MRKKRVLLLSEGFGTGHTQAAYALSVGLRQLSPKIQTRVIELGTFLNPIIGPLILSAYRKTVSMQPKLVGKIYRNHYHKSLNRMKQFALHRLFYNHVSDVVRQLKPDCIVCTHPFPNAVVSRLKRLGLDVPLYTLITDYDAHATWTSPEVNTYLVSTPAVRNKLITRGVSASRIEVTGIPVHPNFWHPHDRAEILAQFELKDMPTVLIMGGGWGLLYGEQLVEYMTSYADRVQLILCMGNNEKAREKLLSDSRFRHPNVKVLGFTKEVSKLMDVSDLLVTKPGGMTCTEGMSKGMPMLFYEPIPGQEEENAEYFVTHGFGELMTSTDTIDRWFRLIQEPYAADQHRDTLLAIRNAEYHPAKCSEAVLELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSX4</accession>
    <name>A0A398CSX4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03858">
        <property type="protein sequence ID" value="RIE03858"/>
        <property type="gene ID" value="D3H35_09925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="68" mass="7802" checksum="381554CF1D0AB1EC" modified="2018-12-05" version="1">MHISWSDAFSDEIGRSSSDEFARKDGFINETELRCQDADRAALTPFERKIIPTNYRSALLEAIQRKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT23</accession>
    <name>A0A398CT23_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Efflux RND transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_01295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000012">
        <property type="protein sequence ID" value="RIE05310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05310">
        <property type="protein sequence ID" value="RIE05310"/>
        <property type="gene ID" value="D3H35_01295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="105" mass="11390" checksum="DEBB5411AC5A5BAC" modified="2018-12-05" version="1">MTIREALLEAAGTRMRPILMTAIATVCAMLPLVFGTSESGSIVSQSLAIVVIGGLIVATLLTLVIVPCIYELLFFRKSKRQRVAKASNKRSPLNRGSQEGLFRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT27</accession>
    <name>A0A398CT27_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Cell division ATP-binding protein FtsE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ftsE</name>
        <name evidence="8" type="ORF">D3H35_15250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Forms a membrane-associated complex with FtsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02114">
        <property type="protein sequence ID" value="RIE02114"/>
        <property type="gene ID" value="D3H35_15250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005286">
        <property type="entry name" value="Cell_div_FtsE_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02673">
        <property type="entry name" value="FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="228" mass="25831" checksum="5369AD360BA1F722" modified="2018-12-05" version="1">MIEMHDIWKTYPDGTVALQDINVVIDRNEFVYVVGPSGAGKSTFMKLIYREEVPTKGQLSVNGFNIGKLKHRKIPYVRRNIGVIFQDYRLLPKLSIYENVAFAMEVIEAPRRSIKRRTMEVLDLVGLKHKAQSLPAQLSGGEQQRVAIARAIVNNPAVIVADEPTGNLDPETSWGIMKLLEEINFRGTTIVMATHNREIVNSLRKRVIAIERGTIVRDQQRGDYGYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT50</accession>
    <name>A0A398CT50_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flotillin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_08210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03938">
        <property type="protein sequence ID" value="RIE03938"/>
        <property type="gene ID" value="D3H35_08210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031905">
        <property type="entry name" value="Flotillin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="PTHR13806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15975">
        <property type="entry name" value="Flot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="4">
        <location>
            <begin position="26"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="480" mass="52530" checksum="B6BA0D8A0EB9F29E" modified="2018-12-05" version="1">MELNSTLLIPVGIVIVVLVLIVVFASRYRTVKADEAMIITGALTKDGMKIVKAGGAFIWPVVQNASMLSLQVQTLEIPTPEVYTMHGVPVMVDGVAQIKIKGDQESIATAAEQFLGKPEEELKSIATQTMEGHLRAILGTMTVEDVYRNRDEFARNVQEVAASDLNKMGLQIVSFTIRDVRDKNGYLDALGQPQIAQVKRDAEIAKANAFRDETVAKSKAMEDGKKAEFNAETNIAEAHKAMEVKKAEFKKEQDLKKAEADQAYKLQEAKTLQSVKAEEMQIQVIEREKQIELESKEIERRERELVATVKKQADADRYAQEQRAEAERYQIEAKARAEAESVRLAGNANADKERAEGTAQADVIRLKGLAEAEAKDKIADALRKYGEAAVVELIIDKFPEIARAIAEPLSRTEKIVIVDGGGSGPNGGAGKVTGYVTDLLAKMPETVNALTGVDVNQLLKRLAEGSTAMKKDITPPVSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT73</accession>
    <name>A0A398CT73_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_20750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03027">
        <property type="protein sequence ID" value="RIE03027"/>
        <property type="gene ID" value="D3H35_20750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="191" mass="21396" checksum="5769EB0F8903EC7A" modified="2018-12-05" version="1">MYKVLIVDDEPLIREGLRSIIEWNEHGFEVTDTATDAYDALQKAPLLNPDLIIVDIRMPGMDGLTLMKTIQGQSSASPHFLILSGYADFDYARQALQLKADGYMLKPIDEDELIEQLGKIKKLMEEERSAKAAEWTRERIAQIVTAEEEADIPEGAAREAGMDWPAFDAVLIKLQSLSDIDSSVPRESRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT78</accession>
    <name>A0A398CT78_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SulP family inorganic anion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_08390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03968">
        <property type="protein sequence ID" value="RIE03968"/>
        <property type="gene ID" value="D3H35_08390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015116">
        <property type="term" value="F:sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfate_transp" evidence="2">
        <location>
            <begin position="29"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfate_transp" evidence="2">
        <location>
            <begin position="166"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="405" mass="43407" checksum="F038B3236E2C7B17" modified="2018-12-05" version="1">MHRVSLILSNGSVSELLQSIKRTWLFNVRGDMLAGITATLALIPDCIAFAFIAGVDPMVGFYSAICMLIILAFFGGRPAMLSSSAGSMAVLMTALVARHGVEYLFAATVLTGVLQWFMGVFKMGRWMKYIPRSVVVGFINALAILILVAQLRHFHGESWGMYAMVALTLAVIFLWPRLSKAIPSPLIAVALVTGVAFVVGWNGKTVGDIADIASGFPLFHMPDVPLNAETLLIIFPYAFSLALVGFIETLLTQDIVDEMTDTKTNKDREMKGQGIANAATGFFGGMAGCALIAESAINVKLGGRGRLSNLTAGVVLLLLVACFGSVLKAIPVAALVGVMLMVCFEIFDWKFLGQIRSLPILDTVVMLVTVVVSVVTDNLAFGVLAGVGLFAVSAVNRRRRPLTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTN0</accession>
    <name>A0A398CTN0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_20025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03217">
        <property type="protein sequence ID" value="RIE03217"/>
        <property type="gene ID" value="D3H35_20025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017415095" evidence="1">
        <location>
            <begin position="16"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="2">
        <location>
            <begin position="17"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="274" mass="28865" checksum="912595480C0B565A" modified="2018-12-05" version="1">MAVALLTSSVSSVGAASSLKGKIVVNGSSALLPLTLQAASEFKKLNPKVKISASAAGSVTGPQAVRKGIADIGACDWDASMDVPGFKKFEGQVATPIAVIPFAAIVNKNVNVSSLTNKQLADIFSGKVTNWKDVGGSDADIVVVNRAFGSGTRVNFQIKALLNGEFMSKGSNYKEVKSSGDMKTAVETTPNAIGYIDLVYVTGDKIKALKVNDVAATEANVINGTYKVWSYGYYMTKGQPTGATKAFIDYIKSSKFQNGSLKKLKFIPLSAMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU44</accession>
    <name>A0A398CU44_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chaperone protein HtpG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Heat shock protein HtpG</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">High temperature protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">htpG</name>
        <name evidence="6" type="ORF">D3H35_17455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Molecular chaperone. Has ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02484">
        <property type="protein sequence ID" value="RIE02484"/>
        <property type="gene ID" value="D3H35_17455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="SSF110942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="A; substrate-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="C" evidence="5">
        <location>
            <begin position="534"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="609" mass="69619" checksum="4D071AF5A430DFDE" modified="2018-12-05" version="1">MAKKQFKAESKRLLELMINSIYTQREIFVRELISNASDAIDKIYYKALSDDNLVFNKEDYYITVTADKDNRTLTISDTGIGMTKEDLENNLGIIAKSGSLAFKNENEAQDGHNIIGQFGVGFYSAFMVADRISVITKALGSDEAFKWESTGADGYTIAAGEKDSVGTDIILHIKENTEEDSYDEYLEEYRLKSIIKKYSDFIRFPIKMGEETVNSMVPIWRKNKNELTQEDYDNFYTDKRYGFDKPLKHIHISADGAAVYNAILYIPEQTPFDYYTKEYEKGLELYSNGVLIMDKCSDLLPDYFGFVKGMVDSADLSLNISREMLQHDRQLSLIAKNIKNKIKSQLLSLLKDEREKYDRFYKAFGRQLKYGVYSDYGTNKETLQDLLLFYSSTEKKLVTLDEYVSRMPEDQKFIYYASGESIARIEKLPQTELVADKGYEILYFTDDIDEFAIKMVMTYKEKPFKSVSSGDLGIEADASEEKSDAEESDNKELFEHMASALADKVSAVKASKRLKSHPVCLSTEGEVTIEMEKILKAMPDSQNIKADKVLEINVNHDVFQSLKDAYKNDKEKLSLYTSLLYHQALLIEGLPIQDPVEFTNDICKIMVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU99</accession>
    <name>A0A398CU99_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02841">
        <property type="protein sequence ID" value="RIE02841"/>
        <property type="gene ID" value="D3H35_19625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="133" mass="15481" checksum="BFB9B19CA40355B8" modified="2018-12-05" version="1">MLHGPLIKLESCPPIELDYLYGEADSMRLGKVLEEKRMQIVREALSGVKIAVLGRKYELHPETIRNWVREYGDKVGPDQLPSTDEQIQELKRLQEIEEKYNLALKKLGEKELENEILHELLKKKNPAYLKNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUT2</accession>
    <name>A0A398CUT2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_10570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000033">
        <property type="protein sequence ID" value="RIE03627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03627">
        <property type="protein sequence ID" value="RIE03627"/>
        <property type="gene ID" value="D3H35_10570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="551"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="603"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="625" mass="70678" checksum="3BF872946295C166" modified="2018-12-05" version="1" fragment="single">ILKELPLLSAAPRPGSRYSDHPIVSSDSDEYILAKLRLLNRYALDSLLDSTSIYGILDTLFLYPRKEQSIIFATQYNTNSEEKETTLNEWSRTHLTGPIEHDYRWESITVEGGYHYLLKAVDLDLNVYAGALVPSDSMMRVLSNFDVGPSGAALLLDSSGVSLTSRVFKPMEDPDFFDAVTRMNDSYKIVRSQGENYLVMAKHSQYADLNYVLITPESYILKSLPFFQKVLYIWIPLLVALLLSFYLLFLQRVVFKPLVELIRGMRKLGKAAGHSSADEPEQRIRVHVGIVQPDGRADRKAEDRRLRGAASGAEGGVQAFAGADQPAFLYEFLNIIYNLAALKDFKSVQKLSLHLADYFRFLMQSNRPVVSLEDEIRHIGHYLEIQKVRYVTKLDFEIDVKPEHLKAEISPLTIQPFVENSVIHAFNKRVQDGSLFRIAIRSEDGEDELGSYVVITVSDNGPGFPEDMLRDLGSDAYLAGTGEQHLGIWNILRRFRMLYGDAAESCSAMRTRGELSSKFGCPLPSSSRSAGMSRYCKKRRMIRKGGNVLLTMLVVDDEIYALKGITQGIDWSDLPISVILEAENVDQAKRKLQENKVDLVISDIEMRERTESSCFVISGKRLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUZ6</accession>
    <name>A0A398CUZ6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_13390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03121">
        <property type="protein sequence ID" value="RIE03121"/>
        <property type="gene ID" value="D3H35_13390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="104"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="159" mass="18394" checksum="A4F596E33D67469F" modified="2018-12-05" version="1">MASYGQEVWNLAYLLTRKHEMADDITQDVFLKAHANIRAFRGDSSIKTWLLTITRNLAINSLRTAFMRKVTLVAWVMPQGAGPSAEQEAMDNEWTSRVWLNVLKLPVKLREVLVLHAKYEMSTKDIAKMLQLSEGTVKSRLSRARSKMSEYRRESEEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV52</accession>
    <name>A0A398CV52_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_09440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03767">
        <property type="protein sequence ID" value="RIE03767"/>
        <property type="gene ID" value="D3H35_09440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="219"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="292" mass="31601" checksum="B027CF7A3C534348" modified="2018-12-05" version="1">MGTDVYGDIQKGERGAWISIGAYLVLSAFKLWAGWRYSSEALTADGFNNLTDIVASVAVLIGLRISRKPPDQDHPYGHLRAETIAALIASFIMATVGIQVLIEAVRSLWQGGVTEPNVSAGWVALIASAAMFLVYAYNVRLARRIRNRALHAAAQDNRSDALVSIGAAAGVFGSRLGLPWLDTVAAIGVGVLILKTAWDIFASATHALTDGFDVKQLMDLRSTVQHTDGVRQIKDIRARIHGSTVLADVIVTVDPNLSLAESHGISDAIEQSMRRKHNIMHVHVHVEPDEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV61</accession>
    <name>A0A398CV61_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose sorbosone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03151">
        <property type="protein sequence ID" value="RIE03151"/>
        <property type="gene ID" value="D3H35_16060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSDH" evidence="1">
        <location>
            <begin position="68"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="398" mass="42997" checksum="3EC53B372E85CECD" modified="2018-12-05" version="1">MTVMLLLGAMAIWTGCRDDKGDVPSEPLDSAIEQALPAVTLEEVAPKGAFDNPVGMTIDGGLSAGLANKAFVVEQPGRIRMLDLKQPDKTPETVLDLTDRVYADGNEQGLLGLAFDPKRPGVAYVNYTTKNATVISRFATADPEHPERLDPESELVLLTYEQPFSNHKGGQLAFGPEGYLYIASGDGGSGGDPYGNAQNTNSLLGKILRIDVLSGGAYGRSYGIPSDNPFANGGGAPEVYAYGLRNPWRFSFDAATGKLWAADVGQDRLEEIDVIEKGGNYGWNAMEASKCYEPASGCVKDGLILPIYEYGRELGVSITGGYVYRGKQLSEWIGWYIYADYATGTIWALRQRDDGTVDNRTLLQSGERITSFGVDADGELYICSQDGSLLRIAKRQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVB2</accession>
    <name>A0A398CVB2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cardiolipin synthase</fullName>
            <shortName evidence="12">CL synthase</shortName>
            <ecNumber evidence="12">2.7.8.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cls</name>
        <name evidence="14" type="ORF">D3H35_09800</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol</text>
            <dbReference type="Rhea" id="RHEA:31451"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phospholipase D family. Cardiolipin synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="12"/>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03837">
        <property type="protein sequence ID" value="RIE03837"/>
        <property type="gene ID" value="D3H35_09800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008808">
        <property type="term" value="F:cardiolipin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01916">
        <property type="entry name" value="Cardiolipin_synth_Cls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030874">
        <property type="entry name" value="Cardiolipin_synth_Firmi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022924">
        <property type="entry name" value="Cardiolipin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04265">
        <property type="entry name" value="bac_cardiolipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE03837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="475" mass="54886" checksum="A6BB92A5B01CC778" modified="2018-12-05" version="1">MTWIVLFLLVILFQAATILLLEFRRPAHATAWLFILFLFPLVGFILYYFLAHEYRRSRSVKRRGRMDERRRAIRLRKSTLLTRPSQLPDEKLSENGRLFRMLVKGGEFPITGANRTRLFNNGHDTYDAMLEAIRSAKHHIHMSSYIVRDDHMGRLFRDTLADKARQGVEVRFLFDGLGSYKLKAAYFKPLLEAGGRFACFFPIRISFLKKRLNYRNHRKILVVDGLKGFVGGINLGDEYVGKDRRLGYWRDTHLEIEGDAVYGLQEVFLKDWELATKERPSHPDYFPDHACEGREPVQIVSGGPNRRGDAIHDAVYALISSARERIWITTPYFIPSAAISMALHDAAMSGLDVRILIPSIPDTYLVHWATLSYVEELMKSGVRVWQYQKGFVHAKTIVIDKMAATVGTANMDLRSFFSNFELNAHLFDAEAISRVENHFLEDLQDSTEMRLQLFRERSKKQKTREALARLLSPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVI1</accession>
    <name>A0A398CVI1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldose 1-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_20680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03014">
        <property type="protein sequence ID" value="RIE03014"/>
        <property type="gene ID" value="D3H35_20680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="330" mass="37444" checksum="37A87334B381DEF0" modified="2018-12-05" version="1">MGHHEATEGKYENETAIFLKYGVYSAIMLPGIGGNLISFRDEERGYRFIREPEGAQWKEFVRFPVLHGIPVLFPPNRYDAGTFEFDGRTYRLPVNEPETGNHLHGFVYETPWEVVGFGSTERESFVTVRCRLDESHPAFEFFPHRVTLTQTYTLSSNGLTQAFEAVNEGSNALPFMLGFHTTLNVPFATGSSVEDVVIGIAIGERWELNERQLPTGRLFPLDEGETKLREGGNPFYTLLDNHYTADSAENGRNAAFLFDRKADVRFVYDAGREYKHWMVFNGKGSTSFICPEPQTGMVNAPNVDLPPERTGLVRLEPGERWSSVSRYYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX99</accession>
    <name>A0A398CX99_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05208">
        <property type="protein sequence ID" value="RIE05208"/>
        <property type="gene ID" value="D3H35_01420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1279" mass="145498" checksum="38EF505CE1BA54EF" modified="2018-12-05" version="1">MNFIKRLFNRKQISEERQINETINHNTHNGNQSIIARNITGSTIMQYYEGNRTSERIIDERISKELECLRRSRFYSDFDTARETLIFANSLLDGGLSSGSSVVRCHSLAWCSRLLSITEVDKAQELLNHAKALGSCPEINVAEAFITSKKGDKHAALTALASENSPLSRSAAIMIVVQHDGALGAIVWFEHAGYTILDLNSDGKYHLMTLYLQTSQWEKIESCLDKITVDDQNNSPALNQILGICHLVGAIPAEFRTSVLNQVPFHAARFPLAADSKALTGRRIACQYFITATNIAHDLKCHRSEALFSEYALWLQLMDPSEAANGREKLEVRLREPFSRLRIIHLGIQFGIKLDLEMVEREIERHIILHGGLTHDTAVARFALAFTKNNPEDVANYIMRHLKELSQHIDGKYMQILQIEMLAEASLPDRAKESFERLLEEGLTQAEENRLRRVISEIEGINPIEALKEQFKKTDSIVDLQLLIDQLEKLGSYEELSMYSELLYTRTSALSDAERLATTLHKLKKSEKVVELIAANRELLSQSKILHMLFCWSLYSEGSLIEARSEMQNCDEEYDDPNYRLLRVSLGITVGDWNSLAAFVAKEYQKKEKRTAKELISAAQLAHNLGSPEAKELTFSAVEKGSDDADILVKAYFLATKAGWEDDENVANWLNSASGLSDINGPIQSYSLKEMVDMKPNWDRRESEVLQLYGRGDIPMFFAADFLNKTLVQTMLIPAHINLVERDPRRIVSIPAYSGNRRQRILQLDGTIAFDVSALLTLNFLSLLDKVFDLFDTIYLPHSTLQWLFEEKQKISFHQPSRVTAARQIQHMLATGVIEKHIPKTSPDSELAVQIGDELALFITEAKLDNDNSYVVRPYPVHRISSLMEEEADLTKYDHVLSSCNAIVQILRRMGQITAEEERKATNYLKFHEKPWPNQPQIKMGAKLYLDDLALTYFHQIGILEKLRAAGFKLFVSSRELIEANNLVSYSNISDKIITAIESIRSVVNSRIESGKIKICRISLDENNVISEHPTAEIFNLATSCHSIIIDDRFFNKNEYVANGIQQMTIYSTLDILDTLVSINLITDEERMEHRTLLRRAGYFSIPVTDLELSNHLKASSVLGDKVLESAELKAIRENILQVRMRTWLQLPSESLWLDDFLSVFTTVLKEVWCTEEELPNIRARSNWIINQIDLLGWAHTLESEPAENLIKTGRGEFIFKLLVPPLGASKELKIEYWDWVEEVVLIPIKDNFPDLFLWLLDRYSELIATISNMYAQGGLLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXN6</accession>
    <name>A0A398CXN6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05288">
        <property type="protein sequence ID" value="RIE05288"/>
        <property type="gene ID" value="D3H35_01855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="79" mass="9092" checksum="BE881CE53C897785" modified="2018-12-05" version="1">MKLVKVTLHYADEANGIDETKDFLFKKGAQEAKWEFTYKDKSKQVYEWRASYFMVDGSVKNIEPGNTSEKTIVLPETPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXY7</accession>
    <name>A0A398CXY7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName evidence="4">PRAI</shortName>
            <ecNumber evidence="2 4">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trpF</name>
        <name evidence="6" type="ORF">D3H35_03980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TrpF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="2 4"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04657">
        <property type="protein sequence ID" value="RIE04657"/>
        <property type="gene ID" value="D3H35_03980"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="PTHR42894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PRAI" evidence="5">
        <location>
            <begin position="7"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="226" mass="24325" checksum="621F7E5474341B96" modified="2018-12-05" version="1">MSKKARVKICGIKEESTLRDMAELPVHYVGFMFVAASRRRVTAEQAAKLIAASRVVNMADGNPPLAVGVFVNPTINELRDVLAQAPLDVVQLHGDETPAFCREVRDTFGVDVWRALPVAEPGSSDADESGSERLEAYKGSVSTILIDTAGGGTGRTFRWDLIPSYQRIADRLGLKLIVAGGLSQDNVEELLALHTPYGVDISSGVETEGAKDSVKIAAFAERVNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY01</accession>
    <name>A0A398CY01_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03874">
        <property type="protein sequence ID" value="RIE03874"/>
        <property type="gene ID" value="D3H35_09805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="303" mass="33860" checksum="2362A8C7A80AD0F4" modified="2018-12-05" version="1">MPTAPNRTILRMGDYELAVSHPDKLLWPEAGITKLEYVQTLAKLAPYLLPYTTNRYLTTIRYPEGIHGTSFYQKNSPRPTPDYVRTAIAGDIRYVVLDSLPALMWMGSLYALEFHASCEEIGQLAPTPNVWMLDIDPTLPDEPRIMEAADHVLELLRSLGLQAVPKTSGATGVQIVMPIERGPTFDELRSFGKFCSEYLVAQHPGLFTVERMTKNRGELIYLDYLQHYSGRTLPAPYSPRARPGATVSTPLTWEEVRSGAKPADFHLRNIIERLQTRGDLIAAVPPQSLAPVLGGIASFLKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY85</accession>
    <name>A0A398CY85_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S41 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_04565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S41A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04757">
        <property type="protein sequence ID" value="RIE04757"/>
        <property type="gene ID" value="D3H35_04565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017397533" evidence="4">
        <location>
            <begin position="37"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="102"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="482" mass="51319" checksum="5E8DF9C8EB8E0349" modified="2018-12-05" version="1">MASGRKPTAAWRVWRIIFAFILTAAIAGTWFPAANASAETAEQVEEVRQLLEKYHLSNPDDNDLNQNAIQGMVESLKDPYTQYFDDDEWNEFSNQMEQKFTGIGIVMVEDNGVVYVEDTIPGSPAEKAGILPGDALVTADGKNLKGLSTTEMQAQLLGEEGTTLALGVSRDGKLLKFRVVRKDIQVPTATNKMLPDGIGYLSLTSFSSDAGSEFAKQLAILEKQGMSSLIIDLRGNGGGYVTAAQQIAGMFVEDGVLAHMKDRDNNDDPLTVKGTTKPYPVRILVNGHSASASELLSGALQDYGVAKLIGTTTYGKGVVQSIIPVSSGGVLKVTIQEYYTPTGRKVDKVGLKPDITIEGTAAEQLIGAIKDAGGKKITVSTGKGVVNVDGIRNAQTDAAISKNNGWYVNLRLGAALAGAKVSYNSKSHTISLTRNGKSYSITTTDASIVMKNGKSLIDVKKLQGWFPELTASASGGSLTLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYH4</accession>
    <name>A0A398CYH4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_08815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04044">
        <property type="protein sequence ID" value="RIE04044"/>
        <property type="gene ID" value="D3H35_08815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="215" mass="23591" checksum="75DB1C4BA00020FD" modified="2018-12-05" version="1">MIAIDGLNLNYGERIVLRNLCFRLGEGELVILQGRSGSGKSTLLKLLYREIPHFYGSILLDGTCIKTMPKHVIRRKLGVIFQSFELLERKTALENVALAGEVTGMPAKEIASRAEALLDRVGLTGQENSYPHELSGGEQQRVAIARALLNRPKILLADEPTGNLDGETAADMLSLLKTLQDETGMAMLLVTHADLLASMPEARLISMENGRIVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ86</accession>
    <name>A0A398CZ86_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_05460</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04541">
        <property type="protein sequence ID" value="RIE04541"/>
        <property type="gene ID" value="D3H35_05460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011623">
        <property type="entry name" value="7TMR_DISM_rcpt_extracell_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07695">
        <property type="entry name" value="7TMR-DISM_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="438"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="705"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="932"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE04541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1039" mass="115388" checksum="371D56FC71584509" modified="2018-12-05" version="1">MKSTRTLFLYAAVFFIVLVGIRVAWIVFEQPPAGYPSAVRGQLDLRGMGNFGNKTISLKGEWEFYPNRLLMQTTDRSYESGEGNGFIQVPGNWGSSLSPNSKSNLGYGSYRLKILVDRDDARQYGIRILGIAASSGLYVNGHFAAGSGRPAETKQQYKAVNSTYSATFSPVNGEIEIVIQAANFDNSQSGGIVKTVKFGTESAILKDERFSIAMQFLVFVVLAMHALYALIIYTVGTRQRVLLSFGLLVFSAMVMVLTDDDKLLQNWFSVSREWMIKLQFLSLVGVGFFILRFAKELIPEFMFVRAYRIMQTVNAVAATLLLFSSESFALSAGIGVFCILLLSISLFVALAIRMMLSGVENAVFLLCGAFAVQLSCIGGLVKSFGWFEAGFYPVDLLVAFLAAASFWFRRYIQAAAQTAVLSEKLQMEDKRKDDFLANVSHELRNPLHGILNIAQTVLESEQSVIGEKNAQKLELLMTVGRRMTFMLNDLLDLTLLKEQGIRLHLKSLQVQTVATGVIDMLRFMTEGKPIRFENRIPSTFPMVKADESRLIQILFNLLHNAVKYTNEGVITVRALSEGGKATFFVEDTGVGMTDGQQEKIFEPYEQVASGLTAVGNGIGLGLSICKQLVELHGGTINVYSVVGEGSSFFFTLELSGEQLEHEDTHVRTGRTDAEEDAQKLLAAADGEHRDPAWKPMFAAVGSGPKILIVDDDSVNRIVLSNILAAEGCEIATVSSGKEALAVLDSREWDLIIADVMMPIMSGYELTRIIRERFSVSELPILLLTARSRPEDVQTGFLSGANDHITKPMEAKELRSRVRALTELKHSVQDRLRMEAAWLQAQIKPHFLFNTLNSVAALGDFDTTRMRSLLDAFGRYLKASFDFRNSERLVPLDQELQLVRSYLYIEKERFQDRLHVRWEVDDNLRLSIPPLTIQPLVENAVRHGILRRSHGGEVRIRIACIEEGAEIAIFDDGVGMDPDTAKQLLEGRPVPGAGIGLRNADRRLKQIYGKGLRIMSRPGQGTTVSFLIRKTVSVSRLDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZB8</accession>
    <name>A0A398CZB8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division protein SepF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sepF</name>
        <name evidence="7" type="ORF">D3H35_06575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Localizes to the division site, in a FtsZ-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SepF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04274">
        <property type="protein sequence ID" value="RIE04274"/>
        <property type="gene ID" value="D3H35_06575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01197">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023052">
        <property type="entry name" value="Cell_div_SepF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35798">
        <property type="entry name" value="PTHR35798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0717">Septation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="148" mass="16828" checksum="AD1D1F1B7C2DA5F3" modified="2018-12-05" version="1">MGVMNKFLNYLGLQEEEVHERERPEAQEEQENETSPFEMRKNGTKSNVVSIHSQKSARVVLTEPRTYDEAQEIADQLKSRRSVVVNLQRIRREQAIRIVDFLSGTVYALGGHISKVGPDIFLCTPDSVEVSGTITEMMAEDADYPKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZR8</accession>
    <name>A0A398CZR8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Abasic site processing protein</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_07460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04414">
        <property type="protein sequence ID" value="RIE04414"/>
        <property type="gene ID" value="D3H35_07460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="PTHR13604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="SSF143081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="222" mass="25288" checksum="31396EE3C7DF2458" modified="2018-12-05" version="1">MCGRYTVTVTLEELMALYLAEGTALPFNLPRFNFAPTQLVPAIVNDGTRNRIGQLKWGLVPSWAEDEKVGIRMINARAESLDERPAFRTAYRRKRCLIPADGFYEWKTISGGKQPYRIKLRNGELFGMAGLYETWTSPDGRKVHTCTVITTTPNRLMEDIHHRMPVILRREDEALWLDRSIQDPSRLQPLLAPYPAEEMEAYPVSKRVGNVGNDDPDLVARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZZ5</accession>
    <name>A0A398CZZ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_04705</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04781">
        <property type="protein sequence ID" value="RIE04781"/>
        <property type="gene ID" value="D3H35_04705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="260" mass="29286" checksum="A8FA96596C1987D6" modified="2018-12-05" version="1">MIHLNSLTLRRGERDILRGVDLHVNAGEHWTLLGRNGCGKTTILEMITGYMFPTSGTVDVLGNRYGTVDVREVRKKIGYIGPTLIEKLTLRDPVWEIVVGGAFAYLRIYEKVEDELIEKAYEELDRVGLRSLAEQPFGTLSQGERKKVLLARTMMANPELLILDEPCAGLDLYEREKFLQALDSLADRKLSILYVTHHIEEIAPLFTHVALMTDGRITASGRKGEVLTPQLLESAYDLPIEVDWVDDRPWIRVGKGGASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D019</accession>
    <name>A0A398D019_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_05780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000026">
        <property type="protein sequence ID" value="RIE04514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04514">
        <property type="protein sequence ID" value="RIE04514"/>
        <property type="gene ID" value="D3H35_05780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="63" mass="7299" checksum="21E41367583AB461" modified="2018-12-05" version="1">MRWRSNSSAHKLTEQLGEQLSASVITNAKWEDKPRRAVEAKDTKWIKENVDVSRVLFRTSILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1C5</accession>
    <name>A0A398D1C5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000013">
        <property type="protein sequence ID" value="RIE05301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05301">
        <property type="protein sequence ID" value="RIE05301"/>
        <property type="gene ID" value="D3H35_01365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="156" mass="16543" checksum="E1B589C4E529B33C" modified="2018-12-05" version="1">MGIARNARSAQATPSCRKRSARFASCLRQAGARLACKTPPKPEACTPAVQRRRSGPGAALYPLGRGTFERWSIDIVGSIVALQQGSGPVYDDGASAPDGSIPVQDGLLKADDRCAMDWEYDRLTTATGMKILRLSVCGLVADRIDPASDLDHAVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D2H7</accession>
    <name>A0A398D2H7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spore gernimation protein KB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_01780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05274">
        <property type="protein sequence ID" value="RIE05274"/>
        <property type="gene ID" value="D3H35_01780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004761">
        <property type="entry name" value="Spore_GerAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34975">
        <property type="entry name" value="PTHR34975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03845">
        <property type="entry name" value="Spore_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00912">
        <property type="entry name" value="2A0309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="365" mass="39695" checksum="C162E36438BCB15E" modified="2018-12-05" version="1">MEKAKLGVSQLFALICLFEFGSAIVVGLGMQAKQDAWLAILIGMIGGMALFAVYNSLFRLHPEIPLTGYIPKIVGVWIGYPLSVAYILYFMYIAARVLRDLGALLLTSKLDRTPMSVINLMIILIVIYAIVLGIETLGRAGEFFLAVMILCLVAGAVSAFASGIIHPENLAPVLENGWKLVLTTAFPLTLTFPFGEMIVFTMLLPYLNQPARSAKTGMTALLSCGLILGFIRAVDISVLGLQKAGTSLFPLLETLSKVNIGNVIQRLDAIVIMILVIGGFFKIAVFTYAAALGISHTFKLRNRSLLAIFVGLAVWVASLFIARNVLEHLETGLSIVPFYLHLPLQAGIPVLLLVLAWIRTKMGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBT3</accession>
    <name>A0A398CBT3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000051">
        <property type="protein sequence ID" value="RIE00616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00616">
        <property type="protein sequence ID" value="RIE00616"/>
        <property type="gene ID" value="D3H35_27540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="124" mass="13327" checksum="FB773A422F61E80F" modified="2018-12-05" version="1">MPGPVQLARRDGRAAFTFIKYKPAAVTGGAKGGGFLMFEVNLRLDPALERRILSKLRSIAKDKPNLAVVPFDEGTVQCIALNLQGAGGALAQPAGRGRSTRSRKFSARPSIAARRQHRGIQPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBY0</accession>
    <name>A0A398CBY0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF4959 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_27275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00666">
        <property type="protein sequence ID" value="RIE00666"/>
        <property type="gene ID" value="D3H35_27275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032812">
        <property type="entry name" value="SbsA_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13205">
        <property type="entry name" value="Big_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="861"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="962"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="4">
        <location>
            <begin position="1212"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="4">
        <location>
            <begin position="1274"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="4">
        <location>
            <begin position="1340"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1048"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1048"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1402" mass="148193" checksum="5A6E6B67B80E7901" modified="2018-12-05" version="1">MKVNAPGGKTLTRTFIAQEGETVNLGGLSAGESGAFAGRPGNSVLLGTSNPAPGTMLRVSASYSNYLSTSLSGGVLVLDVPADAELVPGSVVWNGQPVTPALADGRYIVSLGTIGSRAIGSLQYLVRVADEPISESLDISPRIRYQSSGKPVEEEIGFARAAVARLTMTAPRRTAYRRFHVTGTAPAGSKAAVYAGDRVVGTAETAPNGRWSTSVEIDGEGHTAVWQLRAEASLGEQRWSSAWSSVQYDENTAEPIEFTLRQPDGRTIRLDPREGEIRFPYVFAPGLPFIATLKFNRPELARDVAFYIGETRVPASLKDGVFQAVINAVSPGAIGIDYSTRESGESIGGTPPPAAEIREQLPPAFRDARQEDLYISPREGGDRKQSMAYTGLLTGAKSDARVRVSAALERTTYAPNANDLALEKETGVPLYGFRMNQSFSDGVLRIELTGYLPADQFSAGLDAQKALALMSAGAQTHSYAELLSGVSGAAKKPAPVKALNAAIGVVAARVGLAFESAAGQNTWKAIDAAYSIYDGRGSGDTLTDLEYLMDKVSRYCDPYLVPAYLDHINFLKNHLIAVELTKAGIMVAGAVAGPATFGIGTIALFIASNAIGKVLDAQLAGWITKLNDDINQTCKVPKKPNKKIADPEWIYDPSGYVYEVTEDDRIEGVKATALRWNAAASQWEVWDSDWYGQENPLYTDADGRYAWDVPEGKWKVLYEKEGYLPAESEELTVLPPHFDVNIPMVSILPAKPVKVETAPGGSYIDILFDRPIKGDTVSGTLFAVVDPETNTDAAGVWTLVDPVSAGGGDASKRVRFTPSAALANGHTYTVIVDGAVQSYAGVPMGEVYETEVKITESDTIPPAPAVEMTTEADNNEALISWKLQGDPDLAKVVVVYKAQGAAGEGTAIEVPADRKFVLLEGLSGSTTYEIEVRTYDAAGNYSSAKATAVTGAQQQAQADITPPGPVVAAGAVTTGDTTVKVAWQDPADSDLSAVKLQWAKKGEAFALEPVAVTKGKGNYTVSGLLPSTAYEVRIWTVDIAGNSSPQQSLFVTTKAPSSGNPGSGNTGGEQQQPERDDSTENADLGEAGGELSFFEGKLKLRLPGSGSTAGTAKKVTVSKAGKGTAPTDSHLREVSEAYGWKLDTGGKPSSPIKLTMTYDAAQLKGADVRKLGLYRRDAADKGKWIYEGGVADGSAGTVSAEVTEPGVYAVLIAEYAFSDLTGHWSRSDVEALAARHIVSGRPDGTFRPNGKVTRAEFVKMLLPLISGGAESDSAVVAFSDVPQDAWFAEAVAQAAAAGIVQGSGGKFRPNDPVTREEMAVMLFRVLGADPEIKLNAATLLGEYQDGANVSGWARLQVAYVVQNGLLKGSGGKLNPGATATRAESAAVVLRTLDALGLVIQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCA9</accession>
    <name>A0A398CCA9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aliphatic sulfonate ABC transporter permease SsuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ssuC</name>
        <name evidence="7" type="ORF">D3H35_26840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00806">
        <property type="protein sequence ID" value="RIE00806"/>
        <property type="gene ID" value="D3H35_26840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="62"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="259" mass="28613" checksum="643B0B6671DDA4DE" modified="2018-12-05" version="1">MSRFKKILLSGWTPWFVPILVVAAWQLLGQYGYISTRLIPTPLKVAEAFISLSRSGVLLEYIWSSTKRAFTGFAIGGGIGFALGLLNGVFRIANNVLDSTLQMVRNIPHLALIPIVIIWFGIGEPAKIFLVALGVFFPIYLNTLHGIRSVDRGLIEMAKVYGLRGPSLYRHVILPGSVSSILVGVRFALGFMWLTLIVSETISADSGIGYMAMNAREFMQMEVVVLAIIMYAVLGKLSDLAAKGLERLLLQWHPNYANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCG4</accession>
    <name>A0A398CCG4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrH</name>
        <name evidence="8" type="ORF">D3H35_25935</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Allosterically activated by GTP. Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000044">
        <property type="protein sequence ID" value="RIE00876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00876">
        <property type="protein sequence ID" value="RIE00876"/>
        <property type="gene ID" value="D3H35_25935"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="7"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in allosteric activation by GTP" evidence="6">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="135"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="240" mass="25936" checksum="221A4D028212A242" modified="2018-12-05" version="1">MERPFYKRVVLKVSGESLSGLNGYGIDATTILSIAEQIKEVVELGVEVAIVCGGGNIWRGIAGSQKGIDRATADYMGMLATVMNSLALQDALEQMNVPTRVQTSIAMQQIAEPYIRRRAIRHLEKGRVVIFAAGTGNPFFSTDTTAALRAAEIEAEVILMAKNKVDGVYSADPFKDASAEKYEQLTYLDVLNKNLGVMDSTASSLCMDNNIPLLVFAITEKGNIKRAVMGEKIGTIVKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCR9</accession>
    <name>A0A398CCR9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000053">
        <property type="protein sequence ID" value="RIE00503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00503">
        <property type="protein sequence ID" value="RIE00503"/>
        <property type="gene ID" value="D3H35_28075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="201" mass="22856" checksum="AB9028CD1CCCE917" modified="2018-12-05" version="1">MLHSPVRPLNEQLSPHNSASRCRFSRRSLAKLVDQFEIDFTVETSRLRSSLSMTTNVVFNRSFRPLNTAREANKRLCREEFGLLRLEGSGDRLVKQRQTVDRLQKSLLQVGLVPRQHRFYTAVNASATGLPGQSRRSRSNSRSASLTASALPATPSLCKSMLGKPLLVCRRGERQARRRIRFTEKLLYGHCAFSRLFSIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD27</accession>
    <name>A0A398CD27_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000059">
        <property type="protein sequence ID" value="RIE00315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00315">
        <property type="protein sequence ID" value="RIE00315"/>
        <property type="gene ID" value="D3H35_29295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="155" mass="18458" checksum="BB20EA95A6483278" modified="2018-12-05" version="1">MIDQNSRMELLIKEFPSFQSDFSFLKFAENKVYENYLNFLQFLTQLIILVSIIKYLSETYIVFSILAVIVGALKGTINLITVNKRVLLNTEIETSLVKPMYYYNLLTGVDSQKEITLYSTTQYYKQKWANEREQIDSKKIRLEKMDKFTIWVRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD69</accession>
    <name>A0A398CD69_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Excisionase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_27195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00653">
        <property type="protein sequence ID" value="RIE00653"/>
        <property type="gene ID" value="D3H35_27195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012893">
        <property type="entry name" value="HipA-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07804">
        <property type="entry name" value="HipA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HipA_C" evidence="2">
        <location>
            <begin position="163"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="422" mass="47989" checksum="FEF8340B66B8B51E" modified="2018-12-05" version="1">MSEDRNKKYVLKHKHIQVAELELDEATGVIAAIGLVYDERHVPVGVPVKKGRIDRAALNEWWRGRSIPTSRDGIKEALIELNVPTTQKLLDKSLGLSLSDQYWISPEDVHADWMQLNFFDNAFSEDVGNILLGRDSSSGKELSLMSPDNTSDGWLKKKWTIMDGKRCLVKSGSGTVQQEPYNEVLASRLMDRLGIPHVTYSLLTQDEYPYSVCENFVTPQTELVTAWYVMHTRQKPNHVSVYQHYLDCCEMLGISGMTEALNRMIVVDFLIANEDRHQNNFGVIRNAETLEWLGAAPIYDSGSSLWFSKPSSLISASSKLTCKPFKNDHMEQIKLVTSFDWLDLSALHDIGDEFQAILEGSLFVDETRRKALCIALRSRVDMLAEIIRTRSLRVWVDDRSTDVRENIAYSGSQSKDDREPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDP3</accession>
    <name>A0A398CDP3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00833">
        <property type="protein sequence ID" value="RIE00833"/>
        <property type="gene ID" value="D3H35_27010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="138" mass="16213" checksum="BF5A4E262352C102" modified="2018-12-05" version="1">MKHIFLSRKGSQLIEIKKTLGRVVDYFPVLKTENTIGGLYTAITEMIGFKCMKKEKQWASPYGTNRFVEEFYRFYELNEEGGFVQNKKHFPLVARFCFGLYHQVKMRIKSSKQKRYCVLHFSIILSALCLMHAIIFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDQ7</accession>
    <name>A0A398CDQ7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_26625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00770">
        <property type="protein sequence ID" value="RIE00770"/>
        <property type="gene ID" value="D3H35_26625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="123" mass="14456" checksum="BDE28481F1799F34" modified="2018-12-05" version="1">MPEKADFNTVFSRLKEILTEYEAQLDVKNDTEREYYLDSFKINPINKKAVFFACVSIRKNYVSYYFMPVYACPKLLDEISAPLKKRMQGKSCFNFTKVDEELLLELKALTAKGYGYYKDENLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE33</accession>
    <name>A0A398CE33_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00695">
        <property type="protein sequence ID" value="RIE00695"/>
        <property type="gene ID" value="D3H35_26205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="150" mass="17605" checksum="DF0C68CE1A27055F" modified="2018-12-05" version="1">MHQDQLEYPVAQLIRDRRTVRQFREDPVPQLLITKLLDIACWAPNHGFREPWRFIQYRGEARRTFAESVVATFSAEEKEKNGDRRLAYYMDIPVHLIVVAKEDPRAKQREEDFAAVCCWIQNFSWRLGKEGSASSGKRIPICTLRLSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEP8</accession>
    <name>A0A398CEP8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminoglycoside N(3)-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_22035</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2-deoxystreptamine antibiotic + acetyl-CoA = an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12665"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57921"/>
            <dbReference type="ChEBI" id="CHEBI:77452"/>
            <dbReference type="EC" id="2.3.1.81"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the antibiotic N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.81" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01100">
        <property type="protein sequence ID" value="RIE01100"/>
        <property type="gene ID" value="D3H35_22035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046353">
        <property type="term" value="F:aminoglycoside 3-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003679">
        <property type="entry name" value="Amioglycoside_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028345">
        <property type="entry name" value="Antibiotic_NAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11104">
        <property type="entry name" value="PTHR11104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02522">
        <property type="entry name" value="Antibiotic_NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110710">
        <property type="entry name" value="SSF110710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="267" mass="30108" checksum="AC0B90B25A8B608C" modified="2018-12-05" version="1">MSEAQIKKAVLTKEDLIKQFRSCGVAEEQTIFVHTSLNSLGFVVGGAETLIRALLEIVGQEGTLLMPSQTWKNLDPSTGVHWDAPEDSWPIIRANWPAYNKEITPAIGMGVVAEMFRKWPGAKRTDHPARSIAAVGKHAEFITQEHDLSNIFGKNSPVDKLYQLDGHVLLIGVGYDKNTSLHLAETRADFPTKKFADESSAITVGGQREWVTYNTQAVDDEDFVRLGKDYDREHDIKVHRVGNADVRFLKQRPLVDWTVRWMEKNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEV1</accession>
    <name>A0A398CEV1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_28740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00402">
        <property type="protein sequence ID" value="RIE00402"/>
        <property type="gene ID" value="D3H35_28740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="303"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="584" mass="67344" checksum="AE5E7DB39600F1A2" modified="2018-12-05" version="1">MLHLQDIRRSSIRMKMLAGLFLIVIPLIGFIIYSNVYAIEVVRNQVAKSSKDLLSLYRDQLDARLKEVDNYLTGIMLDPDLSNLEFVSSPDQRLISKQQIYTNLSNAIFRYPLLDGLFVYIPSDDHFLYSFTSQSTMNDRMYMKSLISETVSQNRVSGNQKDWFIQKNGDQVYIVRYLMLNNTSIVGAWFNARSLQTPLDLLGIGEQGATLLGDDHGSAITDSEFIRENGVVIRPEASSYYLTGTKRRFIAVGERSHEGDFSLYAFIPENRILQHLPTLKMISYFLPFASIVILLLGLLFLRNSLLVPLNRLLKAMNRIKQGNLDMQIKQEATSMEFQMVNDTFNNMMEQIKNLRISVYEEQLNKQKAELQHLQLQIKPHFFINTLNMMHVMARMKDVVRMEEMSLCLIRYFRYMFQSNLSFVSLKEELQHVRNYLRIQEMRYPDLLKYEIQAPDFLMGTPVPPLVVHTLVENAIKHAVTLNDPVWIYIDLEMMEPPDSGLLIQVRDTGPGFREGVIQQVVNNQRIFDEEGEHIGIWNLKQRLKLLYEDQAVVVLKNLQPNGASVEITLPFSPSSRTNSSGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEY9</accession>
    <name>A0A398CEY9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2313 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01293">
        <property type="protein sequence ID" value="RIE01293"/>
        <property type="gene ID" value="D3H35_23195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018755">
        <property type="entry name" value="Phage_Mu_Gp48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10076">
        <property type="entry name" value="DUF2313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="194" mass="21989" checksum="983F399DDCC41B9A" modified="2018-12-05" version="1">MSDPLLSYLPEFYKDIGEFVELAATEDTELQSLQTAVNRLFNDQFVLTSSEDAIRRRERMLSIVADPTTETLSFRRTRIVNRYTTKPPFTKRYLQQKLDYIAGVPGLVVVEIDPVGFILRISVGIENAAVLREIEYTIHLLKPANLIYQPTTFAAERIGLHDQAYMIGLNRLTKLGSWGVGAIPFSVRRDAVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG89</accession>
    <name>A0A398CG89_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_16000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02236">
        <property type="protein sequence ID" value="RIE02236"/>
        <property type="gene ID" value="D3H35_16000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="332" mass="34881" checksum="97DC8620A791AEFB" modified="2018-12-05" version="1">MNVRTRNKRRRWLALAIVPALIATILFGVGSGSVSISFSEIVRVLFGEGNAVNESIIWDVRLPRVLVGLLTGACLAASGALLQGVMRNPLADPAIIGVSAGGGIGAVIALVLFPQFSLLLPGFAFAGAVVSSAFIYFLAWDNGSSPVKIVLAGIAVNAFLGGIMNGIMVLNSDRIQSVIPWLAGGLSGRSWPHLLFMLPYAAVGLALTPLAMKSANLLMLGDQSAQSLGQNVERHRFLIVALSSLLAGAAVSVAGLVGFVGLIVPHAFRLLIGEDYRYLLPFSIVGGAILMVAADTAARSWFDPLELPAGILLACVGAPFFLMLLKKRRLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGC5</accession>
    <name>A0A398CGC5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RidA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01783">
        <property type="protein sequence ID" value="RIE01783"/>
        <property type="gene ID" value="D3H35_13355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02199">
        <property type="entry name" value="YjgF_YER057c_UK114_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013813">
        <property type="entry name" value="Endoribo_LPSP/chorism_mut-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14588">
        <property type="entry name" value="YjgF_endoribonc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjgF_endoribonc" evidence="1">
        <location>
            <begin position="9"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="152" mass="16432" checksum="134551E0B287FCB0" modified="2018-12-05" version="1">MPKQTVAERLKTLGIVLPDASEPAARYANFVKVDKLLFLSGKGPAGNPKGKLGTDYTTEEGYQFARQAGIEVLAVLNSALGSLERVKRAVKIQGFVNASPDFEEHHKVLNGCSDLILDVFGEKGLHARSVLGAVSVRNNLPIIIDSIFEVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGS0</accession>
    <name>A0A398CGS0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MMPL family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_17000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02406">
        <property type="protein sequence ID" value="RIE02406"/>
        <property type="gene ID" value="D3H35_17000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="563"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="674"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="704"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="46"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="403"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="753" mass="82417" checksum="83C2BA57E11A398D" modified="2018-12-05" version="1">MFKALGSLAAKYPRIVVSIWIAILLGSVFLSPKLEQQLSISAFNNMNSESTDARADIKTQFNDQSPQKLILLVESGDIRPSDPAFKQYILSLENEMKNNPAVSTIESAFSSDNPALLIADTNAAIINVNMTSDDSTTMRYVEVIKRDIIPKLPDSNDFTVQITGAPGIAYDLNTIGKQNVTKVESIALPIVFLLLVLVFRSLVAAFIPLIIGIFTILVATAGSYLVAVNMPLYILITNIITMLGLGVAIDYALFVTQRFREELSIHSDKRVAAVNAIGTTGRSVFFAGITVAISLSSLLVPNSMLARSIAVGGILVTVVSLLLALTLLPAMLVLLGKKIDLLKIKLPNLKKQAANPNAFVKKLMTYPIRFLLIGIVLTGLFAPSVFDIEIHEPAGAYTELPKSSEARQAMEKIVDHAGVGNIFPIQVLIRNEDRTMYEKESLAELERISRSIGQLDHVENVISLTTVNSASAATTDQLYDLYIQRDGFPSDAQQQLQTLVSKDERASIVYVIPEASPGSPETRELVHRLRDDLSKLMSPGYTMDVTGDTAIGLDFDAQFIRNIPMILAISIFLTFVLLLITFRSVILPIKAIVLNLFVTVNTLGFLVLMFQYAHIPGTHEAALNINTPVIVFALLFGLSIDYQVMLVSRIKEHYDKSGNNEAAIVHGYSKTSGMINGAAAIMITVFGAFYFADLQIVREIGVGLALAIFIDAVIVRTIVVPTSMKLLGRLNWWFPKFRQGQKQAQLLGTTPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH07</accession>
    <name>A0A398CH07_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotidyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03495</name>
        <name evidence="1" type="ORF">D3H35_13170</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000021">
        <property type="protein sequence ID" value="RIE04929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01750">
        <property type="protein sequence ID" value="RIE01750"/>
        <property type="gene ID" value="D3H35_13170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04929">
        <property type="protein sequence ID" value="RIE04929"/>
        <property type="gene ID" value="D3H35_03495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009267">
        <property type="entry name" value="NTP_transf_6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39166">
        <property type="entry name" value="PTHR39166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06042">
        <property type="entry name" value="NTP_transf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="192" mass="22205" checksum="807F1180DEC1C466" modified="2018-12-05" version="1">MYGIQTEQDIMDLIKKDEWMMDLLRAVQSLSLPDCWVCAGFVRSKVWDALHGFEKRTPLQDVDVVYFDADNTDWMDEKNMEQSLRTIKPDVPWSVKNQARMHIRNGDSPYRSSTEAISKFTETATAVGVHLDSEDNLVLTAPSGIEDLIHLVVRPTQYIIDNVDAKGKAYEERVMKKKWEAQWYKLTIVHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH66</accession>
    <name>A0A398CH66_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01810">
        <property type="protein sequence ID" value="RIE01810"/>
        <property type="gene ID" value="D3H35_13530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="168" mass="19022" checksum="F28F4EFD65BE849F" modified="2018-12-05" version="1">MNRKTLLGPLFILLGVFMFMKGGRDFDVGTIFAYFWPTLFVIPVGVFFHWLYFSMLQRRGVGVLVPGGVLLTAGIVCQIAMLFDLWDVMWPGFIFAAAVGLFELYWFGGRNKWLWIPINVLTVVSLLFFAIFSVGKLLGSLFHGQPIFALALVVIGCLILFPRRKDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHA8</accession>
    <name>A0A398CHA8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_15420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02143">
        <property type="protein sequence ID" value="RIE02143"/>
        <property type="gene ID" value="D3H35_15420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="7">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="226" mass="25812" checksum="F7E6E91B208CAA2B" modified="2018-12-05" version="1">MRIHIIAVDDDPHIRELLRFVLSKEGYRVFEADNGEAASVVMENEQIHLAIVDVMMPGKDGLELCREIRTDYDIPVIMLTAKGAIEDKEKGFISGTDDYLVKPFDPKELLFRIKALLRRYRHVSSEAIKLGNVTIDRKSYEVTINGEPLILPLREFELLSQLAANPGRIYTREQLIQLIWGADFAGDSRTVDVHVKRLRDRFADRQEGFAITTIRGLGYKLEVKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIA9</accession>
    <name>A0A398CIA9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_25450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00919">
        <property type="protein sequence ID" value="RIE00919"/>
        <property type="gene ID" value="D3H35_25450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulase" evidence="3">
        <location>
            <begin position="80"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="469" mass="54251" checksum="B13598A86209F9B1" modified="2018-12-05" version="1">MIGMQRLIVKGNQIATSDGKEVKLRGANIGAWMNLENFLNGYPGSESALRNEFALRLGESGAAHFFERLLSGMFSEEDVVFLKACGMNVLRIPVNYRHFESDLQPFVYREEGFKLLDQALEWCEKHEMYAILDMHTAPGFQSPDWHSDNSSQRAYFWEHIQFQDRFITLWEHFAARYRGRAVIAGFDLLNEPVSNASYGRFPAQYRSDWDKINGVYRRAVEAIRAIDAERILILEGDYLGFYFEGFEAPFAEHLVYSSHLYPPPAVKEGHYPGVIDGEEWDKEKLRQAFFESEGAQFARKHNVPLLVGEFGALYIHPEELESRNRALGDMIEAFEDFGAHWTVWTFKDIGHMGLLQIDPSSEYARMIAPLLQVEYAFNRDDGWGRQQVAVMADRMKEAIEDAGIDRDLNRYFLEMSVRENYLQVLLLPSYVKLFEGQTPERIESILEAFREDRCLRHDSLGVVKRFLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIX5</accession>
    <name>A0A398CIX5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Daunorubicin ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02335">
        <property type="protein sequence ID" value="RIE02335"/>
        <property type="gene ID" value="D3H35_16590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="264" mass="30470" checksum="D343F06478FA0BD2" modified="2018-12-05" version="1">MASAYLELIRMRFLMMLAYRVNYYSGIIIYAINIGAYYFMWQAIYGNAETLAGFTVSQMTTYVAVSWMARAFYFNNLDREISNEIRDGSVAVQMTRPYNYLMVKMMQGFGEGIFRLGLFMIPGMIIVSLLFPVTLPTEPVRWIVFFVMIWFSFLINSQINIMTGLFAFFVENNEGLMRMKRVMVDLLSGVVVPISFFPLWAKPLLEWLPFQAITYLPSSVFTGRLSGADVWQALLVQVVWFLVLIVPILAMWRAARKRLFVQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIY6</accession>
    <name>A0A398CIY6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02693">
        <property type="protein sequence ID" value="RIE02693"/>
        <property type="gene ID" value="D3H35_18735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="SSF50985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="79" mass="8788" checksum="1DDB3BDF16ECBCBF" modified="2018-12-05" version="1">MGMGKQLGRPAWRRFGSREAVTREGSGDQRGRLYIGGLLPYACLKEDGTVWTWGQNNAGQLGNGDKTMASARRPCKRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIZ4</accession>
    <name>A0A398CIZ4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translational regulator CsrA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">csrA</name>
        <name evidence="3" type="ORF">D3H35_14965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CsrA/RsmA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02062">
        <property type="protein sequence ID" value="RIE02062"/>
        <property type="gene ID" value="D3H35_14965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902208">
        <property type="term" value="P:regulation of bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00167">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003751">
        <property type="entry name" value="CsrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036107">
        <property type="entry name" value="CsrA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34984">
        <property type="entry name" value="PTHR34984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02599">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117130">
        <property type="entry name" value="SSF117130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00202">
        <property type="entry name" value="csrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="76" mass="8393" checksum="1F1BE98367E23F70" modified="2018-12-05" version="1">MLILTRKEGQSIIINNNIEILISSIDGEQVKIGINAPQEVHILRKEVYDAVQLSNKAAVSAKIDTSTLKKLPNPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ21</accession>
    <name>A0A398CJ21_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine kinase</fullName>
            <ecNumber evidence="1">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_22755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01219">
        <property type="protein sequence ID" value="RIE01219"/>
        <property type="gene ID" value="D3H35_22755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="670"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="851" mass="96987" checksum="F61DDB36088EC4D7" modified="2018-12-05" version="1">MREGFGLPWNILPLKYPFVRFAAAMVTGTMEAPQDCRGILRRISPMTDERLRAAMSVLDYASHASFVLDKNGWFSSILMMLELTITYGMTPEASVGFVGYAMVLNFKLHRQEAAYRWGKLACKVSKPNSRLHALAVTSFSVCYDSWRRYEPDFLPISADYVSKSALQSGDLWSANQSMLVNCALLFQFSHPLKDIYRRLLDYFPHLQRNNNILHGKQAAVLARMILDLTGYQEADDPYAEIDIQSKSFVEEVPGDDDHFLQESVYIYQYVTGYFFGQYEKAYFALEGCMRLAESRSEPLLDSSSHDYYRVLVLKERYAARTKREQAEDWLHIRRCLKRLKTMARRSPEHCLHKYLLAKAEAASLRHQDRQAETLYEQAWDTARANGYFHDAGAAAECYAKHGIARGKTRLAKLYMNEAYESYRKWGALAKTADMETKYGHLLNLKRETETDMERIDYLSVVMSAQALSGEMEMDKLLRMLMRIMLQNAGAEYGALIFEDDDGWKVEAYGTSEELSIQSIPLEQAQHLVPAAIISYTARTNEEVVLHDAAASGLFERNDYIKHKELKSVLCLPIMNQNKLICLLYLENNLSSGVFTEKRLDVLKLLSSQCAISIANAKLYSGIQFLKSSLEDQVAERTSALEKSMQATSEALAETTVYAERTRIAQEIHDIVGHTLTSTILQIEAGRRLLHKDMDSAVVRLKEAQDLVRHSLSEIRNSVHMLKEDKYYDIEASLRQLIQDTERNAGVVVHASIEPVPLMSFMHKKVIYHALQEGLTNGIRHGNSNEFYFRLEDDGSQVQFSLADNGRGASRIAMGFGLNMMRDRVQQLRGTLQIDSEPNKGSLLRIQLPHYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ41</accession>
    <name>A0A398CJ41_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02340">
        <property type="protein sequence ID" value="RIE02340"/>
        <property type="gene ID" value="D3H35_16620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="94" mass="10091" checksum="6B28E7702633747D" modified="2018-12-05" version="1">MGYSGGELAHGGINRLGLGYWIGGRAHGGNNQLRLGYSGGERAHEGNNRLRLATRAANVRMEEITSSGWATRAADVSMKEITGYGWLLGRRTCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ62</accession>
    <name>A0A398CJ62_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02783">
        <property type="protein sequence ID" value="RIE02783"/>
        <property type="gene ID" value="D3H35_19295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009928">
        <property type="entry name" value="DnaI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07319">
        <property type="entry name" value="DnaI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="165"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="316" mass="36474" checksum="7B50EAFA35C4DD09" modified="2018-12-05" version="1">MESLGEAMRRLSVMQSMVDGERTAARVLADPLVVKLRERYPGLDEHVLHLNLNRLYQMSKEYRNCRECPGLERCPNDMQGHSTTITCAEAGGRWQIIDHKTPCAKFTADEQQRQLRRRITSFYVDEAMFGAHFDETEMDALDDDRFIAVHQIFDYVNKTTIEGLQNNGLFLMGNFGTGKTYLAGYLLHKLAKEGYSGVIVYMPEFVEDAKALMLEPQKLKETISLMKETDLLVFDDIGAENLSPWVRDHVLGPILNYRMNRKPTFYTSNHDLDALERHFSFTHKEGEEVHKGQRLMDRIRPFVDVVHVRGRNQRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJC8</accession>
    <name>A0A398CJC8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome c oxidase assembly factor CtaG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ctaG</name>
        <name evidence="8" type="ORF">D3H35_15975</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02232">
        <property type="protein sequence ID" value="RIE02232"/>
        <property type="gene ID" value="D3H35_15975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014108">
        <property type="entry name" value="Caa3-assmbl_CtaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019108">
        <property type="entry name" value="Caa3_assmbl_CtaG-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09678">
        <property type="entry name" value="Caa3_CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02737">
        <property type="entry name" value="caa3_CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="302" mass="34748" checksum="1DD38D8E6793AD1C" modified="2018-12-05" version="1">MWGLEYFSFRDLWSPLFMAFMMAVAILYTFAVGPWREKFAGSEDVPFKRQFSFLLAIFLLYMTQGGPLSLLGHLMFSFHMTNMAISYVIVPPLLLYGIPAWLWRWMFGRAFWRPLRFLMNPLVGLFMFNLVFSVYHMPGNHDYIMTHYSVHTAYYVLLLISAMIMWWHIHCPVPEWARLTPLWRLGYIFVNGLLLTPACVLIIFANTSLFSVYNDPEVWTKAMGYCVSGDPAALLAKFEGGPAFFNLLSPRDDQQLGGIIMKLVQEFVNVGALFVVFMGWYRSERAKEDDVSGSEATVAPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJE5</accession>
    <name>A0A398CJE5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arsenical pump membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_12365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in arsenical resistance. Thought to form the channel of an arsenite pump.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ArsB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03446">
        <property type="protein sequence ID" value="RIE03446"/>
        <property type="gene ID" value="D3H35_12365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01118">
        <property type="entry name" value="ArsB_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02040">
        <property type="entry name" value="ArsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00935">
        <property type="entry name" value="2a45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="430" mass="46307" checksum="A530078A64425733" modified="2018-12-05" version="1">MAVVASALFVITLVFVIWQPKGLNIGWSACGGAVIALIIGVVDIGDVWDVTLIVWNATLAFVAVILISLMMDEIGFFEWAALQVARLARGNGTLLFVYVVLLGAAVAALFANDGAALILTPIVLAMVRALKFEDRMILPFVMACGFISDTASLPLVVSNLVNIVSSDFFGIGFAQYAHRMLVPALFAIASSLLVLILFYRRSIPKRYDLAQLKQPKNAIKDIRLFRITWVILVILLAAYMTSGLLEVPVSIIAGAAAIAFLSLARRNREIRTWNVVKGAPWAVVVFSIGMYVVVYGLRNAGMTDKLGDLFAWVGEQGLFVATIGSGFIAAVLSSVMNNMPTVMINALAIEGTNSSGALHEAFVYANVIGSDLGPKITPIGSLATLLWLHVLSRKGVKITWGAYFRTGIILVIPVLFVTLAALYLWLTVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJF6</accession>
    <name>A0A398CJF6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02485">
        <property type="protein sequence ID" value="RIE02485"/>
        <property type="gene ID" value="D3H35_17460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="210" mass="26078" checksum="DAB534C721816D59" modified="2018-12-05" version="1">MRSRAQQWDEVPYIRRVVRSRAQQWDEVPYIRRKVRSRAQQWDEVPYIRRKVRSRAQQWDEVPYIRRKVRSRAQQWDEVPYIRRKVRSRAQQWDEVPYIRLKVRSRAQQWDEVPYIRRKVRSRAQQWDEVPYIRRKVRSRAQQWDEVPYIRRKVRSRAQQWDEVPYIRLKVLSRAHGLSHKRAYGTASSSLRAMLKKGWNDIGMFAYVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJH0</accession>
    <name>A0A398CJH0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02843">
        <property type="protein sequence ID" value="RIE02843"/>
        <property type="gene ID" value="D3H35_19635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="101" mass="11271" checksum="9E57EB94CF300DD7" modified="2018-12-05" version="1">MTAVSEEGRHQAKLETECKVAGRSCQQRKGWELEVTAVSEEGRNQAKLETECKVTGMSCQQSEGWELEVTAVSEEGRHEAKLKTEMQGYRDIMPAKRVLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJK4</accession>
    <name>A0A398CJK4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="2">RPPK</shortName>
            <ecNumber evidence="2">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="2">P-Rib-PP synthase</shortName>
            <shortName evidence="2">PRPP synthase</shortName>
            <shortName evidence="2">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">prs</name>
        <name evidence="4" type="ORF">D3H35_21440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01018">
        <property type="protein sequence ID" value="RIE01018"/>
        <property type="gene ID" value="D3H35_21440"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="3">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribose-5-phosphate binding" evidence="2">
        <location>
            <begin position="224"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="98"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="316" mass="34616" checksum="38EC20EF2F3697DE" modified="2018-12-05" version="1">MDSSKLRIFSGSSNPKLAEKMADQLGLPLGKIKLSRFKSGEVYVHYEETIRNCDVFIVQSLSHPINDYFVELLIMIDAAKRASARTINIVLPYYGYARQERKAAPREPISAKMVADVLTTVGANRIITIDLHANAIQGFFNIPVDHLTALDLISDYLKAKNIRNPVVVSPDAGRASTAEKLANQLDCSFAIMIKKRPAHNESVITHVIGDVEGCTPIIIEDMIDTGSTIVNVVEGLKERGAEDVYVCATHPLFSANALQKLDHPSIKEVVVTDSILLPDDRSTRFQTISVAPMLAEAIRIIMEGGSISTLFKDAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJL0</accession>
    <name>A0A398CJL0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03506">
        <property type="protein sequence ID" value="RIE03506"/>
        <property type="gene ID" value="D3H35_12725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="85" mass="9631" checksum="E99D8FA7D2D8B974" modified="2018-12-05" version="1">MLPPQPSADNRENQLFTGSQPFDREDGVPELECGFISIGGQLNPRRSMRSGLSIEFRSETRYPPLRIERMPAIRTSRLPNLSFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJR1</accession>
    <name>A0A398CJR1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02550">
        <property type="protein sequence ID" value="RIE02550"/>
        <property type="gene ID" value="D3H35_17830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="125" mass="13816" checksum="28A4A431B2BE7FB4" modified="2018-12-05" version="1">MAASELHVRQQRQYDRQVVGDYEEDRPGERADANVWHFYLRSDNTNSRIAPVVGSVARYEYDGFNQLVKVSSGSGGSTYEYNGDGLRVKKTTASGTTAYLYEYDKVVLETDGAGKQTAATCTALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJX4</accession>
    <name>A0A398CJX4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01158">
        <property type="protein sequence ID" value="RIE01158"/>
        <property type="gene ID" value="D3H35_22390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="136" mass="15927" checksum="9627286AAA5B791E" modified="2018-12-05" version="1">MRIEYATESDYPYILARDKHLLESLILPKIRSNEIVILRNSGGENIGWMRHGYFWDNTPFMNMLWIDEEYRNNGIGKRVVLNWESEMKKQGSSLVMTSTLANEGAQHFYRKLGYKDAGCLLLENEPLEILLTKRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK19</accession>
    <name>A0A398CK19_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycerol kinase GlpK</fullName>
            <ecNumber evidence="4">2.7.1.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">glpK</name>
        <name evidence="4" type="ORF">D3H35_10170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03656">
        <property type="protein sequence ID" value="RIE03656"/>
        <property type="gene ID" value="D3H35_10170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="8"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="261"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="501" mass="54911" checksum="F8E8329DA0DFF2B5" modified="2018-12-05" version="1">MSGGDRFLLTVDQSTAGTKAVLTDADGRIRHRHGVPHRQIYPRDGWVEHDPIELYDNVKTVIRDVMEKANVGEESIIGVTITNQRETAVVWNRRTGLPVANAIVWQCRRTADFCDKLRREGHEPLIREKTGLLLDPYFSAAKWRWLLDNREDGASDDELLAGTIDSWLIWKLTGGRVHATDYTNASRTQLFNIHTLQWDEELAELFGVPISMLPDVYPSDRIYGCIEDVGLFASPMPIAGVIGDSQAALFGQQCLRPGMAKGTYGTGTSVLMHVGDKPAAAGGGLVSAIAWGAFGRVEYAVEAIIHSTGDCLNWARDQMGLFQSYDELNRDIAEAGDTGGVYLVPAFVGLGAPHWNPRARAAIIGMNRSTGRRHLLRAAVESIAYQVADAVRLLERETGIPVGELRVDGGASANELLMQFQADLLNAEVVCSEAAELSALGSAFMGGLALGVWDSAAELNRFYRSRRIYRPEMNADERARLDRGWQAAVKGVLAAEDHLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK29</accession>
    <name>A0A398CK29_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_24680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01549">
        <property type="protein sequence ID" value="RIE01549"/>
        <property type="gene ID" value="D3H35_24680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="325"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="357"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="524" mass="59738" checksum="323E8B9D4B3443B3" modified="2018-12-05" version="1">MSVIRLENVTKKYEESMIFRDIYFRVMQGERIGLIGRNGAGKSTVFKLIMGKEEPTSGRVEIDPQVRIGYFSQFSELSGGLSVQQELEACFKQVALIERELQEVGDKLGVVADDSEMDALLARQAELFEQMDHLDGWNVSVEINTVLTKLGFNDRSRNQPIDELSGGWRNRAALAKMLIELPDVVLLDEPTNYLDMEGIAWLEQWLYRFKGAMILVSHDRQFIDKVVTRTIEIENYHFQEYEGNYTDYVRKKKMRKKELDRQFEWEEELLLMESEAIDDRANRNSGSKDRLSRKLADNKKRIEPHPVNVLITDIYERLRFPDKLCEVKKIGQTYEGRQIFENVSFDIQKEDRLVIAGPNGSGKSTLIKALTGQEKPDSGEVVWEKGVYYAYFNRTWEELDPKDTVSHAVNTYGLGLDAPRKKVNKFLAMLQFSEADLSKAIGNLSGGQKARVALAKCLLSGAAVIILDEPTNHLDLTSIQVMEQALIHFPGAVITVSHDRFFIDKIGTKMLTFDLVTGVTEQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKE1</accession>
    <name>A0A398CKE1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAA hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00357">
        <property type="protein sequence ID" value="RIE00357"/>
        <property type="gene ID" value="D3H35_28455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="89"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="315" mass="34809" checksum="A0E839276BFD16CD" modified="2018-12-05" version="1">MKLVTYMKEDRQSLGLKTERGVLDVEAASALWPAEPGTPSTVMEAIRGGKRAIELLERLRVKAEQAADGAVWLREEDLEWGPSVTHPNKIICIGLNYRKHAEETGSPIPDHPILFNKFNNTLTANKRDVAIPGVTDKVDYEAELAVVIGSRAKYVTKESALDYVFGYSCVNDLSARDLQMRTSQWLTGKSCDDFSPLGPYLVTADEVGNPNDLEIRAYVNGEIRQQSNTADMIFHVDELVSYVSRYMTLEPGDILLTGTPEGVVMGYPPEKQVYLKPGDLVKIEIEGLGSLENRMTAEFSAEESIPSTVGGRNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKT6</accession>
    <name>A0A398CKT6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rimP</name>
        <name evidence="6" type="ORF">D3H35_11585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03323">
        <property type="protein sequence ID" value="RIE03323"/>
        <property type="gene ID" value="D3H35_11585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036847">
        <property type="entry name" value="RimP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74942">
        <property type="entry name" value="SSF74942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="DUF150" evidence="4">
        <location>
            <begin position="15"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="DUF150_C" evidence="5">
        <location>
            <begin position="88"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="153" mass="16952" checksum="8F023BCE83049828" modified="2018-12-05" version="1">MSAPKIKSVVEEFATPFLTDNGFQLVDVEYVKEGSNWFLRVYVDKEGGIEIDDCGRISEFISAKLDELDPIEEAYFLEVSSPGAERPLKKPADVASSVGKHVFVTTYEPIDGAKEFEGRLDAFDGTTMTVVIGRRKHAIPYDKVASARLAIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKV0</accession>
    <name>A0A398CKV0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CPBP family intramembrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02792">
        <property type="protein sequence ID" value="RIE02792"/>
        <property type="gene ID" value="D3H35_19340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="572" mass="63147" checksum="D2C03BA59C968DC7" modified="2018-12-05" version="1">MPRSGWLDMDKRWLIVASIGLIVFLITQVFPMSGDLFATENRATLSRDEARTKTLEIAASKFGLQANQIEDISLTHISNGPASGYFSKEGLMEEFDKKWEKRYPIEVYRADIQVAETGKKLVLLLHMGTGELVRWKDTGTPPSADFGNEEPAATAKHAAAYAEFWGVPATDWEWTGKIDSDGGVPFQSRKAALSEATLKMTVHMPSDYRLTDSSLPPWSGGSVLYKIDVPESFASYMKQQENIANRLSLFAFILPELAMFVLAIVYAGICGSQTSFVRGIFLSAVFFVIYVVITLNMMPALRASDLADGGTSSGNVIPLVVTTIVIYLAMAGMTYFSAVGGDGLWKSMGISLWPRWREAGYGADVLRSMLQGYPLAVLLLGAQSLILLILEKTLNVFASSDPSQSTYNMTLPWILPLLAWCAGISEEIQSRFFGIALFRKWFVGLARAITRREPSSRTVALLTTAAILPPGLVWALGHVGYTIYPFYTRVIELVLLSLLFGWFMLRFGLMTVIFAHVTLDSILMGVQMIFDGLPGDLWAGMFSIVMPALVGIAIWALHRTFRRRNGSPLSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL34</accession>
    <name>A0A398CL34_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01949">
        <property type="protein sequence ID" value="RIE01949"/>
        <property type="gene ID" value="D3H35_14345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="120" mass="14071" checksum="80AE01EF3C366E58" modified="2018-12-05" version="1">MIICETAHLKSLASWIDPEFGDCNFPPTLNIDVDKESRIQSRAELFLQGRDNIRMGRSARRQRRSDPTDFSANYFEKFVYDQDFADAPHVKRRKGCLEREIRALQYLAVTESLLVEYIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLC2</accession>
    <name>A0A398CLC2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_07815</name>
        <name evidence="5" type="ORF">D3H35_14445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000028">
        <property type="protein sequence ID" value="RIE04146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01967">
        <property type="protein sequence ID" value="RIE01967"/>
        <property type="gene ID" value="D3H35_14445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04146">
        <property type="protein sequence ID" value="RIE04146"/>
        <property type="gene ID" value="D3H35_07815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="119"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="187" mass="22146" checksum="0C2214A580FADBF3" modified="2018-12-05" version="1">MDHEYLKNMTDGLDRNALLEDLMLTYGKDVWNYAYFLTRRKDLAEDIAQDVFVKAYNSLYSFRGDSPMKAWLLTITRHATLDYLKSSWVRKVAFLTPWQQQERSVPSAETEWFDSMEKREIWDSVLSLPRKLREALLLYAHHHLSIKEIAELMNLNESTVKSRLFRARAAMNRQISREQRADGRNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLH2</accession>
    <name>A0A398CLH2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02049">
        <property type="protein sequence ID" value="RIE02049"/>
        <property type="gene ID" value="D3H35_14895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="368" mass="41397" checksum="6DDB32C684EF32C5" modified="2018-12-05" version="1">MQQRVLLSIMLGWIPGLGHLLLGRIGRGILYPAGFVGTLFLGVVATDDAQSIGPFVLSVIFAGGLWIVNMVDLWKYVFRRGGSPSLGRDAQSVQGATSITAANPDNELSNERFATALLSVIPGLGHFHMGLMTRGLTLLLSFVGWIVMTFFIAIFTEQEGFFVFLGALPILWLYNIFDAMRLINLKQSGEKLEDRSLFEDWEQVREDGRRSKMVAMLLSLFPGAGHLYLGLQRRGIQLMGAFLFSIYILDSLRLNLFFFLIPLLWCFAFFDALQLASRWQRNPEEVRDVPLVDKVLNHQRWLGLALLALGLYYLADRFLVDWLEREFPKAAVGYYFREYTQTAVVAVLLIGGGVRLLFGSKKERGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLL7</accession>
    <name>A0A398CLL7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MMPL family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_15225</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02109">
        <property type="protein sequence ID" value="RIE02109"/>
        <property type="gene ID" value="D3H35_15225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="572"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="635"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="684"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="710"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="213"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="570"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="776"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="804" mass="85668" checksum="DC20AABC1B7BD48C" modified="2018-12-05" version="1">MKLHDMLGKWGRFVYRARIVIVALWIILFVLGASVFGKLPAILSGGGWEITGATSTIANEKLASGFEGRSASSLTLVLRDAQHKAGTAAYNDKLRQVVERLKTEEGVTDVFSILDASDSVRGGLIGDDPYVSTAIVDMNIEFDYLINQINEYQDRVAEQAKSLGVEAYLVGTAAFQGENSAQSQEGLAKAEMIVFPLIIVILLLVFRSFVAMLTPLLVTIASVIVAMGVIYAAATQTELSVFVTNAAMMLGLGVGIDYSLFIVSRFKQELERDNTAGALAKTLATAGHTVLFSAITVIAALSALFVVPMPVIRAIAFGGIAVVFIAGLASLSLLPAVLGMLGARINKGRIPFLNRPRQAGTVSGWRRWTNAIMRRPALFLIVTLGALFVAAIPAVGMKLYSPDIRMLPAETGVRQGFTVLEKSFGVGSTSPLTIVLDQAEGSWAAPEALKRLAALQAELEKHDHVLKVTSFASMFQGMTPEAASQLLQANDGAALPGDVKWMISRYLSGDGHKAIVEVEMDQYGSSDAAREVAKQFHDKLLPSFDLPAGTTYSIGGETMSGMDTSNAIKDSLLPALGVMLILIFVILVLTFRSILLPLKAIVMNLFSVAATFGILVFVFANGHGSELFGVESNGYIIHFVPVLLLALLFGLSTDYEVFLVSRIKEEYDRTGKNEESIAEGMEKTGPLITGAGVLMFAVFAGFAFSGVLPIQMLGFGMAIAIAIDATVIRLLLVPVAMKLLGRSNWWFPGRKTAAYAGNGYDAVAPVIRVSAAQSADGVGTDGPGSGARSLVVNPVKSSTDVPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLP6</accession>
    <name>A0A398CLP6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_11080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03573">
        <property type="protein sequence ID" value="RIE03573"/>
        <property type="gene ID" value="D3H35_11080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="140" mass="15713" checksum="F0BB9C060B6A028D" modified="2018-12-05" version="1">MSVYTTNSPKEWEGVPLMSVYTTNSPKEWEGVPLMSVYTTNSPKEWEGVPLMSVYTTNSPKEWEGVPLMSVYTTNSPKEWEGVPLMSVYTTNSPKEWEGVLLLHDHKGSLSTKKTPFSVQRTLKAFLLVFLASSGGALYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLR4</accession>
    <name>A0A398CLR4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000035">
        <property type="protein sequence ID" value="RIE03593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03593">
        <property type="protein sequence ID" value="RIE03593"/>
        <property type="gene ID" value="D3H35_10665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="91" mass="10108" checksum="73158C8F7AF682AB" modified="2018-12-05" version="1">MNANGYAGIRFLLRLSLEGAQFMKELLVRDTWPVRAQAELELTGIAPRLPVKIAFDPPLLHRLLAELCDESGLVSRSALVQFFSKEPARSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLY4</accession>
    <name>A0A398CLY4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome c oxidase subunit 2</fullName>
            <ecNumber evidence="18">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">coxB</name>
        <name evidence="23" type="ORF">D3H35_15955</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 18">Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="18">Binds a copper A center.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="18"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02229">
        <property type="protein sequence ID" value="RIE02229"/>
        <property type="gene ID" value="D3H35_15955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04213">
        <property type="entry name" value="CuRO_CcO_Caa3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034236">
        <property type="entry name" value="CuRO_CcO_Caa3_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014222">
        <property type="entry name" value="Cyt_c_oxidase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011759">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02790">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="SSF81464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02866">
        <property type="entry name" value="CoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50999">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0186">Copper</keyword>
    <keyword evidence="10 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_TM" evidence="21">
        <location>
            <begin position="23"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="20">
        <location>
            <begin position="124"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="22">
        <location>
            <begin position="244"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RIE02229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="350" mass="38456" checksum="E86BE3468AB696E9" modified="2018-12-05" version="1">MNRWHVTKRLLPVLAGLMLLLSGCGRADLSTLNPQGPVAEKQFDLMKLSIGIMALVVVVVFAICIYVLIRFRRRAGDKTIPKQVEGNHTLEIIWTVIPLVLLVILGVPTIQTVFGLAKDYSKDANAVQVKVTAHLYWWEFEYPQYGIKTAQELVVPTGKKIQYELVSADVKHSFWIPAIGGKMDTNPGLTNKMFLEFPNEGVFRGKCAELCGPSHAYMDFKAKAVSQASFDKWVAAMKAPAVTAADKDIAATFEAKCLTCHAVGEQGQSGAPNLTGVGGRQTIAGILYNSDVVSDPQEEDKTVEQNLKDWITDPQKIKPGNQMPSAAVNELTQEQIDGIAKYLAGYKLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLZ5</accession>
    <name>A0A398CLZ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heme uptake protein IsdC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">isdC</name>
        <name evidence="6" type="ORF">D3H35_16015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
            <topology evidence="1">Peptidoglycan-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02239">
        <property type="protein sequence ID" value="RIE02239"/>
        <property type="gene ID" value="D3H35_16015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009274">
        <property type="term" value="C:peptidoglycan-based cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030492">
        <property type="term" value="F:hemoglobin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015886">
        <property type="term" value="P:heme transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06920">
        <property type="entry name" value="NEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019909">
        <property type="entry name" value="Haem_uptake_protein_IsdC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006635">
        <property type="entry name" value="NEAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037250">
        <property type="entry name" value="NEAT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05031">
        <property type="entry name" value="NEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00725">
        <property type="entry name" value="NEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158911">
        <property type="entry name" value="SSF158911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03656">
        <property type="entry name" value="IsdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50978">
        <property type="entry name" value="NEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="NEAT" evidence="5">
        <location>
            <begin position="77"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="391" mass="40914" checksum="5F352D0858B01910" modified="2018-12-05" version="1">MSTSTSTSTSTSTSTSTSTSTSTSKLVTSINAWIIDGEPTRRSWISLKYRLAVRSLLAALGIWLSIGSSLVFAETALADGKYTADYLVLKAEDDSVSMANDYWEKPATVVVSGGTAKVQLKINHSKWVTEFKVPGNGGYVDTKVVVVNKREDKRVVEFSANVTEPIVAKIHVTVPDIDYDHDYTIRLVFDSSSFKLVSSAEKNNGAAPTKEPASTPAATGKTEPANAKAEQPTGSEAPKPASEPQEAASSTQKPETATKASATAKADAASAGEKSSESVANAEEASTESSLASERPTDQAPSTEELKENDSEAASPSASASGEALSSDEDDRQTAASGDGEANQAAALTGTDAPKEASNSRIQWWIAGAVILLLAGAALYVQRGKNRKPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM64</accession>
    <name>A0A398CM64_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_25695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00957">
        <property type="protein sequence ID" value="RIE00957"/>
        <property type="gene ID" value="D3H35_25695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017462359" evidence="4">
        <location>
            <begin position="25"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="221"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="293"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="579" mass="62895" checksum="AA8B5A5E12B62F39" modified="2018-12-05" version="1">MNMRHLSVKAKLLLMLIVPLLLFATTSVYLLTLNSSNINHLSDTLFETGNRSSSLVLNADRDMYQALTSYMTAISESSDDKKRDAAVKDFQENVGQVNDRLQQAITIVHDQGLGDRAHPDSGKSLEQIATEVRKEFDAWAKLANSHLENMQNITPEGEDKFGASFNSARDNVNQFGEIIDSYSEDIIDEANADKKKTNLITYSSLIVEWIVLLTAGALLIRQISRTVHNVMNKTRRVSEGFLDVPQQTKYSNDELGRIQQSIDSMIGRMRELIGSIADNTRSVAAASDELHASANESSLAAGHVAENIQEVTSLVEAQSNITAEASKAMEEMAIGVQRIAESTGIISEHASDTNGQADYGNELLIKLRGQLDEMSRSIINMSRSVFVLNEKSERIGAITEKITGFANQTGILSLNASIEAARAGEHGRGFAVVAGEIRKLAASSLESANTINDLIADTRTEIGNASAYMKSTVSQAEKGTAFMEEVADGFQAIAASIKQVASQIHDTSAVTEQMSASSEEVSASMEQSTSSVREVASKAETVAAATEEQLALVENIAHSAEQLQEVVRNLNKAVHYFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM74</accession>
    <name>A0A398CM74_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03753">
        <property type="protein sequence ID" value="RIE03753"/>
        <property type="gene ID" value="D3H35_09350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="67" mass="7935" checksum="82164CF40B45C8F7" modified="2018-12-05" version="1">MTQYEFDNFDWLIPAWTLNPTKMVVKSVFFAFFYELSKRKNSANEKSRKKVQKKSKNVGTISFFACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CML7</accession>
    <name>A0A398CML7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03705">
        <property type="protein sequence ID" value="RIE03705"/>
        <property type="gene ID" value="D3H35_10435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="183" mass="19924" checksum="D58BDF6730263162" modified="2018-12-05" version="1">MKVESMTKALAWIAILGGIARIGMSPSAVIWGTDSDQELTFAMIACCLMTIGWFGIHYYQSHKTGVTGFISYVLITLSNTLTTCLVWSQIMGSNTGTLKETVLSINSGAALLGMIMFAIQTVRARIYPVWPVALFLLFPVASFIPLVTEWATTLWGLAYIGFGLYIVADKTVKNKSVYSSVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMM0</accession>
    <name>A0A398CMM0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01147">
        <property type="protein sequence ID" value="RIE01147"/>
        <property type="gene ID" value="D3H35_22330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="323" mass="36394" checksum="6268EEC780EBD8F6" modified="2018-12-05" version="1">MGQNEAVREFREDDDFHYFDRLVWEEHRRRGERIGIHMNGSFSVDTSHRIVRKENYFPDNGDSSLLSRSSKGFVLESNGEIVAVVTVTLHQSGNGNLHMLGCVEGSEAGLAPLIEAGIAFVKSKGGRKLTCFSEILPGQLTNGEFDYWATYGFKPEPYYSQWVVCQDFRRWEAPGELATDNVVPATEIDLEEIAAILEEDGEDLIAESLRYDYEELSPDHIFLKLVDPDNGRTVGIAYYQVNRHENQWGTNTLGIHIRPAWNHQGSYSEIQRFVRCVLASMKQLGVAYAGTRMSSRNLLSMIALCAEGFLLAPMGQVALYRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMS7</accession>
    <name>A0A398CMS7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_22690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01207">
        <property type="protein sequence ID" value="RIE01207"/>
        <property type="gene ID" value="D3H35_22690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="179" mass="21313" checksum="35D8A1358F3164AA" modified="2018-12-05" version="1">MIYFLCHYFDELTGPFRNLSDLELAEAEQVLNEIRIRKKGFASERPMNYLTIRRSLELKARDLFIMKGGKPIRSYPHYMTVGECPWLLEWFEKGKELHIPLTKFDPNTVSFTYGDLFPTMRYQDGKKYRGQVYTLNEIYQVINEFGMPQEWNPSGNYGPERYIEAQVWDDKPLTAWLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNE8</accession>
    <name>A0A398CNE8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
            <shortName evidence="10">NN:DBI PRT</shortName>
            <ecNumber evidence="4 10">2.4.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">N(1)-alpha-phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">cobT</name>
        <name evidence="11" type="ORF">D3H35_08580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate</text>
            <dbReference type="Rhea" id="RHEA:11196"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15890"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="EC" id="2.4.2.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CobT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="4 10"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04133">
        <property type="protein sequence ID" value="RIE04133"/>
        <property type="gene ID" value="D3H35_08580"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00061">
        <property type="reaction ID" value="UER00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00230">
        <property type="entry name" value="CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017846">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023195">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03160">
        <property type="entry name" value="cobT_DBIPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="7 10 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 11" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE04133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="331" mass="34477" checksum="788214E15B317ECC" modified="2018-12-05" version="1">MNETRLYLDTLTKPRGSLGRLEELAVQLAGIAGARPEAILKKAVIVMAGDHGVCEEGISAYPPEVTPQMVANFLNGGAAINVLARQAGADVYCVDIGVNADICHESLISRKVGKGTGNIARGPAMSREEALEAINHGIEVVEGLFGQGYRLFATGEMGIGNTTPSAAMLTVLTGIDAEQTVGRGTGIDDEGMKRKRKVVHRAIAVNAPDSTDPLDVLRKLGGFEIAGLVGVILGSAARGCPVVIDGFIASIAALTAYRLAPNSKAYMIASHASQEAGHRPLLARLGLEPMLDLKMRLGEGTGAALVFPLIDAAVLIVKEMATFDSAGVSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNG9</accession>
    <name>A0A398CNG9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4129 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_05870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04153">
        <property type="protein sequence ID" value="RIE04153"/>
        <property type="gene ID" value="D3H35_05870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025403">
        <property type="entry name" value="DUF4129"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021878">
        <property type="entry name" value="TgpA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13559">
        <property type="entry name" value="DUF4129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11992">
        <property type="entry name" value="TgpA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="627"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="506"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="751" mass="83989" checksum="FCFBF2DC06DEAB53" modified="2018-12-05" version="1">MKTATASPQGLPSLRSLKEASFWHQLILERLHRLFAAIIVLQLVQCFGSFWWEETYSIIYGTVTVTILLELLSSRGYYWKFAVQVIFAALFTLAFAPYFHWDGWPDNWHSIEQLRHLIVFHARQLHPFIEIAAGVVLCIRLLSWIGGSRPGVVAVIVGSLGSMAIADSFFPLELWTNIAWIVVAGLGWLFVLHLKQLRSRHPDSWEALAERPFELFVPAILIISLLMISGIFLPRAPVILKDPYTMWTEAQGKEVPAFAGEGGVVKVESSTKSGSSQSGYGRDDRTIGGGFDFDYSPVMTVTTTRKSYWRGETKAVYTGKGWSDRKDPEVIPYVSGSKQVLSLAGERSKEAKTEQIVQTFTFQRKDKIPVLFAAGPLAQLQDIKSSDNVALKWNPNEWELRFNKASRTESYTVVSNVPVLDEDLLRLTPDVADGGASIDIAPYLQLTDKIPQRVKDLAVQVTSEAQATNSYDKAKALAAYLQVTYPYNNKPDISKRQSEDVVDAFLFEIKEGYCDYYSTSFVVMARSLGIPARWVKGYATGFDPANNERMRFGAPPDPLGAGTYTVRNADAHSWAEVYFEGYGWIPFEPTSGFTVPQALPEGKSLEPVIDSLPATESDADESNNESFGWLLPAGGAAGLLLVVSVILWRVRNRNFSLLWNRIRYSGTSPNGRIVREMEKLLRFMSRRGMRREPHETLRETFARWGSKFGSLRADFDGVLQQFERARYGGEGGDASAVAEFSAAAEKIRKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNV1</accession>
    <name>A0A398CNV1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_17015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02408">
        <property type="protein sequence ID" value="RIE02408"/>
        <property type="gene ID" value="D3H35_17015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="74"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="280" mass="31900" checksum="3EB304D880B688F5" modified="2018-12-05" version="1">MNNNRLNRTILIVNKYIILIVISSIILVPFIWMLSTSLKTFSNIFLFPPQWIPSPIAWENYVTLFQKSPFHLYMFNSFYIAVLVTIGACLFSSLAGYAFAKIKFPFRNAIFLILLSSMMIPTESTAIPLFIWFSKIGFIDTHLPLIFPPMLGAAGMFGVFLFRQFYIALPNELDEAAKIDGCNPWMTYWRIILPISTPTFATLSIFTVLNTWNDFFEPLIYLNSSKLYTIPLALSLFTTESGTEWHLIMSASVIASLPLLIIFFLAQRKIIEGIAITGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNV8</accession>
    <name>A0A398CNV8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SpoVR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04032">
        <property type="protein sequence ID" value="RIE04032"/>
        <property type="gene ID" value="D3H35_08750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007390">
        <property type="entry name" value="Spore_V_R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30029">
        <property type="entry name" value="PTHR30029"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04293">
        <property type="entry name" value="SpoVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="467" mass="55210" checksum="6ACE3377A681C394" modified="2018-12-05" version="1">MRLLDEHKELERSIEEITEIAQSFGLDFFPMRYEICPSDIIYTFGAYGMPTRFNHWSFGKTFNRMKMQYDFGLSKIYELVINSNPCYAFLLDGNSLVQNKLIVAHVLAHCDFFKNNARFSVSNRNMVESMSAAAERISQYEIEYGTETVERFLDAVMAVQEHVDPGIHKPYGLDKRRYMEWQSRRDKEDERTTKNATPYDDLWGLEPSAPDTEAARPEPSSDNRKFPPRPEKDVVWFIQEFSPFMEDWQRDVMSMLREEMLYFWPQIETKIMNEGWATFWHQRIMRELSLTSEETIEYAKLNSAVVQPSRSSINPYYLGLKIFEDIEKRFGRERIFEVRELDSDISFLRNYLTKELTDELDMYVFEKKGPEWQITDKTWESIRDQLVFSRVNGGFPHLEVTDGDYQRNGELVITHRFEGTELDLKYVERTLPYLVQLWGKQVHLETVVDDKSVLFSCDGKKTSRKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP92</accession>
    <name>A0A398CP92_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1648 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_23295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01311">
        <property type="protein sequence ID" value="RIE01311"/>
        <property type="gene ID" value="D3H35_23295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012867">
        <property type="entry name" value="DUF1648"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043831">
        <property type="entry name" value="DUF5808"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07853">
        <property type="entry name" value="DUF1648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19124">
        <property type="entry name" value="DUF5808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1648" evidence="2">
        <location>
            <begin position="148"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5808" evidence="3">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="364" mass="41117" checksum="D095B75479A75EBB" modified="2018-12-05" version="1">MTMAMWNWTTLGIVELLIVLLFSLQPYYGMKTVLFGVAVPEEDRELDQIRALRKRFAWRIWITAIVAFGAGGGVSYSLSGDEAAIILTVTFLQLILFGSIFGMCRQAALKLKSERGWVVTPSERRVASLLPRPQNMTLHNGWFLVHVLVIAVCVIFAIALWDRIPDTVVTHYGMNGKPDTVSPKSIGFVFMLNFIQLFLAGLFWFINYSIRVSKLQLDPKDPEKSLEKQRKFRRINSIFLWALSLVIVTFFGIVQAFMIYDWPQDALNGIVIALPLLLIGSVIGLVIYLTNKGLDQQSNAPVQDERHWRGGGMIYYNPDDAALFVDKRFGMGWTLNFARPMSWVIMGGTIAIPLIIVLFAVLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPG9</accession>
    <name>A0A398CPG9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IclR-ED domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_01340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000013">
        <property type="protein sequence ID" value="RIE05296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05296">
        <property type="protein sequence ID" value="RIE05296"/>
        <property type="gene ID" value="D3H35_01340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IclR-ED" evidence="2">
        <location>
            <begin position="4"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="132" mass="14814" checksum="6579D5FC65677BDA" modified="2018-12-05" version="1">MQFSTQIGQTQLLHNSGVGKALAAYMADDQLLQAIAKHGMPKTAAHTMTSLEEFKPFLVGVRETATPSRTRKAKLEYAASPPPSSIIPEGRRRSRHYRTEQRAPQPRLRRMRRAAPRQSAGCLQQAWLHTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPL9</accession>
    <name>A0A398CPL9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_06015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04475">
        <property type="protein sequence ID" value="RIE04475"/>
        <property type="gene ID" value="D3H35_06015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010167">
        <property type="entry name" value="NH2A_AcTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30602">
        <property type="entry name" value="PTHR30602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="153" mass="16941" checksum="CE1196E785F4C9A7" modified="2018-12-05" version="1">MTVVCRKAESSDVDALHELIQSYAEQGIMLPRSREALDRNIGTFIVAEDDGRLVGCGSLCRLGNDLVEIRSLGIAGGYKGQGIGSRMVDSLIDEARSQRIPKVMALTYEVAFFQKNGFRVVDKEIFPEKVWTDCVNCAKQHCCDEIAVLKVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPU1</accession>
    <name>A0A398CPU1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transglutaminase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_19135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02758">
        <property type="protein sequence ID" value="RIE02758"/>
        <property type="gene ID" value="D3H35_19135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="299"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="382" mass="41268" checksum="70309A6A5F05C409" modified="2018-12-05" version="1">MNLSGNGWGLSLSDANLVTVALVAIVAVSLLQGVWRGASGSAKQLFFFLTSAIVAVAAIVVAAWGASTASPVLQAYLAEHGMERPAADASYFAQLAYTVVSGLRDFPLFRFAALFLLLYAALRLLTGFMVRILAGVGSIPMALLPSGGSVSRTVGGAIGAALGAGRALLFTALLFGYCALWPQGPMTDYIQQSGLYREAAAQIIRPAAGVLLEERLPVFAKAMTGELDQLWQRRYDVIDAELPDDIVNAAKSVTEGKTGDEAKAVALYDWVGSRIVYDDDKVTAYEERNEWREQNPEQTFATRKGVCIDYARLYAAMARSVGLDARVVTGLGYDGQGGYGPHAWNEVYLQERQAWVPLDPTWAKTGDWFDPPRFADTHIRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPW1</accession>
    <name>A0A398CPW1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04472">
        <property type="protein sequence ID" value="RIE04472"/>
        <property type="gene ID" value="D3H35_07780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="16"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="231" mass="25290" checksum="A8BF4FC1BBAD6CF5" modified="2018-12-05" version="1">MRSGVDAVGGVPYNDRDSREHLEFVFRLAEEWGKPIDLHLDFSDDPGTMAIADVVELTKSFGMQNRVAVGHLTALGSAEPETAQRLANDMAEAGISVFALPATDLYLNGRGDAARPRRGLAPVRTLLDAGVNVCFGTNNMRNAFTPFGTGDPLDIGLLLAQTAYMGSREDAAVVGMCTERAAEALRMTDYGIKSRIGCRACAYRRRGLRRANALLYDRPRERKVWRNGIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPY2</accession>
    <name>A0A398CPY2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_13985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01887">
        <property type="protein sequence ID" value="RIE01887"/>
        <property type="gene ID" value="D3H35_13985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="240" mass="26756" checksum="3E954AD3E8217C5D" modified="2018-12-05" version="1">MGYRPMAELRSWATMALTSLLPAGAEMAYIAGSSGQGRTPAVIVADLDGDGFPEISVVYRMHGELRIAILHRNQDHSWRQVANFKGLGCEVTDLIVAPIAAPGKNTLLIGWQIGSIWSVLDLIEWTPGGYKRLLPGDRYYSKLEAEDMPGGPGAPSGQAEIALWVHDTGEAYKVSVYRWDGEKLVSASPEATRYYFKRVVRYYEDLVKEYPDYTFYKTYLEDARKKANARQANAGKSLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPZ4</accession>
    <name>A0A398CPZ4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03369">
        <property type="protein sequence ID" value="RIE03369"/>
        <property type="gene ID" value="D3H35_11865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="198" mass="22901" checksum="8AD280147AD99D40" modified="2018-12-05" version="1">MKPYIRQYFFLILGGLIIVSGIGYTVIDFLNNNSLGSRVKIIAPDTKEVLLAPGRYDLFYEYSSKVYDAGIIKLKRENKFNDPYELISVKISDVRDGKVLKIVKESSTSFTLDDIKGESLYSFEVLEEGKYSVEIKTIDEVKEQITISLVNDFTKELFNGFKRVGIILVFSIPFLLIGWFMYSREERRRRIQIVGYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ01</accession>
    <name>A0A398CQ01_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03379">
        <property type="protein sequence ID" value="RIE03379"/>
        <property type="gene ID" value="D3H35_11925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="186" mass="21577" checksum="B9E8B9FD6F644F23" modified="2018-12-05" version="1">MLSHKINDDIQLKMLDHRYVDELFGLIDKNRAYLREWLPWVDGSISIEQTKSFVQSSLHLFAENNGFQLGVFYKDRIAGCIGLHYIDWANKKTSIGYWLAEEFQGRGLMTRACQALIDYLFHDLALNRVEIRAAVLNAKSRAIPERLQFANEGTSRQAEWLYDYYVDHIIYGMLAVNWTKPRGGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQG5</accession>
    <name>A0A398CQG5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Negative regulator of flagellin synthesis</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">flgM</name>
        <name evidence="9" type="ORF">D3H35_14935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FlgM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02057">
        <property type="protein sequence ID" value="RIE02057"/>
        <property type="gene ID" value="D3H35_14935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035890">
        <property type="entry name" value="Anti-sigma-28_factor_FlgM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007412">
        <property type="entry name" value="FlgM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031316">
        <property type="entry name" value="FlgM_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04316">
        <property type="entry name" value="FlgM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101498">
        <property type="entry name" value="SSF101498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03824">
        <property type="entry name" value="FlgM_jcvi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FlgM" evidence="8">
        <location>
            <begin position="33"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="87" mass="9827" checksum="ED79EE545946F6A9" modified="2018-12-05" version="1">MKINETRRVGAINPYQANNGQRTESSGRKRQTDNVQFSSEAMEMLAQTRLNGPERTQKLEELKQSVATGSYHVDAGKLAEKLLPFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQL6</accession>
    <name>A0A398CQL6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03559">
        <property type="protein sequence ID" value="RIE03559"/>
        <property type="gene ID" value="D3H35_11005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="170" mass="19791" checksum="A238FA58BA8117E6" modified="2018-12-05" version="1">MAGNLLYMPYTFLMIIGLIILFVIIMLKKGKRAVKVFLSISVPVLILFQFYFWNLEFNNYVKSYLFPSKAFKCADIEELKSLSIPLPERTVFKGKEDGCSPFYLTYVNVNGFKSYYQKELQTLKDTGKIQNYRYENKGYLVELSSGSKIDIFFHRREGESGLISIDYNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQN7</accession>
    <name>A0A398CQN7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04853">
        <property type="protein sequence ID" value="RIE04853"/>
        <property type="gene ID" value="D3H35_05150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="92" mass="9785" checksum="DDE45F80D52587FD" modified="2018-12-05" version="1">MTGGTGNGGRNLVTTPRSLQGSGNVQKDGGPSSGGQATEGGQSPMLDGGSQSYEDVYSTYASEARQSLNRNQLPQSMQQKVRDYFDEIQPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQV4</accession>
    <name>A0A398CQV4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysine transporter LysE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_23315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01314">
        <property type="protein sequence ID" value="RIE01314"/>
        <property type="gene ID" value="D3H35_23315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="259" mass="28301" checksum="299641CD3FB441F7" modified="2018-12-05" version="1">MFKSCRLDHQYIINATFAGRIFCYIHLEHYARMGKSNRSRGTIPMAALHSFTQGFLFSLSLCFDLGIVNVAIMKTGIERGIKPSFLIGFGSCFGDLTYLALALLGVGVIFQIAWVEWTLWIVGSVALFYLTFKALRETWRPKEFGALGAAVVRSPVKDWTAGLGLALSSPSVIAWFALVAGPIVSSMRIHSGFDLTYFVLGFFAAGVLWSLAVALVSSSTGKLFRGSIVRFLSLGSAILFLYFAIRIFAGGLQNLVLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQV5</accession>
    <name>A0A398CQV5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YheC/YheD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_03375</name>
        <name evidence="2" type="ORF">D3H35_03400</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000019">
        <property type="protein sequence ID" value="RIE04935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000019">
        <property type="protein sequence ID" value="RIE04938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04935">
        <property type="protein sequence ID" value="RIE04935"/>
        <property type="gene ID" value="D3H35_03375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04938">
        <property type="protein sequence ID" value="RIE04938"/>
        <property type="gene ID" value="D3H35_03400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026838">
        <property type="entry name" value="YheC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38437">
        <property type="entry name" value="PTHR38437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14398">
        <property type="entry name" value="ATPgrasp_YheCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="391" mass="43387" checksum="63CC3EA0D31C8A2E" modified="2018-12-05" version="1">MPVIYPDSDAFIRETDKAPALGILVCEKNALPPFAESRFIRKLGEHGSRQGLSVFAFAPWTWNPADGTVQGWRFEPSLLKWQREAHPLPALVYDRSWPANESEKRKYRQALRKLNSARRLAHLNGPLPGKAAVQLALAGDERLSPYLPPTRLYEGTDSFLRWLTRNRGAAFLKPAAGSQGRRVVAVRRKADGSVSLRGRLADNRAFSCDCADFHEAAARIGRWIGGREYVMQPLLDLRNAKDEPFDIRALVQKNGKGRWALTGTAIRRGQAETVTANLHGGGTAEPAQAALASMFGGEKAVMLLEEIRECCLHVVCTLEQCYGRFAELGLDFGVDRSGRLWFLEANSKPGRAAMECFGEAVARTAAGRPVSYARHILFRSPGRVIHEFDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQZ2</accession>
    <name>A0A398CQZ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_03290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04975">
        <property type="protein sequence ID" value="RIE04975"/>
        <property type="gene ID" value="D3H35_03290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="43"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="385" mass="43325" checksum="92B232B920E37962" modified="2018-12-05" version="1">MGTSGGEGGYLMIQTASAAKEPRIGDVIPLLWERLGPNRLMYIFALLLCLGQTLSHILVPIGVSIYYQKLEQGEYGYIQALVLVCTAVTFFLLGLNMLGVYLKLVAMTRLNRDVTLRLADEAQRLPLERAQGSHSSDLVQRVTSDSSRTTGLLTLVLDDMGNLFIVILCASVYMMWLQWQVALLILMIAPVIIVLSHSLGYRLQRIGYEVAEQEAVVRQYQQETLQGIETIRAYGIEEWMTESFVGERARLNKMYMKRMWWQQWISVVTSAISNMMVIVMLLVVGWLAVNGSMPIGSLMVFFMLISQMIQPMQALVGVLGQINGGLGGAVRMMALERAEKEPTKIRLPDSDLTTGNPGLWLTDTRFSYRNMRHWMSLTQSWVLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR50</accession>
    <name>A0A398CR50_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplE</name>
        <name evidence="10" type="ORF">D3H35_02300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05002">
        <property type="protein sequence ID" value="RIE05002"/>
        <property type="gene ID" value="D3H35_02300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_L5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="8">
        <location>
            <begin position="25"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="9">
        <location>
            <begin position="85"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE05002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="180" mass="20405" checksum="5BC759AD536C892B" modified="2018-12-05" version="1">MAARLKERFNNEITPALMQKFSYKSVMQVPKVEKIVINMGVGEAVQNSKVLDAAVVDMQKIAGQKPVITRAKKSIAGFRLRENLPIGVKVTLRGDRMYYFLDKLFNISLPRVRDFRGVSSKSFDGRGNYTLGLKEQLIFPEIEYDQIDKVRGMDIVIVTTAQSDEEARELLTQLGMPFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR51</accession>
    <name>A0A398CR51_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_03820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04630">
        <property type="protein sequence ID" value="RIE04630"/>
        <property type="gene ID" value="D3H35_03820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025942">
        <property type="entry name" value="SpoVIF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14069">
        <property type="entry name" value="SpoVIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="91" mass="9865" checksum="5FDBFA514D57526B" modified="2018-12-05" version="1">MDKKLSKDVLGAVNKKTGKTISESSIKKIAGSVTPNTLQSETQIRQLVKQVSQMAGVPVSEDTVKEIVSAVKKSGMNMNNLEGIMKMMLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR55</accession>
    <name>A0A398CR55_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NrdH-redoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01911">
        <property type="protein sequence ID" value="RIE01911"/>
        <property type="gene ID" value="D3H35_14115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="96" mass="10817" checksum="A70B46CA3D3F189B" modified="2018-12-05" version="1">MSAEQARKYILWGKKGCSYCERVKGVLAANDQAYAIVDVEGRDDLRDILELKYGTRLVPVVEVQNRESGDGVYEAYVHTELDRFEALFAESAQVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR91</accession>
    <name>A0A398CR91_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_09505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03779">
        <property type="protein sequence ID" value="RIE03779"/>
        <property type="gene ID" value="D3H35_09505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="3">
        <location>
            <begin position="13"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="343" mass="38286" checksum="BC14107C4B2DE8D2" modified="2018-12-05" version="1">MKNRNGGSPVLAIVVPCYNEEPVLSMTVAQLAAVLDNLKLKELISEESFLLFVDDGSKDNTWSLIAQHQASSRHIAGLKLARNAGHQKALWAGLMKAKAFADCVVSIDADLQDDPSIIRDMVIHFHAGCDVVYGVREKRSTDTYFKRQTAESFYKLMVKMGANIVYNHADYRLMSRRALDNLEKYEESNLFIRGLVPMVGLRHATVYYNRAERAAGESKYPLKKMLSFAFDGITSLSVTPIRMVTVTGFIVFLLSIFFGLYALISKLSGHSVSGWASLILSIWFIGGIQLMSIGLIGEYIGKVYIETKRRPRYHIDAEAGLARTEREEASAEQTSIGLSPMMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRH1</accession>
    <name>A0A398CRH1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02427">
        <property type="protein sequence ID" value="RIE02427"/>
        <property type="gene ID" value="D3H35_17130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="212" mass="24372" checksum="2AD3E85582990C29" modified="2018-12-05" version="1">MIYKVAKTEKEFHGIYDLRAAFYKKLTSDLNNPHDVSASYMVERDERHIHLIAVEDEIVMGTLSICVPDANGLLECERLFGVDLSRFKTGNDMELRKLGIRNCNKMSTLTMILCSLGFEFAASCNAGSIFNVSTKLEYNNRFYGKLGFHQVADVKHVLNDRIMRLDVQEVLASQMIIPFRRMVLDKYRDTFEQIQEEYRRIASSPRASLSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRU0</accession>
    <name>A0A398CRU0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05282">
        <property type="protein sequence ID" value="RIE05282"/>
        <property type="gene ID" value="D3H35_01825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="355" mass="41066" checksum="52F5DC79F4ED2CE8" modified="2018-12-05" version="1">MLVSFKLRIVHQEERKHIKLVYDRSEATQRTYAPQSFIGLLVADLEKGKHFVEVDLDDPFFRVFTVSAEAPIDFGRIGLHSAHLSLDYGNPADPATLKHADFVFDKDRAEARRFEVFMNERLDTDYEYSVQYHFDPLSGWEGSKTSYEQPPRRKEDRTLLLNPFEDIGFLELQVKASNVDWGVVDSIEVRLEYRQPGGELLSKVLILTEQAGTLSWNIRLDDKTKRTYTYRLVHRLKDGTNRETETFSSEASLLPVDDPFPASIRIQFLPLFDTEKVEAVFIDVAYSDPDNRYEREEQLKIKKEMTDSVPLTLAIVNPALKAFRYRLTFIGTDRSMRRGAFVETAETLIPVREDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRZ8</accession>
    <name>A0A398CRZ8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxygen sensor histidine kinase NreB</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nitrogen regulation protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D3H35_00745</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05352">
        <property type="protein sequence ID" value="RIE05352"/>
        <property type="gene ID" value="D3H35_00745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="39"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE05352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="233" mass="25678" checksum="8B84DDE08059367C" modified="2018-12-05" version="1">MNGMAIQSEFEPYVLLEERNRIAEEIHDRICPHLFGIACAVHSVEEDWSGMTEEQKLGQLREIQEAAAAATRELRATIYDLSLSEKGGVSWIHGVESLLASQAKLNGVRIRFRTADSDRRLPIHHQKALYRTIAEAVGNAIRHGASSIIDVKLTLRRCSVTLRIADNGKGFDMDSRPPSKKDSGFGLYNMKALASSLGGNLQIDSSVGSGTRIVVRLPLDQARDERGQTLKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSG7</accession>
    <name>A0A398CSG7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAA hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05150">
        <property type="protein sequence ID" value="RIE05150"/>
        <property type="gene ID" value="D3H35_01910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="89"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="298" mass="32810" checksum="CA9A1AEA7C4EAB11" modified="2018-12-05" version="1">MKLLTFIYNGEYRMGVRTERGILDVEAAVAALAPEEADIPTTVRRVLSGGDKAFASLRRFVDELQNNAAPYLKDEETITWGPAVTDPGKIICIGLNYRRHAEETNNPLPAYPILFNKFANTLNGHGHEVPLPRTSQQVDYEAELAIIIGKTAKYVGEEEALDYVFGYAAANDLSARDLQLRTSQWLAGKSCDYFSPIGPYLVSKDEVGDPNQLDISCTVNGQIRQSSNTSDMIFDCKQIVSYVSQCMTLSPGDILLTGTPEGVVMGYPKEKQIYLQPGDVVTVSIEKLGSITNRMVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSN5</accession>
    <name>A0A398CSN5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02817">
        <property type="protein sequence ID" value="RIE02817"/>
        <property type="gene ID" value="D3H35_19485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="273" mass="31567" checksum="364F5CEA10104451" modified="2018-12-05" version="1">MTREFQTIYLDYKVTPTPRFGWEKKPHGKLHAIIDRGREMYAERLSTFRTLAEPLSRIAMREDQARSDRPYWRNPWFTGLDALALYGLLSECKPQRYYEIGSGNTTKFAKQAVRDGQLGTYMVSIDPEPRTEIDALCDKVIRQPLEDTDLTLFDELEAGDFLFVDSSHRSFMNSDVTVVFMEVLPRLKPGVYVHFHDIFLPHDYPAAWAKTYYNEQYVLAAALLAEGTTFEIVLPNQFIVQDSELRALLLPVWERLGAPDLDNVGGSFWLRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSR9</accession>
    <name>A0A398CSR9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PIG-L family deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_06715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04299">
        <property type="protein sequence ID" value="RIE04299"/>
        <property type="gene ID" value="D3H35_06715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="211" mass="24268" checksum="3E3C6FD71ECDD0B0" modified="2018-12-05" version="1">MWYGGTIAKLASENYEIHTLIVTDGCTSQYRDDPRLDEIIVQKQKEAITANTLLGVKQVHFGNLPDMKLDTLPHITVNEVIEKVVREIKPDIVYTHFYGDVNLDHQMVYRSTLVAVRPLPNQCVKELYCYRVASSTEWSPMLSQNTFLPNVFCDISHFIDRKIDAIKAYQTELRVYPHPRSKEYVQAQDLSVGLKYGIGPAEEFMLVRKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSZ3</accession>
    <name>A0A398CSZ3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rqc2 homolog RqcH</fullName>
            <shortName evidence="1">RqcH</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rqcH</name>
        <name evidence="3" type="ORF">D3H35_07265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with stalled 50S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NEMF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04379">
        <property type="protein sequence ID" value="RIE04379"/>
        <property type="gene ID" value="D3H35_07265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00844_B">
        <property type="entry name" value="RqcH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043682">
        <property type="entry name" value="RqcH_bacterial"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="NFACT-R_1" evidence="2">
        <location>
            <begin position="458"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="578" mass="64853" checksum="B725F936732E89BD" modified="2018-12-05" version="1">MSLDGIVTRALVHELRPCIGARIHKIYQPTEHELVLHIRGQGFGGRLLLSAHPSMPRLHFTQQPWDNPSEPPMFCMLLRKHMEGGVIEAIRQIGLERVVEIDVRHRDELGDYSLKRLTLEIMGRHSNLILMDPGTGVVHDGIRHVTPAISSYRVVLPGVAYVAPPSQDKRDPLEETEEGFRQTMETHAPADPKSAAQALVDSYIGISPLIAREIVFRAGGWQGAGALWNSFIELMQATLEHRYAPTSVETDDGKALFSATSLTHAAGEARSFDSMHECIETFYQGKAERDLVRQRTLDLHRFLANETAKNEKKLVKLQETMNEADDADRFRHLGELLTAHLHLIQRGDKTVEVTDYYDEAQPVISISLDPQLSASENAQRYFRKYNKLKNSKAVVEEQMEAARAEIVYLGSVLQGLEAASPRDIEEIREELTEQGYIRARGLKRGMKKKKKGTPTIVCYTSSEGIPLYVGKNNTQNDYVTNRLGQPSDTWLHTKDIPGSHVLIRSSEFGEATLLEAAMLAAYYSKARESSGVPVDYTRIRHVRKPNGAKPGFVIYDNQKTLFVTPDEAAIQKLAFSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTD3</accession>
    <name>A0A398CTD3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_05805</name>
        <name evidence="2" type="ORF">D3H35_19415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000026">
        <property type="protein sequence ID" value="RIE04519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02805">
        <property type="protein sequence ID" value="RIE02805"/>
        <property type="gene ID" value="D3H35_19415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04519">
        <property type="protein sequence ID" value="RIE04519"/>
        <property type="gene ID" value="D3H35_05805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="325" mass="34660" checksum="59D80549A6EDA122" modified="2018-12-05" version="1">MSAAEISNRSSKSSFNPPERRGGAIWLATMIALAGLWTSGSSIWLKGIAGWIVVAIAWTAVLRLRRELSAREASMALIGSALCWLASAGAGVAGMFVVWNVNPYTSVLSSLEIPFFVHITIDCAVIFAVLAITVWLWFLSAVVPTVARRTGGNPIRMVVLAASETRKNVRLWSMLPLTACIHLISWAVAASCGGAAQAIAGLANGWVELLLLAGLLRVSKFAPLAAPRQAADSTVTVVRGRRTALIAIAALNLLLFGFYCVLFISGGHPAWKVGLTYPLSIASGAVIAAISWLLGLFKPLYYVALAVIFLLVSILFVLLIFQQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTK5</accession>
    <name>A0A398CTK5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_08785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04038">
        <property type="protein sequence ID" value="RIE04038"/>
        <property type="gene ID" value="D3H35_08785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009372">
        <property type="term" value="P:quorum sensing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006741">
        <property type="entry name" value="AgrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04647">
        <property type="entry name" value="AgrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00793">
        <property type="entry name" value="AgrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0673">Quorum sensing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="179" mass="19815" checksum="797AA74B8EA85AD4" modified="2018-12-05" version="1">MVGVIHKLSYGIANYIKKSEPEATASVAVMQYSLYIILHSLFTAAIIFIIGAATGRFFETFIGLAFFVVLRLIAGGYHLHSSTLCTILSIALINAAPFVSMPDRWIPVVTIVCAIFVLIYAPRNFKGYARIPERYYPYMKIVAFAVVCSNLFWHSATIGFVSVLHTAMLVPQQKGGENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU26</accession>
    <name>A0A398CU26_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02821">
        <property type="protein sequence ID" value="RIE02821"/>
        <property type="gene ID" value="D3H35_19505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="123" mass="14040" checksum="66757327090A6E0E" modified="2018-12-05" version="1">MSQPSIPNITPLISISKDQTISLLLSSIAMDELALSHLINAEAEEMQAFVHHVGRKHHVHCREFIQFNDSVSQFMEGITMKQWIALKRLDRLIALTEDCSPYNNEPPIDKGDFIDEEFDDDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUI0</accession>
    <name>A0A398CUI0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_06710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04298">
        <property type="protein sequence ID" value="RIE04298"/>
        <property type="gene ID" value="D3H35_06710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="3">
        <location>
            <begin position="7"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="206" mass="24084" checksum="BE6378E1BA564748" modified="2018-12-05" version="1">MYRKYFKRVIDFVLSLIAIIVLSPAMVTIAILVRTKIGSPILFHQKRVGKDEKIFTMYKFRSMTNEKNENGELLPDNIRLTRLGRILRSTSLDELPELINILKGDMSIVGPRPLLESYLPYYTEEERLRHSVRGGLTPPEVLYNDFTPTWDKQLEYEVHYAKNVSFLLDLQVVCATIKGVLARNNNDYGSYIREEIWDIREKRKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUM9</accession>
    <name>A0A398CUM9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_11050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03567">
        <property type="protein sequence ID" value="RIE03567"/>
        <property type="gene ID" value="D3H35_11050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="61"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="255" mass="27460" checksum="7E4926B187BCEFDB" modified="2018-12-05" version="1">MVVKNGWLSLAAVLIAFAAWWAVTAAGWINPLFVPSPQAVWKAFVEICRDGYKGSPLMTHIGASLLRLGIAFAIALATAIPLGLISGHFAKARAIVDPFIEFYRPLPPLAYYTLLVLWLGIGNSSKIALLALAAFAPLYIAVVAGVVRVPQDRINGARSLGAKRLDIFTHIIFPSCLPDIFTGIRTSLGVTYTTLVAAEMVAAVSGMGWMVLDASKFLRSDVIFVGIILMGLIAVLIDGSIRLLERSRVPWNGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV48</accession>
    <name>A0A398CV48_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05159">
        <property type="protein sequence ID" value="RIE05159"/>
        <property type="gene ID" value="D3H35_01965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="471" mass="53212" checksum="5F9BE910ED65C26F" modified="2018-12-05" version="1">MSYKSDRSSFQERLDHFVNVIRTDIITGIRQDGTYLPAESSLAEQFQLSNKSIRKGLDQLVEEGLIVKIDRVGSMVTPRAKETITLNFGCSISLTTDFLIDELIAEFGRLNPGIHVRRISLNHLSYVQSAEEMISNGLLDIVAFNSPQFQEWTEADLAPLLEEIESDPELYPITEEAFEFDGALYAKPVSFSPVVVCYNKSHFREAGLHEPDSYWTWSDLLAAGEKLAKARGRHGIYFVPASENRYSVFLLQGTANTPGVHQAGEALPPKAVSALRTLNELVGNRDVFPNYLAQGNDETIRLFIDGQVSIILSTYFNLNEFAHLSSLDYDICPLPSLRKGDAQRTLLLTIGTALVRHSNSKEAARRFVDYLSSADAQNLIRERTVSIPARKKSAEMAAENGLKRPSRYSMFREMFPSFAYHRDIGLRMQDLRLFTRWLKEHWSDMLDEPALHEKLKELLAAGNERATEKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVQ2</accession>
    <name>A0A398CVQ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellar protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_11415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03291">
        <property type="protein sequence ID" value="RIE03291"/>
        <property type="gene ID" value="D3H35_11415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009384">
        <property type="entry name" value="SwrD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39185">
        <property type="entry name" value="PTHR39185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06289">
        <property type="entry name" value="FlbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="77" mass="8281" checksum="F3E1219B387D34DF" modified="2018-12-05" version="1">MIAVTRLNGTKFTINALLIETVEETPDTMITLTTGKKFIVMENSSDVIRSIRHYLRSIGVLAAITGPANAQSEGATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW06</accession>
    <name>A0A398CW06_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_19480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03204">
        <property type="protein sequence ID" value="RIE03204"/>
        <property type="gene ID" value="D3H35_19480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="420" mass="45653" checksum="63F1013D5046C155" modified="2018-12-05" version="1">MQDDRKAVKSWIMYDWANSAFATTIMAAVMPIYFVSEAIGGTDAGWGFTQTAAAIVIALLSPLLGAIADHSGNKKAFLKFFMFVGAAASILLAVPGKDDVLLASAIVILGMIGFGAGNTFYDAMLNDVASPGNRERISANGYAMGYLGGGVLLAFNIVIIQKPELVGLADSAAGSRISFISVGIWWLVFSIPLFRNVTETKKAAQERFGKKVREGLARLRVTFSEIRQYPELWKFMIAYWFFFDGVNTVIVMATSYGKTIGIDTGPLITALLLTQFIGFPATWLFGKLADKIGPKRMLYGSQAMYIVIVVLGFFMQNATHFYILAALVGLVQGGSQATARSIYSRLIPNGRAAEFNGFLSFTSRFFSFGGPLVFALVKVFTDSSRYAILAVAFFFVMGMLLLSFVNTAKGEREAEGRTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWE9</accession>
    <name>A0A398CWE9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_10860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03541">
        <property type="protein sequence ID" value="RIE03541"/>
        <property type="gene ID" value="D3H35_10860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="298" mass="33176" checksum="CA860766AF97F4E4" modified="2018-12-05" version="1">MNLHALKVFHCVARIGNVTKAAEELRISQPAVTQHIRNLEKELGVKLVRPEGRGIRLTFAGNEVYRLAGKITAAEHEIETRVKDLLDGTAGELTIAATYLPATALLPKCIALFKSDNENVNIKVVTGNSKEAFELLVNHRADVAIIGGGWERQHMRWEHLLDDELWFIVPAGHPFANRNVTLEQMMEETFVIREEGSSTRERFLSMCRTFNVRQPKIGMQFNGLQESIKAVSAGYGANVISAMAVQEFVAKGEVARVFVDGVDLKRPIAICTAEDQALTPITEKFVRLVREHLGKPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWN7</accession>
    <name>A0A398CWN7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdenum cofactor guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_12275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03434">
        <property type="protein sequence ID" value="RIE03434"/>
        <property type="gene ID" value="D3H35_12275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02503">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013482">
        <property type="entry name" value="Molybde_CF_guanTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="4">
        <location>
            <begin position="10"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="215" mass="23270" checksum="5B1573DB07FB63A7" modified="2018-12-05" version="1">MNGLAGTVTGAILAGGPNTGMDGRSKALLPFGNEPLVQRQIQAMQEICREVVVVTNDPKPFFRILDHSVRIITDSYSGSGPMSGVHAALRLARNPFVWIVGSDMPFISAEAAARLVMAGRFGNHFDAVLPVLGGKPVPLHGVYDTRCADKVQSTLEEGRGELTDLMGAIRWYGLPADSWERASEREGLAGSFAYSFDDQIEYERALELAFGSLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWU1</accession>
    <name>A0A398CWU1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_02565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05038">
        <property type="protein sequence ID" value="RIE05038"/>
        <property type="gene ID" value="D3H35_02565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="65" mass="6521" checksum="8F3EC7737F6ADA70" modified="2018-12-05" version="1">MPLPVPRWPMPSQSPCTVMPGASNATTGIAIGACGLSASSVGTECQNAHFAPGEPVANRLSPSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX89</accession>
    <name>A0A398CX89_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000035">
        <property type="protein sequence ID" value="RIE03614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03614">
        <property type="protein sequence ID" value="RIE03614"/>
        <property type="gene ID" value="D3H35_10770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="150" mass="16290" checksum="CC553B5C971A349A" modified="2018-12-05" version="1">MLATGGVEWPEEACRPAALNANGYAGIRFLLRLSLEGAQFMKELLVRDTWPVRAQAELELTGIAPRLPVKIAFDPPLLHRLLAELCDESGLVSRSALVQFFSKEPAAIGLTLDGEPGSSGELAETLADWVRSRYGSFAARLSPMASAIWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXK0</accession>
    <name>A0A398CXK0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03951">
        <property type="protein sequence ID" value="RIE03951"/>
        <property type="gene ID" value="D3H35_08295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="159" mass="16979" checksum="59EBC826D338FA09" modified="2018-12-05" version="1">MSLDLRRRRRGIGDVRDFSARRGGPCFHCLFPQPPAGGSLDTCETAGVLAPIVDTIASLQAMEAIKLLTGNEQALHGSLVQIDMWLNGWNSLSLAGARRPQCPVCSAHQYARLSGEHDEPLTASLCGRNTVQVVPHDGSTAGLTHGRTPEPGAVSARWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYE1</accession>
    <name>A0A398CYE1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copper amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_05060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04837">
        <property type="protein sequence ID" value="RIE04837"/>
        <property type="gene ID" value="D3H35_05060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017245351" evidence="1">
        <location>
            <begin position="29"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="175"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="432" mass="45903" checksum="3462E5533DD398E0" modified="2018-12-05" version="1">MGKWGKATLTALISLSIGASVPQGASEAAGSSAAASASVVNKVNVLLDDVALGFDSAPRIENSVTIVPFRTLAEALGINVQWEEKSQTVTATGTVNGKAVKVVLRVGSATASVNGQSMKLLTASVKREGRVLIPLNFFSTQFGAVVGWDSKTRTVSIVSPKREMHLRSFYALGSFKQRGLISSMNSVAFGWSRIDSNGEWVLDGADYNWPEAAGDITPESIVADASAAKAAPYLMVYSVDGNNELTRMLGDAKLRTRSIDSITKLVKEKGFGGVVLDFEGLGLKLDPLGQQKLLNDYVSLLADKLSTDGVKLSLAVPPPNGSYKGYDYKRLAELADDLVLMAYDYKAPGAPTAPEPNAKVDAAIALMLKAGVPKQKLLLGINLNSETPTTLDDKLGLAKRYDLKGAAFWALRYFGKEGMTEAMNASVTKKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZH0</accession>
    <name>A0A398CZH0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_03715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04611">
        <property type="protein sequence ID" value="RIE04611"/>
        <property type="gene ID" value="D3H35_03715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="135"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="135"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="237" mass="27028" checksum="F0D4975C400B18FF" modified="2018-12-05" version="1">MSTGNRILVVDDEERIRRLLRMYLEKEGYVIEEAEEGETALNMALQGDYDLIVLDLMLPGMDGMEVCSRIRQQKTTPVLMLTAKGEEVNRVQGFEVGADDYVVKPFSPREVIFRIKAILRRSSATAFLSKETHSSSNIVFPHLIIEHDAHRVTAGGFEVNLTPKEYELLHYLASSPDKVFSREDLLKDVWNYDFFGDLRTVDTHVKRLREKLNRVSSDAASMITTVWGVGYKLEVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZX0</accession>
    <name>A0A398CZX0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbonic anhydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04751">
        <property type="protein sequence ID" value="RIE04751"/>
        <property type="gene ID" value="D3H35_04520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="PTHR43175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="197" mass="22041" checksum="E5CB1714993894A3" modified="2018-12-05" version="1">MHKLEEILNFNQSFVENKEYEQYLTTKFPEKKLVIVTCMDTRLTELLPKAMNLKNGDAKIIKNAGAIITSPFGNIMRSILVALYELKANEVMIIGHHECGMTAIEPEVVVGKMTDRGVPDHVIHTLRNSGVNFNRWLKGFDSVRDSVVNSAKIVRDHPLLPPGTPVHGLIIHPETGHLELVSDGYSVEPEFDDLASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D147</accession>
    <name>A0A398D147_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon-nitrogen family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_04250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04894">
        <property type="protein sequence ID" value="RIE04894"/>
        <property type="gene ID" value="D3H35_04250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="269" mass="29848" checksum="574966550B47DFC8" modified="2018-12-05" version="1">MINSMNSVLKLAVIQMNIEAGNPDANYAKAQRYLDEAVAAESKPDVIVLPEMWNTGYALTEIQQLADPRGQRTKAMISEFCRRHAVNVIAGSISEHRGDGVTNTIYAFDREGKEVLEYSKIHLFQLMNEHLHLQAGDAAGAFTLESAPAAAMICYDIRFPELARKLALGGAKILFVPAEWPHPRLHHWRTLLQARAIENQMYVVSCNTVGESGGTSFFGHSMVIDPWGEVLAEAAEEETIVRAEVDLGLADEVRGRIPVFSDRRPALYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D155</accession>
    <name>A0A398D155_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_04745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04904">
        <property type="protein sequence ID" value="RIE04904"/>
        <property type="gene ID" value="D3H35_04745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="285" mass="31889" checksum="7AFEB50B9396CE54" modified="2018-12-05" version="1">MRVSAVQFRLRDCDGIDKFREQVTHYVRNASEYGTRFLLFPEFVTTPLLAIGATEGSGGQPVDKLLEYTDDYVSLFSGLAVQYDMYLLGGTHITRAEDGTLRNTAFMFGPDGSVATQDKLHITPTEKEEWNVSGGQSVQVFPTPFGTIGLLTCYDIEFPEIVRMVRAKGADVIFCPSCTDDRHGFYRVRYCCHARAVENQVYIVTTGTVGSLEKVDFMRANYGQAAVITPNDIPFPPRGILCEGEINADMLITADLDLTLLAEVREKGSVTTWRDRRTDLYTDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D181</accession>
    <name>A0A398D181_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PfaD family polyunsaturated fatty acid/polyketide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05251">
        <property type="protein sequence ID" value="RIE05251"/>
        <property type="gene ID" value="D3H35_01645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04742">
        <property type="entry name" value="NPD_FabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014179">
        <property type="entry name" value="PfaD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02814">
        <property type="entry name" value="pfaD_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="87"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="537" mass="58848" checksum="8D351B65CD899192" modified="2018-12-05" version="1">MQTMFRWTPGDEAPAFRPDEMTVLAARVREPAYIVRYGENGAFGLGLGGSAAPAIGSDAAGYPLAAMLPALYPEWLGDVSFRQAHGVRFAYIAGEMANGIATARMVIAMAKAGMLGFFGAAGLPLERVEMNLDDIQAELDPLGLPWGINLIHTPNEPAMEERIVDLYLRRGVRRVSASAFMGLTPSIVRYACSGLTLDDSGTIRRRNHLFAKISRPEVAGPFMSPAPRKILAELVSRGLLTEEEARLAAYVPLAEDVTVESDSGGHTDNRPLTALFPAIMRLRDDLQREYRYASPIRVGASGGLGTPAAVAAAFALGAAYVMTGSVNQSAIESGLSDEGRAMLAIAGLADVVMAPAADMFEQGVKVQVLKRGTLFSARGFHLLELYRSHNRIEDIPESVRLKLEKEVFQAPLDRIWEDTVRFFEKREPGQIERALRDPKHKMALIFRWYLGKASRWAIDGTPERKLDYQIWCGPAMGSFNAWTAGSFLEQPRNRTVVQIACNLLEGAAVVTRAQQLRSFGLPVPAHAFDFRPRPFQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CAP0</accession>
    <name>A0A398CAP0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II toxin-antitoxin system death-on-curing family toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00206">
        <property type="protein sequence ID" value="RIE00206"/>
        <property type="gene ID" value="D3H35_29665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006440">
        <property type="entry name" value="Doc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39426">
        <property type="entry name" value="PTHR39426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018297">
        <property type="entry name" value="Doc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01550">
        <property type="entry name" value="DOC_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="7"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="133" mass="15099" checksum="E997E8F974680C97" modified="2018-12-05" version="1">MSALRYLTVQEVIAIHIALIKKYSPGELIGVKDGGLLDSAILRPQSSAFGEDAYPTLFEKAAALFESIGQNHPFHNANKRTAFVALVIFLKYNSYSFDMEQKAAEDFTVDMVNHTYTFRQLAEMIEKQCRRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCI1</accession>
    <name>A0A398CCI1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00896">
        <property type="protein sequence ID" value="RIE00896"/>
        <property type="gene ID" value="D3H35_25315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="69" mass="8187" checksum="5283472EA5B3061B" modified="2018-12-05" version="1">MRYALAGTRMLSQALRASKWSMTEMLGCVCRLAEILEDSRHYALDFLFFCRTIFFVGDDWLDLRLVYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDD8</accession>
    <name>A0A398CDD8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Intimin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Attaching and effacing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_22630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the intimin/invasin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01196">
        <property type="protein sequence ID" value="RIE01196"/>
        <property type="gene ID" value="D3H35_22630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003344">
        <property type="entry name" value="Big_1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02369">
        <property type="entry name" value="Big_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00634">
        <property type="entry name" value="BID_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="SSF50985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51127">
        <property type="entry name" value="BIG1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017265511" description="Intimin" evidence="8">
        <location>
            <begin position="31"/>
            <end position="2046"/>
        </location>
    </feature>
    <feature type="domain" description="Big-1" evidence="9">
        <location>
            <begin position="485"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Big-1" evidence="9">
        <location>
            <begin position="586"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Big-1" evidence="9">
        <location>
            <begin position="877"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE01196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="2046" mass="215699" checksum="A2E8F6BC3536B447" modified="2018-12-05" version="1">MTQSRLTKWASICLTALLLFSILPVPFAQANSIHPSESRGYVQVDGGKEFTLALKADGTVWAWGYNGEGQLGNGTTTDSLTPTQVSGLSDITAIAAGDTHGLALKSDGTVWAWGDNVYGVAGYLDQDSNAYITIPVQVSNLSDVKSISAGSLYSLALKADGTVWAWGYNNAGQLGNGSDSREFTQVSTINNVVAIAAGLNHNLAVKNDGTVWAWGDNTYSQSGPSYSYHVNIPIKVNNISDAKGVAASKYYSLVLKTDGTVWVWGQGKSIPWQMKNNNGSSFSDVKSITAGSDNGLAIKSDGTVWEWSLNYYAQYSFGIYPELISTINDPITVSAGAGHSLAIQADGDIWAWGYNVSGQLGNGETTERQYVPLLALGTTDSALSDLSASVSRTSADGRSESVLTVKLTDKQGRPVQGHSVSLSQDGSSAITPLNGVTDAGGQASFIVVSTQAENVNYTAIDTTDQVAVMKSILVTFTADAVNTTNSRLTTSSTFLPANGTTSGTLTVMLRDKHNNPIPQRLINISQGEGNSIVLPISGGVTDLNGQASFLVRSTVAETITYTATDDTEQKAIEQTVQITFSPEALNAHVATESSNVEANGTDNTTLTVTLLDGAGTPIPGHVIALTQGSGISVIVPINGGVTDSNGQAFFTVANNQPETVVYSATDSTDQTTLAQTVQVIFYRDVTSVTLDQSELTLKVGKDSPRLKATVLPEGATNKRLIWTSSNPEVAVVGSDGLIMPLAAGTTIITVTTEDQGMTATSRIKVIGLTDRDGSTLTASASSVNVGSGFQVTLAVSLIDSLNRPMSGHVLVLSQGGGSSVITPLNGGRTNAKGQAWYTVTSTKAEKVTYTLTDMTDHVTLAQSAQIVFNAGLFDWMSSRVSVSHAQVEANGNAYSRVTVILVDYFGNPIPNEEVTLSQDDSTHSKIVPVNGGLTDANGVATFTVTNKYVETVMYSASVERLSNTVMLDRPRVYFVKGLATSANSTLTVSLPQVAADGISTSIITVTLKDSGNHAITNRKVSLSQGEGNSIISPEKEGYTDYNGQARFFVSNRKAETVTYTAHDSIDNTTFALSAEIRFTIGVANGVSSLFESSQTNVESTGESSSTLTVTLRDGTGNRIPNHLIRLTQGEGSSIIRPIQGELTDENGQVTFTVTNIKEEKVAYTAIDVTSKVTLERKVSINFYVNHVEGIMFDQSRMTLKPGDGTVALTARILPSNATNKTITWSSSDPAVARVDENGVITPLKAGTAIIKVVTADQHKEATCRIVVTQPAAGPASANISVTNNATGIEDIVTVKGLASGNTVKVYRELNDRIPIAQGTATIVPGTRSYESRVSIPQLGEFAGTVYVSVTSGSNESGKTPKSYAAEPSAKLSNGSVRIYNNLSPIKDSVVVSQLKIGDTVQVYKDNTTKSSLAKTTVTSAGDAQLFINQLGKTAGSIYVTIIKAGYSESERLEVSYNAEPSAGPSATAITVDNRLAAGSVGNVDSVSITGVTDNDVISVYDQLNDGTLLGSSVAGPSCTSASSKKICTVYLELPSHKAGTVYVSITKNGRESGRTLKAYLAEPSVPLNTDQLNSPDGDILIRNNYKTSSDSITVKRLSAGDVVKVFSAKLATLATSKPVANGQSSVTITLPQLGTREGTVYLSVIRSEYLESAKVVATYPQEAPQGLAISSIAVTNDRVEDTVRVTGLAIGDKVQIYSDVLTTDLLATGEAALSGIGSKPSALVSLQLPTGKAGKIYVTLTKEGIESSPTEKAYTAQPSEPVQDVVAINNLVKPDLVIVNGLAAGDVVKVYKDATPKSLVLATSNPVASGRTDITVSLSQFSKDLSAGLVYVSVIRKDYLESARVQVSYREAPPAAPLASVITVINRYGSSDTVTVSGLKMGDTVNVYSSARIGDDVLLGSSIAEQTGYGLFAAHVEVSLKPDSGSIYVTVSRNGIESDLTAKSYSPEPSAPLEDSQIEILDYMDNKLKDTIKVWNLSKGTIIKVYILEKNSWKPLLTSSSLVAENGAYSTTLKLTFPSQWTIKITQTVPGRTESDGIYYQLRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDK3</accession>
    <name>A0A398CDK3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_26695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00783">
        <property type="protein sequence ID" value="RIE00783"/>
        <property type="gene ID" value="D3H35_26695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="314" mass="34834" checksum="1C4FD033A894D089" modified="2018-12-05" version="1">MMNRKITASESGKKLHRLLRGLMPNLPLGQIYKMIDQGKVKVNGKRKNQNYELAAGDELSIYMEEAKYEEASVGQKKTKYIGVNANIDVVYEDDELLVVNKPAGMLTHPDQTDQKDTLINRVHAYLYRKGLLDSGLFMPASANRLDRNTSGLVLVGKTAGSLHRLNQSIQKREMEKFYVTLVQGRLSGEGEIAGALVREEGSNRTLVVGEKSGEKASGQEKEATTRYRALASGGGYTLVEVELISGRTHQIRTHFQSIGHSLLGDVKYGGKPFAGVNHQLLHAWRITLPDGKEFKAPLPQLFRDMMDKLGVSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDW3</accession>
    <name>A0A398CDW3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_26935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00820">
        <property type="protein sequence ID" value="RIE00820"/>
        <property type="gene ID" value="D3H35_26935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="134"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="344" mass="38365" checksum="CAE0B8DD3714838F" modified="2018-12-05" version="1">MCNKLRLGIVGFGRIVELVHLPIIKSIEEIEVHGVFDITLERRVLAEKRGFSVYASLEEMLRSPIDAVLIATPPNSHFSLAVQALEAGKHLIVEKPVTVNAREATKLLQLARKVGKTVTVFQNRRYDGDFLLVKKVISEGMLGEILFVERRYDMFGTGDFFGVKSFHPSWRNEFHFGGGALMDWGVHLADQLLQLELGQIQELTSTSENLRWGKSEAEEYVHANMKLTNGILMSMCVNFGSAARANSWVVGGDKSTLQVVSDKEAYLYRKGAAPELIQVPDTKRHAGKEIYMSLVNHIQNLGDLAVPLEQAVETMTLLDAIRYSKLCNRRVEYGDFAVGTADGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDX8</accession>
    <name>A0A398CDX8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_25420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00913">
        <property type="protein sequence ID" value="RIE00913"/>
        <property type="gene ID" value="D3H35_25420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="73"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="301" mass="34314" checksum="A704FBB2ACBB9728" modified="2018-12-05" version="1">MKRRITLENKREERAFWLFILPWFIGFLCFTGGPILASLLLSFTEYNVISSPTIIGLDNFKSLFHDRLFFKSLSVTLYYSVLSVPFTIITSLIIAALLNQKVRGQTILRTLYYAPSIISGVAVSFLWSWLLNPTFGVVNSLLYDWFGIVGPAWFTGPDTVVPSMVLMQLTASGGTMVIFLAAMQSLPTELYEAASIDGARKWRKFLQITLPLLSPVILFNSIIAMIAALQVFTESYVITKGGPDWNSYFYVYYLFDTAFKQFRMGYASAQAWILFIIILSLTLISLWSSKRFVHYEYDSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDY7</accession>
    <name>A0A398CDY7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Bifunctional protein GlmU</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">UDP-N-acetylglucosamine pyrophosphorylase</fullName>
                <ecNumber evidence="15">2.7.7.23</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="15">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">Glucosamine-1-phosphate N-acetyltransferase</fullName>
                <ecNumber evidence="15">2.3.1.157</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">glmU</name>
        <name evidence="17" type="ORF">D3H35_23800</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="15"/>
    <dbReference type="EC" id="2.3.1.157" evidence="15"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01396">
        <property type="protein sequence ID" value="RIE01396"/>
        <property type="gene ID" value="D3H35_23800"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03353">
        <property type="entry name" value="LbH_GlmU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01631">
        <property type="entry name" value="GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005882">
        <property type="entry name" value="Bifunctional_GlmU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038009">
        <property type="entry name" value="GlmU_C_LbH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01173">
        <property type="entry name" value="glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14 15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 15 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="16">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyrophosphorylase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="8"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="15">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="251"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="15">
        <location>
            <begin position="385"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RIE01396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="468" mass="49597" checksum="B03FAC412AE934A7" modified="2018-12-05" version="1">MKTMAIVLAAGQGKRMKSKLYKVLHPVCGKPMVSHVLDTVRAASCERAVVIVGHGAEAVQATLGESVEYAIQAEQLGTGHAVRQAERLLGDEEGVTIVICGDTPLVSTATIEEMLALHAKDQAAATVLTAELAVPAGYGRIVRGDDGGVLRIVEQKDCSSEEDAIREINTGTYCFDNRKLFQALAEVTNSNAQGEYYLTDVIGILQRQGERIAASLATDPSEAIGVNDRIALGEAEKLMRKRINTRHQVNGVTIIDPDSTYIEAEVVIGADTVVYPGSVLRGLTTIGSDCVIGPSADLLDAKVGSGTTIRQTVVESAEVGDDCSVGPFAYLRPGTKLGRHVKIGDFVEIKNAVIGEHSKVPHLSYVGDAIVGTNVNIGCGAITANYDGYNKSKTEIGDNVFIGSNSNLIAPVKVGSGAYVVAGSTITHDVPDNDVAIARERQVNKTGYADKIRARAKAKKERETKNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE26</accession>
    <name>A0A398CE26_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00685">
        <property type="protein sequence ID" value="RIE00685"/>
        <property type="gene ID" value="D3H35_27390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="66" mass="6942" checksum="E89D55E5A84961A7" modified="2018-12-05" version="1">MRAYGIGHPTVSPSATNKNFADEADIASWALEGVKAAAALGFVQGAERIASLRTGLQRAPKPRNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE54</accession>
    <name>A0A398CE54_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsF</name>
        <name evidence="8" type="ORF">D3H35_24165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01456">
        <property type="protein sequence ID" value="RIE01456"/>
        <property type="gene ID" value="D3H35_24165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020815">
        <property type="entry name" value="Ribosomal_S6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01048">
        <property type="entry name" value="RIBOSOMAL_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE01456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="96" mass="10994" checksum="0649E10F64A56852" modified="2018-12-05" version="1">MRNYELMYIIRPDVESESVQAVVEKFQGIIANGGEIVKHDLLGKKRLAYEINKHREGTYVLVHFKGTSAIVTELERVLKITDEVIRHMVVRDVVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEA0</accession>
    <name>A0A398CEA0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">smpB</name>
        <name evidence="5" type="ORF">D3H35_29515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00182">
        <property type="protein sequence ID" value="RIE00182"/>
        <property type="gene ID" value="D3H35_29515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="162" mass="18629" checksum="FC9C137B871F26DE" modified="2018-12-05" version="1">MGKKDQFDKPLAQNKKASHDYFIEDTYEAGMVLTGTEIKSLRNGRGNLNDTFATIRNGEMFLHNMHISPFEQGNRHNPDPTRARKLLLHKVQIHKLLGITKQEGYTIVPLKVYIKNGYAKLLIGVGKGKKQYDKRQTEAKRDSQRDIQRILREKQKVSIPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CET3</accession>
    <name>A0A398CET3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Four-carbon acid sugar kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_28600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the four-carbon acid sugar kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00382">
        <property type="protein sequence ID" value="RIE00382"/>
        <property type="gene ID" value="D3H35_28600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037051">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010737">
        <property type="entry name" value="DUF1537"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031475">
        <property type="entry name" value="NBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042213">
        <property type="entry name" value="NBD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17042">
        <property type="entry name" value="NBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07005">
        <property type="entry name" value="SBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SBD_N" evidence="7">
        <location>
            <begin position="32"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="NBD_C" evidence="8">
        <location>
            <begin position="302"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE00382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="482" mass="51679" checksum="92EB1591F4370A73" modified="2018-12-05" version="1">MRTRLTNEPQADRGEATAEAAFSGCRPAKLLCYYGDDFTGSTDVLESLFRAGVKTALFLEPPSDDRLRGRFASMDAFGVAGVGRSLTPEEAKRELRPIFETLKKAGAAVVHYKICSTFDSSPGIGNIAAAAEVGRDVFGDEYIPLLAGVPYLGRYTLFGNHFAAAGGEVHRLDRHPTMSRHPITPMKEADLRKHLAEQGEHSVSLMDILALDGPLPEVRERMRRRLELEKPDMMLFDVLDEARLETVGRLIWEEACRVEGRGRFVIGSSGIEYALGACWKSEGLTGSGTEVPTSVPSVDRLLVVSGSCSPITESQIDSALRAGFAGIRVPVDELLGEEQAAQARMRLLEEAKARLDEGKSVLLYSAAGPGDSSIELFRAALTAGGFRADDSSRLLGSILGSLARELIVGSGLTRLVVAGGDTSGYVTRELGLYALECAAALTPGGPLCRASSDDARLEGLELVLKGGQVGGVDFFERVRRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEW4</accession>
    <name>A0A398CEW4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_23020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01263">
        <property type="protein sequence ID" value="RIE01263"/>
        <property type="gene ID" value="D3H35_23020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009372">
        <property type="term" value="P:quorum sensing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006741">
        <property type="entry name" value="AgrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04647">
        <property type="entry name" value="AgrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0673">Quorum sensing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="81" mass="8377" checksum="B8A1C417A6E4C6A0" modified="2018-12-05" version="1">MILINALALKLAFQLKEANPNHPASLDVLRYAIASIINTAGTAIVAIILSLLLGHFSGAALALISFAVLRMISGGVILNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF81</accession>
    <name>A0A398CF81_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_21810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyltransferase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01065">
        <property type="protein sequence ID" value="RIE01065"/>
        <property type="gene ID" value="D3H35_21810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="39"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="382" mass="43897" checksum="5169372A62C6BE83" modified="2018-12-05" version="1">MYFLHRLEELFLLLLVYRLVLIPKRSGRCALREKKKINEINIVRAFAILAVLIIHATAGARSNVPWGSASSPFYITVNQLSTFAVPLFIMITGLVLFYRYYDNWTWEQALTFYKKRIQYIVLPYLIWSIFYYVYNQAVYNHEVSFDIEALSQQLLWGRAGYHLYFMVIIIQFYAAFPLILTLFRKMRLSARKVIGAGLLVQTVFYILHYWIGPFAHKAALMPNYFLVFCVGAAIGMSYQRFTELAGHLWWTFAASVAVGFTTVLIGLASRSGAHYWPPVYAVLFNLYAILVGFSALWIAQKLDARASAASKLANAFGALAFGIYLIHPAVLTLWRQIYNPDPQQSVYHLYNLASLMIIIIVPWAVAKLIKQSKHHWLLFGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFG5</accession>
    <name>A0A398CFG5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CitMHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D3H35_24210</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ArsB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CitM (TC 2.A.11) transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01463">
        <property type="protein sequence ID" value="RIE01463"/>
        <property type="gene ID" value="D3H35_24210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="12">
        <location>
            <begin position="16"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE01463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="426" mass="45921" checksum="6AA2EF90718545C5" modified="2018-12-05" version="1">MDHQAQIAIGIFLVIYALIISEKIHRTIVAMIGGLLVVAFGIVDQETAIHHIDFNTLGLLIGMMIIVSITAETGLFKFVAVWAAKKAKGNPVRILVALSLITAFGSAFLDNVTTILLMVPVTFSITRQLQVSPIPFLISQIISSNVGGTATLIGDPPNIMIGSAVKELTFAAFINNLTPIVILIMASYVPLFVLIFRKKIQTTPELTQSIMSMDSSRLITDRKLLTKSLSVLGLTIIGFFLHQSLHLESATVALAGAFLLLLLTGEHAMENALTKVEWTTIFFFVGLFVLVSGLVETKVISELAVKAVELTNGDPLATSMLILWMSAIASAFLDNIPFVATMIPLIQEMGNMGVTNLEPLWWSLALGACLGGNGTLIGASANLIAAGLSGKEGHPIKFVAYMKIGFPLMLLSVLMASVYIYLRYLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG28</accession>
    <name>A0A398CG28_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02166">
        <property type="protein sequence ID" value="RIE02166"/>
        <property type="gene ID" value="D3H35_15575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="126" mass="14172" checksum="9FFEBDFBDFDC29AA" modified="2018-12-05" version="1">MSEDRLCGIQLFQFNKEENLEPEAKKGDCPVCLLKIACGPNIGWGECALITDGRSVDLSVWGSFLQQLKKLTIAEALELLEQERPHWGETKTELVRKALTEIVLHRGQQLDVSALLARCRAYYSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGC0</accession>
    <name>A0A398CGC0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02266">
        <property type="protein sequence ID" value="RIE02266"/>
        <property type="gene ID" value="D3H35_16170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="215" mass="21134" checksum="97A28F24847D4084" modified="2018-12-05" version="1">MAGCGSKDDGNGGAAAAPTQMNNGGQQGAGGQNRMQADLLGKVKSVSGQTITVYKSSFTPGQGRPGGGANGGGNGQQPPADGNGQQPPAGGNGQQPPADGNGQQPPSGDGQSGGGRGGFNMDNMFTEETVDIQVTDATKIVKRSFENNQATETEIALADLKEGDVLNVDLKDGTQEAVTISLGNGGFGMGGGGMGGPRGQGNNQGQTQTPAASNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGG6</accession>
    <name>A0A398CGG6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_30115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000064">
        <property type="protein sequence ID" value="RIE00169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00169">
        <property type="protein sequence ID" value="RIE00169"/>
        <property type="gene ID" value="D3H35_30115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="79"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="174" mass="20169" checksum="D0D98A547B2108AA" modified="2018-12-05" version="1">MAFPIRLIRICFKRRLSPIICWEQKDLIHKSGKMDIEHEEFNLRYAIESVMDIFTPRLAKISIDLIYELDPSVPQHIIGDSLRLKQILINLIGNAIKFTSKGEIFVKISVDEHIKNDYKIRFDIRDTESGYQKTNFHSCSSLSQVDSSTSRKYGEQGWACHLHPIVELMNGGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGG9</accession>
    <name>A0A398CGG9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Meso-diaminopimelate D-dehydrogenase</fullName>
            <shortName evidence="10">DAPDH</shortName>
            <shortName evidence="10">Meso-DAP dehydrogenase</shortName>
            <ecNumber evidence="5 10">1.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D3H35_13660</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L-tetrahydrodipicolinate, to generate the meso compound, D,L-2,6-diaminopimelate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + meso-2,6-diaminoheptanedioate + NADP(+) = (S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13561"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58556"/>
            <dbReference type="EC" id="1.4.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the diaminopimelate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.16" evidence="5 10"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01833">
        <property type="protein sequence ID" value="RIE01833"/>
        <property type="gene ID" value="D3H35_13660"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047850">
        <property type="term" value="F:diaminopimelate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010190">
        <property type="entry name" value="Diaminopimelate_DH_Ddh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032094">
        <property type="entry name" value="Meso-DAP_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16654">
        <property type="entry name" value="DAPDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025648">
        <property type="entry name" value="DDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01921">
        <property type="entry name" value="DAP-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 10 11" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="12">
        <location>
            <begin position="5"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="DAPDH_C" evidence="13">
        <location>
            <begin position="123"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="36"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="70"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="93"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="122"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR025648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR025648-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE01833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="327" mass="35730" checksum="918C9973C563C841" modified="2018-12-05" version="1">MSAAIKIGIVGYGNLGRGVVSAIGQNPDMELVGVFTRREPASFGSEGGLTFLHVSDLEGYKDRIDVLILCGGSATDLPEQGPFFSKSFNTVDSFDTHAKIPEYFEQVNDSALTAGKVAVISTGWDPGLFSINRLMAESILSEGTDYTFWGKGVSQGHSDAIRRVQGVKGGVQYTVPVNEVIDQIRQGQTPELSTRQKHLRQCFVVAQEGADQEQIRQEIVSMPNYFSDYDTTVTFISEEELRRDHSQMPHGGFVIRSGVTGTNTRQIIEYSLKLESNPEFTASVLVAYARAAYRLNKEGASGAKTVFDIAPGYLSPKSAAQLRKELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGK5</accession>
    <name>A0A398CGK5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00209">
        <property type="protein sequence ID" value="RIE00209"/>
        <property type="gene ID" value="D3H35_29685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="331" mass="37856" checksum="74BECAB7910D4B71" modified="2018-12-05" version="1">MSKIETEIKSQFNELFKQSNMQRYVNVVKTLPDVNAAIRDCERLFSCGFLVGYNRAKEGIIYDPADVSREKETVRAQGVTYQTGQAIKVFFSSGISAGANSALTLKVAPEEIHQYSVKPMRFVVDKSLTAASQTAAKSAEAARRIAPPYYRFEYRSKVHYDLTDISSKPREVLNDSLLSYFSRAYKKAEEKIQEATGKITDRNRFSSLLADQSWNKKFVNAYLYKAFVNSLIINILQYPYNDRNRMKLEKQAEQLRLVYSELEKDLRSRGCGSDIIEFHKSLAGACDGRDFLASHESEILRQHVEQQSERSYESGISRFEMFVDSNMFGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGU5</accession>
    <name>A0A398CGU5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000060">
        <property type="protein sequence ID" value="RIE00299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00299">
        <property type="protein sequence ID" value="RIE00299"/>
        <property type="gene ID" value="D3H35_29335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="70" mass="8598" checksum="E69B487E570BF8DF" modified="2018-12-05" version="1">MENIEDIYPMSDIEQGMIYHNLINPESAIYHEQFVFPWKENYFSIDALERTLHYLVKKHSQLRYNLHRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHA5</accession>
    <name>A0A398CHA5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">U32 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00278">
        <property type="protein sequence ID" value="RIE00278"/>
        <property type="gene ID" value="D3H35_29875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020988">
        <property type="entry name" value="Pept_U32_collagenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001539">
        <property type="entry name" value="Peptidase_U32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12392">
        <property type="entry name" value="DUF3656"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01136">
        <property type="entry name" value="Peptidase_U32"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3656" evidence="1">
        <location>
            <begin position="404"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="838" mass="93743" checksum="42E077BBD7D09FD0" modified="2018-12-05" version="1">MDKSALRREDIELLAPAGDWECLRAAVANGADAVFFGVEKFNARARAHNFQTGELPEMMKFLHRYGVKGFLTFNILVFEDELPDAKKLIEACIDAGVDAVIVQDLGLVKMIREISPDFPIHGSTQMTITSPEAVEFTKPFGLERVVLGRENNLKQIRQIGEQAKLPMEVFVHGALCVSYSGQCLTSEMWGGRSANRGECAQACRLPYDLMVDGVHQPMGDIAYLLSPKDLAAIDIVPELIEAGVASFKIEGRLKSPEYVANVVGKYRREIDKYFAGDESEPSEQEIRELQQSFSRGFTHGFLDGTNNKLLVEGTFPKSRGVYLGRVEKVLRDAVVCRIEAPLKRGDGIVFDAGDPTKKEEGGRVYDVRRSGVKLEGEAPQGDLIEIVPGRNDVDLSRVREGNRIWKTSDPALDRRLRSTFETEKPYRTFPTAVSVFGQEGSPLRTIWTDLSRGTTVAVESEMPLERAEKRPLGHEILSEQLGRLGGTLLHLEKLEVSLKGDVIVPKSELNRIRREAAEQLELLREAPPKYVKRELADVYADSPAEAETVNGKDVRLTALCRTLEQVKAAVKTDVAMIYADFEFIKQFPDAIAVCREAGKPIALATPRIHMPGENGYHRNILNLKPDAVLVRNTGALYYYLRERMAKPDAEHPLLIGDFSLNVANHKTVSLFREAGVDVVTPSYDLNIQQMVDLLRRADTSHLEVVIHQHMPMFHTEHCVYCTFMSEGTNYTNCGRPCEEKRASLQDRIGMSHPVRVDEGCRNTVYNAIEQSGAEYATTFLELGVSSYRIEFLEENADKVREVIGLYRAAFEGRISGTEVWRKLKAINQLGVTRGQLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHD1</accession>
    <name>A0A398CHD1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_28145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000054">
        <property type="protein sequence ID" value="RIE00489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00489">
        <property type="protein sequence ID" value="RIE00489"/>
        <property type="gene ID" value="D3H35_28145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="156" mass="17556" checksum="8EDDABF6BA65CFFE" modified="2018-12-05" version="1">MLNYFLSWFQPSMLDSEWLSDPHRSLLIVAIAEGYKFAAVYMVIFYSALISISEEVIEAARMDGASGWKLYRYIKLPMIKGIIFTSIILVLNGSLKSFDIPYLLTYGGPGTSSELVATYMYKQAFSSMYYGYGSAIAVFIAVECFLWSDSLCKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHF4</accession>
    <name>A0A398CHF4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA replication initiation control protein YabA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01412">
        <property type="protein sequence ID" value="RIE01412"/>
        <property type="gene ID" value="D3H35_23885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010377">
        <property type="entry name" value="YabA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06156">
        <property type="entry name" value="YabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021439">
        <property type="entry name" value="DUF972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="122" mass="14106" checksum="E3DC09BCEEF80A94" modified="2018-12-05" version="1">MKDIYLRMDELESHLGTVHADFGELKLKIKELLEENQRLRIENQQLRKVLKRETDSNIARAEAAKEPVVLSKEDKPVSLPGVGEGYDNLARLYHEGFHICNVYYGHLRMEGDCLFCLSFLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHI6</accession>
    <name>A0A398CHI6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_28645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00388">
        <property type="protein sequence ID" value="RIE00388"/>
        <property type="gene ID" value="D3H35_28645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017469275" evidence="1">
        <location>
            <begin position="35"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="295" mass="32353" checksum="0436FF57D98F2304" modified="2018-12-05" version="1">MAQPSTRRLRAFAAAAFLSLVVSLLPLSAVHAGSDGHAGKLDAQVKQWVAELSRQSAFAAWEKAVPEIQPIGPGTHGWLVTLSANGKPVGYLVVNAAEDGTFQLGEYGAGPDVLFSESLLRQALKENGLLLEDAGRAVPVTVARHYAHPLAAVWEVTAGEDTYWLDAKTGELIPIDGKAWNSKFGTATYKPPTVSNAVKVASLTIRETFDPYERLPWLLGDKPFSVRESEKVQNRIRSNLHLRYVSEPFGDAMLYALPVVGFQRWTSGRLDLALDMQGTRFIPMDTLSRFGLFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHJ5</accession>
    <name>A0A398CHJ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_28720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00398">
        <property type="protein sequence ID" value="RIE00398"/>
        <property type="gene ID" value="D3H35_28720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="255"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="508" mass="56015" checksum="75749C1BF30D7385" modified="2018-12-05" version="1">MALIVIDLGTSSVKVALYDHETGEILSTGRGHYRLYSEKQGYAEQNPEEWWTQTKYAIQECLHRAKISPKSIKGIGLSGQMCGVVPVTKSGQPLYNCITHLDTRCVEEIASLRERQEDVLRIGMNPITNLMSAPKLMWLKNNRKDVWDQAHKWLMPKDYIRLKLTGTFGTDSTDASATLFMDFNKKTWDPLIEHFGLDITKFPEVNLPYELVGSVTKSAAEETGLAPGTPLAAGAADMACTALGTRAVSEGNISVTIGTAGHLIAPIAAPDPAYAGRLYQFCHAVPDMYYAFGSIPAGGLSLSWLIDLLNPLLNDEPGNNRKLTYEKMNRMAEESTIGSKGLFFLPYLAGSVVPYADPKAKGTFIGLSIRHSYGDMARAVMEGVAYNFRQIVELLDLCNIPAHQLFFGEGGMNSQIWTRILTSVMNRGNAFLMKDKDSAPLGAAIIAGMGTGLYHDWNDAVNKLSQVETVPNDLAMAESYSKLYRIYEGLYPTLKTTFEQIYDMEGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHV3</accession>
    <name>A0A398CHV3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01592">
        <property type="protein sequence ID" value="RIE01592"/>
        <property type="gene ID" value="D3H35_24925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="75" mass="8729" checksum="7162379DB39358D3" modified="2018-12-05" version="1">MRKKVVVKIPMLLKKHGISLRELSRLTDIRHAALSELSSQKRQNINFNHIEKIAEAFDIHDIREIIDLKSNGQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIA0</accession>
    <name>A0A398CIA0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_15155</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02095">
        <property type="protein sequence ID" value="RIE02095"/>
        <property type="gene ID" value="D3H35_15155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="780"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="820"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="869"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="43"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="803"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="906" mass="98034" checksum="F604F10CE96BDB62" modified="2018-12-05" version="1">MILPIAAVALALMLIYALGICIRFPHIRRIAAREIAQSKMAALLTVAGLSVGIALITLVVSVRFGIEGSEEDYHRQHFGPIVAEAPAIEQPLLSNPYFSSDEMRTMLESAGDSSSKLLPIVSYAVTLLPSSSVSGERRTEPLSNVLVIGTDLTEAMRWDPALSGTGLLSTRLGADRIVLSRTAAERLSVQEGDTVLALDLNNRAISFEVEKVVREAGLTGYRGYQLADATAIVDSDSARKLFGLPAGSYTSAVGSTFPRPPWTSESVKAGAMQSLSFSPFYATSFFGIIQMNAILMSLILTINLFRLIVEERKRGMLVLRSIGFSRLDLKRIVRLEGLGYAVMAGLAGGAAGIGLSSWMLRSVNAYTAVDSGLTLRISGPTSFKALLVGVSIGIGVVFVCVWLVSQLTLSRSLLTVAAVELGGKRARSSRSETFHTWFALLSLVYSLLLVLLLAVPSVRRDWFVGVDLFDWGIGIGVLLPVVVYSGVRWLEWGCRAALMLLRRATALAGILNLVARQLQSNRLRSGLLILLFACVTFFSSFSQVISVYIQEVLVRYDARADMGGYDYYAEDIRPATSAQLERYVQQAGFSQDESPVVASVLRLPWKESAYRKLPIHGIDGSYAAATTLEAAPFSERSPSDPWREVAEDKDAIVVSAAALRFMNNNGWKPAGDEAAFDLNGSKVKKRIVGVVEDSEYAYPGTSGVWLNAGELMALGQGQKELHSIFFLRFPSISIAKELREKTAQALGKSNVPTLRSAADYEVGYMANIGSQLVLFERFNLLALSIGVAGLSVVMLRSSRMRKDQLGMLRAIGIPPAHLRLYLWLEGALTAAFGTALGFGAGAYSAFVIIEPQTLETPEGFLFSFPAERLIATGALVILVIVVATFWTARSVYQVSAAAATRNHTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIG0</accession>
    <name>A0A398CIG0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01842">
        <property type="protein sequence ID" value="RIE01842"/>
        <property type="gene ID" value="D3H35_13715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="214" mass="23825" checksum="77ADEA54BF3F7F9C" modified="2018-12-05" version="1">MSELETLVTNRRSAMNFVEGVDIPESEFEAMFSLNKFAPSAFNLQHTHYVVVTDPEIKDKVYLAANKQHKVKTASAAILVLGDPKAYRQVGALNEGMLALGVMSKLDYDLEVENVTAFYESRGERFQRDEAIRSASLSAMQLMLIAKDRGWDTCPMIGFDPQAMSEALDVPEPFVPVMLITIGKSDTAKIRPRGYRKPVGQQVNYNRFGGSSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIK1</accession>
    <name>A0A398CIK1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02563">
        <property type="protein sequence ID" value="RIE02563"/>
        <property type="gene ID" value="D3H35_17910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="51"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="164" mass="18470" checksum="3A9DFF72CCFE967A" modified="2018-12-05" version="1">MPYAGTAVDFFSNPSTAYAATPGSSALSKIQKNQSIIEGIIAKDAKYGAKYTVYELYEVDKDGKEKVKYVGRTRQNINERLTQHEKSDPNKKGLETRIAEQDGKRLTGLTYSEGRGLESVVYEKRIKQEGKLLNRIKPIDLSELGKETKKGMKAAEYLKKLRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIL9</accession>
    <name>A0A398CIL9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage tail assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02583">
        <property type="protein sequence ID" value="RIE02583"/>
        <property type="gene ID" value="D3H35_18030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="126" mass="14475" checksum="93FAE0A2156FB1CA" modified="2018-12-05" version="1">MAFQTEYEFELPRGYVDEQGTLHKRGVMRLATAADEILPMKDPRVQSNPGYLSVILLARVVTKLGDLRHIDTRTIEKLFTADLTYLQSLYRHINEMEPPKLHTACPKCDHEFEVEVDFLSVTEGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJY1</accession>
    <name>A0A398CJY1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fused response regulator/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_18175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02610">
        <property type="protein sequence ID" value="RIE02610"/>
        <property type="gene ID" value="D3H35_18175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="385" mass="43664" checksum="CF20B59F74648979" modified="2018-12-05" version="1">MRVLIVDDNATNIMVVQEMLKRAGYEKISTASSAKEMFDVLDGTFDPSSYSPPKIDLILLDLMMPVMDGIEACRIIQTDARYRDIPVIMVTAIGDSRKLAEALDAGAIDFVTKPINKTELLARIRTALRLKRELDWHKEHDRKMQEELTLARKVQESVLPDDMEGDVIRAKAFFRASEQLAGDLYMWHRIDEGRWCFAVIDAMGHGLSSSLVSMFVASVLKEAMRTLWSPERVFRELNRRLLSLEFDHELITYYCTGIYATIDLERGRLEYANAGHPPGLLYKRGKTNPIRLGTTSAPLGMFDSMQPQSDVIEIESGDKLYFYTDGVLGPFPGDDLAQIDRLAEFLLQSSEDEDSVDQLIQCQPLDGRSDDRCLIKIEVVRERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK23</accession>
    <name>A0A398CK23_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.14</ecNumber>
            <ecNumber evidence="2">4.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">eda</name>
        <name evidence="2" type="ORF">D3H35_17505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.14" evidence="2"/>
    <dbReference type="EC" id="4.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02492">
        <property type="protein sequence ID" value="RIE02492"/>
        <property type="gene ID" value="D3H35_17505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008700">
        <property type="term" value="F:4-hydroxy-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="223" mass="23482" checksum="29F907B1B0BA551A" modified="2018-12-05" version="1">MKKLKIVQQIVNEGVVAVLRGKSAEDVVAMAEQAIAGDIKVIEVTMTVPFALQAIETLAKKYSASAAPDSDRYAIIGVGTALDPETARAAILAGAEFVVGPSLNPATVALCNRYRVPIMPGVMTVKEIQEALELGVDICKLFPGNLYSPSTISAIKGPLPQANLMPTGGVNLANLGDWIRAGAVAVGIGSDLTNEAVKTGDYELIRRRSAEYIDAYRKAKGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK94</accession>
    <name>A0A398CK94_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_23225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01298">
        <property type="protein sequence ID" value="RIE01298"/>
        <property type="gene ID" value="D3H35_23225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="677"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="967" mass="104346" checksum="2F8E72EC0D55CA27" modified="2018-12-05" version="1">MATVSSSLQMFAQVSQTLNRAQKEIQRALGLARRLQQQLQQRMAVEIDTSGALSQLDGLKDRLESSFGETVVFNIFFDTGGIVQDYARVQQLLQTNLPVVEASIELYSEGAILDAEEARERIRSVTGQFWAIINVGPPEAGEIRTRLLTVLQVLNPAVTVRLVFDEIAANEQLHETINRIASTEASVKLTIDIGGVLAEVEQLRQHIASSGFSSIRVVLDRAMVEVALDSTQALSQAASVRVRIERQIGTVHAEVKITAVETSDFRNQIRTRLKGFTVKIKASLDTSQALAEMSALRGQLMAGIGSIRTTIQIQLPAALTVMFTNIQRLVMRLIAAVGRLRSAGIQLNGANRSARQSQDTPNQQKSEGKSEAGGLQARINGLLSAYQTLQDVGGFLSSSFGGAMDQLNLAEMFKAGTGSGDIGTAMFEKFKADAMAAGQDVNESLKGTLSFFSITQNTDQLTKLNSLANRLSAFDLEGGGIESAANVLKEAMSGDVGALSERFNMPQSSVQSFKIEELAKAGDMDGFLSAFDQLMEKQNMGQAAFDGMMDSPAKQMEALGNNMKTTLNDVGAAALTSLAPLIDKVNEFLQSGQITDFITNNWSAIETAIIGVTSALALWKIATIASNVALGIQNLLTTISAARSAYSTGATLAQVAATELATGAQIGFNAALLANPMTWIVIVIIALIAGIVLLVRWLINLWNTNDQFAGGLMQAWNMILNFFDQIPIFFTMVGNGIVNAFQSAGVLALQAIEAMINGAIDAINWLSETSNKILGTNFQIIQPVQISVQAEARAKAIKQAGIDEVNKMKQDAAAKAASREADRLKMLDDRKSKRALEQAEKAAKEQEAKDKAAPPDFSKWNQSHPANLNKAKTNETNGFSNQGRSANINRVNEVGTIGDKVEISSEDLKAMRELAEMKNIQNFVNLTPQISFGETHVRNESDIGTIITGIKSYLEEEFSSSVQGVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKB3</accession>
    <name>A0A398CKB3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01318">
        <property type="protein sequence ID" value="RIE01318"/>
        <property type="gene ID" value="D3H35_23340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="115" mass="13123" checksum="CEF6EE82E7B2D0A8" modified="2018-12-05" version="1">MASNDELTVPQEDLAQAWQRTLPERLHGGDKAEVLADGADPQTLRVHIQSAGHQMLDFDFSVQYVDSREIHVELTDVEKDGQTVDERNDTIQELIADYRRHLHECAQALHHFTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKJ9</accession>
    <name>A0A398CKJ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_13045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01729">
        <property type="protein sequence ID" value="RIE01729"/>
        <property type="gene ID" value="D3H35_13045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="181" mass="19304" checksum="DA25A096D9744F91" modified="2018-12-05" version="1">MKSILSFNLSDPAATGFIDDEAFAIFLTVPQGTDVTALKPAFTTDERTAKVKVNDVVQVSGDSAQDFTQPLTYTVEALDGSTRNYTVTVSMQRELSTAKEITYFGLASLSSVGTIDEINHTIALTVPFGTNLASLVPAFTSTGTGVYANGDQQISGKPLLILARLLCMSFMMKPAALRPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKY8</accession>
    <name>A0A398CKY8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Replication-associated recombination protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_27855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00557">
        <property type="protein sequence ID" value="RIE00557"/>
        <property type="gene ID" value="D3H35_27855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="50"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="435" mass="48289" checksum="E5063407E844E8FA" modified="2018-12-05" version="1">MDLFSYREEAEPRRRLLADRMRPETLDEYIGQEHIVGQGKLLRRAIENDAVTSILLFGPPGCGKTTLAHIISKQTSGDFVRLNAVDASVKDVREVIEQAEKNKNMYGRKTILFLDEVHRFNSARQDALLPAVEKGIIVFIGATTENPFHSINGALLSRSTLFRLQPLTKEHSLAAMRRALEDPVKGLAFMKLSVDEEALDHIASMANGDIRRALTALELAAVTTPSQPDGSVRVTVEVAEESIRQPTVIADESTQYDVLSAFHKSVRGSSDAALFWFLYAVEKLGMDPMTFLRRLTVACSEDIGLANPQAMVQAVSAMEAYHRIGWPESKYIAAQAILFAVESPKSNAVATAIGRITTTLDQAKSAEVPLHLRDGHYSGAAKLGHVGYQYPHDFPGHYVDQNYLPDKLQGAVFYEATEQGTEDKIRQNQARRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL41</accession>
    <name>A0A398CL41_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02912">
        <property type="protein sequence ID" value="RIE02912"/>
        <property type="gene ID" value="D3H35_20075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="160"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="412" mass="45707" checksum="B93B92597BBD1E9A" modified="2018-12-05" version="1">MHTFGIGAMFEACPPLRESGNVGLIGLSLEGGLAERITAESSEEPVLWQQWLTQTLEGESVKYANRIGRHLWLYAEVPGSTGANPDSYIDGLARRLKDELTVEMSISAPAGNGFVRGNGAGFGTAVIRVADRRKLDEKLYEAFLAAAARLQSDEGRSDPFSVQRAEMERLLKDQGIRSVYQPIFQLKEGQVFGYEALTRCPPGSPFAGPLEMFRFADREGYAFALDRKARETAIRSCPLLGARQKIFLNVNAGIMKDPGFVSGQTMQWLAERGLKPGQVVFELTERDSIDDFEEAKKTLGHYRSQGYEIAIDDAGAGYSSLQSIVELRPDYIKLDKSLVQRADEDDMKKYMLGTFVRFAKRMNIRTVAEGIERPEELRLVRTMGIDFAQGYLIGRPSERPALAFAAGLPRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL80</accession>
    <name>A0A398CL80_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galE</name>
        <name evidence="10" type="ORF">D3H35_09185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04106">
        <property type="protein sequence ID" value="RIE04106"/>
        <property type="gene ID" value="D3H35_09185"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="9">
        <location>
            <begin position="2"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="330" mass="36478" checksum="624501B1DFF3B49C" modified="2018-12-05" version="1">MILVTGGAGYIGSHVVKQLLDLGFEVVVLDNLSTGHRQAVDARAEFVKGNIQDELTLDWLFDTYPIEGVMHFAALCLVGESVVQPLKYYENNVAATTLLLKAMARNRIANLIFSSTCATYGIPEVDILHEELPTRPVNPYGRSKLMVEHMIRDLADAQPFPFVCLRYFNAAGASPSGTIGECHDPETHLIPNVLLHLLEKKTDVSVFGDDYDTPDGTCIRDYIHVDDLANAHILALQRLLRGDKTAAVYNLGTGTGYSVTEIIGACESITGRKANVIHAERRPGDPDRLVASYEKARSELGWSPQYSLEDMVRTAWKWHLRHPGGYSADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL88</accession>
    <name>A0A398CL88_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IucA/IucC family siderophore biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_22540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IucA/IucC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01668">
        <property type="protein sequence ID" value="RIE01668"/>
        <property type="gene ID" value="D3H35_22540"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="PTHR34384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IucA_IucC" evidence="3">
        <location>
            <begin position="116"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="FhuF" evidence="4">
        <location>
            <begin position="383"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="570" mass="66365" checksum="A0ADD90F8115CC26" modified="2018-12-05" version="1">MRQTMEALIFEGIVDVVKKERKWSFSGKTAEGVLIHYSCEADEKRSFGRVKIVKNSIRREERECSDLYLFLEEVIQNRLDGALTASFIHELLETLAKDRQSREFQPDRIPEQDRHYEALESHMTDGHPYHPSYKSRIGFSLADNYAYGPEFDQEVSLHWVAVDERLVDVSISGENSFDDIYKQHLTDEDTRKFNRIVQEKGSGDKKYVFVPVHPWQAERLLPSVFVQQLADKDIVPLGASNSPYRAQQSIRTLARRDNAEAAYIKLALSITNTSTSRILAHHTTQNAPLISDWLNKIVRNDPLLAKERFEILREMMGISFRYDALPSIPYRSAYGTLGAIYRENVSTYLEEREQAWPLNALLLTQKNGESFIQEAIDRHGIEKWSDALIRTVTLPIIHLLYAHGIALESHAQNIILVVEEDFPTRIIIKDLHDGVRYTPDKLLHPEWAPKLNPEPETHRKFNRYSFIQTESVSEVRDYTFDAFFFICMSDICWTLEKFGLSEADFWRKCTDTIVSYQNEHPEYKERFEMFDLFSEDSLIEEMTKRRIYGDGELYFRKANNPLLLAKDVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL97</accession>
    <name>A0A398CL97_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine-type D-Ala-D-Ala carboxypeptidase</fullName>
            <ecNumber evidence="4">3.4.16.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">D3H35_23365</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01678">
        <property type="protein sequence ID" value="RIE01678"/>
        <property type="gene ID" value="D3H35_23365"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015956">
        <property type="entry name" value="Peniciliin-bd_prot_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012907">
        <property type="entry name" value="Peptidase_S11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037167">
        <property type="entry name" value="Peptidase_S11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07943">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00936">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69189">
        <property type="entry name" value="SSF69189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBP5_C" evidence="15">
        <location>
            <begin position="336"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="12">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RIE01678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="460" mass="50233" checksum="454ECB1F9E50B7F8" modified="2018-12-05" version="1">MIQLRDAIGYKGENVLNYRHHSLIRRLPVFSKRIIASVALLSVLSTSLLLSSASAAATNAGEPQINGTAAILMDAASGQVLYQFKADDPHPPASMAKMMTEYLVIKAVQAGKITWDQEVATTENAAKQIGSRIFLAEGDKHTVKDLYIAMAVGSANDATAQLAEVVGGTEEEFAKLMNDTAKELGMTHSRFINATGLDRADMPAAYQPTSIDGETEMSARDSAILGYHILKETPEFLDYSKMPNFQFREGENQLIDNWDWMLESNLTSKTKKKFAYKGVDGLKTGHTSRAGNNFTGTALRDGTRLIAVVMGVPGGTNDGKRFLETAKLFDYGFNNFEKKTAVEAKKAVPEHETLKVKKGKSKKVNVITATDVSFLVPKGATVEATVKEVKSETLKAPIEQGAKVGTVTYEYKDPATQEMKSATVDLVAAEEVKKGSWWRLFFRGIGNFFGSLFRGIADLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLC9</accession>
    <name>A0A398CLC9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GMC family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_27220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00657">
        <property type="protein sequence ID" value="RIE00657"/>
        <property type="gene ID" value="D3H35_27220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="5"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="3">
        <location>
            <begin position="216"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="5">
        <location>
            <begin position="504"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="568" mass="63029" checksum="79DBBC2A311F15D6" modified="2018-12-05" version="1">MYDADVIVIGSGGGGAVAAKELGESGLKVLVLEAGPFYGNKQWQHPNSERGGEWSSRYDDLDVGIYKRIYNMYENNMNDVVSGTFRFGPADRRRTPWHRVMRQKGDIWQAAGVGGTTQHYWSQSPRAFPAAIDGIWPISYNELIPYYEKVEATLPVQFSPTTPKEELFYYGVKKAGWTLIPTLNVTTPGYRPNPNAILPVNPHLMDTRYSMDQLWNMEGCTLQGHCVNGCTAGPSMDKIAKRSTLVSYIPLALKTGNVAIRPNSFAIQILTEQDPKEGLRASGVKFRDTWTGEIHELTARSVVLCGGCIETPRLWLNSGLPFNSWVGRGLTNHCFDWVGGVFDEQDLMRIMGEPAVYPYVGHTSGARVDIPGTGIFQVSCLSPGIMSFLTYGFSEAGYSALNPSAPGEPWNIRGRVVGSALKELMRNYARTMTYLLLTDDETLYSNRVEVDPILKDENGPVPVVYYTPSPKTLQRRDRLARHACHSLKAAGAKTIIRSDTPFSFMLHLESTMRMGYVVDTNCEAYQVKRLFIADNSVHVNGIGGPNPTLTTQALATRTSEKLVCLYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLI2</accession>
    <name>A0A398CLI2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR03943 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_12150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03523">
        <property type="protein sequence ID" value="RIE03523"/>
        <property type="gene ID" value="D3H35_12150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015402">
        <property type="entry name" value="DUF1980"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40047">
        <property type="entry name" value="PTHR40047"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09323">
        <property type="entry name" value="DUF1980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03943">
        <property type="entry name" value="TIGR03943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="333" mass="38182" checksum="F433519E399014C1" modified="2018-12-05" version="1">MSRFCILLGFTVMFISLHLSGNLNKYINTKYSYLSIIAIVILGILCLVQFEAMYRKEKEEEKKKAAEALKAEGSKDEGTHEPLHENSHDHSHDLACDHEHNHNHEHEHSHNHDHDHFGHDHGHSHGSSSGWKRAISYVILIVPILTGLFLPVQTLDSSFVKAKGFSFPDFDASSDNPGQHQFLKPDTSVYYGDENYQKVKNRELAEFVNRESVKLSDEEFLKGMEVIYNFPGNFMGKTISFNGFAYKGEQADGNHYFIFRFGFIHCVADSGVFGMLVDFPKNAPAFSDDDWVHVEGKLTWEFYQPFKQTIPVLKVTSWEKIDEPKDPYVYRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLN3</accession>
    <name>A0A398CLN3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_26500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00747">
        <property type="protein sequence ID" value="RIE00747"/>
        <property type="gene ID" value="D3H35_26500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="104" mass="11961" checksum="DC43EE3273F787D7" modified="2018-12-05" version="1">MQSRFHPMFYVLIPLAALGIAQSFESLLSAMFIPIAILLVLYVVYLLSPQGRARKPRYRGPSYPSGPSRFRQPDRAKPKQKRSPSPFRVIEGKKDKDDDTPRYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLP4</accession>
    <name>A0A398CLP4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04266">
        <property type="protein sequence ID" value="RIE04266"/>
        <property type="gene ID" value="D3H35_06525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017190418" evidence="1">
        <location>
            <begin position="23"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="137" mass="15673" checksum="87707D32F2F1CF30" modified="2018-12-05" version="1">MRKFIFVTLLSLFLLSACSSQKKYSSVIEAIKSEGINITQMESSMEVELDGIKSLSYNFDNNEIIRVYDFGSKEKRELGNKHFQEHQQILSSHAPIVYQTSSYLVLYYSNANLTTATPKLTETKYGERIQKAINSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLY6</accession>
    <name>A0A398CLY6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferric oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_15735</name>
        <name evidence="7" type="ORF">D3H35_25985</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000045">
        <property type="protein sequence ID" value="RIE00867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00867">
        <property type="protein sequence ID" value="RIE00867"/>
        <property type="gene ID" value="D3H35_25985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02191">
        <property type="protein sequence ID" value="RIE02191"/>
        <property type="gene ID" value="D3H35_15735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="194" mass="21634" checksum="3DC3C2AC88400B55" modified="2018-12-05" version="1">MTDWLMQLPTWVITRVAGLSAFYLLTIGVVSGIFCGSPGIKGVWKARIFRFHSWTQGFGLIVAIAHVIVLAIDRYAKFDWITLIIPFSAPQHRLEYGLGSLAMYGLLAILLTSDFRGLLANRIWKTIHMTAYPVFFLALIHGLFSGTDSAKPLVFWSYAAAALLVVAATVIRALTEMNKTREKRAAPIRRQPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLZ2</accession>
    <name>A0A398CLZ2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_11180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03262">
        <property type="protein sequence ID" value="RIE03262"/>
        <property type="gene ID" value="D3H35_11180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="333" mass="34890" checksum="27111BD5375DAC80" modified="2018-12-05" version="1">MSNIHGSSFRYPEVWRPADPAEAWQWKRRFGAEAAFAAGATWLRTQWEAGSLPMPSYLIDLSAVKELTGIKVKHNRLTIGALTSLAQVRSSAEVLANAPALTAAAAAIAAHSIRQLATIGGNIVTRVGDSLPALIAHEAELVWQDDEGERAMDAESWLERCRSGTAGPSLLKEIRLPLVEAASGLAVGTAVEAAADVGFGSGSRSEAALDSGGSAERTFSYYHKVGRREAFTPSLATAAMNGTLTEDGVIAQIRIAAGGGSMLAQRLALAEKAVIGAKPGREAAEAMFAAVAAEYAPAPDPFASKEYRIRTVANLLAAEAWKLGRKAPPSEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLZ6</accession>
    <name>A0A398CLZ6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Elongation factor Ts</fullName>
            <shortName evidence="6">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">tsf</name>
        <name evidence="9" type="ORF">D3H35_11540</name>
        <name evidence="8" type="ORF">D3H35_25940</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the EF-Ts family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000044">
        <property type="protein sequence ID" value="RIE00877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00877">
        <property type="protein sequence ID" value="RIE00877"/>
        <property type="gene ID" value="D3H35_25940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03314">
        <property type="protein sequence ID" value="RIE03314"/>
        <property type="gene ID" value="D3H35_11540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="7">
        <location>
            <begin position="54"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="6">
        <location>
            <begin position="81"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE03314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="216" mass="23998" checksum="17B0BE0A97777072" modified="2018-12-05" version="1">MAINAADVKTLRERTGAGMLDCKKALEEANGDLTKAGELLREKGLAAAAKKGDRIATEGTVESYIHAGGRIGVLVEINCETDFVGKTEQFRSFARDIAMHIAAASPKFLSREEVSQAELDKEKEILRNQALNEGKPEKIVDKMVEGRIAKYYEENCLMEQSFVKDQDKTITTLLNEKIATIGEKISIRRFARFELGEGLEKKVDNFVEEVMAQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM59</accession>
    <name>A0A398CM59_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_07580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04436">
        <property type="protein sequence ID" value="RIE04436"/>
        <property type="gene ID" value="D3H35_07580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="106" mass="12247" checksum="438B520E6B6DCE4D" modified="2018-12-05" version="1">MISDEKQYEFAVMMSQLSGDADLYPGKLKSLELMKAYQEQHGLQENEPQTADGWTNMFKIPGLNLTTDARLPPTAWLRWWRLCQHESGFDCPKQEDEGHCGAWIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM93</accession>
    <name>A0A398CM93_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sporulation protein YjcZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yjcZ</name>
        <name evidence="3" type="ORF">D3H35_26580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00761">
        <property type="protein sequence ID" value="RIE00761"/>
        <property type="gene ID" value="D3H35_26580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010070">
        <property type="entry name" value="YjcZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09680">
        <property type="entry name" value="YjcZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="38" mass="3909" checksum="258D703C92B3E09A" modified="2018-12-05" version="1">MGYPVAGAGCGPAYGGMNAAAFVLVLFILLVIILKSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMG0</accession>
    <name>A0A398CMG0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_17075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02419">
        <property type="protein sequence ID" value="RIE02419"/>
        <property type="gene ID" value="D3H35_17075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="178"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="280" mass="32629" checksum="6730A9493C82B545" modified="2018-12-05" version="1">MADQSVLQTLRLNYLFSERYSFPVNWKYFESTIPYAMIRLICKGQATFVIDDRVYRLEKDDVVYIPQGCKLACEAHSDDFTFISIRFTAAFPSSDIDMWSKLVGYDMKIQCKDPQILYYFNCIIREKDSSKQGKFLLLRGYLELILAYLIDSSEQSGTPTIRTPRSVPQENKSNNRVQWIADYMISHYDKSLSIEELSKMANMSSATLRRLFKQHTGKTPSDFLLELRMAVAAKRIVETDERISDIAYKVGIQDPNYFTRVFKKNFGVTPYTYRERVKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMN9</accession>
    <name>A0A398CMN9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1989 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03552">
        <property type="protein sequence ID" value="RIE03552"/>
        <property type="gene ID" value="D3H35_10960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018959">
        <property type="entry name" value="DUF1989"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017791">
        <property type="entry name" value="Urea_carboxylase-assoc_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09347">
        <property type="entry name" value="DUF1989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03424">
        <property type="entry name" value="urea_degr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1989" evidence="1">
        <location>
            <begin position="21"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="218" mass="23963" checksum="2264139D4550C57A" modified="2018-12-05" version="1">MALFNKVESPRQSESAVYDEIVLAGDGWMRELAPGQVLRIVDLEGNQAADTLFYDADNPEDHYSAVRTIAGQRNIYLSTGSVLRAESGKELLTIVADTCGRHDTLGGSCSAQSNTVRYAHEKLHMHNCRDTFMLQLAMHEDGGKYSKRDLAPNINFFMNVPVTPEGGLTFADGVSSPGAYVELKSHGRTMALISNCPQLNNPCNAYNPTPIRVLIWND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMP0</accession>
    <name>A0A398CMP0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellar protein FlgN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02058">
        <property type="protein sequence ID" value="RIE02058"/>
        <property type="gene ID" value="D3H35_14940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007809">
        <property type="entry name" value="FlgN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036679">
        <property type="entry name" value="FlgN-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05130">
        <property type="entry name" value="FlgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140566">
        <property type="entry name" value="SSF140566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="164" mass="18439" checksum="8A4B543020B6852A" modified="2018-12-05" version="1">MIRELIDILDTLQLQHEQLIDLAEAKKEAVMGNQLDKLTEVTSRESRLVKQIGETEQRRVLATASILRKMGLKATARTTLSDLIVYVTTASDKEKLTEAARKLSARVQTLKRLNDQNMALIQQAKDFNDFSLDLLTGGNEPDYIYAKPSVPGNRPKPNLFDSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN26</accession>
    <name>A0A398CN26_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_10360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03692">
        <property type="protein sequence ID" value="RIE03692"/>
        <property type="gene ID" value="D3H35_10360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017251900" evidence="1">
        <location>
            <begin position="32"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="19"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="3">
        <location>
            <begin position="1115"/>
            <end position="1253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1592" mass="171950" checksum="F6ADF92EC7C39D89" modified="2018-12-05" version="1">MNTAKRTFSLFMSTIMLGAALFVLPKEKAVSAEPVNLALNKPISATSFLHSAAEANDGKAQTYFESVYTLPQALTVDLGSGYAINKAILKLPPTFPDRTITLAIQGSADNVTYTDLVASSSYSFQAGAGNSVTVTFPTGAARYVRLTFTGNTSRTSAQLAELELYADNSAADLVVTDISSSPANPVEGQPVTFSAVVKNIGQSATASGVGHTVAFKIDGTTIAVTSPYAEPIAPGGSATLTASGTWSGERYKFDIQAVANANGAIGETNAVNNDDYSEEITVRGAGWQNNFNIKDAIGIYDFPEQLIGYPLDFAGQNVTPAHIRLRQYGQSTPLIYQLSDVVVNGSGYLTSATLHFRTGLNIGGMKRFVVDEDNSYTPSFANEVSLTDNGDGTATISGNQQQLKVPYGNVNANGAELSQVPAPILAVSRQPGAWIGAGSFAAPAGTAVSHWYGRAVEQGPLFIEYQVTYTLADGRVYDALLTIRHNEKYVTVDEKYSGFLSSQNAYLRFSYKNGVDPNGRMAMQNGGYSKTSSGGRSGGYGDGADTNGKLPYELGIYAVNSNSLIRSTSFWNDAGDNAILFAANRLKDWKTESRQTYNAYIKQNLRFYNKPSDKYMEASIEGTERHWALSVIPRSEEVLSGRRLSDMTKPADILIDSEWTNIPTSTGLQPGTAPDVKLWQKLADFSLDGYKDMVFDFPEDASMKLPIPGYGNVTIADPNDYWTDKYCFACFKKYYNLTDKYWDISSDLGPTGNFGRAERYFFSDYAFNRANWGYDERKRTRSLFVFIAYTAEDDNNLPHTSMLGGHPNFNLDVKQVLALAAGAFPGHPHAAAWKSAYLQDFNESLSAFMRKGSGTYGTTGGRWYENLPTYANASLTAMIAAQASLLQYDGTDIFANDNFKTFARWLLNAMSPNERATYRTPVPIGAHASGGDPGGEFDGIYKLLADRVIMGDSVLGGQLLWSATNGAQGTSPALKSAVYQDYGPIMRYDFGGSRETFLYLQQLRGPGYRWFTAANGAIYYATKGKRYSWNGGEESGDLIDINKLPIFTLNGNALGESPTDGVLYDFGDVQYYKALANTTSAPYLSRSVMMVRDEFIGLYDDVGNTTSDGSFLWTNRDTGLKAQYYNNMDFTDLKGVQIDNKRFPGTSWWGAGAPIPAIDPDTYSIAWTGKIFTRFSEPYTFTAAVGTGDTAKVYVNGVLAADTAAGTTTPVPLVANQLYDIRIEYVHNTGPASMQWKWSSPSQSPSNVEGIGYLSNELDQYPNIYEVKAGPGDEFHLVAPDAIPVTNKSYGALVRNNEYVFTSDTTQNVTEGSAVFQGKVGYASPQQLVLIDGTKIGYKDLVLERSGGEFGASVSAAGADSVQGRIVGRSGGTVTVTLPNSFTAAAASVTINGVVVPSSKSGNKMTFNVSIAQNEGVKTYEIAAVQPLFSDTFEDGEADGWTVTAGTWNIANDGATKVYRSAGNGSSTSGSTVWTNYTIKANVKQTGNAAMTSDVIGRYTDGNHFYFLQLDGVGNRLKLYKKVASSVTLLKSVPFTVNRGQWYSMQLGMSGSTLTGSVDGNTLITVSDGELTSGRIGLRSSAETIFDDITVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN72</accession>
    <name>A0A398CN72_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02238">
        <property type="protein sequence ID" value="RIE02238"/>
        <property type="gene ID" value="D3H35_16010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="60" mass="6669" checksum="C8710BFB6360B968" modified="2018-12-05" version="1">MQLIQNFDVQRTPKAYLLVELQIEESQTGLAGLTCSCNTDALRGEASNWDKIQNTIDAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNA2</accession>
    <name>A0A398CNA2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03710">
        <property type="protein sequence ID" value="RIE03710"/>
        <property type="gene ID" value="D3H35_10465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="35"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="130" mass="14391" checksum="8ED6816973F970E1" modified="2018-12-05" version="1">MDLGAKNRSSFQPSAMSVEEVRLALSGSVRCYIYDCNPLRRFEKHRIPGSARLDPGRYTESELPADKNAFVLFYCLEVRCSASLTAARRAMEMGYENAAYMPEGINGWLEAGLQVESGSIAELQVETGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP70</accession>
    <name>A0A398CP70_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BMP family ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_24130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01687">
        <property type="protein sequence ID" value="RIE01687"/>
        <property type="gene ID" value="D3H35_24130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017278228" evidence="2">
        <location>
            <begin position="32"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Bmp" evidence="3">
        <location>
            <begin position="54"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="386" mass="40971" checksum="648D84C4B17479D5" modified="2018-12-05" version="1">MKRTTSSLVFGFLALVLLITGCSQPGNDSKDASGMASPSASAEQSAMGTGGSAVGFIFVGTKDDYGYNQAAYLGSVAVEKAYPDLKVLRAENVPETAEAERVMEQMIKDGAKIIFPTSYGHLEPALNVAKRHPDVVFFHQGGLKTSSNLGTYFGTIWEPVYLAGIAAGKMSKTGKLGYIVSVPIPQVLLNVNAFTLGAQSVNPDAKTSVVFTGSWCDPGQQANATNSLIDSGVDVLSLHQDCMKTVIETAERRGVMTVGYHADASSLAPKGWITGSAWNWSDLFVDMVKTAQEGKFKGSKYDGKYRGTLADNVVQLGSFGANVPADVVQFVEGKKDELLKGTLKPFVGPVKDQSGAVRIKEGETPTVEQLEGSDYFVEGVIGSIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPD3</accession>
    <name>A0A398CPD3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactate utilization protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00794">
        <property type="protein sequence ID" value="RIE00794"/>
        <property type="gene ID" value="D3H35_26760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="64"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="244" mass="26670" checksum="022588F88D21BC46" modified="2018-12-05" version="1">MAIDQEHRDWLAQMEERSKTKQKTFIDGISAKLKRPRVATAPAHPFRGAPEFWKQFDWSTDEKIERFSANFRAAGGHVAKLPDMKAVTGFIAEKAKELGAKYVVRQDQPELAALGLEAELPQGSSLSVWNTDAEEHWKARAAEADFGVVIADYAAAYTGSITVLSAKNKGRSVSLLPTVLFAIIPVERLKTRLGEILPDFDAMGRESLPAGIHFISGPSRSADIENDLTIGVHGPGVVYCLIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPE0</accession>
    <name>A0A398CPE0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_18000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02578">
        <property type="protein sequence ID" value="RIE02578"/>
        <property type="gene ID" value="D3H35_18000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="52"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="240"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="457" mass="49963" checksum="18B9285177975FC3" modified="2018-12-05" version="1">MMSGNLLPVLWAASVIGGLGIGTAATYGLLRSRIRRAQVLFDISMQLNSTLKRQDQLELIMNSAKKVLPVEAASVLIADPDTGELYFELAQGNKGEEVREIRLKSGEGIAGQVAKSGESVIVNDTSSDPRWSSRVADKTGFVTRNLLTVPIRNKDRVEGVLQVINKIGRRGFTRTDRLLLEQVAGPMAVALENSRLYEQVEQSLEALRMTTAIKERLESELQVAGGIQMSFLPRTMPSAQEPYDVCALLKSAKEVGGDFYNFFKIDDEHLFFTLGDVSDKGIPAALFMAVTLTLLKGKMRPGMSPGELLTMVNEELSRDEMTLFATIVCGVFNVATGEVVMSEGGHCTPYVVRAGGAIEPVKLRKSLPLGAFEESVYHDGKLTLGSGDRLLLYTDGITEAENAVQEQYTVERLQQFLEMTPGMSSAEVIDALLMHVFMFADGAPQSDDIAVLSLMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPJ0</accession>
    <name>A0A398CPJ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_26130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000047">
        <property type="protein sequence ID" value="RIE00854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00854">
        <property type="protein sequence ID" value="RIE00854"/>
        <property type="gene ID" value="D3H35_26130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="84" mass="9488" checksum="4BD3FE589BE39D90" modified="2018-12-05" version="1">MFAYGGKDETAIGNVLHWTFGDYAVKDPAFKEAYLSNTVDWSKPEYRSMLKEGLERFKQLNAYVRTGSFTNDGSSHSKRSPKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPS1</accession>
    <name>A0A398CPS1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagellar biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03289">
        <property type="protein sequence ID" value="RIE03289"/>
        <property type="gene ID" value="D3H35_11405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013367">
        <property type="entry name" value="Flagellar_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12611">
        <property type="entry name" value="Flagellar_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02530">
        <property type="entry name" value="flg_new"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="125" mass="13476" checksum="7CDAD13E9A9DD068" modified="2018-12-05" version="1">MFIGQLTTGRTGPLQSPNRKSVGNVELAKAGASFREVLSNQELKFSHHAEMRLQQRGIKLNSDQLGRIESAIDQAAAKGAKDSLVLFKGIAMIVNVPNRTVVTAMDGASMNEHVFTQIDSAVVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPZ8</accession>
    <name>A0A398CPZ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_21635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01044">
        <property type="protein sequence ID" value="RIE01044"/>
        <property type="gene ID" value="D3H35_21635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017347364" evidence="1">
        <location>
            <begin position="38"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="144" mass="15744" checksum="F3291E9D99EEF672" modified="2018-12-05" version="1">MFDQQRRRKARTAAVLILTLTIGLLTGCGVNKNTNTATEDGVKTQSYGDDGYLGMTNSHTKIPGRHMALNYKNDANMMAQSIRNLPGVAGTNVTFSGSDAYVTVKLAPSLADRDVPALERQAASVLRFNFPRYNIHVKSLRQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQI5</accession>
    <name>A0A398CQI5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Prepilin leader peptidase/N-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
            <ecNumber evidence="10">3.4.23.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D3H35_23545</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine.</text>
            <dbReference type="EC" id="3.4.23.43"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase A24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EC" id="3.4.23.43" evidence="10"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01681">
        <property type="protein sequence ID" value="RIE01681"/>
        <property type="gene ID" value="D3H35_23545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010627">
        <property type="entry name" value="Pept_A24A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014032">
        <property type="entry name" value="Peptidase_A24A_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06750">
        <property type="entry name" value="DiS_P_DiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00864">
        <property type="entry name" value="PREPILNPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="169"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DiS_P_DiS" evidence="13">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="12">
        <location>
            <begin position="94"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE01681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="245" mass="26766" checksum="A521CB9B12BDA040" modified="2018-12-05" version="1">MGLLIGSFLNVVAIRVPEGRSIVFPASHCMKCGNTLRKFDLVPVLGYIWLRGKCRFCKTSVSPVYPLGELVTGTLFAVYAWQMGWQLELIPALLFVSILLVIVQTDLRLMIIPDRVVLFGLLAIVPIRLFVSHPLPLWSYAVAGLGVGILLFLLAVVSKGGIGGGDIKLFALLGLFLGLQNTFLALFIASLLGVLVGFATRLLRKDSKKKFIPFGPFIAAGALFSYLWGEKAFTWYWSLLTSGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQJ5</accession>
    <name>A0A398CQJ5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Thymidine diphospho-4-keto-rhamnose 3,5-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rfbC</name>
        <name evidence="4" type="ORF">D3H35_15105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:16969"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="5.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02087">
        <property type="protein sequence ID" value="RIE02087"/>
        <property type="gene ID" value="D3H35_15105"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01221">
        <property type="entry name" value="rmlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="187" mass="21480" checksum="D10B1F07EB878A19" modified="2018-12-05" version="1">MKLISTRFADAYIIEMDVHGDHRGFFTESYNERSFREKGLIYDFVQDNHSLSVEAGVIRGLHYQLNPKAQTKLVRVIAGAIYDVIVDIRRHSPTFGLWQGFELNETNKRQLLVPRGFAHGFCTLVPNTQVTYKVDEYYSPEHDRGIAWNDPSLGIDWPVSNPVLSGKDQSHPHLEEAEMNFDEEVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQP7</accession>
    <name>A0A398CQP7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_15450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02147">
        <property type="protein sequence ID" value="RIE02147"/>
        <property type="gene ID" value="D3H35_15450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017441643" evidence="2">
        <location>
            <begin position="33"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="219" mass="22938" checksum="E5F26A8CF8535E17" modified="2018-12-05" version="1">MKKTTTLAALGVGTLLLLSACQATSMRQKSVAQEHAVENKQNARAIHQMERKTDERGPTSHGMGTSVYSIIGSSGLHSHGLSSHLESRLGSAGITGVKAFTLDDMVILATAKRKQEASAQSDELQQKLLSPSGSLSGRSLGGSPGRIGKLNADGAGADNIASAEKWIHENLGSGVKVYSLVDPEAVAAIERIRSHADAAPAQQADDIQRLLQLAKAPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQR9</accession>
    <name>A0A398CQR9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_05140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04852">
        <property type="protein sequence ID" value="RIE04852"/>
        <property type="gene ID" value="D3H35_05140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="308" mass="34192" checksum="D3027B23F3EC2C99" modified="2018-12-05" version="1">MSAQNVKKEIGFDWRKLFINPVLNKEITLRMRTLRSMWALFFYLLAIGIGALGFLYITQMDGGRSGFNPDASRTMFMFISMAQLGLIAFMAPGLTAGIVSGERERQTLNLLLTTQQTSANIILSKLAAALAFMVLIVVATMPVYSIVFLYGGISPSQLTMVFLFYLFVMIVFGSLGILFSTLLKRTMISVIVTYGVTLFSFGGTAFIYLILNSIMDNTYRGSANIPDYGWIGYIMGLNPIAALYSVFDSEISRSVFRAGYSSANYQKDAPIELWQEFLIVYTIIAVGAVLLSIRKIRPALKKRSTSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQX2</accession>
    <name>A0A398CQX2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_03540</name>
        <name evidence="2" type="ORF">D3H35_13840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000022">
        <property type="protein sequence ID" value="RIE04912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01863">
        <property type="protein sequence ID" value="RIE01863"/>
        <property type="gene ID" value="D3H35_13840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04912">
        <property type="protein sequence ID" value="RIE04912"/>
        <property type="gene ID" value="D3H35_03540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="343" mass="39497" checksum="09968718ACA7DB21" modified="2018-12-05" version="1">MRIKEVANMLNLSPRAIRFYEEQGLLAPSKDKTNRYRTFTEQELERLRTIISLREAGMPLEHIKQWLDGSSDETEARDELLRFLEMRRSAIVADWIEMKQVIETTDRMLLLLKDRDKEIPYADLFQLADDSRQLREQRKNWLDRWNYDLLADHHDERVRASSGTFADYEEALELVAEWLSPIPGETGLDLGVGTGNLASKLLDRGARMCGVDQSAKMLEQCAAKLPELETKLGNMLAVPYTNGQFDFIASSFAFRHLSAEQQPLALEEMRRVLKPHGRISIADLFSLSDADSDLDDSDPMSGYPKLPTVIRWLEAHGYMTRARRINDMLHLVCAVPIRPQNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR54</accession>
    <name>A0A398CR54_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_02600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05045">
        <property type="protein sequence ID" value="RIE05045"/>
        <property type="gene ID" value="D3H35_02600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="80"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="284" mass="30328" checksum="86E8F5900B73114B" modified="2018-12-05" version="1">MAHEAAARLDGRSESATIRKSASGSRLLRSLFPPLAAFVVFAAIWQFGLVLLGTPAYLLPKPTDIAAAAAENADNLLSSVWTTAYESLLGFLLSIVIGVAFAILLATSRLIEKSIYPYAIILQTIPIVAIAPIIVIWFGAGLNAVVIIAFLIGFFPMLSNTLIGLNSTDQNLRNLFYLYDAGKWQTMWRLRIPAALPYMVGGLKISASLSVVGSIVGEYVAGIGGGNGGLGFAITSAAIRLQTPYLFACGLSASALGIVFFLIVNQISKWLLSSWHESAMRTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRB3</accession>
    <name>A0A398CRB3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_24155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01454">
        <property type="protein sequence ID" value="RIE01454"/>
        <property type="gene ID" value="D3H35_24155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032836">
        <property type="entry name" value="DsrE2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13686">
        <property type="entry name" value="DrsE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01148">
        <property type="entry name" value="UPF0033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="466"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="555"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="560"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="823" mass="89468" checksum="8AEC0FCDF3D33640" modified="2018-12-05" version="1">MTSRTIVIVGGVAGGASAAARLRRLNENDRIIMYERGEHISFANCGLPYYIGETITSREKLLIQSPAAMKNRFEIDVRTRTEVIRIDRERKQVHVRSAETGMEAAQPYDLLLLSPGARPIMPDIEGLREANNVFTLRNIPDTDRIKRYVDERKPGHATIVGGGFIGIEMAESLRERGMDVALLERNAQVLGPLDFEMAKAVERHVAQKGVKVVLNTAIAAVERAGTRIRLDSGKIMDTDMIIMAIGVEPENILAKEAGLELGVRGAIKVNEHLQTSDPAIYAVGDAIEVKDRINGFDTVVPLAWGANRQGRLAADHMNGREAVYRGAYGTAIVKVFDLTAAVTGSNEKTLRKLGIPFETIHIHPNSHAGYYPGAASIALKLLFDPSTGAILGAQAVGSEGVDKRLDVIATAIRAGLRAQDLADLELSYAPPYSSAKDPVNMAGYVASNVMEGLVRTMQWHEVDGFVAEGGLLIDVRDAVERDFGYIPGSVNIPVNDLRERLGELPKDKELVVSCQVGLRGYIAARMLAQHGFRVRNVDGGYKTYSAAMWKDEESASFPSNDSKRESAPVQVQPETQRPTKSVLVDACGMQCPGPIMKVYEAMAELGEGDLLEVKATDFGFSSDIKKWAEKSGHSLESLDTSSGVVHATIRKAKAAERRMTTGRQSETRDGTTMVVFSGDLDKAIASFIIASGAAAMGKSVTMFFTFWGLNVLRKPDAPSVRKSGLERMLGFMMPNSSKSLPMSKMNMAGMGPRMIRHVMKKKNVDSLEQLMDGAIRAGVKLVACTMSMDIMGIKREELMDGIEYGGVATFLGDAEDAGVNLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRC7</accession>
    <name>A0A398CRC7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_01040</name>
        <name evidence="2" type="ORF">D3H35_03035</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000008">
        <property type="protein sequence ID" value="RIE05331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05115">
        <property type="protein sequence ID" value="RIE05115"/>
        <property type="gene ID" value="D3H35_03035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05331">
        <property type="protein sequence ID" value="RIE05331"/>
        <property type="gene ID" value="D3H35_01040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="211" mass="24537" checksum="36812C651C65ABE7" modified="2018-12-05" version="1">MELEIYKYLHDQSDFFDVAEKMSKASSLMPYELLKESMQCKNESDIEKRKGLIEELYTKIKDEILRLKRNQYDSITSKSSDGVTSIENFMKSKLAPFVYPLMPTFCNLVLLLLTIYFIFLMSESTITQQILYISVVMAVVIYGTLMISMVSLVIIKKRFNNSWLNWMLFFLFVLSPLSLFEGPWYRGIIAIVLIIAYGFYAAKKSIKKSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRV4</accession>
    <name>A0A398CRV4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_22405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01664">
        <property type="protein sequence ID" value="RIE01664"/>
        <property type="gene ID" value="D3H35_22405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="188"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="422" mass="47587" checksum="B940500A193C4576" modified="2018-12-05" version="1">MGLGQVYNRQYMKGLLMLLLYFTGLYFIITVLPKALWGLVTLGDKADRLEKVGRVYVNVRGDHSIFLMVEGIIALLAALVLVYIYALNIRDAYRVGKLRDEGGTANGFGTTVKRITEERFPLLVLSIPLLLVVFFTAMPILFMVLLAFTNFSFPNYLPPAKLVDWTGFKSFVDMFNVKAWSGTFIGVTVWTLIWMVSATVTVFFGGFLVALLVQMKGIRFKGFWRTLFIIPYAIPQFISLLIMKNMFNGQFGPINQYLSYFGLGKLPWLTDPFWAKVTVIIVNIWIGFPITMLMIIGILSTISKDLYEAAEMDGASGYRQFRAITLPSIMYAFGPILVMSFAGNINNFNLIFLLTGGAPANADYKFAGSTDILITWLYNLTLTQGKYNYASVIGLFIFIVIASLSIWNIRRTKAFKEEGDFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRX6</accession>
    <name>A0A398CRX6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RHS repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02547">
        <property type="protein sequence ID" value="RIE02547"/>
        <property type="gene ID" value="D3H35_17815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="500" mass="54738" checksum="A0FE2896574BDCD3" modified="2018-12-05" version="1">MAKGMRPGTGATVDERIKSGYGTVTAYNAANLPITVLDPAAAERGLKFSTKYSYDGAGRKVAVQDASGAIRGTRYDDAGRVLAETIQAASSTPVKTLKTNTYDAAGRLISQSDGNGNQTTYAYNAFGQVRESVEPGDESIAALTMRYQYDVRGQLTRTTDSTGIVRLTSYDPQGRAISQTEQKEDGSEAITTSARYDRNGNKRFEMDGNGNTTEFVYDLLNRLVETKVTVTDVSGAKKKQSTTYGYDRNGNKLWAQNWLGNRTTYAYDDRNRLISTTDATNVVVEKLHYNKNDAQIATYDALNNVTTYAYDRNNRQLSVTNPENKSTSQSYDNRGLVASKTDGNGNTTRYTYDELGRLSSVVNALGEKTTYTYDLNGNRVTERNAAGQVATYEYNAANKLLRRVDDGGRTGKAGGYAYNPAKTETYTYTPSGQLLTKIDRNGNTTTYTYDAHDRLLSQTVTGSSLTLPAKDNRVVYTYDNSGNQLTMTDGTASPAVRTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRY2</accession>
    <name>A0A398CRY2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylneuraminate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03979">
        <property type="protein sequence ID" value="RIE03979"/>
        <property type="gene ID" value="D3H35_08450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="303" mass="32755" checksum="CBDB3302C0ACAD21" modified="2018-12-05" version="1">MSIAKFQGIIPAFYACYDDKGDISEARTYELCDYLHGKGVQGVYVGGSSGECIYQSLEERKAVLGHVARRLQGKMTLIAHVGAPSTRDSVELAKHAADLGYDALSAIPPIYFKLPDSAVYRYWSEIIDSTPLPFIIYNIPQTTGYTLTTSLFRKLLENPKVIGVKNSSMPVLDIERFKNAGGDEVIVFNGPDEQFVAGRIMGAGAGIGGTYSAMPELFLQADKLVRNGRFAEAGAIQSDINDIIIALCSLDGSMYAGIKEVLRRRGVNVGGVRSPLEDISGEDAARIDAIVRQIDEAAVKHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRZ0</accession>
    <name>A0A398CRZ0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01704">
        <property type="protein sequence ID" value="RIE01704"/>
        <property type="gene ID" value="D3H35_12895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="169" mass="19227" checksum="BFFEDF21DD5C36B0" modified="2018-12-05" version="1">MKRHWKIGDLAKLTGLTVRTLRYYDQIGLFSPSGQTESGHRLYSELDLSRLHQILSLKELGLSLEEVKAALTGGQISPLEIVNLQIGRIKEQIKLQQKLLEQLGHVSKLLQGKAQLTIEDFTSLLQAMKMRFEKPVVERQTSWERHLDLLGDFLAVESGTPKPNKEENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSH9</accession>
    <name>A0A398CSH9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_14075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01904">
        <property type="protein sequence ID" value="RIE01904"/>
        <property type="gene ID" value="D3H35_14075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="525"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="609"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="751"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1012" mass="111684" checksum="4CA8E26F2FF63781" modified="2018-12-05" version="1">MGKPFRIGVVAQRLDGEYYGKVLASILKAVHSRNGQLIAVEIADDDLETASTERPVSFQLADAWILIMPTAGDALLQRFGQSGKPVVCVGFPPPGDEYAVLVDGRGGMKKAVLHLLDHGHRRIAFVGQREQYDLYERYIGYVEALAERGIPVDPELVRSASDNLFEGGMKAVEGLLLEGIDFTAIAAGTDLNAIGAIGALRKGGLSVPGDVSVTGFDDISQSAIHIPPLTTLRQSFDQLGERAVGKAFELLEYGATPFRVDYVPVAFVPRSSCGCVQNFEVNREELVRTRQSLSDLRTTIHQVTNSYFRMTNGLIQGIKSESIHIASLYWDSSHWGCLALWETDAGGGRSLVVRQTFSRRGEPVPREGERCALEQFPPAEWLPPSAGPGKDELVIVHPIRSELQEWGYLVMVGPFSPANHYAASDMSRQSCLILAVTLEREKLWGRIRSMAEKLEVVSRTTNDGIWDWDLGTNRIEWNLGMDKVLSRSSAKLTDKPISFLRLIHPSDSVKVREALAPPYPEGRPLQLEFRIRGQEGNDIWLYMAGDIIRNDEGRAVRMIGSVTDITEKKAAEAEIMRLAYHDALTGLPNRLLFRERLKEAIVQAKKAGGKLFVLMIDLDRFKIINDTLGHQAGDRLLCKVAATLQATLGAKDTISRLGGDEFIVLLPRAKALEDVRRITELMLKQLEQPFMLAGQELYVSASIGTSMYPDQAGDADTLVKYADMAMYQAKANGGSGMRVYTPDLGTQNAERFEMEKGLHKALEREQFRLVFQPQIALGTGAVYGAEALVRWESEDRVIPPCEFIPLAEDTGLVVPIGLWVLRQACAEARRWADAGMAELVVSVNLSAQQLETNDFPATVRKVLEETGVAPNRLCLEITEYSAVQNLDRCIKLLKELTDIGVIIAIDDFGTGQSPLVLLKRFPVQTIKIDPSFVRDMSEDSGGEAIVRAVIAMSHSLGLTVTAEGVETEEQLEILHRMECDRIQGYYTGRPMASDAFVAYYRGVASGVSSWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSQ0</accession>
    <name>A0A398CSQ0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="10">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ileS</name>
        <name evidence="14" type="ORF">D3H35_06605</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="10"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04279">
        <property type="protein sequence ID" value="RIE04279"/>
        <property type="gene ID" value="D3H35_06605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="12">
        <location>
            <begin position="17"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="13">
        <location>
            <begin position="674"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="10">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="10">
        <location>
            <begin position="588"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="591"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE04279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1030" mass="115601" checksum="6FB4198C5D0254BA" modified="2018-12-05" version="1">MNRVDVKERARARELRVLQQWNEQSTFRKSIENREGKPNFVFYEGPPTANGKPHIGHVLGRVIKDFVSRYKTMAGYRVIRKAGWDTHGLPVELGVEKQLGISGKQEIEKYGVEPFVKKCKESVFEYEKQWRELTEAIAYWTDLDDPYITLKDEYIESVWHVLATIHDKGLLYRGHRVSPYCPDCQTTLSSHEVAQGYEDVKDLTATAKFKLTGSGEFALAWTTTPWTLPANVALAVHPDIEYVRVKQDGEIYILAGALAPKVLKGEYEVVGTVKGSELVGLTYEPIFPYVRVEGAYRIIDADYVSDSSGTGIVHIAPAHGEDDYRVAREHGIGMLMVVNNAGRYIDAVTDLAGRFVKDCDVDIVKMLSERGLLYHKERYEHSYPFCWRCKTPLLYYATESWFIQTTAVKEQLIANNQTVQWYPEHIRDGRFGKFLEDLVDWNISRNRYWGTPLNVWACDDCGKHKAVHSRAEMVELAVGDVPADIELHKPYVDEVKLRCSCGGTMNRTPEVIDVWFDSGSMPFAQYHHPFGNEEKFNEQYPADFICEGIDQTRGWFFSLLAVSTLYNGQAPYKSVISTGHVLDENGQKMSKSKGNVIDPWEIINEFGTDAFRWALLADSAPWNSKRFSKGIVAEAKSKVVDTLVNTHAFYALYADIDGFVPSEHAVRKSGNKLDRWILSRLNSLIASVVKDLNVNDFLNPAKAVETFVDELSNWYVRRSRDRFWGSGLSEDKVAAYQTLREVLLTLSKLIAPYVPFVAEDIYGNLGGGGSVHLADYPQADDSMIDAELEREMAAARGIVELARNVRNESGIKTRQPLSELLMSLSEPFDVVGYEDIIKDEINVKTITLVSDDAGFVNFNLKLNLKIGGKKYGKNVGPIQAALKGLTAEQSHDVVKSGLLKFVSPDGEELDIPVKELLIEKEAKSGFASASGGGLTVALNTEITPELEQEGLVREVIRAVQDTRKKMDLPIELRIHLLLEVDTETEAAIKAFRHVLNENVLVNEVSFGSSADMETVQAGEKTIRLSISTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSR5</accession>
    <name>A0A398CSR5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translation initiation factor IF-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">infC</name>
        <name evidence="7" type="ORF">D3H35_01970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05200">
        <property type="protein sequence ID" value="RIE05200"/>
        <property type="gene ID" value="D3H35_01970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="6">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="5">
        <location>
            <begin position="76"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="54"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="157" mass="17048" checksum="8B92411B6F587F7C" modified="2018-12-05" version="1">MLINEKIKASEVHLTGLNGEDLGIVPTSEALAMAKSLKVDLIALSLMSSPPPCKLMRSGAAKEEAQKEKKKEREPKLKEVRLTPQTEEHDLETKRQQAERILKSGGSVFLVIKAQGKDGTKAKELLQRLIKDLSSSGKPKTGIQLSGKQAAVQLDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT53</accession>
    <name>A0A398CT53_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ger(X)C family spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_00680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKC lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05340">
        <property type="protein sequence ID" value="RIE05340"/>
        <property type="gene ID" value="D3H35_00680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008844">
        <property type="entry name" value="Spore_GerAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038501">
        <property type="entry name" value="Spore_GerAC_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35789">
        <property type="entry name" value="PTHR35789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05504">
        <property type="entry name" value="Spore_GerAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02887">
        <property type="entry name" value="spore_ger_x_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017353111" evidence="4">
        <location>
            <begin position="25"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE05340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="376" mass="42859" checksum="DBEB5DC84FF48330" modified="2018-12-05" version="1">MRRLRLIVGASLLLLAILPGCWNSKDVQNLAYVTAIGIDYSEDQYHMYMQVLNFTNVAKTENAELGKSIPIWVGKSTGKTLAEALGKIKETSQKSVYWGHVKVIVLTEDVLKRPINEVIEAINRYREVRYNINVFGTKEKLTDIFVQKSIFNLSPLDTLMYTPEQIFTPITGNKFIAQISEPGHSGAMPAIRIDRASWNEEKEKKPMLRLAGVYFFENRKMNAHLPEPEMVGMRWMARKISNVIINVPSEGEVAASVALISSRFRVLPTVRNGTVKFDIRAKLTGYIIELNKNESVALLGKEAAEVIKNDLLNTYRYGLKAKCDPYFLRHALYRDYPRIYRKLIAEEPFFLKEDSLGKVEVKVELTNTGKYKGRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTR8</accession>
    <name>A0A398CTR8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydrogenase expression/formation protein HypE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hypE</name>
        <name evidence="5" type="ORF">D3H35_12825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000038">
        <property type="protein sequence ID" value="RIE03257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03257">
        <property type="protein sequence ID" value="RIE03257"/>
        <property type="gene ID" value="D3H35_12825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02197">
        <property type="entry name" value="HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005644">
        <property type="entry name" value="Hdrgns_mtr_HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02124">
        <property type="entry name" value="hypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="3">
        <location>
            <begin position="41"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="4">
        <location>
            <begin position="165"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="340" mass="36112" checksum="EEF3D3F292F1DEB9" modified="2018-12-05" version="1">MSKEKLKHIVLDHGTGGKLSGELIGAITERLGEVHVGKLEDSAILPIGAGRIAVTTDSFVIDPIFFGNGNIGHVAVCGTVNDLAVSGATPKYLTLAFVLETGFPVEDLERILDAIREAAKEAGVLIVAGDTKVVRKGEVDKIFINTAGVGEFAPDARSYSVSQIRPGDHVIVTGELGNHSIHILSIREGLGFETKIKSDCAPLNKLIADLNGSFSEHIHTIRDITRGGLGTVLNEIAAAVGRGISVEEQKLPILHETAMAANMLGVNPLYLANEGNLILFVAPEHSAAIVERIRQNPYGRSAAVVGVVDETTDTRVHLTSKNGETKTIDLLYGAELPRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTV0</accession>
    <name>A0A398CTV0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flagellar hook-length control protein FliK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_11395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Controls the length of the flagellar hook.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03287">
        <property type="protein sequence ID" value="RIE03287"/>
        <property type="gene ID" value="D3H35_11395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001635">
        <property type="entry name" value="Flag_hook_Flik"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021136">
        <property type="entry name" value="Flagellar_hook_control-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038610">
        <property type="entry name" value="FliK-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02120">
        <property type="entry name" value="Flg_hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01007">
        <property type="entry name" value="FLGHOOKFLIK"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_hook" evidence="5">
        <location>
            <begin position="333"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="406"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="406"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="467" mass="48271" checksum="5222B95D530940BE" modified="2018-12-05" version="1">MMNTIGVVANSSSAGSSAGSGKAGSTSGAFAGMLVQVLDGSGAAKSAPAKTALPVGLIGIVGQLPAMPADDAALQETLALLDELVNQLNDQESKEEPDSDVADQLTALLAALQLLLGEPAADMTDTNASEDAESAEPSIETINIGQEVRKVVQTLGETIGKLSAGLAQGQQSPAAVSVLALQLQSVLESWEGMLTQDKAGGKAVANADSAQASVPSASVGEASAKKSETPDETAAAVATEVKKTAQPLREAAWRPVNAVHTETPDGESIEPQQLASSIEAEPKSTSTAPVWSLQMNDALKGTAPSAPQLPAQIPVQQFADQMEKFLVKQFVLTQGNGISEAKITLHPEHLGQVDIKIVLQNGQLTAQFVTEHLTARDLLENQLSQLRTALQGQGLQVDRMEVVQQTSSSAGASLQQDQRQSGSGGQGDGNNSGNKDGGSGEDLFEAELERTTFLREFGYGSSLNVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUD4</accession>
    <name>A0A398CUD4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta</fullName>
            <shortName evidence="13">ACCase subunit beta</shortName>
            <shortName evidence="13">Acetyl-CoA carboxylase carboxyltransferase subunit beta</shortName>
            <ecNumber evidence="13">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">accD</name>
        <name evidence="15" type="ORF">D3H35_19870</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="13"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02881">
        <property type="protein sequence ID" value="RIE02881"/>
        <property type="gene ID" value="D3H35_19870"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01395">
        <property type="entry name" value="AcetylCoA_CT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041010">
        <property type="entry name" value="Znf-ACC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17848">
        <property type="entry name" value="zf-ACC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00515">
        <property type="entry name" value="accD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="15" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="14">
        <location>
            <begin position="33"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE02881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="294" mass="32496" checksum="C3A37CC278647B8B" modified="2018-12-05" version="1">MFKDLFQKKKYAVIPSERVSNPDRPKREIPEGLMNRCPKCGTIQFSKELEKNLKICSTCGHHFRLNAWERIAMTLDEGRLFELDADLISEDPLQFPGYAKKLEQQKESSGLKDAIVTGTGTIGGFELVVGVMSFDFFSGSMGSVVGEKVTRAIEHAMEKKLPLLLFSTSGGARMQESILSLMQMAKTSAALAKFQEDGGLFISVFTDPTLGGVSASFASLGDYNLAEPGSIVGFAGRIVIEQTIRQKLPENFQTAEFNLKHGQLDKVVHRKEMKATLTKLLDMHAWKGEPANVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUF7</accession>
    <name>A0A398CUF7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF402 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_04595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04899">
        <property type="protein sequence ID" value="RIE04899"/>
        <property type="gene ID" value="D3H35_04595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007295">
        <property type="entry name" value="DUF402"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035930">
        <property type="entry name" value="FomD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04167">
        <property type="entry name" value="DUF402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159234">
        <property type="entry name" value="SSF159234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF402" evidence="1">
        <location>
            <begin position="61"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="186" mass="22161" checksum="408B29B53E213D7E" modified="2018-12-05" version="1">MKRKFSDRANWRRILKKSYACFPMDDAQFRGFVTLYRIHDLRDPLWKDYNGRRMCLADRGYLWMQHFPKGEHFIVTTMFDNNGNVVQWYIDICKTQGLTDQQVPWFDDLFLDIVVLPTGETLLLDEDELEEALDEGQITARDSAMAQRTAARLLDLIKQKKFPYFDMSLQHRKHYLDKLGWEKGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUQ9</accession>
    <name>A0A398CUQ9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02734">
        <property type="protein sequence ID" value="RIE02734"/>
        <property type="gene ID" value="D3H35_18985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="151" mass="17712" checksum="32AD6C5AE322D3A6" modified="2018-12-05" version="1">MDDQQRVLDIFKSFREVNQAFFQGMQKAAQHHGVTPLQFMVLRILNNCPEIRLSELAEQLHLGNSTTSGIIDRMVKADLVSRERSDTDRRNVILKLTDKGNDMWKQTHQTRLERLAPLLELAEEDQAHLQRIHNQIVQILHRVREEETNHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUS3</accession>
    <name>A0A398CUS3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000035">
        <property type="protein sequence ID" value="RIE03617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03617">
        <property type="protein sequence ID" value="RIE03617"/>
        <property type="gene ID" value="D3H35_10785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="111" mass="12331" checksum="236AF80406B7F2EA" modified="2018-12-05" version="1">MTSINRSAEKVPFTARMTDLAGETFEYRHSFDPAKGDTAFRCEIRSKPASHRASRIQLTADGNETAFELRDAVFPVERLASGEELVFTIVPQTAAAEQARSTCYRSREGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUW6</accession>
    <name>A0A398CUW6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sensor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_19410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02804">
        <property type="protein sequence ID" value="RIE02804"/>
        <property type="gene ID" value="D3H35_19410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Sensor" evidence="2">
        <location>
            <begin position="14"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="232" mass="25462" checksum="1F7EE1DA6746DB9A" modified="2018-12-05" version="1">MKKRKARAAWTMMVTSLPRGIAVFVIAIVGVCVGLPLAPFIIGLPILAATLKACERLMSGERKLAATWDRGEAHDPEHWEAQAAQSNDSERAATGWRSWIATLGRVQNYRGLLFGVAQLPATISAFTLAIVIPATFAGIALTPLAYLVSDRVFSFELFGDDWLLNRVFTNLTPENYSYIIGGIGLVLLLLTPYLIRRLGRMYAAWIRWIAGEEKAIDVSEPHGSAGLAESYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVJ5</accession>
    <name>A0A398CVJ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03034">
        <property type="protein sequence ID" value="RIE03034"/>
        <property type="gene ID" value="D3H35_20810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="83" mass="9711" checksum="11B22436A68CD92D" modified="2018-12-05" version="1">MRYTLTLACTIIGIALCLFNYSGYDPHNIFFLMFSVPTWFVELFGDIHRVNLWTLYVLTVISYAVIGYLCDRGIAKIRTWKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVM8</accession>
    <name>A0A398CVM8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03271">
        <property type="protein sequence ID" value="RIE03271"/>
        <property type="gene ID" value="D3H35_11305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="173" mass="18518" checksum="48AA10CD0FD5C747" modified="2018-12-05" version="1">MAIQFLDMMVSQQLDSPSGTTVLTTVPLLIGDLGVSTSLVVGTPNQDKVRVGLSGTVGILHNAKDKHDKDKHKDKKKDKHDHDSHASVLFTIERGGNGTFGSGTVIYQEEYRPVKKHTSLIPVSITTTDFPPSAAAAQSLIRYTLYVALDVPSEAFILTGPIAIYGVAVAGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVN9</accession>
    <name>A0A398CVN9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05379">
        <property type="protein sequence ID" value="RIE05379"/>
        <property type="gene ID" value="D3H35_00920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="115"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="249" mass="28682" checksum="034BCB1C0E839C64" modified="2018-12-05" version="1">MNNKFIEELSLNNWQPLSTIHYDGWILRFADGYTKRANSINPIHYSTCDLNYKIAECERIYSANCLPAIYKITPFVHPIDLDKILESKDYSLIDTTSVQTLDLANLNEPTLNSTKIVETVNAEWIADFCRINNVNDQNNGVLERMLSNIKTKTGFISLYYEDQVIGCGLGVIERGYIGLYDIVTDLHFRNRGFGEQMILSLLKWGKANGAKYSYLAVVSNNRPALRLYSKIGYSEIYTYWYRVKDSKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVQ6</accession>
    <name>A0A398CVQ6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SgcQ protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_21250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BtpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03104">
        <property type="protein sequence ID" value="RIE03104"/>
        <property type="gene ID" value="D3H35_21250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005137">
        <property type="entry name" value="BtpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21381">
        <property type="entry name" value="PTHR21381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03437">
        <property type="entry name" value="BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005956">
        <property type="entry name" value="BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00259">
        <property type="entry name" value="thylakoid_BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="273" mass="29824" checksum="3B8845D1C48C4FC3" modified="2018-12-05" version="1">MNWLQEVYQTNKPIIAMCHLNALPGDPYFEKSGGMEKVIEDARKDMLALQAGGVDAIMFSNEFSLPYLTKVKTETVASMARIIGQLMSELKVPFGVNVLWDPTASLDLAVATGAKFVREIFTGVYASDFGLWDTNCGEVIRHQRAIGAENVRLLFNIVPEAAKYVSDRELTQIAKTTVFNCKPDALCVSGITAGQETSLSLLRLVKEVVPDTVVFANTGLKAENVKSQLAVADGGVVGTAFKYDGKFENHVDPDRVIAFMEQVHSARSNLTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVT6</accession>
    <name>A0A398CVT6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin prenyltransferase UbiX</fullName>
            <ecNumber evidence="5">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ubiX</name>
        <name evidence="7" type="ORF">D3H35_03925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04648">
        <property type="protein sequence ID" value="RIE04648"/>
        <property type="gene ID" value="D3H35_03925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="PTHR43374"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0288">FMN</keyword>
    <keyword evidence="1 5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="6">
        <location>
            <begin position="9"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="106"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="207" mass="22674" checksum="D1993569D2090D38" modified="2018-12-05" version="1">MVTGAPDRRWVVGITGASGAAYGIKLCRELLAGGYVIHLVVTDAGWRVFKEELGWDASRRMETLRHAFGDEPFEEGRLIYHPLNDIGASIASGSFRCEGMVVVPCSMGTLSSIAHGASTNLLTRAADVMLKEGRPLLLVPRETPLHAIHLENMLALARLGVRIIPAMPAFYYGPQTLDDAVAFMVGKVMDSMSVPHNLYRRWGESHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWJ1</accession>
    <name>A0A398CWJ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine triad nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_06140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04197">
        <property type="protein sequence ID" value="RIE04197"/>
        <property type="gene ID" value="D3H35_06140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="4"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="97"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="114" mass="12261" checksum="7B8D6E3AFD2AC482" modified="2018-12-05" version="1">MDCIFCKIVEGTIPSRKVYEDDDIVAFHDIQPQAPVHLLVIPRKHFASLDAAAPEDAVLLGKMMLVAKQIAHEAGLTADGYRVATNIGANAGQIVFHIHLHVIGGEKLAGINAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWT5</accession>
    <name>A0A398CWT5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase DegT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_06705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04297">
        <property type="protein sequence ID" value="RIE04297"/>
        <property type="gene ID" value="D3H35_06705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="381" mass="42391" checksum="78505A9F9C424443" modified="2018-12-05" version="1">MSEQGYEKEFVNEAFDTNWIAPLGLNVDGFEKELAEYVGIDHAAALTSGTAAIHLALKAVGVREGDIVFCSSLTFAGSVNPVLYEKAIPVFIDSDYETWNMSPVALAKAYEKYPSPKAVIVVNLYGQAADYDAIREVTDKYGTPIIEDAAESLGATYKGIQTGMLGDIGIFSFNGNKIITTSGGGMLVCKNEDVTQKAKFWATQARDNAPWYQHSELGYNYRISNIAAGIGRGQLKVLNERIEYKTLIYEFYKKSFSDIAEIQMMPVCEYGSPNYWLSSLVLDNSCFIKPNDIIRALATKNIESRPIWKPMHMQPLFSSSAFFSSRNEESSVSEDLFNRGICLPSDTKMTLEDMQVVVGIIRKLFGKTELHRESLDVQKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX78</accession>
    <name>A0A398CX78_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000035">
        <property type="protein sequence ID" value="RIE03604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03604">
        <property type="protein sequence ID" value="RIE03604"/>
        <property type="gene ID" value="D3H35_10720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="145" mass="17170" checksum="66118EB08E1B2695" modified="2018-12-05" version="1">MLSKETVTEASWKMFVMDSGKTRFRYKIIYRAVDFRDVELPWMETDEERLTIPILFRRSARWKSFRCSTGRRGPAFVDVSYEDPNNGVLEEQSFEFNDKSVATGRFVVALQDANRRQSDSKRRLFAKTERCPRFRSRIPSRDVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXA9</accession>
    <name>A0A398CXA9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon-phosphorus lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05218">
        <property type="protein sequence ID" value="RIE05218"/>
        <property type="gene ID" value="D3H35_01475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019634">
        <property type="term" value="P:organic phosphonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008773">
        <property type="entry name" value="PhnI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05861">
        <property type="entry name" value="PhnI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007313">
        <property type="entry name" value="PhnI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="385" mass="42689" checksum="23A78B0C74ACFF05" modified="2018-12-05" version="1">MGYVAVKGGTRAIEESLRRLQYERLREGRAIDVDSVRMGMRGLVDQVMSESSLYDETLAALAIKQAEGNPEEAVFLLRAYRSTLPRKHYSLAVHSAEMRVERRISASFKDIPGGQILGASADYSHRLLDFDLIDETESTIRDWLREFRSAAKTDQAARSSATGSDRLPKVLDYLRKEGLIAACPANDAEPNDVTRTSLAFPASRSEKLQILTRGQTGAVTSLAYAVIRGYGMVHPTVGELRVGQLPVYVSPPLDVDGEDEDSYYIGEIKVTEVEMLIPAVAEKEQGRKELELDFGYGLCFGQNETKAIAMSILDKSLEGGDKSIPTQNEEFVLYHIDSVESTGFISHLKMPHYVTFQSKLNDVRKTRQAQPTEEPQGGNVYANSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D085</accession>
    <name>A0A398D085_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_05310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04881">
        <property type="protein sequence ID" value="RIE04881"/>
        <property type="gene ID" value="D3H35_05310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026838">
        <property type="entry name" value="YheC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38437">
        <property type="entry name" value="PTHR38437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14398">
        <property type="entry name" value="ATPgrasp_YheCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="143" mass="17304" checksum="0DCB0CDDD0952ACB" modified="2018-12-05" version="1">MQEVRRLKSTARKNVLSKWLKTKAILKDPKVRRVVPETHRMNEKSLREMLSRYSMVYIKPEAGTYGKGVMRVEQDNGSYWYQKEEKKRAFDSFSSMYRSIVRNKRKRPYLVQKGIHLLKYKGRRFDIRVMVQRNRKLAWEMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0H7</accession>
    <name>A0A398D0H7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplD</name>
        <name evidence="8" type="ORF">D3H35_02245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE04991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04991">
        <property type="protein sequence ID" value="RIE04991"/>
        <property type="gene ID" value="D3H35_02245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="207" mass="22169" checksum="54985B54533B3C3A" modified="2018-12-05" version="1">MPKVAVYNVDGGQVGDIDLAEGVFGIQPNTHVLHSAVVLQQAAVRQGTHKTKGRSEVRGGGRKPWKQKGTGRARQGSIRSPQWKGGGIVFGPTPRSYGFKLPRKVRRLAIKSALSSKVQAGTIIVLDQLNFAAPKTKEFAKILGNLKVARKALVVTADFDNNVALSARNIPGVKFVAADGISVLDVMVHDQLIITKDAVAKVEEVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0V7</accession>
    <name>A0A398D0V7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pyruvate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_04870</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04804">
        <property type="protein sequence ID" value="RIE04804"/>
        <property type="gene ID" value="D3H35_04870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="POR_N" evidence="8">
        <location>
            <begin position="31"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="10">
        <location>
            <begin position="280"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="9">
        <location>
            <begin position="550"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE04804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="769" mass="85045" checksum="53235C2E0AAE63A9" modified="2018-12-05" version="1">MAIDIRKEMGPKGTVEQRIVYESGNEMAAYAAHQINYHVMGYFPISPSTEVAQFLDLMKANGQHDIVLIPADGEHGSAGVCYGASVAGGRVFNATSANGYLYMLEQMPVQSGTRFPMVMNLVCRSVSGPLDIHGDHSDLYFALNTGWPIILCRDPQAVYDMNIIALKLAEDPEVRLPVLVASDGYFTSHQKRRVHTFAHREDVLSFVGEKPPEGFVHVLDRDNPITVGPYMNEPDYINNCYQQSMAMYRAEGVYDRIRQEYAALTGRDYPLLELYRMEDAEVAVFLLNSSAEIIKDVVDQLRAKGVKAGSISPNIIRPFPAKAIAEALANVKAVTVGDRADAFGSHGGNMVLEIKAALQTYRNHSTLVVSRIYGLGGKDFYAEDGLQMFEYALDAVAKGVVEKPFDYHGHTPGDPSKAPKRVLEPMKYEELKTGLITVTPDEETGKVNVRVPPLRQLTKKPKRIAPGHGACPGCGIFSGLELFFKGIEGDMIALFHTGCAMVVTTGYPYSAHKATYIHNLFQNGAATLSGVVEMFHERKRRGELDYLGLKDDFTFVMITGDGGMDIGMGPAIGAALRNHKMIILEYDNEGYMNTGAQLSYSTPIGHRTSTSNVGKQQGGKVFHHKDTAQIMAATNIPYVFTGSEANAPDLVKKGAKAQWYAQNVGMVYGKILITCPLNWLSDDKDGATIIDQAVNSCFFPLYEVERGVTTITYNPEEKGKRVPVSDWLKTMGKTKHLSRPEYVDTLRDFEGEIERRWNMLKAKHENPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D136</accession>
    <name>A0A398D136_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_05325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04884">
        <property type="protein sequence ID" value="RIE04884"/>
        <property type="gene ID" value="D3H35_05325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="77" mass="8869" checksum="EC90380A12698B17" modified="2018-12-05" version="1">MNEKSLREMLSRYSMVYIKPEAGTYGKVSCAWNKTTVLIGIRRKKKNARSIRFHPCIGLSFATNANVLIWFKKESIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D2K7</accession>
    <name>A0A398D2K7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000012">
        <property type="protein sequence ID" value="RIE05304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05304">
        <property type="protein sequence ID" value="RIE05304"/>
        <property type="gene ID" value="D3H35_01265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="79" mass="8461" checksum="69A7E41AC89E6B6C" modified="2018-12-05" version="1">MRPILMTAIATVCAMLPLVFGTSESGSIVSQSLAIVVIGGLIVATLLTLVIVPCIYELLFFRKSKRQRVAKAKQQTIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D316</accession>
    <name>A0A398D316_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_00035</name>
        <name evidence="9" type="ORF">D3H35_08940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S1C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000001">
        <property type="protein sequence ID" value="RIE05484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04063">
        <property type="protein sequence ID" value="RIE04063"/>
        <property type="gene ID" value="D3H35_08940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05484">
        <property type="protein sequence ID" value="RIE05484"/>
        <property type="gene ID" value="D3H35_00035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="428"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE04063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE05484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="523" mass="55826" checksum="4E57C708CD878ABD" modified="2018-12-05" version="1">MDDQNKKPEEWNEFPFGPSDRKEDNGFRQESEDSFAETRREPETYTYGPFGGTSAYSSSNDRLEPTSEQGQEPVEVVASSREYRPFTVSGGGGGGRGGWDGAKPKRTSFRGIFSAFMVGVVAVGGLMFAADRGNWFGNETYVSNASTQNSGVKAASTTVNNAADVVRPNNIAKIFEQSSPAVVKIETYTNVRTNSRSNNSMFDDPFFRQFFGDDGSGQDGNNGSNGNNGSNGTDGTLQESGMGSGFIFDSTGYILTNQHVVADADKIEVTVIGHNKPFTAKLLGSSRDLDLAVLKIEGATFPTLKLGDSGSANMGDWVVAIGNPYGFDHTVTVGVLSANERQISIQDTEGQRNYEHLLQTDASINPGNSGGPLLNLNGEVIGINTAVSSEAQGIGFAIPTSTITDVLENLKSNTQIPKKPVPFIGAKLTAITSDIAKKLGIDTTKGSIVSNVVYGTPAYRGDLRQYDVITGMDGTSYNTPDDLIAAIQKKAIGDKVTLNVIRGGNKIDVKVEVGNKNDFEDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBQ7</accession>
    <name>A0A398CBQ7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maltodextrin-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_29710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the bacterial solute-binding protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00213">
        <property type="protein sequence ID" value="RIE00213"/>
        <property type="gene ID" value="D3H35_29710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006060">
        <property type="entry name" value="Maltose/Cyclodextrin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00181">
        <property type="entry name" value="MALTOSEBP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017101639" description="Maltodextrin-binding protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="435" mass="47131" checksum="0D5C1F7E2C20B21C" modified="2018-12-05" version="1">MKKILSLVVVLSVIITLTACGEGTENKPDPDKEPSSTNSPSNEQPDSHSPEPNAHLTVWASKEELTYVNAMSVQFTQLHDIPVVVQEVGAGDVLNKLTTDGPAQIGADLVTLTHDHLGEAVAAGLLLPNDIWQDETKRNNQENVLQAASYGNILYGYPLSLETYVMFYNKKLVSTPPSTFDEVIDFAKTYNDPGKGKFSLMWEMENLYFNYFFLATTGGYIFGNKGVNYNDIGINSEGAIEGAAYYGSLRDKLLPLKSGDVTYDIKKGQFLDGSLAMNIDGPWLIRELRAQGNTFGAAPIPSINGKPSVSLSSVKAWYVNSYSKYPNAAKLFANFASSKESQLKNFQLTGAVPSNLDAMKDPAVQQDEFVSAIIKQIEFSQPMPSIPEMGSVWIPVNSAMSDIWNKGVDAKQALDKAAGQIKDSIAVGSSGGGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCU1</accession>
    <name>A0A398CCU1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00235">
        <property type="protein sequence ID" value="RIE00235"/>
        <property type="gene ID" value="D3H35_29820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="174" mass="19801" checksum="7ABA4E63A1DCC1DE" modified="2018-12-05" version="1">MGAAFRTLFWGFIFLFDFRINGLDILPDVVAYYCFYTGLSRLVVVSPRFEEARKFTLPLLFLSIPDINPAWFSFSGILMLIYVMALTVLNLIMVYSICMGIKEAAAARQDQDLADTAHSRWTFFLIAALAVIFTQLLAMGSAVSAVWAILIFFFSLVVYVLFLDLMRKCETRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD45</accession>
    <name>A0A398CD45_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_29140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000057">
        <property type="protein sequence ID" value="RIE00335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00335">
        <property type="protein sequence ID" value="RIE00335"/>
        <property type="gene ID" value="D3H35_29140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="160" mass="18707" checksum="C9450DA147E7D125" modified="2018-12-05" version="1">MVSQIHSLVEESYRGKILLQQSELKALQAQINPHFLYNTLESINWMAKMNGVDPICGMVTALGDLMRISINTEKEFITVEEEIKYISDYLYIQKVRFGDRVQADIRMEDELLPIVIPKLILQPIVENALLHGVQMKKRPRVNSGPREKSRRRRYYFRSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CE44</accession>
    <name>A0A398CE44_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_24095</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01446">
        <property type="protein sequence ID" value="RIE01446"/>
        <property type="gene ID" value="D3H35_24095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="10"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE01446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="404" mass="43415" checksum="9B1CF896C75B71AF" modified="2018-12-05" version="1">MSLLLKNRAALLLLMFNLFLAFTGIGLVIPVMPKFMTELEISGSVVGLLVAAFSLTQLLFSPLAGRLSDSLGRKRIILLGMIVFAFSEWLFGVADSPFVLFASRLAGGIGAALIMPAVMAYAADVTSNEERAKGMGFMNAAITTGFIIGPGIGGYIAEFGIRVPFYAAAVAGVVAAVMTALFLPESVVSSSDRSGMSGERTKKRDEHPNLLRQLARSYREPYFLSLVIVFVMSFGLASYETIFSLFVDHKFGFTPKDIAFIITFGSISGAVVQVTLFGRIIGRFGERRVIAACLLSASLFVFLTLFVSSFWMIFAVSFIVFLSVDILRPAVGTQMSLLAENQQGYVAGLNSAFMSLGNIVGPVIAGALLDANINYPYLLASFILLVSFLLSIGANRGVRKSVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEK1</accession>
    <name>A0A398CEK1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Haloalkane dehalogenase</fullName>
            <ecNumber evidence="3">3.8.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_24950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.8.1.5" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01596">
        <property type="protein sequence ID" value="RIE01596"/>
        <property type="gene ID" value="D3H35_24950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018786">
        <property type="term" value="F:haloalkane dehalogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="55"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="321" mass="36844" checksum="E726246733529001" modified="2018-12-05" version="1">MIRSEYQPTTPKKGATPPMSNLEALPIGKEYPFESRYMTVNGHRLHYIDQGTGDPVVFLHGNPTWSYTFRNIIPYAQSSNRCIAVDLMGMGRSDKPDIGYTFLEQVDYVTRFIEQLELTNIVLVGHDWGAAIGLHYAMNHPDKIKAIAMLEPQALYPNPTWSDFSPPEAQPLFQTLRDPEKGWPFMRDNSVFIEGMTTTIINRAISPEEHEQYREPFRNPEERKPMWVFPNQIPIEGHPPEVVEAVNARNDWFTASPIPKLLFYATPGCTVREPQLDWCRKHLHNLTLCDIGKGFHYLTEENPHAIGRELRRWLDQVNGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF92</accession>
    <name>A0A398CF92_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01393">
        <property type="protein sequence ID" value="RIE01393"/>
        <property type="gene ID" value="D3H35_23785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="72" mass="8081" checksum="2400ED4D5530D5DC" modified="2018-12-05" version="1">MGAGIAFFSNTHPIPTQSFFDVQRAGADAGLLGIRAYYVKDILATQSHFFKKAIRHRRGAWSRLFLKVRVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFU3</accession>
    <name>A0A398CFU3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_26635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00772">
        <property type="protein sequence ID" value="RIE00772"/>
        <property type="gene ID" value="D3H35_26635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="71" mass="8732" checksum="365230819D2F595D" modified="2018-12-05" version="1">MEKMAMNMMMSMCMEEMMCKMKCMKMMMDQMMEMKMMDSMDMDMMMAKMQECDEMTTMMMSMMRDMKQMSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG38</accession>
    <name>A0A398CG38_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YheC/YheD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01425">
        <property type="protein sequence ID" value="RIE01425"/>
        <property type="gene ID" value="D3H35_23965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026838">
        <property type="entry name" value="YheC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38437">
        <property type="entry name" value="PTHR38437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14398">
        <property type="entry name" value="ATPgrasp_YheCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="255" mass="29808" checksum="07B13DC859D8544E" modified="2018-12-05" version="1">MRIQRVLSKWAKTETLLKDPAVAEYVPVTSHFNRLTVKELLDRFEMIYVKPVQGTFGKGVIRLEKRTEGAAPYFFQSGEKKYEFLSFDEMYDRLVAVKRKRSYLAQQGIPLLKHKGRRFDLRSMVQKNPANRWETTGLIGRLGHPRKIVTNYHSGGTPLPIERLLATHVPDHVLPSYLNGIRKLSVQVAASLEKRYPRIKEIGIDFAIDEQLKPWILEVNTLPDPYIFKKLPSRSVFKRIYSYCVAYGRFRRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGD0</accession>
    <name>A0A398CGD0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_16250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02276">
        <property type="protein sequence ID" value="RIE02276"/>
        <property type="gene ID" value="D3H35_16250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="133" mass="14972" checksum="B6EABE9D1802209E" modified="2018-12-05" version="1">MRTEELTSWGWATESADVRTEELTSWGWATESADVRTEEITGWSWATESANERTEELTSWGWATESANERTEELTSWGWATESADVRTEELTGWGWATESADVRTEELTGGGWATESAECISAERQSVRYTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGG0</accession>
    <name>A0A398CGG0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_24655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01545">
        <property type="protein sequence ID" value="RIE01545"/>
        <property type="gene ID" value="D3H35_24655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="240" mass="26512" checksum="D5CFBAEC86FE8A4F" modified="2018-12-05" version="1">MFEVDNLSKVYPGGRGFQGLNLTVLPGEVVALLGPNGAGKTTALQAMAGWLESDRGNARLDGASVADQPEQTRPHMGLMIGEPTPYSYLTGYEYLRLYHKLYPGIDEARIRQTIELVGMSKHHGLKIKKYSTGMKQRIELASALLHRPKLLLLDEPFSGMDIEGRREMATILHSLVAETGMSIIVSSHQVHDIEDWITHACIIFEGRHIGTASVAQIRESFPSVEEYYLHGISQERSGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGL6</accession>
    <name>A0A398CGL6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_29740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00219">
        <property type="protein sequence ID" value="RIE00219"/>
        <property type="gene ID" value="D3H35_29740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="382" mass="42893" checksum="0AB68180472F4CE7" modified="2018-12-05" version="1">MKVILVDDEPVMHLIMRKMLVKHPELQVTGEFSDTRSAAAFLSEHADIDLAFVDISMPGDNGLSFAAKLEETGCLTQIVFVTSHKDYALKAFELSVLDYLVKPVTQERLERTVHRALASKKSVRAPSAYSAAKGTSQISIATLGDFSVRNEIGRVKWISSKSAELFAYLLLNRGRRISRARLVADIFAGMTQVNAEKYLNTTVYQLRKSLEPIGLREAVRSENDGYALELKDAVIDCEEFERQAGKLGNIEADNVDMALSVERLYTGDLFGSKAYVWAIYETERLAERYSSFVKRLSEALISQQDLAAASKLLLKLYARNPLDESVVRLLMKKHEQDGDKKGLTAIYTDYVKLLNRELGIRPSQELLLLYDSLVSRLPDSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGQ5</accession>
    <name>A0A398CGQ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01923">
        <property type="protein sequence ID" value="RIE01923"/>
        <property type="gene ID" value="D3H35_14185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="81" mass="8987" checksum="C34B29DD3D9F7913" modified="2018-12-05" version="1">MKAEVTRGSSPLSEAQVVFEIWPKGAGPESHAQLLAKPGESKGSYELKGEFARERRTTFITHITPEDTGQMTMASFEFEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGV9</accession>
    <name>A0A398CGV9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PspA/IM30 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_14535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01983">
        <property type="protein sequence ID" value="RIE01983"/>
        <property type="gene ID" value="D3H35_14535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31088">
        <property type="entry name" value="PTHR31088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="87"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="222" mass="24959" checksum="265CEBC3A3E9C1D2" modified="2018-12-05" version="1">MSIFKRLRDLTLSNVYALIEKAEDPVKMTDQYLRDMQDDLEDAEKAVAAQIALEKRFKQLFEEQSALVQKREEQAHTAARAQNVDLARRALEEKKSAEQKASEYKASYDQNKASADLLRAKLDDMRKQFTELKNRRETLVARANAAKAQAEINKAMSGFGSDTALSGLKRMEDKVMQMEAHAEATEELNSAKGKSLDEEIAALGKDQAVEDELAALLKKYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGW2</accession>
    <name>A0A398CGW2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02446">
        <property type="protein sequence ID" value="RIE02446"/>
        <property type="gene ID" value="D3H35_17225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="7"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="240" mass="26948" checksum="5348CD73D86A1B9C" modified="2018-12-05" version="1">MKYGKIIGEGNTATVYEWEEGKALKLFVPGYPQDAAEREFHNAKAIHGMSFAKPQVYDMIGCEGRTGIIYDRVEGESLLDWVLGTGDLQSCAKYMAKLHKTIVQHEVSNVPDYKSFLKSNLLNAPSVHLTEQEEALEILDTLEDGDTLCHGDFHPGNILLSNGQTTVIDFMNVCHGHFLYDVARTVFLVEYTPVPVGAEDREMLLRFKKTLADLYLIEMNVTRPMIQDYLSVIITARAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGX1</accession>
    <name>A0A398CGX1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01705">
        <property type="protein sequence ID" value="RIE01705"/>
        <property type="gene ID" value="D3H35_12900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="147" mass="16336" checksum="32273D7EE5E0E770" modified="2018-12-05" version="1">MNERFVKHSTFVVERTYAASPERVYHAWADPVAKAKWFSKADVFDFRVGGREYSSGGPPEGPIFTFDASYQELVPEQRIVYTYTLDSGGTRISVSITTVELIEVEGGTKLIFTEQGAFLDGHDTPEIREHGTNLMLDALGKAVEGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH08</accession>
    <name>A0A398CH08_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PKS_ER domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_13145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01745">
        <property type="protein sequence ID" value="RIE01745"/>
        <property type="gene ID" value="D3H35_13145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="4">
        <location>
            <begin position="8"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="344" mass="36805" checksum="F3F4819DC03554EC" modified="2018-12-05" version="1">MKRAVLIGEKLMEVQEAARPAIKANEVLVENEVCGICGSDLHIYGGNHPVLKPPVSMGHEFAGRVVEVGADVRSIRIGDYVCAIPGVGCGKCEPCQAGKFNLCRELKVIGGLYPGGFAEYTAVPEYNIVKIPELFSATDGAMVESAAVAVHAVSRMKSVEGKKIAVLGAGPIGLLIIQVLKAFGAKLVVASDPIESRRDIASRLGADIVIDPTKENVEERIQAEVGGIGLDGAFDVAGIELTLGQALAVTKNGGEIVITALFSKDPVFPMKMLQRAEKTLLGTQMYVKQDFETAIQLMQENKIKIDEMVTHRFDLDQISEAFKLATSGAHHVGKMVIDVKKQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH11</accession>
    <name>A0A398CH11_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_28525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00369">
        <property type="protein sequence ID" value="RIE00369"/>
        <property type="gene ID" value="D3H35_28525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="251" mass="26593" checksum="9E6BD1DA9B01CFF0" modified="2018-12-05" version="1">MGGRLQNKVCVVTGSGGGIGAGVARRFAEEGAVVYLLDYNEEKLSATVGAFKNLGLDAEGILTDVGEEKQIKEAFAIVAGKHGRLDVLHTNTWWAAKKKAADLTLEEWNKALSITLTAPFLCSKYAIPLMSASGGGSIIHTSSVGGVVAFREHADYISAKAGVIQLCKSIAVDYGSERIRCNAVCPGIIDTPQTRSDLEDPDYSNYLMSKCLNGRIGQPEDVAAASLFLASDEASFITGSVLMVDDGWSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH16</accession>
    <name>A0A398CH16_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_13205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01755">
        <property type="protein sequence ID" value="RIE01755"/>
        <property type="gene ID" value="D3H35_13205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="799" mass="91979" checksum="930E9D681448C245" modified="2018-12-05" version="1">MKKEELEPESIHLLREHGISWDGTKSVYMTALHKNFYLKEAELRSDAVLKEFCDLIVYLKTHPEYGVSTDWASSELNRYVYMNNKEAMKTGFPSTIEALSRFYDDSSIIRFYKDQGAKAPTIIDLIGTTGAGKTTFCQQFVDDSSKDLLKLTITDSAESTVMQTDILILQQTSKKMFLRARSKADIMKDIMTVALELDLTASGATIKELVKKNAEIIDKDMIDKVSHFFSTDALVGKFTAFADQVQTAFKADAVGETARLKWIKEHSADSGFVYILDDEVANRFPTSYFYGYLQEYDLETDADFNIVRTITNTEFKYRKEDLEDYPEMADAVSDRLLFDHAILVLPCSAEAQDKLEYDFQQGIVFRDSQGHKLDEQNGIASDFEVKNKIFLIPIDTGGYLIDDRYSNIFERILISEPKNNVFVLTKVDLNTTYKRYKDSHYLKNKDFNRVFSDKIARTHNKLISTFQNQQAAKDNGDGQSKFYKDETALFTNFMASFSNAYLSEIDGDTFAAEGHKIAYAGQALEELDRSKLDIEYLESWFDIVGGIIKENKLTYHDNIVRIANPAPSKRLDFVERCKGTVKILMDYYISTQKWQDEIDGQLAVFNVDFRTVYQKGDVWYRSNFINDGNTTASNSYFKDLTRQIVKDINSYVIKGTTTNYVKSKLQEPLTDYLTTLYSSKKGDSAVVLNSLSNKIIQNSLERAAKIAYKVFDRKTKDHYFMDNIRDIFKGSEEYFTKPKKITLREVERARRAYSTYTEHYAGIYGYLLARHTYNLETYFLAIFQTVIESELHELNEKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHC5</accession>
    <name>A0A398CHC5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_13945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01880">
        <property type="protein sequence ID" value="RIE01880"/>
        <property type="gene ID" value="D3H35_13945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017323174" evidence="4">
        <location>
            <begin position="36"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="5">
        <location>
            <begin position="734"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="5">
        <location>
            <begin position="799"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="858"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="858"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1041" mass="111309" checksum="8B9CB2B5D2E156FA" modified="2018-12-05" version="1">MTTKRMKKLCAATAFLMLLLSAGNAVGNVSGTAFAADDGSPVVNFPDANLKKALLEIGVDTNKDGQITQAEMAARADPYHMATGLASLGLGNKNIKDLTGLEYAVNVRTLSLSDNPVTDLTPVAGMPSLESIGLSNTPVRDLSPLGQLAELRFMEIRNAKSLDLSTITSLTHLEFLYADQSNLRDIGPLASLTKLKVLHLFNNQISDISPLANLSDLREVSIRLNKITDIAAFSNKPYMHTLWLSNNQIGNVGGLTNVPSLSWLELDYNRIRDISSFSALTNMRELNLDYNEISDLSPLTGLTKLEKLGAYGNKIESVSPLAGMTKLTNLYLGENRIQDIAPLASLKALKELLLGKNPLRGIGALKNLTGLTSLSLIETKSSDIGALAGLTSLKELNLPNNSISNIAALAGLTDLKELNLQNNSISDIAVLGNLENLTGLWMDGNPTIRDASPILKLSKLTDLKLDKNVASSIAPVVTGVADGIYNTDRVISFNRGTATLNDKPFASGTTVSEEGAYSLYVRDQAGLDKDIHFVIDKQPPVVTGVVNGATYEQAVSITYNEGKAALNGKPLGNGATVGEDGAYTLIVTDEANNSTTVRFTLLQSGPKVRGVASGGLYNTDKVITFDQGTATLDGKPFANGGTVSEEGVHTLVVTGKDGKVTKIVFTIKKQGGDGQTVDIGELRGVSDWAKPDLQYAGRIGLTLPVQSDLFSDSVTRKQFSAIAVKLHEALTGEKATAASSNPFQDTSDPEILKAYRLGIVKGTSTDKFSPGALITREQLAAMLMRVVDQSGKKIPGGTAKVFTDRSKFSSYAAEAIDYMSSIGVISGLTPTTFGPKKNASIEQAVIMAKRLHSLLTEQSAAESGSTGSSSGDGQDSPDPGQSGGTESLYAFDATAFELYVKKTNPQPDGGLYKEYAIRNARSLTLPPYSAIYLTAGISYQAFENESYKYNFGGSVLVANHTDKPMVVAAGAIDYSVSSIYRDDMGTVTFPDGKSQKLTPTGPYLRLIAFDGDFDESKEYKDYLDLKKDLYRGDWMTVKLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHD9</accession>
    <name>A0A398CHD9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_28210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000054">
        <property type="protein sequence ID" value="RIE00499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00499">
        <property type="protein sequence ID" value="RIE00499"/>
        <property type="gene ID" value="D3H35_28210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="107" mass="12200" checksum="6F7412E628967B01" modified="2018-12-05" version="1">MVAGEAEDGEDGLALVEETRPHFIITDIRMPGMDGLVFSKTVKERYPEVEILMLTGYQDFEYAKTAMHIGIRDLLLKPTKFDELEKAVRKLIVDIRDREMSRANTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI31</accession>
    <name>A0A398CI31_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA alkylation repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02453">
        <property type="protein sequence ID" value="RIE02453"/>
        <property type="gene ID" value="D3H35_17265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="235" mass="26379" checksum="462493C344430424" modified="2018-12-05" version="1">MNLETVMQELEALGKERTKKIYVSNGAHEPLFGTATGEMKPIAKKIKLNQPLAEQLYATGNYDAMYFAGVIADPKAMTEADFERWIDAAYFFMLSDYVVAVTLAETDIAQKVADQWIASGEELRMSAGWSCYCWLLGSRPDSEFSESKLADLLERVKNTIHSSPERTKYAMNNFIYTVATSYSPLHDQAVATAKTVGPVEVKKDKKKNSFLNASENIQKAVDRGQLGFKRKYVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI53</accession>
    <name>A0A398CI53_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02120">
        <property type="protein sequence ID" value="RIE02120"/>
        <property type="gene ID" value="D3H35_15285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="373" mass="42335" checksum="E97CFC456C290C1B" modified="2018-12-05" version="1">MTMDAHTPPPTAVASFPCPGCGGSMQFDTESQALKCQYCGGERTIEHLMEEPREHPFAEEEDSAELLDWGTEQQSVRCESCGGESLIPLRQTATQCAFCGSPKVLPQGEARSGIRPESVIPFHVSLDGAAELFRKWKGKRWFVPNAFKKQNISSKLNGIYIPYWTYDTSTYSVYSAEVGIYHYRTETRTRVVNGKSETYTEQVRYTVWHWTKGDYDRAFDDILIPASGYYDKDLLRKLGDFDLGRLTGYKPEYLSGFIAERYSVSKSQGWTYAQAEADDQIRDDVRRQIGGDEIRNLNIRTNYGDITYKHLLLPVWNATYSYRSKSYRYMVNGQTGTVSGRVPRSPWKITFFVLACLAAAIGALWIYGNSQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI87</accession>
    <name>A0A398CI87_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-4-amino-4, 6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.202</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pseH</name>
        <name evidence="2" type="ORF">D3H35_15030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.202" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02075">
        <property type="protein sequence ID" value="RIE02075"/>
        <property type="gene ID" value="D3H35_15030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020036">
        <property type="entry name" value="PseH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03585">
        <property type="entry name" value="PseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="181" mass="20864" checksum="A90D7B0D0FF62AC8" modified="2018-12-05" version="1">MVPYNDYSIRPLLESDLRMVLQWRNSERVRANSFSDERIEWDSHYAWFCRLQTNPAHRYYVVELGNKPIGVVYFRNIDGTNKKCEWGLYLGETTAPRGSGTIMGALGLSTAFGHLGIRKICAEVLAFNVPSVRLHERLGFLQEGCLSRHVWKNGKFEDVVLYSIFSEDWAAQQEGMTRIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIN0</accession>
    <name>A0A398CIN0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_26340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00718">
        <property type="protein sequence ID" value="RIE00718"/>
        <property type="gene ID" value="D3H35_26340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="157" mass="18048" checksum="ABDA1A74245AE243" modified="2018-12-05" version="1">MERFGDWLLMLVAAGFMIGWVLWRLRRWLHDPPGAKLRGLARAGGIEVEDNDAVALLEEHGYEVLSGKHRIPLGVVLDDGPPQPTRLYFDYLASKEDKYYLVKLERARQPTDWTASGLRERLLVYQLLFPDCDGIVVANPNERQVRKVRFQVEDGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIY1</accession>
    <name>A0A398CIY1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02683">
        <property type="protein sequence ID" value="RIE02683"/>
        <property type="gene ID" value="D3H35_18660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="98" mass="10764" checksum="A64F013D86336A6F" modified="2018-12-05" version="1">MTAFMAIRSLAAGSIGVEDDPTNNGVGTDSIEKRIKFGALGERVSFKPEWKSLFEEAMSNENPNPDRWLPIADKLASTPVAALFNIPSEVGLLFEYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ65</accession>
    <name>A0A398CJ65_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02152">
        <property type="protein sequence ID" value="RIE02152"/>
        <property type="gene ID" value="D3H35_15500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017483191" evidence="1">
        <location>
            <begin position="31"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="137" mass="14611" checksum="096B9A912E4FF337" modified="2018-12-05" version="1">MNPKQWLLSSTMAVAIAIGSSTTWSDDAKASPLTSKEAKLPTTISNIAAPTQDHLLHLLGATEDELYDALYNEKSLAELAASKQVEVSQIIELQVAEMTEQLEARLSSGSLSPAAYEAQKSELTEIITNSVYGGSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJB8</accession>
    <name>A0A398CJB8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02445">
        <property type="protein sequence ID" value="RIE02445"/>
        <property type="gene ID" value="D3H35_17220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="481" mass="52004" checksum="E5016DB77552D040" modified="2018-12-05" version="1">MRNNAVAFLWFGSLLILIGAALGAWSAAPALRASHPVAFAGQTYPVKEDGAAISAGTAVKPSDKPLSRVDCPKVYVDKMCVELPRLESTVELWLKKTENSAAEKFRTLAQVPANTRLYAASGVLLFAAGLQLVYEGWRRRSNKSPLSHPSLSRFQLLLWIAAAAAVYAALSVPRLDWRIGVLPQHFWLLASACVTRMLSKLVDWRKLGKLGAPIDRALDELKAYALSHPPKSGEDQLPSEVKAQLDAVKKAAADLPAGTITLVQFQQQLDKAVAALNASMPKPPDGTSAALQETLAPMPVHSLSLSPAQLQNYASTAQTAIDERTNQLLQAIAKEPPGWVKLLNDVEALAQAAKNEKTDPNAFFTALIKALSDFRTQGPGIIKQAESLFSRLAAWWKKGGVIGSLRGQNRKLSLSRIQYALSVCATVVYFVIQTVREGHLPALPLPAITTVSASQLVYLVAKWLGHSASLPQEQQHGKLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJZ5</accession>
    <name>A0A398CJZ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc-binding alcohol dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_20725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03023">
        <property type="protein sequence ID" value="RIE03023"/>
        <property type="gene ID" value="D3H35_20725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="26"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="171"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="339" mass="37081" checksum="ADA6A5BAC631C2D9" modified="2018-12-05" version="1">MKGIICEEVDRFRLTEHLPEPELAKGEAIVRIRRIGICGTDYHAFKGNQPFFSYPRILGHELAGVIEAVSEGAAGLSEGDTVAIVPYMHCGQCVACRNGKSNCCSSMKVLGVHIDGGMRERLAVPVSHLLPAHGLDLDQVAVVEPLAIGAHAVRRAEPKQGENVLVIGAGPIGLGVMAFAKYAGARVIAMDVNKERLQFCRSWANVDAVVNALNNPLEALSELTGGEYPTIVFDATGNARSMTDSFQYVAHGGKLVYVGLVKADISFNDPEFHKREMTLMGSRNATREDFEYVLKALRSGSIDVERYITHRAPFDDMIGEFERIWLKPESKVIKAMVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK27</accession>
    <name>A0A398CK27_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_22750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01218">
        <property type="protein sequence ID" value="RIE01218"/>
        <property type="gene ID" value="D3H35_22750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="5">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="214" mass="23630" checksum="83A205D47E622020" modified="2018-12-05" version="1">MITIVIADDQMLTREGLKTILDLEDDIEVVGIARNGAEACELAARLHPTLVIMDVQMPEMDGLTALKQIKQTIPETFVLILSTFLDDNYIVDGMANGASGYLLKDMDVDKMIAAIRDTVSGQFILPSAVAAKLATRMTQMALDRPSAAANHQSVQLTDREKELAELVMKGYSNREIAAAMYISEGTVRNYISNLYGKLEVMDRVQAIVRLQTFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKE4</accession>
    <name>A0A398CKE4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="6 12">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D3H35_18240</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="6 12"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02622">
        <property type="protein sequence ID" value="RIE02622"/>
        <property type="gene ID" value="D3H35_18240"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="GlyclTrfase_39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="Glyco_trans_39/83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="PTHR10050"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="14">
        <location>
            <begin position="61"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE02622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="602" mass="69103" checksum="F619E63072EBA4AA" modified="2018-12-05" version="1">MEFQNNAGASPVHWGRSGSSNDSRREERRWKPVDFILVGLLTLAAALMAFTDLGNRTGPQTYWKPDLSGEGFVVDFGQPRQVDRLNLYEGPGAKGQTKIEMSLDGKTWLPYQSIEHSTNRVFTWKHEKDTRVDARYFRFTAERTGYRLYEAAFYTNGVTVPIPVESIEPIGTKGAESEGGGEQLFDEQQWAPERADYRNSMYFDEIYHGRTAYEFVEGMEPYENTHPPLGKVLLAIGVKLFGMTPYGWRFMAAVGGTLMVPLFYWAARGYFRRTRYATLATLLLVMEGFHVVQSRMANVDIFGVTFTIVMFYAMYRFGETAWRNGGLWRGIGYLALSGLFFGMAASVKWNYLYGGAGLAILFFLALIRRIGEARSDSEGGIAKRALVTLVAAAVFFVALPASVYTVSYIPYERATKVDDNWKDLWQYQKNMYHYHKGVKEQHPYASKWYTWPLMLRPVWYYGGKDLAPGDAQSIAAIGNPVVWWVGLLAFIASWWFGIVRRRDRVVLTLTVAYLSFYVPWMVAPRSITFLYHYFPMVPLLILSLVWMLQRVEESFRYGNRVTWIVVGGAAALLVWFYPVYTGITISREWMNIWIRWLPSWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKM7</accession>
    <name>A0A398CKM7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_20140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02925">
        <property type="protein sequence ID" value="RIE02925"/>
        <property type="gene ID" value="D3H35_20140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="72"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="277" mass="31362" checksum="045433341217FC3C" modified="2018-12-05" version="1">MHTKESRGNFSFFIMFLLMLAFISPILIIFMNSFKGKFYISDTPFVFPNKTTYVEFDNYVSGIAKIKFMNAFGMSVFITVCSVFVIVFLTSMTAWYITRVKSKFNQLLFYVFVFSMIVPFQMVMFPMTKVVNVLHLDNPYGIILIYLGFGAGLAVFLFTGFVKSIPIEIEEAVMIDGCNPIQAFFKVVLPILKPISVTVAILNVMWVWNDYLLPYLVIGSEYKTIPIAIQYLKGGYGSIDMGAMMAMLVLAIVPIVIFYFFCQKYIIEGVVAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL30</accession>
    <name>A0A398CL30_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000057">
        <property type="protein sequence ID" value="RIE00331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00331">
        <property type="protein sequence ID" value="RIE00331"/>
        <property type="gene ID" value="D3H35_29115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="71" mass="7672" checksum="B9D28E492A92400B" modified="2018-12-05" version="1">MFKLAKDFSLDLEAVAKGGVSWDDKLDPASNEVVGSTANELALGLITPEEFAEKVDKAIGRNAPSFFKDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL43</accession>
    <name>A0A398CL43_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_20420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02970">
        <property type="protein sequence ID" value="RIE02970"/>
        <property type="gene ID" value="D3H35_20420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="210" mass="23143" checksum="AB99DD1F9210D0F5" modified="2018-12-05" version="1">MVVILLCTDKYRKSDRTYGKTPEFDEQQALAAAMQVFLEKGYEASSISDLTSRMGIQRPSLYAAFGGKKELFEAALNKFAQMSLSFIENGMRNAPSVKEAARTYFQGIIEGVGGSKPELGCLCVNTMVELAPHDKIYAQFTKDYQTKLTELFRQTIENGIRTGELSNRLNAEAVARALTISAIGLSVTMKTGPDRSYVENATAEILSLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL49</accession>
    <name>A0A398CL49_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional repressor NrdR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">nrdR</name>
        <name evidence="10" type="ORF">D3H35_20125</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NrdR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02922">
        <property type="protein sequence ID" value="RIE02922"/>
        <property type="gene ID" value="D3H35_20125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00440">
        <property type="entry name" value="NrdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003796">
        <property type="entry name" value="RNR_NrdR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30455">
        <property type="entry name" value="PTHR30455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00244">
        <property type="entry name" value="TIGR00244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ATP-cone" evidence="9">
        <location>
            <begin position="49"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="zinc finger region" evidence="7">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE02922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="151" mass="17860" checksum="136DC0EAABF5CCA1" modified="2018-12-05" version="1">MRCPYCDYNGTKVLDSRPANDNKSIRRRRECEKCARRFTTFETVEETPLIVIKKDGSREEFSRDKLLRGLLRACEKRPISVGQLEILVSDVERELRNTAQAEVESRIIGELLMEQLYHVDEIAYVRFASVYRQFKDINMFMKELNNLMNKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLA0</accession>
    <name>A0A398CLA0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">uppP</name>
        <name evidence="15" type="ORF">D3H35_08260</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 14"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04126">
        <property type="protein sequence ID" value="RIE04126"/>
        <property type="gene ID" value="D3H35_08260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00753">
        <property type="entry name" value="undec_PP_bacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE04126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="282" mass="31308" checksum="8E3B066B64E4CD79" modified="2018-12-05" version="1">MHWFDSIILGIVEGLTEFLPVSSTGHMILTNKLLGYEEVPEQLKTFEIVIQFAAILAIALVYRRKIAQVFGFGRPESATGLSVSAFPKKRLNLLHVALGIVPPLAAAYLFKDMIKGDAFNAAPVLWALVVGGIYMWISEALYDSGKIKRTAETMDDISYKQAFIIGLIQCVSALWPGFSRSGSTMAGGMLTGLSYRASADFSFFIAIPIMTVATGYELLGNIDQFRSGNIDIGFLVTGFIVSFFVAWIVVVAFLKVLQKIKLKYFAWYRFALAAFFWLFIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLB0</accession>
    <name>A0A398CLB0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YjcZ family sporulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_27110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00637">
        <property type="protein sequence ID" value="RIE00637"/>
        <property type="gene ID" value="D3H35_27110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010070">
        <property type="entry name" value="YjcZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09680">
        <property type="entry name" value="YjcZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01732">
        <property type="entry name" value="tiny_TM_bacill"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="31" mass="3264" checksum="9905AA16C18CB01F" modified="2018-12-05" version="1">MSGVVGGYGSSAAFVLVLFILLVIILRTGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLB9</accession>
    <name>A0A398CLB9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_12455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03463">
        <property type="protein sequence ID" value="RIE03463"/>
        <property type="gene ID" value="D3H35_12455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="7">
        <location>
            <begin position="128"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="128"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="226" mass="26232" checksum="3ED41D0769D93D09" modified="2018-12-05" version="1">MRRLLLVEDEPNFARFVQMELEHEGFDVTVSHDGREGLQLATEREWDLILIDLMLPGINGIEICRRLRSQHNKTPIIMLTARDTVMDRVAGLDSGADDYIPKPFAIEELLARMRALFRRLDDDETEQEGSVVFLDLTVDVPSRTVTRQGKTIELTKREFDLLLALLHHRNTVMSRERLLNEVWGYEAGVETNVVDVYVRYVRQKLDGPDKERYIQTVRGIGYMMKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLG6</accession>
    <name>A0A398CLG6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02029">
        <property type="protein sequence ID" value="RIE02029"/>
        <property type="gene ID" value="D3H35_14795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017339488" evidence="1">
        <location>
            <begin position="34"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="702" mass="77526" checksum="1274B7489CFA3C51" modified="2018-12-05" version="1">MKLQLTKNLIKVGLAGTLVFGSVTVSGVSSSFAATAVKSAIPAPLTIAKNVTAQVKNVELFTQDKGLYLVYTINYVNNGASTLQLDDYWAKIKTTSGKSFSIKVVDKDKKITTVAPKSNASITYYAAIDEGLTLKNLRVNLIKWDFNVAGYMKNIGTFDLAKGYAPAVAAYEPITIAAKETKLKTSIKTVQSSVDDEDRVIDISYVIENLNTREYKAATTQFYVMTPDGSIYSAVNSDLKDLVVKPKERKTISLKATLPIDVKATGLKLITGYQSEADGIFIPTAAYQVPKASEVVTNVVTKMTYDNYNIEILGYSRLPSGSQDALQANIKVTNISNDEQKVPSLKASWKINGVAQETKTPALIAVDSKLQLSKGESIQLAATIFIPYTLTLKDVSINLKEVVDEKTEETIGSFRSDKYNVYKTAVDSTAAFTRVGSKSNVELLKVRSKDDGKQVNIFGDLAVTNLEYRPNSLQKYGIYLKGKDGQIYPLAVGEYEGQVISSGRIIVPFTGKVPLAAKDNVMDLLITELLPNTGDASNKDNTVSSEIYSVTAEWTDSAPSTKFHNLAIGKYDFTFDKFYAYLDMSNYVSANGLKLDFEYTMVEDSNVDDMAGTYKLRFELEDQESAKVTFVKEFALNGKDKTDEFASSGTIKKTIQFNDPAILDKITNFQEYKLSIYYTINDQKVLLAQKTIPYFYIQWMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLM6</accession>
    <name>A0A398CLM6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_13220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01758">
        <property type="protein sequence ID" value="RIE01758"/>
        <property type="gene ID" value="D3H35_13220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="305"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="582" mass="65967" checksum="99B9D5558DBD9B2E" modified="2018-12-05" version="1">MNLITKMILLIAMLMIPVILLFTHSNRQSIDLVKSQIDLANESRLEHFLEEIEGTLEQFSSYSGVIMTDPDFAEFAGGSVPADRYQYAELMQRAERKLRLFSLSTRWVNRINLYFPQSRLAVSSDKQPVYDDAALAAKIDPNWRLRPVVVNGISKRAFTRYFVDPYAGYADLKEASIVIEVELMEDNIVAKLDSFKTKGINEPFLVTSKGDVVLSTTSDASMARRIIEASGLSADSRMKERSTIRLNGKQYLVYTFRSAMTDMFFVEYVPLEDILAPVTRARMQFYLTVGLLVLLGVAVAVVLYVNVQVPIRLLTRSVEKLKDGQFSVRVRSRTGPDFERLVSRFNDMAAEIQHLVEKVYREKIRSKEAVMKQLQSQINPHFLYNSMAYIISMVNMNRPSQAVHMSHELADYFRYTTRNSEMETTLGEELAFVTTYLSIMEDQLDKISHTIELPDSMLGCRIPRLLIQPLVENAIVHGLEEKLEPGHIRISGETDGEWYRLSVSDDGVGMASEELELLNLKLALPDPDGDSFGLWNVKWRLRYQFGEGSDMTVASSDSGGLTIALRWRERSDEAGDGNGGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLS6</accession>
    <name>A0A398CLS6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03210">
        <property type="protein sequence ID" value="RIE03210"/>
        <property type="gene ID" value="D3H35_19840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025618">
        <property type="entry name" value="YtpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14007">
        <property type="entry name" value="YtpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="98" mass="11047" checksum="90C3E0E68BE7F39B" modified="2018-12-05" version="1">MINILQWILGALILVASLLSVYNSFRSRRSVDARLRGLYASRMNMSMGLMLILIALIQMLLFEGSSIRVVVGSVFFLLGMFNLFAGIRNHSHFKKLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM04</accession>
    <name>A0A398CM04_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helicase_C_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_07235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04376">
        <property type="protein sequence ID" value="RIE04376"/>
        <property type="gene ID" value="D3H35_07235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase_C_3" evidence="3">
        <location>
            <begin position="367"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="665" mass="74043" checksum="E1BF40A94D673519" modified="2018-12-05" version="1">MDVKPSVERLPESIRKLIASSAIVRDRLKSGERLDEILSSRRWAAAWLSEERDRAEEPAVETLRLLLRTYAAEPFERENLERTAALHDRTSLSGAEIRVGTAKLRRSGVLFAVRKIGGEQLLYLPTDMYPLWERLLFRPTSEPLERDEAALVVPADAPFRLPLSLELLTCWSIIGSRGLSLTSKGVPGKPSAARVEAGLRLSSEELVRFGFSYPGSDQLAPQVALALDIGFCLGTLERENESIRIDKEGMDAWLSRQAIEADTALHRLAVNRYASAHRELHLAASIIASLQPFGWHTEEAFIAAGCDGEALDSWLGLLASFGWLQRGSLADRAAFRWSRELDFLKEPCCETNRAAMAGEEGCPSYIYVQPDAEIIVPPETGLADRWRLEKLADRVSADTLFVYRITPSSCKRASSAGYTAESVAEFLESRSGTPLPQPVSDLLRDCFGSLGQVWFQDVTLLRAADDRAADLLERDAALSGIIVEKIGSRDYIVRSEDVKAAIRMLEKLGLPPSEGGAAERAAKKEKSGASASKDVRSEGWIYCRHVLSFYEPDRFFPKPEELFPGMRDIPSVWIGESRTYHSSTCRQMIRQAIDWGASVRIIRDGKPAAFVPRLLESGEDDWRVQGWWKAFPDSEVLLDKEAVTVSSGDFSELMILIPSLDSERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMI2</accession>
    <name>A0A398CMI2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02449">
        <property type="protein sequence ID" value="RIE02449"/>
        <property type="gene ID" value="D3H35_17245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="439" mass="48448" checksum="2EBAC86AE0B44F39" modified="2018-12-05" version="1">MLFFRECKKILFSVTFLLLIAGALLMTSSEEVLDFSGQAIEMPKPGQESYGMQNKDIPEIIMPAALQSLYREFGINSYTAYPIGFYKKVKLNENKQRQMADILSALTGIPADKLQAAEGGAEDAGFSLQGGELKSQGDGRYTIDVPDNTSAKNDAPSQVAPKDGIAYDDFKAFMKRANNLIGGGSSYSETYLIGFGSVPITYEEAVESYKLTKERDRFTGAYARLFADYILIILSVMPVFVAVAVSLKDKRAGISELIYTRSVSSAKVIATRYSAILLCVMVPVIALSYISNATAWKLYDGMTLNYFAPLQYELGWILPSVMISAAIGLFLTELTNTPIAIAVQGLWWFIDMNQGIMESAGGYSLLRLMPRHNSLSRTQDFLDQLDSLVANRLLMAGLALILIAATIVVYEQKRRGRFDGFGVKKWFAGMVNRQNKFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMP2</accession>
    <name>A0A398CMP2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">M23 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_17620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02509">
        <property type="protein sequence ID" value="RIE02509"/>
        <property type="gene ID" value="D3H35_17620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="4">
        <location>
            <begin position="229"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="335" mass="35994" checksum="40523F81406BAD17" modified="2018-12-05" version="1">MKWHQRKFTFMVIPDANSSVIRFQVSSAAILAGIVLIAALGAAAVTSYLMYRGNSEQIGTLERKLSASANESDAVIAVKDDRIEELQSQLAGLSDQAKDVQSRMDALGKLESQLKEMAGIGGKDGSSAGNVPSANDEGDYSMDGGGTGGEELPVTEEAMDDLVDETSDFFAVLNEQLRLLKPQLEATQKAVQTHQKALAVTPTIWPTDSRRVTSLFGIRRDPFTHRAKYHAGIDIAADTGEPVYAAADGTVVIAEKDSTHGNYIMLDHGKGIKTRYLHLSLIGTKVGAKVKKGDLIGEVGSTGRSTGPHLHYEVNVNGSNIDPRPYLNADRRENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMS8</accession>
    <name>A0A398CMS8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02549">
        <property type="protein sequence ID" value="RIE02549"/>
        <property type="gene ID" value="D3H35_17825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="64" mass="7148" checksum="08F96926A65E3A7B" modified="2018-12-05" version="1">MTKNEKVNGANKGETNYQYDDLNRLKKVTEPSGKVTDYTFDAFGNRSSERTTQGAAVTVLLFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMV2</accession>
    <name>A0A398CMV2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_11065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03570">
        <property type="protein sequence ID" value="RIE03570"/>
        <property type="gene ID" value="D3H35_11065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044159">
        <property type="entry name" value="IQM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250">
        <property type="entry name" value="PTHR31250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="625"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="648" mass="66206" checksum="77C9317031E24524" modified="2018-12-05" version="1">MPRARSNAVSGSNAPFIGARPSGGAQRGPLSIGSQRQQQPALQMQEEIGNQATMDAMTAPASDGYVDFPPAAPSAGPDSAPAAPAASPSAAAPLPPGYVDYLPLGGSASAPAAPAASPSAAAPLPSGYADYLPLGGSASAPAAPAASPSAAAPLPSGYADYLPLGGSASAPAASPSAAAPLPPGYADYLPLGGSASAPAAPAASPSAAAPLPPGYVDYLPLGGSASAPAAPAASPSAAAPLPPGYVDYLPLGGGAASAPAAPAAPAPQASVAAAPQSPVQSAPAPAEGFKMKEMEASMPAFDSQLFPPHPHMHTALPSTTFYADDQELAPYARGFDAQGKMINADGSGPLSTIGAERPAALGAKGDRHIFTMDEGGSFHTADAIKENKTRSSEALAAGQSEMERFHHSSFHSGNDVAGAGELQIRDGQVEMVSDASGHYRPGSEQMMQTVQQLGRNNVSMERLGVEFIGKQRSQDENGAWKTEKNLQASAMEMLGYENHASVKDTERNMRAAHAKKDGVMQELLSKAASSPDGHSLKPSDIKPKPRPEEAASPMPSAPVASEAPTPQQSAPVEDHVYDSPDSESYIAYNNIEAEARENEAEQAPDNHTYDVVEENPYNNVYESPAQEVEAEEMPGSPVYDLIEEHTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMV7</accession>
    <name>A0A398CMV7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02579">
        <property type="protein sequence ID" value="RIE02579"/>
        <property type="gene ID" value="D3H35_18005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="515"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="731" mass="80289" checksum="5CE83D68DE3864CC" modified="2018-12-05" version="1">MTAYRNGQEHLHDELAWLNEALKSLLEAGGGQPLADPAFFSVRGLVVSKEELADPSADGTVFSAREDGASRWEEAVSRRQAAERAIALRAEAAMRAGVSLPLAQLCGRLRLTVLERRCVVLCLAAETSRSYEKWFSYLNDDATAKWPTPDLAVRLLCDRPDQATAVREMLAGSGPLRALLLEQEDTYGGGGASLSRPRLKSALKLDERTVSFLLATERIDARLAGIASGFEPEDALPPLPSKDAVRDRLQALAERNEGDSVPFVHLWGQAGGGKKLRMRYAAASRGQRLLVVRTEGVPSDSERVSIALHRVVREALLTGAALCVAEEHASSGAEVANLPEWKKALSAYAAYSRRPLLSWTSNVRRQPSELPLPERATWLAGEVAVPEANIRAAFWGAELSQAPEGHEWPEGLDRKLADKYRFTPGQIADAWQQAAAFAAGVGGVPTPEELDAASRGQFRHRLAQLADRIEPARSWADLVLQDEPLSLLQEACSRFRHRETVFERWGFGRKLPYGRGLSLLFAGPPGTGKTMSAEIVAAELGLELYRIDLSRIVSKYIGETEQRLSELFAEAEHSGAILFFDEGDALFGKRTEVKDAHDKYANLEAAYLLQRIEAYDGVSILATNLIQNLDEALIRRMSFIVKFPFPDATERARIFRAHLPPEAPLSEDLDLEFLASRLDVSGGYIKNIVLAGAFLAAAEDKPIGMSHLVRSARQELVKMGKILVKESFAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMX4</accession>
    <name>A0A398CMX4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LysE family translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_11090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03590">
        <property type="protein sequence ID" value="RIE03590"/>
        <property type="gene ID" value="D3H35_11090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="208" mass="21853" checksum="4953378CB691C954" modified="2018-12-05" version="1">MLAGFLGTSVLLTLMPGPDILFVVGLSAAGSKRDGVAVALGLCSGLLVHITAAALGISAVVYSLPWALHLVKAAGALYLLYLAWLCWKPSDGSGDGGNGAEGGEAVERSFGRLYRRGIWMNVLNPKVSLFFVAFLPSFVVSEGESVPLQMLTLGLVFLLQALVVFTLVAVLANRIGSRFLQSGGMRRWASRVEGALYASLAAWLLLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN10</accession>
    <name>A0A398CN10_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Guanylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_15665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02178">
        <property type="protein sequence ID" value="RIE02178"/>
        <property type="gene ID" value="D3H35_15665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="184" mass="21126" checksum="F79E4CDDF0C39F5E" modified="2018-12-05" version="1">MDSQKRMFVFTGTSGSGRKTIARKIGGEFGLTPVISCTTRPPRNPAKPDSDYHYISAEQFEEWENGGLFVQTSEIDRHKYGILNRELERALSGEADVSLILNREGASVVKRLFGDRVVRIFIYVDKQTVRERLESKGTSYEVVNAYLDHYPDEVTYRKSCEHVVENVELSRTLEQLRGIIRSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN82</accession>
    <name>A0A398CN82_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2087 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02248">
        <property type="protein sequence ID" value="RIE02248"/>
        <property type="gene ID" value="D3H35_16065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018656">
        <property type="entry name" value="DUF2087"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09860">
        <property type="entry name" value="DUF2087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="201" mass="22964" checksum="8A41F5CC40B507A7" modified="2018-12-05" version="1">MQLEKLVAYHKALADPTRIKLLVLLSGGELSGQSLAEKLCISPATVTHHASKLRAASLINERRDKNTIYFSLNDYFIRTSGAATANLIYKNTSTGGIPDMEVEPNQRLRDSVIRNFITADGKLKHIPAQLKKKLIVLEHLAAALERGRTYSEKEINAFIQTFHDDFATIRREFIMHQIMFRENDKYELNPPELWAKWRTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNB4</accession>
    <name>A0A398CNB4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01407">
        <property type="protein sequence ID" value="RIE01407"/>
        <property type="gene ID" value="D3H35_23855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="66" mass="7633" checksum="857B93566BFDBC0A" modified="2018-12-05" version="1">MLPNPTFDVLKRSHEQILCRRLFLLVKFGLRLVQRVWKTDIAGQGGASFACYAANANGFLRRYQIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNL9</accession>
    <name>A0A398CNL9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PLP-dependent aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_19670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02849">
        <property type="protein sequence ID" value="RIE02849"/>
        <property type="gene ID" value="D3H35_19670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="503" mass="55399" checksum="4FEBA23E3DF26476" modified="2018-12-05" version="1">MLPIDYSGQLARFGIKHVALYEAIREAIADGTLAPGERLPSTRTFAAEYGLSRGSVSLAYDMLASGGYLRAGIGQGTFVAGSPGTKRPDNNRCEDGDRAAPAAPRLSSWGKRIAAMYEEERLTERGANEAGSADIRVSFVPQGIGSRWFPWAEWRAVTAARWKKLGASGEDGSSDPAGSMGLRRSIADRLRRERGITCDPGDIVLTSGSMQAIALVSQILLEEGTNAVVENPGYSGIRRAVRMSGARCVEGNVDECGIVPEDWDADLLFVTPTRQFPTGAVLTYDRRLSLLSWASRRGAWIVEDDFDSDFRWGGRPVEPLKALDTEERVVYIGTFSRSMRREVRIGYAVVPKQLREPMLAAKKLYDPYPVGVAEQEALADWMADGGYDRYMKRLRRSYGRLESMLRQRLEADLPGLFRIAPSDAGLHLYAIWLRDSESYGEFKRECRLRGVAWKDGTGYDAHSGSSSTAGAPAALFGFSHLEEREIEEGISVMREAAETIREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNP8</accession>
    <name>A0A398CNP8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3 12">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">purM</name>
        <name evidence="15" type="ORF">D3H35_16675</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AIR synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3 12"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02348">
        <property type="protein sequence ID" value="RIE02348"/>
        <property type="gene ID" value="D3H35_16675"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="13">
        <location>
            <begin position="58"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="14">
        <location>
            <begin position="173"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE02348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="348" mass="37325" checksum="084F4AB95B24C40D" modified="2018-12-05" version="1">MSEAYKQAGVDIAAGNEAVERMKKHVKRTFRPEVLTGLGGFGGLFGLNKDKYEEPVLVSGTDGVGTKLKLAFQMDKHDTIGIDAVAMCVNDVIVTGAEPLFFLDYLACGKLVPEKIEAIVKGIADGCEQAGCALIGGETAEMPGMYQDGEYDIAGFTVGIVDKPKAIDGSTIKPGDAVIGLASSGIHSNGFSLVRRLLLEQQGYSLDQKLPELDGKTLGEVLIEPTRIYVKQILKLLESIQIKGMAHITGGGFIENIPRVLPEGVNVDIKSGSWPVHAIFDVMQRDGSITDRDMYTTFNMGVGMVLVVPAEQAEQALSIAKELGEKAYLIGQVTEGSKIVTFDGVEWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNS0</accession>
    <name>A0A398CNS0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00554">
        <property type="protein sequence ID" value="RIE00554"/>
        <property type="gene ID" value="D3H35_27840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="218" mass="23588" checksum="2D4F5453FFC53961" modified="2018-12-05" version="1">MDEALVKKLKLPHGGHIAIVQPPEGYLASLGLSPEETRLDVARVGEYDFVQLFAYGSGDVERLGPAAARAVKPGGLLWVCYPKGTSAIKADINRDRGWGPLAEAGFEGVALVSLDETWSSMRFRPASGKPRVTPAERKAAVAGEPSASEGVLDTPEDLLAELIKHPEQAALFEKLAPSHKKEYVRWIVEAKKAETRASRIGKAIEKLSQGLKRPSDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNS7</accession>
    <name>A0A398CNS7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4'-phosphopantetheinyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_16825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02378">
        <property type="protein sequence ID" value="RIE02378"/>
        <property type="gene ID" value="D3H35_16825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="106"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="238" mass="26756" checksum="F380790B2F68B336" modified="2018-12-05" version="1">MAQLFAVKISSFPIERLPGLLSLLPHEKAERLRKFIRREDLIRGLLGDLLVRRLASDKLKYPPEALRFGTNSYGKPYVSYPEKASAFHYNLSHSGEWVVCAIDDEPVGVDIEKIDSADIAIADRFFSPEEVGCLRMERDELSRQLLFYGIWTAKESYVKAIGSGLSKPLDSFSVVFSERLGGTGIIDGEQWHLRQYPLDPGYVLTSCAKSRMSAEAVDIVDLERLLDSFDLPIVRAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNZ5</accession>
    <name>A0A398CNZ5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ryanodine receptor Ryr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03009">
        <property type="protein sequence ID" value="RIE03009"/>
        <property type="gene ID" value="D3H35_20655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003032">
        <property type="entry name" value="Ryanodine_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02026">
        <property type="entry name" value="RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RyR" evidence="1">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="95" mass="10769" checksum="60AFFD84C1D0BCAD" modified="2018-12-05" version="1">MAYRPNPIDTSSIVLSEDVLELTEKLAENAHDEWALQRLSEGWTYGPERNDALKHHPGLVPYADLTEGEREYDRITAMKTLKALQALGYTIALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP18</accession>
    <name>A0A398CP18_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="13">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="13">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pheS</name>
        <name evidence="15" type="ORF">D3H35_09220</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="13"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04112">
        <property type="protein sequence ID" value="RIE04112"/>
        <property type="gene ID" value="D3H35_09220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="14">
        <location>
            <begin position="111"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE04112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="344" mass="38354" checksum="C15AA1395AFEF962" modified="2018-12-05" version="1">MKDRLEALRSEALQQLADVADAARLNDLRVHYLGKKGQLTEILRGMGALTAEERPIIGQVANDVRAAIEAVIAEKQEEYDRAEIARRLQAETIDVTLPGKAPGVGAVHPLTKVAQEIEDIFLGMGYTIAEGPEVETDFFNFEALNLPKNHPARDMQDSFYITDEILLRTHTSPVQIRTMKAMNGQTPVKVICPGKVYRRDDDDATHSFMFHQIEGLVVGPNIRMSDLKGTLLQFVQAMYGSQVQIRLRPSFFPFTEPSAEVDVTCTQCGGDGCRMCKHTGWIEILGCGMVHPKVLEHGGYDPKEVTGFAFGMGVERIALLKYDIDDIRHFYGNDVKFLGQFARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP75</accession>
    <name>A0A398CP75_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04182">
        <property type="protein sequence ID" value="RIE04182"/>
        <property type="gene ID" value="D3H35_06060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="100" mass="10470" checksum="A020F425A8935172" modified="2018-12-05" version="1">MDMQPMHATFENQDDAEEAVRKLSALRGDRFRLEKVAGKPAGVDSDASIEAAGSLGDPDSAFSSNETGGVPAFTLSANIPAEALERARTVIEQAGGSFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPP7</accession>
    <name>A0A398CPP7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_00960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05386">
        <property type="protein sequence ID" value="RIE05386"/>
        <property type="gene ID" value="D3H35_00960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="52"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE05386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="366" mass="40838" checksum="87F62E01954A26E9" modified="2018-12-05" version="1">MFHKETIALPFRIFTKGEFMNHTKSALDPIRPALVLGKLLVWARSYWTSYSLLLVIIIASAALPTGVAEGMRRLFNAVQFGSISGMLSAAAMLAAVFFIGMVLALLRAWSMQKLSIRSTLDLQREVLGRLIRLPLRTFGNWHTGDKINRLNGSAVAAQEGLNQRIPQLLEQVLSIIILLVYLSVLSWGLVAGALASSLLFPLLSNLMGKSIRKWQMTMNESQAIQDSRLQDQMQGADVVRSFGLRESFNARWREQVEVTRRSGIRVYMWLTASGLTIFAGSWIGQIYIFSVGAWFVMKGNMEIGVIAAFMIAYDRLFYPFAHLANMWAAIQDSLAHGARVFQMVDPTDAKPMTEGDAPLPDYGDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPQ8</accession>
    <name>A0A398CPQ8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III subunit delta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04170">
        <property type="protein sequence ID" value="RIE04170"/>
        <property type="gene ID" value="D3H35_05970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="1">
        <location>
            <begin position="19"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="343" mass="38610" checksum="B62B226E8A8038D9" modified="2018-12-05" version="1">MEASQAFRELREGTVRPVYVCHGTESYLMNEFVERLTEKLVEPEHRDMAIIRFDTGEMPIDVVLDEAETMPFLVERKLILVRDSVLFASGKESSRIEHRAERLLAYMAQPMETTVLVFLVPHEKPDERKKLVKTAKSSDSVIAFTSLPPEELQRWVMKRAERQNRTLEPAAAEELLKRVGTDMLSLAAETDKLCLHAGEGGRVTAGAVDELVPIATEQNVFRLTEELAALRTGKAISLYYDLLKQREEPIKLMALLVRQFRNMLYVKELGGQGYSPQQMAGQLGLHPYAVKITAEQARKFSVERLSKLLSELADLDYAMKTGQVEKTLGLELFLLRTGSAGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPY3</accession>
    <name>A0A398CPY3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04250">
        <property type="protein sequence ID" value="RIE04250"/>
        <property type="gene ID" value="D3H35_06435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="111" mass="12743" checksum="ED98BD7EEA6B05BF" modified="2018-12-05" version="1">MIVVINTIQVKPGYGDVMKERFRSPKSVHTFPGFVRMELLRTEGTEQYEEYQVCTTWESKDAFDGWAQSDSFKQAHARRQEDRAGSSEMVVGNKITIHEVLFSHLPALQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ32</accession>
    <name>A0A398CQ32_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_05515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04552">
        <property type="protein sequence ID" value="RIE04552"/>
        <property type="gene ID" value="D3H35_05515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="396"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="601" mass="66725" checksum="340DDC4BE2282CF5" modified="2018-12-05" version="1">MRRKLAKPGRLFYKLSIPMFILLLCVIGLFSAVSSYILIRAQNDHAYRMAEQSLTFVYRSVGYQLATMNNTAAFVLSNPSFEKLLDTGHERPYEAIGDFFELQSHLENLSLVSLLNEYGPAGRTKTTYVIAVALEPSSGLYEVATDEYYPATGLYKSDRLRQTEWYSELHDRGKQTAWWGEQAGVKPSVFVARSKTSFRDGHEIGTVLVGADMSAIQGVMAMAPIEKGYHLLLDEADRVIYSDKYPFLEDLSGSSIVRAMDGSRGSAKVSVNGERHIELYETLDNGWKVISFMPASHIGSDTLLISLVGVLIGILGVAVTGFLLRRIIVKVTVPVIRLVGAMQRPDVLEGKEPLPTPIGGIREVDELYRQFASMLVVNRELAVKAYRDEIAKKQLHLELLQSQINPHFLYNSLDLINCRAILAGDRDTSKLVRSLANVFRFGLNKGKTWIPLADEIRQATAYLDIQTMMLADLAYSIEVPPSLADAPVIHLIVQPLAENCIVHGFANRTERCRIRLSCREEDGKLILCVEDNGGGADAAELNRRLLEAEKDYADPSSPGLSGGYGTLNVHRRIRLHCGEGYGLRYVEVPEGTRAEAVLPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQF6</accession>
    <name>A0A398CQF6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_14885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02047">
        <property type="protein sequence ID" value="RIE02047"/>
        <property type="gene ID" value="D3H35_14885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="45"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="155"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="213" mass="25229" checksum="938BAF13D6DA3301" modified="2018-12-05" version="1">MFFIEKCRVRRYRRRLLIGEEGKTIDSAWITRVQDGDTEAFRIIVEHYRDPLLRLLLPIVGDAKEAEDVLQETFVRIFLSLREYRGEGFVTWISRIAVRQAIDWRRKKGRRRETPEADVELRAEMVGAAAGIGLAAAAESPDERLLERERVDRFADRLGRLPSRYRDVVQAYYVEEKSYQEIADREGIAAKTVESRLYRARRWMRDHWKEEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQH7</accession>
    <name>A0A398CQH7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NTP_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_20895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03048">
        <property type="protein sequence ID" value="RIE03048"/>
        <property type="gene ID" value="D3H35_20895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="2">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="290" mass="31370" checksum="302CBBCE2FBB9BB1" modified="2018-12-05" version="1">MRKSAVLLAGGAGRRMGGVNKAQLTLGAETFIERQIRIVSQWADEIVVVTNDEAFASSLTEAASDLAANSPPGPVVRTTPDLFVREGPLAGLHAGLSAASHRLVWLLGCDQPAPDPRAAAWLADRLASVNGGEQGRFAAELPNGPERNAAAVRHLAALPRIGEDFSRFTRFMTATLRPSRKSFFAKESAGCCRCWIGSSGSQSRNANSPSMELPQRSPTTSILPSNTNEYINRFTMYRMISRFSPMQTKGARDSHAIADHARRSREISKTYHSTGRSAANFARKSRTSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQI6</accession>
    <name>A0A398CQI6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03058">
        <property type="protein sequence ID" value="RIE03058"/>
        <property type="gene ID" value="D3H35_20965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="31"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="174" mass="19575" checksum="BBE0FF252500BFDA" modified="2018-12-05" version="1">MEQWIYPIGRFVKPATTSDDEREQRVRAVSTAPAALRAAVEGLTGQQLDTPYREGGWTARQVAHHTTDAAMTGYTRFKLALTEDNPTVKTFEENAWAALPDSIGLEPEVSLLLFESLQTRFDAVLRELPAESFSRPFLHPANGEMTIDQLLAYFAWHGHHHAAQIATLRNRMGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQJ2</accession>
    <name>A0A398CQJ2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_04925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04815">
        <property type="protein sequence ID" value="RIE04815"/>
        <property type="gene ID" value="D3H35_04925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005690">
        <property type="entry name" value="GerBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="475" mass="52170" checksum="F3D5FFD06259FAA5" modified="2018-12-05" version="1">MLKTGHSWFDDAIEGCSDVRLEHLAAEAGSIVIAFEEAMIDYRLLYETIVPKWLAEERKEDGRRKPPYQTSELHQETDADKKALLSILFSGAILLFADGRVFAAGLSQIPGRSPEESSTEISVKGPKDGLIEELSVNIALIRKRLRSVDLKVQRFAVGSVTQTPVALLYVASRAKPELIEEACRRIRSIKVDALEGAAIEGLLQDNPSSLFPELDYSGRPDYLFEALMKGRVVFLVEGTPQGFVAPINMFLLLKSPEDSSMPYYFVTFERIIRLVGLVCTLLLPGFWVALSAYNPDQIPFPLLATVIQSRNGLPLSTTMEMTLMLLMFELFREAGVRLPRAVGQTVAVVGGLIVGDAAIRAGMTSPTMLVVSAITAVTSFTLVNQTLIGAVTVLRFGVLLLSSVLGMFGFFIGLFSLILYVSTLNSFGHPYLSPVSPIRWKDVLPALIRLPIRSRRGAFSPKRPESGSSQSEGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQT7</accession>
    <name>A0A398CQT7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_15715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02187">
        <property type="protein sequence ID" value="RIE02187"/>
        <property type="gene ID" value="D3H35_15715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="8"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="342" mass="37268" checksum="B4D6D4DDA55370F7" modified="2018-12-05" version="1">MSKPILEVRDLKVSFKMHAGEVQAVRGVSFDLNKGETIAIVGESGCGKSVTAQTIMRLVPTPPSFIKSGAIVFDGKTDIVKLNEKQMEKVRGNEMGMIFQDPMTSLNPTMTIGAQITEGVIKHEKVSKSAAWKRAVELLSLVGMSNPEQRVHQFPHELSGGMRQRVMIALALACNPKLLIADEPTTALDVTIQAQIIDLLRDIQKKTDTSIILITHDLGVVAEIAQRVIVMYAGKVVEQGTLDEIFYESRHPYTWGLLKSVPRLDSDRNSELESIPGSPPDLYAPPVGCAFAARCPYAMKICKEQDPGHFHISDSHSAACWLNHEDAPKVGRPVGAGGHANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR38</accession>
    <name>A0A398CR38_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gamma-glutamylcyclotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03729">
        <property type="protein sequence ID" value="RIE03729"/>
        <property type="gene ID" value="D3H35_10075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GGACT" evidence="1">
        <location>
            <begin position="9"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="131" mass="14721" checksum="6499622B8276CFEC" modified="2018-12-05" version="1">MHTNGSQRLFIYGSLLPGLSNHGVIEPFWLACVPGSVRGRLVDVGEYPAVVQDDKHTVRGLWVDIRRAGLPVLDELEGFVGIEEANDYERVWMTDSADPALSGWVYVWADTRGYPWAGSECWVSVWARKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRM2</accession>
    <name>A0A398CRM2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_24770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01564">
        <property type="protein sequence ID" value="RIE01564"/>
        <property type="gene ID" value="D3H35_24770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="253" mass="26699" checksum="C0E3430D811BE0B0" modified="2018-12-05" version="1">MYPPFDLTGKVAMITGASKGIGFGLAKALAHAGAKVAVAARNREQLDHLVSEIRADGGDAVAFTLDVRDVKEIDSVIHQVKIHFGKIDILVNNAGLGDNHPAVDVTEEAWDNMMDVNLKGLFFCCQSAGKIMLAQGYGKIINMSSQASVVGIVDHAVYCASKGGVNQLTKVLALEWSAKGVNVNAVGPTFTYTPGNSERLDDPAYLEGVLARIPNRRLAEISDVAGAVIYLASPASDMVTGVTLMVDGGWTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRP2</accession>
    <name>A0A398CRP2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_01495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05222">
        <property type="protein sequence ID" value="RIE05222"/>
        <property type="gene ID" value="D3H35_01495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017694">
        <property type="entry name" value="Phosphonate_tfrase_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03308">
        <property type="entry name" value="phn_thr-fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="210" mass="23700" checksum="6CF8A99F6E5BE23E" modified="2018-12-05" version="1">MKSIHQTHAQTPLSAEPSIHPSSQIWNSHAGEWTSVGPHNKIIESRIGDYTYTMDDVTMNYAEVGKFTSIASHVCINPVDHPMDRVTQHHMTYRRASYGFDETDDERFFDWRRGNRVSIGHDVWIGHGAIVMKGVTIGTGAVVGSGAVVTKDVEPYAVVVGVAARQIKSRFPKEIVDSLLRIAWWDWPRDTLMERFGELDDTLAFVRKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRT9</accession>
    <name>A0A398CRT9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03929">
        <property type="protein sequence ID" value="RIE03929"/>
        <property type="gene ID" value="D3H35_08165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="183" mass="21531" checksum="3724FA7FB2EC43AF" modified="2018-12-05" version="1">MSIYCSIKLTEDTQFDFYSEYPIKNKLDEISVIFKEKPNEVCIFIDTIQEAVTTIYRGLSKCVTNQMTLNSTLDIGRVGEKWNVWTNDLSDEVGEDEEDVYQEYWIWSSRDFQTWVYQKDGKSYIELSPSYRWHYVEPIENEEVIPFEAFMKGYKPTVIKITSEQLTILLDSLSKIKHDLGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRY9</accession>
    <name>A0A398CRY9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Paeninodin family lasso peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05365">
        <property type="protein sequence ID" value="RIE05365"/>
        <property type="gene ID" value="D3H35_00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="45" mass="5119" checksum="F66498CF38F80EAD" modified="2018-12-05" version="1">MENCAKKEWQVPALETLNVSETMYGKGMTNIDFVTTEDMDIYSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS11</accession>
    <name>A0A398CS11_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03528">
        <property type="protein sequence ID" value="RIE03528"/>
        <property type="gene ID" value="D3H35_12345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="182" mass="20471" checksum="86C17599CE84F5CC" modified="2018-12-05" version="1">MGLVSDRLIDSQEADRACFESVIFTNVTFSRNAFSNAEFTDVIFEKCDFSNESFRECNIHRAEFRNCKLMGLDLSDSTLRYVLFQSCSGDYANFRYADMKQVKFEDCSLRHADFYSSTMLKVDLERSNLDGAQLSGTKLDGIDLSDCEFTVLGVEAEDLRGCIINEGQAAVFASLFGLIIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS52</accession>
    <name>A0A398CS52_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_15790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02201">
        <property type="protein sequence ID" value="RIE02201"/>
        <property type="gene ID" value="D3H35_15790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="19"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="317" mass="35154" checksum="33AF0EB5BD0D4BC4" modified="2018-12-05" version="1">MNPIRYEPLVPRTLLNAVKAPSMPFDWSINPYRGCQHGCSFCYARSTHSFLGESADDAFRSHIYWKKDASAILRSQLRRMEKGKSGLPSHVAIGTATDPYQQLEGREMLTRGCLETLAEFGVPVSITTRSPLVLRDLDVLRKLPGCSVNVSVHTLDPIVWRTFEPSTPSPKLRLDTVRRLNEAGIAANVFMAPILPYITDDDASTEAIIDGCARSGAQSVMPSFLRLSTPEVKAWFFSTLDRAYPRLTADYGALYWRSSSASDEYKLPVRERIRKQLADYGLSSFEKVPQPKAANTIHAAPPSACSAEAAPVQLTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS64</accession>
    <name>A0A398CS64_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PLP-dependent aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_13360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01784">
        <property type="protein sequence ID" value="RIE01784"/>
        <property type="gene ID" value="D3H35_13360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="473" mass="53888" checksum="F51BE43E2C8C6332" modified="2018-12-05" version="1">MLNLNLTAHSSQPQYMQLYTQIRDQIRSGGVPYGSRLPSVRSLRLQMNISKSTIETAYQILLTEGYAVSKPRSGLYVANPLGVKPYRPSKDSGSAPGEHPHSPPSPTSEPFSIDFRPSAIDEHSFPVRIWRKMLHDALDRSPDKICKYGDPQGEHSFRSVLAEYLRNSRGVVCTPEQIVIGTGIRYCIGVLSKLLTGIGPVAFEEPGYAPVREHLISNGFQIAPIPVVDQGISVEELDNSPAQAVYVTPSHQFPTGRVIPYPERELLLQWARKRNAYIIEDDYDGEFRYFVKPIPSLQGLDRDGRVIYVGTFSKAFTPALRMNYMVLPLELVDKMKNVQYLLDGPSRIDQWAMESFMEQGHWYRHIRRMRKIYGKRHHRFIETIRAHFGDRVQITGHNAGLHIQLTVKTRQPSEALVRLAAEEGVRVYDLPEMWMKPHRSEHPQIYLGFGGMDENGIDKGARLLRKAWEGIWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS93</accession>
    <name>A0A398CS93_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_02820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05080">
        <property type="protein sequence ID" value="RIE05080"/>
        <property type="gene ID" value="D3H35_02820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="170" mass="18207" checksum="85D756FEEC697B17" modified="2018-12-05" version="1">MEMGNLAIVNEPSVRKRRETYGVNSFQGYIEETLSRLRIPFQAFESLQAALEWKPDILIPALCEENADNGQKLQDYVEAGGTVVSYAGLRGLAHKLGYCEERPLGPGYAVLPEALGPIRFLSATGWSKIGVQDAAKTGSLHACSPTGAEAGPALLSIPWAGERSSAGRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS96</accession>
    <name>A0A398CS96_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RluA family pseudouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_16080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02251">
        <property type="protein sequence ID" value="RIE02251"/>
        <property type="gene ID" value="D3H35_16080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="4">
        <location>
            <begin position="217"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="423" mass="46373" checksum="7A49676CBD97B413" modified="2018-12-05" version="1">MNDKPARRAPARHNAKPKPIIPAGKNAKHAALALEREKKQAEAEAKAKQGSRNSRKTAKAKERPKAGTAEAKGQRGIKPAAPEGDNNPTKKDAYATERKKVLAEVAALQKAKQPVGRSKSKTSAKTRLTAKQAAVPPRSFEVQEPSELLAFLISQLKNEGRNSIKSILARGQVSVDGQALTAYNYPLKPGQTVSVSRARAKEATRFAGLSILHEDDDVIVINKDAGLLSIATEQEKELTAYRQLTEHVRAGDPSRRIFVLHRLDRDTSGVMMFAKSEQVQKSMQDAWKDVVKERTYVALVEGTVTASEGTISSWLKENAAMKVYSSPEPNDGQHAVTHYKVVQAGRQYSLLQVNLETGRKNQIRVHLQDIGHPIAGDKKYGAKTKPIGRLGLHASVLSFEHPRTGELMRFDTGVPTAFRKPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSD1</accession>
    <name>A0A398CSD1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_13775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01854">
        <property type="protein sequence ID" value="RIE01854"/>
        <property type="gene ID" value="D3H35_13775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19157">
        <property type="entry name" value="AKR_AKR5G1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044500">
        <property type="entry name" value="AKR5G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="31"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="280" mass="31657" checksum="6E449B2C4FDF935F" modified="2018-12-05" version="1">MPNHLQDTTLLNNGVKMPWFGLGVFKVEEGQEVVASVKAAIRNGYRSIDTAAVYRNEDGVGQGIREALLETGLSREELFITTKVWNSDQGYESTLRAFEESLRKLQLEYIDLYLIHWPVKGKYKETWKALEMLYRGGKVKAIGVSNFHVHHLEDLLQDAEIVPAVNQVEYHPLLNQKELLVFSKSKGIQLEAWSPLAQGKILDNPVLQEIAAKHGKSVAQVVLRWDLQNGVVTIPKSINEKRIVENADVFGFELSDEDMASIDSLNRNERVGPDPDNFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSK6</accession>
    <name>A0A398CSK6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SIS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03728">
        <property type="protein sequence ID" value="RIE03728"/>
        <property type="gene ID" value="D3H35_10565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="94" mass="10037" checksum="F69F09B3A3125845" modified="2018-12-05" version="1">MFLEQLINFYNPGDVVVAISASGSSPNIIKAVEWAKEQGSLVIGLTGPKGAKLKSHSDVCVMAPTAPYELIEDFHVICMHTMVTALKEAYGGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSL4</accession>
    <name>A0A398CSL4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000031">
        <property type="protein sequence ID" value="RIE03738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03738">
        <property type="protein sequence ID" value="RIE03738"/>
        <property type="gene ID" value="D3H35_10025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="152" mass="17548" checksum="3F0AB85122E0915B" modified="2018-12-05" version="1">MLVPFSYRFDPDEFRRMLKANPKFVKQDDRSDLKKHVLQGKVILSLEGTVYSFDAIRKLITKPDTAQVETALQGPYSALAEDLDINLYLIRSSYNDSSLAIEYRRLGTYPTPGFRSSTTKSWSTNPFERSSIAACPRRISSWFRQRANWAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSV8</accession>
    <name>A0A398CSV8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fumarate hydratase class I</fullName>
            <ecNumber evidence="10">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">D3H35_19975</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible hydration of fumarate to (S)-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the class-I fumarase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="10"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02897">
        <property type="protein sequence ID" value="RIE02897"/>
        <property type="gene ID" value="D3H35_19975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011167">
        <property type="entry name" value="Fe_dep_fumarate_hydratase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001394">
        <property type="entry name" value="Fe_dep_fumar_hy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="11">
        <location>
            <begin position="6"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Fumerase_C" evidence="12">
        <location>
            <begin position="307"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE02897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="508" mass="55005" checksum="6F36206E1B72C6F7" modified="2018-12-05" version="1">MSTFEESMYKLIVETSTNLPADVRRAIAAAREEEDRATRAGLSLTTIAQNIEMAECNVSPICQDTGMPTFIVHTPVGANQIVMKQEIKNAVARATKDGKLRTNSVDSLTGANTGDNLGAGTPVIHFEQWEKDVVEAKLILKGGGCENKNIQYSLPCELEGLGKAGRDLDGIRKCVMHAVYQAQGQGCSAGFIGVGIGGDRTTGYELAKHQLFRSADDVNPIPELRQLEEYVMDKANQLGIGTMGFGGNVTLLGCKVGVNNRLPASFFVSVAYNCWAFRRQGVVLDGTTHEIKEWSYEGGSSVPMKTEAAEDTSAPRREIVLKAPLSEEDVRQLKVGDVVILNGEMHTGRDALHKYLMDHDSPVDLNGGVIYHCGPVMLKDDDGWHVKAAGPTTSIREEPYQGDIIQKFGIRAVIGKGGMGPKTLAALQEHGGVYLNAVGGAAQYYAECIKGVKSVDFMEFGIPEAMWHLDVEGFAAIVTMDSHGNSLHAEVEQSSKQKLAQFKDPVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT96</accession>
    <name>A0A398CT96_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aegerolysin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05380">
        <property type="protein sequence ID" value="RIE05380"/>
        <property type="gene ID" value="D3H35_00925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019836">
        <property type="term" value="P:hemolysis by symbiont of host erythrocytes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009413">
        <property type="entry name" value="Aegerolysin-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06355">
        <property type="entry name" value="Aegerolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007951">
        <property type="entry name" value="PIRSF007951"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="152" mass="17439" checksum="9CF7ED6D31FE01E6" modified="2018-12-05" version="1">MSYSMWVEVSIDTYNSDVSIQNVELQWGKLYQFGNKDIEISPSSLNGTVIKEGTSFWFCACGRGWSPSGTQGSFQLFDPDNKLIGTYNWDCPIGEHYNQSSWVRENDTNFQFDFHSGNCNYYGQKNKSGTQIGRVTLRLWDASKPPYVKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTE7</accession>
    <name>A0A398CTE7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_15985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
            <topology evidence="1">Peptidoglycan-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02234">
        <property type="protein sequence ID" value="RIE02234"/>
        <property type="gene ID" value="D3H35_15985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06920">
        <property type="entry name" value="NEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1850">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006635">
        <property type="entry name" value="NEAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037250">
        <property type="entry name" value="NEAT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05031">
        <property type="entry name" value="NEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00725">
        <property type="entry name" value="NEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158911">
        <property type="entry name" value="SSF158911"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50978">
        <property type="entry name" value="NEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017298685" evidence="3">
        <location>
            <begin position="35"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="domain" description="NEAT" evidence="4">
        <location>
            <begin position="41"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="NEAT" evidence="4">
        <location>
            <begin position="582"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="NEAT" evidence="4">
        <location>
            <begin position="782"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="NEAT" evidence="4">
        <location>
            <begin position="923"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="5">
        <location>
            <begin position="1086"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="5">
        <location>
            <begin position="1150"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="5">
        <location>
            <begin position="1209"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1035"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1035"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1274" mass="136255" checksum="8C52ABCBF6464EF8" modified="2018-12-05" version="1">MKLKTRLKTTIVFLLSFSLILSYLYAGPIASASAAAGNALVQNGAYQLDFNILKDGEVSVSTANMYMKINGTKGTLRVNDGVITFEHEIETENLNKFEYLGYRPDGAAKPPISGSSAPDTTAYVNATVSAGPTADKKIIRYAITDITKKQDILMHINITEIGYNHWYHAQIGIDTGPLNLPGSGGEDPGTSSGEGSNSGSVTLEKLQTLLAKAQEVYEGSAEGAAYGQYPAGSRALLETAIFAAKVELNATTEGDQAAYATIHNKLEQHLKGFQALQKVADKTALRALLPAMSKFISKALVNGQTNGGPGDVKSATVAGEYFHSDIKSLQRLLTNGEKYLEDPAATQTQVDNTVTGIRGQYEWTLQHRYVEFEPFELYVLDTPNATNEESAKVGLLSRAVTTISQASYTVNSGEVLGNIRLNQRPDDNKVMFFIPFGNGVYFSPDMYEAILPAAVTRYPNTAIGDTVYQSALKSFDDNLDTVWSGLGHITFKLNGVKQSLYLSFNRLIHQKLKQSLVDAVRYHDKAPKLSGADAADYDAAKADLSDAIAATEPVAANLNATRPDILNAAADLKAAVDAFKAVAQFEYDLYYSTLHATHSAFSEVDSYLAKPAKILPRSDGTYEVTLTVKGSSVIRELKVAKDGVYSDVTVLSENTADNSRVVRFVAADLTQQTLAKVRVVTSHQGASYDNTYDIRFHFNDVDNTALQGEIAAANGKLRAAVVGTQVGQYPLTAKTALSDAVAAAGEVAVNGANTEALTASALTALQQAVQSFDASVVTANDLPDGEYTIGFTVLKKDQEEVSTLNGYAVSPARLRIAGGVKTISFTLKQSAEIPSLKVNGQAVTVESTNATANTRVVSFPVTDLTVDTVGWTKFNWAAQSIYSEYDIRFRFDGASAAPYVSGPDPAGPVVPGVPGGGSGTGTLQDGNYFLPFRILKNGTDSTSIANDYVISPALLKVAGGSKTVSFTVLRSFEVNQITMNGSSGSIVSRDTANNTRVVSYPLTTLSGKQSGTVRIDWNEFNYHHSYDIQFQFDEGSMTSAGGNPTVPGGNGNISSPSLENPGTDEEKPPTETEQPKTEESSNEEQAPKANFSDTGSHWAIREINRAVQLGIVSGFKDGSFRPNQNITRGELITIVSQALKLEGDVSESDFRDLEQIPAWARKHAVLASKLGLISGYEDGTFRAGKSITRVELAIIIAKAAGLELKDDARLTFADAGNIPEWARKSIAAAVEAGLIKGKGNNRFDPNAPATRAEAVTLVLGLLDLDAKAAKKSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTI8</accession>
    <name>A0A398CTI8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_16235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02274">
        <property type="protein sequence ID" value="RIE02274"/>
        <property type="gene ID" value="D3H35_16235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="5">
        <location>
            <begin position="153"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="223" mass="24785" checksum="0AC870202A084345" modified="2018-12-05" version="1">MIRVLVADDQTLLREGLQTIINLEDDMRIVGLAGNGQEAADMAADVKPDLILMDIKMPVMNGIDSMRSIKRELPGILVIMLTTFIEDELIVDALAGGADGFLLKDMAGDHIVQTIREAFNGPLLLPPRISAQLTARLLYSPPRSQEPFHEKALKQNGLVFKDQERKMILLMIKGHTNKQIAAALHMSEGTVRNYISVIYDKIGTNDRSQAILSLKEFLLNHET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTL9</accession>
    <name>A0A398CTL9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="8">Glu-ADT subunit A</shortName>
            <ecNumber evidence="8">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">gatA</name>
        <name evidence="10" type="ORF">D3H35_18455</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02661">
        <property type="protein sequence ID" value="RIE02661"/>
        <property type="gene ID" value="D3H35_18455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="8">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE02661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="486" mass="51969" checksum="BFAB86AA3BD34AF3" modified="2018-12-05" version="1">MSLFDSRISDVHNRLNNKELSVSELVEASLARISATDSALGAFLTLDEEGARAQAKKLDAALASGEERGLLFGLPAGIKDNIVTEGLRTTCASQFLDNFTPIYDAEVIHKLRSAQSVTVGKLNMDEFAMGGSNENSSYGPVRNPWDTTRVPGGSSGGSAAAVAAGQVYFALGSDTGGSIRQPAAYCGVVGLKPTYGLVSRFGLVAFASSLDQIGPITKNVEDSAYVLQAIAGHDAKDSTSANVSIPDYVSSLTGDVKGLRIGVPKEYIGQGIDPQVKERVLEALKVFESMGAVWEEISLPHTEYAVATYYLLASSEASSNLARFDGVRYGVRADNPANLMDLYRRSRSEGFGSEVKRRIMLGTYALSSGYYDAYYKKAQQVRTLIKRDFDQAFEKFDLIIGPTAPTPAFKLGEQVDDPLTMYLNDIVTIPVSLAGVPAVSVPCGLADGLPVGLQIIGKPFDEATVLRAAHAYEGQTEHHKSRPALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU63</accession>
    <name>A0A398CU63_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DeoR/GlpR transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_17520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02494">
        <property type="protein sequence ID" value="RIE02494"/>
        <property type="gene ID" value="D3H35_17520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="252" mass="27953" checksum="1DEF80470FD34DA0" modified="2018-12-05" version="1">MLAAARHQFIMERLQENGTVKVVELSDRFGVTPKTVREDLEKLEDDGLLRRIHGGAVAIQGSDTILPLLQIPNTKFPLEKEAIAAHALRYIQAEDVIALDAGSTTLEIARRLPNEPLTVLTNDLMIVRELVGKEQIRLVVPGGYRQHNVLIGNDALEWVTRLNVQKVFLSAAGIHEKYGLSVFTGELIELKKAFMTGAKEVYAVADHSKFDRATLLTFASLQDVDLIITDAGLDDETVRRYEGSSVRIEKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUS1</accession>
    <name>A0A398CUS1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Iron-sulfur cluster assembly accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_20855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03041">
        <property type="protein sequence ID" value="RIE03041"/>
        <property type="gene ID" value="D3H35_20855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="102" mass="11391" checksum="50E721C445BEFF4D" modified="2018-12-05" version="1">MKCKITRNAATALRRELDKPENADLMVRVVIAHKHGNHAHYGLELDKPTDEDEVVSTDKGIDVLLPKGEDQDLLDGVKIDYFYLPQEGFAITNPSKGNHGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV15</accession>
    <name>A0A398CV15_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_19770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02864">
        <property type="protein sequence ID" value="RIE02864"/>
        <property type="gene ID" value="D3H35_19770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="113" mass="11926" checksum="00106AB9C219B6BE" modified="2018-12-05" version="1">MKSKGKSKSTGKGKSKGKSKGKGKARTGARGKGRARASGKGGLRRRKGSGGLRSRRSLGRRRVRDRGGRRRVGGRGGGGGDSAGFNHSYNEGYNHGFAKGLEDGHQIAYEQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV55</accession>
    <name>A0A398CV55_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_02025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05169">
        <property type="protein sequence ID" value="RIE05169"/>
        <property type="gene ID" value="D3H35_02025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="239" mass="25844" checksum="0EC3B6E2237F76C3" modified="2018-12-05" version="1">MISASELYLICSLARELRDGEAIAVGNHSPIPAAAALLAKELHAPNASVYILGQPDWPFEGTKEFFDWMQRGGADVFFLSGAQIDRYGNINLQAIGDYRTPKVRLPGGAGAAVVYSVCRRILLFKTEHSVKGFPDELDFRTAASRSGPGVFRRGSLAGVFTPLGTLRPAGTDGALKLSSVAQGVSPETVRANTGFELQAEAEVSETASPTNEERRVLREVVRERLRLIYPEYAASLTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVG0</accession>
    <name>A0A398CVG0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000026">
        <property type="protein sequence ID" value="RIE04508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04508">
        <property type="protein sequence ID" value="RIE04508"/>
        <property type="gene ID" value="D3H35_05750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="122" mass="13914" checksum="3413E10E6B36943C" modified="2018-12-05" version="1">MQNYRGLLFGVPSCLRQSQLLRWAIVIPATFAGIALTPLAYLVSDRVFSFELFGDDWLLNRSVYEFNARELFVHHRWNRPCSSAPYSLSDSSARRMYAAWIRWIAGEEKAIDVSEPHGSAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVL0</accession>
    <name>A0A398CVL0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_20945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03054">
        <property type="protein sequence ID" value="RIE03054"/>
        <property type="gene ID" value="D3H35_20945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="184" mass="19944" checksum="B25F1C1C508FC0EF" modified="2018-12-05" version="1">MRIRLTPERVLEAAADIANNEGLDKVTLAAVAAALGIKTPSLYNHVAGLEDLRMKLAEIGARKLRERLTEAAIGRSGDSALIAVAKAYAAFAGKEPGMYEALNRLPEAPSALFQTESDLILQLLVRLMEHYELNATTTVHAVRGLRSLIHGFASLDALGGFRMSENKDDSLIWAVSTYLKGLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWL4</accession>
    <name>A0A398CWL4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04958">
        <property type="protein sequence ID" value="RIE04958"/>
        <property type="gene ID" value="D3H35_03205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="79"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="218" mass="24383" checksum="0955647C4683E993" modified="2018-12-05" version="1">MPGKKMTIEFSYNAARIDRGMVARIRGHLQEVVAQLVETPHVHIDQLEIVTEEEKRQLLYEFNDTKASYPADQTIHGLFEEQVKKTPDHTAVVLESESLTYAELNGRANQLARVLRGKGVGADRIVGILAERSLEMIVGILGILKAGGAYLPIDPDYPAERIGYMLEDSGADILLTQKRLEAQTMGFAGEVLHVDDERLYALDDTILSIRAVPKIWRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXG8</accession>
    <name>A0A398CXG8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_07755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04467">
        <property type="protein sequence ID" value="RIE04467"/>
        <property type="gene ID" value="D3H35_07755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="60"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="445" mass="49088" checksum="DC90ED2984F788F8" modified="2018-12-05" version="1">MKSSLLITGATVLTVNSSDEVIENGAVLIEGSRIADIGPTDILEARYPNVEKLDAAGHAVLPGLVNLHLHSGLIRGTAEDLPVFEWLAKHVDPKHRALTEEIAEAAAKLCYTEALLSGTTCVMDMYRYMHRCADAAERLGIRATLAPYVVDKPGMDYFETLDKNVRLVEERHNTADGRIQVWFALEHLTYCTEDAYRRAAALADKYDTGIHTHGEESWEMARKLKQETGLWPVELFFDRGILGPRTVLAHCVWLEDPEIDLLVKTGTSVAHCPVSNLKLASGIAPVHELLQKGVTVGIGTDGVKENNNLDMLEELKFVPLLQKARLLDASVVTAERALRMATIDGAKALGRDKEIGSLEIGKQADLIVVDYRKPHLTPFLSGKYNNIVSNLVYSASGADVRHTFIAGRSIVRDRVLLTDNSEAIRLQAQEAAEKLFVLREPYIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXM6</accession>
    <name>A0A398CXM6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_08465</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03981">
        <property type="protein sequence ID" value="RIE03981"/>
        <property type="gene ID" value="D3H35_08465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016220">
        <property type="entry name" value="Me-P-triester_DNA_alkyl-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000408">
        <property type="entry name" value="Alkyltransferas_AdaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="SSF57884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="9">
        <location>
            <begin position="85"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="187" mass="21259" checksum="C9319889FACFB457" modified="2018-12-05" version="1">MTDSESASDEQWQAIVGNDASYDGRFFYAVKTTGIFCRPSCKSRPPKRENIQLFHSADEALSARFRPCKRCKPTGQRLPDAEWVALIVEYIDRYYMETLTLDKLAELSHGSPYHLHRTFKRVMGTTPVAYIQQLRIDKAKEELLASNRPIADVGASVGMPSPPYFITLFKKWTGVTPASYRQSNTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXQ3</accession>
    <name>A0A398CXQ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_08635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04011">
        <property type="protein sequence ID" value="RIE04011"/>
        <property type="gene ID" value="D3H35_08635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="336" mass="36319" checksum="9AF5581F28F5706E" modified="2018-12-05" version="1">MALKFGILDQSIVFPGQTPAEALGNTVKLAQLAESLGFERFWVSEHHDSPQMAGSSPEVLISHLLARTNTIRIGSGGVMIQHYSPYKVAENFNLLASLAPGRVDLGIGRAPGGLPRSTKALQKGLAESPSLAEKLDELQLFLHGEAGEDHPLPGLQANPLPVLPADVYVLGTSVSSAELAAERGLPYAFALFINNDPDTALQAFETYRSKFNRERGTEPKSILGLSVIAADTEEEAAALAGAFKSVRVTLASGKTVNVGSLEQAEEFARQAGETFTAEEREADITRGTKETVRKRLLELAERYGAEELIFTTIVPDFDKRIRSFTLLKEAFEELAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY49</accession>
    <name>A0A398CY49_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04151">
        <property type="protein sequence ID" value="RIE04151"/>
        <property type="gene ID" value="D3H35_05860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="97" mass="10426" checksum="738CB43CB559F8DF" modified="2018-12-05" version="1">MSDAEGTHRLWRPKRGRLSRGTRSEQNRSVFAGAANERDQIIGHARVEMYGGRQPLNLGDVLDGGDGLNVVAGAAGPGLHDQPFFGCDVGIAKLDFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZK7</accession>
    <name>A0A398CZK7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_03885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04641">
        <property type="protein sequence ID" value="RIE04641"/>
        <property type="gene ID" value="D3H35_03885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="328" mass="35551" checksum="858151A0D8911BB3" modified="2018-12-05" version="1">MNNRLMQFSFKYGALIFIGLVLLFFSLYNEYFFTYNNLTDILRSISIVTFVAIGVTISLTVDGFDLSVGSTVSLAAVVSATMMVWFEMPLVVVIVVPILFGALVGLLNAFLIVKVRIPDLLATLAVMYIVSGVHKTYTKGYSIYSNMNMQDGTKAPGIMTPEFLWIGQGKLLGVPFPVILMLVAVIGAHLFFKYTRWGRQMIMTGGNEEAARLSGLRVKRVRTLAYVASGVFASIGGILFAARVGNGQVDAGAPLLMDAVAAVFVGFSVFGAGRPNIIGTFFGAILIGVLVNGMTMLNVEYFKTDIVKGVVLVLALAVTFIHKDRHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D004</accession>
    <name>A0A398D004_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04791">
        <property type="protein sequence ID" value="RIE04791"/>
        <property type="gene ID" value="D3H35_04780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="163" mass="18724" checksum="C9EA49AF04599C1A" modified="2018-12-05" version="1">MAGIPLSNIRLVSEELLASRLEQVKLVREDENECYRLVKDSDTGEHYLHFASRHLNLSGGLSEEHYHHLMPLDHDDVISYALGAEVPSYPDHWERPFLRNGPHGGYVWYDPGGSTVDESAYEEATAALREKLLNMKRDGKTSEEDIKKLFEDAERLFPENRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D0K1</accession>
    <name>A0A398D0K1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">5-methylthioadenosine/S-adenosylhomocysteine deaminase</fullName>
            <shortName evidence="2">MTA/SAH deaminase</shortName>
            <ecNumber evidence="2">3.5.4.28</ecNumber>
            <ecNumber evidence="2">3.5.4.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mtaD</name>
        <name evidence="4" type="ORF">D3H35_04145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + H2O + S-adenosyl-L-homocysteine = NH4(+) + S-inosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:20716"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57985"/>
            <dbReference type="EC" id="3.5.4.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + H2O + S-methyl-5'-thioadenosine = NH4(+) + S-methyl-5'-thioinosine</text>
            <dbReference type="Rhea" id="RHEA:25025"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:48595"/>
            <dbReference type="EC" id="3.5.4.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.28" evidence="2"/>
    <dbReference type="EC" id="3.5.4.31" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04684">
        <property type="protein sequence ID" value="RIE04684"/>
        <property type="gene ID" value="D3H35_04145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090614">
        <property type="term" value="F:5'-methylthioadenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050270">
        <property type="term" value="F:S-adenosylhomocysteine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01281">
        <property type="entry name" value="MTA_SAH_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023512">
        <property type="entry name" value="Deaminase_MtaD/DadD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="60"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="434" mass="47339" checksum="DCF8063BCCA3C18D" modified="2018-12-05" version="1">MRRLLIEGGTFVTMDDSRPIMKGWMAVEGTQIAAMGEGEAPESEVRAAAETFKGEGFLFLPGLVNSHGHAAMSLLRGLADDLVLQDWLQNHMWPMEARFTSDDVYWGTSLAAAEMIRTGTTTFVDMYDHMNRVGEVVDSSGMRGVLTRGAIGLCPEDVQREKLRDAVTFAKEWNGAANGRITTMMCPHAPYTCPPGFIEKFVEAAHELNLPMHTHMSETAAEVEQNVRDYGVRPVEHLDKLGLFSRPALVAHAVHLTDEEIALLAERGVAVSHNPVSNLKLASGVARVPELLKAGVTVSLGTDSVASNNNLDLFEEIRMAALLHKGVSGDPTVVPATEALRMGTSQGAKSVFLDGVTGVLKPGLKADFIAMSTANTRFVPRTDYVSHLVYSASGMDVTHVWVDGKQLLRNGELLTLDEERIRAEAQRCFERLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1B6</accession>
    <name>A0A398D1B6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05291">
        <property type="protein sequence ID" value="RIE05291"/>
        <property type="gene ID" value="D3H35_01770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="79" mass="9089" checksum="58C724F03387D0EB" modified="2018-12-05" version="1">MPALLGIWAAAAAIVMIDLPYIRKNRLVGELWIFTLLLLLGLWLATAKALRWYLPNPMDWIIAFYKPFSDLLSRFGLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D2V1</accession>
    <name>A0A398D2V1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_00565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000006">
        <property type="protein sequence ID" value="RIE05414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05414">
        <property type="protein sequence ID" value="RIE05414"/>
        <property type="gene ID" value="D3H35_00565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="80" mass="9047" checksum="D21CC8D7C8C03F5E" modified="2018-12-05" version="1">MFDKQSKAVFAYSSEIVTALTRLIEQGQAAGELLREIRGYRLVVLLIRQGLGMINHDADDNLVREFVDRGCRIIGLLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBS2</accession>
    <name>A0A398CBS2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000051">
        <property type="protein sequence ID" value="RIE00606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00606">
        <property type="protein sequence ID" value="RIE00606"/>
        <property type="gene ID" value="D3H35_27490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="259" mass="29514" checksum="330C079728B8C116" modified="2018-12-05" version="1">MYGDNQSAFSVQLTKEGVIALREALQGEMSPIGIIYSLDYLALRPAYSVRLSIDWERVQNHLDETFGSDSIFYQSQITEAVDKLIDNRVIVIEDDLFVVEGEDEGLTARHEQAVDEVRSMITDAFFTPSLNPIEPEKEDTWDKIEHLAKTSSALAVTGGWGSLVSFSYRQIDYTRIDRKRLNVNFSERTAVKKSIYPQGHLSGLFKSLREPGIDLSRFVLSVDLIDPWFELRKIQVISRADYQEDDIASIHVTLEYGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CC24</accession>
    <name>A0A398CC24_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000057">
        <property type="protein sequence ID" value="RIE00330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00330">
        <property type="protein sequence ID" value="RIE00330"/>
        <property type="gene ID" value="D3H35_29100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="233" mass="25609" checksum="6C14624617343DD2" modified="2018-12-05" version="1">MAAGSLPVVHPLRLTHTEFIDKLKTGDEKFTGEIGMKAANLLSTLGKGGYFQKASAAWIIRKLELFPGRQCRHPLQRSWELAQFKDKYDSGEIGYFFIPEVAGAENNGPNTSITAGLAYAFNKETFDAETKRFFKFVVEHYNQAAFDVGGYLSPMNGDLPSNVFKLAKDFSLDLEAVAKGGVSWDDKLDPASNEVVGSTANELALGLITPEEFAEKVDKAIGRNAPSFFKDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCG8</accession>
    <name>A0A398CCG8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_28855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00423">
        <property type="protein sequence ID" value="RIE00423"/>
        <property type="gene ID" value="D3H35_28855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE00423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="226" mass="25208" checksum="76FB7A9F7E833FBB" modified="2018-12-05" version="1">MEILKIINLCKTYGYTEAQVKALNHVNLSVKQGEFVAIVGASGSGKSSLLHLIGGVDRPTSGQVIIDGVDIYSKNEKELALFRRRKIGFIFQSYNLIPVLTTEENIKLPMLLERKTDEGYVDELLGILGLMDRRHHLPSELSGGQQQRAAIGRALINKPSIILADEPTGNLDSKHSKEIVDLLTFSVKKYNQTLIMITHDLNIAQRADRVVYIQDGFLKQNEVSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCS5</accession>
    <name>A0A398CCS5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_29720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00215">
        <property type="protein sequence ID" value="RIE00215"/>
        <property type="gene ID" value="D3H35_29720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="144" mass="15949" checksum="C13F0E716DDC191F" modified="2018-12-05" version="1">MKVRLNPVVTLDNGLTFTDWNGRFDVSDPEVLQVQSNGLVVPGQTGRTHVTYRGFETSAGKDIAVIPSLSDLVRVTFRIQVPTDTPAKDALYVGRLAIPRLSERLFGGAFQLPRDTAIRFKIATDNGLRERKKMEGPFRIGFCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCV2</accession>
    <name>A0A398CCV2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="10">APRT</shortName>
            <ecNumber evidence="5 10">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">apt</name>
        <name evidence="12" type="ORF">D3H35_27755</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="5 10"/>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00540">
        <property type="protein sequence ID" value="RIE00540"/>
        <property type="gene ID" value="D3H35_27755"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="11">
        <location>
            <begin position="29"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE00540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="170" mass="18199" checksum="219742633FFB452F" modified="2018-12-05" version="1">MDFKEYIRVIPDYPQPGIRFKDITTLLKDGPAYRAAIEALKEKVAGLEIDLVAGPEARGFVVGAPLAIALGVGFVPIRKSGKLPSETIEASYDLEYGKDKLAIHTDSIKPGQKVLIADDLLATGGTIATTVNLIRQLGGEIVGAAFLIELGYLDGRDKIQGIEVSSLVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEA7</accession>
    <name>A0A398CEA7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-oxalocrotonate tautomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_26650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-oxalocrotonate tautomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00775">
        <property type="protein sequence ID" value="RIE00775"/>
        <property type="gene ID" value="D3H35_26650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004370">
        <property type="entry name" value="4-oxalocrotonate_tautomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01361">
        <property type="entry name" value="Tautomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="SSF55331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="79" mass="8793" checksum="419EA0A2232C2CFE" modified="2018-12-05" version="1">MLEMPIIQVDCWEGFTEDQKKAWAQELTAVTVNRFSIPADKVLVILRESPLANWTQGGVVANDPDFLDKSRSATLQSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEL1</accession>
    <name>A0A398CEL1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09400</name>
        <name evidence="1" type="ORF">D3H35_25860</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000043">
        <property type="protein sequence ID" value="RIE00885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00885">
        <property type="protein sequence ID" value="RIE00885"/>
        <property type="gene ID" value="D3H35_25860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03761">
        <property type="protein sequence ID" value="RIE03761"/>
        <property type="gene ID" value="D3H35_09400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="233" mass="26748" checksum="B6974EFAB3E80E4F" modified="2018-12-05" version="1">MSRRLIELPSTLLRIEGFRSSILNNERDLRLYLPPGYSENPDSRYPVLYAHDGQNLFDKGAHETDPLNPFAVARSWNLHLTADRLIAEGLMEEVIIVGIFNMGGERSGEYMHGLEGIEHERDRDQAVPRGELYERFLVEELKPFIDSVFRTKRDAENTGLIGSSRGGQITYHIGFSRPDIFGKLGILSPYFYYVNPLTLIEYRMYVSFPSRLPLSKIWIDLGGAKAFWSWKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF19</accession>
    <name>A0A398CF19_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Enolase</fullName>
            <ecNumber evidence="10">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">eno</name>
        <name evidence="15" type="ORF">D3H35_21355</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Secreted</location>
        </subcellularLocation>
        <text evidence="10">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="10"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01005">
        <property type="protein sequence ID" value="RIE01005"/>
        <property type="gene ID" value="D3H35_21355"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 10 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="14">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="13">
        <location>
            <begin position="139"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10 12">
        <location>
            <begin position="364"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 11">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 11">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="10">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE01005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="430" mass="45810" checksum="1F1B2F2454B93905" modified="2018-12-05" version="1">MTIISDVYAREVLDSRGNPTVEVEVSLESGAKGRAIVPSGASTGAYEAVELRDGDKDRYLGKGVLKAVENVNASIAPEIIGYDALDQVAIDRKMIELDGTPNKANFGANAILAVSIAVARAAADALDVPLYTYLGGFNAKTLPVPMMNIVNGGAHADNNVDVQEFMVLPIGLPTFSEALRAGTEIFHALKSVLKAKGLNTAVGDEGGFAPNLGSNEEALSTIIEAIEKAGYKPGVEIFLGMDVASTEFFKDGKYHLEGEGKSYTSAEFVDLLASWVEKYPIVSIEDGCSEDDWAGWKLLTEKLGDKVQLVGDDLFVTNTERLSDGIAQGVGNSILVKVNQIGTLTETFDAIEMAKRAGYTAVISHRSGESEDSTIADIAVATNAGQIKTGAPSRTDRVAKYNQLLRIEDRLASTAIYGGKDAFYNLKNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFB1</accession>
    <name>A0A398CFB1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HintN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_13915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01876">
        <property type="protein sequence ID" value="RIE01876"/>
        <property type="gene ID" value="D3H35_13915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017273018" description="HintN domain-containing protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="2089"/>
        </location>
    </feature>
    <feature type="domain" description="HintN" evidence="3">
        <location>
            <begin position="1845"/>
            <end position="1941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE01876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="2089" mass="235796" checksum="5DA444B4ACD60D96" modified="2018-12-05" version="1">MKNRLSKKIIISFLFVVVLIQSSLPFGNVYAASSNSKVLSVNGLKEVPVDDMAEINPFEGTEITITDKDSKNELTQKVSASKSKADKDRQTAKKNLSSDIYKIGAYYYPDFFETLSDTEKLEVLDWNYDIVQQKMASLSNKQKQQLKSYAPIAYEAYLSTLPEATSNSSSLTEEQEEAYREHVRNIMKDSQEQIEQKTKELQQTNPDKSKTSKSNERGEVRTLASSQYTINERKTQYNYKVNSDEVVDPLYRTANQKSVDLFLNGKKGLDFSLVRTYNSMNSKLFSPQMIAYYGDNVYSQGSKNYTTSINDSVIANDPNFIATGWSLNIPTMSVQYIEADLNSIRRTNACASSTSTEGSCESVWYIFFPNKVDGVDKGYDKVTFQLDSGNSVEFKDFYGAIGLSDYTKKTLSATEYPYQNVTAYKQRNASLSGAVEYVISIDNEIFYTFDASGKIKSKKNEYGDQITYTHTENVLTIKDSYNRDIVIQRNLTTKNVMGFSASIGSTAIKSGQYVVERKIKDSALLKHFGVDTNIANSPYWTLNSVTYTVKGETKTIASYTYKDLSLDTAADFNLGPQGYYYYAQSDAEATVQHPFCSCTKGQNNVILWNNDGIVDNFFETVQVETRRAETYGETMYLLLNTVTLYNGLEIQYTYDKYIRAWPTISLTTIGNREQTRGTTRLFMDQFALQYISYHAVNQVNYKYTQDGVTKVLTDTYISYNKVKNYPINEVLKSHNSMYGDTNYRLHLATRYGHQQIIETRSPGTESGKTRSSYQKFEIHDNIAKFRHMNLTETWTEQGTDYNPFSAIDTANQIQYENDNKANTYYGYEYDGLNLTSVSNKGSASNNSLSTLVQDTTYDTWGKVLTEKDAKNNTVTYEYNGPNHHLSKKTQISADSAYKGIEEYEYYPANDANVNRRNELKKTTITQQYPDPNLTGVVNSDTITTEFLNYNANRQVISTKASSSGAQFGQSSVNTESEFTYTAVGQLDTEKVKVTLKEGSPQSNVIVDYDYDAQGRLIKKTYPDGNYEEFEYDALDRTKLYRVKPVNKPERVTAYTYSDSSRTFTTLNPDGTESISTFTPFGLEIKQQVKKDSDVRLMLVNETYDGLNINKSKPYGDAAYATTYTYDSLGRIKTTVNPAAETTTYYYSNSAKNLATNKSTLQNTVKAVQPDGKEEISYYNPLGELVKATATTPDAAKNIIATYTYSKLGQLLEQKATSGGVAQTTKFAYDSFGNLIKVNDAEGQTYSYTYDWMGNLIRSKTGTKTTNYSYNEAGWRMKSLETDDVQQTYAYKINGLVDYYVDANGKKHQYEYSTAYQVEAYKVYNGSNQLELSETYQYDPVTYLVSNETNSANETIGYIYDKWGNLDTFTVANRVYDVNYDSNLRFNSLKYPDQSEVLYTYDTSNRINSVSYPGMGTITYAYTKGSNNSSYTIQYPNNNKQVKQYDAFGSVTTMQSYLNNSTTPNWSETYGTDGFGNIKTIQKGTTTRTFQYDALNRINSETALSGQLTYTYDDMGNRSSLSNSLAMPSAPAGIESLSTYTAKNQLATYASNGVSSQYTYYPSGLRATKKVGSETTRYIYLNGQIIEELDGSGNVKARNVWGNELLYRQDKTTNQQGYYYYNGHGDVVSIKDGTGNPINSYEYDTWGNFTSKTETMSNPFTYTGEVYDNETGYIYLRARYYDPSIGRFITKDTYEGQLDNPLSLNNYTYVHNNPLINIDPTGHYCVSADGMNAHSGLCKDDSNKPTRQITKDTSMINALPYIVDGVVKGYYNTEGNLVMFPEDKWANQTFWSIISEKEYNDLYVLYASYSGSPPPTTNTWNNSNAPSLRYNGGKTSGKSSGKVSSCNCFTAGTKVQTDEGEKNIEDIEVGDKVLSKDENNPNGELAYKEVTGLYRNQRDDIIKLHVGEQVIETTNNHPFWVEGKGWVFADELQVGDKLQKADGSNLMIDEVEFVKLDEPVTVYNFTVADYHTYYVTDIGIWVHNTNCSILNWRSGSADHVKLHLKPNANKDYHGVFKSNNPISVVNQAWNTIKKSGMLPFKTENGRDIYRIRIDNVGVGSGKYDKGKTLNYLEIIVDKGTNNMVTAYPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFC1</accession>
    <name>A0A398CFC1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_23055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01270">
        <property type="protein sequence ID" value="RIE01270"/>
        <property type="gene ID" value="D3H35_23055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="131"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="131"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="231" mass="25951" checksum="16D3294EC6D06E63" modified="2018-12-05" version="1">MSVQILLVEDDEALHRGIQFTLQQEGFAVSSARSLADARLALAEQQIQLILLDVQLPDGNGFDFCEEIRRLKDIPIIFLTASDHEIDIVRGLDLGGDDYITKPFRLREFLSRIQAVLRRRVPGNAARVEDSGALSSGGLKLHRAEMRLDKQGIEIPLSLTEFRMLALFMSHPRAVLSKEQIISQVWPDGTDILDDNTVAVNIRRLREKIEPDPQSPTLITTVRGAGYRWNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFI4</accession>
    <name>A0A398CFI4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_27250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. EmrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00662">
        <property type="protein sequence ID" value="RIE00662"/>
        <property type="gene ID" value="D3H35_27250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="10"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE00662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="418" mass="44204" checksum="D1B9869FE4F16F86" modified="2018-12-05" version="1">MNVQKHSFLMMTAICLGAFISHFTAGIVNVSLPHMTKVFETSLESMQWLTTGYLLVIVSLLPVMGKLGDRYGHRSVHNAGFALFAVSSVLIAFSPNMLVLLIFRMVQAVGAAMFQATNIALIALHMPKENRGRALGIVSTAVALGGMTGPVAGGFIAERLSWHWLFWIHVPIAFLATGLAWRYVPAHGQQRKSVPLDAAGMVLFAAVIGSVLFGLSNAAAWGWLSVEMIVLFVAAFTAFRLLLLRESRQAAPFLPLKVFRIPAVSFGLIISCASFAVANAVLVAMPFYLSGVADISPITAGKIMIAYPAALALSGPFAGHLSDRYGSRAFMFAGFVCMGAGLSVFSFFPDSLPIVIIIGILAIIGMGMGLIAAPNNSYMMQKAPIEHAGSIGGMIALTRNAGMALGAALGLGVMIVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG22</accession>
    <name>A0A398CG22_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_24125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01450">
        <property type="protein sequence ID" value="RIE01450"/>
        <property type="gene ID" value="D3H35_24125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="303" mass="31904" checksum="A5FD7FDD68A6EB91" modified="2018-12-05" version="1">MIADILTGAIRSGTSVMLASQGELVSERAGVINLGTEGSMLGGALGGFAVTVWTGSPWLGALAGGLCGVLIALIHAFLVLSCGANQLATGLTIMFFGMGVTAFFGRDFVSEQIVGFNPVAIPLLSDIPFLGPILFDHDPLTYLSILLVPLLWFIIFRTRVGIMLRTAGEREEVLFASGINPKLVRYLAVLVGGFLAGLGGAQLSVAYTHSWVENMTAGRGVVAVALVIFASWKPARAMLGAYLFGAAQALQLTVQQQGLAISPFFLFMVPYLLTLLALLIVERRQKSQTPEALGKVFAGEAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG59</accession>
    <name>A0A398CG59_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF951 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_24085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01445">
        <property type="protein sequence ID" value="RIE01445"/>
        <property type="gene ID" value="D3H35_24085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009296">
        <property type="entry name" value="DUF951"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38455">
        <property type="entry name" value="PTHR38455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06107">
        <property type="entry name" value="DUF951"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037263">
        <property type="entry name" value="DUF951_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="72" mass="8238" checksum="AC927DB9D6A89C9C" modified="2018-12-05" version="1">MEPKVFNLHDVVQMKKQHPCGANEMEIIRMGMDIRIKCVKCKHSILLPRAKFEKSMKKVLRAGEGTAVEEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGY0</accession>
    <name>A0A398CGY0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01715">
        <property type="protein sequence ID" value="RIE01715"/>
        <property type="gene ID" value="D3H35_12965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="438" mass="47886" checksum="02DC6DA97FEE82A5" modified="2018-12-05" version="1">MKSAAAVHTIFDILRGTKQMHKGMKKLAIATAAMSLILTACGTSNDNASDANKNGGAASGDKVTIQWWDSMTSEATQGALSKIIADYETAHPNVKIERTFISFADIKNKLLLSSAGNQMPDIVWLDNPDHQAFAAAGILADITEEVKAWGQADKYFDGPWSSTVYQGKNYGVPIGSNNLALYYNVDMLKAANVTPPKTWAELLEAAKKLTTKDVYGFSMTAVKTEEGTFQFLPLMYQAGSDITNFNSEGTVEAAKLLQNMASNGYMSKEVINQKQSDTVVQFSTGKVAMMMNGTWQIPLLRKEGKVNWDVVELPINKQGGTILGGENWAITKASKHKDVAFDIIKFANEPDNLKSFLQAAGRLPSREDYLSDPFWQDDKQLKVFADSMKVAKARAYGPNYPKISDAIQIMLQEVITGAKSPEDAVKAADAKIKPNLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH05</accession>
    <name>A0A398CH05_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02486">
        <property type="protein sequence ID" value="RIE02486"/>
        <property type="gene ID" value="D3H35_17465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="279" mass="30275" checksum="2FB6789371C2FCF2" modified="2018-12-05" version="1">MQKIIIVTDSTTDLPKELLEQHRIEVIPLQVDVNGKTYLDNVTISPLTFLEQMKLSTELPRTSQPSVGAFVEAYDRLGVGGETILSIHMTGGMSGTYQTACMAAEMSTSNVQVVDSKMISQALGFQVIEAARMANEGSSVQSIVERLKDIFDRTALFVVVDTLEYLIKGGRIGKAAGWIGSLFHIKPISRLQNGVISPVSKARSYVQVIQSLMEQFAQDTKGKTIRGIGISHADNLSVAEKLQKQIALMTGVPVRICPATPVITAHTGPGAIGFMYYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH76</accession>
    <name>A0A398CH76_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 15">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="8">IMP dehydrogenase</shortName>
            <shortName evidence="8">IMPD</shortName>
            <shortName evidence="8">IMPDH</shortName>
            <ecNumber evidence="8 15">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">guaB</name>
        <name evidence="17" type="ORF">D3H35_23370</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 15">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 14">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="8 15"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01322">
        <property type="protein sequence ID" value="RIE01322"/>
        <property type="gene ID" value="D3H35_23370"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 8 15" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11 15" id="KW-0520">NAD</keyword>
    <keyword evidence="6 8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 8 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 8 15" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="95"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="155"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8 10">
        <location>
            <begin position="339"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8 10">
        <location>
            <begin position="362"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8 10">
        <location>
            <begin position="386"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="8 9">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="249"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="299"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 12">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 12">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 12">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RIE01322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="485" mass="52190" checksum="1870D3A822B7CF30" modified="2018-12-05" version="1">MWQNKFAKEGLTFDDVLLVPRKSTILPRDVDVSIVLSPSVKLNIPLVSAGMDTVTESALAIAIAREGGVGIIHKNMSVAQQAQEVDRVKRSESGVITNPFSLTPDHHVYDAEELMGKYRISGVPIVDNAGKLVGILTNRDLRFVHDYSIKVSTVMTHEDLVTAPVGTTLQEAEVILQQHKIEKLPLVDEANTLKGLITIKDIEKAIQFPNAAKDRHGRLLVGAAVGVSKDTFERAEALVQSGIDLLVVDSAHGHHIDIVSMVRKLRDKYPELTIVAGNVATGEATRDLIEAGASVVKVGIGPGSICTTRVIAGIGVPQITAIYDCATVAREYNVPIIADGGIKYSGEVTKAIAAGATAVMMGSLFAGTEESPGESEIFQGRRYKSYRGMGSIGAMKEGSKDRYFQENESKLVPEGIEGRVPYKGPLKDTIHQLIGGLRSGMGYCGTGSIDELKNDTQFVRITGAGLRESHPHDVLITKEAPNYSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHA4</accession>
    <name>A0A398CHA4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysM peptidoglycan-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02586">
        <property type="protein sequence ID" value="RIE02586"/>
        <property type="gene ID" value="D3H35_18050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045361">
        <property type="entry name" value="CIS_tube_prot_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19266">
        <property type="entry name" value="CIS_tube"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="157"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="208" mass="23518" checksum="175E1D208D360C0C" modified="2018-12-05" version="1">MSLTKAKIIIIKSNSQETVDVLFNPNEYVLQSGNTFSWQTIPGLQSPIAQFVSGEATTLTMDLFFDTYEKGTDVRAHTAKVTGLLNVDRDLHAPPLCRFVWGSLDFKGVAEKVSQRFTMFLNSGIPVRATLNVTFRAVQSMTEQYQNVPRQSADRTKQKTLKQDEQLWMLAAEEYEDPSHWRAIAEANGIDNPRKLPVGRKLTIPRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CI12</accession>
    <name>A0A398CI12_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_21970</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01652">
        <property type="protein sequence ID" value="RIE01652"/>
        <property type="gene ID" value="D3H35_21970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="360"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE01652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="580" mass="65635" checksum="948BE3557F604CED" modified="2018-12-05" version="1">MKIQRRLAFQFTFQLIIYSVLIIAITLVFVIAFTEQLSKSEIKNNFPHGALDMMVTEAVTEDTLSLSDFWTRLIEERRMWLQVIDENGVVVYKVNVPASQPSSYSVAQLLTITDTERFGPYTVNSQLDDSSESPYLFLLGYENPKLEQLISWFDAYQSKGLVNDAAKDGLLEQLSASDGYLTIVNDHGEIVQTIGDPSLTPKAFKPLELLSMRQSPDNYDTGVIAYQPESAAITWILHTPNDTYRVSDIPELKDAIGVMIAIAGVALFLSLASSIWHGYRYGRPLLLFAGWFERMGQGMYDSALSPRERRIVFRRNGKLRVRFRLYKEVIQSFHSMAEKLAQTEKDRALLDKTREEWMTGISHDLRTPLSTIQGYGYILENKPDGWSPEELQEMGTMIREKGDYMLELIRDFSYVFQLKQASFPFERERIDIDELLRRSVLKYVNDATLAEAEFVYDGEERPVPVLGNAMWLQRLVDNLLSNAVNHNLPGVIVTVSSGLIGGEAYIKVSDNGRGMDEETKRNLFERYYRGTNTEESTVGSGLGMSIAKMIAEAHQGRIEVRSSVGSGTEIAVFFALAAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIA4</accession>
    <name>A0A398CIA4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_27930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00568">
        <property type="protein sequence ID" value="RIE00568"/>
        <property type="gene ID" value="D3H35_27930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="359" mass="38387" checksum="AF1E65F59CEB043A" modified="2018-12-05" version="1">MNKFVQAFTKDSAIVPLIAILLGLLFGAVIMLIGGYDPILAYTSLFDKVFGKASDFGETLRTIAPLILTGLSIAFAFRTGLFNIGAEGQFIVGMTAATFIGVKIDFMPWFIHAPLAVVIGALAGGFWGMIAGYLKAARGVNEVITTIMLNWIALHLANYIVNAFLKEKGQARSFKIHDSASVSIDWLTEWMGNARMHWGMLVSLLAVCVFYVILWRTKQGFELRMVGRNPHAALYAGVNVNRGIVKAMFISGAFSGLAGAFQILGVFKYQAISAAMPGYGFDGIAVALIGGNTPIGVLLGASLFGALSYGSAGMSFGADVPPEIIRIVIGSIIFFIAAPGIIRWMIRLVAGKKSKGEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIH8</accession>
    <name>A0A398CIH8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP2_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_21325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE00999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00999">
        <property type="protein sequence ID" value="RIE00999"/>
        <property type="gene ID" value="D3H35_21325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025559">
        <property type="entry name" value="Eis_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13530">
        <property type="entry name" value="SCP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="94" mass="10380" checksum="7B05822D27589DAC" modified="2018-12-05" version="1">MAIRVEDERADWNDGWFRLTIPANGRSALVERTEMAAPGIPSAACDIQTWTAMLAGGRRPAAFASVGRLKAEEEALAIMERRIPRGPTYLADFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIK5</accession>
    <name>A0A398CIK5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_21495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01029">
        <property type="protein sequence ID" value="RIE01029"/>
        <property type="gene ID" value="D3H35_21495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="158" mass="17321" checksum="08949CD9CF1D1241" modified="2018-12-05" version="1">MRNVERYPVEGPNALWQVYRTVSPFKAVRNFIFIQLARYCPILPVKNAIYRRVLGMKVGRHTAFALMVMVDVFFPERITVGDNSIIGYNTTLLTHEYLIKEYRIGPIVIGENVMIGANVTVLPGVTIGDGAVVAAGAVVHKDVAPGAKVGGNPLRELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIL2</accession>
    <name>A0A398CIL2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TVP38/TMEM64 family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_15900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02220">
        <property type="protein sequence ID" value="RIE02220"/>
        <property type="gene ID" value="D3H35_15900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="PTHR12677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="201" mass="22587" checksum="9754FAC01EBE5787" modified="2018-12-05" version="1">MSWLSGSEWFEYAKNMKLEDIQGWLDRYSALGPLPGIALPLLEALLPFLPLVVFVVANASAYGMWAGFLYSWIGVCVGSLLVFMLARKFGNKYGDRIRKRFPKSEKFFGYVERKGFTPIFLLSCFPFSPSALVNISAGLSRMPLHTFLVSIVLGKAVMIFTLSFLGHDLRAMVDHPWRIAAAVVVLIALWLGGRKLEARYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIY7</accession>
    <name>A0A398CIY7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01169">
        <property type="protein sequence ID" value="RIE01169"/>
        <property type="gene ID" value="D3H35_22470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="116" mass="13589" checksum="9D1493E9FAC302AE" modified="2018-12-05" version="1">MSLNYVKCPVELAVDVLSGKWKVLALWYLQDQRRRFNELQRLMPGVSQKMLTQQLRELEKDGIIGRQIFDENPPRVEYYLTERGEAVKPILSSLFTWGLTVESAEDQNRRLESSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ29</accession>
    <name>A0A398CJ29_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01229">
        <property type="protein sequence ID" value="RIE01229"/>
        <property type="gene ID" value="D3H35_22815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="19"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="109" mass="12790" checksum="4462B203D83D91C6" modified="2018-12-05" version="1">MSENKITSDLLRGHTDTMILRLLSEADRYGYEIVKLIAERSGGEYELKEATMYSSVRRLEVDGDIEWYWGDESQGGRRKYFRITEKGKAAYARNKSNWEYAKRVLENLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ49</accession>
    <name>A0A398CJ49_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01249">
        <property type="protein sequence ID" value="RIE01249"/>
        <property type="gene ID" value="D3H35_22935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UPF0020" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="165" mass="18240" checksum="704074BA2A8C7255" modified="2018-12-05" version="1">MRPTVAAVLVRISQPSKNDVCYDPFCGSGTIPDERAHLPARRILASDIDEGAVMVAEVNCRDSVVVFHADARKTPSQSESVDIIISNPPWNKQIAVGDVRALYAEFMAEAARILKPHGRIVLLTDCHEEITAASTENGLRLYERHSLSLHGLHPKVYELRKEISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJH5</accession>
    <name>A0A398CJH5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bifunctional AAC/APH</fullName>
            <ecNumber evidence="4">2.7.1.190</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_25645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region. The C-terminal region is a kinase that phosphorylates several 4,6-disubstituted aminoglycosides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a gentamycin + GTP = a gentamycin 2''-phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48872"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:90218"/>
            <dbReference type="ChEBI" id="CHEBI:90219"/>
            <dbReference type="EC" id="2.7.1.190"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the aminoglycoside phosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.190" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00988">
        <property type="protein sequence ID" value="RIE00988"/>
        <property type="gene ID" value="D3H35_25645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034071">
        <property type="term" value="F:aminoglycoside phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="7">
        <location>
            <begin position="327"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE00988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="470" mass="54611" checksum="4F659A1B2967B28F" modified="2018-12-05" version="1">MSLKNRVRGSENDSVANQLIQSWEHDSDTLKFRRASSNFIYSFERNGIRHFLRFIHEEDNTIEKIQAELDFMLYLLANGYPTVAPVLSKNGNRIETIRAADNGCYYGVVFEQAKGIHLPLDRMTDRHAQEWGRSLASMHILSGAYTSGEAKRGSWLDALTFVSSVLQRHPCEEGARRELEQVRRQLSELPASAEHMGLIHYDFETDNIFYDEEESRYCAIDFDDAMIHWYAMDIVSAIADLTEQEEDNTQRKIEHFLSGYRSIKPLDECYVELFPLFQRFSDLYTFARLFRSVEDMDVQSSPEWAIQLKDKLLKVCDRIRERFRPTVELRPVDQSNWYTCTQLEVTDEQKNVFPVPVVYWLAESAYCGFTPLAMYTGEQLVGFAVCAIDPEDGSNWIMAYMIDHKFQHRGLGRSGMEELIRYMKEKHGCDKIVLGHRTENKRASNLYASLGFVEVGRDEREVIRELKISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJJ1</accession>
    <name>A0A398CJJ1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_12625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03486">
        <property type="protein sequence ID" value="RIE03486"/>
        <property type="gene ID" value="D3H35_12625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="136" mass="15066" checksum="105E80427DE2B4FC" modified="2018-12-05" version="1">MIARSRSTFLPSCTLHLWRHRNVGGVSGEELVFTIVPQTAAAGASPVDIAIDHEEGVTVMPDREAIWNAIQESYTAQYLQIIKVKTLPAIFQLPEGRPEAERLSEIVVELKRDGERSVSVSLNPESLEVEASLPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJN5</accession>
    <name>A0A398CJN5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">DNA polymerase I</fullName>
            <ecNumber evidence="3 12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">polA</name>
        <name evidence="16" type="ORF">D3H35_20080</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Single-chain monomer with multiple functions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3 12"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02913">
        <property type="protein sequence ID" value="RIE02913"/>
        <property type="gene ID" value="D3H35_20080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018320">
        <property type="entry name" value="DNA_polymerase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00593">
        <property type="entry name" value="pola"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="53EXOc" evidence="14">
        <location>
            <begin position="6"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="3'-5' exonuclease" evidence="13">
        <location>
            <begin position="307"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="POLAc" evidence="15">
        <location>
            <begin position="648"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RIE02913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="891" mass="98252" checksum="5B9C49B227933D86" modified="2018-12-05" version="1">MGNGTDKLVLIDGNSIINRAFYAIPPLTNGSGLHTNAVLGFTTMLLKVLEEEKPSHILVAFDAGKVTFRHEGFAEYKGGRQKTPPELSEQFPLLKELLPAFGISQFELAGYEADDIIGTLSRVAEEKGGSVVIVSGDKDMLQLASDQVTVLITRKGVSEVERFTPEDVNEKYGLTPAQIIDLKGLMGDASDNIPGVPGVGEKTALKLLHEYGTVENVLEKVTELKGKLRENIENNMDSARMSKQVATIFREVPLEKTLDDAAYSGYQSAELVGALRKLEFKSLIERLDLVGAVSEDAGAAGSEPLAYEIVLVEEAGWGELNDALAANVDSLIVESNGDNPHQAEGIGLAVAAGEKIYFVPWELLTAADAGPLRAWLGELSAAKSGYDLHRDELVLARAGIELRGLAFDALLAAYVLDPTEADPSIGGLLSRHGLASIAPDEAVFGKGAKFRVPDRERLAKHLAAKADAVRRLKPLLVEEMEKQSMHRLYYEVEQPLSVVLAGMEKQGISVNGEALQELGAEFQRRIEEIVSAIYKIAGFEFNIGSPKQLGEVLFDKLGLPVVKKTKTGYSTDAEVLEKLEPYHEIVRQILLYRQLAKLQSTYIEGLLKEIRPETGKIHTFYRQTIAATGRLSSQFPNLQNIPIRLEEGRQIRKAFVPSEPGWRILAADYSQIELRVLAHISGDEGLKEAFRNDMDIHTKTASDVFGVSPDQVDANMRRSAKAVNFGIVYGISDFGLSQNLNITRKEAAAFIEQYFSVFQGVSRFMETIKQQAKQDGYVSTLLDRRRYLPDIRASNFNLRSFAERTAMNSPIQGTAADIIKLAMLRMDEALRERGLRSRMLLQVHDELVFEVPEEELELMSKLVPEVMESALKLDVPLKADVSHGSNWYEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJX2</accession>
    <name>A0A398CJX2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CpaF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_18370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02645">
        <property type="protein sequence ID" value="RIE02645"/>
        <property type="gene ID" value="D3H35_18370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="143"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="467" mass="52777" checksum="3F42C977316BDF5A" modified="2018-12-05" version="1">MDSSKRFSSTAYAAELQVSNGAAEASAPGRSGGDGLSSFRALTEEVRHMLSSPRGWSEEERRLYAEKLNRAVIGFPQERAEMLAVISDWLIKRRMQHVSFGSLPYQSLAEALFSEVIGMNELELVFRNREGLEEVQVVGTRIFEIRDGGAVPSPYRFQSAAHVERIQQNLVLFNNDRINPRKRWAEVILLDGSRVTMTGFGFTAQPTLTIRFYTVRRFDLEALCKPEYRTIDENMRQLLLCIVRSRLNMVVIGATNTGKTHLIKALISAMPDEERIVTIESRYELMLARDFPSKNVVEYEAEEDDPLHGPRQAFKLALRQSPQRICHAEIRDEDANIYVRACTRGHEGSITSVHVSGLEDVPDAIADMCMLDGRGMNPVRLARRIAEHVTQIGFEMRIAGGVRRLVRVGEFEWLEGEIRVRELARYDEACDSWTFPEPFSPKSALRIKRMDSEGFAFLAGLGSVSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK12</accession>
    <name>A0A398CK12_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_24565</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01529">
        <property type="protein sequence ID" value="RIE01529"/>
        <property type="gene ID" value="D3H35_24565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="3"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE01529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="377" mass="41751" checksum="DBEDA401ACF4BF40" modified="2018-12-05" version="1">MTIYLDFNATTPIDERVLQEMNDVYRNNFGNAGSRTHVYGQMANKLVEKSRREIALLLQVDSNEVIFTSGATESNNLTLLGLAEWGLENGRTHIISSQIEHKSILEPLELLSKKGFEIELVPGNKSGRIDSNEIIRRVRSDTLLVSMMHANNETGIIQPVAEVGDFLRETPTYFHIDAAQTFGKLVEELQLIHYDFLSVSAHKIFGPQGIGALVARRKRFQFPPIQPLMLGGGQEFGLRPGTVPVALVAGFGKASILAHQEYNARKISTQQIRESIISQLSEIPHLINGDMQFGLSSTLNVSFPGIDSEALMLTLEQDLALSNGSACTSKEYKPSHVLLSMGFDEHTAHSAIRLSWGYATNEVNLEPLIAFVKDFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKB2</accession>
    <name>A0A398CKB2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2225 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02740">
        <property type="protein sequence ID" value="RIE02740"/>
        <property type="gene ID" value="D3H35_19035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018708">
        <property type="entry name" value="DUF2225"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09986">
        <property type="entry name" value="DUF2225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="233" mass="27291" checksum="7834A56C71B15818" modified="2018-12-05" version="1">MEPLYQITVTCICCDASYSTSRVRPSFKRSIRSDTDFCSYFKEINPDFYVVRVCPYCGFASTESFGEKLKETQKNAYYEKIGKQWKMKDYGTERTEQEAMECYKLSLLTAQVIGERDRVIAGLLHHIAWLYRYAGQKEQELRFIAFAKDAYIRVYETESVSYSNARLLYLIGELNRRLGNFHEAVRWFSRVIHDKKIVDASMIRASREQWTAIREEMTGKGMDLPEEMQQSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKG0</accession>
    <name>A0A398CKG0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_4-like_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03796">
        <property type="protein sequence ID" value="RIE03796"/>
        <property type="gene ID" value="D3H35_09590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="24"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="148" mass="17253" checksum="E3E102F2014E27B3" modified="2018-12-05" version="1">MMSSRIRKIAVIAYELPSPKERTGGVSHFNHRFCNMLSERGYDVTAFTVRPEVPGAEYRVKVIPGERAGGRLNRYYKAPLQARGLELGEYDLVVSSGDDWAMRRGRSPWIRIMHGSAWRELQHNKRPFGKRIWRCFTCWSCCRRFGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKI3</accession>
    <name>A0A398CKI3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2757 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01388">
        <property type="protein sequence ID" value="RIE01388"/>
        <property type="gene ID" value="D3H35_23760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020115">
        <property type="entry name" value="Fin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10955">
        <property type="entry name" value="DUF2757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="76" mass="8722" checksum="30363BD2D72CD96B" modified="2018-12-05" version="1">MAVDYVCRHCRTPLGRFENSEVPEYRLGLHFLTPAERKRIIAYNSNGDVTINVICEYCSQTLDSYPELSLLSNPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKI9</accession>
    <name>A0A398CKI9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RidA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01398">
        <property type="protein sequence ID" value="RIE01398"/>
        <property type="gene ID" value="D3H35_23810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="132" mass="13918" checksum="ADB957BB2CDD4240" modified="2018-12-05" version="1">MSLKIISTPSAPAAIGPYAQAVRIGDLLFTSGQIPLTAAGELAAGGIAEQTHQVLANLKAVLSAEGAGFSDVVKTTVFLKDMNQFAEFNTIYASYFGDHTPARSTVEVARLPRDVFVEIELIAAIPVESPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKM8</accession>
    <name>A0A398CKM8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_18780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02702">
        <property type="protein sequence ID" value="RIE02702"/>
        <property type="gene ID" value="D3H35_18780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="183" mass="20160" checksum="88E956DFB0A55DFE" modified="2018-12-05" version="1">MIGPEQRSVEEPVAESTVRGPRDGFTESLGVNLPLIRKRLKTPDLKVAGMTVGSYSRTEVAVVYIKGIADPALAGEIKRRIEGMRIEGLLESESIEEWISDNPVSPFPQLLSTERPDVVCANLLEGRIAILIDGTPFALVAPVSLFSMLQSPEDYYQNILSSSFIAGFAMFFSSCRCCFRRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKP4</accession>
    <name>A0A398CKP4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Flagellar M-ring protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fliF</name>
        <name evidence="14" type="ORF">D3H35_11365</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The M ring may be actively involved in energy transduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the FliF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03283">
        <property type="protein sequence ID" value="RIE03283"/>
        <property type="gene ID" value="D3H35_11365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009431">
        <property type="term" value="C:bacterial-type flagellum basal body, MS ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013556">
        <property type="entry name" value="Flag_M-ring_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000067">
        <property type="entry name" value="FlgMring_FliF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006182">
        <property type="entry name" value="FliF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043427">
        <property type="entry name" value="YscJ/FliF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046">
        <property type="entry name" value="PTHR30046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01514">
        <property type="entry name" value="YscJ_FliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08345">
        <property type="entry name" value="YscJ_FliF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004862">
        <property type="entry name" value="FliF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01009">
        <property type="entry name" value="FLGMRINGFLIF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00206">
        <property type="entry name" value="fliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="14" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF" evidence="12">
        <location>
            <begin position="46"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF_C" evidence="13">
        <location>
            <begin position="259"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="304"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE03283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="522" mass="56422" checksum="85A8BB9AE9B76191" modified="2018-12-05" version="1">MNEKLGQVRERLSGFWNQYSKKQKAVLGGAALLLLLTIILLTYAFTRTEYELAFQNLDNTDAQSIIQYLDAEGISYKLGADGSSISVPSAAASRVKVAVGSQGLVQQGSIGFAEMTKGSSAIGTTDNEFKVKYRNALNGEIQQLLLGMQGVQRAKVLVNLPEESVFLSDQDREKATASVVMTFKPGFRPKQEEIDSYFNLVKTAVPNLDVDGITITSTSGELTPSNGGSNANSSGIVETQFEIRRKFENDIKRNIQSFLNPIVGMDNMVVSVVSTLNFDKQVTEVNKVEPLPNNDNKGIVISEKTSNESYTGQSGQTGGVAGTGETDISNYPGGTTSEGTSSEKTSTTTNYEPTRIKDQIEYAPYKVKDLAVNVAVAESVMTPEKQNAYKAMLVANVRTLLAESGLELTDEALASRVSVISQSFEGNGSVSSGVAASTYWLAGLGVLALALLGGGGYIMYRRRKASEEAKELAEMAATRTELPTIDIDNVAGESQVRKQLESLAKRKPEEFVNLLRTWLVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKS3</accession>
    <name>A0A398CKS3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_19990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02900">
        <property type="protein sequence ID" value="RIE02900"/>
        <property type="gene ID" value="D3H35_19990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="184"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="291" mass="34138" checksum="F6F4DA27C64DAB07" modified="2018-12-05" version="1">MQPVKENIKYENPLLSLKIWQVSRDTEGFINWHYHPECEILLVQSGEMDVDVGDETYHLASGDVVLVGSSQLHRDRSYDRALEYIVLQFDLQSFFDQSTIPYLQYFNETKVPLSSMNYIFKENEEARAAAFECIRQIHEEAQQKESGYELAVNLLIKKLLLLLIRNDSKGLLAGQDRMERIRLKPVLDFVETKIDERIAVEDACRLANMSYYYFVKFFKKIMGLSFTEYVNFRKIKRAEQLLLTRDLSVSEVGDQIGMANMAHFYKMFKRFNGCSPKEFQRKMLEWGRATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKV5</accession>
    <name>A0A398CKV5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00517">
        <property type="protein sequence ID" value="RIE00517"/>
        <property type="gene ID" value="D3H35_27615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="253" mass="29406" checksum="5E2EB45A27E9DEB2" modified="2018-12-05" version="1">MSAKTQQWDALPYIRHNVCAQTQQWDEVPFFRRLAGGSAQQWEEVPFFRRLAGGSAQQWDEVPFFRRLTGGSAQQWDEVPFFRRLAGGSAQQWDEVPFFRRLAGGSTHLWEEVPFFRRLAGGSAQQWEEVPFFRRLAGGSAQQWDEVPFFRRLAGGSAQQWEEVPFFRRLAGGSAQQWEEVPFFRRLASGSTHLWEEVPFFRRLAGGSVQQWEEVPFFRRLAGGSAQQWEEVPYIRRNRNNCRPSGTQKGRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKW8</accession>
    <name>A0A398CKW8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_24615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01538">
        <property type="protein sequence ID" value="RIE01538"/>
        <property type="gene ID" value="D3H35_24615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025883">
        <property type="entry name" value="Cadherin-like_b_sandwich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12733">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="251"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="615"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="676"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="2">
        <location>
            <begin position="741"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="796" mass="82039" checksum="18B76F7A37B361D4" modified="2018-12-05" version="1">MIMSDGQLYFAEYDNYVVRKIDLATGIIDVVAGNGTSGNTGDGGAADAATLGRVFSISKDAFGILYIAAENATKIVYTPGTLSGTVLDTSNNPVNGATVAIAGTALSTTTNATGSFTLNNIVPGSRKLTVTAAGYGNGEATVAINDGQSVSVGNIVIGAQVSGVTLDKPALSLAVGGAPAALTATVSPSNSADKSVAWHSSDANIATVDNNGLVTPVAEGTATITVTTADGGKTATSIVTVTHFVAMPAIVYTDAAVQQITSMTATAGGNIASDGGAMVTERGIVYSKNANPTIVDGKAVAATGGAGTFSVSLAGLQPGTIYHVRAYAVNASGISYGQEVTFATLSSSSGLDTLHLSGITLDQTVSGSVYNYTANVPNSTSDFTVTATVSDPIYGSVSASVYNSANTLVAGPVSLLSGETSTGLPLKVGSNRIELFVIAQDGTSTKYTVTITRATPNDGPVGGGPSVVLPVVSTDGKLILPVGQAGEVRLDNGLVIAVPANASSKELGLTIEKVLDAKNLLSNREILASSIYEILKNFPENFSKSVTLTFVFDPAQLKTGQTVAIFYYDEVKKVWVKVNGSKINGDRIAADVDHFTKFAVLVVDQATVLPVTEPTKEAQLSDISGHWAEANIKQAVSEGIVKGYTDGSFKPNTTVTRAEFTVMLMNALKAQDEGAELIFTDVASIGAWAKKAVEQAAKSGIVKGFDDNTFRPDAKITRAEMAEMIARAMDLSIEENAETGFADDKDIPSWVKGAVAALKKRNLIEGKGSNQFDPTAPATRAEALTIILKMLEKENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKY0</accession>
    <name>A0A398CKY0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_08430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03976">
        <property type="protein sequence ID" value="RIE03976"/>
        <property type="gene ID" value="D3H35_08430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="76"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="280" mass="31631" checksum="8CDF9A07942E01B9" modified="2018-12-05" version="1">MTQTKNKKKLERFDVISNAIVTLFAICNLFPLYWLFTSSLKNSSDVVKMPPDWWPSSITFDNYVDVFRNQPALRWAFNSLFVSGASTVMVIIVGAMAAYAFSKLRFVGRNIIFVVFISSLMIPKEIMIVPLFRITQDFGMVNSFHGMIWPNVATAFGVFLLKGFFDATPDALREAARIDGAGEWRTFTRIMLPIIKPGIGALFILNFVQVWNDYLWQLVVGQEKNMKTLMVGTATLMQDLNPNFAYKMAGATVAAIPMLLIFLMFQRYFTTGMTAGAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKY6</accession>
    <name>A0A398CKY6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_14000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01889">
        <property type="protein sequence ID" value="RIE01889"/>
        <property type="gene ID" value="D3H35_14000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="255" mass="27906" checksum="24241B7A443F7CF4" modified="2018-12-05" version="1">MCKESFWERFGRVILFQNVAKKAVKLVPDWSYRTLFRPLLFRLPARAARSLALGLFGAVGRMPGGAVVIKTLGHQEPSPLLETGWSATPVGLSGIVDPAGVARRGLARLGFGFMEIGPVTALPVESRQPIGLDAAAEQLWFPEPYENEGFNRVMAKLANPGHSLPQYVRVAPMPGLEPERTEPLTLLMMQELIFAGAAGFYVDALPPGWDLESSGRALSGVADWMEQREAELRRPLFLHVAPDIEGNGLSGFCKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLS9</accession>
    <name>A0A398CLS9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04306">
        <property type="protein sequence ID" value="RIE04306"/>
        <property type="gene ID" value="D3H35_06755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="328" mass="38488" checksum="48B1F66A75FAB797" modified="2018-12-05" version="1">MKISIAMTTYNGQRFVEKQLQSFFNQTRKPDEVIIFDDCSVDNTIKIISEFIHINKLENWKLIVNERNVGWQKNFMNAVEETCGDIVFFSDQDDIWNEDKIEIMASEMEKNNNILALSGYRTVIDEHDEPATAAYPYPISTNSKLVTKLSFNERRAFLIQSGCVTAFRRAILPHMKELWVEKFSHDILVWRIACILDGAFSIDYPVLKYRVHSSNSSGVSTSNYIGQGTVDKRIAGIRTEYKWTESFLVYFNDCNMESKENKLSILRNGLSFLKKREKFLEKRNLFTWLSLFKEIKFYQSKSKYFGDLMYAYHLNKIGGNVFWKFIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM83</accession>
    <name>A0A398CM83_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00977">
        <property type="protein sequence ID" value="RIE00977"/>
        <property type="gene ID" value="D3H35_25810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032719">
        <property type="entry name" value="WbsX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14307">
        <property type="entry name" value="Glyco_tran_WbsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BIG2" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="1">
        <location>
            <begin position="1354"/>
            <end position="1431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1898" mass="204325" checksum="A6F20A63F44C7A5A" modified="2018-12-05" version="1">MFTAGGKLCYLNAAGQPGEIYDYKPGVWYHVKVALNRAESKADIFLNGKLRAEGAELASYAGAIDGIAFVVSSVNKGTLWLDDVLLYEKRPEPADYVPVPDKVTTGDLLIGVQNCSLWREGHHFGWDTINPYPERTPYLGFYDEGSPETADWEIKWLVEHGIGYQLYCWFRPTGGEGSPIKDPYLGYGLHEGFFNAKYSDLMKFAIMWENANSNAKDSADFRSNIVPYWIEYYFKDPRYLVLDNKPVLSIYSLPSLKRDFGTVQNVKDELDYLRNAAVEAGFDGVILLCTYGGLDVQAMTDRQAAGFDAIYSYNWGYSGGHAEYQQGFLSRQKAAGIIDIVPTLGMGRDDTAWGLSSGYQTTVEEFEGIAEWLKTTFIPSLPGGSLGKRMMTIDNWNEFGEGHFIMPAGLAGFGYVDAIRNVFAGGGAHEDVLPTEAQKSRINVLYPPDRTLPKLIPASPPTATDYLKAWRFDKNGDPEGWSLDKQIDGLIVAGGAYSGTSVGSDPGILSPDDLGIRAEEVPYIHIRMNSSTPASARIYFITEADQEWSENKGESFYVAPGQPYGDYYASMWKNQSWKGYVKRFRVDPMESTGAFSIDFVGMARSWLPGMHLLVNGSLLRSGDSPVMQDGVVMLPAKDALKQVGATVEWDASSQTVIAVKDNMVLRLKVSDPTAYLNGQAIDLSHDPVLLPTGTVLIPGDFFNQAFGYSVAADETSRFVNMYTSSVLWEFNGKQGWSVRGQVSNVSADAGHYDGVSVGTEPTIVSPEAGIYIQASAVKRVRVRLKNGTAGTRAKLYYTTVGDQIWNWSKMLKGYVLSNDTGYREYVFDTTQAGEWAGVIKQLRFVAANAAGDFSIDWIKLDMATGIPVQGANLILNPGMEISSIPYSGWQITRELSTAEARSGHQSLKVTKLDVYGSIQFPVSIAKGKDYYYSAWVKLPAGAAPGKIMRLGLLYSLNGVEKQTILFSSAPMSDTEWTQVQGVYAINETGTVANTTMYLYTSVPLETDTYYLDDVEIRPVEYTASPAWVYVSGMSLNKASATIVAGKLETLAATVQPANAINKEVLWSSDRPEVATVDAYGTVYGASAGTATITARTSDGGKLALCAVTVVPDVPVTGVQLNKTAAAIPLGLSETLTATVLPANATNKAVVWSSDNANVAGVASDGTVVAKLEGTAVIQAKTVDGSKAASVAVTVPSNAVMASNLVNDPGMEGTTILYSGYKILTQLTSSEFHGGGQSLKVTATEKYGSIQFPANIEQGKEYYYSAWAKLGSDATPGVVMRACLQYKLNGVVKQLIMFTSSALSASAWKQIKGTYTIVESGVVTNVVMFMYTDTPAATGSFYFDDVEIRKIVSYSATGIRLNKSSLVLNLNAADTLAATVLPANATNKNVLWSTSDPTVATVSGNGTIQTVGNGQALIKATTADGSFQASASLIADSMPPITNAVLSPSQPDGTAGAYVGPVLVALAAADTNSGVKYTEFSLDNGNSWQTYTAPVAFEKAGVHTLRYRSADWAGNVETAGSIGFSLSATRTRVRLLDSAGNPVGGGIVKYYDGGWRDLGVTDSSGTAFLSLPEKSYTFSMSYEGTYKETVQNTGTNATVVFQTVSVKVRLQDSGGNLLDIGAAKYYAGSWRTFGSTSGGEAEKELLPGSYTFAMTYEGTYKELVQNTGANPIVVFQTANVRVRLRDSIDNPLDVGAVSYYAGSWRTFGSTSGGEAGKELLPGSYTFAMTYEGTYRELVQNIGANLIVVFQTTNVRVRLRDSTGNPLDVGAAKYYAGSWRTFGSTSGGEAGKELLPGSYTFAMTYEGTYRELVQNIGANPIVVFQTVSVKVSVKDGAGQAVEGILVKYYAGSWRMVGLTISGEAVKELLPGTYTFGAAYGGVNKTIVRDIAATPAFDIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM84</accession>
    <name>A0A398CM84_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_14155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01918">
        <property type="protein sequence ID" value="RIE01918"/>
        <property type="gene ID" value="D3H35_14155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="87" mass="9172" checksum="3D788489A649E1D2" modified="2018-12-05" version="1">MVQRTGNENPYSSANSRADFCAVGAVRLMAMYGQFFFSIVQLTISELRPCKTGTRTAKNSDGGLAAGMPPLNKAAIDPGEGESDGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM94</accession>
    <name>A0A398CM94_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_09475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03773">
        <property type="protein sequence ID" value="RIE03773"/>
        <property type="gene ID" value="D3H35_09475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017291633" evidence="1">
        <location>
            <begin position="31"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="2">
        <location>
            <begin position="318"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="2">
        <location>
            <begin position="336"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="433" mass="47219" checksum="7C2F7CDEFFFE897B" modified="2018-12-05" version="1">MIMKKKSALALCAAVMFAFAAIPAAAGAEGAKPVDDYRIVAVGDSLTVGYQHGMTETSIPYGYVDRIYEQALFHGRSELGNYGILGLKTPGLIKLLDGAAAGTPLKVDDLENYSKDENARIIAQADSVAKKTPALKEDLAKADLVVLTIGANDMTSFLRSVISLPAADAKKKIDSEIDALLNNYATNVKTALTKLQSLAPNARFVMADQYLPLPRMQYAWSDNTEIYDYLYPNVVSKLTNAVDNLAATLRQEGVDITAVHIADKFKGHEGDWTYVLTSTERDIHPNKDGYQAMAESYADAIWHEYRKPAALAANVPISVIVNGKELNSEYKPALVNSRTYLALRDVTENLGMELQWIAKTKTAVLTKPGHVVSITAGESTMTVNGVKQPIPVAAFMKKFNNESKMYVPLAIVAQAIDYQVVYRQTLKAAFINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMR5</accession>
    <name>A0A398CMR5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA gyrase subunit A</fullName>
            <ecNumber evidence="8">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gyrA</name>
        <name evidence="12" type="ORF">D3H35_11145</name>
        <name evidence="11" type="ORF">D3H35_23960</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01424">
        <property type="protein sequence ID" value="RIE01424"/>
        <property type="gene ID" value="D3H35_23960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03582">
        <property type="protein sequence ID" value="RIE03582"/>
        <property type="gene ID" value="D3H35_11145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01897">
        <property type="entry name" value="GyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005743">
        <property type="entry name" value="GyrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="10">
        <location>
            <begin position="12"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="799"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GyrA-box" evidence="8">
        <location>
            <begin position="525"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="810"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE01424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE03582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="824" mass="92911" checksum="2504F817C1F508C7" modified="2018-12-05" version="1">MAEEQRFQVRDRDIGVEMRESFMDYAMSIIVSRALPDVRDGLKPVHRRILYAMSELGMAPDKPYKKSARIVGEVIGKYHPHGDSSIYEAMVRMAQDFSLRYMLVDGHGNFGSIDGDFAAAMRYTEARMSKIALEMLRDINKETVDFIPNYDGEEQEPSVLPARYPNLLVNGNTGIAVGMATNIPPHNLREVINGTQALIRNPELTAADLMEFISGPDFPTAGLILGRQGIRQAYTTGRGSVTMRARAEIEEVGGKARIIVHELPYQVIKARLVEKIAELVRDKKLEGITDLRDESDRNGMRVVIELRRDANPSVVLNNLYKQTAMQSTFGVNMLAIVNKEPKLLNLRDALYYYIEHQIEVIRRRTEFDLKKAEARAHILQGLRIALDHLDEVIALIRASQTAEIAREGLITRFGLSHDQAQAILDMRLQRLTGLERDKIEQEYAELMQKIAEYKAILGDEALVLDIIYDELEEIKLKFGDERRTEITHSDEEILDEDLIPRDDVVITMSHSGYIKRLPVSTYRSQKRGGRGVTGMGTKDEDFVENLFISNTHHYLLFFTNKGRVFRLKAYEIPDLSRTAKGTPIINLIQIEQGETINAVIPVEAFEPNKYLFFATRNGIVKKTPLDDYSNIRRVGLIAISLREDDDLIGVKLTDGEQEIIMGTRQGMSIRFPEKDVRSMGRSATGVKGIQLDDDDNVIDMDVVEPNEDVLIVTAKGYGKRTPMTEYRIQTRGGKGIKTLNVTEKNGDIVSLKVVHDDEDLMIMTTSGTLIRTSMSGINSMGRITQGVKLINIRDEDAVATVTRAPRSEDDDQDESEDSIEGETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMX6</accession>
    <name>A0A398CMX6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1805 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03963">
        <property type="protein sequence ID" value="RIE03963"/>
        <property type="gene ID" value="D3H35_08360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014931">
        <property type="entry name" value="DUF1805"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036493">
        <property type="entry name" value="YunC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08827">
        <property type="entry name" value="DUF1805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102891">
        <property type="entry name" value="SSF102891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="106" mass="11118" checksum="1ECF56D8609A9D99" modified="2018-12-05" version="1">MIRMEPIQIGPWTAIGVEVLLPKTTLIAITAGDGYIMCGALDVGLLNDRLRTRGIVAGRAVGVKTLEQLLHAPLESVTVAAESLGIVIGTQGSDALRIMAENASRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMY6</accession>
    <name>A0A398CMY6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal_L7Ae domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000062">
        <property type="protein sequence ID" value="RIE00284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00284">
        <property type="protein sequence ID" value="RIE00284"/>
        <property type="gene ID" value="D3H35_29460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="1">
        <location>
            <begin position="19"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="83" mass="9351" checksum="7F071A69DAE04B07" modified="2018-12-05" version="1">MSDDNERLRIAGRERQDCTKQTIKTVEQGDAAEVFVAQDADPRTVARVIQLCEQLGVKLTYVDTMRNLGKACGIEVARRWPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN11</accession>
    <name>A0A398CN11_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01297">
        <property type="protein sequence ID" value="RIE01297"/>
        <property type="gene ID" value="D3H35_23215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="321" mass="36727" checksum="7442130193E1E7CC" modified="2018-12-05" version="1">MAFEVLLDNKDGKVWDISEIISSLEWTTSRVGKPGSLDFTIVDNLINKSNFKINNGDIIRVKKDGKGVFYGYVFKLTFGESSEVKVKAYDQIRYLLYSDSYIFTGKTATEIIRKIATDFKLKVGNLADTKYKIPKVSEKDKALLDIICGALDQTSLNGQEEFFLFDNFGALELKNITETLEDYYIGDESLMTGYEYSQSIDDDTYNTFRIVRDNSQTGVREVFPAQDSVNVAKWGRLQFYRSVDEKTNDAQIKKLLSMLAALKNRETRTLKMDAIGDLRLRAGHFIYVRNDRLGIKQKMLIDECSHKFDGDHTMSLEMKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN42</accession>
    <name>A0A398CN42_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cu_amine_oxidN1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_15835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02208">
        <property type="protein sequence ID" value="RIE02208"/>
        <property type="gene ID" value="D3H35_15835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017196259" description="Cu_amine_oxidN1 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="2">
        <location>
            <begin position="53"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="354" mass="40502" checksum="F2C1409D644D18CB" modified="2018-12-05" version="1">MKKTVVILLFLLTLLSVNNRTSFAADLLPKANSQLTINGAPFKSTAPLLSKGKEVLVPLKDFVTQLKLNLEWNTEYSGYRINSLKKVILVMPNSKLANIKIISEKNYKSATAGITYEFASKIERMPAALIRQNNVQYISLQWLCKQLELKLQSNNSSLIAAGEVAPATWKNLTPLYETLKKKYEYDYFSSDLETFMKYEFNAGVNRGFIEVENKQIIALIGKKIWTNYKDTATDLTTNKVITLPRLSQITITDELSGDETIITYKNKLYKISNSFALSYFKKDPQKEFKWSAKVWNAIKEEEVFIGMTTPQALMSWGEPDDINTTTTEYGIFEQWVYGYSYLYFQNGKLTTIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN76</accession>
    <name>A0A398CN76_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03752">
        <property type="protein sequence ID" value="RIE03752"/>
        <property type="gene ID" value="D3H35_09345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="290" mass="33762" checksum="3B423A7FA0C88984" modified="2018-12-05" version="1">MINNESRYIEKILTPKDKLSIESGINSSIYFFYVGFLFLFCGLLSILSIFVFSFLNQSYATIFFVITISMIFSSIFFLFLSERDPISSKALNEKLFIYFDLLQQYIDKNKKSVQIWMINRRLIKYLYELERSLNNVFIYTNSRADIQLIINLRELIKDDFSMLLKNNEQQVVLELIKKIKQAHLSAESIHLMETMKEDGVSEHRTRVLSIKKSLENCKQKISTNAEKQSFSSKLYRLIAKPSFLIILLIIVGIIMLIYMNTTQDFSRTPANLTAIGFILAIASLTVQNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN89</accession>
    <name>A0A398CN89_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EAL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04073">
        <property type="protein sequence ID" value="RIE04073"/>
        <property type="gene ID" value="D3H35_09005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="193"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="457" mass="52670" checksum="E75CF4A48FBC4164" modified="2018-12-05" version="1">MSVQTLIEKLQLGFKLLMPDRALKFFPPDFTFRRPEIALLKKRASRDGDGYLALFRLDFSMLHQEVPNEIWDELQNGCRRQMKISAGDRLPEDSLIALRQYSRTDYALLAWSQDKKEHGAIVPFELRCSADIIRSDVEIALASLFPAWRHCLKVTVHCVPVESLAEPRGTEQALENAYQLALALATRQWTTQTEAMRKQLERFLDEGAVSVLSQPIMNLSTGDIYGWEILARGPEGSYFHMPDELFRFATQTRLLSRLEFMIVKRALEEIASRRIREPVFLNVTAVTLSHPLFLQHVLQCLEHHPLLSPKQIYFEITERHEVADLEAMAGILREFRKYGFRFAVDDAGAGYSSLQWISELVPELIKIDRSVIQQVDRVAIKESLLRALLTAAREMKCEVVAEGVEREEEADVLFRLDVAMGQGFYFARPNVLLHEHEREIFREMKEKIQLRRGQVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNG3</accession>
    <name>A0A398CNG3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ssb</name>
        <name evidence="6" type="ORF">D3H35_24170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01457">
        <property type="protein sequence ID" value="RIE01457"/>
        <property type="gene ID" value="D3H35_24170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Important for interaction with partner proteins" evidence="2">
        <location>
            <begin position="163"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE01457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="168" mass="18413" checksum="161408302978FAD1" modified="2018-12-05" version="1">MLNRVILIGRLTKDPELRYTPAGVAVAQFTLAVDRPFSREQSSEREADFIPIVVWRQLAETCANYLRKGRLAAVEGRMQVRNYENNEGRRVYVTEVVADNVRFLESPNREGGASQGRDEFAGNSGNSGGGGYGGSSRSSGPRNSGNNNQDPFADDGKPIDISDDDLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNJ0</accession>
    <name>A0A398CNJ0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Holo-[acyl-carrier-protein] synthase</fullName>
            <shortName evidence="9">Holo-ACP synthase</shortName>
            <ecNumber evidence="9">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">4'-phosphopantetheinyl transferase AcpS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">acpS</name>
        <name evidence="11" type="ORF">D3H35_16375</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="9"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02298">
        <property type="protein sequence ID" value="RIE02298"/>
        <property type="gene ID" value="D3H35_16375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00516">
        <property type="entry name" value="acpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="10">
        <location>
            <begin position="4"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE02298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="129" mass="13947" checksum="431B7E92AEB8639B" modified="2018-12-05" version="1">MIAGIGLDIVETARMEKLLNSAIRDRFAERVLTLKERERFFALPARRALEFIAGRFAAKEAVTKAIGCGIGGLVGFQDIEIMPDGSGKPVCRLSDAALDRLGWQGTGCSFHVAITHEKSMAAATAVIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNL7</accession>
    <name>A0A398CNL7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_16500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02318">
        <property type="protein sequence ID" value="RIE02318"/>
        <property type="gene ID" value="D3H35_16500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="123"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="366" mass="39680" checksum="2EAD362DAF562B86" modified="2018-12-05" version="1">MPDDNRRCPSLSENQHPSHSQSAFRRYRTAIVIGILIVVFLVANSISWPYVLYGPGSAEPVHPRVETGKKLDEKGSLLFTTVSTYSKPNVFSLIYAWLNPRMDIETEEKATGGAVNYTAYRNLLAYMRDSSESNALLAAYNVMKKEIDVKEEGVIVYTLLKESKAAEHGLQEGDIITSVDGKSTLNVTSMIDALSSKKAGDNATLKGTRGGKPFEATVPLIAMPGEQDRAGVGFKQQTVLKVTPPDPVKFDFNDTGGPSAGLMMTLEIVAQLTGEDLSRGYRIAGTGTIAHDGTVGQIGGIQYKLMAADKQKADYFLVPFDSSIGLADLDDPKLTPAQRAAMLNAIQNGHSNWTLAQQTVADLAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP09</accession>
    <name>A0A398CP09_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_25065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01617">
        <property type="protein sequence ID" value="RIE01617"/>
        <property type="gene ID" value="D3H35_25065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="64"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE01617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="270" mass="29665" checksum="2CD0634A10CFC4B4" modified="2018-12-05" version="1">MRKASLYAVLVVMALISLIPFYVLVFTAFSPSSVSLADSGLLLRHLEWGNLSDTWKQSKLGNAMLNSAIIMAGSVGLSVIVSAGAGYVFARIGTWYNKLSFNILLFSMMIPGIINTVPLYSLMKSIHGINTHWAMILLLATGFIPQSVFLYTNFIRTLSKEIEESAVIDGCTLFEAFWRISFPLLLPITSTLIILNSINAWNNYAQSVFFLQSQARQTVPLAIGRFVQTYGANYTQMAAAALIGMLPAIAIYFVFQRYFVKGISAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP62</accession>
    <name>A0A398CP62_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EpsG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04305">
        <property type="protein sequence ID" value="RIE04305"/>
        <property type="gene ID" value="D3H35_06750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="368" mass="42477" checksum="6259FC67B3CE8388" modified="2018-12-05" version="1">MIYFAYSIVVIINSFLAYSRNHSRIIAFITAVFIWLLFWSNTLNPDLQAYVRDYIYLQNNVPLETYQTEPGFIILMKLGISLGLSYTAFLSLVTAVCYALIYRTIKKYTNNMSYVYLMYLLHPVFLDIVQFRNFIIMSILVSAIPLLVEDTGKSKIKYLLLILVAASIQNLAIVYAPLLLVNRANKNKLVKYIACFIVLFSIVLLFNGNKIPYIENIVQNINNDRIDRYLSGVGRLGFLIAWGLHIIYFLLIYWSKKVIDRNKTSDKKNDEIIAFVNIVFWINVFAFAFFPLYMMDMAFYRVIRNLILVNAIVFSIASNSFASGNVKKLVFNFTVLLGASAWFSYDILGPHFITVFKPIFENNIFIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP69</accession>
    <name>A0A398CP69_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="5">3.2.1.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_06820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04315">
        <property type="protein sequence ID" value="RIE04315"/>
        <property type="gene ID" value="D3H35_06820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017466685" evidence="3">
        <location>
            <begin position="32"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="4">
        <location>
            <begin position="93"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="449" mass="47080" checksum="009AA2ACD6A4AE30" modified="2018-12-05" version="1">MIVRKLSRASTIALLLTITAGCWSLNANPNASQPSGAGSLASPTAGAAISPSVPELPSDSQPTAPSASPLSPSSSSSASPEANDIEHTLDAMTLKQKIGQLLLVGVEGTTISEETKQLLKQTHAGGVILFKGNLASLASSARLINGLKAANAGSPAPLIVSVDQEGGRVSRLPKAFVEMPSNAEVGAANNAGLTKQMGGLIAKELSLLGFNVDFAPVLDINSNPNNPVIGNRSFGDNAALVTKHGLAEMNGIQSGGIIPVVKHFPGHGDTSVDSHIDLPVVNKTAKQLAKFEWLPFKSAIESDADAVMVAHILYPRIDPDAPASFSKIIIHDQLRGKLGFQGVVFTDDLTMGAIAKNYGIGEAAVRAIQAGGDIVLVGHGYDNGKLVFDKLVQSVRDGKLTESRVDESVERILKLKRRYGLTDKAIPIPKASDIPNDRIEKWKEAVLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPC7</accession>
    <name>A0A398CPC7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase</fullName>
            <ecNumber evidence="7">4.2.1.59</ecNumber>
            <ecNumber evidence="6">5.3.3.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Beta-hydroxydecanoyl thioester dehydrase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Trans-2-decenoyl-[acyl-carrier-protein] isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">D3H35_01675</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the thioester dehydratase family. FabA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.59" evidence="7"/>
    <dbReference type="EC" id="5.3.3.14" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05256">
        <property type="protein sequence ID" value="RIE05256"/>
        <property type="gene ID" value="D3H35_01675"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008659">
        <property type="term" value="F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008693">
        <property type="term" value="F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047451">
        <property type="term" value="F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004317">
        <property type="term" value="F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034017">
        <property type="term" value="F:trans-2-decenoyl-acyl-carrier-protein isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01287">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010083">
        <property type="entry name" value="FabA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="PTHR30272"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272:SF8">
        <property type="entry name" value="PTHR30272:SF8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00017810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE05256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="819" mass="90595" checksum="E206C084707AD81A" modified="2018-12-05" version="1">MELQSVVQRQLMQMLARNRALLLQAPHATGEAARETVATFAPPEPVVPERQTDRGFVLSPADSSLRAAVLLPDAAPVPVSALVDVTRTALSPELPSLAPPAVRFTREELEVLASGNISAVFGPAFAEQDGFARQVRMPEPPLLLADRVVQLYGEPLSMGLGSIQTETDVRPDSWYLHKGRMPFGIMIESGQADLLLISWLGIDRLNRGERVYRLLGCELTFHGSLPAPGETLRYDIRVDSHAKHGDIRLFFFQYDCRDDQGRRRMTMRHGQAGFFTDEELRESGGVIWDPAAAEVGPEARLDPPHVRSTKTSFVPEEVRAFADGDLYGCFGEGYAFAQTHTCSPSIQNGRMLLLDEVTAFAPDGGPLGRGYLRAETNLSGNEWFFAGHFKNDPAMPGTLMLEGCVQAMSFYLAGLGYTLRKDGWRFEPVPDMPYRMICRGQVTPASRKLRYEVFVQEVIDGAEPTVVADVLLTVDGLKAFHCSRLAVRLVADFPLHTDLRHLAAGASGDPRAASAEGVTFDYYSLLACAFGKPSHAFGSRYAAYDGGKHVPRLPGPPYHFMTRVTEAGGQLGVPKTGTVIEAEYDIPPDAWYFAENGSRTMPFCVLLEAALQPCGWLTSYLGIPESPEQDAYFRNLDGKATLHREIFPHAGTLRTRVILTSLSRMGHTYIESFHVECFVKDAPETPIFTMSTVFGHFTLADLSNQVGLGADAAELERLREPSDFDADLRSADTLIAGRPASAAKLANGKLRMIDRVTGHWSRGGKHGKGRSRAEKRVDTGDWFFKAHFYQDPCSRDRWASRRCSSFYSFICCKKRWTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPH0</accession>
    <name>A0A398CPH0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_18165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02608">
        <property type="protein sequence ID" value="RIE02608"/>
        <property type="gene ID" value="D3H35_18165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="124" mass="13023" checksum="5EF44FADD81C1FE3" modified="2018-12-05" version="1">MAAGRACSRGSGGRCREKWGQPSGKERDEWQPGCVTWSYGKSKNVGLCEGTVSYVQLKAAASGADIDGKKVKLDKQSLEDALGAPAFVADDGWGVTNGTDALKVFVDDSGNLVSLDLFEDCCGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPQ6</accession>
    <name>A0A398CPQ6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_18895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKC lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02718">
        <property type="protein sequence ID" value="RIE02718"/>
        <property type="gene ID" value="D3H35_18895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008844">
        <property type="entry name" value="Spore_GerAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038501">
        <property type="entry name" value="Spore_GerAC_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35789">
        <property type="entry name" value="PTHR35789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05504">
        <property type="entry name" value="Spore_GerAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="115" mass="13388" checksum="4DDF87519A17BC80" modified="2018-12-05" version="1">MRIDVRVSGDLILNTTNISSMSLPFMEKVKTAWASQLKEDTDAAIERIQKELAVDAFGFAEQFRRHFPHQWAKSKADWKEIFKRMPVDVRIYTRVVRIGKSDIPQGIPEDQVRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPV1</accession>
    <name>A0A398CPV1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 12">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">fabF</name>
        <name evidence="16" type="ORF">D3H35_07715</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12 14">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 12"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04462">
        <property type="protein sequence ID" value="RIE04462"/>
        <property type="gene ID" value="D3H35_07715"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 14 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="15">
        <location>
            <begin position="5"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RIE04462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="413" mass="43603" checksum="898F942E77706981" modified="2018-12-05" version="1">MTHRVVITGMGVVTSLGTDLNTFWDNILAGKSGVSLIEAFDTADYTTKIAAEVKNFSAESFGVDKKTTRKMDRFVQFGAAASLMAIKDSGLEIGVNSDPERVGVSVGSGIGGLGTWEDQHTILMEKGPRRVSPFFIPMMIANMASGQISMLTGAKGPNTATVTACATGTHSIGDSFKMIQRGDADAMICGGAEATIRPIGMAGFCSMRAMSTRNDEPEKASRPFDVDRDGFVMGEGSGVLILESLEHAQKRGARIYAEIIGYGMSGDAFDMVEPDPDGAARCMSRAIKDAGIAPEEIGYVNAHGTSTPVGDKSETTALKKTFGEYAYKLAVSSTKSMTGHLLGAAGGVEAVILALSLRDGILPPTINLDNQDPELDLDYVPNVPRKADVSIALSNSFGFGGHNATIIMRKYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ47</accession>
    <name>A0A398CQ47_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription attenuation protein MtrB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Trp RNA-binding attenuation protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Tryptophan RNA-binding attenuator protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mtrB</name>
        <name evidence="10" type="ORF">D3H35_03900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Oligomer of 11 identical subunits arranged in doughnut-like structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MtrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04643">
        <property type="protein sequence ID" value="RIE04643"/>
        <property type="gene ID" value="D3H35_03900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000824">
        <property type="entry name" value="MtrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023558">
        <property type="entry name" value="Trp_RNA-bd_attenuator_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02081">
        <property type="entry name" value="TrpBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00687">
        <property type="entry name" value="TRPRNAAP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TrpBP" evidence="9">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="74" mass="8245" checksum="9C00BB1263358F1E" modified="2018-12-05" version="1">MEEKTQAEYVVIKAKDNGVQVIGLTRGQDTKFHHTEKLDRGEVLIAQFTDHTSAIKIRGKATVLTKYGTVDTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ73</accession>
    <name>A0A398CQ73_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01581">
        <property type="protein sequence ID" value="RIE01581"/>
        <property type="gene ID" value="D3H35_24865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="220" mass="24260" checksum="3C43B34D0FF8DD8D" modified="2018-12-05" version="1">MKLVKTRISLSNKAVIRIGFLYLFTSLCILCSNMIDIWILDDDLLTNDSFPDILYTTFNLMGFFGLILGLFALFIIHHKDLGKLGYACYILAALGTMLYAGDAWFEAFVIPFLSDEMPGLKDIDPGISLMVGIVITFLTFSIGWITVGVSAFRVGLIPKWISSLIIIGGIFGFRALTPPYFVPLAIAVGAMGVWFLRSKSFTNNLAEISNDTGEVSMVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ87</accession>
    <name>A0A398CQ87_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfite exporter TauE/SafE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_12495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03469">
        <property type="protein sequence ID" value="RIE03469"/>
        <property type="gene ID" value="D3H35_12495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039447">
        <property type="entry name" value="UreH-like_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13386">
        <property type="entry name" value="DsbD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD_2" evidence="2">
        <location>
            <begin position="9"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="226" mass="23846" checksum="3487ECD667269B18" modified="2018-12-05" version="1">MMADSLTIAVVAGLTGAPHCIIMCGGIGSSIALEARKSAMLSVLAYHAGRIVTYSVSGAVMGSIGSFINAAGKLVGLQSIASIVGGAFILLWAFRKYAIPLPARKTKGSRITHEIAGRIRAPFELLSVFLTGLMLGLLPCGLTYSMQMRAAAAGSWIEGMATLLVFGLATVPVLLAVALTANRMGRRWRRGLRAAGFYVAVIMGLLSILKGFSVNGWIPSIHPWLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQE4</accession>
    <name>A0A398CQE4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2975 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_22730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01214">
        <property type="protein sequence ID" value="RIE01214"/>
        <property type="gene ID" value="D3H35_22730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021354">
        <property type="entry name" value="DUF2975"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11188">
        <property type="entry name" value="DUF2975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="160" mass="17845" checksum="FDCA44D7341B2EBE" modified="2018-12-05" version="1">MERGTTLFLKVSIFLIGIPIFALCLFLVPEIGNYAVELYPDAAYLKYLVFIDFYAAAIPFYFALYQAFKLLSYIDKNKAFSELSVRALKDIKYCAITVSTFYALGLPLFYLIAEAEDAPGIIVIGLVIIFTSIVIAVFAAVLQKLLKNAIDIKSENDLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQI8</accession>
    <name>A0A398CQI8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03529">
        <property type="protein sequence ID" value="RIE03529"/>
        <property type="gene ID" value="D3H35_10790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="80" mass="9264" checksum="695F1AC34E7104C4" modified="2018-12-05" version="1" fragment="single">PLNELSERLEEAGWTFCSYSVHQLNAFLKSQYEAGKLAREVVLTTEREDPITEMKYTVRYDIHLHRPFLASSPGVPALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQY6</accession>
    <name>A0A398CQY6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2627 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04570">
        <property type="protein sequence ID" value="RIE04570"/>
        <property type="gene ID" value="D3H35_05645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020138">
        <property type="entry name" value="Uncharacterised_YqzF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11118">
        <property type="entry name" value="DUF2627"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="129" mass="14347" checksum="2047BA829645A504" modified="2018-12-05" version="1">MKIIISRLIAVLLLVIPGIAAAYGFLLMKDAIFDYFADMGNVDLPNPDFAWATFVIGFIVFLIGVGFIGGWIFYRDRKHNYLSSRFRPKRPDPLGPAAAPNRLSPSQRKLSDAMKAGELSFVIRQGCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR21</accession>
    <name>A0A398CR21_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Malonate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="2">MSA dehydrogenase</shortName>
            <ecNumber evidence="2">1.2.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Methylmalonate semialdehyde dehydrogenase</fullName>
            <shortName evidence="2">MMSA dehydrogenase</shortName>
            <shortName evidence="2">MSDH</shortName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mmsA</name>
        <name evidence="2" type="synonym">iolA</name>
        <name evidence="5" type="ORF">D3H35_12750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) = H(+) + hydrogencarbonate + NADH + propanoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:20804"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>3-oxopropanoate + CoA + NAD(+) = acetyl-CoA + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:22992"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldehyde dehydrogenase family. IolA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="2"/>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000038">
        <property type="protein sequence ID" value="RIE03238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03238">
        <property type="protein sequence ID" value="RIE03238"/>
        <property type="gene ID" value="D3H35_12750"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00076">
        <property type="reaction ID" value="UER00148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018478">
        <property type="term" value="F:malonate-semialdehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102662">
        <property type="term" value="F:malonate-semialdehyde dehydrogenase (acetylating, NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01670">
        <property type="entry name" value="IolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023510">
        <property type="entry name" value="MSDH_GmP_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="PTHR43866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1 2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="16"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="177"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE03238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="486" mass="53332" checksum="B72B38B73F7E5443" modified="2018-12-05" version="1">MTTFFNEVQNYIGGVWASQQSENRIDVFNPATGDRLTTVPLSSKSELDAAVEAASAAFGMWSMTPVPRRARILFKYQQLLVEHWDELARLITLENGKTYKDAYGEVQRGIECVEFAAGAPNLMMGRQLPDIATDMESGMYRYPIGVVGGITPFNFPMMVPCWMFPIAIACGNTFVLKPSERTPLLANRLAELFTEAGLPDGVFNVVHGSHDVVNGLLEHPKVKAISFVGSQPVAEYVYTKAAAAGKRVQALAGAKNHTIVLEDADLDTAVKDIMAAAFGSAGERCMACAVVIGVGTIKDRLLEKLTEAADAIQIGNGMEEDVFLGPVIREEHKQRTLAYIQSGVEEGAKLVRDGRRDEACANKGYFVGPTIFSEVNSDMQIWKEEIFAPVLSYRTADSLDEAIAIANESEFANGACLFTHDARYVRRFRETIDAGMLGINVGVPAPMAFFPFSGWKKSFYGDLHANGTDGVEFYTRKKMVTARWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR98</accession>
    <name>A0A398CR98_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Diadenylate cyclase</fullName>
            <shortName evidence="10">DAC</shortName>
            <ecNumber evidence="10">2.7.7.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic-di-AMP synthase</fullName>
            <shortName evidence="10">c-di-AMP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dacA</name>
        <name evidence="12" type="ORF">D3H35_02670</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably a homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate cyclase family. DacA/CdaA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="10"/>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05052">
        <property type="protein sequence ID" value="RIE05052"/>
        <property type="gene ID" value="D3H35_02670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01499">
        <property type="entry name" value="DacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014046">
        <property type="entry name" value="C-di-AMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034701">
        <property type="entry name" value="CdaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045585">
        <property type="entry name" value="CdaA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19293">
        <property type="entry name" value="CdaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004793">
        <property type="entry name" value="UCP004793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00159">
        <property type="entry name" value="TIGR00159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="DAC" evidence="11">
        <location>
            <begin position="83"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE05052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="279" mass="31472" checksum="9A0BA17371682A69" modified="2018-12-05" version="1">MNYFSGLTWTTSIKDIADILIVSYLIYRMILLVRGTKAVQLIRGIFLLVLTWALSTWLNLYTLKWLMNQVFTFGVVTVLIIFQPELRRALEQLGRGKLFTRSSPEEQDVSHQIGEIMKAVNYMSQRKIGALIVFERNTGLNDYIESGIKMTSNLTSELLINVFIPNTPLHDGAVIIRANEIMAAGCYLPLSENPFISKELGTRHRAAIGISEVCDAISVVVSEETGQVTLAINGQIVRDIKEESLISKLFDELRPQLKAKVAEWSWRSLLRRKAGGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRB5</accession>
    <name>A0A398CRB5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DegT/DnrJ/EryC1/StrS family aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_02775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05072">
        <property type="protein sequence ID" value="RIE05072"/>
        <property type="gene ID" value="D3H35_02775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE05072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="445" mass="49022" checksum="54D7F0FDB1580DC3" modified="2018-12-05" version="1">MSDKENRLALFGGPKAVTDAPGDLFTWPIVTKEDEEAALEVLRRGAMSGTDVTMQFEADFRQWLEVDYALGFNNGTASLQAAMYGCGVGIGDEVICPSITYWASGAPAYSLGSTVVFADIDPVSLCLDPNDIEHRIGERTKAIVVVHYFGHPADMDPIMAIADKYKLKVIEDVSHAQGGIYKGRKLGTIGHVGAMSLMAGKSLAVGEAGMLVTNEREIYERALAFGHYERFNQEIQSEALKPYIGLPLGGAKHRMHQLSSAVGRVQLRHYEERQAEIRRAMNYFWDLLEGVPGLRAHRTAPGSDSLMGGWYAAHGHYRTEELGGLSVSRFCEAVRAEGVEDCVPGCNLPLHTHPLFKEADVYGHGRPTRVANSERDVRTLDADLPVSGGIAARVYAIPWFKHYRPQEIEQYALAFRKAALNYKELLEGDTGNPASMGGWNMFKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRC9</accession>
    <name>A0A398CRC9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cu_amine_oxidN1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_09710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03819">
        <property type="protein sequence ID" value="RIE03819"/>
        <property type="gene ID" value="D3H35_09710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901575">
        <property type="term" value="P:organic substance catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017450976" description="Cu_amine_oxidN1 domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN1" evidence="2">
        <location>
            <begin position="54"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="675" mass="74498" checksum="488C9831C73A9109" modified="2018-12-05" version="1">MSFIRKKMLALLAASLVLLGLPAAAFASGESSPVEVVLDGAKLQFDSPPVIKGGFTLVPIRKIVEAIGADVKWDPVGKTVLISKQGSTVQLKVGDKKAFVNGKAVTLDYEATVVNERTLIPLRFVSESFDVLVDWENATRTVYLTSLDSEPGGFDYSGVTLASVRDSNVTPSQEIKYDKLVLISGEGANEKKVFVKFDLSSFQGKKIKKAYLHMFSNETLETNSERTITVNKSLRDWTGGIDWRTYDGARNWDSPGAAGAGDEVKNIASQTVFRIIGWEPSWFIDVSPTVRAWADGTAPNYGLSLSFDRYFSMIGFPVSKLNPNLVPTLVIELDDYDAGNPSAAYSKKIKTGLDFIARKYHMLPWGDDSIGILNSQYNLGKLGFGDAYTANVRNYFDYFVDESGAFRRGAVPKASFYNGVFGSLLLDLYKDTGKENYLTAAKTIRASYDTLPRLNGLFTENDVIQAELTFLGLDFLARYGDRLADSASTDLAVTQAIALYDKLTALEKDGIPATIIFADGKTIGKGWGRGIGWYFGGFGKLFQYASVKSHPRYAELESRYKALALKIARYQDSSGLWRNIIQDPASAFETSGTSLIAIGYEYGVNAGVLDKKYAKVVDRAINGLQRYSKTGAEMSQAFPSNQDLVYTYTNYSNTRKSYGFWFELLTTRERNGRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRL7</accession>
    <name>A0A398CRL7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04800">
        <property type="protein sequence ID" value="RIE04800"/>
        <property type="gene ID" value="D3H35_04845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="59" mass="6474" checksum="777AE09FBFF5289C" modified="2018-12-05" version="1">MRSQTPSSVQTVTVAVTLSSISRLLPNGENPAEPSSKPSIFIIASGRTFVNHRKEEKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRM8</accession>
    <name>A0A398CRM8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01574">
        <property type="protein sequence ID" value="RIE01574"/>
        <property type="gene ID" value="D3H35_24825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="119" mass="14056" checksum="B9FAE98377B14D84" modified="2018-12-05" version="1">MQKNPVQCQFVAALDSIVGKWKPIILYHLLQGKPLRFNELRRLLPDITQRMLTLHLRELEEEEIVKRVIYPQIPPKVEYSITEYGMSLSPVLETLHQWGVAHIERKQLIKQKNEQTKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRT7</accession>
    <name>A0A398CRT7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02497">
        <property type="protein sequence ID" value="RIE02497"/>
        <property type="gene ID" value="D3H35_17550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="1">
        <location>
            <begin position="80"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="363" mass="39456" checksum="DB7112D36139EDFF" modified="2018-12-05" version="1">MDQKQNVLRLPSERLYQDELEALRAHDNEAKPAGWQLSPRAALTFITGGKVGGTTVTPKYIGNRRLVEMAIATLLTDRSLLLIGEPGTAKSWLSENLTAAIHGDSSKVIQGTAGTSEEHVRYSWNYAMLLAQGPSESALIKSPIYRAMETGGIARFEEISRCASEVQDALISILSEKTIAIPELGKEIAASKGFSVIATANTRDRGVNEMSAALKRRFNIIVLPSPSDLETEVNIVSRRVAEIASSYELKASLPAQEAVMKIVTIFRELRGGVTLDGKEKIKPPSGVISTAEAISLLTGSMALAGSFGTGTITEEDLAGGLQGAIVKDEEKDRLVWKEYLDNVMKKRGSEWRSLYNACREMND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRV7</accession>
    <name>A0A398CRV7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000013">
        <property type="protein sequence ID" value="RIE05302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05302">
        <property type="protein sequence ID" value="RIE05302"/>
        <property type="gene ID" value="D3H35_01325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="89" mass="9654" checksum="2668088F5CC9E2E9" modified="2018-12-05" version="1">MSLYRACGEAANGDFVRLSEAGQFLLPEKELCQVYDISRNSLRQALELLTNEGLLVKMVGGALWLRKISTSASMRATSSTSSALSILLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS83</accession>
    <name>A0A398CS83_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_10740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000035">
        <property type="protein sequence ID" value="RIE03608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03608">
        <property type="protein sequence ID" value="RIE03608"/>
        <property type="gene ID" value="D3H35_10740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="129" mass="14671" checksum="D95C62F0E58A9A92" modified="2018-12-05" version="1">MALSQAVNFFDWTFPSLPRRRTGDVLREHPLQDGTFEEVPTTVSDRNTIMLGDVALTQSIQLVPDLINFDLVKLVKVTLHYADEANGIDETKDFLFKKGAQEAKWELPTKTNPSKFTNGERLTSWSTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSB3</accession>
    <name>A0A398CSB3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_08305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04129">
        <property type="protein sequence ID" value="RIE04129"/>
        <property type="gene ID" value="D3H35_08305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="163"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE04129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="297" mass="32624" checksum="7B1550D15FA7EDD4" modified="2018-12-05" version="1">MKKQSGTVKIHSSGQAPADLNEGRHVVKARTIHNTDYVALDEVSKAVGYNGKWLKDGSYGIGDYDVAYKFRTGDSTAVMREKAVKLPAPAVKEGNRLFVPSAGLGDWLGKEAAFSVEPGQVSFFPKPTAKETGETGATLDFKDKLPKAEGKFRVKANADNQTDNPAYSLLEKAKKYIGVKYDFGAEPYSQSGKFDCSSFTNYLFSQYGVNLPRTADDQAQLGKSVSRDELQAGDLLFFYVPGRFKSNNKVGHVGIYMGDGNMIHSCPEPKDGVQITDINKPFWKETFLSAKRFDLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSI4</accession>
    <name>A0A398CSI4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA transferase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_02030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05170">
        <property type="protein sequence ID" value="RIE05170"/>
        <property type="gene ID" value="D3H35_02030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="299" mass="31970" checksum="B5BDC7C35C1AD0D4" modified="2018-12-05" version="1">MNGRDEDGAGKEDFRVKNRGFSSKFVSMEEAAKLVEDSAELAMTGHMEMSPMSFIRELIRSGKRSLKLVCVGSAAINADLLIGAGAVERVEYSQITLGEHGLAPHFRRAFETGRISGLEHACPTMAAALQAGASGIPFMPVRGLIGTDYMNVRDDFRAITNPFDEKETIAVVPALRPDVAVFHAFQADVDGNVLASSSQNNRLLAQAAKRTIVTVEEVVGRGELSLGSGSFIPSLYLSAVVHAPNGAYPTGCPGYYAQDAAYVRDYAAASKSEQAFESYLSKMVRDPGNRDAIGTAVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSW2</accession>
    <name>A0A398CSW2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02411">
        <property type="protein sequence ID" value="RIE02411"/>
        <property type="gene ID" value="D3H35_17035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="13"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="301" mass="34829" checksum="42A38BA161F0D063" modified="2018-12-05" version="1">MKDIHISTGDYSIIIIPDTQIVTKYHPEMLLPMTKWIVSQAERLNLKMVLHIGDVVDEGATNELQFQQSFAALQVIDQADIPLLICPGNHDYDNLLDQDRSLRMFNTYFGMERYKNKKWFSGVFEQGKVENCYAKLEINNQNYLFLSLEFGPRDEVLLWVDQILAEHADYEVIIITHSYMYINGQRTKPGDTYNPKLYSGAEGANDGEDMWQKCFRKHANISAIYSGHHVPEHVSSRTDLGNHNNLVFQSFQNWQEDKHGGEGRIRIAVHRMIEQKVDHYVFNPISASYETNPGYEVSYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTM5</accession>
    <name>A0A398CTM5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="8">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gpsA</name>
        <name evidence="17" type="ORF">D3H35_03815</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8 14">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 12">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04629">
        <property type="protein sequence ID" value="RIE04629"/>
        <property type="gene ID" value="D3H35_03815"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 8 14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_Gly3P_dh_N" evidence="15">
        <location>
            <begin position="8"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_Gly3P_dh_C" evidence="16">
        <location>
            <begin position="185"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="260"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RIE04629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="355" mass="37838" checksum="9D48C281FAAF535F" modified="2018-12-05" version="1">MEYEGKHVAVLVAGSWGTALARVLIDNGHSVKLWTRNAAQAEEINRDKRNSKFLPDAQLPEGMTATTDMAEALDGATMVLFVAPSSAMREVARQAVNHIGAETLIVHATKGFESESLKRMTTVLAEELGRAEDTIVVLSGPSHAEEVVNRQPTTVVVAARDIRSAEAAQDYFMNEGYFRVYTNPDVIGVETAGAIKNIIALGAGLSDGLGFGDNAKAALITRGLAEISRLGGAMGANALTYAGLAGVGDLIVTCTSRHSRNWRAGSMLAQGLPLDEVLLRMGMVVEGVRTTKAAHDLAARHDVVMPITEQLFAVLFEGKSPARAVEELMGRVRTHEIEETAVSSVESGRDSKSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTU9</accession>
    <name>A0A398CTU9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">proC</name>
        <name evidence="5" type="ORF">D3H35_04225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04699">
        <property type="protein sequence ID" value="RIE04699"/>
        <property type="gene ID" value="D3H35_04225"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="3">
        <location>
            <begin position="14"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="4">
        <location>
            <begin position="175"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="290" mass="30674" checksum="A9116F0F28FC32FD" modified="2018-12-05" version="1">MSAVTSSPLGNATIYFYGAGSMAEAIFRGLVEGKLTAPERITVSNRQNAERLRELESRYGVIGAGDDTAKQRGLKEADVVVLGMKPKDAAAAIRSLAPLLRPDQLIVSVIAGLPIATIEQLLGGKRPIARTMPNTSSTIGLGATGISFSDSVTSTHRELTLAMFDAVGMTSVVEEPLIEAVNGVSGSGPAYVYYLMEAMIQAGVELGLTPEAARDLTIQTVRGASEMVRLTGEDPAELRRKVTSPNGTTQAAIETLESFSFQEGMNKAIVRCAERARELGAAIREEASKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUI2</accession>
    <name>A0A398CUI2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02941">
        <property type="protein sequence ID" value="RIE02941"/>
        <property type="gene ID" value="D3H35_20255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="111" mass="11518" checksum="E5D70270BC06C3D0" modified="2018-12-05" version="1">MSVPLSSWVKAITFSSGASTVVPAGTVSLNFHIFVFGPVLSWASYLAFMPLLNSKYRPSADNPSLTIVSSVSCTVNGSSSPSFRVSPVGISGVMPLPVNVYCGGTASTITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUL8</accession>
    <name>A0A398CUL8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_03210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04959">
        <property type="protein sequence ID" value="RIE04959"/>
        <property type="gene ID" value="D3H35_03210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="106" mass="11477" checksum="BCDD23D0B71A7532" modified="2018-12-05" version="1">MRLLKYGKAAAEGRTWKLKPEVSFNYLGQFDQDVETGLFAGSRYGAGSSVSPNGERTSTLSINGMVLGGHLQLTIDYNGKGYEADTIESWQPGTSVIWKPSSSIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVQ3</accession>
    <name>A0A398CVQ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_03750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04618">
        <property type="protein sequence ID" value="RIE04618"/>
        <property type="gene ID" value="D3H35_03750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="113" mass="12243" checksum="BE496EF5C3824B86" modified="2018-12-05" version="1">MKLGSFIMGGLAGAALAVVVKRSPMLSAACAGIGRSLSERMSGMKEKAMNKTFDMSFSGGFKRWKGEEDEAKRSSHSETSSFDLEEISRLASKDSSVKSEINEILDQNGQHHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW41</accession>
    <name>A0A398CW41_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03234">
        <property type="protein sequence ID" value="RIE03234"/>
        <property type="gene ID" value="D3H35_21240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="17" mass="1781" checksum="8750B07F1F0BB1A2" modified="2018-12-05" version="1">MHCGDCGNVMGGRQTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW59</accession>
    <name>A0A398CW59_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NMT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_12845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000038">
        <property type="protein sequence ID" value="RIE03254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03254">
        <property type="protein sequence ID" value="RIE03254"/>
        <property type="gene ID" value="D3H35_12845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017268145" description="NMT1 domain-containing protein" evidence="2">
        <location>
            <begin position="40"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="3">
        <location>
            <begin position="75"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="144" mass="15021" checksum="B12269FBB06E7D45" modified="2018-12-05" version="1">MKKNDYHKQKWVLTTASVLLAATVASGCGSTKDDQPSDAAPSKSPAASGSSKPSAAGAKPLKQVTFSYSGGTCEAPIFVAYEKGFFKEEGLDVSLVQQDFETLKTGIATGKVDGTIGNFAWFKPIEQGFDVKLTAGCTRAASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW91</accession>
    <name>A0A398CW91_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_04940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04818">
        <property type="protein sequence ID" value="RIE04818"/>
        <property type="gene ID" value="D3H35_04940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="264" mass="29466" checksum="DB614CC87025F152" modified="2018-12-05" version="1">MHEHSDSTPRLAFHFSTVKLLSPDSMLAVPLGQGIMHKAPESEWVQLDEGLPDDTHVNRLQVYGEDIYACTNQGLFKREENWWTPGGLGAFCYQFKQVGRVSLAGTSNGLWCKDGNEWRALSCSGRVVYDFLYLPHFIVIGMDLGLSIYDRLAQAWMNFRLNVAVTSLIVSQGVIMGATEKGELLIGNRKGGFERYKFGSLFVFNVVNAGNESFACTDKGLYRISRFRNAPRLMAVKLGCQVTDVDSDGESLYIATLFQGVQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWN3</accession>
    <name>A0A398CWN3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prephenate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_00945</name>
        <name evidence="10" type="ORF">D3H35_03310</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000017">
        <property type="protein sequence ID" value="RIE04978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04978">
        <property type="protein sequence ID" value="RIE04978"/>
        <property type="gene ID" value="D3H35_03310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05384">
        <property type="protein sequence ID" value="RIE05384"/>
        <property type="gene ID" value="D3H35_00945"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="192"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE04978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE05384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="273" mass="30500" checksum="4F4C354915FD7208" modified="2018-12-05" version="1">MIRVAYLGPKGTFSEEAAHQFFSDQTIWVMYESILDVLEAVHNEEVDKCIVPIENSIAGNIHTTIDGLLMYDLHIEADLIFTVSLHLIGNQDSNMNTINTISSISPAINQCRDFIKKHSYKCEYTDSTSKAAQLVKDSNENNIAAIASKLVAFEHGLKILQSEIQDNSVNHTRFIVVGKGLVESAEQMKSMMLINPNNENPGVLSSILNVFSALGINLTWIESRPTGKRLGTYRFLIESEVAQNDQRMVKAIRILETFEHQVHIVGSYSTTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CX07</accession>
    <name>A0A398CX07_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_09290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03741">
        <property type="protein sequence ID" value="RIE03741"/>
        <property type="gene ID" value="D3H35_09290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="92" mass="11030" checksum="DA934FF4FAE04CF0" modified="2018-12-05" version="1">MFEGIDFSPGLVTYNETQNPNYLHEEDLFQVSYNEDMYVLDLGWYGNEFALMLIRQLDWSNPIWEKRTSDLLELEPLMRECVVYVKKLLMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXD4</accession>
    <name>A0A398CXD4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04427">
        <property type="protein sequence ID" value="RIE04427"/>
        <property type="gene ID" value="D3H35_07535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012544">
        <property type="entry name" value="PHb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037063">
        <property type="entry name" value="PHb_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08000">
        <property type="entry name" value="bPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="bPH_1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="125" mass="14179" checksum="0CA2141B3E7BA3E2" modified="2018-12-05" version="1">MGIFDGLLGNASEISPAEAQKDLANLLYESERVEKAYKLIRDLFVFTDKRLILIDKQGLTGRKVDYHSYPYKSISHFSIETSGHFDLDAELKFWISGNPTPVSKTFNKSLNIYELQAVLARHILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXL9</accession>
    <name>A0A398CXL9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_08405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03971">
        <property type="protein sequence ID" value="RIE03971"/>
        <property type="gene ID" value="D3H35_08405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="149" mass="15893" checksum="9B35819CAA5769E1" modified="2018-12-05" version="1">MFGFMLFLHLTGLAIWIGSMLAIVVTLSLLKKQLGSKEPNELAGRVIRAFSLFAHPSAVVVLGSGVYMIVKAWGGGSDRPLWLDVMEKGGGMVLLLALILTGILGGKVRKRLKDVQGQGSKVKLGFYLSSIAAFVTLAIAVVLVVSIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXM2</accession>
    <name>A0A398CXM2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000031">
        <property type="protein sequence ID" value="RIE03734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03734">
        <property type="protein sequence ID" value="RIE03734"/>
        <property type="gene ID" value="D3H35_10005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="68" mass="7844" checksum="7A312921F66AF295" modified="2018-12-05" version="1">MQDVLLQVAPVVLLDEFRIRFEHSAKLVGIETIRERNEQAVLNERFIAKSGKIDELHCPIAVVDRFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXN0</accession>
    <name>A0A398CXN0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">xerD</name>
        <name evidence="10" type="synonym">xerC</name>
        <name evidence="14" type="ORF">D3H35_05490</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family. XerD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04547">
        <property type="protein sequence ID" value="RIE04547"/>
        <property type="gene ID" value="D3H35_05490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011932">
        <property type="entry name" value="Recomb_XerD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02225">
        <property type="entry name" value="recomb_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0229">DNA integration</keyword>
    <keyword evidence="8 10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="13">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="12">
        <location>
            <begin position="106"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE04547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="298" mass="33839" checksum="72C9445CF1AD9BC5" modified="2018-12-05" version="1">MKKWLQAYSKRLEDERNRSAATVRSYVSDLNDFIAYAEEQGVKEVRELRSNHIQAYLSRLKQEGRKTATIARRVVSLKKWFRFLTIERAIEYDPTLQIESPKPERKAPLALKQTEMDRLLESIDPANRQGLRDRAMLELLYATGLRVSELIALNIDHVRLDMGFLTCTSPGGRERMVPVGSYAASWVERYAAEARPQLSREDKPEQALFLNVFGERMTRQGFWKTVKKAAGAAGIGAEITPHTLRHSFAAHLVENGADLRAVQEMLGHTASASTQIYQTPSGLKVKDVYDRAHPRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXQ0</accession>
    <name>A0A398CXQ0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Octanoyltransferase</fullName>
            <ecNumber evidence="6 7">2.3.1.181</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lipoate-protein ligase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoyl/octanoyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">lipB</name>
        <name evidence="12" type="ORF">D3H35_05620</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6 7">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the LipB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="6 7"/>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04567">
        <property type="protein sequence ID" value="RIE04567"/>
        <property type="gene ID" value="D3H35_05620"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="11">
        <location>
            <begin position="33"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="78"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="145"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 9">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6 8">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="6 10">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE04567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="234" mass="26314" checksum="9D41F7728CFD36C6" modified="2018-12-05" version="1">MLSKPLNISYLSRMDYGEAWDLQKKLVREIDREERDDSLLLLEHSPTYTIGSDRHPEHLLLSPEELNKRGIALFEIDRGGDITYHGPGQLVGYPLLYLDAVGLDLHKYLRDLEEAIIGLLAEFGISGGRKPEYTGVWVGDAKIAAIGVKFNKARTRRGFVTSHGFALNVKRCVKEDGFKGIIPCGIQEYDVISLEDLTGLELDVEQIGRRIIPHFGRVFGYESDEAIRTASLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYL7</accession>
    <name>A0A398CYL7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04321">
        <property type="protein sequence ID" value="RIE04321"/>
        <property type="gene ID" value="D3H35_06880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1807"/>
            <end position="1873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="2034" mass="221501" checksum="9BD6CAB8145F16A2" modified="2018-12-05" version="1">MNYAAIRTKLGQAGDHFTLEIPELTSSELQKALITYMPESKIGLHSIQVLQSDEQKIRVQGTGMTVPWTGMTVELAITPDEETEVALHIHAAGQPGWTFADSFPSLAATMFANIPFASTSVLEWSLREGITFEGSVEPEKALGAFAFLAPVLPLSFKGKIEAHSGVPKLALASQASASSIELGPFKLSNLTCTIGTDVSYFQTMQDLYAEGYIQLHADVQLGTLPLGLTAKIKNLYHSVLFVIEAPKLISTSLDALSSLLGNVSLDIPAEWVQDVKAIRLDRIEMLVNPLGDTKIERLVVEVDVDKQLDLLPNVLSFDGLQTVFIIDDPLTAPQLSGYITSDVVVGNSGIFTCRCDFGELSFLVYLESGSYIAFHQLFEKLTGYDDPSLPLLTLTGFTADFHPREGEFTSEVMFGDIWEVPFVPGLGIGELFGRIARKQGELSFEVSGVLAIADVPIQLSASYGGEEAGWVFAGETSDIELPIGSFVDEVLKQAGDFSLPSTLAGLTLTGIGVRYELSYEELTFHCETRFPIAGKPVDVRIDFDLSYDGNVTCHLHIYGKGDILLFGGVSLQKLDFALGVEQAQHSWNVGGELGFGLAGTSVTLAAEVHSEKNGGWSFGGSLAEGSALRLSDVAKALLPDGATMPQELPDLELSDVSLSVTPSTGAFSLSGECKAKWDMPLGLATGLAVGSVKLNIERTASRKSGEDGSEGSSEEGNAVKGGAITCTLELHGEGPVAIVDGFIFKSADLKFELDQDHNWTLSGAIAGKLFETDYTLSASLETTEEARIFTFKAAFADLDKLLHLDGVGSLDIRELSVTINQQLKADAKSQATDESGTKAVQLQEGSPYTWSVEAKGRILFELLVQADIAGSLRLFQEKNKAGLVFQAEHAELALPLPIPDQNIAAHLALGSLVIIRQTKTDGESRWGFEGSASVWCTGLPSVMQAILADKVTGSLKIDDQGIQVSVDRLLKPIPIKIPDIDLGGLQLQLGTGVLDASNLAIGLRGSALSLSFDFGFGIPSELNSVLGKDAEGHPLIKLFRTYQESNPDSIIKLRLALDTEKGLSIRLLTSPFEAVTFYTEGSDTWCKISLGQDGDFGEFKFLVPSFSFDGASFSAKGGFQQVKPLRLPLKMIKGFLEGNGLGAATAILPDYLEFKELNFFDDNNHLMVTEFVHTLEQLGGFQFPQEFVDAMKIINDQLDQLPDQFKNYFKIGLPDGFRFDISVTGDGGVRIKISVDGDRPLKFIIPQPEGLIGVELHSLTFGEALGGAVFLLDMDIRIDMFDFITLATTLLLPPQVFDVLPNPRTLQKRIVIKKLFMLIIYQTQVPIPVPLFYDEIGIEYLGIEGVEFRFSLRFPKPKINFKDAAKMFTSFYSFFTKPEYLLKADEPPKEMDLRLTMGPSYVQLPKYFNNDLVLGTKADAFSISAYTSIAHVLNTLKTMSLNELIQAIPMDIRVGHQDISFGAMSMNVAWLLTTPQEFRDGAYTHIASSDSESQSMLQVLPPSPSANEQGLVLFLKGDWSLDGLGSLQSSFGLVGTSSGFATGMRAAGRLSNLLDVELKGDVIINPKSPANTFSLQGHSHLRLHDAEVFRGDLTINDKLFHIDGQLDLIPGSELIRMTGRLIGRISKEEFYLFGDASIQLGSYFTLARATAELTPTTAKLAGTWFGQTLMFVSQLSPDSWRFTATMSEFSIGDLVRITGAGNDPQPIASIQINADKSVELYVSGQVKLFGLVSETQLYVRQDGMHFSTRGSLFNLFQASLTAHATSTDLSNADFFVTGEYEQQFSEQLKAQVTEALQVASSHATAAISAEQAKVDAAIREVQRLDELVEATKQEIDRQQNEARRGFDQAVADLQNAQNEVNRLQYEIDMRQDRIRNLQWYEYILAPFIGIEIAGIEIARGTAMGALLVSQGVLETARSAISVYPVDLDPRVTSIVAAKVIAETTLQGANLVLEGVKQTVGTGIQVANYLAQAAIDTLFIVKRVRFSAYASHVTGSQMTLLLDISFMGNDQSFDFLFDFNNIPQSVKNMADKFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CYX9</accession>
    <name>A0A398CYX9_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_02615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05047">
        <property type="protein sequence ID" value="RIE05047"/>
        <property type="gene ID" value="D3H35_02615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="99" mass="10905" checksum="3A05C556402F8A68" modified="2018-12-05" version="1">MADFIVELPVLDASKAEKHLKAHIEFLDRLRESGVVLANGRFADGSGGLVIYRGESRESVQELVERDPFVANGVRSYIIREWLAKWGAGPSAARDLSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ79</accession>
    <name>A0A398CZ79_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_01955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05157">
        <property type="protein sequence ID" value="RIE05157"/>
        <property type="gene ID" value="D3H35_01955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="88"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE05157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="316" mass="35882" checksum="1B682E720F2DB979" modified="2018-12-05" version="1">MSEAAVTAGTGAGRTKPKWSRTFWRYRWLYFFMLPGIIYYIVYHYVPMFGLVVAFQDYNLMKGISGSPWVGLDNFREVFNSPDFPVLMKNTVLISLYRIVFNMLPDLLLALMLNEIRVRWFKKTIQTLTYGPHFISWIIVYGIMFSFFAPGSGLVTTFFRDMGWGSVDVLTNSDLFRSLLVSTDIWKSTGYGAIIYLAALAGINGEQYEAAAMDGAGRWRQLWHVTLPGVRDVFMLLVILRLGSILDAGFEQVYIFLNVRVYDTGDILDTWIFRRGIEQMDFSVPAAVGVFKSVIGFTLVLGANKLAKRFGGSGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZC5</accession>
    <name>A0A398CZC5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_01415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05207">
        <property type="protein sequence ID" value="RIE05207"/>
        <property type="gene ID" value="D3H35_01415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="645" mass="72802" checksum="2B46622566469381" modified="2018-12-05" version="1">MTNNPFIKPETAKLALTHIPPLIANTLLEKKEFTNEYGITLNAVLSVDNIKFAIQRSTLYNAIRNSTSNGTIVEDDNGGRWNLLSITTDGKSRGFKLTDGHQEIVFPELFSLSPDRSVRLHNINEIAKEINMSSAELEKWQTVLDNRALYDDEVELLNKYIQETPIKLAQSIRRRFLRGSVTKELLVPTSFDYYSRLVGTYDDASSVNEYAIGNCREFIKQLSSWHPYDGLMFSLFLSSHLSLTSEIDVDHLSNEELVRAYDFLDKNGDRLSQIGAIEIGLRIFTTRPEIEQHLIRLIEQIRDDDSGASDSRFKLLSTLFMFVDSELIASRLFTSKPPFYRRLAALAQAALISRQLISVKINISSFCEWLANNLDETYYLQTLIDMRSEPRWYPELAEDVHLKANYLGRIITAALNFTQDIKDSKLYDLILGSHPDSLSKFTTSLDVFFPGPLEGGEETPNALPLEISKAIDTQLSSEVTTLSSFIALVNSALIFRIGIDQSELAAKALKLGSYRLANVQEKSQLLTILNGLATVAAISRSCALADDLRIVVRRYMHDAQFALSIEESMRIFLISASSREDPRQWRTFLGDCLNELAFGELRGKDGELLYSYLQSLCGLVPELWISCSRAEAALVAFNTRSQSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D154</accession>
    <name>A0A398D154_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05221">
        <property type="protein sequence ID" value="RIE05221"/>
        <property type="gene ID" value="D3H35_01490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="239" mass="27609" checksum="848114A60A795836" modified="2018-12-05" version="1">MSEEMDILDHMIESIQSGTYEPDDKLPSENEFAERFKVPRMTVRKAYLRLQELGYAYSMQGKGNFVKDRHQRIPLALSSRESFSRKMKDLGFDYESRNLFCDQIETNNKIYEALGAEEGGRVFRVGRLRLIDKQPIALHISYVSESLFPDIGTVGREITSMYEFYESRGYHTFRYTQSLLSVTFPSKYERELFACAGVNPLLVLESEHIDDVSGNTLEYSKIMYREIFSPMSYEGVGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CBT0</accession>
    <name>A0A398CBT0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_29810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00233">
        <property type="protein sequence ID" value="RIE00233"/>
        <property type="gene ID" value="D3H35_29810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="227" mass="25414" checksum="055058C6C87BBD62" modified="2018-12-05" version="1">MNLFRMTSLIEGIDRMEEFLENNFVCMGWKGIGDLENVGAEELHTSLAGLTEACERSDRERGMLQAEISAFVHTMRDGDYVLVPAGDVVHLGDLGDYYYVEETDSEHHGTVHRRGVTWLNEIAKAELNEEVREWLDGPGEIAIFDRPAAETGLAHWIDHPFGAAHKLPRPEAGDSRTSAQPHATMPRSEKVDPQLVAEALDILKLALRSEDPERRERAAIAILNYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CCX0</accession>
    <name>A0A398CCX0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetraprenyl-beta-curcumene synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00560">
        <property type="protein sequence ID" value="RIE00560"/>
        <property type="gene ID" value="D3H35_27880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019712">
        <property type="entry name" value="YtpB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10776">
        <property type="entry name" value="DUF2600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="358" mass="40926" checksum="FBEAA4F22A3A1805" modified="2018-12-05" version="1">MNHSLLAGRSPRGPVSLMKRVYKYILPEVRSELASWRKVAETIPDAELRKQALDSMNAKQFHCEGGGVYAAANLERRDILIPLIVALQTISDYLDNLCDRSTSLDPEDFRLLHRSMLDAVTPEAPLGDYYAFRDEKDDGGYLHALVRKCQTCVSALPSYSLVQRHVRVMVSLYGDLQVYKHIDRSKREDELLAWWDKHAGSYPELRWNEFAAATGSTLGMFMLFLAASDEKLDARQADLIRDAYFPSICGLHILLDYLIDQAEDESGGDLNFCSYYAGQDDLNERMDRMVKAARKSADELPFSSFHRMIVEGLIALYLSDPKVKGQRSVRETARVLMRGSPWTRLFFWLNSHWIRKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CD07</accession>
    <name>A0A398CD07_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_21825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01066">
        <property type="protein sequence ID" value="RIE01066"/>
        <property type="gene ID" value="D3H35_21825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="91" mass="9839" checksum="A6F968ABEE9ECFC9" modified="2018-12-05" version="1">MDGSRIVVWTFSGYYHHHLIHHSVDREGGVFIPRVGRNEMDLALADRIQRAPSGGMLDSKPSGASLRVGQTSSSTRSGFSRSIAARSVGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDN7</accession>
    <name>A0A398CDN7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_27790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00545">
        <property type="protein sequence ID" value="RIE00545"/>
        <property type="gene ID" value="D3H35_27790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="82" mass="9710" checksum="23E0004ED252DC2B" modified="2018-12-05" version="1">MRKPRSSRKKSRSSAWFKPEAANRQIDAIRARIHLVESVMKQEQTAFLELQEQKRIFGDRLSLQLEEALSEERRLLESWGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDT3</accession>
    <name>A0A398CDT3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-deoxy-D-xylulose-5-phosphate reductoisomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_25915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000044">
        <property type="protein sequence ID" value="RIE00873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00873">
        <property type="protein sequence ID" value="RIE00873"/>
        <property type="gene ID" value="D3H35_25915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="1">
        <location>
            <begin position="4"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="153" mass="15624" checksum="1B659ECF1A069E4A" modified="2018-12-05" version="1" fragment="single">MKKVSVLGSTGSIGTQTLDVISRDPDSYEVVGLAAGSNIELLLEQARAFKPKLVSIATKELAERIRGELPPGVRVVYGEDGLNEVAAGVGADYVACALVGSLGLTSTLAAIEAGATIGLANKETLVTAGHIVMKRAADKGVAIVPVDSEHSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CEB4</accession>
    <name>A0A398CEB4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_25765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000042">
        <property type="protein sequence ID" value="RIE00970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00970">
        <property type="protein sequence ID" value="RIE00970"/>
        <property type="gene ID" value="D3H35_25765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE00970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="141" mass="16134" checksum="014F40DB1B6AB29B" modified="2018-12-05" version="1">MIVCRMENYLWWLSVGDCMLFLLHPELLAWEQSMLNQRNFFEWIGNVNTFDLPVPCYSAGRRQLREGQHAIVMATDGFLDSEGCDVNVMKDWPLRLSGSARELERGVLAFLSRLHAARTKDSTTLLVWPVNNPHPGVMPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF72</accession>
    <name>A0A398CF72_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_21720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01055">
        <property type="protein sequence ID" value="RIE01055"/>
        <property type="gene ID" value="D3H35_21720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="73" mass="8683" checksum="770B8CE18C456EEA" modified="2018-12-05" version="1">MRIRKTSLRRSQKNRRWSAVRRHLAWMTLFGLGLRGGRGYVLLRYEWRAARRLRAAAERKLLGRGRRGHPKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF98</accession>
    <name>A0A398CF98_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_27890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000052">
        <property type="protein sequence ID" value="RIE00562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00562">
        <property type="protein sequence ID" value="RIE00562"/>
        <property type="gene ID" value="D3H35_27890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="2"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="4">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="154" mass="16984" checksum="FB436B6FD7B5104A" modified="2018-12-05" version="1">MLAVGDIAPVFAAESTKGRIQLKHLIEQGPVVLIFYPKDFTPGCTKQLCAVRDSSREYKELGATVIGVNSGSLDEHQAFADLHGYDFPIVFDENERIRKAYGVGKFLGLFLQQRTVFIVGSDGIIAYAEKGLRPTSEVVGVLTRFIPPPIDYHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFL3</accession>
    <name>A0A398CFL3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_24475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01513">
        <property type="protein sequence ID" value="RIE01513"/>
        <property type="gene ID" value="D3H35_24475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009303">
        <property type="entry name" value="DUF960"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06124">
        <property type="entry name" value="DUF960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="104" mass="12192" checksum="8BFE58EC2D9C4EF8" modified="2018-12-05" version="1">MFPKHARYVTSRANDMIGPELQVILWSLIDRDLDEGQELDYLQVFTLSIVHDSDRIYQRIRQKQEQPKRKKLHEISGIIEPVSGVTVWIIDSGDYCTMLLPDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFP9</accession>
    <name>A0A398CFP9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4-amino-4-deoxychorismate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01330">
        <property type="protein sequence ID" value="RIE01330"/>
        <property type="gene ID" value="D3H35_23435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="294" mass="32283" checksum="3AA69AA001D63895" modified="2018-12-05" version="1">MIVLLNGQRTGSKEAVISVFDHGFLYGMGLFETFRTYGGKAWLLDRHARRLAESCEAIGITYRPDVAAMEKQISALLEANELADGYIRWSVSAGEGIIGLPTDPYDAPAEIVYAKPLAADRPDTRAGKPLRLLRTPRSTPENGALRLKSFHYMNNMVAKRELSASDAPPGAEGLFLDYRGYLCEGLVSNIFWVSGGTLHTPSLETGPLPGITRKFVIELAGRLGMDVLEGLYRWDELYRADEAFLTNSIQEIVPVTALDGGGSGNEQPIRSLAVGRATARLMREYRMAAEEGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CFS4</accession>
    <name>A0A398CFS4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_24820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01573">
        <property type="protein sequence ID" value="RIE01573"/>
        <property type="gene ID" value="D3H35_24820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE01573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="233" mass="26617" checksum="662CE939B08B305C" modified="2018-12-05" version="1">MGTVKKQERSTLANDVSKYLKQYIIDNNIGPGQKLPSERELSNTLQVSRQILREGLRSLESTGIISIRHGDGAIVQSHNLTPLLEQLMFLWKMDNKKISQLLDLRQIFELAAVDKIIANATEADFQMLRDLTLQMAQPAADTKAIQEADIEFHRALITATHNEMFMQLTDLIIEYFSKVSHYDMGPFSVEQWVQNHLSIVDALEKKDEILAKQVLRDHLDNSRQYLIDIDGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG32</accession>
    <name>A0A398CG32_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF327 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01415">
        <property type="protein sequence ID" value="RIE01415"/>
        <property type="gene ID" value="D3H35_23900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005585">
        <property type="entry name" value="DUF327"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024042">
        <property type="entry name" value="TM1646-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03885">
        <property type="entry name" value="DUF327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158397">
        <property type="entry name" value="SSF158397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="147" mass="17203" checksum="3E685E33F23397A6" modified="2018-12-05" version="1">MKIQPGYFPLGKTLQRGETSSRPAPAQNFGDFMHQNDEQRSNEELQRKLEDIRMQGDRLARSMTVRELKLYRNMVKSFLEDTVRRGVGLKETRGWDRRGRGKRYKLLEEVDEMLVAMGEELLQTEEGRIDLLNKVGEIRGILINFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG34</accession>
    <name>A0A398CG34_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS3 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_00915</name>
        <name evidence="2" type="ORF">D3H35_23695</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01683">
        <property type="protein sequence ID" value="RIE01683"/>
        <property type="gene ID" value="D3H35_23695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05401">
        <property type="protein sequence ID" value="RIE05401"/>
        <property type="gene ID" value="D3H35_00915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="195"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE05401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="355" mass="41089" checksum="43EE8F77C685D47B" modified="2018-12-05" version="1">MVQLYESGKSRASLVKEYDLTASALDRWISQSQRTGSFAAKDNRTPEENEMLELRKENQRLKMENDIFKASRADYGTKVNVIRNNAHKYSVSAMCSVLQLPRSTYYYEPVPSPDPQEQQLEEVVIEIFKSSRNNYGTRKIKVELARKSLQVSRRKIGRVMKRHGLVSTYTVAQYKPHKAAPNEAEIGNALQREFSQEKPLAVVVSDLTYVRVDAKWNYVCLFVDLFNREIIGHSCGVNKTAQLVYDAIASVSVRLDRIQMFHTDRGSEFDNKLISEALETFEIERSLSNKGCPYDNAVAEATFKIFKTEFVKQRHFHNLQQLQLELDDYVHWFNHHRIHGTLGYRTPVEARQWPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CG35</accession>
    <name>A0A398CG35_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_15655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02176">
        <property type="protein sequence ID" value="RIE02176"/>
        <property type="gene ID" value="D3H35_15655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="144" mass="15497" checksum="46EDF094C0C632D1" modified="2018-12-05" version="1">MISVTIPARSRDVGVDMMVSVTIPARSRDVGEDVLISVTIPARSRDVGEDVLISVAIPARSRDVGGVAMNIVTIPARSRNVGEDVLISVTIPARSWDVGGDVMNSVTIPARSRGFGGDTIIVAVCWRLHHRNRVVSCWQAVPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CGE0</accession>
    <name>A0A398CGE0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_24545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01525">
        <property type="protein sequence ID" value="RIE01525"/>
        <property type="gene ID" value="D3H35_24545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="213" mass="24962" checksum="5C065CD42C24D5BA" modified="2018-12-05" version="1">MAQFNARYLFKLKFKSPSSEALNTDFNTLISDVNEAIDAFNARFRGIKEIVLPSIEYSVISLVLIVYDEIREQITAKELTYFSRYLHNERDWVRFTKERTKLFVPIKINEITDAELFRHIHENSLNPLDYEEYFKNLELEEEYFDEELDRGNKGMEKGESFESDLISSVSDEQIIATLQSLLLNKDMGLAVNVFKKNAAVEKIKRILMPWIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CH61</accession>
    <name>A0A398CH61_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01805">
        <property type="protein sequence ID" value="RIE01805"/>
        <property type="gene ID" value="D3H35_13500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="242" mass="26454" checksum="F3263296AB882C36" modified="2018-12-05" version="1">MRTSGHTVLITGGSAGIGLALSKRFAASGNRVIAVGRDSRKLLWLKEALPQVETIACDLGDGIQRERLIHTLKEQYPDLSIIVNNAGIQYNYSFLEEKEPRIAEEIAINLTAPIELCSGLLPLLKTKEEAAIVNISSGLGLVPKTSGAVYCASKAGLHLFSKALRHQLEGTNVRVFEVLPPVIDTDMTRGRGRNKLSPDRLVDEFMPAFAGNRFEIAIGKVKLLRWLVRIAPGAADRLFKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHF1</accession>
    <name>A0A398CHF1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_28325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00338">
        <property type="protein sequence ID" value="RIE00338"/>
        <property type="gene ID" value="D3H35_28325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="82"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="305" mass="34375" checksum="A0E479E133C66B60" modified="2018-12-05" version="1">MSHTRVKTRNFQQVTPAWNAALNVVAALFAFVCVFPFLFVLIISFTDENSLATNGYRIIPKQWSVEAYRYLFETGGSLLRSYGVTIFVTVVGTVISLAIITLYAYAIFQKSFKYRRFFSFLAIFTMLFNGGMVPTFIIVTQLLHLKDTVWALILPLAVNAFYIMIMRTFFSTMIPTAILESGKIDGAGEFQTFYKLVLPLALPGLATIALFSTLGYWNDWFNALLYIDKPGLVPLQSMLMRIETSMQFIMQNSANTSLNTGILQKMPQDTSRMAMVVLATGPIVLAYPFFQRYFVQGLTIGAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHS5</accession>
    <name>A0A398CHS5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">EamA family transporter RarD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rarD</name>
        <name evidence="10" type="ORF">D3H35_27350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EamA transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00679">
        <property type="protein sequence ID" value="RIE00679"/>
        <property type="gene ID" value="D3H35_27350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004626">
        <property type="entry name" value="RarD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF114">
        <property type="entry name" value="PTHR22911:SF114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00688">
        <property type="entry name" value="rarD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="9">
        <location>
            <begin position="4"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE00679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="296" mass="32607" checksum="3CA76B18C224D7E7" modified="2018-12-05" version="1">MKQGLIYAILAYTAWGLLPLYWKWFEEVPAGEILSHRVVWSFVLMAVVLLIQRKWKAFREILADGRKMLTLGISGILISANWLIFIWAVNNGHVIETSLGYYLNPLMNVVMAVLFLREKPNRWQWAAVALAGLGVLTVAIDYGRIPWISLSLALSFSLYGLVKKKASFDASIGLLGETAFVFPIALVYLIGLQANGQEAAWSLPPEMLALLLLSGLATAMPLIWFAKAAARLPFSMLGFIQYIGPSISLLLSVWVFREPFSPVLLASFSLIWAALVVFMAASARGSGKMAAKPANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CHT3</accession>
    <name>A0A398CHT3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-layer homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_27305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000049">
        <property type="protein sequence ID" value="RIE00689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00689">
        <property type="protein sequence ID" value="RIE00689"/>
        <property type="gene ID" value="D3H35_27305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="430"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="490"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="SLH" evidence="1">
        <location>
            <begin position="561"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE00689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="620" mass="65122" checksum="18FFE6C6125E7671" modified="2018-12-05" version="1">MTVAATASDSGTISYQWYSNTSDSNSGGTPISGADSATYAAPTDTAGTFYYYAVVKNTNNAATGTKTATVTSNAVAVAVTIAPTYSIAAIANQTATPLQQGYAAGTQQTKTITVTNTGTGNLGHMSAALSGAHSNAFELTQPSATVNSLSSSTFTIRAKNGLAPGTYTVTVTISADFMTNVTFTVTQVVSRTYVPESPQNPEVSASVDVLVNGKAENAGKATTTTVNNQQVTTIAIDPQKLDEKLAAEGQHAVVTIPVGIDSDVIVGELNGQMIKNMEGKEATLELKVDRATYTLPAQQINIDALSAQLGESIALQDIKVRIEIASPTAGTVKTVEDAANKGKFALVAPSVDFTVKAAYGNKSVEVTSFNLYVERTIAIPDGVDPNKITTGIVVDPDGTVRHVPTKIVIIDGKYYAKISSLTNSTYSIVWHPLEFKDVANHWSKAAVNDMGSRMVISGVGNDLFNPDQDITRAEFAAIIVRGLGLKLEKGNSPFADVKAADWYSSAIQTAYSYGLINGFDDGTFRPLDKVTREQAMLIIAKAMKITALTDKLPSQDATALLNLFADGSSVSKWAVSGIADSVQAGIFKGRSGAQLAPKANITRAEVAVVVQQLLQKSDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIG2</accession>
    <name>A0A398CIG2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1292 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_21065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0473 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03076">
        <property type="protein sequence ID" value="RIE03076"/>
        <property type="gene ID" value="D3H35_21065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009711">
        <property type="entry name" value="UPF0473"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06949">
        <property type="entry name" value="DUF1292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="114" mass="12530" checksum="4C5A0C27577E504F" modified="2018-12-05" version="1">MGNRRRNVQYADGGIRRGEGGVSSLKQQYGDSVELTANGGKPQAYRILAEIAAGDREYAILQSEAMAKDGDIEVFRIVRGADGEADLETVEDDEEWERAAEAYDDLQFGSDEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CIQ6</accession>
    <name>A0A398CIQ6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_16165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02265">
        <property type="protein sequence ID" value="RIE02265"/>
        <property type="gene ID" value="D3H35_16165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="194" mass="20865" checksum="1D152980FE7B8E94" modified="2018-12-05" version="1">MAYSRMAWGLALELIDFRLGTFDLLPDVIGYGLLVLGLSGAGSASRPFAIGRMAAIALMLWSLPRFVGLQPSLSLLSYDTFGAAPLLLASAEAMLELAMLYGICEGIRLFAIVRENRVLARSARNGWRAVFGFSAAFLFLLPFKLNVTSVWLTAVVVLLVIGLFIACARVIFLVRRAGHVLNDGDGGPRKSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ15</accession>
    <name>A0A398CJ15_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DHA2 family efflux MFS transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_18980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. EmrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02733">
        <property type="protein sequence ID" value="RIE02733"/>
        <property type="gene ID" value="D3H35_18980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017364192" evidence="9">
        <location>
            <begin position="27"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="10">
        <location>
            <begin position="1"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE02733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="476" mass="51349" checksum="9A750946052F6A08" modified="2018-12-05" version="1">MAALMIAAFVALLSQTLLNVALPVMMKDLNVNENTIQWLSNGYMLVNGVLVPVSAFLIARFTTRKLFLVATSLFAIGTIICALSYNFGFLMTGRLVQAAGAGILMPLMSIVTLTIFPVSERGKAMGLMGIAMIFAPAVGPTLSGWVVEHHSWRVLFYIVLPLAIISLIFGAFSMKNVTKTSSPKLDTLGVIFSTIGFGGLLYGFSDAGSAGWDSPVVITCLVVGTLSLVLFIWRELVADKPLLEFRVFKYSMFSLTTGINAIITMAMFSGMILLPIYLQNIRGFTPVESGLLLLPGAILMGIMSPITGIIFDKIGARWLSVVGLIITTVTTFEFSRLTVDTTYSFLIVMYTLRMFGMSLLMMPIQTAGLNQLPQRLNAHGSAMSQTLRNVAGALGTALLVTLMTNKAASHGKELAIAGQVDPADKAKMAEIAQQATVYGINHAFVVATWMTVGALVLAFFIKKTKPQEEPQKEKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ40</accession>
    <name>A0A398CJ40_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2515 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_19165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02763">
        <property type="protein sequence ID" value="RIE02763"/>
        <property type="gene ID" value="D3H35_19165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019658">
        <property type="entry name" value="DUF2515"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10720">
        <property type="entry name" value="DUF2515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="403" mass="46154" checksum="7A0D9C0A68878788" modified="2018-12-05" version="1">MNEKKRKTDRVNALMRVTGRLAAGMWNGFRGWYDSIRLTRNRSEMRLSHSAMMELREALDGQRSPSDQRRGCDGCLDLVERITSETTALNRNNLTRTQAYWDIYQAHPELHWALLAHLVSRNGGWSMTDLKGQWLPKLLPADQLRWSFDMLESCNSLIFGDAYPQLRLYAESKRQGIGLFRLLPSFGVSVFMQPCWERFWTERNSVLISTALIVNEQHYIQSRVVENEVFRKRVFDNAAFQSQPLLQLNQIVFPLKLGTRSVSLAGRILERFESLEERIEFGKCLYAMLFGYPTVLRGAAAFAKEVAHTGSRADYWPHVFADKQKTGATAGLSKGWYSPCLSAAWPDKPLIAASRGDWYSNREAFAYLEKLPLPRIIAMSREHMHGQRKLQAAALALGGRYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJ77</accession>
    <name>A0A398CJ77_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylglucosamine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01279">
        <property type="protein sequence ID" value="RIE01279"/>
        <property type="gene ID" value="D3H35_23115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="1">
        <location>
            <begin position="9"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="335" mass="37042" checksum="9A0B408108F80F6D" modified="2018-12-05" version="1">MRLSNQRFIGLDGGGSKTYCVIGDGEGRLTFLSRGSSSNMKSKPWTEVRKVLSESIMECWDNGREEESELNTVFLGMAGSDRPEDRERIGCFLEELLPSNREFVVRSDALSAMASGTWGEPGIILIAGTGSIATSYNPATDEYHRVGGWGYVLGDEGSGYQIGRSGLISMLHQFDGRGPYTAITEKVLRQWKMDNASQLITYVYENEELRKTVAEAARAVLDSAAEGDQVANRIIDEAIGELILLVETLAGKGSRREERSPLVIAGGLFDSETFFSRFRERAAERLAGFDPVRPEFPPVIGSYILALRRADIAITLQVRQRLAESWNALRGQIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CJT0</accession>
    <name>A0A398CJT0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_20315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02953">
        <property type="protein sequence ID" value="RIE02953"/>
        <property type="gene ID" value="D3H35_20315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="28"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE02953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="271" mass="29833" checksum="BE2E52BACFC57B3D" modified="2018-12-05" version="1">MRKASIKPGANLQLKNYTSFGQTVRNSLTMAYRGLLKIRRTPEQLFDVTLQPIIFTLMFTYIFGGAISGDVQSYLPVIIPGILVQTVITTSIVTGVQLREDMDKGVFDRFKSLPIARIAPLAGALLADTIRYTIATVLTFSMGYIMGYRPDGGLDHVAIAAVLVIFCSWAISWIFAFFGVIARTASSVQGISMIVLFPLTFLSNAFVPVKTMPDWLQWFVNINPISHLVSAVRELSNSGTVGWDLVISLIGAVVIVSIFAPITVRAYMRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK04</accession>
    <name>A0A398CK04_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome C oxidase subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03033">
        <property type="protein sequence ID" value="RIE03033"/>
        <property type="gene ID" value="D3H35_20805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupredoxin_1" evidence="1">
        <location>
            <begin position="31"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="126" mass="13892" checksum="AB91908D74486BFD" modified="2018-12-05" version="1">MYKWIMSTFITVACALGVYLLATGLPDKPHDEAEGLKEGQELLKITASNFEFNEKEYHVKAGTSYVIKFSNKLGTHGAEIKDLGIELESAKPSVEYTFDKPGTYEMHCSIMCGQGHGGMIAKIIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CK54</accession>
    <name>A0A398CK54_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_10330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03686">
        <property type="protein sequence ID" value="RIE03686"/>
        <property type="gene ID" value="D3H35_10330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01011">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017319475" evidence="2">
        <location>
            <begin position="30"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="575" mass="61314" checksum="DA0285FB21A37DF0" modified="2018-12-05" version="1">MKKTLGVISAVLAVSVSLAACSDNNNSNSSPSASASSSASPSASASASPTAATAQNENFPSVHFDLASTRHVPYTEVTKDNVGELGIVWSTDFKKLDSTIPNGNQSFTVVVDGVLYVTTSKNHVFAFDAVKGTQIWHWAPDATLLENSKNLYIVANRGVAVAEGKVFMLTLDNRLIALDAKTGQTVKAVNISDAVENVTVANGYYETTAPVYFNGNVYIGSSGGDNGVRGFVMAYKASDLTPAWDAPFWTVPPKGQDWLKNNKYNGGGAVWNPSTFDEETGLMYFGTGNPAPDMYGVDRPGANPYTDSIVALDSKTGKLVWAQQEVSHDLWDYDAAATPMLIKAKINGAERKVVVHGGKSGEWFAWDAATGEVVYKNVQFAKKISHPDPTPEGVLIYPGVYGGQNYAPETYDPETNYVLIPGVESPNVVKGYEGKKEEVTPFGTTLGETPADIVPYGTVTAIDMNTGKVAYQYDTDHEMRGGFTSTAAGLAFYGELNGKVRALDIKSGKIVWEFQLDGDNVMSAPSIFTQNGKQYVAFTSGGTKPKMFVFALGGDKTQGASADGNVEGGVDHSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKA5</accession>
    <name>A0A398CKA5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ImmA/IrrE family metallo-endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_23275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01308">
        <property type="protein sequence ID" value="RIE01308"/>
        <property type="gene ID" value="D3H35_23275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M78" evidence="1">
        <location>
            <begin position="14"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="157" mass="18088" checksum="670518FEEB05F96D" modified="2018-12-05" version="1">MPYDRLLTKADQDGVEVYEEPMAPANKGLYADGVIWINKTIPTATEKACILAEELGHYHTTAGNILDQRDVRNRKQEKRARNWAVENLIPLHAFIAAFKSGVRNRFELADFLDVTEEFLDSSIRHYQEKHEFYAIHGHYIVGFDPLFVAEIFEPKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKH8</accession>
    <name>A0A398CKH8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_28715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000056">
        <property type="protein sequence ID" value="RIE00397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00397">
        <property type="protein sequence ID" value="RIE00397"/>
        <property type="gene ID" value="D3H35_28715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE00397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="319" mass="33577" checksum="C019DA1076402330" modified="2018-12-05" version="1">MISMPYTQLVRGGLKTGILYLIFAVSFLVVGFFVEGFGGLSHLSYLIQIAGFLGIVAAGQNMIMLTGGIDLSCGMIISFCGIVFAQLINSGYGFLGGILLTLLCGSLLGLANGLGVSFLKVPALVMTLATASVYQGISMVMTNGRTSSITAEGFQGWVNDKWFFGFNGVVFTWLVVILVVVFLLTNTKIGKKIYYSGSNMTAAVHSGINPKSVSLFVFTSAGFLYAIVGILLVGFTARSYFTMGNTYQFMSIAAVVVGGTSILGGKGSYLGTIAGALLLTLIQSLLILFKIPYGGQLAAQGAIILALVIIYSLQSPKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKK7</accession>
    <name>A0A398CKK7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TatD family deoxyribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_23860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01408">
        <property type="protein sequence ID" value="RIE01408"/>
        <property type="gene ID" value="D3H35_23860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE01408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="257" mass="29195" checksum="DBC60C21B74CA4AC" modified="2018-12-05" version="1">MIIDTHAHLDSPKFDNDREEVIARAREAGIDTIVNIGFNRETIPTTMALAEKYPFIYAVVGWHPTDAVDMKLEEDLAWIESLCNHPKVVAIGEIGLDYYWDTSPKELQQTVFREQIRLARKLGKPIVIHNRDAHEDILRLLKEENASEVGGIMHCFSGSWETARKCLDMNFYISFGGPVTFKNARVPKEVLERVPMDRLLLETDAPYLTPHPHRGKRNESAFVRLVAEEAASIKGVTLEEISIITSDNARRCLSLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKT4</accession>
    <name>A0A398CKT4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_20065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02910">
        <property type="protein sequence ID" value="RIE02910"/>
        <property type="gene ID" value="D3H35_20065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE02910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="252" mass="28192" checksum="E3A3444D1D237018" modified="2018-12-05" version="1">MSETAFYTKDLSVYYGEKQAIKKISMDFPEKKVVALIGPSGCGKSTFLRSLNRMNDVIPGVRVEGDIWIGDRNVNAPGTDVVKLRQNIGMVWQKPNPFHKSIYENIAFGPRYHGIRGKKQLDEIVETSLRKTALWDEVKDRLHNSGLALSGGQQQRLCIARSLAVQPSILLMDEPASALDPVSTAKIEELIAELKQDYCIVIVTHNMYQAARVSDKTGFFLMGDLVEYAETSKIFTNPTQRATDDYISGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CKZ3</accession>
    <name>A0A398CKZ3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_08545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03996">
        <property type="protein sequence ID" value="RIE03996"/>
        <property type="gene ID" value="D3H35_08545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="134"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE03996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="344" mass="38060" checksum="C809C24B02304042" modified="2018-12-05" version="1">MLKVGVIGTGGIFKWAHLPGWTSHKEVEIVAFCDAFRASAEAAAKDFPDAKVYDDYRELIDDPSIDIVGISTPNLYHSEIAIAALRKGKHVFCEKPDAVNPIEAQKMADVARESGKLLMTMRNNRFSEEAKFAKRIIEQGQLGDLYMGRCGWIRRRGIPGRGGWFTTKSLSGGGPLIDLGVHMIDMAMWLSGNPKPVTVSGSTYRKFADRPDASGNIPEGTFDVEDLAAGFIRFDNGASLQIEFSWASNIEEEKKFLEWRGTEGGFSLVNDKLSLFTENAGVLIDQQPKFPEAAVPQHTANIWHFVECVLGRETPIITPDHGVDMIKILSAIYESAELGREIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL10</accession>
    <name>A0A398CL10_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_24900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01588">
        <property type="protein sequence ID" value="RIE01588"/>
        <property type="gene ID" value="D3H35_24900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="121" mass="13764" checksum="A2366D7D8480BDC7" modified="2018-12-05" version="1">MNIAISNTSEKPIYQQLFEQISAQILKGELESGYCLPPIRQAAQELRISIITVKKAWEELERCGLINTVTGKGCFVAEFSPDEMLRIRNETILKQMVSDIEYYKSFGLTLDEVVSLLRGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLE8</accession>
    <name>A0A398CLE8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl-CoA_dh_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000038">
        <property type="protein sequence ID" value="RIE03245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03245">
        <property type="protein sequence ID" value="RIE03245"/>
        <property type="gene ID" value="D3H35_12785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="1">
        <location>
            <begin position="20"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="143" mass="15781" checksum="7A3C44F449E4C931" modified="2018-12-05" version="1">MSVIGNRKKTEQEYLEIAVSLAKKFAEDAAERDKAGGTPKAQRDWIRESGLLKLIIPEEYGGDGQSWTLALRIVREFAKEDAAVAHLFGYHLAVLANFNRVGTAAQRKHFLTKTAENGWFWGNTANSRGASKLTAVGKTANIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLF8</accession>
    <name>A0A398CLF8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_20985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03062">
        <property type="protein sequence ID" value="RIE03062"/>
        <property type="gene ID" value="D3H35_20985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="125"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="241" mass="26627" checksum="6F4EF3D3FFFE0DFD" modified="2018-12-05" version="1">MSEQQSKPAAYPQVGVASTCRDYREYIAMFGLSDDDLRRGAVLDVGGGGSSFTAQLNAMGVEAVVADPLYAAATEEVLGIVRKEIDTSSAKLAANAGAFDWSFYGSPEKHRQLREQSYRAFAEDYAREDARRRYVPASLPRLPFEDGSFSLALCSHFLFLYGADPMFDEAFHLAALKELLRVVRPGGEVRIYPMVTLQWEPYPYLSALLDQIKEIAIAKTSESSLPFTPVRSPVLTLAKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLM3</accession>
    <name>A0A398CLM3_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dipicolinate synthase subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03335">
        <property type="protein sequence ID" value="RIE03335"/>
        <property type="gene ID" value="D3H35_11660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014214">
        <property type="entry name" value="Dipicolinic_acid_synth_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001390">
        <property type="entry name" value="Dipicolinate_synth_subunit_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02852">
        <property type="entry name" value="spore_dpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="1">
        <location>
            <begin position="8"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="198" mass="21341" checksum="D94B3ECF5A411EED" modified="2018-12-05" version="1">MNWHGITVGYALTGSHCTLPEIMPQIKRFVDAGANVVPIASHTVMTTDTRFGSTEHWQTQLRELTGNEIISSIVDAEPLGPSKKLDVLTIAPCTGNTTSKLANAQTDSPVLMAAKAQMRNGRPLVLAISTNDGLGLNAANIAKLLVVKNIYFVPFGQDNPQAKPNSLVARMDLVIDACEAALQGTQLQPMIIERFQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLN1</accession>
    <name>A0A398CLN1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetolactate synthase small subunit</fullName>
            <shortName evidence="8">AHAS</shortName>
            <shortName evidence="8">ALS</shortName>
            <ecNumber evidence="8">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_15335</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02129">
        <property type="protein sequence ID" value="RIE02129"/>
        <property type="gene ID" value="D3H35_15335"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE02129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="180" mass="19945" checksum="EC586974BDB57FB8" modified="2018-12-05" version="1">MRANRKQTLSILVRNAPGVLQRVSGLFSRRSYNIESITVGESEQQGLSRIIAVADGDERTIEQIGHQLRKLIDVIEVNHLNSAPFVSRELMLIKLKTDPALRAEIQNLIQTFRCSIIDIAPESMIVQVIGSTDKNDAFVQLVARYGIVQMTRTGETAMSRDEICPVAIAGQPLGSSIVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLN7</accession>
    <name>A0A398CLN7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_11025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03563">
        <property type="protein sequence ID" value="RIE03563"/>
        <property type="gene ID" value="D3H35_11025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="61"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="269" mass="29269" checksum="7848415DDBC2499E" modified="2018-12-05" version="1">MKRNRWSAKLYLVAVFAILYAPIVYLVSYSFNSGGTMRGFDGFTLDWYKEVFADTRLLIIVLNTLVVALLSAVISTILGVIGALAVHRVRRSRNRNALLALNNVLIVSSDVVIGASFLILFTLAGVKLGFGSVLLSHIAFSVPIVVIMVLPKLQEMNPTLLDAARDLGAGGWDVLAKVVLPFIKPGIFAGFFMALTYSLDDFAVTFFVTGNGFSTLSVEIYSRARQGVSLSINALSTLLFLLTLLLVVGYYWINRRNGKAAAGPLEGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CLR9</accession>
    <name>A0A398CLR9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03385">
        <property type="protein sequence ID" value="RIE03385"/>
        <property type="gene ID" value="D3H35_11960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="66"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="205" mass="23700" checksum="07BA390FBC021764" modified="2018-12-05" version="1">MQLKWLEWAKQIQAISQAGLEYSKDMYDLERFELLRSLSIEILSEYSGIEHDKVRELFANEKGYATPKVDVRGVVFRDGKILMVKERLDGAWALPGGWADIGLSPKEVVKKEVKEESGLDVTPVRLLGIFDKKFHDHPPSPWHVYKIFVLCEIIGGQMESGMETLQVDFFPEDSLPELSVERNTEKQIKWLFESMRSKDMEVHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CM40</accession>
    <name>A0A398CM40_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA polymerase III PolC-type</fullName>
            <shortName evidence="11">PolIII</shortName>
            <ecNumber evidence="11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">polC</name>
        <name evidence="14" type="ORF">D3H35_11580</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DNA polymerase type-C family. PolC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="11"/>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03322">
        <property type="protein sequence ID" value="RIE03322"/>
        <property type="gene ID" value="D3H35_11580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00356">
        <property type="entry name" value="DNApol_PolC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024754">
        <property type="entry name" value="DNA_PolC-like_N_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028112">
        <property type="entry name" value="DNA_PolC-type_N_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006308">
        <property type="entry name" value="PolC_gram_pos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044923">
        <property type="entry name" value="PolC_middle_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14480">
        <property type="entry name" value="DNA_pol3_a_NI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11490">
        <property type="entry name" value="DNA_pol3_a_NII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01405">
        <property type="entry name" value="polC_Gram_pos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 11 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="13">
        <location>
            <begin position="339"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuclease" evidence="12">
        <location>
            <begin position="424"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE03322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="1448" mass="162251" checksum="3548A0A2F1702B46" modified="2018-12-05" version="1">MQHASDGRIRFELLLREAALPAEWIDSHFRDGYIQKVEISRTRKEWTFYFHKDTLIPASVYVGFTGRIKEKLSHIADIRAIVLNYSDAVETDELLQEYWNVFVEWMQKEFPSVNGWLAKARVEAAGGLLTIYMLDDTGLELARKKTIDAHAVRFYEERFGRVCRVKMMAGESRQEAYEQFQQKIQQESRDAIDQLIASAKEEEASSAASDGGEAPQVLQHGYDIKDEPVPIQQILEEEKKATIRGTVFGLEVKELRNGNTLYQFHVTDFTDSLTIKMFGKNKEDNKMLSLLKNGMWLKLRGRVEYDRFLNPPELVMMPSDVREMNAPAERKDDAELKRVEFHLHTTMSTMDAVTPVDAYIKTAAKWGHKAIAVSDHGNVQCFPDAVKGGKKHGIKVLFGVEANVVSDSVPMVLNPREEVIADATYVVFDIETTGLSVTANKIIELAAVKMKAGQEIDRFATFINPHEPIPYNIQQLTNITDDMVADAPELAPKLKEFLAFIGDSVLVAHNARFDIGFIQEACKSNGFPEVVNPVLDTLELARYLHPTMKNHRLNTLSDLYKVSLESHHRAIDDTLALAGVLNGLIKDANARGVTELGRLNSVNENSWKTTRPFHSGIYALNATGKKNLFKLISLSHTDYFRRVACIPRSKLIELREGLLVLSGCEKGELFETVLNKSVEEAEEVAKFYDVLEVQPLDFYIHLLDKGLVGSRAELEEALRRIVRIGEKLGKPVIATGNVHYLVPREKLFRDITIHGITGFSPLKDQRKPDAHFRTTNEMLEAFAFLGAEKAMEIVVTNTNELADRFEPFDMFPKKGGPTDNGLFSPIIDGADEEIRNTCYETAKKMYGEQLPDVVVQRLEKELVPIIKYGFSANYLISERLVKKSNEDGYLVGSRGSVGSSVVATFLGISEVNPLPAHYLCLNPECRHSEWFLDGSVPSGFDLPNKNCPNCGKPMKGEGQDIPFETFLGFKGDKVPDIDLNFSGEYQPQAHNYTKVLFGEKSVFRAGTIGTVAEKTGFGYAKKYQEDHGKSWRGAELNRIAAGVTGVKRSTGQHPGGIVVVPNYIDVEDITPVQYPADDTSADWKTTHFDYHAFDENLLKLDILGHDDPTMMRMLQDLTGVDPTTIPMNDPKVMSLFNSVEALGVQPQTIRSPVATFGVPEMGTRFVRQMLEETKPSSFADLLQISGLSHGTGVWLGNAQELIKNGTCTIKTVIGCRDDIMLFLIYKAGMDASLAFKITESVRKGKGLTPEWIEEMKRCGVPQWYIDSCLRIEYMFPKAHASAYVISAVRTAYFKLYYPIQYYATYFSVRAADFDVELFCQGYDAILKMLLEIEGKGFQATTKEKNMISILEMGLEMTARGFKVKPIDLYRSDATRFIVDGDALVPPFSSVAGVGENAARNIAAARDDGEYLSVEDFQQRSKASKTIVELLSGLGCFRGMPESNQLMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMB2</accession>
    <name>A0A398CMB2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LysE family translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_11990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03390">
        <property type="protein sequence ID" value="RIE03390"/>
        <property type="gene ID" value="D3H35_11990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="199" mass="20956" checksum="E25BA977B404D0AD" modified="2018-12-05" version="1">MHSLIEGFILGLSIAAPVGPIGILCIRKTLNQGRRMGFVSGMGAATADAIYGSVAAFGLSFITSALVDHSVWLQWLGGAFLCYLAITTFRSKPTATAGTDSASSFGFVRTFATTFLLTLSNPMTVFSFIAVFSGMNAGGEGGSAVSLVAGVFLGSAAWWFVLCMAVGFFRRMMSPRLMQAINYSSGVILLGFGIFILLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMG6</accession>
    <name>A0A398CMG6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_17140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02429">
        <property type="protein sequence ID" value="RIE02429"/>
        <property type="gene ID" value="D3H35_17140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="188"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE02429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="296" mass="33209" checksum="EC1EE7AABF3C1B7F" modified="2018-12-05" version="1">MKKVFILGGTTFDSIVYLQNLPKPEPQTIHYAPYHETMGSTGASKALNLTKLNVANTLHSIIGNDWYGEQIVQKLEAAGVRFLYDVDPKGTERHINLLDENGGRISIFITQSSSELELNLAVIEEEIRTCDAIILNIIGYTKQLLPLLKKYNKPVWTDLHDYNVGNPYHEDFIDMADYIFVSSDNMPDYRPVMEQWIARGKELVVCTHGKGGSTALTKDGQWIETPIIRDYPYKDANGAGDSFFSGFMYGAFQSKSVEECLKLGTIVAGLCITSSELAYEGLSEELVTKEFEKYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMI9</accession>
    <name>A0A398CMI9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_12500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03470">
        <property type="protein sequence ID" value="RIE03470"/>
        <property type="gene ID" value="D3H35_12500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017348039" evidence="1">
        <location>
            <begin position="26"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="96" mass="10208" checksum="0650F521A4F76ADF" modified="2018-12-05" version="1">MKHRRFLTIIPITLLLLSAASYLMSDGSKSFPAATISDNGKLKAVVLTDAANNPKAMKEQKFTYTITDENGQSVSGAVVDVSLTMPVCSAASFPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMP7</accession>
    <name>A0A398CMP7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_11020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03562">
        <property type="protein sequence ID" value="RIE03562"/>
        <property type="gene ID" value="D3H35_11020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="57"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="267" mass="30242" checksum="0AFC9F30126D6B21" modified="2018-12-05" version="1">MRAKSRNLFLIPYGAWIALFVIAPIALVLYYSFQDIEGGWSLGNYSHFFTPVYLRMALSSFWYALLITAFSLLFAYPTAYLLTKTKHKRLWLLLVILPSWINLLLKTYAFIGIFGTYGFVNAIFDSIGIGRQQILFTDFSFLFVSVYIFIPFMILPIFNSLEELNPSLVHAARDLGASPWTTFRRIVFPLTIDGVKSGCQAVFIPALSLFMITRLIAGNRVITLGTAIEQHFLVTQDWGMGATISVFLVIVMVAMMIVTGQRKKVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMS5</accession>
    <name>A0A398CMS5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_10660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000035">
        <property type="protein sequence ID" value="RIE03592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03592">
        <property type="protein sequence ID" value="RIE03592"/>
        <property type="gene ID" value="D3H35_10660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="96" mass="10947" checksum="E85FDF2C8ABD8DEE" modified="2018-12-05" version="1">MAVLDFQQPIRGNGYPIYYPFEGRGAHLLTPDKLSPAVRPGGLPDVQLQFYRGSNPMLPPQPYGLLDIRLEARYPFEEALVKLRELHPEPGLNRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMS9</accession>
    <name>A0A398CMS9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_29765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000063">
        <property type="protein sequence ID" value="RIE00224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00224">
        <property type="protein sequence ID" value="RIE00224"/>
        <property type="gene ID" value="D3H35_29765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="13"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="558" mass="64661" checksum="D32308EF96DFC840" modified="2018-12-05" version="1">MQKKWWKESVVYQIYPRSFMDSNGDGIGDLPGIISKLDYLKTLGIDVIWLSPVYESPNDDNGYDISDYRSILKDFGTMADWELFLKEAHLRGIKLIMDLVVNHSSDEHAWFVESRSSKDNPKRDYYIWRPGKDGKEPNNWVSVFSGSAWKYDETTDEYFLHLFSSKQPDLNWESDKLKREIYDMMTWWLDKGIDGFRMDVVNFISKDTAYPDAPGEGGGYHWGGEYFMNGPRIHEFLHEMNREVLSKYDCMTVGEMPGVTPEEAVKYTSPESQEVDMVFQFEHMDLDSGNGKWDVRPWTLAALRENANKWQTSLQGKGWNSLYMNNHDQPRMVSRFGDDGRYRVESAKMLATYLHMQQGTPYIYQGEEIGMTNVQFPSIADYQDIEILNYYKEQIERGANEADLLKAIHIKGRDNARTPIQWDDTLHGGFTTGTPWLQVNPNYKDINAAQALADPQSIFHYYRQLIQLRKQHEVIVYGDFEMLAWEHGEIMAYKRTLGGQSLLAIMNFYGGTPEWTLPEPFVKGQAKLLIGNYPTEGETIASERIVLKPYEARVYLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CMY4</accession>
    <name>A0A398CMY4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">parE</name>
        <name evidence="7" type="ORF">D3H35_04325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04716">
        <property type="protein sequence ID" value="RIE04716"/>
        <property type="gene ID" value="D3H35_04325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005740">
        <property type="entry name" value="ParE_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01058">
        <property type="entry name" value="parE_Gpos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toprim" evidence="6">
        <location>
            <begin position="440"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="657" mass="72797" checksum="FABF5FCA113E7022" modified="2018-12-05" version="1">MTDQLDLFAKNAVRGETEYGADDIQVLEGLTAVRKRPGMYIGSTTASGLHHLVWEIVDNAVDEHLAKYCSKIDVTVHSDNSITVFDNGRGIPTGMHKTGIPTPQVVYTILHAGGKFGGGGYKKSGGLHGVGASVTNALSEWLEVEIYREGKIHKMRFETWTDADGKEHVGEPVGGLQVTGNTNRTGTKVTFKPDRKVFHGHVSLNYDTLSERLQEIAFLNSGLKVTLTDKRSGKDDVFHYEGGARQFVQFLNEEKTVLHDVIHFSAERDDIEVEVALQYNDGYTETLASFVNAIPTRGGGTHETGFKTAYTRIMNEYARKTGQLKEKEKNLEGNDLREGMMAVINIKMSDVEFVGQTKDQLGSASARGVVDAIVAEKMAVFLEENPQVAGMLLKKSIQASKAREAARKAREEIRSGKKRSESASLGGKLSPAQSKDASRNELFIVEGDSAGGSAKQGRDSKHQAILPLKGKPMNPEKSKLLDILKNDEYKAIIAAIGAGIGSEFDVEECNYSKIVIMTDADTDGAHIQVLLLTFFYRYMKPLIDAGRVFIAQPPLYKITRKSGKLETVRYAWTDDQLNNYLKEIGKGAELQRYKGLGEMNPDQLWETTMNPETRTFLQVQIEDAAKAERRVSTLMGDKVDPRKRWIIENVDFTEYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CN08</accession>
    <name>A0A398CN08_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetolactate synthase small subunit</fullName>
            <shortName evidence="8">AHAS</shortName>
            <shortName evidence="8">ALS</shortName>
            <ecNumber evidence="8">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_10255</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="8"/>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03672">
        <property type="protein sequence ID" value="RIE03672"/>
        <property type="gene ID" value="D3H35_10255"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="6"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="161" mass="17369" checksum="2319CC5B94701BF0" modified="2018-12-05" version="1">MSRKHTIAILVNDQPGVLQRVSGLFGRRGFNIESITVGASEEPGLSRMVIVTTGDGNTLEQVQKQLYKLIDVIKVIDISGSPMVARELGLIKVNAEPSSRPEILGIVETFRAAVVDIGPTTLVVQAVGDTDKIDAMVELLKPYGIRELSRTGVTAMNRGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNL2</accession>
    <name>A0A398CNL2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_19610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02839">
        <property type="protein sequence ID" value="RIE02839"/>
        <property type="gene ID" value="D3H35_19610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038756">
        <property type="entry name" value="CheX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028051">
        <property type="entry name" value="CheX-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39452">
        <property type="entry name" value="PTHR39452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13690">
        <property type="entry name" value="CheX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheX" evidence="2">
        <location>
            <begin position="44"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="152" mass="16494" checksum="94B2957632CCABE3" modified="2018-12-05" version="1">MKAEYINPFLESARMVIEQMVQIRPSTGQLTIRDIKFAENHVWIQIGLTGQMTGDIVFGLSEQVALRIISAMMGGFVITEIDEMGKSAISELGNMISGNASTMLYNQGVHVDITPPRVVQPSISSSNGAMRALAVPLIMDGIGEMEIQVLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNL8</accession>
    <name>A0A398CNL8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase_M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">D3H35_22480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01171">
        <property type="protein sequence ID" value="RIE01171"/>
        <property type="gene ID" value="D3H35_22480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="145"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE01171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="419" mass="48002" checksum="81EA85154C0B9479" modified="2018-12-05" version="1">MSNQQVEVCPTCGHSMPVIPGYVTWCEQCDWNISPTESDAKSPTLMRRLQSRLGARSANLLYEELSNAAVSTHPVTLGTIGAYLFSFLLHAASIGMVCLAIHEIFWSRTIGEFMLGFIILAVSVVLFWPVKRKIHGMKLHRSDYPALHRLMDEIANQLNAPKVDRLVANSEFNAFITRTGMRRKSVVGIGIPLFSVLNLQEKISVLAHEMGHHANADLTRRFIVRQALRTLGLWYGFLFPKTDYLEIIGPFHYVIAFIRKRLADVVYYAYLLLGLSVWKQSQRAEYFADMTSARIAGTEAAVSALGKMHFAPTFFMTLKKVAHYRYSNELFEEVRKFTRSIPEKEERRLNKIRESAPASLDDTHPPTLYRIRHLNRQPVGSFGLSMDESFCEQLNQEFAQLEKATERRLLDDYRAWYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNM0</accession>
    <name>A0A398CNM0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YheC/YheD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03922">
        <property type="protein sequence ID" value="RIE03922"/>
        <property type="gene ID" value="D3H35_08125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026838">
        <property type="entry name" value="YheC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38437">
        <property type="entry name" value="PTHR38437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14398">
        <property type="entry name" value="ATPgrasp_YheCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="390" mass="44282" checksum="4516215CA3A5B4F2" modified="2018-12-05" version="1">MLPRPLPADAASSSDRFEDKPVFAILTIDDDIQLFRGNRQNFADLLKTGEKMGFTAYVVTVGNLKLKSARVLGYTYREEDDAWVKAWFPSPGVIYNRIPQREDEMLPHVKRKLVAIARTPGIRLFNRRFFNKWSLFKWLNENRLSRRYIPETKRLTAPVVLASLLKRHRLLYLKPVRGKAGVGIMSVKVQPEKSLPYRLQIQEEKGSRTFRCATLGRLWGKMRSESASSGEPYIAQQGIQLAAVGERPFDLRALVQKNAEGQWELTGIGARVAGISSITTHVPRGGYIDDPEKLLVSVFGREKAGKVLGKVRGTAVLLARQIERSSRLRLGEMSMDLGIDSDGNVWFFEANSKPMKFDEPHIRGKSLERIFQYSLYLHRLNQKRKGGGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNQ4</accession>
    <name>A0A398CNQ4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_24665</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01547">
        <property type="protein sequence ID" value="RIE01547"/>
        <property type="gene ID" value="D3H35_24665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="198"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="265"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE01547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="488" mass="55119" checksum="151BC717E9D3FBB5" modified="2018-12-05" version="1">MSIRLKLILTYIVGILLTAAIVMVTGIGLVTGVVSYFAKGIVKDQTPREAFQRGIDLIVDLRYAERYKSEELTSPAFASLLGDQLQPFGGFLVVQEGERWESYGALKKKDTFLEQLRKDVSKPGKHADGAFTVSSWEGRDLFALRYDFPAIDDPLTYYLVIDVTEVWTKGDRFPLFVLLGIAILFGIILVPLIWITTKDIVRPLRQLEQGSRRIAEGDLNFSLQSKVRNEVGSVIRSYEKMRSELQQSIGAQLALEENRKELISNISHDLKTPLTSIKGYVEGIREGIANDPEKLRKYIDVIYTKTLDMDRMIDDLFLLSKLDLEQEKFHFDAVSLEEFYQQTMSELYIEYERAGIRLTGEYEAGSDAVATMDAQKIKRAILNIVGNSVKFMDKKEPHIHVCFGRQSEAWVIAVRDNGPGMEQSELVRIFDRFYRADANRNQNVAGSGLGLAIVKQIVAFHGGTITARSELGQSMTVMFTIPMNRSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNU7</accession>
    <name>A0A398CNU7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="6">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="6">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">D3H35_08055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="6"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03910">
        <property type="protein sequence ID" value="RIE03910"/>
        <property type="gene ID" value="D3H35_08055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="30"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="187"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="215"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE03910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="227" mass="23855" checksum="ED6757CE323076F5" modified="2018-12-05" version="1">MAKGNARRSGSPHRRRDEVIRAGGTVLIATKNRGKTKEFRKAFEPIGVTVTDLNETDGIPPIEETGVTFAENAMLKAREVARLTGIPVLADDSGLCVDALGGAPGVYSARYAGEGAGDKANNAKLLSELGAGTAQTDAEPSGEPRTLSAARFVCSLALYDPATDTAVTSEGTVEGLILAEPRGEAGFGYDPLFWVPGFGRSMAELTPEEKNAISHRGNALKLLLEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNV7</accession>
    <name>A0A398CNV7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_17070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02418">
        <property type="protein sequence ID" value="RIE02418"/>
        <property type="gene ID" value="D3H35_17070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="67" mass="7766" checksum="21E4E4299E77B294" modified="2018-12-05" version="1">MRCFNVCKGVFILNLVRQAQEEKRRIFFSTITECEVLSGIKHNLALVSRDSDMNFVTNEYGIILLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CNY4</accession>
    <name>A0A398CNY4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1540 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04225">
        <property type="protein sequence ID" value="RIE04225"/>
        <property type="gene ID" value="D3H35_06295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011437">
        <property type="entry name" value="DUF1540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07561">
        <property type="entry name" value="DUF1540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1540" evidence="1">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="78" mass="8510" checksum="DC766C7F7BBBCBF3" modified="2018-12-05" version="1">MPNGVACSVSNCAFWDQGNRCGAKEIVIEIDEHSRSRWNEEFGEEGFGEHQDHASASSVTCCLTFKPGKLSASDRSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP50</accession>
    <name>A0A398CP50_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_26200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00694">
        <property type="protein sequence ID" value="RIE00694"/>
        <property type="gene ID" value="D3H35_26200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="81"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="133"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE00694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="408" mass="46261" checksum="365705C83CC040DE" modified="2018-12-05" version="1">MDSAALRSNRQPVQRLPAPASIPGAIERDCAGVRSRRRAEVGSIRHRACHRSYESQLPKQARHGNGRRHRESDVKLIFPPFQKTTGESPIEYLTKLRMDSAKSLLSQKKCTIKTVSSAVGYEDEFHFSRMFHRHVGVPPTFYRKVKKLRVAVAASLPYRDSLLSFGVEPVASVNLFRYPGMAVKEYELVFASQWEELERAKPDLIIGDFYHFSFRDRFQGIAPVSSLLADRSWVNNYRKMAEILGSSEEAEQAVNRLAMRVAAARSLLAARMGGKSIVVLQVTNHNIRIQGATDHPLSELLFGELGLQPGRTEQSNAKRLELQPEWLPQIDTDYALVFQNHIRAGSETIYDRMCGTHAWRSMRAVQNGNVLLIPNWFKMSWSPIGREEIIDELLMMTDTLPEAAKESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPF1</accession>
    <name>A0A398CPF1_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="17">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">murB</name>
        <name evidence="20" type="ORF">D3H35_00195</name>
        <name evidence="19" type="ORF">D3H35_06500</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 17">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 17">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 17">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 17">Belongs to the MurB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="17"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000003">
        <property type="protein sequence ID" value="RIE05460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04262">
        <property type="protein sequence ID" value="RIE04262"/>
        <property type="gene ID" value="D3H35_06500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05460">
        <property type="protein sequence ID" value="RIE05460"/>
        <property type="gene ID" value="D3H35_00195"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 17" id="KW-0132">Cell division</keyword>
    <keyword evidence="12 17" id="KW-0133">Cell shape</keyword>
    <keyword evidence="16 17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 17" id="KW-0274">FAD</keyword>
    <keyword evidence="9 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 17" id="KW-0521">NADP</keyword>
    <keyword evidence="14 17 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13 17" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="18">
        <location>
            <begin position="29"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RIE04262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RIE05460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="301" mass="31848" checksum="997E3733101507ED" modified="2018-12-05" version="1">MQQLTAELEHAGVGRVWTNEPLANHTTWKIGGPADVLIIPDDEEQLAAALAVLHSRGVPWTMLGRGSNTLVSDKGVRGAVIKLGDGFGGLRFEGNAAQAGASYSFIKLSVMSGKEGLTGLEFAGGIPGTVGGAVYMNAGAHGSDVSRVFKSADIVWEDGSMATLGKEEMAFSYRHSVLQERRGIVTRAVLELAPGDRKEIAAAMASYKDRRLRTQPLQMACAGSVFRNPPNDHAARLIEAAGLKGAREGGAEVSLLHANFIVNHGGATAEDVLKLIQRVQGAIADRFGIDLVPEVLLMGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPN8</accession>
    <name>A0A398CPN8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3995 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04382">
        <property type="protein sequence ID" value="RIE04382"/>
        <property type="gene ID" value="D3H35_07280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025058">
        <property type="entry name" value="DUF3995"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13160">
        <property type="entry name" value="DUF3995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="155" mass="16756" checksum="93EB16D88B0BF093" modified="2018-12-05" version="1">MGRIWRGRAYRWGDETVKDASLWGGAAILFAVSILHFYWAFGGRWGGRAAIPEKAAGEAVFVPRAPETAAVAVLVAFVGLLLLAQGGLLDAYTPNGFTYWSAVVCGSGFALRAIGEFKYVGFLKRVKGTTFAKLDSWLYSPLCALLSVVFWLAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPP5</accession>
    <name>A0A398CPP5_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHASE4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_05775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000026">
        <property type="protein sequence ID" value="RIE04513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04513">
        <property type="protein sequence ID" value="RIE04513"/>
        <property type="gene ID" value="D3H35_05775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007892">
        <property type="entry name" value="CHASE4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05228">
        <property type="entry name" value="CHASE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHASE4" evidence="1">
        <location>
            <begin position="2"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="85" mass="8981" checksum="4F873A6419435E48" modified="2018-12-05" version="1">MVRTSKGLAVIAVSRITNEEKDKPSPGLLLFGRVMDDAALQGVSSLLNAGSGDPFEGRADVGKRRSSARLFGRKCGLRPSPNSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPR7</accession>
    <name>A0A398CPR7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MBOAT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">D3H35_07510</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04422">
        <property type="protein sequence ID" value="RIE04422"/>
        <property type="gene ID" value="D3H35_07510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024194">
        <property type="entry name" value="Ac/AlaTfrase_AlgI/DltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028362">
        <property type="entry name" value="AlgI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500217">
        <property type="entry name" value="AlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016636">
        <property type="entry name" value="AlgI_DltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE04422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="376" mass="42950" checksum="FA1A14BD04A117FA" modified="2018-12-05" version="1">MRQLHDRERQYGDRPCVFSRSHCAAAGHFLLHVPADRLPGRLLQRPRASDADHRFSYVRYVFSAAGRRPIVHHGDIMPQIQDKKQPLFNRANMMLGIFLFSLGCAKKIMLADPLTGYSAAYFSGAGAADTLTAWLSSVGYTMSYYFDLSGYADMALGLALFFNIKLPHNFNSPYKARNFREYWQRWHMTLSKFLSDYVFRTVYRKGSGSFNFYSAVMVTFLVSGIWHGAGWQFVLWGAINGVLVCASHFMYRRKWKLPFWLAWTLTFAGVIATRILFVSKDAEQAMDVMRSMVSLRDFAGMDFAAFSHHLLTFGAYHLYTIVLLVIAMLISFFAPNSSEITKDFVPRYRHAVAAALLLGISLSQMTSVSKFLYFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPS4</accession>
    <name>A0A398CPS4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="6" type="ORF">D3H35_19020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02738">
        <property type="protein sequence ID" value="RIE02738"/>
        <property type="gene ID" value="D3H35_19020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="45"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="120"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="159"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="265" mass="29407" checksum="87820C21AD3A3314" modified="2018-12-05" version="1">MKYALLDRGDPLSRELAEKFHALASEHGLERSEGTPDIVLSIGGDGTLLHAFHRFRARVDDIAFIGVHTGHLGFYADWQKDELPELVEMIATSEPNKVRYPLIRVEITTRGGTSAYLALNEFTLKCVDGTLVAGIDINDEPFEMFRGDGIVISTPSGSTGYNKSLGGAVIHPSLEALQIAEIASINNRVYRTLGSSVILPKHHHCDIVPDPEEPLYIGIDHLILQMEGVLSIRCSVADDKITFARYRPFPFWHRVREAFIGSDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPX4</accession>
    <name>A0A398CPX4_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3388 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_11730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03349">
        <property type="protein sequence ID" value="RIE03349"/>
        <property type="gene ID" value="D3H35_11730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024514">
        <property type="entry name" value="DUF3388"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016784">
        <property type="entry name" value="UCP021288_ACT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11868">
        <property type="entry name" value="DUF3388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021288">
        <property type="entry name" value="UCP021288_ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="14"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="262" mass="30044" checksum="4452522801658C51" modified="2018-12-05" version="1">MEQPKQEQPKQWYMEYRISKNRPGLLGDIASLLGMLNVNILTINGVEDRARGMLLQTNDDEKIELLGKMLQKVDNITVSKLRPTRLTDILAVRHGRYIERDSDDKKTFRFTRDELGLLVDFLGEIFKREGNQTIGLRGMPRVGKTESIIAGSVCANKRWAFVSSTLLRQTVRSMLSEEEMNPNNVFIIDGIVSTIRSNEKHHQLLQDIMTMPSTKVIEHPDIFVRESGFDYDVFDCIVELRNSPDEEITYENFTTAGLGDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ45</accession>
    <name>A0A398CQ45_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_05660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04572">
        <property type="protein sequence ID" value="RIE04572"/>
        <property type="gene ID" value="D3H35_05660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="192"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="292" mass="33010" checksum="54C882A56B1899FC" modified="2018-12-05" version="1">MMDIRNLRENRRHGSPEFPAAVYRMEQAAGEPILENHWHEEAEFLAVESGEAVFQIGLSTYEVRAGEVLFIPGGELHGGYSLGGSACTYAAVVFDLDWLMGTGDGATMRYYEPLKRGQLTLVPHAAHHTGFGEELFDQVEKLIALEHSEDPAKPLWMKAGIIRLFAEYVSKGQWSRRDFASPVDARTQDRLKAVLSFIDEHYARKLTIKELAAVAGMSEGHFTRVFKSFMRKTPVEYVNQRRIRIAAELLADSNKTVGEAAIDSGFDNFSYFCKLFRSVYQCTPSEFRERRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CQ75</accession>
    <name>A0A398CQ75_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bacillithiol biosynthesis deacetylase BshB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bshB1</name>
        <name evidence="1" type="ORF">D3H35_04095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04675">
        <property type="protein sequence ID" value="RIE04675"/>
        <property type="gene ID" value="D3H35_04095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019213">
        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071793">
        <property type="term" value="P:bacillithiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023842">
        <property type="entry name" value="Bacillithiol_biosynth_BshB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04001">
        <property type="entry name" value="thiol_BshB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="237" mass="26722" checksum="ED7BE82C5BF27214" modified="2018-12-05" version="1">MTAAAHRYGLDMLIFAAHPDDAEIGMGGTIAKHTAAGNRVGLIDLTYAEMSSNGNVETRQKEAAEASKILGLAVRENLGLPDRRLAAVPEQIDLMVSAIRRHRPRIVFTPYFIDRHPDHVMCSRMTEEAVFNAKLRRYIPEEPAWTVDMLYFYFINEVHTSQVLVDISDVQERKMASVRAYRSQFMPAGSEQDWVETPLTGSYVEMVVARDRLLGQQRKLAFAEGFVPRGPVTLDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR05</accession>
    <name>A0A398CR05_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 4">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_10395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="3 4"/>
    <dbReference type="EMBL" id="QXJM01000032">
        <property type="protein sequence ID" value="RIE03699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03699">
        <property type="protein sequence ID" value="RIE03699"/>
        <property type="gene ID" value="D3H35_10395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014628">
        <property type="entry name" value="Man6P_isomerase_Firm_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036894">
        <property type="entry name" value="PMI_Firm_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE03699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="324" mass="34857" checksum="E5003922BA4EE7A9" modified="2018-12-05" version="1">MSVQPYPLHFKPEFKERVWGGRALEQFGFEVPAGHIGEGWMIADHPNGVSHVTNGELAGLGLDQIRERLGASWFGSKGGESGNGRFPLLIKLLDCNDDLSIQVHPNDDYDGLPKGELGKTEMWYVLAAKPDAKIIYGLKPGVDRESLASAIAEGRIMDSLQEVPVVAGDTFYIPAGTVHALCAGVVVAEIQQNSDTTYRLYDYDRPGLDGKPRELHIEDSLNVIAYEGSGATRMKTDGAKSGEWLTLAESPYFVTDKGIVNGAWELSTSPASFDVLIIGDGEGSIGYANGSVHARAGDCFLIPANLGSYSLEGSMTVLRSRVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR16</accession>
    <name>A0A398CR16_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ribH</name>
        <name evidence="8" type="ORF">D3H35_03650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="QXJM01000023">
        <property type="protein sequence ID" value="RIE04600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04600">
        <property type="protein sequence ID" value="RIE04600"/>
        <property type="gene ID" value="D3H35_03650"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RIE04600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="156" mass="16476" checksum="98B2972CFB2355A9" modified="2018-12-05" version="1">MAVIYEGHLVSKGLKYGIVVGRFNEFISSRLLSGALDALKRHGAEEDEVEVAWVPGAFEIPLIAQKMAESGKYDAVITLGAVIRGSTPHFDFVCNETAKGVAAIGLKTGVPTIFGVLTTDSIEQAVERAGTKAGNKGWEAAASAIEMANLSRQLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CR47</accession>
    <name>A0A398CR47_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000030">
        <property type="protein sequence ID" value="RIE03739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03739">
        <property type="protein sequence ID" value="RIE03739"/>
        <property type="gene ID" value="D3H35_09280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017209069" evidence="1">
        <location>
            <begin position="41"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE03739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="79" mass="8712" checksum="61F12EFF92B9C7DC" modified="2018-12-05" version="1">MNFFIENYKNEENESGMKKRLSAIVLSFAIMLSSFQIADAEQTVPEAVASQTNSVRSEVQNGTVNNDESGINSFFRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CRU9</accession>
    <name>A0A398CRU9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_03520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000022">
        <property type="protein sequence ID" value="RIE04910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04910">
        <property type="protein sequence ID" value="RIE04910"/>
        <property type="gene ID" value="D3H35_03520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="119" mass="13113" checksum="99789D8259E8E3AA" modified="2018-12-05" version="1">MEGTRQLSETRPLHQNPVRRHQWMFFILTNTVVVPLTLGQAFSPAAGANSRFRANVLRPDRSGLRPASLDGHRYALMEGPSGVWWGLTLSLAATAGRLRRTRAGGAAADLRQATCCRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS12</accession>
    <name>A0A398CS12_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage late control D family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_18055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02587">
        <property type="protein sequence ID" value="RIE02587"/>
        <property type="gene ID" value="D3H35_18055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE02587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="365" mass="40210" checksum="848CF4C60CCE82F4" modified="2018-12-05" version="1">MAIKFDTTTYTFDALEKKYGSFYAPAFDILIDGQSLTLQRIAVSSLTVETTIEARADSFNFRVENAYNAVSRSFNWVGSLLEVGKSITIKIGYKDKLEEVFQGIVTGISLDYPSEGQPSVTVRGMDKSMLMMRSVKSNLWRDKKVSDVVKEIGGKYGLQLQVDDTMTPVPTIEQLQASDFHFLKELAESNNHDFFVIGQKLYFKKPNASASPVITLMYGKNLKSYSTDVDISNQVSQIIVRSVDPATRIPFQAVSQSVNIMGTNGKTGANIMAALSSHLVETVYSNVQTQSEAQKLANSMLNERAMGLISGEGECIGLPELRAGRHIKLDGLGPKFNQPLRLSGVTHKIDNRGYVTNFSVEGNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS41</accession>
    <name>A0A398CS41_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_11000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000036">
        <property type="protein sequence ID" value="RIE03558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03558">
        <property type="protein sequence ID" value="RIE03558"/>
        <property type="gene ID" value="D3H35_11000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="293" mass="33266" checksum="550D12DB05309AC6" modified="2018-12-05" version="1">MHYSFSKAIVMNVTTYDTLNDKGEPLIFLLKTIFAEFLTYTAAELVVEIEKMNGRSLRSVLDDKSVKKMFELLLKGEVRFVEIRDSYKMDEDPFGDEDEIKHYPPDFSLAIMCNHAVDYAPEAQRKFIFPNGLSLALNDRLFQGSIPLNIQDTFVGIFRRTLQSIGGVMGYVTYETSSAFVGGGSAFENYHRINTSLKPGYLDFIGGYFWLNYLNDNHIARLGGPEFVRSHAPCEVVEPPGSGLLLRLTENINHYSDDSLRDLRAFLAPLFPPDTGKNEPLKFEEGYLLRLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS50</accession>
    <name>A0A398CS50_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_02520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05030">
        <property type="protein sequence ID" value="RIE05030"/>
        <property type="gene ID" value="D3H35_02520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="23"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="138"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="223" mass="23447" checksum="52D433F92DAB7F11" modified="2018-12-05" version="1">MSQESLYVRRAPSFSSKLFGLAPEAFTAFGEFNKQALAEGALTVRVKELIAVGITHITGCPYCIEAHTGKAKAEQASLSELAEVIAVAAAVNAHASYYHGVNLLAAYEGGHPEGSDLYPLGNLARVEKLAELNPHGATSFERYVDQALKPGKLTEKEKLLIAVGAAFVTGGAYSIEIFTAQAKAAGVTLQEIAEALLVAAVLNAGAVVGHRVNALHAYERVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS70</accession>
    <name>A0A398CS70_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_09045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04079">
        <property type="protein sequence ID" value="RIE04079"/>
        <property type="gene ID" value="D3H35_09045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="86" mass="9698" checksum="62C7DF63EBE99F3D" modified="2018-12-05" version="1">MFSFRSEKKQPTTDLATVESSRNDLTAEEFPEGPYGSDLLSESVGKAEWREDQRGPAPFGYENRELHANLERGYPADHDLHDQEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CS73</accession>
    <name>A0A398CS73_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01794">
        <property type="protein sequence ID" value="RIE01794"/>
        <property type="gene ID" value="D3H35_13425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="307" mass="33599" checksum="44946DBE80F0FB4B" modified="2018-12-05" version="1">MNVVLGTGPLGVAVMRELAERGESVTMVSFSGKAKLPQGVRIRKADLMDRDQAVGALKQAKVIYQCAQPSYHKWPAEFPTLQDNVVAGAIAAKAKLVVAENVYMYGFVKGSIREELPYAPNTRKGKVRAALSRQLLKLHQDGALQVAMGRGADFFGPHVHQSSAGSRFFKPIAEGKACVVMGDPDKKHSYTYIDDFGKALVVLSEHEDAFGQAWHVPNAEAVTPRELANMAYKAAGFSPVVKSMGKGTLRAAGLFIPGARESVEMMYQFENDFIVDSRKFTERFGMQATPLDIAADRTLAWFKNNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSI1</accession>
    <name>A0A398CSI1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GatB/YqeY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_06150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04199">
        <property type="protein sequence ID" value="RIE04199"/>
        <property type="gene ID" value="D3H35_06150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="PTHR28055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="147" mass="16679" checksum="7651186CC12B3909" modified="2018-12-05" version="1">MKLAEQLNEDMKQAMRDGDKFRLSTIRLIRASVKNVEIELRRELDDNDLIQIMSRELKQRRDSLLDFEKAGREDLVANVSAEIDIISQYLPQQLTEEEIKAIVEQTIQETGASSKADLGKLMGALMPKVKGRADGKLVNQLVQQALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CSL1</accession>
    <name>A0A398CSL1_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sulfate ABC transporter permease subunit CysW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysW</name>
        <name evidence="11" type="ORF">D3H35_19315</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02787">
        <property type="protein sequence ID" value="RIE02787"/>
        <property type="gene ID" value="D3H35_19315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011866">
        <property type="entry name" value="CysW_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005667">
        <property type="entry name" value="Sulph_transpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406">
        <property type="entry name" value="PTHR30406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406:SF1">
        <property type="entry name" value="PTHR30406:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00969">
        <property type="entry name" value="3a0106s02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02140">
        <property type="entry name" value="permease_CysW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="74"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RIE02787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="290" mass="31519" checksum="1BE02D48F087C667" modified="2018-12-05" version="1">MAGIVTTGRALENKSAPRHLTESRAVKWLLIGIALLFVALVILLPMASVIVESLKKGWGAYVEALKDPDALSALKLTLVTAAIAVPLNSIFGVAVAWAITKFKFRGKNLLITLIDLPFAVSPVISGLVYVLLFGAQGFFGPWLQEHDINIIFATPGIVLATMFVTFPFVARELIPLMETQGVQDEEAAVSLGARGWRMFFRVTLPNIKWALLYGLILCNARAMGEFGAVSVVSGHIRGETNTLPLHIEILYNEYQFTAAFAVASILMLLAVITLVIKSLLESRMSQNHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CT75</accession>
    <name>A0A398CT75_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Malonyl CoA-acyl carrier protein transacylase</fullName>
            <ecNumber evidence="4">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fabD</name>
        <name evidence="7" type="ORF">D3H35_07700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fabD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="4"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04459">
        <property type="protein sequence ID" value="RIE04459"/>
        <property type="gene ID" value="D3H35_07700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004410">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00128">
        <property type="entry name" value="fabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="6">
        <location>
            <begin position="7"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000446-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="311" mass="31954" checksum="45BF6AB7772846BD" modified="2018-12-05" version="1">MGKIAFVFPGQGAQAVGMGKDAFDAVQASKAVFDQADEALGFAISKLSFEGPEEELRQTANTQPALLATSIALLEAYKSQGVQPDFVAGHSLGEYSALVAAGAIAFDDAIRLVRSRGLFMEQAVPGGAGAMAAVLGAEREALDNLCRDISATGAQVELANVNSPGQIVVSGSAAGVAAVGERGKEAGAKRVISLEVSGPFHSSLMQPAADRLSEELAKVTFNDAKIPVVANVNAIAVTSGAEIRELLVKQVVSPVLWEDTIRYLIGEGVDTFVEIGSGTVLAGLIKKIDKSVRIVSVNTAAAALASESVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTB7</accession>
    <name>A0A398CTB7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine kinase</fullName>
            <ecNumber evidence="1">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_15805</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="1"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02204">
        <property type="protein sequence ID" value="RIE02204"/>
        <property type="gene ID" value="D3H35_15805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011623">
        <property type="entry name" value="7TMR_DISM_rcpt_extracell_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07695">
        <property type="entry name" value="7TMR-DISM_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="7TMR-DISM_7TM" evidence="4">
        <location>
            <begin position="33"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="5">
        <location>
            <begin position="305"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="512" mass="57545" checksum="291BCF7594BEB9E4" modified="2018-12-05" version="1">MLIDNREALNPAPWIGLIDKSDLLIHLVRKDTYSLVLAGFFLLGACVALGLYWGRRDRLHLYFFLLSLCCCYAAFVRNYLLQAYWDQPWLSYLELAVFPFGVTAFVSSIHEVFRMTLKTRVLDEFRRILFWFSCLTLASALFLNMKWYSWLLSYPLLALFLLTAVIVFWVLRSTYRDRKDPESIWMLAGFLIVTALALIHVLRIYLPAVFGRIEHFAPPLAALPFDLLSIAMFLFLLCLVRVIIYRFGVLNEKLLQFNKALEEKVAERTGELQGKTAQLKEANARLSRSMREKAETLADSKVLEERNRITGTIHDTIGHSLTATIVQLEAAKRLLDRDPLLAEDKLGASQELVRRGLEQIQQSVPMLREDSGHYDLAEAMNRLIRETESSTGATVDCTIGALPASLLLLHKRVLFQALQEGLTNGLRHGASSRFEFSLQAKNGQLLFRLASDGNTYKPAAFGFGLRAMSERVSQLGGIMTVSPGQPGCVLTVSLPYEASGQQGQGLATGGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTN5</accession>
    <name>A0A398CTN5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Crp/Fnr family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_18600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02671">
        <property type="protein sequence ID" value="RIE02671"/>
        <property type="gene ID" value="D3H35_18600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE02671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="221" mass="25293" checksum="7D61DA096783A7B0" modified="2018-12-05" version="1">MTEGQFREFKRKFGFAHSFDDDEWKHLGPVREWKKDDSPFPVEELEQRALIVLKGSLRLTHSHANGREWTVCRIREGGLFSLMASGIGRIGAEAAPFLKAEESTEALVLTSERLHRWIGKYDAFGVYVFDQIQELYAALSDRLSEMATRGLAERLCDFLEAGGWIARLSQEELAAELSTTREAVNRILKSWQRDELVEVSRKLIVVTNPLRLRQKIGAENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CTU2</accession>
    <name>A0A398CTU2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_18970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02731">
        <property type="protein sequence ID" value="RIE02731"/>
        <property type="gene ID" value="D3H35_18970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="36"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="185" mass="20259" checksum="7C9EB89316E892FE" modified="2018-12-05" version="1">MQVNYCSSCGAAMEDKNVDGTVRRACTRCEFVHWGNYSIGVGALVVKEGKLLLVRRAQEPGKGYWTNPGGYIEQLEPIQATVEREVLEESGVRAAVKAVLALRDQPRSIHNVYIAFGMEYEDGEPTPDGIEVDGAGFFSPEEMETMNVAPFTRWLVDVAVNGRSEGLTQDAEPIVPLGGYGLFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CU38</accession>
    <name>A0A398CU38_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_06255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04218">
        <property type="protein sequence ID" value="RIE04218"/>
        <property type="gene ID" value="D3H35_06255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="277" mass="30660" checksum="AF0C23C7DE9A57FF" modified="2018-12-05" version="1">MPALDDEKRKLIVNEIEAWRRGKLLPEQYCDFLQNLYLDDLDERPKGIAANAVRRIGQASRKQWMLVFGIFALICVVVLHFSAFPLALQIGLVGLTTTGFVALGGKRREQAPLKGTAVLGAGMLFLAGTGAAVLKLHGWTEGWGPIVLLSICGVLWIGCGLALRVSLFHFSGWVALIVMYALLLNRHIIDPSWIEVQAFWLPASFLFGWLSWFAHGRVRSAGTALFAVAIVLWFMPEAALALNGADPQQIEIGFLIKVIAMGAGMYRLKKQWMEWVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUE4</accession>
    <name>A0A398CUE4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Malate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 9" type="primary">mdh</name>
        <name evidence="9" type="ORF">D3H35_19945</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible oxidation of malate to oxaloacetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LDH/MDH superfamily. MDH type 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02891">
        <property type="protein sequence ID" value="RIE02891"/>
        <property type="gene ID" value="D3H35_19945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01339">
        <property type="entry name" value="LDH-like_MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00487">
        <property type="entry name" value="Malate_dehydrog_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011275">
        <property type="entry name" value="Malate_DH_type3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01763">
        <property type="entry name" value="MalateDH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="7">
        <location>
            <begin position="7"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="8">
        <location>
            <begin position="152"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="123"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RIE02891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="314" mass="33259" checksum="36578DEE177D6DCB" modified="2018-12-05" version="1">MAIKRAKITVVGAGFTGATTALMLAQKQLGDVVLLDIPQLENPTKGKALDMLESTPVQGIDSNIIGTSDYNDAANSDVVIITAGIARKPGMSRDDLVNTNAGIVKSVCENIKATSPDAYVIILSNPVDAMTYVANKALGFPKNRVIGQSGVLDTARYNTFLAQVLNVSVEDVRGVVLGGHGDDMVPLVRYTTIGGIPVEKLLPKEQIDAIVARTRVGGGEIVNLLGNGSAYFAPAASLVQMTEAILKDKKRILPIIALLEGEYGYNNLFMGVLAVLGGDGIEKIIEIELTDEEKSALEKSAQSVRNVIQIVEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUV7</accession>
    <name>A0A398CUV7_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysM peptidoglycan-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_19355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02794">
        <property type="protein sequence ID" value="RIE02794"/>
        <property type="gene ID" value="D3H35_19355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010611">
        <property type="entry name" value="3D_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06725">
        <property type="entry name" value="3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017302502" evidence="1">
        <location>
            <begin position="31"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="32"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE02794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="208" mass="21608" checksum="73051CC403438AF7" modified="2018-12-05" version="1">MILSWKKTCLKTAAFVLGGALLLPSVTAHAATAYTATDNDTFWSLSKKFGVPLTTLMSANSKIDPLNIYAGLKLTIPSTVSAKSNASVSAQSVTTAAGKSLSYSKVIDVKATAYSAAAEENGKWGGVDYFGDALELGTIAVDPKVIPLGTKLYVTGYDFNGLPVGGLVGTAKDAGSAIKGNRIDIFIPGSRSFVSGFGIQNVKVYVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CUW0</accession>
    <name>A0A398CUW0_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">D3H35_02645</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05049">
        <property type="protein sequence ID" value="RIE05049"/>
        <property type="gene ID" value="D3H35_02645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="138"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE05049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="487" mass="54269" checksum="5BF26A07FE3C703E" modified="2018-12-05" version="1">MKMNFGKIASPIASRLLVIAGFVFFSIAFVCAFVHSLTVFDSFSSASGAFLAAVIALLAVSALAMNRRVGKKAFIIIVPGVALALRLIWALLVDTPPSSDFLFMHNAALAAAKGDFSFASSDYYTSWAYQLGFTMYEALIVKLFGTPIIFLKVINVLWSTGTVALVYWTAGKAFNEFCGRAAAIAYAFYIPNIVMCSVLTNQHVSMFFFMLGCALLVHRGLTGKYSWLLIGLSFAIGHIMRPIGGVYIAALLVFVTVFRAFPWSLKRSGPLLAKTAGIVVVFYLLQATVSQSFIQTGVTAYPLANREPYWKFVVGLNTESGGVWNAADGKHMRQFKLGEERNREERRVVIERLSNVDALPSLFARKFVSFWGGPDSSAFWSMEKLNMPKQTERVNKLERAVYAAMCFFGAIGLLALVRDRQYEWHRLFLILLFGYAAIHLFIEIQGRYRLDMIPILVLLQSYGVYAAYSRITLWLSPRADRDQGVPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV07</accession>
    <name>A0A398CV07_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_19700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02854">
        <property type="protein sequence ID" value="RIE02854"/>
        <property type="gene ID" value="D3H35_19700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="57"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE02854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="258" mass="28742" checksum="07AB321963DE1007" modified="2018-12-05" version="1">MNLLRNKWVTLPLLWLFAFIVWQAGAWTYGSDIIPGPVATWKGAQELLSDGSLVQYIGISFYRVFTGWALGSLLAIPIGLIIGKVSAIRVFAEPFLNFIRFIPPIAFITLFLVWFGIGEQSKIALIMYATLFIVIINTLTGVLSVEEDKIRSARSMGASEWQILLHVVIPATTPYIFTGIRLAMGTSYMAIIGAEMIAANEGVGFLIWNSRLFFRTDWIFVGLISLGLMGFITDRAVGWIGRKTLHRYGIVSTASIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CV14</accession>
    <name>A0A398CV14_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">D3H35_03055</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIR synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000016">
        <property type="protein sequence ID" value="RIE05119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05119">
        <property type="protein sequence ID" value="RIE05119"/>
        <property type="gene ID" value="D3H35_03055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="12">
        <location>
            <begin position="58"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="13">
        <location>
            <begin position="175"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RIE05119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="346" mass="37430" checksum="2B33C8729158DF67" modified="2018-12-05" version="1">MDAGRTYRDAGVDIDKANEAKAGMTGSMVTADRRVIHKPGAFASLFVADFHDVANPVLVMKAEEPGSKQLLAFKHGRVESICYDLVNHLVNDIIVMGAKPEAVLDTILCGKLDKETVVDIVKYISNACREQGCSLIGGETSEQPGLLAEGRYMLNASIVGVVDRNKIIDGSRIRRGDAVLAIASNGLHTNGYSLVRQMMEAAPEIENLVIDGEPFLDAILRPHKCYYGPLKDLFERGAVHGMAHITGGGIAGNLARILPEGTSARIDLSLIEVLPIFSVIRSFGNVPTEDMLRTFNMGVGLTVVADPADVPVIREHLRVVGCHSYTIGEIVEGAQQVEFLGQLRWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVX2</accession>
    <name>A0A398CVX2_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">D3H35_11820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">K2E09-144</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BioY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03361">
        <property type="protein sequence ID" value="RIE03361"/>
        <property type="gene ID" value="D3H35_11820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003784">
        <property type="entry name" value="BioY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34295">
        <property type="entry name" value="PTHR34295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02632">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016661">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR016661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RIE03361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="219" mass="23519" checksum="C6BF4AFB76AAAA73" modified="2018-12-05" version="1">MTSSSTTSTLHRAELTNRRIRATVFTALFAALFIAGSFIKVPIGNLIPISMQSFAVMLAGGLLGATYGFWSIAIVVGLTACGIPLMNGAGGLAQILGPTGGFIWMFPISAFLIGFATDKLFTNRRKLGRNRQIVLLLTLFLFGSLLLYVTGVPWFMHEVPKYSNNLYSAMQAAMFSYLPGDAIKAVVATLVIAAIRPALPALRLTKKAAAKRPSKLVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CWC6</accession>
    <name>A0A398CWC6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">nusA</name>
        <name evidence="10" type="ORF">D3H35_11590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NusA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000037">
        <property type="protein sequence ID" value="RIE03324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03324">
        <property type="protein sequence ID" value="RIE03324"/>
        <property type="gene ID" value="D3H35_11590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="135"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RIE03324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="365" mass="40983" checksum="2231584A06A2D7D7" modified="2018-12-05" version="1">MSMEFIEALSEIEREKGIGKDVLLEAIEAALISSYKRNFNTAQNVRVDINRTTGQIKVYARKTIVEDALDPRMEITLEAARSINPHYQIEDIAEIEVTPRDFGRIAAQTAKQVVTQRIREAERGLIYHAYVDKEQDIVTGIVQRMDLRNLYIDLGKVEAALPLTELMPTDKFKQGDRVKSYITKVENTSKGPQIILSRTHPGLLKRLFELEVPEIFDGTVEIRSVAREAGFRSKIAVYSRNEEVDPVGSCVGPKGIRVQTVVGELKGEKIDIVRWSELVEEYVANALSPSKVLEVIVFEAEKMARVIVPDYQLSLAIGIKGQNARLAAKLTGWKIDIKSETQAEQEYGRPKTAGETMHQDSVSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXB8</accession>
    <name>A0A398CXB8_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methylamine utilization protein MauE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">D3H35_01525</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be specifically involved in the processing, transport, and/or maturation of the MADH beta-subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">One-carbon metabolism; methylamine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000014">
        <property type="protein sequence ID" value="RIE05228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05228">
        <property type="protein sequence ID" value="RIE05228"/>
        <property type="gene ID" value="D3H35_01525"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00895"/>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030416">
        <property type="term" value="P:methylamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009908">
        <property type="entry name" value="Methylamine_util_MauE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07291">
        <property type="entry name" value="MauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="MauE" evidence="11">
        <location>
            <begin position="24"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RIE05228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="193" mass="21032" checksum="10D53BA872C71B66" modified="2018-12-05" version="1">MPTTLGFLSGIAGNEWLHPAKLSSYVFEFVFALSAISKMMDLASFRRAVTDFRIVGADKAHGAANAVVVSEGLIGLGLLIVPGETVLLAAAWLMLGSFTWLAAKAWRRQLHIDCSCFGSRNRPTRWGLAFIRNVTLILTASVGCCYSNFDVPVTLPNVIFGLSILCGVLMHVSVREAIGIYRLNRGRGESWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXC5</accession>
    <name>A0A398CXC5_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_07475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04417">
        <property type="protein sequence ID" value="RIE04417"/>
        <property type="gene ID" value="D3H35_07475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE04417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="165" mass="19458" checksum="694A172C9E84AFEB" modified="2018-12-05" version="1">MSKLEGNERWKSKMLLTEHQEQYDDRKTIKKTGQPTPDELTMIRDYVLLPHMMTIVQKSIDDIGRSPNTLKRLYSATAQVILNRLSKDSLDLRRELSRRNIRIMSDEQVDLIVYHRFICRGYEDRLGIVREVMRAEINVRLARYIVEIGELIQGNPQKDDRKSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXE4</accession>
    <name>A0A398CXE4_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="3">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_07940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="3"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03891">
        <property type="protein sequence ID" value="RIE03891"/>
        <property type="gene ID" value="D3H35_07940"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042518">
        <property type="entry name" value="SirC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="PTHR35330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="218" mass="23218" checksum="E9C568C4C45BFFEF" modified="2018-12-05" version="1">MAAWYPILLDLTGKRCVVVGGGPVAERKANGLLEAGASVCVVSPRLTEGLHRLASEGRIEWRRREAEETDVQGAALLFAATSLPEANRAMAEAARKAGGLANVADDGESGDFIVPAVVRRGELILAASASGAGPALAARIAGELAVRYGEAYSDYASRLRHIRTIVKASVSDRSERRRLLAAAVTEEALEEWRTGDWPVDSDKLIARLRERAGESESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CY96</accession>
    <name>A0A398CY96_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03974">
        <property type="protein sequence ID" value="RIE03974"/>
        <property type="gene ID" value="D3H35_08420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="292" mass="31344" checksum="71FE7363A8C49883" modified="2018-12-05" version="1">MKIAAADIGGTHTKIGICDELGAIERFREFPTESHLGGPHVMNRLLERLAAYDEQCDAIAISTAGQVDTEKGRIVFANDNIPNYTGTAIREIVENRFGKPVKVENDVNAAALGEARFGAGEPYRDFLCLTFGTGVGGAIVMDRRIYRGADGVAGEFGHLFTHPLSETVGGRKPYYEAYASTTALVRMAKEADSECVDGKAIFDKIKRGNDALLRVVDAWIAEVAAGLASLVHIFNPSAIIVGGGVMEQDFLVRMVEERTRSLVLESFGGVRILKASLGNKAGLLGAASLYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ59</accession>
    <name>A0A398CZ59_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative pyruvate, phosphate dikinase regulatory protein</fullName>
            <shortName evidence="5">PPDK regulatory protein</shortName>
            <ecNumber evidence="5">2.7.11.32</ecNumber>
            <ecNumber evidence="5">2.7.4.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">D3H35_06235</name>
        <name evidence="6" type="ORF">D3H35_27410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] = AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase]</text>
            <dbReference type="Rhea" id="RHEA:43692"/>
            <dbReference type="Rhea" id="RHEA-COMP:10650"/>
            <dbReference type="Rhea" id="RHEA-COMP:10651"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:83586"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate = diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]</text>
            <dbReference type="Rhea" id="RHEA:43696"/>
            <dbReference type="Rhea" id="RHEA-COMP:10650"/>
            <dbReference type="Rhea" id="RHEA-COMP:10651"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:83586"/>
            <dbReference type="EC" id="2.7.4.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.32" evidence="5"/>
    <dbReference type="EC" id="2.7.4.27" evidence="5"/>
    <dbReference type="EMBL" id="QXJM01000050">
        <property type="protein sequence ID" value="RIE00621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00621">
        <property type="protein sequence ID" value="RIE00621"/>
        <property type="gene ID" value="D3H35_27410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04214">
        <property type="protein sequence ID" value="RIE04214"/>
        <property type="gene ID" value="D3H35_06235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016776">
        <property type="term" value="F:phosphotransferase activity, phosphate group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00921">
        <property type="entry name" value="PDRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005177">
        <property type="entry name" value="Kinase-pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026565">
        <property type="entry name" value="PPDK_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31756">
        <property type="entry name" value="PTHR31756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03618">
        <property type="entry name" value="Kinase-PPPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="151"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE00621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RIE04214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="268" mass="29566" checksum="C43494E1CFE9B2AC" modified="2018-12-05" version="1">MPNASVSVYVVSDSAGDTGEHAVRAAAAQFHPVSIHIRRASFIQSREGIDAVLTAAEAEESIVLFTLVIPYLRDYMIEQARTRKVSAIDLLGPLIDRLERSLGRESRHEPGLNHVLDADYFRKVEAVEFAVRYDDARDVTGINKADIVLIGVSRTSKTPLSMVLAHKTFKVANVPLIPELVPPKELFAVSPRKVIGLTISTESLNAIRKERLKALGLPNSASYATTERIEKELEHARQVMDKIGCIVIDVSYKAVEETASLILEHFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ69</accession>
    <name>A0A398CZ69_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_01895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05147">
        <property type="protein sequence ID" value="RIE05147"/>
        <property type="gene ID" value="D3H35_01895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="190"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="400" mass="42593" checksum="A81D1A9447C0310E" modified="2018-12-05" version="1">MRISKEEIMDAAKKLEPRLIAFRRDLHENPELSLEETETAAKVAAFLRSIGLSPKLEVGGHGVIADVVGSTPGPTIALRADMDALPIMEETGLPFASNRPGIMHACGHDAHTAIVLGAASILVERKERLAGTVRLLFQGAEEINAGAKAMIRDGALDGVDEIYGLHNLPTLAVGMAATRKGPLMGSVDRIELTLEGRGAHGAIPDQGADPIVAAAAVISGLQTIVSREVSPFSPVVVTIGSIHAGQANNVIPHRAEMTGTVRAFDPAVRRQLPDRLRRIAVRIAEAHRCEAELRYIEQVPVLVSEDGCLAHAQRTIDWLLGAERHAEAAPTLAGEDFSVYLESVPGCFFWLGSGPSDRAEDAYGLHHPKFDIQEEALAVGSAALASIALLRGQSNHSLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZ74</accession>
    <name>A0A398CZ74_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="2">DAP decarboxylase</shortName>
            <shortName evidence="2">DAPDC</shortName>
            <ecNumber evidence="2 3">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">lysA</name>
        <name evidence="6" type="ORF">D3H35_05400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="2 3"/>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04531">
        <property type="protein sequence ID" value="RIE04531"/>
        <property type="gene ID" value="D3H35_05400"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="5">
        <location>
            <begin position="44"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="4">
        <location>
            <begin position="298"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="290"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE04531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="443" mass="48034" checksum="493BE047AE026A0C" modified="2018-12-05" version="1">MYLHGTSKINAKGHLEIGGCDVTDLAKEFGTPLYIVDEALVRGRAQEFMSAFRQTGLRFQVAYASKAFCVMAMCRVAEEEGMSLDVVSDGELYTALKAGFPADRIHFHGNNKTPEEINMALDANIGCFVVDNFNELHLLNALAADKGKTVNVLLRITPGVEAHTHDYISTGQQDSKFGFDLGNGTAFRAVETTLGLANLNILGVHSHIGSQIFEVEGFRMAVEKVAAFAVEIREKLGRTFTVLNLGGGYGIRYVEGDKPLPLGVYVNAIADAVKSVCADANFPLPEVWIEPGRSIVGDAGTTLYTVGTSKDIPGVRKYIAVDGGMTDNPRPALYESKYEAVLANRANDSLEEVVSVAGKCCESGDMLIWDLNLPKVESGDLLAVFCTGAYNYAMASNYNRIRRPAVVFVKDGQADLVVARESYDNIVGNDLLPARLRKEPVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZA0</accession>
    <name>A0A398CZA0_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">D3H35_05510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000025">
        <property type="protein sequence ID" value="RIE04551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04551">
        <property type="protein sequence ID" value="RIE04551"/>
        <property type="gene ID" value="D3H35_05510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="169"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RIE04551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="270" mass="30612" checksum="F31401BC22414793" modified="2018-12-05" version="1">MEKCKLLIAEDVATVREALCKMIDWPSLGVDLTGAAESGEEALELMERNVPDILLTDIGMPKTNGLELIASVTEKYPNVKCVILSGLNEFEHARQAIRLKVHDYILKPIDPEEIQHTIGRIAEQLKRERSKQEELRAAEQKVRERLPILSERLPDLAISGNVKKSKLVEQALSTMIAGFRSRDFSLADVAANVGLSEKYLNQLFKEATGVTVYACLIRLRMDEAAELLKEPYAKVYEVCDRIGYADQDHFRESFKKQFGVTPTEYRNRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZH9</accession>
    <name>A0A398CZH9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1885 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_06965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04334">
        <property type="protein sequence ID" value="RIE04334"/>
        <property type="gene ID" value="D3H35_06965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015062">
        <property type="entry name" value="DUF1885"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036294">
        <property type="entry name" value="Rbstp2229-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08968">
        <property type="entry name" value="DUF1885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111171">
        <property type="entry name" value="SSF111171"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="139" mass="15695" checksum="1DCD5B6CEF70B737" modified="2018-12-05" version="1">MGQSAYITLVQGSAVDRIDLDGVKEQLRQYKEQMSLAGRQLGWDYADAAFPYDIKQKPEANGAWFYLKGANSLYRHIVFGTGIREDGEASSSYIQVVLPDDSTHGDKAKANELCKWIGKRLQAEVKLFNGRTLYFNPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CZY3</accession>
    <name>A0A398CZY3_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="9">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">leuS</name>
        <name evidence="15" type="ORF">D3H35_05935</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="9"/>
    <dbReference type="EMBL" id="QXJM01000027">
        <property type="protein sequence ID" value="RIE04474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04474">
        <property type="protein sequence ID" value="RIE04474"/>
        <property type="gene ID" value="D3H35_05935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="13">
        <location>
            <begin position="45"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="14">
        <location>
            <begin position="225"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="11">
        <location>
            <begin position="418"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="12">
        <location>
            <begin position="660"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="582"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="585"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RIE04474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="811" mass="91942" checksum="E908C12798691F66" modified="2018-12-05" version="1">MSEDNKQGYRPLAIEPKWQKHWDENKTFRTTEEKGKPKFYALDMFPYPSGAGLHVGHPEGYTATDIVSRYKRMKGFNVLHPMGWDAFGLPAEQYALQTGRHPREITVENINNFRRQIKSLGFSYDWEREFSTTDPDYYKWTQWIFIQLFKKGLAYVAEVPVNWCPALGTVLANEEVIDGLSERGGHPVIRKPMRQWMLKITEYAERLLEDLEELDWSESIKDMQRNWIGKSTGAEVTFAIEGHDAALTVFTTRPDTLFGATYCVLAPEHELVSAIASDEQRAAVQAYVDQAARKSDLERTDLAKDKTGVFTGAYAINPVNGAKAPIWIADYVLGGYGTGAIMAVPGHDERDWEFAKKFDLPIVEVVSGGNVEEAAFTGDGEHVNSDFLNGLSTPDAIKAMIERLENIGKGQGKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTMDTVPEDELPLLLPDVDAIEPSGTGESPLANVTDWLNVVDPKTGRKGRRETNTMPQWAGSCWYYLRFIDPSNDKEICSPEKQREWLPVDLYIGGAEHAVLHLLYARFWHKVLYDIGVVETKEPFHKLVNQGMILGMNNEKMSKSRGNVINPDDIVNEFGADTLRMYEMFMGPLEATKPWNTNGVEGVYRFLARVWRLFTDENGKLSERIQDVEGDAAFRRTWHKSVKKVTEDYEALRFNTAISQMMIFVNEAYKTDVLPKQAMEHFAQMLSPIAPHITEELWELLGHGESIAYAAWPQYDPSLTVDAEVEIAVQVNGKIVDRVNIASDLDEAGMQELALALDKVKTLIEGKTIRKLIAVKGKLVNIVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D135</accession>
    <name>A0A398D135_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_02155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000015">
        <property type="protein sequence ID" value="RIE05201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05201">
        <property type="protein sequence ID" value="RIE05201"/>
        <property type="gene ID" value="D3H35_02155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="177" mass="20734" checksum="C5BD0C9DBAD073B4" modified="2018-12-05" version="1">MNKQPGSVPFGYEPPADTEKGTLIYYDTFESSSEKEWDRVADYAIERSFRRLVLYLIHEETAKRMSRKTPVSAYYKREARLSQWLEERGDPTVSIDGWEGKRKKYTPIDSALRHLTETLPGPHFVYMTTDTANSFASFSTFESWIVNVRLLLPSEPKTAHPMLERYRHRWSPLVPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D1L9</accession>
    <name>A0A398D1L9_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_00985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05391">
        <property type="protein sequence ID" value="RIE05391"/>
        <property type="gene ID" value="D3H35_00985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE05391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="138" mass="14661" checksum="485DF75C51EFAA8F" modified="2018-12-05" version="1">MTVPTGPGEDGGASLWSQPKPAPIIGNDVWIGAGAQGDEGSRYRGRIGARSDRHRPYSGVRHCGRIPPRSFDIDSSPLNARDCGKRAGGNGRSQNSRKQRLFGDADAFSPASKTRQTSSEESGRETGRLNGIRKGAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398D2R6</accession>
    <name>A0A398D2R6_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type III-B CRISPR module-associated protein Cmr3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cmr3</name>
        <name evidence="1" type="ORF">D3H35_00890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000007">
        <property type="protein sequence ID" value="RIE05374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE05374">
        <property type="protein sequence ID" value="RIE05374"/>
        <property type="gene ID" value="D3H35_00890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010165">
        <property type="entry name" value="CRISPR-assoc_prot_TM1793"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019117">
        <property type="entry name" value="CRISPR-assoc_protein_Cmr3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09700">
        <property type="entry name" value="Cas_Cmr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01888">
        <property type="entry name" value="cas_cmr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE05374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="422" mass="47807" checksum="CD53C094BAB2D50B" modified="2018-12-05" version="1">MLMRIEPVDPIMTRDGRPFDDSPGSTASIMNEVSPGMLAGTIRTLLLKNRNGLSAIDKADLLRQLRIAGPLLEWNGHLYFPMPADLVIYEVNDILKVINLQPQSVAPDEGYFGVSVEGRQRMDLLPPLVQHYSKLYKGSPAFVREDWLYRELSGAVSADDWSRELNEWKKWRSSQSQEAAPPHSPFLQPYEREIRLHNAIDDTRGGTEEGKLFSTEALRFKPGVSLLVSIDMEGSKPDKRLKTLHSMGGKRRLARFQEIDWPQDRLFPWKCPESIASSMCKAKPGDRLRMTLATPAYFLKGWRPRWVDADFHTNEHLFECLNIPASSALRLKLQWACVDRWLPVSGWSIGRSVREGKEKAVRRMVPAGSVYFFELVDGDAGVLADNWLVSVSDTRRRKGPLDREDGFGLAIWGIESGRNCNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CDC8</accession>
    <name>A0A398CDC8_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_22565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000040">
        <property type="protein sequence ID" value="RIE01186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01186">
        <property type="protein sequence ID" value="RIE01186"/>
        <property type="gene ID" value="D3H35_22565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024726">
        <property type="entry name" value="FhuF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11575">
        <property type="entry name" value="FhuF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FhuF" evidence="1">
        <location>
            <begin position="63"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="FhuF_C" evidence="2">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE01186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="261" mass="29902" checksum="2E46CD1E6B3C495C" modified="2018-12-05" version="1">MVLAFKPEEIDVLTRDHRLAIEPSTDREFSMPAVDLLNPDKCRAYLDGVAGIFESPSSVATVSLFAKRYSFLIIASSLYAMSVYNKGMDYSIENCHIESSYQGRAWLPKMRLTEWNVSQPAEGGRKEWRDQVIHSLFAENIVKAWHSLSKLGPVSKAVLWENTAIYVYWLYENKFGEGVDDIQKSRVQEDFEYLIREAPAHLFGEKKNPFARFDSPKVVTQASEAPIRIRKTCCYYYLASDEPEDYCPTCPKIKHEVVSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CF86</accession>
    <name>A0A398CF86_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">D3H35_13790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE01856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE01856">
        <property type="protein sequence ID" value="RIE01856"/>
        <property type="gene ID" value="D3H35_13790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RIE01856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="223" mass="24458" checksum="34C22B348FF1B387" modified="2018-12-05" version="1">MSKADLVRKVIEDVNAIELEVEFRNGDKVAYSLEAEGTETREELLESILADIDWDAAEEVEIEYENGDKIEVDLEVEGEDDDDDDDDNLAEGIAGSAAREEAFVALQDAIDDVSADTDTDDQGDAVDENEEAEAESEGEAVAVDADEDIDDDEDGEVDDEDEDEDEEGEEPEDTAALEDDDGDGDEEEAETIGGAIVVDEDDDYDEDDDDDDDYTDDDDDEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CL37</accession>
    <name>A0A398CL37_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphate starvation-inducible protein PhoH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04046">
        <property type="protein sequence ID" value="RIE04046"/>
        <property type="gene ID" value="D3H35_08825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE04046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="214" mass="23902" checksum="0613CE1E5FA5728B" modified="2018-12-05" version="1">MNNSQQRILLLRVETYFTGEQMGSPPNVEGIDLGDQYELAQCDLSPYICLAIDGIADQEHLYKEKAIIESFLNLGKIVVFCGNLFRPWLPGGRSFVPRAIVDHRDYAVGNPDPAHPIFQGVRSEDMTYNKGVAGFFARGHHPLPPSATPLLTLPGGEPITYIDRQSTSGTIVVHAGNNLFGYWSEANSSGRIGPQLMQWVQEEYRRLQEGRERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CP87</accession>
    <name>A0A398CP87_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_17715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE02528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE02528">
        <property type="protein sequence ID" value="RIE02528"/>
        <property type="gene ID" value="D3H35_17715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE02528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="340" mass="36877" checksum="3CCBDAF476BBDC5D" modified="2018-12-05" version="1">MKEIARRLNLSASTVSRALNGVYGVRASTKALVIETAKAVGYVPNMGAKQLVGKGSGLIGIFAPVFRGGVHSEYLLNFYDMLQLELHKFGKDSLIFAIPYEDYPENRLTECVGSRSLEGCIILSPFGQGHPLIEEALKLGVPFVNFESVIGPHCSAIVSDDREGGRIAGRYLLSQGHRCFAYINGPPKARVSLERWDGFCEALREGGVSQDSVRVLQGDFSWESGVRAAEELRNSGAEVTAIFSSNDRMATGAIMRLAELGLSVPGDISVLGYDGDPYTAYLNPPLTTIRHASDHVSSDVVLRLMELQQGRSGTSERYPPVLLERKSVAVLTKAHSEGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CPA2</accession>
    <name>A0A398CPA2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_26595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000048">
        <property type="protein sequence ID" value="RIE00764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE00764">
        <property type="protein sequence ID" value="RIE00764"/>
        <property type="gene ID" value="D3H35_26595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="181"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE00764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="280" mass="31742" checksum="A4D9636CC8B5DA94" modified="2018-12-05" version="1">MRKPVSTTSVHPRPREGQPLAVLFAGHSQTEPLHRMGPQKLDSILVHTVIDGKGTYRCRDSDYELGAGDSFFIFPGELHTYQADGEQPWRYRWIAFRGPEADRWLLMAGITPDRPLVRGGEDVPLRAASAIEKLFRIGDWTADWEAEGWLRLAFAAWARTNRPKGPPPSESGRSVASIEADRAARWLQAQLANPVSIAQMAKELGYHRTYLTKLFSRERGMSPVRYLQQQRMGRAKLLLKEPLTVEEVAAATGYGDPLYFSKSFKRWVGCTPTEYRQSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVG6</accession>
    <name>A0A398CVG6_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sensor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">D3H35_05800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000026">
        <property type="protein sequence ID" value="RIE04518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04518">
        <property type="protein sequence ID" value="RIE04518"/>
        <property type="gene ID" value="D3H35_05800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Sensor" evidence="2">
        <location>
            <begin position="9"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RIE04518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="223" mass="24178" checksum="270897922A4D490C" modified="2018-12-05" version="1">MDDDGDVAAAGIAVFVIAIVGVCVGLPLAPFIIGLPILAATLKACERLMSGERKLAATWDRGEAHDPEHWEAQAAQSNDSERAATGWRSWIATLGRVQNYRGLLFGVAQLPATISAFTLAIVIPATFAGIALTPLAYLVSDRVFSFELFGDDWLLNRVFTNLTPENYSYIIGGIGLVLLLLTPYLIRRLGRMYAAWIRWIAGEEKAIDVSEPHGSAGLAESYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CVN2</accession>
    <name>A0A398CVN2_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">D3H35_08155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE03927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03927">
        <property type="protein sequence ID" value="RIE03927"/>
        <property type="gene ID" value="D3H35_08155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RIE03927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="75" mass="8539" checksum="24B83FCF71663654" modified="2018-12-05" version="1">MEPVTTMTESSGGLDVEDSLEAALRRKLIRLENRERKPAVYDPARRTEADVLRSLLENGIWVRPVKDAESGEREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CW32</accession>
    <name>A0A398CW32_9BACL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">D3H35_20740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">K2E09-144</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="QXJM01000039">
        <property type="protein sequence ID" value="RIE03224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE03224">
        <property type="protein sequence ID" value="RIE03224"/>
        <property type="gene ID" value="D3H35_20740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="PTHR42721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="SSF50405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="CBM6" evidence="5">
        <location>
            <begin position="806"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RIE03224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="926" mass="100605" checksum="0F50429587455F72" modified="2018-12-05" version="1">MCQYQDEIERLGVKKYKHGTEAAHGIAWLGEATYFPQPTGLACTWDTEVLKQVGEAIGTEARGFYRRDPANNGLTLWAPTVDMERDPRWGRNEEAYGEDPHLTGKLASALVKGIQGEHPFYLRAVASLKHFIGNNNEIDRGECSVSIDPRNMREYYLKAFEIPFTEGGAQSMMTSYNSVNGVPANLNPQVNDIVKKEWGMDGFVVSDAGDVLGTVNDHRYYTTYKEAVAYSILNGIDSITDDHGISKQAIRDSLAEKLLTENDLDVALRNAFRVRMRLGEFDPEDRNPYASIDESAILAPEHKEVSLLAARKSVVLLKNENEALPLDADGAGSIAIVGPLAGIVYRDWYSGTLPYTVTPLEAIQRKMNGRGQVVYASGNDRVKLGAGGKYVVIGENGKLAAAADTASDAEVFEVTDWGWRANTIVSESTGQYLTTADDRNITADSNEIFGWFTKEVFLLDGAGDVRLNVSAWNAAKIGIVENGLLAVDPELAEERSSLGSPEEKAAAAAGNEARRKVASVTFDVEKAADGLREAVEAARGSKAAIVFVGNHPLVNGKETIDRPGLSLPEAQLRLIREVAAVNPKTIVVIVGSYPFTLEGIEDEVSSIVYASHAGPELGTALADVLYGDYAPAGRLNMTWYRSEDQLPDFMDYDIIAGERTYQYFQGKTLYSFGHGLTYSAFEYDGLELNRESVAADGEVEVSLNVRNAGARASDEVVQLYIRADKSRVKRPLKQLIGFRRIHLEAGQSQSVRFNVKASELAFWDVTRDRWCVESGAYTLMIGRSSEDIAVTGSLTVVGEIVPPRNLRLPTPAINYDSYSGVIIDECKEGGSSTAAVSGGAWIGFSDAKFAKASGSFEARVSAAENGTIEIRLGSPAGEIVGVCEVPATGGTQAWHTLTCAVNVPVGRHETFLTLSAGLRLSSFRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A398CXW7</accession>
    <name>A0A398CXW7_9BACL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="10">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thrS</name>
        <name evidence="13" type="ORF">D3H35_08990</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cohnella faecalis</name>
        <dbReference type="NCBI Taxonomy" id="2315694"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Bacilli</taxon>
            <taxon>Bacillales</taxon>
            <taxon>Paenibacillaceae</taxon>
            <taxon>Cohnella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-09" db="EMBL/GenBank/DDBJ databases">
            <title>Cohnella cavernae sp. nov., isolated from a karst cave.</title>
            <authorList>
                <person name="Zhu H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">K2E09-144</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="10"/>
    <dbReference type="EMBL" id="QXJM01000029">
        <property type="protein sequence ID" value="RIE04071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RIE04071">
        <property type="protein sequence ID" value="RIE04071"/>
        <property type="gene ID" value="D3H35_08990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000266340">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGS" evidence="12">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="271"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RIE04071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000266340"/>
        </source>
    </evidence>
    <sequence length="646" mass="74220" checksum="EA93136F6D83AB88" modified="2018-12-05" version="1">MSIKVKLPDGNVREYDSGVSIEDVAFSISPGLKKNAVAGKINGKVVDLNTPIAEDVSLEILTLDSQDGLEVMRHSTAHLMAQAIKRIFGGDKVKLGIGPVIEDGFYYDIDLEQSITPDDLASIEKEMEKIVKEDLPIVRREVSREEALRIFGEIEDPLKLELIRDLPQEAVITIYDQGEFFDLCRGPHLPSTGKIKSFKLLSVAGAYWRGDSKNKMLQRIYATAFAKKAQLDEHLHFLEEAKKRDHRKLGKELNMFTFSREVGQGLPLWLPYGAKLRRTLERYIVDLEERLGYLHVYTPVLANVELYKTSGHWEHYQEDMFPPMQLDNEELVLRPMNCPHHMMVYKSEMRSYRDLPIRIAELGMMHRYEMSGALTGLHRVRAMTLNDSHIFCRLDQIKEEFKRVVQLIQRVYEDFGIKEYRFRLSYRDPQDKEKYWPDDVMWETSQRMLREVVEELDLPFFEAEGEAAFYGPKLDVQVKTALGKEETLSTAQIDVLLPDRFELEYVGDDGKKHRPVVIHRGIISTMERMTAFLLENFAGALPVWLSPVQVKVLPVSLAYESYVREVAEKLREAGVQVEADLRNEKLGYKIREAQLEKVPYMLVVGDNEASSNTVSVRRRGEGDLGAQSVEQFIERITGEISSKKVD</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>